FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Gitipour, A Al-Abed, SR Thiel, SW Scheckel, KG Tolaymat, T AF Gitipour, Alireza Al-Abed, Souhail R. Thiel, Stephen W. Scheckel, Kirk G. Tolaymat, Thabet TI Nanosilver as a disinfectant in dental unit waterlines: Assessment of the physicochemical transformations of the AgNPs SO CHEMOSPHERE LA English DT Article DE Silver nanoparticles (AgNPs); Physicochemical transformations; Dentistry; Biofilm; Antimicrobial properties ID SILVER NANOPARTICLES; MICROBIAL-CONTAMINATION; DRINKING-WATER; BIOFILM; EFFICACY; WASTE; RANGE; MODEL AB Dental unit water lines (DUWL) are susceptible to biofilm development and bacterial growth leading to water contamination, causing health and ecological effects. This study monitors the interactions between a commonly used nanosilver disinfectant (ASAP-AGX-32, an antimicrobial cleaner for dental units, 0.0032% Ag) and biofilm development in DUWL. To simulate the disinfection scenario, an in-house DUWL model was assembled and biofilm accumulation was allowed. Subsequent to biofilm development, the disinfection process was performed according to the manufacturer's instructions. The pristine nanosilver particles in the cleaner measured between 3 and 5 nm in diameter and were surrounded by a stabilizing polymer. However, the polymeric stabilizing agent diminished over the disinfection process, initiating partial AgNPs aggregation. Furthermore, surface speciation of the pristine AgNPs were identified as primarily AgO, and after the disinfection process, transformations to AgCl were observed. The physicochemical characteristics of AgNPs are known to govern their fate, transport and environmental implications. Hence, knowledge of the AgNPs characteristics after the disinfection process (usage scenario) is of significance. This study demonstrates the adsorption of AgNPs onto biofilm surfaces and, therefore, will assist in illustration of the toxicity mechanisms of AgNPs to bacteria and biofilms. This work can be an initial step in better understanding how AgNPs transform depending on the conditions they are exposed to during their lifetime. Until this date, most research has been focused on assessing the impacts of pristine (lab synthesized) nanomaterials on various systems. However, it is our belief that nano particles may undergo transformations during usage, which must be taken into consideration. Furthermore, this experiment is unique as it was conducted with a commonly used, commercially available nanosilver suspension leading to more realistic and applicable findings. Published by Elsevier Ltd. C1 [Gitipour, Alireza; Thiel, Stephen W.] Univ Cincinnati, Biomed Chem & Environm Engn, Cincinnati, OH 45221 USA. [Al-Abed, Souhail R.; Scheckel, Kirk G.; Tolaymat, Thabet] US EPA, Off Res & Dev, Natl Risk Management Res Lab, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA. RP Al-Abed, SR (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA. EM al-abed.souhail@epa.gov FU USEPA's National Risk Management Research Laboratory, Cincinnati, Ohio FX This research was performed and funded by the USEPA's National Risk Management Research Laboratory, Cincinnati, Ohio. This paper has been subjected to the Agency's internal review and quality assurance approval. The views and conclusions presented herein do not reflect the views of the Agency or its policy. This research was conducted under the USEPA's Office of Research and Development Chemical Safety for Sustainability Program. Any mention of products or trade names does not constitute a recommendation for use by the USEPA. NR 37 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD APR PY 2017 VL 173 BP 245 EP 252 DI 10.1016/j.chemosphere.2017.01.050 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA EM3KN UT WOS:000395213700027 PM 28110014 ER PT J AU Perera, L Freudenthal, BD Beard, WA Pedersen, LG Wilson, SH AF Perera, Lalith Freudenthal, Bret D. Beard, William A. Pedersen, Lee G. Wilson, Samuel H. TI Revealing the role of the product metal in DNA polymerase beta catalysis SO NUCLEIC ACIDS RESEARCH LA English DT Article ID ACTIVE-SITE; NUCLEOTIDE INSERTION; ESCHERICHIA-COLI; MECHANISM; COMPLEXES; BINDING; IONS AB DNA polymerases catalyze a metal-dependent nucleotidyl transferase reaction during extension of a DNA strand using the complementary strand as a template. The reaction has long been considered to require two magnesium ions. Recently, a third active site magnesium ion was identified in some DNA polymerase product crystallographic structures, but its role is not known. Using quantum mechanical/molecular mechanical calculations of polymerase beta, we find that a third magnesium ion positioned near the newly identified product metal site does not alter the activation barrier for the chemical reaction indicating that it does not have a role in the forward reaction. This is consistent with time-lapse crystallographic structures following insertion of S-p-dCTP alpha S. Although sulfur substitution deters product metal binding, this has only a minimal effect on the rate of the forward reaction. Surprisingly, monovalent sodium or ammonium ions, positioned in the product metal site, lowered the activation barrier. These calculations highlight the impact that an active site water network can have on the energetics of the forward reaction and how metals or enzyme side chains may interact with the network to modulate the reaction barrier. These results also are discussed in the context of earlier findings indicating that magnesium at the product metal position blocks the reverse pyrophosphorolysis reaction. C1 [Perera, Lalith; Beard, William A.; Pedersen, Lee G.; Wilson, Samuel H.] Natl Inst Environm Hlth Sci, Natl Inst Hlth, Genome Integr & Struct Biol Lab, POB 12233, Res Triangle Pk, NC 27709 USA. [Freudenthal, Bret D.] Univ Kansas, Med Ctr, Dept Biochem & Mol Biol, 3901 Rainbow Blvd,1080 HLSIC,Mailstop 3030, Kansas City, KS 66160 USA. [Pedersen, Lee G.] Univ N Carolina, Dept Chem, POB 3290, Chapel Hill, NC 27517 USA. RP Perera, L (reprint author), Natl Inst Environm Hlth Sci, Natl Inst Hlth, Genome Integr & Struct Biol Lab, POB 12233, Res Triangle Pk, NC 27709 USA. EM pereral2@niehs.nih.gov FU Intramural Research Program of the US National Institutes of Health [Z01-ES043010, Z01-ES050158, Z01-ES050159]; US National Institute of Environmental Health Sciences; US National Institutes of Health [U19CA105010] FX Research Project [Z01-ES043010 to L. P., Z01-ES050158 and Z01-ES050159 to S. H. W] in the Intramural Research Program of the US National Institutes of Health, US National Institute of Environmental Health Sciences and in association with the US National Institutes of Health Grant [U19CA105010]. Funding for open access charge: Intramural Research Program of the US National Institutes of Health, US National Institute of Environmental Health Sciences. NR 29 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0305-1048 EI 1362-4962 J9 NUCLEIC ACIDS RES JI Nucleic Acids Res. PD MAR 17 PY 2017 VL 45 IS 5 BP 2736 EP 2745 DI 10.1093/nar/gkw1363 PG 10 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EP3MO UT WOS:000397286600047 ER PT J AU Zhang, S Zhou, B Wang, L Li, P Bennett, B Snyder, R Garantziotis, S Fargo, D Cox, A Chen, L Hu, G AF Zhang, S. Zhou, B. Wang, L. Li, P. Bennett, Bd Snyder, R. Garantziotis, S. Fargo, Dc Cox, Ad Chen, L. Hu, G. TI INO80 is required for oncogenic transcription and tumor growth in non-small cell lung cancer SO ONCOGENE LA English DT Article ID CHROMATIN REMODELING COMPLEX; AMPLIFICATION; PLURIPOTENCY; REPLICATION; MECHANISMS; LANDSCAPE; BIOLOGY; ENZYME; GENES AB Epigenetic regulators are attractive targets for the development of new cancer therapies. Among them, the ATP-dependent chromatin remodeling complexes control the chromatin architecture and have important roles in gene regulation. They are often found to be mutated and de-regulated in cancers, but how they influence the cancer gene expression program during cancer initiation and progression is not fully understood. Here we show that the INO80 chromatin remodeling complex is required for oncogenic transcription and tumor growth in non-small-cell lung cancer (NSCLC). Ino80, the SWI/SNF ATPase in the complex, is highly expressed in NSCLC cells compared with normal lung epithelia cells. Further, its expression, as well as that of another subunit Ino80B, negatively correlates with disease prognosis in lung cancer patients. Functionally, INO80 silencing inhibits NSCLC cell proliferation and anchorage-independent growth in vitro and tumor formation in mouse xenografts. It occupies enhancer regions near lung cancer-associated genes, and its occupancy correlates with increased genome accessibility and enhanced expression of downstream genes. Together, our study defines a critical role of INO80 in promoting oncogenic transcription and NSCLC tumorigenesis, and reveals a potential treatment strategy for inhibiting the cancer transcription network by targeting the INO80 chromatin remodeling complex. C1 [Zhang, S.; Chen, L.] Chinese Peoples Liberat Army Gen Hosp, Dept Pulm & Crit Care Med, Beijing 100853, Peoples R China. [Zhou, B.; Cox, Ad] Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Pharmacol, Chapel Hill, NC 27599 USA. [Zhou, B.; Wang, L.] Fuwai Hosp, Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, State Key Lab Cardiovasc Dis, Beijing, Peoples R China. [Zhou, B.; Wang, L.] Fuwai Hosp, Chinese Acad Med Sci, Peking Union Med Coll, Natl Ctr Cardiovasc Dis, Beijing, Peoples R China. [Wang, L.; Li, P.; Hu, G.] Natl Inst Environm Hlth Sci, Epigenet & Stem Cell Biol Lab, 111 TW Alexander Dr,Bldg 101,Room A314, Res Triangle Pk, NC 27709 USA. [Bennett, Bd; Fargo, Dc] Natl Inst Environm Hlth Sci, Integrat Bioinformat, Res Triangle Pk, NC USA. [Snyder, R.; Garantziotis, S.] Natl Inst Environm Hlth Sci, Clin Res Branch, Res Triangle Pk, NC USA. RP Chen, L (reprint author), Chinese Peoples Liberat Army Gen Hosp, Dept Pulm & Crit Care Med, Beijing 100853, Peoples R China.; Hu, G (reprint author), Natl Inst Environm Hlth Sci, Epigenet & Stem Cell Biol Lab, 111 TW Alexander Dr,Bldg 101,Room A314, Res Triangle Pk, NC 27709 USA. EM CLA_301@163.com; hug4@niehs.nih.gov FU Intramural Research Program of the NIH; National Institute of Environmental Health Sciences [Z01ES102745]; National Institutes of Health Grants [CA042978, CA161494] FX We thank the NIEHS Animal, Epigenomics and Bioinformatics core facilities for assistance with various techniques and experiments. This study was supported in part by the Intramural Research Program of the NIH, National Institute of Environmental Health Sciences Z01ES102745 (to GH) and by National Institutes of Health Grants CA042978 and CA161494 (to ADC). NR 35 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0950-9232 EI 1476-5594 J9 ONCOGENE JI Oncogene PD MAR 9 PY 2017 VL 36 IS 10 BP 1430 EP 1439 DI 10.1038/onc.2016.311 PG 10 WC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity SC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity GA EN2TG UT WOS:000395862500011 PM 27641337 ER PT J AU Batt, AL Wathen, JB Lazorchak, JM Olsen, AR Kincaid, TM AF Batt, Angela L. Wathen, John B. Lazorchak, James M. Olsen, Anthony R. Kincaid, Thomas M. TI Statistical Survey of Persistent Organic Pollutants: Risk Estimations to Humans and Wildlife through Consumption of Fish from US Rivers SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID POLYBROMINATED DIPHENYL ETHERS; PRENATAL ORGANOCHLORINE EXPOSURE; POLYCHLORINATED-BIPHENYLS PCBS; BROMINATED FLAME RETARDANTS; STREAMS ASSESSMENT; UNITED-STATES; GREAT-LAKES; PBDES; SERUM; CONTAMINATION AB U.S. EPA conducted a national statistical survey of fish tissue contamination at 540 river sites (representing 82 954 river km) in 2008-2009, and analyzed samples for 50 persistent organic pollutants (POPs), including 21 PCB congeners, 8 PBDE congeners, and 21 organochlorine pesticides. The survey results were used to provide national estimates of contamination for these POPs. PCBs were the most abundant, being measured in 93.5% of samples. Summed concentrations of the 21 PCB congeners had a national weighted mean of 32.7 mu g/kg and a maximum concentration of 857 mu g/kg, and exceeded the human health cancer screening value of 12 mu g/kg in 48% of the national sampled population of river km, and in 70% of the urban sampled population. PBDEs (92.0%), chlordane (88.5%) and DDT (98.7%) were also detected frequently, although at lower concentrations. Results were examined by subpopulations of rivers, including urban or nonurban and three defined ecoregions. PCBs, PBDEs, and DDT occur at significantly higher concentrations in fish from urban rivers versus nonurban; however, the distribution varied more among the ecoregions. Wildlife screening values previously published for bird and mammalian species were converted from whole fish to fillet screening values, and used to estimate risk for wildlife through fish consumption. C1 [Batt, Angela L.; Lazorchak, James M.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. [Wathen, John B.] US EPA, Off Water, Off Sci & Technol, Washington, DC 20460 USA. [Olsen, Anthony R.; Kincaid, Thomas M.] US EPA, Agcy Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Corvallis, OR 97333 USA. RP Wathen, JB (reprint author), US EPA, Off Water, Off Sci & Technol, Washington, DC 20460 USA. EM wathen.john@epa.gov NR 58 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD MAR 7 PY 2017 VL 51 IS 5 BP 3021 EP 3031 DI 10.1021/acs.est.6b05162 PG 11 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA EN4FQ UT WOS:000395963800062 PM 28230353 ER PT J AU Upadhyayula, VKK Meyer, DE Gadhamshetty, V Koratkar, N AF Upadhyayula, Venkata K. K. Meyer, David E. Gadhamshetty, Venkataramana Koratkar, Nikhil TI Screening-Level Life Cycle Assessment of Graphene-Poly(ether imide) Coatings Protecting Unalloyed Steel from Severe Atmospheric Corrosion SO ACS SUSTAINABLE CHEMISTRY & ENGINEERING LA English DT Article DE Corrosion; Graphene; Civil infrastructure; Life cycle analysis; Sustainability ID GRAPHENE FAMILY NANOMATERIALS; FRESH-WATER ECOTOXICITY; IMPACT ASSESSMENT; FUNCTIONALIZED GRAPHENE; GALVANIZED STEEL; CELLS; OXIDE; NANOCOMPOSITES; TECHNOLOGIES; INCINERATION AB A major concern for exposed steel in structural applications is susceptibility to atmospheric corrosion. The International Organization for Standardization classifies atmospheric environments into six zones, C1-C5 and CX, based on factors such as humidity, airborne salinity, and acidic pollutants. The C5 and CX zones are characterized by aggressive atmospheric corrosivity that results in mass losses from steel structures. hot-dipped galvanized (HDG) zinc coatings are typically used to protect steel in C5 and CX environments. HDG coatings suffer from disadvantages related to shorter service lives and the need for frequent maintenance cycles. Graphene-reinforced poly(ether imide) (PEI) coatings have been proposed as suitable alternatives to address these issues. However, general concerns regarding the implications of nanomaterials make it necessary to understand the potential environmental impacts of these coatings. A screening-level cradle-to-grave life cycle assessment is conducted to evaluate the environmental performance of a graphene-PEI-steel structure when compared with a traditional HDG-zinc-steel structure. Impact assessment scores are calculated using the Tool for the Reduction and Assessment of Environmental and other Potential impacts v2.1 and SimaPro (v8.0.3). When considering inventory uncertainty, the graphene-PEI-steel structure yields smaller potential impacts in five of the ten categories assessed when assuming the graphene-based coating requires no maintenance during the service life of the structure. Scenario-based sensitivity studies reveal that the potential impacts are highly sensitive to the service life and maintenance needs of the coating, but insensitive to the use of thermally or chemically functionalized graphene to improve coating adhesion. Further research is needed to understand the long-term performance of the graphene-based coatings and reduce the uncertainty of the inventory. C1 [Upadhyayula, Venkata K. K.] Umea Univ, Dept Chem Environm Chem, S-90736 Umea, Sweden. [Meyer, David E.] US EPA, Natl Risk Management Res Lab, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA. [Gadhamshetty, Venkataramana] South Dakota Sch Mines & Technol, Civil & Environm Engn, 501 East St Joseph St, Rapid City, SD 57701 USA. [Gadhamshetty, Venkataramana] South Dakota Sch Mines & Technol, Surface Engn Res Ctr, 501 East St Joseph St, Rapid City, SD 57701 USA. [Koratkar, Nikhil] Rensselaer Polytech Inst, Mech & Nucl Engn & Mat Sci & Engn, Troy, NY 12180 USA. RP Gadhamshetty, V (reprint author), South Dakota Sch Mines & Technol, Dept Civil & Environm Engn, Rapid City, SD 57701 USA. EM Venkata.Gadhamshetty@sdsmt.edu FU National Science Foundation CAREER Award [1454102]; NASA [NNX16A-Q98A]; South Dakota Board of Regents under the auspices of the Surface Engineering Research Center (SERC) FX V.G. acknowledges the funding support from National Science Foundation CAREER Award (#1454102), NASA (NNX16A-Q98A), and the South Dakota Board of Regents under the auspices of the Surface Engineering Research Center (SERC). NR 90 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2168-0485 J9 ACS SUSTAIN CHEM ENG JI ACS Sustain. Chem. Eng. PD MAR PY 2017 VL 5 IS 3 BP 2656 EP 2667 DI 10.1021/acssuschemeng.6b03005 PG 12 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Chemical SC Chemistry; Science & Technology - Other Topics; Engineering GA EN2NJ UT WOS:000395846900070 ER PT J AU Gao, L Mutlu, E Collins, LB Walker, NJ Hartwell, HJ Olson, JR Sun, W Gold, A Ball, LM Swenberg, JA AF Gao, Lina Mutlu, Esra Collins, Leonard B. Walker, Nigel J. Hartwell, Hadley J. Olson, James R. Sun, Wei Gold, Avram Ball, Louise M. Swenberg, James A. TI DNA Product Formation in Female Sprague-Dawley Rats Following Polyhalogenated Aromatic Hydrocarbon (PHAH) Exposure SO CHEMICAL RESEARCH IN TOXICOLOGY LA English DT Article ID TANDEM MASS-SPECTROMETRY; TOXIC EQUIVALENCY FACTORS; DIOXIN-LIKE COMPOUNDS; LC-MS/MS METHOD; LIPID-PEROXIDATION; OXIDATIVE STRESS; POLYCHLORINATED-BIPHENYLS; SUBCHRONIC EXPOSURE; RISK-ASSESSMENT; CHEMICAL CARCINOGENESIS AB DNA oxidation damage has been regarded as one of the possible mechanisms for the hepatic carcinogenesis of dioxin-like compounds (DLCs). In this study, we evaluated the toxic equivalency factor (TEF) from the standpoint of induced DNA oxidation products and their relationship to toxicity and carcinogenicity. Nine DNA oxidation products were analyzed in the liver of female Sprague-Dawley rats exposed to 2,3,7,8tetrachlorodibenzo-pdioxin (TCDD) alone or the tertiary mixture of TCDD, 3,3',4,4',5-pentachlorobiphenyl (PCB 126), and 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) by gavage for 14, 31, and 53 weeks (5 days/week) by LC-MS/MS: 8-oxo-7,8dihydro-2'-deoxyguanosine (8-oxo-dGuo); 1,N6-etheno-2'-deoxyadenosine (1,N6-edAdo); N2,3-ethenoguanine (N2,3-8G); 7-(2oxoethly)guanine (7-OEG); 1,N2-etheno-2'-deoxyguanosine (1,N2-edGuo); malondialdehyde (M1dGuo); acrolein (AcrdGuo); crotonaldehyde (CrdGuo); and 4-hydroxynonenal (HNEdGuo) derived 2'-deoxyguanosine adducts. Exposure to TCDD (100 ng/kg/day) significantly induced 1,N6-edAdo at 31 and 53 weeks, while no increase of 8-oxo-dGuo was observed. Significant increases were observed for 8-oxo-dGuo and 1,N6-edAdo at all time points following exposure to the tertiary mixture (TEQ100 ng/kg/day). Exposure to TCDD for 53 weeks only significantly increased 1,N6-edAdo, while increases of N2,3-eG and 7-OEG were only found in the highest dose group (100 ng/kg/day). Exposure to the tertiary mixture for 53 weeks had no effect on N2,3eG in any exposure group (TEQO, 22, 46, or 100 ng/kg/day), while significant increases were observed for 1,N6-edAdo (all dose groups), 8-oxo-dGuo (46 and 100 ng/kg/day), and 7-OEG (100 ng/kg/day). While no significant increase was observed at 53 weeks for 1,N2-epsilon dGuo, M1dGuo, AcrdGuo, or CrdGuo following exposure to TCDD (100 ng/kg/day), all of them were significantly induced in animals exposed to the tertiary mixture (TEQ100 ng/kg/day). This oxidation DNA product data suggest that the simple TEF methodology cannot be applied to evaluate the diverse patterns of toxic effects induced by DLCs. C1 [Gao, Lina; Collins, Leonard B.; Hartwell, Hadley J.; Gold, Avram; Ball, Louise M.; Swenberg, James A.] Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA. [Sun, Wei] Univ N Carolina, Dept Biostat, Chapel Hill, NC 27599 USA. [Mutlu, Esra; Walker, Nigel J.] NIH, Natl Inst Environm Hlth Sci, Natl Toxicol Program, RTP, Durham, NC 27709 USA. [Olson, James R.] SUNY Buffalo, Dept Pharmacol & Toxicol, Buffalo, NY 14214 USA. RP Swenberg, JA (reprint author), Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA. EM jswenber@email.unc.edu FU NIEHS Superfund Basic Research Program [P42-ES05948]; NIEHS Center for Environmental Health and Susceptibility [P30 ES 10126]; intramural research program of the NIEHS FX This work was supported by the NIEHS Superfund Basic Research Program P42-ES05948 and the NIEHS Center for Environmental Health and Susceptibility P30 ES 10126 and in part by the intramural research program of the NIEHS. NR 66 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0893-228X EI 1520-5010 J9 CHEM RES TOXICOL JI Chem. Res. Toxicol. PD MAR PY 2017 VL 30 IS 3 BP 794 EP 803 DI 10.1021/acs.chemrestox.6b00368 PG 10 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology SC Pharmacology & Pharmacy; Chemistry; Toxicology GA EP1VB UT WOS:000397171300006 PM 28207250 ER PT J AU Shen, GF Preston, W Ebersviller, SM Williams, C Faircloth, JW Jetter, JJ Hays, MD AF Shen, Guofeng Preston, William Ebersviller, Seth M. Williams, Craig Faircloth, Jerroll W. Jetter, James J. Hays, Michael D. TI Polycyclic Aromatic Hydrocarbons in Fine Particulate Matter Emitted from Burning Kerosene, Liquid Petroleum Gas, and Wood Fuels in Household Cookstoves SO ENERGY & FUELS LA English DT Article ID EMISSION FACTORS; POLLUTANT EMISSIONS; BIOFUEL COMBUSTION; SAMPLING ARTIFACTS; SIZE DISTRIBUTION; ELEMENTAL CARBON; ORGANIC AEROSOL; ACHIEVE HEALTH; RURAL CHINA; SOLID FUELS AB This study measures polycyclic aromatic hydrocarbon (PAH) compositions in particulate matter emissions from residential cookstoves. A variety of fuel and cookstove combinations are investigated, including: (i) liquid petroleum gas (LPG), (ii) kerosene in a wick stove, (iii) wood (10 and 30% moisture content on a wet basis) in a forced-draft fan stove, and (iv) wood in a natural-draft rocket cookstove. The wood burning in the natural-draft stove had the highest PAH emissions followed by the wood combustion in the forced-draft stove and kerosene burning. LPG combustion has the highest thermal efficiency (similar to 57%) and the lowest PAH emissions per unit fuel energy, resulting in the lowest PAH emissions per useful energy delivered (in the unit of megajoule delivered, MJ(d)). Compared with the wood combustion emissions, LPG burning also emits a lower fraction of higher molecular weight PAHs. In rural regions where LPG and kerosene are unavailable or unaffordable, the forced-draft fan stove is expected to be an alternative because its benzo[a]pyrene (B [413) emission factor (5.17-8.24 mu g B[a]P/MJ(d)) and emission rate (0.522-0.583 mu g B[a]P/min) are similar to those of kerosene burning (5.36 mu g B[a]P/MJ(d) and 0.452 mu g B[a]P/min). Relatively large PAH emission variability for LPG suggests a need for additional future tests to identify the major factors influencing these combustion emissions. These future tests should also account for different LPG fuel formulations and stove burner types. C1 [Shen, Guofeng] US Environm Protect Agency, Off Res & Dev, Oak Ridge Inst Sci & Educ, 109 TW Alexander Dr,Res Triangle PK, Res Triangle Pk, NC 27709 USA. [Preston, William; Williams, Craig] CSS Dynam Inc, 1910 Sedwick Rd, Durham, NC 27713 USA. [Ebersviller, Seth M.] Univ Findlay, 1000 N Main St, Findlay, OH 45840 USA. [Faircloth, Jerroll W.] Jacobs Technol Inc, 600 William No Blvd, Tullahoma, TN 37388 USA. [Jetter, James J.; Hays, Michael D.] US Environm Protect Agency, Off Res & Dev, 109 TW Alexander Dr,Res Triangular PK, Res Triangle Pk, NC 27709 USA. RP Jetter, JJ (reprint author), US Environm Protect Agency, Off Res & Dev, 109 TW Alexander Dr,Res Triangular PK, Res Triangle Pk, NC 27709 USA. EM Jetter.jim@epa.gov FU U.S. EPA FX Funding of the study was supported by the U.S. EPA. G.S. would like to acknowledge support by an appointment to the internship/research participation program at ORD, U.S. EPA, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and EPA. The views expressed in this article are those of the authors and do not necessarily reflect the views or policies of the U.S. EPA. NR 50 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0887-0624 EI 1520-5029 J9 ENERG FUEL JI Energy Fuels PD MAR PY 2017 VL 31 IS 3 BP 3081 EP 3090 DI 10.1021/acs.energyfuels.6b02641 PG 10 WC Energy & Fuels; Engineering, Chemical SC Energy & Fuels; Engineering GA EO8WE UT WOS:000396970400104 ER PT J AU Schaider, LA Balan, SA Blum, A Andrews, DQ Strynar, MJ Dickinson, ME Lunderberg, DM Lang, JR Peaslee, GF AF Schaider, Laurel A. Balan, Simona A. Blum, Arlene Andrews, David Q. Strynar, Mark J. Dickinson, Margaret E. Lunderberg, David M. Lang, Johnsie R. Peaslee, Graham F. TI Fluorinated Compounds in US Fast Food Packaging SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS LA English DT Article ID PERFLUOROALKYL SUBSTANCES PFASS; PERFLUORINATED ALKYL SUBSTANCES; RESOLUTION MASS-SPECTROMETRY; PERFLUOROOCTANOIC ACID PFOA; HUMAN SEMEN QUALITY; GAMMA-RAY EMISSION; CARBOXYLIC-ACIDS; POLYFLUOROALKYL SUBSTANCES; FLUOROTELOMER ALCOHOLS; CONSUMER PRODUCTS AB Per-and polyfluoroalkyl substances (PFASs) are highly persistent synthetic chemicals, some of which have been associated with cancer, developmental toxicity, immunotoxicity, and other health effects. PFASs in grease-resistant food packaging can leach into food and increase dietary exposure. We collected similar to 400 samples of food contact papers, paperboard containers, and beverage containers from fast food restaurants throughout the United States and measured total fluorine using particle-induced gamma-ray emission (PIGE) spectroscopy. PIGE can rapidly and inexpensively measure total fluorine in solid-phase samples. We found that 46% of food contact papers and 20% of paperboard samples contained detectable fluorine (> 16 nmol/ cm(2)). Liquid chromatography/high-resolution mass spectrometry analysis of a subset of 20 samples found perfluorocarboxylates, perfluorosulfonates, and other known PFASs and/or unidentified polyfluorinated compounds (based on nontargeted analysis). The total peak area for PFASs was higher in 70% of samples (10 of 14) with a total fluorine level of > 200 nmol/cm(2) compared to six samples with a total fluorine level of < 16 nmol/cm(2). Samples with high total fluorine levels but low levels of measured PFASs may contain volatile PFASs, PFAS polymers, newer replacement PFASs or other fluorinated compounds. The prevalence of fluorinated chemicals in fast food packaging demonstrates their potentially significant contribution to dietary PFAS exposure and environmental contamination during production and disposal. C1 [Schaider, Laurel A.] Silent Spring Inst, Newton, MA 02460 USA. [Balan, Simona A.] Calif Dept Tox Subst Control, Sacramento, CA 95814 USA. [Blum, Arlene] Green Sci Policy Inst, Berkeley, CA 94709 USA. [Blum, Arlene] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA. [Andrews, David Q.] Environm Working Grp, Washington, DC 20009 USA. [Strynar, Mark J.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Dickinson, Margaret E.; Lunderberg, David M.] Hope Coll, Dept Chem, Holland, MI 49423 USA. [Lang, Johnsie R.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37831 USA. [Peaslee, Graham F.] Univ Notre Dame, Dept Phys, Notre Dame, IN 46556 USA. RP Schaider, LA (reprint author), Silent Spring Inst, Newton, MA 02460 USA. EM schaider@silentspring.org FU National Science Foundation [RUT-1306074] FX Funding for this project was provided by the National Science Foundation (Grant RUT-1306074) and charitable contributions to Silent Spring Institute. We thank Alex Stone, Cody Berkobien, Rochelle Cameron, Veronica Chin, Caroline Clarke, Morgan Dashko, John Harron, Nick Hubley, Eileen Kramer, Zoe Laventhol, Brieana Linton, Don Lucas, and Evelyn Ritter for assistance in sample collection and analysis, Alex Stone and Ruthann Rudel for constructive feedback on earlier versions, and Xenia Trier for helpful discussions about the development of the Danish guideline. NR 70 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2328-8930 J9 ENVIRON SCI TECH LET JI Environ. Sci. Technol. Lett. PD MAR PY 2017 VL 4 IS 3 BP 105 EP 111 DI 10.1021/acs.estlett.6b00435 PG 7 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA EO4DV UT WOS:000396645800005 ER PT J AU Griffith, MB AF Griffith, Michael B. TI TOXICOLOGICAL PERSPECTIVE ON THE OSMOREGULATION AND IONOREGULATION PHYSIOLOGY OF MAJOR IONS BY FRESHWATER ANIMALS: TELEOST FISH, CRUSTACEA, AQUATIC INSECTS, AND MOLLUSCA SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Review DE Ionoregulation; Teleost fish; Aquatic invertebrates; Major ions; Toxicity mechanisms; Freshwater toxicity ID TROUT ONCORHYNCHUS-MYKISS; ACID-BASE REGULATION; MOSQUITO AEDES-AEGYPTI; MITOCHONDRION-RICH CELLS; ZEBRAFISH DANIO-RERIO; TILAPIA OREOCHROMIS-MOSSAMBICUS; CRAYFISH PROCAMBARUS-CLARKII; BIVALVE DREISSENA-POLYMORPHA; TRANSMEMBRANE CONDUCTANCE REGULATOR; ADENOSINE-TRIPHOSPHATASE ACTIVITIES AB Anthropogenic sources increase freshwater salinity and produce differences in constituent ions compared with natural waters. Moreover, ions differ in physiological roles and concentrations in intracellular and extracellular fluids. Four freshwater taxa groups are compared, to investigate similarities and differences in ion transport processes and what ion transport mechanisms suggest about the toxicity of these or other ions in freshwater. Although differences exist, many ion transporters are functionally similar and may belong to evolutionarily conserved protein families. For example, the Na+/H+-exchanger in teleost fish differs from the H+/2Na(+)(or Ca2+)-exchanger in crustaceans. In osmoregulation, Na+ and Cl- predominate. Stenohaline freshwater animals hyperregulate until they are no longer able to maintain hypertonic extracellular Na+ and Cl- concentrations with increasing salinity and become isotonic. Toxic effects of K+ are related to ionoregulation and volume regulation. The ionic balance between intracellular and extracellular fluids is maintained by Na-vertical bar/K-vertical bar-adenosine triphosphatase (ATPase), but details are lacking on apical K-vertical bar transporters. Elevated H-vertical bar affects the maintenance of internal Na+ by Na+/H+ exchange; elevated HCO3- inhibits Cl- uptake. The uptake of Mg2+ occurs by the gills or intestine, but details are lacking on Mg2+ transporters. In unionid gills, SO42- is actively transported, but most epithelia are generally impermeant to SO42-. Transporters of Ca2+ maintain homeostasis of dissolved Ca2+. More integration of physiology with toxicology is needed to fully understand freshwater ion effects. Environ Toxicol Chem 2017; 36: 576-600. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America. C1 [Griffith, Michael B.] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Cincinnati, OH 45268 USA. RP Griffith, MB (reprint author), US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Cincinnati, OH 45268 USA. EM griffith.michael@epa.gov NR 349 TC 1 Z9 1 U1 0 U2 0 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD MAR PY 2017 VL 36 IS 3 BP 576 EP 600 DI 10.1002/etc.3676 PG 25 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA EL5YX UT WOS:000394698700007 PM 27808448 ER PT J AU Wang, N Ivey, CD Ingersoll, CG Brumbaugh, WG Alvarez, D Hammer, EJ Bauer, CR Augspurger, T Raimondo, S Barnhart, MC AF Wang, Ning Ivey, Christopher D. Ingersoll, Christopher G. Brumbaugh, William G. Alvarez, David Hammer, Edward J. Bauer, Candice R. Augspurger, Tom Raimondo, Sandy Barnhart, M. Christopher TI ACUTE SENSITIVITY OF A BROAD RANGE OF FRESHWATER MUSSELS TO CHEMICALS WITH DIFFERENT MODES OF TOXIC ACTION SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Juvenile mussels; Acute toxicity; Water quality criteria; Water quality guidelines; Species sensitivity distribution ID EARLY-LIFE STAGES; LAMPSILIS-SILIQUOIDEA; CERIODAPHNIA-DUBIA; ONLY EXPOSURES; UNIONIDAE; GLOCHIDIA; COPPER; AMMONIA; JUVENILES; ZINC AB Freshwater mussels, one of the most imperiled groups of animals in the world, are generally underrepresented in toxicity databases used for the development of ambient water quality criteria and other environmental guidance values. Acute 96-h toxicity tests were conducted to evaluate the sensitivity of 5 species of juvenile mussels from 2 families and 4 tribes to 10 chemicals (ammonia, metals, major ions, and organic compounds) and to screen 10 additional chemicals (mainly organic compounds) with a commonly tested mussel species, fatmucket (Lampsilis siliquoidea). In the multi-species study, median effect concentrations (EC50s) among the 5 species differed by a factor of <= 2 for chloride, potassium, sulfate, and zinc; a factor of <= 5 for ammonia, chromium, copper, and nickel; and factors of 6 and 12 for metolachlor and alachlor, respectively, indicating that mussels representing different families or tribes had similar sensitivity to most of the tested chemicals, regardless of modes of action. There was a strong linear relationship between EC50s for fatmucket and the other 4 mussel species across the 10 chemicals (r(2) = 0.97, slope close to 1.0), indicating that fatmucket was similar to other mussel species; thus, this commonly tested species can be a good surrogate for protecting other mussels in acute exposures. The sensitivity of juvenile fatmucket among different populations or cultured fromlarvae ofwild adults and captive-cultured adults was also similar in acute exposures to copper or chloride, indicating captive-cultured adult mussels can reliably be used to reproduce juveniles for toxicity testing. In compiled databases for all freshwater species, 1 or more mussel species were among the 4 most sensitive species for alachlor, ammonia, chloride, potassium, sulfate, copper, nickel, and zinc; therefore, the development of water quality criteria and other environmental guidance values for these chemicals should reflect the sensitivity of mussels. In contrast, the EC50s of fatmucket tested in the single-species study were in the high percentiles (> 75th) of species sensitivity distributions for 6 of 7 organic chemicals, indicating mussels might be relatively insensitive to organic chemicals in acute exposures. Published 2016 Wiley Periodicals, Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America. C1 [Wang, Ning; Ivey, Christopher D.; Ingersoll, Christopher G.; Brumbaugh, William G.; Alvarez, David] US Geol Survey, Columbia Environm Res Ctr, Columbia, MO 65201 USA. [Hammer, Edward J.; Bauer, Candice R.] US EPA, Water Qual Branch, Chicago, IL USA. [Augspurger, Tom] US Fish & Wildlife Serv, Raleigh, NC USA. [Raimondo, Sandy] US EPA, Gulf Ecol Div, Gulf Breeze, FL USA. [Barnhart, M. Christopher] Missouri State Univ, Dept Biol, Springfield, MO USA. RP Wang, N (reprint author), US Geol Survey, Columbia Environm Res Ctr, Columbia, MO 65201 USA. EM nwang@usgs.gov FU Great Lakes Restoration Initiative FX We thank the staff of the Toxicology Branch and Environmental Chemistry Branch of US Geological Survey (Columbia, MO, USA) for technical assistance, E.A. Glidewell of Missouri State University (Springfield, MO, USA) and N. Eckert of Genoa National Fish Hatchery (Genoa, WI, USA) for providing juvenile mussels for testing, T. Divis of the Kansas City Zoo for mussel culture, C. Lilavois for assistance with the USEPA Web-Interspecies Correlation Estimation database, K.L. Smalling and M.L. Hladik of the US Geological Survey (Sacramento, CA, USA) for analyses of some organic chemicals, and 3 anonymous journal reviewers for their comments. Funding for the present study was provided in part by the Great Lakes Restoration Initiative. NR 47 TC 0 Z9 0 U1 1 U2 1 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD MAR PY 2017 VL 36 IS 3 BP 786 EP 796 DI 10.1002/etc.3642 PG 11 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA EL5YX UT WOS:000394698700027 PM 27699830 ER PT J AU Ivey, CD Besser, JM Ingersoll, CG Wang, N Rogers, DC Raimondo, S Bauer, CR Hammerk, EJ AF Ivey, Chris D. Besser, John M. Ingersoll, Chris G. Wang, Ning Rogers, D. Christopher Raimondo, Sandy Bauer, Candice R. Hammerk, Edward J. TI ACUTE SENSITIVITY OF THE VERNAL POOL FAIRY SHRIMP, BRANCHINECTA LYNCHI (ANOSTRACA; BRANCHINECTIDAE), AND SURROGATE SPECIES TO 10 CHEMICALS SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Acute toxicity; Endangered species; Fairy shrimp; Interspecies correlation estimation models ID THAMNOCEPHALUS-PLATYURUS; TOXICITY TESTS; FRESH-WATER; MICROBIOTESTS; BRANCHIOPODA; CRUSTACEA; MODELS AB Vernal pool fairy shrimp, Branchinecta lynchi, (Branchiopoda; Anostraca) and other fairy shrimp species have been listed as threatened or endangered under the US Endangered Species Act. Because few data exist about the sensitivity of Branchinecta spp. to toxic effects of contaminants, it is difficult to determine whether they are adequately protected by water quality criteria. A series of acute (24-h) lethality/immobilization tests was conducted with 3 species of fairy shrimp (B. lynchi, Branchinecta lindahli, and Thamnocephalus platyurus) and 10 chemicals with varying modes of toxic action: ammonia, potassium, chloride, sulfate, chromium( VI), copper, nickel, zinc, alachlor, and metolachlor. The same chemicals were tested in 48-h tests with other branchiopods ( the cladocerans Daphnia magna and Ceriodaphnia dubia) and an amphipod (Hyalella azteca), and in 96-h tests with snails (Physa gyrina and Lymnaea stagnalis). Median effect concentrations (EC50s) for B. lynchi were strongly correlated (r(2) (_) 0.975) with EC50s for the commercially available fairy shrimp species T. platyurus for most chemicals tested. Comparison of EC50s for fairy shrimp and EC50s for invertebrate taxa tested concurrently and with other published toxicity data indicated that fairy shrimp were relatively sensitive to potassium and several trace metals compared with other invertebrate taxa, although cladocerans, amphipods, and mussels had similar broad toxicant sensitivity. Interspecies correlation estimation models for predicting toxicity to fairy shrimp from surrogate species indicated that models with cladocerans and freshwater mussels as surrogates produced the best predictions of the sensitivity of fairy shrimp to contaminants. The results of these studies indicate that fairy shrimp are relatively sensitive to a range of toxicants, but Endangered Species Act-listed fairy shrimp of the genus Branchinecta were not consistently more sensitive than other fairy shrimp taxa. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America. C1 [Ivey, Chris D.; Besser, John M.; Ingersoll, Chris G.; Wang, Ning] US Geol Survey, Columbia, MO 65211 USA. [Rogers, D. Christopher] Kansas Biol Survey, Lawrence, KS USA. [Raimondo, Sandy] US EPA, Gulf Ecol Div, Gulf Breeze, FL USA. [Bauer, Candice R.; Hammerk, Edward J.] US EPA, Chicago, IL USA. RP Ivey, CD (reprint author), US Geol Survey, Columbia, MO 65211 USA. EM civey@usgs.gov NR 28 TC 0 Z9 0 U1 0 U2 0 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD MAR PY 2017 VL 36 IS 3 BP 797 EP 806 DI 10.1002/etc.3723 PG 10 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA EL5YX UT WOS:000394698700010 PM 28019706 ER PT J AU Rushing, BR Hu, Q Franklin, JN McMahen, RL Dagnino, S Higgins, CP Strynar, MJ DeWitt, JC AF Rushing, Blake R. Hu, Qing Franklin, Jason N. McMahen, Rebecca L. Dagnino, Sonia Higgins, Christopher P. Strynar, Mark J. DeWitt, Jamie C. TI Evaluation of the Immunomodulatory Effects of 2,3,3,3-Tetrafluoro-2-(Heptafluoropropoxy)-Propanoate in C57BL/6 Mice SO TOXICOLOGICAL SCIENCES LA English DT Article DE per- and polyfluoroalkyl substances (PFASs); perfluorooctanoic acid (PFOA); immunotoxicity; TDAR ID ACTIVATED RECEPTOR-ALPHA; PERFLUOROOCTANOIC ACID; PEROXISOME PROLIFERATOR; HUMORAL IMMUNITY; SUPPRESSION; EXPOSURE; IMMUNOTOXICITY; INVOLVEMENT; SULFONATE AB 2,3,3,3-Tetrafluoro-2-(heptafluoropropoxy)-propanoate was designed to replace perfluorooctanoic acid (PFOA), which has been mostly phased out of U. S. production due to environmental persistence, detectable human, and wildlife serum concentrations, and reports of systemic toxicity. In rodent models, PFOA exposure suppresses T cell-dependent antibody responses (TDAR) and vaccine responses in exposed humans. To determine replacement compound effects on TDAR and related parameters, male and female C57BL/6 mice were gavaged with 0, 1, 10, or 100 mg/kg/day for 28 days. Mice immunized with antigen on day 24 were evaluated for TDAR and splenic lymphocyte subpopulations 5 days later. Serum and urine were collected for test compound concentrations and liver peroxisome proliferation was measured. Relative liver weight at 10 and 100 mg/kg and peroxisome proliferation at 100 mg/kg were increased in both sexes. TDAR was suppressed in females at 100 mg/kg. T lymphocyte numbers were increased in males at 100 mg/kg; B lymphocyte numbers were unchanged in both sexes. Females had less serum accumulation and higher clearance than males, and males had higher urine concentrations than females at all times and doses. While this PFOA-replacement compound appears less potent at suppressing TDAR relative to PFOA, it produces detectable changes in parameters affected by PFOA; further studies are necessary to determine its full immunomodulatory profile and potential synergism with other per- and polyfluoroalkyl substances of environmental concern. C1 [Rushing, Blake R.; Hu, Qing; Franklin, Jason N.; DeWitt, Jamie C.] East Carolina Univ, Brody Sch Med, Dept Pharmacol & Toxicol, Greenville, NC 27834 USA. [McMahen, Rebecca L.; Dagnino, Sonia] US EPA, Res Triangle Pk, NC 27711 USA. [Higgins, Christopher P.] Colorado Sch Mines, Dept Civil & Environm Engn, Golden, CO 80401 USA. [Strynar, Mark J.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. RP DeWitt, JC (reprint author), US EPA, Toxicol Assessment Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. EM dewittj@ecu.edu FU Summer Biomedical Research Program (Blake Rushing) at East Carolina University FX This study was supported, in part, by the Summer Biomedical Research Program (Blake Rushing) at East Carolina University. NR 26 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD MAR PY 2017 VL 156 IS 1 BP 179 EP 189 DI 10.1093/toxsci/kfw251 PG 11 WC Toxicology SC Toxicology GA EO9ZR UT WOS:000397047100016 ER PT J AU Bushnell, PJ Ward, WO Morozova, TV Oshiro, WM Lin, MT Judson, RS Hester, SD Mckee, JM Higuchi, M AF Bushnell, Philip J. Ward, William O. Morozova, Tatiana V. Oshiro, Wendy M. Lin, Mimi T. Judson, Richard S. Hester, Susan D. Mckee, John M. Higuchi, Mark TI Genetic Targets of Acute Toluene Inhalation in Drosophila melanogaster SO TOXICOLOGICAL SCIENCES LA English DT Article DE fruit fly; volatile organic compound; motor activity; narcosis; genome-wide association; DGRP ID NATURAL VARIATION; XENOPUS-OOCYTES; LOCOMOTOR-ACTIVITY; REFERENCE PANEL; RECEPTORS; EXPOSURE; CHANNELS; MICE; EXPRESSION; PROTECTION AB Interpretation and use of data from high-throughput assays for chemical toxicity require links between effects at molecular targets and adverse outcomes in whole animals. The well-characterized genome of Drosophila melanogaster provides a potential model system by which phenotypic responses to chemicals can be mapped to genes associated with those responses, which may in turn suggest adverse outcome pathways associated with those genes. To determine the utility of this approach, we used the Drosophila Genetics Reference Panel (DGRP), a collection of similar to 200 homozygous lines of fruit flies whose genomes have been sequenced. We quantified toluene-induced suppression of motor activity in 123 lines of these flies during exposure to toluene, a volatile organic compound known to induce narcosis in mammals via its effects on neuronal ion channels. We then applied genome-wide association analyses on this effect of toluene using the DGRP web portal (http://dgrp2. gnets. ncsu. edu), which identified polymorphisms in candidate genes associated with the variation in response to toluene exposure. We tested similar to 2 million variants and found 82 polymorphisms located in or near 66 candidate genes that were associated with phenotypic variation for sensitivity to toluene at P< 5 x 10(-5), and human orthologs for 52 of these candidate Drosophila genes. None of these orthologs are known to be involved in canonical pathways for mammalian neuronal ion channels, including GABA, glutamate, dopamine, glycine, serotonin, and voltage sensitive calcium channels. Thus this analysis did not reveal a genetic signature consistent with processes previously shown to be involved in toluene-induced narcosis in mammals. The list of the human orthologs included Gene Ontology terms associated with signaling, nervous system development and embryonic morphogenesis; these orthologs may provide insight into potential new pathways that could mediate the narcotic effects of toluene. C1 [Bushnell, Philip J.; Ward, William O.; Oshiro, Wendy M.; Hester, Susan D.; Mckee, John M.; Higuchi, Mark] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Morozova, Tatiana V.] North Carolina State Univ, Dept Biol Sci, Raleigh, NC USA. [Lin, Mimi T.] Oak Ridge Inst Sci & Engn, Oak Ridge, TN USA. [Judson, Richard S.] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA. RP Bushnell, PJ (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. EM pjbushnell33@gmail.com FU U.S. Environmental Protection Agency; NIH [R01 AA016560] FX The authors thank Drs Matthew Rand and William Boyes for reviews and comments on an early draft of this report. We also thank Drs Trudy F.C. Mackay and Wen Huang of North Carolina State University for the concept of the DGRP, support of the project, selecting the lines to test, and cultures of DGRP flies. Drs William Boyes and B.J. George of the EPA, and Jorge Muniz-Ortiz, now at the USDA, provided advice and consultation along the way. Dr Katoria Tatum-Gibbs, now at BASF, set up the fly laboratory at the EPA and generated dose-effect data for toluene. Dr James Mason of NIEHS provided invaluable advice and protocols regarding fly husbandry, and arranged for the media kitchen at NIEHS to provide glassware and fly medium, which was ably prepared by Jennie Foushee and Essie Jones. This work was funded by the U.S. Environmental Protection Agency and NIH R01 AA016560. NR 41 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD MAR PY 2017 VL 156 IS 1 BP 230 EP 239 DI 10.1093/toxsci/kfw243 PG 10 WC Toxicology SC Toxicology GA EO9ZR UT WOS:000397047100021 PM 28013218 ER PT J AU Das, KP Wood, CR Lin, MMT Starkov, AA Lau, C Wallace, KB Corton, JC Abbott, BD AF Das, Kaberi P. Wood, Carmen R. Lin, Mimi T. Starkov, Anatoly A. Lau, Christopher Wallace, Kendall B. Corton, J. Christopher Abbott, Barbara D. TI Perfluoroalkyl acids-induced liver steatosis: Effects on genes controlling lipid homeostasis SO TOXICOLOGY LA English DT Article DE Perfluorooctanoic acid; Perfluorooctane sulfonate; Perfluorononanoic acid; Perfluorohexane sulfonate; Steatosis; Triglycerides ID ACTIVATED RECEPTOR-ALPHA; LOW-DENSITY LIPOPROTEINS; APOLIPOPROTEIN C-II; INDUCED FATTY LIVER; PPAR-ALPHA; PERFLUOROOCTANOIC ACID; HEPATIC STEATOSIS; NUCLEAR RECEPTORS; BETA-OXIDATION; MITOCHONDRIAL BIOGENESIS AB Persistent presence of perfluoroalkyl acids (PFAAs) in the environment is due to their extensive use in industrial and consumer products, and their slow decay. Biochemical tests in rodent demonstrated that these chemicals are potent modifiers of lipid metabolism and cause hepatocellular steatosis. However, the molecular mechanism of PFAAs interference with lipid metabolism remains to be elucidated. Currently, two major hypotheses are that PFAAs interfere with mitochondria] beta-oxidation of fatty acids and/or they affect the transcriptional activity of peroxisome proliferator-activated receptor a (PPARa) in liver. To determine the ability of structurally-diverse PFAAs to cause steatosis, as well as to understand the underlying molecular mechanisms, wild-type (WT) and PPAR alpha-null mice were treated with perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), or perfluorohexane sulfonate (PFHxS), by oral gavage for 7 days, and their effects were compared to that of PPARa agonist WY-14643 (WY), which does not cause steatosis. Increases in liver weight and cell size, and decreases in DNA content per mg of liver, were observed for all compounds in WT mice, and were also seen in PPARa-null mice for PFOA, PFNA, and PFHxS, but not for WY. In Oil Red 0 stained sections, WT liver showed increased lipid accumulation in all treatment groups, whereas in PPAR alpha-null livers, accumulation was observed after PFNA and PFHxS treatment, adding to the burden of steatosis observed in control (untreated) PPARa-null mice. Liver triglyceride (TG) levels were elevated in WT mice by all PFAAs and in PPARa-null mice only by PFNA. In vitro beta-oxidation of palmitoyl carnitine by isolated rat liver mitochondria was not inhibited by any of the 7 PFAAs tested. Likewise, neither PFOA nor PFOS inhibited palmitate oxidation by HepG2/C3A human liver cell cultures. Microarray analysis of livers from PFAAs-treated mice indicated that the PFAAs induce the expression of the lipid catabolism genes, as well as those involved in fatty acid and triglyceride synthesis, in WT mice and, to a lesser extent, in PPARa-null mice. These results indicate that most of the PFAAs increase liver TG load and promote steatosis in mice We hypothesize that PFAAs increase steatosis because the balance of fatty acid accumulation/synthesis and oxidation is disrupted to favor accumulation.(C) Published by Elsevier Ireland Ltd. C1 [Das, Kaberi P.; Wood, Carmen R.; Lin, Mimi T.; Lau, Christopher; Abbott, Barbara D.] US EPA, Toxic Assessment Div, Natl Hlth & Environm Effects Res Lab, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. [Starkov, Anatoly A.; Wallace, Kendall B.] Univ Minnesota, Dept Biomed Sci, Sch Med, Duluth, MN 55812 USA. [Corton, J. Christopher] US EPA, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. RP Abbott, BD (reprint author), US EPA, Mail Code B105-04,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM abbott.barbara@epa.gov FU U.S. Environmental Protection Agency; 3 M Co. FX This study was carried out as part of the EPA steatosis AOP project within the Chemical Safety for Sustainability (CSS) Program. The information in this document has been funded by the U.S. Environmental Protection Agency. It has been subjected to review by the National Health and Environmental Effects Research Laboratory and approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. The work by KBW and AAS was supported by a grant from the 3 M Co. We thank Dr. Mitch Rosen for his valuable suggestions, and Drs. Brian Chorley, and Urmila Kodavanti for critical review of the manuscript. NR 76 TC 0 Z9 0 U1 5 U2 5 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0300-483X J9 TOXICOLOGY JI Toxicology PD MAR 1 PY 2017 VL 378 BP 37 EP 52 DI 10.1016/j.tox.2016.12.007 PG 16 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA EL3YS UT WOS:000394557200005 PM 28049043 ER PT J AU Porter, PS Rao, ST Hogrefe, C Mathur, R AF Porter, P. Steven Rao, S. T. Hogrefe, Christian Mathur, Rohit TI A reduced form model for ozone based on two decades of CMAQ simulations for the continental United States SO ATMOSPHERIC POLLUTION RESEARCH LA English DT Article DE Reduced form model; Ozone; Emissions; Meteorology; Community multiscale air quality model ID EMISSIONS; SYSTEM AB A Reduced Form Model (RFM) is a mathematical relationship between the inputs and outputs of an air quality model, permitting estimation of additional modeling without costly new regional-scale simulations. A 21-year Community Multiscale Air Quality (CMAQ) simulation for the continental United States provided the basis for the RFM developed in this study. Predictors included the principal component scores (PCS) of emissions and meteorological variables, while the predictand was the monthly mean of daily maximum 8-h CMAQ ozone for the ozone season at each model grid. The PCS form an orthogonal basis for RFM inputs. A few PCS incorporate most of the variability of emissions and meteorology, thereby reducing the dimensionality of the source-receptor problem. Stochastic kriging was used to estimate the model. The RFM was used to separate the effects of emissions and meteorology on ozone concentrations. By running the RFM with emissions constant (ozone dependent on meteorology), or constant meteorology (ozone dependent on emissions). Years with ozone-conducive meteorology were identified, and meteorological variables best explaining meteorology-dependent ozone were identified. Meteorology accounted for 19%-55% of ozone variability in the eastern US, and 39%-92% in the western US. Temporal trends estimated for original CMAQ ozone data and emission-dependent ozone were mostly negative, but the confidence intervals for emission-dependent ozone are much narrower. Emission-driven changes in monthly mean ozone levels for the period 2000-2010 ranged from 6.4 to 10.9 ppb for the eastern US and from 1.4 to 2.5 ppb for the western US. Copyright (C) 2017 Turkish National Committee for Air Pollution Research and Control. Production and hosting by Elsevier B.V. All rights reserved. C1 [Porter, P. Steven] Porter Gego, Idaho Falls, ID USA. [Rao, S. T.] North Carolina State Univ, Raleigh, NC 27695 USA. [Hogrefe, Christian; Mathur, Rohit] US EPA, AMAD NERI, Res Triangle Pk, NC USA. RP Porter, PS (reprint author), 308 Evergreen Dr, Idaho Falls, ID 83401 USA. EM pporter@uidaho.edu FU Coordinating Research Council [A-89] FX Although this paper has been reviewed and approved for publication by the U.S. Environmental Protection Agency, it does not necessarily reflect the Agency's views or policies. One of the authors (P.S. Porter) acknowledges the support from the Coordinating Research Council under contract A-89. NR 21 TC 0 Z9 0 U1 0 U2 0 PU TURKISH NATL COMMITTEE AIR POLLUTION RES & CONTROL-TUNCAP PI BUCA PA DOKUZ EYLUL UNIV, DEPT ENVIRONMENTAL ENGINEERING, TINAZTEPE CAMPUS, BUCA, IZMIR 35160, TURKEY SN 1309-1042 J9 ATMOS POLLUT RES JI Atmos. Pollut. Res. PD MAR PY 2017 VL 8 IS 2 BP 275 EP 284 DI 10.1016/j.apr.2016.09.005 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA EP5RF UT WOS:000397435600007 ER PT J AU Kamel, A Tomasino, SF AF Kamel, Alaa Tomasino, Stephen F. TI Analytical Method for the Detection of Residual Active Ingredients Found in Neutralized Suspensions of Antimicrobial Products SO JOURNAL OF AOAC INTERNATIONAL LA English DT Article ID LIQUID-CHROMATOGRAPHY AB An analytical method for determining the presence and levels of residual active ingredients found in neutralized suspensions of phenolic and quaternary ammonium salt-based antimicrobial products was developed using solid-phase extraction in combination with LC-tandem MS. A single-laboratory validation of the method was performed at three concentration levels for the quaternary ammonium compounds (also referred to as benzalkonium chlorides or BACs) and the phenols in the presence of letheen broth neutralizer at 2.5 and 2.75 mu g/mL, respectively, as well as at dilutions of 1:10 and 1:100 in those concentrations. The method's lowest LODs were 0.005 mu g/g for BACs and 0.006 mu g/g for phenols. The average recovery of the fortified samples for both active ingredients ranged between 80 and 124%, and RSDs were generally <20%. In a related study, the effectiveness of letheen broth with and without sodium thiosulfate was evaluated as a neutralizer for sodium hypochlorite. The results showed that letheen broth without sodium thiosulfate neutralizes chlorine concentrations up to 60 ppm, and that 200 mu g sodium thiosulfate are required to neutralize a 72 ppm concentrated chlorine solution in letheen broth. C1 [Kamel, Alaa] US EPA, Off Pesticide Programs, Biol & Econ Anal Div, Analyt Chem Branch, 701 Mapes Rd, Ft George G Meade, MD 20755 USA. [Tomasino, Stephen F.] US EPA, Off Pesticide Programs, Biol & Econ Anal Div, Microbiol Lab Branch, 701 Mapes Rd, Ft George G Meade, MD 20755 USA. RP Kamel, A (reprint author), US EPA, Off Pesticide Programs, Biol & Econ Anal Div, Analyt Chem Branch, 701 Mapes Rd, Ft George G Meade, MD 20755 USA. EM kamel.alaa@epa.gov NR 13 TC 0 Z9 0 U1 0 U2 0 PU AOAC INT PI GAITHERSBURG PA 481 N FREDRICK AVE, STE 500, GAITHERSBURG, MD 20877-2504 USA SN 1060-3271 EI 1944-7922 J9 J AOAC INT JI J. AOAC Int. PD MAR-APR PY 2017 VL 100 IS 2 BP 387 EP 391 DI 10.5740/jaoacint.16-0244 PG 5 WC Chemistry, Analytical; Food Science & Technology SC Chemistry; Food Science & Technology GA EN4HW UT WOS:000395969600011 PM 28118571 ER PT J AU Swanson, S Kozlowski, D Hall, R Heggem, D Lin, J AF Swanson, S. Kozlowski, D. Hall, R. Heggem, D. Lin, J. TI Riparian proper functioning condition assessment to improve watershed management for water quality SO JOURNAL OF SOIL AND WATER CONSERVATION LA English DT Editorial Material DE environmental indicators; function; nutrients; rivers and streams; sediment; temperature ID COASTAL-PLAIN; BEAVER DAMS; TEMPORAL VARIABILITY; GEOMORPHIC PROCESSES; ECOSYSTEM SERVICES; CHANNEL MORPHOLOGY; FLUVIAL LANDFORMS; RIVER CORRIDORS; NORTH-CAROLINA; BANK EROSION AB Pollutants can be reduced, ameliorated or assimilated when riparian ecosystems have the vegetation, water, and soil/landform needed for riparian functions. Loss of physical form and ecological function unravels assimilation processes, increasing supply and transport of pollutants. Water quality and aquatic organisms are response measures of accumulated upstream discharges, and ultimately of changes in riparian functions. Thus, water quality monitoring often fails to identify or lags behind many causes of pollution or remediation from riparian degradation. This paper reviews the interagency riparian proper functioning condition (PFC) assessment for lotic (running water) riparian ecosystems and outlines connections between PFC and water quality attributes (sediment, nutrients, temperature, and dissolved oxygen [DO]). The PFC interaction of hydrology, vegetation, and soils/landforms influences water quality by dissipating energy associated with high waterflow, thereby reducing vertical instability and lateral erosion while developing floodplains with captured sediment and nutrients. Slowing flood water enables aquifer recharge, deposition, and plant nutrient uptake. Water-loving, densely rooted streambank stabilizing vegetation and/or wood helps integrate riparian functions to maintain channel pattern, profile, and dimension with characteristics for a diversity of habitats. A complex food web helps slow the nutrient spiral with uptake and storage. Temperature fluctuations are dampened by delayed discharges, narrower and deeper active channels, coarser substrates that enhance hyporheic interchange, and shade from riparian vegetation. After assessment and implementation, monitoring recovery of impaired riparian function attributes (e.g., streambank plant species) naturally focuses on persistent drivers of water quality and aquatic habitat. This provides timely environmental indicators of stream ecological health and water quality remediation projects or land management. C1 [Swanson, S.] Univ Nevada, Dept Agr Nutr & Vet Sci, Reno, NV 89557 USA. [Kozlowski, D.] US Forest Serv, Sequoia Natl Forest, Western Divide Ranger Dist, Springville, CA USA. [Hall, R.] US EPA, San Francisco, CA USA. [Heggem, D.; Lin, J.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Div Environm Sci, Las Vegas, NV 89193 USA. RP Swanson, S (reprint author), Univ Nevada, Dept Agr Nutr & Vet Sci, Reno, NV 89557 USA. FU US Environmental Protection Agency under Student Services Contract [EP09D000249] FX The information in this document has been funded in part by the US Environmental Protection Agency under Student Services Contract number EP09D000249 to Don Kozlowski while a student at the University of Nevada, Reno. NR 155 TC 0 Z9 0 U1 0 U2 0 PU SOIL WATER CONSERVATION SOC PI ANKENY PA 945 SW ANKENY RD, ANKENY, IA 50023-9723 USA SN 0022-4561 EI 1941-3300 J9 J SOIL WATER CONSERV JI J. Soil Water Conserv. PD MAR-APR PY 2017 VL 72 IS 2 BP 168 EP 182 DI 10.2489/jSWC.72.2.168 PG 15 WC Ecology; Soil Science; Water Resources SC Environmental Sciences & Ecology; Agriculture; Water Resources GA EN4DL UT WOS:000395957900013 ER PT J AU Ivask, A Scheckel, KG Kapruwan, P Stone, V Yin, H Voelcker, NH Lombi, E AF Ivask, Angela Scheckel, Kirk G. Kapruwan, Pankaj Stone, Vicki Yin, Hong Voelcker, Nicolas H. Lombi, Enzo TI Complete transformation of ZnO and CuO nanoparticles in culture medium and lymphocyte cells during toxicity testing SO NANOTOXICOLOGY LA English DT Article DE Copper oxide; zinc oxide; nanoparticles; speciation; mammalian cells ID METAL-OXIDE NANOPARTICLES; RAY-ABSORPTION SPECTROSCOPY; IN-VITRO; TEST ORGANISMS; CYTOTOXICITY; FATE; AG; GENOTOXICITY; DISSOLUTION; IONS AB Here, we present evidence on complete transformation of ZnO and CuO nanoparticles, which are among the most heavily studied metal oxide particles, during 24h in vitro toxicological testing with human T-lymphocytes. Synchrotron radiation-based X-ray absorption near edge structure (XANES) spectroscopy results revealed that Zn speciation profiles of 30nm and 80nm ZnO nanoparticles, and ZnSO4- exposed cells were almost identical with the prevailing species being Zn-cysteine. This suggests that ZnO nanoparticles are rapidly transformed during a standard in vitro toxicological assay, and are sequestered intracellularly, analogously to soluble Zn. Complete transformation of ZnO in the test conditions was further supported by almost identical Zn spectra in medium to which ZnO nanoparticles or ZnSO4 was added. Likewise, Cu XANES spectra for CuO and CuSO4-exposed cells and cell culture media were similar. These results together with our observation on similar toxicological profiles of ZnO and soluble Zn, and CuO and soluble Cu, underline the importance of dissolution and subsequent transformation of ZnO and CuO nanoparticles during toxicological testing and provide evidence that the nano-specific effect of ZnO and CuO nanoparticles is negligible in this system. We strongly suggest to account for this aspect when interpreting the toxicological results of ZnO and CuO nanoparticles. C1 [Ivask, Angela; Kapruwan, Pankaj; Voelcker, Nicolas H.; Lombi, Enzo] Univ South Australia, Future Ind Inst, Mawson Lakes, SA 5095, Australia. [Scheckel, Kirk G.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Stone, Vicki] Heriot Watt Univ, Edinburgh, Midlothian, Scotland. [Yin, Hong] CSIRO Mfg, Clayton, Vic, Australia. [Ivask, Angela] NICPB, Lab Environm Toxicol, Tallinn, Estonia. RP Lombi, E (reprint author), Univ South Australia, Future Ind Inst, Mawson Lakes, SA 5095, Australia. EM EnzoLombi@unisa.du.au FU SA Government PRIF program project "International Cluster on Nanosafety"; SUN project - European Commission [604305]; Alexander von Humboldt Fellowship for Experienced Researchers; Estonian Research Council [PUT748]; SA Archimedes EQUiTANT; DOE Office of Science [DE-AC02-06CH11357] FX Financial support from SA Government PRIF program project "International Cluster on Nanosafety" and SUN project Funded by the European Commission (Grant agreement no. 604305) are kindly acknowledged. N.H.V. holds an Alexander von Humboldt Fellowship for Experienced Researchers. A. I is currently funded by Estonian Research Council grants PUT748 and SA Archimedes EQUiTANT. Although EPA contributed to this article, the views, interpretations, and conclusions expressed in this article are solely those of the authors and do not necessarily reflect or represent EPA's views or policies. This research used resources of the Department of Energy and the MRCAT member institutions, Advanced Photon Source, a U.S. Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under Contract No. DE-AC02-06CH11357. NR 22 TC 0 Z9 0 U1 3 U2 3 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 1743-5390 EI 1743-5404 J9 NANOTOXICOLOGY JI Nanotoxicology PD MAR PY 2017 VL 11 IS 2 BP 150 EP 156 DI 10.1080/17435390.2017.1282049 PG 7 WC Nanoscience & Nanotechnology; Toxicology SC Science & Technology - Other Topics; Toxicology GA EM5XV UT WOS:000395388200002 PM 28165880 ER PT J AU Rung, AL Gaston, S Robinson, WT Trapido, EJ Peters, ES AF Rung, Ariane L. Gaston, Symielle Robinson, William T. Trapido, Edward J. Peters, Edward S. TI Untangling the disaster-depression knot: The role of social ties after Deepwater Horizon SO SOCIAL SCIENCE & MEDICINE LA English DT Article DE Louisiana, USA; Social support; Cognitive social capital; Structural social capital; Mental health; Disaster; Oil spill; Structural equation modeling ID VALDEZ OIL-SPILL; QUALITY-OF-LIFE; MENTAL-HEALTH; EXXON-VALDEZ; PSYCHOLOGICAL IMPACTS; SUPPORT; STRESS; MULTILEVEL; WOMEN; MODEL AB The mental health consequences of disasters, including oil spills, are well known. The goal of this study is to examine whether social capital and social support mediate the effects of exposure to the Deepwater Horizon oil spill on depression among women. Data for the analysis come from the first wave of data collection for the Women and Their Children's Health Study, a longitudinal study of the health effects of women exposed to the oil spill in southern Louisiana, USA. Women were interviewed about their exposure to the oil spill, depression symptoms, structural social capital (neighborhood organization participation), cognitive social capital (sense of community and informal social control), and social support. Structural equation models indicated that structural social capital was associated with increased levels of cognitive social capital, which were associated with higher levels of social support, which in turn were associated with lower levels of depression. Physical exposure to the oil spill was associated with greater economic exposure, which in turn was associated with higher levels of depression. When all variables were taken into account, economic exposure was no longer associated with depression, and social support and cognitive social capital mediated the effect of economic exposure on depression, explaining 67% of the effect. Findings support an extension of the deterioration model of social support to include the additional coping resource of social capital. Social capital and social support were found to be beneficial for depression post-oil spill; however, they were themselves negatively impacted by the oil spill, explaining the overall negative effect of the oil spill on depression. A better understanding of the pathways between the social context and depression could lead to interventions for improved mental health in the aftermath of a disaster. (C) 2017 Elsevier Ltd. All rights reserved. C1 [Rung, Ariane L.; Gaston, Symielle; Trapido, Edward J.; Peters, Edward S.] Louisiana State Univ, Hlth Sci Ctr, Sch Publ Hlth, Program Epidemiol, 2020 Gravier St,3rd Floor, New Orleans, LA 70118 USA. [Robinson, William T.] Louisiana State Univ, Hlth Sci Ctr, Sch Publ Hlth, Behav & Community Hlth Sci Program, 2020 Gravier St,3rd floor, New Orleans, LA 70118 USA. [Gaston, Symielle] US Environm Protect Agcy, Off Res & Dev, Oak Ridge Inst Sci, Natl Exposure Res Lab, Res Triangle Pk, NC USA. [Gaston, Symielle] US Environm Protect Agcy, Off Res & Dev, Natl Exposure Res Lab, Educ Res Participat Program, Res Triangle Pk, NC USA. RP Rung, AL (reprint author), Louisiana State Univ, Hlth Sci Ctr, Sch Publ Hlth, Program Epidemiol, 2020 Gravier St,3rd Floor, New Orleans, LA 70118 USA. EM abedim@isuhsc.edu; wrobin@lsuhsc.edu; etrapi@lsuhsc.edu; epetel@lsuhsc.edu OI Rung, Ariane/0000-0002-1372-1902 FU National Institute of Environmental Health Sciences, National Institutes of Health [1U01ES021497]; Substance Abuse and Mental Health Services Administration grant [3U01ES021497-03S1] FX This research was supported by the National Institute of Environmental Health Sciences, National Institutes of Health (grant 1U01ES021497) and Substance Abuse and Mental Health Services Administration (grant 3U01ES021497-03S1). NR 45 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0277-9536 J9 SOC SCI MED JI Soc. Sci. Med. PD MAR PY 2017 VL 177 BP 19 EP 26 DI 10.1016/j.socscimed.2017.01.041 PG 8 WC Public, Environmental & Occupational Health; Social Sciences, Biomedical SC Public, Environmental & Occupational Health; Biomedical Social Sciences GA EP7JA UT WOS:000397552900003 PM 28152421 ER PT J AU Davis, JM Ekman, DR Skelton, DM LaLone, CA Ankley, GT Cavallin, JE Villeneuve, DL Collette, TW AF Davis, J. M. Ekman, D. R. Skelton, D. M. LaLone, C. A. Ankley, G. T. Cavallin, J. E. Villeneuve, D. L. Collette, T. W. TI Metabolomics for informing adverse outcome pathways: Androgen receptor activation and the pharmaceutical spironolactone SO AQUATIC TOXICOLOGY LA English DT Article DE Metabolomics; Fathead minnow; Mineralocorticoid; Reproduction ID MINNOW PIMEPHALES-PROMELAS; L-CARNITINE SUPPLEMENTATION; MINERALOCORTICOID RECEPTOR; FATHEAD MINNOW; POECILIA-RETICULATA; FISH; EXPOSURE; METABOLISM; 17-BETA-TRENBOLONE; CORTICOSTERONE AB One objective in developing adverse outcome pathways (AOPs) is to connect biological changes that are relevant to risk assessors (i.e., fecundity) to molecular and cellular-level alterations that might be detectable at earlier stages of a chemical exposure. Here, we examined biochemical responses of fathead minnows (Pimephales promelas) to inform an AOP relevant to spironolactone's activation of the androgen receptor, as well as explore other biological impacts possibly unrelated to this receptor. Liquid chromatography with high resolution mass spectrometry (LC-MS) was used to measure changes in endogenous polar metabolites in livers of male and female fish that were exposed to five water concentrations of spironolactone (0, 0.05, 0.5. 5, or 50 mu g L-1) for 21 days. Metabolite profiles were affected at the two highest concentrations (5 and 50 mu g L-1), but not in the lower-level exposures, which agreed with earlier reported results of reduced female fecundity and plasma vitellogenin (VTG) levels. We then applied partial least squares regression to assess whether metabolite alterations covaried with changes in fecundity, VTG gene expression and protein concentrations, and plasma 17 beta-estradiol and testosterone concentrations. Metabolite profiles significantly covaried with all measured endpoints in females, but only with plasma testosterone in males. Fecundity reductions occurred in parallel with changes in metabolites important in osmoregulation (e.g., betaine), membrane transport (e.g., L-carnitine), and biosynthesis of carnitine (e.g., methionine) and VTG (e.g., glutamate). Based on a network analysis program (i.e., mummichog), spironolactone also affected amino acid, tryptophan, and fatty acid metabolism. Thus, by identifying possible key events related to changes in biochemical pathways, this approach built upon an established AOP describing spirono-lactone's androgenic properties and highlighted broader implications potentially unrelated to androgen receptor activation, which could form a basis for the development of an AOP network. Published by Elsevier B.V. C1 [Davis, J. M.; Ekman, D. R.; Skelton, D. M.; Collette, T. W.] US EPA, Natl Exposure Res Lab, 960 Coll Stn Rd, Athens, GA 30605 USA. [LaLone, C. A.; Ankley, G. T.; Cavallin, J. E.; Villeneuve, D. L.] US EPA, Natl Hlth & Environm Effects Res Lab, 6201 Congdon Blvd, Duluth, MN 55804 USA. [Davis, J. M.] US EPA, Water Protect Div, Reg 4,61 Forsyth St SW, Atlanta, GA 30303 USA. [Skelton, D. M.] US FDA, 6751 Steger Dr, Cincinnati, OH 45237 USA. RP Davis, JM; Ekman, DR (reprint author), US EPA, Natl Exposure Res Lab, 960 Coll Stn Rd, Athens, GA 30605 USA.; Davis, JM (reprint author), US EPA, Water Protect Div, Reg 4,61 Forsyth St SW, Atlanta, GA 30303 USA. EM davis.john@epa.gov; ekman.drew@epa.gov FU Great Lakes National Program Office; ORISE Fellowship FX We thank E. Durhan, M. Hughes, K. Jensen, M. Kahl, E. Makynen, S. Skolness, and K. Stevens for technical assistance, and T. Smith for research support. J. Mosley provided advice on processing of LC-MS/MS data. J. Davis was supported by the Great Lakes National Program Office and an appointment to the Postdoctoral Research Program at the National Exposure Research Laboratory, administered by Oak Ridge Institute for Science and Education (ORISE) through interagency agreement between US Department of Energy and Environmental Protection Agency (EPA). J. Cavallin was also supported by an ORISE Fellowship. Views expressed in this article are those of the authors and do not necessarily represent views or policies of the US EPA. Mention of products or trade names does not indicate endorsement of by US EPA. NR 59 TC 0 Z9 0 U1 2 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-445X EI 1879-1514 J9 AQUAT TOXICOL JI Aquat. Toxicol. PD MAR PY 2017 VL 184 BP 103 EP 115 DI 10.1016/j.aquatox.2017.01.001 PG 13 WC Marine & Freshwater Biology; Toxicology SC Marine & Freshwater Biology; Toxicology GA EM9CO UT WOS:000395608900009 PM 28129603 ER PT J AU Steinberg, S Hodge, V Schumacher, B Sovocool, W AF Steinberg, Spencer Hodge, Vernon Schumacher, Brian Sovocool, Wayne TI Sampling for silver nanoparticles in aqueous media using a rotating disk electrode: evidence for selective sampling of silver nanoparticles in the presence of ionic silver SO ENVIRONMENTAL MONITORING AND ASSESSMENT LA English DT Article DE Silver nanoparticles; Voltammetry; Anodic stripping; Rotating disk; Carbon paste electrode ID ANODIC-STRIPPING VOLTAMMETRY; PLASMA-MASS SPECTROMETRY; GOLD; SIZE AB Amendment of a carbon paste electrode consisting of graphite and Nujol (R), with a variety of organic and inorganic materials, allows direct adsorption of silver nanoparticles (AgNPs) from aqueous solution in either open or close circuit modes. The adsorbed AgNPs are detected by stripping voltammetry. Detection limits of less than 1 ppb Ag are achievable with a rotating disk system. More than one silver peak was apparent in many of the stripping voltammograms. The appearance of multiple peaks could be due to different species of silver formed upon stripping or variation in the state of aggregation or size of nanoparticles. With most of these packing materials, dissolved Ag+ was also extracted from aqueous solution, but, with a packing material made with Fe(II,III) oxide nanoparticles, only AgNPs were extracted. Therefore, it is the best candidate for determination of metallic AgNPs in aqueous environmental samples without interference from Ag+. C1 [Steinberg, Spencer; Hodge, Vernon] Univ Nevada, Dept Chem, Las Vegas, NV 89154 USA. [Schumacher, Brian; Sovocool, Wayne] US EPA, Natl Exposure Res Lab, Las Vegas, NV 89119 USA. RP Steinberg, S (reprint author), Univ Nevada, Dept Chem, Las Vegas, NV 89154 USA. EM spencer.steinberg@unlv.edu FU US Environmental Protection Agency through its Office of Research and Development [EP-11-D-1618] FX The US Environmental Protection Agency through its Office of Research and Development funded, managed, and collaborated in the research described here under contract EP-11-D-1618 to the University of Nevada, Las Vegas. It has been subjected to agency review and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 18 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0167-6369 EI 1573-2959 J9 ENVIRON MONIT ASSESS JI Environ. Monit. Assess. PD MAR PY 2017 VL 189 IS 3 AR 99 DI 10.1007/s10661-017-5809-6 PG 13 WC Environmental Sciences SC Environmental Sciences & Ecology GA EM0IA UT WOS:000395000800006 PM 28176261 ER PT J AU Eckley, CS Luxton, TP Goetz, J McKernan, J AF Eckley, Chris S. Luxton, Todd P. Goetz, Jennifer McKernan, John TI Water-level fluctuations influence sediment porewater chemistry and methylmercury production in a flood-control reservoir SO ENVIRONMENTAL POLLUTION LA English DT Article DE Porewater; Mercury methylation; Reservoir; Water-level; DOC ID MERCURY METHYLATION; PRINCIPAL METHYLATORS; REDUCING BACTERIA; MARINE-SEDIMENTS; UNITED-STATES; YELLOW PERCH; FRESH-WATER; PORE-WATER; HOT-SPOTS; FISH AB Reservoirs typically have elevated fish mercury (Hg) levels compared to natural lakes and rivers. A unique feature of reservoirs is water-level management which can result in sediment exposure to the air. The objective of this study is to identify how reservoir water-level fluctuations impact Hg cycling, particularly the formation of the more toxic and bioaccumulative methylmercury (MeHg). Total-Hg (THg), MeHg, stable isotope methylation rates and several ancillary parameters were measured in reservoir sediments (including some in porewater and overlying water) that are seasonally and permanently inundated. The results showed that sediment and porewater MeHg concentrations were over 3-times higher in areas experiencing water-level fluctuations compared to permanently inundated sediments. Analysis of the data suggest that the enhanced breakdown of organic matter in sediments experiencing water-level fluctuations has a two-fold effect on stimulating Hg methylation: 1) it increases the partitioning of inorganic Hg from the solid phase into the porewater phase (lower log K-d values) where it is more bioavailable for methylation; and 2) it increases dissolved organic carbon (DOC) in the porewater which can stimulate the microbial community that can methylate Hg. Sulfate concentrations and cycling were enhanced in the seasonally inundated sediments and may have also contributed to increased MeHg production. Overall, our results suggest that reservoir management actions can have an impact on the sediment-porewater characteristics that affect MeHg production. Such findings are also relevant to natural water systems that experience wetting and drying cycles, such as floodplains and ombrotrophic wetlands. C1 [Eckley, Chris S.] US EPA, Reg 10 1200,6th Ave, Seattle, WA 98101 USA. [Luxton, Todd P.; Goetz, Jennifer; McKernan, John] US EPA, Off Res & Dev, Natl Risk Management Res Lab, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA. RP Luxton, TP (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA. EM luxton.todd@epa.gov NR 59 TC 0 Z9 0 U1 3 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0269-7491 EI 1873-6424 J9 ENVIRON POLLUT JI Environ. Pollut. PD MAR PY 2017 VL 222 BP 32 EP 41 DI 10.1016/j.envPo1.2017.01.010 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA EM5OJ UT WOS:000395360900004 PM 28104341 ER PT J AU Leow, A Burkhardt, J Platten, WE Zimmerman, B Brinkman, NE Turner, A Murray, R Sorial, G Garland, J AF Leow, Aaron Burkhardt, Jonathan Platten, William E., III Zimmerman, Brian Brinkman, Nichole E. Turner, Anne Murray, Regan Sorial, George Garland, Jay TI Application of the CANARY event detection software for real-time performance monitoring of decentralized water reuse systems SO ENVIRONMENTAL SCIENCE-WATER RESEARCH & TECHNOLOGY LA English DT Article ID WASTE-WATER; MEMBRANE PROCESSES; REMOVAL; CONTAMINATION; INDICATORS; VIRUSES; RISKS AB Real-time monitoring of water reuse systems ensures the production of high quality water to protect human health at the point-of-use. In this study, several online real-time sensors were utilized to monitor effluent from a wastewater fed laboratory-scale membrane bioreactor (MBR) under natural and simulated failure conditions. These simulated failures included adding reactor mixed liquor to emulate a membrane breach, and spiking MS2 bacteriophage into the reactor to create a high viral load, which might be observed during an outbreak. The CANARY event detection software was used to analyze sensor data and report changes in water quality that might be indicative of poor system behavior. During simulated failure conditions, CANARY reported 20 alarms, accurately detecting each failure. During natural operating conditions, 219 alarms were produced and 189 were attributed to known events (e.g., system and sensor maintenance). The remaining alarms (23) during natural operating conditions were considered to have an unknown cause. However, 13 of those had signal deviations similar to known events, but could not be definitively linked to a source. The results of this study suggest that real-time monitoring in conjunction with CANARY analysis may be useful as an early warning system for monitoring the effluent of water reuse systems, and may help to quickly identify treatment malfunctions or other abnormal conditions. C1 [Leow, Aaron; Sorial, George] Univ Cincinnati, Dept Biomed Chem & Environm Engn, 2901 Woodside Dr, Cincinnati, OH 45221 USA. [Burkhardt, Jonathan; Murray, Regan] US EPA, Natl Homeland Secur Res Ctr, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. [Platten, William E., III] Pegasus Tech Serv Inc, 46 E Hollister St, Cincinnati, OH 45219 USA. [Zimmerman, Brian; Turner, Anne] US EPA, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. [Brinkman, Nichole E.; Garland, Jay] US EPA, Syst Exposure Div, Natl Exposure Res Lab, 26 W Martin Luther King Dr,MS 587, Cincinnati, OH 45268 USA. RP Brinkman, NE (reprint author), US EPA, Syst Exposure Div, Natl Exposure Res Lab, 26 W Martin Luther King Dr,MS 587, Cincinnati, OH 45268 USA. EM brinkman.nichole@epa.gov FU U.S. Environmental Protection Agency through its Office of Research and Development; Pegasus Technical Services, Inc.; University of Cincinnati [EP-C-11-006, 82]; Internship/Research Participation Program at the National Homeland Security Research Center; Water Infrastructure Protection Division; U.S. Environmental Protection Agency FX The U.S. Environmental Protection Agency through its Office of Research and Development funded and managed the research described here.; Support for the research was provided by Pegasus Technical Services, Inc. along with the University of Cincinnati through contract EP-C-11-006 Work Assignment 82.; Additionally, this project was supported in part by an appointment to the Internship/Research Participation Program at the National Homeland Security Research Center, Water Infrastructure Protection Division, U.S. Environmental Protection Agency, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and EPA. NR 34 TC 0 Z9 0 U1 0 U2 0 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2053-1400 EI 2053-1419 J9 ENVIRON SCI-WAT RES JI Environ. Sci.-Wat. Res. Technol. PD MAR 1 PY 2017 VL 3 IS 2 BP 224 EP 234 DI 10.1039/c6ew00226a PG 11 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA EN4UO UT WOS:000396002600004 ER PT J AU Norton, SB Schofield, KA AF Norton, Susan B. Schofield, Kate A. TI Conceptual model diagrams as evidence scaffolds for environmental assessment and management SO FRESHWATER SCIENCE LA English DT Article DE conceptual models; evidence; environmental assessment; evidence synthesis; literature-based; mountaintop; removal mining. ID KNOWLEDGE MAPS; ECOLOGICAL RISK; USA; DISPLAYS; TEXT; OHIO AB Sound environmental management relies on scientific evidence to indicate whether action is warranted and, if so, which actions will be most effective. We discuss conceptual model diagrams that schematically describe how sources or human activities lead to specific stressors and ultimately to biotic effects. They are useful for describing how undesirable effects are produced and identifying where management actions may be most effective in preventing unwanted effects or improving existing conditions. We illustrate the use of conceptual model diagrams in a literature -based assessment of the impacts of mountaintop removal mining on downstream aquatic systems. The diagram-development process combined extraction and evaluation of research results with iterative refinement of diagrams depicting source-to-stressor-to-effect causal pathways. Conceptual -model diagrams provided a useful scaffold for organizing and synthesizing multiple individual pieces of evidence extracted from different studies and an effective way to summarize and present the evidentiary foundation of the assessment's conclusions. Key words: conceptual models, evidence, environmental assessment, evidence synthesis, literature -based, mountaintop removal mining. C1 [Norton, Susan B.; Schofield, Kate A.] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Washington, DC 20460 USA. RP Norton, SB (reprint author), US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Washington, DC 20460 USA. EM norton.susan@epa.gov; schofield.kate@epa.gov NR 39 TC 2 Z9 2 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 2161-9549 EI 2161-9565 J9 FRESHW SCI JI Freshw. Sci. PD MAR PY 2017 VL 36 IS 1 BP 231 EP 239 DI 10.1086/690296 PG 9 WC Ecology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA EL5AJ UT WOS:000394633500019 ER PT J AU Webb, JA Schofield, K Peat, M Norton, SB Nichols, SJ Melcher, A AF Webb, J. Angus Schofield, Kate Peat, Michael Norton, Susan B. Nichols, Susan J. Melcher, Andreas TI Weaving common threads in environmental causal assessment methods: toward an ideal method for rapid evidence synthesis SO FRESHWATER SCIENCE LA English DT Article DE evidence-based practice; systematic literature review; rapid evidence synthesis; Eco Evidence; conceptual model diagrams; multiple lines of evidence ID SYSTEMATIC REVIEWS; MANAGEMENT DECISIONS AB Accurate and informative methods for evidence synthesis that are also simple and inexpensive to implement would greatly increase our ability to use scientific research results to better manage natural environments. Across the world, pressure to use evidence-based environmental management is increasing, but little guidance exists as to what 'evidence-based' actually means. Methods for systematic review of literature evidence have been modified from those used in medical research, but the effort involved in using these methods means that they have not been widely adopted. We compared 3 independently developed approaches to 'rapid evidence synthesis' methods developed in an attempt to improve efficiency and responsiveness compared to standard methods for systematic review. Each method has features that should be included in an ideal rapid evidence-synthesis method and has potential for further development. Increasing standardization of methods for evidence extraction, quality assessment, and synthesis increases the transparency and repeatability of the results obtained. However, the most important consideration is that the methods are fit for purpose; i.e., that each method is good enough to do the job required. The methods presented in this BRIDGES cluster, and potentially a combined method derived from them, could reduce the effort and cost of evidence synthesis to the scales required for management decisions. C1 [Webb, J. Angus] Univ Melbourne, Dept Infrastruct Engn, Melbourne, Vic 3010, Australia. [Schofield, Kate; Norton, Susan B.] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Arlington, VA 22202 USA. [Peat, Michael; Nichols, Susan J.] Univ Canberra, Inst Appl Ecol, Canberra, ACT 2617, Australia. [Melcher, Andreas] Univ Nat Resources & Life Sci BOKU, Dept Water Atmosphere & Environm, A-1180 Vienna, Austria. RP Webb, JA (reprint author), Univ Melbourne, Dept Infrastruct Engn, Melbourne, Vic 3010, Australia. EM angus.webb@unimelb.edu.au; schofield.kate@epa.gov; michael.peat@canberra.edu.au; norton.susan@epa.gov; sue.nichols@canberra.edu.au; andreas.melcher@boku.ac.at NR 29 TC 2 Z9 2 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 2161-9549 EI 2161-9565 J9 FRESHW SCI JI Freshw. Sci. PD MAR PY 2017 VL 36 IS 1 BP 250 EP 256 DI 10.1086/690449 PG 7 WC Ecology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA EL5AJ UT WOS:000394633500021 ER PT J AU Gibson, PP Mills, MA Kraus, JM Walters, DM AF Gibson, Polly P. Mills, Marc A. Kraus, Johanna M. Walters, David M. TI A Modeling Approach to Compare Sigma PCB Concentrations between Congener-Specific Analyses SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Article DE Congener-based analysis; Great Lakes Areas of Concern; Manistique River and Harbor; PCBs; Remedy effectiveness monitoring ID POLYCHLORINATED-BIPHENYLS; GREAT-LAKES; ORGANOCHLORINE PESTICIDES; FISH; SEDIMENTS; TRENDS; RIVER; PROFILES; PATTERNS; MICHIGAN AB Changes in analytical methods over time pose problems for assessing long-term trends in environmental contamination by PCBs. Congener-specific analyses vary widely in the number and identity of the 209 distinct PCB chemical configurations (congeners) that are quantified, leading to inconsistencies among summed PCB concentrations (Sigma PCB) reported by different studies. Here, we present a modeling approach using linear regression to compare Sigma PCB concentrations derived from different congener-specific analyses measuring different co-eluting groups. The approach can be used to develop a specific conversion model between any 2 sets of congener-specific analytical data from similar samples (similar matrix and geographic origin). We demonstrate the method by developing a conversion model for an example data set that includes data from 2 different analytical methods, a low resolution method quantifying 119 congeners and a high resolution method quantifying all 209 congeners. We used the model to show that the 119-congener set captured most (93%) of the total PCB concentration (i.e., Sigma 209PCB) in sediment and biological samples. Sigma PCB concentrations estimated using the model closely matched measured values (mean relative percent difference=9.6). General applications of the modeling approach include 1) generating comparable Sigma PCB concentrations for samples that were analyzed for different congener sets; and 2) estimating the proportional contribution of different congener sets to Sigma PCB. This approach may be especially valuable for enabling comparison of long-term remediation monitoring results even as analytical methods change over time. Integr Environ Assess Manag 2017;13:227-232. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. C1 [Gibson, Polly P.; Kraus, Johanna M.; Walters, David M.] US Geol Survey, Ft Collins Sci Ctr, Ft Collins, CO USA. [Mills, Marc A.] US Environm Protect Agcy, Natl Risk Management Res Lab, Cincinnati, OH USA. RP Walters, DM (reprint author), US Geol Survey, Ft Collins Sci Ctr, Ft Collins, CO USA. EM waltersd@usgs.gov FU US Environmental Protection Agency Great Lakes Restoration Initiative grant FX We thank A Mucha and S Cieniawski for contributing to different aspects of this project including study design and additional contractor support. This project was funded by a US Environmental Protection Agency Great Lakes Restoration Initiative grant to DMW. NR 23 TC 0 Z9 0 U1 0 U2 0 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD MAR PY 2017 VL 13 IS 2 BP 227 EP 232 DI 10.1002/ieam.1821 PG 6 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA EM0MM UT WOS:000395012400001 PM 27427154 ER PT J AU Matthiessen, P Ankley, GT Biever, RC Bjerregaard, P Borgert, C Brugger, K Blankinship, A Chambers, J Coady, KK Constantine, L Dang, Z Denslow, ND Dreier, DA Dungey, S Gray, LE Gross, M Guiney, PD Hecker, M Holbech, H Iguchi, T Kadlec, S Karouna-Renier, NK Katsiadaki, I Kawashima, Y Kloas, W Krueger, H Kumar, A Lagadic, L Leopold, A Levine, SL Maack, G Marty, S Meador, J Mihaich, E Odum, J Ortego, L Parrott, J Pickford, D Roberts, M Schaefers, C Schwarz, T Solomon, K Verslycke, T Weltje, L Wheeler, JR Williams, M Wolf, JC Yamazaki, K AF Matthiessen, Peter Ankley, Gerald T. Biever, Ronald C. Bjerregaard, Poul Borgert, Christopher Brugger, Kristin Blankinship, Amy Chambers, Janice Coady, Katherine K. Constantine, Lisa Dang, Zhichao Denslow, Nancy D. Dreier, David A. Dungey, Steve Gray, L. Earl Gross, Melanie Guiney, Patrick D. Hecker, Markus Holbech, Henrik Iguchi, Taisen Kadlec, Sarah Karouna-Renier, Natalie K. Katsiadaki, Ioanna Kawashima, Yukio Kloas, Werner Krueger, Henry Kumar, Anu Lagadic, Laurent Leopold, Annegaaike Levine, Steven L. Maack, Gerd Marty, Sue Meador, James Mihaich, Ellen Odum, Jenny Ortego, Lisa Parrott, Joanne Pickford, Daniel Roberts, Mike Schaefers, Christoph Schwarz, Tamar Solomon, Keith Verslycke, Tim Weltje, Lennart Wheeler, James R. Williams, Mike Wolf, Jeffrey C. Yamazaki, Kunihiko TI Recommended Approaches to the Scientific Evaluation of Ecotoxicological Hazards and Risks of Endocrine-Active Substances SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Article DE Endocrine disruptors; Ecotoxicological hazard assessment; Ecotoxicological risk assessment ID ADVERSE OUTCOME PATHWAYS; ZEBRAFISH DANIO-RERIO; DISRUPTING CHEMICALS; VITELLOGENIN PRODUCTION; FISH; RESPONSES; ETHYNYLESTRADIOL; THRESHOLDS; MECHANISMS; EXPOSURES AB A SETAC Pellston Workshop (R) Environmental Hazard and Risk Assessment Approaches for Endocrine-Active Substances (EHRA) was held in February 2016 in Pensacola, Florida, USA. The primary objective of the workshop was to provide advice, based on current scientific understanding, to regulators and policy makers; the aim being to make considered, informed decisions on whether to select an ecotoxicological hazard- or a risk-based approach for regulating a given endocrine-disrupting substance (EDS) under review. The workshop additionally considered recent developments in the identification of EDS. Case studies were undertaken on 6 endocrine-active substances (EAS-not necessarily proven EDS, but substances known to interact directly with the endocrine system) that are representative of a range of perturbations of the endocrine system and considered to be data rich in relevant information at multiple biological levels of organization for 1 or more ecologically relevant taxa. The substances selected were 17-ethinylestradiol, perchlorate, propiconazole, 17-trenbolone, tributyltin, and vinclozolin. The 6 case studies were not comprehensive safety evaluations but provided foundations for clarifying key issues and procedures that should be considered when assessing the ecotoxicological hazards and risks of EAS and EDS. The workshop also highlighted areas of scientific uncertainty, and made specific recommendations for research and methods-development to resolve some of the identified issues. The present paper provides broad guidance for scientists in regulatory authorities, industry, and academia on issues likely to arise during the ecotoxicological hazard and risk assessment of EAS and EDS. The primary conclusion of this paper, and of the SETAC Pellston Workshop on which it is based, is that if data on environmental exposure, effects on sensitive species and life-stages, delayed effects, and effects at low concentrations are robust, initiating environmental risk assessment of EDS is scientifically sound and sufficiently reliable and protective of the environment. In the absence of such data, assessment on the basis of hazard is scientifically justified until such time as relevant new information is available. Integr Environ Assess Manag 2017;13:267-279. (C) 2017 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of Society of Environmental Toxicology & Chemistry (SETAC) C1 [Ankley, Gerald T.] US Environm Protect Agcy, Duluth, MN USA. [Biever, Ronald C.] Smithers Viscient Labs, Wareham, MA USA. [Bjerregaard, Poul; Holbech, Henrik] Univ Southern Denmark, Dept Biol, Odense, Denmark. [Borgert, Christopher] Applied Pharmacol & Toxicol, Gainesville, FL USA. [Borgert, Christopher] Univ Florida, Coll Vet Med, CEHT, Dept Physiol Sci, Gainesville, FL USA. [Brugger, Kristin] Stine Haskell Res Ctr, DuPont Crop Protect, Newark, NJ USA. [Blankinship, Amy] United States Environm Protect Agcy, Off Pesticide Programs, Washington, DC USA. [Chambers, Janice] Mississippi State Univ, Coll Vet Med, Starkville, MS USA. [Coady, Katherine K.] Dow Chem Co USA, Toxicol & Environm Res & Consulting, Midland, MI USA. [Constantine, Lisa] 1Pfizer, Groton, CT USA. [Dang, Zhichao] RIVM, Bilthoven, Netherlands. [Denslow, Nancy D.] Univ Florida, Ctr Environm & Human Toxicol, Coll Vet Med, Dept Physiol Sci, Gainesville, FL USA. [Dungey, Steve] Environm Agcy, Wallingford, Oxon, England. [Gray, L. Earl] US Environm Agcy, Reprod Toxicol Branch, Res Triangle Pk, NC USA. [Gross, Melanie] WCA, Volunteer Way, Faringdon, England. [Guiney, Patrick D.] Univ Wisconsin, Mol & Environm Toxicol Ctr, Madison, WI USA. [Hecker, Markus] Univ Saskatchewan, Toxicol Ctr & Sch Environm & Sustainabil, Saskatoon, SK, Canada. [Iguchi, Taisen] Natl Inst Basic Biol, Okazaki, Aichi, Japan. [Kadlec, Sarah] Univ Minnesota, Integrated Biosciences Grad Program, Duluth, MN USA. [Karouna-Renier, Natalie K.] US Geol Survey Patuxent Wildlife Res Ctr, Beltsville, MD USA. [Katsiadaki, Ioanna; Schwarz, Tamar] Ctr Environm Fisheries & Aquaculture Sci, Weymouth, Dorset, England. [Kawashima, Yukio] Japan NUS Co, Shinjuku Ku, Tokyo, Japan. [Kloas, Werner] Leibniz Inst Freshwater Ecol & Inland Fisheries, Berlin, Germany. [Krueger, Henry] Wildlife Int, Easton, MD USA. [Kumar, Anu] CSIRO, Glen Osmond, SA, Australia. [Lagadic, Laurent] Bayer AG, Crop Sci Div, Environm Safety Ecotoxicol, Monheim, Germany. [Leopold, Annegaaike] Caldris Environm BV, Warnsveld, Netherlands. [Levine, Steven L.] Monsanto Co, Global Regulatory Sci, St Louis, MO USA. [Maack, Gerd] 2German Environm Agcy UBA, Dessau Rosslau, Germany. [Marty, Sue] Dow Chem Co USA, Midland, MI USA. [Meador, James] NOAA, Northwest Fisheries Sci Ctr, Ecotoxicol & Environm Fish Hlth Program, Seattle, WA USA. [Mihaich, Ellen] Environm & Regulatory Resources, Durham, NC USA. [Odum, Jenny] Regulatory Sci Associates, Binley Business Pk, Coventry, W Midlands, England. [Ortego, Lisa] Bayer CropSci, Res Triangle Pk, NC USA. [Parrott, Joanne] Water Sci & Technol Directorate, Environm & Climate Change Canada, Burlington, ON, Canada. [Pickford, Daniel] Jealotts Hill Int Res Ctr, Syngenta, Bracknell, Berks, England. [Schaefers, Christoph] Fraunhofer IME, Appl Ecol, Schmallenberg, Germany. [Solomon, Keith] Univ Guelph, Ctr Toxicol, Sch Environm Sci, Guelph, ON, Canada. [Verslycke, Tim] Gradient, Cambridge, MA USA. [Weltje, Lennart] BASF SE, Ecotoxicol, Rheinland Pfalz, Germany. [Wheeler, James R.] Dow AgroSci, Abingdon, Oxon, England. [Williams, Mike] CSIRO Land & Water, Waite Campus, Canberra, ACT, Australia. [Wolf, Jeffrey C.] Expt Pathol Labs, Sterling, VA USA. [Yamazaki, Kunihiko] Minist Environm, Dept Environm Hlth, Tokyo, Japan. RP No Org, Llanwrtyd Wells, England. EM peter@matthiessen.freeserve.co.uk RI Williams, Mike/I-1724-2013 FU WCA Environment Ltd. FX Wegratefully acknowledge the SETAC North America staff, in particular Greg Schiefer and Nikki Mayo, who provided support to the steering committee and workshop participants before, during, and after the workshop. We appreciate the funding support from industry, government, and consultancy groups that made the workshop possible. In addition, we thank the groups from academia, industry, and government who supported participants' travel. Finally, we would like to give special thanks to WCA Environment Ltd. for their support in the literature search in preparation of the case studies. NR 59 TC 4 Z9 4 U1 1 U2 1 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD MAR PY 2017 VL 13 IS 2 BP 267 EP 279 DI 10.1002/ieam.1885 PG 13 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA EM0MM UT WOS:000395012400005 PM 28127947 ER PT J AU Parrott, JL Bjerregaard, P Brugger, KE Gray, LE Iguchi, T Kadlec, SM Weltje, L Wheeler, JR AF Parrott, Joanne L. Bjerregaard, Poul Brugger, Kristin E. Gray, L. Earl, Jr. Iguchi, Taisen Kadlec, Sarah M. Weltje, Lennart Wheeler, James R. TI Uncertainties in Biological Responses that Influence Hazard and Risk Approaches to the Regulation of Endocrine Active Substances SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Article DE Delayed effects; Endocrine; Multigenerational effects; Nonmonotonic dose-response ID ZEBRAFISH DANIO-RERIO; MINNOW PIMEPHALES-PROMELAS; NONMONOTONIC DOSE-RESPONSES; IN-UTERO EXPOSURE; FATHEAD MINNOW; REPRODUCTIVE TOXICITY; DISRUPTING CHEMICALS; SEX-DIFFERENTIATION; ESTROGEN 17-ALPHA-ETHINYLESTRADIOL; SYNTHETIC ESTROGEN AB Endocrine-disrupting substances (EDS) may have certain biological effects including delayed effects, multigenerational effects, and may display nonmonotonic dose-response (NMDR) relationships that require careful consideration when determining environmental hazards. Endocrine disrupting substances can have specific and profound effects when exposure occurs during sensitive windows of the life cycle (development, reproduction). This creates the potential for delayed effects that manifest when exposure has ceased, possibly in a different life stage. This potential underscores the need for testing in appropriate (sensitive) life stages and full life cycle designs. Such tests are available in the Organisation for Economic Co-operation and Development (OECD) tool box and should be used to derive endpoints that can be considered protective of all life stages. Similarly, the potential for effects to be manifest in subsequent generations (multigenerational effects) has also been raised as a potential issue in the derivation of appropriate endpoints for EDS. However, multigenerational studies showing increasing sensitivity of successive generations are uncommon. Indeed this is reflected in the design of new higher tier tests to assess endocrine active substances (EAS) that move to extended one-generation designs and away from multi-generational studies. The occurrence of NMDRs is also considered a limiting factor for reliable risk assessment of EDS. Evidence to date indicates NMDRs are more prevalent in in vitro and mechanistic data, not often translating to adverse apical endpoints that would be used in risk assessment. A series of steps to evaluate NMDRs in the context of endocrine hazard and risk assessment procedures is presented. If careful consideration of delayed, multigenerational effects and NMDRs is made, it is feasible to assess environmental endocrine hazards and derive robust apical endpoints for risk assessment procedures ensuring a high level of environmental protection. Integr Environ Assess Manag 2017;13:293-301. (C) 2016 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of Society of Environmental Toxicology & Chemistry (SETAC) C1 [Parrott, Joanne L.] Environm & Climate Change Canada, Burlington, ON, Canada. [Bjerregaard, Poul] Univ Southern Denmark, Dept Biol, Odense, Denmark. [Brugger, Kristin E.] Stine Haskell Res Ctr, DuPont Crop Protect, Newark, NJ USA. [Gray, L. Earl, Jr.] US EPA, Reprod Toxicol Branch, Off Res & Dev, Res Triangle Pk, Durham, NC USA. [Iguchi, Taisen] Okazaki Inst Integrat Biosci, Natl Inst Basic Biol, Natl Inst Nat Sci, Dept Bioenvironm Res, Okazaki, Aichi, Japan. [Kadlec, Sarah M.] Univ Minnesota, Integrated Biosci Grad Program, Duluth, MN USA. [Weltje, Lennart] BASF SE, Crop Protect Ecotoxicol, Limburgerhof, Germany. [Wheeler, James R.] Dow AgroSci, Abingdon, Oxon, England. RP Parrott, JL (reprint author), Environm & Climate Change Canada, Burlington, ON, Canada. EM joanne.parrott@canada.ca NR 79 TC 5 Z9 5 U1 0 U2 0 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD MAR PY 2017 VL 13 IS 2 BP 293 EP 301 DI 10.1002/ieam.1866 PG 9 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA EM0MM UT WOS:000395012400007 PM 27862884 ER PT J AU Coady, KK Biever, RC Denslow, ND Gross, M Guiney, PD Holbech, H Karouna-Renier, NK Katsiadaki, I Krueger, H Levine, SL Maack, G Williams, M Wolf, JC Ankley, GT AF Coady, Katherine K. Biever, Ronald C. Denslow, Nancy D. Gross, Melanie Guiney, Patrick D. Holbech, Henrik Karouna-Renier, Natalie K. Katsiadaki, Ioanna Krueger, Hank Levine, Steven L. Maack, Gerd Williams, Mike Wolf, Jeffrey C. Ankley, Gerald T. TI Current Limitations and Recommendations to Improve Testing for the Environmental Assessment of Endocrine Active Substances SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Article DE Risk and hazard assessment; Endocrine disruption; High-throughput assays; Regulatory tests ID GROWTH PROMOTER 17-BETA-TRENBOLONE; ADVERSE OUTCOME PATHWAYS; TERM REPRODUCTION ASSAY; FATHEAD MINNOW; DISRUPTING CHEMICALS; FISH REPRODUCTION; ESTROGEN-RECEPTOR; MASS-SPECTROMETRY; SCREENING ASSAYS; ZEBRAFISH AB In the present study, existing regulatory frameworks and test systems for assessing potential endocrine active chemicals are described, and associated challenges are discussed, along with proposed approaches to address these challenges. Regulatory frameworks vary somewhat across geographies, but all basically evaluate whether a chemical possesses endocrine activity and whether this activity can result in adverse outcomes either to humans or to the environment. Current test systems include in silico, in vitro, and in vivo techniques focused on detecting potential endocrine activity, and in vivo tests that collect apical data to detect possible adverse effects. These test systems are currently designed to robustly assess endocrine activity and/or adverse effects in the estrogen, androgen, and thyroid hormone signaling pathways; however, there are some limitations of current test systems for evaluating endocrine hazard and risk. These limitations include a lack of certainty regarding: 1) adequately sensitive species and life stages; 2) mechanistic endpoints that are diagnostic for endocrine pathways of concern; and 3) the linkage between mechanistic responses and apical, adverse outcomes. Furthermore, some existing test methods are resource intensive with regard to time, cost, and use of animals. However, based on recent experiences, there are opportunities to improve approaches to and guidance for existing test methods and to reduce uncertainty. For example, in vitro high-throughput screening could be used to prioritize chemicals for testing and provide insights as to the most appropriate assays for characterizing hazard and risk. Other recommendations include adding endpoints for elucidating connections between mechanistic effects and adverse outcomes, identifying potentially sensitive taxa for which test methods currently do not exist, and addressing key endocrine pathways of possible concern in addition to those associated with estrogen, androgen, and thyroid signaling. Integr Environ Assess Manag 2017;13:302-316. (C) 2016 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of Society of Environmental Toxicology & Chemistry (SETAC) C1 [Coady, Katherine K.] Dow Chem Co USA, Toxicol & Environm Res & Consulting, Midland, MI 48674 USA. [Biever, Ronald C.] Smithers Viscient Labs, Wareham, MA USA. [Denslow, Nancy D.] Univ Florida, Dept Physiol Sci, Gainesville, FL USA. [Denslow, Nancy D.] Univ Florida, Ctr Environm & Human Toxicol, Gainesville, FL USA. [Gross, Melanie] Wca, Faringdon, England. [Guiney, Patrick D.] Univ Wisconsin, Mol & Environm Toxicol Ctr, Madison, WI USA. [Holbech, Henrik] Univ Southern Denmark, Dept Biol, Odense M, Denmark. [Karouna-Renier, Natalie K.] USGS Patuxent Wildlife Res Ctr, Beltsville, MD USA. [Katsiadaki, Ioanna] Ctr Environm Fisheries & Aquaculture Sci, Weymouth, Dorset, England. [Krueger, Hank] Wildlife Int, Div EAG Labs, Easton, MD USA. [Levine, Steven L.] Monsanto Co, Global Regulatory Sci, St Louis, MO USA. [Maack, Gerd] German Environm Agcy, Dessau Rosslau, Germany. [Williams, Mike] CSIRO Land & Water, Canberra, ACT, Australia. [Wolf, Jeffrey C.] Expt Pathol Labs, Sterling, VA USA. [Ankley, Gerald T.] US Environm Protect Agcy, Duluth, MN USA. RP Coady, KK (reprint author), Dow Chem Co USA, Toxicol & Environm Res & Consulting, Midland, MI 48674 USA. EM kcoady@dow.com RI Williams, Mike/I-1724-2013 NR 85 TC 5 Z9 5 U1 2 U2 2 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD MAR PY 2017 VL 13 IS 2 BP 302 EP 316 DI 10.1002/ieam.1862 PG 15 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA EM0MM UT WOS:000395012400008 PM 27791330 ER PT J AU Marty, MS Blankinship, A Chambers, J Constantine, L Kloas, W Kumar, A Lagadic, L Meador, J Pickford, D Schwarz, T Verslycke, T AF Marty, Mary S. Blankinship, Amy Chambers, Janice Constantine, Lisa Kloas, Werner Kumar, Anupama Lagadic, Laurent Meador, James Pickford, Daniel Schwarz, Tamar Verslycke, Tim TI Population-Relevant Endpoints in the Evaluation of Endocrine-Active Substances (EAS) for Ecotoxicological Hazard and Risk Assessment SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Article DE Population; Fish; Amphibian; Bird; Modeling ID ZEBRAFISH DANIO-RERIO; MINNOW PIMEPHALES-PROMELAS; NUCELLA-LAPILLUS; SYNTHETIC ESTROGEN; FATHEAD MINNOW; NASSARIUS-RETICULATUS; REPRODUCTIVE FUNCTION; PERCHLORATE EXPOSURE; ANTIFOULING PAINTS; TBT CONTAMINATION AB For ecotoxicological risk assessment, endocrine disruptors require the establishment of an endocrine mode of action (MoA) with a plausible link to a population-relevant adverse effect. Current ecotoxicity test methods incorporate mostly apical endpoints although some also include mechanistic endpoints, subcellular-through-organ level, which can help establish an endocrine MoA. However, the link between these endpoints and adverse population-level effects is often unclear. The case studies of endocrine-active substances (EAS) (tributyltin, ethinylestradiol, perchlorate, trenbolone, propiconazole, and vinclozolin) evaluated from the Society of Environmental Toxicology and Chemistry (SETAC) Pellston Workshop (R) Ecotoxicological Hazard and Risk Assessment Approaches for Endocrine-Active Substances (EHRA)" were used to evaluate the population relevance of toxicity endpoints in various taxa according to regulatory endocrine-disruptor frameworks such as the Organisation for Economic Co-operation and Development (OECD) Conceptual Framework for Testing and Assessment of Endocrine Disruptors. A wide variety of potentially endocrine-relevant endpoints were identified for mollusks, fish, amphibians, birds, and mammals, although the strength of the relationship between test endpoints and population-level effects was often uncertain. Furthermore, testing alone is insufficient for assessing potential adaptation and recovery processes in exposed populations. For this purpose, models that link effects observed in laboratory tests to the dynamics of wildlife populations appear to be necessary, and their development requires reliable and robust data. As our understanding of endocrine perturbations and key event relationships improves, adverse population-level effects will be more easily and accurately predicted. Integr Environ Assess Manag 2017;13:317-330. (C) 2017 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of Society of Environmental Toxicology & Chemistry (SETAC) C1 [Marty, Mary S.] Dow Chem Co USA, Midland, MI 48674 USA. [Blankinship, Amy] US Environm Protect Agcy, Washington, DC USA. [Chambers, Janice] Mississippi State Univ, Mississippi State, MS USA. [Constantine, Lisa] Pfizer, New York, NY USA. [Kloas, Werner] Leibniz Inst Freshwater Ecol & Inland Fisheries, Berlin, Germany. [Kumar, Anupama] CSIRO, Adelaide, SA, Australia. [Lagadic, Laurent] Bayer AG CropSci Div, Monheim, Germany. [Meador, James] Northwest Fisheries Sci Ctr, NOAA Fisheries, Seattle, WA USA. [Pickford, Daniel] Syngenta UK, Cambridge, England. [Schwarz, Tamar] Ctr Environm Fisheries & Aquaculture Sci, Weymouth, Dorset, England. [Verslycke, Tim] Gradient, Cambridge, MA USA. RP Marty, MS (reprint author), Dow Chem Co USA, Midland, MI 48674 USA. EM msmarty@dow.com NR 87 TC 4 Z9 4 U1 0 U2 0 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD MAR PY 2017 VL 13 IS 2 BP 317 EP 330 DI 10.1002/ieam.1887 PG 14 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA EM0MM UT WOS:000395012400009 PM 28052490 ER PT J AU Syberg, K Backhaus, T Banta, G Bruce, P Gustavsson, M Munns, WR Ramo, R Selck, H Gunnarsson, JS AF Syberg, Kristian Backhaus, Thomas Banta, Gary Bruce, Peter Gustavsson, Mikael Munns, Wayne R., Jr. Ramo, Robert Selck, Henriette Gunnarsson, Jonas S. TI Toward a Conceptual Approach for Assessing Risks from Chemical Mixtures and Other Stressors to Coastal Ecosystem Services SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Article DE Environmental risk assessment; Multiple stressors; Coastal areas; Chemical contamination; Ecosystem services ID DECISION-MAKING; ECOLOGICAL RISK; COSTA-RICA; TOXICITY; FRAMEWORK; BANANA AB Growth of human populations and increased human activity, particularly in coastal areas, increase pressure on coastal ecosystems and the ecosystem services (ES) they provide. As a means toward being able to assess the impact of multiple stressors on ES, in the present study we propose an 8-step conceptual approach for assessing effects of chemical mixtures and other stressors on ES in coastal areas: step A, identify the relevant problems and policy aims; step B, identify temporal and spatial boundaries; step C, identify relevant ES; step D, identify relevant stressors (e.g., chemicals); step E, translate impacts into ES units; step F, assess cumulative risk in ES units; step G, rank stressors based on their contribution to adverse effects on ES; and step H, implement regulation and management as appropriate and necessary. Two illustrative case studies (Swedish coastal waters and a coastal lagoon in Costa Rica) are provided; one focuses on chemicals that affect human food supply and the other addresses pesticide runoff and trade-offs among ES. The 2 cases are used to highlight challenges of such risk assessments, including use of standardized versus ES-relevant test species, data completeness, and trade-offs among ES. Lessons learned from the 2 case studies are discussed in relation to environmental risk assessment and management of chemical mixtures. Integr Environ Assess Manag 2017;13:376-386. (C) 2016 SETAC C1 [Syberg, Kristian; Banta, Gary; Selck, Henriette] Roskilde Univ, Dept Sci & Environm, Roskilde, Denmark. [Backhaus, Thomas; Gustavsson, Mikael] Univ Gothenburg, Dept Biol & Environm Sci, Gothenburg, Sweden. [Bruce, Peter; Ramo, Robert; Gunnarsson, Jonas S.] Stockholm Univ, Dept Ecol Environm & Plant Sci, Stockholm, Sweden. [Munns, Wayne R., Jr.] US Environm Protect Agcy, Atlantic Ecol Div, Narragansett, RI USA. RP Syberg, K (reprint author), Roskilde Univ, Dept Sci & Environm, Roskilde, Denmark. EM ksyberg@ruc.dk FU Roskilde University; Environmental Risk Research Initiative; Villum Foundation [VKR022070]; Swedish Research Council FORMAS [NICE [2011-1733], ChemToFish [2012-2091]] FX We thank Tina Ramskov for gathering the literature for the persistent, bioaccumulative, and toxic/vPvB substance review. Wethank editors Peter Chapman and Allen Burton for constructive feedback and 2 anonymous peer reviewers for their constructive feedback. We also wish to thank Roskilde University and their Environmental Risk Research Initiative for organizing, hosting, and funding the SUNRISE workshop, where this work was presented. The contributions of KS and HS were funded by the Villum Foundation (project VKR022070). The contributions of TB and MG were supported by the Swedish Research Council FORMAS (projects NICE [2011-1733] and ChemToFish [2012-2091]). NR 34 TC 0 Z9 0 U1 2 U2 2 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD MAR PY 2017 VL 13 IS 2 BP 376 EP 386 DI 10.1002/ieam.1849 PG 11 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA EM0MM UT WOS:000395012400015 PM 27662428 ER PT J AU Suter, G AF Suter, Glenn TI MARINE ECOTOXICOLOGY: CURRENT KNOWLEDGE AND FUTURE ISSUES SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Book Review C1 [Suter, Glenn] US EPA, 26 Martin Luther King Dr,MC A110, Cincinnati, OH 45268 USA. RP Suter, G (reprint author), US EPA, 26 Martin Luther King Dr,MC A110, Cincinnati, OH 45268 USA. EM suter.glenn@epamail.epa.gov NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD MAR PY 2017 VL 13 IS 2 BP 453 EP 453 PG 1 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA EM0MM UT WOS:000395012400027 ER PT J AU Hobbs, WO Edlund, MB Umbanhowar, CE Camill, P Lynch, JA Geiss, C Stefanova, V AF Hobbs, William O. Edlund, Mark B. Umbanhowar, Charles E., Jr. Camill, Philip Lynch, Jason A. Geiss, Christoph Stefanova, Vania TI Holocene evolution of lakes in the forest-tundra biome of northern Manitoba, Canada SO QUATERNARY SCIENCE REVIEWS LA English DT Article DE Subarctic; Paleolimnology; Diatoms; Lake ontogeny; Holocene Thermal Maximum; Northern Manitoba; Little Ice Age; Anthropocene ID HUDSON-BAY LOWLANDS; RECENT ENVIRONMENTAL-CHANGES; CLIMATE-CHANGE; PALEOLIMNOLOGICAL EVIDENCE; ALPINE LAKES; ARCTIC LAKES; COLD EVENT; DIATOM; SEDIMENTS; POLLEN AB The late-Quaternary paleoenvironmental history of the western Hudson Bay region of Subarctic Canada is poorly constrained. Here, we present a regional overview of the post-glacial history of eight lakes which span the forest-tundra biome in northern Manitoba. We show that during the penultimate drainage phase of Lake Agassiz the lake water had an estimated pH of -6.0, with abundant quillwort (Isoetes spp.) along the lakeshore and littoral zone and some floating green algae (Botryococcus spp. and Pediastrum sp.). Based on multiple sediment proxies, modern lake ontogeny in the region commenced at -7500 cal yrs BP. Pioneering diatom communities were shaped by the turbid, higher alkalinity lake waters which were influenced by base cation weathering of the surrounding till following Lake Agassiz drainage. By -7000 cal yrs BP, soil development and Picea spp. establish and the lakes began a slow trajectory of acidification over the remaining Holocene epoch. The natural acidification of the lakes in this region is slow, on the order of several millennia for one pH unit. Each of the study lakes exhibit relatively stable aquatic communities during the Holocene Thermal Maximum, suggesting this period is a poor analogue for modern climatic changes. During the Neoglacial, the beginning of the post-Little Ice Age period represents the most significant climatic event to impact the lakes of N. Manitoba. In the context of regional lake histories, the rate of diatom floristic change in the last 200-300 years is unprecedented, with the exception of post-glacial lake ontogeny in some of the lakes. For nearly the entire history of the lakes in this region, there is a strong linkage between landscape development and the aquatic ecosystems; however this relationship appears to become decoupled or less strong in the post-LIA period. Significant 20th century changes in the aquatic ecosystem cannot be explained wholly by changes in the terrestrial ecosystem, suggesting that future changes to the lakes of N. Manitoba will be strongly influenced by direct climatic effects to the lakes. (C) 2017 Elsevier Ltd. All rights reserved. C1 [Hobbs, William O.; Edlund, Mark B.] Sci Museum Minnesota, St Croix Watershed Res Stn, 16910 152nd St North, Marine St Croix, MN 55047 USA. [Umbanhowar, Charles E., Jr.] St Olaf Coll, Dept Biol, Northfield, MN 55057 USA. [Camill, Philip] Bowdoin Coll, Environm Studies Program, Brunswick, ME 04011 USA. [Camill, Philip] Bowdoin Coll, Earth & Oceanog Sci Dept, Brunswick, ME 04011 USA. [Lynch, Jason A.] US EPA, Off Air & Radiat, 1200 Penn Ave NW, Washington, DC 20460 USA. [Geiss, Christoph] Trinity Coll, Dept Phys, Hartford, CT 06106 USA. [Geiss, Christoph] Trinity Coll, Environm Sci Program, Hartford, CT 06106 USA. [Stefanova, Vania] Univ Minnesota, Dept Earth Sci, 310 Pillsbury Dr SE, Minneapolis, MN 55455 USA. [Hobbs, William O.] Washington State Dept Ecol, POB 14700, Olympia, WA 98504 USA. RP Hobbs, WO (reprint author), Sci Museum Minnesota, St Croix Watershed Res Stn, 16910 152nd St North, Marine St Croix, MN 55047 USA.; Hobbs, WO (reprint author), Washington State Dept Ecol, POB 14700, Olympia, WA 98504 USA. EM whobbs2@gmail.com FU National Science Foundation [DEB-0743364, DEB-0904050, DEB-0092704, DBI-0520803] FX Tom Brown at the Center for Accelerator Mass Spectrometry, Lawrence Livermore National Laboratory provided the radiocarbon dating of macrofossils and Dan Engstrom at St. Croix Watershed Research Station dated and provided interpretation of recent sediments using 210Pb methods. Thank you also to pilots Jon Kovac, Jason Essaunce, and Mark Leyden and the staff at The Lodge at Little Duck for assistance in the field. Undergraduates Kendra Passow, Pat Henneghan and Mark Krueger also provide much able help. This study was supported by National Science Foundation grants DEB-0743364. DEB-0904050, DEB-0092704, and DBI-0520803. Initial core processing was performed at the Limnological Research Center/LacCore (University of Minnesota). NR 116 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0277-3791 J9 QUATERNARY SCI REV JI Quat. Sci. Rev. PD MAR 1 PY 2017 VL 159 BP 116 EP 138 DI 10.1016/j.quascirev.2017.01.014 PG 23 WC Geography, Physical; Geosciences, Multidisciplinary SC Physical Geography; Geology GA EM9CR UT WOS:000395609300009 ER PT J AU Lefohn, AS Malley, CS Simon, H Wells, B Xu, XB Zhang, L Wang, T AF Lefohn, Allen S. Malley, Christopher S. Simon, Heather Wells, Benjamin Xu, Xiaobin Zhang, Li Wang, Tao TI Responses of human health and vegetation exposure metrics to changes in ozone concentration distributions in the European Union, United States, and China SO ATMOSPHERIC ENVIRONMENT LA English DT Article DE Binning concentrations; Exposure metrics; Ozone distributions; NOx scavenging; Shifting concentrations; Trends ID WESTERN NORTH-AMERICA; LONG-RANGE TRANSPORT; GROUND-LEVEL OZONE; SURFACE OZONE; AIR-QUALITY; CLIMATE-CHANGE; TROPOSPHERIC OZONE; NITROGEN-OXIDES; URBAN AREAS; EMISSION INVENTORY AB The impacts of surface ozone (O-3) on human health and vegetation have prompted O-3 precursor emission reductions in the European Union (EU) and United States (US). In contrast, until recently, emissions have increased in East Asia and most strongly in China. As emissions change, the distribution of hourly O-3 concentrations also changes, as do the values of exposure metrics. The distribution changes can result in the exposure metric trend patterns changing in a similar direction as trends in emissions (e.g., metrics increase as emissions increase) or, in some cases, in opposite directions. This study, using data from 481 sites (276 in the EU, 196 in the US, and 9 in China), investigates the response of 14 human health and vegetation O-3 exposure metrics to changes in hourly O-3 concentration distributions over time. At a majority of EU and US sites, there was a reduction in the frequency of both relatively high and low hourly average O-3 concentrations. In contrast, for some sites in mainland China and Hong Kong, the middle of the distribution shifted upwards but the low end did not change and for other sites, the entire distribution shifted upwards. The responses of the 14 metrics to these changes at the EU, US, and Chinese sites were varied, and dependent on (1) the extent to which the metric was determined by relatively high, moderate, and low concentrations and (2) the relative magnitude of the shifts occurring within the O-3 concentration distribution. For example, the majority of the EU and US sites experienced decreasing trends in the magnitude of those metrics associated with higher concentrations. For the sites in China, all of the metrics either increased or had no trends. In contrast, there were a greater number of sites that had no trend for those metrics determined by a combination of moderate and high O-3 concentrations. A result of our analyses is that trends in mean or median concentrations did not appear to be well associated with some exposure metrics applicable for assessing human health or vegetation effects. The identification of shifting patterns in the O-3 distribution and the resulting changes in O-3 exposure metrics across regions with large emission increases and decreases is an important step in examining the linkage between emissions and exposure metric trends. The results provide insight into the utility of using specific exposure metrics for assessing emission control strategies. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Lefohn, Allen S.] ASL & Associates, Helena, MT 59601 USA. [Malley, Christopher S.] Univ York, Dept Environm, Stockholm Environm Inst, York YO10 5DD, N Yorkshire, England. [Simon, Heather; Wells, Benjamin] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA. [Xu, Xiaobin] Chinese Acad Meteorol Sci, Inst Atmospher Composit, Key Lab Atmospher Chem, Beijing 100081, Peoples R China. [Zhang, Li; Wang, Tao] Hong Kong Polytech Univ, Dept Civil & Environm Engn, Hong Kong, Hong Kong, Peoples R China. RP Lefohn, AS (reprint author), ASL & Associates, 302 North Last Chance Gulch, Helena, MT 59601 USA. EM alefohn@asl-associates.com; malley.chris@gmail.com; simon.heather@epa.gov; Wells.Benjamin@epamail.epa.gov; xuxb@camscma.cn; alex.zhang@connect.polyu.hk; tao.wang@polyu.edu.hk FU National Science Foundation of China [41330422]; Hong Kong Research Grants Council [PolyU 153042/15E]; Hong Kong Polytechnic University [G-S023] FX We wish to acknowledge the assistance of Mr. Nick Mangus, US EPA's Office of Air Quality Policy and Standards, for providing technical insight concerning O3 monitoring sites in the US. One of the authors (ASL) wishes to acknowledge his company, A.S.L. & Associates, for providing the necessary resources that allowed him to participate in the study. The author (XX) from the Chinese Academy of Meteorological Sciences acknowledges the support from the National Science Foundation of China (No. 41330422). The O3 observations at Mt. Waliguan, Shangdianzi, and Longfengshan are supported by the China Meteorological Administration. The Hong Kong authors (TW and LZ) acknowledge the support from the Hong Kong Research Grants Council (PolyU 153042/15E). The O3 observations at Hok Tsui are supported by The Hong Kong Polytechnic University (Project No. G-S023). Two of the authors (HS and BW) wish to note that although this work has been reviewed and approved for publication by the US Environmental Protection Agency (EPA), it does not reflect the views and policies of the agency. NR 119 TC 0 Z9 0 U1 1 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 EI 1873-2844 J9 ATMOS ENVIRON JI Atmos. Environ. PD MAR PY 2017 VL 152 BP 123 EP 145 DI 10.1016/j.atmosenv.2016.12.025 PG 23 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA EL1RZ UT WOS:000394400000012 ER PT J AU Silvestri, EE Yund, C Taft, S Bowling, CY Chappie, D Garrahan, K Brady-Roberts, E Stone, H Nichols, TL AF Silvestri, Erin E. Yund, Cynthia Taft, Sarah Bowling, Charlena Yoder Chappie, Daniel Garrahan, Kevin Brady-Roberts, Eletha Stone, Harry Nichols, Tonya L. TI Considerations estimating microbial environmental data concentrations collected from a field setting SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY LA English DT Review DE analytical methods; environmental monitoring; inhalation exposure ID BACILLUS-ANTHRACIS SPORES; RAPID-DETECTION METHODS; NONPOROUS SURFACES; SAMPLE COLLECTION; RECOVERY EFFICIENCY; SWAB PROTOCOL; COUNT DATA; QUANTITATIVE PCR; RISK; VALIDATION AB In the event of an indoor release of an environmentally persistent microbial pathogen such as Bacillus anthracis, the potential for human exposure will be considered when remedial decisions are made. Microbial site characterization and clearance sampling data collected in the field might be used to estimate exposure. However, there are many challenges associated with estimating environmental concentrations of B. anthracis or other spore-forming organisms after such an event before being able to estimate exposure. These challenges include: (1) collecting environmental field samples that are adequate for the intended purpose, (2) conducting laboratory analyses and selecting the reporting format needed for the laboratory data, and (3) analyzing and interpreting the data using appropriate statistical techniques. This paper summarizes some key challenges faced in collecting, analyzing, and interpreting microbial field data from a contaminated site. Although the paper was written with considerations for B. anthracis contamination, it may also be applicable to other bacterial agents. It explores the implications and limitations of using field data for determining environmental concentrations both before and after decontamination. Several findings were of interest. First, to date, the only validated surface/sampling device combinations are swabs and sponge-sticks on stainless steel surfaces, thus limiting availability of quantitative analytical results which could be used for statistical analysis. Second, agreement needs to be reached with the analytical laboratory on the definition of the countable range and on reporting of data below the limit of quantitation. Finally, the distribution of the microbial field data and statistical methods needed for a particular data set could vary depending on these data that were collected, and guidance is needed on appropriate statistical software for handling microbial data. Further, research is needed to develop better methods to estimate human exposure from pathogens using environmental data collected from a field setting. C1 [Silvestri, Erin E.; Yund, Cynthia; Taft, Sarah; Bowling, Charlena Yoder; Brady-Roberts, Eletha] US EPA, Natl Homeland Secur Res Ctr, Threat Consequence Assessment Div, Cincinnati, OH 45268 USA. [Chappie, Daniel; Garrahan, Kevin; Stone, Harry] Battelle Mem Inst, 505 King Ave, Columbus, OH 43201 USA. [Nichols, Tonya L.] US EPA, Natl Homeland Secur Res Ctr, Threat Consequence Assessment Div, Washington, DC 20460 USA. RP Silvestri, EE (reprint author), US EPA, Natl Homeland Secur Res Ctr, 26 West Martin Luther King Dr,MS NG16, Cincinnati, OH 45268 USA. EM Silvestri.Erin@epa.gov FU U. S. EPA, through its Office of Research and Development under the Battelle/ Chemical, Biological, Radiological; Nuclear Defense Information and Analysis Center [SP0700-00-D-3180] FX The U. S. EPA, through its Office of Research and Development, funded and managed this effort under the Battelle/ Chemical, Biological, Radiological, and Nuclear Defense Information and Analysis Center Contract No. SP0700-00- D-3180, Delivery Order 0679, Technical Area Task 886. Input was also received from the CDC. The contents do not necessarily reflect the views of the U. S. government. Reference herein to any specific commercial product, service by trade name, trademark, manufacturer, and so on. does not constitute or imply its endorsement, recommendation, or favoring by the U. S. government. The following individuals are recognized for their contributions: Hiba Ernst (EPA), Deborah McKean ( EPA), Wendy O'Brien (EPA), Angela Weber (CDC), Stephen Morse (CDC), Laura Rose (CDC), Sean Shadomy (CDC), and Marti Sinclair (Alion Science and Technology). NR 124 TC 0 Z9 0 U1 2 U2 2 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1559-0631 EI 1559-064X J9 J EXPO SCI ENV EPID JI J. Expo. Sci. Environ. Epidemiol. PD MAR-APR PY 2017 VL 27 IS 2 BP 141 EP 151 DI 10.1038/jes.2016.3 PG 11 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA EL2NM UT WOS:000394456500002 PM 26883476 ER PT J AU Baxter, LK Stallings, C Smith, L Burke, J AF Baxter, Lisa K. Stallings, Casson Smith, Luther Burke, Janet TI Probabilistic estimation of residential air exchange rates for population-based human exposure modeling SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY LA English DT Article DE air exchange rates; air pollution; exposure error; exposure modeling; infiltration; model evaluation ID FINE PARTICULATE MATTER; POLLUTION EXPOSURE; NORTH-CAROLINA; PM2.5; INFILTRATION; DISTRIBUTIONS; OUTDOOR; INDOOR; PHILADELPHIA; VARIABILITY AB Residential air exchange rates (AERs) are a key determinant in the infiltration of ambient air pollution indoors. Population-based human exposure models using probabilistic approaches to estimate personal exposure to air pollutants have relied on input distributions from AER measurements. An algorithm for probabilistically estimating AER was developed based on the Lawrence Berkley National Laboratory Infiltration model utilizing housing characteristics and meteorological data with adjustment for window opening behavior. The algorithm was evaluated by comparing modeled and measured AERs in four US cities (Los Angeles, CA; Detroit, MI; Elizabeth, NJ; and Houston, TX) inputting study-specific data. The impact on the modeled AER of using publically available housing data representative of the region for each city was also assessed. Finally, modeled AER based on region-specific inputs was compared with those estimated using literature-based distributions. While modeled AERs were similar in magnitude to the measured AER they were consistently lower for all cities except Houston. AERs estimated using region-specific inputs were lower than those using study-specific inputs due to differences in window opening probabilities. The algorithm produced more spatially and temporally variable AERs compared with literature-based distributions reflecting within-and between-city differences, helping reduce error in estimates of air pollutant exposure. C1 [Baxter, Lisa K.] US EPA, Natl Hlth & Environm Effects Res Lab, 109 TW Alexander Dr,Mail Code E205-02, Res Triangle Pk, NC 27709 USA. [Stallings, Casson; Smith, Luther] Alion Sci & Technol Inc, Durham, NC USA. [Burke, Janet] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. RP Baxter, LK (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, 109 TW Alexander Dr,Mail Code E205-02, Res Triangle Pk, NC 27709 USA. EM Baxter.lisa@epa.gov FU United States Environmental Protection Agency through its Office of Research and Development [EPD10070] FX We would also like to thank Kathie Dionisio of the US EPA's National Exposure Laboratory for her scientific guidance on this manuscript. The United States Environmental Protection Agency through its Office of Research and Development partially funded and collaborated in the research described here under contract number EPD10070 to Alion Science and Technology Inc. It has been subjected to Agency review and approved for publication. NR 25 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1559-0631 EI 1559-064X J9 J EXPO SCI ENV EPID JI J. Expo. Sci. Environ. Epidemiol. PD MAR-APR PY 2017 VL 27 IS 2 BP 227 EP 234 DI 10.1038/jes.2016.49 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA EL2NM UT WOS:000394456500012 PM 27553990 ER PT J AU Glassmeyer, ST Furlong, ET Kolpin, DW Batt, AL Benson, R Boone, JS Conerly, O Donohue, MJ King, DN Kostich, MS Mash, HE Pfaller, SL Schenck, KM Simmons, JE Varughese, EA Vesper, SJ Villegas, EN Wilson, VS AF Glassmeyer, Susan T. Furlong, Edward T. Kolpin, Dana W. Batt, Angela L. Benson, Robert Boone, J. Scott Conerly, Octavia Donohue, Maura J. King, Dawn N. Kostich, Mitchell S. Mash, Heath E. Pfaller, Stacy L. Schenck, Kathleen M. Simmons, Jane Ellen Varughese, Eunice A. Vesper, Stephen J. Villegas, Eric N. Wilson, Vickie S. TI Nationwide reconnaissance of contaminants of emerging concern in source and treated drinking waters of the United States SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Pharmaceuticals; Microorganisms; Contaminants of emerging concern; Drinking water; Source water ID PUBLIC-HEALTH SIGNIFICANCE; SOLID-PHASE EXTRACTION; ORGANIC-COMPOUNDS; WASTE-WATER; PHARMACEUTICAL COMPOUNDS; MASS-SPECTROMETRY; QUANTITATIVE PCR; TREATMENT PLANTS; SURFACE-WATER; ENVIRONMENT AB When chemical or microbial contaminants are assessed for potential effect or possible regulation in ambient and drinking waters, a critical first step is determining if the contaminants occur and if they are at concentrations that may cause human or ecological health concerns. To this end, source and treated drinking water samples from 29 drinking water treatment plants (DWTPs) were analyzed as part of a two-phase study to determine whether chemical and microbial constituents, many of which are considered contaminants of emerging concern, were detectable in the waters. Of the 84 chemicals monitored in the 9 Phase I DWTPs, 27 were detected at least once in the source water, and 21 were detected at least once in treated drinking water. In Phase II, which was a broader and more comprehensive assessment, 247 chemical and microbial analytes were measured in 25 DVVTPs, with 148 detected at least once in the source water, and 121 detected at least once in the treated drinking water. The frequency of detection was often related to the analyte's contaminant class, as pharmaceuticals and anthropogenic waste indicators tended to be infrequently detected and more easily removed during treatment, while per and polyfluoroalkyl substances and inorganic constituents were both more frequently detected and, overall, more resistant to treatment. The data collected as part of this project will be used to help inform evaluation of unregulated contaminants in surface water, groundwater, and drinking water. Published by Elsevier B.V. C1 [Glassmeyer, Susan T.; Batt, Angela L.; Donohue, Maura J.; King, Dawn N.; Kostich, Mitchell S.; Mash, Heath E.; Pfaller, Stacy L.; Schenck, Kathleen M.; Varughese, Eunice A.; Vesper, Stephen J.; Villegas, Eric N.] US EPA, Off Res & Dev, Natl Exposure Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. [Furlong, Edward T.] USGS, Natl Water Qual Lab, Denver Fed Ctr, Bldg 95, Denver, CO 80225 USA. [Kolpin, Dana W.] USGS, 400 S Clinton St,Rm 269 Fed Bldg, Iowa City, IA 52240 USA. [Benson, Robert] US EPA, Reg 8,1595 Wynkoop St,Mail Code 8P-W, Denver, CO 80202 USA. [Boone, J. Scott] US EPA, Off Chem Safety & Pollut Prevent, Stennis Space Ctr, MS USA. [Conerly, Octavia] US EPA, Off Water Off Sci & Technol, William Jefferson Clinton Bldg,1200 Penn Av, Washington, DC 20460 USA. [Simmons, Jane Ellen; Wilson, Vickie S.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Boone, J. Scott] Mississippi State Chem Lab, 1145 Hand Lab,310 Presidents Cr,POB CR, Mississippi State, MS 39762 USA. RP Glassmeyer, ST (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM glassmeyer.susan@epa.gov; efurlong@usgs.gov; dwkolpin@usgs.gov; batt.angela@epa.gov; benson.bob@epa.gov; sboone@mscl.msstate.edu; conerly.octavia@epa.gov; donohue.maura@epa.gov; king.dawn@epa.gov; kostich.mitchell@epa.gov; mash.heath@epa.gov; pfaller.stacy@epa.gov; Schenck.kathleen@epa.gov; simmonsjane@epa.gov; varughese.eunice@epa.gov; vesper.stephen@epa.gov; villegas.eric@epa.gov; wilson.vickie@epa.gov FU U.S. Environmental Protection Agency through Interagency Agreement [DW14922330]; USGS Toxic Substances Hydrology Program; USEPA's Office of Research and Development, Office of Water, Office of Chemical Safety and Pollution Prevention; Information Collection Rule [2346.01, 2080-0078] FX The research described in this article has been funded in part by the U.S. Environmental Protection Agency through Interagency Agreement DW14922330 to the U.S. Geological Survey, and through programmatic support of the USGS Toxic Substances Hydrology Program and the USEPA's Office of Research and Development, Office of Water, Office of Chemical Safety and Pollution Prevention, and Region 8. Information Collection Rule approval for the Phase II Questionnaire was granted under EPA ICR No. 2346.01, OMB Control No. 2080-0078. This document has been reviewed in accordance with USEPA and USGS policy and approved for publication. Approval does not signify that the contents reflect the views of the USEPA and mention of trade names or commercial products does not constitute endorsement or recommendation for use by USEPA. Any use of trades firm, or product names is for descriptive purposes only and does not imply endorsement by the USEPA, the USGS, or the U.S. Government. The authors would like to thank all participating drinking water treatment plants for their involvement in the project and for their assistance in collecting the samples. The authors would also like to thank the following personnel for sample and data analysis assistance: Steve Werner, Steve Zaugg, Mary Noriega, Richard Miltner, Bing Guan, Craig Vigo, Tripp Boone, Christian Byrne, Joseph Ferrario, Nicola Evans, Justin Conley, Laura Rosenblum, Michael Ware, Megan Vogel, Robert Flick, William Sander, Nichole Brinkman, Emily Anneken, and Scott Keely. NR 64 TC 0 Z9 0 U1 3 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD MAR 1 PY 2017 VL 581 BP 909 EP 922 DI 10.1016/j.scitotenV2016.12.004 PG 14 WC Environmental Sciences SC Environmental Sciences & Ecology GA EL5AZ UT WOS:000394635300090 PM 28024752 ER PT J AU Liu, H Wei, H Zuo, T Li, ZX Yang, YJ AF Liu, Hao Wei, Heng Zuo, Ting Li, Zhixia Yang, Y. Jeffrey TI Fine-tuning ADAS algorithm parameters for optimizing traffic safety and mobility in connected vehicle environment SO TRANSPORTATION RESEARCH PART C-EMERGING TECHNOLOGIES LA English DT Article DE Advanced Driver Assistance System (ADAS); Driver behavior modeling; Microscopic traffic flow modeling; Traffic safety and mobility optimization ID COLLISION WARNING SYSTEM; DRIVER ASSISTANCE SYSTEMS; SIMULATION; BEHAVIOR; PERFORMANCE; TRUST AB Under the Connected Vehicle environment where vehicles and road-side infrastructure can communicate wirelessly, the Advanced Driver Assistance Systems (ADAS) can be adopted as an actuator for achieving traffic safety and mobility optimization at highway facilities. In this regard, the traffic management centers need to identify the optimal ADAS algorithm parameter set that leads to the optimization of the traffic safety and mobility performance, and broadcast the optimal parameter set wirelessly to individual ADAS-equipped vehicles. Once the ADAS-equipped drivers implement the optimal parameter set, they become active agents that work cooperatively to prevent traffic conflicts, and suppress the development of traffic oscillations into heavy traffic jams. Measuring systematic effectiveness of this traffic management requires am analytic capability to capture the quantified impact of the ADAS on individual drivers' behaviors and the aggregated traffic safety and mobility improvement due to such an impact. To this end, this research proposes a synthetic methodology that incorporates the ADAS-affected driving behavior modeling and stateof-the-art microscopic traffic flow modeling into a virtually simulated environment. Building on such an environment, the optimal ADAS algorithm parameter set is identified through a multi-objective optimization approach that uses the Genetic Algorithm. The developed methodology is tested at a freeway facility under low, medium and high ADAS market penetration rate scenarios. The case study reveals that fine-tuning the ADAS algorithm parameter can significantly improve the throughput and reduce the traffic delay and conflicts at the study site in the medium and high penetration scenarios. In these scenarios, the ADAS algorithm parameter optimization is necessary. Otherwise the ADAS will intensify the behavior heterogeneity among drivers, resulting in little traffic safety improvement and negative mobility impact. In the high penetration rate scenario, the identified optimal ADAS algorithm parameter set can be used to support different control objectives (e.g., safety improvement has priority vs. mobility improvement has priority). (C) 2017 Elsevier Ltd. All rights reserved. C1 [Liu, Hao; Wei, Heng; Zuo, Ting] Univ Cincinnati, Coll Engn & Appl Sci, Dept Civil & Architectural Engn & Construct Manag, 792 Rhodes Hall, Cincinnati, OH 45221 USA. [Li, Zhixia] Univ Louisville, Dept Civil & Environm Engn, WS Speed Hall 111, Louisville, KY 40292 USA. [Yang, Y. Jeffrey] US EPA, Water Supply & Water ReOurces Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Wei, H (reprint author), Univ Cincinnati, Coll Engn & Appl Sci, Dept Civil & Architectural Engn & Construct Manag, 792 Rhodes Hall, Cincinnati, OH 45221 USA. EM heng.wei@uc.edu FU U.S. Environmental Protection Agency via its Office of Research and Development FX The authors appreciate the support of the U.S. Environmental Protection Agency via funded research through its Office of Research and Development. It has been subjected to the Agency's administrative review and has been approved for external publication. Any opinions expressed in this paper are those of the author(s) and do not necessarily reflect the views of the Agency; therefore, no official endorsement should be inferred. Any mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 44 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0968-090X J9 TRANSPORT RES C-EMER JI Transp. Res. Pt. C-Emerg. Technol. PD MAR PY 2017 VL 76 BP 132 EP 149 DI 10.1016/j.trc.2017.01.003 PG 18 WC Transportation Science & Technology SC Transportation GA EL1QQ UT WOS:000394396500008 ER PT J AU Deziel, NC Freeman, LEB Graubard, BI Jones, RR Hoppin, JA Thomas, K Hines, CJ Blair, A Sandler, DP Chen, HL Lubin, JH Andreotti, G Alavanja, MCR Friesen, MC AF Deziel, Nicole C. Freeman, Laura E. Beane Graubard, Barry I. Jones, Rena R. Hoppin, Jane A. Thomas, Kent Hines, Cynthia J. Blair, Aaron Sandler, Dale P. Chen, Honglei Lubin, Jay H. Andreotti, Gabriella Alavanja, Michael C. R. Friesen, Melissa C. TI Relative Contributions of Agricultural Drift, Para-Occupational, and Residential Use Exposure Pathways to House Dust Pesticide Concentrations: Meta-Regression of Published Data SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Review ID CHILDRENS EXPOSURE; CARPET DUST; HOME; CONTAMINATION; PROXIMITY; COMMUNITY; FAMILIES; FARM; IOWA; VARIABILITY AB Background: Increased pesticide concentrations in house dust in agricultural areas have been attributed to several exposure pathways, including agricultural drift, para-occupational, and residential use. Objective: To guide future exposure assessment efforts, we quantified relative contributions of these pathways using meta-regression models of published data on dust pesticide concentrations. Methods: From studies in North American agricultural areas published from 1995 to 2015, we abstracted dust pesticide concentrations reported as summary statistics [e.g., geometric means (GM)]. We analyzed these data using mixed-effects meta-regression models that weighted each summary statistic by its inverse variance. Dependent variables were either the log-transformed GM (drift) or the log-transformed ratio of GMs from two groups (para-occupational, residential use). Results: For the drift pathway, predicted GMs decreased sharply and nonlinearly, with GMs 64% lower in homes 250 m versus 23 m from fields (interquartile range of published data) based on 52 statistics from seven studies. For the para-occupational pathway, GMs were 2.3 times higher [95% confidence interval (CI): 1.5, 3.3; 15 statistics, five studies] in homes of farmers who applied pesticides more recently or frequently versus less recently or frequently. For the residential use pathway, GMs were 1.3 (95% CI: 1.1, 1.4) and 1.5 (95% CI: 1.2, 1.9) times higher in treated versus untreated homes, when the probability that a pesticide was used for the pest treatment was 1-19% and >= 20%, respectively (88 statistics, five studies). Conclusion: Our quantification of the relative contributions of pesticide exposure pathways in agricultural populations could improve exposure assessments in epidemiologic studies. The meta-regression models can be updated when additional data become available. Citation: Deziel NC, Beane Freeman LE, Graubard BI, Jones RR, Hoppin JA, Thomas K, Hines CJ, Blair A, Sandler DP, Chen H, Lubin JH, Andreotti G, Alavanja MC, Friesen MC. 2017. Relative contributions of agricultural drift, para-occupational, and residential use exposure pathways to house dust pesticide concentrations: meta-regression of published data. Environ Health Perspect 125:296-305; http://dx.doi.org/10.1289/EHP426 C1 [Deziel, Nicole C.; Freeman, Laura E. Beane; Graubard, Barry I.; Jones, Rena R.; Blair, Aaron; Lubin, Jay H.; Andreotti, Gabriella; Alavanja, Michael C. R.; Friesen, Melissa C.] NCI, Div Canc Epidemiol & Genet, NIH, US Dept HHS, Bethesda, MD 20892 USA. [Deziel, Nicole C.] Yale Univ, Yale Sch Publ Hlth, Dept Environm Hlth Sci, New Haven, CT USA. [Hoppin, Jane A.] North Carolina State Univ, Ctr Human Hlth & Environm, Dept Biol Sci, Raleigh, NC USA. [Thomas, Kent] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Hines, Cynthia J.] NIOSH, Div Surveillance Hazard Evaluat & Field Studi, Cincinnati, OH 45226 USA. [Sandler, Dale P.; Chen, Honglei] NIEHS, Epidemiol Branch, NIH, US Dept HHS, Res Triangle Pk, NC 27709 USA. RP Deziel, NC (reprint author), Yale Sch Publ Hlth, 60 Coll St, New Haven, CT 06510 USA. EM nicole.deziel@yale.edu RI Friesen, Melissa/A-5362-2009; Beane Freeman, Laura/C-4468-2015; OI Beane Freeman, Laura/0000-0003-1294-4124; Chen, Honglei/0000-0003-3446-7779 FU Intramural Research Program of the National Institutes of Health, National Cancer Institute (NCI), Division of Cancer Epidemiology and Genetics [Z01CP010119]; National Institute of Environmental Health Sciences [Z01-ES049030]; NCI [HHSN261201400231P] FX This work was supported by the Intramural Research Program of the National Institutes of Health, National Cancer Institute (NCI), Division of Cancer Epidemiology and Genetics (Z01CP010119), and the National Institute of Environmental Health Sciences (Z01-ES049030). N.C.D. was supported, in part, through NCI (HHSN261201400231P). The U.S. Environmental Protection Agency through its Office of Research and Development collaborated in the research described here. It has been subjected to agency review and approved for publication. NR 40 TC 0 Z9 0 U1 0 U2 0 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD MAR PY 2017 VL 125 IS 3 BP 296 EP 305 DI 10.1289/EHP426 PG 10 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA EN0QL UT WOS:000395714400009 PM 27458779 ER PT J AU Penn, SL Arunachalam, S Woody, M Heiger-Bernays, W Tripodis, Y Levy, JI AF Penn, Stefani L. Arunachalam, Saravanan Woody, Matthew Heiger-Bernays, Wendy Tripodis, Yorghos Levy, Jonathan I. TI Estimating State-Specific Contributions to PM2.5- and O-3-Related Health Burden from Residential Combustion and Electricity Generating Unit Emissions in the United States SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article ID DECOUPLED DIRECT METHOD; PARTICULATE AIR-POLLUTION; SENSITIVITY-ANALYSIS; CLIMATE-CHANGE; QUALITY MODEL; EARLY DEATHS; MORTALITY; OZONE; IMPACT; MATTER AB Background: Residential combustion (RC) and electricity generating unit (EGU) emissions adversely impact air quality and human health by increasing ambient concentrations of fine particulate matter (PM2.5) and ozone (O-3). Studies to date have not isolated contributing emissions by state of origin (source-state), which is necessary for policy makers to determine efficient strategies to decrease health impacts. Objectives: In this study, we aimed to estimate health impacts (premature mortalities) attributable to PM2.5 and O-3 from RC and EGU emissions by precursor species, source sector, and source-state in the continental United States for 2005. Methods: We used the Community Multiscale Air Quality model employing the decoupled direct method to quantify changes in air quality and epidemiological evidence to determine concentration-response functions to calculate associated health impacts. Results: We estimated 21,000 premature mortalities per year from EGU emissions, driven by sulfur dioxide emissions forming PM2.5.- More than half of EGU health impacts are attributable to emissions from eight states with significant coal combustion and large downwind populations. We estimate 10,000 premature mortalities per year from RC emissions, driven by primary PM2.5- emissions. States with large populations and significant residential wood combustion dominate RC health impacts. Annual mortality risk per thousand tons of precursor emissions (health damage functions) varied significantly across source-states for both source sectors and all precursor pollutants. Conclusions: Our findings reinforce the importance of pollutant-specific, location-specific, and source-specific models of health impacts in design of health-risk minimizing emissions control policies. C1 [Penn, Stefani L.; Heiger-Bernays, Wendy; Levy, Jonathan I.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, 715 Albany St 4W, Boston, MA 02118 USA. [Arunachalam, Saravanan; Woody, Matthew] Univ N Carolina, Inst Environm, Chapel Hill, NC USA. [Woody, Matthew] US EPA, Durham, NC USA. [Tripodis, Yorghos] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA. RP Penn, SL (reprint author), Boston Univ, Sch Publ Hlth, Dept Environm Hlth, 715 Albany St 4W, Boston, MA 02118 USA. EM stefani.penn@gmail.com FU North American Insulation Manufacturers Association (NAIMA) FX This research was supported by the North American Insulation Manufacturers Association (NAIMA). NR 36 TC 0 Z9 0 U1 3 U2 3 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD MAR PY 2017 VL 125 IS 3 BP 324 EP 332 DI 10.1289/EHP550 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA EN0QL UT WOS:000395714400011 PM 27586513 ER PT J AU Jian, Y Messer, LC Jagai, JS Rappazzo, KM Gray, CL Grabich, SC Lobdell, DT AF Jian, Yun Messer, Lynne C. Jagai, Jyotsna S. Rappazzo, Kristen M. Gray, Christine L. Grabich, Shannon C. Lobdell, Danelle T. TI Associations between Environmental Quality and Mortality in the Contiguous United States, 2000-2005 SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article ID CANCER-SOCIETY COHORT; HAZARDOUS-WASTE; AIR-POLLUTION; US COUNTIES; HEALTH; INEQUALITIES; DEPRIVATION; PREVALENCE; PATTERNS; JUSTICE AB Background: Assessing cumulative effects of the multiple environmental factors influencing mortality remains a challenging task. Objectives: This study aimed to examine the associations between cumulative environmental quality and all-cause and leading cause-specific (heart disease, cancer, and stroke) mortality rates. Methods: We used the overall Environmental Quality Index (EQI) and its five domain indices (air, water, land, built, and sociodemographic) to represent environmental exposure. Associations between the EQI and mortality rates (CDC WONDER) for counties in the contiguous United States (n = 3,109) were investigated using multiple linear regression models and random intercept and random slope hierarchical models. Urbanicity, climate, and a combination of the two were used to explore the spatial patterns in the associations. Results: We found 1 standard deviation increase in the overall EQI (worse environment) was associated with a mean 3.22% (95% CI: 2.80%, 3.64%) increase in all-cause mortality, a 0.54%(95% CI: -0.17%, 1.25%) increase in heart disease mortality, a 2.71% (95% CI: 2.21%, 3.22%) increase in cancer mortality, and a 2.25% (95% CI: 1.11%, 3.39%) increase in stroke mortality. Among the environmental domains, the associations ranged from -1.27% (95% CI: -1.70%, -0.84%) to 3.37% (95% CI: 2.90%, 3.84%) for all-cause mortality, -2.62% (95% CI: -3.52%, -1.73%) to 4.50% (95% CI: 3.73%, 5.27%) for heart disease mortality, -0.88% (95% CI: -2.12%, 0.36%) to 3.72% (95% CI: 2.38%, 5.06%) for stroke mortality, and -0.68% (95% CI: -1.19%, -0.18%) to 3.01% (95% CI: 2.46%, 3.56%) for cancer mortality. Air had the largest associations with all-cause, heart disease, and cancer mortality, whereas the socio-demographic index had the largest association with stroke mortality. Across the urbanicity gradient, no consistent trend was found. Across climate regions, the associations ranged from 2.29% (95% CI: 1.87%, 2.72%) to 5.30% (95% CI: 4.30%, 6.30%) for overall EQI, and larger associations were generally found in dry areas for both overall EQI and domain indices. Conclusions: These results suggest that poor environmental quality, particularly poor air quality, was associated with increased mortality and that associations vary by urbanicity and climate region. C1 [Jian, Yun; Gray, Christine L.] US EPA, Oak Ridge Inst Sci & Educ, NHEERL, Chapel Hill, NC USA. [Messer, Lynne C.] Portland State Univ, Coll Urban & Publ Affairs, Sch Community Hlth, Portland, OR 97207 USA. [Jagai, Jyotsna S.] Univ Illinois, Sch Publ Hlth, Div Environm & Occupat Hlth Sci, Chicago, IL USA. [Rappazzo, Kristen M.; Grabich, Shannon C.; Lobdell, Danelle T.] US EPA, NHEERL, Chapel Hill, NC USA. [Gray, Christine L.] UNC Gillings, Sch Global Publ Hlth, Chapel Hill, NC USA. RP Lobdell, DT (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, MD 58A, Res Triangle Pk, NC 27711 USA. EM lobdell.danelle@epa.gov FU U.S. Environmental Protection Agency (EPA) Office of Research and Development (ORD) [EP12D000264, EP09D000003]; Internship/Research Participation Program at Office of Research and Development (NHEERL); U.S. EPA FX The U.S. Environmental Protection Agency (EPA) Office of Research and Development (ORD) partially funded the research with L.C.M. (contracts EP12D000264 and EP09D000003); Y.J., J.S.J., and C.L.G. were supported in part by an appointment to the Internship/Research Participation Program at Office of Research and Development (NHEERL), U.S. EPA, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and the U.S. EPA. NR 38 TC 0 Z9 0 U1 0 U2 0 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD MAR PY 2017 VL 125 IS 3 BP 355 EP 362 DI 10.1289/EHP119 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA EN0QL UT WOS:000395714400015 PM 27713110 ER PT J AU Wang, JD Xing, J Mathur, R Pleim, JE Wang, SX Hogrefe, C Gan, CM Wong, DC Hao, JM AF Wang, Jiandong Xing, Jia Mathur, Rohit Pleim, Jonathan E. Wang, Shuxiao Hogrefe, Christian Gan, Chuen-Meei Wong, David C. Hao, Jiming TI Historical Trends in PM2.5-Related Premature Mortality during 1990-2010 across the Northern Hemisphere SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article ID PARTICULATE AIR-POLLUTION; LONG-TERM EXPOSURE; GLOBAL BURDEN; UNITED-STATES; SYSTEMATIC ANALYSIS; CHINA; DISEASE; AEROSOL; MATTER; MODEL AB BACKGROUND: Air quality across the northern hemisphere over the past two decades has witnessed dramatic changes, with continuous improvement in developed countries in North America and Europe, but a contrasting sharp deterioration in developing regions of Asia. OBJECTIVE: This study investigates the historical trend in the long-term exposure to PM2.5 and PM2.5-related premature mortality (PM2.5-mortality) and its response to changes in emission that occurred during 1990-2010 across the northern hemisphere. Implications for future trends in human exposure to air pollution in both developed and developing regions of the world are discussed. METHODS: We employed the integrated exposure-response model developed by Health Effects Institute to estimate the PM2.5-mortality. The 1990-2010 annual average PM2.5 concentrations were obtained from the simulations using the WRF-CMAQ model. Emission mitigation efficiencies of sulfur dioxide (SO2), nitrogen oxides (NOx), ammonia (NH3), and primary PM are estimated from the PM2.5-mortality responses to the emission variations. RESULTS: Estimated PM2.5-mortalities in East Asia and South Asia increased by 21% and 85% respectively, from 866,000 and 578,000 in 1990, to 1,048,000 and 1,068,000 in 2010. PM2.5-mortalities in developed regions (i.e., Europe and high-income North America) decreased substantially by 67% and 58% respectively. CONCLUSIONS: Over the past two decades, correlations between population and PM2.5 have become weaker in Europe and North America due to air pollution controls but stronger in East Asia due to deteriorating air quality. Mitigation of primary PM appears to be the most efficient way for increasing health benefits (i.e., providing the largest mortality reduction per unit emissions). However, reductions in emissions of NH3 are needed to maximize the effectiveness of NOx emission controls. C1 [Wang, Jiandong; Xing, Jia; Mathur, Rohit; Pleim, Jonathan E.; Hogrefe, Christian; Gan, Chuen-Meei; Wong, David C.] US EPA, Res Triangle Pk, NC 27711 USA. [Wang, Jiandong; Xing, Jia; Wang, Shuxiao; Hao, Jiming] Tsinghua Univ, Sch Environm, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100084, Peoples R China. RP Wang, SX (reprint author), Tsinghua Univ, Sch Environm, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100084, Peoples R China.; Mathur, R (reprint author), US EPA, Natl Exposure Res Lab, 109 TW Alexander Dr,MD E243-02, Res Triangle Pk, NC 27711 USA. EM Mathur.Rohit@epa.gov; shxwang@tsinghua.edu FU Department of Energy [DESC0003782]; U.S. EPA [RW-8992332601]; MEP's ( Migrant Education Program) Special Funds for Research on Public Welfare [201409002]; Strategic Priority Research Program of the Chinese Academy of Sciences [XDB05020300]; National Research Council post-doctoral fellowships FX This work was supported in part by an interagency agreement between the Department of Energy (DESC0003782) and the U.S. EPA (RW-8992332601) and by the MEP's ( Migrant Education Program) Special Funds for Research on Public Welfare (201409002) and the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB05020300). During the conduct of this work, J.X. and C.-M.G. held National Research Council post-doctoral fellowships, and J.W. was a visiting student at the U.S. EPA. NR 37 TC 0 Z9 0 U1 1 U2 1 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD MAR PY 2017 VL 125 IS 3 BP 400 EP 408 DI 10.1289/EHP298 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA EN0QL UT WOS:000395714400021 PM 27539607 ER PT J AU Burke, TA Cascio, WE Costa, DL Deener, K Fontaine, TD Fulk, FA Jackson, LE Munns, WR Orme-Zavaleta, J Slimak, MW Zartarian, VG AF Burke, Thomas A. Cascio, Wayne E. Costa, Daniel L. Deener, Kacee Fontaine, Thomas D. Fulk, Florence A. Jackson, Laura E. Munns, Wayne R., Jr. Orme-Zavaleta, Jennifer Slimak, Michael W. Zartarian, Valerie G. TI Rethinking Environmental Protection: Meeting the Challenges of a Changing World SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article ID ECOSYSTEM SERVICES; HEALTH; WILDFIRE; LAND; RISK; ASSESSMENTS; MANAGEMENT; FRAMEWORK; POLLUTION; EXPOSURE AB From climate change to hydraulic fracturing, and from drinking water safety to wildfires, environmental challenges are changing. The United States has made substantial environmental protection progress based on media-specific and single pollutant risk-based frameworks. However, today's environmental problems are increasingly complex and new scientific approaches and tools are needed to achieve sustainable solutions to protect the environment and public health. In this article, we present examples of today's environmental challenges and offer an integrated systems approach to address them. We provide a strategic framework and recommendations for advancing the application of science for protecting the environment and public health. We posit that addressing 21st century challenges requires transdisciplinary and systems approaches, new data sources, and stakeholder partnerships. To address these challenges, we outline a process driven by problem formulation with the following steps: a) formulate the problem holistically, b) gather and synthesize diverse information, c) develop and assess options, and d) implement sustainable solutions. This process will require new skills and education in systems science, with an emphasis on science translation. A systems-based approach can transcend media- and receptor-specific bounds, integrate diverse information, and recognize the inextricable link between ecology and human health. C1 [Burke, Thomas A.; Cascio, Wayne E.; Costa, Daniel L.; Deener, Kacee; Fontaine, Thomas D.; Fulk, Florence A.; Jackson, Laura E.; Munns, Wayne R., Jr.; Orme-Zavaleta, Jennifer; Slimak, Michael W.; Zartarian, Valerie G.] US EPA, Off Res & Dev, Washington, DC 20460 USA. RP Deener, K (reprint author), Ronald Reagan Bldg,1300 Penn Ave NW,Room 41207, Washington, DC 20004 USA. EM Deener.kathleen@epa.gov NR 60 TC 0 Z9 0 U1 2 U2 2 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD MAR PY 2017 VL 125 IS 3 BP A43 EP A49 DI 10.1289/EHP1465 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA EN0QL UT WOS:000395714400001 PM 28248180 ER PT J AU Strickland, J Zang, QD Paris, M Lehmann, DM Allen, D Choksi, N Matheson, J Jacobs, A Casey, W Kleinstreuer, N AF Strickland, Judy Zang, Qingda Paris, Michael Lehmann, David M. Allen, David Choksi, Neepa Matheson, Joanna Jacobs, Abigail Casey, Warren Kleinstreuer, Nicole TI Multivariate models for prediction of human skin sensitization hazard SO JOURNAL OF APPLIED TOXICOLOGY LA English DT Article DE Skin sensitization; allergic contact dermatitis (ACD); integrated decision strategy; machine learning; LLNA; DPRA; KeratinoSens; h-CLAT ID LYMPH-NODE ASSAY; LINE ACTIVATION TEST; TEST H-CLAT; IN-VITRO METHODS; SCREENING CONTACT ALLERGENS; INTEGRATED TESTING STRATEGY; PEPTIDE REACTIVITY ASSAY; RISK-ASSESSMENT MODEL; ICCVAM EVALUATION; RANDOM FOREST AB One of the Interagency Coordinating Committee on the Validation of Alternative Method's (ICCVAM) top priorities is the development and evaluation of non-animal approaches to identify potential skin sensitizers. The complexity of biological events necessary to produce skin sensitization suggests that no single alternative method will replace the currently accepted animal tests. ICCVAM is evaluating an integrated approach to testing and assessment based on the adverse outcome pathway for skin sensitization that uses machine learning approaches to predict human skin sensitization hazard. We combined data from three in chemico or in vitro assays - the direct peptide reactivity assay (DPRA), human cell line activation test (h-CLAT) and KeratinoSens assay - six physicochemical properties and an in silico read-across prediction of skin sensitization hazard into 12 variable groups. The variable groups were evaluated using two machine learning approaches, logistic regression and support vector machine, to predict human skin sensitization hazard. Models were trained on 72 substances and tested on an external set of 24 substances. The six models (three logistic regression and three support vector machine) with the highest accuracy (92%) used: (1) DPRA, h-CLAT and read-across; (2) DPRA, h-CLAT, read-across and KeratinoSens; or (3) DPRA, h-CLAT, read-across, KeratinoSens and log P. The models performed better at predicting human skin sensitization hazard than the murine local lymph node assay (accuracy 88%), any of the alternative methods alone (accuracy 63-79%) or test batteries combining data from the individual methods (accuracy 75%). These results suggest that computational methods are promising tools to identify effectively the potential human skin sensitizers without animal testing. Published 2016. This article has been contributed to by US Government employees and their work is in the public domain in the USA. The Interagency Coordinating Committee on the Validation of Alternative Methods evaluated a non-animal decision strategy using machine learning approaches to integrate in vitro, in chemico and in silico data and physicochemical properties to predict human skin sensitization hazard for 96 substances. The six most accurate models used different combinations of variables and outperformed the local lymph node assay and individual non-animal methods. Results of this evaluation suggest that computational approaches are promising tools to integrate data effectively to identify potential sensitizers without animal testing. C1 [Strickland, Judy; Zang, Qingda; Paris, Michael; Allen, David; Choksi, Neepa] ILS, POB 13501, Res Triangle Pk, NC 27709 USA. [Lehmann, David M.] US FDA, Res Triangle Pk, NC 27709 USA. [Casey, Warren; Kleinstreuer, Nicole] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC 27709 USA. [Matheson, Joanna] US Consumer Prod Safety Commiss, Rockville, MD 20850 USA. [Jacobs, Abigail] US FDA, Silver Spring, MD USA. RP Strickland, J (reprint author), ILS, POB 13501, Res Triangle Pk, NC 27709 USA. EM strickl2@niehs.nih.gov FU NIEHS, NIH of the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods [HHSN273201500010C] FX The authors thank Drs. R. Luebke, M. Ward, D. Germolec and B.A. Merrick for their thoughtful critical review of this manuscript. This project was funded in whole or in part with federal funds from the NIEHS, NIH under contract HHSN273201500010C to ILS in support of the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods. NR 69 TC 2 Z9 2 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0260-437X EI 1099-1263 J9 J APPL TOXICOL JI J. Appl. Toxicol. PD MAR PY 2017 VL 37 IS 3 BP 347 EP 360 DI 10.1002/jat.3366 PG 14 WC Toxicology SC Toxicology GA EL2BR UT WOS:000394425600011 PM 27480324 ER PT J AU Lin, MY Horowitz, LW Payton, R Fiore, AM Tonnesen, G AF Lin, Meiyun Horowitz, Larry W. Payton, Richard Fiore, Arlene M. Tonnesen, Gail TI US surface ozone trends and extremes from 1980 to 2014: quantifying the roles of rising Asian emissions, domestic controls, wildfires, and climate SO ATMOSPHERIC CHEMISTRY AND PHYSICS LA English DT Article ID WESTERN NORTH-AMERICA; LONG-TERM CHANGES; UNITED-STATES; AIR-QUALITY; TROPOSPHERIC OZONE; SUMMERTIME OZONE; EAST-ASIA; SIGNIFICANT INCREASE; MIXING RATIOS; GLOBAL-MODELS AB US surface O-3 responds to varying global-toregional precursor emissions, climate, and extreme weather, with implications for designing effective air quality control policies. We examine these conjoined processes with observations and global chemistry-climate model (GFDL-AM3) hindcasts over 1980-2014. The model captures the salient features of observed trends in daily maximum 8 h average O-3: (1) increases over East Asia (up to 2 ppb yr(-1)), (2) springtime increases at western US (WUS) rural sites (0.2-0.5 ppb yr(-1)) with a baseline sampling approach, and (3) summertime decreases, largest at the 95th percentile, and wintertime increases in the 50th to 5th percentiles over the eastern US (EUS). Asian NOx emissions have tripled since 1990, contributing as much as 65% to modeled springtime background O-3 increases (0.3-0.5 ppb yr(-1)) over the WUS, outpacing O-3 decreases attained via 50% US NOx emission controls. Methane increases over this period contribute only 15% of the WUS background O-3 increase. Springtime O-3 observed in Denver has increased at a rate similar to remote rural sites. During summer, increasing Asian emissions approximately offset the benefits of US emission reductions, leading to weak or insignificant observed O-3 trends at WUS rural sites. Mean springtime WUS O-3 is projected to increase by similar to 10 ppb from 2010 to 2030 under the RCP8.5 global change scenario. While historical wildfire emissions can enhance summertime monthly mean O-3 at individual sites by 2-8 ppb, high temperatures and the associated buildup of O-3 produced from regional anthropogenic emissions contribute most to elevating observed summertime O-3 throughout the USA. GFDL-AM3 captures the observed interannual variability of summertime EUS O-3. However, O-3 deposition sink to vegetation must be reduced by 35% for the model to accurately simulate observed high-O-3 anomalies during the severe drought of 1988. Regional NOx reductions alleviated the O-3 buildup during the recent heat waves of 2011 and 2012 relative to earlier heat waves (e.g., 1988, 1999). The O-3 decreases driven by NOx controls were more pronounced in the southeastern US, where the seasonal onset of biogenic isoprene emissions and NOx -sensitive O-3 production occurs earlier than in the northeast. Without emission controls, the 95th percentile summertime O-3 in the EUS would have increased by 0.2-0.4 ppb yr(-1) over 1988-2014 due to more frequent hot extremes and rising biogenic isoprene emissions. C1 [Lin, Meiyun] Princeton Univ, Atmospher & Ocean Sci, Princeton, NJ 08540 USA. [Lin, Meiyun; Horowitz, Larry W.] NOAA, Geophys Fluid Dynam Lab, Princeton, NJ 08540 USA. [Payton, Richard; Tonnesen, Gail] US EPA, Air Program, Reg 8, Denver, CO 80202 USA. [Fiore, Arlene M.] Columbia Univ, Lamont Doherty Earth Observ, Palisades, NY 10964 USA. [Fiore, Arlene M.] Columbia Univ, Dept Earth & Environm Sci, Palisades, NY 10964 USA. RP Lin, MY (reprint author), Princeton Univ, Atmospher & Ocean Sci, Princeton, NJ 08540 USA.; Lin, MY (reprint author), NOAA, Geophys Fluid Dynam Lab, Princeton, NJ 08540 USA. EM meiyun.lin@noaa.gov OI Lin, Meiyun/0000-0003-3852-3491 FU NASA [NNH13ZDA001N-AURAST, NNX14AR47G]; EPA Assistance Agreement [83587801] FX This work was supported by funding from NASA grants NNH13ZDA001N-AURAST and NNX14AR47G to Meiyun Lin. We thank O. Cooper, S. Fan and J. Schnell for helpful comments on the manuscript. We acknowledge the free use of ozonesonde data at Hong Kong available on www.woudc.org and GOME-SCIAMACHY tropospheric NO2 column data available on www.temis.nl. Arlene M. Fiore acknowledges support under EPA Assistance Agreement no. 83587801. The views expressed in this document are solely those of the authors and do not necessarily reflect those of the agency. Meiyun Lin devotes this article to her father Tianci Lin, who is the motivation of her life and research career. NR 107 TC 1 Z9 1 U1 5 U2 5 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1680-7316 EI 1680-7324 J9 ATMOS CHEM PHYS JI Atmos. Chem. Phys. PD MAR 1 PY 2017 VL 17 IS 4 BP 2943 EP 2970 DI 10.5194/acp-17-2943-2017 PG 28 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA EM2AI UT WOS:000395118400001 ER PT J AU Ashley, PJ Freemer, M Garbe, P Rowson, D AF Ashley, Peter J. Freemer, Michelle Garbe, Paul Rowson, David TI Coordinated Federal Actions Are Needed to Reduce Racial and Ethnic Disparities in Childhood Asthma SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Editorial Material C1 [Ashley, Peter J.] US Dept Housing & Urban Dev, 451 7th St,SW,Room 8236, Washington, DC 20410 USA. [Freemer, Michelle] NHLBI, Bldg 10, Bethesda, MD 20892 USA. [Garbe, Paul] Ctr Dis Control & Prevent, Atlanta, GA USA. [Rowson, David] US EPA, Washington, DC 20460 USA. RP Ashley, PJ (reprint author), US Dept Housing & Urban Dev, 451 7th St,SW,Room 8236, Washington, DC 20410 USA. EM Peter.J.Ashley@hud.gov NR 4 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1078-4659 EI 1550-5022 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD MAR-APR PY 2017 VL 23 IS 2 BP 207 EP 209 DI 10.1097/PHH.0000000000000541 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA EK1WM UT WOS:000393716500025 PM 28121772 ER PT J AU Haninger, K Ma, L Timmins, C AF Haninger, Kevin Ma, Lala Timmins, Christopher TI The Value of Brownfield Remediation SO JOURNAL OF THE ASSOCIATION OF ENVIRONMENTAL AND RESOURCE ECONOMISTS LA English DT Article DE Brownfields; Difference in differences; Nearest neighbor matching; Property value hedonics ID HAZARDOUS-WASTE SITES; PROPERTY-VALUES; ENVIRONMENTAL JUSTICE; IMPACT; MARKETS; CRIME AB The US Environmental Protection Agency Brownfields Program awards grants to redevelop contaminated lands known as brownfields. This paper estimates cleanup benefits by combining administrative records for a nationally representative sample of brownfields with high-resolution, high-frequency housing data. With cleanup, we find that property values increase by an average of 5.0% to 11.5%. For a welfare interpretation that does not rely on the intertemporal stability of the hedonic price function, a double-difference matching estimator finds even larger effects of up to 15.2%. Our various specifications lead to the consistent conclusion that Brownfields Program cleanups yield positive, statistically significant, but highly localized effects on housing prices. C1 [Haninger, Kevin] US EPA, 1200 Penn Ave NW, Washington, DC 20460 USA. [Haninger, Kevin] AAAS, 1200 Penn Ave NW, Washington, DC 20460 USA. [Ma, Lala] Univ Kentucky, Dept Econ, Business & Econ Bldg, Lexington, KY 40506 USA. [Timmins, Christopher] Duke Univ, Dept Econ, Durham, NC 27708 USA. [Timmins, Christopher] Natl Bur Econ Res, Social Sci Bldg,POB 90097, Durham, NC 27708 USA. RP Timmins, C (reprint author), Duke Univ, Dept Econ, Durham, NC 27708 USA.; Timmins, C (reprint author), Natl Bur Econ Res, Social Sci Bldg,POB 90097, Durham, NC 27708 USA. EM kevin.haninger@gmail.com; lala.ma@uky.edu; christopher.timmins@duke.edu FU US Environmental Protection Agency (EPA) Office of Land and Emergency Response Center for Program Analysis; Office of Brownfields and Land Revitalization (OBLR); EPA Regional Offices FX We gratefully acknowledge the US Environmental Protection Agency (EPA) Office of Land and Emergency Response Center for Program Analysis, the Office of Brownfields and Land Revitalization (OBLR), and EPA Regional Offices for providing financial support, program expertise, and access to the data. We especially thank Ryan Smith of the OBLR for his partnership. We would also like to thank seminar participants at Iowa State University, University of Kentucky, and Center for Environmental and Resource Economic Policy Camp Resources for helpful comments. Any opinions and conclusions expressed herein are ours and do not necessarily represent the views of the EPA or the National Bureau of Economic Research. This work was conducted while Kevin Haninger was an AAAS Policy Fellow at the EPA. All errors are our own. NR 39 TC 0 Z9 0 U1 5 U2 5 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 2333-5955 EI 2333-5963 J9 J ASSOC ENVIRON RESO JI J. Assoc. Environ. Resour. Econ. PD MAR PY 2017 VL 4 IS 1 BP 197 EP 241 DI 10.1086/689743 PG 45 WC Economics SC Business & Economics GA EK2UL UT WOS:000393782100006 ER PT J AU Wohlleben, W Kingston, C Carter, J Sahle-Demessie, E Vazquez-Campos, S Acrey, B Chen, CY Walton, E Egenolf, H Muller, P Zepp, R AF Wohlleben, Wendel Kingston, Christopher Carter, Janet Sahle-Demessie, E. Vazquez-Campos, Socorro Acrey, Brad Chen, Chia-Ying Walton, Ernest Egenolf, Heiko Mueller, Philipp Zepp, Richard TI NanoRelease: Pilot interlaboratory comparison of a weathering protocol applied to resilient and labile polymers with and without embedded carbon nanotubes SO CARBON LA English DT Article ID LIFE-CYCLE; USE PHASE; RELEASE; NANOCOMPOSITES; NANOMATERIALS; NANOPARTICLES; IRRADIATION; COMPOSITES; SCENARIOS AB A major use of multi-walled carbon nanotubes (MWCNTs) is as functional fillers embedded in a solid matrix, such as plastics or coatings. Weathering and abrasion of the solid matrix during use can lead to environmental releases of the MWCNTs. Here we focus on a protocol to identify and quantify the primary release induced by weathering, and assess reproducibility, transferability, and sensitivity towards different materials and uses. We prepared 132 specimens of two polymer-MWCNT composites containing the same grade of MWCNTs used in earlier OECD hazard assessments but without UV stabilizer. We report on a pilot inter-laboratory comparison (TLC) with four labs (two US and two EU) aging by UV and rain, then shipping for analysis. Two labs (one US and one EU) conducted the release sampling and analysis by Transmission Electron Microscopy (TEM), Inductively Coupled Plasma-Mass Spectrometry (ICP-MS), Ultraviolet Visible Spectroscopy (UV-Vis), Analytical Ultracentrifugation (AUC), and Asymmetric Flow Field Flow Fractionation (AF4). We compare results between aging labs, between analysis labs and between materials. Surprisingly, we found quantitative agreement between analysis labs for TEM, ICP-MS, UV-Vis; low variation between aging labs by all methods; and consistent rankings of release between TEM, ICP-MS, UV-Vis, AUC. Significant disagreement was related primarily to differences in aging, but even these cases remained within a factor of two. (C) 2016 Published by Elsevier Ltd. C1 [Wohlleben, Wendel; Egenolf, Heiko; Mueller, Philipp] BASF SE, Dept Mat Phys & Analyt, D-67056 Ludwigshafen, Germany. [Kingston, Christopher] Natl Res Council Canada, Ottawa, ON, Canada. [Carter, Janet] OSHA, Washington, DC USA. [Sahle-Demessie, E.] US EPA, Off Res & Dev, NRMRL, Cincinnati, OH 45268 USA. [Vazquez-Campos, Socorro] LEITAT Technol Ctr, C7 Innovacio 2, Barcelona 08225, Spain. [Acrey, Brad; Chen, Chia-Ying; Zepp, Richard] US EPA, ORD, NERL, 960 Coll Stn Rd, Athens, GA 30605 USA. [Walton, Ernest] US EPA, SESD, Reg 4, Athens, GA USA. [Acrey, Brad] Student Serv Associate, Houston, TX USA. [Chen, Chia-Ying] Natl Res Council Associate, Houston, TX USA. EM Zepp.Richard@epa.gov NR 42 TC 0 Z9 0 U1 7 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0008-6223 EI 1873-3891 J9 CARBON JI Carbon PD MAR PY 2017 VL 113 BP 346 EP 360 DI 10.1016/j.carbon.2016.11.011 PG 15 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA EI7OC UT WOS:000392686600041 ER PT J AU Gonzalez-Mejia, AM Ma, X AF Gonzalez-Mejia, Alejandra M. Ma, Xin (Cissy) TI The Emergy Perspective of Sustainable Trends in Puerto Rico From 1960 to 2013 SO ECOLOGICAL ECONOMICS LA English DT Article DE Sustainability; Environmental accounting; Import-export balance; Energy system; Emergy indicators ID SAN-LUIS BASIN; REGIONAL SUSTAINABILITY; COLORADO AB Emergy analysis quantifies the direct and indirect contributions of nature to human systems providing a sustain ability assessment framework, which couples economic growth within biophysical constraints. In this study, Puerto Rico's sustainability was assessed with emergy flow dynamics from 1960 to 2013. During this period, the island shifted from an agriculture-based economy to an industrial base of manufacture and services (1960-1970). The emergy analysis indicated an exponential decline in sustainability during this period. From 1975 to 1992, the island became more industrialized and imported more goods and services. Since 1998, although more renewable production such as forest regeneration occurred, the rapid industrialization heavily relied on imported fossil fuels, goods, and services, resulting in a system that has not been self-sufficient, nor sustainable. The latest economic crisis and the most recently passed financial rescue bill represent an opportunity to redirect Puerto Rico towards a sustainable path with policies that decrease the ratio of imported y to exported emergy, and strategies that encourage efficient use of resources and local production based on the utilization of renewable sources within this U.S. territory. (C) 2015 Published by Elsevier B.V. C1 [Gonzalez-Mejia, Alejandra M.; Ma, Xin (Cissy)] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Sustainable Technol Div, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. [Gonzalez-Mejia, Alejandra M.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Gonzalez-Mejia, Alejandra M.] Nat Resources & Geog SENRGy, Ser Cymru Natl Res Network Low Carbon Energy & En, Sch Environm, Deiniol Rd, Bangor LL57 2UW, Gwynedd, Wales. RP Ma, X (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Sustainable Technol Div, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM a.g.mejia@bangor.ac.uk; ma.cissy@epa.gov FU U.S. Environmental Protection Agency, Office of Research and Development through the Oak Ridge Institute for Science and Education Post-Doctoral Fellowship Program FX This project was supported by the U.S. Environmental Protection Agency, Office of Research and Development through the Oak Ridge Institute for Science and Education Post-Doctoral Fellowship Program. We thank Z. Morris for assisting in data organization and proof, Pamela Vierheller for tracking down the valuable multiple years of External Trade Statistics, D. Campbell for providing data and thoughtful discussions, M. Hopton, L. Vance, T. Eason, and H. Cabezas for helpful comments. NR 60 TC 1 Z9 1 U1 15 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0921-8009 EI 1873-6106 J9 ECOL ECON JI Ecol. Econ. PD MAR PY 2017 VL 133 BP 11 EP 22 DI 10.1016/j.ecolecon.2016.11.007 PG 12 WC Ecology; Economics; Environmental Sciences; Environmental Studies SC Environmental Sciences & Ecology; Business & Economics GA EH8RI UT WOS:000392039600002 ER PT J AU Solazzo, E Bianconi, R Hogrefe, C Curci, G Tuccella, P Alyuz, U Balzarini, A Baro, R Bellasio, R Bieser, J Brandt, J Christensen, JH Colette, A Francis, X Fraser, A Vivanco, MG Jimenez-Guerrero, P Im, U Manders, A Nopmongcol, U Kitwiroon, N Pirovano, G Pozzoli, L Prank, M Sokhi, RS Unal, A Yarwood, G Galmarini, S AF Solazzo, Efisio Bianconi, Roberto Hogrefe, Christian Curci, Gabriele Tuccella, Paolo Alyuz, Ummugulsum Balzarini, Alessandra Baro, Rocio Bellasio, Roberto Bieser, Johannes Brandt, Jorgen Christensen, Jesper H. Colette, Augistin Francis, Xavier Fraser, Andrea Vivanco, Marta Garcia Jimenez-Guerrero, Pedro Im, Ulas Manders, Astrid Nopmongcol, Uarporn Kitwiroon, Nutthida Pirovano, Guido Pozzoli, Luca Prank, Marje Sokhi, Ranjeet S. Unal, Alper Yarwood, Greg Galmarini, Stefano TI Evaluation and error apportionment of an ensemble of atmospheric chemistry transport modeling systems: multivariable temporal and spatial breakdown SO ATMOSPHERIC CHEMISTRY AND PHYSICS LA English DT Article ID AIR-QUALITY MODEL; SECONDARY ORGANIC AEROSOL; GASEOUS DRY DEPOSITION; BOUNDARY-LAYER; DATA ASSIMILATION; LAND-SURFACE; CMAQ MODEL; CONVECTIVE PARAMETERIZATION; VERTICAL DIFFUSION; FORECASTING SYSTEM AB Through the comparison of several regional-scale chemistry transport modeling systems that simulate meteorology and air quality over the European and North American continents, this study aims at (i) apportioning error to the responsible processes using timescale analysis, (ii) helping to detect causes of model error, and (iii) identifying the processes and temporal scales most urgently requiring dedicated investigations. The analysis is conducted within the framework of the third phase of the Air Quality Model Evaluation International Initiative (AQMEII) and tackles model performance gauging through measurement-to-model comparison, error decomposition, and time series analysis of the models biases for several fields (ozone, CO, SO2, NO, NO2, PM10, PM2.5, wind speed, and temperature). The operational metrics (magnitude sense of model strengths and deficiencies, while apportioning the error to its constituent parts (bias, variance, and covariance) can help assess the nature and quality of the error. Each of the error components is analyzed independently and apportioned to specific processes based on the corresponding timescale (long scale, synoptic, diurnal, and intraday) using the error apportionment technique devised in the former phases of AQMEII. The application of the error apportionment method to the AQMEII Phase 3 simulations provides several key insights. In addition to reaffirming the strong impact of model inputs (emission and boundary conditions) and poor representation of the stable boundary layer on model bias, results also highlighted the high interdependencies among meteorological and chemical variables, as well as among their errors. This indicates that the evaluation of air quality model performance for individual pollutants needs to be supported by complementary analysis of meteorological fields and chemical precursors to provide results that are more insightful from a model development perspective. This will require evaluation methods that are able to frame the impact on error of processes, conditions, and fluxes at the surface. For example, error due to emission and boundary conditions is dominant for primary species (CO, particulate matter (PM)), while errors due to meteorology and chemistry are most relevant to secondary species, such as ozone. Some further aspects emerged whose interpretation requires additional consideration, such as the uniformity of the synoptic error being region-and model-independent, observed for several pollutants; the source of unexplained variance for the diurnal component; and the type of error caused by deposition and at which scale. C1 [Solazzo, Efisio; Pozzoli, Luca; Galmarini, Stefano] European Commiss, Joint Res Ctr, Directorate Energy Transport & Climate, Air & Climate Unit, Ispra, VA, Italy. [Bianconi, Roberto; Bellasio, Roberto] Enviroware Srl, Concorezzo, MB, Italy. [Hogrefe, Christian] US EPA, Computat Exposure Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Curci, Gabriele] Univ Aquila, CETEMPS, Laquila, Italy. [Curci, Gabriele; Tuccella, Paolo] Univ Aquila, Dept Phys & Chem Sci, Laquila, Italy. [Alyuz, Ummugulsum; Pozzoli, Luca; Unal, Alper] Istanbul Tech Univ, Eurasia Inst Earth Sci, Istanbul, Turkey. [Balzarini, Alessandra; Pirovano, Guido] Ric Sistema Energet RSE SpA, Milan, Italy. [Baro, Rocio; Jimenez-Guerrero, Pedro] Univ Murcia, Dept Phys, Phys Earth, Campus Espinardo,Ed CIOyN, E-30100 Murcia, Spain. [Bieser, Johannes] Helmholtz Zentrum Geesthacht, Inst Coastal Res, Chem Transport Modelling Grp, Geesthacht, Germany. [Brandt, Jorgen; Christensen, Jesper H.; Im, Ulas] Aarhus Univ, Dept Environm Sci, Frederiksborgvej 399, DK-4000 Roskilde, Denmark. [Colette, Augistin; Vivanco, Marta Garcia] INERIS, Inst Natl Environm Ind & Risques, Parc Alata, F-60550 Verneuil En Halatte, France. [Francis, Xavier; Sokhi, Ranjeet S.] Univ Hertfordshire, CAIR, Hatfield, Herts, England. [Fraser, Andrea] Ricardo Energy & Environm, Gemini Bldg,Fermi Ave, Harwell OX11 0QR, Oxon, England. [Vivanco, Marta Garcia] CIEMAT, Avda Complutense 40, E-28040 Madrid, Spain. [Manders, Astrid] Netherlands Org Appl Sci Res TNO, Utrecht, Netherlands. [Nopmongcol, Uarporn; Yarwood, Greg] Ramboll Environ, 773 San Marin Dr,Suite 2115, Novato, CA 94998 USA. [Kitwiroon, Nutthida] Kings Coll London, Environm Res Grp, London, England. [Prank, Marje] Finnish Meteorol Inst, Atmospher Composit Res Unit, Helsinki, Finland. RP Solazzo, E (reprint author), European Commiss, Joint Res Ctr, Directorate Energy Transport & Climate, Air & Climate Unit, Ispra, VA, Italy. EM efisio.solazzo@ec.europa.eu NR 173 TC 0 Z9 0 U1 0 U2 0 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1680-7316 EI 1680-7324 J9 ATMOS CHEM PHYS JI Atmos. Chem. Phys. PD FEB 28 PY 2017 VL 17 IS 4 BP 3001 EP 3054 DI 10.5194/acp-17-3001-2017 PG 54 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA EM2LM UT WOS:000395147600002 ER PT J AU He, F Linak, WP Deng, S Li, FX AF He, Feng Linak, William P. Deng, Shuang Li, Fanxing TI Particulate Formation from a Copper Oxide-Based Oxygen Carrier in Chemical Looping Combustion for CO2 Capture SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID IRON-OXIDE; ATTRITION; ENERGY; FUEL; GASIFICATION; PERFORMANCE; CONVERSION; PARTICLES; OXIDATION; BEHAVIOR AB Attrition behavior and particle loss of a copper oxide-based oxygen carrier from a methane chemical looping combustion (CLC) process was investigated in a fluidized bed reactor. The aerodynamic diameters of most elutriated particulates, after passing through a horizontal settling duct, range between 2 and 5 mu m. A notable number of submicrometer particulates are also identified. Oxygen carrier attrition was observed to lead to increased CuO loss resulting from the chemical looping reactions, i.e., Cu is enriched in small particles generated primarily from fragmentation in the size range of 10-75 mu m. Cyclic reduction and oxidation reactions in CLC have been determined to weaken the oxygen carrier particles, resulting in increased particulate emission rates when compared to those of oxygen carriers without redox reactions. The generation rate for particulates <10 mu m was found to decrease with progressive cycles over as-prepared oxygen carrier particles and then reach a steady state. The surface of the oxygen carrier is also found to be coarsened due to a Kirkendall effect, which also explains the enrichment of Cu on particle surfaces and in small particles. C1 [He, Feng; Li, Fanxing] North Carolina State Univ, Dept Chem & Biomol Engn, 911 Partners Way, Raleigh, NC 27695 USA. [Linak, William P.] US EPA, Natl Risk Management Res Lab, 109 TW Alexander Dr, Res Triangle Pk, NC 27709 USA. [Deng, Shuang] Res Acad Environm Sci, State Key Lab Environm Criteria & Risk Assessment, Beijing 100012, Peoples R China. RP Li, FX (reprint author), North Carolina State Univ, Dept Chem & Biomol Engn, 911 Partners Way, Raleigh, NC 27695 USA. EM Fli5@ncsu.edu FU U.S. National Science Foundation [CBET-1510900]; Kenan Institute for Engineering FX Portions of this work were sponsored by the U.S. National Science Foundation (Award CBET-1510900) and the Kenan Institute for Engineering. The authors are grateful to Dean Smith for his assistance on the XRF analysis. The research described in this article has been reviewed by the U.S. EPA National Risk Management Research Laboratory and approved for publication. The contents of this article should not be construed to represent Agency policy nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 41 TC 0 Z9 0 U1 5 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD FEB 21 PY 2017 VL 51 IS 4 BP 2482 EP 2490 DI 10.1021/acs.est.6b04043 PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA EL6ID UT WOS:000394724300066 PM 28075563 ER PT J AU Ran, LM Pleim, J Song, CH Band, L Walker, JT Binkowski, FS AF Ran, Limei Pleim, Jonathan Song, Conghe Band, Larry Walker, John T. Binkowski, Francis S. TI A photosynthesis-based two-leaf canopy stomatal conductance model for meteorology and air quality modeling with WRF/CMAQ PX LSM SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID ATMOSPHERIC BOUNDARY-LAYER; LAND-SURFACE MODEL; LEAF-AREA INDEX; INCLINATION ANGLE DISTRIBUTION; NONLOCAL CLOSURE-MODEL; DOUGLAS-FIR TREES; PART I; DRY DEPOSITION; CARBON-DIOXIDE; TERRESTRIAL BIOSPHERE AB A coupled photosynthesis-stomatal conductance model with single-layer sunlit and shaded leaf canopy scaling is implemented and evaluated in a diagnostic box model with the Pleim-Xiu land surface model (PX LSM) and ozone deposition model components taken directly from the meteorology and air quality modeling system-WRF/CMAQ (Weather Research and Forecast model and Community Multiscale Air Quality model). The photosynthesis-based model for PX LSM (PX PSN) is evaluated at a FLUXNET site for implementation against different parameterizations and the current PX LSM approach with a simple Jarvis function (PX Jarvis). Latent heat flux (LH) from PX PSN is further evaluated at five FLUXNET sites with different vegetation types and landscape characteristics. Simulated ozone deposition and flux from PX PSN are evaluated at one of the sites with ozone flux measurements. Overall, the PX PSN simulates LH as well as the PX Jarvis approach. The PX PSN, however, shows distinct advantages over the PX Jarvis approach for grassland that likely result from its treatment of C-3 and C-4 plants for CO2 assimilation. Simulations using Moderate Resolution Imaging Spectroradiometer (MODIS) leaf area index (LAI) rather than LAI measured at each site assess how the model would perform with grid averaged data used in WRF/CMAQ. MODIS LAI estimates degrade model performance at all sites but one site having exceptionally old and tall trees. Ozone deposition velocity and ozone flux along with LH are simulated especially well by the PX PSN compared to significant overestimation by the PX Jarvis for a grassland site. C1 [Ran, Limei; Pleim, Jonathan; Walker, John T.] US EPA, Res Triangle Pk, NC 27711 USA. [Song, Conghe; Band, Larry] Univ N Carolina, Dept Geog, Chapel Hill, NC USA. [Band, Larry; Binkowski, Francis S.] Univ N Carolina, Inst Environm, Chapel Hill, NC USA. RP Ran, LM (reprint author), US EPA, Res Triangle Pk, NC 27711 USA. EM Ran.Limei@eap.gov NR 98 TC 0 Z9 0 U1 0 U2 0 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X EI 2169-8996 J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD FEB 16 PY 2017 VL 122 IS 3 BP 1930 EP 1952 DI 10.1002/2016JD025583 PG 23 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA EN6MX UT WOS:000396119200033 ER PT J AU Champion, WM Charley, PH Klein, B Stewart, K Solomon, PA Montoya, LD AF Champion, W. M. Charley, P. H. Klein, B. Stewart, K. Solomon, P. A. Montoya, L. D. TI Perception, culture, and science: A framework to identify in-home heating options to improve indoor air quality in the Navajo Nation SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Mixed-method approach; Native Nations; Weatherization; Coal; Wood; Health and environmental benefits ID POLYCYCLIC AROMATIC-HYDROCARBONS; WOOD-BURNING STOVES; PARTICULATE MATTER; PARTICLE EMISSIONS; UNITED-STATES; COMBUSTION; CHILDREN; HEALTH; POLLUTION; COOKING AB A 2010 study identified higher than average incidence of respiratory disease in Shiprock, NM, the largest city in the Navajo Nation. That study suggested that the potential cause was the combustion of solid fuels in in-home heating stoves and that respiratory disease could be greatly reduced by changing indoor heating behaviors and improving heating stove quality. Since the Navajo people are deeply embedded in culture and traditions that strongly influence their daily lives, a new framework was needed to identify feasible heating alternatives that could reduce the negative environmental and health impacts related to solid fuel use while respecting the culture of the Navajo people. The resulting Navajo framework included perception, cultural, and technical assessments to evaluate seven heating alternatives perceived viable by Navajo stakeholders. Cultural experts at the Dine Policy Institute identified potential cultural limitations and motivating factors for each alternative. A limited technical assessment of the health benefits of these options was conducted and integrated into the process. A parallel convergent mixed-methods approach was employed to integrate qualitative and quantitative results. The results and framework developed and presented here may be useful for decision makers in communities heavily reliant on solid fuels for heat, especially Native Nations, where culture plays an important role in the success of any intervention. (C) 2016 Elsevier B.V. All rights reserved. C1 [Champion, W. M.; Montoya, L. D.] Univ Colorado, Civil Environm & Architectural Engn Dept, Sustainabil, Energy & Environm Complex,4001 Discovery Dr, Boulder, CO 80303 USA. [Charley, P. H.; Klein, B.] Dine Environm Inst, Dine Coll Shiprock Campus, POB 580, Shiprock, NM 87420 USA. [Stewart, K.] US EPA, Reg Air Div 9, Air Tox Radiat & Indoor Air Off, 75 Hawthorne St, San Francisco, CA 94105 USA. [Solomon, P. A.] US EPA, Off Res & Dev, 944 E Harmon Ave, Las Vegas, NV 89119 USA. RP Montoya, LD (reprint author), Univ Colorado, Civil Environm & Architectural Engn Dept, Sustainabil, Energy & Environm Complex,4001 Discovery Dr, Boulder, CO 80303 USA. EM Wyatt.Champion@colorado.edu; phcharley@dinecollege.edu; bklein@dinecollege.edu; Stewart.Kathleen@epa.gov; Solomon.Paul@epa.gov; Lupita.Montoya@colorado.edu FU National Science Foundation [0946502]; EPA through its Office of Research and Development FX Data used in the perception assessment were independently funded and independently collected by "in-kind" support of Dine College as a classroom project developed by the class teacher and without involvement from EPA or the University of Colorado. We thank A. Denny, J. McKenzie, and Amber Crotty of the Dine College Policy Institute for their support on the Cultural Assessment and K. Davidson of US EPA for his support on the cost-benefit analysis. We also thank the Dine students and families who participated in the community Perception Assessment. This work was partially supported the National Science Foundation (award 0946502). EPA through its Office of Research and Development partially funded and collaborated in the research described here under assistance agreement by US EPA AE-83528101-0 to Dine College, Shiprock, NM. This manuscript has been subjected to Agency review and approved for publication. Mention of trade names or commercial products does not constitute endorsement, certification, or recommendation for use. NR 55 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD FEB 15 PY 2017 VL 580 BP 297 EP 306 DI 10.1016/j.scitotenv.2016.11.053 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA EM5LS UT WOS:000395353600029 PM 28011023 ER PT J AU He, Y Al-Abed, SR Dionysiou, DD AF He, Yang Al-Abed, Souhail R. Dionysiou, Dionysios D. TI Quantification of carbon nanotubes in different environmental matrices by a microwave induced heating method SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Carbon nanotubes; Quantitative analysis; Microwave method; Quartz sand; Soil; Anaerobic sludge ID BIOLOGICAL SAMPLES; SINGLE; ABSORPTION; NANOMATERIALS; SPECTROSCOPY; ENERGY; RISKS AB Carbon nanotubes (CNTs) have been incorporated into numerous consumer products, and have also been employed in various industrial areas becaUse of their extraordinary properties. The large scale production and wide applications of CNTs make their release into the environment a major concern. Therefore, it is crucial to determine the degree of potential CNT contamination in the environment, which requires a sensitive and accurate technique for selectively detecting and quantifying CNTs in environmental matrices. In this study, a simple device based on utilizing heat generated/temperature increase from CNTs under microwave irradiation was built to quantify single-walled CNTs (SWCNTs), multi-walled CNTs (MWCNTs) and carboxylated CNTs (MWCNT-COOH) in three environmentally relevant matrices (sand, soil and sludge). Linear temperature vs CNT mass relationships were developed for the three environmental matrices spiked with known amounts of different types of CNTs that were then irradiated in a microwave at low energies (70-149 W) for a short time (15-30 s). MWCNTs had a greater microwave response in terms of heat generated/tdmperature increase than SWCNTs and MWCNT-COOH. An evaluation of microwave behavior of different carbonaceous materials shdwed that the microwave measurements of CNTs were not affected even with an excess of other organic, inorganic carbon or carbon based nanomaterials (fullerene, granular activated carbon and graphene oxide), mainly because microwave selectively heats materials such as CNTs that have a higher dielectric loss factor. Quantification limits using this technique for the sand, soil and sludge were determined as low as 18.61, 27.92, 814.4 mu/g for MWCNTs at a microwave power of 133 W and exposure time of 15 s. Published by Elsevier B.V. C1 [He, Yang; Dionysiou, Dionysios D.] Univ Cincinnati, Environm Engn & Sci Program, Dept Biomed Chem & Environm Engn, 2600 Clifton Ave, Cincinnati, OH 45221 USA. [Al-Abed, Souhail R.] US EPA, Natl Risk Management Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. RP Al-Abed, SR (reprint author), US EPA, Natl Risk Management Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM al-abed.souhail@epa.gov FU National Risk Management Research Laboratory of U.S. Environmental Protection Agency (EPA), Cincinnati, Ohio FX This research was funded and conducted by the National Risk Management Research Laboratory of U.S. Environmental Protection Agency (EPA), Cincinnati, Ohio. This manuscript was subjected to EPA internal reviews and quality assurance approval. The research results presented in this paper do not necessarily reflect the views of the Agency or its policy. Mention of trade names or products does not constitute endorsement or recommendation for use. The authors would like to thank Dr. Raghuraman Venkatapathy for valuable comments on the manuscript and Mr. Phillip Cluxton for technical and laboratory support. NR 36 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD FEB 15 PY 2017 VL 580 BP 509 EP 517 DI 10.1016/j.scitotenv.2016.11.205 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA EM5LS UT WOS:000395353600050 PM 28040213 ER PT J AU Hamel, P Falinski, K Sharp, R Auerbach, DA Sanchez-Canales, M Dennedy-Frank, PJ AF Hamel, Perrine Falinski, Kim Sharp, Richard Auerbach, Daniel A. Sanchez-Canales, Maria Dennedy-Frank, P. James TI Sediment delivery modeling in practice: Comparing the effects of watershed characteristics and data resolution across hydroclimatic regions SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE InVEST; Sediment delivery model; Sensitivity analyses; DEM; Uncertainty ID DIGITAL ELEVATION MODELS; ECOSYSTEM SERVICES; FLOW CONNECTIVITY; NORTH-CAROLINA; UNCERTAINTY; LANDSCAPE; YIELD; SOIL; EROSION; SCALES AB Geospatial models are commonly used to quantify sediment contributions at the watershed scale. However, the sensitivity of these models to variation in hydrological and geomorphological features, in particular to land use and topography data, remains uncertain. Here, we assessed the performance of one such model, the InVEST sediment delivery model, for six sites comprising a total of 28 watersheds varying in area (6-13,500 km(2)), climate (tropical, subtropical, mediterranean), topography, and land use/land cover. For each site, we compared uncalibrated and calibrated model predictions with observations and alternative models. We then performed correlation analyses between model outputs and watershed characteristics, followed by sensitivity analyses on the digital elevation model (DEM) resolution. Model performance varied across sites (overall r(2) = 0.47), but estimates of the magnitude of specific sediment export were as or niore accurate than global models. We found significant correlations between metrics of sediment delivery and watershed characteristics, including erosivity, suggesting that empirical relationships may ultimately be developed for ungauged watersheds. Model sensitivity to DEM resolution varied across and within sites, but did not correlate with other observed watershed variables. These results were torroborated by sensitivity analyses performed on synthetic watersheds ranging in mean slope and DEM resolution. Our study provides modelers using InVEST or similar geospatial sediment models with practical insights into model behavior and structural uncertainty: first, comparison of model predictions across regions is possible when environmental conditions differ significantly; second, local knowledge on the sediment budget is needed for calibration; and third, model outputs often show significant sensitivity to DEM resolution. (C) 2016 Elsevier B.V. All rights reserved. C1 [Hamel, Perrine; Sharp, Richard; Dennedy-Frank, P. James] Woods Inst Environm, Nat Capital Project, 371 Serra Mall, Stanford, CA 94305 USA. [Falinski, Kim] Nature Conservancy, Hawaii Marine Program, 923 Nuuanu Ave, Honolulu, HI 96817 USA. [Auerbach, Daniel A.] US EPA, Off Wetlands Oceans & Watersheds, 1301 Constitut Ave, Washington, DC 20460 USA. [Sanchez-Canales, Maria] Univ Politecn Madrid, Escuela Tecn Super Ingenieros Minas & Energia, C Rios Rosas 21, Madrid 28003, Spain. [Dennedy-Frank, P. James] Stanford Univ, Dept Earth Syst Sci, Yang & Yamazaki Y2E2 Bldg 473 Via Ortega, Stanford, CA 94305 USA. RP Hamel, P (reprint author), Woods Inst Environm, Nat Capital Project, 371 Serra Mall, Stanford, CA 94305 USA. EM perrine.hamel@stanford.edu; kim.falinski@tnc.org; richsharp@stanford.edu; auerbach.daniel@epa.gov; mscanales@dmami.upm.es; pjdf@stanford.edu OI Hamel, Perrine/0000-0002-3083-8205 FU Natural Capital Project FX We thank the Natural Capital Project for supporting the postdoctoral research of the first author, and the useful feedback from our colleagues on this work. NR 33 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD FEB 15 PY 2017 VL 580 BP 1381 EP 1388 DI 10.1016/j.scitotenv.2016.12.103 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA EM5LS UT WOS:000395353600135 PM 28040219 ER PT J AU Filer, DL Kothiya, P Setzer, RW Judson, RS Martin, MT AF Filer, Dayne L. Kothiya, Parth Setzer, R. Woodrow Judson, Richard S. Martin, Matthew T. TI tcpl: the ToxCast pipeline for high- throughput screening data SO BIOINFORMATICS LA English DT Article ID PROGRAM AB Motivation: Large high-throughput screening (HTS) efforts are widely used in drug development and chemical toxicity screening. Wide use and integration of these data can benefit from an efficient, transparent and reproducible data pipeline. Summary: The tcpl R package and its associated MySQL database provide a generalized platform for efficiently storing, normalizing and doseresponse modeling of large high-throughput and high-content chemical screening data. The novel dose-response modeling algorithm has been tested against millions of diverse dose-response series, and robustly fits data with outliers and cytotoxicity-related signal loss. C1 [Filer, Dayne L.; Kothiya, Parth; Setzer, R. Woodrow; Judson, Richard S.; Martin, Matthew T.] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA. RP Martin, MT (reprint author), US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA. EM martin.matt@epa.gov NR 10 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1367-4803 EI 1460-2059 J9 BIOINFORMATICS JI Bioinformatics PD FEB 15 PY 2017 VL 33 IS 4 BP 618 EP 620 DI 10.1093/bioinformatics/btw680 PG 3 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Computer Science, Interdisciplinary Applications; Mathematical & Computational Biology; Statistics & Probability SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Computer Science; Mathematical & Computational Biology; Mathematics GA EP3DY UT WOS:000397264100037 PM 27797781 ER PT J AU Koralegedara, NH Al-Abed, SR Arambewela, MKJ Dionysiou, DD AF Koralegedara, N. H. Al-Abed, S. R. Arambewela, M. K. J. Dionysiou, D. D. TI Impact of leaching conditions on constituents release from Flue Gas Desulfurization Gypsum (FGDG) and FGDG-soil mixture SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article; Proceedings Paper CT 4th International Conference on Research Frontiers in Chalcogen Cycle Science and Technology (G16) CY MAY 28-29, 2015 CL UNESCO IHE, Delft, NETHERLANDS HO UNESCO IHE DE Flue Gas Desulfurization Gypsum (FGDG) and FGDG-soil mixture; Element leaching; EPA leaching methods; Selenium; Boron ID BY-PRODUCTS; CHEMICAL-PROPERTIES; TRACE-ELEMENTS; PLANT UPTAKE; FLY-ASH; BORON AB The interest in using Flue Gas Desulfurization Gypsum (FGDG) for land applications has increased recently. This study evaluates the leaching characteristics of trace elements in "modern" FGDG (produced after fly ash removal) and FGDG-mixed soil (SF) under different environmental conditions using recently approved EPA leaching methods (1313-1316). These methods employ various pH and liquid-solid (LS) ratios under batch leaching, column percolation and diffusion controlled release scenarios. Toxicity Characteristic Leaching Protocol (TCLP) and Synthetic Precipitation Leaching Protocol (SPLP) were. used for comparison. The data obtained from new EPA methods provide broad insight into constituent release from FGDG and SF when compared to TCLP and SPLP. The release of toxic elements such as Hg, As, Pb, Co, Cd and Cr from SF was negligible. High release of B from FGDG was observed under all tested conditions; however, its release from SF was low. Both FGDG and SF released Se under all pH conditions (2-13) and LS ratios (1-10) in low concentrations (0.02-0.2 mg/L). The data from this study could be used to investigate potential use of "modern" FGDG for new beneficial land applications. Published by Elsevier B.V. C1 [Koralegedara, N. H.; Arambewela, M. K. J.] Pegasus Tech Serv Inc, 46 E Hollister St, Cincinnati, OH 45219 USA. [Al-Abed, S. R.] US EPA, Natl Risk Management Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. [Koralegedara, N. H.; Dionysiou, D. D.] Univ Cincinnati, Engn Res Ctr 705, DBCEE, Cincinnati, OH 45221 USA. RP Al-Abed, SR (reprint author), US EPA, Natl Risk Management Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM al-abed.souhail@epa.gov NR 46 TC 0 Z9 0 U1 23 U2 23 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 EI 1873-3336 J9 J HAZARD MATER JI J. Hazard. Mater. PD FEB 15 PY 2017 VL 324 SI SI BP 83 EP 93 DI 10.1016/j.jhazmat.2016.01.019 PN A PG 11 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA EG0LI UT WOS:000390723900011 PM 26810504 ER PT J AU Ng, NL Brown, SS Archibald, AT Atlas, E Cohen, RC Crowley, JN Day, DA Donahue, NM Fry, JL Fuchs, H Griffin, RJ Guzman, MI Herrmann, H Hodzic, A Iinuma, Y Jimenez, JL Kiendler-Scharr, A Lee, BH Luecken, DJ Mao, JQ McLaren, R Mutzel, A Osthoff, HD Ouyang, B Picquet-Varrault, B Platt, U Pye, HOT Rudich, Y Schwantes, RH Shiraiwa, M Stutz, J Thornton, JA Tilgner, A Williams, BJ Zaveri, RA AF Ng, Nga Lee Brown, Steven S. Archibald, Alexander T. Atlas, Elliot Cohen, Ronald C. Crowley, John N. Day, Douglas A. Donahue, Neil M. Fry, Juliane L. Fuchs, Hendrik Griffin, Robert J. Guzman, Marcelo I. Herrmann, Hartmut Hodzic, Alma Iinuma, Yoshiteru Jimenez, Jose L. Kiendler-Scharr, Astrid Lee, Ben H. Luecken, Deborah J. Mao, Jingqiu McLaren, Robert Mutzel, Anke Osthoff, Hans D. Ouyang, Bin Picquet-Varrault, Benedicte Platt, Ulrich Pye, Havala O. T. Rudich, Yinon Schwantes, Rebecca H. Shiraiwa, Manabu Stutz, Jochen Thornton, Joel A. Tilgner, Andreas Williams, Brent J. Zaveri, Rahul A. TI Nitrate radicals and biogenic volatile organic compounds: oxidation, mechanisms, and organic aerosol SO ATMOSPHERIC CHEMISTRY AND PHYSICS LA English DT Article ID GAS-PHASE REACTIONS; IONIZATION MASS-SPECTROMETRY; SOUTHEASTERN UNITED-STATES; DIFFERENTIAL OPTICAL-ABSORPTION; IN-SITU DETECTION; RING-DOWN SPECTROSCOPY; CONTINENTAL BOUNDARY-LAYER; METHYL VINYL KETONE; VAPOR WALL LOSS; INDUCED FLUORESCENCE TECHNIQUE AB Oxidation of biogenic volatile organic compounds (BVOC) by the nitrate radical (NO3) represents one of the important interactions between anthropogenic emissions related to combustion and natural emissions from the biosphere. This interaction has been recognized for more than 3 decades, during which time a large body of research has emerged from laboratory, field, and modeling studies. NO3-BVOC reactions influence air quality, climate and visibility through regional and global budgets for reactive nitrogen (particularly organic nitrates), ozone, and organic aerosol. Despite its long history of research and the significance of this topic in atmospheric chemistry, a number of important uncertainties remain. These include an incomplete understanding of the rates, mechanisms, and organic aerosol yields for NO3-BVOC reactions, lack of constraints on the role of heterogeneous oxidative processes associated with the NO3 radical, the difficulty of characterizing the spatial distributions of BVOC and NO3 within the poorly mixed nocturnal atmosphere, and the challenge of constructing appropriate boundary layer schemes and non-photochemical mechanisms for use in state-of-the-art chemical transport and chemistry-climate models. This review is the result of a workshop of the same title held at the Georgia Institute of Technology in June 2015. The first half of the review summarizes the current literature on NO3-BVOC chemistry, with a particular focus on recent advances in instrumentation and models, and in organic nitrate and secondary organic aerosol (SOA) formation chemistry. Building on this current understanding, the second half of the review outlines impacts of NO3-BVOC chemistry on air quality and climate, and suggests critical research needs to better constrain this interaction to improve the predictive capabilities of atmospheric models. C1 [Ng, Nga Lee] Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA. [Ng, Nga Lee] Georgia Inst Technol, Sch Earth & Atmospher Sci, Atlanta, GA 30332 USA. [Brown, Steven S.] NOAA, Div Chem Sci, Earth Syst Res Lab, Boulder, CO USA. [Brown, Steven S.; Day, Douglas A.] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA. [Archibald, Alexander T.; Day, Douglas A.; Jimenez, Jose L.] Univ Cambridge, Natl Ctr Atmospher Sci, Cambridge, England. [Atlas, Elliot] Univ Miami, RSMAS, Dept Atmospher Sci, Miami, FL USA. [Cohen, Ronald C.] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA. [Crowley, John N.] Max Planck Inst Chem, Div Atmospher Chem, Mainz, Germany. [Day, Douglas A.; Jimenez, Jose L.] Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA. [Donahue, Neil M.] Carnegie Mellon Univ, Ctr Atmospher Particle Studies, Pittsburgh, PA 15213 USA. [Fry, Juliane L.] Reed Coll, Dept Chem, Portland, OR USA. [Fuchs, Hendrik; Kiendler-Scharr, Astrid] Forschungszentrum Julich, Inst Energ & Klimaforschung Troposphare IEK 8, Julich, Germany. [Griffin, Robert J.] Rice Univ, Dept Civil & Environm Engn, Houston, TX USA. [Guzman, Marcelo I.] Univ Kentucky, Dept Chem, Lexington, KY 40506 USA. [Herrmann, Hartmut; Iinuma, Yoshiteru; Mutzel, Anke; Tilgner, Andreas] Leibniz Inst Tropospher Res, Atmospher Chem Dept, Leipzig, Germany. [Hodzic, Alma] Natl Ctr Atmospher Res, Atmospher Chem Observat & Modeling, POB 3000, Boulder, CO 80307 USA. [Lee, Ben H.] Univ Washington, Dept Atmospher Sci, Seattle, WA 98195 USA. [Luecken, Deborah J.; Pye, Havala O. T.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Mao, Jingqiu] Princeton Univ, Program Atmospher & Ocean Sci, Princeton, NJ 08544 USA. [Mao, Jingqiu] Natl Ocean & Atmospher Adm, Geophys Fluid Dynam Lab, Princeton, NJ USA. [McLaren, Robert] York Univ, Ctr Atmospher Chem, Toronto, ON, Canada. [Osthoff, Hans D.] Univ Calgary, Dept Chem, Calgary, AB, Canada. [Ouyang, Bin] Univ Cambridge, Dept Chem, Cambridge, England. [Picquet-Varrault, Benedicte] Univ Paris Est Creteil & I Paris Diderot, Inst Pierre Simon Laplace, CNRS, Lab Interuniv Syst Atmospher, Creteil, France. [Platt, Ulrich] Heidelberg Univ, Inst Environm Phys, Heidelberg, Germany. [Rudich, Yinon] Weizmann Inst Sci, Dept Earth & Planetary Sci, Rehovot, Israel. [Schwantes, Rebecca H.] CALTECH, Div Geol & Planetary Sci, Pasadena, CA 91125 USA. [Shiraiwa, Manabu] Univ Calif Irvine, Dept Chem, Irvine, CA 92717 USA. [Stutz, Jochen] Univ Calif Los Angeles, Dept Atmospher & Ocean Sci, Los Angeles, CA USA. [Williams, Brent J.] Washington Univ, Dept Energy Environm & Chem Engn, St Louis, MO USA. [Zaveri, Rahul A.] Pacific Northwest Natl Lab, Atmospher Sci & Global Change Div, Richland, WA 99352 USA. [Mao, Jingqiu] Univ Alaska Fairbanks, Inst Geophys, Fairbanks, AK 99775 USA. [Mao, Jingqiu] Univ Alaska Fairbanks, Dept Chem & Biochem, Fairbanks, AK USA. RP Ng, NL (reprint author), Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA.; Ng, NL (reprint author), Georgia Inst Technol, Sch Earth & Atmospher Sci, Atlanta, GA 30332 USA.; Brown, SS (reprint author), NOAA, Div Chem Sci, Earth Syst Res Lab, Boulder, CO USA.; Brown, SS (reprint author), Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA. EM ng@chbe.gatech.edu; steven.s.brown@noaa.gov RI Mao, Jingqiu/F-2511-2010; Shiraiwa, Manabu/A-6246-2010 OI Mao, Jingqiu/0000-0002-4774-9751; Shiraiwa, Manabu/0000-0003-2532-5373 FU International Global Atmospheric Chemistry project (IGAC); US National Science Foundation (NSF) [AGS-1541331, AGS-1644979]; NSF CAREER [AGS-1555034, CHE-1255290]; US Environmental Protection Agency STAR (Early Career) [RD-83540301]; NOAA Atmospheric Chemistry, Carbon Cycle and Climate program; NERC [NE/M00273X/1]; NSF [AGS-0753200, AGS-1352972, AGS-1360834, EPA 83587701-0, AGS-1240604, AGS 1360745]; NOAA Climate Program Office's AC4 program [NA13OAR4310063 (Colorado)/NA13OAR4310070]; NSERC [RGPIN/183982-2012]; DARK KNIGHT project - DFG [HE 3086/25-1]; French National Agency for Research [ONCEM-ANR-12-BS06-0017-01]; USA-Israel Binational Science Foundation (BSF) [2012013]; Henri Gutwirth Foundation; NOAA Climate Program Office grant [NA13OAR4310071]; NOAA Climate and Global Change Postdoctoral Fellowship; US Department of Energy (DOE) Atmospheric System Research (ASR) program [DE-AC06-76RLO 1830] FX The authors acknowledge support from the International Global Atmospheric Chemistry project (IGAC), the US National Science Foundation (NSF grants AGS-1541331 and AGS-1644979), and Georgia Tech College of Engineering and College of Sciences for support of the workshop on nitrate radicals and biogenic hydrocarbons that led to this review article. N. L. Ng acknowledges support from NSF CAREER AGS-1555034 and US Environmental Protection Agency STAR (Early Career) RD-83540301. S. S. Brown acknowledges support from the NOAA Atmospheric Chemistry, Carbon Cycle and Climate program. A. T. Archibald and B. Ouyang thank NERC for funding through NE/M00273X/1. E. Atlas acknowledges NSF grant AGS-0753200. R. C. Cohen acknowledges NSF grant AGS-1352972. J. N. Crowley acknowledges the Max Planck Society. J. L. Fry, D. A. Day, and J. L. Jimenez acknowledge support from the NOAA Climate Program Office's AC4 program, award no. NA13OAR4310063 (Colorado)/NA13OAR4310070 (Reed). N. M. Donahue acknowledges NSF AGS-1447056. M. I. Guzman wishes to acknowledge support from NSF CAREER award (CHE-1255290). J. L. Jimenez and D. A. Day acknowledge support from NSF AGS-1360834 and EPA 83587701-0. R. McLaren acknowledges NSERC grant RGPIN/183982-2012. H. Herrmann, A. Tilgner, and A. Mutzel acknowledge the DARK KNIGHT project funded by DFG under HE 3086/25-1. B. Picquet-Varrault acknowledges support from the French National Agency for Research (project ONCEM-ANR-12-BS06-0017-01). R. H. Schwantes acknowledges NSF AGS-1240604. Y. Rudich and S. S. Brown acknowledge support from the USA-Israel Binational Science Foundation (BSF) grant no. 2012013. Y. Rudich acknowledges support from the Henri Gutwirth Foundation. J. Mao acknowledges support from the NOAA Climate Program Office grant no. NA13OAR4310071. J. A. Thornton acknowledges support from NSF AGS 1360745. B. H. Lee was supported by the NOAA Climate and Global Change Postdoctoral Fellowship. R. A. Zaveri acknowledges support from the US Department of Energy (DOE) Atmospheric System Research (ASR) program under contract DE-AC06-76RLO 1830 at Pacific Northwest National Laboratory. The US Environmental Protection Agency (EPA), through its Office of Research and Development (ORD), collaborated in the research described herein. It has been subjected to Agency administrative review and approved for publication, but may not necessarily reflect official Agency policy. NR 456 TC 2 Z9 2 U1 0 U2 0 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1680-7316 EI 1680-7324 J9 ATMOS CHEM PHYS JI Atmos. Chem. Phys. PD FEB 13 PY 2017 VL 17 IS 3 BP 2103 EP 2162 DI 10.5194/acp-17-2103-2017 PG 60 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA EM1WC UT WOS:000395106900002 ER PT J AU De Simone, F Artaxo, P Bencardino, M Cinnirella, S Carbone, F D'Amore, F Dommergue, A Xin, XB Gencarelli, CN Hedgecock, IM Landis, MS Sprovieri, F Suzuki, N Wangberg, I Pirrone, N AF De Simone, Francesco Artaxo, Paulo Bencardino, Mariantonia Cinnirella, Sergio Carbone, Francesco D'Amore, Francesco Dommergue, Aurelien Feng, Xin Bin Gencarelli, Christian N. Hedgecock, Ian M. Landis, Matthew S. Sprovieri, Francesca Suzuki, Noriuki Wangberg, Ingvar Pirrone, Nicola TI Particulate-phase mercury emissions from biomass burning and impact on resulting deposition: a modelling assessment SO ATMOSPHERIC CHEMISTRY AND PHYSICS LA English DT Article ID GLOBAL FIRE EMISSIONS; ATMOSPHERIC MERCURY; CLIMATE; SYSTEM; FOREST; RICE; METHYLMERCURY; SPECIATION; TRANSPORT; OXIDATION AB Mercury (Hg) emissions from biomass burning (BB) are an important source of atmospheric Hg and a major factor driving the interannual variation of Hg concentrations in the troposphere. The greatest fraction of Hg from BB is released in the form of elemental Hg (Hg-(g)(0)). However, little is known about the fraction of Hg bound to particulate matter (Hg-P) released from BB, and the factors controlling this fraction are also uncertain. In light of the aims of the Minamata Convention to reduce intentional Hg use and emissions from anthropogenic activities, the relative importance of Hg emissions from BB will have an increasing impact on Hg deposition fluxes. Hg speciation is one of the most important factors determining the redistribution of Hg in the atmosphere and the geographical distribution of Hg deposition. Using the latest version of the Global Fire Emissions Database (GFEDv4.1s) and the global Hg chemistry transport model, ECHMERIT, the impact of Hg speciation in BB emissions, and the factors which influence speciation, on Hg deposition have been investigated for the year 2013. The role of other uncertainties related to physical and chemical atmospheric processes involving Hg and the influence of model parametrisations were also investigated, since their interactions with Hg speciation are complex. The comparison with atmospheric Hg-P concentrations observed at two remote sites, Amsterdam Island (AMD) and Manaus (MAN), in the Amazon showed a significant improvement when considering a fraction of Hg-P from BB. The set of sensitivity runs also showed how the quantity and geographical distribution of Hg-P emitted from BB has a limited impact on a global scale, although the inclusion of increasing fractions Hg-P does limit Hg-(g)(0) availability to the global atmospheric pool. This reduces the fraction of Hg from BB which deposits to the world's oceans from 71 to 62 %. The impact locally is, however, significant on northern boreal and tropical forests, where fires are frequent, uncontrolled and lead to notable Hg inputs to local ecosystems. In the light of ongoing climatic changes this effect could be potentially be exacerbated in the future. C1 [De Simone, Francesco; Bencardino, Mariantonia; Cinnirella, Sergio; Carbone, Francesco; D'Amore, Francesco; Gencarelli, Christian N.; Hedgecock, Ian M.; Sprovieri, Francesca] UNICAL Polifunz, Div Rende, CNR Inst Atmospher Pollut Res, I-87036 Arcavacata Di Rende, Italy. [Artaxo, Paulo] Univ Sao Paulo, Sao Paulo, Brazil. [Dommergue, Aurelien] Univ Grenoble Alpes, CNRS, IRD, IGE, Grenoble, France. [Feng, Xin Bin] Chinese Acad Sci, State Key Lab Environm Geochem, Inste Geochem, Guiyang, Peoples R China. [Landis, Matthew S.] US EPA, Off Res & Dev, Res Triangle Pk, NC USA. [Suzuki, Noriuki] Minist Environm, NIES, Okinawa, Japan. [Wangberg, Ingvar] Swedish Environm Res Inst Ltd, IVL, Gothenburg, Sweden. [Pirrone, Nicola] CNR Inst Atmospher Pollut Res, Area Ric Roma 1,Via Salaria Km 29 300, I-00015 Rome, Italy. RP De Simone, F (reprint author), UNICAL Polifunz, Div Rende, CNR Inst Atmospher Pollut Res, I-87036 Arcavacata Di Rende, Italy. EM f.desimone@iia.cnr.it RI Feng, Xinbin/F-4512-2011 OI Feng, Xinbin/0000-0002-7462-8998 FU EU project GMOS [FP7-265113] FX We are grateful to Sebastian Rast and colleagues at the Max Planck Institute for Meteorology in Hamburg, Germany, for the distribution of their software ECHAM5 and for providing the access to the processed ERA-INTERIM data. We are grateful to Xin Yang for providing the Br / BrO fields from p-Tomcat. The research was performed in the framework of the EU project GMOS (FP7-265113). The authors would also like to thank the referees whose helpful suggestions and comments contributed much to improving the original manuscript. NR 59 TC 0 Z9 0 U1 1 U2 1 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1680-7316 EI 1680-7324 J9 ATMOS CHEM PHYS JI Atmos. Chem. Phys. PD FEB 8 PY 2017 VL 17 IS 3 BP 1881 EP 1899 DI 10.5194/acp-17-1881-2017 PG 19 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA EM2DP UT WOS:000395126900003 ER PT J AU Xiao, Y Ho, KT Burgess, RM Cashman, M AF Xiao, Yao Ho, Kay T. Burgess, Robert M. Cashman, Michaela TI Aggregation, Sedimentation, Dissolution, and Bioavailability of Quantum Dots in Estuarine Systems SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID MUSSEL MYTILUS-GALLOPROVINCIALIS; OXIDATIVE STRESS; ACUTE TOXICITY; CADMIUM; NANOPARTICLES; BIOACCUMULATION; NANOMATERIALS; TEMPERATURE; BIOTRANSFORMATION; NANOCRYSTALS AB To understand their fate and transport in estuarine systems, the aggregation, sedimentation, and dissolution of CdSe quantum dots (QDs) in seawater were investigated. Hydrodynamic size increased from 40 to 60 nm to >1 mm within 1 h in seawater, and the aggregates were highly polydispersed. Their sedimentation rates in seawater were measured to be 4-10 mm/day. Humic acid (HA), further increased their size and polydispersity, and slowed sedimentation. Light increased their dissolution and release of dissolved Cd. The ZnS shell also slowed release of Cd ions. With sufficient light, HA increased the dissolution of QDs, while with low light, HA alone did not change their dissolution. The benthic zone in estuarine systems is the most probable long-term destination of QDs due to aggregation and sedimentation. The bioavailability of was evaluated using the mysid Americamysis bahia. The 7-day LC50s of particulate and dissolved QDs were 290 and 23 mu g (total Cd)/L, respectively. For mysids, the acute toxicity appears to be from Cd ions; however, research on the effects of QDs should be conducted with other organisms where QDs may be lodged in critical tissues such as gills or filtering apparatus and Cd ions may be released and delivered directly to those tissues. C1 [Xiao, Yao] US EPA, Natl Res Council, Atlantic Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA. [Ho, Kay T.; Burgess, Robert M.] US EPA, Atlantic Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA. [Cashman, Michaela] Univ Rhode Isl, Dept Geosci, Kingston, RI 02881 USA. [Xiao, Yao] Country Garden Holding Co Ltd, Ruttonjee Ctr, Suite 1702,17-F,Dina House,11 Duddell St, Central 10, Hong Kong, Peoples R China. RP Ho, KT (reprint author), US EPA, Atlantic Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA. EM ho.kay@epa.gov FU National Research Council Research Associateship Award at US EPA Atlantic Ecology Division FX This research was performed while the author held a National Research Council Research Associateship Award at US EPA Atlantic Ecology Division. We thank Drs. A. Parks, M. Pelletier, and M. Cantwell for experimental assistance and Drs. T. Luxton, W. Boothman, and A. Parks for technical review. This is EPA contribution number AED-016351 of the US Environmental Protection Agency (EPA), Atlantic Ecology Division (AED), and has been technically reviewed by AED; however, it does not necessarily represent the views of the USEPA. No official endorsement of any aforementioned product should be inferred. NR 48 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD FEB 7 PY 2017 VL 51 IS 3 BP 1357 EP 1363 DI 10.1021/acs.est.6b04475 PG 7 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA EK2DU UT WOS:000393738700042 PM 27951641 ER PT J AU Cao, DD Guo, JH Wang, YW Li, ZN Liang, K Corcoran, MB Hosseini, S Bonina, SMC Rockne, KJ Sturchio, NC Giesy, JP Liu, JF Li, A Jiang, GB AF Cao, Dandan Guo, Jiehong Wang, Yawei Li, Zhuona Liang, Kang Corcoran, Margaret B. Hosseini, Soheil Bonina, Solidea M. C. Rockne, Karl J. Sturchio, Neil C. Giesy, John P. Liu, Jingfu Li, An Jiang, Guibin TI Organophosphate Esters in Sediment of the Great Lakes SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID POLYBROMINATED DIPHENYL ETHERS; BROMINATED FLAME RETARDANTS; HERRING GULL EGGS; POLYCHLORINATED-BIPHENYLS; ORGANIC CONTAMINANTS; DAPHNIA-MAGNA; PHASE-OUT; WATER; PLASTICIZERS; TOXICITY AB This is the first study on organophosphate ester (OPEs) flame retardants and plasticizers in the sediment of the Great Lakes. Concentrations of 14 OPEs were measured in three sediment cores and 88 Ponar surface grabs collected from Lakes Ontario, Michigan, and Superior of North America. The sum of these OPEs (Sigma 14OPEs) in Ponar grabs averaged 2.2, 4.7, and 16.6 ng g(-1)dw in Lakes Superior, Michigan, and Ontario, respectively. Multiple linear regression analyses demonstrated statistically significant associations between logarithm concentrations of Sigma 14OPEs as well as selected congeners in surface grab samples and sediment organic carbon content as well as a newly developed urban distance factor. Temporal trends observed in dated sediment cores from Lake Michigan demonstrated that the recent increase in depositional flux to sediment is dominated by chlorinated OPEs, particularly tris(2chloroisopropyl) phosphate (TCPP), which has a doubling time of about 20 years. Downward diffusion within sediment may have caused vertical fractionation of OPEs over time. Two relatively hydrophilic OPEs including TCPP had much higher concentrations in sediment than estimated based on equilibria between water and sediment organic carbon. Approximately a quarter (17 tonnes) of the estimated total OPE burden (63 tonnes) in Lake Michigan resides in sediment, which may act as a secondary source releasing OPEs to the water column for years to come. C1 [Cao, Dandan; Wang, Yawei; Liang, Kang; Liu, Jingfu; Jiang, Guibin] Chinese Acad Sci, Ecoenvironm Sci Res Ctr, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China. [Guo, Jiehong; Li, Zhuona; Li, An] Univ Illinois, Sch Publ Hlth, Chicago, IL 60612 USA. [Hosseini, Soheil; Bonina, Solidea M. C.; Rockne, Karl J.] Univ Illinois, Dept Civil & Mat Engn, Chicago, IL 60607 USA. [Corcoran, Margaret B.; Sturchio, Neil C.] Univ Illinois, Dept Earth & Environm Sci, Chicago, IL 60607 USA. [Giesy, John P.] Univ Saskatchewan, Dept Vet Biomed Sci, Saskatoon, SK S7N 5B3, Canada. [Giesy, John P.] Univ Saskatchewan, Toxicol Ctr, Saskatoon, SK S7N 5B3, Canada. [Wang, Yawei] Univ Chinese Acad Sci, Beijing 100049, Peoples R China. [Bonina, Solidea M. C.] US EPA, Great Lakes Natl Program Off, Reg 5, Chicago, IL USA. [Corcoran, Margaret B.] CSRA LLC, Schaumburg, IL USA. [Sturchio, Neil C.] Univ Delaware, Dept Geol Sci, Newark, DC USA. RP Wang, YW (reprint author), Chinese Acad Sci, Ecoenvironm Sci Res Ctr, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China.; Li, A (reprint author), Univ Illinois, Sch Publ Hlth, Chicago, IL 60612 USA.; Wang, YW (reprint author), Univ Chinese Acad Sci, Beijing 100049, Peoples R China. EM ywwang@rcees.ac.cn; anli@uic.edu RI Liu, Jingfu/M-9391-2013 OI Liu, Jingfu/0000-0001-7134-7026 FU U.S. EPA Great Lakes Restoration Initiative with Assistance [GL-00E00538]; National Natural Science Foundation of China [21625702, 21407157]; National Basic Research Program of China [2015CB453102]; Strategic Priority Research Program of the Chinese Academy of Science [XDB14010400]; Institute for Environmental Science and Policy at the University of Illinois at Chicago (UIC); Canada Research Chair program; High Level Foreign Experts [GDT20143200016]; State Administration of Foreign Experts Affairs; P.R. China to Nanjing University; Einstein Professor Program of the Chinese Academy of Sciences; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong FX This research was part of the Great Lakes Sediment Surveillance Program (GLSSP). This work was supported by a Cooperative Agreement from the U.S. EPA Great Lakes Restoration Initiative with Assistance No. GL-00E00538 (EPA Program Officer Todd Nettesheim), the National Natural Science Foundation of China (21625702, 21407157), the National Basic Research Program of China (2015CB453102), and the Strategic Priority Research Program of the Chinese Academy of Science (XDB14010400). J.G. and S.H. were also supported by the Predoctoral Fellowship provided by the Institute for Environmental Science and Policy at the University of Illinois at Chicago (UIC). Prof. Giesy was supported by the Canada Research Chair program, the 2012 "High Level Foreign Experts" (#GDT20143200016) program, funded by the State Administration of Foreign Experts Affairs, the P.R. China to Nanjing University and the Einstein Professor Program of the Chinese Academy of Sciences and a Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong. We thank the crews of R/V Lake Guardian for assistance during sediment sampling. NR 45 TC 0 Z9 0 U1 19 U2 19 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD FEB 7 PY 2017 VL 51 IS 3 BP 1441 EP 1449 DI 10.1021/acs.est.6b05484 PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA EK2DU UT WOS:000393738700051 PM 28084727 ER PT J AU Gantt, B Sarwar, G Xing, J Simon, H Schwede, D Hutzell, WT Mathur, R Saiz-Lopez, A AF Gantt, Brett Sarwar, Golam Xing, Jia Simon, Heather Schwede, Donna Hutzell, William T. Mathur, Rohit Saiz-Lopez, Alfonso TI The Impact of Iodide-Mediated Ozone Deposition and Halogen Chemistry on Surface Ozone Concentrations Across the Continental United States SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID MARINE BOUNDARY-LAYER; CMAQ MODELING SYSTEM; AIR-QUALITY; NORTHERN-HEMISPHERE; SEA-SURFACE; BACKGROUND OZONE; INORGANIC IODINE; NEW-ENGLAND; EMISSIONS; HOUSTON AB The air quality of many large coastal areas in the United States is affected by the confluence of polluted urban and relatively clean marine airmasses, each with distinct atmospheric chemistry. In this context, the role of iodide-mediated ozone (O-3) deposition over seawater and marine halogen chemistry accounted for in both the lateral boundary conditions and coastal waters surrounding the continental U.S. is examined using the Community Multiscale Air Quality (CMAQ) model. Several nested simulations are conducted in which these halogen processes are implemented separately in the continental U.S. and hemispheric CMAQ domains, the latter providing lateral boundary conditions for the former. Overall, it is the combination of these processes within both the continental U.S. domain and from lateral boundary conditions that lead to the largest reductions in modeled surface O-3 concentrations. Predicted reductions in surface O-3 concentrations occur mainly along the coast where CMAQ typically has large overpredictions. These results suggest that a realistic representation of halogen processes in marine regions can improve model prediction of O-3 concentrations near the coast. C1 [Gantt, Brett; Simon, Heather] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA. [Sarwar, Golam; Xing, Jia; Schwede, Donna; Hutzell, William T.; Mathur, Rohit] US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Saiz-Lopez, Alfonso] CSIC, Dept Atmospher Chem & Climate, Inst Phys Chem Rocasolano, Madrid 28006, Spain. RP Sarwar, G (reprint author), US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. EM sarwar.golam@epa.gov RI Saiz-Lopez, Alfonso/B-3759-2015 OI Saiz-Lopez, Alfonso/0000-0002-0060-1581 NR 63 TC 0 Z9 0 U1 6 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD FEB 7 PY 2017 VL 51 IS 3 BP 1458 EP 1466 DI 10.1021/acs.est.6b03556 PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA EK2DU UT WOS:000393738700053 PM 28051851 ER PT J AU Newton, S McMahen, R Stoeckel, JA Chislock, M Lindstrom, A Strynar, M AF Newton, Seth McMahen, Rebecca Stoeckel, James A. Chislock, Michael Lindstrom, Andrew Strynar, Mark TI Novel Polyfluorinated Compounds Identified Using High Resolution Mass Spectrometry Downstream of Manufacturing Facilities near Decatur, Alabama SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID PERFLUOROALKYL SUBSTANCES; MADRID STATEMENT; WATER; ACIDS; DISCOVERY; ALCOHOLS; SURFACE; SLUDGE; SOILS; CHAIN AB Concern over persistence, bioaccumulation, and toxicity has led to international regulation and phaseouts of certain perfluorinated compounds and little is known about their replacement products. High resolution mass spectrometry was used to investigate the occurrence and identity of replacement fluorinated compounds in surface water and sediment of the Tennessee River near Decatur, Alabama. Analysis of legacy Per-and polyfluoroalkyl substances (PFASs) revealed a marked increase in concentrations downstream of manufacturing facilities, with the most abundant compounds being perfluorooctanesulfonate (PFOS), perfluorobutanesulfonate (PFBS), and perfluorooctanoic acid (PFOA) as high as 220 ng L-1, 160 ng L-1, and 120 ng L-1, respectively. A series of nine polyfluorinated carboxylic acids was discovered, each differing by CF2CH2. These acids are likely products or byproducts of a manufacturing process that uses 1,1-difluoroethene, which is registered to a manufacturing facility in the area. Two other predominant compounds discovered have structures consistent with perfluorobutanesulfonate and perfluoroheptanoic acid but have a single hydrogen substituted for a fluorine someplace in their structure. A polyfluoroalkyl sulfate with differing mixes of hydrogen and fluorine substitution was also observed. N-methyl perfluorobutane sulfonamidoacetic acid (MeFBSAA) was observed at high concentrations and several other perfluorobutane sulfonamido substances were present as well. C1 [Newton, Seth; Lindstrom, Andrew; Strynar, Mark] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [McMahen, Rebecca] Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37831 USA. [Stoeckel, James A.; Chislock, Michael] Auburn Univ, Sch Fisheries Aquaculture & Aquat Sci, Auburn, AL 36849 USA. RP Strynar, M (reprint author), US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. EM strynar.mark@epa.gov NR 39 TC 0 Z9 0 U1 4 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD FEB 7 PY 2017 VL 51 IS 3 BP 1544 EP 1552 DI 10.1021/acs.est.6b05330 PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA EK2DU UT WOS:000393738700062 PM 28084732 ER PT J AU Wolfe, AL Wilkin, RT AF Wolfe, Amy L. Wilkin, Richard T. TI Evidence of Sulfate-Dependent Anaerobic Methane Oxidation within an Area Impacted by Coalbed Methane-Related Gas Migration SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID SULFUR ISOTOPE FRACTIONATION; DRINKING-WATER WELLS; BIOGENIC METHANE; MARINE; REDUCTION; HYDROGEN; CARBON; SEDIMENTS; SHALE; ETHANE AB We evaluated water quality characteristics in the northern Raton Basin of Colorado and documented the response of the Poison Canyon aquifer system several years after upward migration of methane gas occurred from the deeper Vermejo Formation coalbed production zone. Results show persistent secondary water quality impacts related to the biodegradation of methane. We identify four distinct characteristics of groundwater- methane attenuation in the Poison Canyon aquifer: (i) consumption of methane and sulfate and production of sulfide and bicarbonate, (ii) methane loss coupled to production of higher molecular weight (C2+) gaseous hydrocarbons, (iii) patterns of C-13 enrichment and depletion in methane an\d dissolved inorganic carbon, and (iv) a systematic shift in sulfur and oxygen isotope ratios of sulfate, indicative of microbial sulfate reduction. We also show that the biogeochemical response of the aquifer system has not mobilized naturally occurring trace metals, including arsenic, chromium, cobalt, nickel, and lead, likely due to the microbial production of hydrogen sulfide which favors stabilization of metals in aquifer solids. C1 [Wolfe, Amy L.; Wilkin, Richard T.] US EPA, Natl Risk Management Res Lab, Ground Water & Ecosyst Restorat Div, 919 Kerr Res Dr, Ada, OK 74820 USA. [Wolfe, Amy L.] Miami Univ, Dept Geol & Environm Earth Sci, Oxford, OH 45056 USA. RP Wilkin, RT (reprint author), US EPA, Natl Risk Management Res Lab, Ground Water & Ecosyst Restorat Div, 919 Kerr Res Dr, Ada, OK 74820 USA. EM wilkin.rick@epa.gov FU EPA through its Office of Research and Development FX The EPA through its Office of Research and Development funded and conducted this research. The views expressed in this paper are those of the authors and do not necessarily reflect the views or policies of EPA. This article has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. The authors thank three anonymous reviewers for their thoughtful comments. We also thank Ralph Ludwig, Michele Simon, Doug Beak, Susan Mravik, Greg Oberley, Tony Lee, Kristie Hargrove, and Lynda Callaway (EPA) and Ecology and Environment, Inc. for support and reviews of this work. We thank the homeowners who participated in this study, the Colorado Oil and Gas Conservation Commission for providing information and logistical support, and Petroglyph Energy, Inc. for permission to sample their monitoring wells and for assistance with the well sampling. NR 59 TC 0 Z9 0 U1 3 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD FEB 7 PY 2017 VL 51 IS 3 BP 1901 EP 1909 DI 10.1021/acs.est.6b03709 PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA EK2DU UT WOS:000393738700102 PM 28029760 ER PT J AU Duan, XD He, XX Wang, D Mezyk, SP Otto, SC Marfil-Vega, R Mills, MA Dionysiou, DD AF Duan, Xiaodi He, Xuexiang Wang, Dong Mezyk, Stephen P. Otto, Shauna C. Marfil-Vega, Ruth Mills, Marc A. Dionysiou, Dionysios D. TI Decomposition of Iodinated Pharmaceuticals by UV-254 nm-assisted Advanced Oxidation Processes SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article; Proceedings Paper CT 14th International Conference on Environmental Science and Technology (CEST) CY SEP 03-05, 2015 CL Rhodes, GREECE DE Thyroxine; Diatrizoate; UV-254 nm photolysis; Hydrogen peroxide; Persulfate ID AQUEOUS-SOLUTION; CONTRAST-MEDIA; WASTE-WATER; PHOTOCHEMICAL DEGRADATION; HYDROGEN-PEROXIDE; UV-IRRADIATION; PHOTOLYSIS; MECHANISM; KINETICS; REMOVAL AB Iodinated pharmaceuticals, thyroxine (a thyroid hormone) and diatrizoate (an iodinated X-ray contrast medium), are among the most prescribed active pharmaceutical ingredients. Both of them have been reported to potentially disrupt thyroid homeostasis even at very low concentrations. In this study, UV 254 nm-based photolysis and photochemical processes, i.e., UV only, UV/H2O2, and UV/S2O82-, were evaluated for the destruction of these two pharmaceuticals. Approximately 40% of 0.5 mu M thyroxine or diatrizoate was degraded through direct photolysis at UV fluence of 160 mJ cm(-2), probably resulting from the photosensitive cleavage of C-I bonds. While the addition of H2O2 only accelerated the degradation efficiency to a low degree, the destruction rates of both chemicals were significantly enhanced in the UV/S2O82- system, suggesting the potential vulnerability of the iodinated chemicals toward UV/S2O82- treatment. Such efficient destruction also occurred in the presence of radical scavengers when biologically treated wastewater samples were used as reaction matrices. The effects of initial oxidant concentrations,solution pH, as well as the presence of natural organic matter (humic acid or fulvic acid) and alkalinity were also investigated in this study. These results provide insights for the removal of iodinated pharmaceuticals in water and/or wastewater using UV-based photochemical processes. (C) 2016 Elsevier B.V. All rights reserved. C1 [Duan, Xiaodi; He, Xuexiang; Wang, Dong; Dionysiou, Dionysios D.] Univ Cincinnati, Environm Engn & Sci Program, Cincinnati, OH 45221 USA. [Mezyk, Stephen P.; Otto, Shauna C.] Calif State Univ Long Beach, Dept Chem & Biochem, 1250 Bellflower Blvd, Long Beach, CA 90840 USA. [Marfil-Vega, Ruth] Amer Water, Innovat & Environm Stewardship, Belleville, IL 62220 USA. [Mills, Marc A.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. [Dionysiou, Dionysios D.] Univ Cyprus, Dept Civil & Environm Engn, Sch Engn, POB 20537, CY-1678 Nicosia, Cyprus. [Dionysiou, Dionysios D.] Univ Cyprus, Nireas Int Water Res Ctr, Sch Engn, POB 20537, CY-1678 Nicosia, Cyprus. RP Dionysiou, DD (reprint author), Univ Cincinnati, Environm Engn & Sci Program, Cincinnati, OH 45221 USA.; Dionysiou, DD (reprint author), Univ Cyprus, Dept Civil & Environm Engn, Sch Engn, POB 20537, CY-1678 Nicosia, Cyprus.; Dionysiou, DD (reprint author), Univ Cyprus, Nireas Int Water Res Ctr, Sch Engn, POB 20537, CY-1678 Nicosia, Cyprus. EM dionysios.d.dionysiou@uc.edu RI Mills, Marc/C-3449-2017; He, Xuexiang/D-7564-2017 OI Mills, Marc/0000-0002-0169-3086; NR 39 TC 0 Z9 0 U1 23 U2 23 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 EI 1873-3336 J9 J HAZARD MATER JI J. Hazard. Mater. PD FEB 5 PY 2017 VL 323 SI SI BP 489 EP 499 DI 10.1016/j.jhazmat.2016.04.022 PN A PG 11 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA EF7HF UT WOS:000390500000051 PM 27267651 ER PT J AU Burgoon, LD Druwe, IL Painter, K Yost, EE AF Burgoon, Lyle D. Druwe, Ingrid L. Painter, Kyle Yost, Erin E. TI Using In Vitro High-Throughput Screening Data for Predicting Benzo[k] Fluoranthene Human Health Hazards SO RISK ANALYSIS LA English DT Article DE High-throughput screening; human health hazard prioritization values; H3PV; riskassessment; risk screening ID ALPHA AB Today there are more than 80,000 chemicals in commerce and the environment. The potential human health risks are unknown for the vast majority of these chemicals as they lack human health risk assessments, toxicity reference values, and risk screening values. We aim to use computational toxicology and quantitative high-throughput screening (qHTS) technologies to fill these data gaps, and begin to prioritize these chemicals for additional assessment. In this pilot, we demonstrate how we were able to identify that benzo[k] fluoranthene may induce DNA damage and steatosis using qHTS data and two separate adverse outcome pathways (AOPs). We also demonstrate how bootstrap natural spline-based meta-regression can be used to integrate data across multiple assay replicates to generate a concentration-response curve. We used this analysis to calculate an in vitro point of departure of 0.751 mu M and risk-specific in vitro concentrations of 0.29 mu M and 0.28 mu M for 1: 1,000 and 1: 10,000 risk, respectively, for DNA damage. Based on the available evidence, and considering that only a single HSD17B4 assay is available, we have low overall confidence in the steatosis hazard identification. This case study suggests that coupling qHTS assays with AOPs and ontologies will facilitate hazard identification. Combining this with quantitative evidence integration methods, such as bootstrap meta-regression, may allow risk assessors to identify points of departure and risk-specific internal/in vitro concentrations. These results are sufficient to prioritize the chemicals; however, in the longer term we will need to estimate external doses for risk screening purposes, such as through margin of exposure methods. C1 [Burgoon, Lyle D.] US Army Engineer Res & Dev Ctr, Res Triangle Pk, NC 27711 USA. [Druwe, Ingrid L.; Painter, Kyle; Yost, Erin E.] US EPA, Oak Ridge Inst Sci & Educ, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA. RP Burgoon, LD (reprint author), US Army Engineer Res & Dev Ctr, Res Triangle Pk, NC 27711 USA. EM lyle.d.burgoon@usace.army.mil FU U.S. Environmental Protection Agency (EPA) Human Health Risk Assessment Program; U.S. Army Environmental Quality and Installations Rapid Hazard Assessment Focus Area Research Project FX The authors thank Drs. Ila Cote, Michelle Angrish, Reeder Sams, and John Vandenberg for their comments on earlier drafts of this article. This project started when Dr. Burgoon was at the U.S. Environmental Protection Agency's National Center for Environmental Assessment, and completed after Dr. Burgoon began working at the U.S. Army Engineer Research and Development Center. The U.S. Environmental Protection Agency (EPA) Human Health Risk Assessment Program and the U.S. Army Environmental Quality and Installations Rapid Hazard Assessment Focus Area Research Project provided financial support. Drs. Druwe and Yost and Mr. Painter were supported by an appointment to the Internship/Research Participation Program at the Office of Research and Development, U.S. EPA, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and the U.S. EPA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0272-4332 EI 1539-6924 J9 RISK ANAL JI Risk Anal. PD FEB PY 2017 VL 37 IS 2 BP 280 EP 290 DI 10.1111/risa.12613 PG 11 WC Public, Environmental & Occupational Health; Mathematics, Interdisciplinary Applications; Social Sciences, Mathematical Methods SC Public, Environmental & Occupational Health; Mathematics; Mathematical Methods In Social Sciences GA EQ0QQ UT WOS:000397776100010 PM 27088631 ER PT J AU Fuller, CH Carter, DR Hayat, MJ Baldauf, R Hull, RW AF Fuller, Christina H. Carter, David R. Hayat, Matthew J. Baldauf, Richard Hull, Rebecca Watts TI Phenology of a Vegetation Barrier and Resulting Impacts on Near-Highway Particle Number and Black Carbon Concentrations on a School Campus SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH LA English DT Article DE black carbon; particulate matter; vegetation; barrier; highway; near-road; season ID AIR-POLLUTION; PARTICULATE MATTER; URBAN FOREST; QUALITY; REMOVAL; DISEASE; CITIES; TREES AB Traffic-related air pollution is a persistent concern especially in urban areas where populations live in close proximity to roadways. Innovative solutions are needed to minimize human exposure and the installation of vegetative barriers shows potential as a method to reduce near-road concentrations. This study investigates the impact of an existing stand of deciduous and evergreen trees on near-road total particle number (PNC) and black carbon (BC) concentrations across three seasons. Measurements were taken during spring, fall and winter on the campus of a middle school in the Atlanta (GA, USA) area at distances of 10 m and 50 m from a major interstate highway. We identified consistent decreases in BC concentrations, but not for PNC, with increased distance from the highway. In multivariable models, hour of day, downwind conditions, distance to highway, temperature and relative humidity significantly predicted pollutant concentrations. The magnitude of effect of these variables differed by season, however, we were not able to show a definitive impact of the vegetative barrier on near-road concentrations. More detailed studies are necessary to further examine the specific configurations and scenarios that may produce pollutant and exposure reductions. C1 [Fuller, Christina H.] Georgia State Univ, Sch Publ Hlth, Div Environm Hlth, POB 3995, Atlanta, GA 30302 USA. [Carter, David R.; Hayat, Matthew J.] Georgia State Univ, Sch Publ Hlth, Div Epidemiol & Biostat, POB 3995, Atlanta, GA 30302 USA. [Baldauf, Richard] US Environm Protect Agcy, Off Res & Dev, Mail Drop 8101R, Res Triangle Pk, NC 27711 USA. [Hull, Rebecca Watts] Georgia Inst Technol, Sch Hist & Sociol, Atlanta, GA 30332 USA. RP Fuller, CH (reprint author), Georgia State Univ, Sch Publ Hlth, Div Environm Hlth, POB 3995, Atlanta, GA 30302 USA. EM cfuller@gsu.edu; rcar371@gmail.com; mhayat@gsu.edu; Baldauf.Richard@epa.gov; rwattshull@gatech.edu FU Center of Excellence: Environmental Health Disparities Core at Georgia State University [3P20MD004806-02S1]; Kaiser Permanente through the SMART: Schools Managing Asthma and Reducing Triggers grant FX Funding for this work was provided by the Center of Excellence: Environmental Health Disparities Core (3P20MD004806-02S1) at Georgia State University and Kaiser Permanente through the SMART: Schools Managing Asthma and Reducing Triggers grant to American Lung Association in Georgia. The views expressed in this publication are those of the individual authors and do not necessarily reflect the views and policies of the U.S. Environmental Protection Agency (EPA). Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 31 TC 0 Z9 0 U1 0 U2 0 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 1660-4601 J9 INT J ENV RES PUB HE JI Int. J. Environ. Res. Public Health PD FEB PY 2017 VL 14 IS 2 AR 160 DI 10.3390/ijerph14020160 PG 13 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA EM7CA UT WOS:000395467900052 ER PT J AU Hall, NL Dvonch, JT Marsik, FJ Barres, JA Landis, MS AF Hall, Naima L. Dvonch, Joseph Timothy Marsik, Frank J. Barres, James A. Landis, Matthew S. TI An Artificial Turf-Based Surrogate Surface Collector for the Direct Measurement of Atmospheric Mercury Dry Deposition SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH LA English DT Article DE mercury; dry deposition; surrogate surface; turf ID REACTIVE GASEOUS MERCURY; GREAT-LAKES REGION; WET DEPOSITION; SPATIAL VARIABILITY; EASTERN OHIO; MASS-BALANCE; VAPOR FLUXES; FOREST; PRECIPITATION; FLORIDA AB This paper describes the development of a new artificial turf surrogate surface (ATSS) sampler for use in the measurement of mercury (Hg) dry deposition. In contrast to many existing surrogate surface designs, the ATSS utilizes a three-dimensional deposition surface that may more closely mimic the physical structure of many natural surfaces than traditional flat surrogate surface designs (water, filter, greased Mylar film). The ATSS has been designed to overcome several complicating factors that can impact the integrity of samples with other direct measurement approaches by providing a passive system which can be deployed for both short and extended periods of time (days to weeks), and is not contaminated by precipitation and/or invalidated by strong winds. Performance characteristics including collocated precision, in-field procedural and laboratory blanks were evaluated. The results of these performance evaluations included a mean collocated precision of 9%, low blanks (0.8 ng), high extraction efficiency (97%-103%), and a quantitative matrix spike recovery (100%). C1 [Hall, Naima L.; Dvonch, Joseph Timothy; Marsik, Frank J.; Barres, James A.] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Air Qual Lab, Ann Arbor, MI 48109 USA. [Landis, Matthew S.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27709 USA. RP Landis, MS (reprint author), US EPA, Off Res & Dev, Res Triangle Pk, NC 27709 USA. EM hallnai@umich.edu; dvonch@umich.edu; marsik@umich.edu; jbarres@umich.edu; landis.matthew@epa.gov FU U.S. Environmental Protection Agency (EPA) through its Office of Research and Development [CR-83302001-0]; Florida Department of Environmental Protection (FLDEP); University of Michigan Air Quality Laboratory (UMAQL) [AQ198] FX The U.S. Environmental Protection Agency (EPA) through its Office of Research and Development funded and participated in the research described here under an EPA Region 4 Regional Applied Research Effort (RARE) through cooperative agreement CR-83302001-0 with the Florida Department of Environmental Protection (FLDEP). The views expressed in this paper are those of the authors and do not necessarily reflect the views or policies of EPA. It has been subjected to EPA Agency review and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. FLDEP administered the project through contract AQ198 with the University of Michigan Air Quality Laboratory (UMAQL). The authors would like to thank Thomas Atkeson and Robert K. Stevens from FLDEP and the students and staff from UMAQL for their dedicated support of this work. The authors especially acknowledge the wisdom and guidance provided by the late Gerald J. Keeler. While Jerry passed prior to the completion of this work, he contributed immensely to its design and implementation. NR 60 TC 0 Z9 0 U1 0 U2 0 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 1660-4601 J9 INT J ENV RES PUB HE JI Int. J. Environ. Res. Public Health PD FEB PY 2017 VL 14 IS 2 AR 173 DI 10.3390/ijerph14020173 PG 13 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA EM7CA UT WOS:000395467900065 ER PT J AU Ober, GT Thornber, C Grear, J Kolbe, JJ AF Ober, Gordon T. Thornber, Carol Grear, Jason Kolbe, Jason J. TI Ecological differences influence the thermal sensitivity of swimming performance in two co-occurring mysid shrimp species with climate change implications SO JOURNAL OF THERMAL BIOLOGY LA English DT Article DE Thermal tolerance; Thermal sensitivity of performance; Climate change; Thermal variation; Ocean warming ID NEOMYSIS-AMERICANA SMITH; VERTICAL MIGRATION; NARRAGANSETT BAY; TOLERANCE; TEMPERATURE; PHYSIOLOGY; EVOLUTION; ADAPTATION; PREDATOR; IMPACTS AB Temperature strongly affects performance in ectotherms. As ocean warming continues, performance of marine species will be impacted. Many studies have focused on how warming will impact physiology, life history, and behavior, but few studies have investigated how ecological and behavioral traits of organisms will affect their response to changing thermal environments. Here, we assessed the thermal tolerances and thermal sensitivity of swimming performance of two sympatric mysid shrimp species of the Northwest Atlantic. Neomysis americana and Heteromysis formosa overlap in habitat and many aspects of their ecological niche, but only N. americana exhibits vertical migration. In temperate coastal ecosystems, temperature stratification of the water column exposes vertical migrators to a wider range of temperatures on a daily basis. We found that N. americana had a significantly lower critical thermal minimum (CTmin) and critical thermal maximum (CTmax). However, both mysid species had a buffer of at least 4 degrees C between their CTmax and the 100-year projection for mean summer water temperatures of 28 degrees C. Swimming performance of the vertically migrating species was more sensitive to temperature variation, and this species exhibited faster burst swimming speeds. The generalist performance curve of H. formosa and specialist curve of N. americana are consistent with predictions based on the exposure of each species to temperature variation such that higher within-generation variability promotes specialization. However, these species violate the assumption of the specialist-generalist tradeoff in that the area under their performance curves is not constant. Our results highlight the importance of incorporating species specific responses to temperature based on the ecology and behavior of organisms into climate change prediction models. C1 [Ober, Gordon T.; Thornber, Carol; Kolbe, Jason J.] Univ Rhode Isl, Dept Biol Sci, Kingston, RI 02881 USA. [Grear, Jason] US EPA, Atlantic Ecol Div, Narragansett, RI 02882 USA. RP Ober, GT (reprint author), Univ Rhode Isl, Dept Biol Sci, Kingston, RI 02881 USA. EM Gordon_ober@uri.edu FU U.S. Environmental Protection Agency's Science to Achieve Results (STAR) program fellowship [FP917627]; National Science Foundation EPSCoR Cooperative Agreement [EPS-1004057]; Rhode Island Science and Technology Advisory Council; EPA FX We thank Nathan Andrews, Kelli Butler, Andrew Fiorenzano, Fiona MacKechnie, and Ushuaia Milstead for their work in the field capturing mysid shrimp and their work recording and analyzing mysid videos. This research has been supported by a grant from the U.S. Environmental Protection Agency's Science to Achieve Results (STAR) program fellowship number FP917627. This material is based upon work supported in part by the National Science Foundation EPSCoR Cooperative Agreement #EPS-1004057. This work was funded by a Rhode Island Science and Technology Advisory Council grant to J. Kolbe and C. Thornber. Although the research described in this article was funded in part by EPA, it has not been subjected to agency review and does not necessarily reflect the views of the agency. We thank two anonymous reviewers for their feedback and insights that have significantly improved this study. NR 100 TC 0 Z9 0 U1 3 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0306-4565 J9 J THERM BIOL JI J. Therm. Biol. PD FEB PY 2017 VL 64 BP 26 EP 34 DI 10.1016/jjtherbio.2016.11.012 PG 9 WC Biology; Zoology SC Life Sciences & Biomedicine - Other Topics; Zoology GA EK6WL UT WOS:000394066600004 PM 28166942 ER PT J AU Davalos, AD Luben, TJ Herring, AH Sacks, JD AF Davalos, Angel D. Luben, Thomas J. Herring, Amy H. Sacks, Jason D. TI Current approaches used in epidemiologic studies to examine short-term multipollutant air pollution exposures SO ANNALS OF EPIDEMIOLOGY LA English DT Review DE Air pollution health effects; Joint effects; Multipollutant; Dimension reduction; Nonparametric methods; Interactions; Differential effects ID PM SOURCE APPORTIONMENT; REGRESSION TREES; DAILY MORTALITY; VARIABLE SELECTION; KERNEL MACHINES; MEXICO-CITY; HEALTH; POLLUTANTS; MODELS; ASSOCIATIONS AB Purpose: Air pollution epidemiology traditionally focuses on the relationship between individual air pollutants and health outcomes (e.g., mortality). To account for potential copollutant confounding, individual pollutant associations are often estimated by adjusting or controlling for other pollutants in the mixture. Recently, the need to characterize the relationship between health outcomes and the larger multipollutant mixture has been emphasized in an attempt to better protect public health and inform more sustainable air quality management decisions. Methods: New and innovative statistical methods to examine multipollutant exposures were identified through a broad literature search, with a specific focus on those statistical approaches currently used in epidemiologic studies of short-term exposures to criteria air pollutants (i.e., particulate matter, carbon monoxide, sulfur dioxide, nitrogen dioxide, and ozone). Results: Five broad classes of statistical approaches were identified for examining associations between short-term multipollutant exposures and health outcomes, specifically additive main effects, effect measure modification, unsupervised dimension reduction, supervised dimension reduction, and nonparametric methods. These approaches are characterized including advantages and limitations in different epidemiologic scenarios. Discussion: By highlighting the characteristics of various studies in which multipollutant statistical methods have been used, this review provides epidemiologists and biostatisticians with a resource to aid in the selection of the most optimal statistical method to use when examining multipollutant exposures. Published by Elsevier Inc. C1 [Davalos, Angel D.; Herring, Amy H.] Univ N Carolina, Dept Biostat, Chapel Hill, NC USA. [Luben, Thomas J.; Sacks, Jason D.] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Mailcode B-243-01, Res Triangle Pk, NC 27711 USA. RP Sacks, JD (reprint author), US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Mailcode B-243-01, Res Triangle Pk, NC 27711 USA. EM sacks.jason@epa.gov FU National Institute of Environmental Health Sciences [R01 ES020619, T32 ES007018] FX The authors would like to acknowledge Danielle Moore for her help in developing the terms used in the broad literature search, and Ellen Kirrane and Ana Rappold for comments on early drafts of the article. This work was supported by the National Institute of Environmental Health Sciences (R01 ES020619, T32 ES007018). NR 54 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1047-2797 EI 1873-2585 J9 ANN EPIDEMIOL JI Ann. Epidemiol. PD FEB PY 2017 VL 27 IS 2 BP 145 EP 153 DI 10.1016/j.annepidem.2016.11.016 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA EL6KF UT WOS:000394730500012 PM 28040377 ER PT J AU Wetendorf, M Wu, SP Wang, XQ Creighton, CJ Wang, TY Lanz, RB Blok, L Tsai, SY Tsai, MJ Lydon, JP DeMayo, FJ AF Wetendorf, Margeaux Wu, San-Pin Wang, Xiaoqiu Creighton, Chad J. Wang, Tianyuan Lanz, Rainer B. Blok, Leen Tsai, Sophia Y. Tsai, Ming-Jer Lydon, John P. DeMayo, Francesco J. TI Decreased epithelial progesterone receptor A at the window of receptivity is required for preparation of the endometrium for embryo attachment SO BIOLOGY OF REPRODUCTION LA English DT Article DE progesterone receptor; implantation; uterine receptivity; progesterone signaling; mouse models ID LEUKEMIA INHIBITORY FACTOR; BLASTOCYST IMPLANTATION; EARLY-PREGNANCY; MAMMARY-GLAND; ESTROUS-CYCLE; MICE LACKING; B ISOFORM; EXPRESSION; MOUSE; UTERUS AB The precise timing of progesterone signaling through its cognate receptor, the progesterone receptor (PGR), is critical for the establishment and maintenance of pregnancy. Loss of PGR expression in the murine uterine epithelium during the preimplantation period is a marker for uterine receptivity and embryo attachment. We hypothesized that the decrease in progesterone receptor A (PGRA) expression is necessary for successful embryo implantation. To test this hypothesis, a mouse model constitutively expressing PGRA (mPgrA(LsL/+)) was generated. Expression of PGRA in all uterine compartments (Pgrcre) or uterine epithelium (Wnt7a(cre)) resulted in infertility with defects in embryo attachment and stromal decidualization. Expression of critical PGRA target genes, in-dian hedgehog, and amphiregulin (Areg), wasmaintained through the window of receptivity while the estrogen receptor target gene, the leukemia inhibitory factor (Lif), a key regulator of embryo receptivity, was decreased. Transcriptomic and cistromic analyses of the mouse uterus at day 4.5 of pregnancy identified an altered group of genes regulating molecular transport in the control of fluid and ion levels within the uterine interstitial space. Additionally, LIF and its cognate receptor, the leukemia inhibitory factor receptor (LIFR), exhibited PGR-binding events in regions upstream of the transcriptional start sites, suggesting PGRA is inhibiting transcription at these loci. Therefore, downregulation of the PGRA isoform at the window of receptivity is necessary for the attenuation of hedgehog signaling, transcriptional activation of LIF signaling, and modulation of solutes and fluid, producing a receptive environment for the attaching embryo. Summary Sentence Expression of PGRA at the window of receptivity transcriptionally represses LIF signaling and aberrantly regulates hedgehog and solute signaling rendering the uterus unreceptive to the implanting embryo. C1 [Wetendorf, Margeaux; Wu, San-Pin; Wang, Xiaoqiu; DeMayo, Francesco J.] Natl Inst Environm Hlth Sci, Reprod & Dev Biol Lab, 111 TW Alexander Dr,Res Triangle Pk, Durham, NC 27709 USA. [Wetendorf, Margeaux; Lanz, Rainer B.; Tsai, Sophia Y.; Tsai, Ming-Jer; Lydon, John P.] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA. [Wetendorf, Margeaux] Baylor Coll Med, Integrat Mol & Biomed Sci Grad Program, Houston, TX 77030 USA. [Creighton, Chad J.] Baylor Coll Med, Dan L Duncan Comprehens Canc Ctr, Houston, TX 77030 USA. [Wang, Tianyuan] Natl Inst Environm Hlth Sci, Integrat Bioinformat, Res Triangle Pk, Durham, NC USA. [Blok, Leen] Univ Med Ctr Rotterdam, Erasmus MC Canc Inst, Dept Obstet & Gynaecol, Rotterdam, Netherlands. RP DeMayo, FJ (reprint author), Natl Inst Environm Hlth Sci, Reprod & Dev Biol Lab, 111 TW Alexander Dr,Res Triangle Pk, Durham, NC 27709 USA. EM demayofj@niehs.nih.gov FU NIH [Z1AES103311-01, R01HD042311, R01CA77530, P30CA125123]; NURSA [U19DK62434] FX This work was supported by NIH Grants: Z1AES103311-01, R01HD042311, R01CA77530 (to John P. Lydon), P30CA125123 (to Chad J. Creighton), and NURSA grant: U19DK62434 (to Ming-Jer Tsai, Sophia Y. Tsai, and Francesco J. DeMayo). NR 36 TC 0 Z9 0 U1 0 U2 0 PU SOC STUDY REPRODUCTION PI MADISON PA 1691 MONROE ST,SUITE # 3, MADISON, WI 53711-2021 USA SN 0006-3363 EI 1529-7268 J9 BIOL REPROD JI Biol. Reprod. PD FEB PY 2017 VL 96 IS 2 BP 313 EP 326 DI 10.1095/biolreprod.116.144410 PG 14 WC Reproductive Biology SC Reproductive Biology GA EP3UW UT WOS:000397308200005 PM 28203817 ER PT J AU Langley, GR Adcock, IM Busquet, F Crofton, KM Csernok, E Giese, C Heinonen, T Herrmann, K Hofmann-Apitius, M Landesmann, B Marshall, LJ McIvor, E Muotri, AR Noor, F Schutte, K Seidle, T van de Stolpe, A Van Esch, H Willett, C Woszczek, G AF Langley, Gillian R. Adcock, Ian M. Busquet, Francois Crofton, Kevin M. Csernok, Elena Giese, Christoph Heinonen, Tuula Herrmann, Kathrin Hofmann-Apitius, Martin Landesmann, Brigitte Marshall, Lindsay J. McIvor, Emily Muotri, Alysson R. Noor, Fozia Schutte, Katrin Seidle, Troy van de Stolpe, Anja Van Esch, Hilde Willett, Catherine Woszczek, Grzegorz TI Towards a 21st-century roadmap for biomedical research and drug discovery: consensus report and recommendations SO DRUG DISCOVERY TODAY LA English DT Review ID PLURIPOTENT STEM-CELLS; ALZHEIMERS-DISEASE RESEARCH; IN-VITRO MODEL; HEPARG CELLS; ANIMAL-MODELS; ASTHMA; TOXICITY; OPPORTUNITIES; HEPATOCYTES; MECHANISMS AB Decades of costly failures in translating drug candidates from preclinical disease models to human therapeutic use warrant reconsideration of the priority placed on animal models in biomedical research. Following an international workshop attended by experts from academia, government institutions, research funding bodies, and the corporate and non -governmental organisation (NGO) sectors, in this consensus report, we analyse, as case studies, five disease areas with major unmet needs for new treatments. In view of the scientifically driven transition towards a human pathways-based paradigm in toxicology, a similar paradigm shift appears to be justified in biomedical research. There is a pressing need for an approach that strategically implements advanced, human biology-based models and tools to understand disease pathways at multiple biological scales. We present recommendations to help achieve this. C1 [Langley, Gillian R.] Humane Soc Int, Res & Toxicol Dept, London, England. [Adcock, Ian M.] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Resp Cell & Mol Biol, London, England. [Busquet, Francois] Ctr Alternat Anim Testing CAAT Europe, Brussels, Belgium. [Crofton, Kevin M.] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC USA. [Csernok, Elena] Univ Tubingen, Acad Teaching Hosp, Kirchheim Clin, Esslingen Dist Clin GmbH,Dept Internal Med Rheuma, Kirchheim Unter Teck, Germany. [Giese, Christoph] ProBioGen AG, Berlin, Germany. [Heinonen, Tuula] Univ Tampere, Sch Med, Finnish Ctr Alternat Methods, Tampere, Finland. [Herrmann, Kathrin] Free Univ Berlin, Dahlem Res Sch, Berlin, Germany. [Hofmann-Apitius, Martin] Inst Zentrum Birlinghoven, Fraunhofer Inst Algorithms & Sci Comp SCAI, Dept Bioinformat, St Augustin, Germany. [Landesmann, Brigitte] F3 Chem Safety & Alternat Methods Unit, Directorate F Hlth Consumers & Reference Mat, DG Joint Res Ctr, European Commiss, Ispra, Italy. [Marshall, Lindsay J.] Aston Univ, Sch Life & Hlth Sci, Birmingham, W Midlands, England. [McIvor, Emily] Humane Soc Int, London, England. [Muotri, Alysson R.] Sanford Consortium, Rady Childrens Hosp, UCSD Sch Med, Dept Pediat & Cellular & Mol Med, La Jolla, CA USA. [Noor, Fozia] Univ Saarland, Biochem Engn Inst, Saarbrucken, Germany. [Schutte, Katrin] European Commiss, DG Environm, Directorate A Green Econ, Unit Chem A3, Brussels, Belgium. [Seidle, Troy] Humane Soc Int, Res & Toxicol Dept, Toronto, ON, Canada. [van de Stolpe, Anja] Philips Grp Innovat, Philips Res, Eindhoven, Netherlands. [Van Esch, Hilde] Univ Hosp Leuven, Ctr Human Genet, Leuven, Belgium. [Willett, Catherine] Humane Soc United States, Anim Res Issues, Boston, MA USA. [Woszczek, Grzegorz] Kings Coll London, Guys Hosp, Div Asthma Allergy & Lung Biol, MRC Asthma UK Ctr Allerg Mech Asthma, London, England. RP Langley, GR (reprint author), Humane Soc Int, Res & Toxicol Dept, London, England. EM sciencesources@btinternet.com FU World Animal Protection; European Community's Seventh Framework Programme (FP7) [267038]; Cosmetics Europe; NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton NHS Foundation Trust; Imperial College London FX The Brussels BioMed21 Workshop was led by Humane Society International and supported with funding from World Animal Protection. The funding source had no involvement in the writing of the report. The EU-NOTOX project is funded within the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement number 267038 and Cosmetics Europe. Research by I.M.A. is supported by the NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton NHS Foundation Trust and Imperial College London. We thank James Adjaye, Anthony Bailey, Kate Garrod, Stuart Pritchard, and Renate Weissenhorn for contributions to the Workshop and Susan Mayor for assistance with drafting this paper. NR 65 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-6446 EI 1878-5832 J9 DRUG DISCOV TODAY JI Drug Discov. Today PD FEB PY 2017 VL 22 IS 2 BP 327 EP 339 DI 10.1016/j.drudis.2016.10.011 PG 13 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA EM3OF UT WOS:000395223800012 PM 27989722 ER PT J AU Leigh, C Laporte, B Bonada, N Fritz, K Pella, H Sauquet, E Tockner, K Datry, T AF Leigh, Catherine Laporte, Baptiste Bonada, Nuria Fritz, Ken Pella, Herve Sauquet, Eric Tockner, Klement Datry, Thibault TI IRBAS: An online database to collate, analyze, and synthesize data on the biodiversity and ecology of intermittent rivers worldwide SO ECOLOGY AND EVOLUTION LA English DT Article DE aquatic and terrestrial biodiversity; data sharing; global change; meta-analysis; temporary river; water management ID TEMPORARY RIVERS; INVERTEBRATES; PERSPECTIVES; CHALLENGES AB Key questions dominating contemporary ecological research and management concern interactions between biodiversity, ecosystem processes, and ecosystem services provision in the face of global change. This is particularly salient for freshwater biodiversity and in the context of river drying and flow-regime change. Rivers that stop flowing and dry, herein intermittent rivers, are globally prevalent and dynamic ecosystems on which the body of research is expanding rapidly, consistent with the era of big data. However, the data encapsulated by this work remain largely fragmented, limiting our ability to answer the key questions beyond a case-by-case basis. To this end, the Intermittent River Biodiversity Analysis and Synthesis (IRBAS; http://irbas.cesab.org) project has collated, analyzed, and synthesized data from across the world on the biodiversity and environmental characteristics of intermittent rivers. The IRBAS database integrates and provides free access to these data, contributing to the growing, and global, knowledge base on these ubiquitous and important river systems, for both theoretical and applied advancement. The IRBAS database currently houses over 2000 data samples collected from six countries across three continents, primarily describing aquatic invertebrate taxa inhabiting intermittent rivers during flowing hydrological phases. As such, there is room to expand the biogeographic and taxonomic coverage, for example, through addition of data collected during nonflowing and dry hydrological phases. We encourage contributions and provide guidance on how to contribute and access data. Ultimately, the IRBAS database serves as a portal, storage, standardization, and discovery tool, enabling collation, synthesis, and analysis of data to elucidate patterns in river biodiversity and guide management. Contribution creates high visibility for datasets, facilitating collaboration. The IRBAS database will grow in content as the study of intermittent rivers continues and data retrieval will allow for networking, meta-analyses, and testing of generalizations across multiple systems, regions, and taxa. C1 [Leigh, Catherine; Pella, Herve; Datry, Thibault] Ctr Lyon Villeurbanne, Irstea, UR MALY, Villeurbanne, France. [Leigh, Catherine; Laporte, Baptiste] CESAB FRB, Aix En Provence 3, France. [Leigh, Catherine] Griffith Univ, Australian Rivers Inst, Nathan, Qld, Australia. [Leigh, Catherine] Griffith Univ, Griffith Sch Environm, Nathan, Qld, Australia. [Bonada, Nuria] Univ Barcelona, Grp Recerca Freshwater Ecol & Management FEM, Dept Ecol, Inst Recerca Biodivers IRBio, Barcelona, Catalonia, Spain. [Fritz, Ken] US EPA, Off Res & Dev, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. [Sauquet, Eric] Ctr Lyon Villeurbanne, UR HHLY, Irstea, Villeurbanne, France. [Tockner, Klement] Free Univ Berlin, Leibniz Inst Freshwater Ecol & Inland Fisheries, Inst Biol, IGB, Berlin, Germany. [Tockner, Klement] Free Univ Berlin, FU, Inst Biol, Berlin, Germany. RP Leigh, C (reprint author), Griffith Univ, Australian Rivers Inst, Nathan, Qld, Australia.; Leigh, C (reprint author), Griffith Univ, Griffith Sch Environm, Nathan, Qld, Australia. EM c.leigh@griffith.edu.au OI Leigh, Catherine/0000-0003-4186-1678 FU IRBAS; Centre for Synthesis and Analysis of Biodiversity (CESAB); French Foundation for Research & Biodiversity (FRB); French National Agency for Water and Aquatic Environments (ONEMA) FX IRBAS; Centre for Synthesis and Analysis of Biodiversity (CESAB); French Foundation for Research & Biodiversity (FRB); French National Agency for Water and Aquatic Environments (ONEMA). NR 18 TC 0 Z9 0 U1 2 U2 2 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2045-7758 J9 ECOL EVOL JI Ecol. Evol. PD FEB PY 2017 VL 7 IS 3 BP 815 EP 823 DI 10.1002/ece3.2679 PG 9 WC Ecology; Evolutionary Biology SC Environmental Sciences & Ecology; Evolutionary Biology GA EL3FD UT WOS:000394504100003 PM 28168018 ER PT J AU Farcas, D Harper, M Januch, JW Jacobs, TA Sarkisian, K Stetler, LD Schwegler-Berry, D AF Farcas, Daniel Harper, Martin Januch, Jed W. Jacobs, Teri A. Sarkisian, Khachatur Stetler, Larry D. Schwegler-Berry, Diane TI Evaluation of fluidized bed asbestos segregator to determine erionite in soil SO ENVIRONMENTAL EARTH SCIENCES LA English DT Article DE Erionite; Soil analysis; South Dakota; Fluidized bed asbestos segregator; FBAS; Microscopy ID UNITED-STATES; NORTH-DAKOTA AB Three sets of soil samples were collected by the National Institute for Occupational Safety and Health and one set by South Dakota School of Mines & Technology from in and around the Slim Buttes Land Unit of the Sioux Ranger District of the Custer-Gallatin National Forest in the northwest of South Dakota. The rocks forming the Slim Buttes are sedimentary clays, sands and gravels including re-worked volcanic ash-falls in which the zeolite mineral erionite has crystallized during diagenesis in a fibrous form or morphology similar to that of asbestos. The samples were prepared using the fluidized bed asbestos segregator (FBAS) and analyzed by phase contrast microscopy (PCM) or transmission electron microscopy to detect the presence of mineral fibers. FBAS-PCM results compared to semi-quantitative polarized light microscopy (PLM) and X-ray diffraction analysis indicated a recovery of approximately 1% and a linear relationship that likely can be extrapolated to concentrations well below the 1% detection limit of PLM. There were small variations between a PCM count of 10 fibers to a count of 100 fibers (or a maximum of 200 microscopic fields of view), which indicates the possibility of rapid turnaround of results. Although the four sets of samples examined in this work were collected by slightly different techniques, some tentative conclusions can be drawn about the distribution of erionite in soils. Erionite was detected in almost every soil sample, even those taken several miles from the outcrop, but without any distribution indicating recent transportation from the current volcaniclastic sediment outcrops. Removal of more extensive volcaniclastic sediments through erosion may have resulted in remnant material in soils, including erionite crystals, but this possibility requires further study. Although we have demonstrated that erionite in soils can be detected through FBAS-PCM, we have not attempted to correlate those results with human inhalation exposure through activity-based sampling, and thus, any risk inherent in working these soils is unknown. C1 [Farcas, Daniel; Harper, Martin] NIOSH, Exposure Assessment Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, 1095 Willowdale Rd M-S 3030, Morgantown, WV 26505 USA. [Farcas, Daniel] West Virginia Univ, Dept Occupat & Environm Hlth Sci, Morgantown, WV 26505 USA. [Januch, Jed W.] US EPA, Off Environm Assessment, Reg 10, Port Orchard, WA 98366 USA. [Jacobs, Teri A.] NIOSH, Surveillance Branch, Div Surveillance Hazard Evaluat & Field Studies, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. [Sarkisian, Khachatur] NIOSH, Biostat & Epidemiol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. [Stetler, Larry D.] South Dakota Sch Mines & Technol, Dept Geol & Geol Engn, Rapid City, SD 57701 USA. [Schwegler-Berry, Diane] NIOSH, Pathol & Physiol Res Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. RP Harper, M (reprint author), NIOSH, Exposure Assessment Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, 1095 Willowdale Rd M-S 3030, Morgantown, WV 26505 USA. EM zzg7@cdc.gov NR 28 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1866-6280 EI 1866-6299 J9 ENVIRON EARTH SCI JI Environ. Earth Sci. PD FEB PY 2017 VL 76 IS 3 AR 126 DI 10.1007/s12665-017-6438-7 PG 15 WC Environmental Sciences; Geosciences, Multidisciplinary; Water Resources SC Environmental Sciences & Ecology; Geology; Water Resources GA EL9VD UT WOS:000394967300006 ER PT J AU DeFlorio-Barker, S Wade, TJ Jones, RM Friedman, LS Wing, C Dorevitch, S AF DeFlorio-Barker, Stephanie Wade, Timothy J. Jones, Rachael M. Friedman, Lee S. Wing, Coady Dorevitch, Samuel TI Estimated Costs of Sporadic Gastrointestinal Illness Associated with Surface Water Recreation: A Combined Analysis of Data from NEEAR and CHEERS Studies SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article ID RAPIDLY MEASURED INDICATORS; MARINE WATER; QUALITY; CONTACT; DISEASE; BURDEN; RISKS; GASTROENTERITIS; INFECTIONS; COMMUNITY AB BACKGROUND: The burden of illness can be described by addressing both incidence and illness severity attributable to water recreation. Monetized as cost, attributable disease burden estimates can be useful for environmental management decisions. OBJECTIVES: We characterize the disease burden attributable to water recreation using data from two cohort studies using a cost of illness (COI) approach and estimate the largest drivers of the disease burden of water recreation. METHODS: Data from the NEEAR study, which evaluated swimming and wading in marine and freshwater beaches in six U. S. states, and CHEERS, which evaluated illness after incidental- contact recreation (boating, canoeing, fishing, kayaking, and rowing) on waterways in the Chicago area, were used to estimate the cost per case of gastrointestinal illness and costs attributable to water recreation. Data on health care and medication utilization and missed days of work or leisure were collected and combined with cost data to construct measures of COI. RESULTS: Depending on different assumptions, the cost of gastrointestinal symptoms attributable to water recreation are estimated to be $1,220 for incidental-contact recreation (range $338-$ 1,681) and $ 1,676 for swimming/wading (range $ 425-2,743) per 1,000 recreators. Lost productivity is a major driver of the estimated COI, accounting for up to 90% of total costs. CONCLUSIONS: Our estimates suggest gastrointestinal illness attributed to surface water recreation at urban waterways, lakes, and coastal marine beaches is responsible for costs that should be accounted for when considering the monetary impact of efforts to improve water quality. The COI provides more information than the frequency of illness, as it takes into account disease incidence, health care utilization, and lost productivity. Use of monetized disease severity information should be included in future studies of water quality and health. C1 [DeFlorio-Barker, Stephanie; Jones, Rachael M.; Friedman, Lee S.; Dorevitch, Samuel] Univ Illinois, Sch Publ Hlth, Div Environm & Occupat Hlth Sci, Chicago, IL USA. [Wade, Timothy J.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC USA. [Wing, Coady] Indiana Univ, Sch Publ & Environm Affairs, Bloomington, IN USA. [Dorevitch, Samuel] Univ Illinois, Inst Environm Sci & Policy, Chicago, IL USA. RP DeFlorio-Barker, S (reprint author), Div Environm & Occupat Hlth Sci, 2121 W Taylor St M-C 922, Chicago, IL 60612 USA. EM sdeflor2@uic.edu FU Metropolitan Water Reclamation District of Greater Chicago; Water Environment Research Foundation; U.S. Environmental Protection Agency (EPA) STAR agreement [RD-83478901]; U.S. EPA; Centers for Disease Control and Prevention; National Association of Clean Water Agencies (NACWA); National Science Foundation; Chicago Park District FX The CHEERS study research reported here was funded by the Metropolitan Water Reclamation District of Greater Chicago. A peer review panel for this study was supported by the Water Environment Research Foundation. Support for analyses was provided by the U.S. Environmental Protection Agency (EPA) STAR agreement (RD-83478901). The contents of this work on CHEERS are solely the responsibility of the grantee and do not necessarily represent the official views of the U.S. EPA. Further, the U.S. EPA does not endorse the purchase of any commercial products or services mentioned herein.; In the past 3 years, S.D. has received grant support from the U.S. EPA, the Centers for Disease Control and Prevention, the National Association of Clean Water Agencies (NACWA), the National Science Foundation, and the Chicago Park District. He has reviewed draft U.S. EPA water quality documents as a consultant to the Eastern Research Group. NR 46 TC 0 Z9 0 U1 0 U2 0 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD FEB PY 2017 VL 125 IS 2 BP 215 EP 222 DI 10.1289/EHP130 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA EK5ZF UT WOS:000394004000015 PM 27459727 ER PT J AU Wright, JM Evans, A Kaufman, JA Rivera-Nunez, Z Narotsky, MG AF Wright, J. Michael Evans, Amanda Kaufman, John A. Rivera-Nunez, Zorimar Narotsky, Michael G. TI Disinfection By-Product Exposures and the Risk of Specific Cardiac Birth Defects SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article ID CONGENITAL HEART-DISEASE; DRINKING-WATER; DEVELOPMENTAL TOXICITY; RESIDENTIAL-MOBILITY; PRENATAL-DIAGNOSIS; MALFORMATIONS; PREGNANCY; RAT; TRIHALOMETHANE; ASSOCIATION AB BACKGROUND: Epidemiological studies suggest that women exposed to disinfection by-products (DBPs) have an increased risk of delivering babies with cardiovascular defects (CVDs). Objective: We examined nine CVDs in relation to categorical DBP exposures including bromoform, chloroform, dibromochloromethane (DBCM), bromodichloromethane (BDCM), monobromoacetic acid (MBAA), dichloroacetic acid (DCAA), trichloroacetic acid (TCAA), and summary DBP measures (HAA5, THMBr, THM4, and DBP9). METHODS: We calculated adjusted odds ratios (aORs) in a case-control study of birth defects in Massachusetts with complete quarterly 1999-2004 trihalomethane (THM) and haloacetic acid (HAA) data. We randomly matched 10 controls each to 904 CVD cases based on week of conception. Weight-averaged aggregate first-trimester DBP exposures were assigned to individuals based on residence at birth. RESULTS: We detected associations for tetralogy of Fallot and the upper exposure categories for TCAA, DCAA, and HAA5 (aOR range, 3.34-6.51) including positive exposure-response relationships for DCAA and HAA5. aORs consistent in magnitude were detected between atrial septal defects and bromoform (aOR = 1.56; 95% CI: 1.01, 2.43), as well as DBCM, chloroform, and THM4 (aOR range, 1.26-1.67). Ventricular septal defects (VSDs) were associated with the highest bromoform (aOR = 1.85; 95% CI: 1.20, 2.83), MBAA (aOR = 1.81; 95% CI: 0.85, 3.84), and DBCM (aOR = 1.54; 95% CI: 1.00, 2.37) exposure categories. CONCLUSIONS: To our knowledge, this is the first birth defect study to develop multi-DBP adjusted regression models as well as the first CVD study to evaluate HAA exposures and the second to evaluate bromoform exposures. Our findings, therefore, inform exposure specificity for the -consistent associations previously reported between THM4 and CVDs including VSDs. C1 [Wright, J. Michael] US EPA, Natl Ctr Environm Assessment NCEA, Off Res & Dev, Cincinnati, OH 45268 USA. [Evans, Amanda] Campbell Univ, Sch Osteopath Med, Lillington, NC USA. [Kaufman, John A.] US EPA, ASPPH, EPA Environm Hlth Fellowship Program, NCEA, Cincinnati, OH 45268 USA. [Rivera-Nunez, Zorimar] Rutgers Canc Inst New Jersey, Radiat Oncol, New Brunswick, NJ USA. [Narotsky, Michael G.] US EPA, ORD, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. RP Wright, JM (reprint author), US EPA, Natl Ctr Environm Assessment, 26 W Martin Luther King Dr,MS A110, Cincinnati, OH 45268 USA. EM wright.michael@epa.gov FU Oak Ridge Institute of Science and Education Research Participation Program - U.S. EPA [DW8992376701]; U.S. EPA [X3-83555301]; Association of Schools and Programs of Public Health (ASPPH); National Academies, Research Associateship Programs - U.S. EPA FX A.E. was supported through the Oak Ridge Institute of Science and Education Research Participation Program (agreement no. DW8992376701) sponsored by the U.S. EPA. J.A.K. was supported by cooperative agreement no. X3-83555301 from the U.S. EPA and the Association of Schools and Programs of Public Health (ASPPH). Z.R.-N. was supported through The National Academies, Research Associateship Programs sponsored by the U.S. EPA. NR 42 TC 0 Z9 0 U1 2 U2 2 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD FEB PY 2017 VL 125 IS 2 BP 269 EP 277 DI 10.1289/EHP103 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA EK5ZF UT WOS:000394004000022 PM 27518881 ER PT J AU Myer, MH Henderson, WM Black, MC AF Myer, Mark H. Henderson, W. Matthew Black, Marsha C. TI Effects of multiwalled carbon nanotubes on the bioavailability and toxicity of diphenhydramine to Pimephales promelas in sediment exposures SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Nanotoxicology; Pharmaceuticals; Contaminants of emerging concern; Bioaccumulation; Carbon nanotubes ID POLYCYCLIC AROMATIC-HYDROCARBONS; ORGANIC-MATTER; ACTIVATED CARBON; EMERGING CONCERN; FATHEAD MINNOWS; ADSORPTION; WATER; PH; BIOACCUMULATION; PHARMACEUTICALS AB Multiwalled carbon nanotubes (MWCNTs) and pharmaceutical compounds are classified by the US Environmental Protection Agency as contaminants of emerging concern, with significant research devoted to determining their potential environmental and toxicological effects. Multiwalled carbon nanotubes are known to have a high adsorptive capacity for organic contaminants, leading to potential uses in water remediation; however, there is concern that co-exposure with MWCNTs may alter the bioavailability of organic compounds. Existing studies investigating MWCNT/organic contaminant co-exposures have shown conflicting results, and no study to date has examined the combined effects of MWCNTs and a common pharmaceutical. In the present study, juvenile fathead minnows (Pimephales promelas) were exposed to sublethal concentrations of the over-the-counter antihistamine diphenhydramine (DPH) in the presence of natural sediment for 10 d, with some treatment groups receiving MWCNTs. Addition of MWCNTs did not have a protective effect on DPH-related growth inhibition, and did not reduce the whole-body burden of DPH in exposed fish. Mass-balance calculations indicated that significant amounts of DPH were adsorbed to MWCNTs, and DPH concentrations in water and sediment were commensurately reduced. Bioconcentration factor and biota-sediment accumulation factor increased in the presence of MWCNTs, indicating that P. promelas accumulates DPH adsorbed to MWCNTs in sediment, likely by co-ingestion of MWCNTs during feeding from the sediment surface. Environ Toxicol Chem 2017;36:320-328. (c) 2016 SETAC C1 [Myer, Mark H.; Black, Marsha C.] Univ Georgia, Dept Environm Hlth Sci, Athens, GA 30602 USA. [Henderson, W. Matthew] US EPA, Ecosyst Res Div, Athens, GA USA. RP Myer, MH (reprint author), Univ Georgia, Dept Environm Hlth Sci, Athens, GA 30602 USA. EM myerm@uga.edu FU University of Georgia College of Public Health; First Year Odyssey Program FX The present study was funded by the University of Georgia College of Public Health and First Year Odyssey Program. The authors thank L. Tang, D. Brew, M. Hamilton, R. Pearson-Clarke, and A. Wilson for assistance in experimental setup and monitoring, and C.-Y. Tseng for providing advice and methods for nanotube functionalization. NR 39 TC 0 Z9 0 U1 2 U2 2 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD FEB PY 2017 VL 36 IS 2 BP 320 EP 328 DI 10.1002/etc.3561 PG 9 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA EL5UL UT WOS:000394686600005 PM 27442616 ER PT J AU Pelletier, M Ho, K Cantwell, M Perron, M Rocha, K Burgess, RM Johnson, R Perez, K Cardin, J Charpentier, MA AF Pelletier, Marguerite Ho, Kay Cantwell, Mark Perron, Monique Rocha, Kenneth Burgess, Robert M. Johnson, Roxanne Perez, Kenneth Cardin, John Charpentier, Michael A. TI Diagnosis of potential stressors adversely affecting benthic invertebrate communities in Greenwich Bay, Rhode Island, USA SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Stressors; Water quality; Benthic invertebrates; Multivariate statistics; Toxicant identification ID NARRAGANSETT BAY; DISSOLVED-OXYGEN; COASTAL WATERS; ESTUARINE; SEDIMENTS; MARINE; QUALITY; INDEX; PERFORMANCE; BIVALVE AB Greenwich Bay is an urbanized embayment of Narragansett Bay potentially impacted by multiple stressors. The present study identified the important stressors affecting Greenwich Bay benthic fauna. First, existing data and information were used to confirm that the waterbody was impaired. Second, the presence of source, stressor, and effect were established. Then linkages between source, stressor, and effect were developed. This allows identification of probable stressors adversely affecting the waterbody. Three pollutant categories were assessed: chemicals, nutrients, and suspended sediments. This weight of evidence approach indicated that Greenwich Bay was primarily impacted by eutrophication-related stressors. The sediments of Greenwich Bay were carbon enriched and low dissolved oxygen concentrations were commonly seen, especially in the western portions of Greenwich Bay. The benthic community was depauperate, as would be expected under oxygen stress. Although our analysis indicated that contaminant loads in Greenwich Bay were at concentrations where adverse effects might be expected, no toxicity was observed, as a result of high levels of organic carbon in these sediments reducing contaminant bioavailability. Our analysis also indicated that suspended sediment impacts were likely nonexistent for much of the Bay. This analysis demonstrates that the diagnostic procedure was useful to organize and assess the potential stressors impacting the ecological well-being of Greenwich Bay. This diagnostic procedure is useful for management of waterbodies impacted by multiple stressors. Environ Toxicol Chem 2017;36:449-462. (c) 2016 SETAC C1 [Pelletier, Marguerite; Ho, Kay; Cantwell, Mark; Rocha, Kenneth; Burgess, Robert M.; Johnson, Roxanne; Perez, Kenneth; Cardin, John] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA. [Perron, Monique] US EPA, Off Pesticide Program, Washington, DC 20460 USA. [Charpentier, Michael A.] CSRA, Narragansett, RI USA. RP Pelletier, M (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA. EM pelletier.peg@epa.gov NR 51 TC 0 Z9 0 U1 0 U2 0 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD FEB PY 2017 VL 36 IS 2 BP 449 EP 462 DI 10.1002/etc.3562 PG 14 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA EL5UL UT WOS:000394686600019 PM 27442751 ER PT J AU Fay, KA Fitzsimmons, PN Hoffman, AD Nichols, JW AF Fay, Kellie A. Fitzsimmons, Patrick N. Hoffman, Alex D. Nichols, John W. TI Comparison of trout hepatocytes and liver S9 fractions as in vitro models for predicting hepatic clearance in fish SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Hepatocytes; Liver S9 fractions; Perfused liver; Intrinsic clearance; Hepatic clearance; Bioaccumulation ID XENOBIOTIC INTRINSIC CLEARANCE; FRESHLY ISOLATED HEPATOCYTES; ONCORHYNCHUS-MYKISS; BIOACCUMULATION ASSESSMENT; MEASURED RATES; BIOCONCENTRATION; METABOLISM; ASSESSMENTS; BIOTRANSFORMATION; SUPPORT AB Isolated hepatocytes and liver S9 fractions have been used to collect in vitro biotransformation data for fish as a means of improving modeled estimates of chemical bioaccumulation. To date, however, there have been few direct comparisons of these 2 methods. In the present study, cryopreserved trout hepatocytes were used to measure in vitro intrinsic clearance rates for 6 polycyclic aromatic hydrocarbons (PAHs). These rates were extrapolated to estimates of in vivo intrinsic clearance and used as inputs to a well stirred liver model to predict hepatic clearance. Predicted rates of hepatic clearance were then evaluated by comparison with measured rates determined previously using isolated perfused livers. Hepatic clearance rates predicted using hepatocytes were in good agreement with measured values (<2.1-fold difference for 5 of 6 compounds) under 2 competing binding assumptions. These findings, which may be attributed in part to high rates of PAH metabolism, are similar to those obtained previously using data from liver S9 fractions. For 1 compound (benzo[a]pyrene), the in vivo intrinsic clearance rate calculated using S9 data was 10-fold higher than that determined using hepatocytes, possibly due to a diffusion limitation on cellular uptake. Generally, however, there was good agreement between calculated in vivo intrinsic clearance rates obtained using either in vitro test system. These results suggest that both systems can be used to improve bioaccumulation assessments for fish, particularly when vitro rates of activity are relatively high, although additional work is needed to determine if the chemical domain of applicability for each system differs. Environ Toxicol Chem 2017;36:463-471. Published 2016 SETAC. This article is a US government work and, as such, is in the public domain in the United States of America. C1 [Fay, Kellie A.; Fitzsimmons, Patrick N.; Hoffman, Alex D.; Nichols, John W.] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Midcontinent Ecol Div, Duluth, MN 55804 USA. RP Nichols, JW (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Midcontinent Ecol Div, Duluth, MN 55804 USA. EM nichols.john@epa.gov NR 30 TC 0 Z9 0 U1 0 U2 0 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD FEB PY 2017 VL 36 IS 2 BP 463 EP 471 DI 10.1002/etc.3572 PG 9 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA EL5UL UT WOS:000394686600020 PM 27487575 ER PT J AU Phelan, KD Shwe, U Cozart, MA Wu, H Mock, MM Abramowitz, J Birnbaumer, L Zheng, F AF Phelan, Kevin D. Shwe, UThaung Cozart, Michael A. Wu, Hong Mock, Matthew M. Abramowitz, Joel Birnbaumer, Lutz Zheng, Fang TI TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice SO EPILEPSIA LA English DT Article DE Beta rhythm; Electroencephalography; Gamma rhythm; Seizures; Spectral analysis; Transient receptor potential channels ID NEUROTROPHIC FACTOR; BRAIN; BDNF; SEIZURE; HIPPOCAMPUS; EPILEPTOGENESIS; OSCILLATIONS; ACTIVATION; EXPRESSION; EPILEPSY AB Objective: Canonical transient receptor potential (TRPC) channels constitute a family of cation channels that exhibit a regional and cell-specific expression pattern throughout the brain. It has been reported previously that TRPC3 channels are effectors of the brain-derived neurotrophic factor (BDNF)/trkB signaling pathway. Given the long postulated role of BDNF in epileptogenesis, TRPC3 channels may be a critical component in the underlying pathophysiology of seizure and epilepsy. In this study, we investigated the precise role of TRPC3 channels in pilocarpine-induced status epilepticus (SE). Methods: The role of TRPC3 channels was investigated using TRPC3 knockout (KO) mice and TRPC3-selective inhibitor Pyr3. Video and electroencephalography (EEG) recording of pilocarpine-induced seizures were performed. Results: We found that genetic ablation of TRPC3 channels reduces behavioral manifestations of seizures and the root-mean-square (RMS) power of SE, indicating a significant contribution of TRPC3 channels to pilocarpine-induced SE. Furthermore, the reduction in SE in TRPC3KO mice is caused by a selective attenuation of pilocarpine-induced theta activity, which dominates both the preictal phase and SE phase. Pyr3 also caused a reduction in the overall RMS power of pilocarpine-induced SE and a selective reduction in the theta activity during SE. Significance: Our results demonstrate that TRPC3 channels unequivocally contribute to pilocarpine-induced SE and could be a novel molecular target for new anticonvulsive drugs. C1 [Phelan, Kevin D.] Univ Arkansas Med Sci, Dept Neurobiol & Dev Sci, Little Rock, AR 72205 USA. [Shwe, UThaung; Cozart, Michael A.; Wu, Hong; Mock, Matthew M.; Zheng, Fang] Univ Arkansas Med Sci, Dept Pharmacol & Toxicol, 4310 W Markham St, Little Rock, AR 72205 USA. [Abramowitz, Joel; Birnbaumer, Lutz] Natl Inst Environm Hlth Sci, Neurobiol Lab, Durham, NC USA. [Birnbaumer, Lutz] Catholic Univ Argentina, Inst Biomed Res BIOMED, Buenos Aires, DF, Argentina. RP Zheng, F (reprint author), Univ Arkansas Med Sci, Dept Pharmacol & Toxicol, 4310 W Markham St, Little Rock, AR 72205 USA. EM zhengfang@uams.edu FU National Institute of Neurological Disorders and Stroke [NS050381]; National Institute of General Medical Sciences [GM103425]; University of Arkansas for Medical Sciences Hornick Research Award; Intramural Research Program of the National Institute of Health [Z01-ES 101684] FX This work was supported in part by National Institute of Neurological Disorders and Stroke [NS050381], by National Institute of General Medical Sciences [GM103425]; the University of Arkansas for Medical Sciences Hornick Research Award; and was supported in part by the Intramural Research Program of the National Institute of Health [Z01-ES 101684]. The authors declare no competing financial interests. NR 28 TC 0 Z9 0 U1 0 U2 0 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0013-9580 EI 1528-1167 J9 EPILEPSIA JI Epilepsia PD FEB PY 2017 VL 58 IS 2 BP 247 EP 254 DI 10.1111/epi.13648 PG 8 WC Clinical Neurology SC Neurosciences & Neurology GA EP3CT UT WOS:000397260900010 PM 28012173 ER PT J AU Beck, MW Murphy, RR AF Beck, Marcus W. Murphy, Rebecca R. TI Numerical and Qualitative Contrasts of Two Statistical Models for Water Quality Change in Tidal Waters SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article DE estuaries; additive models; nutrients; Patuxent River estuary; statistics; time-series analysis; weighted regression ID LONG-TERM TRENDS; CHESAPEAKE BAY; QUANTILE REGRESSION; PHYTOPLANKTON; ESTUARY; EUTROPHICATION; NUTRIENTS; RIVER; FLOW; TRIBUTARIES AB Two statistical approaches, weighted regression on time, discharge, and season and generalized additive models, have recently been used to evaluate water quality trends in estuaries. Both models have been used in similar contexts despite differences in statistical foundations and products. This study provided an empirical and qualitative comparison of both models using 29years of data for two discrete time series of chlorophyll-a (chl-a) in the Patuxent River estuary. Empirical descriptions of each model were based on predictive performance against the observed data, ability to reproduce flow-normalized trends with simulated data, and comparisons of performance with validation datasets. Between-model differences were apparent but minor and both models had comparable abilities to remove flow effects from simulated time series. Both models similarly predicted observations for missing data with different characteristics. Trends from each model revealed distinct mainstem influences of the Chesapeake Bay with both models predicting a roughly 65% increase in chl-a over time in the lower estuary, whereas flow-normalized predictions for the upper estuary showed a more dynamic pattern, with a nearly 100% increase in chl-a in the last 10years. Qualitative comparisons highlighted important differences in the statistical structure, available products, and characteristics of the data and desired analysis. C1 [Beck, Marcus W.] US EPA, Gulf Ecol Div, Natl Hlth & Environm Effects Res Lab, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA. [Murphy, Rebecca R.] Univ Maryland, Ctr Environm Sci Chesapeake Bay Program, Annapolis, MD 21403 USA. RP Beck, MW (reprint author), US EPA, Gulf Ecol Div, Natl Hlth & Environm Effects Res Lab, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA. EM beck.marcus@epa.gov NR 48 TC 1 Z9 1 U1 0 U2 0 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-474X EI 1752-1688 J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD FEB PY 2017 VL 53 IS 1 BP 197 EP 219 DI 10.1111/1752-1688.12489 PG 23 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA EL7CP UT WOS:000394779000015 ER PT J AU Rappazzo, KM Lobdell, DT Messer, LC Poole, C Daniels, JL AF Rappazzo, Kristen M. Lobdell, Danelle T. Messer, Lynne C. Poole, Charles Daniels, Julie L. TI Comparison of gestational dating methods and implications for exposure-outcome associations: an example with PM2.5 and preterm birth SO OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID LAST MENSTRUAL PERIOD; PARTICULATE MATTER; CLINICAL ESTIMATE; AGE; PREGNANCY; DATE; ULTRASOUND; HEALTH; MODEL; RISK AB Objectives Estimating gestational age is usually based on date of last menstrual period (LMP) or clinical estimation (CE); both approaches introduce potential bias. Differences in methods of estimation may lead to misclassification and inconsistencies in risk estimates, particularly if exposure assignment is also gestation-dependent. This paper examines a 'what-if' scenario in which alternative methods are used and attempts to elucidate how method choice affects observed results. Methods We constructed two 20-week gestational age cohorts of pregnancies between 2000 and 2005 (New Jersey, Pennsylvania, Ohio, USA) using live birth certificates: one defined preterm birth (PTB) status using CE and one using LMP. Within these, we estimated risk for 4 categories of preterm birth (PTBs per 10(6) pregnancies) and risk differences (RD (95% CIs)) associated with exposure to particulate matter (PM2.5). Results More births were classified preterm using LMP (16%) compared with CE (8%). RD divergences increased between cohorts as exposure period approached delivery. Among births between 28 and 31 weeks, week 7 PM2.5 exposure conveyed RDs of 44 (21 to 67) for CE and 50 (18 to 82) for LMP populations, while week 24 exposure conveyed RDs of 33 (11 to 56) and -20 (-50 to 10), respectively. Conclusions Different results from analyses restricted to births with both CE and LMP are most likely due to differences in dating methods rather than selection issues. Results are sensitive to choice of gestational age estimation, though degree of sensitivity can vary by exposure timing. When both outcome and exposure depend on estimate of gestational age, awareness of nuances in the method used for estimation is critical. C1 [Rappazzo, Kristen M.; Lobdell, Danelle T.] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Chapel Hill, NC USA. [Messer, Lynne C.] Portland State Univ, Coll Urban & Publ Affairs, Sch Community Hlth, Portland, OR 97207 USA. [Poole, Charles; Daniels, Julie L.] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. RP Rappazzo, KM (reprint author), US EPA, ORD, NHEERL, EPHD, 109 TW Alexander Dr,Mail Code 58C, Res Triangle Pk, NC 27711 USA. EM Rappazzo.kristen@epa.gov FU US Department of Energy; EPA FX This project was supported in part by an appointment to the Internship/Research Participation Programme at the Office of Research and Development, US Environmental Protection Agency, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and EPA. NR 21 TC 0 Z9 0 U1 0 U2 0 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1351-0711 EI 1470-7926 J9 OCCUP ENVIRON MED JI Occup. Environ. Med. PD FEB PY 2017 VL 74 IS 2 BP 138 EP 143 DI 10.1136/oemed-2016-103833 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA EL3KB UT WOS:000394516900009 PM 27919061 ER PT J AU Perry, SG Snyder, WH AF Perry, Steven G. Snyder, William H. TI Laboratory simulations of the atmospheric mixed-layer in flow over complex topography SO PHYSICS OF FLUIDS LA English DT Article ID CONVECTIVE BOUNDARY-LAYER; DISPERSION MODEL; STRATIFIED FLOW; AIR-FLOW; HILLS; MOUNTAINS AB A laboratory study of the influence of complex terrain on the interface between a well-mixed boundary layer and an elevated stratified layer was conducted in the towing- tank facility of the U. S. Environmental Protection Agency. The height of the mixed layer in the daytime boundary layer can have a strong influence on the concentration of pollutants within this layer. Deflections of streamlines at the height of the interface are primarily a function of hill Froude number(Fr), the ratio of mixed-layer height (z(i)) to terrain height(h), and the crosswind dimension of the terrain. The magnitude of the deflections increases as Fr increases and z(i)/ h decreases. For mixing-height streamlines that are initially below the terrain top, the response is linear with Fr; for those initially above the terrain feature the response to Fr is more complex. Once Fr exceeds about 2, the terrain-related response of the mixed layer interface decreases somewhat with increasing Fr(toward more neutral flow). Deflections are also shown to increase as the crosswind dimensions of the terrain increase. Comparisons with numerical modeling, limited field data, and other laboratory measurements reported in the literature are favorable. Additionally, visual observations of dye streamers suggest that the flow structure exhibited for our elevated inversions passing over three dimensional hills is similar to that reported in the literature for continuously stratified flow over two-dimensional hills. C1 [Perry, Steven G.; Snyder, William H.] US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. FU U.S. Environmental Protection Agency through its Office of Research and Development FX The U.S. Environmental Protection Agency through its Office of Research and Development funded and managed the research described here. The manuscript has been subjected to external peer review and has been cleared for publication. Although this work was reviewed by EPA and approved for publication, it may not necessarily reflect official agency policy. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 31 TC 0 Z9 0 U1 0 U2 0 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 1070-6631 EI 1089-7666 J9 PHYS FLUIDS JI Phys. Fluids PD FEB PY 2017 VL 29 IS 2 DI 10.1063/1.4974505 PG 10 WC Mechanics; Physics, Fluids & Plasmas SC Mechanics; Physics GA EN3IK UT WOS:000395902000005 ER PT J AU Bowers, EC McCullough, SD AF Bowers, Emma C. McCullough, Shaun D. TI Linking the Epigenome with Exposure Effects and Susceptibility: The Epigenetic Seed and Soil Model SO TOXICOLOGICAL SCIENCES LA English DT Review DE epigenetics; chromatin; susceptibility; DNA methylation; seed and soil; developmental toxicity; prenatal; reproductive and developmental toxicology; toxicoepigenetics ID DNA METHYLATION AGE; ADVERSE DRUG-REACTIONS; LIVER GENE-EXPRESSION; BISPHENOL-A EXPOSURE; NEONATAL EXPOSURE; REPRODUCTIVE-TRACT; AIR-POLLUTION; ENVIRONMENTAL EPIGENETICS; DEVELOPMENTAL EXPRESSION; CHROMATIN MODIFICATIONS AB The epigenome is a dynamic mediator of gene expression that shapes the way that cells, tissues, and organisms respond to their environment. Initial studies in the emerging field of "toxicoepigenetics" have described either the impact of an environmental exposure on the epigenome or the association of epigenetic signatures with the onset or progression of disease; however, the majority of these pioneering studies examined the relationship between discrete epigenetic modifications and the effects of a single environmental factor. Although these data provide critical blocks with which we construct our understanding of the role of the epigenome in susceptibility and disease, they are akin to individual letters in a complex alphabet that is used to compose the language of the epigenome. Advancing the use of epigenetic data to gain a more comprehensive understanding of the mechanisms underlying exposure effects, identify susceptible populations, and inform the next generation risk assessment depends on our ability to integrate these data in a way that accounts for their cumulative impact on gene regulation. Here we will review current examples demonstrating associations between the epigenetic impacts of intrinsic factors, such as such as age, genetics, and sex, and environmental exposures shape the epigenome and susceptibility to exposure effects and disease. We will also demonstrate how the "epigenetic seed and soil" model can be used as a conceptual framework to explain how epigenetic states are shaped by the cumulative impacts of intrinsic and extrinsic factors and how these in turn determine how an individual responds to subsequent exposure to environmental stressors. C1 [Bowers, Emma C.] Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC 27599 USA. [McCullough, Shaun D.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. RP McCullough, SD (reprint author), US EPA, Environm Publ Hlth Div, 104 Mason Farm Rd, Chapel Hill, NC 27514 USA. EM mccullough.shaun@epa.gov FU U.S. Environmental Protection Agency (EPA); EPA Pathfinder Innovation Project program; NIEHS Toxicology Training [T32-ES007126] FX This work was supported by U.S. Environmental Protection Agency (EPA) intramural funds and an EPA Pathfinder Innovation Project program grant awarded to S.D.M.E.C. Bowers is supported by NIEHS Toxicology Training Grant T32-ES007126. NR 100 TC 0 Z9 0 U1 1 U2 1 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD FEB PY 2017 VL 155 IS 2 BP 302 EP 314 DI 10.1093/toxsci/kfw215 PG 13 WC Toxicology SC Toxicology GA EO9YO UT WOS:000397044200003 PM 28049737 ER PT J AU Wittwehr, C Aladjov, H Ankley, G Byrne, HJ de Knecht, J Heinzle, E Klambauer, G Landesmann, B Luijten, M MacKay, C Maxwell, G Meek, ME Paini, A Perkins, E Sobanski, T Villeneuve, D Waters, KM Whelan, M AF Wittwehr, Clemens Aladjov, Hristo Ankley, Gerald Byrne, Hugh J. de Knecht, Joop Heinzle, Elmar Klambauer, Guenter Landesmann, Brigitte Luijten, Mirjam MacKay, Cameron Maxwell, Gavin Meek, M. E. (Bette) Paini, Alicia Perkins, Edward Sobanski, Tomasz Villeneuve, Dan Waters, Katrina M. Whelan, Maurice TI How Adverse Outcome Pathways Can Aid the Development and Use of Computational Prediction Models for Regulatory Toxicology SO TOXICOLOGICAL SCIENCES LA English DT Article DE Adverse Outcome Pathways; AOP; quantitative AOP; computational prediction model ID THYROID-HORMONE DISRUPTION; SPECIES TRANSLATION CHALLENGE; PITUITARY-GONADAL AXIS; RISK-ASSESSMENT; SKIN SENSITIZATION; SCIENTIFIC CONFIDENCE; COLLABORATIVE COMPETITION; POLYCHLORINATED-BIPHENYLS; ESTROGEN-RECEPTOR; CHEMICALS AB Efforts are underway to transform regulatory toxicology and chemical safety assessment from a largely empirical science based on direct observation of apical toxicity outcomes in whole organism toxicity tests to a predictive one in which outcomes and risk are inferred from accumulated mechanistic understanding. The adverse outcome pathway (AOP) framework provides a systematic approach for organizing knowledge that may support such inference. Likewise, computational models of biological systems at various scales provide another means and platform to integrate current biological understanding to facilitate inference and extrapolation. We argue that the systematic organization of knowledge into AOP frameworks can inform and help direct the design and development of computational prediction models that can further enhance the utility of mechanistic and in silico data for chemical safety assessment. This concept was explored as part of a workshop on AOP-Informed Predictive Modeling Approaches for Regulatory Toxicology held September 24-25, 2015. Examples of AOP-informed model development and its application to the assessment of chemicals for skin sensitization and multiple modes of endocrine disruption are provided. The role of problem formulation, not only as a critical phase of risk assessment, but also as guide for both AOP and complementary model development is described. Finally, a proposal for actively engaging the modeling community in AOP-informed computational model development is made. The contents serve as a vision for how AOPs can be leveraged to facilitate development of computational prediction models needed to support the next generation of chemical safety assessment. C1 [Wittwehr, Clemens; Landesmann, Brigitte; Whelan, Maurice] European Commiss, Joint Res Ctr, I-21027 Ispra, Italy. [Aladjov, Hristo] Bulgarian Acad Sci, Sofia 1113, Bulgaria. [Ankley, Gerald; Villeneuve, Dan] US Environm Protect Agcy, Duluth, MN 55804 USA. [Byrne, Hugh J.] FOCAS Res Inst, Dublin 8, Ireland. [de Knecht, Joop; Luijten, Mirjam] Natl Inst Publ Hlth & Environm RIVM, NL-3721 MA Bilthoven, Netherlands. [Heinzle, Elmar] Univ Saarland, D-66123 Saarbrucken, Germany. [Klambauer, Guenter] Johannes Kepler Univ Linz, A-4040 Linz, Austria. [MacKay, Cameron] Unilever Safety & Environmenta Assurance Ctr, Sharnbrook MK44 1LQ, Beds, England. [Perkins, Edward] US Army Engn Res, Vicksburg, MS 39180 USA. [Perkins, Edward] Dev Ctr Vicksburg, Vicksburg, MS 39180 USA. [Sobanski, Tomasz] ECHA, European Chem Agcy, Helsinki 00121, Finland. [Waters, Katrina M.] Pacific Northwest Natl Lab, Richland, WA 99352 USA. RP Wittwehr, C (reprint author), European Commiss, Joint Res Ctr, I-21027 Ispra, Italy. EM clemens.wittwehr@ec.europa.eu FU European Commission's Joint Research Centre (JRC), Ispra, Italy. FX The AOP-informed Predictive Modeling Approaches for Regulatory Toxicology Workshop (24-25 September 2015) was funded by the European Commission's Joint Research Centre (JRC), Ispra, Italy. NR 72 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD FEB PY 2017 VL 155 IS 2 BP 326 EP 336 DI 10.1093/toxsci/kfw207 PG 11 WC Toxicology SC Toxicology GA EO9YO UT WOS:000397044200005 PM 27994170 ER PT J AU Lu, HF Campbell, ET Campbell, DE Wang, CW Ren, H AF Lu, Hongfang Campbell, Elliott T. Campbell, Daniel E. Wang, Changwei Ren, Hai TI Dynamics of ecosystem services provided by subtropical forests in Southeast China during succession as measured by donor and receiver value SO ECOSYSTEM SERVICES LA English DT Article DE Dynamic of ecosystem services; Donor and receiver values; Emergy; Afforestation; Forest restoration and succession ID EMERGY; BIODIVERSITY; CONSERVATION; SYSTEMS AB The trends in the provision of ecosystem services during restoration and succession of subtropical forests and plantations were quantified, in terms of both receiver and donor values, based on a case study of a 3-step secondary succession series that included a 400-year-old subtropical forest and a 23-year history of growth on 3 subtropical forest plantations in Southeastern China. The 'People's Republic of China Forestry Standard: Forest Ecosystem Service Valuation Norms' was revised and applied to quantify the receiver values of ecosystem services, which were then compared with the emergy-based, donor values of the services. The results revealed that the efficiencies of subtropical forests and plantations in providing ecosystem services were 2 orders of magnitude higher than similar services provided by the current China economic system, and these efficiencies kept increasing over the course of succession. As a result, we conclude that afforestation is an efficient way to accelerate both the ability and efficiency of subtropical forests to provide ecosystem services. C1 [Lu, Hongfang; Ren, Hai] Chinese Acad Sci, Key Lab Vegetat Restorat & Management Degraded Ec, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China. [Campbell, Elliott T.] Maryland Dept Nat Resources, Tawes State Off Bldg 580 Taylor Ave,C-3, Annapolis, MD 21401 USA. [Campbell, Daniel E.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlant Ecol Div, 27 Tarzwell Dr, Narragansett, RI USA. [Wang, Changwei] SUNY Stony Brook, Dept Chem, Stony Brook, NY 11794 USA. [Ren, Hai] Xingke Rd 723, Guangzhou 510650, Guangdong, Peoples R China. RP Ren, H (reprint author), Chinese Acad Sci, Key Lab Vegetat Restorat & Management Degraded Ec, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China. EM luhf@scbg.ac.cn; ecapm88@gmail.com; Campbell.Dan@epa.gov; changwei.wang@stonybrook.edu; renhai@scbg.ac.cn FU Strategic Priority Research Program of the Chinese Academy of Sciences [XDA13020505]; Project of Science & Technology Plan of Guangdong Province [2014A030305014, 2015A030303014] FX This study is supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA13020505), and the Project of Science & Technology Plan of Guangdong Province (2014A030305014, 2015A030303014). We would like to thank the Heshan National Field Research Station of Forest Ecosystems (HNFRSFE) for providing detailed community investigation and monitor data of the three forest plantations under this study. We would like to thank the three anonymous reviewers for very helpful comments and suggestions that improved the manuscript. NR 58 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 2212-0416 J9 ECOSYST SERV JI Ecosyst. Serv. PD FEB PY 2017 VL 23 BP 248 EP 258 DI 10.1016/j.ecoser.2016.11.012 PG 11 WC Ecology; Environmental Sciences; Environmental Studies SC Environmental Sciences & Ecology GA EO9CG UT WOS:000396986200024 ER PT J AU Aal, GA Atekwana, EA Werkema, DD AF Aal, Gamal Abdel Atekwana, Estella A. Werkema, D. Dale, Jr. TI Complex conductivity response to silver nanoparticles in partially saturated sand columns SO JOURNAL OF APPLIED GEOPHYSICS LA English DT Article DE Nanopartides; Complex conductivity; Nanosilver; Environmental nanomaterials ID SPECTRAL-INDUCED POLARIZATION; POROUS-MEDIA; ENGINEERED NANOMATERIALS; METALLIC NANOPARTICLES; ELECTRICAL-PROPERTIES; MAGNETIC-RESONANCE; IRON PARTICLES; IN-VITRO; TRANSPORT; SOILS AB The increase in the use of nanoscale materials in consumer products has resulted in a growing concern of their potential hazard to ecosystems and public health from their accidental or intentional introduction to the environment. Key environmental, health, and safety research needs include knowledge and methods for their detection, characterization, fate, and transport. Specifically, techniques available for the direct detection and quantification of their fate and transport in the environment are limited. Their small size, high surface area to volume ratio, interfacial, and electrical properties make metallic nanoparticles, such as silver nanoparticles, good targets for detection using electrical geophysical techniques. Here we measured the complex conductivity response to silver nanoparticles in sand columns under varying moisture conditions (0-30%), nanoparticle concentrations (010 mg/g), lithology (presence of clay), pore water salinity (0.0275 and 0.1000 S/m), and particle size (35, 90210 and 1500-2500 nm). Based on the Cole-Cole relaxation models we obtained the chargeability and the time constant. We demonstrate that complex conductivity can detect silver nanoparticles in porous media with the response enhanced by higher concentrations of silver nanoparticles, moisture content, ionic strength, clay content and particle diameter. Quantification of the volumetric silver nanoparticles content in the porous media can also be obtained from complex conductivity parameters based on the strong power law relationships. (C) 2016 Elsevier B.V. All rights reserved. C1 [Aal, Gamal Abdel; Atekwana, Estella A.] Oklahoma State Univ, Stillwater, OK 74078 USA. [Aal, Gamal Abdel] Assiut Univ, Dept Geol, Fac Sci, Assiut, Egypt. [Werkema, D. Dale, Jr.] US EPA, ORD, NERL, EMMD,ECB, Las Vegas, NV 89193 USA. RP Atekwana, EA (reprint author), Oklahoma State Univ, Boone Pickens Sch Geol, 105 Noble Res Ctr, Stillwater, OK 74078 USA. EM estella.atekwana@okstate.edu FU United States Environmental Protection Agency through its Office of Research and Development student services [EP09D000553]; office of the Dean, College of Arts and Sciences, Oklahoma State University FX The United States Environmental Protection Agency through its Office of Research and Development student services contract # EP09D000553 partially funded and collaborated in this research. It has been subjected to Agency review and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. GA was funded by the office of the Dean, College of Arts and Sciences, Oklahoma State University. This is the Boone Pickens School of Geology Contribution 2016-45. NR 72 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0926-9851 EI 1879-1859 J9 J APPL GEOPHYS JI J. Appl. Geophys. PD FEB PY 2017 VL 137 BP 73 EP 81 DI 10.1016/j.jappgeo.2016.12.013 PG 9 WC Geosciences, Multidisciplinary; Mining & Mineral Processing SC Geology; Mining & Mineral Processing GA EN2LJ UT WOS:000395841400008 ER PT J AU Fant, C Srinivasan, R Boehlert, B Rennels, L Chapra, SC Strzepek, KM Corona, J Allen, A Martinich, J AF Fant, Charles Srinivasan, Raghavan Boehlert, Brent Rennels, Lisa Chapra, Steven C. Strzepek, Kenneth M. Corona, Joel Allen, Ashley Martinich, Jeremy TI Climate Change Impacts on US Water Quality Using Two Models: HAWQS and US Basins SO WATER LA English DT Article DE water quality; climate change; economic valuation; mitigation; greenhouse gases; model comparison ID LARGE-SCALE; SWAT; RESERVOIRS; LAKES AB Climate change and freshwater quality are well-linked. Changes in climate result in changes in streamflow and rising water temperatures, which impact biochemical reaction rates and increase stratification in lakes and reservoirs. Using two water quality modeling systems (the Hydrologic and Water Quality System; HAWQS and US Basins), five climate models, and two greenhouse gas (GHG) mitigation policies, we assess future water quality in the continental U.S. to 2100 considering four water quality parameters: water temperature, dissolved oxygen, total nitrogen, and total phosphorus. Once these parameters are aggregated into a water quality index, we find that, while the water quality models differ under the baseline, there is more agreement between future projections. In addition, we find that the difference in national-scale economic benefits across climate models is generally larger than the difference between the two water quality models. Both water quality models find that water quality will more likely worsen in the East than in the West. Under the business-as-usual emissions scenario, we find that climate change is likely to cause economic impacts ranging from 1.2 to 2.3 (2005 billion USD/year) in 2050 and 2.7 to 4.8 in 2090 across all climate and water quality models. C1 [Fant, Charles; Boehlert, Brent; Rennels, Lisa] Ind Econ Inc, Cambridge, MA 02140 USA. [Srinivasan, Raghavan] Texas A&M Univ, Dept Ecosyst Sci & Management & Biol & Agr Engn, College Stn, TX 77843 USA. [Boehlert, Brent; Strzepek, Kenneth M.] MIT, Joint Program Sci & Policy Global Change, 77 Massachusetts Ave, Cambridge, MA 02139 USA. [Chapra, Steven C.] Tufts Univ, Civil & Environm Engn, Medford, MA 02155 USA. [Corona, Joel; Allen, Ashley; Martinich, Jeremy] US EPA, Washington, DC 20460 USA. RP Fant, C (reprint author), Ind Econ Inc, Cambridge, MA 02140 USA. EM cfant@indecon.com; r-srinivasan@tamu.edu; BBoehlert@indecon.com; lrennels@indecon.com; steven.chapra@tufts.edu; strzepek@mit.edu; Corona.Joel@epa.gov; Allen.Ashley@epa.gov; Martinich.Jeremy@epa.gov RI Chapra, Steven/A-5752-2008; OI Chapra, Steven/0000-0003-0238-6376; Srinivasan, Raghavan/0000-0001-8375-6038 FU U.S. Environmental Protection Agency's (EPA's) Climate Change Division [EP-BPA-12-H-0024]; Office of Water [EP-G15H-01113] FX We acknowledge the financial support of the U.S. Environmental Protection Agency's (EPA's) Climate Change Division (Contract #EP-BPA-12-H-0024), and Office of Water (Contract #EP-G15H-01113), and access to reservoir datasets from the U.S. Army Corps of Engineers. Arndt Gossel, Karen Metchis, Michael Trombley, Pravin Rana, and Isabella Morin provided support on the scope and direction of the study and technical contributions provided by Jacqueline Willwerth. Data used to produce the results of this paper can be made available through the corresponding author, Charles Fant (cfant@indecon.com). The views expressed in this article are solely those of the authors, and do not necessarily reflect the views of their organizations. NR 45 TC 0 Z9 0 U1 0 U2 0 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 2073-4441 J9 WATER-SUI JI Water PD FEB PY 2017 VL 9 IS 2 AR 118 DI 10.3390/w9020118 PG 21 WC Water Resources SC Water Resources GA EM6PY UT WOS:000395435800048 ER PT J AU Yen, H Lu, SL Feng, QY Wang, RY Gao, JG Brady, DM Sharifi, A Ahn, J Chen, ST Jeong, J White, MJ Arnold, JG AF Yen, Haw Lu, Shenglan Feng, Qingyu Wang, Ruoyu Gao, Jungang Brady, Dawn Michelle Sharifi, Amirreza Ahn, Jungkyu Chen, Shien-Tsung Jeong, Jaehak White, Michael James Arnold, Jeffrey George TI Assessment of Optional Sediment Transport Functions via the Complex Watershed Simulation Model SWAT SO WATER LA English DT Article DE sediment transport; model calibration; SWAT; uncertainty analysis; IPEAT ID UNCERTAINTY; CALIBRATION; NITROGEN; SOIL; VULNERABILITY; PERFORMANCE; PHOSPHORUS; CATCHMENT; FRAMEWORK; POLLUTION AB The Soil and Water Assessment Tool 2012 (SWAT2012) offers four sediment routing methods as optional alternatives to the default simplified Bagnold method. Previous studies compared only one of these alternative sediment routing methods with the default method. The proposed study evaluated the impacts of all four alternative sediment transport methods on sediment predictions: the modified Bagnold equation, the Kodoatie equation, the Molinas and Wu equation, and the Yang equation. The Arroyo Colorado Watershed, Texas, USA, was first calibrated for daily flow. The sediment parameters were then calibrated to monthly sediment loads, using each of the four sediment routing equations. An automatic calibration toolIntegrated Parameter Estimation and Uncertainty Analysis Tool (IPEAT)was used to fit model parameters. The four sediment routing equations yielded substantially different sediment sources and sinks. The Yang equation performed best, followed by Kodoatie, Bagnold, and Molinas and Wu equations, according to greater model goodness-of-fit (represented by higher Nash-Sutcliffe Efficiency coefficient and percent bias closer to 0) as well as lower model uncertainty (represented by inclusion of observed data within 95% confidence interval). Since the default method (Bagnold) does not guarantee the best results, modelers should carefully evaluate the selection of alternative methods before conducting relevant studies or engineering projects. C1 [Yen, Haw; Gao, Jungang; Jeong, Jaehak] Texas A&M Univ, Blackland Res & Extens Ctr, 720 East Blackland Rd, Temple, TX 76502 USA. [Lu, Shenglan] Aarhus Univ, Dept Biosci, Vejlsovej 27, DK-8600 Silkeborg, Denmark. [Feng, Qingyu] Purdue Univ, Dept Agr & Biol Engn, Hovde Hall,610 Purdue Mall, W Lafayette, IN 47907 USA. [Wang, Ruoyu] US EPA, Integrated Environm Modeling Branch, Raleigh, NC 27695 USA. [Brady, Dawn Michelle] Aqua Aerob Syst Inc, 6306 N Alpine Rd, Loves Pk, IL 61111 USA. [Sharifi, Amirreza] Univ Maryland, Dept Environm Sci & Technol, College Pk, MD 20742 USA. [Ahn, Jungkyu] Incheon Natl Univ, Dept Civil & Environm Engn, 119 Acad Ro, Incheon 22012, South Korea. [Chen, Shien-Tsung] Feng Chia Univ, Dept Water Resources Engn & Conservat, Taichung 40724, Taiwan. [White, Michael James; Arnold, Jeffrey George] USDA ARS, Grassland Soil & Water Res Lab, 808 East Blackland Rd, Temple, TX 76502 USA. RP Yen, H (reprint author), Texas A&M Univ, Blackland Res & Extens Ctr, 720 East Blackland Rd, Temple, TX 76502 USA. EM haw.yen@gmail.com; sl@dmu.dk; feng37@purdue.edu; wang1283@purdue.edu; jgao@brc.tamus.edu; dawn.brady7@gmail.com; Amirreza.Sharifi@ARS.USDA.GOV; ahnjk@inu.ac.kr; stchen@fcu.edu.tw; jjeong@brc.tamus.edu; Mike.White@ARS.USDA.GOV; Jeff.Arnold@ARS.USDA.GOV OI Yen, Haw/0000-0002-5509-8792 FU Incheon National University International Cooperative Research Grant; United States Department of Agriculture-Natural Resources Conservation Service (USDA-NRCS) Conservation Effects Assessment Project (CEAP)-Wildlife and Cropland components; Korea Ministry of Environment (MOE) as the Environmental Health Action Program [2015001370003]; Ministry of Science and Technology in Taiwan, Republic of China [MOST 103-2811-M-006-050] FX This project study was supported funded by grants from the Incheon National University International Cooperative Research Grant in 2016, the United States Department of Agriculture-Natural Resources Conservation Service (USDA-NRCS) Conservation Effects Assessment Project (CEAP)-Wildlife and Cropland components, and from Korea Ministry of Environment (MOE) as the Environmental Health Action Program (Grant No. 2015001370003). The authors also appreciate the continuous support from the Ministry of Science and Technology in Taiwan, Republic of China (MOST 103-2811-M-006-050). NR 60 TC 0 Z9 0 U1 0 U2 0 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 2073-4441 J9 WATER-SUI JI Water PD FEB PY 2017 VL 9 IS 2 AR 76 DI 10.3390/w9020076 PG 19 WC Water Resources SC Water Resources GA EM6PY UT WOS:000395435800007 ER PT J AU Escher, BI Hackermuller, J Polte, T Scholz, S Aigner, A Altenburger, R Bohme, A Bopp, SK Brack, W Busch, W Chadeau-Hyam, M Covaci, A Eisentrager, A Galligan, JJ Garcia-Reyero, N Hartung, T Hein, M Herberth, G Jahnke, A Kleinjans, J Kluver, N Krauss, M Lamoree, M Lehmann, I Luckenbach, T Miller, GW Muller, A Phillips, DH Reemtsma, T Rolle-Kampczyk, U Schuurmann, G Schwikowski, B Tan, YM Trump, S Walter-Rohde, S Wambaugh, JF AF Escher, Beate I. Hackermuller, Joerg Polte, Tobias Scholz, Stefan Aigner, Achim Altenburger, Rolf Boehme, Alexander Bopp, Stephanie K. Brack, Werner Busch, Wibke Chadeau-Hyam, Marc Covaci, Adrian Eisentraeger, Adolf Galligan, James J. Garcia-Reyero, Natalia Hartung, Thomas Hein, Michaela Herberth, Gunda Jahnke, Annika Kleinjans, Jos Kluever, Nils Krauss, Martin Lamoree, Marja Lehmann, Irina Luckenbach, Till Miller, Gary W. Mueller, Andrea Phillips, David H. Reemtsma, Thorsten Rolle-Kampczyk, Ulrike Schueuermann, Gerrit Schwikowski, Benno Tan, Yu-Mei Trump, Saskia Walter-Rohde, Susanne Wambaugh, John F. TI From the exposome to mechanistic understanding of chemical-induced adverse effects SO ENVIRONMENT INTERNATIONAL LA English DT Review DE Exposome; AOP; Systems toxicology; Systems biology; Systems chemistry; Risk assessment ID EFFECT-DIRECTED ANALYSIS; INTEGRATED TESTING STRATEGIES; ENVIRONMENTAL RISK-ASSESSMENT; HUMAN HAZARD CHARACTERIZATION; GENE-EXPRESSION DATA; OUTCOME PATHWAYS; PERFLUORINATED COMPOUNDS; ORGANIC MICROPOLLUTANTS; SYSTEMS TOXICOLOGY; SAFETY ASSESSMENT AB The exposome encompasses an individual's exposure to exogenous chemicals, as well as endogenous chemicals that are produced or altered in response to external stressors. While the exposome concept has been established for human health, its principles can be extended to include broader ecological issues. The assessment of exposure is tightly interlinked with hazard assessment. Here, we explore if mechanistit understanding of the causal links between exposure and adverse effects on human health and the environment can be improved by integrating the exposome approach with the adverse outcome pathway (AOP) concept that structures and organizes the sequence of biological events from an initial molecular interaction of a chemical with a biological target to an adverse outcome. Complementing exposome research with the AOP concept may facilitate a mechanistic understanding of stress-induced adverse effects, examine the relative contributions from various components of the exposome, determine the primary risk drivers in complex mixtures, and promote an integrative assessment of chemical risks for both human and environmental health. (C) 2016 The Authors. Published by Elsevier Ltd. C1 [Escher, Beate I.; Hackermuller, Joerg; Polte, Tobias; Scholz, Stefan; Altenburger, Rolf; Boehme, Alexander; Brack, Werner; Busch, Wibke; Hein, Michaela; Herberth, Gunda; Jahnke, Annika; Kluever, Nils; Krauss, Martin; Lehmann, Irina; Luckenbach, Till; Mueller, Andrea; Reemtsma, Thorsten; Rolle-Kampczyk, Ulrike; Schueuermann, Gerrit; Trump, Saskia] UFZ Helmholtz Ctr Environm Res, Permoserstr 15, D-04318 Leipzig, Germany. [Aigner, Achim] Univ Leipzig, Rudolf Boehm Inst Pharmacol & Toxicol, Clin Pharmacol, Haertelstr 16-18, D-04107 Leipzig, Germany. [Bopp, Stephanie K.] European Commiss Joint Res Ctr, Directorate Hlth Consumers & Reference Mat F, Via E Fermi 2749, I-21027 Ispra, VA, Italy. [Chadeau-Hyam, Marc] Univ London, Imperial Coll, Dept Epidemiol & Biostat, Sch Publ Hlth, St Marys Campus,Norfolk Pl, London W2 1PG, England. [Covaci, Adrian] Univ Antwerp, Toxicol Ctr, Univ Pl 1, B-2610 Antwerp, Belgium. [Eisentraeger, Adolf; Walter-Rohde, Susanne] German Environm Agcy UBA, Dessau Rosslau, Germany. [Galligan, James J.] Vanderbilt Univ, Sch Med, AB Hancock Jr Mem Lab Canc Res, Dept Biochem, Nashville, TN 37232 USA. [Garcia-Reyero, Natalia] US Army Engineer Res & Dev Ctr, Vicksburg, MS USA. [Garcia-Reyero, Natalia] Mississippi State Univ, Starkville, MS USA. [Hartung, Thomas] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Hartung, Thomas] Univ Konstanz, Constance, Germany. [Kleinjans, Jos] Maastricht Univ, Dept Toxicogen, NL-6200 MD Maastricht, Netherlands. [Lamoree, Marja] Vrije Univ Amsterdam, Fac Earth & Life Sci, Inst Environm Studies, NL-1081 HV Amsterdam, Netherlands. [Miller, Gary W.] Emory Univ, Rollins Sch Publ Hlth, Dept Environm Hlth, Atlanta, GA 30322 USA. [Phillips, David H.] Kings Coll London, MRC PHE Ctr Environm & Hlth, Analyt & Environm Sci Div, London SE1 9NH, England. [Schueuermann, Gerrit] Tech Univ Bergakad Freiberg, Inst Organ Chem, D-09596 Freiberg, Germany. [Schwikowski, Benno] Inst Pasteur, Syst Biol Lab, Paris, France. [Tan, Yu-Mei] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Wambaugh, John F.] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA. RP Escher, BI (reprint author), UFZ Helmholtz Ctr Environm Res, Dept Cell Toxicol, Permoserstr 15, D-04318 Leipzig, Germany. EM beate.escher@ufz.de RI Hackermuller, Jorg/F-2494-2016; Schuurmann, Gerrit/E-7962-2017 OI Hackermuller, Jorg/0000-0003-4920-7072; Schuurmann, Gerrit/0000-0002-3789-1703 FU Integrated Project "Exposome" at UFZ FX This review was informed by a Workshop organized by the Integrated Project EXPOSOME at the UFZ Helmholtz Centre for Environmental Research in Leipzig, Germany, in December 2015. The workshop participants comprised all coauthors plus Stephen M. Rappaport (University of California, Berkeley), Kai-Uwe Goss (UFZ) and Urs Berger (UFZ). We thank the Integrated Project "Exposome" at UFZ for funding of the workshop. We thank Stephen M. Rappaport for helpful discussions and review of the manuscript. The views expressed in this paper are those of the authors and do not necessarily reflect the views or policies of the European Commission, the German Environment Agency or the U.S. EPA. The authors declare they have no actual or potential competing financial interests. NR 99 TC 0 Z9 0 U1 2 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0160-4120 EI 1873-6750 J9 ENVIRON INT JI Environ. Int. PD FEB PY 2017 VL 99 BP 97 EP 106 DI 10.1016/j.envint.2016.11.029 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA EK6UZ UT WOS:000394062700008 PM 27939949 ER PT J AU Pang, CF Hristozov, D Zabeo, A Pizzol, L Tsang, MP Sayre, P Marcomini, A AF Pang, Chengfang Hristozov, Danail Zabeo, Alex Pizzol, Lisa Tsang, Michael P. Sayre, Phil Marcomini, Antonio TI Probabilistic approach for assessing infants' health risks due to ingestion of nanoscale silver released from consumer products SO ENVIRONMENT INTERNATIONAL LA English DT Article DE Silver nanoparticles; Human health risk assessment; Engineered nanomaterials; Stochastic risk assessment ID ORAL TOXICITY; NANOPARTICLES; CELLS; RATS; NANOMATERIALS; CYTOTOXICITY; APOPTOSIS; NANO AB Silver nanoparticles (n-Ag) are widely used in consumer products and many medical applications because of their unique antibacterial properties. Their use is raising concern about potential human exposures and health effects. Therefore, it is informative to assess the potential human health risks of n-Ag in order to ensure that nano technology-based consumer products are deployed in a safe and sustainable way. Even though toxicity studies clearly show the potential hazard of n-Ag, there have been few attempts to integrate hazard and exposure assessments to evaluate risks. The underlying reason for this is the difficulty in characterizing exposure and the lack of toxicity studies essential for human health risk assessment (HHRA). Such data gaps introduce significant uncertainty into the risk assessment process. This study uses probabilistic methods to assess the relative uncertainty and potential risks of n-Ag exposure to infants. In this paper, we estimate the risks for infants potentially exposed to n-Ag through drinking juice or milk from sippy cups or licking baby blankets containing n-Ag. We explicitly evaluate uncertainty and variability contained in available dose-response and exposure data in order to make the risk characterization process transparent. Our results showed that individual margin of exposures for oral exposure to sippy cups and baby blankets containing n-Ag exhibited minimal risk. (C) 2016 Published by Elsevier Ltd. C1 [Pang, Chengfang; Hristozov, Danail; Zabeo, Alex; Pizzol, Lisa; Marcomini, Antonio] Ca Foscari Univ Venice, Dept Environm Sci Informat & Stat, Via Torino 155, I-30172 Venice, VE, Italy. [Hristozov, Danail; Zabeo, Alex; Pizzol, Lisa] Green Decis Srl, Genoa, Italy. [Tsang, Michael P.] Univ Bordeaux, ISM, UMR 5255, F-33400 Talence, France. [Tsang, Michael P.] Univ Bordeaux, CNRS, ISM, UMR 5255, F-33400 Talence, France. [Sayre, Phil] US EPA, Washington, DC 20460 USA. RP Marcomini, A (reprint author), Ca Foscari Univ Venice, Dept Environm Sci Informat & Stat, Via Torino 155, I-30172 Venice, VE, Italy. EM marcom@unive.it FU European Commission in the frame of the FP7 project SUN [604305]; European Commission Horizon Marie Sklodowska-Curie Individual Fellowships NanoERA [66096]; European Cooperation in Science and Technology (COST) Modeling Nanomaterial Toxicity (MODENA) Initiative FX This research was funded by the European Commission in the frame of the FP7 project SUN (grant agreement No. 604305). The first author was partially supported by European Commission Horizon 2020 Marie Sklodowska-Curie Individual Fellowships NanoERA (grant agreement No. 66096). Funding was also provided by the European Cooperation in Science and Technology (COST) Modeling Nanomaterial Toxicity (MODENA) Initiative (www.modena-cost.eu) to Michael Tsang as a short-term scientific mission from University of Bordeaux to Ca'Foscari University in Venice, Italy. The authors would like to thank Dr. John Vandenberg from the U.S. EPA for reviewing the manuscript and suggesting important improvements. Dr. Steffen Foss Hansen and Aiga Mackevica from DTU provided useful information on the n-Ag release from products. Drs. Bas Bokkers, Wout Slob and Ilse Gosens from RIVM helped with valuable advice on the dose-response assessment as well as training in using the PROAST model. Drs. Tianyin Sun and Qiaoguo Tan helped with exposure model and provided training in using the Crystal Ball software. NR 44 TC 0 Z9 0 U1 1 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0160-4120 EI 1873-6750 J9 ENVIRON INT JI Environ. Int. PD FEB PY 2017 VL 99 BP 199 EP 207 DI 10.1016/j.envint.2016.11.017 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA EK6UZ UT WOS:000394062700018 PM 27894512 ER PT J AU Uzarski, DG Brady, VJ Cooper, MJ Wilcox, DA Albert, DA Axler, RP Bostwick, P Brown, TN Ciborowski, JJH Danz, NP Gathman, JP Gehring, TM Grabas, GP Garwood, A Howe, RW Johnson, LB Lamberti, GA Moerke, AH Murry, BA Niemi, GJ Norment, CJ Ruetz, CR Steinman, AD Tozer, DC Wheeler, R O'Donnell, TK Schneider, JP AF Uzarski, Donald G. Brady, Valerie J. Cooper, Matthew J. Wilcox, Douglas A. Albert, Dennis A. Axler, Richard P. Bostwick, Peg Brown, Terry N. Ciborowski, Jan J. H. Danz, Nicholas P. Gathman, Joseph P. Gehring, Thomas M. Grabas, Greg P. Garwood, Anne Howe, Robert W. Johnson, Lucinda B. Lamberti, Gary A. Moerke, Ashley H. Murry, Brent A. Niemi, Gerald J. Norment, Christopher J. Ruetz, Carl R., III Steinman, Alan D. Tozer, Douglas C. Wheeler, Ryan O'Donnell, T. Kevin Schneider, John P. TI Standardized Measures of Coastal Wetland Condition: Implementation at a Laurentian Great Lakes Basin-Wide Scale SO WETLANDS LA English DT Article DE Ecosystem health; Wetlands; Indices of biotic integrity; Great Lakes; Disturbance; IBI; Stressor; Monitoring ID POINT-COUNT SURVEYS; BIOTIC INTEGRITY; ECOLOGICAL CONDITION; ENVIRONMENTAL INDICATORS; FISH HABITAT; LAND-USE; INDEX; HURON; QUALITY; COMMUNITIES AB Since European settlement, over 50 % of coastal wetlands have been lost in the Laurentian Great Lakes basin, causing growing concern and increased monitoring by government agencies. For over a decade, monitoring efforts have focused on the development of regional and organism-specific measures. To facilitate collaboration and information sharing between public, private, and government agencies throughout the Great Lakes basin, we developed standardized methods and indicators used for assessing wetland condition. Using an ecosystem approach and a stratified random site selection process, birds, anurans, fish, macroinvertebrates, vegetation, and physico-chemical conditions were sampled in coastal wetlands of all five Great Lakes including sites from the United States and Canada. Our primary objective was to implement a standardized basin-wide coastal wetland monitoring program that would be a powerful tool to inform decision-makers on coastal wetland conservation and restoration priorities throughout the Great Lakes basin. C1 [Uzarski, Donald G.; Gehring, Thomas M.; Murry, Brent A.; Wheeler, Ryan] Cent Michigan Univ, Inst Great Lakes Res, Mt Pleasant, MI 48859 USA. [Uzarski, Donald G.; Gehring, Thomas M.; Murry, Brent A.; Wheeler, Ryan] Cent Michigan Univ, CMU Biol Stn, Mt Pleasant, MI 48859 USA. [Brady, Valerie J.; Axler, Richard P.; Brown, Terry N.; Johnson, Lucinda B.; Niemi, Gerald J.] Univ Minnesota, Nat Resources Res Inst, Duluth, MN 55811 USA. [Cooper, Matthew J.; Lamberti, Gary A.] Univ Notre Dame, Notre Dame, IN 46556 USA. [Cooper, Matthew J.] Northland Coll, Burke Ctr Freshwater Innovat, Ashland, WI USA. [Wilcox, Douglas A.; Norment, Christopher J.] SUNY Coll Brockport, Dept Environm Sci & Biol, Brockport, NY 14420 USA. [Albert, Dennis A.] Oregon State Univ, Corvallis, OR 97331 USA. [Bostwick, Peg; Garwood, Anne] Michigan Dept Environm Qual, Lansing, MI USA. [Ciborowski, Jan J. H.] Univ Windsor, Windsor, ON, Canada. [Danz, Nicholas P.] Univ Wisconsin, Superior, WI USA. [Gathman, Joseph P.] Univ Wisconsin, River Falls, WI 54022 USA. [Grabas, Greg P.] Environm & Climate Change Canada, Toronto, ON, Canada. [Howe, Robert W.] Univ Wisconsin, Green Bay, WI 54302 USA. [Moerke, Ashley H.] Lake Super State Univ, Aquat Res Lab, Sault Ste Marie, MI USA. [Ruetz, Carl R., III; Steinman, Alan D.] Grand Valley State Univ, Annis Water Resources Inst, Muskegon, MI USA. [Tozer, Douglas C.] Bird Studies Canada, Port Rowan, ON, Canada. [O'Donnell, T. Kevin; Schneider, John P.] US EPA, Great Lakes Natl Program Off, Chicago, IL USA. RP Uzarski, DG (reprint author), Cent Michigan Univ, Inst Great Lakes Res, Mt Pleasant, MI 48859 USA.; Uzarski, DG (reprint author), Cent Michigan Univ, CMU Biol Stn, Mt Pleasant, MI 48859 USA. EM uzars1dg@cmich.edu FU Great Lakes National Program Office under the United States Environmental Protection Agency as part of the US federal government's Great Lakes Restoration Initiative [GL-00E00612-0]; United States Environmental Protection Agency FX Neil Schock, David Schuberg, Alexandra Bozimowski, and Thomas Langer reviewed the manuscript. We also thank the editor, associate editor and two referees for their substantial contributions. Drs. Leah Minc and Alan Tepley assisted in the data analyses that led to the current plant metrics. The research was carried out by researchers from 11 US and Canadian universities, the Michigan Department of Environmental Quality, the Canadian Wildlife Service, and Bird Studies Canada. Funding for this work was provided by the Great Lakes National Program Office under the United States Environmental Protection Agency, grant number GL-00E00612-0 as part of the US federal government's Great Lakes Restoration Initiative. Although the research described in this work has been partly funded by the United States Environmental Protection Agency, it has not been subjected to the agency's required peer and policy review and therefore does not necessarily reflect the views of the agency and no official endorsement should be inferred. This paper is Contribution Number 76 of the Central Michigan University Institute for Great Lakes Research and Contribution Number 613 of the Natural Resources Research Institute, University of Minnesota-Duluth. NR 81 TC 0 Z9 0 U1 3 U2 3 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0277-5212 EI 1943-6246 J9 WETLANDS JI Wetlands PD FEB PY 2017 VL 37 IS 1 BP 15 EP 32 DI 10.1007/s13157-016-0835-7 PG 18 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA EK7VZ UT WOS:000394134600002 ER PT J AU LeDuc, SD Zhang, XS Clark, CM Izaurralde, RC AF LeDuc, Stephen D. Zhang, Xuesong Clark, Christopher M. Izaurralde, R. Cesar TI Cellulosic feedstock production on Conservation Reserve Program land: potential yields and environmental effects SO GLOBAL CHANGE BIOLOGY BIOENERGY LA English DT Article DE biofuel; biomass; carbon; Conservation Reserve Program; erosion; nitrogen; no-till corn; residue removal; switchgrass ID SOIL ORGANIC-CARBON; BIOENERGY PRODUCTION; LONG-TERM; CROP PRODUCTION; SEQUESTRATION; DYNAMICS; ENERGY; SCALE; SWITCHGRASS; GRASSLANDS AB Producing biofuel feedstocks on current agricultural land raises questions of a food-vs.-fuel' trade-off. The use of current or former Conservation Reserve Program (CRP) land offers an alternative; yet the volumes of ethanol that could be produced and the potential environmental impacts of such a policy are unclear. Here, we applied the Environmental Policy Integrated Climate model to a US Department of Agriculture database of over 200000 CRP polygons in Iowa, USA, as a case study. We simulated yields and environmental impacts of growing three cellulosic biofuel feedstocks on CRP land: (i) an Alamo-variety switchgrass (Panicum virgatum L.); (ii) a generalized mixture of C4 and C3 grasses; (iii) and no-till corn (Zea mays L.) with residue removal. We simulated yields, soil erosion, and soil carbon (C) and nitrogen (N) stocks and fluxes. We found that although no-till corn with residue removal produced approximately 2.6-4.4 times more ethanol per area compared to switchgrass and the grass mixture, it also led to 3.9-4.5 times more erosion, 4.4-5.2 times more cumulative N loss, and a 10% reduction in total soil carbon as opposed to a 6-11% increase. Switchgrass resulted in the best environmental outcomes even when expressed on a per liter ethanol basis. Our results suggest planting no-till corn with residue removal should only be done on low slope soils to minimize environmental concerns. Overall, this analysis provides additional information to policy makers on the potential outcome and effects of producing biofuel feedstocks on current or former conservation lands. C1 [LeDuc, Stephen D.; Clark, Christopher M.] US EPA, Natl Ctr Environm Assessment, 1200 Penn Ave NW,8623P, Washington, DC 20460 USA. [Zhang, Xuesong] Pacific Northwest Natl Lab, Joint Global Change Res Inst, 5825 Univ Res Court,Suite 1200, College Pk, MD 20740 USA. [Zhang, Xuesong; Izaurralde, R. Cesar] Michigan State Univ, Great Lakes Bioenergy Res Ctr, E Lansing, MI 48824 USA. [Izaurralde, R. Cesar] Univ Maryland, Dept Geog Sci, College Pk, MD 20742 USA. [Izaurralde, R. Cesar] Texas A&M Univ, Texas AgriLife Res, Temple, TX 76502 USA. RP LeDuc, SD (reprint author), US EPA, Natl Ctr Environm Assessment, 1200 Penn Ave NW,8623P, Washington, DC 20460 USA. EM leduc.stephen@epa.gov FU US EPA Biofuel Research Initiative; US DOE Great Lakes Bioenergy Research Center (DOE BER Office of Science) [DE-FC02-07ER64494, KP1601050]; US DOE Great Lakes Bioenergy Research Center (DOE EERE OBP) [20469-19145]; NASA [NNH12AU03I, NNH13ZDA001N] FX Funding for this work was provided by US EPA Biofuel Research Initiative, US DOE Great Lakes Bioenergy Research Center (DOE BER Office of Science DE-FC02-07ER64494, DOE BER Office of Science KP1601050, DOE EERE OBP 20469-19145), and NASA (NNH12AU03I and NNH13ZDA001N). We thank Ellen Cooter and Mark Johnson of the US EPA, and three anonymous reviewers, whose suggestions improved the quality of this manuscript. We also thank the USDA Farm Service Agency (FSA), particularly Rich Iovanna, for providing the CRP data. These data were obtained from the FSA under a Non-Disclosure Agreement (NDA 525277) signed with Battelle Memorial Institute, Pacific Northwest Division. Disclosure: The views expressed in this paper are those of the authors and do not necessarily represent the views or policies of the US Environmental Protection Agency. NR 49 TC 0 Z9 0 U1 2 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1757-1693 EI 1757-1707 J9 GCB BIOENERGY JI GCB Bioenergy PD FEB PY 2017 VL 9 IS 2 BP 460 EP 468 DI 10.1111/gcbb.12352 PG 9 WC Agronomy; Biotechnology & Applied Microbiology; Energy & Fuels SC Agriculture; Biotechnology & Applied Microbiology; Energy & Fuels GA EK0AV UT WOS:000393589600014 ER PT J AU Foster, MW Gwinn, WM Kelly, FL Brass, DM Valente, AM Moseley, MA Thompson, JW Morgan, DL Palmer, SM AF Foster, Matthew W. Gwinn, William M. Kelly, Francine L. Brass, David M. Valente, Ashlee M. Moseley, M. Arthur Thompson, J. Will Morgan, Daniel L. Palmer, Scott M. TI Proteomic Analysis of Primary Human Airway Epithelial Cells Exposed to the Respiratory Toxicant Diacetyl SO JOURNAL OF PROTEOME RESEARCH LA English DT Article DE BO; butter flavoring; butanedione; cornified envelope; pentanedione; repetin; RSPH4A; PRM; TGM1; squamous metaplasia ID BRONCHIOLITIS OBLITERANS; SQUAMOUS METAPLASIA; EPIDERMAL DIFFERENTIATION; INTERMEDIATE-FILAMENTS; TARGETED PROTEOMICS; FLAVORING AGENTS; II KERATINS; STEM-CELLS; PROTEIN; LUNG AB Occupational exposures to the diketone flavoring agent, diacetyl, have been associated with bronchiolitis obliterans, a rare condition of airway fibrosis. Model studies in rodents have suggested that the airway epithelium is a major site of diacetyl toxicity, but the effects of diacetyl exposure upon the human airway epithelium are poorly characterized. Here we performed quantitative LC-MS/MS-based proteomics to study the effects of repeated diacetyl vapor exposures on 3D organotypic cultures of human primary tracheobronchial epithelial cells. Using a label-free approach, we quantified approximately 3400 proteins and 5700 phosphopeptides in cell lysates across four independent donors. Altered expression of proteins and phosphopeptides were suggestive of loss of cilia and increased squamous differentiation in diacetyl-exposed cells. These phenomena were confirmed by immunofluorescence staining of culture cross sections. Hyperphosphorylation and cross-linking of basal cell keratin were also observed in diacetyltreated cells, and we used parallel reaction monitoring to confidently localize and quantify previously uncharacterized sites of phosphorylation in keratin 6. Collectively, these data identify numerous molecular changes in the epithelium that may be important to the pathogenesis of flavoring-induced bronchiolitis obliterans. More generally, this study highlights the utility of quantitative proteomics for the study of in vitro models of airway injury and disease. C1 [Foster, Matthew W.; Kelly, Francine L.; Brass, David M.; Valente, Ashlee M.; Palmer, Scott M.] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA. [Foster, Matthew W.; Moseley, M. Arthur; Thompson, J. Will] Duke Univ, Med Ctr, Duke Prote & Metabol Shared Resource, Durham, NC 27710 USA. [Gwinn, William M.; Morgan, Daniel L.] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC 27709 USA. RP Foster, MW (reprint author), Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA.; Foster, MW (reprint author), Duke Univ, Med Ctr, Duke Prote & Metabol Shared Resource, Durham, NC 27710 USA. EM mwfoster@duke.edu FU [R21 OH010490] FX This work was supported in part by R21 OH010490 (M.W.F. and S.M.P.) NR 51 TC 0 Z9 0 U1 5 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1535-3893 EI 1535-3907 J9 J PROTEOME RES JI J. Proteome Res. PD FEB PY 2017 VL 16 IS 2 BP 538 EP 549 DI 10.1021/acs.jproteome.6b00672 PG 12 WC Biochemical Research Methods SC Biochemistry & Molecular Biology GA EJ9IK UT WOS:000393539600017 PM 27966365 ER PT J AU Hall, KR Herbert, ME Sowa, SP Mysorekar, S Woznicki, SA Nejadhashemi, PA Wang, LZ AF Hall, Kimberly R. Herbert, Matthew E. Sowa, Scott P. Mysorekar, Sagar Woznicki, Sean A. Nejadhashemi, Pouyan A. Wang, Lizhu TI Reducing current and future risks: Using climate change scenarios to test an agricultural conservation framework SO JOURNAL OF GREAT LAKES RESEARCH LA English DT Article DE Climate adaptation; Climate change; Great lakes; Fish; Conservation outcomes; Agricultural impacts; Nutrient loading ID MIDWESTERN UNITED-STATES; RAINFALL EROSIVITY; IMPACTS; FISH; SOIL; ADAPTATION; MANAGEMENT; STRATEGIES; WISCONSIN; DROUGHT AB Evaluating the potential effects of changes in climate on conservation practices can help inform strategies to protect freshwater biodiversity that are robust, even as conditions change. Here we apply a climate change "test" to a framework for estimating the amount of agricultural conservation practices needed to achieve desired fish conservation outcomes for four watersheds in the Saginaw Bay region of Michigan, USA. We developed three climate scenarios from global climate model outputs (high emissions scenario, "2080s" timeframe) to provide insight on potential impacts of a climate driver that represents a key uncertainty for this management system, the amount and timing of spring and summer precipitation. These scenarios were used as inputs to agricultural watershed models, which produced water quality outputs that we compared to thresholds in fish biodiversity metrics at the subwatershed scale. Our results suggest that impacts of climate change on evaporation rates and other aspects of hydrology will shift the relative importance of key stressors for fish (i.e., sediment loadings vs. nutrient concentrations) across these different watersheds, highlighting the need to design resilient implementation plans and policies. Overall, we found that changes in climate are likely to increase the need for agricultural conservation practices, but that increasing the implementation rate above current levels will likely remain a good investment under current and future climate conditions. (C) 2016 International Association for Great Lakes Research. Published by Elsevier B.V. All rights reserved. C1 [Hall, Kimberly R.; Herbert, Matthew E.; Sowa, Scott P.; Mysorekar, Sagar] Nature Conservancy, 101 East Grand River Ave, Lansing, MI 48906 USA. [Woznicki, Sean A.; Nejadhashemi, Pouyan A.] Michigan State Univ, Dept Biosyst & Agr Engn, Farrall Agr Engn Halt 524 S Shaw Lane, E Lansing, MI 48824 USA. [Wang, Lizhu] Int Commiss, 100 Ouellette Ave,8th Floor, Windsor, ON N9A 6T3, Canada. [Woznicki, Sean A.] US EPA, Ecol & Human Community Anal Branch, Natl Exposure Res Lab, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. RP Hall, KR (reprint author), Nature Conservancy, 101 East Grand River Ave, Lansing, MI 48906 USA. EM kimberly.hall@tnc.org FU Wildlife component of the USDA NRCS Conservation Effects Assessment Project [68-7482-9-512, 68-7482-11-501]; Charles Stewart Mott Foundation; Herbert H. and Grace A. Dow Foundation; Kresge Foundation FX We thank the editors and two anonymous reviewers for helpful comments on this manuscript. We also thank Gust Annis for creating Fig. 1. Funding for the foundational components of this project was provided by the Wildlife component of the USDA NRCS Conservation Effects Assessment Project (Grant Agreements 68-7482-9-512 and 68-7482-11-501), the Charles Stewart Mott Foundation, and The Herbert H. and Grace A. Dow Foundation. Additional funding to address climate change was provided by Charles Stewart Mott Foundation and the Kresge Foundation. NR 54 TC 0 Z9 0 U1 8 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0380-1330 J9 J GREAT LAKES RES JI J. Gt. Lakes Res. PD FEB PY 2017 VL 43 IS 1 BP 59 EP 68 DI 10.1016/j.jglr.2016.11.005 PG 10 WC Environmental Sciences; Limnology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA EJ5JW UT WOS:000393255300006 ER PT J AU Angradi, TR Bartsch, WM Trebitz, AS Brady, VJ Launspach, JJ AF Angradi, Ted R. Bartsch, Will M. Trebitz, Anett S. Brady, Valerie J. Launspach, Jonathon J. TI A depth-adjusted ambient distribution approach for setting numeric removal targets for a Great Lakes Area of Concern beneficial use impairment: Degraded benthos SO JOURNAL OF GREAT LAKES RESEARCH LA English DT Article DE Great Lakes; St. Louis River; Benthos; Area of concern; Beneficial use impairment; Hexagenia ID WATER-QUALITY; HEXAGENIA-LIMBATA; SUPERIOR ESTUARY; ERIE; INVERTEBRATES; SEDIMENTS; RIVER; MACROINVERTEBRATES; EPHEMEROPTERA; EXPECTATIONS AB We compiled macroinvertebrate data collected from 1995 to 2014 from the St. Louis River Area of Concern (AOC) of Lake Superior. Our objective was to define depth-adjusted cutoff values for benthos condition classes to provide an analytical tool for quantifying progress toward achieving removal targets for the degraded benthos beneficial use impairment. We used quantile regression to model the limiting effect of depth on selected benthos metrics, including taxa richness, percent non-oligochaete individuals, combined percent Ephemeroptera, Trichoptera, and Odonata individuals, and density of ephemerid mayfly nymphs (Hexagenia). We created a scaled trimetric index from the first three metrics. Metric values above the 75th percentile quantile regression model prediction were defined as being in relatively excellent condition in the context of the degraded beneficial use impairment for that depth. We set the cutoff between good and fair condition as the 50th percentile model prediction, and we set the cutoff between fair and poor condition as the 25th percentile model prediction. We examined sampler type, geographic zone, and substrate type for confounding effects. Based on these analyses we combined data across sampler types and created separate models for each of three geographic zones. We used the resulting condition-class cutoff values to determine the relative benthic condition for three adjacent habitat restoration project areas. The depth-limited pattern of ephemerid abundance we observed in the St. Louis River AOC also occurred elsewhere in the Great Lakes. We provide tabulated model predictions for application of our depth-adjusted condition class cutoff values to new sample data. Published by Elsevier B.V. on behalf of International Association for Great Lakes Research. C1 [Angradi, Ted R.; Trebitz, Anett S.] US EPA, Off Res & Dev, Mid Continent Ecol Div, Natl Hlth & Environm Effects Res Lab, 6201 Congdon Blvd, Duluth, MN 55804 USA. [Bartsch, Will M.] Oak Ridge Inst Sci & Educ, 6201 Congdon Blvd, Duluth, MN 55804 USA. [Brady, Valerie J.] Univ Minnesota, Nat Resources Res Inst, 5013 Miller Trunk Highway, Duluth, MN 55811 USA. [Launspach, Jonathon J.] SRA Int Inc, 6201 Congdon Blvd, Duluth, MN 55804 USA. RP Angradi, TR (reprint author), US EPA, Off Res & Dev, Mid Continent Ecol Div, Natl Hlth & Environm Effects Res Lab, 6201 Congdon Blvd, Duluth, MN 55804 USA. EM angradi.theodore@epa.gov NR 57 TC 0 Z9 0 U1 4 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0380-1330 J9 J GREAT LAKES RES JI J. Gt. Lakes Res. PD FEB PY 2017 VL 43 IS 1 BP 108 EP 120 DI 10.1016/j.jglr.2016.11.006 PG 13 WC Environmental Sciences; Limnology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA EJ5JW UT WOS:000393255300011 ER PT J AU Peterson, GS Lietz, JE AF Peterson, Greg S. Lietz, Julie E. TI Identification of ruffe larvae (Gymnocephalus cernua) in the St. Louis River, Lake Superior: Clarification and guidance regarding morphological descriptions SO JOURNAL OF GREAT LAKES RESEARCH LA English DT Article DE Ruffe; Fish larvae; Identification; St Louis River; Great Lakes ID LIFE-HISTORY; FISHES; PRESERVATION; HABITAT; SYSTEM AB Non-native ruffe (Gymnocephalus cernua; family Percidae) were first detected in the Laurentian Great Lakes in 1986, and are not included in regional larval fish keys which were published several years prior to their discovery. In addition, subsequent scientific literature has inconsistently described ruffe larvae. As a result, identification of larval ruffe remains challenging. We used traditional morphology paired with DNA technology to develop diagnostics for ruffe larvae collected in the lower St. Louis River, and compared them to similar species. We found that ruffe <6 mm total length phenotypically resemble centrarchids, like black crappie, bluegill, and pumpkinseed, but have myomere counts that are intermediate between values for both common percid and centrarchid species. We suggest that developmental and pigment patterns as well as morphometrics can be used to distinguish ruffe from similar species at this size. At larger sizes, ruffe increasingly resemble other percids such as yellow perch, but can be distinguished using myomere counts and morphological features. The findings presented here clarify conflicting descriptions in the scientific literature, and provide additional data to support more confident morphological identification of larval ruffe. Published by Elsevier B.V. on behalf of International Association for Great Lakes Research. C1 [Peterson, Greg S.; Lietz, Julie E.] US EPA, Off Res & Dev, Mid Continent Ecol Div, Natl Hlth & Environm Effects Res Lab, 6201 Congdon Blvd, Duluth, MN 55804 USA. [Lietz, Julie E.] ORISE Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. RP Peterson, GS (reprint author), 6201 Congdon Blvd, Duluth, MN 55804 USA. EM peterson.greg@epa.gov; JElizBarker@gmail.com FU EPA [IA 92298301]; DOA [IA 92298301] FX We thank scientists at the U.S. EPA Office of Research and Development, Mid-continent Ecology Division (Duluth)-specifically, Joel Hoffman and Anett Trebitz for offering advisement, review comments, and fieldwork support. In addition, Tim Corry, Sam Miller, Jill Scharold, Anne Cotter, Will Bartsch (ORISE), Tyler Billehus, Chelsea Hatzenbuhler (ORISE), Shane Zavodnik, Zach Polaske (Badger Technical Services), Hannah Coe (GRO Intern), George Grant (GRO Intern), and Mikayla Haynes (Volunteer), were all involved in aspects of sample collection and processing. We thank EPA's Ecosystem Integrity Branch (EIB) and Internal Exposure Indicator Branch (IEIB), National Exposure Research Laboratory (Cincinnati), specifically Erik Pilgrim (EIB), John Martinson (IEIB), and Sara Okum (EIB, ORISE) for the work to complete the larval fish DNA-based identification. Julie Lietz prepared all illustrations. Thanks to David Jude and JGLR anonymous reviewers for constructive comments. Julie Lietz was an ORISE participant at EPA, during which she helped conduct this research. This work was supported in part by an appointment to the ORISE participant research program supported by an interagency agreement between EPA and DOA (IA 92298301); views expressed in this paper are those of the authors and do not necessarily reflect the view or policies of the U.S. EPA. NR 34 TC 0 Z9 0 U1 2 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0380-1330 J9 J GREAT LAKES RES JI J. Gt. Lakes Res. PD FEB PY 2017 VL 43 IS 1 BP 205 EP 210 DI 10.1016/j.jiglr.2016.10.005 PG 6 WC Environmental Sciences; Limnology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA EJ5JW UT WOS:000393255300021 ER PT J AU Shaw, ND Brand, H Kupchinsky, ZA Bengani, H Plummer, L Jones, TI Erdin, S Williamson, KA Rainger, J Stortchevoi, A Samocha, K Curra, BB Dunican, DS Collins, RL Willer, JR Lek, A Lek, M Nassan, M Pereira, S Kammin, T Lucente, D Silva, A Seabra, CM Chiang, C Ana, Y Ansari, M Rainger, JK Joss, S Smith, JC Lippincott, MF Singh, SS Patel, N Jing, JW Law, JR Ferraro, N Verloes, M Rauch, A Steindl, K Zweier, M Scheer, I Sato, D Okamoto, N Jacobsen, C Tryggestad, J Chernausek, S Schimmenti, LA Brasseur, B Cesaretti, C Garcia-Ortiz, JE Buitrago, TP Silva, OP Hoffman, JD Muhlbauer, W Ruprecht, KW Loeys, BL Shino, M Kaind, AM Cho, CH Morton, CC Meehan, RR van Heyningen, V Liao, EC Balasubramanian, R Hall, JE Seminara, SB Macarthur, D Moore, SA Yoshiura, K Gusella, JF Marsh, JA Graham, JM Lin, AE Katsanis, N Jones, PL Crowley, WF Davis, EE FitzPatrick, DR Talkowski, ME AF Shaw, Natalie D. Brand, Harrison Kupchinsky, Zachary A. Bengani, Hemant Plummer, Lacey Jones, Takako I. Erdin, Serkan Williamson, Kathleen A. Rainger, Joe Stortchevoi, Alexei Samocha, Kaitlin Curra, Benjamin B. Dunican, Donncha S. Collins, Ryan L. Willer, Jason R. Lek, Angela Lek, Monkol Nassan, Malik Pereira, Shahrin Kammin, Tammy Lucente, Diane Silva, Alexandra Seabra, Catarina M. Chiang, Colby Ana, Yu Ansari, Morad Rainger, Jacqueline K. Joss, Shelagh Smith, Jill Clayton Lippincott, Margaret F. Singh, Sylvia S. Patel, Nirav Jing, Jenny W. Law, Jennifer R. Ferraro, Nalton Verloes, Main Rauch, Anita Steindl, Katharina Zweier, Markus Scheer, Ianina Sato, Daisuke Okamoto, Nobuhiko Jacobsen, Christina Tryggestad, Jeanie Chernausek, Steven Schimmenti, Lisa A. Brasseur, Benjamin Cesaretti, Claudia Garcia-Ortiz, Jose E. Pineda Buitrago, Tatiana Perez Silva, Orlando Hoffman, Jodi D. Muehlbauer, Wolfgang Ruprecht, Klaus W. Loeys, Bart L. Shino, Masato Kaind, Angela M. Cho, Chie-Hee Morton, Cynthia C. Meehan, Richard R. van Heyningen, Veronica Liao, Eric C. Balasubramanian, Ravikumar Hall, Janet E. Seminara, Stephanie B. Macarthur, Daniel Moore, Steven A. Yoshiura, Koh-ichiro Gusella, James F. Marsh, Joseph A. Graham, John M., Jr. Lin, Angela E. Katsanis, Nicholas Jones, Peter L. Crowley, William F., Jr. Davis, Erica E. FitzPatrick, David R. Talkowski, Michael E. TI SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome SO NATURE GENETICS LA English DT Article ID X INACTIVATION; CHROMOSOME; EXPRESSION; DOMAIN; FSHD1; GNRH; METHYLATION; INHERITANCE; HYPOPLASIA; PREDICTION AB Arhinia, or absence of the nose, is a rare malformation of unknown etiology that is often accompanied by ocular and reproductive defects. Sequencing of 40 people with arhinia revealed that 84% of probands harbor a missense mutation localized to a constrained region of SMCHD1 encompassing the ATPase domain. SMCHD1 mutations cause facioscapulohumeral muscular dystrophy type 2 (FSHD2) via a trans-acting loss-of function epigenetic mechanism. We discovered shared mutations and comparable DNA hypomethylation patterning between these distinct disorders. CRISPR/Cas9-mediated alteration of smchd1 in zebrafish yielded arhinia-relevant phenotypes. Transcriptome and protein analyses in arhinia probands and controls showed no differences in SMCHD1 mRNA or protein abundance but revealed regulatory changes in genes and pathways associated with craniofacial patterning. Mutations in SMCHD1 thus contribute to distinct phenotypic spectra, from craniofacial malformation and reproductive disorders to muscular dystrophy, which we speculate to be consistent with oligogenic mechanisms resulting in pleiotropic outcomes. C1 [Shaw, Natalie D.; Brand, Harrison; Plummer, Lacey; Lippincott, Margaret F.; Singh, Sylvia S.; Patel, Nirav; Jing, Jenny W.; Balasubramanian, Ravikumar; Hall, Janet E.; Seminara, Stephanie B.; Crowley, William F., Jr.] Massachusetts Gen Hosp, Dept Med, Reprod Endocrine Unit, Harvard Reprod Endocrine Sci Ctr, Boston, MA 02114 USA. [Shaw, Natalie D.; Brand, Harrison; Plummer, Lacey; Lippincott, Margaret F.; Singh, Sylvia S.; Patel, Nirav; Jing, Jenny W.; Balasubramanian, Ravikumar; Hall, Janet E.; Seminara, Stephanie B.; Crowley, William F., Jr.] Massachusetts Gen Hosp, Dept Med, Reprod Endocrine Unit, NICHD Ctr Excellence Translat Res Fertil & Infert, Boston, MA 02114 USA. [Shaw, Natalie D.; Hall, Janet E.] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA. [Brand, Harrison; Erdin, Serkan; Stortchevoi, Alexei; Curra, Benjamin B.; Collins, Ryan L.; Lucente, Diane; Silva, Alexandra; Seabra, Catarina M.; Chiang, Colby; Ana, Yu; Talkowski, Michael E.] Massachusetts Gen Hosp, Ctr Human Genet Res, Mol Neurogenet Unit, Boston, MA 02114 USA. [Brand, Harrison; Erdin, Serkan; Stortchevoi, Alexei; Curra, Benjamin B.; Collins, Ryan L.; Lucente, Diane; Silva, Alexandra; Seabra, Catarina M.; Chiang, Colby; Ana, Yu; Gusella, James F.; Talkowski, Michael E.] Massachusetts Gen Hosp, Ctr Human Genet Res, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA. [Brand, Harrison; Gusella, James F.; Talkowski, Michael E.] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA. [Brand, Harrison; Samocha, Kaitlin; Lek, Monkol; Jacobsen, Christina; Liao, Eric C.; Lin, Angela E.; Talkowski, Michael E.] Harvard Med Sch, Boston, MA 02115 USA. [Brand, Harrison; Erdin, Serkan; Samocha, Kaitlin; Lek, Monkol; Morton, Cynthia C.; Macarthur, Daniel; Gusella, James F.; Talkowski, Michael E.] Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA 02142 USA. [Kupchinsky, Zachary A.; Willer, Jason R.; Katsanis, Nicholas; Davis, Erica E.] Duke Univ, Med Ctr, Ctr Human Dis Modeling, Durham, NC 27708 USA. [Bengani, Hemant; Williamson, Kathleen A.; Rainger, Joe; Dunican, Donncha S.; Ansari, Morad; Rainger, Jacqueline K.; Meehan, Richard R.; van Heyningen, Veronica; Marsh, Joseph A.; FitzPatrick, David R.] Univ Edinburgh, Western Gen Hosp, Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland. [Jones, Takako I.; Jones, Peter L.] Univ Massachusetts Med Sch, Dept Cell & Dev Biol, Worcester, MA 01655 USA. [Samocha, Kaitlin; Lek, Monkol; Macarthur, Daniel] Massachusetts Gen Hosp, Dept Med, Analyt & Translat Genet Unit, Boston, MA 02114 USA. [Collins, Ryan L.] Harvard Med Sch, Div Med Sci, Program Bioinformat & Integrat Genom, Boston, MA 02115 USA. [Lek, Angela; Gusella, James F.] Harvard Med Sch, Dept Genet, Boston, MA 02115 USA. [Nassan, Malik] Mayo Clin, Dept Psychiat & Psychol, Rochester, MN 55905 USA. [Pereira, Shahrin; Kammin, Tammy; Morton, Cynthia C.] Brigham & Womens Hosp, Dept Obstet Gynecol & Reprod Biol, 75 Francis St, Boston, MA 02115 USA. [Seabra, Catarina M.] Univ Porto, GABBA Program, Oporto, Portugal. [Joss, Shelagh] South Glasgow Univ Hosp, West Scotland Genet Serv, Glasgow, Lanark, Scotland. [Smith, Jill Clayton] Univ Manchester, Manchester Acad Hlth Sci Ctr, Manchester Ctr Genom Med, Fac Med & Human Sci,Inst Human Dev, Manchester, Lancs, England. [Law, Jennifer R.] Univ N Carolina, Div Pediat Endocrinol, Chapel Hill, NC 27514 USA. [Ferraro, Nalton] Boston Childrens Hosp, Dept Oral & Maxillofacial Surg, Boston, MA USA. [Verloes, Main] Robert Debre Hosp, Dept Genet, Paris, France. [Rauch, Anita; Steindl, Katharina; Zweier, Markus] Univ Zurich, Clin Res Prior Program Rare Dis, Inst Med Genet, Schlieren, Switzerland. [Rauch, Anita; Steindl, Katharina; Zweier, Markus] Univ Zurich, Clin Res Prior Program Rare Dis, Radiz Rare Dis Initiat Zurich, Schlieren, Switzerland. [Scheer, Ianina] Childrens Hosp, Dept Diagnost Imaging, Zurich, Switzerland. [Sato, Daisuke] Hokkaido Univ, Grad Sch Med, Dept Pediat, Sapporo, Hokkaido, Japan. [Okamoto, Nobuhiko] Osaka Med Ctr, Dept Med Genet, Osaka, Japan. [Okamoto, Nobuhiko] Res Inst Maternal & Child Hlth, Osaka, Japan. [Jacobsen, Christina] Boston Childrens Hosp, Div Endocrinol & Genet, Boston, MA 02115 USA. [Tryggestad, Jeanie] Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, Oklahoma City, OK 73190 USA. [Schimmenti, Lisa A.] Mayo Clin, Dept Otorhinolaryngol, Rochester, MN 55905 USA. [Schimmenti, Lisa A.] Mayo Clin, Dep Clin Genom, Rochester, MN 55905 USA. [Brasseur, Benjamin] Univ Miami, Leonard M Miller Sch Med, DeWitt Daughtry Family Dept Surg, Miami, FL 33146 USA. [Cesaretti, Claudia] Osped Maggiore Policlin, Fdn IRCCS Ca Granda, Med Genet Unit, Milan, Italy. [Garcia-Ortiz, Jose E.] Inst Mexicano Seguro Social, Ctr Invest Biomed Occidente, Div Genet, Guadalajara, Mexico. [Pineda Buitrago, Tatiana] San Jose State Univ, Fdn Hosp Infantil, Bogota, Colombia. [Perez Silva, Orlando] Acad Nacl Med Colombia, Bogota, Colombia. [Hoffman, Jodi D.] Tufts Med Ctr, Div Genet, Boston, MA 02111 USA. [Hoffman, Jodi D.] Tufts Med Ctr, Div Maternal Fetal Med, Boston, MA 02111 USA. [Muehlbauer, Wolfgang] ATOS Klin, Dept Plast & Aesthet Surg, Munich, Germany. [Ruprecht, Klaus W.] Univ Hosp Saarland, Dept Ophthalmol, Homburg, Germany. [Loeys, Bart L.] Univ Antwerp, Ctr Med Genet, Antwerp, Belgium. [Loeys, Bart L.] Univ Antwerp Hosp, Antwerp, Belgium. [Shino, Masato] Gunma Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Gunma, Japan. [Kaind, Angela M.] Charite, Biol & Neurobiol, Berlin, Germany. [Kaind, Angela M.] Berlin Inst Hlth, Berlin, Germany. [Cho, Chie-Hee] Univ Hosp Bern, Inselspital, Dept Diagnost Intervent & Pediat Radiol, Bern, Switzerland. [Liao, Eric C.] Massachusetts Gen Hosp, Ctr Regenerat Med, Boston, MA 02114 USA. [Liao, Eric C.] Massachusetts Gen Hosp, Div Plast & Reconstruct Surg, Boston, MA 02114 USA. [Liao, Eric C.] Harvard Stem Cell Inst, Cambridge, MA 02138 USA. [Macarthur, Daniel; Talkowski, Michael E.] Broad Inst MIT & Harvard, Ctr Mendelian Genom, Cambridge, MA 02142 USA. [Moore, Steven A.] Univ Iowa, Carver Coll Med, Dept Pathol, Iowa City, IA 52242 USA. [Yoshiura, Koh-ichiro] Nagasaki Univ, Grad Sch Biomed Sci, Dept Human Genet, Nagasaki, Japan. [Graham, John M., Jr.] Cedars Sinai Med Ctr, Dept Pediat, Los Angeles, CA 90048 USA. [Lin, Angela E.] MassGeneral Hosp Children, Med Genet, Boston, MA 02114 USA. RP Talkowski, ME (reprint author), Massachusetts Gen Hosp, Ctr Human Genet Res, Mol Neurogenet Unit, Boston, MA 02114 USA.; Talkowski, ME (reprint author), Massachusetts Gen Hosp, Ctr Human Genet Res, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA.; Talkowski, ME (reprint author), Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA.; Talkowski, ME (reprint author), Harvard Med Sch, Boston, MA 02115 USA.; Talkowski, ME (reprint author), Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA 02142 USA.; Davis, EE (reprint author), Duke Univ, Med Ctr, Ctr Human Dis Modeling, Durham, NC 27708 USA.; FitzPatrick, DR (reprint author), Univ Edinburgh, Western Gen Hosp, Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland.; Talkowski, ME (reprint author), Broad Inst MIT & Harvard, Ctr Mendelian Genom, Cambridge, MA 02142 USA. EM erica.davis@duke.edu; david.fitzpatrick@igmm.ed.ac.uk; talkowski@chgr.mgh.harvard.edu OI van Heyningen, Veronica/0000-0003-0359-0141; Erdin, Serkan/0000-0001-6587-2625; Shaw, Natalie/0000-0002-0847-9170; Loeys, Bart/0000-0003-3703-9518; Hall, Janet/0000-0003-4644-3061; FitzPatrick, David R./0000-0003-4861-969X; Marsh, Joseph/0000-0003-4132-0628 FU National Institutes of Health ((NIH)) [R00MH095867, R01HD081256, P01GM061354, T32HD007396, P50HD028138]; MGH Robert and Laura Reynolds Research Scholar Award [R01HD043341]; March of Dimes [FY15-255]; Medical Research Council [MR/M02122X/1]; German Research Foundation [SFB665]; Berlin Institute of Health (BIH) [CRG1]; Medical Research Council (MRC) Human Genetics Unit award [MC_PC_U127574433]; University of Edinburgh Institute of Genomics and Molecular Medicine Translational Initiative Fund; [K23HD073304-02]; [1SI2ES025429-01]; [P50DK096415]; [R01AR062587]; [U54-NS053672] FX We thank all participants, family members and clinical staff for their generous contributions of time and materials to this research. We thank T. Gillis, J. Ruliera, C. Hanscom, C. Antolik and M. Anderson for technical assistance. This project was funded by grants from the National Institutes of Health ((NIH) R00MH095867 and R01HD081256 to M.E.T.; P01GM061354 to M.E.T., J.F.G., C.C.M. and E.C.L.; T32HD007396 to H. Brand; P50HD028138 to W.F.C., S.B.S., M.E.T., N.K. and E.E.D.; R01HD043341 and MGH Robert and Laura Reynolds Research Scholar Award to S.B.S.; K23HD073304-02 and 1SI2ES025429-01 to N.D.S.; P50DK096415 to N.K. and R01AR062587 to P.L.J.); the March of Dimes (FY15-255 to M.E.T.); the Medical Research Council (MR/M02122X/1 to J.A.M.); the German Research Foundation (SFB665 to A.M.K.) and the Berlin Institute of Health (BIH-CRG1 to A.M.K.). D.R.F., R.R.M. (MC_PC_U127574433), D.S.D., H. Bengani, K.A.W., J.R., J.K.R. and J.A.M. are funded by program grants from the Medical Research Council (MRC) Human Genetics Unit award to the University of Edinburgh. M.A. is funded by the University of Edinburgh Institute of Genomics and Molecular Medicine Translational Initiative Fund. S.A.M. is supported by U54-NS053672, which funds the Iowa, Paul D. Wellstone Muscular Dystrophy Cooperative Research Center. N.K. is supported as a Distinguished Jean and George Brumley Professor at Duke University, and M.E.T. is supported as the Desmond and Ann Heathwood MGH Research Scholar. NR 52 TC 1 Z9 1 U1 2 U2 2 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1061-4036 EI 1546-1718 J9 NAT GENET JI Nature Genet. PD FEB PY 2017 VL 49 IS 2 BP 238 EP 248 DI 10.1038/ng.3743 PG 11 WC Genetics & Heredity SC Genetics & Heredity GA EJ3YM UT WOS:000393148600012 PM 28067909 ER PT J AU Schoen, ME Xue, XB Wood, A Hawkins, TR Garland, J Ashbolt, NJ AF Schoen, Mary E. Xue, Xiaobo Wood, Alison Hawkins, Troy R. Garland, Jay Ashbolt, Nicholas J. TI Cost, energy, global warming, eutrophication and local human health impacts of community water and sanitation service options SO WATER RESEARCH LA English DT Article DE Sustainability; Water; Wastewater; LCA; QMRA ID LIFE-CYCLE ASSESSMENT; SUSTAINABILITY ASSESSMENT; RISK-ASSESSMENT; TRADE-OFF; MANAGEMENT; AID; SYSTEMS; BURDEN AB We compared water and sanitation system options for a coastal community across selected sustainability metrics, including environmental impact (i.e., life cycle eutrophication potential, energy consumption, and global warming potential), equivalent annual cost, and local human health impact. We computed normalized metric scores, which we used to discuss the options' strengths and weaknesses, and conducted sensitivity analysis of the scores to changes in variable and uncertain input parameters. The alternative systems, which combined centralized drinking water with sanitation services based on the concepts of energy and nutrient recovery as well as on-site water reuse, had reduced environmental and local human health impacts and costs than the conventional, centralized option. Of the selected sustainability metrics, the greatest advantages of the alternative community water systems (compared to the conventional system) were in terms of local human health impact and eutrophication potential, despite large, outstanding uncertainties. Of the alternative options, the systems with on-site water reuse and energy recovery technologies had the least local human health impact; however, the cost of these options was highly variable and the energy consumption was comparable to on-site alternatives without water reuse or energy recovery, due to on-site reuse treatment. Future work should aim to reduce the uncertainty in the energy recovery process and explore the health risks associated with less costly, on site water treatment options. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Schoen, Mary E.] Soller Environm Inc, 3022 King St, Berkeley, CA 94703 USA. [Xue, Xiaobo] SUNY Albany, Sch Publ Hlth, Dept Environm Hlth Sci, 1 Univ Pl, Rensselaer, NY 12144 USA. [Wood, Alison] Univ Texas Austin, Dept Civil Architectural & Environm Engn, 301 E Dean Keeton St C8600, Austin, TX 78712 USA. [Hawkins, Troy R.] Franklin Associates, Div A, Eastern Res Grp, 110 Hartwell Ave, Lexington, MA 02421 USA. [Garland, Jay] US EPA, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. [Ashbolt, Nicholas J.] Univ Alberta, Sch Publ Hlth, Rm 3-57D South Acad Bldg, Edmonton, AB T6G 2G7, Canada. RP Schoen, ME (reprint author), Soller Environm Inc, 3022 King St, Berkeley, CA 94703 USA. EM mschoen@sollerenvironmental.com; xxue@albany.edu; alisonwood@gmail.com; troy.hawkins@erg.com; Garland.jay@epa.gov; ashbolt@ualberta.ca FU U.S. Environmental Protection Agency Office of Research and Development FX This project was supported by the U.S. Environmental Protection Agency Office of Research and Development. NR 34 TC 0 Z9 0 U1 18 U2 18 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0043-1354 J9 WATER RES JI Water Res. PD FEB 1 PY 2017 VL 109 BP 186 EP 195 DI 10.1016/j.watres.2016.11.044 PG 10 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA EI8WM UT WOS:000392788900019 PM 27888775 ER PT J AU Beck, SE Ryu, H Boczek, LA Cashdollar, JL Jeanis, KM Rosenblum, JS Lawal, OR Linden, KG AF Beck, Sara E. Ryu, Hodon Boczek, Laura A. Cashdollar, Jennifer L. Jeanis, Kaitlyn M. Rosenblum, James S. Lawal, Oliver R. Linden, Karl G. TI Evaluating UV-C LED disinfection performance and investigating potential dual-wavelength synergy SO WATER RESEARCH LA English DT Article DE Combined wavelengths; Electrical energy per order; Human adenovirus type 2; Bacillus pumilus spores; Nucleic acid damage ID LIGHT-EMITTING-DIODES; USE WATER DISINFECTION; ULTRAVIOLET LIGHT; BACILLUS-SUBTILIS; INACTIVATION; VIRUSES; ADENOVIRUSES; SENSITIVITY; VALIDATION; EFFICIENCY AB A dual-wavelength UV-C LED Unit, emitting at peaks of 260 rim, 280 nm, and the combination of 2601280 nm together was evaluated for its inactivation efficacy and energy efficiency at disinfecting Escherichia coli, MS2 coliphage, human adenovirus type 2 (HAdV2), and Bacillus pumilus spores, compared to conventional low-pressure and medium-pressure UV mercury vapor lamps. The dual wavelength unit was also used to measure potential synergistic effects of multiple wavelengths on bacterial and viral inactivation and DNA and RNA damage. All five UV sources demonstrated similar inactivation of E. coli. For MS2, the 260 nm LED was most effective. For HAdV2 and B. pumilus, the MP UV lamp was most effective. When measuring electrical energy per order of reduction, the LP UV lamp was most efficient for inactivating E. coli and MS2; the LP UV and MP UV mercury lamps were equally efficient for HAdV2 and B. pumilus spores. Among the UV-C LEDs, there was no statistical difference in electrical efficiency for inactivating MS2, HAdV2, and B. pumilus spores. The 260 nm and 2601280 nm LEDs had a statistical energy advantage for E. coli inactivation. For UV-C LEDs to match the electrical efficiency per order of log reduction of conventional LP UV sources, they must reach efficiencies of 25-39% or be improved on by smart reactor design. No dual wavelength synergies were detected for bacterial and viral inactivation nor for DNA and RNA damage. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Beck, Sara E.; Jeanis, Kaitlyn M.; Rosenblum, James S.; Linden, Karl G.] Univ Colorado Boulder, Dept Civil Environm & Architectural Engn, Boulder, CO 80309 USA. [Ryu, Hodon; Boczek, Laura A.; Cashdollar, Jennifer L.] US EPA, Off Res & Dev, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. [Lawal, Oliver R.] AquiSense Technol, 11941 Oxford Hills Dr, Walton, KY 41094 USA. [Beck, Sara E.] Asian Inst Technol, Sch Environm Resources & Dev, Pathum Thani 12120, Thailand. RP Linden, KG (reprint author), Univ Colorado Boulder, Dept Civil Environm & Architectural Engn, Boulder, CO 80309 USA. EM karl.linden@colorado.edu OI Linden, Karl G./0000-0003-4301-7227 FU U.S. EPA [FP91709801] FX The U.S. Environmental Protection Agency (EPA), through its Office of Research and Development, partially funded and managed the research described herein. S. Beck was partially supported by the U.S. EPA Fellowship Assistance Agreement FP91709801. This work has been subjected to the agency's administrative review and has been approved for external publication. Any opinions expressed do not reflect the views of the agency; therefore, no official endorsement should be inferred. Any mention of trade names or commercial products does not constitute endorsement or recommendation for use. We thank Emma Huff, Jill Hoelle, and Dr. Jennifer Pagan for technical assistance. We also appreciate Jeff Adams and Dr. Nichole Brinkman for their critical review of the manuscript. NR 47 TC 1 Z9 1 U1 8 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0043-1354 J9 WATER RES JI Water Res. PD FEB 1 PY 2017 VL 109 BP 207 EP 216 DI 10.1016/j.watres.2016.11.024 PG 10 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA EI8WM UT WOS:000392788900021 PM 27889622 ER PT J AU Aurell, J Gullett, BK Tabor, D Yonker, N AF Aurell, Johanna Gullett, Brian K. Tabor, Dennis Yonker, Nick TI Emissions from prescribed burning of timber slash piles in Oregon SO ATMOSPHERIC ENVIRONMENT LA English DT Article DE Emission factors; Timber slash; Pile cover; Moisture; Polyethylene; Biomass burning ID BIOMASS; AERIAL; FIELD AB Emissions from burning piles of post-harvest timber slash (Douglas-fir) in Grande Ronde, Oregon were sampled using an instrument platform lofted into the plume using a tether-controlled aerostat or balloon. Emissions of carbon monoxide, carbon dioxide, methane, particulate matter (PM2.5), black carbon, ultraviolet absorbing PM, elemental/organic carbon, filter-based metals, polycyclic aromatic hydrocarbons (PAHs), polychlorinated dibenzodioxins/dibenzofurans (PCDD/PCDF), and volatile organic compounds (VOCs) were sampled to determine emission factors, the amount of pollutant formed per amount of biomass burned. The effect on emissions from covering the piles with polyethylene (PE) sheets to prevent fuel wetting versus uncovered piles was also determined. Results showed that the uncovered ("wet") piles burned with lower combustion efficiency and higher emission factors for VOCs, PM2.5, PCDD/PCDF, and PAHs. Removal of the PE prior to ignition, variation of PE size, and changing PE thickness resulted in no statistical distinction between emissions. Results suggest that dry piles, whether covered with PE or not, exhibited statistically significant lower emissions than wet piles due to better combustion efficiency. Published by Elsevier Ltd. C1 [Aurell, Johanna] Univ Dayton, Res Inst, 300 Coll Pk, Dayton, OH 45469 USA. [Gullett, Brian K.; Tabor, Dennis] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. [Yonker, Nick] Oregon Dept Forestry Fire Protect, 2600 State St, Salem, OR 97310 USA. RP Gullett, BK (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. EM aurell.johanna@epa.gov; gullett.brian@epa.gov; tabor.dennis@epa.gov; Nick.J.Yonker@oregon.gov FU Oregon Department of Forestry; U.S. EPA Office of Research and Development [868-15] FX The authors appreciate the site access and cooperation of Jerry Anderson, the test site manager for Hancock Timber Resources. Jeff Classen and Gail Culbertson, both of the Dallas Unit of Western Oregon ODF District, provided fire duties, transportation, and logistical support. Sean Riordan and Paul Davies (ATA Aerospace) along with Tracy Gerber, US Air Force Research Laboratory (Kirtland AFB) provided aerostat flight operations. Sue MacMillan, Brian Finneran, and Anthony Barnack of the Oregon Department of Environmental Quality provided technical support on toxics and emissions. David Weise (Pacific SW Research Station), Roger Ottmar (Pacific NW Research Station), Shawn Urbanski (Missoula Fire Laboratory), and Harold Merritt (Plum Creek Timber) provided technical support. This work was funded by the Oregon Department of Forestry and the U.S. EPA Office of Research and Development through a Cooperative Research and Development Agreement, #868-15. NR 31 TC 0 Z9 0 U1 6 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 EI 1873-2844 J9 ATMOS ENVIRON JI Atmos. Environ. PD FEB PY 2017 VL 150 BP 395 EP 406 DI 10.1016/j.atmosenv.2016.11.034 PG 12 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA EI8PU UT WOS:000392770700038 ER PT J AU Schroeder, AL Martinovic-Weigelt, D Ankley, GT Lee, KE Garcia-Reyero, N Perkins, EJ Schoenfuss, HL Villeneuve, DL AF Schroeder, Anthony L. Martinovic-Weigelt, Dalrrla Ankley, Gerald T. Lee, Kathy E. Garcia-Reyero, Natalia Perkins, Edward J. Schoenfuss, Heiko L. Villeneuve, Daniel L. TI Prior knowledge-based approach for associating contaminants with biological effects: A case study in the St. Croix River basin, MN, WI, USA SO ENVIRONMENTAL POLLUTION LA English DT Article DE Contaminants; Chemical mixtures; Chemical-gene interactions; Comparative toxicogenomics database; Adverse outcome pathway ID MINNOWS PIMEPHALES-PROMELAS; HIGH-THROUGHPUT DATA; FATHEAD MINNOWS; GENE-EXPRESSION; WASTE-WATER; ORGANIC MICROPOLLUTANTS; IN-VITRO; MANAGEMENT; MINNESOTA; CHEMICALS AB Evaluating potential adverse effects of complex chemical mixtures in the environment is challenging. One way to address that challenge is through more integrated analysis of chemical monitoring and biological effects data. In the present study, water samples from five locations near two municipal wastewater treatment plants in the St. Croix River basin, on the border of MN and WI, USA, were analyzed for 127 organic contaminants. Known chemical-gene interactions were used to develop site specific knowledge assembly models (KAMs) and formulate hypotheses concerning possible biological effects associated with chemicals detected in water samples from each location. Additionally, hepatic gene expression data were collected for fathead minnows (Pimephales promelas) exposed in situ, for 12 d, at each location. Expression data from oligonucleotide microarrays were analyzed to identify functional annotation terms enriched among the differentially-expressed probes. The general nature of many of the terms made hypothesis formulation on the basis of the transcriptome-level response alone difficult. However, integrated analysis of the transcriptome data in the context of the site-specific KAMs allowed for evaluation of the likelihood of specific chemicals contributing to observed biological responses. Thirteen chemicals (atrazine, carbamazepine, metformin, thiabendazole, diazepam, cholesterol, p-cresol, phenytoin, omeprazole, ethyromycin, 17 beta-estradiol, cimetidine, and estrone), for which there was statistically significant concordance between occurrence at a site and expected biological response as represented in the KAM, were identified. While not definitive, the approach provides a line of evidence for evaluating potential cause-effect relationships between components of a complex mixture of contaminants and biological effects data, which can inform subsequent monitoring and investigation. Published by Elsevier Ltd. C1 [Schroeder, Anthony L.] Univ Minnesota Twin Cities, Water Resources Ctr, 1985 Lower Buford Circle, St Paul, MN 55108 USA. [Schroeder, Anthony L.; Ankley, Gerald T.; Villeneuve, Daniel L.] US EPA, Natl Hlth & Environm Effects Res Lab, Duluth, MN 55804 USA. [Martinovic-Weigelt, Dalrrla] Univ St Thomas, Dept Biol, Mail OWS 390,2115 Summit Ave, St Paul, MN 55105 USA. [Lee, Kathy E.] US Geol Survey, Tox Subst Hydrol Program, Grand Rapids, MN 55744 USA. [Garcia-Reyero, Natalia; Perkins, Edward J.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS 39762 USA. [Schoenfuss, Heiko L.] Cloud State Univ, Aquat Toxicol Lab, WSB 273, St Cloud, MN 56301 USA. RP Villeneuve, DL (reprint author), US EPA, Midcontinent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA. EM Villeneuve.dan@epa.gov OI Schoenfuss, Heiko/0000-0001-5464-992X FU USGS; National Science Foundation [CBET-1336062/1336165/1336604]; National Park Service Water Quality Partnership Program, US EPA (Office of Research and Development's Chemical Safety for Sustainability Research Program); National Park Service Water Quality Partnership Program, US EPA (Region 5, Great Lakes National Program Office) FX Support by the USGS and National Park Service Water Quality Partnership Program, US EPA (Office of Research and Development's Chemical Safety for Sustainability Research Program, and Region 5, Great Lakes National Program Office), and National Science Foundation (CBET-1336062/1336165/1336604 to DM-W). We thank Sarah Elliott, Jeffery Ziegeweid, and Brent Mason at USGS for their field support; and Byron Karns at NPS for logistical support. We thank Maya Peters, Jackie Heitzman, Abigail Lukowicz, Evan Eid, Kyle Stevens, Jenna Cavallin, Megan Hughes, Krysta Nelson, Rebecca Milsk, Travis Saari, and Eric Randolph for help with network development. We thank Lynn Escalon for microarray analysis. Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U.S. Government. The contents neither constitute, nor necessarily reflect, US EPA policy. Permission was granted by the Chief of Engineers to publish this information. NR 40 TC 0 Z9 0 U1 13 U2 13 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0269-7491 EI 1873-6424 J9 ENVIRON POLLUT JI Environ. Pollut. PD FEB PY 2017 VL 221 BP 427 EP 436 DI 10.1016/j.envpol.2016.12.005 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA EI8OV UT WOS:000392767900045 PM 27939634 ER PT J AU Tolaymat, T El Badawy, A Genaidy, A Abdelraheem, W Sequeira, R AF Tolaymat, Thabet El Badawy, Amro Genaidy, Ash Abdelraheem, Wael Sequeira, Reynold TI Analysis of metallic and metal oxide nanomaterial environmental emissions SO JOURNAL OF CLEANER PRODUCTION LA English DT Article DE Emission; Engineered nanomaterials; Physical-chemical properties; Environment ID EVIDENCE-BASED MEDICINE; WASTE-WATER TREATMENT; SILVER NANOPARTICLES; ENGINEERED NANOMATERIALS; TITANIUM-DIOXIDE; ESCHERICHIA-COLI; SURFACE-CHARGE; MANUFACTURED NANOPARTICLES; ANTIBACTERIAL ACTIVITY; EXPOSURE ASSESSMENT AB The current study presents evidence on metallic and metal oxide engineered nanomaterial (ENM) emissions into the environment and an analytic perspective of the outcomes of evaluated studies with respect to different individual end points along the lifecycle trajectory. The key findings suggest that 1) the published literature on emissions of metallic ENMs is limited in both the number and information available on the characteristics of emitted ENMs; 2) the studies are classified as experimental and computational studies focused on predicting ENM emissions; 3) the majority of studies investigated ENM emissions during nanomaterial use and waste management, followed by raw material manufacturing, and finally, nano-enabled product manufacturing; 4) the studies primarily reported the concentration/quantity of emitted ENMs, whereas the physical chemical characteristics of emitted ENMs were rarely measured or reported; and 5) the published literature primarily focused on emissions of silver and titanium dioxide ENMs and lacked similar information on other surging metallic and metal oxide ENMs such as nano-zero valent iron (nZVI), aluminum (Al), and aluminum oxide (Al2O3) ENMs. The evidence suggests that emitted nanoparticles into the air cover a wide range of concentrations below and above the allowable occupational exposure limits. The concentrations of nanoparticles in water systems are considered in the toxic to very toxic range for a variety of biological species. Given the critical gaps in knowledge, one cannot read across different sources of emissions for metallic and metal oxide ENMs hampering efforts with respect to understanding realistic scenarios for transformations in the natural environment and biological media. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Tolaymat, Thabet] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. [El Badawy, Amro; Genaidy, Ash; Abdelraheem, Wael; Sequeira, Reynold] WorldTek Inc, Cincinnati, OH USA. [Abdelraheem, Wael] Sohag Univ, Fac Sci, Dept Chem, Sohag 82524, Egypt. RP Tolaymat, T (reprint author), US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. EM thabet.tolaymat@epa.gov FU U.S EPA Office of Research and Development FX This research was funded by the U.S EPA Office of Research and Development. The manuscript has been subjected to the Agency's review process and approved for publication. The opinions expressed in this paper are those of the author(s) and do not reflect the official positions and policies of the USEPA. Any mention of products or trade names does not constitute recommendation for use by the USEPA. NR 99 TC 0 Z9 0 U1 12 U2 12 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0959-6526 EI 1879-1786 J9 J CLEAN PROD JI J. Clean Prod. PD FEB 1 PY 2017 VL 143 BP 401 EP 412 DI 10.1016/j.jclepro.2016.12.094 PG 12 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental; Environmental Sciences SC Science & Technology - Other Topics; Engineering; Environmental Sciences & Ecology GA EI8WN UT WOS:000392789000038 ER PT J AU Kolpin, DW Furlong, ET Glassmeyer, ST AF Kolpin, Dana W. Furlong, Edward T. Glassmeyer, Susan T. TI An introduction to joint research by the USEPA and USGS on contaminants of emerging concern in source and treated drinking waters of the United States SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Editorial Material C1 [Kolpin, Dana W.] US Geol Survey, Iowa Water Sci Ctr, 400 S Clinton St,Rm 269 Fed Bldg, Iowa City, IA 52240 USA. [Furlong, Edward T.] US Geol Survey, Denver Fed Ctr, Natl Water Qual Lab, Bldg 95, Denver, CO 80225 USA. [Glassmeyer, Susan T.] US EPA, Off Res & Dev, Natl Exposure Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. RP Kolpin, DW (reprint author), US Geol Survey, Iowa Water Sci Ctr, 400 S Clinton St,Rm 269 Fed Bldg, Iowa City, IA 52240 USA. EM dwkolpin@usgs.gov; efurlong@usgs.gov; glassmeyer.susan@epa.gov NR 0 TC 0 Z9 0 U1 3 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD FEB 1 PY 2017 VL 579 BP 1608 EP 1609 DI 10.1016/j.scitotenv.2016.03.052 PG 2 WC Environmental Sciences SC Environmental Sciences & Ecology GA EJ6HP UT WOS:000393320400060 PM 28040192 ER PT J AU Conley, JM Evans, N Mash, H Rosenblum, L Schenck, K Glassmeyer, S Furlong, ET Kolpin, DW Wilson, VS AF Conley, Justin M. Evans, Nicola Mash, Heath Rosenblum, Laura Schenck, Kathleen Glassmeyer, Susan Furlong, Ed T. Kolpin, Dana W. Wilson, Vickie S. TI Comparison of in vitro estrogenic activity and estrogen concentrations in source and treated waters from 25 US drinking water treatment plants SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Effect-based monitoring; In vitro bioassay; Drinking water; Estrogen; Water quality; T47D-KBluc ID ENDOCRINE-DISRUPTING COMPOUNDS; STEROID ESTROGENS; PIMEPHALES-PROMELAS; STABLY EXPRESSES; FATHEAD MINNOWS; WASTE-WATER; CELL-LINE; 17-BETA-ESTRADIOL; FISH; CONTAMINANTS AB In vitro bioassays have been successfully used to screen for estrogenic activity in wastewater and surface water, however, few have been applied to treated drinking water. Here, extracts of source and treated water samples were assayed for estrogenic activity using T47D-KBluc cells and analyzed by liquid chromatography-Fourier transform mass spectrometry (LC-FTMS) for natural and synthetic estrogens (including estrone, 17 beta-estradiol, estriol, and ethinyl estradiol). None of the estrogens were detected above the LC-FTMS quantification limits in treated samples and only 5 source waters had quantifiable concentrations of estrone, whereas 3 treated samples and 16 source samples displayed in vitro estrogenicity. Estrone accounted for the majority of estrogenic activity in respective samples, however the remaining samples that displayed estrogenic activity had no quantitative detections of known estrogenic compounds by chemical analyses. Source water estrogenicity (max, 0.47 ng 17 beta-estradiol equivalents (E2Eq)L-1) was below levels that have been linked to adverse effects in fish and other aquatic organisms. Treated water estrogenicity (max, 0.078 ng E2Eq L-1) was considerably below levels that are expected to be biologically relevant to human consumers. Overall, the advantage of using in vitro techniques in addition to analytical chemical determinations was displayed by the sensitivity of the T47D-KBluc bioassay, coupled with the ability to measure cumulative effects of mixtures, specifically when unknown chemicals may be present. Published by Elsevier B.V. C1 [Conley, Justin M.; Evans, Nicola; Wilson, Vickie S.] US EPA, Tox Assessment Div, Res Triangle Pk, NC 27711 USA. [Conley, Justin M.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Mash, Heath; Schenck, Kathleen] US EPA, Water Supply & Water Resources Div, Cincinnati, OH 45268 USA. [Rosenblum, Laura] CB&I Fed Serv, Cincinnati, OH USA. [Glassmeyer, Susan] US EPA, Microbial & Chem Exposure Assessment Res Div, Cincinnati, OH 45268 USA. [Furlong, Ed T.] US Geol Survey, Natl Water Qual Lab, Box 25046, Denver, CO 80225 USA. [Kolpin, Dana W.] US Geol Survey, Iowa Water Sci Ctr, Iowa City, IA USA. RP Wilson, VS (reprint author), US EPA, B105-04,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM wilson.vickie@epa.gov OI Conley, Justin M./0000-0002-6622-5769; Wilson, Vickie/0000-0003-1661-8481 FU USEPA [DW14922330]; USEPA's Office of Research and Development, Office of Water, Office of Chemical Safety and Pollution Prevention, and Region 8 FX The authors declare no competing financial interest. The information in this document has been funded partially or wholly by the USEPA. The research described in this article has been funded in part by the USEPA through Interagency Agreement DW14922330 to the USGS, and through programmatic support of the USGS' Toxic Substances Hydrology Program and the USEPA's Office of Research and Development, Office of Water, Office of Chemical Safety and Pollution Prevention, and Region 8. Information Collection Rule approval for the Phase II Questionnaire was granted under USEPA ICR No. 2346.01, OMB Control No. 2080-0078. This manuscript has been subjected to review by the National Health and Environmental Effects Research Laboratory and approved for publication. Approval does not signify that the contents reflect the views of the USEPA and mention of trade names or commercial products does not constitute endorsement or recommendation for use by USEPA. This document has been reviewed in accordance with USGS policy and approved for publication. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the U.S. Government. The authors would like to thank all participating DWTPs for their involvement in the project and for their assistance in collecting the samples. The authors would also like to thank Earl Gray (USEPA) and Dan Villeneuve (USEPA) for feedback on earlier drafts of the manuscript. JMC was supported in part by an appointment to the Internship/Research Participation Program at the Office of Research and Development, USEPA, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USEPA. NR 49 TC 3 Z9 3 U1 10 U2 10 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD FEB 1 PY 2017 VL 579 BP 1610 EP 1617 DI 10.1016/j.scitotenv.2016.02.093 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA EJ6HP UT WOS:000393320400061 PM 26936661 ER PT J AU Batt, AL Furlong, ET Mash, HE Glassmeyer, ST Kolpin, DW AF Batt, Angela L. Furlong, Edward T. Mash, Heath E. Glassmeyer, Susan T. Kolpin, Dana W. TI The importance of quality control in validating concentrations of contaminants of emerging concern in source and treated drinking water samples SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Pharmaceuticals; Contaminants of emerging concern; Drinking water; Source water; Mass spectrometry ID PERFORMANCE LIQUID-CHROMATOGRAPHY; TANDEM MASS-SPECTROMETRY; SOLID-PHASE EXTRACTION; WASTE-WATER; ENVIRONMENTAL-SAMPLES; DIRECT-INJECTION; SURFACE-WATER; PHARMACEUTICALS; MS/MS; SUBSTANCES AB A national-scale survey of 247 contaminants of emerging concern (CECs), including organic and inorganic chemical compounds, and microbial contaminants, was conducted in source and treated drinking water samples from 25 treatment plants across the United States. Multiple methods were used to determine these CECs, including six analytical methods to measure 174 pharmaceuticals, personal care products, and pesticides. A three-component quality assurance/quality control (QA/QC) program was designed for the subset of 174 CECs which allowed us to assess and compare performances of the methods used. The three components included: 1) a common field QA/QC protocol and sample design, 2) individual investigator-developed method-specific QA/QC protocols, and 3) a suite of 46 method comparison analytes that were determined in two or more analytical methods. Overall method performance for the 174 organic chemical CECs was assessed by comparing spiked recoveries in reagent, source, and treated water over a two-year period. In addition to the 247 CECs reported in the larger drinking water study, another 48 pharmaceutical compounds measured did not consistently meet predetermined quality standards. Methodologies that did not seem suitable for these analytes are overviewed. The need to exclude analytes based on method performance demonstrates the importance of additional QA/QC protocols. Published by Elsevier B.V. C1 [Batt, Angela L.; Glassmeyer, Susan T.] US EPA, Off Res & Dev, Natl Exposure Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. [Furlong, Edward T.] USGS, Natl Water Qual Lab, Denver Fed Ctr, Bldg 95, Denver, CO 80225 USA. [Mash, Heath E.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. [Kolpin, Dana W.] USGS, 400 S Clinton St,Rm 269 Fed Bldg, Iowa City, IA 52240 USA. RP Batt, AL (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM batt.angela@epa.gov; efurlong@usgs.gov; mash.heath@epa.gov; glassmeyer.susan@epa.gov; dwkolpin@usgs.gov FU U.S. Environmental Protection Agency [DW14922330]; USEPA's Office of Research and Development, Office of Water, Office of Chemical Safety and Pollution Prevention, and Region 8 FX The authors declare no competing financial interest. The information in this document has been funded partially or wholly by the U.S. Environmental Protection Agency. The research described in this article has been funded in part by the U.S. Environmental Protection Agency through Interagency Agreement DW14922330 to the U.S. Geological Survey, and through programmatic support of the USGSToxic Substances Hydrology Program and the USEPA's Office of Research and Development, Office of Water, Office of Chemical Safety and Pollution Prevention, and Region 8. Information Collection Rule approval for the Phase II Questionnaire was granted under EPA ICR No. 2346.01, OMB Control No. 2080-0078. This manuscript has been reviewed in accordance with USEPA policy and approved for publication. Approval does not signify that the contents reflect the views or policies of the USEPA and mention of trade names or commercial products does not constitute endorsement or recommendation for use by USEPA. This document has also been reviewed in accordance with USGS policy and approved for publication. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the U.S. Government. The authors would like to thank all participating drinking water treatment plants for their involvement in the project and for their assistance in collecting the samples. The authors would like to acknowledge Laura J. Coffey, Michael Eastham, Hayden Miracle, Mary C. Noriega, Laura Rosenblum, and Sarah Watson for their assistance in sample preparation and/or data analysis. NR 42 TC 1 Z9 1 U1 7 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD FEB 1 PY 2017 VL 579 BP 1618 EP 1628 DI 10.1016/j.scitotenv.2016.02.127 PG 11 WC Environmental Sciences SC Environmental Sciences & Ecology GA EJ6HP UT WOS:000393320400062 PM 28040193 ER PT J AU Furlong, ET Batt, AL Glassmeyer, ST Noriega, MC Kolpin, DW Mash, H Schenck, KM AF Furlong, Edward T. Batt, Angela L. Glassmeyer, Susan T. Noriega, Mary C. Kolpin, Dana W. Mash, Heath Schenck, Kathleen M. TI Nationwide reconnaissance of contaminants of emerging concern in source and treated drinking waters of the United States: Pharmaceuticals SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Pharmaceuticals; Contaminants of emerging concern; Drinking water; Source water; Treated water ID SOLID-PHASE EXTRACTION; WASTE-WATER; SURFACE-WATER; ORGANIC-COMPOUNDS; PERSISTENCE; LITHIUM; ENVIRONMENT; INDICATORS; PLANT; US AB Mobile and persistent chemicals that are present in urban wastewater, such as pharmaceuticals, may survive on-site or municipal wastewater treatment and post-discharge environmental processes. These pharmaceuticals have the potential to reach surface and groundwaters, essential drinking-water sources. A joint, two-phase U.S. Geological Survey-U.S. Environmental Protection Agency study examined source and treated waters from 25 drinking-water treatment plants from across the United States. Treatment plants that had probable wastewater inputs to their source waters were selected to assess the prevalence of pharmaceuticals in such source waters, and to identify which pharmaceuticals persist through drinking-water treatment. All samples were analyzed for 24 pharmaceuticals in Phase I and for 118 in Phase II. In Phase I, 11 pharmaceuticals were detected in all source-water samples, with a maximum of nine pharmaceuticals detected in any one sample. The median number of pharmaceuticals for all 25 samples was five. Quantifiable pharmaceutical detections were fewer, with a maximum of five pharmaceuticals in any one sample and a median for all samples of two. In Phase II, 47 different pharmaceuticals were detected in all source-water samples, with a maximum of 41 pharmaceuticals detected in any one sample. The median number of pharmaceuticals for all 25 samples was eight. For 37 quantifiable pharmaceuticals in Phase II, median concentrations in source water were below 113 ng/L. For both Phase I and Phase II campaigns, substantially fewer pharmaceuticals were detected in treated water samples than in corresponding source-water samples. Seven different pharmaceuticals were detected in all Phase I treated water samples, with a maximum of four detections in any one sample and a median of two pharmaceuticals for all samples. In Phase II a total of 26 different pharmaceuticals were detected in all treated water samples, with a maximum of 20 pharmaceuticals detected in any one sample and a median of 2 pharmaceuticals detected for all 25 samples. Source-water type influences the presence of pharmaceuticals in source and treated water. Treatment processes appear effective in reducing concentrations of most pharmaceuticals. Pharmaceuticals more consistently persisting through treatment include carbamazepine, bupropion, cotinine, metoprolol, and lithium. Pharmaceutical concentrations and compositions from this study provide an important base data set for further sublethal, long-term exposure assessments, and for understanding potential effects of these and other contaminants of emerging concern upon human and ecosystem health. (C) 2016 Published by Elsevier B.V. C1 [Furlong, Edward T.; Noriega, Mary C.] US Geol Survey, Box 25046, Denver, CO 80225 USA. [Batt, Angela L.; Glassmeyer, Susan T.; Mash, Heath; Schenck, Kathleen M.] US EPA, Cincinnati, OH 45268 USA. [Kolpin, Dana W.] US Geol Survey, Iowa City, IA USA. RP Furlong, ET (reprint author), US Geol Survey, Natl Water Qual Lab, Denver Fed Ctr, POB 25585, Denver, CO 80225 USA. FU U.S. Environmental Protection Agency [DW14922330]; USEPA's Office of Research and Development, Office of Water, Office of Chemical Safety and Pollution Prevention, and Region 8 FX The authors declare no competing financial interest. The information in this document has been funded partially or wholly by the U.S. Environmental Protection Agency. The research described in this article has been funded in part by the U.S. Environmental Protection Agency through Interagency Agreement DW14922330 to the U.S. Geological Survey, and through programmatic support of the USGS' Toxic Substances Hydrology Program and the USEPA's Office of Research and Development, Office of Water, Office of Chemical Safety and Pollution Prevention, and Region 8. Information Collection Rule approval for the Phase II Questionnaire was granted under USEPA ICR No. 2346.01, OMB Control No. 2080-0078. This manuscript has been subjected to review by the National Exposure Research Laboratory and approved for publication. Approval does not signify that the contents reflect the views of the USEPA and mention of trade names or commercial products does not constitute endorsement or recommendation for use by USEPA. This document has been reviewed in accordance with USGS policy and approved for publication. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the U.S. Government. The authors would like to thank all participating DWTPs for their involvement in the project and for their assistance in collecting the samples. The authors would also like to thank the following personnel for sample and data analysis assistance: Steve Werner, Laura Coffey, and Laura Rosenblum. NR 37 TC 1 Z9 1 U1 19 U2 19 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD FEB 1 PY 2017 VL 579 BP 1629 EP 1642 DI 10.1016/j.scitotenv.2016.03.128 PG 14 WC Environmental Sciences SC Environmental Sciences & Ecology GA EJ6HP UT WOS:000393320400063 PM 28040194 ER PT J AU Benson, R Conerly, OD Sander, W Batt, AL Boone, JS Furlong, ET Glassmeyer, ST Kolping, DW Mash, HE Schenck, KM Simmons, JE AF Benson, Robert Conerly, Octavia D. Sander, William Batt, Angela L. Boone, J. Scott Furlong, Edward T. Glassmeyer, Susan T. Kolpin, Dana W. Mash, Heath E. Schenck, Kathleen M. Simmons, Jane Ellen TI Human health screening and public health significance of contaminants of emerging concern detected in public water supplies SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Drinking water; Contaminants of emerging concern; Human health; Margin of Exposure ID DRINKING-WATER; MANGANESE; MIXTURES; LITHIUM AB The source water and treated drinking water from twenty five drinking water treatment plants (DWTPs) across the United States were sampled in 2010-2012. Samples were analyzed for 247 contaminants using 15 chemical and microbiological methods. Most of these contaminants are not regulated currently either in drinking water or in discharges to ambient water by the U.S. Environmental Protection Agency (USEPA) or other U.S. regulatory agencies. This analysis shows that there is little public health concern for most of the contaminants detected in treated water from the 25 DWTPs participating in this study. For vanadium, the calculated Margin of Exposure (MOE) was less than the screening MOE in two DWTPs. For silicon, the calculated MOE was less than the screening MOE in one DWTP. Additional study, for example a national survey may be needed to determine the number of people ingesting vanadium and silicon above a level of concern. In addition, the concentrations of lithium found in treated water from several DWTPs are within the range previous research has suggested to have a human health effect. Additional investigation of this issue is necessary. Finally, new toxicological data suggest that exposure to manganese at levels in public water supplies may present a public health concern which will require a robust assessment of this information. Published by Elsevier B.V. C1 [Benson, Robert] US EPA, Reg 8,1595 Wynkoop, Denver, CO 80202 USA. [Conerly, Octavia D.] US EPA, Off Water Off Sci & Technol, William Jefferson Clinton Bldg,1200 Penn Ave NW, Washington, DC 20460 USA. [Sander, William] AAAS, William Jefferson Clinton Bldg,1200 Penn Ave NW, Washington, DC 20460 USA. [Boone, J. Scott; Glassmeyer, Susan T.] US EPA, Off Res & Dev, Natl Exposure Res Lab, 26 Martin Luther King Dr, Cincinnati, OH 45268 USA. [Boone, J. Scott] US EPA, Off Chem Safety & Pollut Prevent, Stennis Space Port, MS USA. [Furlong, Edward T.] USGS, Natl Water Qual Lab, Denver Fed Ctr, POB 25585,Bldg 95, Denver, CO 80225 USA. [Kolpin, Dana W.] USGS, Iowa Water Sci Ctr, POB 1230, Iowa City, IA 52244 USA. [Mash, Heath E.; Schenck, Kathleen M.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. [Simmons, Jane Ellen] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Div, 109 TW Alexander Dr, Res Triangle Pk, NC 27709 USA. [Sander, William] Booz Allen Hamilton, 8209 Terminal Rd, Lorton, VA 22079 USA. [Boone, J. Scott] Mississippi State Chem Lab, 310 President Circle,POB CR, Mississippi State, MS 39762 USA. RP Benson, R (reprint author), US EPA, Reg 8,1595 Wynkoop, Denver, CO 80202 USA. EM Benson.bob@epa.gov; Conerly.octavia@epa.gov; Sander_William@bah.com; Batt.angela@epa.gov; sboone@mscl.msstate.edu; Efurlong@usgs.gov; Glassmeyer.susan@epa.gov; dwkolpin@usgs.gov; mash.heath@epa.gov; schenck.kathleen@epa.gov; Simmons.jane@epa.gov FU U.S. Environmental Protection Agency [DW14922330]; USEPA's Office of Research and Development, Office of Water, Office of Chemical Safety and Pollution Prevention, and Region 8 FX The authors declare no competing financial interest. The information in this document has been funded partially or wholly by the U.S. Environmental Protection Agency. The research described in this article has been funded in part by the U.S. Environmental Protection Agency through Interagency Agreement DW14922330 to the U.S. Geological Survey, and through programmatic support of the USGS' Toxic Substances Hydrology Program and the USEPA's Office of Research and Development, Office of Water, Office of Chemical Safety and Pollution Prevention, and Region 8. Information Collection Rule approval for the Phase II Questionnaire was granted under USEPA ICR No. 2346.01, OMB Control No. 2080-0078. This manuscript has been subjected to review by the USEPA National Health and Environmental Effects Research Laboratory and by the USEPA Office of Water and approved for publication. Approval does not signify that the contents reflect the views of the USEPA and mention of trade names or commercial products does not constitute endorsement or recommendation for use by USEPA. This document has been reviewed in accordance with USGS policy and approved for publication. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the U.S. Government. The authors would like to thank all participating DWTPs for their involvement in the project and for their assistance in collecting the samples. NR 25 TC 2 Z9 2 U1 6 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD FEB 1 PY 2017 VL 579 BP 1643 EP 1648 DI 10.1016/j.scitotenv.2016.03.146 PG 6 WC Environmental Sciences SC Environmental Sciences & Ecology GA EJ6HP UT WOS:000393320400064 PM 28040195 ER PT J AU Kostich, MS Flick, RW Batt, AL Mash, HE Boone, JS Furlong, ET Kolpin, DW Glassmeyer, ST AF Kostich, Mitchell S. Flick, Robert W. Batt, Angela L. Mash, Heath E. Boone, J. Scott Furlong, Edward T. Kolpin, Dana W. Glassmeyer, Susan T. TI Aquatic concentrations of chemical analytes compared to ecotoxicity estimates SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Contaminant; Hazard; Aquatic ID ACUTE TOXICITY; DAPHNIA-MAGNA; METALS; MODEL; PHARMACEUTICALS; PHOSPHORUS; SURVIVAL; NITRATE; FISH AB We describe screening level estimates of potential aquatic toxicity posed by 227 chemical analytes that were measured in 25 ambient water samples collected as part of a joint USGS/USEPA drinking water plant study. Measured concentrations were compared to biological effect concentration (EC) estimates, including USEPA aquatic life criteria, effective plasma concentrations of pharmaceuticals, published toxicity data summarized in the USEPA ECOTOX database, and chemical structure-based predictions. Potential dietary exposures were estimated using a generic 3-tiered food web accumulation scenario. For many analytes, few or no measured effect data were found, and for some analytes, reporting limits exceeded EC estimates, limiting the scope of conclusions. Results suggest occasional occurrence above ECs for copper, aluminum, strontium, lead, uranium, and nitrate. Sparse effect data for manganese, antimony, and vanadium suggest that these analytes may occur above ECs, but additional effect data would be desirable to corroborate EC estimates. These conclusions were not affected by bioaccumulation estimates. No organic analyte concentrations were found to exceed EC estimates, but ten analytes had concentrations in excess of 1/10th of their respective EC: triclocarban, norverapamil, progesterone, atrazine, metolachlor, triclosan, para-nonylphenol, ibuprofen, venlafaxine, and amitriptyline, suggesting more detailed characterization of these analytes. Published by Elsevier B.V. C1 [Kostich, Mitchell S.; Flick, Robert W.] US EPA, ORD NERL EMMD, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. [Batt, Angela L.; Glassmeyer, Susan T.] US EPA, ORD NERL SED, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. [Mash, Heath E.] US EPA, ORD NRMRL WSWRD, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. [Boone, J. Scott] US EPA, OPPTS OPP BEAD, John C Stennis Space Ctr, Mail Code 7503 ECB, Stennis Space Ctr, MS 39529 USA. [Furlong, Edward T.] US Geol Survey, POB 25585, Denver, CO 80225 USA. [Kolpin, Dana W.] US Geol Survey, 400 South Clinton St, Iowa City, IA 52240 USA. [Boone, J. Scott] Mississippi State Chem Lab, POB CR, Mississippi State, MS 39762 USA. RP Kostich, MS (reprint author), US EPA, ORD NERL EMMD, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM kostich.mitchell@epa.gov FU U.S. Environmental Protection Agency [DW14922330]; USEPA's Office of Research and Development, Office of Water, Office of Chemical Safety and Pollution Prevention, and Region 8 FX The research described in this article has been funded in part by the U.S. Environmental Protection Agency through Interagency Agreement DW14922330 to the U.S. Geological Survey, and through programmatic support of the USGS' Toxic Substances Hydrology Program and the USEPA's Office of Research and Development, Office of Water, Office of Chemical Safety and Pollution Prevention, and Region 8. Information Collection Rule approval for the Phase II Questionnaire was granted under EPA ICR No. 2346.01, OMB Control No. 2080-0078. This document has been reviewed in accordance with USEPA and USGS policy and approved for publication. Approval does not signify that the contents reflect the views of the USEPA and mention of trade names or commercial products does not constitute endorsement or recommendation for use by USEPA. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the U.S. Government. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. The authors would like to thank all participating drinking water treatment plants for their involvement in the project and for their assistance in collecting the samples. NR 44 TC 1 Z9 1 U1 15 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD FEB 1 PY 2017 VL 579 BP 1649 EP 1657 DI 10.1016/j.scitotenv.2016.06.234 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA EJ6HP UT WOS:000393320400065 PM 28040196 ER PT J AU Kotchenruther, RA AF Kotchenruther, Robert A. TI The effects of marine vessel fuel sulfur regulations on ambient PM2.5 at coastal and near coastal monitoring sites in the US SO ATMOSPHERIC ENVIRONMENT LA English DT Article DE PM2.5; Marine vessel emissions; Positive matrix factorization; Source apportionment; Residual fuel oil; Emissions control area ID SOURCE APPORTIONMENT; PARTICULATE MATTER; ESTIMATING UNCERTAINTY; DIESEL-ENGINE; EMISSIONS; PARTICLES; IMPACTS; AREA AB In August of 2012 the U.S. began implementing fuel sulfur limits on certain large commercial marine vessels within 200 nautical miles (nm) of its coasts as part of a North American Emissions Control Area (NA-ECA). The NA-ECA limited fuel sulfur use in these vessels to below 1% in 2012 and to below 0.1% starting in 2015. This work uses ambient PM2.5 monitoring data from the U.S. IMPROVE network and Positive Matrix Factorization (PMF) receptor modeling to assess the effectiveness of the NA-ECA at reducing ambient PM2.5 from highsulfur residual fuel oil (RFO) use. RFO combustion emissions of PM2.5 are known to have a fairly unique vanadium (V) and nickel (Ni) trace metal signature. To determine if IMPROVE sites were affected by residual fuel oil combustion, V and Ni data from 65 IMPROVE sites in coastal States of the U.S. were analyzed from 2010 to 2011, the two years prior to NA-ECA implementation. 22 of these IMPROVE sites had a V and Ni correlation coefficient (r(2)) greater than 0.65 and were selected for further analysis by PMF. The slopes of the correlations between V and Ni at these 22 sites ranged from 2.2 to 4.1, consistent with reported V:Ni emission ratios from RFO combustion. Each of the 22 IMPROVE sites was modeled independently with PMF, using the available PM2.5 chemical speciation data from 2010 to 2015. PMF model solutions for the 22 sites contained from 5 to 9 factors, depending on the site. At every site a PMF factor was identified that was associated with RFO combustion, however, 9 sites had PMF factors where RFO combustion was mixed with other aerosol sources. For the remaining 13 sites, PM2,5 from RFO combustion was analyzed for three time periods; 2010-2011 representing the time period prior to the NA-ECA implementation (pre-NA-ECA), 2013-2014 representing the time period where fuel sulfur was limited to 1.0% (NA-ECA 1.0% S), and 2015 representing the time period where fuel sulfur was limited to 0.1% (NA-ECA 0.1% S). All 13 sites indicated statistically significant reductions in the contribution of RFO combustion to PM2.5 between the pre-NA-ECA period and the two periods of fuel sulfur control. The average decrease in annual average PM2.5 from RFO combustion from the pre-NA-ECA to NA-ECA 1% S period was 50.2% (range, 29.0%-65.4%) and from the pre-NA-ECA to NA-ECA 0.1% S period was 74.1% (range, 33.0%-90.4%). Published by Elsevier Ltd. C1 [Kotchenruther, Robert A.] US Environm Protect Agcy Reg 10, Off Environm Review & Assessment, 1200 Sixth Ave,Mailstop OEA-140, Seattle, WA 98101 USA. EM Kotchenruther.Robert@epa.gov NR 30 TC 0 Z9 0 U1 8 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 EI 1873-2844 J9 ATMOS ENVIRON JI Atmos. Environ. PD FEB PY 2017 VL 151 BP 52 EP 61 DI 10.1016/j.atmosenv.2016.12.012 PG 10 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA EI7KZ UT WOS:000392678000007 ER PT J AU Tolaymat, T Genaidy, A Abdelraheern, W Dionysiou, D Andersen, C AF Tolaymat, Thabet Genaidy, Ash Abdelraheern, Wael Dionysiou, Dionysios Andersen, Christian TI The effects of metallic engineered nanoparticles upon plant systems: An analytic examination of scientific evidence SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Metallic engineered nanoparticles; Metal ions; Plant system; Society-Environment-Economy; Stimulatory effects; Inhibitory effects ID WHEAT TRITICUM-AESTIVUM; VALENT IRON NZVI; SILVER NANOPARTICLES; ARABIDOPSIS-THALIANA; COPPER NANOPARTICLES; GENE-EXPRESSION; OXIDE NANOPARTICLES; GOLD NANOPARTICLES; PHASEOLUS-RADIATUS; SEED-GERMINATION AB Recent evidence for the effects of metallic engineered nanoparticles (ENPs) on plants and plant systems was examined together with its implications for other constituents of the Society-Environment-Economy (SEE) system. In this study, we were particularly interested to determine whether or not metallic ENPs have both stimulatory and inhibitory effects upon plant performance. An emphasis was made to analyze the scientific evidence on investigations examining both types of effects in the same studies. Analysis of evidence demonstrated that metallic ENPs have both stimulatory and inhibitory effects mostly in well-controlled environments and soilless media. Nano zero-valent iron (nZVI) and Cu ENPs have potential for use as micronutrients for plant systems, keeping in mind the proper formulation at the right dose for each type of ENP. The concentration levels for the stimulatory effects of Cu ENPs are lower than for those for nZVI. Newer findings showed that extremely smaller concentrations of Au ENPs (smaller than those for nZVI and Cu ENPs) induce positive effects for plant growth, which is attributed to effects on secondary metabolites. Ag ENPs have demonstrated their usage as antimicrobial/pesticidal agents for plant protection; however, precautions should be taken to avoid higher concentrations not only for plant systems, but also, other constituents in the SEE. Further research is warranted to investigate the stimulatory and inhibitory effects of metallic ENPs in soil media in order to broaden the horizon of sustainable agriculture production in terms of higher and safer yields so as to meet the food requirements of human population. (C) 2016 Published by Elsevier B.V. C1 [Tolaymat, Thabet] US EPA, Off Res & Dev, Cincinnati, OH 45221 USA. [Genaidy, Ash; Abdelraheern, Wael] WorldTek Inc, Cincinnati, OH 45249 USA. [Abdelraheern, Wael] Sohag Univ, Dept Chem, Fac Sci, Sohag 82524, Egypt. [Dionysiou, Dionysios] Univ Cincinnati, Environm Engn Program, Cincinnati, OH 45221 USA. [Andersen, Christian] US EPA, Natl Hlth & Environm Effects Res Lab, Corvalis, OR 97333 USA. RP Tolaymat, T (reprint author), US EPA, Off Res & Dev, Cincinnati, OH 45221 USA. EM tolaymatthabet@epa.gov NR 91 TC 0 Z9 0 U1 18 U2 18 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD FEB 1 PY 2017 VL 579 BP 93 EP 106 DI 10.1016/j.scitotenv.2016.10.229 PG 14 WC Environmental Sciences SC Environmental Sciences & Ecology GA EH6QA UT WOS:000391897800010 PM 27871749 ER PT J AU Fulk, F Succop, P Hilbert, TJ Beidler, C Brown, D Reponen, T Haynes, EN AF Fulk, Florence Succop, Paul Hilbert, Timothy J. Beidler, Caroline Brown, David Reponen, Tiina Haynes, Erin N. TI Pathways of inhalation exposure to manganese in children living near a ferromanganese refinery: A structural equation modeling approach SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Structural equation model (SEM); Dispersion modeling; Dust; Hair; Blood ID CHILDHOOD EXPOSURE; YOUNG-CHILDREN; LEAD-EXPOSURE; DUST; POLLUTION; SYMPTOMS; CADMIUM; WORKERS; HOUSE; HAIR AB Manganese (Mn) is both essential element and neurotoxicant. Exposure to Mn can occur from various sources and routes. Structural equation modeling was used to examine routes of exposure to Mn among children residing near a ferromanganese refinery in Marietta, Ohio. An inhalation pathway model to ambient air Mn was hypothesized. Data for model evaluation were obtained from participants in the Communities Actively Researching Exposure Study (CARES). These data were collected in 2009 and included levels of Mn in residential soil and dust, levels of Mn in children's hair, information on the amount of time the child spent outside, heat and air conditioning in the home and level of parent education. Hair Mn concentration was the primary endogenous variable used to assess the theoretical inhalation exposure pathways. The model indicated that household dust Mn was a significant contributor to child hair Mn (0.37). Annual ambient air Mn concentration (0.26), time children spent outside (0.24) and soil Mn (024) significantly contributed to the amount of Mn in household dust. These results provide a potential framework for understanding the inhalation exposure pathway for children exposed to ambient air Mn who live in proximity to an industrial emission source. (C) 2016 Elsevier B.V. All rights reserved. C1 [Fulk, Florence] US EPA, Natl Exposure Res Lab, Washington, DC 20460 USA. [Succop, Paul; Hilbert, Timothy J.; Reponen, Tiina; Haynes, Erin N.] Univ Cincinnati, Dept Environm Hlth, Coll Med, Cincinnati, OH 45221 USA. [Beidler, Caroline] Neighbors Clean Air, New York, NY USA. [Brown, David] Marietta Coll, Dept Biol & Environm Sci, Marietta, GA USA. RP Haynes, EN (reprint author), Univ Cincinnati, 160 Panzeca Way, Cincinnati, OH 45267 USA. EM Erin.Haynes@uc.edu FU National Institute of Environmental Health Sciences [1R01 ES016531-01, P30-ES006096]; Institutional Clinical and Translational Science Award [NIH/NCRR 5UL1RR026314] FX This work was supported by funding from National Institute of Environmental Health Sciences (1R01 ES016531-01; P30-ES006096) and an Institutional Clinical and Translational Science Award, NIH/NCRR 5UL1RR026314. This work was completed in partial fulfillment of the Doctor of Philosophy degree in Epidemiology in the Department of Environmental Health, Division of Epidemiology and Biostatistics, University of Cincinnati College of Medicine. The views expressed in this paper are those of the authors and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency or NIEHS. NR 47 TC 0 Z9 0 U1 4 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD FEB 1 PY 2017 VL 579 BP 768 EP 775 DI 10.1016/j.scitotenv.2016.11.030 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA EH6QA UT WOS:000391897800079 PM 27865527 ER PT J AU Wang, DJ Shen, CY Jin, Y Su, CM Chu, LY Zhou, DM AF Wang, Dengjun Shen, Chongyang Jin, Yan Su, Chunming Chu, Lingyang Zhou, Dongmei TI Role of solution chemistry in the retention and release of graphene oxide nanomaterials in uncoated and iron oxide-coated sand SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Graphene oxide nanomaterials; Uncoated and iron oxide-coated sand; Transient solution chemistry; Retention; Release; Surface element integration ID SATURATED POROUS-MEDIA; UNFAVORABLE CHEMICAL CONDITIONS; HYDROXYAPATITE NANOPARTICLES; COLLOID RETENTION; HUMIC-ACID; FACILITATED TRANSPORT; DLVO INTERACTION; IONIC-STRENGTH; DEPOSITION; AGGREGATION AB Understanding the fate and transport induding remobilization of graphene oxide nanomaterials (GONMs) in the subsurface would enable us to expedite their benign use and evaluate their environmental impacts and health risks. In this study, the retention and release of GONMs were investigated in water-saturated columns packed with uncoated sand (Un-S) or iron oxide-coated sand (Fe-S) at environmentally relevant solution chemistries (1-100 mM KCl and 0.1-10 mM CaCl2 at pH 7 and 11). Our results showed that increasing ionic strength (IS) inhibited GONMs' transport and the impact of K+ was less than Ca2+. The positively charged iron oxide coating on sand surfaces immobilized the negatively charged GONMs (pH 7) in the primary minimum, yielding hyperexponential retention profiles particularly in Ca2+. A stepwise decrease in pore-water IS caused detachment of previously retained GONMs. The mass of GONMs released during each detachment step correlated positively with the difference in secondary minimum depth (Delta Phi(min2)) at each IS, indicating that the released GONMs were retained in the secondary minimum. While most retained GONMs were re-entrained upon lowering pore water IS in Un-S, decreasing IS only released limited GONMs in Fe-S, which were captured in the primary minimum. Introducing 1 mM NaOH (pH 11) released most retained GONMs in Fe-S; and average hydrodynamic diameters of the detached GONMs upon injecting NaOH were significantly smaller than those of GONMs in the influent and retentate, suggesting that NaOH induced GONMs disaggregation. Our findings advance current knowledge to better predict NMs' fate and transport under various solution chemistries such as during rainfall events or in the mixing zones between sea water and fresh water where transient IS changes drastically. (C) 2016 Elsevier B.V. All rights reserved. C1 [Wang, Dengjun; Chu, Lingyang; Zhou, Dongmei] Chinese Acad Sci, Inst Soil Sci, Key Lab Soil Environm & Pollut Remediat, Nanjing 210008, Jiangsu, Peoples R China. [Wang, Dengjun] Univ Chinese Acad Sci, Beijing 100049, Peoples R China. [Shen, Chongyang] China Agr Univ, Dept Soil & Water Sci, Beijing 100193, Peoples R China. [Jin, Yan] Univ Delaware, Dept Plant & Soil Sci, Newark, DE 19716 USA. [Su, Chunming] US EPA, Ground Water & Ecosyst Restorat Div, Natl Risk Management Res Lab, Off Res & Dev, Ada, OK 74820 USA. RP Zhou, DM (reprint author), Chinese Acad Sci, Inst Soil Sci, Key Lab Soil Environm & Pollut Remediat, Nanjing 210008, Jiangsu, Peoples R China. EM dmzhou@issas.ac.cn OI Wang, Dengjun/0000-0002-2047-5260 FU National Natural Science Foundation of China [41430752, 41125007]; National Basic Research and Development Program of China [2013CB934303] FX This research was supported by National Natural Science Foundation of China (41430752 and 41125007) and National Basic Research and Development Program of China (No 2013CB934303). We appreciate Dr. Dermont Bouchard and Dr. Souhail Al-Abed for their constructive comments and suggestions that improved the quality of this paper. This work does not necessarily reflect the views of the U.S. EPA, and no official endorsement should be inferred. NR 45 TC 0 Z9 0 U1 15 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD FEB 1 PY 2017 VL 579 BP 776 EP 785 DI 10.1016/j.scitotenv.2016.11.029 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA EH6QA UT WOS:000391897800080 PM 27866744 ER PT J AU Li, SB Villeneuve, DL Berninger, JP Blackwell, BR Cavallin, JE Hughes, MN Jensen, KM Jorgenson, Z Kahl, MD Schroeder, AL Stevens, KE Thomas, LM Weberg, MA Ankley, GT AF Li, Shibin Villeneuve, Daniel L. Berninger, Jason P. Blackwell, Brett R. Cavallin, Jenna E. Hughes, Megan N. Jensen, Kathleen M. Jorgenson, Zachary Kahl, Michael D. Schroeder, Anthony L. Stevens, Kyle E. Thomas, Linnea M. Weberg, Matthew A. Ankley, Gerald T. TI An integrated approach,for identifying priority contaminant in the Great Lakes Basin - Investigations in the Lower Green Bay/Fox River and Milwaukee Estuary areas of concern SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Mixture; Screening; Chemical-biomolecule interactions; ToxCast (TM); Contaminants of emerging concern; Risk assessment ID MINNOW PIMEPHALES-PROMELAS; FATHEAD MINNOW; BIOANALYTICAL TOOLS; ORGANIC MICROPOLLUTANTS; STABLY EXPRESSES; TOXCAST PROGRAM; RECYCLED WATER; DRINKING-WATER; WASTE-WATER; CELL-LINE AB Environmental assessment of complex mixtures typically requires integration of chemical and biological measurements. This study demonstrates the use of a combination of instrumental chemical analyses, effects-based monitoring, and bio-effects prediction approaches to help identify potential hazards and priority contaminants in two Great Lakes Areas of Concern (AOCs), the Lower Green Bay/Fox River located near Green Bay, WI, USA and the Milwaukee Estuary, located near Milwaukee, WI, USA. Fathead minnows were caged at four sites within each AOC (eight sites total). Following 4 d of in situ exposure, tissues and biofluids were sampled and used for targeted biological effects analyses. Additionally, 4 d composite water samples were collected concurrently at each caged fish site and analyzed for 132 analytes as well as evaluated for total estrogenic and androgenic activity using cell-based bioassays. Of the analytes examined, 75 were detected in composite samples from at least one site. Based on multiple analyses, one site in the East River and another site near a paper mill discharge in the Lower Green Bay/Fox River AOC, were prioritized due to their estrogenic and androgenic activity, respectively. The water samples from other sites generally did not exhibit significant estrogenic or androgenic activity, nor was there evidence for endocrine disruption in the fish exposed at these sites as indicated by the lack of alterations in ex vivo steroid production, circulating steroid concentrations, or vitellogenin mRNA expression in males. Induction of hepatic cyp1a mRNA expression was detected at several sites, suggesting the presence of chemicals that activate the aryl hydrocarbon receptor. To expand the scope beyond targeted investigation of endpoints selected a priori, several bio-effects prediction approaches were employed to identify other potentially disturbed biological pathways and related chemical constituents that may warrant future monitoring at these sites. For example, several chemicals such as diethylphthalate and naphthalene, and genes and related pathways, such as cholinergic receptor muscarinic 3 (CHRM3), estrogen receptor alpha1 (esr1), chemokine ligand 10 protein (OCCL10), tumor protein p53 (p53), and monoamine oxidase B (Maob), were identified as candidates for future assessments at these AOCs. Overall, this study demonstrates that a better prioritization of contaminants and associated hazards can be achieved through integrated evaluation of multiple lines of evidence. Such prioritization can guide more comprehensive follow-up risk assessment efforts. (C) 2016 Elsevier B.V. All rights reserved. C1 [Li, Shibin; Villeneuve, Daniel L.; Berninger, Jason P.; Blackwell, Brett R.; Cavallin, Jenna E.; Hughes, Megan N.; Jensen, Kathleen M.; Kahl, Michael D.; Stevens, Kyle E.; Thomas, Linnea M.; Weberg, Matthew A.; Ankley, Gerald T.] US EPA, Natl Hlth & Environm Effects Res Lab, Mid Continent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA. [Li, Shibin; Berninger, Jason P.] US EPA, Natl Res Council, 6201 Congdon Blvd, Duluth, MN 55804 USA. [Jorgenson, Zachary] US Fish & Wildlife Serv, Twin Cities Ecol Field Serv Field Off, 4101 Amer Blvd East, Bloomington, MN 55425 USA. [Schroeder, Anthony L.] Univ Minnesota Crookston, Math Sci & Technol Dept, 2900 Univ Ave, Crookston, MN 56716 USA. RP Li, SB (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Mid Continent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA. EM lishibin1116@gmail.com FU National Research Council Research Associateship Awards at the U.S. Environmental Protection Agency, Mid-Continent Ecology Division FX The present study was performed while two of the authors, Shibin Li and Jason P. Benninger, held National Research Council Research Associateship Awards at the U.S. Environmental Protection Agency, Mid-Continent Ecology Division. The authors also thank the following team members who have been critical in the implementation and success of the program that this study is a part of: Kathy lee (USGS), JoAnn Banda (USFWS), Steve Choy (USFWS), Dan Gefell (USFWS), and Jeremy Moore (USFWS). This document has been subjected to review by the National Health and Environmental Effects Research Laboratory and approved for publication. Approval does not signify that the contents reflect the views of the Agency nor does mention of trade names or commercial products constitute endorsement or recommendation for use. The findings and conclusions in this article are those of the authors and do not necessarily represent the views or policies of the corresponding agencies. NR 60 TC 0 Z9 0 U1 9 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD FEB 1 PY 2017 VL 579 BP 825 EP 837 DI 10.1016/j.scitotenv.2016.11.021 PG 13 WC Environmental Sciences SC Environmental Sciences & Ecology GA EH6QA UT WOS:000391897800085 PM 27866739 ER PT J AU Szabo, JG Meiners, G Heckman, L Rice, EW Hall, J AF Szabo, Jeffrey G. Meiners, Greg Heckman, Lee Rice, Eugene W. Hall, John TI Decontamination of Bacillus spores adhered to iron and cement-mortar drinking water infrastructure in a model system using disinfectants SO JOURNAL OF ENVIRONMENTAL MANAGEMENT LA English DT Article DE Drinking water; Decontamination; Disinfection; Bacillus; Spores ID SUBTILIS SPORES; ACIDIFIED NITRITE; CHLORINE DIOXIDE; INACTIVATION; OZONE; MONOCHLORAMINE; PENETRATION; PERSISTENCE; MECHANISMS; RESISTANCE AB Decontamination of Bacillus spores adhered to common drinking water infrastructure surfaces was evaluated using a variety of disinfectants. Corroded iron and cement-mortar lined iron represented the infrastructure surfaces, and were conditioned in a 23 m long, 15 cm diameter (75 ft long, 6 in diameter) pilot-scale drinking water distribution pipe system. Decontamination was evaluated using increased water velocity (flushing) alone at 0.5 m s(-1) (1.7 ft s(-1)), as well as free chlorine (5 and 25 mg L-1), monochloramine (25 mg L-1), chlorine dioxide (5 and 25 mg L-1), ozone (2.0 mg L-1), peracetic acid 25 mg L-1) and acidified nitrite (0.1 mol L-1 at pH 2 and 3), all followed by flushing at 0.3 m s(-1) (1 ft s(-1)). Flushing alone reduced the adhered spores by 0.5 and 2.0 log(10) from iron and cement-mortar, respectively. Log(10) reduction on corroded iron pipe wall coupons ranged from 1.0 to 2.9 at respective chlorine dioxide concentrations of 5 and 25 mg L-1, although spores were undetectable on the iron surface during disinfection at 25 mg L-1. Acidified nitrite (pH 2, 0.1 mol L-1) yielded no detectable spores on the iron surface during the flushing phase after disinfection. Chlorine dioxide was the best performing disinfectant with >3.0 log(10) removal from cement-mortar at 5 and 25 mg L-1. The data show that free chlorine, monochloramine, ozone and chlorine dioxide followed by flushing can reduce adhered spores by > 3.0 log(10) on cement-mortar. (C) 2016 Elsevier B.V. All rights reserved. C1 [Szabo, Jeffrey G.; Rice, Eugene W.; Hall, John] US EPA, Natl Homeland Secur Res Ctr, Water Infrastruct Protect Div, 26 W Martin Luther King Dr,MS NG 16, Cincinnati, OH 45268 USA. [Meiners, Greg; Heckman, Lee] CB&I Fed Serv LLC, 1600 Gest St, Cincinnati, OH 45204 USA. RP Szabo, JG (reprint author), US EPA, Natl Homeland Secur Res Ctr, Water Infrastruct Protect Div, 26 W Martin Luther King Dr,MS NG 16, Cincinnati, OH 45268 USA. EM szabo.jeff@epa.gov; greg.meiners@CBIFederalServices.com; heckman.lee@epa.gov; rice.gene@epa.gov; hall.john@epa.gov FU U.S. Environmental Protection Agency through its Office of Research and Development [EP-C-09-041] FX The U.S. Environmental Protection Agency through its Office of Research and Development partially funded and collaborated in the research described here under contract EP-C-09-041 to CB&I (formerly Shaw Environmental). It has been subjected to the Agency's review and has been approved for publication. Note that approval does not signify that the contents necessarily reflect the views of the Agency. Mention of trade names, products, or services does not convey official EPA approval, endorsement, or recommendation. NR 32 TC 0 Z9 0 U1 11 U2 11 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0301-4797 EI 1095-8630 J9 J ENVIRON MANAGE JI J. Environ. Manage. PD FEB 1 PY 2017 VL 187 BP 1 EP 7 DI 10.1016/j.jenvman.2016.11.024 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA EH8QN UT WOS:000392037500001 PM 27865123 ER PT J AU Gross, C Hagy, JD AF Gross, Catharine Hagy, James D., III TI Attributes of successful actions to restore lakes and estuaries degraded by nutrient pollution SO JOURNAL OF ENVIRONMENTAL MANAGEMENT LA English DT Article DE Watershed partnership; Multiple correspondence analysis; Ecological restoration; Nutrient pollution; Watershed management ID COLLABORATIVE WATERSHED MANAGEMENT; BOSTON HARBOR; TAMPA BAY; VENICE LAGOON; MORETON BAY; KANEOHE BAY; COASTAL EUTROPHICATION; AUSTRALIA IMPLICATIONS; ECOSYSTEM RESPONSES; LARGE DECREASES AB As more success is achieved in restoring lakes and estuaries from the impacts of nutrient pollution, there is increased opportunity to evaluate the scientific, social, and policy factors associated with achieving restoration goals. We examined case studies where deliberate actions to reduce nutrient pollution and restore ecosystems resulted in ecological recovery. Prospective cases were identified from scientific literature and technical documents for lakes and estuaries with: (1) scientific evidence of nutrient pollution; (2) restoration actions taken to mitigate nutrient pollution; and (3) documented ecological improvement. Using these criteria, we identified 9 estuaries and 7 lakes spanning countries, climatic regions, physical types, depths, and watershed areas. Among 16 case studies ultimately included, 8 achieved improvements short of stated restoration goals. Five more were successful initially, but condition subsequently declined. Three of the case studies achieved their goals fully and are currently managing to maintain the restored condition. We examined each case to identify both common attributes of nutrient management, grouped into 'themes', and variations on those attributes, which were coded into categorical variables based on thorough review of documents associated with each case. The themes and variables were organized into a broad conceptual model illustrating how they relate to each other and to nutrient management outcomes. We then explored relationships among the themes and variables using multiple correspondence analysis (MCA). Results of the MCA suggested that the attributes most associated with achieving restoration goals include: (1) leadership by a dedicated watershed management agency; (2) governance through a bottom-up collaborative process; (3) a strategy that set numeric targets based on a specific ecological goal; and (4) actions to reduce nutrient loads from all sources. While our study did not provide a comprehensive road map to successful nutrient management, it suggested attributes that could be emulated in future efforts. The quantitative approach that was applied could be used to provide ongoing analysis as new examples of nutrient management success emerge. Published by Elsevier Ltd. C1 [Gross, Catharine] US EPA, ORISE Res Participat Program, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA. [Hagy, James D., III] US EPA, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA. RP Hagy, JD (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA. EM hagy.jim@epa.gov FU US EPA Office of Research and Development's Safe and Sustainable Water Research Program FX The views expressed in this article are those of the authors and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency. This research was supported by the US EPA Office of Research and Development's Safe and Sustainable Water Research Program. Helpful comments on early drafts were provided by W. Nelson, C. Brown, L Ruiz-Green, B. Blackwell, M. Murrell, S. Bricker and two anonymous reviewers. Symbols used in the graphical abstract were provided courtesy of the Integration and Application Network, University of Maryland Center for Environmental Science (ian.umces.edu/symbols/). NR 149 TC 0 Z9 0 U1 25 U2 25 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0301-4797 EI 1095-8630 J9 J ENVIRON MANAGE JI J. Environ. Manage. PD FEB 1 PY 2017 VL 187 BP 122 EP 136 DI 10.1016/j.jenvman.2016.11.018 PG 15 WC Environmental Sciences SC Environmental Sciences & Ecology GA EH8QN UT WOS:000392037500015 PM 27886584 ER PT J AU Zhang, B Cao, C Hughes, RM Davis, WS AF Zhang, Bo Cao, Cong Hughes, Robert M. Davis, Wayne S. TI China's new environmental protection regulatory regime: Effects and gaps SO JOURNAL OF ENVIRONMENTAL MANAGEMENT LA English DT Review DE Air pollution; Water pollution; Law enforcement; Challenges ID FISH; INTEGRITY; WATERS; POLICY C1 [Zhang, Bo] Minist Environm Protect, Informat Ctr, Beijing, Peoples R China. [Cao, Cong] Univ Nottingham, Ningbo, Zhejiang, Peoples R China. [Hughes, Robert M.] Oregon State Univ, Amnis Opes Inst, Corvallis, OR 97331 USA. [Hughes, Robert M.] Oregon State Univ, Dept Fisheries & Wildlife, Corvallis, OR 97331 USA. [Davis, Wayne S.] US EPA, Washington, DC 20460 USA. RP Zhang, B (reprint author), Minist Environm Protect, Informat Ctr, Beijing, Peoples R China. EM zhangbo@mep.gov.cn NR 44 TC 0 Z9 0 U1 8 U2 8 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0301-4797 EI 1095-8630 J9 J ENVIRON MANAGE JI J. Environ. Manage. PD FEB 1 PY 2017 VL 187 BP 464 EP 469 DI 10.1016/j.jenvman.2016.11.009 PG 6 WC Environmental Sciences SC Environmental Sciences & Ecology GA EH8QN UT WOS:000392037500048 PM 27842725 ER PT J AU Ma, XM Lee, WH Lytle, DA AF Ma, Xiangmeng Lee, Woo Hyoung Lytle, Darren A. TI In situ 2D maps of pH shifts across brass-lead galvanic joints using microelectrodes SO MEASUREMENT SCIENCE AND TECHNOLOGY LA English DT Article DE corrosion; galvanic joints; in situ measurement; microelectrodes; 2D map ID NITRIFYING BIOFILM; SERVICE LINES; DRINKING-WATER; CORROSION; DEZINCIFICATION; RELEASE; PIPE; FLOW; DISINFECTION; PENETRATION AB Galvanic corrosion in drinking water distribution systems, such as conditions following partial lead service line replacement, can be a significant source of lead in tap water. The objective of this work was to measure the pH directly near metal surfaces using a novel experimental tool in order to understand the water chemistry at a lead-containing galvanic couple in drinking water. Specifically, pH microprofiles in the proximity of corroding metal surfaces were measured using a microelectrode to construct detailed in situ 2D spatial maps of the pH across a galvanic couple at 100 mu m above the metal's surface under flowing and stagnation conditions. The opposite pH trend was directly observed across the galvanic couple under flow and stagnation conditions. Water stagnation resulted in a pH at the anode (leaded solder) of 1.5 pH units lower than the bulk water pH (9.0) and as much as 2.5 pH units lower than the cathode (brass). These conditions can enhance lead release at the anode, which reflects different anodic-cathodic relationships of coupled metals primarily controlled by water flow. Most importantly, this work has demonstrated the ability to make real pH measurement at the surface of corroding metals using a novel microelectrode approach. C1 [Ma, Xiangmeng; Lee, Woo Hyoung] Univ Cent Florida, Dept Civil Environm & Construct Engn, Orlando, FL 32816 USA. [Lytle, Darren A.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Lee, Woo Hyoung] 12800 Pegasus Dr Suite 211, Orlando, FL 32816 USA. RP Lee, WH (reprint author), Univ Cent Florida, Dept Civil Environm & Construct Engn, Orlando, FL 32816 USA.; Lee, WH (reprint author), 12800 Pegasus Dr Suite 211, Orlando, FL 32816 USA. EM woohyoung.lee@ucf.edu NR 42 TC 0 Z9 0 U1 4 U2 4 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0957-0233 EI 1361-6501 J9 MEAS SCI TECHNOL JI Meas. Sci. Technol. PD FEB PY 2017 VL 28 IS 2 AR 025101 DI 10.1088/1361-6501/28/2/025101 PG 10 WC Engineering, Multidisciplinary; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA EH3HB UT WOS:000391661600001 ER PT J AU Flynn, K Swintek, J Johnson, R AF Flynn, Kevin Swintek, Joe Johnson, Rodney TI The influence of control group reproduction on the statistical power of the Environmental Protection Agency's Medaka Extended One Generation Reproduction Test (MEOGRT) SO ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY LA English DT Article DE Statistical power; MEOGRT; Risk assessment; Study design AB Because of various Congressional mandates to protect the environment from endocrine disrupting chemicals (EDCs), the United States Environmental Protection Agency (USEPA) initiated the Endocrine Disruptor Screening Program. In the context of this framework, the Office of Research and Development within the USEPA developed the Medaka Extended One Generation Reproduction Test (MEOGRT) to characterize the endocrine action of a suspected EDC. One important endpoint of the MEOGRT is fecundity of medaka breeding pairs. Power analyses were conducted to determine the number of replicates needed in proposed test designs and to determine the effects that varying reproductive parameters (e.g. mean fecundity, variance, and days with no egg production) would have on the statistical power of the test. The MEOGRT Reproduction Power Analysis Tool (MRPAT) is a software tool developed to expedite these power analyses by both calculating estimates of the needed reproductive parameters (e.g. population mean and variance) and performing the power analysis under user specified scenarios. Example scenarios are detailed that highlight the importance of the reproductive parameters on statistical power. When control fecundity is increased from 21 to 38 eggs per pair per day and the variance decreased from 49 to 20, the gain in power is equivalent to increasing replication by 2.5 times. On the other hand, if 10% of the breeding pairs, including controls, do not spawn, the power to detect a 40% decrease in fecundity drops to 0.54 from nearly 0.98 when all pairs have some level of egg production. Perhaps most importantly, MRPAT was used to inform the decision making process that lead to the final recommendation of the MEOGRT to have 24 control breeding pairs and 12 breeding pairs in each exposure group. C1 [Flynn, Kevin; Johnson, Rodney] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA. [Swintek, Joe] Badger Tech Serv, Duluth, MN USA. RP Flynn, K (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA. EM flynn.kevin@epa.gov FU US Environmental Protection Agency FX The research described in this document has been funded wholly by the US Environmental Protection Agency. NR 12 TC 0 Z9 0 U1 9 U2 9 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0147-6513 EI 1090-2414 J9 ECOTOX ENVIRON SAFE JI Ecotox. Environ. Safe. PD FEB PY 2017 VL 136 BP 8 EP 13 DI 10.1016/j.ecoenv.2016.10.024 PG 6 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA EG3XI UT WOS:000390977600002 PM 27810580 ER PT J AU Kohut, JT Kustka, AB Hiscock, MR Lam, PJ Measures, C Milligan, A White, A Carvalho, F Hatta, M Jones, BM Ohnemus, DC Swartz, JM AF Kohut, Josh T. Kustka, Adam B. Hiscock, Michael R. Lam, Phoebe J. Measures, Chris Milligan, Allen White, Angelicque Carvalho, Filipa Hatta, Mariko Jones, Bethan M. Ohnemus, Daniel C. Swartz, John M. TI Mesoscale variability of the summer bloom over the northern Ross Sea shelf: A tale of two banks SO JOURNAL OF MARINE SYSTEMS LA English DT Article DE Ross Sea; Phytoplankton; Trace metals; Mixed layers; Light and iron limitation; Bathymetry ID PHYTOPLANKTON GROWTH; SOUTHERN-OCEAN; FRAGILARIOPSIS-CYLINDRUS; PHAEOCYSTIS-ANTARCTICA; BAROTROPIC TIDES; IRON LIMITATION; PHOTOPHYSIOLOGY; ECOLOGY; SIZE; ICE AB Multi-year satellite records indicate an asymmetric spatial pattern in the summer bloom in the Northern Ross Sea, with the largest blooms over the shallows of Pennell Bank compared to Mawson Bank. In 2010-2011, high-resolution spatiotemporal in situ sampling focused on these two banks to better understand factors contributing to this pattern. Dissolved and particulate Fe profiles suggested similar surface water depletion of dissolved Fe on both banks. The surface sediments and velocity observations indicate a more energetic water column over Mawson Bank. Consequently, the surface mixed layer over Pennell Bank was more homogeneous and shallower. Over Mawson Bank we observed a thicker more homogeneous bottom boundary layer resulting from stronger tidal and sub-tidal currents. These stronger currents scour the seafloor resulting in sediments less likely to release additional sedimentary iron. Estimates of the quantum yield of photosynthesis and the initial slope of the photosynthesis-irradiance response were lower over Mawson Bank, indicating higher iron stress over Mawson Bank. Overall, the apparent additional sedimentary source of iron to, and longer surface residence time over Pennell Bank, as well as the reduced fluxes from the more isolated bottom mixed layer over Mawson Bank, sustain the observed asymmetric pattern across both banks. (C) 2016 Published by Elsevier B.V. C1 [Kohut, Josh T.; Carvalho, Filipa] Rutgers State Univ, Dept Marine & Coastal Sci, New Brunswick, NJ 08901 USA. [Kustka, Adam B.; Jones, Bethan M.] Rutgers State Univ, Dept Earth & Environm Sci, Newark, NJ 07102 USA. [Hiscock, Michael R.] US EPA, Natl Ctr Environm Res, Washington, DC 20460 USA. [Lam, Phoebe J.; Ohnemus, Daniel C.; Swartz, John M.] Woods Hole Oceanog Inst, Dept Marine Chem & Geochem, Woods Hole, MA 02543 USA. [Lam, Phoebe J.] Univ Calif Santa Cruz, Dept Ocean Sci, Santa Cruz, CA 95064 USA. [Measures, Chris; Hatta, Mariko] Univ Hawaii, Dept Oceanog, Honolulu, HI 96822 USA. [Milligan, Allen; Jones, Bethan M.] Oregon State Univ, Dept Bot & Plant Pathol, Corvallis, OR 97331 USA. [White, Angelicque] Oregon State Univ, Coll Earth Ocean & Atmospher Sci, Corvallis, OR 97331 USA. [Ohnemus, Daniel C.] Bigelow Lab Ocean Sci, East Boothbay, ME 04544 USA. [Swartz, John M.] Univ Texas Austin, Inst Geophys, Jackson Sch Geosci, Austin, TX 78758 USA. RP Kohut, JT (reprint author), Rutgers State Univ, Dept Marine & Coastal Sci, New Brunswick, NJ 08901 USA. EM kohut@marine.rutgers.edu OI Carvalho, Filipa/0000-0002-8355-4329 FU NSF Office of Polar Programs [ANT 0839039, ANT-0839024, ANT-0838921] FX The NSF Office of Polar Programs supported the Slocum Enhanced Adaptive Fe Algal Research in the Ross Sea (SEAFAReRS) project (ANT 0839039 to Kohut, Kustka, Milligan, and White; ANT-0839024 to Measures; and ANT-0838921 to Lam). We would also like to thank the entire crew of the RVIB Nathaniel B. Palmer for their support throughout the cruise and the Raytheon Polar Services personnel for logistical assistance. In addition, we are grateful to John Kerfoot (Rutgers) for the glider processing before and after the deployment and to Robert Chant and Eli Hinter for their insight and guidance. We would also like to thank the two anonymous reviewers whose helpful critique contributed to the final version of the manuscript. This article was prepared while Hiscock was employed at Princeton University. The opinions expressed in this article are the author's own and do not necessarily represent the views or policies of the U.S. Environmental Protection Agency. NR 49 TC 2 Z9 2 U1 7 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0924-7963 EI 1879-1573 J9 J MARINE SYST JI J. Mar. Syst. PD FEB PY 2017 VL 166 BP 50 EP 60 DI 10.1016/j.jmarsys.2016.06.009 PG 11 WC Geosciences, Multidisciplinary; Marine & Freshwater Biology; Oceanography SC Geology; Marine & Freshwater Biology; Oceanography GA EG5HG UT WOS:000391074300005 ER PT J AU Pickard, BR Nash, M Baynes, J Mehaffey, M AF Pickard, Brian R. Nash, Maliha Baynes, Jeremy Mehaffey, Megan TI Planning for community resilience to future United States domestic water demand SO LANDSCAPE AND URBAN PLANNING LA English DT Article DE Water demand; Climate; Sustainability; Resilience ID CLIMATE-CHANGE; RESOURCES; ECOREGIONS; WITHDRAWAL; SCENARIOS AB Costs of repairing and expanding aging infrastructure and competing demands for water from other sectors such as industry and agriculture are stretching water managers' abilities to meet essential domestic drinking water needs for future generations. Using Bayesian statistical modeling on past and present water use, we project domestic water demand in the context of four climate scenarios developed by the Intergovernmental Panel on Climate Change as part of the their Special Report on Emission Scenarios (SRES). We compare 2010 demand to projections of domestic water demand for the years 2030, 2060 and 2090 for the four SRES scenarios. Results indicate that the number of counties exceeding fifty percent or greater demand over 2010 levels increases through 2090 for two of the scenarios and plateaus around 2050 for the other two. Counties experiencing the largest increases in water demand are concentrated in the states of California, Texas, and isolated portions of the Mid-West, Southeast, and Mid-Atlantic. Closer examination of the spatial distribution of high demand counties reveals that they are typically found near or adjacent to metropolitan centers, potentially placing greater stress on already taxed systems. Identifying these counties allows for targeted adaptive management and policies, economic incentives, and legislation to be focused towards locations that are potentially the most vulnerable. Published by Elsevier B.V. C1 [Pickard, Brian R.; Baynes, Jeremy] US EPA, Off Res & Dev, Oak Ridge Inst Sci & Educ, Durham, NC USA. [Nash, Maliha; Mehaffey, Megan] US EPA, Off Res & Dev, Natl Exposure Res Lab, Durham, NC 27709 USA. RP Mehaffey, M (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, Durham, NC 27709 USA. EM mehaffey.megan@epa.gov FU U.S. Environmental Protection Agency (EPA), Office of Research and Development FX This project was supported in part by an appointment to the Research Participation Program for the U.S. Environmental Protection Agency (EPA), Office of Research and Development, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and EPA. The views expressed in this article are those of the authors and do not necessarily reflect the views or policies of the EPA. The authors would like to thank the two anonymous reviewers for their critical review of this manuscript. NR 31 TC 0 Z9 0 U1 50 U2 50 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-2046 EI 1872-6062 J9 LANDSCAPE URBAN PLAN JI Landsc. Urban Plan. PD FEB PY 2017 VL 158 BP 75 EP 86 DI 10.1016/j.landurbplan.2016.07.014 PG 12 WC Ecology; Environmental Studies; Geography; Geography, Physical; Urban Studies SC Environmental Sciences & Ecology; Geography; Physical Geography; Urban Studies GA EF1HO UT WOS:000390076100007 ER PT J AU Galmarini, S Koffi, B Solazzo, E Keating, T Hogrefe, C Schulz, M Benedictow, A Griesfeller, JJ Janssens-Maenhout, G Carmichael, G Fu, J Dentener, F AF Galmarini, Stefano Koffi, Brigitte Solazzo, Efisio Keating, Terry Hogrefe, Christian Schulz, Michael Benedictow, Anna Griesfeller, Jan Jurgen Janssens-Maenhout, Greet Carmichael, Greg Fu, Joshua Dentener, Frank TI Technical note: Coordination and harmonization of the multi-scale, multi-model activities HTAP2, AQMEII3, and MICS-Asia3: simulations, emission inventories, boundary conditions, and model output formats SO ATMOSPHERIC CHEMISTRY AND PHYSICS LA English DT Article ID TROPOSPHERIC CHEMISTRY; TRANSPORT; SYSTEM AB We present an overview of the coordinated global numerical modelling experiments performed during 20122016 by the Task Force on Hemispheric Transport of Air Pollution (TF HTAP), the regional experiments by the Air Quality Model Evaluation International Initiative (AQMEII) over Europe and North America, and the Model Intercomparison Study for Asia (MICS-Asia). To improve model estimates of the impacts of intercontinental transport of air pollution on climate, ecosystems, and human health and to answer a set of policy-relevant questions, these three initiatives performed emission perturbation modelling experiments consistent across the global, hemispheric, and continental/regional scales. In all three initiatives, model results are extensively compared against monitoring data for a range of variables (meteorological, trace gas concentrations, and aerosol mass and composition) from different measurement platforms (ground measurements, vertical profiles, airborne measurements) collected from a number of sources. Approximately 10 to 25 modelling groups have contributed to each initiative, and model results have been managed centrally through three data hubs maintained by each initiative. Given the organizational complexity of bringing together these three initiatives to address a common set of policy-relevant questions, this publication provides the motivation for the modelling activity, the rationale for specific choices made in the model experiments, and an overview of the organizational structures for both the modelling and the measurements used and analysed in a number of modelling studies in this special issue. C1 [Galmarini, Stefano; Koffi, Brigitte; Solazzo, Efisio; Janssens-Maenhout, Greet; Dentener, Frank] European Commiss, Joint Res Ctr, Ispra, Italy. [Keating, Terry] US EPA, Appl Sci & Educ Div, Natl Ctr Environm Res, Off Res & Dev, Washington, DC 20460 USA. [Hogrefe, Christian] US EPA, Computat Exposure Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Schulz, Michael; Benedictow, Anna; Griesfeller, Jan Jurgen] Norwegian Meteorol Inst, Oslo, Norway. [Carmichael, Greg] Univ Iowa, Ctr Global & Reg Environm Res, Iowa City, IA 52242 USA. [Fu, Joshua] Univ Tennessee, Dept Civil & Environm Engn, Knoxville, TN 37996 USA. RP Galmarini, S (reprint author), European Commiss, Joint Res Ctr, Ispra, Italy. EM stefano.galmarini@jrc.ec.europa.eu FU CLRTAP under the EMEP programme [07.0307/2011/605671/SER/C3]; Research Council of Norway [229796]; Administrative Arrangement AMITO; AMITO2 from the European Commission DG Environment FX The AeroCom database at MetNo received support from the CLRTAP under the EMEP programme, through the service contract to the European commission no. 07.0307/2011/605671/SER/C3, and benefitted from the Research Council of Norway project no. 229796 (AeroCom-P3). JRC received support for this work via Administrative Arrangement AMITO and AMITO2 from the European Commission DG Environment. TF HTAP, AeroCom, AQMEII, and MICS-Asia exist due to the relentless contributions of numerous excellent scientists actively engaged in the individual activities as well as in the wider TF programme. Although this work has been reviewed and approved for publication by the US Environmental Protection Agency, it does not necessarily reflect the views and policies of the agency. We thank Mian Chin for her support in designing and promoting the HTAP-AEROCOM experiments. NR 29 TC 1 Z9 1 U1 0 U2 0 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1680-7316 EI 1680-7324 J9 ATMOS CHEM PHYS JI Atmos. Chem. Phys. PD JAN 31 PY 2017 VL 17 IS 2 BP 1543 EP 1555 DI 10.5194/acp-17-1543-2017 PG 13 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA EL4SH UT WOS:000394610700008 ER PT J AU Zhou, PT Ganzeveld, L Rannik, U Zhou, LX Gierens, R Taipale, D Mammarella, I Boy, M AF Zhou, Putian Ganzeveld, Laurens Rannik, Ullar Zhou, Luxi Gierens, Rosa Taipale, Ditte Mammarella, Ivan Boy, Michael TI Simulating ozone dry deposition at a boreal forest with a multi-layer canopy deposition model SO ATMOSPHERIC CHEMISTRY AND PHYSICS LA English DT Article ID GENERAL-CIRCULATION MODEL; PINE FOREST; SULFURIC-ACID; SCOTS PINE; AEROSOL DYNAMICS; ATMOSPHERIC OH; ORGANIC VAPORS; FLUXES; CHEMISTRY; ECOSYSTEM AB A multi-layer ozone (O-3) dry deposition model has been implemented into SOSAA (a model to Simulate the concentrations of Organic vapours, Sulphuric Acid and Aerosols) to improve the representation of O-3 concentration and flux within and above the forest canopy in the planetary boundary layer. We aim to predict the O-3 uptake by a boreal forest canopy under varying environmental conditions and analyse the influence of different factors on total O-3 uptake by the canopy as well as the vertical distribution of deposition sinks inside the canopy. The newly implemented dry deposition model was validated by an extensive comparison of simulated and observed O-3 turbulent fluxes and concentration profiles within and above the boreal forest canopy at SMEAR II (Station to Measure Ecosystem-Atmosphere Relations II) in Hyytiala, Finland, in August 2010. In this model, the fraction of wet surface on vegetation leaves was parametrised according to the ambient relative humidity (RH). Model results showed that when RH was larger than 70% the O-3 uptake onto wet skin contributed similar to 51% to the total deposition during nighttime and similar to 19% during daytime. The overall contribution of soil uptake was estimated about 36 %. The contribution of sub-canopy deposition below 4.2m was modelled to be similar to 38% of the total O-3 deposition during daytime, which was similar to the contribution reported in previous studies. The chemical contribution to O-3 removal was evaluated directly in the model simulations. According to the simulated averaged diurnal cycle the net chemical production of O-3 compensated up to similar to 4% of dry deposition loss from about 06:00 to 15:00 LT. During nighttime, the net chemical loss of O-3 further enhanced removal by dry deposition by a maximum similar to 9 %. Thus the results indicated an overall relatively small contribution of airborne chemical processes to O-3 removal at this site. C1 [Zhou, Putian; Rannik, Ullar; Zhou, Luxi; Gierens, Rosa; Mammarella, Ivan; Boy, Michael] Univ Helsinki, Dept Phys, POB 64, Helsinki 00014, Finland. [Ganzeveld, Laurens] Univ Wageningen & Res Ctr, Dept Environm Sci, Meteorol & Air Qual, Wageningen, Netherlands. [Taipale, Ditte] Univ Helsinki, Dept Forest Sci, POB 27, Helsinki 00014, Finland. [Taipale, Ditte] Estonian Univ Life Sci, Dept Plant Physiol, EE-51014 Kreutzwaldi 1, Estonia. [Zhou, Luxi] US EPA, Res Triangle Pk, NC 27711 USA. [Gierens, Rosa] Univ Cologne, Inst Geophys & Meteorol, Cologne, Germany. RP Zhou, PT (reprint author), Univ Helsinki, Dept Phys, POB 64, Helsinki 00014, Finland. EM putian.zhou@helsinki.fi OI Taipale, Ditte/0000-0002-2023-2461; Boy, Michael/0000-0002-8107-4524; Mammarella, Ivan/0000-0002-8516-3356; Zhou, Putian/0000-0003-0803-7337 FU Maj ja Tor Nessling; Academy of Finland [1118615, 272041]; CRAICC (Cryosphere-atmosphere interactions in a changing Arctic climate); eSTICC (eScience tools for investigating Climate Change in Northern High Latitudes); FCoE (The Centre of Excellence in Atmospheric Science - From Molecular and Biological processes to The Global Climate); Estonian Ministry of Education and Research [IUT20-11]; European Regional Development Fund (Centre of Excellence EcolChange) FX This work was supported by Maj ja Tor Nessling funding, the Academy of Finland (projects 1118615 and 272041), CRAICC (Cryosphere-atmosphere interactions in a changing Arctic climate), eSTICC (eScience tools for investigating Climate Change in Northern High Latitudes) and FCoE (The Centre of Excellence in Atmospheric Science - From Molecular and Biological processes to The Global Climate). This work was also supported by institutional research funding (IUT20-11) of the Estonian Ministry of Education and Research, and the European Regional Development Fund (Centre of Excellence EcolChange). The authors also wish to acknowledge CSC - IT Center for Science, Finland, for computational resources. NR 53 TC 0 Z9 0 U1 0 U2 0 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1680-7316 EI 1680-7324 J9 ATMOS CHEM PHYS JI Atmos. Chem. Phys. PD JAN 30 PY 2017 VL 17 IS 2 BP 1361 EP 1379 DI 10.5194/acp-17-1361-2017 PG 19 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA EL4QP UT WOS:000394606200004 ER PT J AU Conmy, RN Schaeffer, BA Schubauer-Berigan, J Aukamp, J Duffy, A Lehrter, JC Greene, RM AF Conmy, Robyn N. Schaeffer, Blake A. Schubauer-Berigan, Joseph Aukamp, Jessica Duffy, Allyn Lehrter, John C. Greene, Richard M. TI Characterizing light attenuation within Northwest Florida Estuaries: Implications for RESTORE Act water quality monitoring SO MARINE POLLUTION BULLETIN LA English DT Article DE Deepwater Horizon oil spill; RESTORE Act; Northwest Florida Estuaries; Water quality & clarity; Light attenuation ID DISSOLVED ORGANIC-MATTER; HORIZON OIL-SPILL; COASTAL WATERS; RIVER; PHYTOPLANKTON; ABSORPTION; CARBON; OCEAN; ENVIRONMENTS; FLUORESCENCE AB Water Quality (WQ) condition is based on ecosystem stressor indicators (e.g. water clarity) which are biogeochemically important and critical when considering the Deepwater Horizon oil spill restoration efforts under the 2012 RESTORE Act. Nearly all of the proposed RESTORE projects list restoring WC as a goal, but 90% neglect water clarity. Here, dynamics of optical constituents impacting clarity are presented from a 2009-2011 study within Pensacola, Choctawhatchee, St. Andrew and St Joseph estuaries (targeted RESTORE sites) in Northwest Florida. Phytoplankton were the smallest contribution to total absorption (a(t-w)PAR) at 412 nm (5-11%), whereas colored dissolved organic matter was the largest (61-79%). Estuarine a(t-w)PAR was significantly related to light attenuation (K(d)PAR), where individual contributors to clarity and the influence of climatic events were discerned. Provided are conversion equations demonstrating interoperability of clarity indicators between traditional State-measured WQ measures (e.g. secchi disc), optical constituents, and even satellite remote sensing for obtaining baseline assessments. Published by Elsevier Ltd. C1 [Conmy, Robyn N.; Schubauer-Berigan, Joseph] US EPA, Off Res & Dev, NRMRL Land Remediat & Pollut Control Div, 26 W MLK Dr, Cincinnati, OH 45268 USA. [Schaeffer, Blake A.] US EPA, Off Res & Dev, NERL Exposure Methods & Measurement Div, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. [Aukamp, Jessica; Duffy, Allyn; Lehrter, John C.; Greene, Richard M.] US EPA, Off Res & Dev, NHEERL Gulf Ecol Div, 1 Sabine, Gulf Breeze, FL 32561 USA. RP Conmy, RN (reprint author), US EPA, Off Res & Dev, NRMRL Land Remediat & Pollut Control Div, 26 W MLK Dr, Cincinnati, OH 45268 USA. EM conmy.robyn@epa.gov FU NASA Applied Sciences Program; U.S. Environmental Protection Agency Office of Research and Development FX The authors would like to thank NASA Applied Sciences Program for financial support of this work. The information in this document has been partially funded by the U.S. Environmental Protection Agency Office of Research and Development. It has been subjected to quality assurance and peer review by the National Risk Management Research Laboratory (NRMRL) and approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. This a contribution of the EPA NRMRL Land Remediation and Pollution Control Division and the National Health and Environmental Effects (NHEERL) Gulf Ecology Division. Additional thanks to EPA staff Dianne Yates for data management, George Craven for boat operation, James Hagy for sensor processing and Michael Murrell for field logistics. For more details on the RESTORE Act and the Council go to www.restorethegulf.gov. NR 65 TC 0 Z9 0 U1 4 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0025-326X EI 1879-3363 J9 MAR POLLUT BULL JI Mar. Pollut. Bull. PD JAN 30 PY 2017 VL 114 IS 2 BP 995 EP 1006 DI 10.1016/j.marpolbul.2016.11.030 PG 12 WC Environmental Sciences; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA EK4XR UT WOS:000393931700042 PM 27876374 ER PT J AU Brack, W Dulio, V Aring;gerstrand, M Allan, I Altenburger, R Brinkmann, M Bunke, D Burgess, RM Cousins, I Escher, BI Hernandez, FJ Hewitt, LM Hilscherova, K Hollender, J Hollert, H Kase, R Klauer, B Lindim, C Herraez, DL Miege, C Munthe, J O'Toole, S Posthuma, L Rudel, H Schafer, RB Sengl, M Smedes, F van de Meent, D van den Brink, PJ van Gils, J van Wezel, AP Vethaak, AD Vermeirssen, E von der Ohe, PC Vrana, B AF Brack, Werner Dulio, Valeria Agerstrand, Marlene Allan, Ian Altenburger, Rolf Brinkmann, Markus Bunke, Dirk Burgess, Robert M. Cousins, Ian Escher, Beate I. Hernandez, Felix J. Hewitt, L. Mark Hilscherova, Klara Hollender, Juliane Hollert, Henner Kase, Robert Klauer, Bernd Lindim, Claudia Herraez, David Lopez Miege, Cecil Munthe, John O'Toole, Simon Posthuma, Leo Ruedel, Heinz Schaefer, Ralf B. Sengl, Manfred Smedes, Foppe van de Meent, Dik van den Brink, Paul J. van Gils, Jos van Wezel, Annemarie P. Vethaak, A. Dick Vermeirssen, Etienne von der Ohe, Peter C. Vrana, Branislav TI Towards the review of the European Union Water Framework Directive: Recommendations for more efficient assessment and management of chemical contamination in European surface water resources SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Review ID SAFE OPERATING SPACE; IN-VITRO BIOASSAYS; BASIN SPECIFIC POLLUTANTS; PASSIVE SAMPLING METHODS; QUALITY TRIGGER VALUES; ORGANIC CONTAMINANTS; RISK-ASSESSMENT; AQUATIC INVERTEBRATE; CONCEPTUAL-FRAMEWORK; ECOLOGICAL STATUS AB Water is a vital resource for natural ecosystems and human life, and assuring a high quality of water and protecting it from chemical contamination is a major societal goal in the European Union. The Water Framework Directive (WFD) and its daughter directives are the major body of legislation for the protection and sustainable use of European freshwater resources. The practical implementation of the WFD with regard to chemical pollution has faced some challenges. In support of the upcoming WFD review in 2019 the research project SOLUTIONS and the European monitoring network NORMAN has analyzed these challenges, evaluated the state-of-the-art of the science and suggested possible solutions. We give 10 recommendations to improve monitoring and to strengthen comprehensive prioritization, to foster consistent assessment and to support solution-oriented management of surface waters. The integration of effect-based tools, the application of passive sampling for bioaccumulative chemicals and an integrated strategy for prioritization of contaminants, accounting for knowledge gaps, are seen as important approaches to advance monitoring. Including all relevant chemical contaminants in more holistic "chemical status" assessment, using effect-based trigger values to address priority mixtures of chemicals, to better consider historical burdens accumulated in sediments and to use models to fill data gaps are recommended for a consistent assessment of contamination. Solution-oriented management should apply a tiered approach in investigative monitoring, to identify toxicity drivers, strengthen consistent legislative frameworks and apply solutions-oriented approaches that explore risk reduction scenarios before and along with risk assessment. (C) 2016 Published by Elsevier B.V. C1 [Brack, Werner; Altenburger, Rolf; Escher, Beate I.; Klauer, Bernd; Herraez, David Lopez; van Wezel, Annemarie P.; Vethaak, A. Dick; von der Ohe, Peter C.] UFZ Helmholtz Ctr Environm Res, Leipzig, Germany. [Brack, Werner; Altenburger, Rolf; Brinkmann, Markus; Hollert, Henner] Rhein Westfal TH Aachen, Aachen, Germany. [Dulio, Valeria] Inst Natl Environm Ind & Risques INERIS, Verneuil En Halatte, France. [Agerstrand, Marlene; Cousins, Ian; Lindim, Claudia] Stockholm Univ, ACES Dept Environm Sci & Analyt Chem, Stockholm, Sweden. [Allan, Ian] Norwegian Inst Water Res NIVA, Oslo, Norway. [Bunke, Dirk] Oeko Inst eV, Inst Appl Ecol, Freiburg, Germany. [Burgess, Robert M.] US EPA, ORD, NHEERL, Atlantic Ecol Div, Narragansett, RI USA. [Escher, Beate I.] Eberhard Karts Univ Tubingen, Tubingen, Germany. [Hernandez, Felix J.] Jaume I Univ, Castellon de La Plana, Spain. [Hewitt, L. Mark] Environm Canada, Aquat Ecosyst Protect Res Div, Burlington, ON, Canada. [Hilscherova, Klara; Smedes, Foppe; Vrana, Branislav] Masaryk Univ, Res Ctr Toxic Cpds Environm RECETOX, Brno, Czech Republic. [Hollender, Juliane; Vermeirssen, Etienne] EAWAG, Swiss Fed Inst Aquat Sci & Technol, Dubendorf, Switzerland. [Kase, Robert] Eawag EPFL, Swiss Ctr Appl Ecotoxicol, Dubendorf, Switzerland. [Miege, Cecil] IRSTEA, OR MALY, Villeurbanne, France. [Munthe, John] IVL Swedish Environm Res Inst, Gothenburg, Sweden. [O'Toole, Simon] Environm Protect Agcy, Dublin, Ireland. [Posthuma, Leo] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands. [Posthuma, Leo] Radboud Univ Nijmegen, Inst Water & Wetland Res, Dept Environm Sci, Nijmegen, Netherlands. [Ruedel, Heinz] Fraunhofer Inst Mol Biol & Appl Ecol IME, Aberg 1, D-57392 Schmallenberg, Germany. [Schaefer, Ralf B.] Univ Koblenz Landau, Landau, Germany. [Sengl, Manfred] Bavarian Environm Agcy, D-86179 Augsburg, Germany. [van de Meent, Dik] MERMAYDE, Groet, Netherlands. [van den Brink, Paul J.] Wageningen Univ & Res Ctr, Alterra, POB 47, NL-6700 AA Wageningen, Netherlands. [van den Brink, Paul J.] Wageningen Univ & Res Ctr, Dept Aquat Ecol & Water Qual Management, POB 47, NL-6700 AA Wageningen, Netherlands. [van Gils, Jos; Vethaak, A. Dick] Deltares, Delft, Netherlands. [van Wezel, Annemarie P.] KWR Watercycle Res Inst, Nieuwegein, Netherlands. [van Wezel, Annemarie P.] Univ Utrecht, Copernicus Inst, Utrecht, Netherlands. [Vethaak, A. Dick] Vrije Univ Amsterdam, Inst Environm Studies, Amsterdam, Netherlands. [von der Ohe, Peter C.] Amalex Environm Solut, Leipzig, Germany. RP Brack, W (reprint author), UFZ Helmholtz Ctr Environm Res, Leipzig, Germany. EM werner.brack@ufz.de RI Cousins, Ian/A-6944-2008; Escher, Beate/C-7992-2009; Klauer, Bernd/A-6304-2012; van de Meent, Dik/C-3982-2011; Hollender, Juliane/A-2145-2014 OI Cousins, Ian/0000-0002-7035-8660; Escher, Beate/0000-0002-5304-706X; Hollender, Juliane/0000-0002-4660-274X FU SOLUTIONS project (European Union's Seventh Framework Programme for research, technological development and demonstration) [603437]; NORMAN network FX This article has been supported by, and prepared as a common outcome of the NORMAN network (www.norman-network.net) on emerging pollutants and the SOLUTIONS project (European Union's Seventh Framework Programme for research, technological development and demonstration under grant agreement no. 603437). Andreas Kortenkamp, University of Brunel, is acknowledged for proof reading. The views expressed herein do not necessarily reflect the views or policies of the authors' agencies. Bo N. Jacobsen and Giordano Giorgi are acknowledged for their comments. NR 142 TC 2 Z9 2 U1 53 U2 53 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD JAN 15 PY 2017 VL 576 BP 720 EP 737 DI 10.1016/j.scitotenv.2016.10.104 PG 18 WC Environmental Sciences SC Environmental Sciences & Ecology GA EG3SJ UT WOS:000390964700069 PM 27810758 ER PT J AU Su, CM AF Su, Chunming TI Environmental implications and applications of engineered nanoscale magnetite and its hybrid nanocomposites: A review of recent literature SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Review DE Fe3O4; Hybrid nanocomposites; Superparamagnetic; Catalyst; Remediation ID IRON-OXIDE NANOPARTICLES; ZERO-VALENT IRON; MULTIWALLED CARBON NANOTUBES; CORE-SHELL NANOPARTICLES; ATOMIC-ABSORPTION-SPECTROMETRY; ONE-POT SYNTHESIS; LIGHT-DRIVEN PHOTOCATALYSTS; CROSS-COUPLING REACTIONS; SATURATED POROUS-MEDIA; SOLID-PHASE EXTRACTION AB This review focuses on environmental implications and applications of engineered magnetite (Fe3O4) nanoparticles (MNPs) as a single phase or a compbnent of a hybrid nanocomposite that exhibits superparamagnetism and high surface area. MNPs are synthesized via co-precipitation, thermal decomposition and combustion, hydrothermal process, emulsion, microbial process, and green approaches. Aggregation/sedimentation and transport of MNPs depend on surface charge of MNPs and geochemical parameters such as pH, ionic strength, and organic matter. MNPs generally have low toxicity to humans and ecosystem. MNPs are used for constructing chemical/biosensors and for catalyzing a variety of chemical reactions. MNPs are used for air cleanup and carbon sequestration. MNP nanocomposites are designed as antimicrobial agents for water disinfection and flocculants for water treatment. Conjugated MNPs are widely used for adsorptive/separative removal of organics, dyes, oil, arsenic, phosphate, molybdate, fluoride, selenium, Cr(VI), heavy metal cations, radionuclides, and rare earth elements. MNPs can degrade organic/inorganic contaminants via chemical reduction or catalyze chemical oxidation in water, sediment, and soil. Future studies should further explore mechanisms of MNP interactions with other nanomaterials and contaminants, economic and green approaches of MNP synthesis, and field scale demonstration of MNP utilization. Published by Elsevier B.V. C1 [Su, Chunming] US EPA, Ground Water & Ecosyst Restorat Div, Natl Risk Management Res Lab, Off Res & Dev, 919 Kerr Res Dr, Ada, OK 74820 USA. RP Su, CM (reprint author), US EPA, Ground Water & Ecosyst Restorat Div, Natl Risk Management Res Lab, Off Res & Dev, 919 Kerr Res Dr, Ada, OK 74820 USA. EM su.chunming@epa.gov FU U.S. Environmental Protection Agency through its Office of Research and Development FX The work upon which this paper is based was supported by the U.S. Environmental Protection Agency through its Office of Research and Development. This work has not been subjected to agency review and, therefore, doesn't necessarily reflect the views of the agency and no official endorsement should be inferred. Any product or trade name mentioned here is for information purposes only and not to constitute endorsement. NR 407 TC 2 Z9 2 U1 269 U2 269 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 EI 1873-3336 J9 J HAZARD MATER JI J. Hazard. Mater. PD JAN 15 PY 2017 VL 322 SI SI BP 48 EP 84 DI 10.1016/j.jhazmat.2016.06.060 PN A PG 37 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA EC3XU UT WOS:000388061200005 PM 27477792 ER PT J AU Melvin, AM Larsen, P Boehlert, B Neumann, JE Chinowsky, P Espinet, X Martinich, J Baumann, MS Rennels, L Bothner, A Nicolsky, DJ Marchenko, SS AF Melvin, April M. Larsen, Peter Boehlert, Brent Neumann, James E. Chinowsky, Paul Espinet, Xavier Martinich, Jeremy Baumann, Matthew S. Rennels, Lisa Bothner, Alexandra Nicolsky, Dmitry J. Marchenko, Sergey S. TI Climate change damages to Alaska public infrastructure and the economics of proactive adaptation SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE Alaska; climate change; damages; adaptation; infrastructure ID THAW SETTLEMENT; BOREAL FORESTS; COASTAL-PLAIN; ACTIVE LAYER; FIRE REGIME; PERMAFROST; VULNERABILITY; MODEL; REGIONS; HAZARD AB Climate change in the circumpolar region is causing dramatic environmental change that is increasing the vulnerability of infrastructure. We quantified the economic impacts of climate change on Alaska public infrastructure under relatively high and low climate forcing scenarios [representative concentration pathway 8.5 (RCP8.5) and RCP4.5] using an infrastructure model modified to account for unique climate impacts at northern latitudes, including near-surface permafrost thaw. Additionally, we evaluated how proactive adaptation influenced economic impacts on select infrastructure types and developed first-order estimates of potential land losses associated with coastal erosion and lengthening of the coastal ice-free season for 12 communities. Cumulative estimated expenses from climate-related damage to infrastructure without adaptation measures (hereafter damages) from 2015 to 2099 totaled $5.5 billion (2015 dollars, 3% discount) for RCP8.5 and $4.2 billion for RCP4.5, suggesting that reducing greenhouse gas emissions could lessen damages by $1.3 billion this century. The distribution of damages varied across the state, with the largest damages projected for the interior and southcentral Alaska. The largest source of damages was road flooding caused by increased precipitation followed by damages to buildings associated with near-surface permafrost thaw. Smaller damages were observed for airports, railroads, and pipelines. Proactive adaptation reduced total projected cumulative expenditures to $2.9 billion for RCP8.5 and $2.3 billion for RCP4.5. For road flooding, adaptation provided an annual savings of 80-100% across four study eras. For nearly all infrastructure types and time periods evaluated, damages and adaptation costs were larger for RCP8.5 than RCP4.5. Estimated coastal erosion losses were also larger for RCP8.5. C1 [Melvin, April M.] US EPA, AAAS Sci & Technol Policy Fellow, Climate Change Div, Washington, DC 20460 USA. [Boehlert, Brent; Neumann, James E.; Baumann, Matthew S.; Rennels, Lisa; Bothner, Alexandra] Ind Econ Inc, Cambridge, MA 02140 USA. [Boehlert, Brent] MIT, Joint Program Sci & Policy Global Change, Cambridge, MA 02139 USA. [Chinowsky, Paul; Espinet, Xavier] Resilient Analyt, Boulder, CO 80309 USA. [Martinich, Jeremy] US EPA, Climate Change Div, Washington, DC 20460 USA. [Nicolsky, Dmitry J.; Marchenko, Sergey S.] Univ Alaska, Geophys Inst, Fairbanks, AK 99775 USA. RP Martinich, J (reprint author), US EPA, Climate Change Div, Washington, DC 20460 USA. EM martinich.jeremy@epa.gov FU US Environmental Protection Agency (EPA) Climate Change Division Contract [EP-D-14-031] FX We thank Lucy Page and Amy Schweikert for assistance in the development of this analysis and Ken Strzepek for helpful guidance. We also thank all who participated in the technical expert meeting held in Fairbanks, Alaska at the start of this project and provided additional guidance throughout the analysis. We thank John Walsh for providing comments on this manuscript. Two anonymous reviewers provided constructive feedback that greatly improved this manuscript. We acknowledge the financial support of US Environmental Protection Agency (EPA) Climate Change Division Contract EP-D-14-031. The views expressed here are those of the authors and do not necessarily reflect those of the EPA. NR 62 TC 0 Z9 0 U1 15 U2 15 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD JAN 10 PY 2017 VL 114 IS 2 BP E122 EP E131 DI 10.1073/pnas.1611056113 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EH0FR UT WOS:000391439300004 PM 28028223 ER PT J AU Londono, NA Suarez, DG Velasquez, HI Ruiz-Mercado, GJ AF Cano Londono, Natalia A. Gallego Suarez, Dario Velasquez, Hector I. Ruiz-Mercado, Gerardo J. TI Emergy analysis for the sustainable utilization of biosolids generated in a municipal wastewater treatment plant SO JOURNAL OF CLEANER PRODUCTION LA English DT Article DE Emergy; Sustainability; Indicator; Biosolid; Gasification; Fertilizer ID SEWAGE-SLUDGE; FLUIDIZED-BED; INDICATORS; SYSTEMS; GASIFICATION; ELECTRICITY; REGION AB This contribution describes the application of an emergy-based methodology for comparing two management alternatives of biosolids produced in a wastewater treatment plant. The current management practice of using biosolids as soil fertilizers was evaluated and compared to another alternative, the recovery of energy from the biosolid gasification process. This emergy assessment and comparison approach identifies more sustainable processes which achieve economic and social benefits with a minimal environmental impact. In addition, emergy-based sustainability indicators and the GREEN SCOPE methodology were used to compare the two biosolid management alternatives. According to the sustainability assessment results, the energy production from biosolid gasification is energetically profitable, economically viable, and environmentally suitable. Furthermore, it was found that the current use of biosolids as soil fertilizer does not generate any considerable environmental stress, has the potential to achieve more economic benefits, and a post-processing of biosolids prior to its use as soil fertilizer improves its sustainability performance. In conclusion, this emergy analysis provides a sustainability assessment of both alternatives of biosolid management and helps decision-makers to identify opportunities for improvement during the current process of biosolid management. Published by Elsevier Ltd. C1 [Cano Londono, Natalia A.; Gallego Suarez, Dario; Velasquez, Hector I.] Univ Nacl Colombia Sede Medellin, Medellin 050041, Colombia. [Ruiz-Mercado, Gerardo J.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Ruiz-Mercado, GJ (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. EM nacanol@unal.edu.co; dgallego@unal.edu.co; hivelasq@unal.edu.co; Ruiz-Mercado.Gerardo@epa.gov FU School of Mines at the National University of Colombia - Medellin Campus; Bioprocess and Reactive Flow Research Group FX The authors thank the San Fernando Wastewater Treatment Plant and the Empresas Publicas de Medellin (EPM) for the provided data and recommendations. Andres Naranjo who provided valuable support for the thermodynamic calculations. This research was supported by the 1) School of Mines at the National University of Colombia - Medellin Campus; 2) Bioprocess and Reactive Flow Research Group. NR 57 TC 0 Z9 0 U1 29 U2 29 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0959-6526 EI 1879-1786 J9 J CLEAN PROD JI J. Clean Prod. PD JAN 10 PY 2017 VL 141 BP 182 EP 193 DI 10.1016/j.jclepro.2016.09.033 PG 12 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental; Environmental Sciences SC Science & Technology - Other Topics; Engineering; Environmental Sciences & Ecology GA ED7ZC UT WOS:000389090300018 ER PT J AU Pye, HOT Murphy, BN Xu, L Ng, NL Carlton, AG Guo, HY Weber, R Vasilakos, P Appel, KW Budisulistiorini, SH Surratt, JD Nenes, A Hu, WW Jimenez, JL Isaacman-VanWertz, G Misztal, PK Goldstein, AH AF Pye, Havala O. T. Murphy, Benjamin N. Xu, Lu Ng, Nga L. Carlton, Annmarie G. Guo, Hongyu Weber, Rodney Vasilakos, Petros Appel, K. Wyat Budisulistiorini, Sri Hapsari Surratt, Jason D. Nenes, Athanasios Hu, Weiwei Jimenez, Jose L. Isaacman-VanWertz, Gabriel Misztal, Pawel K. Goldstein, Allen H. TI On the implications of aerosol liquid water and phase separation for organic aerosol mass SO ATMOSPHERIC CHEMISTRY AND PHYSICS LA English DT Article ID SOUTHEASTERN UNITED-STATES; CONDENSATION NUCLEUS ACTIVITY; ISOPRENE-EPOXYDIOLS; PARTICULATE MATTER; PARTICLE-PHASE; RELATIVE-HUMIDITY; CHEMICAL-COMPOSITION; INORGANIC AEROSOLS; REACTIVE UPTAKE; ANTHROPOGENIC EMISSIONS AB Organic compounds and liquid water are major aerosol constituents in the southeast United States (SE US). Water associated with inorganic constituents (inorganic water) can contribute to the partitioning medium for organic aerosol when relative humidities or organic matter to organic carbon (OM / OC) ratios are high such that separation relative humidities (SRH) are below the ambient relative humidity (RH). As OM / OC ratios in the SE US are often between 1.8 and 2.2, organic aerosol experiences both mixing with inorganic water and separation from it. Regional chemical transport model simulations including inorganic water (but excluding water uptake by organic compounds) in the partitioning medium for secondary organic aerosol (SOA) when RH > SRH led to increased SOA concentrations, particularly at night. Water uptake to the organic phase resulted in even greater SOA concentrations as a result of a positive feedback in which water uptake increased SOA, which further increased aerosol water and organic aerosol. Aerosol properties, such as the OM / OC and hygroscopicity parameter (kappa(org)), were captured well by the model compared with measurements during the Southern Oxidant and Aerosol Study (SOAS) 2013. Organic nitrates from monoterpene oxidation were predicted to be the least water-soluble semivolatile species in the model, but most biogenically derived semivolatile species in the Community Multiscale Air Quality (CMAQ) model were highly water soluble and expected to contribute to water-soluble organic carbon (WSOC). Organic aerosol and SOA precursors were abundant at night, but additional improvements in daytime organic aerosol are needed to close the model-measurement gap. When taking into account deviations from ideality, including both inorganic (when RH > SRH) and organic water in the organic partitioning medium reduced the mean bias in SOA for routine monitoring networks and improved model performance compared to observations from SOAS. Property updates from this work will be released in CMAQ v5.2. C1 [Pye, Havala O. T.; Murphy, Benjamin N.; Appel, K. Wyat] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC USA. [Xu, Lu; Ng, Nga L.; Vasilakos, Petros; Nenes, Athanasios] Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA. [Ng, Nga L.; Guo, Hongyu; Weber, Rodney; Nenes, Athanasios] Georgia Inst Technol, Sch Earth & Atmospher Sci, Atlanta, GA 30332 USA. [Carlton, Annmarie G.] Rutgers State Univ, Dept Environm Sci, New Brunswick, NJ USA. [Budisulistiorini, Sri Hapsari; Surratt, Jason D.] Univ North Carolina Chapel Hill, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. [Nenes, Athanasios] Natl Observ Athens, Inst Environm Res & Sustainable Dev, Palea Penteli 15236, Greece. [Nenes, Athanasios] Fdn Res & Technol Hellas, Inst Chem Engn Sci, Patras, Greece. [Hu, Weiwei; Jimenez, Jose L.] Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA. [Hu, Weiwei; Jimenez, Jose L.] Univ Colorado, Dept Chem & Biochem, Campus Box 215, Boulder, CO 80309 USA. [Isaacman-VanWertz, Gabriel; Misztal, Pawel K.; Goldstein, Allen H.] Univ Calif Berkeley, Dept Environm Sci Policy & Management, Berkeley, CA 94720 USA. [Goldstein, Allen H.] Univ Calif Berkeley, Dept Civil & Environm Engn, Berkeley, CA 94720 USA. [Carlton, Annmarie G.] Univ Calif Irvine, Dept Chem, Irvine, CA 92717 USA. RP Pye, HOT (reprint author), US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC USA. EM pye.havala@epa.gov RI Jimenez, Jose/A-5294-2008; Pye, Havala/F-5392-2012; OI Jimenez, Jose/0000-0001-6203-1847; Pye, Havala/0000-0002-2014-2140; Misztal, Pawel K/0000-0003-1060-1750; Carlton, Annmarie/0000-0002-8574-1507 FU US EPA through its Office of Research and Development; NSF [1455588, 1242258, AGS-1360834, CHE-1404644, AGS-1250569, DGE 1106400]; EPA [RD-83540301, R835404]; EPRI [10004734]; EPA STAR [83587701-0, R83512, R835407]; NSF-AGS [1242155] FX We thank the Computer Sciences Corporation for emission processing and Shaojie Song for GEOS-Chem simulations. We thank Jesse Bash, Donna Schwede, and Matt Woody for useful discussion and Kirk Baker for developing the SOAS modeling platform. We thank William H. Brune, David O. Miller, Philip A. Feiner, and Li Zhang for providing OH data. We thank Paul Wennberg and Tran Nguyen for providing CTR CIMS data for IEPOX + ISOPOOH. We thank Rohit Mathur and Golam Sarwar for providing comments on the paper. The US EPA through its Office of Research and Development supported the research described here. It has been subjected to Agency administrative review and approved for publication but may not necessarily reflect official Agency policy. The Ng group was supported by NSF grant 1455588 and EPA grant RD-83540301. Rodney Weber was supported by NSF grant 1242258. Weiwei Hu and Jose L. Jimenez were supported by EPRI 10004734, NSF AGS-1360834, and EPA STAR 83587701-0. Annmarie G. Carlton was supported by EPA STAR grant R83512 and NSF-AGS 1242155. The Surratt group was supported by EPRI as well from EPA grant R835404 and NSF Grant CHE-1404644. The Goldstein team at UC Berkeley acknowledge support from EPA STAR Grant R835407 and NSF Grant AGS-1250569. Gabriel Isaacman-VanWertz is supported by the NSF Graduate Research Fellowship (no. DGE 1106400). NR 121 TC 1 Z9 1 U1 4 U2 4 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1680-7316 EI 1680-7324 J9 ATMOS CHEM PHYS JI Atmos. Chem. Phys. PD JAN 6 PY 2017 VL 17 IS 1 BP 343 EP 369 DI 10.5194/acp-17-343-2017 PG 27 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA EK1IN UT WOS:000393679100002 ER PT J AU Lee, S Barron, MG AF Lee, Sehan Barron, Mace G. TI Structure-Based Understanding of Binding Affinity and Mode of Estrogen Receptor alpha Agonists and Antagonists SO PLOS ONE LA English DT Article ID ENDOCRINE-DISRUPTING CHEMICALS; LIGAND-BINDING; DOMAIN; IDENTIFICATION; PREDICTION; INSIGHTS; WILDLIFE; DOCKING; HUMANS; QSAR AB The flexible hydrophobic ligand binding pocket (LBP) of estrogen receptor alpha (ER alpha) allows the binding of a wide variety of endocrine disruptors. Upon ligand binding, the LBP reshapes around the contours of the ligand and stabilizes the complex by complementary hydrophobic interactions and specific hydrogen bonds with the ligand. Here we present a framework for quantitative analysis of the steric and electronic features of the human ER alpha-ligand complex using three dimensional (3D) protein-ligand interaction description combined with 3D-QSAR approach. An empirical hydrophobicity density field is applied to account for hydrophobic contacts of ligand within the LBP. The obtained 3D-QSAR model revealed that hydrophobic contacts primarily determine binding affinity and govern binding mode with hydrogen bonds. Several residues of the LBP appear to be quite flexible and adopt a spectrum of conformations in various ER alpha-ligand complexes, in particular His524. The 3D-QSAR was combined with molecular docking based on three receptor conformations to accommodate receptor flexibility. The model indicates that the dynamic character of the LBP allows accommodation and stable binding of structurally diverse ligands, and proper representation of the protein flexibility is critical for reasonable description of binding of the ligands. Our results provide a quantitative and mechanistic understanding of binding affinity and mode of ER alpha agonists and antagonists that may be applicable to other nuclear receptors. C1 [Lee, Sehan; Barron, Mace G.] US EPA, Gulf Ecol Div, Gulf Breeze, FL 32561 USA. RP Lee, S (reprint author), US EPA, Gulf Ecol Div, Gulf Breeze, FL 32561 USA. EM lee.sehan@epa.gov FU U.S. EPA; U.S. Department of Energy FX This research was supported in part by an appointment to the Oak Ridge Institute for Science and Education participant research program supported by an interagency agreement between the U.S. EPA and the U.S. Department of Energy.; This research was supported in part by an appointment to the ORISE participant research program supported by an interagency agreement between the U.S. EPA and the U.S. Department of Energy. We thank Jeremy Leonard and Kamel Mansouri for review of a draft of this manuscript. The conclusions may not necessarily reflect the views of EPA and no official endorsement should be inferred. NR 41 TC 0 Z9 0 U1 5 U2 5 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JAN 6 PY 2017 VL 12 IS 1 AR e0169607 DI 10.1371/journal.pone.0169607 PG 14 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EH3AX UT WOS:000391641500114 PM 28061508 ER PT J AU Baxter, LK Crooks, JL Sacks, JD AF Baxter, Lisa K. Crooks, James L. Sacks, Jason D. TI Influence of exposure differences on city-to-city heterogeneity in PM2.5-mortality associations in US cities SO ENVIRONMENTAL HEALTH LA English DT Article DE Particulate matter; Epidemiology; Exposure; Meta-regression; Cluster analysis ID FINE PARTICULATE MATTER; AIR EXCHANGE-RATE; RESIDENTIAL INFILTRATION; PERSONAL PARTICULATE; POLLUTION; MORTALITY; PARTICLES; PM2.5; INDOOR AB Background: Multi-city population-based epidemiological studies have observed heterogeneity between city-specific fine particulate matter (PM2.5)-mortality effect estimates. These studies typically use ambient monitoring data as a surrogate for exposure leading to potential exposure misclassification. The level of exposure misclassification can differ by city affecting the observed health effect estimate. Methods: The objective of this analysis is to evaluate whether previously developed residential infiltration-based city clusters can explain city-to-city heterogeneity in PM2.5 mortality risk estimates. In a prior paper 94 cities were clustered based on residential infiltration factors (e.g. home age/size, prevalence of air conditioning (AC)), resulting in 5 clusters. For this analysis, the association between PM2.5 and all-cause mortality was first determined in 77 cities across the United States for 2001-2005. Next, a second stage analysis was conducted evaluating the influence of cluster assignment on heterogeneity in the risk estimates. Results: Associations between a 2-day (lag 0-1 days) moving average of PM2.5 concentrations and non-accidental mortality were determined for each city. Estimated effects ranged from -3.2 to 5.1% with a pooled estimate of 0.33% (95% CI: 0.13, 0.53) increase in mortality per 10 mu g/m(3) increase in PM2.5. The second stage analysis determined that cluster assignment was marginally significant in explaining the city-to-city heterogeneity. The health effects estimates in cities with older, smaller homes with less AC (Cluster 1) and cities with newer, smaller homes with a large prevalence of AC (Cluster 3) were significantly lower than the cluster consisting of cities with older, larger homes with a small percentage of AC. Conclusions: This is the first study that attempted to examine whether multiple exposure factors could explain the heterogeneity in PM2.5-mortality associations. The results of this study were found to explain a small portion (6%) of this heterogeneity. C1 [Baxter, Lisa K.; Crooks, James L.] US EPA, Natl Hlth & Environm Effects Res Lab, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. [Sacks, Jason D.] US EPA, Natl Ctr Environm Assessment, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. [Crooks, James L.] Natl Jewish Hlth, Div Biostat & Bioinformat, 1400 Jackson St, Denver, CO 80206 USA. [Crooks, James L.] Natl Jewish Hlth, Dept Biomed Res, 1400 Jackson St, Denver, CO 80206 USA. [Crooks, James L.] Colorado Sch Publ Hlth, Dept Epidemiol, 13001 E 7th Pl, Aurora, CO 80045 USA. RP Baxter, LK (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM Baxter.lisa@epa.gov NR 26 TC 0 Z9 0 U1 6 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1476-069X J9 ENVIRON HEALTH-GLOB JI Environ. Health PD JAN 4 PY 2017 VL 16 AR 1 DI 10.1186/s12940-016-0208-y PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA EH4PF UT WOS:000391752400001 PM 28049482 ER PT J AU Xu, ZL Langie, SAS De Boever, P Taylor, JA Niu, L AF Xu, Zongli Langie, Sabine A. S. De Boever, Patrick Taylor, Jack A. Niu, Liang TI RELIC: a novel dye-bias correction method for Illumina Methylation BeadChip SO BMC GENOMICS LA English DT Article DE RELIC; DNA methylation; Dye-bias correction; Illumina HumanMethylation450; Illumina MethylationEPIC; Data preprocessing ID PROBE DESIGN BIAS; NORMALIZATION; ARRAY; QUANTILE AB Background: The Illumina Infinium HumanMethylation450 BeadChip and its successor, Infinium MethylationEPIC BeadChip, have been extensively utilized in epigenome-wide association studies. Both arrays use two fluorescent dyes (Cy3-green/Cy5-red) to measure methylation level at CpG sites. However, performance difference between dyes can result in biased estimates of methylation levels. Results: Here we describe a novel method, called REgression on Logarithm of Internal Control probes (RELIC) to correct for dye bias on whole array by utilizing the intensity values of paired internal control probes that monitor the two color channels. We evaluate the method in several datasets against other widely used dye-bias correction methods. Results on data quality improvement showed that RELIC correction statistically significantly outperforms alternative dye-bias correction methods. We incorporated the method into the R package ENmix, which is freely available from the Bioconductor website(https://www.bioconductor.org/packages/release/bioc/html/ENmix.html). Conclusions: RELIC is an efficient and robust method to correct for dye-bias in Illumina Methylation BeadChip data. It outperforms other alternative methods and conveniently implemented in R package ENmix to facilitate DNA methylation studies. C1 [Xu, Zongli; Taylor, Jack A.] Natl Inst Environm Hlth Sci, Epidemiol Branch, NIH, Res Triangle Pk, NC USA. [Langie, Sabine A. S.; De Boever, Patrick] Flemish Inst Technol Res VITO, Environm Risk & Hlth Unit, Mol, Belgium. [Langie, Sabine A. S.; De Boever, Patrick] Hasselt Univ, Fac Sci, Diepenbeek, Belgium. [Taylor, Jack A.] Natl Inst Environm Hlth Sci, Epigenet & Stem Cell Biol Lab, NIH, Res Triangle Pk, NC USA. [Niu, Liang] Univ Cincinnati, Coll Med, Dept Environm Hlth, Div Biostat & Bioinformat, Cincinnati, OH 45267 USA. RP Niu, L (reprint author), Univ Cincinnati, Coll Med, Dept Environm Hlth, Div Biostat & Bioinformat, Cincinnati, OH 45267 USA. EM niulg@ucmail.uc.edu OI xu, zongli/0000-0002-9034-8902; taylor, jack/0000-0001-5303-6398 FU Center for Environmental Genetics grant (National Institute of Environmental Health Sciences) [P30-ES00606]; Intramural Research Program of the NIH, National Institute of Environmental Health Sciences [Z01 ES049033, Z01 ES049032]; VITO-FWO post-doctoral fellowship [12L5216N] FX This work was supported by the Center for Environmental Genetics grant (National Institute of Environmental Health Sciences award P30-ES00606), Intramural Research Program of the NIH, National Institute of Environmental Health Sciences (Z01 ES049033, and Z01 ES049032), and VITO-FWO post-doctoral fellowship (12L5216N). NR 14 TC 0 Z9 0 U1 5 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PD JAN 3 PY 2017 VL 18 AR 4 DI 10.1186/s12864-016-3426-3 PG 7 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA EG8UG UT WOS:000391332000004 PM 28049437 ER PT J AU Giordano, MR Kalnajs, LE Avery, A Goetz, JD Davis, SM DeCarlo, PF AF Giordano, Michael R. Kalnajs, Lars E. Avery, Anita Goetz, J. Douglas Davis, Sean M. DeCarlo, Peter F. TI A missing source of aerosols in Antarctica - beyond long-range transport, phytoplankton, and photochemistry SO ATMOSPHERIC CHEMISTRY AND PHYSICS LA English DT Article ID SEA-SALT-SULFATE; CLOUD CONDENSATION NUCLEI; POSITIVE MATRIX FACTORIZATION; ROSS ISLAND REGION; BOUNDARY-LAYER; MASS-SPECTROMETER; ATMOSPHERIC AEROSOL; COASTAL ANTARCTICA; SIZE DISTRIBUTION; SULFUR EMISSIONS AB Understanding the sources and evolution of aerosols is crucial for constraining the impacts that aerosols have on a global scale. An unanswered question in atmospheric science is the source and evolution of the Antarctic aerosol population. Previous work over the continent has primarily utilized low temporal resolution aerosol filters to answer questions about the chemical composition of Antarctic aerosols. Bulk aerosol sampling has been useful in identifying seasonal cycles in the aerosol populations, especially in populations that have been attributed to Southern Ocean phytoplankton emissions. However, real-time, high-resolution chemical composition data are necessary to identify the mechanisms and exact timing of changes in the Antarctic aerosol. The recent 2ODIAC (2-Season Ozone Depletion and Interaction with Aerosols Campaign) field campaign saw the first ever deployment of a real-time, high-resolution aerosol mass spectrometer (SP-AMS - soot particle aerosol mass spectrometer -or AMS) to the continent. Data obtained from the AMS, and a suite of other aerosol, gas-phase, and meteorological instruments, are presented here. In particular, this paper focuses on the aerosol population over coastal Antarctica and the evolution of that population in austral spring. Results indicate that there exists a sulfate mode in Antarctica that is externally mixed with a mass mode vacuum aerodynamic diameter of 250 nm. Springtime increases in sulfate aerosol are observed and attributed to biogenic sources, in agreement with previous research identifying phytoplankton activity as the source of the aerosol. Furthermore, the total Antarctic aerosol population is shown to undergo three distinct phases during the winter to summer transition. The first phase is dominated by highly aged sulfate particles comprising the majority of the aerosol mass at low wind speed. The second phase, previously unidentified, is the generation of a sub-250 nm aerosol population of unknown composition. The second phase appears as a transitional phase during the extended polar sunrise. The third phase is marked by an increased importance of biogenically derived sulfate to the total aerosol population (photolysis of dimethyl sulfate and methanesulfonic acid (DMS and MSA)). The increased importance of MSA is identified both through the direct, real-time measurement of aerosol MSA and through the use of positive matrix factorization on the sulfur-containing ions in the high-resolution mass-spectral data. Given the importance of sub-250 nm particles, the aforementioned second phase suggests that early austral spring is the season where new particle formation mechanisms are likely to have the largest contribution to the aerosol population in Antarctica. C1 [Giordano, Michael R.; Avery, Anita; Goetz, J. Douglas; DeCarlo, Peter F.] Drexel Univ, Dept Civil Architectural & Environm Engn, Philadelphia, PA 19104 USA. [Kalnajs, Lars E.] Univ Colorado, Atmospher & Space Phys Lab, Campus Box 392, Boulder, CO 80309 USA. [Davis, Sean M.] NOAA, Div Chem Sci, Earth Syst Res Lab, Boulder, CO USA. [Davis, Sean M.] Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA. [DeCarlo, Peter F.] Drexel Univ, Dept Chem, Philadelphia, PA 19104 USA. [Giordano, Michael R.] US EPA, Hosted, Washington, DC 20460 USA. RP DeCarlo, PF (reprint author), Drexel Univ, Dept Civil Architectural & Environm Engn, Philadelphia, PA 19104 USA.; DeCarlo, PF (reprint author), Drexel Univ, Dept Chem, Philadelphia, PA 19104 USA. EM pfd33@drexel.edu RI DeCarlo, Peter/B-2118-2008; Manager, CSD Publications/B-2789-2015 OI DeCarlo, Peter/0000-0001-6385-7149; FU National Science Foundation [1341628, 1341492] FX The authors of this paper would like to thank the National Science Foundation for funding this work through grant numbers 1341628 and 1341492. Additionally, the authors extend many thanks to all of the support staff at McMurdo Station, especially Tony Buchanan; without their support none of this work would have been possible. The authors would also like to thank Terry Deshler, Andrew Slater, and Anondo Mukherjee for their direct help with measurements in the field and Erin Frolli for her assistance in satellite image retrieval and creation. The authors would also like to thank and acknowledge Soeren Zorn and Julia Schmale for their permission to reproduce their data in Fig. 5. Any opinions, findings, and conclusions expressed in this material are those of the authors and do not necessarily reflect the views of the NSF. NR 79 TC 0 Z9 0 U1 10 U2 10 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1680-7316 EI 1680-7324 J9 ATMOS CHEM PHYS JI Atmos. Chem. Phys. PD JAN 2 PY 2017 VL 17 IS 1 BP 1 EP 20 DI 10.5194/acp-17-1-2017 PG 20 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA EH9OO UT WOS:000392100900001 ER PT J AU Palmer, J Knudsen, T Egnash, L Kothiya, P Houck, K Donley, E AF Palmer, J. Knudsen, T. Egnash, L. Kothiya, P. Houck, K. Donley, E. TI Human Pluripotent Stem Cell-Based Assay Predicts Developmental Toxicity Potential of ToxCast Chemicals SO INTERNATIONAL JOURNAL OF TOXICOLOGY LA English DT Meeting Abstract CT 37th Annual Meeting of the American-College-of-Toxicology (ACT) CY NOV 06-09, 2016 CL Baltimore, MD SP Amer Coll Toxicol C1 [Palmer, J.; Egnash, L.; Donley, E.] Stemina Biomarker Discovery Inc, Madison, WI USA. [Knudsen, T.; Kothiya, P.; Houck, K.] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1091-5818 EI 1092-874X J9 INT J TOXICOL JI Int. J. Toxicol. PD JAN-FEB PY 2017 VL 36 IS 1 MA P413 BP 76 EP 77 PG 2 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA EP2PJ UT WOS:000397225300075 ER PT J AU Zhang, ZH Myers, JMB Brandt, EB Ryan, PH Lindsey, M Mintz-Cole, RA Reponen, T Vesper, SJ Forde, F Ruff, B Bass, SA LeMasters, GK Bernstein, DI Lockey, J Budelsky, AL Hershey, GKK AF Zhang, Zhonghua Myers, Jocelyn M. Biagini Brandt, Eric B. Ryan, Patrick H. Lindsey, Mark Mintz-Cole, Rachael A. Reponen, Tiina Vesper, Stephen J. Forde, Frank Ruff, Brandy Bass, Stacey A. LeMasters, Grace K. Bernstein, David I. Lockey, James Budelsky, Alison L. Hershey, Gurjit K. Khurana TI beta-Glucan exacerbates allergic asthma independent of fungal sensitization and promotes steroid-resistant T(H)2/T(H)17 responses SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Article DE Childhood asthma; beta-glucan; fungi; house dust mite; IL-17A; fungal exposure; allergy ID RELATIVE MOLDINESS INDEX; CHILDHOOD ASTHMA; CLADOSPORIUM-CLADOSPORIOIDES; AIRWAY HYPERRESPONSIVENESS; EXPOSURE; DECTIN-1; IL-17; CELLS; RECOGNITION; PREDICTOR AB Background: Allergic sensitization to fungi has been associated with asthma severity. As a result, it has been largely assumed that the contribution of fungi to allergic disease is mediated through their potent antigenicity. Objective: We sought to determine the mechanism by which fungi affect asthma development and severity. Methods: We integrated epidemiologic and experimental asthma models to explore the effect of fungal exposure on asthma development and severity. Results: We report that fungal exposure enhances allergen-driven T(H)2 responses, promoting severe allergic asthma. This effect is independent of fungal sensitization and can be reconstituted with beta-glucan and abrogated by neutralization of IL-17A. Furthermore, this severe asthma is resistant to steroids and characterized by mixed T(H)2 and T(H)17 responses, including IL-13(+)IL-17(+)CD4(+) double- producing effector T cells. Steroid resistance is dependent on fungus-induced TH17 responses because steroid sensitivity was restored in IL-17rc 2/2 mice. Similarly, in children with asthma, fungal exposure was associated with increased serum IL-17A levels and asthma severity. Conclusion: Our data demonstrate that fungi are potent immunomodulators and have powerful effects on asthma independent of their potential to act as antigens. Furthermore, our results provide a strong rationale for combination treatment strategies targeting IL-17A for this subgroup of fungus-exposed patients with difficult-to-treat asthma. C1 [Zhang, Zhonghua; Myers, Jocelyn M. Biagini; Brandt, Eric B.; Lindsey, Mark; Mintz-Cole, Rachael A.; Forde, Frank; Ruff, Brandy; Bass, Stacey A.; LeMasters, Grace K.; Hershey, Gurjit K. Khurana] Cincinnati Childrens Hosp Med Ctr, Div Asthma Res, Cincinnati, OH 45229 USA. [Ryan, Patrick H.] Cincinnati Childrens Hosp Med Ctr, Div Biostat & Epidemiol, Cincinnati, OH 45229 USA. [Zhang, Zhonghua; Myers, Jocelyn M. Biagini; Brandt, Eric B.; Ryan, Patrick H.; Lindsey, Mark; Mintz-Cole, Rachael A.; Forde, Frank; Ruff, Brandy; Bass, Stacey A.; LeMasters, Grace K.; Hershey, Gurjit K. Khurana] Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH USA. [Reponen, Tiina; LeMasters, Grace K.; Lockey, James] Univ Cincinnati, Coll Med, Dept Environm Hlth, Cincinnati, OH 45267 USA. [Bernstein, David I.] Univ Cincinnati, Coll Med, Dept Internal Med, Cincinnati, OH USA. [Vesper, Stephen J.] US EPA, Cincinnati, OH 45268 USA. [Budelsky, Alison L.] Amgen Inc, Dept Inflammat Res, Seattle, WA USA. RP Hershey, GKK (reprint author), Cincinnati Childrens Hosp Med Ctr, Div Asthma Res & Allergy Immunol, 3333 Burnet Ave,MLC 7037, Cincinnati, OH 45229 USA. EM Gurjit.Hershey@cchmc.org FU National Institutes of Health grant [2U19AI70235, R01ES011170, R01ES019890]; National Institute of Environmental Health Sciences grant [T32 ES010957] FX Supported by National Institutes of Health grants 2U19AI70235 (to G.K.K.H. and J.M.B.M.), R01ES011170 (to G.K.L.), R01ES019890 (to P.H.R.), and National Institute of Environmental Health Sciences grant T32 ES010957 (to Z.Z.). NR 53 TC 0 Z9 0 U1 1 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0091-6749 EI 1097-6825 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD JAN PY 2017 VL 139 IS 1 BP 54 EP + DI 10.1016/j.jaci.2016.02.031 PG 20 WC Allergy; Immunology SC Allergy; Immunology GA EK5WM UT WOS:000393996800007 PM 27221135 ER PT J AU Miller, CN Rayalam, S AF Miller, Colette N. Rayalam, Srujana TI The role of micronutrients in the response to ambient air pollutants: Potential mechanisms and suggestions for research design SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS LA English DT Review ID VITAMIN-A-DEFICIENCY; SICKLE-CELL-DISEASE; ENVIRONMENTAL TOBACCO-SMOKE; AIRBORNE PARTICULATE MATTER; INCOME PRESCHOOL-CHILDREN; NEURAL-TUBE DEFECTS; IRON-DEFICIENCY; FOLATE-DEFICIENCY; LUNG-CANCER; CARDIOVASCULAR-DISEASE AB People living in regions of low socioeconomic status are thought to be prone to higher exposures to environmental pollutants, poor nutrition, and numerous preventable diseases and infections. Poverty correlates with pollution and malnutrition; however, limited studies examined their interrelationship. The well-studied, deleterious health effects attributed to environmental pollutants and poor nutrition may act in combination with produce more severe adverse health outcomes than any one factor alone. Deficiencies in specific nutrients render the body more susceptible to injury which may influence the pathways that serve as the mechanistic responses to ambient air pollutants. This review (1) explores specific micronutrients that are of global concern, (2) explains how these nutrients may impact the body's response to ambient air pollution, and (3) provides guidance on designing animal models of nutritional deficiency. It is likely that those individuals who reside in regions of high ambient air pollution are similarly malnourished. Therefore, it is important that research identifies specific nutrients of concern and their impact in identified regions of high ambient air pollution. C1 [Miller, Colette N.] US EPA, Natl Hlth & Environm Effects Res Lab, Environm Publ Hlth Div, Res Triangle Pk, NC 27711 USA. [Rayalam, Srujana] Philadelphia Coll Osteopath Med, Dept Pharmaceut Sci, Suwanee, GA USA. RP Miller, CN (reprint author), US EPA, Natl Hlth & Environm Effects Lab, Environm Publ Hlth Div, Cardiovasc & Immunol Branch, 109 TW Alexander Dr,Mail Code B105-02, Res Triangle Pk, NC 27711 USA. EM miller.colette@epa.gov NR 140 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1093-7404 EI 1521-6950 J9 J TOXICOL ENV HEAL B JI J. Toxicol. Env. Health-Pt b-Crit. Rev. PY 2017 VL 20 IS 1 BP 38 EP 53 DI 10.1080/10937404.2016.1261746 PG 16 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA EO2XR UT WOS:000396559800003 PM 28145849 ER PT J AU Lu, JR Buse, H Struewing, I Zhao, A Lytle, D Ashbolt, N AF Lu, Jingrang Buse, Helen Struewing, Ian Zhao, Amy Lytle, Darren Ashbolt, Nicholas TI Annual variations and effects of temperature on Legionella spp. and other potential opportunistic pathogens in a bathroom SO ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH LA English DT Article DE Legionella; Opportunistic pathogen; Tapwater; Shower water; qPCR ID HOT-WATER-SYSTEMS; UNCHLORINATED DRINKING-WATER; COOLING-TOWER WATER; FREE-LIVING AMEBAS; PSEUDOMONAS-AERUGINOSA; LEGIONNAIRES-DISEASE; MYCOBACTERIUM-AVIUM; NONTUBERCULOUS MYCOBACTERIA; BACTERIAL COMMUNITIES; MOLECULAR-DETECTION AB Opportunistic pathogens (OPs) in drinking water, like Legionella spp., mycobacteria, Pseudomonas aeruginosa, and free-living amobae (FLA) are a risk to human health, due to their post-treatment growth in water systems. To assess and manage these risks, it is necessary to understand their variations and environmental conditions for the water routinely used. We sampled premise tap (N-cold = 26, N-hot = 26) and shower (N-shower = 26) waters in a bathroom and compared water temperatures to levels of OPs via qPCR and identified Legionella spp. by 16S ribosomal RNA (rRNA) gene sequencing. The overall occurrence and cell equivalent quantities (CE L-1) of Mycobacterium spp. were highest (100 %, 1.4 x 10(5)), followed by Vermamoeba vermiformis (91 %, 493), Legionella spp. (59 %, 146), P. aeruginosa (14 %, 10), and Acanthamoeba spp. (5 %, 6). There were significant variations of OP's occurrence and quantities, and water temperatures were associated with their variations, especially for Mycobacterium spp., Legionella spp., and V. vermiformis. The peaks observed for Legionella, mainly consisted of Legionella pneumophila sg1 or Legionella anisa, occurred in the temperature ranged from 19 to 49 degrees C, while Mycobacterium spp. and V. vermiformis not only co-occurred with Legionella spp. but also trended to increase with increasing temperatures. There were higher densities of Mycobacterium in first than second draw water samples, indicating their release from faucet/showerhead biofilm. Legionella spp. were mostly at detectable levels and mainly consisted of L. pneumophila, L. anisa, Legionella donaldsonii, Legionella tunisiensis, and an unknown drinking water isolate based on sequence analysis. Results from this study suggested potential health risks caused by opportunistic pathogens when exposed to warm shower water with low chlorine residue and the use of Mycobacterium spp. as an indicator of premise pipe biofilm and the control management of those potential pathogens. C1 [Lu, Jingrang; Zhao, Amy; Lytle, Darren] US EPA, Off Res & Dev, 26W Martin Luther King Dr, Cincinnati, OH 45268 USA. [Buse, Helen; Struewing, Ian] Pegasus Tech Serv Inc, Cincinnati, OH USA. [Ashbolt, Nicholas] Univ Alberta, Sch Publ Hlth, Edmonton, AB, Canada. RP Lu, JR (reprint author), US EPA, Off Res & Dev, 26W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM lu.jingrang@epa.gov FU U-SSW2.2B for pathogen detection; Research Effort of SSWR 6.01C for Distribution System Indicators and Plumbing Water FX This research was supported by U-SSW2.2B for pathogen detection and Research Effort of SSWR 6.01C for Distribution System Indicators and Plumbing Water. The views expressed in this article are those of the author(s) and do not necessarily represent the views or policies of the US Environmental Protection Agency. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 62 TC 0 Z9 0 U1 1 U2 1 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0944-1344 EI 1614-7499 J9 ENVIRON SCI POLLUT R JI Environ. Sci. Pollut. Res. PD JAN PY 2017 VL 24 IS 3 BP 2326 EP 2336 DI 10.1007/s11356-016-7921-5 PG 11 WC Environmental Sciences SC Environmental Sciences & Ecology GA EN6UL UT WOS:000396138800015 PM 27815848 ER PT J AU Juberg, DR Knudsen, TB Sander, M Beck, NB Faustman, EM Mendrick, DL Fowle, JR Hartung, T Tice, RR Lemazurier, E Becker, RA Fitzpatrick, SC Daston, GP Harrill, A Hines, RN Keller, DA Lipscomb, JC Watson, D Bahadori, T Crofton, KM AF Juberg, Daland R. Knudsen, Thomas B. Sander, Miriam Beck, Nancy B. Faustman, Elaine M. Mendrick, Donna L. Fowle, John R., III Hartung, Thomas Tice, Raymond R. Lemazurier, Emmanuel Becker, Richard A. Fitzpatrick, Suzanne Compton Daston, George P. Harrill, Alison Hines, Ronald N. Keller, Douglas A. Lipscomb, John C. Watson, David Bahadori, Tina Crofton, Kevin M. TI FutureTox III: Bridges for Translation SO TOXICOLOGICAL SCIENCES LA English DT Article DE predictive toxicology; in vitro and alternatives; regulatory/policy; risk assessment; testing alternatives ID ESTROGEN-RECEPTOR; RISK-ASSESSMENT; TOXICITY; 21ST-CENTURY; TOXICOLOGY; EXPOSURE; CHEMICALS; VISION; MODELS; PRIORITIZATION AB Future Tox III, a Society of Toxicology Contemporary Concepts in Toxicology workshop, was held in November 2015. Building upon Future Tox I and II, Future Tox III was focused on developing the high throughput risk assessment paradigm and taking the science of in vitro data and in silico models forward to explore the question-what progress is being made to address challenges in implementing the emerging big-data toolbox for risk assessment and regulatory decision-making. This article reports on the outcome of the workshop including 2 examples of where advancements in predictive toxicology approaches are being applied within Federal agencies, where opportunities remain within the exposome and AOP domains, and how collectively the toxicology community across multiple sectors can continue to bridge the translation from historical approaches to Tox21 implementation relative to risk assessment and regulatory decision-making. C1 [Juberg, Daland R.] Dow AgroSci, Indianapolis, IN 46268 USA. [Knudsen, Thomas B.; Hines, Ronald N.; Crofton, Kevin M.] US EPA, Res Triangle Pk, NC 27711 USA. [Sander, Miriam] Page One Editorial Serv, Boulder, CO USA. [Beck, Nancy B.; Becker, Richard A.] Amer Chem Council, Washington, DC USA. [Faustman, Elaine M.] Univ Washington, Seattle, WA 98195 USA. [Mendrick, Donna L.] US FDA, Silver Spring, MD USA. [Fowle, John R., III] Sci Inform LLC, Pittsboro, NC USA. [Hartung, Thomas] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Tice, Raymond R.] NIEHS, Natl Toxicol Program, Durham, NC USA. [Lemazurier, Emmanuel] INERIS Chron Risk Div, Verneeuil En Halatte, France. [Fitzpatrick, Suzanne Compton] US FDA, College Pk, MD USA. [Daston, George P.] Procter & Gamble Co, Cincinnati, OH USA. [Harrill, Alison] Univ Arkansas Med Sci, Little Rock, AR 72205 USA. [Keller, Douglas A.] Sanofi, Bridgewater, NJ USA. [Lipscomb, John C.] US EPA, Cincinnati, OH 45268 USA. [Watson, David] Lhasa Ltd, Leeds, W Yorkshire, England. [Bahadori, Tina] US EPA, Washington, DC 20460 USA. RP Juberg, DR (reprint author), Dow AgroSci, Indianapolis, IN 46268 USA. EM drjuberg@dow.com FU Society of Toxicology; Scientific Liaison Coalition; American Chemistry Council; Dow AgroSciences, LLC; Hamner Institutes for Health Sciences; Human Toxicology Project Consortium; Humane Society of the United States; National Institute of Environmental Health Sciences; U.S. Food and Drug Administration, Office of the Chief Scientist; National Center for Toxicological Reseach; Bayer Crop Science; NSF International; Syngenta Crop Protection LLC; TERA Center; University of Cincinnati; ToxServices; American Academy of Clinical Toxicology; American College of Toxicology; CAAT; Johns Hopkins Center for Alternatives to Animal Testing (CAAT); In Sphero; Lhasa Limited; Ramboll Environ; Safety Pharmacology Society; Society of Toxicologic Pathology; Teratology Society FX FutureTox III Sponsors included Society of Toxicology, Scientific Liaison Coalition, the American Chemistry Council, Dow AgroSciences, LLC, The Hamner Institutes for Health Sciences, Human Toxicology Project Consortium, The Humane Society of the United States, National Institute of Environmental Health Sciences, U.S. Food and Drug Administration, Office of the Chief Scientist and the National Center for Toxicological Reseach, Bayer Crop Science, NSF International, Syngenta Crop Protection LLC, TERA Center, University of Cincinnati, ToxServices, American Academy of Clinical Toxicology, American College of Toxicology, CAAT, Johns Hopkins Center for Alternatives to Animal Testing (CAAT), In Sphero, Lhasa Limited, Ramboll Environ, Safety Pharmacology Society, Society of Toxicologic Pathology, The Teratology Society. NR 41 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD JAN PY 2017 VL 155 IS 1 BP 22 EP 31 DI 10.1093/toxsci/kfw194 PG 10 WC Toxicology SC Toxicology GA EO9XL UT WOS:000397041300003 PM 27780885 ER PT J AU Hill, T Nelms, MD Edwards, SW Martin, M Judson, R Corton, JC Wood, CE AF Hill, Thomas, III Nelms, Mark D. Edwards, Stephen W. Martin, Matthew Judson, Richard Corton, J. Christopher Wood, Charles E. TI Negative Predictors of Carcinogenicity for Environmental Chemicals SO TOXICOLOGICAL SCIENCES LA English DT Article DE carcinogenicity; chemical; testing; predictive value; pathology ID RISK-ASSESSMENT; IN-VITRO; RODENT CARCINOGENICITY; SAFETY ASSESSMENT; CANCER-RISK; TOXICITY; MICE; CYTOTOXICITY; CONCORDANCE; TOXICOLOGY AB Recent international efforts have led to proposals for modified carcinogenicity testing paradigms based on data from shorter-term studies. The main goal of the current study was to evaluate the negative predictive value (NPV) of short-term toxicity indicators on carcinogenicity study outcomes and cancer classifications for chemicals previously reviewed by the U.S. Environmental Protection Agency (EPA). Pathology data were analyzed from over 900 acceptable 2-sex guideline subchronic (3-month) and carcinogenicity studies in the U.S. EPA Toxicity Reference Database. Chemical cancer classifications were obtained from annual reports of the U.S. EPA Office of Pesticide Programs. Histopathologic risk signals and evidence of hormonal perturbation in subchronic rat studies provided 56% NPV for any tumor outcome in the rat or mouse and 75% NPV for cancer classifications not requiring quantitative risk assessment (qRA). In comparison, lack of activity in a battery of 35 in vitro cytotoxicity assays from the U.S. EPA ToxCast library provided 49% NPV for any tumor outcome and 80% NPV for cancer classifications not requiring qRA. These findings support the idea that the absence of short-term bioactivity may provide useful information for prioritizing chemicals based on potential carcinogenic risk. Additional data streams are needed to further refine these models. C1 [Hill, Thomas, III; Nelms, Mark D.] US EPA, Oak Ridge Inst Sci & Educ Participant, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Corton, J. Christopher; Wood, Charles E.] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Martin, Matthew; Judson, Richard] US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27711 USA. RP Wood, CE (reprint author), US EPA, MD-B105-03,109 TW Alexander Dr, Res Triangle Pk, NC 27709 USA. EM wood.charles@epa.gov FU U.S. EPA Office of Research and Development FX U.S. EPA Office of Research and Development. NR 48 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD JAN PY 2017 VL 155 IS 1 BP 157 EP 169 DI 10.1093/toxsci/kfw195 PG 13 WC Toxicology SC Toxicology GA EO9XL UT WOS:000397041300014 PM 27679563 ER PT J AU Marchitti, SA Mazur, CS Dillingham, CM Rawat, S Sharma, A Zastre, J Kenneke, JF AF Marchitti, Satori A. Mazur, Christopher S. Dillingham, Caleb M. Rawat, Swati Sharma, Anshika Zastre, Jason Kenneke, John F. TI Inhibition of the Human ABC Efflux Transporters P-gp and BCRP by the BDE-47 Hydroxylated Metabolite 6-OH-BDE-47: Considerations for Human Exposure SO TOXICOLOGICAL SCIENCES LA English DT Article DE ABC transporters; BCRP; brominated flame retardants; MDR1; P-gp; polybrominated diphenyl ethers (PBDEs) ID POLYBROMINATED DIPHENYL ETHERS; BROMINATED FLAME RETARDANTS; IN-VITRO; POLYCHLORINATED-BIPHENYLS; BREAST-MILK; CORD-BLOOD; OH-PBDES; GLYCOPROTEIN; CELLS; PESTICIDES AB High body burdens of polybrominated diphenyl ethers (PBDEs) in infants and young children have led to increased concern over their potential impact on human development. PBDE exposure can alter the expression of genes involved in thyroid homeostasis, including those of ATP-binding cassette (ABC) transporters, which mediate cellular xenobiotic efflux. However, little information exists on how PBDEs interact with ABC transporters such as P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP). The purpose of this study was to evaluate the interactions of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) and its hydroxylated metabolite 6-OH-BDE-47 with P-gp and BCRP, using human MDR1-and BCRP-expressing membrane vesicles and stably transfected NIH-3T3-MDR1 and MDCK-BCRP cells. In P-gp membranes, BDE-47 did not affect P-gp activity; however, 6-OH-BDE-47 inhibited P-gp activity at low mu M concentrations (IC50 +/- 11.7 mu M). In BCRP membranes, BDE-47 inhibited BCRP activity; however, 6-OH-BDE-47 was a stronger inhibitor [IC50 +/- 45.9 mu M (BDE-47) vs. IC50 +/- 9.4 mu M (6-OH-BDE-47)]. Intracellular concentrations of known P-gp and BCRP substrates [(H-3)-paclitaxel and (H-3)-prazosin, respectively] were significantly higher (indicating less efflux) in NIH-3T3-MDR1 and MDCK-BCRP cells in the presence of 6-OH-BDE-47, but not BDE-47. Collectively, our results indicate that the BDE-47 metabolite 6-OH-BDE-47 is an inhibitor of both P-gp and BCRP efflux activity. These findings suggest that some effects previously attributed to BDE-47 in biological systems may actually be due to 6-OH-BDE-47. Considerations for human exposure are discussed. C1 [Marchitti, Satori A.; Mazur, Christopher S.; Dillingham, Caleb M.; Rawat, Swati; Kenneke, John F.] US EPA, Natl Exposure Res Lab, Athens, GA 30605 USA. [Sharma, Anshika; Zastre, Jason] Univ Georgia, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA. RP Kenneke, JF (reprint author), US EPA, 960 Coll Stn Rd, Athens, GA 30605 USA. EM kenneke.john@epa.gov FU U.S. Environmental Protection Agency; U.S. Department of Energy [DW8992298301]; U.S. Environmental Protection Agency [DW8992298301] FX This work was supported by funding from the U.S. Environmental Protection Agency and by an appointment to the Postdoctoral Research Program at the Computational Exposure Division, administered by the Oak Ridge Institute for Science and Education through Interagency Agreement No. [DW8992298301] between the U.S. Department of Energy and the U.S. Environmental Protection Agency. NR 62 TC 0 Z9 0 U1 1 U2 1 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD JAN PY 2017 VL 155 IS 1 BP 270 EP 282 DI 10.1093/toxsci/kfw209 PG 13 WC Toxicology SC Toxicology GA EO9XL UT WOS:000397041300023 PM 28031414 ER PT J AU Aschner, M Ceccatelli, S Daneshian, M Fritsche, E Hasiwa, N Hartung, T Hogberg, HT Leist, M Li, A Mundy, WR Padilla, S Piersma, AH Bal-Price, A Seiler, A Westerink, RH Zimmer, B Lein, PJ AF Aschner, Michael Ceccatelli, Sandra Daneshian, Mardas Fritsche, Ellen Hasiwa, Nina Hartung, Thomas Hogberg, Helena T. Leist, Marcel Li, Abby Mundy, William R. Padilla, Stephanie Piersma, Aldert H. Bal-Price, Anna Seiler, Andrea Westerink, Remco H. Zimmer, Bastian Lein, Pamela J. TI Reference Compounds for Alternative Test Methods to Indicate Developmental Neurotoxicity (DNT) Potential of Chemicals: Example Lists and Criteria for their Selection and Use SO ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION LA English DT Editorial Material DE neurotoxicity; specificity; test development; AOP; validation ID ADVERSE OUTCOME PATHWAYS; NEURAL PROGENITOR CELLS; HISTONE DEACETYLASE INHIBITORS; STAKEHOLDER NETWORK ISTNET; NEONATAL BRAIN-DEVELOPMENT; POSTNATAL MOUSE-BRAIN; EMBRYONIC STEM-CELLS; TRANS-RETINOIC ACID; PRENATAL EXPOSURE; IN-VITRO AB There is a paucity of information concerning the developmental neurotoxicity (DNT) hazard posed by industrial and environmental chemicals. New testing approaches will most likely be based on batteries of alternative and complementary (non-animal) tests. As DNT is assumed to result from the modulation of fundamental neurodevelopmental processes (such as neuronal differentiation, precursor cell migration or neuronal network formation) by chemicals, the first generation of alternative DNT tests target these processes. The advantage of such types of assays is that they capture toxicants with multiple targets and modes-of-action. Moreover, the processes modelled by the assays can be linked to toxicity endophenotypes, i.e., alterations in neural connectivity that form the basis for neurofunctional deficits in man. The authors of this review convened in a workshop to define criteria for the selection of positive/negative controls, to prepare recommendations on their use, and to initiate the setup of a directory of reference chemicals. For initial technical optimization of tests, a set of > 50 endpoint-specific control compounds was identified. For further test development, an additional "test" set of 33 chemicals considered to act directly as bona fide DNT toxicants is proposed, and each chemical is annotated to the extent it fulfills these criteria. A tabular compilation of the original literature used to select the test set chemicals provides information on statistical procedures, and toxic/non-toxic doses (both for pups and dams). Suggestions are provided on how to use the > 100 compounds (including negative controls) compiled here to address specificity, adversity and use of alternative test systems. C1 [Aschner, Michael] Albert Einstein Coll Med, New York, NY USA. [Ceccatelli, Sandra] Karolinska Inst Stockholm, Dept Neurosci, Stockholm, Sweden. [Daneshian, Mardas; Hasiwa, Nina; Hartung, Thomas; Leist, Marcel] Univ Konstanz, Ctr Alternat Anim Testing Europe CAAT Europe, Constance, Germany. [Hartung, Thomas; Hogberg, Helena T.] Leibniz Res Inst Environm Med IUF, Dusseldorf, Germany. [Leist, Marcel] Univ Konstanz, Dept Inaugurated Doerenkamp Zbinden Fdn, Vitro Toxicol & Biomedicine, Constance, Germany. [Mundy, William R.; Padilla, Stephanie] NHEERL, US EPA, Res Triangle Pk, Res Triangle Pk, NC USA. [Piersma, Aldert H.] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands. [Piersma, Aldert H.] Exponent Inc, San Francisco, CA USA. [Mundy, William R.; Padilla, Stephanie] NHEERL, US EPA, Res Triangle Pk, NC USA. [Piersma, Aldert H.] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands. [Piersma, Aldert H.] Univ Utrecht, Inst Risk Assessment Sci, Fac Vet Med, Utrecht, Netherlands. [Bal-Price, Anna] European Commiss Joint Res Ctr, Inst Hlth & Consumer Protect, Ispra, Italy. [Leist, Marcel; Seiler, Andrea] BfR Fed Inst Risk Assessment, Berlin, Germany. [Leist, Marcel; Westerink, Remco H.] Univ Utrecht, Inst Risk Assessment Sci IRAS, Res Grp, Utrecht, Netherlands. [Leist, Marcel; Zimmer, Bastian] Axiogenesis AG, Cologne, Germany. [Leist, Marcel; Lein, Pamela J.] Oregon Hlth & Sci Univ, Ctr Res Occupat & Environm Toxicol, Portland, OR USA. [Leist, Marcel; Lein, Pamela J.] Univ Calif Davis, Dept Mol Biosci, Davis, CA USA. RP Leist, M (reprint author), Univ Konstanz, Fdn Univ Konstanz, Dept Inaugurated Doerenkamp Zbinden, Vitro Toxicol & Biomed, Box M657, D-78457 Constance, Germany. EM marcel.leist@uni-konstanz.de FU CAAT-Europe; DZF [RTG1331]; National Institutes of Health [R01 ES07331, R01 ES10563, R01 ES020852, P01 ES011269, R01 ES014901]; United States Environmental Protection Agency [RD835550, RD83543201] FX The workshop was organized and sponsored by CAAT-Europe and DZF. The work of the authors was supported by various grants and home institution funds. They are grateful to EU-ToxRisk, the BMBF and the DFG (RTG1331, KoRS-CB, Memosystems). MA was supported in part by grants from the National Institutes of Health (R01 ES07331, R01 ES10563 and R01 ES020852). PL was supported in part by grants from the National Institutes of Health (P01 ES011269 and R01 ES014901) and the United States Environmental Protection Agency (RD835550 and RD83543201). NR 225 TC 0 Z9 0 U1 0 U2 0 PU SPEKTRUM AKADEMISCHER VERLAG-SPRINGER-VERLAG GMBH PI HEILDEBERG PA TIERGARTENSTRASSE 17, HEILDEBERG, 69121, GERMANY SN 1868-596X EI 1868-8551 J9 ALTEX-ALTERN ANIM EX JI ALTEX-Altern. Anim. Exp. PY 2017 VL 34 IS 1 BP 49 EP 74 DI 10.14573/altex.1604201 PG 26 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA EO3RU UT WOS:000396612700004 PM 27452664 ER PT J AU Smith, AMS Talhelm, AF Johnson, DM Sparks, AM Kolden, CA Yedinak, KM Apostol, KG Tinkham, WT Abatzoglou, JT Lutz, JA Davis, AS Pregitzer, KS Adams, HD Kremens, RL AF Smith, Alistair M. S. Talhelm, Alan F. Johnson, Daniel M. Sparks, Aaron M. Kolden, Crystal A. Yedinak, Kara M. Apostol, Kent G. Tinkham, Wade T. Abatzoglou, John T. Lutz, James A. Davis, Anthony S. Pregitzer, Kurt S. Adams, Henry D. Kremens, Robert L. TI Effects of fire radiative energy density dose on Pinus contorta and Larix occidentalis seedling physiology and mortality SO INTERNATIONAL JOURNAL OF WILDLAND FIRE LA English DT Article DE carbon; FRED; intensity; photosynthesis; recovery; severity ID YOSEMITE-NATIONAL-PARK; PONDEROSA PINE; PRESCRIBED FIRE; CLIMATE-CHANGE; UNITED-STATES; POSTFIRE MORTALITY; PACIFIC-NORTHWEST; QUERCUS SEEDLINGS; FUEL CONSUMPTION; GAS-EXCHANGE AB Climate change is projected to exacerbate the intensity of heat waves and drought, leading to a greater incidence of large and high-intensity wildfires in forested ecosystems. Predicting responses of seedlings to such fires requires a process-based understanding of how the energy released during fires affects plant physiology and mortality. Understanding what fire `doses' cause seedling mortality is important for maintaining grasslands or promoting establishment of desirable plant species. We conducted controlled laboratory combustion experiments on replicates of well-watered nursery-grown seedlings. We evaluated the growth, mortality and physiological response of Larix occidentalis and Pinus contorta seedlings to increasing fire radiative energy density (FRED) doses created using natural fuels with known combustion properties. We observed a general decline in the size and physiological performance of both species that scaled with increasing FRED dose, including decreases in leaf-level photosynthesis, seedling leaf area and diameter at root collar. Greater FRED dose increased the recovery time of chlorophyll fluorescence in the remaining needles. This study provides preliminary data on what level of FRED causes mortality in these two species, which can aid land managers in identifying strategies to maintain (or eliminate) woody seedlings of interest. C1 [Smith, Alistair M. S.; Talhelm, Alan F.; Johnson, Daniel M.; Sparks, Aaron M.; Kolden, Crystal A.; Yedinak, Kara M.; Davis, Anthony S.; Pregitzer, Kurt S.] Univ Idaho, Coll Nat Resources, Moscow, ID 83844 USA. [Talhelm, Alan F.] US EPA, Oak Ridge Inst Sci Educ, Natl Ctr Environm Assessment, Res Triangle Pk, NC USA. [Apostol, Kent G.] Univ Arizona, Coll Agr & Life Sci, Payson, AZ 85541 USA. [Tinkham, Wade T.] Colorado State Univ, Warner Coll Nat Resources, Ft Collins, CO 80523 USA. [Abatzoglou, John T.] Univ Idaho, Coll Sci, Moscow, ID 83844 USA. [Lutz, James A.] Utah State Univ, Wildland Resources, Logan, UT 84322 USA. [Adams, Henry D.] Oklahoma State Univ, Dept Bot, 104 Life Sci Bldg East, Stillwater, OK 74078 USA. [Kremens, Robert L.] Rochester Inst Technol, Carlson Ctr Imaging Sci, New York, NY 14623 USA. RP Smith, AMS (reprint author), Univ Idaho, Coll Nat Resources, Moscow, ID 83844 USA. EM alistair@uidaho.edu FU National Science Foundation [1520873, IIA-1301792, IOS-1146751]; National Aeronautics and Space Administration (NASA) [NNX11AO24G]; Idaho Space Grant Consortium FX Smith, Talhelm, Johnson and Sparks contributed equally to this paper. Smith, Sparks, Kolden, Abatzoglou and Yedinak were funded by the National Science Foundation under award 1520873. Smith was partially funded by the National Aeronautics and Space Administration (NASA) under award NNX11AO24G and the National Science Foundation under award IIA-1301792. Alan Talhelm and Kurt Pregitzer were partially supported by the National Science Foundation under award DEB-1251441. Daniel Johnson was partially supported by an award from the National Science Foundation under award IOS-1146751. Sparks was additionally funded through the Idaho Space Grant Consortium. The views expressed in this paper are those of the authors and do not necessarily represent the views or policies of the USA Environmental Protection Agency. NR 90 TC 1 Z9 1 U1 0 U2 0 PU CSIRO PUBLISHING PI CLAYTON PA UNIPARK, BLDG 1, LEVEL 1, 195 WELLINGTON RD, LOCKED BAG 10, CLAYTON, VIC 3168, AUSTRALIA SN 1049-8001 EI 1448-5516 J9 INT J WILDLAND FIRE JI Int. J. Wildland Fire PY 2017 VL 26 IS 1 BP 82 EP 94 DI 10.1071/WF16077 PG 13 WC Forestry SC Forestry GA EK8EG UT WOS:000394156100008 ER PT J AU Sparks, AM Smith, AMS Talhelm, AF Kolden, CA Yedinak, KM Johnson, DM AF Sparks, Aaron M. Smith, Alistair M. S. Talhelm, Alan F. Kolden, Crystal A. Yedinak, Kara M. Johnson, Daniel M. TI Impacts of fire radiative flux on mature Pinus ponderosa growth and vulnerability to secondary mortality agents SO INTERNATIONAL JOURNAL OF WILDLAND FIRE LA English DT Article DE conifers; fire behaviour; fire severity; post-fire impacts. ID POSTFIRE TREE MORTALITY; BARK BEETLES; PRESCRIBED-FIRE; RESTORATION TREATMENTS; MODIS OBSERVATIONS; FUEL CONSUMPTION; WESTERN MONTANA; ENERGY DENSITY; FOREST-FIRES; SEVERITY AB Recent studies have highlighted the potential of linking fire behaviour to plant ecophysiology as an improved route to characterising severity, but research to date has been limited to laboratory-scale investigations. Fine-scale fire behaviour during prescribed fires has been identified as a strong predictor of post-fire tree recovery and growth, but most studies report these metrics averaged over the entire fire. Previous research has found inconsistent effects of low-intensity fire on mature Pinus ponderosa growth. In this study, fire behaviour was quantified at the tree scale and compared with post-fire radial growth and axial resin duct defences. Results show a clear dose-response relationship between peak fire radiative power per unit area (Wm(-2)) and post-fire Pinus ponderosa radial growth. Unlike in previous laboratory research on seedlings, there was no dose-response relationship observed between fire radiative energy per unit area ( J m(-2)) and post-fire mature tree growth in the surviving trees. These results may suggest that post-fire impacts on growth of surviving seedlings and mature trees require other modes of heat transfer to impact plant canopies. This study demonstrates that increased resin duct defence is induced regardless of fire intensity, which may decrease Pinus ponderosa vulnerability to secondary mortality agents. C1 [Sparks, Aaron M.; Smith, Alistair M. S.; Talhelm, Alan F.; Kolden, Crystal A.; Yedinak, Kara M.; Johnson, Daniel M.] Univ Idaho, Dept Forest Rangeland & Fire Sci, Moscow, ID 83844 USA. [Talhelm, Alan F.] US EPA, Oak Ridge Inst Sci Educ, Natl Ctr Environm Assessment, Res Triangle Pk, NC USA. RP Sparks, AM (reprint author), Univ Idaho, Dept Forest Rangeland & Fire Sci, Moscow, ID 83844 USA. EM spar5010@vandals.uidaho.edu FU National Science Foundation under Hazards Science, Engineering and Educationfor Sustainability award [1520873]; Idaho Space Grant Consortium; Joint Fire Science Program GRIN Award [16-2-01-09, 13-1-05-7]; National Institute of Food and Agriculture, USDA, McIntire Stennis project [1004149]; Idaho Experimental Program to Stimulate Competitive Research; National Science Foundation [IIA-1301792] FX Partial funding for this research for Sparks, Kolden and Smith was provided by the National Science Foundation under Hazards Science, Engineering and Education for Sustainability award no. 1520873. Sparks was additionally funded through the Idaho Space Grant Consortium and Joint Fire Science Program GRIN Award 16-2-01-09 and Award 13-1-05-7. This work is based on work that is partially supported by the National Institute of Food and Agriculture, USDA, McIntire Stennis project under 1004149. Smith was partially supported by the Idaho Experimental Program to Stimulate Competitive Research and by the National Science Foundation under award number IIA-1301792. The views expressed in this paper are those of the authors and do not necessarily reflect the views or policies of the US Environmental Protection Agency. NR 66 TC 1 Z9 1 U1 0 U2 0 PU CSIRO PUBLISHING PI CLAYTON PA UNIPARK, BLDG 1, LEVEL 1, 195 WELLINGTON RD, LOCKED BAG 10, CLAYTON, VIC 3168, AUSTRALIA SN 1049-8001 EI 1448-5516 J9 INT J WILDLAND FIRE JI Int. J. Wildland Fire PY 2017 VL 26 IS 1 BP 95 EP 106 DI 10.1071/WF16139 PG 12 WC Forestry SC Forestry GA EK8EG UT WOS:000394156100009 ER PT J AU You, ZQ Zhu, Y Jang, C Wang, SX Gao, J Lin, CJ Li, MH Zhu, ZH Wei, H Yang, WW AF You, Zhiqiang Zhu, Yun Jang, Carey Wang, Shuxiao Gao, Jian Lin, Che-Jen Li, Minhui Zhu, Zhenghua Wei, Hao Yang, Wenwei TI Response surface modeling-based source contribution analysis and VOC emission control policy assessment in a typical ozone-polluted urban Shunde, China SO JOURNAL OF ENVIRONMENTAL SCIENCES LA English DT Article DE O-3; Response surface model; Source contribution analysis; VOCs control policy ID VOLATILE ORGANIC-COMPOUNDS; PEARL RIVER DELTA; AIR-QUALITY; PRIDE-PRD2004 CAMPAIGN; ATTAINMENT ASSESSMENT; SYSTEM; IMPACT; PM2.5; NOX; O-3 AB To develop a sound ozone (O-3) pollution control strategy, it is important to well understand and characterize the source contribution due to the complex chemical and physical formation processes of O-3. Using the "Shunde" city as a pilot summer case study, we apply an innovative response surface modeling (RSM) methodology based on the Community Multi-Scale Air Quality (CMAQ) modeling simulations to identify the O-3 regime and provide dynamic analysis of the precursor contributions to effectively assess the O-3 impacts of volatile organic compound (VOC) control strategy. Our results show that Shunde is a typical VOC-limited urban O-3 polluted city. The "Jiangmen" city, as the main upper wind area during July 2014, its VOCs and nitrogen oxides (NOx) emissions make up the largest contribution (9.06%). On the contrary, the contribution from local (Shunde) emission is lowest (6.35%) among the seven neighbor regions. The local VOCs industrial source emission has the largest contribution comparing to other precursor emission sectors in Shunde. The results of dynamic source contribution analysis further show that the local NOx control could slightly increase the ground O-3 under low (10.00%) and medium (40.00%) reduction ratios, while it could start to turn positive to decrease ground O-3 under the high NOx abatement ratio (75.00%). The real-time assessment of O-3 impacts from VOCs control strategies in Pearl River Delta (PRD) shows that the joint regional VOCs emission control policy will effectively reduce the ground O-3 concentration in Shunde. (C) 2016 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V. C1 [You, Zhiqiang; Zhu, Yun; Li, Minhui; Wei, Hao; Yang, Wenwei] South China Univ Technol, Guangzhou Higher Educ Mega Ctr, Coll Environm & Energy, Guangdong Prov Key Lab Atmospher Environm & Pollu, Guangzhou 510006, Guangdong, Peoples R China. [Zhu, Yun; Wang, Shuxiao] Tsinghua Univ, Sch Environm, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100084, Peoples R China. [Jang, Carey] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA. [Gao, Jian] Chinese Res Inst Environm Sci, Beijing 100012, Peoples R China. [Lin, Che-Jen] Lamar Univ, Dept Civil Engn, Beaumont, TX 77710 USA. [Zhu, Zhenghua] Guangzhou Urban Environm Cloud Informat Technol R, Guangzhou 511400, Guangdong, Peoples R China. RP Zhu, Y (reprint author), South China Univ Technol, Guangzhou Higher Educ Mega Ctr, Coll Environm & Energy, Guangdong Prov Key Lab Atmospher Environm & Pollu, Guangzhou 510006, Guangdong, Peoples R China.; Zhu, Y (reprint author), Tsinghua Univ, Sch Environm, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100084, Peoples R China.; Gao, J (reprint author), Chinese Res Inst Environm Sci, Beijing 100012, Peoples R China. EM zhuyun@scut.edu.cn; gaojian@craes.org.cn FU Shunde Environment Protection, Transportation and Urban Administration Bureau [0851-1361FS02CL51]; Guangdong Provincial Science and Technology Plan Projects [2014A050503019]; Guangzhou Environmental Protection Bureau [x2hjB2150020]; State Environmental Protection Key Laboratory of Sources and Control of Air Pollution Complex; project of Atmospheric Haze Collaboration Control Technology Design from Chinese Academy of Sciences [XDB05030400]; Special Program for Applied Research on Super Computation of the NSFC-Guangdong Joint Fund [U1501501]; Guangdong Provincial Engineering and Technology Research Center for Environmental Risk Prevention and Emergency Disposal [b2152120] FX Financial support for this work is provided by the Shunde Environment Protection, Transportation and Urban Administration Bureau (no. 0851-1361FS02CL51), the Guangdong Provincial Science and Technology Plan Projects (no. 2014A050503019) and Guangzhou Environmental Protection Bureau (no. x2hjB2150020). This work is also partly supported by the funding of State Environmental Protection Key Laboratory of Sources and Control of Air Pollution Complex, the project of Atmospheric Haze Collaboration Control Technology Design (no. XDB05030400) from Chinese Academy of Sciences, the Special Program for Applied Research on Super Computation of the NSFC-Guangdong Joint Fund (U1501501) (the second phase), and the Guangdong Provincial Engineering and Technology Research Center for Environmental Risk Prevention and Emergency Disposal (no. b2152120). NR 31 TC 0 Z9 0 U1 5 U2 5 PU SCIENCE PRESS PI BEIJING PA 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA SN 1001-0742 EI 1878-7320 J9 J ENVIRON SCI-CHINA JI J. Environ. Sci. PD JAN 1 PY 2017 VL 51 BP 294 EP 304 DI 10.1016/j.jes.2016.05.034 PG 11 WC Environmental Sciences SC Environmental Sciences & Ecology GA EL8JH UT WOS:000394865600030 PM 28115141 ER PT J AU Mannshardt, E Benedict, K Jenkins, S Keating, M Mintz, D Stone, S Wayland, R AF Mannshardt, Elizabeth Benedict, Kristen Jenkins, Scott Keating, Martha Mintz, David Stone, Susan Wayland, Richard TI Analysis of short-term ozone and PM2.5 measurements: Characteristics and relationships for air sensor messaging SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION LA English DT Article ID NORTH-CAROLINA; POLLUTION; MORTALITY; EXPOSURE; COUNTIES AB Air quality sensors are becoming increasingly available to the general public, providing individuals and communities with information on fine-scale, local air quality in increments as short as 1 min. Current health studies do not support linking 1-min exposures to adverse health effects; therefore, the potential health implications of such ambient exposures are unclear. The U.S. Environmental Protection Agency (EPA) establishes the National Ambient Air Quality Standards (NAAQS) and Air Quality Index (AQI) on the best science available, which typically uses longer averaging periods (e.g., 8 hr; 24 hr). Another consideration for interpreting sensor data is the variable relationship between pollutant concentrations measured by sensors, which are short-term (1 min to 1 hr), and the longer term averages used in the NAAQS and AQI. In addition, sensors often do not meet federal performance or quality assurance requirements, which introduces uncertainty in the accuracy and interpretation of these readings. This article describes a statistical analysis of data from regulatory monitors and new real-time technology from Village Green benches to inform the interpretation and communication of short-term air sensor data. We investigate the characteristics of this novel data set and the temporal relationships of short-term concentrations to 8-hr average (ozone) and 24-hr average (PM2.5) concentrations to examine how sensor readings may relate to the NAAQS and AQI categories, and ultimately to inform breakpoints for sensor messages. We consider the empirical distributions of the maximum 8-hr averages (ozone) and 24-hr averages (PM2.5) given the corresponding short-term concentrations, and provide a probabilistic assessment. The result is a robust, empirical comparison that includes events of interest for air quality exceedances and public health communication. Concentration breakpoints are developed for short-term sensor readings such that, to the extent possible, the related air quality messages that are conveyed to the public are consistent with messages related to the NAAQS and AQI. Implications: Real-time sensors have the potential to provide important information about fine-scale current air quality and local air quality events. The statistical analysis of short-term regulatory and sensor data, coupled with policy considerations and known health effects experienced over longer averaging times, supports interpretation of such short-term data and efforts to communicate local air quality. C1 [Mannshardt, Elizabeth; Benedict, Kristen; Jenkins, Scott; Keating, Martha; Mintz, David; Stone, Susan; Wayland, Richard] US Environm Protect Agcy, 109 TW Alexander Dr,C304-04, Res Triangle Pk, NC 27709 USA. RP Mannshardt, E (reprint author), US Environm Protect Agcy, 109 TW Alexander Dr,C304-04, Res Triangle Pk, NC 27709 USA. EM mannshardt.elizabeth@epa.gov NR 21 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1096-2247 EI 2162-2906 J9 J AIR WASTE MANAGE JI J. Air Waste Manage. Assoc. PY 2017 VL 67 IS 4 BP 462 EP 474 DI 10.1080/10962247.2016.1251995 PG 13 WC Engineering, Environmental; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA EO6EV UT WOS:000396785600007 PM 27808658 ER PT J AU Parsons, M Thoms, MC Flotemersch, JE AF Parsons, Melissa Thoms, Martin C. Flotemersch, Joseph E. TI Eight river principles for navigating the science-policy interface SO MARINE AND FRESHWATER RESEARCH LA English DT Review DE Murray-Darling Basin; river management; social-ecological systems; water policy ID NATURAL-RESOURCE MANAGEMENT; ECOSYSTEM SERVICES; WATER MANAGEMENT; FRESH-WATER; ECOLOGY; GEOMORPHOLOGY; FRAMEWORK AB Scientists and policymakers often work together to develop policy about the sustainable use of river ecosystems. River science plays an important role in developing river policy but how can key aspects of river science be conveyed as a heuristic to navigate the interface between river science and river policy? This paper introduces eight principles that encapsulate the key properties of rivers to consider during the development of river policy: (1) rivers are social-ecological systems; (2) river ecosystems provide valuable ecosystem services; (3) tools should support policy development; (4) knowledge of river ecosystems will always be incomplete; (5) social-ecological systems require interdisciplinary perspectives; (6) science is one of many inputs to be considered; (7) heterogeneity and variability are characteristic of river ecosystems; and (8) scale awareness is essential in river ecosystems. Whereas policy challenges are associated with each principle, consideration of principles in the context of the issue at hand may increase the robustness of river policy and enhance the sustainability of river ecosystems. The eight principles are evaluated in relation to the Water Act 2007 and the draft Murray-Darling Basin Plan to demonstrate how the principles can enhance policy development in the area of water allocation. C1 [Parsons, Melissa; Thoms, Martin C.] Univ New England, Geog & Planning, Riverine Landscapes Res Lab, Armidale, NSW 2351, Australia. [Flotemersch, Joseph E.] US EPA, Natl Exposure Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. RP Thoms, MC (reprint author), Univ New England, Geog & Planning, Riverine Landscapes Res Lab, Armidale, NSW 2351, Australia. EM martin.thoms@une.edu.au FU Fulbright Senior Scholarship; US EPA [GS-35F-4594G] FX We thank Prof. Mike Delong (Winona State University, MN) for hosting us while preparing this manuscript. M. C. Thoms was supported by a Fulbright Senior Scholarship. Graphics support was provided by Teresa Ruby under SRA International Inc. US EPA contract GS-35F-4594G. Dr Mark Southwell and Dr Ken Lubinski contributed comments on early versions of the manuscript and the comments of anonymous reviewers greatly improved this manuscript. The views expressed in this article are those of the author(s) and do not necessarily reflect the views or policies of the US EPA. NR 61 TC 0 Z9 0 U1 1 U2 1 PU CSIRO PUBLISHING PI CLAYTON PA UNIPARK, BLDG 1, LEVEL 1, 195 WELLINGTON RD, LOCKED BAG 10, CLAYTON, VIC 3168, AUSTRALIA SN 1323-1650 EI 1448-6059 J9 MAR FRESHWATER RES JI Mar. Freshw. Res. PY 2017 VL 68 IS 3 BP 401 EP 410 DI 10.1071/MF15336 PG 10 WC Fisheries; Limnology; Marine & Freshwater Biology; Oceanography SC Fisheries; Marine & Freshwater Biology; Oceanography GA EN5II UT WOS:000396038400001 ER PT J AU Bandara, SB Sadowski, RN Schantz, SL Gilbert, ME AF Bandara, Suren B. Sadowski, Renee N. Schantz, Susan L. Gilbert, Mary E. TI Developmental exposure to an environmental PCB mixture delays the propagation of electrical kindling from the amygdala SO NEUROTOXICOLOGY LA English DT Article DE PCBs; Amygdala kindling; Seizures ID LONG-TERM POTENTIATION; POLYCHLORINATED-BIPHENYLS; AUDIOGENIC-SEIZURES; INHIBITORY INTERNEURONS; SYNAPTIC-TRANSMISSION; INFERIOR COLLICULUS; LATERAL AMYGDALA; DENDRITIC GROWTH; DENTATE GYRUS; AROCLOR 1254 AB Developmental PCB exposure impairs hearing and induces brainstem audiogenic seizures in adult offspring. The degree to which this enhanced susceptibility to seizure is manifest in other brain regions has not been examined. Thus, electrical kindling of the amygdala was used to evaluate the effect of developmental exposure to an environmentally relevant PCB mixture on seizure susceptibility in the rat. Female Long-Evans rats were dosed orally with 0 or 6 mg/kg/day of the PCB mixture dissolved in corn oil vehicle 4 weeks prior to mating and continued through gestation and up until postnatal day (PND) 21. On PND 21, pups were weaned, and two males from each litter were randomly selected for the kindling study. As adults, the male rats were implanted bilaterally with electrodes in the basolateral amygdala. For each animal, afterdischarge (AD) thresholds in the amygdala were determined on the first day of testing followed by once daily stimulation at a standard 200 A stimulus intensity until three stage 5 generalized seizures (GS) ensued. Developmental PCB exposure did not affect the AD threshold or total cumulative AD duration, but PCB exposure did increase the latency to behavioral manifestations of seizure propagation. PCB exposed animals required significantly more stimulations to reach stage 2 seizures compared to control animals, indicating attenuated focal (amygdala) excitability. A delay in kindling progression in the amygdala stands in contrast to our previous finding of increased susceptibility to brainstem-mediated audiogenic seizures in PCB-exposed animals in response to a an intense auditory stimulus. These seemingly divergent results are not unexpected given the distinct source, type, and mechanistic underpinnings of these different seizure models. A delay in epileptogenesis following focal amygdala stimulation may reflect a decrease in neuroplasticity following developmental PCB exposure consistent with reductions in use-dependent synaptic plasticity that have been reported in the hippocampus of developmentally PCB exposed animals. (C) 2016 Elsevier B.V. All rights reserved. C1 [Bandara, Suren B.; Sadowski, Renee N.; Schantz, Susan L.] Univ Illinois, Neurosci Program, Urbana, IL 61802 USA. [Sadowski, Renee N.; Schantz, Susan L.] Univ Illinois, Beckman Inst, Urbana, IL 60801 USA. [Schantz, Susan L.] Univ Illinois, Dept Comparat Biosci, Urbana, IL 61802 USA. [Gilbert, Mary E.] US EPA, Res Triangle Pk, NC 27711 USA. RP Bandara, SB (reprint author), Univ Calif Davis, Dept Mol Biosci, 1089 Vet Med Dr,VM3B, Davis, CA 95616 USA. EM sbandara@ucdavis.edu FU National Institute of Environmental Health Sciences (NIEHS) [R01 ES015687] FX This document has been subjected to review by the National Health and Environmental Effects Research Laboratory and approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. The authors would like to thank Drs. Larry G. Hansen and Paul J. Kostyniak for their help in formulating the PCB mixture and Charles Hamm for technical support with the kindling setup and for developing custom NI software. This work was supported by a grant from the National Institute of Environmental Health Sciences (NIEHS) [R01 ES015687 to SLS]. NR 48 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0161-813X EI 1872-9711 J9 NEUROTOXICOLOGY JI Neurotoxicology PD JAN PY 2017 VL 58 BP 42 EP 49 DI 10.1016/j.neuro.2016.10.016 PG 8 WC Neurosciences; Pharmacology & Pharmacy; Toxicology SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology GA EL1UJ UT WOS:000394406400004 PM 27816614 ER PT J AU Allen, ST Keim, RF Barnard, HR McDonnell, JJ Brooks, JR AF Allen, Scott T. Keim, Richard F. Barnard, Holly R. McDonnell, Jeffrey J. Brooks, J. Renee TI The role of stable isotopes in understanding rainfall interception processes: a review SO WILEY INTERDISCIPLINARY REVIEWS-WATER LA English DT Review ID SOIL-WATER; CANOPY INTERCEPTION; SPATIAL VARIABILITY; THROUGHFALL PATTERNS; STEMFLOW GENERATION; DESERT SHRUBS; FOREST CANOPY; FLOW PATHWAYS; PINE FOREST; EVAPORATION AB The isotopic composition of water transmitted by the canopy as throughfall or stemflow reflects a suite of processes modifying rainfall. Factors that affect isotopic composition of canopy water include fractionation, exchange between liquid and vapor, and selective transmittance of temporally varying rainfall along varying canopy flowpaths. Despite frequent attribution of canopy effects on isotopic composition of throughfall to evaporative fractionation, data suggest exchange and selection are more likely the dominant factors. Temporal variability in canopy effects is generally consistent with either exchange or selection, but spatial variability is generally more consistent with selection. However, most investigations to date have not collected data sufficient to unambiguously identify controlling processes. Using isotopic data for improved understanding of physical processes and water routing in the canopy requires recognizing how these factors and processes lead to patterns of isotopic variability, and then applying this understanding toward focused data collection and analysis. (C) 2016 Wiley Periodicals, Inc. C1 [Allen, Scott T.; Keim, Richard F.] Louisiana State Univ, Sch Renewable Nat Resources, Baton Rouge, LA 70803 USA. [Barnard, Holly R.] Univ Colorado, Dept Geog, Inst Arctic & Alpine Res, Boulder, CO 80309 USA. [McDonnell, Jeffrey J.] Univ Saskatchewan, Sch Environm & Sustainabil, Saskatoon, SK, Canada. [McDonnell, Jeffrey J.] Univ Saskatchewan, Global Inst Water Secur, Saskatoon, SK, Canada. [McDonnell, Jeffrey J.] Univ Aberdeen, Sch Geosci, Aberdeen, Scotland. [Brooks, J. Renee] US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR USA. RP Allen, ST (reprint author), Louisiana State Univ, Sch Renewable Nat Resources, Baton Rouge, LA 70803 USA. EM Scottallen1@gmail.com NR 82 TC 0 Z9 0 U1 0 U2 0 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA EI 2049-1948 J9 WIRES-WATER JI Wiley Interdiscip. Rev.-Water PD JAN-FEB PY 2017 VL 4 IS 1 AR UNSP e1187 DI 10.1002/wat2.1187 PG 17 WC Water Resources SC Water Resources GA EL8XW UT WOS:000394904700009 ER PT J AU Creutzburg, MK Scheller, RM Lucash, MS LeDuc, SD Johnson, MG AF Creutzburg, Megan K. Scheller, Robert M. Lucash, Melissa S. LeDuc, Stephen D. Johnson, Mark G. TI Forest management scenarios in a changing climate: trade-offs between carbon, timber, and old forest SO ECOLOGICAL APPLICATIONS LA English DT Article DE carbon; climate change; ecological forestry; forest ecology; LANDIS-II; landscape modeling; Northwest Forest Plan; Oregon Coast Range; retention harvest; wildfire ID WESTERN UNITED-STATES; OREGON COAST RANGE; LANDSCAPE SIMULATION-MODEL; PACIFIC-NORTHWEST; DOUGLAS-FIR; RESTORATION FRAMEWORK; MANAGING FORESTS; FEDERAL FORESTS; SPATIAL SCALES; GROWTH AB Balancing economic, ecological, and social values has long been a challenge in the forests of the Pacific Northwest, where conflict over timber harvest and old-growth habitat on public lands has been contentious for the past several decades. The Northwest Forest Plan, adopted two decades ago to guide management on federal lands, is currently being revised as the region searches for a balance between sustainable timber yields and habitat for sensitive species. In addition, climate change imposes a high degree of uncertainty on future forest productivity, sustainability of timber harvest, wildfire risk, and species habitat. We evaluated the long-term, landscape-scale trade-offs among carbon (C) storage, timber yield, and old forest habitat given projected climate change and shifts in forest management policy across 2.1 million hectares of forests in the Oregon Coast Range. Projections highlight the divergence between private and public lands under business-as-usual forest management, where private industrial forests are heavily harvested and many public (especially federal) lands increase C and old forest over time but provide little timber. Three alternative management scenarios altering the amount and type of timber harvest show widely varying levels of ecosystem C and old-forest habitat. On federal lands, ecological forestry practices also allowed a simultaneous increase in old forest and natural early-seral habitat. The ecosystem C implications of shifts away from current practices were large, with current practices retaining up to 105Tg more C than the alternative scenarios by the end of the century. Our results suggest climate change is likely to increase forest productivity by 30-41% and total ecosystem C storage by 11-15% over the next century as warmer winter temperatures allow greater forest productivity in cooler months. These gains in C storage are unlikely to be offset by wildfire under climate change, due to the legacy of management and effective fire suppression. Our scenarios of future conditions can inform policy makers, land managers, and the public about the potential effects of land management alternatives, climate change, and the trade-offs that are inherent to management and policy in the region. C1 [Creutzburg, Megan K.; Scheller, Robert M.; Lucash, Melissa S.] Portland State Univ, Dept Environm Sci & Management, POB 751, Portland, OR 97207 USA. [LeDuc, Stephen D.] US EPA, Natl Ctr Environm Assessment, 1200 Penn Ave NW 8623P, Washington, DC 20460 USA. [Johnson, Mark G.] US EPA, Natl Hlth & Environm Effects Res Lab, 200 SW 35th St, Corvallis, OR 97333 USA. [Creutzburg, Megan K.] Oregon State Univ, Inst Nat Resources, POB 751, Portland, OR 97207 USA. RP Creutzburg, MK (reprint author), Portland State Univ, Dept Environm Sci & Management, POB 751, Portland, OR 97207 USA.; Creutzburg, MK (reprint author), Oregon State Univ, Inst Nat Resources, POB 751, Portland, OR 97207 USA. EM megan.creutzburg@oregonstate.edu RI Scheller, Robert/B-3135-2009 FU U.S. Bureau of Land Management and Environmental Protection Agency [DW-14-95829801-0] FX Funding was provided by the U.S. Bureau of Land Management and Environmental Protection Agency Interagency Agreement DW-14-95829801-0. Thanks to George McFadden and Louisa Evers of the Bureau of Land Management, and Greg Johnson, David Marshall, and Scott Holub of Weyerhaeuser for their input. Many thanks to representatives from the Environmental Protection Agency, Bureau of Land Management, U.S. Forest Service, Oregon Department of Forestry, Grand Ronde tribe, Oregon Wild, Oregon State University, and others who attended the management scenario workshop and assisted in developing management scenarios. Thanks also to the Landscape Ecology, Modeling, Mapping, and Analysis team for providing vegetation maps and biomass estimates, and Steve Campbell of NRCS for assistance with soil data processing. Alec Kretchun and Lesley Bross provided instrumental programming support. Thanks to Peter Beedlow and Ellen Cooter of the U.S. Environmental Protection Agency, and reviewers for their feedback on earlier versions of this manuscript. The views expressed here are those of the authors and do not necessarily represent the views or policies of the U.S. Environmental Protection Agency or Bureau of Land Management. NR 101 TC 0 Z9 0 U1 5 U2 5 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1051-0761 EI 1939-5582 J9 ECOL APPL JI Ecol. Appl. PY 2017 VL 27 IS 2 BP 503 EP 518 DI 10.1002/eap.1460 PG 16 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA EM9LY UT WOS:000395634300015 PM 27767233 ER PT J AU Wang, P Lombi, E Sun, SK Scheckel, KG Malysheva, A McKenna, BA Menzies, NW Zhao, FJ Kopittke, PM AF Wang, Peng Lombi, Enzo Sun, Shengkai Scheckel, Kirk G. Malysheva, Anzhela McKenna, Brigid A. Menzies, Neal W. Zhao, Fang-Jie Kopittke, Peter M. TI Characterizing the uptake, accumulation and toxicity of silver sulfide nanoparticles in plants SO ENVIRONMENTAL SCIENCE-NANO LA English DT Article ID PLASMA-MASS SPECTROMETRY; CUCUMBER CUCUMIS-SATIVUS; SEWAGE-SLUDGE; WASTE-WATER; ENGINEERED NANOPARTICLES; ARABIDOPSIS-THALIANA; GOLD NANOPARTICLES; ZNO NANOPARTICLES; TRANS LOCATION; PUMPKIN PLANTS AB Silver nanoparticles (Ag-NPs) are used in a wide range of everyday products, leading to increasing concerns regarding their accumulation in soils and subsequent impact on plants. Using single particle inductively coupled plasma mass spectrometry (spICP-MS) and synchrotron-based techniques including X-ray absorption spectroscopy (XAS) and X-ray fluorescence microscopy (XFM), we characterized the uptake, speciation, and translocation of insoluble Ag2S-NPs (an environmentally-relevant form of Ag-NPs in soils) within two plant species, a monocot and a dicot. Exposure to 10 mg Ag L-1 as Ag2S-NPs for one week resulted in a substantial increase in leaf Ag concentrations (3.8 to 5.8 mu g Ag g(-1) dry mass). Examination using XAS revealed that most of the Ag was present as Ag2S (> 91%). Furthermore, analyses using spICP-MS confirmed that these Ag2S particles within the leaves had a markedly similar size distribution to those supplied within the hydroponic solution. These observations, for the first time, provide direct evidence that plants take up Ag2S-NPs without a marked selectivity in regard to particle size and without substantial transformation (dissolution or aggregation) during translocation from roots to shoots. Furthermore, after uptake, these Ag(2)SNPs reduced growth, partially due to the solubilisation of Ag+ in planta, which resulted in an upregulation of genes involved in the ethylene signalling pathway. Additionally, the upregulation of the plant defense system as a result of Ag2S-NPs exposure may have contributed to the decrease in plant growth. These results highlight the risks associated with Ag-NP accumulation in plants and subsequent trophic transfer via the food chain. C1 [Wang, Peng; Sun, Shengkai; Zhao, Fang-Jie] Nanjing Agr Univ, Coll Resources & Environm Sci, Nanjing 210095, Jiangsu, Peoples R China. [Wang, Peng; McKenna, Brigid A.; Menzies, Neal W.; Kopittke, Peter M.] Univ Queensland, Sch Agr & Food Sci, St Lucia, Qld 4072, Australia. [Lombi, Enzo; Malysheva, Anzhela] Univ South Australia, Future Ind Inst, Mawson Lakes, SA 5095, Australia. [Scheckel, Kirk G.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. [Malysheva, Anzhela] Univ Copenhagen, Dept Plant & Environm Sci, DK-1165 Copenhagen, Denmark. RP Wang, P (reprint author), Nanjing Agr Univ, Coll Resources & Environm Sci, Nanjing 210095, Jiangsu, Peoples R China.; Wang, P (reprint author), Univ Queensland, Sch Agr & Food Sci, St Lucia, Qld 4072, Australia.; Lombi, E (reprint author), Univ South Australia, Future Ind Inst, Mawson Lakes, SA 5095, Australia. EM p.wang3@njau.edu.cn; Enzo.lombi@unisa.edu.au RI Zhao, Fang-Jie/A-8339-2008; Wang, Peng/E-2008-2012 OI Zhao, Fang-Jie/0000-0002-0164-169X; Wang, Peng/0000-0001-8622-8767 FU Australian Research Council (ARC) DECRA [DE130100943]; ARC Future Fellowship [FT120100277]; GeoSoilEnviroCARS - National Science Foundation - Earth Sciences [EAR-1128799]; Department of Energy, Geosciences [DE-FG02-94ER14466]; International Synchrotron Access Program (ISAP); Australian Government [ISAP152/ISP10150]; US-EPA FX Support was provided to P. Wang as a recipient of an Australian Research Council (ARC) DECRA (DE130100943) and to P. Kopittke as a recipient of an ARC Future Fellowship (FT120100277). Parts of this research were carried out at the XAS Beamline at the Australian Synchrotron, Victoria, Australia (AS153/XAS/9937). We acknowledge the support of GeoSoilEnviroCARS (Sector 13), which is supported by the National Science Foundation - Earth Sciences (EAR-1128799), and the Department of Energy, Geosciences (DE-FG02-94ER14466). We acknowledge travel funding provided by the International Synchrotron Access Program (ISAP) managed by the Australian Synchrotron and funded by the Australian Government (ISAP152/ISP10150). The US-EPA contributed to this article but the research was neither performed nor funded by the US-EPA and is not subject to the US-EPA's quality system requirements. Consequently, the views, interpretations, and conclusions expressed in this article are solely those of the authors and do not necessarily reflect or represent the USEPA's views or policies. The authors would like to acknowledge Dr Matthew Newville from the APS for his assistance. NR 47 TC 0 Z9 0 U1 2 U2 2 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2051-8153 EI 2051-8161 J9 ENVIRON SCI-NANO JI Environ.-Sci. Nano PY 2017 VL 4 IS 2 BP 448 EP 460 DI 10.1039/c6en00489j PG 13 WC Chemistry, Multidisciplinary; Environmental Sciences; Nanoscience & Nanotechnology SC Chemistry; Environmental Sciences & Ecology; Science & Technology - Other Topics GA EN2YK UT WOS:000395876000018 ER PT J AU Phillips, KA Wambaugh, JF Grulke, CM Dionisio, KL Isaacs, KK AF Phillips, Katherine A. Wambaugh, John F. Grulke, Christopher M. Dionisio, Kathie L. Isaacs, Kristin K. TI High-throughput screening of chemicals as functional substitutes using structure-based classification models SO GREEN CHEMISTRY LA English DT Article ID ENVIRONMENTAL CHEMICALS; QSAR MODELS; EXPOSURE; SELECTION; PRIORITIZATION; ALTERNATIVES; PARAMETERS; SOLVENTS; PROJECT AB Identifying chemicals that provide a specific function within a product, yet have minimal impact on the human body or environment, is the goal of most formulation chemists and engineers practicing green chemistry. We present a methodology to identify potential chemical functional substitutes from large libraries of chemicals using machine learning based models. We collect and analyze publicly available information on the function of chemicals in consumer products or industrial processes to identify a suite of harmonized function categories suitable for modeling. We use structural and physicochemical descriptors for these chemicals to build 41 quantitative structure-use relationship (QSUR) models for harmonized function categories using random forest classification. We apply these models to screen a library of nearly 6400 chemicals with available structure information for potential functional substitutes. Using our Functional Use database (FUse), we could identify uses for 3121 chemicals; 4412 predicted functional uses had a probability of 80% or greater. We demonstrate the potential application of the models to high-throughput (HT) screening for "candidate alternatives" by merging the valid functional substitute classifications with hazard metrics developed from HT screening assays for bioactivity. A descriptor set could be obtained for 6356 Tox21 chemicals that have undergone a battery of HT in vitro bioactivity screening assays. By applying QSURs, we were able to identify over 1600 candidate chemical alternatives. These QSURs can be rapidly applied to thousands of additional chemicals to generate HT functional use information for combination with complementary HT toxicity information for screening for greener chemical alternatives. C1 [Phillips, Katherine A.] ORISE, Oak Ridge, TN 37830 USA. [Wambaugh, John F.; Grulke, Christopher M.] US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Phillips, Katherine A.; Dionisio, Kathie L.; Isaacs, Kristin K.] US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. RP Phillips, KA (reprint author), ORISE, Oak Ridge, TN 37830 USA.; Phillips, KA (reprint author), US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. EM phillips.katherine@epa.gov OI Phillips, Katherine/0000-0001-5703-0698 FU United States Environmental Protection Agency, through its Office of Research and Development's Chemical Safety for Sustainability research program FX The United States Environmental Protection Agency, through its Office of Research and Development's Chemical Safety for Sustainability research program, provided funding and managed the research described here. This research was supported in part by an appointment to the Postdoctoral Research Program at the National Exposure Research Laboratory, administered by the Oak Ridge Institute for Science and Education through Interagency Agreement No. DW-89-92298301-0 between the U.S. Department of Energy and the U.S. Environmental Protection Agency. The views expressed in this article are those of the authors and do not necessarily represent the views or policies of the U.S. Environmental Protection Agency. Reference to commercial products or services does not constitute endorsement. The authors would like to thank Drs Brandall Ingle and Antony Williams for their helpful review of the manuscript. NR 40 TC 0 Z9 0 U1 0 U2 0 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1463-9262 EI 1463-9270 J9 GREEN CHEM JI Green Chem. PY 2017 VL 19 IS 4 BP 1063 EP 1074 DI 10.1039/c6gc02744j PG 12 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY SC Chemistry; Science & Technology - Other Topics GA EN2UU UT WOS:000395866600023 ER PT J AU Scott, R Mudimbi, P Miller, ME Magnuson, M Willison, S Phillips, R Harper, WF AF Scott, Robert Mudimbi, Patrick Miller, Michael E. Magnuson, Matthew Willison, Stuart Phillips, Rebecca Harper, Willie F., Jr. TI Advanced Oxidation of Tartrazine and Brilliant Blue with Pulsed Ultraviolet Light Emitting Diodes SO WATER ENVIRONMENT RESEARCH LA English DT Article DE Ultra Violet light-emitting diodes (UV LED); advanced oxidation; tartrazine; brilliant blue; pulsing; rate constants ID WASTE-WATER; INACTIVATION; BEHAVIOR; COLORANT AB This study investigated the effect of ultraviolet light-emitting diodes (UVLEDs) coupled with hydrogen peroxide as an advanced oxidation process (AOP) for the degradation of two test chemicals. Brilliant Blue FCF consistently exhibited greater degradation than tartrazine, with 83% degradation after 300 minutes at the 100% duty cycle compared with only 17% degradation of tartrazine under the same conditions. These differences are attributable to the structural properties of the compounds. Duty cycle was positively correlated with the firstorder rate constants (k) for both chemicals but, interestingly, negatively correlated with the normalized first-order rate constants (k/duty cycle). Synergistic effects of both hydraulic mixing and LED duty cycle were manifested as novel oscillations in the effluent contaminant concentration. Further, LED output and efficiency were dependent upon duty cycle and less efficient over time perhaps due to heating effects on semiconductor performance. C1 [Scott, Robert; Mudimbi, Patrick; Miller, Michael E.; Harper, Willie F., Jr.] Air Force Inst Technol, Dept Syst Engn & Management, 2950 Hobson Way, Wright Patterson AFB, OH 45433 USA. [Magnuson, Matthew; Willison, Stuart] US EPA, Natl Homeland Secur Res Ctr, Water Infrastruct Protect Div, 26 W Martin Luther King Dr,Mailstop NG-16, Cincinnati, OH 45268 USA. [Phillips, Rebecca] US Environm Protect Agcy Headquarters, Oak Ridge Inst Sci & Educ, ML-8801 RR,Room 51185,Ronald Reagan Bldg, Washington, DC 20004 USA. RP Harper, WF (reprint author), Air Force Inst Technol, Dept Syst Engn & Management, 2950 Hobson Way, Wright Patterson AFB, OH 45433 USA. EM willie.harper@afit.edu FU U.S. Environmental Protection Agency through its Office of Research and Development [92370201] FX The views expressed in this article are those of the authors and do not reflect the official policy or position of the Air Force Institute of Technology, United States Air Force, Department of Defense, or United States government. The U.S. Environmental Protection Agency through its Office of Research and Development partially funded and collaborated in the research described here under Interagency Agreement 92370201. It has been subjected to the Agency's review and has been approved for publication. Note that approval does not signify that the contents necessarily reflect the views of the Agency. Mention of trade names, products, or services does not convey official EPA approval, endorsement, or recommendation. NR 38 TC 0 Z9 0 U1 2 U2 2 PU WATER ENVIRONMENT FEDERATION PI ALEXANDRIA PA 601 WYTHE ST, ALEXANDRIA, VA 22314-1994 USA SN 1061-4303 EI 1554-7531 J9 WATER ENVIRON RES JI Water Environ. Res. PD JAN PY 2017 VL 89 IS 1 BP 24 EP 31 DI 10.2175/106143016X14733681696167 PG 8 WC Engineering, Environmental; Environmental Sciences; Limnology; Water Resources SC Engineering; Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA EO0CM UT WOS:000396365900003 PM 28236826 ER PT J AU Gordon, CJ Phillips, PM Ledbetter, A Snow, SJ Schladweiler, MC Johnstone, AFM Kodavanti, UP AF Gordon, C. J. Phillips, P. M. Ledbetter, A. Snow, S. J. Schladweiler, M. C. Johnstone, A. F. M. Kodavanti, U. P. TI Active vs. sedentary lifestyle from weaning to adulthood and susceptibility to ozone in rats SO AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY LA English DT Article DE body composition; ozone; running wheel ID BROWN-NORWAY RATS; BODY-COMPOSITION; FEMALE RATS; PULMONARY SENSITIVITY; POSTNATAL-DEVELOPMENT; GAMMA-TOCOPHEROL; GENETIC STRAIN; MOTOR-ACTIVITY; EXPOSURE; EXERCISE AB The prevalence of a sedentary (SED) life style combined with calorically rich diets has spurred the rise in childhood obesity, which, in turn, translates to adverse health effects in adulthood. Obesity and lack of active (ACT) lifestyle may increase susceptibility to air pollutants. We housed 22-day-old female Long-Evans rats in a cage without (SED) or with a running wheel (ACT). After 10 wk the rats ran 310 +/- 16.3 km. Responses of SED and ACT rats to whole-body O-3 (0, 0.25, 0.5, or 1.0 ppm; 5 h/day for 2 days) was assessed. Glucose tolerance testing (GTT) was performed following the first day of O-3. ACT rats had less body fat and an improved glucose GTT. Ventilatory function (plethysmography) of SED and ACT groups was similarly impaired by O-3. Bronchoalveolar lavage fluid (BALF) was collected after the second O-3 exposure. SED and ACT rats were hyperglycemic following 1.0 ppm O-3. GTT was impaired by O-3 in both groups; however, ACT rats exhibited improved recovery to 0.25 and 1.0 ppm O-3. BALF cell neutrophils and total cells were similarly increased in ACT and SED groups exposed to 1.0 ppm O-3. O-3-induced increase in eosinophils was exacerbated in SED rats. Chronic exercise from postweaning to adulthood improved some of the metabolic and pulmonary responses to O-3 (GTT and eosinophils) but several other parameters were unaffected. The reduction in O-3-induced rise in BALF eosinophils in ACT rats suggests a possible link between a SED lifestyle and incidence of asthma-related symptoms from O-3. C1 [Gordon, C. J.; Phillips, P. M.; Johnstone, A. F. M.] US EPA, Tox Assessment Div, Res Triangle Pk, NC 27711 USA. [Ledbetter, A.; Snow, S. J.; Schladweiler, M. C.; Kodavanti, U. P.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. RP Gordon, CJ (reprint author), US EPA, Res Triangle Pk, NC 27711 USA. EM gordon.christopher@epa.gov OI Snow, Samantha/0000-0003-1812-8582 NR 36 TC 0 Z9 0 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 1040-0605 EI 1522-1504 J9 AM J PHYSIOL-LUNG C JI Am. J. Physiol.-Lung Cell. Mol. Physiol. PD JAN PY 2017 VL 312 IS 1 BP L100 EP L109 DI 10.1152/ajplung.00415.2016 PG 10 WC Physiology; Respiratory System SC Physiology; Respiratory System GA EK2XT UT WOS:000393791100010 PM 27836902 ER PT J AU Karna, RR Luxton, T Bronstein, KE Redmon, JH Scheckel, KG AF Karna, Ranju R. Luxton, Todd Bronstein, Katherine E. Redmon, Jennifer Hoponick Scheckel, Kirk G. TI State of the science review: Potential for beneficial use of waste by-products for in situ remediation of metal-contaminated soil and sediment SO CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY LA English DT Review DE Amendments; metals; remediation; waste by-products ID WATER-TREATMENT RESIDUALS; FLY-ASH AMENDMENT; HEAVY-METALS; AQUEOUS-SOLUTIONS; CHEMICAL IMMOBILIZATION; POLLUTED SOILS; ACIDIC SOIL; INORGANIC AMENDMENTS; ACTIVATED CARBON; BAUXITE RESIDUE AB Metal and metalloid contamination of soil and sediment is a widespread problem both in urban and rural areas throughout the United States (U.S. EPA, 2014). Beneficial use of waste by-products as amendments to remediate metal-contaminated soils and sediments can provide major economic and environmental advantages on both a site-specific and national scale. These waste by-products can also reduce our need to mine virgin materials or produce synthetic materials for amendments. Waste by-products must not be hazardous or pose unacceptable risk to human health and the environment, and should be a suitable replacement for virgin and synthetic materials. This review serves to present the state of science on in situ remediation of metal-contaminated soil and sediment and the potential for beneficial usage of waste by-product materials. Not all unintended consequences can be fully understood or predicted prior to implementing a treatment option, however some realized, and potentially unrealized, benefits and unintended consequences are explored. C1 [Karna, Ranju R.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Karna, Ranju R.; Luxton, Todd; Scheckel, Kirk G.] US EPA, Natl Risk Management Res Lab, 5995 Ctr Hill Ave, Cincinnati, OH 45224 USA. [Bronstein, Katherine E.; Redmon, Jennifer Hoponick] RTI Int, Res Triangle Pk, NC USA. RP Scheckel, KG (reprint author), US EPA, Natl Risk Management Res Lab, 5995 Ctr Hill Ave, Cincinnati, OH 45224 USA. EM Scheckel.kirk@epa.gov NR 203 TC 0 Z9 0 U1 4 U2 4 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1064-3389 EI 1547-6537 J9 CRIT REV ENV SCI TEC JI Crit. Rev. Environ. Sci. Technol. PY 2017 VL 47 IS 2 BP 65 EP 129 DI 10.1080/10643389.2016.1275417 PG 65 WC Environmental Sciences SC Environmental Sciences & Ecology GA EM2VZ UT WOS:000395175200001 ER PT J AU Kalin, L Hantush, MM AF Kalin, Latif Hantush, Mohamed M. TI Special Issue on Advances in Wetland Hydrology and Water Quality Processes Modeling SO JOURNAL OF HYDROLOGIC ENGINEERING LA English DT Editorial Material C1 [Kalin, Latif] Auburn Univ, Sch Forestry & Wildlife Sci, Auburn, AL 36849 USA. [Hantush, Mohamed M.] US EPA, Natl Risk Management Res Lab, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA. RP Kalin, L (reprint author), Auburn Univ, Sch Forestry & Wildlife Sci, Auburn, AL 36849 USA. EM latif@auburn.edu; hantush.mohamed@epa.gov NR 11 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1084-0699 EI 1943-5584 J9 J HYDROL ENG JI J. Hydrol. Eng. PD JAN PY 2017 VL 22 IS 1 SI SI AR D2016001 DI 10.1061/(ASCE)HE.1943-5584.0001483 PG 2 WC Engineering, Civil; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA EJ9DA UT WOS:000393525600001 ER PT J AU Sharifi, A Hantush, MM Kalin, L AF Sharifi, A. Hantush, M. M. Kalin, L. TI Modeling Nitrogen and Carbon Dynamics in Wetland Soils and Water Using Mechanistic Wetland Model SO JOURNAL OF HYDROLOGIC ENGINEERING LA English DT Article DE Wetland modeling; Nitrogen; Carbon; Process based ID POROUS-MEDIA; MOISTURE; RESPIRATION; TEMPERATURE; GROUNDWATER; EVAPORATION; SIMULATION; NUTRIENT; EQUATION AB In this article, extension and application to variably saturated wetland conditions of a process-based wetland model is demonstrated. The new model described in this article is an improved version of an earlier model, which was only capable of capturing nutrient dynamics in continuously ponded wetlands. The upgraded model is capable of simulating nutrient cycling and biogeochemical reactions in both ponded and unsaturated wetland zones. To accomplish this goal, a comprehensive module for tracking water content in wetland soil was implemented in the model, and biogeochemical relationships were added to explain cycling of nitrogen (N) and carbon (C) in variably saturated zones of wetlands. The developed model was applied to a small, restored wetland receiving agricultural runoff, located on Kent Island, Maryland. On average, during the two-year study period, the ponded compartment of the study wetland covered 65% of the total 1.2 ha area. Through mass balance analysis, it was revealed that the mass of nitrogen lost to denitrification at the variably saturated compartment of the study wetland was about three times higher than that of the ponded compartment (32.7 +/- 29.3 kg versus 9.5 +/- 5.5 kg), whereas ammonia volatilization at the variably saturated compartment was a fraction of that of ponded compartment (1.2 +/- 1.9 kg versus 11.3 +/- 11.8 kg). Sensitivity analysis showed that cycling of carbon-related constituents in variably saturated compartment had high sensitivity to temperature and available soil moisture. (C) 2016 American Society of Civil Engineers. C1 [Sharifi, A.] Univ Maryland, 10300 Baltimore Ave,Bldg 007, Beltsville, MD 20705 USA. [Hantush, M. M.] US EPA, Natl Risk Management Res Lab, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA. [Kalin, L.] Auburn Univ, 602 Duncan Dr, Auburn, AL 36849 USA. RP Sharifi, A (reprint author), Univ Maryland, 10300 Baltimore Ave,Bldg 007, Beltsville, MD 20705 USA. EM Sharifi@umd.edu FU U.S. Environmental Protection Agency through its Office of Research and Development under EPA [EP-C-11-006] FX The U.S. Environmental Protection Agency through its Office of Research and Development funded and managed the research described here under EPA Contract # EP-C-11-006. It has not been subjected to Agency review and therefore does not necessarily reflect the views of the Agency, and no official endorsement should be inferred. NR 36 TC 0 Z9 0 U1 3 U2 3 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1084-0699 EI 1943-5584 J9 J HYDROL ENG JI J. Hydrol. Eng. PD JAN PY 2017 VL 22 IS 1 SI SI AR D4016002 DI 10.1061/(ASCE)HE.1943-5584.0001441 PG 18 WC Engineering, Civil; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA EJ9DA UT WOS:000393525600006 ER PT J AU Sharifi, A Kalin, L Hantush, MM Dahlgren, RA O'Geen, AT Maynard, JJ AF Sharifi, A. Kalin, L. Hantush, M. M. Dahlgren, R. A. O'Geen, A. T. Maynard, J. J. TI Capturing Spatial Variability of Biogeochemical Mass Exchanges and Reaction Rates in Wetland Water and Soil through Model Compartmentalization SO JOURNAL OF HYDROLOGIC ENGINEERING LA English DT Article ID STATISTICAL-MODEL; IDENTIFICATION; NITROGEN; CARBON AB A common phenomenon observed in natural and constructed wetlands is short-circuiting of flow and formation of stagnant zones that are only indirectly connected with the incoming water. Biogeochemistry of passive areas is potentially much different than that of active zones. In the research reported in this paper, the spatial resolution of a previously developed wetland nutrient cycling model was improved in order to capture the spatial variability of concentrations and reaction rates regarding nitrogen and carbon cycles throughout active and passive zones of wetlands. The upgraded model allows for several compartments in the horizontal domain, with all neighboring compartments connected through advective and dispersive/diffusive mass transport. The model was applied to data collected from a restored wetland in California that was characterized by the formation of a large stagnant zone at the southern end of the wetland due to close vicinity of the inlet and outlet structures in the northern end. Mass balance analysis revealed that over the course of the research period, about 23.4 +/- 3.9% of the incoming total nitrogen load was removed or retained by the wetland. It was observed that mass of all exchanges (physical and biogeochemical) regarding nitrogen cycling decreased along the activity gradient from active to passive zones. Model results also revealed that anaerobic processes become more significant along the activity gradient towards passive areas. (C) 2015 American Society of Civil Engineers. C1 [Sharifi, A.] Univ Maryland, 10300 Baltimore Ave,Bldg 007, Beltsville, MD 20705 USA. [Kalin, L.] Auburn Univ, 602 Duncan Dr, Auburn, AL 36849 USA. [Hantush, M. M.] US EPA, Natl Risk Management Res Lab, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA. [Dahlgren, R. A.; O'Geen, A. T.] Univ Calif Davis, One Shields Ave, Davis, CA 95616 USA. [O'Geen, A. T.] Univ Calif Davis, Cooperat Extens, One Shields Ave, Davis, CA 95616 USA. [Maynard, J. J.] New Mexico State Univ, Jornada Expt Range, ARS, USDA, POB 30003,MSC 3JER, Las Cruces, NM 88003 USA. RP Sharifi, A (reprint author), Univ Maryland, 10300 Baltimore Ave,Bldg 007, Beltsville, MD 20705 USA. EM amirrezasharifi@gmail.com FU U.S. EPA through its Office of Research and Development [EP-C-11-006]; Auburn University, School of Forestry and Wildlife Sciences FX The U.S. EPA through its Office of Research and Development partially funded and collaborated in the research reported in this paper under Contract EP-C-11-006 with Auburn University, School of Forestry and Wildlife Sciences. It has not been subject to the EPA review and therefore does not necessarily reflect the views of the EPA, and no official endorsement should be inferred. NR 34 TC 2 Z9 2 U1 2 U2 2 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1084-0699 EI 1943-5584 J9 J HYDROL ENG JI J. Hydrol. Eng. PD JAN PY 2017 VL 22 IS 1 SI SI AR D4015001 DI 10.1061/(ASCE)HE.1943-5584.0001196 PG 18 WC Engineering, Civil; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA EJ9DA UT WOS:000393525600002 ER PT J AU Herr, DW AF Herr, David W. TI Commentary on topic: Should all tests of cognitive function Learning, memory, attention - Be eliminated from the required protocols for developmental neurotoxicity testing? SO NEUROTOXICOLOGY AND TERATOLOGY LA English DT Editorial Material DE DNT; Guidelines; Learning; Memory; Cognitive ID TOXICITY; RISK C1 [Herr, David W.] US EPA, Neurotoxicol Branch, Tox Assessment Div, NHEERL,ORD, MD B105-04,109 TW Alexander Dr, Durham, NC 27711 USA. RP Herr, DW (reprint author), US EPA, Neurotoxicol Branch, Tox Assessment Div, NHEERL,ORD, MD B105-04,109 TW Alexander Dr, Durham, NC 27711 USA. EM Herr.david@epa.gov NR 15 TC 0 Z9 0 U1 1 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0892-0362 EI 1872-9738 J9 NEUROTOXICOL TERATOL JI Neurotoxicol. Teratol. PD JAN-FEB PY 2017 VL 59 BP 74 EP 75 DI 10.1016/j.ntt.2016.12.001 PG 2 WC Neurosciences; Toxicology SC Neurosciences & Neurology; Toxicology GA EJ0HV UT WOS:000392890100009 PM 27939643 ER PT J AU Andersen, ME Modak, N Winterrowd, CK Lee, CW Roberts, WL Wendt, JOL Linak, WP AF Andersen, Myrrha E. Modak, Nabanita Winterrowd, Christopher K. Lee, Chun Wai Roberts, William L. Wendt, Jost O. L. Linak, William P. TI Soot, organics, and ultrafine ash from air-and oxy-fired coal combustion SO PROCEEDINGS OF THE COMBUSTION INSTITUTE LA English DT Article DE Oxy-coal combustion; Ultrafine fly ash; Loss on ignition; Elemental carbon; Organic carbon ID PULVERIZED-COAL; FLY-ASH; UNBURNED CARBON; DIESEL EXHAUST; FUEL COMBUSTION; PARTICLES; EMISSIONS; IGNITION; DEVOLATILIZATION; PYROLYSIS AB Pulverized bituminous coal was burned in a 10 W externally heated entrained flow furnace under air-combustion and three oxy-combustion inlet oxygen conditions (28, 32, and 36%). Experiments were designed to produce flames with practically relevant stoichiometric ratios (SR = 1.2-1.4) and constant residence times (2.3 s). Size-classified fly ash samples were collected, and measurements focused on the soot, elemental carbon (EC), and organic carbon (OC) composition of the total and ultrafine (< 0.6 mu m) fly ash. Results indicate that although the total fly ash carbon, as measured by loss on ignition, was always acceptably low (< 2%) with all three oxy-combustion conditions lower than air-combustion, the ultrafine fly ash for both air-fired and oxy-fired combustion conditions consists primarily of carbonaceous material (50-95%). Carbonaceous com-ponents on particles < 0.6 mu m measured by a thermal optical method showed that large fractions (52-93%) consisted of OC rather than EC, as expected. This observation was supported by thermogravimetric analysis indicating that for the air, 28% oxy, and 32% oxy conditions, 14-71% of this material may be OC volatilizing between 100 degrees C and 550 degrees C with the remaining 29-86% being EC/soot. However, for the 36% oxy condition, OC may comprise over 90% of the ultrafine carbon with a much smaller EC/soot contribution. These data were interpreted by considering the effects of oxy-combustion on flame attachment, ignition delay, and soot oxidation of a bituminous coal, and the effects of these processes on OC and EC emissions. Flame aerodynamics and inlet oxidant composition may influence emissions of organic hazardous air pollutants (HAPs) from a bituminous coal. During oxy-coal combustion, judicious control of inlet oxygen concentration and placement may be used to minimize organic HAP and soot emissions. (C) 2016 by The Combustion Institute. Published by Elsevier Inc. C1 [Andersen, Myrrha E.; Roberts, William L.] North Carolina State Univ, Dept Mech & Aerosp Engn, Raleigh, NC 27695 USA. [Andersen, Myrrha E.; Modak, Nabanita] Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37830 USA. [Modak, Nabanita; Lee, Chun Wai; Linak, William P.] US EPA, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. [Winterrowd, Christopher K.] ARCADIS US Inc, Durham, NC 27713 USA. [Winterrowd, Christopher K.] Jacobs Inc, Res Triangle Pk, NC 27711 USA. [Roberts, William L.] King Abdullah Univ Sci & Technol, Dept Mech Engn, Thuwal 239556900, Saudi Arabia. [Wendt, Jost O. L.] Univ Utah, Dept Chem Engn, Salt Lake City, UT 84112 USA. RP Linak, WP (reprint author), US EPA, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. EM linak.bill@epa.gov FU EPA/DOE [DW-89-92298301]; EPA [EP-C-09-027]; Oak Ridge Institute for Science and Education (ORISE); ARCADIS U.S., Inc. FX Portions of this work were sponsored under the EPA/DOE interagency agreement DW-89-92298301 with Oak Ridge Institute for Science and Education (ORISE) and EPA contract EP-C-09-027 with ARCADIS U.S., Inc. The authors are grateful to Daniel Janek, Aaron DeBlois, James Gustafson, Garrett Wiley, Mike Tufts, Bill Preston, Dean Smith, and Bakul Patel for their assistance in the construction and operation of the experimental combustor, and sample collection, and analyses. The research described in this article has been reviewed by the U.S. EPA National Risk Management Research Laboratory and approved for publication. The contents of this article should not be construed to represent Agency policy nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 32 TC 0 Z9 0 U1 5 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1540-7489 EI 1873-2704 J9 P COMBUST INST JI Proc. Combust. Inst. PY 2017 VL 36 IS 3 BP 4029 EP 4037 DI 10.1016/j.proci.2016.08.073 PG 9 WC Thermodynamics; Energy & Fuels; Engineering, Chemical; Engineering, Mechanical SC Thermodynamics; Energy & Fuels; Engineering GA EJ7OT UT WOS:000393412600078 ER PT J AU Huang, HT Barzyk, TM AF Huang, Hongtai Barzyk, Timothy M. TI Connecting the Dots: Linking Environmental Justice Indicators to Daily Dose Model Estimates SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH LA English DT Article DE environmental justice; risk assessment; multiple stressors; dose estimates ID CUMULATIVE RISK-ASSESSMENT; AIR TOXICS EXPOSURES; UNITED-STATES; NONCHEMICAL STRESSORS; SOCIAL VULNERABILITY; SCREENING METHOD; CANCER-RISK; POLLUTION; HEALTH; DISPARITIES AB Many different quantitative techniques have been developed to either assess Environmental Justice (EJ) issues or estimate exposure and dose for risk assessment. However, very few approaches have been applied to link EJ factors to exposure dose estimate and identify potential impacts of EJ factors on dose-related variables. The purpose of this study is to identify quantitative approaches that incorporate conventional risk assessment (RA) dose modeling and cumulative risk assessment (CRA) considerations of disproportionate environmental exposure. We apply the Average Daily Dose (ADD) model, which has been commonly used in RA, to better understand impacts of EJ indicators upon exposure dose estimates and dose-related variables, termed the Environmental-Justice-Average-Daily-Dose (EJ-ADD) approach. On the U.S. nationwide census tract-level, we defined and quantified two EJ indicators (poverty and race/ethnicity) using an EJ scoring method to examine their relation to census tract-level multi-chemical exposure dose estimates. Pollutant doses for each tract were calculated using the ADD model, and EJ scores were assigned to each tract based on poverty-or race-related population percentages. Single-and multiple-chemical ADD values were matched to the tract-level EJ scores to analyze disproportionate dose relationships and contributing EJ factors. We found that when both EJ indicators were examined simultaneously, ADD for all pollutants generally increased with larger EJ scores. To demonstrate the utility of using EJ-ADD on the local scale, we approximated ADD levels of lead via soil/dust ingestion for simulated communities with different EJ-related scenarios. The local-level simulation indicates a substantial difference in exposure-dose levels between wealthy and EJ communities. The application of the EJ-ADD approach can link EJ factors to exposure dose estimate and identify potential EJ impacts on dose-related variables. C1 [Huang, Hongtai] US EPA, ORISE, Natl Exposure Res Lab, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. [Huang, Hongtai; Barzyk, Timothy M.] US EPA, Natl Exposure Res Lab, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM Huang.Hongtai@epa.gov; Barzyk.Timothy@epa.gov FU Postdoctoral Research Program at the (National Exposure Research Laboratory, Research Triangle Park) FX This research was supported in part by an appointment to the Postdoctoral Research Program at the (National Exposure Research Laboratory, Research Triangle Park) administered by the Oak Ridge Institute for Science and Education through Interagency Agreement between the U.S. Department of Energy and the U.S. Environmental Protection Agency. We thank Jane Ellen Simmons for her comments and suggestion. NR 63 TC 0 Z9 0 U1 5 U2 5 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 1660-4601 J9 INT J ENV RES PUB HE JI Int. J. Environ. Res. Public Health PD JAN PY 2017 VL 14 IS 1 AR 24 DI 10.3390/ijerph14010024 PG 15 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA EI6AU UT WOS:000392578200024 ER PT J AU Rossman, PD Boccelli, DL Pressman, JG AF Rossman, Paul D. Boccelli, Dominic L. Pressman, Jonathan G. TI Characterizing Ohio River NOM Variability and Reconstituted-Lyophilized NOM as a Source Surrogate SO JOURNAL AMERICAN WATER WORKS ASSOCIATION LA English DT Article C1 [Pressman, Jonathan G.] US EPA, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM pressman.jonathan@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER WATER WORKS ASSOC PI DENVER PA 6666 W QUINCY AVE, DENVER, CO 80235 USA SN 2164-4535 J9 J AM WATER WORKS ASS JI J. Am. Water Work Assoc. PD JAN PY 2017 VL 109 IS 1 BP 70 EP 70 DI 10.5942/jawwa.2017.109.0008 PG 1 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA EI5VI UT WOS:000392564000011 ER PT J AU Zang, Q Mansouri, K Williams, AJ Judson, RS Allen, DG Casey, WM Kleinstreuer, NC AF Zang, Qingda Mansouri, Kamel Williams, Antony J. Judson, Richard S. Allen, David G. Casey, Warren M. Kleinstreuer, Nicole C. TI In Silico Prediction of Physicochemical Properties of Environmental Chemicals Using Molecular Fingerprints and Machine Learning SO JOURNAL OF CHEMICAL INFORMATION AND MODELING LA English DT Article ID COMPUTATIONAL TOXICOLOGY RESOURCE; AQUEOUS SOLUBILITY; APPLICABILITY DOMAIN; ORGANIC-COMPOUNDS; QSPR MODELS; TOXCAST PROGRAM; BOILING POINTS; LOG-P; PERSPECTIVE; EXPOSURE AB There are little available toxicity data on the vast majority of chemicals in commerce. High-throughput screening (HTS) studies, such as those being carried out by the U.S. Environmental Protection Agency (EPA) ToxCast program in partnership with the federal Tox21 research program, can generate biological data to inform models for predicting potential toxicity. However, physicochemical properties are also needed to model environmental fate and transport, as well as exposure potential. The purpose of the present study was to generate an open-source quantitative structure property relationship (QSPR) workflow to predict a variety of physicochemical properties that would have cross-platform compatibility to integrate into existing cheminformatics workflows. In this effort, decades-old experimental property data sets available within the EPA EPI Suite were reanalyzed using modern cheminfoimatics workflows to develop updated QSPR models capable of supplying computationally efficient, open, and transparent HTS property predictions in support of environmental modeling efforts. Models were built using updated EPI Suite data sets for the prediction of six physicochemical properties: octanol water partition coefficient (logP), water solubility (logS), boiling point (BP), melting point (MP), vapor pressure (logVP), and bioconcentration factor (logBCF). The coefficient of determination (R-2) between the estimated values and experimental data for the six predicted properties ranged from 0.826 (MP) to 0.965 (BP), with model performance for five of the six properties exceeding those from the original EPI Suite models. The newly derived models can be employed for rapid estimation of physicochemical properties within an open-source HTS workflow to inform fate and toxicity prediction models of environmental chemicals. C1 [Zang, Qingda; Allen, David G.] Integrated Lab Syst Inc, Res Triangle Pk, NC 27709 USA. [Mansouri, Kamel; Williams, Antony J.; Judson, Richard S.] US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Casey, Warren M.; Kleinstreuer, Nicole C.] NIEHS, Natl Toxicol Program, Res Triangle Pk, NC 27709 USA. RP Kleinstreuer, NC (reprint author), 530 Davis Dr, Morrisville, NC 27560 USA. EM nicole.kleinstreuer@nih.gov OI Mansouri, Kamel/0000-0002-6426-8036; Kleinstreuer, Nicole/0000-0002-7914-3682 FU National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH) [HHSN273201500010C] FX We would like to express our deep appreciation to Dr. Ann Richard (EPA National Center for Computational Toxicology) and Dr. Shannon Bell (Integrated Laboratory Systems, Inc.) for their constructive suggestions for this manuscript. We also thank Ms. Catherine Sprankle (Integrated Laboratory Systems, Inc.) for editorial review. This project was funded in whole or in part with federal funds from the National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH) under contract HHSN273201500010C to Integrated Laboratory Systems in support of NICEATM. NR 61 TC 0 Z9 0 U1 15 U2 15 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1549-9596 EI 1549-960X J9 J CHEM INF MODEL JI J. Chem Inf. Model. PD JAN PY 2017 VL 57 IS 1 BP 36 EP 49 DI 10.1021/acs.jcim.6b00625 PG 14 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Computer Science, Information Systems; Computer Science, Interdisciplinary Applications SC Pharmacology & Pharmacy; Chemistry; Computer Science GA EI7OK UT WOS:000392687400006 PM 28006899 ER PT J AU Ruskin, KJ Etterson, MA Hodgman, TP Borowske, AC Cohen, JB Elphick, CS Field, CR Kern, RA King, E Kocek, AR Kovach, AI O'Brien, KM Pau, N Shriver, WG Walsh, J Olsen, BJ AF Ruskin, Katharine J. Etterson, Matthew A. Hodgman, Thomas P. Borowske, Alyssa C. Cohen, Jonathan B. Elphick, Chris S. Field, Christopher R. Kern, Rebecca A. King, Erin Kocek, Alison R. Kovach, Adrienne I. O'Brien, Kathleen M. Pau, Nancy Shriver, W. Gregory Walsh, Jennifer Olsen, Brian J. TI Seasonal fecundity is not related to geographic position across a species' global range despite a central peak in abundance SO OECOLOGIA LA English DT Article DE Latitudinal gradients; Fecundity; Species range; Biogeography; Ammodramus caudacutus ID SPARROW AMMODRAMUS-CAUDACUTUS; ANNUAL REPRODUCTIVE SUCCESS; SHARP-TAILED SPARROWS; BIRDS; SELECTION; DENSITY; MODEL; DISTRIBUTIONS; CONSERVATION; UNDERSTAND AB The range of a species is determined by the balance of its demographic rates across space. Population growth rates are widely hypothesized to be greatest at the geographic center of the species range, but indirect empirical support for this pattern using abundance as a proxy has been mixed, and demographic rates are rarely quantified on a large spatial scale. Therefore, the texture of how demographic rates of a species vary over its range remains an open question. We quantified seasonal fecundity of populations spanning the majority of the global range of a single species, the saltmarsh sparrow (Ammodramus caudacutus), which demonstrates a peak of abundance at the geographic center of its range. We used a novel, population projection method to estimate seasonal fecundity inclusive of seasonal and spatial variation in life history traits that contribute to seasonal fecundity. We replicated our study over 3 years, and compared seasonal fecundity to latitude and distance among plots. We observed large-scale patterns in some life history traits that contribute to seasonal fecundity, such as an increase in clutch size with latitude. However, we observed no relationship between latitude and seasonal fecundity. Instead, fecundity varied greatly among plots separated by as little as 1 km. Our results do not support the hypothesis that demographic rates are highest at the geographic and abundance center of a species range, but rather they suggest that local drivers strongly influence saltmarsh sparrow fecundity across their global range. C1 [Ruskin, Katharine J.; Olsen, Brian J.] Univ Maine, Sch Biol & Ecol, Climate Change Inst, 200 Clapp Greenhouse, Orono, ME 04469 USA. [Etterson, Matthew A.] US EPA, Midcontinent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA. [Hodgman, Thomas P.] Maine Dept Inland Fisheries & Wildlife, Bird Grp, 650 State St, Bangor, ME 04401 USA. [Borowske, Alyssa C.; Elphick, Chris S.; Field, Christopher R.] Univ Connecticut, Ctr Conservat & Biodivers, Dept Ecol & Evolutionary Biol, 75 North Eagleville Rd,U-43, Storrs, CT 06269 USA. [Cohen, Jonathan B.; Kocek, Alison R.] SUNY Coll Environm Sci & Forestry, Dept Environm & Forest Biol, 1 Forestry Dr, Syracuse, NY 13210 USA. [Kern, Rebecca A.; Shriver, W. Gregory] Univ Delaware, Dept Entomol & Wildlife Ecol, 250 Townsend Hall, Newark, DE 19716 USA. [Kern, Rebecca A.] US Fish & Wildlife Serv, Edwin B Forsythe NWR, 800 Great Creek Rd, Galloway, NJ 08205 USA. [King, Erin] US Fish & Wildlife Serv, Reg Div Nat Resources 5, Stewart B McKinney NWR, 733 Old Clinton Rd, Westbrook, CT 06498 USA. [Kovach, Adrienne I.; Walsh, Jennifer] Univ New Hampshire, Dept Nat Resources & Environm, 46 Coll Rd, Durham, NH 03824 USA. [O'Brien, Kathleen M.] US Fish & Wildlife Serv, Rachel Carson Natl Wildlife Refuge, 321 Port Rd, Wells, ME 04090 USA. [Pau, Nancy] US Fish & Wildlife Serv, Parker River Natl Wildlife Refuge, 6 Plum Isl Turnpike, Newburyport, MA 01950 USA. EM katharine.ruskin@maine.edu FU Competitive State Wildlife Grant via the United States Fish and Wildlife Service, Federal Aid in Sportfish and Wildlife Restoration to the states of Delaware, Maryland, Connecticut, and Maine [U2-5-R-1]; United States Fish and Wildlife Service; United States Department of Agriculture (National Institute of Food and Agriculture NH McIntire-Stennis Project) [225,575]; New York Department of Environmental Conservation [AM08634]; National Science Foundation [DEB-1340008]; USDA National Institute of Food and Agriculture [ME0-H-6-00492-12]; National Science Foundation; National Park Service Gateway Learning Center Fellowship; University of Maine; University of New Hampshire; University of Connecticut FX This work was primarily funded by a Competitive State Wildlife Grant (U2-5-R-1) via the United States Fish and Wildlife Service, Federal Aid in Sportfish and Wildlife Restoration to the states of Delaware, Maryland, Connecticut, and Maine. We received additional funding from the United States Fish and Wildlife Service (Region 5, Division of Natural Resources, National Wildlife Refuge System), the United States Department of Agriculture (National Institute of Food and Agriculture NH McIntire-Stennis Project 225,575), the New York Department of Environmental Conservation (AM08634), and the National Science Foundation (DEB-1340008). This project was supported by the USDA National Institute of Food and Agriculture, project number #ME0-H-6-00492-12. This is Maine Agricultural and Forest Experiment Station Publication Number 3501. Graduate students were also funded in part by the National Science Foundation, the National Park Service Gateway Learning Center Fellowship, the University of Maine, the University of New Hampshire, and the University of Connecticut. Thank you to our many collaborators, land owners who allowed access to the plots, and to the dozens of field technicians who helped to collect these data. We also thank BJ McGill for his help at various stages of writing this manuscript and MD Correll for the use of her map. Appropriate animal care was ensured by the Institutional Animal Care and Use Committee of the University of Maine under approval A2011-04-02, University of New Hampshire under approvals 100605 and 130604, State University of New York College of Environmental Science and Forestry under approval 120101, University of Connecticut under approval A11-013, and the University of Delaware under approval AUP1157-2015-2. The findings and conclusions of this article are those of the authors and do not necessarily represent the views of the USFWS or any other funding agency. NR 64 TC 1 Z9 1 U1 1 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0029-8549 EI 1432-1939 J9 OECOLOGIA JI Oecologia PD JAN PY 2017 VL 183 IS 1 BP 291 EP 301 DI 10.1007/s00442-016-3745-8 PG 11 WC Ecology SC Environmental Sciences & Ecology GA EI3LD UT WOS:000392391300024 PM 27718065 ER PT J AU Snyder, MN Henderson, WM Glinski, DA Purucker, ST AF Snyder, Marcia N. Henderson, W. Matthew Glinski, Donna A. Purucker, S. Thomas TI Biomarker analysis of American toad (Anaxyrus americanus) and grey tree frog (Hyla versicolor) tadpoles following exposure to atrazine SO AQUATIC TOXICOLOGY LA English DT Article; Proceedings Paper CT Symposium on Behaviour Revised - Contaminant Effects on Aquatic Animal Behaviour at the 25th Annual Meeting of the Society-of-Environmental-Toxicology-and-Chemistry (SETAC)-Europe CY MAY 03-07, 2015 CL Barcelona, SPAIN SP Soc Environm Toxicol & Chem Europe DE Biomarkers; Amphibians; Pesticides; Support vector machine; Metabolites ID XENOPUS-LAEVIS TADPOLES; METABOLIC PATHWAYS; LARVAL DEVELOPMENT; OXIDATIVE STRESS; REAL-TIME; AMPHIBIANS; FISH; PESTICIDES; FRAGMENTATION; METAMORPHOSIS AB The objective of the current study was to use a biomarker-based approach to investigate the influence of atrazine exposure on American toad (Anaxyrus americanus) and grey tree frog (Hyla versicolor) tadpoles. Atrazine is one of the most frequently detected herbicides in environmental matrices throughout the United States. In surface waters, it has been found at concentrations from 0.04-2859 mu g/L and thus presents a likely exposure scenario for non-target species such as amphibians. Studies have examined the effect of atrazine on the metamorphic parameters of amphibians, however, the data are often contradictory. Gosner stage 22-24 tadpoles were exposed to 0 (control), 10, 50, 250 or 1250 mu g/L of atrazine for 48 h. Endogenous polar metabolites were extracted and analyzed using gas chromatography coupled with mass spectrometry. Statistical analyses of the acquired spectra with machine learning classification models demonstrated identifiable changes in the metabolomic profiles between exposed and control tadpoles. Support vector machine models with recursive feature elimination created a more efficient, non-parametric data analysis and increased interpretability of metabolomic profiles. Biochemical fluxes observed in the exposed groups of both A. americanus and H. versicolor displayed perturbations in a number of classes of biological macromolecules including fatty acids, amino acids, purine nucleosides, pyrimidines, and mono-and di-saccharides. Metabolomic pathway analyses are consistent with findings of other studies demonstrating disruption of amino acid and energy metabolism from atrazine exposure to non-target species. (C) 2016 Published by Elsevier B.V. C1 [Snyder, Marcia N.; Glinski, Donna A.] US EPA, Via Oak Ridge Inst Sci & Educ, Athens, GA 30605 USA. [Snyder, Marcia N.] US EPA, Off Res & Dev, Natl Hlth & Ecol Effects Lab, 200 SW 35th St, Corvallis, OR 97333 USA. [Purucker, S. Thomas] US EPA, Off Res & Dev, Natl Exposure Res Lab, 960 Coll Stn Rd, Athens, GA 30605 USA. RP Snyder, MN (reprint author), US EPA, Off Res & Dev, Natl Hlth & Ecol Effects Lab, 200 SW 35th St, Corvallis, OR 97333 USA. EM snyder.marcia@epa.gov FU Post-doctoral Research Program at the USEPA Ecosystems Research Division, Athens, GA; United States Department of Energy [DW8992298301]; United States Environmental Protection Agency [DW8992298301] FX Thanks to John Davis, Jennifer Olker, Colleen Rossmeisl and Fran Rauschenberg for manuscript review and edits. This IACUC protocol (A2012 05-018-Y1-A0) received approval from the University of Georgia Institutional Animal Care and Use Committee. This research was supported in part by an appointment to the Post-doctoral Research Program at the USEPA Ecosystems Research Division, Athens, GA, administered by the Oak Ridge Institute for Science and Education through Interagency Agreement No. DW8992298301 between the United States Department of Energy and the United States Environmental Protection Agency. This paper has been reviewed in accordance with Agency policy and approved for publication. The views expressed in this article are those of the authors and do not necessarily represent the views or policies of the USEPA. NR 56 TC 0 Z9 0 U1 11 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-445X EI 1879-1514 J9 AQUAT TOXICOL JI Aquat. Toxicol. PD JAN PY 2017 VL 182 BP 184 EP 193 DI 10.1016/j.aquatox.2016.11.018 PG 10 WC Marine & Freshwater Biology; Toxicology SC Marine & Freshwater Biology; Toxicology GA EI2XP UT WOS:000392353300018 PM 27912165 ER PT J AU An, G Fitzpatrick, BG Christley, S Federico, P Kanarek, A Neilan, RM Oremland, M Salinas, R Laubenbacher, R Lenhart, S AF An, G. Fitzpatrick, B. G. Christley, S. Federico, P. Kanarek, A. Neilan, R. Miller Oremland, M. Salinas, R. Laubenbacher, R. Lenhart, S. TI Optimization and Control of Agent-Based Models in Biology: A Perspective SO BULLETIN OF MATHEMATICAL BIOLOGY LA English DT Article DE Agent-based modeling; Systems theory; Optimization; Optimal control ID CHRONIC MYELOGENOUS LEUKEMIA; MOUNTAINS NATIONAL-PARK; COLLEGE DRINKING; FERAL HOGS; EQUATIONS; DYNAMICS; SYSTEMS AB Agent-based models (ABMs) have become an increasingly important mode of inquiry for the life sciences. They are particularly valuable for systems that are not understood well enough to build an equation-based model. These advantages, however, are counterbalanced by the difficulty of analyzing and using ABMs, due to the lack of the type of mathematical tools available for more traditional models, which leaves simulation as the primary approach. As models become large, simulation becomes challenging. This paper proposes a novel approach to two mathematical aspects of ABMs, optimization and control, and it presents a few first steps outlining how one might carry out this approach. Rather than viewing the ABM as a model, it is to be viewed as a surrogate for the actual system. For a given optimization or control problem (which may change over time), the surrogate system is modeled instead, using data from the ABM and a modeling framework for which ready-made mathematical tools exist, such as differential equations, or for which control strategies can explored more easily. Once the optimization problem is solved for the model of the surrogate, it is then lifted to the surrogate and tested. The final step is to lift the optimization solution from the surrogate system to the actual system. This program is illustrated with published work, using two relatively simple ABMs as a demonstration, Sugarscape and a consumer-resource ABM. Specific techniques discussed include dimension reduction and approximation of an ABM by difference equations as well systems of PDEs, related to certain specific control objectives. This demonstration illustrates the very challenging mathematical problems that need to be solved before this approach can be realistically applied to complex and large ABMs, current and future. The paper outlines a research program to address them. C1 [An, G.] Univ Chicago, Dept Surg, 5841 S Maryland Ave, Chicago, IL 60637 USA. [Fitzpatrick, B. G.] Loyola Marymount Univ, Dept Math, Los Angeles, CA 90045 USA. [Fitzpatrick, B. G.] Tempest Technol, Los Angeles, CA 90045 USA. [Christley, S.] Univ Texas Southwestern Med Ctr Dallas, Dept Clin Sci, Dallas, TX 75390 USA. [Federico, P.] Capital Univ, Dept Math Comp Sci & Phys, Columbus, OH USA. [Kanarek, A.] US EPA, Washington, DC 20460 USA. [Neilan, R. Miller] Duquesne Univ, Dept Math & Comp Sci, Pittsburgh, PA 15219 USA. [Oremland, M.] Ohio State Univ, Math Biosci Inst, Columbus, OH 43210 USA. [Salinas, R.] Appalachian State Univ, Dept Math Sci, Boone, NC 28608 USA. [Laubenbacher, R.] UConn Hlth, Ctr Quantitat Med, Farmington, CT USA. [Laubenbacher, R.] Jackson Lab Genom Med, Farmington, CT USA. [Lenhart, S.] Univ Tennessee, Dept Math, Knoxville, TN 37996 USA. [Lenhart, S.] Univ Tennessee, NIMBioS, Knoxville, TN 37996 USA. RP Fitzpatrick, BG (reprint author), Loyola Marymount Univ, Dept Math, Los Angeles, CA 90045 USA.; Fitzpatrick, BG (reprint author), Tempest Technol, Los Angeles, CA 90045 USA. EM bfitzpatrick@lmu.edu OI An, Gary/0000-0003-4549-9004 FU NIMBioS - National Science Foundation; U.S. Department of Homeland Security; U.S. Department of Agriculture, through NSF [EF-0832858NSF]; NIMBioS [DBI-1300426]; Air Force Office of Scientific Research [FA9550-09-1-0524, FA9550-10-1-0499]; U.S. DoD [N911NF0910538]; NSF [DMS-1062878, DMS-0931642]; National Institutes of Health [R01-GM-115839, P30-DK-42086] FX This Project grew out of a NIMBioS (National Institute for Mathematical and Biological Synthesis) workshop in December 2009, followed in 2011 by ongoing work of an interdisciplinary NIMBioS working group (15 members) "Agent-based modeling of biological systems: pathways to control and optimization." The workshop and working group were funded by NIMBioS, sponsored by the National Science Foundation, the U.S. Department of Homeland Security and the U.S. Department of Agriculture, through NSF Award EF-0832858NSF. The work of Lenhart and Fitzpatrick is also partially supported by NIMBioS Award DBI-1300426. Fitzpatrick has also been supported in part by the Air Force Office of Scientific Research grants FA9550-09-1-0524 and FA9550-10-1-0499. The work of Oremland and Laubenbacher has been supported by Grants N911NF0910538 (U.S. DoD) and DMS-1062878 (NSF), and Oremland was partially supported by NSF grant DMS-0931642 to the Mathematical Biosciences Institute. An's work was partially supported by National Institutes of Health Grants R01-GM-115839 and P30-DK-42086. NR 36 TC 0 Z9 0 U1 2 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0092-8240 EI 1522-9602 J9 B MATH BIOL JI Bull. Math. Biol. PD JAN PY 2017 VL 79 IS 1 BP 63 EP 87 DI 10.1007/s11538-016-0225-6 PG 25 WC Biology; Mathematical & Computational Biology SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational Biology GA EI0WH UT WOS:000392195500004 PM 27826879 ER PT J AU Houck, KA Judson, RS Knudsen, TB Martin, MT Richard, AM Crofton, KM Simeonov, A Paules, RS Bucher, JR Thomas, RS AF Houck, Keith A. Judson, Richard S. Knudsen, Thomas B. Martin, Matthew T. Richard, Ann M. Crofton, Kevin M. Simeonov, Anton Paules, Richard S. Bucher, John R. Thomas, Russell S. TI Comment on "On the Utility of ToxCast (TM) and ToxPi as Methods for Identifying New Obesogens" SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Letter ID ESTROGEN-RECEPTOR; PPAR-GAMMA; CHEMICALS; ASSAYS; PROGRAM; MODEL C1 [Houck, Keith A.; Judson, Richard S.; Knudsen, Thomas B.; Martin, Matthew T.; Richard, Ann M.; Crofton, Kevin M.; Thomas, Russell S.] US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27705 USA. [Simeonov, Anton] NIH, Natl Ctr Advancing Translat Sci, US Dept HHS, Bldg 10, Bethesda, MD 20892 USA. [Paules, Richard S.; Bucher, John R.] NIEHS, Natl Toxicol Program, NIH, US Dept HHS, POB 12233, Res Triangle Pk, NC 27709 USA. RP Thomas, RS (reprint author), US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27705 USA. EM thomas.russell@epa.gov NR 16 TC 0 Z9 0 U1 4 U2 4 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD JAN PY 2017 VL 125 IS 1 BP A8 EP A11 DI 10.1289/EHP881 PG 4 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA EI0WD UT WOS:000392195000028 PM 28055944 ER PT J AU West, JM Courtney, CA Hamilton, AT Parker, BA Julius, SH Hoffman, J Koltes, KH MacGowan, P AF West, Jordan M. Courtney, Catherine A. Hamilton, Anna T. Parker, Britt A. Julius, Susan H. Hoffman, Jennie Koltes, Karen H. MacGowan, Petra TI Climate-Smart Design for Ecosystem Management: A Test Application for Coral Reefs SO ENVIRONMENTAL MANAGEMENT LA English DT Article DE Climate change; Vulnerability; Adaptation planning; Natural resource management; Coral reefs; Decision making ID POPULATION CONNECTIVITY; NUTRIENT ENRICHMENT; OCEAN ACIDIFICATION; CHANGE IMPACTS; RESILIENCE; CONSERVATION; SYSTEMS; RESPONSES; ADAPTATION; TOLERANCE AB The interactive and cumulative impacts of climate change on natural resources such as coral reefs present numerous challenges for conservation planning and management. Climate change adaptation is complex due to climate-stressor interactions across multiple spatial and temporal scales. This leaves decision makers worldwide faced with local, regional, and global-scale threats to ecosystem processes and services, occurring over time frames that require both near-term and long-term planning. Thus there is a need for structured approaches to adaptation planning that integrate existing methods for vulnerability assessment with design and evaluation of effective adaptation responses. The Corals and Climate Adaptation Planning project of the U.S. Coral Reef Task Force seeks to develop guidance for improving coral reef management through tailored application of a climate-smart approach. This approach is based on principles from a recently-published guide which provides a framework for adopting forward-looking goals, based on assessing vulnerabilities to climate change and applying a structured process to design effective adaptation strategies. Work presented in this paper includes: (1) examination of the climate-smart management cycle as it relates to coral reefs; (2) a compilation of adaptation strategies for coral reefs drawn from a comprehensive review of the literature; (3) in-depth demonstration of climate-smart design for place-based crafting of robust adaptation actions; and (4) feedback from stakeholders on the perceived usefulness of the approach. We conclude with a discussion of lessons-learned on integrating climate-smart design into real-world management planning processes and a call from stakeholders for an "adaptation design tool" that is now under development. C1 [West, Jordan M.; Julius, Susan H.] US EPA, Off Res & Dev, 1200 Penn Ave NW,8601P, Washington, DC 20460 USA. [Courtney, Catherine A.] Tetra Tech Inc, 737 Bishop St,Suite 2340, Honolulu, HI 96813 USA. [Hamilton, Anna T.] Tetra Tech Inc, Ctr Ecol Sci, 502 W Cordova Rd,Suite C, Santa Fe, NM 87505 USA. [Parker, Britt A.] Baldwin Grp Inc, NOAA Coral Reef Conservat Program, SSMC4,N-OCM6,Rm 10329,1305 East West Hwy, Silver Spring, MD 20910 USA. [Hoffman, Jennie] 4755 Northeast Lambs Lane, Poulsbo, WA 98370 USA. [Koltes, Karen H.] US Dept Interior, Off Insular Affairs, MS 2429,1849 C St NW, Washington, DC 20240 USA. [MacGowan, Petra] Nature Conservancy, 74 Wall St, Seattle, WA 98121 USA. RP West, JM (reprint author), US EPA, Off Res & Dev, 1200 Penn Ave NW,8601P, Washington, DC 20460 USA. EM west.jordan@epa.gov FU U.S. Environmental Protection Agency [EP-C-12-060] FX This research was funded by U.S. Environmental Protection Agency Contract EP-C-12-060, with travel and workshop contributions from the National Oceanic and Atmospheric Administration's Coral Reef Conservation Program and the Department of the Interior's Office of Insular Affairs. We gratefully acknowledge the constructive feedback offered on an earlier draft by P. Bradley, H. Slay, and R. Coffey. Special thanks to E. Conklin, M. Eakin, and R. Kosaki for expert technical advice early in the project, and to W. Wiltse, H. Slay, T. Callender, E. Anders, T. Leberer, and R. Parsons for key contributions to workshop planning and participation. The views expressed in this article are those of the authors and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency, National Oceanic and Atmospheric Administration, or Department of the Interior. NR 101 TC 0 Z9 0 U1 30 U2 30 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0364-152X EI 1432-1009 J9 ENVIRON MANAGE JI Environ. Manage. PD JAN PY 2017 VL 59 IS 1 BP 102 EP 117 DI 10.1007/s00267-016-0774-3 PG 16 WC Environmental Sciences SC Environmental Sciences & Ecology GA EH8ZQ UT WOS:000392061800009 PM 27734086 ER PT J AU Miller, LR Marks, C Becker, JB Hurn, PD Chen, WJ Woodruff, T McCarthy, MM Sohrabji, F Schiebinger, L Wetherington, CL Makris, S Arnold, AP Einstein, G Miller, VM Sandberg, K Maier, S Cornelison, TL Clayton, JA AF Miller, Leah R. Marks, Cheryl Becker, Jill B. Hurn, Patricia D. Chen, Wei-Jung Woodruff, Teresa McCarthy, Margaret M. Sohrabji, Farida Schiebinger, Londa Wetherington, Cora Lee Makris, Susan Arnold, Arthur P. Einstein, Gillian Miller, Virginia M. Sandberg, Kathryn Maier, Susan Cornelison, Terri L. Clayton, Janine A. TI Considering sex as a biological variable in preclinical research SO FASEB JOURNAL LA English DT Review DE gender; methods; sex influences; sex differences ID MOUSE MODELS; BRAIN; BEHAVIOR; DISEASE; NUMBER; GENES AB In June 2015, the National Institutes of Health (NIH) released a Guide notice (NOT-OD-15-102) that highlighted the expectation of the NIH that the possible role of sex as a biologic variable be factored into research design, analyses, and reporting of vertebrate animal and human studies. Anticipating these guidelines, the NIH Office of Research on Women's Health, in October 2014, convened key stakeholders to discuss methods and techniques for integrating sex as a biologic variable in preclinical research. The workshop focused on practical methods, experimental design, and approaches to statistical analyses in the use of both male and female animals, cells, and tissues in preclinical research. Workshop participants also considered gender as a modifier of biology. This article builds on the workshop and is meant as a guide to preclinical investigators as they consider methods and techniques for inclusion of both sexes in preclinical research and is not intended to prescribe exhaustive/specific approaches for compliance with the new NIH policy.-Miller, L.R., Marks, C., Becker, J. B., Hurn, P. D., Chen, W.-J., Woodruff, T., McCarthy, M. M., Sohrabji, F., Schiebinger, L., Wetherington, C. L., Makris, S., Arnold, A. P., Einstein, G., Miller, V. M., Sandberg, K., Maier, S., Cornelison, T. L., Clayton, J. A. Considering sex as a biological variable in preclinical research. C1 [Miller, Leah R.; Maier, Susan; Cornelison, Terri L.; Clayton, Janine A.] NCI, Off Res Womens Hlth, Bethesda, MD 20892 USA. [Marks, Cheryl] NCI, Div Canc Biol, Bethesda, MD 20892 USA. [Wetherington, Cora Lee] NIDA, NIH, Bethesda, MD 20892 USA. [Becker, Jill B.] Univ Michigan, Mol & Behav Neurosci Inst, Ann Arbor, MI 48109 USA. [Hurn, Patricia D.] Univ Michigan, Sch Nursing, Ann Arbor, MI 48109 USA. [Chen, Wei-Jung; Sohrabji, Farida] Texas A&M Hlth Sci Ctr, Dept Neurosci & Expt Therapeut, Bryan, TX USA. [Woodruff, Teresa] Northwestern Univ, Womens Hlth Res Inst, Chicago, IL 60611 USA. [McCarthy, Margaret M.] Univ Maryland, Dept Pharmacol, Baltimore, MD 21201 USA. [Schiebinger, Londa] Stanford Univ, Hist Sci, Stanford, CA 94305 USA. [Makris, Susan] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Washington, DC 20460 USA. [Arnold, Arthur P.] Univ Calif Los Angeles, Dept Integrat Biol & Physiol, Los Angeles, CA USA. [Arnold, Arthur P.] Univ Calif Los Angeles, Brain Res Inst, Neuroendocrinol Lab, Los Angeles, CA 90024 USA. [Einstein, Gillian] Univ Toronto, Dept Psychol, Toronto, ON, Canada. [Einstein, Gillian] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada. [Einstein, Gillian] Womens Coll Res Inst, Toronto, ON, Canada. [Miller, Virginia M.] Mayo Clin, Dept Surg & Physiol, Rochester, MN USA. [Miller, Virginia M.] Mayo Clin, Dept Biomed Engn, Rochester, MN USA. [Sandberg, Kathryn] Georgetown Univ, Med Ctr, Dept Med, Washington, DC 20007 USA. [Sandberg, Kathryn] Georgetown Univ, Med Ctr, Ctr Study Sex Differences Hlth Aging & Dis, Washington, DC 20007 USA. RP Miller, LR (reprint author), NIH, Off Res Womens Hlth, 6707 Democracy Blvd,Suite 400, Bethesda, MD 20892 USA. EM leah.miller@nih.gov FU NHLBI NIH HHS [R01 HL119380]; NIA NIH HHS [P50 AG044170] NR 22 TC 1 Z9 1 U1 3 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD JAN PY 2017 VL 31 IS 1 BP 29 EP 34 DI 10.1096/fj.201600781R PG 6 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA EI0PW UT WOS:000392177600006 PM 27682203 ER PT J AU Bruins, RJF Canfield, TJ Duke, C Kapustka, L Nahlik, AM Schafer, RB AF Bruins, Randall J. F. Canfield, Timothy J. Duke, Clifford Kapustka, Larry Nahlik, Amanda M. Schaefer, Ralf B. TI Using Ecological Production Functions to Link Ecological Processes to Ecosystem Services SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Article DE Ecological model; Decision making; Stressors; Final ecosystem services; Pesticides ID DECISION-MAKING; RISK-ASSESSMENT; CHEMICAL STRESSORS; MODELS; LANDSCAPE; BIODIVERSITY; RESTORATION; MANAGEMENT; PROTOCOL; FIELD AB Ecological production functions (EPFs) link ecosystems, stressors, and management actions to ecosystem services (ES) production. Although EPFs are acknowledged as being essential to improve environmental management, their use in ecological risk assessment has received relatively little attention. Ecological production functions may be defined as usable expressions (i. e., models) of the processes by which ecosystems produce ES, often including external influences on those processes. We identify key attributes of EPFs and discuss both actual and idealized examples of their use to inform decision making. Whenever possible, EPFs should estimate final, rather than intermediate, ES. Although various types of EPFs have been developed, we suggest that EPFs are more useful for decision making if they quantify ES outcomes, respond to ecosystem condition, respond to stressor levels or management scenarios, reflect ecological complexity, rely on data with broad coverage, have performed well previously, are practical to use, and are open and transparent. In an example using pesticides, we illustrate how EPFs with these attributes could enable the inclusion of ES in ecological risk assessment. The biggest challenges to ES inclusion are limited data sets that are easily adapted for use in modeling EPFs and generally poor understanding of linkages among ecological components and the processes that ultimately deliver the ES. We conclude by advocating for the incorporation into EPFs of added ecological complexity and greater ability to represent the trade-offs among ES. Integr Environ Assess Manag 2017; 13: 52-61. (C) 2016 SETAC. C1 [Bruins, Randall J. F.] US EPA, Natl Exposure Res Lab, Ecol Exposure Res Div, Cincinnati, OH 45268 USA. [Canfield, Timothy J.] US EPA, Natl Risk Management Res Lab, Ground Water & Ecosyst Restorat Div, Ada, OK USA. [Duke, Clifford] Ecol Soc Amer, Washington, DC USA. [Kapustka, Larry] LK Consultancy, Turner Valley, AB, Canada. [Nahlik, Amanda M.] Kenyon Coll, Dept Biol, Gambier, OH 43022 USA. [Nahlik, Amanda M.] US EPA, Western Ecol Div, Corvallis, OR USA. [Schaefer, Ralf B.] Univ Koblenz Landau, Inst Environm Sci, Quantitat Landscape Ecol, Landau, Germany. RP Bruins, RJF (reprint author), US EPA, Natl Exposure Res Lab, Ecol Exposure Res Div, Cincinnati, OH 45268 USA. EM bruins.randy@epa.gov NR 86 TC 4 Z9 4 U1 19 U2 19 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD JAN PY 2017 VL 13 IS 1 BP 52 EP 61 DI 10.1002/ieam.1842 PG 10 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA EH9FW UT WOS:000392078100009 PM 27541951 ER PT J AU Munns, WR Poulsen, V Gala, WR Marshall, SJ Rea, AW Sorensen, MT von Stackelbergzz, K AF Munns, Wayne R., Jr. Poulsen, Veronique Gala, William R. Marshall, Stuart J. Rea, Anne W. Sorensen, Mary T. von Stackelbergzz, Katherine TI Ecosystem Services in Risk Assessment and Management SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Article DE Ecosystem services; Risk assessment; Risk management; Decision making; Human health and well-being ID ECOLOGICAL RISK; FRAMEWORK; VALUATION; SITES AB The ecosystem services (ES) concept holds much promise for environmental decision making. Even so, the concept has yet to gain full traction in the decisions and policies of environmental agencies in the United States, Europe, and elsewhere. In this paper we examine the opportunities for and implications of including ES in risk assessments and the risk management decisions that they inform. We assert that use of ES will: 1) lead to more comprehensive environmental protection; 2) help to articulate the benefits of environmental decisions, policies, and actions; 3) better inform the derivation of environmental quality standards; 4) enable integration of human health and ecological risk assessment; and 5) facilitate horizontal integration of policies, regulations, and programs. We provide the technical basis and supporting rationale for each assertion, relying on examples taken from experiences in the United States and European Union. Specific recommendations are offered for use of ES in risk assessment and risk management, and issues and challenges to advancing use of ES are described together with some of the science needed to improve the value of the ES concept to environmental protection. Integr Environ Assess Manag 2017; 13: 62-73. (C) 2016 SETAC. C1 [Munns, Wayne R., Jr.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Narragansett, RI 02882 USA. [Poulsen, Veronique] French Agcy Food Environm & Occupat Hlth & Safety, Maisons Alfort, France. [Gala, William R.] Chevron Energy Technol Co, San Ramon, CA USA. [Marshall, Stuart J.] Unilever Colworth, Bedford, England. [Rea, Anne W.] US EPA, Off Res & Dev, Safe & Sustainable Water Resources Res Program, Res Triangle Pk, NC 27711 USA. [Sorensen, Mary T.] Ramboll Environ, Atlanta, GA USA. [von Stackelbergzz, Katherine] NEK Associates, Allston, MA USA. RP Munns, WR (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Narragansett, RI 02882 USA. EM munns.wayne@epa.gov FU Chevron Energy Technology Company; Dow Agrosciences; Ramboll Environ US; European Chemical Industry Council; Exponent; ExxonMobil Biomedical Sciences; Rio Tinto; Syngenta; Unilever; US Geological Survey FX We gratefully acknowledge the SETAC staff, in particular Greg Schiefer and Nikki Mayo, who provided support to the steering committee and workshop participants before, during, and after the workshop. We appreciate the funding support from the following groups that made the workshop possible: Chevron Energy Technology Company, Dow Agrosciences, Ramboll Environ US, European Chemical Industry Council, Exponent, ExxonMobil Biomedical Sciences, Rio Tinto, Syngenta, Unilever, and the US Geological Survey. Fruitful discussions of several ideas communicated in this study were held with participants in the joint SETAC-ESA Workshop. J Nicolette, invited but who could not attend the workshop, graciously provided additional thoughts that influenced this communication. DForrow provided input to Assertion 5. Constructive reviews were provided by all workshop attendees, by K Mulvaney, N Merrill, and G Cicchetti, and by 2 anonymous reviewers. This is ORD Tracking Number ORD-010994. NR 70 TC 4 Z9 4 U1 13 U2 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD JAN PY 2017 VL 13 IS 1 BP 62 EP 73 DI 10.1002/ieam.1835 PG 12 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA EH9FW UT WOS:000392078100010 PM 27464004 ER PT J AU Leonard, JA Cope, WG Hammer, EJ Barnhart, MC Bringolf, RB AF Leonard, Jeremy A. Cope, W. Gregory Hammer, Edward J. Barnhart, M. Christopher Bringolf, Robert B. TI Extending the toxicity-testing paradigm for freshwater mussels: Assessing chronic reproductive effects of the synthetic estrogen 17 alpha-ethinylestradiol on the unionid mussel Elliptio complanata SO COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY LA English DT Article DE carbohydrate; Elliptio complanata; ethinylestradiol; glochidia; lipid; protein; Unionid; vitellogenin ID 17 ALPHA-ETHINYLESTRADIOL; CLAM TAPES-PHILIPPINARUM; ALKALI-LABILE PHOSPHATE; ZEBRAFISH DANIO-RERIO; ENDOCRINE DISRUPTION; BIOCHEMICAL-COMPOSITION; MYTILUS-EDULIS; WASTE-WATER; LAMPSILIS-SILIQUOIDEA; DREISSENA-POLYMORPHA AB Surface water concentrations of the synthetic estrogen 17 alpha-ethinylestradiol (EE2) as low as 1 ng/L can cause adverse reproductive effects in fish under acute and chronic exposure conditions, whereas higher concentrations (> 5 ng/L) in acute studies are necessary to elicit adverse effects in freshwater mussels. Prolonged chronic exposures of freshwater mussels to EE2 remain un-evaluated. An extended duration testing paradigm was used to examine reproductive and biochemical (carbohydrate, lipid, protein) effects of EE2 on the unionid mussel, Elliptio complanata, throughout its reproductive cycle. Mussels were exposed to a control and EE2 concentrations (5 and 50 ng/L) in six discrete and sequential 28 d tests, and in one discrete and simultaneous 180 d test, from February through August. Foot protrusion and siphoning behavior were recorded daily, along with conglutinate releases and larval (glochidia) mortality. Gonad, hemolymph, and gonad fluid samples were taken for biochemical and vitellogenin-like protein (Vtg) analysis post-exposure. Female mussels released eggs and conglutinates during the months of April to June, indicating sexual maturation during this time. Conglutinates released in the 5 ng/L treatment in 28 d exposures contained fewer glochidia and more eggs, and increased concentrations of Vtg in hemolymph were observed from April to August in the 5 ng/L treatment during the 180 d exposure. Results indicate that the 180 d test approach, concurrent with the sequence of 28 d tests, enabled a more robust evaluation of mussel behavior and physiology than would have been possible with a single short-term (28 d) test. (C) 2016 Elsevier Inc. All rights reserved. C1 [Leonard, Jeremy A.; Cope, W. Gregory] North Carolina State Univ, Dept Appl Ecol, Box 7617, Raleigh, NC 27695 USA. [Hammer, Edward J.] US EPA, 77 West Jackson Blvd, Chicago, IL 60604 USA. [Barnhart, M. Christopher] Missouri State Univ, Dept Biol, 901 South Ave, Springfield, MO 65897 USA. [Bringolf, Robert B.] Univ Georgia, Warnell Sch Forestry & Nat Resources, 180 East Green St, Athens, GA 30602 USA. RP Leonard, JA (reprint author), US EPA, 109 TW Alexander Dr,Mail Code E205-1, Res Triangle Pk, NC 27709 USA. EM leonard.jeremy@epa.gov FU U.S. Environmental Protection Agency Region 5 Great Lakes Restoration Initiative Program from U.S. Geological Survey [178] FX Funding for this research was provided by the U.S. Environmental Protection Agency Region 5 Great Lakes Restoration Initiative Program through Work Order no. 178 from the U.S. Geological Survey. We thank Charles Delos, Linda Hoist, Lisa Huff, Dave Mount, Charles Stephan, and Brian Thompson of the U.S. EPA for their valuable insight and assistance on project need and experimental design. We also thank Dr. Tom Augspurger of the U.S. Fish and Wildlife Service (U.S. FWS) for his review, comments, and suggestions. The opinions and conclusions expressed in this article are solely the views of the author(s) and do not necessarily reflect those of the U.S. EPA or the U.S. FWS. Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U.S. Government. NR 70 TC 1 Z9 1 U1 6 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1532-0456 EI 1878-1659 J9 COMP BIOCHEM PHYS C JI Comp. Biochem. Physiol. C-Toxicol. Pharmacol. PD JAN PY 2017 VL 191 BP 14 EP 25 DI 10.1016/j.cbpc.2016.09.002 PG 12 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Toxicology; Zoology SC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Toxicology; Zoology GA EH3CZ UT WOS:000391648000003 PM 27612666 ER PT J AU Sarofim, MC Waldhoff, ST Anenberg, SC AF Sarofim, Marcus C. Waldhoff, Stephanie T. Anenberg, Susan C. TI Valuing the Ozone-Related Health Benefits of Methane Emission Controls SO ENVIRONMENTAL & RESOURCE ECONOMICS LA English DT Article DE Methane; Ozone; Mortality; Air pollution; SCC ID TERM CLIMATE-CHANGE; HUMAN MORTALITY; GLOBAL BURDEN; POLLUTION AB Methane is a greenhouse gas that oxidizes to form ground-level ozone, itself a greenhouse gas and a health-harmful air pollutant. Reducing methane emissions will both slow anthropogenic climate change and reduce ozone-related mortality. We estimate the benefits of reducing methane emissions anywhere in the world for ozone-related premature mortality globally and for eight geographic regions. Our methods are consistent with those used by the US Government to estimate the social cost of carbon (SCC). We find that the global short- and long-term premature mortality benefits due to reduced ozone production from methane mitigation are (2011) $790 and $1775 per tonne methane, respectively. These correspond to approximately 70 and 150 % of the valuation of methane's global climate impacts using the SCC after extrapolating from carbon dioxide to methane using global warming potential estimates. Results for monetized benefits are sensitive to a number of factors, particularly the choice of elasticity to income growth used when calculating the value of a statistical life. The benefits increase for emission years further in the future. Regionally, most of the global mortality benefits accrue in Asia, but 10 % accrue in the United States. This methodology can be used to assess the benefits of methane emission reductions anywhere in the world, including those achieved by national and multinational policies. C1 [Sarofim, Marcus C.] US EPA, 6207A,1200 Penn Ave NW, Washington, DC 20460 USA. [Waldhoff, Stephanie T.] Pacific Northwest Natl Lab, Joint Global Change Res Inst, College Pk, MD USA. [Anenberg, Susan C.] Environm Hlth Analyt LLC, Washington, DC USA. RP Sarofim, MC (reprint author), US EPA, 6207A,1200 Penn Ave NW, Washington, DC 20460 USA. EM Sarofim.marcus@epa.gov; Stephanie.waldhoff@pnnl.gov; susan.anenberg@airhealthanalytics.com FU U.S. Environmental Protection Agency FX The authors would like to thank Neal Fann, Amy Lamson, Bryan Hubbell, Jason West, and Steve Smith for reviews and comments on drafts of this paper. Stephanie Waldhoff gratefully acknowledges the U.S. Environmental Protection Agency for support of this work. Susan Anenberg performed the work on this paper while employed by the U.S. Environmental Protection Agency. The views expressed in this paper are those of the authors and do not reflect those of the U.S. Environmental Protection Agency, Pacific Northwest National Laboratory, nor the U.S. Department of Energy. NR 32 TC 1 Z9 1 U1 6 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0924-6460 EI 1573-1502 J9 ENVIRON RESOUR ECON JI Environ. Resour. Econ. PD JAN PY 2017 VL 66 IS 1 BP 45 EP 63 DI 10.1007/s10640-015-9937-6 PG 19 WC Economics; Environmental Studies SC Business & Economics; Environmental Sciences & Ecology GA EH1GM UT WOS:000391511800003 ER PT J AU Verma, S Baig, RBN Nadagouda, MN Len, C Varma, RS AF Verma, Sanny Baig, R. B. Nasir Nadagouda, Mallikarjuna N. Len, Christophe Varma, Rajender S. TI Sustainable pathway to furanics from biomass via heterogeneous organo-catalysis SO GREEN CHEMISTRY LA English DT Article ID GRAPHITIC CARBON NITRIDE; SOLID ACID CATALYST; C-H ACTIVATION; D-FRUCTOSE; DEHYDRATION; CHEMICALS; CONVERSION; EFFICIENT; ENERGY; FUELS AB An organic sulfonated graphitic carbon nitride is synthesized and its application has been demonstrated in the conversion of carbohydrates into furanics and related value-added products. The most important feature of the material is the stability and acidity, which could be utilized at elevated temperatures for cleaving carbohydrates and converting them into biologically important scaffolds and platform chemicals. C1 [Verma, Sanny; Baig, R. B. Nasir; Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, MS 443, Cincinnati, OH 45268 USA. [Nadagouda, Mallikarjuna N.] US EPA, WQMB, WSWRD, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Len, Christophe] Univ Technol Compiegne, Sorbonne Univ, Compiegne, France. RP Varma, RS (reprint author), US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, MS 443, Cincinnati, OH 45268 USA. EM varma.rajender@epa.gov FU Postgraduate Research Program at the National Risk Management Research Laboratory FX S. V. and N. B. R. B. were supported by the Postgraduate Research Program at the National Risk Management Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and the U.S. Environmental Protection Agency. NR 37 TC 0 Z9 0 U1 5 U2 5 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1463-9262 EI 1463-9270 J9 GREEN CHEM JI Green Chem. PY 2017 VL 19 IS 1 BP 164 EP 168 DI 10.1039/c6gc02551j PG 5 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY SC Chemistry; Science & Technology - Other Topics GA EH4GE UT WOS:000391728900018 ER PT J AU Selck, H Adamsen, PB Backhaus, T Banta, GT Bruce, PKH Burton, GA Butts, MB Boegh, E Clague, JJ Dinh, KV Doorn, N Gunnarsson, JS Hauggaard-Nielsen, H Hazlerigg, C Hunka, AD Jensen, J Lin, Y Loureiro, S Miraglia, S Munns, WR Nadim, F Palmqvist, A Ramo, RA Seaby, LP Syberg, K Tangaa, SR Thit, A Windfeld, R Zalewski, M Chapman, PM AF Selck, Henriette Adamsen, Peter B. Backhaus, Thomas Banta, Gary T. Bruce, Peter K. H. Burton, G. Allen, Jr. Butts, Michael B. Boegh, Eva Clague, John J. Dinh, Khuong V. Doorn, Neelke Gunnarsson, Jonas S. Hauggaard-Nielsen, Henrik Hazlerigg, Charles Hunka, Agnieszka D. Jensen, John Lin, Yan Loureiro, Susana Miraglia, Simona Munns, Wayne R., Jr. Nadim, Farrokh Palmqvist, Annemette Ramo, Robert A. Seaby, Lauren P. Syberg, Kristian Tangaa, Stine R. Thit, Amalie Windfeld, Ronja Zalewski, Maciej Chapman, Peter M. TI Assessing and managing multiple risks in a changing worldThe Roskilde recommendations SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Risk assessment; Risk management; Ecosystem services; Climate change; Wicked problems; Multiple environmental stressors ID CUMULATIVE EFFECTS ASSESSMENT; GLOBAL CLIMATE-CHANGE; ECOSYSTEM-SERVICES; DECISION-MAKING; CONTAMINANTS; CHALLENGES; MITIGATION; SEDIMENTS; SEA AB Roskilde University (Denmark) hosted a November 2015 workshop, Environmental RiskAssessing and Managing Multiple Risks in a Changing World. This Focus article presents the consensus recommendations of 30 attendees from 9 countries regarding implementation of a common currency (ecosystem services) for holistic environmental risk assessment and management; improvements to risk assessment and management in a complex, human-modified, and changing world; appropriate development of protection goals in a 2-stage process; dealing with societal issues; risk-management information needs; conducting risk assessment of risk management; and development of adaptive and flexible regulatory systems. The authors encourage both cross-disciplinary and interdisciplinary approaches to address their 10 recommendations: 1) adopt ecosystem services as a common currency for risk assessment and management; 2) consider cumulative stressors (chemical and nonchemical) and determine which dominate to best manage and restore ecosystem services; 3) fully integrate risk managers and communities of interest into the risk-assessment process; 4) fully integrate risk assessors and communities of interest into the risk-management process; 5) consider socioeconomics and increased transparency in both risk assessment and risk management; 6) recognize the ethical rights of humans and ecosystems to an adequate level of protection; 7) determine relevant reference conditions and the proper ecological context for assessments in human-modified systems; 8) assess risks and benefits to humans and the ecosystem and consider unintended consequences of management actions; 9) avoid excessive conservatism or possible underprotection resulting from sole reliance on binary, numerical benchmarks; and 10) develop adaptive risk-management and regulatory goals based on ranges of uncertainty. Environ Toxicol Chem 2017;36:7-16. (c) 2016 SETAC C1 [Selck, Henriette; Banta, Gary T.; Boegh, Eva; Hauggaard-Nielsen, Henrik; Palmqvist, Annemette; Seaby, Lauren P.; Syberg, Kristian; Tangaa, Stine R.; Thit, Amalie; Windfeld, Ronja] Roskilde Univ, Roskilde, Denmark. [Adamsen, Peter B.] Ramboll Environ, Copenhagen, Denmark. [Backhaus, Thomas] Univ Gothenburg, Gothenburg, Sweden. [Bruce, Peter K. H.; Gunnarsson, Jonas S.; Ramo, Robert A.] Stockholm Univ, Stockholm, Sweden. [Burton, G. Allen, Jr.] Univ Michigan, Ann Arbor, MI 48109 USA. [Butts, Michael B.] DHI Grp, Copenhagen, Denmark. [Clague, John J.] Simon Fraser Univ, Burnaby, BC, Canada. [Dinh, Khuong V.; Miraglia, Simona] Tech Univ Denmark, Kongens Lyngby, Denmark. [Doorn, Neelke] Delft Univ Technol, Delft, Netherlands. [Hazlerigg, Charles] Enviresearch, Newcastle Upon Tyne, Tyne & Wear, England. [Hunka, Agnieszka D.] Halmstad Univ, Halmstad, Sweden. [Jensen, John] Aarhus Univ, Silkeborg, Denmark. [Lin, Yan] Norwegian Inst Water Res, Oslo, Norway. [Loureiro, Susana] Univ Aveiro, Dept Biol, Aveiro, Portugal. [Loureiro, Susana] Univ Aveiro, CESAM, Aveiro, Portugal. [Munns, Wayne R., Jr.] US EPA, Narragansett, RI USA. [Nadim, Farrokh] Norwegian Geotech Inst, Oslo, Norway. [Zalewski, Maciej] Polish Acad Sci, European Reg Ctr Ecohydrol, Lodz, Poland. [Chapman, Peter M.] Chapema Environm Strategies, N Vancouver, BC, Canada. RP Chapman, PM (reprint author), Chapema Environm Strategies, N Vancouver, BC, Canada. EM peter@chapmanenviro.com RI Lin, Yan/J-1628-2012; Loureiro, Susana/B-4462-2008; CESAM, UA/M-3762-2015 OI Lin, Yan/0000-0002-8746-3387; Loureiro, Susana/0000-0002-5393-9623; FU Roskilde University; Environmental Risk Research Initiative; CESAM [UID/AMB/50017]; FCT/MEC through national funds; FEDER [POCI-01-0145-FEDER-007638]; PT2020 Partnership Agreement and Compete 2020 FX We thank Roskilde University and their Environmental Risk Research Initiative for organizing, hosting, and funding this Sunrise Workshop. We also thank P. Sibley for very useful review comments. S. Loureiro acknowledges the financial support of CESAM (UID/AMB/50017), to FCT/MEC through national funds, and the cofunding by FEDER (POCI-01-0145-FEDER-007638), within the PT2020 Partnership Agreement and Compete 2020. NR 45 TC 1 Z9 1 U1 18 U2 18 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD JAN PY 2017 VL 36 IS 1 BP 7 EP 16 DI 10.1002/etc.3513 PG 10 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA EG4QW UT WOS:000391029800001 PM 28024105 ER PT J AU Sappington, K Steeger, T AF Sappington, Keith Steeger, Thomas TI The Challenge: Assessment of risks posed by systemic insecticides to hymenopteran pollinators: New perception when we move from laboratory via (semi-)field to landscape scale testing? Response SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Editorial Material C1 [Sappington, Keith; Steeger, Thomas] US EPA, Off Pesticide Programs, Washington, DC 20460 USA. RP Sappington, K (reprint author), US EPA, Off Pesticide Programs, Washington, DC 20460 USA. NR 7 TC 0 Z9 0 U1 2 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD JAN PY 2017 VL 36 IS 1 BP 20 EP 22 PG 3 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA EG4QW UT WOS:000391029800005 ER PT J AU Tumburu, L Andersen, CP Rygiewicz, PT Reichman, JR AF Tumburu, Laxminath Andersen, Christian P. Rygiewicz, Paul T. Reichman, Jay R. TI Molecular and physiological responses to titanium dioxide and cerium oxide nanoparticles in Arabidopsis SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Arabidopsis thaliana; Transcriptome; Growth; Nano-ceria; Nano-titania; Engineered nanoparticles ID THALIANA GENE-EXPRESSION; CHLAMYDOMONAS-REINHARDTII; ENGINEERED NANOPARTICLES; SILVER NANOPARTICLES; TIO2 NANOPARTICLES; BINDING PROTEINS; PLANT DEFENSE; TOXICITY; EXPOSURE; CELLS AB Changes in tissue transcriptomes and productivity of Arabidopsis thaliana were investigated during exposure of plants to 2 widely used engineered metal oxide nanoparticles, titanium dioxide (nano-titania) and cerium dioxide (nano-ceria). Microarray analyses confirmed that exposure to either nanoparticle altered the transcriptomes of rosette leaves and roots, with comparatively larger numbers of differentially expressed genes found under nano-titania exposure. Nano-titania induced more differentially expressed genes in rosette leaves, whereas roots had more differentially expressed genes under nano-ceria exposure. MapMan analyses indicated that although nano-titania up-regulated overall metabolism in both tissues, metabolic processes under nano-ceria remained mostly unchanged. Gene enrichment analysis indicated that both nanoparticles mainly enriched ontology groups such as responses to stress (abiotic and biotic), and defense responses (pathogens), and responses to endogenous stimuli (hormones). Nano-titania specifically induced genes associated with photosynthesis, whereas nano-ceria induced expression of genes related to activating transcription factors, most notably those belonging to the ethylene responsive element binding protein family. Interestingly, there were also increased numbers of rosette leaves and plant biomass under nano-ceria exposure, but not under nano-titania. Other transcriptomic responses did not clearly relate to responses observed at the organism level, possibly because of functional and genomic redundancy in Arabidopsis, which may mask expression of morphological changes, despite discernable responses at the transcriptome level. In addition, transcriptomic changes often relate to transgenerational phenotypic development, and hence it may be productive to direct further experimental work to integrate high-throughput genomic results with longer term changes in subsequent generations. Environ Toxicol Chem 2017;36:71-82. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America. C1 [Tumburu, Laxminath] US EPA, Natl Res Council, Western Ecol Div, Natl Hlth & Environm Effects Res Lab, Corvallis, OR 97333 USA. [Andersen, Christian P.; Rygiewicz, Paul T.; Reichman, Jay R.] US EPA, Western Ecol Div, Natl Hlth & Environm Effects Res Lab, Corvallis, OR USA. RP Tumburu, L (reprint author), US EPA, Natl Res Council, Western Ecol Div, Natl Hlth & Environm Effects Res Lab, Corvallis, OR 97333 USA. EM lax.tumburu@nih.gov FU US Environmental Protection Agency, Western Ecology Division Laboratory FX We thank L. Pokhrel and J. Betts for the help with preparation and characterization of ENP suspensions, and M. Plocher and M. Storm with assistance with plants. We also thank the Genomic Research Core, National Health and Environmental Effects Research Laboratory (NHEERL), US Environmental Protection Agency, for processing the microarrays. The present study was performed while L. Tumburu held a National Research Council Research Associateship Award at the US Environmental Protection Agency, Western Ecology Division Laboratory. NR 69 TC 0 Z9 0 U1 8 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD JAN PY 2017 VL 36 IS 1 BP 71 EP 82 DI 10.1002/etc.3500 PG 12 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA EG4QW UT WOS:000391029800011 PM 27212052 ER PT J AU Villeneuve, DL Jensen, KM Cavallin, JE Durhan, EJ Garcia-Reyero, N Kahl, MD Leino, RL Makynen, EA Wehmas, LC Perkins, EJ Ankley, GT AF Villeneuve, Daniel L. Jensen, Kathleen M. Cavallin, Jenna E. Durhan, Elizabeth J. Garcia-Reyero, Natalia Kahl, Michael D. Leino, Richard L. Makynen, Elizabeth A. Wehmas, Leah C. Perkins, Edward J. Ankley, Gerald T. TI Effects of the antimicrobial contaminant triclocarban, and co-exposure with the androgen 17-trenbolone, on reproductive function and ovarian transcriptome of the fathead minnow (Pimephales promelas) SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Adverse outcome pathway; Contaminants of emerging concern; Reproductive toxicity; Toxicity mechanisms; Endocrine-disrupting compounds ID ENDOCRINE DISRUPTION; GENE-EXPRESSION; WASTE-WATER; IN-VITRO; TRICLOSAN; BIOACCUMULATION; VINCLOZOLIN; ANNOTATION; OVULATION; KEGG AB Triclocarban (TCC) is an antimicrobial agent routinely detected in surface waters that has been hypothesized to interact with the vertebrate endocrine system. The present study examined the effects of TCC alone and in combination with the model endocrine disruptor 17-trenbolone (TRB) on fish reproductive function. Adult Pimephales promelas were continuously exposed to either 1 mu g TCC/L or 5 mu g TCC/L, to 0.5 mu g TRB/L, or to a mixture (MIX) of 5 mu g TCC/L and 0.5 mu g TRB/L for 22 d, and a variety of reproductive and endocrine-related endpoints were examined. Cumulative fecundity was significantly reduced in fathead minnows exposed to TRB, MIX, or 5 mu g TCC/L. Exposure to 1 mu g TCC/L had no effect on reproduction. In general, both TRB and MIX treatments caused similar physiological effects, evoking significant reductions in female plasma vitellogenin, estradiol, and testosterone, and significant increases in male plasma estradiol. Based on analysis of the ovarian transcriptome, there were potential pathway impacts that were common to both TRB- and TCC-containing treatment groups. In most cases, however, those pathways were more plausibly linked to differences in reproductive status than to androgen-specific functions. Overall, TCC was reproductively toxic to fish at concentrations at or near those that have been measured in surface water. There was little evidence that TCC elicits reproductive toxicity through a specific mode of endocrine or reproductive action, nor that it could augment the androgenic effects of TRB. Nonetheless, the relatively small margin of safety between some measured environmental concentrations and effect concentrations suggests that concern is warranted. Environ Toxicol Chem 2017;36:231-242. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America. C1 [Villeneuve, Daniel L.; Jensen, Kathleen M.; Cavallin, Jenna E.; Durhan, Elizabeth J.; Kahl, Michael D.; Makynen, Elizabeth A.; Wehmas, Leah C.; Ankley, Gerald T.] US EPA, Mid Continent Ecol Div, Duluth, MN 55804 USA. [Garcia-Reyero, Natalia; Perkins, Edward J.] US Army Engn Res & Dev Ctr, Vicksburg, MS USA. [Leino, Richard L.] Univ Minnesota Duluth, Sch Med, Dept Anat & Cell Biol, Duluth, MN USA. [Wehmas, Leah C.] Oregon State Univ, Environm & Mol Toxicol, Corvallis, OR 97331 USA. RP Villeneuve, DL (reprint author), US EPA, Mid Continent Ecol Div, Duluth, MN 55804 USA. EM villeneuve.dan@epa.gov FU USEPA Chemical Safety for Sustainability (CSS) Research Program FX The authors thank L. Thomas and S. Seidl for additional technical support and J. Haselman for critical feedback on the manuscript. Funding for this work was provided in part by the USEPA Chemical Safety for Sustainability (CSS) Research Program. NR 51 TC 0 Z9 0 U1 9 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD JAN PY 2017 VL 36 IS 1 BP 231 EP 242 DI 10.1002/etc.3531 PG 12 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA EG4QW UT WOS:000391029800029 PM 27312088 ER PT S AU Garmire, LX Gliske, S Nguyen, QC Chen, JH Nemati, S Van Horn, JD Moore, JH Shreffler, C Dunn, M AF Garmire, Lana X. Gliske, Stephen Nguyen, Quynh C. Chen, Jonathan H. Nemati, Shamim Van Horn, John D. Moore, Jason H. Shreffler, Carol Dunn, Michelle BE Altman, RB Dunker, AK Hunter, L Ritchie, MD Murray, T Klein, TE TI THE TRAINING OF NEXT GENERATION DATA SCIENTISTS IN BIOMEDICINE SO PACIFIC SYMPOSIUM ON BIOCOMPUTING 2017 SE Biocomputing Series LA English DT Proceedings Paper CT 22nd Pacific Symposium on Biocomputing (PSB) CY JAN 04-08, 2017 CL HI ID BIG DATA; HEALTH AB With the booming of new technologies, biomedical science has transformed into digitalized, data intensive science. Massive amount of data need to be analyzed and interpreted, demand a complete pipeline to train next generation data scientists. To meet this need, the trans-institutional Big Data to Knowledge (BD2K) Initiative has been implemented since 2014, complementing other NIH institutional efforts. In this report, we give an overview the BD2K K01 mentored scientist career awards, which have demonstrated early success. We address the specific trainings needed in representative data science areas, in order to make the next generation of data scientists in biomedicine. C1 [Garmire, Lana X.] Univ Hawaii, Ctr Canc, Program Epidemiol, Honolulu, HI 96813 USA. [Gliske, Stephen] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA. [Nguyen, Quynh C.] Univ Utah, Dept Hlth Kinesiol & Recreat, Salt Lake City, UT 84112 USA. [Chen, Jonathan H.] Stanford Univ, Dept Med, Stanford, CA 94305 USA. [Nemati, Shamim] Emory Univ, Dept Biomed Informat, Atlanta, GA 30322 USA. [Van Horn, John D.] Univ Southern Calif, Mark & Mary Stevens Neuroimaging & Informat Inst, Los Angeles, CA 90032 USA. [Moore, Jason H.] Univ Penn, Inst Biomed Informat, Philadelphia, PA 19104 USA. [Shreffler, Carol] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC 27709 USA. [Dunn, Michelle] Natl Inst Hlth, Office Associate Director Data Sci ADDA, Bethesda, MD 20892 USA. RP Garmire, LX (reprint author), Univ Hawaii, Ctr Canc, Program Epidemiol, Honolulu, HI 96813 USA. EM LGarmire@Hawaii.edu NR 15 TC 0 Z9 0 U1 3 U2 3 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE SN 2335-6936 BN 978-981-3207-81-3; 978-981-3207-80-6 J9 BIOCOMPUTING PY 2017 BP 640 EP 645 PG 6 WC Biotechnology & Applied Microbiology; Mathematical & Computational Biology SC Biotechnology & Applied Microbiology; Mathematical & Computational Biology GA BG7FY UT WOS:000391254200059 ER PT J AU Chen, Y Du, W Shen, G Zhuo, S Zhu, X Shen, H Huang, Y Su, S Lin, N Pei, L Zheng, X Wu, J Duan, Y Wang, X Liu, W Wong, M Tao, S AF Chen, Y. Du, W. Shen, G. Zhuo, S. Zhu, X. Shen, H. Huang, Y. Su, S. Lin, N. Pei, L. Zheng, X. Wu, J. Duan, Y. Wang, X. Liu, W. Wong, M. Tao, S. TI Household air pollution and personal exposure to nitrated and oxygenated polycyclic aromatics (PAHs) in rural households: Influence of household cooking energies SO INDOOR AIR LA English DT Article DE Nitrated as polycyclic aromatic hydrocarbons; Oxygenated as polycyclic aromatic hydrocarbons; Household air; Personal exposure; Household energies; Smoking behavior ID DEVELOPING-COUNTRIES; AMBIENT AIR; NORTHERN CHINA; HYDROCARBONS; COMBUSTION; EMISSIONS; URBAN; RISK; PRODUCTS; SHANXI AB Residential solid fuels are widely consumed in rural China, contributing to severe household air pollution for many products of incomplete combustion, such as polycyclic aromatic hydrocarbons (PAHs) and their polar derivatives. In this study, concentrations of nitrated and oxygenated PAH derivatives (nPAHs and oPAHs) for household and personal air were measured and analyzed for influencing factors like smoking and cooking energy type. Concentrations of nPAHs and oPAHs in kitchens were higher than those in living rooms and in outdoor air. Exposure levels measured by personal samplers were lower than levels in indoor air, but higher than outdoor air levels. With increasing molecular weight, individual compounds tended to be more commonly partitioned to particulate matter (PM); moreover, higher molecular weight nPAHs and oPAHs were preferentially found in finer particles, suggesting a potential for increased health risks. Smoking behavior raised the concentrations of nPAHs and oPAHs in personal air significantly. People who cooked food also had higher personal exposures. Cooking and smoking have a significant interaction effect on personal exposure. Concentrations in kitchens and personal exposure to nPAHs and oPAHs for households using wood and peat were significantly higher than for those using electricity and liquid petroleum gas (LPG). C1 [Chen, Y.; Du, W.; Shen, G.; Zhuo, S.; Zhu, X.; Shen, H.; Huang, Y.; Su, S.; Lin, N.; Wang, X.; Liu, W.; Tao, S.] Peking Univ, Coll Urban & Environm Sci, Lab Earth Surface Proc, Beijing, Peoples R China. [Pei, L.; Zheng, X.; Wu, J.] Peking Univ, Inst Populat Res, Beijing, Peoples R China. [Duan, Y.] Shanxi Agr Univ, Coll Resources & Environm, Jinzhong, Shanxi, Peoples R China. [Wong, M.] Hong Kong Inst Educ, Consortium Hlth Environm Educ & Res CHEER, Dept Sci & Environm Studies, Hong Kong, Hong Kong, Peoples R China. [Shen, G.] US EPA, NRMRL, Durham, NC USA. RP Tao, S (reprint author), Peking Univ, Yifu 2 Bldg,5 Yiheyuan Rd, Beijing 100871, Peoples R China. EM taos@pku.edu.cn RI Shen, Huizhong/E-8152-2017 OI Shen, Huizhong/0000-0003-1335-8477 FU National Natural Science Foundation of China [41390240, 41130754, 41161160559] FX Funding for this study was provided by the National Natural Science Foundation of China (41390240, 41130754, 41161160559). Thanks are due to Li Zhao from Maternal and Children Health Care Service Center in Heshun County; Haochen Wang, Yafei Wang, and Yilan Liao from Peking University; Yangyang Song, Li Zhao, and Beibei Song from Shanxi Agricultural University; and the rural residents who helped and cooperated with us in the field sampling. NR 25 TC 1 Z9 1 U1 11 U2 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0905-6947 EI 1600-0668 J9 INDOOR AIR JI Indoor Air PD JAN PY 2017 VL 27 IS 1 BP 169 EP 178 DI 10.1111/ina.12300 PG 10 WC Construction & Building Technology; Engineering, Environmental; Public, Environmental & Occupational Health SC Construction & Building Technology; Engineering; Public, Environmental & Occupational Health GA EG4RY UT WOS:000391032600016 PM 27008622 ER PT J AU Simpson, RD AF Simpson, R. David TI The simple but not-too-simple valuation of ecosystem services: basic principles and an illustrative example SO JOURNAL OF ENVIRONMENTAL ECONOMICS AND POLICY LA English DT Article DE Ecosystem services; exponential function; riparian buffers; diminishing returns; marginal value; removal rate; opportunity cost ID BENEFIT TRANSFER; RIPARIAN BUFFERS; REMOVAL; FOREST AB Albert Einstein is reputed to have said 'Everything should be made as simple as possible, but not simpler.' This is good advice for valuing ecosystem services. The fundamental principle of economic valuation is simple, but powerful: value is determined on the margin. This means that context is crucial in estimating ecosystem service values and, therefore, 'benefit transfer' exercises that fail to account for location and relative abundance are, at best, meaningless, and at worst, counterproductive. I illustrate the principles of valuation with the example of water purification by riparian buffers. Values can differ greatly over even relatively small areas, and some ostensibly paradoxical results can arise. C1 [Simpson, R. David] US EPA, Natl Ctr Environm Econ, Washington, DC 20460 USA. RP Simpson, RD (reprint author), US EPA, Natl Ctr Environm Econ, Washington, DC 20460 USA. EM simpson.david@epa.gov NR 36 TC 0 Z9 0 U1 6 U2 6 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 2160-6544 EI 2160-6552 J9 J ENVIRON ECON POLIC JI J. Environ. Econ. Policy PY 2017 VL 6 IS 1 BP 96 EP 106 DI 10.1080/21606544.2016.1184594 PG 11 WC Environmental Studies SC Environmental Sciences & Ecology GA EG6GR UT WOS:000391143100006 ER PT J AU Ilacqua, V Dawson, J Breen, M Singer, S Berg, A AF Ilacqua, Vito Dawson, John Breen, Michael Singer, Sarany Berg, Ashley TI Effects of climate change on residential infiltration and air pollution exposure SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY LA English DT Article DE air exchange; climate change; indoor exposure; infiltration ID LUNG-CANCER; EXCHANGE-RATES; INDOOR RADON; DECAY-RATES; OUTDOOR; OZONE; URBAN; HOMES; RISK; AMERICAN AB Air exchange through infiltration is driven partly by indoor/outdoor temperature differences, and as climate change increases ambient temperatures, such differences could vary considerably even with small ambient temperature increments, altering patterns of exposures to both indoor and outdoor pollutants. We calculated changes in air fluxes through infiltration for prototypical detached homes in nine metropolitan areas in the United States (Atlanta, Boston, Chicago, Houston, Los Angeles, Minneapolis, New York, Phoenix, and Seattle) from 1970-2000 to 2040-2070. The Lawrence Berkeley National Laboratory model of infiltration was used in combination with climate data from eight regionally downscaled climate models from the North American Regional Climate Change Assessment Program. Averaged over all study locations, seasons, and climate models, air exchange through infiltration would decrease by similar to 5%. Localized increased infiltration is expected during the summer months, up to 20-30%. Seasonal and daily variability in infiltration are also expected to increase, particularly during the summer months. Diminished infiltration in future climate scenarios may be expected to increase exposure to indoor sources of air pollution, unless these ventilation reductions are otherwise compensated. Exposure to ambient air pollution, conversely, could be mitigated by lower infiltration, although peak exposure increases during summer months should be considered, as well as other mechanisms. C1 [Ilacqua, Vito; Dawson, John; Breen, Michael; Singer, Sarany; Berg, Ashley] US EPA, 1200 Penn Ave NW 8726P, Washington, DC 20460 USA. RP Ilacqua, V (reprint author), US EPA, 1200 Penn Ave NW 8726P, Washington, DC 20460 USA. EM ilacqua.vito@epa.gov FU National Science Foundation; United States Department of Energy; National Oceanic and Atmospheric Administration; United States Environmental Protection Agency Office of Research and Development FX We wish to thank the NARCCAP for providing the data used in this paper. NARCCAP is funded by the National Science Foundation, the United States Department of Energy, the National Oceanic and Atmospheric Administration, and the United States Environmental Protection Agency Office of Research and Development. We also thank Bryan Bloomer, for inspiring conversations about climate change leading to this work, and about the role of the climate penalty on ambient air pollution. The views expressed in this article are those of the authors and do not necessarily reflect the views or policies of the United States Environmental Protection Agency. NR 51 TC 0 Z9 0 U1 7 U2 7 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1559-0631 EI 1559-064X J9 J EXPO SCI ENV EPID JI J. Expo. Sci. Environ. Epidemiol. PD JAN-FEB PY 2017 VL 27 IS 1 BP 16 EP 23 DI 10.1038/jes.2015.38 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA EG5KH UT WOS:000391082200003 PM 26015076 ER PT J AU Wilson, A Reich, BJ Nolte, CG Spero, TL Hubbell, B Rappold, AG AF Wilson, Ander Reich, Brian J. Nolte, Christopher G. Spero, Tanya L. Hubbell, Bryan Rappold, Ana G. TI Climate change impacts on projections of excess mortality at 2030 using spatially varying ozone-temperature risk surfaces SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY LA English DT Article DE climate change; mortality; ozone; ozone-temperature interaction ID US URBAN COMMUNITIES; SHORT-TERM MORTALITY; UNITED-STATES; AIR-QUALITY; HEALTH IMPACTS; SIMULATIONS; CITIES AB We project the change in ozone-related mortality burden attributable to changes in climate between a historical (1995-2005) and near-future (2025-2035) time period while incorporating a non-linear and synergistic effect of ozone and temperature on mortality. We simulate air quality from climate projections varying only biogenic emissions and holding anthropogenic emissions constant, thus attributing changes in ozone only to changes in climate and independent of changes in air pollutant emissions. We estimate non-linear, spatially varying, ozone-temperature risk surfaces for 94 US urban areas using observed data. Using the risk surfaces and climate projections we estimate daily mortality attributable to ozone exceeding 40 p.p.b. (moderate level) and 75 p.p.b. (US ozone NAAQS) for each time period. The average increases in city-specific median April-October ozone and temperature between time periods are 1.02 p.p.b. and 1.94 degrees F; however, the results varied by region. Increases in ozone because of climate change result in an increase in ozone mortality burden. Mortality attributed to ozone exceeding 40 p.p.b. increases by 7.7% (1.6-14.2%). Mortality attributed to ozone exceeding 75 p.p.b. increases by 14.2% (1.6 28.9%). The absolute increase in excess ozone mortality is larger for changes in moderate ozone levels, reflecting the larger number of days with moderate ozone levels. C1 [Wilson, Ander] Harvard TH Chan Sch Publ Hlth, Dept Biostat, 655 Huntington Ave, Boston, MA 02115 USA. [Reich, Brian J.] North Carolina State Univ, Dept Stat, Raleigh, NC USA. [Nolte, Christopher G.; Spero, Tanya L.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Hubbell, Bryan] US EPA, Off Air & Radiat, Hlth & Environm Impacts Div, Res Triangle Pk, NC 27711 USA. [Rappold, Ana G.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. RP Wilson, A (reprint author), Harvard TH Chan Sch Publ Hlth, Dept Biostat, 655 Huntington Ave, Boston, MA 02115 USA. EM awilson@hsph.harvard.edu RI Nolte, Christopher/H-4345-2012 OI Nolte, Christopher/0000-0001-5224-9965 FU United States Environmental Protection Agency through its Office of Research and Development; NIH [ES007142, R21 ES022585-01, 5R01ES014843-02, R21ES022795-01A1]; Research Participation Program for the US Environmental Protection Agency, Office of Research and Development; EPA [R835228] FX The United States Environmental Protection Agency through its Office of Research and Development funded and managed the research described here. It has been subjected to the Agency's administrative review and approved for publication. Support for AW: this research was supported in part by NIH Grants ES007142 and R21 ES022585-01, and by an appointment to the Research Participation Program for the US Environmental Protection Agency, Office of Research and Development, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and EPA. Support for BJR: this research was supported by NIH Grants 5R01ES014843-02 and R21ES022795-01A1 and EPA Grant R835228. NR 29 TC 0 Z9 0 U1 9 U2 9 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1559-0631 EI 1559-064X J9 J EXPO SCI ENV EPID JI J. Expo. Sci. Environ. Epidemiol. PD JAN-FEB PY 2017 VL 27 IS 1 BP 118 EP 124 DI 10.1038/jes.2016.14 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA EG5KH UT WOS:000391082200017 PM 27005744 ER PT J AU Sell, TK Boddie, C McGinty, EE Pollack, K Smith, KC Burke, TA Rutkow, L AF Sell, Tara Kirk Boddie, Crystal McGinty, Emma E. Pollack, Keshia Smith, Katherine Clegg Burke, Thomas A. Rutkow, Lainie TI Media Messages and Perception of Risk for Ebola Virus Infection, United States SO EMERGING INFECTIOUS DISEASES LA English DT Article ID AGREEMENT AB News media have been blamed for sensationalizing Ebola in the United States, causing unnecessary alarm. To investigate this issue, we analyzed US-focused news stories about Ebola virus disease during July 1 November 30, 2014. We found frequent use of risk-elevating messages, which may have contributed to increased public concern. C1 [Sell, Tara Kirk; Boddie, Crystal] UPMC Ctr Hlth Secur, Baltimore, MD 21202 USA. [Sell, Tara Kirk; Boddie, Crystal; McGinty, Emma E.; Pollack, Keshia; Smith, Katherine Clegg; Rutkow, Lainie] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Burke, Thomas A.] US EPA, Washington, DC 20460 USA. RP Sell, TK (reprint author), UPMC Ctr Hlth Secur, Baltimore, MD 21202 USA.; Sell, TK (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, Rm 513,624 N Broadway, Baltimore, MD 21205 USA. EM tsell1@jhu.edu FU Johns Hopkins Sommer Scholars Program FX We acknowledge the contributions of Amesh Adalja and Matthew Watson for their review of the initial coding instrument. Dr. Burke contributed to this work while serving as professor at Johns Hopkins. The views expressed are his own and do not necessarily reflect the policy positions of the US Environmental Protection Agency. Support for this research was provided to T.K.S. by the Johns Hopkins Sommer Scholars Program. NR 16 TC 0 Z9 0 U1 21 U2 21 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JAN PY 2017 VL 23 IS 1 BP 108 EP 111 DI 10.3201/eid2301.160589 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA EG2AV UT WOS:000390836400018 PM 27983495 ER PT J AU Obrycki, JF Scheckel, KG Basta, NT AF Obrycki, John F. Scheckel, Kirk G. Basta, Nicholas T. TI Soil solution interactions may limit Pb remediation using P amendments in an urban soil SO ENVIRONMENTAL POLLUTION LA English DT Article DE Lead (Pb); Phosphorus (P); Bioaccessibility; In vitro; Remediation ID LEAD-CONTAMINATED SOIL; RAY-ABSORPTION SPECTROSCOPY; IN-SITU REMEDIATION; PHOSPHORIC-ACID; PHOSPHATE; IMMOBILIZATION; SPECIATION; CHLOROPYROMORPHITE; BIOAVAILABILITY; PREVENTION AB Lead (Pb) contaminated soils are a potential exposure hazard to the public. Amending soils with phosphorus (P) may reduce Pb soil hazards. Soil from Cleveland, OH containing 726 +/- 14 mg Pb kg(-1) was amended in a laboratory study with bone meal and triple super phosphate (TSP) at 5:1 P:Pb molar ratios. Soil was acidified, neturalized and re-acidified to encourage Pb phosphate formation. PRSTM-probes were used to evaluate changes in soil solution chemistry. Soil acidification did not decrease in vitro bioaccessible (IVBA) Pb using either a pH 1.5, 0.4 M glycine solution or a pH 2.5 solution with organic acids. PRSTM-probe data found soluble Pb increased 10-fold in acidic conditions compared to circumnetural pH conditions. In acidic conditions (p = 3-4), TSP treated soils increased detected P 10-fold over untreated soils. Bone meal application did not increase PRSTM-probe detected 13, indicating there may have been insufficient P to react with Pb. X-ray absorption spectroscopy suggested a 10% increase in pyromorphite formation for the TSP treated soil only. Treatments increased soil electrical conductivity above 16 mS cm(-1), potentially causing a new salinity hazard. This study used a novel approach by combining the human ingestion endpoint, PRSTM-probes, and X-ray absorption spectroscopy to evaluate treatment efficacy. PRSTM-probe data indicated potentially excess Ca relative to P across incubation steps that could have competed with Pb for soluble P. More research is needed to characterize soil solutions in Pb contaminated urban soils to identify where P treatments might be effective and when competing cations, such as Ca, Fe, and Zn may limit low rate P applications for treating Pb soils. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Obrycki, John F.; Basta, Nicholas T.] Ohio State Univ, Sch Environm & Nat Resources, 210 Kottman Hall,2021 Coffey Rd, Columbus, OH 43210 USA. [Scheckel, Kirk G.] US EPA, Natl Risk Management Res Lab, Land Remediat & Pollut Control Div, Cincinnati, OH 45224 USA. RP Basta, NT (reprint author), Ohio State Univ, Sch Environm & Nat Resources, 210 Kottman Hall,2021 Coffey Rd, Columbus, OH 43210 USA. EM basta.4@osu.edu OI Scheckel, Kirk/0000-0001-9326-9241 FU Western Ag Innovations Student Research Award; Ohio Agricultural Research and Development Center (USDA NIFA) [OH001336]; Ohio State University, Columbus, OH [43210]; Ohio State University, Columbus, OH through a Distinguished University Fellowship [43210]; Ohio Agricultural Research and Development Center College of Food, Agricultural, and Environmental Sciences Graduate Research Fellowship; School of Environment and Natural Resources FX PRSTM-probe analysis supported by a 2015 Western Ag Innovations Student Research Award. Other support included partial salary for N.T. Basta by state and federal funds appropriated to the Ohio Agricultural Research and Development Center (USDA NIFA OH001336), The Ohio State University, Columbus, OH, 43210. Other support included graduate student support for J.F. Obrycki from The Ohio State University, Columbus, OH, 43210 through a Distinguished University Fellowship, Ohio Agricultural Research and Development Center College of Food, Agricultural, and Environmental Sciences Graduate Research Fellowship, and School of Environment and Natural Resources funding. NR 40 TC 0 Z9 0 U1 16 U2 16 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0269-7491 EI 1873-6424 J9 ENVIRON POLLUT JI Environ. Pollut. PD JAN PY 2017 VL 220 BP 549 EP 556 DI 10.1016/j.envpol.2016.10.002 PN A PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA EG0QG UT WOS:000390736700060 PM 27751639 ER PT J AU Szura, K McKinney, RA Wigand, C Oczkowski, A Hanson, A Gurak, J Garate, M AF Szura, Katelyn McKinney, Richard A. Wigand, Cathleen Oczkowski, Autumn Hanson, Alana Gurak, John Garate, Melanie TI Burrowing and foraging activity of marsh crabs under different inundation regimes SO JOURNAL OF EXPERIMENTAL MARINE BIOLOGY AND ECOLOGY LA English DT Article DE Salt marsh; Uca spp.; Crab burrowing; Stable isotope ID ENGLAND SALT-MARSH; SEA-LEVEL RISE; BELOW-GROUND HERBIVORY; UCA-PUGNAX SMITH; FIDDLER-CRAB; SPARTINA-ALTERNIFLORA; NUTRIENT ENRICHMENT; SURFACE ELEVATION; DIE-OFF; DIEBACK AB New England salt marshes are susceptible to degradation and habitat loss as a result of increased periods of inundation as sea levels rise. Increased inundation may exacerbate marsh degradation that can result from crab burrowing and foraging. Most studies to date have focused on how crab burrowing and foraging can impact the dominant low marsh plant species, Spartina altemiflora. Here we used a mesocosm experiment to examine the relationship of foraging and burrowing activity in two dominant New England crab species, Sesarma reticulatum and Uca pugilator, and the combined effect of inundation, on the dominant high marsh plant species Spartina patens using a 3 x 2 factorial design with three crab treatments (Sesame, Uca, control) at two levels of inundation (low, high). Plants were labeled with a nitrogen (N) stable isotope tracer to estimate plant consumption by the two crab species. At both levels of inundation, we found that S. reticulatum had a significant negative impact on both above- and below-ground biomass by physically clipping and uprooting the plants, whereas U. pugilator had no significant impact. Low inundation treatments for both crab species had significantly greater aboveground biomass than high inundation. Stable N isotope tracer levels were roughly the same for both S. reticulatum and U. pugilator tissue, suggesting that the impact of S. reticulatum on S. patens was not through consumption of the plants. Overall, our results suggest the potential for S. reticulatum to negatively impact marsh stability, and that effects of crab foraging behavior may be heightened by increased inundation. Published by Elsevier B.V. C1 [Szura, Katelyn; Garate, Melanie] Univ Rhode Isl, Dept Biol Sci, 120 Flagg Rd, Kingston, RI 02881 USA. [McKinney, Richard A.; Wigand, Cathleen; Oczkowski, Autumn; Hanson, Alana] US EPA, Atlantic Ecol Div, ORD NHEERL, 27 Tarzwell Dr, Narragansett, RI 02882 USA. [Gurak, John] Scripps Res Inst, 10550 N Torrey Pines Rd, La Jolla, CA 92037 USA. RP McKinney, RA (reprint author), US EPA, Atlantic Ecol Div, ORD NHEERL, 27 Tarzwell Dr, Narragansett, RI 02882 USA. EM mckinney.rick@epa.gov FU U.S. Environmental Protection Agency FX We thank Kenneth Miller for assistance with statistical analyses and Kevin Kelly for assistance in maintaining the flow-through seawater system. Nicole Gutierrez, Richard Pruell, and Rose Martin provided helpful input on an earlier version of this manuscript. This report is contribution number ORD-016161 of the U.S. EPA's Office of Research and Development, National Health and Environmental Effects Research Laboratory, Atlantic Ecology Division. Although the research described in this article has been funded in part by the U.S. Environmental Protection Agency, it has not been subjected to Agency review. Therefore, it does not necessarily reflect the views of the Agency. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 58 TC 0 Z9 0 U1 19 U2 19 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0981 EI 1879-1697 J9 J EXP MAR BIOL ECOL JI J. Exp. Mar. Biol. Ecol. PD JAN PY 2017 VL 486 BP 282 EP 289 DI 10.1016/j.jembe.2016.10.029 PG 8 WC Ecology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA EF7FP UT WOS:000390495800034 ER PT J AU Chandler, JC Perez-Mendez, A Paar, J Doolittle, MM Bisha, B Goodridge, LD AF Chandler, J. C. Perez-Mendez, A. Paar, J., III Doolittle, M. M. Bisha, B. Goodridge, L. D. TI Field-based evaluation of a male-specific (F plus ) RNA coliphage concentration method SO JOURNAL OF VIROLOGICAL METHODS LA English DT Article ID MICROBIAL SOURCE TRACKING; REVERSE-TRANSCRIPTASE-PCR; RESIN-BASED METHOD; ENTERIC VIRUSES; FRESH-WATER; MICROPOROUS FILTERS; FECAL POLLUTION; DRINKING-WATER; TAP WATER; BACTERIOPHAGES AB Fecal contamination of water poses a significant risk to public health due to the potential presence of pathogens, including enteric viruses. Therefore, sensitive, reliable and easy to use methods for the concentration, detection and quantification of microorganisms associated with the safety and quality of water are needed. In this study, we performed a field evaluation of an anion exchange resin-based method to concentrate male-specific (F+) RNA coliphages (FRNA), fecal indicator organisms, from diverse environmental waters that were suspected to be contaminated with feces. In this system, FRNA coliphages are adsorbed to anion exchange resin and direct nucleic acid isolation is performed, yielding a sample amenable to real-time reverse transcriptase (RT)-PCR detection. Matrix-dependent inhibition of this method was evaluated using known quantities of spiked FRNA coliphages belonging to four genogroups (GI, GII, GII and GIV). RT-PCR-based detection was successful in 97%, 72%, 85% and 98% of the samples spiked (10(6) pfu/l) with GI, GII, GIII and GIV, respectively. Differential FRNA coliphage genogroup detection was linked to inhibitors that altered RT-PCR assay efficiency. No association between inhibition and the physicochemical properties of the water samples was apparent. Additionally, the anion exchange resin method facilitated detection of naturally present FRNA coliphages in 40 of 65 environmental water samples (61.5%), demonstrating the viability of this system to concentrate FRNA coliphages from water. (C) 2016 Elsevier B.V. All rights reserved. C1 [Chandler, J. C.] Anim & Plant Hlth Inspect Serv, Natl Wildlife Res Ctr, Wildlife Serv, USDA, Ft Collins, CO USA. [Perez-Mendez, A.] Colorado State Univ, Dept Anim Sci, Ft Collins, CO 80523 USA. [Paar, J., III] US EPA, New England Reg Lab, North Chelmsford, MA USA. [Doolittle, M. M.] US EPA, ESAT ContractorTechLaw Inc, New England Reg Lab, North Chelmsford, MA USA. [Bisha, B.] Univ Wyoming, Dept Anim Sci, Laramie, WY 82071 USA. [Goodridge, L. D.] McGill Univ, Dept Food Sci & Agr Chem, Ste Anne De Bellevue, PQ, Canada. RP Goodridge, LD (reprint author), McGill Univ, Dept Food Sci & Agr Chem, Ste Anne De Bellevue, PQ, Canada. EM lawrence.goodridge@mcgill.ca FU National Institute of Food and Agriculture (NIFA) [2009-51110, 2009-01208] FX This work was supported by a grant from the National Institute of Food and Agriculture (NIFA) (2009-51110, 2009-01208). A United States patent application (12/693,139) has been filed on this method. NR 35 TC 0 Z9 0 U1 2 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-0934 EI 1879-0984 J9 J VIROL METHODS JI J. Virol. Methods PD JAN PY 2017 VL 239 BP 9 EP 16 DI 10.1016/j.jviromet.2016.10.007 PG 8 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Virology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Virology GA EF9AY UT WOS:000390624300002 PM 27777078 ER PT J AU Guignet, D Griffiths, C Klemick, H Walsh, PJ AF Guignet, Dennis Griffiths, Charles Klemick, Heather Walsh, Patrick J. TI The Implicit Price of Aquatic Grasses SO MARINE RESOURCE ECONOMICS LA English DT Article DE Aquatic grass; Chesapeake Bay; ecosystem service; hedonic; property value; SAV; submerged aquatic vegetation; water quality ID WATER-QUALITY; PROPERTY-VALUES; CHESAPEAKE BAY; SEAGRASS; ECOSYSTEM; MODELS; EUTROPHICATION; VEGETATION; AUSTRALIA; BENEFITS AB Submerged aquatic vegetation (SAV) in the Chesapeake Bay is well below half of its historic levels, largely due to excessive nutrient and sediment loads degrading water quality. SAV provides important ecosystem functions, many of which are beneficial to local residents. To understand the implicit value residents place on SAV and the ecosystem services it provides, we undertake a hedonic property value study using residential transactions in 11 Maryland counties adjacent to the Chesapeake Bay. These data are matched to high resolution maps of SAV coverage. We pose a quasi-experimental comparison and examine how the prices of homes near the waterfront vary with the presence of SAV. On average, waterfront and near-waterfront homes within 200 meters of the shore sell at about a 6.5% premium when SAV is present. Applying these estimates to the 185,000-acre SAV attainment goal suggests total property value gains on the order of $436 million. C1 [Guignet, Dennis; Griffiths, Charles; Klemick, Heather] US EPA, Natl Ctr Environm Econ, 1200 Penn Ave NW, Washington, DC 20460 USA. [Walsh, Patrick J.] Landcare Res, 231 Morrin Rd, Auckland 1072, New Zealand. RP Guignet, D (reprint author), US EPA, Natl Ctr Environm Econ, 1200 Penn Ave NW, Washington, DC 20460 USA. EM guignet.dennis@epa.gov; griffiths.charles@epa.gov; klemick.heather@epa.gov; walshp@landcareresearch.co.nz FU US Environmental Protection Agency FX This research was supported by funding from the US Environmental Protection Agency. It has not been subjected to the Agency's peer and policy review. No official Agency endorsement should be inferred. Views expressed are solely those of the authors. We thank Lisa Wainger and participants at the Northeastern Agricultural and Resource Economic Association's 2014 Meetings and Resources for the Future's Academic Seminar Series for helpful comments. NR 49 TC 0 Z9 0 U1 7 U2 7 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0738-1360 EI 2334-5985 J9 MAR RESOUR ECON JI Mar. Resour. Econ. PY 2017 VL 32 IS 1 BP 21 EP 41 DI 10.1086/689201 PG 21 WC Economics; Environmental Studies; Fisheries SC Business & Economics; Environmental Sciences & Ecology; Fisheries GA EF7OW UT WOS:000390519900002 ER PT J AU Sundstrom, SM Eason, T Nelson, RJ Angeler, DG Barichievy, C Garmestani, AS Graham, NAJ Granholm, D Gunderson, L Knutson, M Nash, KL Spanbauer, T Stow, CA Allen, CR AF Sundstrom, Shana M. Eason, Tarsha Nelson, R. John Angeler, David G. Barichievy, Chris Garmestani, Ahjond S. Graham, Nicholas A. J. Granholm, Dean Gunderson, Lance Knutson, Melinda Nash, Kirsty L. Spanbauer, Trisha Stow, Craig A. Allen, Craig R. TI Detecting spatial regimes in ecosystems SO ECOLOGY LETTERS LA English DT Article DE Boundary detection; community change; Fisher information; regime shifts; spatial regimes; spatial resilience ID EARLY-WARNING SIGNALS; PLANT-SPECIES DISTRIBUTIONS; NORTHERN BERING-SEA; CLIMATE-CHANGE; ZOOPLANKTON COMMUNITIES; ECOLOGICAL BOUNDARIES; FISHER INFORMATION; LEADING INDICATOR; ISOTOPE RATIOS; CHANGE IMPACTS AB Research on early warning indicators has generally focused on assessing temporal transitions with limited application of these methods to detecting spatial regimes. Traditional spatial boundary detection procedures that result in ecoregion maps are typically based on ecological potential (i.e. potential vegetation), and often fail to account for ongoing changes due to stressors such as land use change and climate change and their effects on plant and animal communities. We use Fisher information, an information theory-based method, on both terrestrial and aquatic animal data (U.S. Breeding Bird Survey and marine zooplankton) to identify ecological boundaries, and compare our results to traditional early warning indicators, conventional ecoregion maps and multivariate analyses such as nMDS and cluster analysis. We successfully detected spatial regimes and transitions in both terrestrial and aquatic systems using Fisher information. Furthermore, Fisher information provided explicit spatial information about community change that is absent from other multivariate approaches. Our results suggest that defining spatial regimes based on animal communities may better reflect ecological reality than do traditional ecoregion maps, especially in our current era of rapid and unpredictable ecological change. C1 [Sundstrom, Shana M.] Univ Nebraska Lincoln, Sch Nat Resources, 103 Hardin Hall,3310 Holdrege St, Lincoln, NE 68583 USA. [Eason, Tarsha; Garmestani, Ahjond S.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Nelson, R. John] Univ Victoria, Ctr Biomed Res, Dept Biol, Victoria, BC V8P 5C2, Canada. [Angeler, David G.] Swedish Univ Agr Sci, Dept Aquat Sci & Assessment, Box 7050, SE-75007 Uppsala, Sweden. [Barichievy, Chris] Zool Soc London, Regents Pk, London NW1 4RY, England. [Graham, Nicholas A. J.] Univ Lancaster, Lancaster Environm Ctr, Lancaster LA1 4YQ, England. [Granholm, Dean] US Fish & Wildlife Serv, Bloomington, MN 55437 USA. [Gunderson, Lance] Emory Univ, Dept Environm Sci, Atlanta, GA 30322 USA. [Knutson, Melinda] US Fish & Wildlife Serv, Reg 3, La Crosse, WI 54603 USA. [Nash, Kirsty L.] Univ Tasmania, Inst Marine & Antarct Studies, Ctr Marine Socioecol, Hobart, Tas 7000, Australia. [Spanbauer, Trisha] US EPA, Natl Res Council, Cincinnati, OH 45268 USA. [Stow, Craig A.] Great Lakes Environm Res Lab, Natl Oceanog & Atmospher Adm, Ann Arbor, MI 48108 USA. [Allen, Craig R.] Univ Nebraska, US Geol Survey, Nebraska Cooperat Fish & Wildlife Res Unit, Lincoln, NE 68583 USA. RP Sundstrom, SM (reprint author), Univ Nebraska Lincoln, Sch Nat Resources, 103 Hardin Hall,3310 Holdrege St, Lincoln, NE 68583 USA. EM sundstrom.shana@gmail.com FU USGS John Powell Center for Synthesis and Analysis; USGS National Climate Change and Wildlife Center; United States Geological Survey; Nebraska Game and Parks Commission; University of Nebraska-Lincoln; United States Fish and Wildlife Service; Wildlife Management Institute FX This research arose from a workshop series, 'Understanding and managing for resilience in the face of global change', which was funded by the USGS John Powell Center for Synthesis and Analysis, and the USGS National Climate Change and Wildlife Center. We thank the Powell Center for supporting collaborative and interdisciplinary research efforts. We thank JC Nelson at the USGS Upper Midwest Environmental Sciences Center for creating Fig. 1a. The Nebraska Cooperative Fish and Wildlife Research Unit is jointly supported by a cooperative agreement between the United States Geological Survey, the Nebraska Game and Parks Commission, the University of Nebraska-Lincoln, the United States Fish and Wildlife Service, and the Wildlife Management Institute. This is GLERL contribution number 1838. The views expressed in this article are those of the authors and do not necessarily represent the views or policies of the U.S. Environmental Protection Agency. NR 95 TC 0 Z9 0 U1 32 U2 32 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1461-023X EI 1461-0248 J9 ECOL LETT JI Ecol. Lett. PD JAN PY 2017 VL 20 IS 1 BP 19 EP 32 DI 10.1111/ele.12709 PG 14 WC Ecology SC Environmental Sciences & Ecology GA EF0OV UT WOS:000390026200002 PM 28000431 ER PT J AU Chaudhary, A Hantush, MM AF Chaudhary, Abhishek Hantush, Mohamed M. TI Bayesian Monte Carlo and maximum likelihood approach for uncertainty estimation and risk management: Application to lake oxygen recovery model SO WATER RESEARCH LA English DT Article DE Water quality; Environmental modeling; Risk management; Bayesian; Uncertainty estimation; Dissolved oxygen ID NONPOINT-SOURCE; WATER AB Model uncertainty estimation and risk assessment is essential to environmental management and informed decision making on pollution mitigation strategies. In this study, we apply a probabilistic methodology, which combines Bayesian Monte Carlo simulation and Maximum Likelihood estimation (BMCML) to calibrate a lake oxygen recovery model. We first derive an analytical solution of the differential equation governing lake-averaged oxygen dynamics as a function of time-variable wind speed. Statistical inferences on model parameters and predictive uncertainty are then drawn by Bayesian conditioning of the analytical solution on observed daily wind speed and oxygen concentration data obtained from an earlier study during two recovery periods on a eutrophic lake in upper state New York. The model is calibrated using oxygen recovery data for one year and statistical inferences were validated using recovery data for another year. Compared with essentially two-step, regression and optimization approach, the BMCML results are more comprehensive and performed relatively better in predicting the observed temporal dissolved oxygen levels (DO) in the lake. BMCML also produced comparable calibration and validation results with those obtained using popular Markov Chain Monte Carlo technique (MCMC) and is computationally simpler and easier to implement than the MCMC. Next, using the calibrated model, we derive an optimal relationship between liquid film-transfer coefficient for oxygen and wind speed and associated 95% confidence band, which are shown to be consistent with reported measured values at five different lakes. Finally, we illustrate the robustness of the BMCML to solve risk-based water quality management problems, showing that neglecting cross-correlations between parameters could lead to improper required BOD load reduction to achieve the compliance criteria of 5 mg/L. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Chaudhary, Abhishek] ETH, Inst Food Nutr & Hlth, CH-8092 Zurich, Switzerland. [Hantush, Mohamed M.] US EPA, ORD, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Chaudhary, A (reprint author), ETH, Inst Food Nutr & Hlth, CH-8092 Zurich, Switzerland. EM abhishek.chaudhary@hest.ethz.ch FU U.S. Environmental Protection Agency through its Office of Research and Development [EP-C-11-006]; Pegasus Technical Services, Inc. FX The U.S. Environmental Protection Agency through its Office of Research and Development partially funded and collaborated in the research described here under contract (EP-C-11-006) with Pegasus Technical Services, Inc. It has not been subject to the Agency review and therefore does not necessarily reflect the views of the Agency, and no official endorsement should be inferred. NR 31 TC 0 Z9 0 U1 5 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0043-1354 J9 WATER RES JI Water Res. PD JAN 1 PY 2017 VL 108 BP 301 EP 311 DI 10.1016/j.watres.2016.11.012 PG 11 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA EF2UR UT WOS:000390181600030 PM 27836170 ER PT J AU Belete, GF Voinov, A Laniak, GF AF Belete, Getachew F. Voinov, Alexey Laniak, Gerard F. TI An overview of the model integration process: From pre-integration assessment to testing SO ENVIRONMENTAL MODELLING & SOFTWARE LA English DT Review DE Integrated modeling; Interoperability; Interfaces; Wrapping; Components; Web services ID WEB-SERVICES; AGRICULTURAL SYSTEMS; LAND-USE; SIMULATION; FRAMEWORK; OPENMI; FUTURE; INTEROPERABILITY; INTERFACE; PLATFORM AB Integration of models requires linking models which can be developed using different tools, methodologies, and assumptions. We performed a literature review with the aim of improving our understanding of model integration process, and also presenting better strategies for building integrated modeling systems. We identified five different phases to characterize integration process: pre-integration assessment, preparation of models for integration, orchestration of models during simulation, data interoperability, and testing. Commonly, there is little reuse of existing frameworks beyond the development teams and not much sharing of science components across frameworks. We believe this must change to enable researchers and assessors to form complex workflows that leverage the current environmental science available. In this paper, we characterize the model integration process and compare integration practices of different groups. We highlight key strategies, features, standards, and practices that can be employed by developers to increase reuse and interoperability of science software components and systems. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Belete, Getachew F.; Voinov, Alexey] Univ Twente, ITC, NL-7500 AE Enschede, Netherlands. [Laniak, Gerard F.] US Environm Protect Agcy, Off Res & Dev, Washington, DC USA. RP Belete, GF (reprint author), Univ Twente, ITC, NL-7500 AE Enschede, Netherlands. EM getfeleke@gmail.com; aavoinov@gmail.com; laniak.gerry@epa.gov FU COMPLEX - Knowledge Based Climate Mitigation Systems for a Low Carbon Economy Project [EU-FP7-308601] FX G. F. Belete and A. Voinov were supported by COMPLEX - Knowledge Based Climate Mitigation Systems for a Low Carbon Economy Project, EU-FP7-308601. We are grateful to two anonymous reviewers for very useful comments. The authors thank Fran Rauschenberg of the US EPA for her valuable contributions. NR 82 TC 0 Z9 0 U1 2 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1364-8152 EI 1873-6726 J9 ENVIRON MODELL SOFTW JI Environ. Modell. Softw. PD JAN PY 2017 VL 87 BP 49 EP 63 DI 10.1016/j.envsoft.2016.10.013 PG 15 WC Computer Science, Interdisciplinary Applications; Engineering, Environmental; Environmental Sciences SC Computer Science; Engineering; Environmental Sciences & Ecology GA EE7HA UT WOS:000389785300005 ER PT J AU Nojavan, AF Qian, SS Stow, CA AF Nojavan, Farnaz A. Qian, Song S. Stow, Craig A. TI Comparative analysis of discretization methods in Bayesian networks SO ENVIRONMENTAL MODELLING & SOFTWARE LA English DT Article DE Bayesian networks; Discretization; Environmental modeling; Equal interval; Equal quantile; Moment matching ID BELIEF NETWORKS; RESOURCE-MANAGEMENT; LAKES; UNCERTAINTY; PREDICTION; NITROGEN; MODELS AB A key step in implementing Bayesian networks (BNs) is the discretization of continuous variables. There are several mathematical methods for constructing discrete distributions, the implications of which on the resulting model has not been discussed in literature. Discretization invariably results in loss of information, and both the discretization method and the number of intervals determines the level of such loss. We designed an experiment to evaluate the impact of commonly used discretization methods and number of intervals on the developed BNs. The conditional probability tables, model predictions, and management recommendations were compared and shown to be different among models. However, none of the models did uniformly well in all comparison criteria. As we cannot justify using one discretization method against others, we recommend caution when discretization is used, and a verification process that includes evaluating alternative methods to ensure that the conclusions are not an artifact of the discretization approach. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Nojavan, Farnaz A.] Duke Univ, Nichols Sch Environm, Durham, NC 27708 USA. [Nojavan, Farnaz A.] Atlantic Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Environm Protect Agcy, Narragansett, RI 02882 USA. [Qian, Song S.] Univ Toledo, Dept Environm Sci, Toledo, OH 43606 USA. [Stow, Craig A.] NOAA, Great Lakes Environm Res Lab, Ann Arbor, MI 48108 USA. RP Nojavan, AF (reprint author), Atlantic Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Environm Protect Agcy, Narragansett, RI 02882 USA. EM farnaz.nojavan@duke.edu OI Nojavan, Farnaz/0000-0002-6010-865X NR 38 TC 0 Z9 0 U1 2 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1364-8152 EI 1873-6726 J9 ENVIRON MODELL SOFTW JI Environ. Modell. Softw. PD JAN PY 2017 VL 87 BP 64 EP 71 DI 10.1016/j.envsoft.2016.10.007 PG 8 WC Computer Science, Interdisciplinary Applications; Engineering, Environmental; Environmental Sciences SC Computer Science; Engineering; Environmental Sciences & Ecology GA EE7HA UT WOS:000389785300006 ER PT J AU Sell, TK McGinty, EE Pollack, K Smith, KC Burke, TA Rutkow, L AF Sell, Tara Kirk McGinty, Emma E. Pollack, Keshia Smith, Katherine Clegg Burke, Thomas A. Rutkow, Lainie TI US State-Level Policy Responses to the Ebola Outbreak, 2014-2015 SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Article DE disease outbreaks; Ebola; hemorrhagic fever; public health; quarantine ID UNITED-STATES; PUBLIC-HEALTH; VIRUS DISEASE; QUARANTINE; EPIDEMIC AB Context: The 2014-2015 Ebola epidemic in West Africa raised concerns about the potential occurrence of an Ebola outbreak in the United States. The federal government and individual states developed guidance and policies to determine how to manage individuals within the United States who may have been exposed to Ebola. Design: A total of 139 documents describing state policies for individuals considered at risk for Ebola and the requirements, as well as restrictions these individuals may be subject to, were systematically identified and analyzed. Results: A wide range of policy responses and variations on quarantine, movement restrictions, exposure categories, and monitoring were found. While the majority of states reflected US Centers for Disease Control and Prevention guidance, some states enacted aggressive quarantine policies and movement restrictions, developed unique categorization strategies, and established more frequent monitoring procedures. Conclusions: Findings may help public health practitioners and policymakers anticipate what policies could be implemented in response to future infectious disease threats. Furthermore, practitioners and policymakers should assume that some variation in response policies will occur at the state level. C1 [Sell, Tara Kirk; McGinty, Emma E.; Pollack, Keshia; Rutkow, Lainie] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, Room 513,624 N Broadway, Baltimore, MD 21205 USA. [Smith, Katherine Clegg] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Behav & Soc, Baltimore, MD USA. [Sell, Tara Kirk] UPMC Ctr Hlth Secur, Baltimore, MD USA. [Burke, Thomas A.] US EPA, Washington, DC 20460 USA. RP Sell, TK (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, Room 513,624 N Broadway, Baltimore, MD 21205 USA. EM tsell1@jhu.edu FU Johns Hopkins Sommer Scholars Program FX Support for this research was provided to TKS by the Johns Hopkins Sommer Scholars Program. NR 19 TC 0 Z9 0 U1 10 U2 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1078-4659 EI 1550-5022 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD JAN-FEB PY 2017 VL 23 IS 1 BP 11 EP 19 DI 10.1097/PHH.0000000000000384 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA EE3BY UT WOS:000389462800007 PM 26672407 ER PT J AU McGinty, MD Burke, TA Resnick, B Barnett, DJ Smith, KC Rutkow, L AF McGinty, Meghan D. Burke, Thomas A. Resnick, Beth Barnett, Daniel J. Smith, Katherine C. Rutkow, Lainie TI Decision Processes and Determinants of Hospital Evacuation and Shelter-in-Place During Hurricane Sandy SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Article DE decision making; disasters; emergency preparedness; hospital evacuation; shelter-in-place ID EMERGENCY SITUATIONS; AFTERMATH; LESSONS AB Context: Evacuation and shelter-in-place decision making for hospitals is complex, and existing literature contains little information about how these decisions are made in practice. Objective: To describe decision-making processes and identify determinants of acute care hospital evacuation and shelter-in-place during Hurricane Sandy. Design: Semistructured interviews were conducted from March 2014 to February 2015 with key informants who had authority and responsibility for evacuation and shelter-in-place decisions for hospitals during Hurricane Sandy in 2012. Interviews were recorded, transcribed, and thematically analyzed. Setting and Participants: Interviewees included hospital executives and state and local public health, emergency management, and emergency medical service officials from Delaware, Maryland, New Jersey, and New York. Main Outcome Measure(s): Interviewees identified decision processes and determinants of acute care hospital evacuation and shelter-in-place during Hurricane Sandy. Results: We interviewed 42 individuals from 32 organizations. Decisions makers reported relying on their instincts rather than employing guides or tools to make evacuation and shelter-in-place decisions during Hurricane Sandy. Risk to patient health from evacuation, prior experience, cost, and ability to maintain continuity of operations were the most influential factors in decision making. Flooding and utility outages, which were predicted to or actually impacted continuity of operations, were the primary determinants of evacuation. Conclusion: Evacuation and shelter-in-place decision making for hospitals can be improved by ensuring hospital emergency plans address flooding and include explicit thresholds that, if exceeded, would trigger evacuation. Comparative risk assessments that inform decision making would be enhanced by improved collection, analysis, and communication of data on morbidity and mortality associated with evacuation versus sheltering-in-place of hospitals. In addition, administrators and public officials can improve their preparedness to make evacuation and shelter-in-place decisions by practicing the use of decision-making tools during training and exercises. C1 [McGinty, Meghan D.; Resnick, Beth; Rutkow, Lainie] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, 624 N Broadway Room 429, Baltimore, MD 21205 USA. [Barnett, Daniel J.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Environm Hlth Sci, Baltimore, MD USA. [Smith, Katherine C.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Behav & Soc, Baltimore, MD USA. [Burke, Thomas A.] US EPA, Washington, DC 20460 USA. RP McGinty, MD (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, 624 N Broadway Room 429, Baltimore, MD 21205 USA. EM meghan.mcginty@gmail.com FU Johns Hopkins Environment, Energy, Sustainability, and Health Institute (E2SHI) Fellowship; Lipitz Public Health Policy Award; National Institute for Occupational Safety and Health (NIOSH) Education and Research Center (ERC) for Occupational Safety and Health at the Johns Hopkins Bloomberg School of Public Health [T42-OH 008428]; Johns Hopkins Health Resources and Services Administration (HRSA) Trainee Fellowship Program [A03HP2750]; E2SHI Fellowship; John C. Hume Award; Victor Raymond Memorial Scholarship FX This research was supported by the 2013-2014 Johns Hopkins Environment, Energy, Sustainability, and Health Institute (E2SHI) Fellowship and the 2013-2014 Lipitz Public Health Policy Award. M.D.M. was supported in part by funding from the National Institute for Occupational Safety and Health (NIOSH) Education and Research Center (ERC) for Occupational Safety and Health at the Johns Hopkins Bloomberg School of Public Health (#T42-OH 008428); the 2015 Johns Hopkins Health Resources and Services Administration (HRSA) Trainee Fellowship Program Agreement (#A03HP2750); the 2013-2014 E2SHI Fellowship; the 2013-2014 John C. Hume Award; and the 2014-2015 Victor Raymond Memorial Scholarship. NR 28 TC 3 Z9 3 U1 5 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1078-4659 EI 1550-5022 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD JAN-FEB PY 2017 VL 23 IS 1 BP 29 EP 36 DI 10.1097/PHH.0000000000000404 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA EE3BY UT WOS:000389462800009 PM 26910873 ER PT J AU Koralegedara, NH Al-Abed, SR Rodrigo, SK Karna, RR Scheckel, KG Dionysiou, DD AF Koralegedara, Nadeesha H. Al-Abed, Souhail R. Rodrigo, Sanjeewa K. Karna, Ranju R. Scheckel, Kirk G. Dionysiou, Dionysios D. TI Alterations of lead speciation by sulfate from addition of flue gas desulfurization gypsum (FGDG) in two contaminated soils SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Flue gas desulfurization gypsum; Leaching test; Ferrihydrite bound Pb; Humic acid bound Pb leadhillite; Anglesite ID HUMIC SUBSTANCES; FLY-ASH; AQUEOUS-SOLUTIONS; METAL-IONS; PB; AVAILABILITY; FERRIHYDRITE; PHOSPHATE; IMMOBILIZATION; COPPER(II) AB This is the first study to evaluate the potential application of FGDG as an in situ Pb stabilizer in contaminated soils with two different compositions and to explain the underlying mechanisms. A smelter Pb contaminated soil (SM-soil), rich in ferrihydrite bound Pb (FH-Pb), cerussite and litharge with a total Pb content of 65,123 mg/kg and an organic matter rich orchard soil (BO-soil), rich in FH-Pb and humic acid bound Pb with a total Pb content of 1532 mg/kg were amended with 5% FGDG (w/w). We subjected the two soils to three leaching tests; toxicity characteristic leaching protocol (TCLP), synthetic precipitation leaching protocol (SPLP), kinetic batch leaching test (KBLT) and in-vitro bioaccessibility assay (IVBA) in order to evaluate the FGDG amendment on Pb stabilization. Solid residues of original and FGDG amended soil were analyzed using X-ray absorption spectroscopy (XAS) to identify changes in Pb speciation after each leaching test. The leachate Pb concentrations of FGDG amended soil were lower compared to those of in non-amended soil. The linear combination fitting analysis of XAS confirmed the formation of anglesite and leadhillite in FGDG amended soil. FGDG reduced the Pb desorption from ferrihydrite (FH), by forming FH-Pb-SO4 ternary complexes. FGDG decreased the Pb adsorption onto humic acid (HA) possibly due to the release of divalent cations such as Ca and Mg, which can compete with Pb to get adsorbed onto HA. The FGDG can successfully be used to remediate Pb contaminated soil. The efficiency of the treatment highly depends on the soil composition. Published by Elsevier B.V. C1 [Koralegedara, Nadeesha H.; Rodrigo, Sanjeewa K.] Pegasus Tech Serv Inc, 46 E Hollister St, Cincinnati, OH 45219 USA. [Al-Abed, Souhail R.; Scheckel, Kirk G.] US EPA, Natl Risk Management Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. [Karna, Ranju R.] Oak Ridge Natl Lab, Oak Ridge, TN 37831 USA. [Koralegedara, Nadeesha H.; Dionysiou, Dionysios D.] Univ Cincinnati, Engn Res Ctr 705, Dept Biomed Chem & Environm Engn, Environm Engn & Sci Program, Cincinnati, OH 45221 USA. RP Al-Abed, SR (reprint author), US EPA, Natl Risk Management Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM al-abed.souhail@epa.gov FU U.S. EPA National Risk Management Research Laboratory, Cincinnati, Ohio; DOE Office of Science [DE-AC02-06CH11357] FX This research was performed and funded by the U.S. EPA National Risk Management Research Laboratory, Cincinnati, Ohio. This paper has been subjected to the Agency's internal review and quality assurance approval. The views and conclusions presented herein do not reflect the views of the Agency or its policy. This research used resources of the Advanced Photon Source, a U.S. Department of Energy ( DOE) Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under Contract No. DE-AC02-06CH11357. The authors thank Dr. Raghuraman Venkatapathy for the valuable comments on the manuscript. NR 49 TC 0 Z9 0 U1 13 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD JAN 1 PY 2017 VL 575 BP 1522 EP 1529 DI 10.1016/j.scitotenv.2016.10.027 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA EF5MD UT WOS:000390373400153 PM 27743653 ER PT J AU Franson, R Scholes, C Krabbe, S AF Franson, Raymond Scholes, Chad Krabbe, Stephen TI Use of vegetation sampling and analysis to detect a problem within a portion of a prairie restoration project SO INTERNATIONAL JOURNAL OF PHYTOREMEDIATION LA English DT Article DE Vegetation analysis; vegetation sampling; land restoration; plant cover; prairie; success monitoring ID TALLGRASS PRAIRIE AB In June 2005, the Department of Energy (DOE) began establishing the 60-ha Howell Prairie around the disposal cell at the DOE Weldon Spring Site (WSS). Prairies were historically present in the area of the site. Quantitative Cover sampling was used to quantify Total Cover, Native Grass Cover, Non-Native Grass Cover, Native Forb Cover, Non-Native Forb Cover, Warm Season (C-4 Grass), Cool Season (C-3 Grass), Perennial Cover and Annual Cover, Litter, and Bare Ground. Four permanent vegetation sampling plots were established. The first 4 years of vegetation measurements at Howell Prairie were made during above-average rainfall years on burned and unburned plots. The fifth-year (2012) vegetation measurements were made after below-average rainfall. Five years of results not only document the consistency of the restoration effort in three areas, but also demonstrate deficiencies in Grass Cover in a fourth area. The results are not only useful for Howell Prairie, but will be useful for restoration work throughout the region. Restoration work suffers from a lack of success monitoring and in this case from a lack of available reference areas. Floristic Quality Indices are used to make qualitative comparisons of the site to Konza Prairie sites. C1 [Franson, Raymond; Krabbe, Stephen] Kansas City Reg Off, Missouri Dept Nat Resources, Lees Summit, MO USA. [Scholes, Chad] Rockhurst Univ, Kansas City, MO USA. [Krabbe, Stephen] Univ Missouri, Kansas City, MO 64110 USA. [Krabbe, Stephen] US EPA, Reg 7, Lenexa, KS USA. RP Franson, R (reprint author), Missouri Dept Nat Resources, 500 NE Colbern Rd, Lees Summit, MO 64086 USA. EM ozarksnatives@earthlink.net FU Weldon Spring Long-term Surveillance and Maintenance Project, DOE, Office of Legacy Management FX This research was funded by the Weldon Spring Long-term Surveillance and Maintenance Project, DOE, Office of Legacy Management. NR 25 TC 0 Z9 0 U1 7 U2 7 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1522-6514 EI 1549-7879 J9 INT J PHYTOREMEDIAT JI Int. J. Phytoremediat. PY 2017 VL 19 IS 1 BP 65 EP 72 DI 10.1080/15226514.2016.1216081 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA ED5TV UT WOS:000388916100008 PM 27552590 ER PT J AU Franson, R Krabbe, S Scholes, C AF Franson, Raymond Krabbe, Stephen Scholes, Chad TI Suppression of prairie grasses due to excess magnesium in a portion of a restored prairie SO INTERNATIONAL JOURNAL OF PHYTOREMEDIATION LA English DT Article DE Magnesium-to-potassium ratio; magnesium toxicity; prairie success; restoration ID KAOLINITE-SMECTITE; INTERSTRATIFICATION AB In June 2002, the Department of Energy (DOE) began establishing the 60 ha Howell Prairie at the DOE Weldon Spring Site (WSS). In one area, the clay base is different from the other soil (subarea 2C). Vegetation sampling was conducted on four permanent plots across the prairie beginning in 2008, and shows that three of the four plots have strong establishment of native prairie species including prairie grasses. The fourth plot (subarea 2C), where the soil is different, shows significantly less native grass cover and stunted vegetation compared to the other three plots. One hundred twenty-five soil samples were taken in 6 different months and in 6 different years across the entire prairie restoration. Across the prairie, potassium (K) and phosphorus (P) were not limiting. The pH, organic matter content (OM), and cation exchange capacity (CEC) did not show trends related to the vegetation issues in subarea 2C. Ordination of the ratio of magnesium (Mg):K shows that Mg is very high in subarea 2C, which has been demonstrated to suppress the growth of prairie grasses. Subarea 2C contains interstratified kaolinite-smectite clay which contributes Mg to soil. It is hypothesized that an inexpensive, nondestructive treatment (addition of K) could be applied to remediate this area. C1 [Franson, Raymond; Krabbe, Stephen] Kansas City Reg Off, Missouri Dept Nat Resources, Lees Summit, MO USA. [Krabbe, Stephen] Univ Missouri, Kansas City, MO 64110 USA. [Scholes, Chad] Rockhurst Univ, Kansas City, MO USA. [Krabbe, Stephen] US EPA, Reg 7, Lenexa, KS USA. RP Franson, R (reprint author), Missouri Dept Nat Resources, 500 NE Colbern Rd, Jefferson City, MO 65102 USA. EM ozarksnatives@earthlink.net FU Weldon Spring Long-term Surveillance and Maintenance Project, Department of Energy, Office of Legacy Management FX This research was funded by the Weldon Spring Long-term Surveillance and Maintenance Project, Department of Energy, Office of Legacy Management. NR 22 TC 0 Z9 0 U1 5 U2 5 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1522-6514 EI 1549-7879 J9 INT J PHYTOREMEDIAT JI Int. J. Phytoremediat. PY 2017 VL 19 IS 1 BP 73 EP 79 DI 10.1080/15226514.2016.1216082 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA ED5TV UT WOS:000388916100009 PM 27552477 ER PT J AU Fitzpatrick, JM Roberts, DW Patlewicz, G AF Fitzpatrick, Jeremy M. Roberts, David W. Patlewicz, Grace TI What determines skin sensitization potency: Myths, maybes and realities. The 500 molecular weight cut-off: An updated analysis SO JOURNAL OF APPLIED TOXICOLOGY LA English DT Article DE skin penetration; molecular weight; Local lymph node assay (LLNA); Guinea pig maximization test (GPMT); Registration; Evaluation; Authorization and restriction of CHemicals (REACH); reaction chemistry mechanistic domains ID LYMPH-NODE ASSAY; APPLICABILITY DOMAIN CLASSIFICATION; CONTACT-DERMATITIS; GUINEA-PIG; TIMES-SS; ABSORPTION; HYPERSENSITIVITY; IDENTIFICATION; COMPILATION; PENETRATION AB It is widely accepted that substances must have a molecular weight (MW)<500 to penetrate effectively through the skin to induce sensitization. Roberts et al. (2012. Contact Dermatitis 68: 32-41) evaluated a data set of 699 substances taken from the TIMES-SS expert system and identified that of the 13 substances with a MW>500, five were sensitizers. This provided good evidence to refute such a MW 500 threshold. While Roberts et al. (2012) made a convincing case that the MW>500 cut-off was not a true requirement for sensitization, the number of counter examples identified were too few to draw any statistical conclusions. This updated analysis systematically interrogated a large repository of sensitization information collected under the EU REACH regulation. A data set of 2904 substances that had been tested for skin sensitization, using guinea pigs and/or mice were collected. The data set contained 197 substances with a MW>500; 33 of these were skin sensitizers. Metal containing complexes, reaction products and mixtures were excluded from further consideration. The final set of 14 sensitizers substantiated the original findings. The study also assessed whether the same reaction chemistry principles established for low MW sensitizers applied to chemicals with a MW>500. The existing reaction chemistry considerations were found appropriate to rationalize the sensitization behaviour of the 14 sensitizers with a MW>500. The existence of the MW 500 threshold, based on the widespread misconception that the ability to penetrate efficiently the stratum corneum is a key determinant of skin sensitization potential and potency, was refuted. Copyright (c) 2016 John Wiley & Sons, Ltd. C1 [Fitzpatrick, Jeremy M.; Patlewicz, Grace] US EPA, NCCT, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. [Roberts, David W.] Liverpool John Moores Univ, Sch Pharm, Liverpool, Merseyside, England. RP Patlewicz, G (reprint author), US EPA, NCCT, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM gpatlewicz@gmail.com OI Patlewicz, Grace/0000-0003-3863-9689 NR 46 TC 0 Z9 0 U1 8 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0260-437X EI 1099-1263 J9 J APPL TOXICOL JI J. Appl. Toxicol. PD JAN PY 2017 VL 37 IS 1 BP 105 EP 116 DI 10.1002/jat.3348 PG 12 WC Toxicology SC Toxicology GA EC7DF UT WOS:000388295300010 PM 27283458 ER PT J AU Fitzpatrick, JM Roberts, DW Patlewicz, G AF Fitzpatrick, Jeremy M. Roberts, David W. Patlewicz, Grace TI Is skin penetration a determining factor in skin sensitization potential and potency? Refuting the notion of a LogKow threshold for skin sensitization SO JOURNAL OF APPLIED TOXICOLOGY LA English DT Article DE skin penetration; LogKow; molecular weight; Local Lymph Node Assay (LLNA); Guinea Pig Maximization Test (GPMT); Registration; Evaluation; Authorization and restriction of CHemicals (REACH) ID LYMPH-NODE ASSAY; APPLICABILITY DOMAIN CLASSIFICATION; NONANIMAL-BASED PREDICTION; TOXICOLOGICAL END-POINTS; PERMEABILITY; COMPILATION; CHEMISTRY; CHEMICALS; MOUSE; MODEL AB It is widely accepted that substances that cannot penetrate through the skin will not be sensitizers. LogKow and molecular weight (MW) have been used to set thresholds for sensitization potential. Highly hydrophilic substances e.g. LogKow 1 are expected not to penetrate effectively to induce sensitization. To investigate whether LogKow >1 is a true requirement for sensitization, a large dataset of substances that had been evaluated for their skin sensitization potential under Registration, Evaluation, Authorisation and restriction of CHemicals (REACH), together with available measured LogKow values was compiled using the OECD eChemPortal. The incidence of sensitizers relative to non-sensitizers above and below a LogKow of 1 was explored. Reaction chemistry principles were used to explain the sensitization observed for the subset of substances with a LogKow 0. 1482 substances were identified with skin sensitization data and measured LogKow values. 525 substances had a measured LogKow 1, 100 of those were sensitizers. There was no significant difference in the incidence of sensitizers above and below a LogKow of 1. Reaction chemistry principles that had been established for lower MW and more hydrophobic substances were found to be still valid in rationalizing the skin sensitizers with a LogKow 0. The LogKow threshold arises from the widespread misconception that the ability to efficiently penetrate the stratum corneum is a key determinant of sensitization potential and potency. Copyright (c) 2016 John Wiley & Sons, Ltd. C1 [Fitzpatrick, Jeremy M.; Patlewicz, Grace] US EPA, NCCT, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. [Roberts, David W.] Liverpool John Moores Univ, Sch Pharm & Chem, Liverpool L3 3AF, Merseyside, England. RP Patlewicz, G (reprint author), US EPA, NCCT, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM gpatlewicz@gmail.com NR 35 TC 0 Z9 0 U1 5 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0260-437X EI 1099-1263 J9 J APPL TOXICOL JI J. Appl. Toxicol. PD JAN PY 2017 VL 37 IS 1 BP 117 EP 127 DI 10.1002/jat.3354 PG 11 WC Toxicology SC Toxicology GA EC7DF UT WOS:000388295300011 PM 27357739 ER PT J AU Zoogman, P Liu, X Suleiman, RM Pennington, WF Flittner, DE Al-Saadi, JA Hilton, BB Nicks, DK Newchurch, MJ Carr, JL Janz, SJ Andraschko, MR Arola, A Baker, BD Canova, BP Miller, CC Cohen, RC Davis, JE Dussault, ME Edwards, DP Fishman, J Ghulam, A Abad, GG Grutter, M Herman, JR Houck, J Jacob, DJ Joiner, J Kerridge, BJ Kim, J Krotkov, NA Lamsal, L Li, C Lindfors, A Martin, RV McElroy, CT McLinden, C Natraj, V Neil, DO Nowlan, CR O'Sullivan, EJ Palmer, PI Pierce, RB Pippin, MR Saiz-Lopez, A Spurr, RJD Szykman, JJ Torres, O Veefkind, JP Veihelmann, B Wang, H Wang, J Chance, K AF Zoogman, P. Liu, X. Suleiman, R. M. Pennington, W. F. Flittner, D. E. Al-Saadi, J. A. Hilton, B. B. Nicks, D. K. Newchurch, M. J. Carr, J. L. Janz, S. J. Andraschko, M. R. Arola, A. Baker, B. D. Canova, B. P. Miller, C. Chan Cohen, R. C. Davis, J. E. Dussault, M. E. Edwards, D. P. Fishman, J. Ghulam, A. Abad, G. Gonzalez Grutter, M. Herman, J. R. Houck, J. Jacob, D. J. Joiner, J. Kerridge, B. J. Kim, J. Krotkov, N. A. Lamsal, L. Li, C. Lindfors, A. Martin, R. V. McElroy, C. T. McLinden, C. Natraj, V. Neil, D. O. Nowlan, C. R. O'Sullivan, E. J. Palmer, P. I. Pierce, R. B. Pippin, M. R. Saiz-Lopez, A. Spurr, R. J. D. Szykman, J. J. Torres, O. Veefkind, J. P. Veihelmann, B. Wang, H. Wang, J. Chance, K. TI Tropospheric emissions: Monitoring of pollution (TEMPO) SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article ID ROTATIONAL RAMAN-SCATTERING; BACKSCATTER ULTRAVIOLET MEASUREMENTS; OZONE PROFILE RETRIEVALS; SURFACE UV IRRADIANCE; SATELLITE-OBSERVATIONS; AIR-QUALITY; NO2 RETRIEVAL; FORMALDEHYDE COLUMNS; GLOBAL OBSERVATIONS; NORTH-AMERICA AB TEMPO was selected in 2012 by NASA as the first Earth Venture Instrument, for launch between 2018 and 2021. It will measure atmospheric pollution for greater North America from space using ultraviolet and visible spectroscopy. TEMPO observes from Mexico City, Cuba, and the Bahamas to the Canadian oil sands, and from the Atlantic to the Pacific, hourly and at high spatial resolution (similar to 2.1 km N/S x 4.4 km E/W at 36.5 degrees N, 100 degrees W). TEMPO provides a tropospheric measurement suite that includes the key elements of tropospheric air pollution chemistry, as well as contributing to carbon cycle knowledge. Measurements are made hourly from geostationary (GEO) orbit, to capture the high variability present in the diurnal cycle of emissions and chemistry that are unobservable from current low-Earth orbit (LEO) satellites that measure once per day. The small product spatial footprint resolves pollution sources at sub-urban scale. Together, this temporal and spatial resolution improves emission inventories, monitors population exposure, and enables effective emission-control strategies. TEMPO takes advantage of a commercial GEO host spacecraft to provide a modest cost mission that measures the spectra required to retrieve ozone (O-3), nitrogen dioxide (NO2), sulfur dioxide (SO2), formaldehyde (H2CO), glyoxal (C2H2O2), bromine monoxide (BrO), IO (iodine monoxide), water vapor, aerosols, cloud parameters, ultraviolet radiation, and foliage properties. TEMPO thus measures the major elements, directly or by proxy, in the tropospheric O-3 chemistry cycle. Multi-spectral observations provide sensitivity to O-3 in the lowermost troposphere, substantially reducing uncertainty in air quality predictions. TEMPO quantifies and tracks the evolution of aerosol loading. It provides these near-realtime air quality products that will be made publicly available. TEMPO will launch at a prime time to be the North American component of the global geostationary constellation of pollution monitoring together with the European Sentinel-4 (S4) and Korean Geostationary Environment Monitoring Spectrometer (GEMS) instruments. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Zoogman, P.; Liu, X.; Suleiman, R. M.; Davis, J. E.; Dussault, M. E.; Abad, G. Gonzalez; Houck, J.; Martin, R. V.; Nowlan, C. R.; O'Sullivan, E. J.; Wang, H.; Chance, K.] Harvard Smithsonian Ctr Astrophys, Cambridge, MA 02138 USA. [Pennington, W. F.; Flittner, D. E.; Al-Saadi, J. A.; Hilton, B. B.; Andraschko, M. R.; Neil, D. O.; Pippin, M. R.] NASA, Langley Res Ctr, Hampton, VA USA. [Nicks, D. K.; Baker, B. D.; Canova, B. P.] Ball Aerosp & Technol Corp, Boulder, CO USA. [Newchurch, M. J.] Univ Alabama, Huntsville, AL USA. [Carr, J. L.] Carr Astronaut, Greenbelt, MD USA. [Janz, S. J.; Joiner, J.; Krotkov, N. A.; Lamsal, L.; Torres, O.] NASA, Goddard Space Flight Ctr, Greenbelt, MD USA. [Arola, A.; Lindfors, A.] Finnish Meteorol Inst, Helsinki, Finland. [Miller, C. Chan; Jacob, D. J.] Harvard Univ, Cambridge, MA 02138 USA. [Cohen, R. C.] Univ Calif Berkeley, Berkeley, CA 94720 USA. [Edwards, D. P.] Natl Ctr Atmospher Res, Boulder, CO USA. [Fishman, J.; Ghulam, A.] St Louis Univ, St Louis, MO 63103 USA. [Grutter, M.] Univ Nacl Autonoma Mexico, Mexico City 04510, DF, Mexico. [Herman, J. R.] Univ Maryland Baltimore Cty, Baltimore, MD 21228 USA. [Kerridge, B. J.] Rutherford Appleton Lab, Chilton, Oxon, England. [Kim, J.] Yonsei Univ, Seoul 120749, South Korea. [Lamsal, L.] Univ Space Res Assoc, GESTAR, Greenbelt, MD USA. [Martin, R. V.] Dalhousie Univ, Halifax, NS B3H 3J5, Canada. [McElroy, C. T.] York Univ, N York, ON M3J 1P3, Canada. [McLinden, C.] Environm & Climate Change Canada, Gatineau, PQ, Canada. [Natraj, V.] NASA, Jet Prop Lab, Pasadena, CA USA. [Palmer, P. I.] Univ Edinburgh, Edinburgh EH8 9YL, Midlothian, Scotland. [Pierce, R. B.] NOAA, Silver Spring, MD USA. [Saiz-Lopez, A.] CSIC, Inst Quim Fis Rocasolano, Madrid, Spain. [Spurr, R. J. D.] RT Solut Inc, Cambridge, MA USA. [Szykman, J. J.] US EPA, Washington, DC USA. [Veefkind, J. P.] Koninklijk Nederlands Meteorolog Inst, De Bilt, Netherlands. [Veihelmann, B.] European Space Agcy, F-75738 Paris 15, France. [Wang, J.] Univ Nebraska, Lincoln, NE 68583 USA. RP Zoogman, P (reprint author), Harvard Smithsonian Ctr Astrophys, Cambridge, MA 02138 USA. RI Cohen, Ronald/A-8842-2011; Saiz-Lopez, Alfonso/B-3759-2015; Lindfors, Anders/C-6727-2012; Wang, Jun/A-2977-2008; OI Cohen, Ronald/0000-0001-6617-7691; Saiz-Lopez, Alfonso/0000-0002-0060-1581; Wang, Jun/0000-0002-7334-0490; Gonzalez Abad, Gonzalo/0000-0002-8090-6480; Arola, Antti/0000-0002-9220-0194 NR 129 TC 4 Z9 4 U1 27 U2 27 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 EI 1879-1352 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD JAN PY 2017 VL 186 SI SI BP 17 EP 39 DI 10.1016/j.jqsrt.2016.05.008 PG 23 WC Optics; Spectroscopy SC Optics; Spectroscopy GA ED7BP UT WOS:000389011000003 ER PT J AU Ranatunga, T Tong, STY Yang, YJ AF Ranatunga, Thushara Tong, Susanna T. Y. Yang, Y. Jeffrey TI An approach to measure parameter sensitivity in watershed hydrological modelling SO HYDROLOGICAL SCIENCES JOURNAL-JOURNAL DES SCIENCES HYDROLOGIQUES LA English DT Article DE Sensitivity analysis; HSPF; NRMSE; flow duration curve; model development; model calibration ID LAS-VEGAS WASH; UNCERTAINTY; RUNOFF; HSPF; SWAT; IDENTIFIABILITY; MANAGEMENT; NEVADA; CALIBRATION; PREDICTION AB Hydrological responses vary spatially and temporally according to watershed characteristics. In this study, the hydrological models that we developed earlier for the Little Miami River (LMR) and Las Vegas Wash (LVW) watersheds in the USA were used for detailed sensitivity analyses. To compare the relative sensitivities of the hydrological parameters of these two models, we used normalized root mean square error (NRMSE). By combining the NRMSE index with the flow duration curve analysis, we derived an approach to measure parameter sensitivities under different flow regimes. Results show that the parameters related to groundwater are highly sensitive in the LMR watershed, whereas the LVW watershed is primarily sensitive to near-surface and impervious parameters. The high and medium flows are more impacted by most of the parameters. The low flow regime was highly sensitive to groundwater-related parameters. Moreover, our approach is found to be useful in facilitating model development and calibration. C1 [Ranatunga, Thushara; Tong, Susanna T. Y.] Univ Cincinnati, Dept Geog, Cincinnati, OH 45220 USA. [Yang, Y. Jeffrey] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Tong, STY (reprint author), Univ Cincinnati, Dept Geog, Cincinnati, OH 45220 USA. EM susanna.tong@uc.edu FU U.S. Environmental Protection Agency [EP-C-11-006] FX This work is partially supported by the U.S. Environmental Protection Agency [grant number: EP-C-11-006]. NR 52 TC 0 Z9 0 U1 10 U2 10 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 0262-6667 EI 2150-3435 J9 HYDROLOG SCI J JI Hydrol. Sci. J.-J. Sci. Hydrol. PD JAN PY 2017 VL 62 IS 1 BP 76 EP 92 DI 10.1080/02626667.2016.1174335 PG 17 WC Water Resources SC Water Resources GA ED1PG UT WOS:000388616800007 ER PT J AU Huang, L Ernstoff, A Fantke, P Csiszar, SA Jolliet, O AF Huang, Lei Ernstoff, Alexi Fantke, Peter Csiszar, Susan A. Jolliet, Olivier TI A review of models for near-field exposure pathways of chemicals in consumer products SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Review DE Human exposure models; High-throughput risk screening; Life cycle impact assessment; Mass transfer fractions; Consumer products; Indoor environment ID SEMIVOLATILE ORGANIC-COMPOUNDS; DRY BUILDING-MATERIALS; MASS-TRANSFER MODEL; NONDIETARY INGESTION EXPOSURE; PREDICTING SKIN PERMEABILITY; POLYVINYL-CHLORIDE PRODUCTS; CYCLE IMPACT ASSESSMENT; PERSONAL CARE PRODUCTS; AIR-POLLUTANT EXPOSURE; IN-VITRO BIOACTIVITY AB Exposure to chemicals in consumer products has been gaining increasing attention, with multiple studies showing that near-field exposures from products is high compared to far-field exposures. Regarding the numerous chemical-product combinations, there is a need for an overarching review of models able to quantify the multiple transfers of chemicals from products used near-field to humans. The present review therefore aims at an in-depth overview of modeling approaches for near-field chemical release and human exposure pathways associated with consumer products. It focuses on lower-tier, mechanistic models suitable for life cycle assessments (LCA), chemical alternative assessment (CAA) and high-throughput screening risk assessment (HTS). Chemicals in a product enter the near-field via a defined "compartment of entry", are transformed or transferred to adjacent compartments, and eventually end in a "human receptor compartment". We first focus on models of physical mass transfers from the product to 'near-field' compartments. For transfers of chemicals from article interior, adequate modeling of in-article diffusion and of partitioning between article surface and air/skin/food is key. Modeling volatilization and subsequent transfer to the outdoor is crucial for transfers of chemicals used in the inner space of appliances, on object surfaces or directly emitted to indoor air. For transfers from skin surface, models need to reflect the competition between dermal permeation, volatilization and fraction washed-off. We then focus on transfers from the 'near-field' to 'human' compartments, defined as respiratory tract, gastrointestinal tract and epidermis, for which good estimates of air concentrations, non-dietary ingestion parameters and skin permeation are essential, respectively. We critically characterize for each exposure pathway the ability of models to estimate near-field transfers and to best inform LCA, CAA and HTS, summarizing the main characteristics of the potentially best-suited models. This review identifies large knowledge gaps for several near-field pathways and suggests research needs and future directions. (C) 2016 Elsevier B.V. All rights reserved. C1 [Huang, Lei; Jolliet, Olivier] Univ Michigan, Sch Publ Hlth, Environm Hlth Sci & Risk Sci Ctr, Ann Arbor, MI 48109 USA. [Ernstoff, Alexi; Fantke, Peter] Tech Univ Denmark, Quantitat Sustainabil Assessment Div, Dept Engn Management, DK-2808 Lyngby, Denmark. [Csiszar, Susan A.] US EPA, Oak Ridge Inst Sci & Educ Res Participant, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Huang, L (reprint author), Univ Michigan, Sch Publ Hlth, Environm Hlth Sci & Risk Sci Ctr, Ann Arbor, MI 48109 USA. EM huanglei@umich.edu OI Fantke, Peter/0000-0001-7148-6982; Ernstoff, Alexi/0000-0002-1114-6596 FU US EPA [EP-14-C-000115]; Marie Curie project Quan-Tox - European Commission under the Seventh Framework Programme [631910]; U.S. Department of Energy [DW-89-92298301]; U.S. Environmental Protection Agency [DW-89-92298301] FX Funding for this research was provided by US EPA contract EP-14-C-000115 on Development of Modular Risk Pathway Descriptions for Life Cycle Assessment and by the Marie Curie project Quan-Tox (grant agreement no. 631910) funded by the European Commission under the Seventh Framework Programme. This research was supported in part by an appointment of S. Csiszar to the Postdoctoral Research Program at the National Risk Management Research Laboratory, U.S. EPA administered by the Oak Ridge Institute for Science and Education through Interagency Agreement No. DW-89-92298301 between the U.S. Department of Energy and the U.S. Environmental Protection Agency. NR 182 TC 1 Z9 1 U1 18 U2 18 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD JAN 1 PY 2017 VL 574 BP 1182 EP 1208 DI 10.1016/j.scitotenv.2016.06.118 PG 27 WC Environmental Sciences SC Environmental Sciences & Ecology GA ED7ZA UT WOS:000389090100110 PM 27644856 ER PT J AU Yost, EE Stanek, J Burgoon, LD AF Yost, Erin E. Stanek, John Burgoon, Lyle D. TI A decision analysis framework for estimating the potential hazards for drinking water resources of chemicals used in hydraulic fracturing fluids SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Hydraulic fracturing; Hazard evaluation; Exposure assessment ID NATURAL-GAS EXTRACTION; ORGANIC-COMPOUNDS; MARCELLUS SHALE; GROUNDWATER; OPERATIONS; FIELD AB Despite growing concerns over the potential for hydraulic fracturing to impact drinking water resources, there are limited data available to identify chemicals used in hydraulic fracturing fluids that may pose public health concerns. In an effort to explore these potential hazards, a multi-criteria decision analysis (MCDA) framework was employed to analyze and rank selected subsets of these chemicals by integrating data on toxicity, frequency of use, and physicochemical properties that describe transport in water. Data used in this analysis were obtained from publicly available databases compiled by the United States Environmental Protection Agency (EPA) as part of a larger study on the potential impacts of hydraulic fracturing on drinldng water. Starting with nationwide hydraulic fracturing chemical usage data from EPA's analysis of the FracFocus Chemical Disclosure Registry 1.0, MCDAs were performed on chemicals that had either noncancer toxicity values (n = 37) or cancer-specific toxicity values (n = 10). The noncancer MCDA was then repeated for subsets of chemicals reported in three representative states (Texas, n = 31; Pennsylvania, n = 18; and North Dakota, n = 20). Within each MCDA, chemicals received scores based on relative toxicity, relative frequency of use, and physicochemical properties (mobility in water, volatility, persistence). Results show a relative ranking of these chemicals based on hazard potential, and provide preliminary insight into chemicals that may be more likely than others to impact drinking water resources. Comparison of nationwide versus state-specific analyses indicates regional differences in the chemicals that may be of more concern to drinking water resource, although many chemicals were commonly used and received similar overall hazard rankings. Several chemicals highlighted by these MCDAs have been reported in groundwater near areas of hydraulic fracturing activity. This approach is intended as a preliminary analysis, and represents one possible method for integrating data to explore potential public health impacts. Published by Elsevier B.V. C1 [Yost, Erin E.; Stanek, John; Burgoon, Lyle D.] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA. [Burgoon, Lyle D.] US Army Engn Res & Dev Ctr, Environm Lab, Res Triangle Pk, NC USA. RP Burgoon, LD (reprint author), US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA.; Burgoon, LD (reprint author), US Army Engn Res & Dev Ctr, Environm Lab, Res Triangle Pk, NC USA. EM Lyle.D.Burgoon@usace.army.mil OI Burgoon, Lyle/0000-0003-4977-5352 NR 40 TC 0 Z9 0 U1 31 U2 31 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD JAN 1 PY 2017 VL 574 BP 1544 EP 1558 DI 10.1016/j.scitotenv.2016.08.167 PG 15 WC Environmental Sciences SC Environmental Sciences & Ecology GA ED7ZA UT WOS:000389090100145 PM 27666475 ER PT J AU Buck, KD AF Buck, Kyle D. TI A Proposed Method for Spatial Data Disaggregation and Interpolation SO PROFESSIONAL GEOGRAPHER LA English DT Article DE data interpolation; Florida; nested geographies; principal components analysis; scaling ID SOCIAL VULNERABILITY; US CITIES; MANAGEMENT; GROWTH; SEGREGATION; INDICATORS; FRAMEWORK; INDEX AB The Model for External Reliance of Localities in (MERLIN) Coastal Management Zones is a proposed solution to allow scaling of variables to smaller, nested geographies. Using a principal components analysis and data normalization techniques, smaller scale data relationships are linked to data relationships within larger geographies and scaling factors are developed for each. In using these relationships, MERLIN will derive a set of variables scaled to a desired geography representing the attributes of the population present. The concept driving MERLIN's development is that correlations between variables at a specific location and level of geography can be tested and applied to other scales for interpolations. This flexibility and relative simplicity of calculation make MERLIN a valuable tool in many types of social research and for data interpolation. In a pilot study, the MERLIN model is applied to counties along the Gulf Coast of Florida to create a well-being index at the census tract level. Results reveal a landscape that better accounts for the localized patterns of values situated within a larger geographic unit. C1 [Buck, Kyle D.] US EPA, ORD, NHEERL, Gulf Ecol Div, Gulf Breeze, FL 32561 USA. RP Buck, KD (reprint author), US EPA, ORD, NHEERL, Gulf Ecol Div, Gulf Breeze, FL 32561 USA. EM kdbuck4@gmail.com FU National Oceanic and Atmospheric Administration FX The information in this document has been funded wholly (or in part) by the National Oceanic and Atmospheric Administration. It has been subjected to review by the National Centers for Coastal Ocean Science and approved for publication. Approval does not signify that the contents reflect the views of the Administration, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 33 TC 0 Z9 0 U1 9 U2 9 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0033-0124 EI 1467-9272 J9 PROF GEOGR JI Prof. Geogr. PY 2017 VL 69 IS 1 BP 70 EP 79 DI 10.1080/00330124.2016.1158116 PG 10 WC Geography SC Geography GA EC3LI UT WOS:000388027200007 ER PT J AU Pan, Z Zhao, L Boufadel, MC King, T Robinson, B Conmy, R Lee, K AF Pan, Zhong Zhao, Lin Boufadel, Michel C. King, Thomas Robinson, Brian Conmy, Robyn Lee, Kenneth TI Impact of mixing time and energy on the dispersion effectiveness and droplets size of oil SO CHEMOSPHERE LA English DT Article DE Dispersion effectiveness; Droplet size distribution; Mixing time; Mixing energy; Viscosity ID CRUDE-OIL; EFFECTIVENESS PROTOCOL; CHEMICAL DISPERSION; INTERFACIAL-TENSION; BREAKING WAVES; SPILL; TANK; BIODEGRADATION; SIMULATION; VISCOSITY AB The effects of mixing time and energy on Alaska Northern Slope (ANS) and diluted bitumen Cold Lake Blend (CLB) were investigated using EPA baffled flask test. Dispersion effectiveness and droplet size distribution were measured after 5-120 min. A modeling method to predict the mean droplet size was introduced for the first time to tentatively elucidate the droplet size breakup mechanism. The ANS dispersion effectiveness greatly increased with dispersant and mixing energy. However, little CLB dispersion was noted at small energy input (epsilon = 0.02 Watt/kg). With dispersant, the ANS droplet size distribution reached quasi-equilibrium within 10 min, but that of CLB seems to reach quasi-equilibrium after 120 min. Dispersants are assumed ineffective on high viscosity oils because dispersants do not penetrate them. We provide an alternative explanation based on the elongation time of the droplets and its residence in high intensity zones. When mixing energy is small, CLB did not disperse after 120 min, long enough to allow the surfactant penetration. Our findings suggest that dispersants may disperse high viscosity oils at a rougher sea state and a longer time. The latter could determine how far offshore one can intervene for effective responses to a high viscosity oil spill offshore. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Pan, Zhong; Zhao, Lin; Boufadel, Michel C.] New Jersey Inst Technol, Ctr Nat Resources Dev & Protect, Dept Civil & Environm Engn, Newark, NJ 07102 USA. [King, Thomas; Robinson, Brian] Bedford Inst Oceanog, Ctr Offshore Oil Gas & Energy Res, Dept Fisheries & Oceans Canada, Dartmouth, NS B2Y 4A2, Canada. [Conmy, Robyn] US EPA, Natl Risk Management Res Lab, Off Res & Dev, 26 West Martin Luther King Blvd, Cincinnati, OH 45268 USA. [Lee, Kenneth] Australian Resources Res Ctr, CSIRO, Wealth Oceans Natl Res Flagship, Kensington, NSW, Australia. RP Boufadel, MC (reprint author), New Jersey Inst Technol, Ctr Nat Resources Dev & Protect, Dept Civil & Environm Engn, Newark, NJ 07102 USA. EM boufadel@gmail.com FU Department of Fisheries and Ocean Canada (DFO) [F5211-130060] FX This research was made possible by a grant from the Department of Fisheries and Ocean Canada (DFO), Contract No. F5211-130060. However, no endorsement of the sponsor is implied. NR 54 TC 0 Z9 0 U1 112 U2 112 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD JAN PY 2017 VL 166 BP 246 EP 254 DI 10.1016/j.chemosphere.2016.09.052 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA DZ9HR UT WOS:000386186400027 PM 27700991 ER PT J AU Dively, GP Venugopal, PD Finkenbinder, C AF Dively, Galen P. Venugopal, P. Dilip Finkenbinder, Chad TI Field-Evolved Resistance in Corn Earworm to Cry Proteins Expressed by Transgenic Sweet Corn SO PLOS ONE LA English DT Article ID HELICOVERPA-ZEA LEPIDOPTERA; BACILLUS-THURINGIENSIS TOXINS; FALL ARMYWORM LEPIDOPTERA; BASE-LINE SUSCEPTIBILITY; INSECT RESISTANCE; SPODOPTERA-FRUGIPERDA; BT MAIZE; CROSS-RESISTANCE; BORER LEPIDOPTERA; COTTON BOLLWORM AB Background Transgenic corn engineered with genes expressing insecticidal toxins from the bacterium Bacillus thuringiensis (Berliner) (Bt) are now a major tool in insect pest management. With its widespread use, insect resistance is a major threat to the sustainability of the Bt transgenic technology. For all Bt corn expressing Cry toxins, the high dose requirement for resistance management is not achieved for corn earworm, Helicoverpa zea (Boddie), which is more tolerant to the Bt toxins. Methodology/Major Findings We present field monitoring data using Cry1Ab (1996-2016) and Cry1A.105+Cry2Ab2 (2010-2016) expressing sweet corn hybrids as in-field screens to measure changes in field efficacy and Cry toxin susceptibility to H. zea. Larvae successfully damaged an increasing proportion of ears, consumed more kernel area, and reached later developmental stages (4th - 6th instars) in both types of Bt hybrids (Cry1Ab-event Bt11, and Cry1A.105+Cry2Ab2-event MON89034) since their commercial introduction. Yearly patterns of H. zea population abundance were unrelated to reductions in control efficacy. There was no evidence of field efficacy or tissue toxicity differences among different Cry1Ab hybrids that could contribute to the decline in control efficacy. Supportive data from laboratory bioassays demonstrate significant differences in weight gain and fitness characteristics between the Maryland H. zea strain and a susceptible strain. In bioassays with Cry1Ab expressing green leaf tissue, Maryland H. zea strain gained more weight than the susceptible strain at all concentrations tested. Fitness of the Maryland H. zea strain was significantly lower than that of the susceptible strain as indicated by lower hatch rate, longer time to adult eclosion, lower pupal weight, and reduced survival to adulthood. Conclusions/Significance After ruling out possible contributing factors, the rapid change in field efficacy in recent years and decreased susceptibility of H. zea to Bt sweet corn provide strong evidence of field-evolved resistance in H. zea populations to multiple Cry toxins. The high adoption rate of Bt field corn and cotton, along with the moderate dose expression of Cry1Ab and related Cry toxins in these crops, and decreasing refuge compliance probably contributed to the evolution of resistance. Our results have important implications for resistance monitoring, refuge requirements and other regulatory policies, cross-resistance issues, and the sustainability of the pyramided Bt technology. C1 [Dively, Galen P.; Venugopal, P. Dilip] Univ Maryland, Dept Entomol, College Pk, MD 20742 USA. [Venugopal, P. Dilip] US EPA, Amer Assoc Adv Sci, Sci & Technol Policy Fellowship Program, Transportat & Climate Div,Off Transportat & Air Q, Washington, DC USA. [Finkenbinder, Chad] Benzon Res Inc, Carlisle, PA USA. RP Venugopal, PD (reprint author), Univ Maryland, Dept Entomol, College Pk, MD 20742 USA.; Venugopal, PD (reprint author), US EPA, Amer Assoc Adv Sci, Sci & Technol Policy Fellowship Program, Transportat & Climate Div,Off Transportat & Air Q, Washington, DC USA. EM venugopal.dilip@gmail.com FU Maryland Agricultural Experiment Station [MD-ENTO-8732]; Maryland Extension Integrated Pest Management Project; United States Environmental Protection Agency (U.S. EPA) [X3-83588701] FX This work was supported by the Maryland Agricultural Experiment Station, #MD-ENTO-8732 (GPD) and the Maryland Extension Integrated Pest Management Project (GPD). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.; This publication was developed under Assistance Agreement No. X3-83588701 awarded by the United States Environmental Protection Agency (U.S. EPA) to the American Association for the Advancement of Science (AAAS). It has not been formally reviewed by the U.S. EPA. The views expressed in this document are solely those of the authors, and do not reflect those of either U.S. EPA or AAAS. Products or commercial services mentioned in this publication are solely for reference purposes only, and do not represent endorsement by the authors, the U.S. EPA, or AAAS. NR 83 TC 0 Z9 0 U1 22 U2 22 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 30 PY 2016 VL 11 IS 12 AR e0169115 DI 10.1371/journal.pone.0169115 PG 22 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EG7LN UT WOS:000391229300056 PM 28036388 ER PT J AU Hidalgo, AIC Aguirre, MR Valenzuela, E Gomez, JYV Davila, AC Varma, RS Sanchez, VHR AF Casas Hidalgo, Ana I. Roman Aguirre, Manuel Valenzuela, Edgar Verde Gomez, Jose Y. Camacho Davila, Alejandro Varma, Rajender S. Ramos Sanchez, Victor H. TI Sustainable application of pecan nutshell waste: Greener synthesis of Pd-based nanocatalysts for electro-oxidation of methanol SO INTERNATIONAL JOURNAL OF HYDROGEN ENERGY LA English DT Article; Proceedings Paper CT 15th International Congress of the Mexican-Hydrogen-Society CY SEP 22-25, 2015 CL Mexico City, MEXICO SP Mexican Hydrogen Soc, Ctr Res Adv Studies Unit Zacatenco DE Pecan (Carya illinoinensis) shell extract; Green Au Pd nanoparticles; Bimetallic alloy; Microwave-assisted synthesis; Alkaline methanol fuel cells ID PALLADIUM NANOPARTICLES; METAL NANOPARTICLES; ALKALINE MEDIA; AU; ACTIVATION; PRODUCTS; EXTRACT; CARBON AB Palladium-based electrocatalysts are widely used in alkaline direct alcohol fuel cells. The synthesis and characterization of carbon-supported bimetallic nanoparticles (NP) of AuPd and AgPd is described using pecan nutshell extract (Carya illinoinensis) which serves as both, reducing and the stabilizing agent. This environmentally friendly route generates bimetallic NP for a wide range of applications, including electrocatalysis; since particularly AuPd NP proved to be a potentially suitable electrode material for alkaline direct methanol fuel cells. The electrocatalytic activity of these nanomaterials was comparable to commercially available Pd/C 1% in the electro-oxidation of methanol in alkaline media. (C) 2016 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved. C1 [Casas Hidalgo, Ana I.; Camacho Davila, Alejandro; Ramos Sanchez, Victor H.] Univ Autonoma Chihuahua, Cuerpo Acad Quim Aplicada & Educ, Fac Ciencias Quim, Nuevo Campus Univ, Chihuahua 31125, Chih, Mexico. [Roman Aguirre, Manuel] Ctr Invest Mat Avanzados SC, Miguel de Cervantes 120, Chihuahua 31109, Chih, Mexico. [Valenzuela, Edgar] Univ Autonoma Baja California, Fac Ingn, Campus Mexicali,Blvd Benito Juarez S-N, Mexicali 21900, Baja California, Mexico. [Verde Gomez, Jose Y.] Inst Tecnol Cancun, Lab Energia & Medio Ambiente, Ave Kabah Km 3 S-N, Cancun 77500, Q Roo, Mexico. [Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Sanchez, VHR (reprint author), Univ Autonoma Chihuahua, Cuerpo Acad Quim Aplicada & Educ, Fac Ciencias Quim, Nuevo Campus Univ, Chihuahua 31125, Chih, Mexico. EM vramos@uach.mx NR 23 TC 0 Z9 0 U1 10 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0360-3199 EI 1879-3487 J9 INT J HYDROGEN ENERG JI Int. J. Hydrog. Energy PD DEC 28 PY 2016 VL 41 IS 48 BP 23329 EP 23335 DI 10.1016/j.ijhydene.2016.07.275 PG 7 WC Chemistry, Physical; Electrochemistry; Energy & Fuels SC Chemistry; Electrochemistry; Energy & Fuels GA EG5IL UT WOS:000391077400077 ER PT J AU Hicks, DJ AF Hicks, Daniel J. TI Bibliometrics for Social Validation SO PLoS One LA English DT Article AB This paper introduces a bibliometric, citation network-based method for assessing the social validation of novel research, and applies this method to the development of high-throughput toxicology research at the US Environmental Protection Agency. Social validation refers to the acceptance of novel research methods by a relevant scientific community; it is formally independent of the technical validation of methods, and is frequently studied in history, philosophy, and social studies of science using qualitative methods. The quantitative methods introduced here find that high-throughput toxicology methods are spread throughout a large and well-connected research community, which suggests high social validation. Further assessment of social validation involving mixed qualitative and quantitative methods are discussed in the conclusion. C1 [Hicks, Daniel J.] Univ Western Ontario, Rotman Inst Philosophy, London, ON, Canada. [Hicks, Daniel J.] US EPA, Amer Assoc Adv Sci, Off Res & Dev, Washington, DC 20460 USA. RP Hicks, DJ (reprint author), Univ Western Ontario, Rotman Inst Philosophy, London, ON, Canada.; Hicks, DJ (reprint author), US EPA, Amer Assoc Adv Sci, Off Res & Dev, Washington, DC 20460 USA. EM hicks.daniel.j@gmail.com NR 30 TC 0 Z9 0 U1 3 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 22 PY 2016 VL 11 IS 12 AR e0168597 DI 10.1371/journal.pone.0168597 PG 15 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EI9QH UT WOS:000392843200069 PM 28005974 ER PT J AU Dhar, BR Ryu, H Ren, H Domingo, JWS Chae, J Lee, HS AF Dhar, Bipro Ranjan Ryu, Hodon Ren, Hao Domingo, Jorge W. Santo Chae, Junkseck Lee, Hyung-Sool TI High Biofilm Conductivity Maintained Despite Anode Potential Changes in a Geobacter-Enriched Biofilm SO CHEMSUSCHEM LA English DT Article DE biomass; cascade process; cellulose; heterogeneous acid catalyst; sulfonated carbon ID SOLID ACID CATALYSTS; BIODEGRADABLE SURFACTANTS; LIGNOCELLULOSIC BIOMASS; ENZYMATIC-HYDROLYSIS; CHEMICALS SYNTHESIS; BUTYL GLYCOSIDES; IONIC LIQUIDS; CELLULOSE; CONVERSION; OXIDE AB This study systematically assessed intracellular electron transfer (IET) and extracellular electron transfer (EET) kinetics with respect to anode potential (E-anode) in a mixed-culture biofilm anode enriched with Geobacter spp. High biofilm conductivity (0.96-1.24 mS cm(-1)) was maintained during E-anode changes from -0.2 to +0.2 V versus the standard hydrogen electrode (SHE), although the steady-state current density significantly decreased from 2.05 to 0.35 Am-2 in a microbial electrochemical cell. Substantial increase of the Treponema population was observed in the biofilm anode at E-anode = +0.2 V, which reduced intracellular electron-transfer kinetics associated with the maximum specific substrate-utilization rate by a factor of ten. This result suggests that fast EET kinetics can be maintained under dynamic E-anode conditions in a highly conductive biofilm anode as a result of shift of main EET players in the biofilm anode, although E-anode changes can influence IET kinetics. C1 [Lee, Hyung-Sool] Univ Waterloo, Civil & Environm Engn, 200 Univ Ave, West Waterloo, ON N2L 3G1, Canada. [Dhar, Bipro Ranjan] Univ Alberta, Civil & Environm Engn, 9211-116 St NW, Edmonton, AB T6G 1H9, Canada. [Ryu, Hodon; Domingo, Jorge W. Santo] US EPA, Natl Risk Management Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. [Ren, Hao; Chae, Junkseck] Arizona State Univ, Sch Elect Comp & Energy Engn, Tempe, AZ 85287 USA. RP Lee, HS (reprint author), Univ Waterloo, Civil & Environm Engn, 200 Univ Ave, West Waterloo, ON N2L 3G1, Canada. EM hyungsool@uwaterloo.ca FU Solvay; Spanish MICINN [CTQ-2015-67592-P]; Spanish Ministry of Education and Science FX Support by Solvay is gratefully acknowledged. Spanish MICINN Project (CTQ-2015-67592-P), Generalitat Valenciana (Prometeo Program), Severo Ochoa Program are gratefully acknowledged. S.M.S thanks Spanish Ministry of Education and Science and Solvay for an FPI fellowships. NR 63 TC 0 Z9 0 U1 0 U2 0 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 1864-5631 EI 1864-564X J9 CHEMSUSCHEM JI ChemSusChem PD DEC 20 PY 2016 VL 9 IS 24 BP 3485 EP 3502 DI 10.1002/cssc.201601007 PG 18 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY SC Chemistry; Science & Technology - Other Topics GA EL4DI UT WOS:000394571500017 PM 27870324 ER PT J AU Kioutsioukis, I Im, U Solazzo, E Bianconi, R Badia, A Balzarini, A Baro, R Bellasio, R Brunner, D Chemel, C Curci, G van der Gon, HD Flemming, J Forkel, R Giordano, L Jimenez-Guerrero, P Hirtl, M Jorba, O Manders-Groot, A Neal, L Perez, JL Pirovano, G Jose, RS Savage, N Schroder, W Sokhi, RS Syrakov, D Tuccella, P Werhahn, J Wolke, R Hogrefe, C Galmarini, S AF Kioutsioukis, Ioannis Im, Ulas Solazzo, Efisio Bianconi, Roberto Badia, Alba Balzarini, Alessandra Baro, Rocio Bellasio, Roberto Brunner, Dominik Chemel, Charles Curci, Gabriele van der Gon, Hugo Denier Flemming, Johannes Forkel, Renate Giordano, Lea Jimenez-Guerrero, Pedro Hirtl, Marcus Jorba, Oriol Manders-Groot, Astrid Neal, Lucy Perez, Juan L. Pirovano, Guidio Jose, Roberto San Savage, Nicholas Schroder, Wolfram Sokhi, Ranjeet S. Syrakov, Dimiter Tuccella, Paolo Werhahn, Johannes Wolke, Ralf Hogrefe, Christian Galmarini, Stefano TI Insights into the deterministic skill of air quality ensembles from the analysis of AQMEII data SO ATMOSPHERIC CHEMISTRY AND PHYSICS LA English DT Article ID MODEL EVALUATION; MULTIMODEL ENSEMBLES; NORTH-AMERICA; OZONE FORECASTS; EUROPE; CONTEXT; PREDICTIONS; PERFORMANCE; METEOROLOGY; IMPROVE AB Simulations from chemical weather models are subject to uncertainties in the input data (e.g. emission inventory, initial and boundary conditions) as well as those intrinsic to the model (e.g. physical parameterization, chemical mechanism). Multi-model ensembles can improve the forecast skill, provided that certain mathematical conditions are fulfilled. In this work, four ensemble methods were applied to two different datasets, and their performance was compared for ozone (O-3), nitrogen dioxide (NO2) and particulate matter (PM10). Apart from the unconditional ensemble average, the approach behind the other three methods relies on adding optimum weights to members or constraining the ensemble to those members that meet certain conditions in time or frequency domain. The two different datasets were created for the first and second phase of the Air Quality Model Evaluation International Initiative (AQMEII). The methods are evaluated against ground level observations collected from the EMEP (European Monitoring and Evaluation Programme) and AirBase databases. The goal of the study is to quantify to what extent we can extract predictable signals from an ensemble with superior skill over the single models and the ensemble mean. Verification statistics show that the deterministic models simulate better O-3 than NO2 and PM10, linked to different levels of complexity in the represented processes. The unconditional ensemble mean achieves higher skill compared to each station's best deterministic model at no more than 60% of the sites, indicating a combination of members with unbalanced skill difference and error dependence for the rest. The promotion of the right amount of accuracy and diversity within the ensemble results in an average additional skill of up to 31% compared to using the full ensemble in an unconditional way. The skill improvements were higher for O-3 and lower for PM10, associated with the extent of potential changes in the joint distribution of accuracy and diversity in the ensembles. The skill enhancement was superior using the weighting scheme, but the training period required to acquire representative weights was longer compared to the sub-selecting schemes. Further development of the method is discussed in the conclusion. C1 [Kioutsioukis, Ioannis] Univ Patras, Dept Phys, Univ Campus, Patras 26504, Greece. [Kioutsioukis, Ioannis; Solazzo, Efisio; Galmarini, Stefano] European Commiss, Joint Res Ctr, Directorate Energy Transport & Climate Air & Clim, Ispra, VA, Italy. [Im, Ulas] Aarhus Univ, Dept Environm Sci, Roskilde, Denmark. [Bianconi, Roberto; Bellasio, Roberto] Enviroware Srl, Concorezzo, MB, Italy. [Badia, Alba; Jorba, Oriol] BSC CNS, Earth Sci Dept, Barcelona, Spain. [Balzarini, Alessandra; Pirovano, Guidio] RSE SpA, Milan, Italy. [Brunner, Dominik; Giordano, Lea] Empa, Lab Air Pollut & Environm Technol, Dubendorf, Switzerland. [Chemel, Charles; Sokhi, Ranjeet S.] Univ Hertfordshire, Ctr Atmospher & Instrumentat Res, Coll Lane, Hatfield AL10 9AB, Herts, England. [Curci, Gabriele; Tuccella, Paolo] Univ Aquila, Dept Phys & Chem Sci, Laquila, Italy. [Curci, Gabriele; Tuccella, Paolo] Univ Aquila, Ctr Excellence Forecast Severe Weather CETEMPS, Laquila, Italy. [van der Gon, Hugo Denier; Manders-Groot, Astrid] Netherlands Org Appl Sci Res TNO, Utrecht, Netherlands. [Baro, Rocio; Jimenez-Guerrero, Pedro] Univ Murcia, Dept Phys, Phys Earth, Campus Espinardo,Ed CIOyN, E-30100 Murcia, Spain. [Flemming, Johannes] ECMWF, Shinfield Pk, Reading RG2 9AX, Berks, England. [Forkel, Renate; Werhahn, Johannes] KIT, IMK IFU, Kreuzeckbahnstr 19, D-82467 Garmisch Partenkirchen, Germany. [Hirtl, Marcus; Savage, Nicholas] ZAMG, Zentralanstalt Meteorol & Geodynam, A-1190 Vienna, Austria. [Neal, Lucy; Jose, Roberto San] Met Off, FitzRoy Rd, Exeter EX1 3PB, Devon, England. [Perez, Juan L.] Tech Univ Madrid, Sch Comp Sci, Environm Software & Modelling Grp, Campus Montegancedo Boadilla del Monte, Madrid 28660, Spain. [Schroder, Wolfram; Wolke, Ralf] Leibniz Inst Tropospher Res, Permoserstr 15, D-04318 Leipzig, Germany. [Syrakov, Dimiter] Bulgarian Acad Sci, Natl Inst Meteorol & Hydrol, 66 Tzarigradsko Shaussee Blvd, BU-1784 Sofia, Bulgaria. [Hogrefe, Christian] Environm Protect Agcy, Atmospher Modelling & Anal Div, Res Triangle Pk, NC USA. RP Galmarini, S (reprint author), European Commiss, Joint Res Ctr, Directorate Energy Transport & Climate Air & Clim, Ispra, VA, Italy. EM stefano.galmarini@jrc.ec.europa.eu RI Brunner, Dominik/A-1255-2009; Forkel, Renate/A-8743-2013; Curci, Gabriele/A-2020-2011; OI Brunner, Dominik/0000-0002-4007-6902; Forkel, Renate/0000-0001-6452-344X; Curci, Gabriele/0000-0001-9871-5570; solazzo, efisio/0000-0002-6333-1101; Im, Ulas/0000-0001-5177-5306 FU European contribution through COST Action [ES1004 EuMetChem]; Italian Space Agency (ASI) [1/017/11/0] FX We gratefully acknowledge the contribution of various groups to the second Air Quality Model Evaluation international Initiative (AQMEII) activity: US EPA, Environment Canada, Mexican Secretariat of the Environment and Natural Resources (Secretaria de Medio Ambiente y Recursos Naturales-SEMARNAT) and National Institute of Ecology (Instituto Nacional de Ecologia-INE) (North American national emissions inventories); US EPA (North American emissions processing); TNO (European emissions processing); ECMWF/MACC project & Meteo-France/CNRM-GAME (Chemical boundary conditions). Ambient North American concentration measurements were extracted from Environment Canada's National Atmospheric Chemistry Database (NAtChem) PM database and provided by several US and Canadian agencies (AQS, CAPMoN, CASTNet, IMPROVE, NAPS, SEARCH and STN networks); North American precipitation-chemistry measurements were extracted from NAtChem's precipitation-chemistry database and were provided by several US and Canadian agencies (CAPMoN, NADP, NBPMN, NSPSN, and REPQ networks); the WMO World Ozone and Ultraviolet Data Centre (WOUDC) and its data-contributing agencies provided North American and European ozone sonde profiles; NASA's Aerosol Robotic Network (AeroNet) and its data-contributing agencies provided North American and European AOD measurements; the MOZAIC Data Centre and its contributing airlines provided North American and European aircraft take-off and landing vertical profiles. For European air quality data the following data centres were used: EMEP European Environment Agency, European Topic Center on Air and Climate Change, and AirBase provided European air-and precipitation-chemistry data. The Finnish Meteorological Institute is acknowledged for providing biomass burning emission data for Europe. Data from meteorological station monitoring networks were provided by NOAA and Environment Canada (for the US and Canadian meteorological network data) and the National Center for Atmospheric Research (NCAR) data support section. Joint Research Center Ispra and Institute for Environment and Sustainability provided their ENSEMBLE system for model output harmonization and analyses and evaluation. The co-ordination and support of the European contribution through COST Action ES1004 EuMetChem is gratefully acknowledged. The views expressed here are those of the authors and do not necessarily reflect the views and policies of the US Environmental Protection Agency (EPA) or any other organization participating in the AQMEII project. This paper has been subjected to EPA review and approved for publication. The UPM authors thankfully acknowledge the computer resources, technical expertise, and assistance provided by the Centro de Supercomputacion y Visualizacion de Madrid (CESVIMA) and the Spanish Supercomputing Network (BSC). GC and PT were supported by the Italian Space Agency (ASI) in the frame of the PRIMES project (contract no. 1/017/11/0). The same authors are deeply thankful to the Euro Mediterranean Centre on Climate Change (CMCC) for having made available the computational resources. NR 39 TC 1 Z9 1 U1 2 U2 2 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1680-7316 EI 1680-7324 J9 ATMOS CHEM PHYS JI Atmos. Chem. Phys. PD DEC 20 PY 2016 VL 16 IS 24 BP 15629 EP 15652 DI 10.5194/acp-16-15629-2016 PG 24 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA EH1VK UT WOS:000391555500001 ER PT J AU Bosle, J Goetz, S Raab, A Krupp, EM Schecke, KG Lorrb, E Meharg, AA Fowler, PA Feldmann, J AF Bosle, Janine Goetz, Sven Raab, Andrea Krupp, Eva M. Schecke, Kirk G. Lorrb, Enzo Meharg, Andrew A. Fowler, Paul A. Feldmann, Jorg TI Cobalamin Concentrations in Fetal Liver Show Gender Differences: A Result from Using a High-Pressure Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry as an Ultratrace Cobalt Speciation Method SO ANALYTICAL CHEMISTRY LA English DT Article ID VITAMIN-B-12; HPLC AB Maternal diet and lifestyle choices may affect placental transfer of cobalamin (Cbl) to the fetus. Fetal liver concentration of Cbl reflects nutritional status with regards to vitamin B12, but at these low concentration current Cbl measurement methods lack robustness. An analytical method based on enzymatic extraction with subsequent reversed-phase high -pressure liquid chromatography (RP-HPLC) separation and parallel ICPMS and electrospray ionization (ESI)-Orbitrap-MS to determine specifically Cbl species in liver samples of only 10-50 mg was developed using 14 pig livers. Subsequently 55 human fetal livers were analyzed. HPLC ICPMS analysis for cobalt (Co) and Cbl gave detection limits of 0.18 ng/g and 0.88 ng/g d.m. in liver samples, respectively, with a recovery of >95%. Total Co (Cot) concentration did not reflect the amount of Cbl or vitamin B12 in the liver. Cbl bound Co contributes only 45 +/- 15% to Cot. XRF mapping and mu XANES analysis confirmed the occurrence of non-Cbl cobalt in pig liver hot spots indicating particular Co. No correlations of total cobalt nor Cbl with fetal weight or weeks of gestation were found for the human fetal livers. Although no gender difference could be identified for total Co concentration, female livers were significantly higher in Cbl concentration (24.1 +/- 7.8 ng/g) than those from male fetuses (19.8 +/- 7.1 ng/g) (p = 0.04). This HPLC ICPMS method was able to quantify total Co-t and Cbl in fetus liver, and it was sensitive and precise enough to identify this gender difference. C1 [Bosle, Janine; Goetz, Sven; Raab, Andrea; Krupp, Eva M.; Feldmann, Jorg] Univ Aberdeen, Dept Chem, TESLA Trace Element Speciat Lab, Meston Walk, Aberdeen AB24 3UE, Scotland. [Schecke, Kirk G.] US EPA, Natl Risk Management Res Lab, Land Remediat & Pollut Control Div, 5995 Ctr Hill Ave, Cincinnati, OH 45224 USA. [Lorrb, Enzo] Univ South Australia, Future Ind Inst, Bldg X,Mawson Lakes Campus, Mawson Lakes, SA 5095, Australia. [Meharg, Andrew A.] Queens Univ Belfast, Inst Global Food Secur, Malone Rd, Belfast BT9 5BN, Antrim, North Ireland. [Fowler, Paul A.] Univ Aberdeen, Sch Med Med Sci & Nutr, Inst Med Sci, Aberdeen AB25 2ZD, Scotland. RP Feldmann, J (reprint author), Univ Aberdeen, Dept Chem, TESLA Trace Element Speciat Lab, Meston Walk, Aberdeen AB24 3UE, Scotland. EM j.feldmann@abdn.ac.uk OI Feldmann, Joerg/0000-0002-0524-8254 FU Chief Scientist Office (Scottish Executive) [CZG/1/109, CZG/4/742]; NHS Grampian Endowments [08/02]; European Community [212885]; Medical Research Council [MR/L010011/1] FX Chief Scientist Office (Scottish Executive, Grant CZG/1/109 (P.A.F.) and Grant CZG/4/742 (P.A.F.); NHS Grampian Endowments 08/02 (P.A.F.); the European Community's Seventh Framework Programme (Grant FP7/2007-2013) under Grant Agreement No. 212885 (P.A.F.); and the Medical Research Council Grant MR/L010011/1 (P.A.F.). NR 15 TC 0 Z9 0 U1 6 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 EI 1520-6882 J9 ANAL CHEM JI Anal. Chem. PD DEC 20 PY 2016 VL 88 IS 24 BP 12419 EP 12426 DI 10.1021/acs.analchem.6b03730 PG 8 WC Chemistry, Analytical SC Chemistry GA EF8ZR UT WOS:000390621000062 PM 28193074 ER PT J AU Carriger, JF Barron, MG Newnian, MC AF Carriger, John F. Barron, Mace G. Newnian, Michael C. TI Bayesian Networks Improve Causal Environmental Assessments for Evidence-Based Policy SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID ECOLOGICAL RISK-ASSESSMENT; INFLUENCE DIAGRAMS; BELIEF NETWORKS; WIND FARMS; MANAGEMENT; PROBABILITY; UNCERTAINTY; JUDGMENT; CARCASS; OIL AB Rule-based weight of evidence approaches to ecological risk assessment may not account for uncertainties and generally lack probabilistic integration of lines of evidence. Bayesian networks allow causal inferences to be made from evidence by including causal knowledge about the problem, using this knowledge with probabilistic calculus to combine multiple lines of evidence, and minimizing biases in predicting or diagnosing causal relationships. Too often, sources of uncertainty in conventional weight of evidence approaches are ignored that can be accounted for with Bayesian networks. Specifying and propagating uncertainties improve the ability of models to incorporate strength of the evidence in the risk management phase of an assessment. Probabilistic inference from a Bayesian network allows evaluation of changes in uncertainty for variables from the evidence. The network structure and probabilistic framework of a Bayesian approach provide advantages over qualitative approaches in weight of evidence for capturing the impacts of multiple sources of quantifiable uncertainty on predictions of ecological risk. Bayesian networks can facilitate the development of evidence-based policy under conditions of uncertainty by incorporating analytical inaccuracies or the implications of imperfect information, structuring and communicating causal issues through qualitative directed graph formulations, and quantitatively comparing the causal power of multiple stressors on valued ecological resources. These aspects are demonstrated through hypothetical problem scenarios that explore some major benefits of using Bayesian networks for reasoning and making inferences in evidence-based policy. C1 [Carriger, John F.] US EPA, Oak Ridge Inst Sci & Educ, Off Res & Dev, Natl Hlth & Environm Effects Res Lab,Gulf Ecol Di, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA. [Barron, Mace G.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA. [Newnian, Michael C.] Virginia Inst Marine Sci, Coll William & Mary, POB 1346,Route 1208 Greate Rd, Gloucester Point, VA 23062 USA. RP Carriger, JF (reprint author), US EPA, Oak Ridge Inst Sci & Educ, Off Res & Dev, Natl Hlth & Environm Effects Res Lab,Gulf Ecol Di, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA. EM carriger.john@epa.gov FU U.S. Environmental Protection Agency; U.S. Department of Energy FX This article is dedicated to Bonnie Carriger. This research was supported in part by an appointment to the ORISE participant research program through an interagency agreement between the U.S. Environmental Protection Agency and the U.S. Department of Energy. The views expressed in this article are those of the authors and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency. M.C. Newman was the A. Marshall Acuff Jr. Professor of Marine Science during the tenure of this study. NR 54 TC 0 Z9 0 U1 11 U2 11 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD DEC 20 PY 2016 VL 50 IS 24 BP 13195 EP 13205 DI 10.1021/acs.est.6b03220 PG 11 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA EF8ZQ UT WOS:000390620900004 PM 27993076 ER PT J AU Baig, RBN Verma, S Nadagouda, MN Varma, RS AF Baig, R. B. Nasir Verma, Sanny Nadagouda, Mallikarjuna N. Varma, Rajender S. TI Room temperature synthesis of biodiesel using sulfonated graphitic carbon nitride SO SCIENTIFIC REPORTS LA English DT Article ID SOLID ACID CATALYST; TRANSPORTATION FUELS; LEVULINIC ACID; ESTERIFICATION; ENERGY; CHEMISTRY; EFFICIENT; BIOMASS; TRANSESTERIFICATION; NANOPARTICLES AB Sulfonation of graphitic carbon nitride (g-CN) affords a polar and strongly acidic catalyst, Sg-CN, which displays unprecedented reactivity and selectivity in biodiesel synthesis and esterification reactions at room temperature. C1 [Baig, R. B. Nasir; Verma, Sanny; Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, MS 443, Cincinnati, OH 45268 USA. [Nadagouda, Mallikarjuna N.] US EPA, WQMB, WSWRD, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Varma, RS (reprint author), US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, MS 443, Cincinnati, OH 45268 USA.; Nadagouda, MN (reprint author), US EPA, WQMB, WSWRD, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. EM nadagouda.mallikarjuna@epa.gov; varma.rajender@epa.gov FU Postgraduate Research Program at the National Risk Management Research Laboratory FX RBNB and SV were supported by the Postgraduate Research Program at the National Risk Management Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and the U.S. Environmental Protection Agency. NR 39 TC 0 Z9 0 U1 19 U2 19 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD DEC 19 PY 2016 VL 6 AR 39387 DI 10.1038/srep39387 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EE8MF UT WOS:000389879300001 PM 27991593 ER PT J AU Xie, MJ Mladenov, N Williams, MW Neff, JC Wasswa, J Hannigan, MP AF Xie, Mingjie Mladenov, Natalie Williams, Mark W. Neff, Jason C. Wasswa, Joseph Hannigan, Michael P. TI Water soluble organic aerosols in the Colorado Rocky Mountains, USA: composition, sources and optical properties SO SCIENTIFIC REPORTS LA English DT Article ID POSITIVE MATRIX FACTORIZATION; ATMOSPHERIC PARTICULATE MATTER; DICARBOXYLIC-ACIDS; FLUORESCENCE SPECTROSCOPY; CHEMICAL-COMPOSITION; SEASONAL-VARIATIONS; KETOCARBOXYLIC ACIDS; ELEMENTAL CARBON; ALPHA-PINENE; DUST AB Atmospheric aerosols have been shown to be an important input of organic carbon and nutrients to alpine watersheds and influence biogeochemical processes in these remote settings. For many remote, high elevation watersheds, direct evidence of the sources of water soluble organic aerosols and their chemical and optical characteristics is lacking. Here, we show that the concentration of water soluble organic carbon (WSOC) in the total suspended particulate (TSP) load at a high elevation site in the Colorado Rocky Mountains was strongly correlated with UV absorbance at 254 nm (Abs254, r = 0.88 p < 0.01) and organic carbon (OC, r = 0.95 p < 0.01), accounting for >90% of OC on average. According to source apportionment analysis, biomass burning had the highest contribution (50.3%) to average WSOC concentration; SOA formation and motor vehicle emissions dominated the contribution to WSOC in the summer. The source apportionment and backward trajectory analysis results supported the notion that both wildfire and Colorado Front Range pollution sources contribute to the summertime OC peaks observed in wet deposition at high elevation sites in the Colorado Rocky Mountains. These findings have important implications for water quality in remote, high-elevation, mountain catchments considered to be our pristine reference sites. C1 [Xie, Mingjie; Hannigan, Michael P.] Univ Colorado, Dept Mech Engn, Boulder, CO 80309 USA. [Mladenov, Natalie; Wasswa, Joseph] San Diego State Univ, Dept Civil Construct & Environm Engn, San Diego, CA 92182 USA. [Williams, Mark W.] Univ Colorado, Inst Arctic & Alpine Res, Boulder, CO 80309 USA. [Williams, Mark W.] Univ Colorado, Dept Geog, Boulder, CO 80309 USA. [Neff, Jason C.] Univ Colorado, Dept Geol, Boulder, CO 80309 USA. [Xie, Mingjie] US EPA, Natl Risk Management Res Lab, Off Res & Dev, 109 TW Alexander Dr, Res Triangle Pk, NC 27709 USA. RP Mladenov, N (reprint author), San Diego State Univ, Dept Civil Construct & Environm Engn, San Diego, CA 92182 USA. EM nmladenov@sdsu.edu FU National Science Foundation (NSF) [EAR 1124576]; SDSU University Grants Program; Niwot Ridge Long Term Ecological Research project [DEB 1027341]; Boulder Creek Critical Zone Observatory [EAR 0724960] FX The authors thank D. Fernandez and J. Morse for field support, H. Hughes and C. Seibold for assistance with wet chemistry, and T.B. Wellemeyer, S. Lemons, and K. Oldani for performing fluorescence EEM acquisition. We thank D. M. McKnight for access to and use of fluorescence and UV-vis absorbance instrumentation. The authors gratefully acknowledge the NOAA Air Resources Laboratory (ARL) for the provision of the HYSPLIT transport and dispersion model and READY website (http://www.ready.noaa.gov) used in this publication. This project was funded by a National Science Foundation (NSF) grant (EAR 1124576) to N. Mladenov and M. Williams and a SDSU University Grants Program award to N. Mladenov. NSF support was also provided by the Niwot Ridge Long Term Ecological Research project (DEB 1027341) and Boulder Creek Critical Zone Observatory (EAR 0724960). NR 78 TC 0 Z9 0 U1 14 U2 14 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD DEC 19 PY 2016 VL 6 AR 39339 DI 10.1038/srep39339 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EE8LE UT WOS:000389876300001 PM 27991554 ER PT J AU Pelaez, M Falaras, P Likodimos, V O'Shea, K de la Cruz, AA Dunlop, PSM Byrne, JA Dionysiou, DD AF Pelaez, Miguel Falaras, Polycarpos Likodimos, Vlassis O'Shea, Kevin de la Cruz, Armah A. Dunlop, Patrick S. M. Byrne, J. Anthony Dionysiou, Dionysios D. TI Use of selected scavengers for the determination of NF-TiO2 reactive oxygen species during the degradation of microcystin-LR under visible light irradiation SO JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL LA English DT Article DE NF-TiO2; Reactive oxygen species; Hydroxyl radical; Superoxide radical anion; Singlet oxygen; Visible light; Microcystin-LR ID DOPED TIO2 PHOTOCATALYSTS; TIO2-ASSISTED PHOTODEGRADATION; ENVIRONMENTAL APPLICATIONS; AQUEOUS SUSPENSIONS; TITANIUM-DIOXIDE; MECHANISM; WATER; IONS; NANOPARTICLES; REDUCTION AB Although UV-induced TiO2 photocatalysis involves the generation of several reactive oxygen species (ROS), the formation of hydroxyl radicals is generally associated with the degradation of persistent organic contaminants in water. In this study, a variety of radical scavengers were employed to discriminate the roles of different ROS during visible light-activated (VIA) photocatalysis using nitrogen and fluorine doped TiO2 (NF-TiO2) in the degradation of the hepatotoxin, microcystin-LR (MC-LR) in water. The addition of hydroxyl radical scavengers, methanol and tert-butyl alcohol to the reaction mixture resulted in negligible" inhibition of NF-TiO2 photocatalytic degradation of MC-LR at pH 3.0 and only partial inhibition at pH 5.7 under visible light. While hydroxyl radicals ("OH) generally play the primary role in UV-TiO2 photocatalysis, the minimal influence of MeOH and t-BuOH on the degradation process under these experimental conditions indicates that (OH)-O-center dot are not crucial in VIA NF-TiO2 photocatalysis. However, strong inhibition was observed in VIA NF-TiO2 photocatalytic degradation of MC-LR in the presence of superoxide dismutase, benzoquinone and catalase at pH 3.0 and 5.7 indicating that O-2(center dot-) and H2O2 play critical roles in the degradation process. Similar degradation rates were observed in the presence of deuterium oxide, which enhances singlet oxygen mediated processes further suggesting singlet oxygen is not a key species in the degradation of MC-LR. Formic acid and cupric nitrate were added to probe the roles of the valence band holes and conduction band electrons, respectively. Under UV-vis light irradiation, almost complete inhibition of MC-LR removal is observed with NF-TiO2 in the presence of "OH scavengers at pH 5.7. These results demonstrate that the solution pH plays a major role in the formation and reactivity of ROS during VIA NF-TiO2 photocatalysis. The adsorption strength of scavengers and MC-LR onto NF-TiO2 as well as the speciation of ROS as a function of pH needs to be carefully considered since they also play a major role in the efficiency of the process. These results indicate that the reduction of molecular oxygen by photo-generated electrons rather than hydroxyl radicals produced by oxidative reactions of photo-generated holes is the key factor in the VIA NF-TiO2 photocatalytic degradation of MC-LR. (C) 2016 Elsevier B.V. All rights reserved. C1 [Pelaez, Miguel; Dionysiou, Dionysios D.] Univ Cincinnati, Environm Engn & Sci Program, Cincinnati, OH 45221 USA. [Falaras, Polycarpos] NCSR Demokritos, Inst Nanosci & Nanotechnol, Athens 15310, Greece. [Likodimos, Vlassis] Univ Athens, Dept Phys, Sect Solid State Phys, Athens 15784, Greece. [O'Shea, Kevin] Florida Int Univ, Dept Chem & Biochem, Miami, FL 33199 USA. [de la Cruz, Armah A.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. [Dunlop, Patrick S. M.; Byrne, J. Anthony] Univ Ulster, Sch Engn, Nanotechnol & Integrated BioEngn Ctr, Coleraine BT37 0QB, Londonderry, North Ireland. RP Dionysiou, DD (reprint author), Univ Cincinnati, Environm Engn & Sci Program, Cincinnati, OH 45221 USA. EM dionysios.d.dionysiou@uc.edu RI Dunlop, Patrick/C-6970-2008 OI Dunlop, Patrick/0000-0002-0902-0847 FU US-Ireland R&D Partnership by NSF; DELNI (NSF) [CBET-1033317]; European Commission [227017]; Research DG of the European Commission within the joint RTD activities of the Environment; NMP Thematic Priorities/FP7; Prince Sultan Bin Abdulaziz International Prize for Water (PSIPW)-Alternative Water Resources Prize FX This work was funded under the US-Ireland R&D Partnership by NSF and DELNI (NSF CBET-1033317) and the European Commission (Clean Water Grant Agreement number 227017). Clean Water is a Collaborative Project co-funded by the Research DG of the European Commission within the joint RTD activities of the Environment and NMP Thematic Priorities/FP7. P.F. acknowledges funding by Prince Sultan Bin Abdulaziz International Prize for Water (PSIPW)-Alternative Water Resources Prize 2014. NR 40 TC 1 Z9 1 U1 10 U2 10 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1381-1169 EI 1873-314X J9 J MOL CATAL A-CHEM JI J. Mol. Catal. A-Chem. PD DEC 15 PY 2016 VL 425 BP 183 EP 189 DI 10.1016/j.molcata.2016.09.035 PG 7 WC Chemistry, Physical SC Chemistry GA EF9ES UT WOS:000390634100021 ER PT J AU Li, P Weng, LL Niu, HB Robinson, B King, T Conmy, R Lee, K Liu, L AF Li, Pu Weng, Linlu Niu, Haibo Robinson, Brian King, Thomas Conmy, Robyn Lee, Kenneth Liu, Lei TI Reynolds number scaling to predict droplet size distribution in dispersed and undispersed subsurface oil releases SO MARINE POLLUTION BULLETIN LA English DT Article DE Oil droplet size distribution; Modified Weber number scaling; Reynolds number scaling; Rosin-Rammler; Chemical dispersant; Dispersant to oil ratio ID DEEP-WATER OIL; GAS BLOWOUTS; INTERFACIAL-TENSION; MODEL; BREAKUP; COALESCENCE; SIMULATIONS; VISCOSITY; DEEPSPILL; VDROP AB This study was aimed at testing the applicability of modified Weber number scaling with Alaska North Slope (ANS) crude oil, and developing a Reynolds number scaling approach for oil droplet size prediction for high viscosity oils. Dispersant to oil ratio and empirical coefficients were also quantified. Finally, a two-step RosinRammler scheme was introduced for the determination of droplet size distribution. This new approach appeared more advantageous in avoiding the inconsistency in interfacial tension measurements, and consequently delivered concise droplet size prediction. Calculated and observed data correlated well based on Reynolds number scaling. The relation indicated that chemical dispersant played an important role in reducing the droplet size of ANS under different seasonal conditions. The proposed Reynolds number scaling and two-step Rosin-Rammler approaches provide a concise, reliable way to predict droplet size distribution, supporting decision making in chemical dispersant application during an offshore oil spill. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Li, Pu; Niu, Haibo] Dalhousie Univ, Dept Engn, Truro Campus, Truro, NS B2N 5E3, Canada. [Weng, Linlu; Liu, Lei] Dalhousie Univ, Dept Civil Engn, Sexton Campus, Halifax, NS B3H 4R2, Canada. [Robinson, Brian; King, Thomas] Fisheries & Oceans Canada, Bedford Inst Oceanog, Ctr Offshore Oil Gas & Energy Res, Dartmouth, NS B2Y 4A2, Canada. [Conmy, Robyn] US EPA, Off Res & Dev, Cincinnati, OH 45220 USA. [Lee, Kenneth] CSIRO, Oceans & Atmosphere Flagship, Bentley, WA 6102, Australia. RP Li, P (reprint author), Dalhousie Univ, Dept Engn, Truro Campus, Truro, NS B2N 5E3, Canada. EM Pu.Li@Dal.Ca FU Natural Sciences and Engineering Research Council of Canada Discovery Program (NSERC DG) [2014-04045]; Marine Environmental Observation Prediction and Response Network (MEOPAR) [1.16]; Department of Fisheries and Oceans Canada (DFO) [F5211-140316]; US Environmental Protection Agency (US EPA) FX This research was funded by the Natural Sciences and Engineering Research Council of Canada Discovery Program (NSERC DG) (2014-04045), and the Marine Environmental Observation Prediction and Response Network (MEOPAR) (project: 1.16). Although the research was funded in part by the Department of Fisheries and Oceans Canada (DFO) (project: F5211-140316) and US Environmental Protection Agency (US EPA), it has not been subjected to any DFO or US EPA review, and therefore does not necessarily reflect the views of the department, and no official endorsement should be inferred. NR 44 TC 0 Z9 0 U1 3 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0025-326X EI 1879-3363 J9 MAR POLLUT BULL JI Mar. Pollut. Bull. PD DEC 15 PY 2016 VL 113 IS 1-2 BP 332 EP 342 DI 10.1016/j.marpolbul.2016.10.005 PG 11 WC Environmental Sciences; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA EG0PL UT WOS:000390734600061 PM 27742130 ER PT J AU Hildenbrand, ZL Mach, PM McBride, EM Dorreyatim, MN Taylor, JT Carlton, DD Meik, JM Fontenot, BE Wright, KC Schug, KA Verbeck, GF AF Hildenbrand, Zacariah L. Mach, Phillip M. McBride, Ethan M. Dorreyatim, M. Navid Taylor, Josh T. Carlton, Doug D., Jr. Meik, Jesse M. Fontenot, Brian E. Wright, Kenneth C. Schug, Kevin A. Verbeck, Guido F. TI Point source attribution of ambient contamination events near unconventional oil and gas development SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE BTEX; Eagle Ford; Air quality; Mobile mass spectrometry ID BARNETT SHALE REGION; VOLATILE ORGANIC-COMPOUNDS; METHANE EMISSIONS; GROUNDWATER QUALITY; AIR-QUALITY; OPERATIONS; IMPACT; WATER; WELLS; TEXAS AB We present an analysis of ambient benzene, toluene, and xylene isomers in the Eagle Ford shale region of southern Texas. In situ air quality measurements using membrane inlet mobile mass spectrometry revealed ambient benzene and toluene concentrations as high as 1000 and 5000 parts-per-billion, respectively, originating from specific sub-processes on unconventional oil and gas well pad sites. The detection of highly variant contamination events attributable to natural gas flaring units, condensate tanks, compressor units, and hydrogen sulfide scavengers indicates that mechanical inefficiencies, and not necessarily the inherent nature of the extraction process as a whole, result in the release of these compounds into the environment. This awareness of ongoing contamination events contributes to an enhanced knowledge of ambient volatile organic compounds on a regional scale. While these reconnaissance measurements on their own do not fully characterize the fluctuations of ambient BTEX concentrations that likely exist in the atmosphere of the Eagle Ford Shale region, they do suggest that contamination events from unconventional oil and gas development can be monitored, controlled, and reduced. (C) 2016 Elsevier B.V. All rights reserved. C1 [Hildenbrand, Zacariah L.; Carlton, Doug D., Jr.; Meik, Jesse M.; Fontenot, Brian E.; Schug, Kevin A.] Univ Texas Arlington, Collaborat Labs Environm Anal & Remediat, Arlington, TX 76019 USA. [Hildenbrand, Zacariah L.; Taylor, Josh T.] Inform Environm LLC, Dallas, TX 75206 USA. [Mach, Phillip M.; McBride, Ethan M.; Verbeck, Guido F.] Univ North Texas, Dept Chem, Denton, TX 76203 USA. [Dorreyatim, M. Navid] Univ North Texas, Dept Mech & Energy Engn, Denton, TX 76203 USA. [Carlton, Doug D., Jr.; Schug, Kevin A.] Univ Texas Arlington, Dept Chem & Biochem, Arlington, TX 76019 USA. [Meik, Jesse M.] Tarleton State Univ, Dept Biol Sci, Stephenville, TX 76401 USA. [Wright, Kenneth C.] Inficon, Syracuse, NY 13057 USA. [Fontenot, Brian E.] US EPA, Water Qual Protect Div, Dallas, TX 75202 USA. RP Schug, KA (reprint author), Univ Texas Arlington, Collaborat Labs Environm Anal & Remediat, Arlington, TX 76019 USA.; Verbeck, GF (reprint author), Univ North Texas, Dept Chem, Denton, TX 76203 USA. EM kschug@uta.edu; gverbeck@unt.edu FU Shimadzu Institute for Research Technologies at The University of Texas at Arlington; Collaborative Laboratories for Environmental Analysis and Remediation at The University of Texas at Arlington FX The authors are thankful for the financial support from the Shimadzu Institute for Research Technologies and the Collaborative Laboratories for Environmental Analysis and Remediation at The University of Texas at Arlington that facilitated this research. This consortium is largely supported by philanthropic contributions by landowners, mineral rights owners, and citizens concerned about the potential environmental impacts of industrial processes. Most importantly, we would like to thank all of the landowners who participated in this study. NR 27 TC 1 Z9 1 U1 7 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD DEC 15 PY 2016 VL 573 BP 382 EP 388 DI 10.1016/j.scitotenv.2016.08.118 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA EF1FP UT WOS:000390071000036 PM 27572531 ER PT J AU Shah, V Luxton, TP Walker, VK Brumfield, T Yost, J Shah, S Wilkinson, JE Kambhampati, M AF Shah, Vishal Luxton, Todd Peter Walker, Virginia K. Brumfield, Terrell Yost, Jerry Shah, Shreya Wilkinson, Jeremy E. Kambhampati, Murty TI Fate and impact of zero-valent copper nanoparticles on geographically-distinct soils SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Copper nanoparticles; Environmental impact; Transport; Bacteria; Regression model ID SILVER NANOPARTICLES; NATURAL SOILS; TRANSPORT; DISSOLUTION; COLUMNS; TREES; SAND; IRON AB The fate of engineered zero-valent copper nanoparticles (Cu NPs) in soils collected from geographically-distinct regions of the continental United States and incubated under controlled conditions was investigated with respect to NP affinity for soil surfaces and changes in speciation, as well as their impact on bacterial communities. Soil geochemical properties had a great influence on Cu NP migration and transformation. Translocation of Cu NPs was low in soils enriched in organic matter and high in clay and sandy soils. X-ray absorption spectroscopic analysis showed that the highest rates for transformation to Cu ions and adsorption complexes was in acidic soils. Although there was some change in overall bacterial community richness at the level of order in, experimental soil, the level of perturbation was evident in side-by-side comparisons of orders using a 50% microbial community change value (MCC50). This assessment revealed that generally, Sphingomonas, known for its importance for re mediation, and Rhizobiales, symbiotic partners with certain plants appeared susceptible to Cu NPs and their transformation products. The ecological importance of organisms from these orders and its greater vulnerability to Cu NPs suggests need for future targeted studies. (C) 2016 Elsevier B.V. All rights reserved. C1 [Shah, Vishal; Shah, Shreya] West Chester Univ, Coll Sci & Math, W Chester, PA 19382 USA. [Luxton, Todd Peter] US Environm Protect Agcy, Natl Risk Management Res Lab, Cincinnati, OH 45224 USA. [Walker, Virginia K.] Queens Univ, Dept Biol, Kingston, ON K7L 3N6, Canada. [Brumfield, Terrell; Yost, Jerry; Kambhampati, Murty] Southern Univ New Orleans, Dept Nat Sci, New Orleans, LA 70126 USA. [Wilkinson, Jeremy E.] Res & Testing Lab, Lubbock, TX 79407 USA. RP Shah, V (reprint author), West Chester Univ, Coll Sci & Math, W Chester, PA 19382 USA. EM vshah@wcupa.edu RI BM, MRCAT/G-7576-2011 FU National Science Foundation grant [966741]; Natural Sciences and Engineering Research Council (Discovery; Canada); NSF of Southern University at New Orleans [HRD - 0928797]; Department of Energy (DOE); DOE Office of Science by Argonne National Laboratory [DE-AC02-06CH11357] FX The work was funded by National Science Foundation grant # 966741 to VS and Natural Sciences and Engineering Research Council (Discovery; Canada) to VKW. TB and JY were sponsored by an NSF funded HBCU-UP E3MaS grant HRD - 0928797 of Southern University at New Orleans. This work has been subjected to EPA administrative review and approved for publication. Any opinions expressed in this paper are those of the author(s) and do not, necessarily, reflect the official positions and policies of the USEPA or the funding agencies. Any mention of the products or trade names does not constitute recommendations for use by the USEPA. The Advanced Photon Source (APS, Argonne, Illinois, USA) is acknowledged for the allocation of beam time. MRCAT operations are supported by the Department of Energy (DOE) and the MRCAT member institutions. This research used resources of the Advanced Photon Source, a U.S. DOE Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under Contract No. DE-AC02-06CH11357. NR 42 TC 0 Z9 0 U1 7 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD DEC 15 PY 2016 VL 573 BP 661 EP 670 DI 10.1016/j.scitotenv.2016.08.114 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA EF1FP UT WOS:000390071000062 PM 27585433 ER PT J AU Bruno, M Ross, J Ge, Y AF Bruno, Maribel Ross, Jeffrey Ge, Yue TI Proteomic responses of BEAS-2B cells to nontoxic and toxic chromium: Protein indicators of cytotoxicity conversion SO TOXICOLOGY LETTERS LA English DT Article DE Chromium; Protein expression and phosphorylation; Proteomics; Cytotoxicity; Metals; ELISA; Pathways; Mode of action ID LUNG EPITHELIAL-CELLS; UBIQUITIN-PROTEASOME SYSTEM; HEXAVALENT CHROMIUM; IN-VITRO; MOLECULAR-MECHANISMS; AEROBIC GLYCOLYSIS; EXPRESSION; CANCER; AKT; PHOSPHORYLATION AB Hexavalent chromium (Cr (VI)) is an environmental human carcinogen which primarily targets lungs. Among a variety of toxic mechanisms, disruption of biological pathways via translational and posttranslational modifications represents a key mechanism through which Cr (VI) induces cytotoxicity and carcinogenesis. To identify those disruptions which are altered in response to cytotoxic Cr (VI) exposures, we measured and compared cytotoxicity and changes in expression and phosphorylation status of 15 critical biochemical pathway regulators in human BEAS-2B cells exposed for 48 h to a non-toxic concentration (0.3 mu M) and a toxic concentration (1.8 mM) of Cr (VI) by ELISA techniques. In addition, 43 functional proteins which may be altered in response to pathway signaling changes were identified using two dimensional electrophoresis (2-DE) and mass spectrometry. The proteins and fold changes observed in cells exposed to the non-toxic dose of Cr (VI) (0.3 mM) were not necessarily the same as those found in the toxic one (1.8 mM). A subset of signaling proteins that were correlated with the cytotoxic responses of human BEAS-2B cells to Cr (VI) treatments were identified. These proteins include regulators of glycolysis, glycogen synthase kinase 3 beta (GSK3) and phosphoprotein 70 ribosomal protein s6 kinase (p70S6K), a signaling protein associated with oxidative stress and inflammation responses, JNK and metal regulatory transcription factor 1 (MTF-1), and a source of ubiquitin for signaling targeted protein degradation, polyubiquitin C (UBC). In addition, two dimensional gel electrophoresis (2-DE) was applied to identify key alterations in biochemical pathways differentiating between cytotoxic and non-cytotoxic exposures to Cr (VI), including glycolysis and gluconeogenesis, protein degradation, inflammation, and oxidative stress. Published by Elsevier Ireland Ltd. C1 [Bruno, Maribel; Ross, Jeffrey; Ge, Yue] US EPA, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. RP Ge, Y (reprint author), US EPA, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. EM ge.yue@epa.gov OI Ross, Jeffrey/0000-0002-7002-4548 FU US Environmental Protection Agency FX The authors would like to thank Dr. Brian Chorley and Dr. Medhi Hazari for their very helpful comments on this manuscript. The information in this document has been funded wholly by the US Environmental Protection Agency. It has been subjected to review by the National Health and Environmental Effects Research Laboratory and approved for publication. Approval does not signify that the contents reflect the views of the Agency nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 49 TC 0 Z9 0 U1 4 U2 4 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0378-4274 EI 1879-3169 J9 TOXICOL LETT JI Toxicol. Lett. PD DEC 15 PY 2016 VL 264 BP 59 EP 70 DI 10.1016/j.toxlet.2016.08.025 PG 12 WC Toxicology SC Toxicology GA EF7DB UT WOS:000390489200007 PM 27592090 ER PT J AU Moser, VC Liu, ZW Schlosser, C Spanogle, TL Chandrasekaran, A McDaniel, KL AF Moser, Virginia C. Liu, Zhiwei Schlosser, Christopher Spanogle, Terri L. Chandrasekaran, Appavu McDaniel, Katherine L. TI Locomotor activity and tissue levels following acute administration of lambda- and gamma-cyhalothrin in rats SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article DE Cyhalothrin; Pyrethroids; Neurotoxicity; Motor activity; Toxicokinetics ID PYRETHROID INSECTICIDES; MOTOR-ACTIVITY; PHARMACOKINETIC MODEL; BRAIN LEVELS; DELTAMETHRIN; PERMETHRIN; NEUROTOXICITY; TOXICITY; TOXICOKINETICS; BIORESMETHRIN AB Pyrethroids produce neurotoxicity that depends, in part, on the chemical structure. Common behavioral effects include locomotor activity changes and specific toxic syndromes (types I and II). In general these neurobehavioral effects correlate well with peak internal dose metrics. Products of cyhalothrin, a type II pyrethroid, include mixtures of isomers (e.g., lambda-cyhalothrin) as well as enriched active isomers (e.g., gamma-cyhalothrin). We measured acute changes in locomotor activity in adult male rats and directly correlated these changes to peak brain and plasma concentrations of lambda- and gamma-cyhalothrin using a within-subject design. One-hour locomotor activity studies were conducted 1.5 h after oral gavage dosing, and immediately thereafter plasma and brains were collected for analyzing tissue levels using LC/MS/MS methods. Both isomers produced dose-related decreases in activity counts, and the effective dose range for gamma-cyhalothrin was lower than for lambda-cyhalothrin. Doses calculated to decrease activity by 50% were 2-fold lower for the gamma-isomer (1.29 mg/kg) compared to lambda-cyhalothrin (2.65 mg/kg). Salivation, typical of type II pyrethroids, was also observed at lower doses of gamma-cyhalothrin. Administered dose correlated well with brain and plasma concentrations, which furthermore showed good correlations with activity changes. Brain and plasma levels were tightly correlated across doses. While gamma-cyhalothrin was 2-fold more potent based on administered dose, the differences based on internal concentrations were less, with gamma-cyhalothrin being 1.3- to 1.6-fold more potent than lambda-cyhalothrin. These potency differences are consistent with the purity of the lambda-isomer (approximately 43%) compared to the enriched isomer gamma-cyhalothrin (approximately 98%). Thus, administered dose as well as differences in cyhalothrin isomers is a good predictor of behavioral effects. Published by Elsevier Inc. C1 [Moser, Virginia C.; McDaniel, Katherine L.] US EPA, Tox Assessment Div, Natl Hlth Effects & Environm Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Liu, Zhiwei; Spanogle, Terri L.; Chandrasekaran, Appavu] FMC Corp, Princeton South Corp Ctr 701, Ewing, NJ USA. [Schlosser, Christopher] US EPA, Div Hlth Effects, Off Pesticide Programs, Off Chem Safety & Pollut Prevent, Washington, DC 20460 USA. RP Moser, VC (reprint author), US EPA, Tox Assessment Div MD B105-04, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM Moser.ginger@epa.gov FU intramural research program of the Office of Research and Development US EPA; FMC Corporation FX The in vivo research was funded via the intramural research program of the Office of Research and Development US EPA, and all analytical work was funded by FMC Corporation. NR 28 TC 0 Z9 0 U1 7 U2 7 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0041-008X EI 1096-0333 J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD DEC 15 PY 2016 VL 313 BP 97 EP 103 DI 10.1016/j.taap.2016.10.020 PG 7 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA EE8IK UT WOS:000389868700010 PM 27794438 ER PT J AU Humayun, MT Divan, R Stan, L Rosenmann, D Gosztola, D Gundel, L Solomon, PA Paprotny, I AF Humayun, Md Tanim Divan, Ralu Stan, Liliana Rosenmann, Daniel Gosztola, David Gundel, Lara Solomon, Paul A. Paprotny, Igor TI Ubiquitous Low-Cost Functionalized Multi-Walled Carbon Nanotube Sensors for Distributed Methane Leak Detection SO IEEE SENSORS JOURNAL LA English DT Article DE Methane; carbon nanotube; chemoresistor ID GAS SENSOR AB This paper presents a highly sensitive, energy efficient, and low-cost distributed methane (CH4) sensor system (DMSS) for continuous monitoring, detection, and localization of CH4 leaks in natural gas infrastructure, such as transmission and distribution pipelines, wells, and production pads. The CH4 sensing element, a key component of the DMSS, consists of a metal-oxide nanocrystal functionalized multi-walled carbon nanotube mesh, which, in comparison with the existing literature, shows stronger relative resistance change while interacting with lower parts per million concentration of CH4. A Gaussian plume triangulation algorithm has been developed for the DMSS. Given a geometric model of the surrounding environment, the algorithm can precisely detect and localize a CH4 leak as well as estimate its mass emission rate. A UV-based surface recovery technique making the sensor recover ten times faster than the reported ones is presented for the DMSS. A control algorithm based on the UV-accelerated recovery is developed, which facilitates faster leak detection. C1 [Humayun, Md Tanim; Paprotny, Igor] Univ Illinois, Dept Elect & Comp Engn, Chicago, IL 60607 USA. [Divan, Ralu; Stan, Liliana; Rosenmann, Daniel; Gosztola, David] Argonne Natl Lab, Ctr Nanoscale Mat, Lemont, IL 60439 USA. [Gundel, Lara] Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA. [Solomon, Paul A.] US EPA, Las Vegas, NV 89119 USA. RP Humayun, MT (reprint author), Univ Illinois, Dept Elect & Comp Engn, Chicago, IL 60607 USA. EM mhumay2@uic.edu; divan@anl.gov; lstan@anl.gov; rosenmann@anl.gov; gosztola@anl.gov; lagundel@lbl.gov; solomon.paul@epa.gov; paprotny@uic.edu FU Center for Nanoscale Materials, Argonne National Laboratory, an Office of Science user facility; U. S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-06CH11357]; College of Engineering, University of Illinois, Chicago, IL; Aclima Inc. [2015-07496] FX This work was supported in part by the Center for Nanoscale Materials, Argonne National Laboratory, an Office of Science user facility, was supported by the U. S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract DE-AC02-06CH11357. The project is in part funded by the College of Engineering, University of Illinois, Chicago, IL, and by a Grant from Aclima Inc., under Award 2015-07496. NR 26 TC 0 Z9 0 U1 10 U2 10 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1530-437X EI 1558-1748 J9 IEEE SENS J JI IEEE Sens. J. PD DEC 15 PY 2016 VL 16 IS 24 BP 8692 EP 8699 DI 10.1109/JSEN.2016.2581832 PG 8 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA ED7NU UT WOS:000389053900005 ER PT J AU Rizzo, E Bardos, P Pizzol, L Critto, A Giubilato, E Marcomini, A Albano, C Darmendrail, D Doberl, G Harclerode, M Harries, N Nathanail, P Pachon, C Rodriguez, A Slenders, H Smith, G AF Rizzo, Erika Bardos, Paul Pizzol, Lisa Critto, Andrea Giubilato, Elisa Marcomini, Antonio Albano, Claudio Darmendrail, Dominique Doberl, Gernot Harclerode, Melissa Harries, Nicola Nathanail, Paul Pachon, Carlos Rodriguez, Alfonso Slenders, Hans Smith, Garry TI Comparison of international approaches to sustainable remediation SO JOURNAL OF ENVIRONMENTAL MANAGEMENT LA English DT Article DE Sustainable remediation; Sustainable brownfield regeneration; Green remediation; Sustainability appraisal; Sustainable remediation approaches; comparison; Sustainable remediation trends ID PRINCIPLES; BROWNFIELD; MANAGEMENT AB Since mid-to-late 2000s growing interest for sustainable remediation has emerged in initiatives from several international and national organisations as well as other initiatives from networks and forums. This reflects a realisation that risk-management activities can about bring environmental, social, and economic impacts (positive or negative) in addition to achieving risk-based remediation goals. These ideas have begun to develop as a new discipline of "sustainable remediation". The various initiatives have now published a number of frameworks, standards, white papers, road maps and operative guidelines. The similarities and differences in the approaches by these outputs and general trends have been identified. The comparison is based on a set of criteria developed in discussion with members of these various initiatives, and identifies a range of similarities between their publications. Overall the comparison demonstrates a high level of consensus across definitions and principles, which leads to the conclusion that there is a shared understanding of what sustainable remediation is both across countries and stakeholder groups. Publications do differ in points of detail, in particular about the operational aspects of sustainable remediation assessment. These differences likely result from differences in context and legal framework. As this analysis was carried out its findings were debated with members of the various international initiatives, many of whom have been included as authors. Hence the outcomes described in this paper can be seen as the result of a sort of multi-level debate among international experts (authors) and so can offer a starting point to new sustainable remediation initiatives (for example in other countries) that aim to start developing their own documents. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Rizzo, Erika; Pizzol, Lisa; Critto, Andrea; Giubilato, Elisa; Marcomini, Antonio] Univ Ca Foscari Venice, Dept Environm Sci Informat & Stat, Via Ind 21-8,INCA VEGAPK, I-30175 Marghera Venice, Italy. [Bardos, Paul] Univ Brighton, Brighton, E Sussex, England. [Bardos, Paul] R3 Environm Technol Ltd, Reading, Berks, England. [Albano, Claudio] CH2MHILL, Via 25 Aprile 2, I-20097 San Donato Milanese, Mi, Italy. [Albano, Claudio] SuRF Italy RECONNET, Ispra, Italy. [Darmendrail, Dominique] Common Forum Contaminated Land Europe, Paris, France. [Doberl, Gernot] Environm Agcy Austria, Dept Contaminated Sites, Vienna, Austria. [Harclerode, Melissa] Montclair State Univ, Montclair, NJ 07043 USA. [Harclerode, Melissa] CDM Smith, Edison, NJ USA. [Nathanail, Paul] Univ Nottingham, Nottingham, England. [Nathanail, Paul] Land Qual Management Ltd, Nottingham, England. [Pachon, Carlos] US EPA, Washington, DC 20460 USA. [Rodriguez, Alfonso] R3 Environm Technol Colombia SAS, Bogota, Colombia. [Slenders, Hans] NICOLE Secretariat, Network Ind Contaminated Land Europe, POB 28249, NL-3003 KE Rotterdam, Netherlands. [Slenders, Hans] ARCADIS Nederland BV, Arnhem, Netherlands. [Smith, Garry] SuRF Australia, Geosyntec Consultants, Dunedin, New Zealand. RP Critto, A (reprint author), Univ Ca Foscari Venice, Dept Environm Sci Informat & Stat, Via Ind 21-8,INCA VEGAPK, I-30175 Marghera Venice, Italy. EM critto@unive.it RI Pizzol, Lisa/R-5149-2016 FU European Commission's Seventh Framework Programme [265364]; University of Brighton, UK FX The authors gratefully acknowledge the receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the European Commission's Seventh Framework Programme in the theme ENV.2010.3.1.5-2-Environmental technologies for brownfield regeneration (Grant agreement no. 265364) - project TIMBRE - www.timbre-project.eu. Paul Bardos' contribution was supported by the University of Brighton, UK. NR 48 TC 0 Z9 0 U1 6 U2 6 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0301-4797 EI 1095-8630 J9 J ENVIRON MANAGE JI J. Environ. Manage. PD DEC 15 PY 2016 VL 184 SI SI BP 4 EP 17 DI 10.1016/j.jenvman.2016.07.062 PN 1 PG 14 WC Environmental Sciences SC Environmental Sciences & Ecology GA ED0QP UT WOS:000388547300002 PM 27520125 ER PT J AU Nahlik, AM Fennessy, MS AF Nahlik, A. M. Fennessy, M. S. TI Carbon storage in US wetlands SO NATURE COMMUNICATIONS LA English DT Article ID SEQUESTRATION; STREAMS; BALANCE; REGION AB Wetland soils contain some of the highest stores of soil carbon in the biosphere. However, there is little understanding of the quantity and distribution of carbon stored in our remaining wetlands or of the potential effects of human disturbance on these stocks. Here we use field data from the 2011 National Wetland Condition Assessment to provide unbiased estimates of soil carbon stocks for wetlands at regional and national scales. We find that wetlands in the conterminous United States store a total of 11.52 PgC, much of which is within soils deeper than 30 cm. Freshwater inland wetlands, in part due to their substantial areal extent, hold nearly ten-fold more carbon than tidal saltwater sites-indicating their importance in regional carbon storage. Our data suggest a possible relationship between carbon stocks and anthropogenic disturbance. These data highlight the need to protect wetlands to mitigate the risk of avoidable contributions to climate change. C1 [Nahlik, A. M.; Fennessy, M. S.] Kenyon Coll, Dept Biol, 202 N Coll Rd, Gambier, OH 43022 USA. [Nahlik, A. M.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Lab, Western Ecol Div, 200 SW 35th St, Corvallis, OR 97333 USA. RP Nahlik, AM; Fennessy, MS (reprint author), Kenyon Coll, Dept Biol, 202 N Coll Rd, Gambier, OH 43022 USA.; Nahlik, AM (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Lab, Western Ecol Div, 200 SW 35th St, Corvallis, OR 97333 USA. EM nahlik.amanda@epa.gov; fennessym@kenyon.edu FU United States Environmental Protection Agency (USEPA) [83422601]; Michigan State University FX We thank J.R. Brooks, M.E. Kentula and T.K. Magee for discussions and comments on the manuscript, K. Blocksom, J.B. Moon, T. Kincaid and S. Jalabert, who provided scripting assistance in R, and M. Fillmore and C. Owens for their guidance on soil taxonomy. Funding for A.M.N. and M.S.F. was provided by the United States Environmental Protection Agency (USEPA) cooperative agreement number 83422601 with Michigan State University to Kenyon College. Research was planned by the USEPA and performed by cooperating States and Tribes as part of the 2011 National Wetland Condition Assessment. NR 42 TC 0 Z9 0 U1 24 U2 24 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2041-1723 J9 NAT COMMUN JI Nat. Commun. PD DEC 13 PY 2016 VL 7 AR 13835 DI 10.1038/ncomms13835 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EE5TR UT WOS:000389671100001 PM 27958272 ER PT J AU Reid, NM Proestou, DA Clark, BW Warren, WC Colbourne, JK Shaw, JR Karchner, SI Hahn, ME Nacci, D Oleksiak, MF Crawford, DL Whitehead, A AF Reid, Noah M. Proestou, Dina A. Clark, Bryan W. Warren, Wesley C. Colbourne, John K. Shaw, Joseph R. Karchner, Sibel I. Hahn, Mark E. Nacci, Diane Oleksiak, Marjorie F. Crawford, Douglas L. Whitehead, Andrew TI The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish SO SCIENCE LA English DT Article ID KILLIFISH FUNDULUS-HETEROCLITUS; ATLANTIC KILLIFISH; GENETIC-VARIATION; CRUDE-OIL; RECEPTOR; POPULATIONS; TOLERANCE; GROWTH; PCBS; LOCI AB Atlantic killifish populations have rapidly adapted to normally lethal levels of pollution in four urban estuaries. Through analysis of 384 whole killifish genome sequences and comparative transcriptomics in four pairs of sensitive and tolerant populations, we identify the aryl hydrocarbon receptor-based signaling pathway as a shared target of selection. This suggests evolutionary constraint on adaptive solutions to complex toxicant mixtures at each site. However, distinct molecular variants apparently contribute to adaptive pathway modification among tolerant populations. Selection also targets other toxicity-mediating genes and genes of connected signaling pathways; this indicates complex tolerance phenotypes and potentially compensatory adaptations. Molecular changes are consistent with selection on standing genetic variation. In killifish, high nucleotide diversity has likely been a crucial substrate for selective sweeps to propel rapid adaptation. C1 [Reid, Noah M.; Whitehead, Andrew] Univ Calif Davis, Dept Environm Toxicol, Davis, CA 95616 USA. [Proestou, Dina A.] USDA ARS, Kingston, RI 02881 USA. [Clark, Bryan W.] US EPA, Oak Ridge Inst Sci & Educ, Off Res & Dev, Narragansett, RI 02882 USA. [Warren, Wesley C.] Washington Univ, Sch Med, McDonnell Genome Inst, St Louis, MO 63108 USA. [Colbourne, John K.; Shaw, Joseph R.] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England. [Shaw, Joseph R.] Indiana Univ, Sch Publ & Environm Affairs, Bloomington, IN 47405 USA. [Karchner, Sibel I.; Hahn, Mark E.] Woods Hole Oceanog Inst, Dept Biol, Woods Hole, MA 02543 USA. [Karchner, Sibel I.; Hahn, Mark E.] Boston Univ, Superfund Res Program, Boston, MA 02118 USA. [Nacci, Diane] US EPA, Off Res & Dev, Narragansett, RI 02882 USA. [Oleksiak, Marjorie F.; Crawford, Douglas L.] Univ Miami, Rosenstiel Sch Marine & Atmospher Sci, Dept Marine Biol & Ecol, 4600 Rickenbacker Causeway, Miami, FL 33149 USA. RP Whitehead, A (reprint author), Univ Calif Davis, Dept Environm Toxicol, Davis, CA 95616 USA. EM awhitehead@ucdavis.edu FU National Center for Biotechnology Information [PRJNA323589]; NSF [DEB-1265282, DEB-112052, DEB-1120013, DEB-1120263, DEB-1120333, DEB-1120398]; National Institutes of Environmental Health Sciences [1R01ES021934-01, P42ES007381, R01ES019324]; National Science Foundation [OCE-1314567]; Postdoctoral Research Program at the U.S. Environmental Protection Agency (EPA) [DW92429801] FX Sequence data are archived at the National Center for Biotechnology Information (BioProject PRJNA323589). Phylogenetic tree data are archived at Dryad (doi: 10.5061/dryad.68n87). We thank G. Coop, B. Counterman, D. Champlin, I. Kirby, and A. Bertrand for their valuable input. Primary support was from the NSF (collaborative research grants DEB-1265282, DEB-112052, DEB-1120013, DEB-1120263, DEB-1120333, DEB-1120398 to J.K.C., D.L.C., M.E.H., S.I.K., M.F.O., J.R.S., W.C.W. and A.W.). Further support was provided by the National Institutes of Environmental Health Sciences (1R01ES021934-01 to A.W.; P42ES007381 to M.E.H.; R01ES019324 to J.R.S.), and the National Science Foundation (OCE-1314567 to A.W.). B.W.C. as supported by the Postdoctoral Research Program at the U.S. Environmental Protection Agency (EPA) administered by the Oak Ridge Institute for Science and Education (agreement DW92429801). The views expressed in this article are those of the authors and do not necessarily represent the views or policies of the EPA. NR 24 TC 3 Z9 3 U1 43 U2 43 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 EI 1095-9203 J9 SCIENCE JI Science PD DEC 9 PY 2016 VL 354 IS 6317 BP 1305 EP 1308 DI 10.1126/science.aah4993 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EE4TS UT WOS:000389598800064 PM 27940876 ER PT J AU Almaliti, J Al-Hamashi, AA Negmeldin, AT Hanigan, CL Perera, L Pflum, MKH Casero, RA Tillekeratne, LMV AF Almaliti, Jehad Al-Hamashi, Ayad A. Negmeldin, Ahmed T. Hanigan, Christin L. Perera, Lalith Pflum, Mary Kay H. Casero, Robert A., Jr. Tillekeratne, L. M. Viranga TI Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID HISTONE DEACETYLASE INHIBITORS; HDAC ISOFORM SELECTIVITY; BIOLOGICAL EVALUATION; RHEUMATOID-ARTHRITIS; CANCER; RECOGNITION; EXPRESSION; DISORDERS; DISCOVERY; THERAPY AB A number of analogues of the marine-derived histone deacetylase inhibitor largazole incorporating major structural changes in the depsipeptide ring were synthesized. Replacing the thiazole-thiazoline fragment of largazole with a bipyridine group gave analogue 7 with potent cell growth inhibitory activity and an activity profile similar to that of largazole, suggesting that conformational change accompanying switching hybridization from sp(3) to sp(2) at C-7 is well tolerated. Analogue 7 was more class I selective compared to largazole, with at least 464-fold selectivity for class I HDAC proteins over class II HDAC6 compared to a 22-fold selectivity observed with largazole. To our knowledge 7 represents the first example of a potent and highly cytotoxic largazole analogue not containing a thiazoline ring. The elimination of a chiral center derived from the unnatural amino acid R-a-methylcysteine makes the molecule more amenable to chemical synthesis, and coupled with its increased class I selectivity, 7 could serve as a new lead compound for developing selective largazole analogues. C1 [Almaliti, Jehad; Al-Hamashi, Ayad A.; Tillekeratne, L. M. Viranga] Univ Toledo, Dept Med & Biol Chem, Coll Pharm & Pharmaceut Sci, 2801 W Bancroft St, Toledo, OH 43606 USA. [Almaliti, Jehad] Univ Jordan, Dept Pharmaceut Sci, Fac Pharm, Amman 11942, Jordan. [Negmeldin, Ahmed T.; Pflum, Mary Kay H.] Wayne State Univ, Dept Chem, 5101 Cass Ave, Detroit, MI 48202 USA. [Hanigan, Christin L.; Casero, Robert A., Jr.] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Bunting Blaustein Canc Res Bldg 1,Room 551, Baltimore, MD 21231 USA. [Perera, Lalith] Natl Inst Environm Hlth Sci, Lab Struct Biol, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC 27709 USA. RP Tillekeratne, LMV (reprint author), Univ Toledo, Dept Med & Biol Chem, Coll Pharm & Pharmaceut Sci, 2801 W Bancroft St, Toledo, OH 43606 USA. EM ltillek@utnet.utoledo.edu OI Negmeldin, Ahmed/0000-0003-3399-3435 FU National Institutes of Health, National Institute of Environmental Health Sciences [Z01-ES043010]; NIH [CA051085] FX This research was supported in part by the Intramural Research Program of the National Institutes of Health, National Institute of Environmental Health Sciences Grant Z01-ES043010 (to L.P.), and NIH Grant CA051085 (to R.A.C.). NR 54 TC 0 Z9 0 U1 5 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 EI 1520-4804 J9 J MED CHEM JI J. Med. Chem. PD DEC 8 PY 2016 VL 59 IS 23 BP 10642 EP 10660 DI 10.1021/acs.jmedchem.6b01271 PG 19 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA EE5DB UT WOS:000389623900019 PM 27809521 ER PT J AU Davis, MJ Janke, R Taxon, TN AF Davis, Michael J. Janke, Robert Taxon, Thomas N. TI Assessing Inhalation Exposures Associated with Contamination Events in Water Distribution Systems SO PLOS ONE LA English DT Article ID VOLATILE ORGANIC-COMPOUNDS; CHLORINATED TAP WATER; DRINKING-WATER; SIZE DISTRIBUTION; DISTRIBUTION NETWORK; CHLOROFORM EXPOSURE; ESCHERICHIA-COLI; SENSOR PLACEMENT; HOME HUMIDIFIERS; SHOWER WATER AB When a water distribution system (WDS) is contaminated, short-term inhalation exposures to airborne contaminants could occur as the result of domestic water use. The most important domestic sources of such exposures are likely to be showering and the use of aerosol-producing humidifiers, i.e., ultrasonic and impeller (cool-mist) units. A framework is presented for assessing the potential effects of short-term, system-wide inhalation exposures that could result from such activities during a contamination event. This framework utilizes available statistical models for showering frequency and duration, available exposure models for showering and humidifier use, and experimental results on both aerosol generation and the volatilization of chemicals during showering. New models for the times when showering occurs are developed using time-use data for the United States. Given a lack of similar models for how humidifiers are used, or the information needed to develop them, an analysis of the sensitivity of results to assumptions concerning humidifier use is presented. The framework is applied using network models for three actual WDSs. Simple models are developed for estimating upper bounds on the potential effects of system-wide inhalation exposures associated with showering and humidifier use. From a system-wide, population perspective, showering could result in significant inhalation doses of volatile chemical contaminants, and humidifier use could result in significant inhalation doses of microbial contaminants during a contamination event. From a system-wide perspective, showering is unlikely to be associated with significant doses of microbial contaminants. Given the potential importance of humidifiers as a source of airborne contaminants during a contamination event, an improved understanding of the nature of humidifier use is warranted. C1 [Davis, Michael J.] Argonne Natl Lab, Div Environm Sci, Argonne Associate Seville, 9700 S Cass Ave, Argonne, IL 60439 USA. [Janke, Robert] US EPA, Natl Homeland Secur Res Ctr, Cincinnati, OH 45268 USA. [Taxon, Thomas N.] Argonne Natl Lab, Global Secur Sci Div, 9700 S Cass Ave, Argonne, IL 60439 USA. RP Davis, MJ (reprint author), Argonne Natl Lab, Div Environm Sci, Argonne Associate Seville, 9700 S Cass Ave, Argonne, IL 60439 USA.; Janke, R (reprint author), US EPA, Natl Homeland Secur Res Ctr, Cincinnati, OH 45268 USA. EM mike_davis@anl.gov; janke.robert@epa.gov FU U.S. Environmental Protection Agency through U.S. Department of Energy [DE-AC02-06CH11357] FX Work at Argonne National Laboratory was sponsored by the U.S. Environmental Protection Agency under interagency agreement through U.S. Department of Energy Contract DE-AC02-06CH11357. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 72 TC 0 Z9 0 U1 3 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 8 PY 2016 VL 11 IS 12 AR e0168051 DI 10.1371/journal.pone.0168051 PG 41 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EE4OA UT WOS:000389580900074 PM 27930709 ER PT J AU Chen, Y Hermens, JLM Jonker, MTO Arnot, JA Armitage, JM Brown, T Nichols, JW Fay, KA Droge, STJ AF Chen, Yi Hermens, Joop L. M. Jonker, Michiel T. O. Arnot, Jon A. Armitage, James M. Brown, Trevor Nichols, John W. Fay, Kellie A. Droge, Steven T. J. TI Which Molecular Features Affect the Intrinsic Hepatic Clearance Rate of Ionizable Organic Chemicals in Fish? SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID TROUT ONCORHYNCHUS-MYKISS; IN-VITRO BIOTRANSFORMATION; LIVER S9 FRACTIONS; METABOLISM DATA; ALKYLBENZENE SULFONATE; BIOACCUMULATION MODEL; PERFLUOROALKYL ACIDS; SERUM-ALBUMIN; CLAY-MINERALS; HALF-LIVES AB Greater knowledge of biotransformation rates for ionizable organic compounds (IOCs) in fish is required to properly assess the bioaccumulation potential of many environmentally relevant contaminants. In this study, we measured in vitro hepatic clearance rates for SO IOCs using a pooled batch of liver S9 fractions isolated from rainbow trout (Oncorhynchus mykiss). The IOCs included four types of strongly ionized acids (carboxylates, phenolates, sulfonates, and sulfates), three types of strongly ionized bases (primary, secondary, tertiary amines), and a pair of quaternary ammonium compounds (QACs). Included in this test set were several surfactants and a series of beta-blockers. For linear alkyl chain IOC analogues, biotransformation enzymes appeared to act directly on the charged terminal group, with the highest clearance rates for tertiary amines and sulfates and no clearance of QACs. Clearance rates for C-12-IOCs were higher than those for C-8-IOC analogues. Several analogue series with multiple alkyl chains, branched alkyl chains, aromatic rings, and nonaromatic rings were evaluated. The likelihood of multiple reaction pathways made it difficult to relate all differences in clearance to specific molecular features the tested IOCs. Future analysis of primary metabolites in the S9 assay is recommended to further elucidate biotransformation pathways for IOCs in fish. C1 [Chen, Yi; Hermens, Joop L. M.; Jonker, Michiel T. O.; Droge, Steven T. J.] Univ Utrecht, Inst Risk Assessment Sci, NL-3508 TD Utrecht, Netherlands. [Arnot, Jon A.; Armitage, James M.] Univ Toronto Scarborough, Dept Phys & Environm Sci, Toronto, ON M1C 1A4, Canada. [Arnot, Jon A.; Armitage, James M.; Brown, Trevor] ARC, Toronto, ON M4M 1W4, Canada. [Nichols, John W.; Fay, Kellie A.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA. [Droge, Steven T. J.] UvA IBED, Postbus 94248, NL-1090 GE Amsterdam, Netherlands. RP Droge, STJ (reprint author), Univ Utrecht, Inst Risk Assessment Sci, NL-3508 TD Utrecht, Netherlands.; Droge, STJ (reprint author), UvA IBED, Postbus 94248, NL-1090 GE Amsterdam, Netherlands. EM steven.droge@gmail.com FU European Chemical Industry Council's Long-range Research Initiative program (Cefic-LRI) as part of the ECO21 project FX This research was financially supported by the European Chemical Industry Council's Long-range Research Initiative program (Cefic-LRI) as part of the ECO21 project. The European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) is acknowledged for managing the project, and discussions with various ECETOC monitoring team members were highly appreciated. NR 67 TC 1 Z9 1 U1 14 U2 14 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD DEC 6 PY 2016 VL 50 IS 23 BP 12722 EP 12731 DI 10.1021/acs.est.6b03504 PG 10 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA EE4FG UT WOS:000389557100023 PM 27934284 ER PT J AU Lee, HS Dhar, BR An, J Rittmann, BE Ryu, H Domingo, JWS Ren, H Chae, J AF Lee, Hyung-Sool Dhar, Bipro Ranjan An, Junyeong Rittmann, Bruce E. Ryu, Hodon Domingo, Jorge W. Santo Ren, Hao Chae, Junseok TI The Roles of Biofilm Conductivity and Donor Substrate Kinetics in a Mixed-Culture Biofilm Anode SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID MICROBIAL FUEL-CELLS; EXTRACELLULAR ELECTRON-TRANSFER; GEOBACTER-SULFURREDUCENS BIOFILMS; C-TYPE CYTOCHROME; ELECTRICITY-GENERATION; RESPIRING BACTERIA; SP NOV.; MODEL; COMMUNITIES; TRANSPORT AB We experimentally assessed the kinetics and thermodynamics of electron transfer (ET) from the donor substrate (acetate) to the anode for a mixed-culture biofilm anode. We interpreted the results with a modified biofilm-conduction model consisting of three ET steps in series: (1) intracellular ET, (2) non-Ohmic extracellular ET (EET) from an outer membrane protein to an extracellular cofactor (EC), and (3) ET from the EC to the anode by Ohmic-conduction in the biofilm matrix. The steady-state current density was 0.82 +/- 0.03 A/m(2) in a miniature microbial electrochemical cell operated at fixed anode potential of -0.15 V versus the standard hydrogen electrode. Illumina 16S-rDNA and-rRNA sequences showed that the Geobacter genus was less than 30% of the community of the biofilm anode. Biofilm conductivity was high at 2.44 +/- 0.42 mS/cm, indicating that the maximum current density could be as high as 270 A/m(2) if only Ohmic-conduction EET was limiting. Due to the high biofilm conductivity, the maximum energy loss for Ohmic-conduction EET was negligible, 0.085 mV. The energy loss in the second ET step also was small, only 20 mV, and the potential for the EC involved in the second ET was -0.15 V, a value documenting that >99% of the EC was in the oxidized state. Monod kinetics for utilization of acetate were relatively slow, and at least 87% of the energy loss was in the intracellular step. Thus, intracellular ET was the main kinetic and thermodynamic bottleneck to ET from donor substrate to the anode for a highly conductive biofilm. C1 [Lee, Hyung-Sool; Dhar, Bipro Ranjan; An, Junyeong] Univ Waterloo, Dept Civil & Environm Engn, 200 Univ Ave West, Waterloo, ON N2L 3G1, Canada. [Rittmann, Bruce E.] Arizona State Univ, Biodesign Inst, Swette Ctr Environm Biotechnol, POB 875701, Tempe, AZ 85287 USA. [Ryu, Hodon; Domingo, Jorge W. Santo] US EPA, Natl Risk Management Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. [Ren, Hao; Chae, Junseok] Arizona State Univ, Sch Elect Comp & Energy Engn, Tempe, AZ 85287 USA. RP Lee, HS (reprint author), Univ Waterloo, Dept Civil & Environm Engn, 200 Univ Ave West, Waterloo, ON N2L 3G1, Canada. EM hyungsool@uwaterloo.ca FU Natural Sciences and Engineering Research Council of Canada Discovery Grant [RGPIN-2016-04155] FX This research was funded by Natural Sciences and Engineering Research Council of Canada Discovery Grant (RGPIN-2016-04155). NR 68 TC 0 Z9 0 U1 16 U2 16 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD DEC 6 PY 2016 VL 50 IS 23 BP 12799 EP 12807 DI 10.1021/acs.est.6b04168 PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA EE4FG UT WOS:000389557100031 PM 27797183 ER PT J AU Juhasz, AL Scheckel, KG Betts, AR Smith, E AF Juhasz, Albert L. Scheckel, Kirk G. Betts, Aaron R. Smith, Euan TI Predictive Capabilities of in Vitro Assays for Estimating Pb Relative Bioavailability in Phosphate Amended Soils SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID CONTAMINATED SOILS; LEAD BIOACCESSIBILITY; SITU STABILIZATION; MANGANESE OXIDE; PHOSPHORIC-ACID; EXTRACTION TEST; RANGE SOILS; HOUSE-DUST; IMMOBILIZATION; CHLOROPYROMORPHITE AB In this study, the in vitro bioaccessibility (IVBA) of lead (Pb) in phosphate-amended Pb-contaminated soil was assessed using a variety of IVBA assays with an overarching aim of determining whether changes in Pb IVBA were congruent to those observed for Pb relative bioavailability (RBA) determined using an in vivo mouse assay. Amending soil with phosphoric acid or rock phosphate resulted in changes in Pb speciation, however, varying Pb IVBA results were obtained depending on the methodology utilized. In addition, IVBA assays influenced Pb speciation as a consequence of interactions between dissolved Pb and unreacted phosphate arising from the amendment or from assay constituents. When the relationship between Pb RBA and IVBA was assessed, a comparison of treatment effect ratios (Pb RBA or IVBA in treated soil divided by Pb RBA or IVBA for untreated soil) provided the best in vivo in vitro correlation particular for SBRC (r(2) = 0.83) and IVG (r(2) = 0.89) intestinal extraction. For these assays, the slope of the lines of best fit were close to 1 (1.12, 0.82; SBRC, IVG intestinal extraction respectively) with small y-intercepts (0.09, 0.08 respectively) indicating that the efficacy of phosphate amendments for reducing Pb RBA may be predicted using IVBA assays. C1 [Juhasz, Albert L.; Smith, Euan] Univ South Australia, Future Ind Inst, Mawson Lakes, SA 5095, Australia. [Scheckel, Kirk G.; Betts, Aaron R.] US EPA, Natl Risk Management Res Lab, Land Remediat & Pollut Control Div, Cincinnati, OH 45224 USA. [Betts, Aaron R.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37831 USA. RP Juhasz, AL (reprint author), Univ South Australia, Future Ind Inst, Mawson Lakes, SA 5095, Australia. EM Albert.Juhasz@unisa.edu.au RI ID, MRCAT/G-7586-2011 FU Future Industries Institute, University of South Australia; National Risk Management Research Laboratory, U.S. EPA; Oak Ridge Institute for Science and Education; [DE-AC02-06CH11357] FX We acknowledge the support of the Future Industries Institute, University of South Australia, National Risk Management Research Laboratory, U.S. EPA and the Oak Ridge Institute for Science and Education. MRCAT operations are supported by the DOE and the MRCAT member institutions. This research used resources of the APS, a-U.S. DOE Office of Science User Facility operated by Argonne National Laboratory under Contract No. DE-AC02-06CH11357. Although EPA contributed to this article, the research presented was not performed by or funded by EPA and was not subject to EPA's quality system requirements. Consequently, the views, interpretations, and conclusions expressed in this article are solely those of the authors and do not necessarily reflect or represent EPA's views or policies. ARB was supported in part by an appointment the Research Participation Program at the ORD, U.S. EPA, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S DOE and EPA. NR 52 TC 0 Z9 0 U1 10 U2 10 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD DEC 6 PY 2016 VL 50 IS 23 BP 13086 EP 13094 DI 10.1021/acs.est.6b04059 PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA EE4FG UT WOS:000389557100063 PM 27934280 ER PT J AU Maasakkers, JD Jacob, DJ Sulprizio, MP Turner, AJ Weitz, M Wirth, T Hight, C DeFigueiredo, M Desai, M Schmeltz, R Hockstad, L Bloom, AA Bowman, KW Jeong, S Fischer, ML AF Maasakkers, Joannes D. Jacob, Daniel J. Sulprizio, Melissa P. Turner, Alexander J. Weitz, Melissa Wirth, Tom Hight, Cate DeFigueiredo, Mark Desai, Mausami Schmeltz, Rachel Hockstad, Leif Bloom, Anthony A. Bowman, Kevin W. Jeong, Seongeun Fischer, Marc L. TI Gridded National Inventory of US Methane Emissions SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID SPATIALLY EXPLICIT INVENTORY; BARNETT SHALE REGION; UNITED-STATES; SATELLITE DATA; GAS; RETRIEVALS; RESOLUTION; SCIAMACHY; SYSTEM; FLUXES AB We present a gridded inventory of US anthropogenic methane emissions with 0.1 degrees X 0.1 degrees spatial resolution, monthly temporal resolution, and detailed scale-dependent error characterization. The inventory is designed to be consistent with the 2016 US Environmental Protection Agency (EPA) Inventory of US Greenhouse Gas Emissions and Sinks (GHGI) for 2012 The EPA inventory is available only as national totals for different source types. We use a wide range of databases at the state, county, local, and point source level to disaggregate the inventory and allocate the spatial and temporal distribution of emissions for individual source types. Results show large differences with the EDGAR v4.2 global gridded inventory commonly used as a priori estimate in inversions of atmospheric methane observations. We derive grid-dependent error statistics for individual source types from comparison with the Environmental Defense Fund (EDF) regional inventory for Northeast Texas. These error statistics are independently verified by comparison with the California Greenhouse Gas Emissions Measurement (CALGEM) grid-resolved emission inventory. Our gridded, time-resolved inventory provides an improved basis for inversion of atmospheric methane observations to estimate US methane emissions and interpret the results in terms of the underlying processes. C1 [Maasakkers, Joannes D.; Jacob, Daniel J.; Sulprizio, Melissa P.; Turner, Alexander J.] Harvard Univ, Sch Engn & Appl Sci, Pierce Hall,29 Oxford St, Cambridge, MA 02138 USA. [Weitz, Melissa; Wirth, Tom; Hight, Cate; DeFigueiredo, Mark; Desai, Mausami; Schmeltz, Rachel; Hockstad, Leif] US EPA, Climate Change Div, Washington, DC 20460 USA. [Bloom, Anthony A.; Bowman, Kevin W.] CALTECH, Jet Prop Lab, 4800 Oak Grove Dr, Pasadena, CA 91109 USA. [Jeong, Seongeun; Fischer, Marc L.] Lawrence Berkeley Natl Lab, Energy Technol Area, Berkeley, CA 94720 USA. RP Maasakkers, JD (reprint author), Harvard Univ, Sch Engn & Appl Sci, Pierce Hall,29 Oxford St, Cambridge, MA 02138 USA. EM Maasakkers@fas.harvard.edu FU NASA Carbon Monitoring System (CMS); Department of Energy (DOE); NASA; NASA CMS program [NNH13ZDA001N]; California Energy Commission Natural Gas Research Program under U.S. Department of Energy [DE-AC02-05CH11231] FX This research was funded by the NASA Carbon Monitoring System (CMS). A.J. Turner was supported by a Department of Energy (DOE) Computational Science Graduate Fellowship (CSGF). Part of this research was carried out at the Jet Propulsion Laboratory, California Institute of Technology under a contract with NASA. Work by M.L. Fischer and S. Jeong at LBNL was supported by the NASA CMS program (NNH13ZDA001N) and the California Energy Commission Natural Gas Research Program under U.S. Department of Energy Contract No. DE-AC02-05CH11231. We thank D.R. Lyon, D. Zavala-Araiza, and S.P. Hamburg for providing the EDF methane emissions over the Barnett Shale. We thank the anonymous reviewers for their thorough comments. NR 78 TC 3 Z9 3 U1 16 U2 16 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD DEC 6 PY 2016 VL 50 IS 23 BP 13123 EP 13133 DI 10.1021/acs.est.6b02878 PG 11 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA EE4FG UT WOS:000389557100067 PM 27934278 ER PT J AU Willming, MM Lilavois, CR Barron, MG Raimondo, S AF Willming, Morgan M. Lilavois, Crystal R. Barron, Mace G. Raimondo, Sandy TI Acute Toxicity Prediction to Threatened and Endangered Species Using Interspecies Correlation Estimation (ICE) Models (vol 50, pg 10700, 2016) SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Correction C1 [Willming, Morgan M.] US EPA, Oak Ridge Inst Sci & Educ, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA. [Lilavois, Crystal R.; Barron, Mace G.; Raimondo, Sandy] US EPA, Natl Hlth & Environm Effects Lab, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA. RP Willming, MM (reprint author), US EPA, Oak Ridge Inst Sci & Educ, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA. NR 1 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD DEC 6 PY 2016 VL 50 IS 23 BP 13175 EP 13175 DI 10.1021/acs.est.6b05282 PG 1 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA EE4FG UT WOS:000389557100076 PM 27934276 ER PT J AU Leibowitz, SG Mushet, DM Newton, WE AF Leibowitz, Scott G. Mushet, David M. Newton, Wesley E. TI Intermittent Surface Water Connectivity: Fill and Spill Vs. Fill and Merge Dynamics SO WETLANDS LA English DT Article DE Hydrologic connectivity; Geographically isolated wetlands; Prairie potholes; Cottonwood Lake; Water level; Specific conductance; Macroinvertebrate NMS ID GEOGRAPHICALLY ISOLATED WETLANDS; PRAIRIE POTHOLE REGION; HYDROLOGIC CONNECTIVITY; NORTH-DAKOTA; FLOODPLAIN WETLANDS; LANDSCAPE; COMPLEX; PERSPECTIVE; AREA; TERM AB Intermittent surface connectivity can influence aquatic systems, since chemical and biotic movements are often associated with water flow. Although often referred to as fill and spill, wetlands also fill and merge. We examined the effects of these connection types on water levels, ion concentrations, and biotic communities of eight prairie pothole wetlands between 1979 and 2015. Fill and spill caused pulsed surface water connections that were limited to periods following spring snow melt. In contrast, two wetlands connected through fill and merge experienced a nearly continuous, 20-year surface water connection and had completely coincident water levels. Fill and spill led to minimal convergence in dissolved ions and macroinvertebrate composition, while these constituents converged under fill and merge. The primary factor determining differences in response was duration of the surface water connection between wetland pairs. Our findings suggest that investigations into the effects of intermittent surface water connections should not consider these connections generically, but need to address the specific types of connections. In particular, fill and spill promotes external water exports while fill and merge favors internal storage. The behaviors of such intermittent connections will likely be accentuated under a future with more frequent and severe climate extremes. C1 [Leibowitz, Scott G.] US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR 97333 USA. [Mushet, David M.; Newton, Wesley E.] US Geol Survey, Northern Prairie Wildlife Res Ctr, Jamestown, ND 58401 USA. RP Leibowitz, SG (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR 97333 USA. EM leibowitz.scott@epa.gov FU USGS Climate and Land-use Change Mission Area Research and Development Program FX We thank James Jawitz, Brian Neff, and two anonymous reviewers for providing valuable comments that improved this paper. Funding to support maintenance of long-term datasets and associated data collection efforts at the CLSA come from the USGS Climate and Land-use Change Mission Area Research and Development Program. All data used in our analyses are openly available through ScienceBase at https://www.sciencebase.gov/catalog/item/52f0ffd9e4b0f941aa181fc6. This manuscript has been subjected to Agency review and has been approved for publication. The views expressed in this paper are those of the authors and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement or recommendation for use by the U.S. Government. NR 76 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0277-5212 EI 1943-6246 J9 WETLANDS JI Wetlands PD DEC PY 2016 VL 36 SU 2 BP S323 EP S342 DI 10.1007/s13157-016-0830-z PG 20 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA EK7VU UT WOS:000394134100009 ER PT J AU Vanderhoof, MK Alexander, LC AF Vanderhoof, Melanie K. Alexander, Laurie C. TI The Role of Lake Expansion in Altering the Wetland Landscape of the Prairie Pothole Region, United States SO WETLANDS LA English DT Article DE Lakes; Surfacewater; Connectivity; Prairie pothole region; Depressional wetlands; Wetland loss; Landsat; Climate ID NORTH-DAKOTA; SOUTH-DAKOTA; CONNECTIVITY; CLIMATE; SURFACE; PATTERNS; DROUGHT; AREA; TRANSFORMATION; HYDROLOGY AB Interannual variation in lake extent is well documented in the Prairie Pothole Region, but the role of surface-water expansion, including lake expansion, in merging with and subsuming wetlands across the landscape has been minimally considered. We examined how the expansion of surface-water extent, in particular, the expansion of lakes across parts of the Prairie Pothole Region can alter landscape-level hydrologic connectivity among substantial numbers of previously surficially disconnected wetlands. Temporally static wetland, lake, and stream datasets were fused with temporally varying Landsat-derived surface-water extent maps (1990-2011) to quantify changes in surface-water connectivity. Under deluge conditions, lakes were found to create significantly larger complexes of surficially-connected wetlands relative to non-lake surface-water connections (e.g., only wetlands or wetlands and streams). Analysis of three specific lakes showed that lakes can merge with and subsume wetlands located kilometers to tens of kilometers from the National Wetland Inventory defined lake perimeter. As climate across the Prairie Pothole Region is highly variable, understanding historic patterns of surface-water expansion and contraction under drought-to-deluge conditions will be integral to predicting future effects of climate change on wetland function, loss and influence on other aquatic systems, including downstream waters. C1 [Vanderhoof, Melanie K.; Alexander, Laurie C.] US EPA, ORISE Co, Off Res & Dev, Natl Ctr Environm Assessment, 1200 Penn Ave NW,8623-P, Washington, DC 20460 USA. [Vanderhoof, Melanie K.] US Geol Survey, Geosci & Environm Change Sci Ctr, DFC, MS980,POB 25046, Lakewood, CO 80225 USA. RP Vanderhoof, MK (reprint author), US EPA, ORISE Co, Off Res & Dev, Natl Ctr Environm Assessment, 1200 Penn Ave NW,8623-P, Washington, DC 20460 USA.; Vanderhoof, MK (reprint author), US Geol Survey, Geosci & Environm Change Sci Ctr, DFC, MS980,POB 25046, Lakewood, CO 80225 USA. EM mvanderhoof@usgs.gov FU U.S. Department of Energy; EPA; U.S. EPA Office of Research and Development, National Center for Environmental Assessment FX This project was supported in part by an appointment to the Internship/Research Participation Program at the U.S. Environmental Protection Agency, Office of Research and Development, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and EPA. This work was also funded by the U.S. EPA Office of Research and Development, National Center for Environmental Assessment. We thank Megan Lang and Greg McCarty at USDA for their logistical support, and Scott Leibowitz, Ken Fritz, Jason Todd, and the anonymous reviewers for their valuable comments. The views expressed in this manuscript are solely those of the authors and do not necessarily reflect the views or policies of the U.S. EPA. NR 57 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0277-5212 EI 1943-6246 J9 WETLANDS JI Wetlands PD DEC PY 2016 VL 36 SU 2 BP S309 EP S321 DI 10.1007/s13157-015-0728-1 PG 13 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA EK7VU UT WOS:000394134100008 ER PT J AU Viard, F David, P Darling, JA AF Viard, Frederique David, Patrice Darling, John A. TI Marine invasions enter the genomic era: three lessons from the past, and the way forward SO CURRENT ZOOLOGY LA English DT Article DE biological invasions; cryptic species; cryptogenic species; eco-evolutionary processes; genomics; metabarcoding ID STANDING GENETIC-VARIATION; LOCAL ADAPTATION; MULTIPLE INTRODUCTIONS; EVOLUTIONARY RESPONSES; METABARCODING APPROACH; POPULATION GENOMICS; CREPIDULA-FORNICATA; ENVIRONMENTAL DNA; SPECIES INVASIONS; CRASSOSTREA-GIGAS AB The expanding scale and increasing rate of marine biological invasions have been documented since the early 20th century. Besides their global ecological and economic impacts, nonindigenous species (NIS) also have attracted much attention as opportunities to explore important eco-evolutionary processes such as rapid adaptation, long-distance dispersal and range expansion, and secondary contacts between divergent evolutionary lineages. In this context, genetic tools have been extensively used in the past 20 years. Three important issues appear to have emerged from such studies. First, the study of NIS has revealed unexpected cryptic diversity in what had previously been assumed homogeneous entities. Second, there has been surprisingly little evidence of strong founder events accompanying marine introductions, a pattern possibly driven by large propagule loads. Third, the evolutionary processes leading to successful invasion have been difficult to ascertain due to faint genetic signals. Here we explore the potential of novel tools associated with high-throughput sequencing (HTS) to address these still pressing issues. Dramatic increase in the number of loci accessible via HTS has the potential to radically increase the power of analyses aimed at species delineation, exploring the population genomic consequences of range expansions, and examining evolutionary processes such as admixture, introgression, and adaptation. Nevertheless, the value of this new wealth of genomic data will ultimately depend on the ability to couple it with expanded "traditional" efforts, including exhaustive sampling of marine populations over large geographic scales, integrated taxonomic analyses, and population level exploration of quantitative trait differentiation through common-garden and other laboratory experiments. C1 [Viard, Frederique] UPMC Univ Paris 06, Sorbonne Univ, CNRS,Stn Biol Roscoff,UMR 7144, Lab Adaptat & Diversite Milieu Marin,Team Div & C, F-29682 Roscoff, France. [David, Patrice] Univ Montpellier, CEFE UMR 5175, CNRS, UM EPHE 3, 1919 Route Mende, F-34293 Montpellier, France. [Darling, John A.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. RP Viard, F (reprint author), UPMC Univ Paris 06, Sorbonne Univ, CNRS,Stn Biol Roscoff,UMR 7144, Lab Adaptat & Diversite Milieu Marin,Team Div & C, F-29682 Roscoff, France. EM viard@sb-roscoff.fr FU Marine French Connection research group GDR CNRS [Ifremer 3445 MarCo]; ANR grant HYSEA [ANR-12-BSV7-0011]; United States Environmental Protection Agency, through its Office of Research and Development FX This article stems from the Doctoral Training Course "Genetique et Evolution des Organismes Marins" (Doctoral Programme SIBAGHE [University Montpellier II]) organized by Francois Bonhomme and Nicolas Bierne. P. D. and F. V. are thankful to them for their invitation to join this course. Meetings and workshops supported by the Marine French Connection research group GDR CNRS-Ifremer 3445 MarCo and by the ANR grant HYSEA (ANR-12-BSV7-0011) also stimulated discussions used in this review. The United States Environmental Protection Agency, through its Office of Research and Development, supported the research described here. Though it has been subjected to Agency administrative review and approved for publication, its content does not necessarily reflect official Agency policy. NR 102 TC 1 Z9 1 U1 12 U2 12 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1674-5507 EI 2396-9814 J9 CURR ZOOL JI Curr. Zool. PD DEC PY 2016 VL 62 IS 6 BP 629 EP 642 DI 10.1093/cz/zow053 PG 14 WC Zoology SC Zoology GA EL3GR UT WOS:000394508100010 ER PT J AU Vallero, DA AF Vallero, Daniel A. TI Air Pollution Monitoring Changes to Accompany the Transition from a Control to a Systems Focus SO SUSTAINABILITY LA English DT Review DE air pollution control technology; life cycle assessment (LCA); exposure potential; design for environment (DfE); design for disassembly (DfD); pollution prevention; systems engineering ID LIFE-CYCLE ASSESSMENT; HUMAN EXPOSURE; NEAR-FIELD; CHEMICALS; INDOOR; PESTICIDES; OZONE; TOOLS; HOUSE; DUST AB During the 20th century, air pollution control technologies grew at an amazingly rapid rate. Air quality in much of the industrialized world greatly improved as the efficiencies of these technologies improved. This continued improvement in pollution control has more recently been complemented with measures to prevent the emission of air pollutants. The previous, exclusive focus on treatment requires systems thinking. This review provides a framework for this Special Issue of Sustainability by describing the new tools that are needed to support this new, broader focus, including life cycle assessments, exposure models, and sustainable design. C1 [Vallero, Daniel A.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27709 USA. RP Vallero, DA (reprint author), US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27709 USA. EM vallero.daniel@epa.gov NR 33 TC 0 Z9 0 U1 2 U2 2 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 2071-1050 J9 SUSTAINABILITY-BASEL JI Sustainability PD DEC PY 2016 VL 8 IS 12 AR 1216 DI 10.3390/su8121216 PG 9 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Environmental Sciences; Environmental Studies SC Science & Technology - Other Topics; Environmental Sciences & Ecology GA EJ6FR UT WOS:000393315100002 ER PT J AU Messner, MJ Berger, P AF Messner, Michael J. Berger, Philip TI Response to: Comment on "Cryptosporidium Infection Risk: Results of New Dose-Response Modeling"-Discussion of Underlying Assumption and Their Implications SO RISK ANALYSIS LA English DT Letter C1 [Messner, Michael J.; Berger, Philip] US EPA, Off Ground Water & Drinking Water 4607M, 1200 Penn Ave NW, Washington, DC 20460 USA. RP Messner, MJ (reprint author), US EPA, Off Ground Water & Drinking Water 4607M, 1200 Penn Ave NW, Washington, DC 20460 USA. EM Messner.Michael@epa.gov NR 0 TC 0 Z9 0 U1 2 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0272-4332 EI 1539-6924 J9 RISK ANAL JI Risk Anal. PD DEC PY 2016 VL 36 IS 12 BP 2193 EP 2194 DI 10.1111/risa.12755 PG 2 WC Public, Environmental & Occupational Health; Mathematics, Interdisciplinary Applications; Social Sciences, Mathematical Methods SC Public, Environmental & Occupational Health; Mathematics; Mathematical Methods In Social Sciences GA EJ6OI UT WOS:000393338300002 PM 27996160 ER PT J AU Vallero, DA AF Vallero, Daniel A. TI Air Pollution Monitoring Changes to Accompany the Transition from a Control to a Systems Focus SO SUSTAINABILITY LA English DT Review DE air pollution control technology; life cycle assessment (LCA); exposure potential; design for environment (DfE); design for disassembly (DfD); pollution prevention; systems engineering ID LIFE-CYCLE ASSESSMENT; HUMAN EXPOSURE; NEAR-FIELD; CHEMICALS; INDOOR; PESTICIDES; OZONE; TOOLS; HOUSE; DUST AB During the 20th century, air pollution control technologies grew at an amazingly rapid rate. Air quality in much of the industrialized world greatly improved as the efficiencies of these technologies improved. This continued improvement in pollution control has more recently been complemented with measures to prevent the emission of air pollutants. The previous, exclusive focus on treatment requires systems thinking. This review provides a framework for this Special Issue of Sustainability by describing the new tools that are needed to support this new, broader focus, including life cycle assessments, exposure models, and sustainable design. C1 [Vallero, Daniel A.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27709 USA. RP Vallero, DA (reprint author), US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27709 USA. EM vallero.daniel@epa.gov NR 33 TC 0 Z9 0 U1 4 U2 4 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 2071-1050 J9 SUSTAINABILITY-BASEL JI Sustainability PD DEC PY 2016 VL 8 IS 12 AR 1216 DI 10.3390/su8121216 PG 9 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Environmental Sciences; Environmental Studies SC Science & Technology - Other Topics; Environmental Sciences & Ecology GA EE1CA UT WOS:000389317100007 ER PT J AU Hester, SD Bhat, V Chorley, BN Carswell, G Jones, W Wehmas, LC Wood, CE AF Hester, Susan D. Bhat, Virunya Chorley, Brian N. Carswell, Gleta Jones, Wendell Wehmas, Leah C. Wood, Charles E. TI Dose-Response Analysis of RNA-Seq Profiles in Archival Formalin-Fixed Paraffin-Embedded Samples SO TOXICOLOGICAL SCIENCES LA English DT Article DE RNA-sequencing; toxicogenomics; dose-response; FFPE; benchmark dose; archival resources ID GENE-EXPRESSION; KEY EVENTS; TRANSCRIPT QUANTIFICATION; DICHLOROACETIC ACID; RISK-ASSESSMENT; GENOMIC DATA; CONCORDANCE; TISSUES; QUALITY; MOUSE AB Use of archival resources has been limited to date by inconsistent methods for genomic profiling of degraded RNA from formalin-fixed paraffin-embedded (FFPE) samples. RNA-sequencing offers a promising way to address this problem. Here, we evaluated transcriptomic dose responses using RNA-sequencing in paired FFPE and frozen (FROZ) samples from 2 archival studies in mice, one <2 years old and the other >20 years old. Experimental treatments included 3 different doses of di(2-ethylhexyl) phthalate or dichloroacetic acid for the recently archived and older studies, respectively. Total RNA was ribo-depleted and sequenced using the Illumina HiSeq platform. In the recently archived study, FFPE samples had 35% lower total counts compared to FROZ samples but high concordance in fold-change values of differentially expressed genes (DEGs) (r(2) = 0.99), highly enriched pathways (90% overlap with FROZ), and benchmark dose estimates for preselected target genes (<5% difference vs FROZ). In contrast, older FFPE samples had markedly lower total counts (3% of FROZ) and poor concordance in global DEGs and pathways. However, counts from FFPE and FROZ samples still positively correlated (r(2) = 0.84 across all transcripts) and showed comparable dose responses for more highly expressed target genes. These findings highlight potential applications and issues in using RNA-sequencing data from FFPE samples. Recently archived FFPE samples were highly similar to FROZ samples in sequencing quality metrics, DEG profiles, and dose-response parameters, while further methods development is needed for older lower-quality FFPE samples. This work should help advance the use of archival resources in chemical safety and translational science. C1 [Hester, Susan D.; Chorley, Brian N.; Carswell, Gleta; Wehmas, Leah C.; Wood, Charles E.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC USA. [Bhat, Virunya] NSF Int, Ann Arbor, MI USA. [Jones, Wendell] Q2 Solut, Express Anal Genom Serv, Genom Bioinformat, Durham, NC USA. RP Wood, CE (reprint author), US EPA, MD-B105-03,109 TW Alexander Dr, Res Triangle Pk, NC 27709 USA. EM wood.charles@epa.gov FU U.S. EPA Office of Research and Development FX This work was supported by the U.S. EPA Office of Research and Development. NR 47 TC 1 Z9 1 U1 3 U2 3 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD DEC PY 2016 VL 154 IS 2 BP 202 EP 213 DI 10.1093/toxsci/kfw161 PG 12 WC Toxicology SC Toxicology GA EJ5VJ UT WOS:000393286500004 PM 27562560 ER PT J AU Heath, NK Pleim, JE Gilliam, RC Kang, DW AF Heath, Nicholas K. Pleim, Jonathan E. Gilliam, Robert C. Kang, Daiwen TI A simple lightning assimilation technique for improving retrospective WRF simulations SO Journal of Advances in Modeling Earth Systems LA English DT Article ID NONHYDROSTATIC ATMOSPHERIC MODEL; LAND-SURFACE MODEL; PART I; CONVECTIVE PARAMETERIZATION; PRECIPITATION FORECASTS; METEOROLOGICAL MODEL; CLIMATE; IMPACT; LAYER AB Convective rainfall is often a large source of error in retrospective modeling applications. In particular, positive rainfall biases commonly exist during summer months due to overactive convective parameterizations. In this study, lightning assimilation was applied in the Kain-Fritsch (KF) convective scheme to improve retrospective simulations using the Weather Research and Forecasting (WRF) model. The assimilation method has a straightforward approach: force KF deep convection where lightning is observed and, optionally, suppress deep convection where lightning is absent. WRF simulations were made with and without lightning assimilation over the continental United States for July 2012, July 2013, and January 2013. The simulations were evaluated against NCEP stage-IV precipitation data and MADIS near-surface meteorological observations. In general, the use of lightning assimilation considerably improves the simulation of summertime rainfall. For example, the July 2012 monthly averaged bias of 6 h accumulated rainfall is reduced from 0.54 to 0.07 mm and the spatial correlation is increased from 0.21 to 0.43 when lightning assimilation is used. Statistical measures of near-surface meteorological variables also are improved. Consistent improvements also are seen for the July 2013 case. These results suggest that this lightning assimilation technique has the potential to substantially improve simulation of warm-season rainfall in retrospective WRF applications. C1 [Heath, Nicholas K.; Pleim, Jonathan E.; Gilliam, Robert C.; Kang, Daiwen] US EPA, Computat Exposure Div, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. RP Heath, NK (reprint author), US EPA, Computat Exposure Div, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. EM Heath.Nicholas@epa.gov NR 37 TC 0 Z9 0 U1 3 U2 3 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 1942-2466 J9 J ADV MODEL EARTH SY JI J. Adv. Model. Earth Syst. PD DEC PY 2016 VL 8 IS 4 BP 1806 EP 1824 DI 10.1002/2016MS000735 PG 19 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA EI9FL UT WOS:000392813100016 ER PT J AU Wood, JP Calfee, MW Clayton, M Griffin-Gatchalian, N Touati, A Ryan, S Mickelsen, L Smith, L Rastogi, V AF Wood, J. P. Calfee, M. W. Clayton, M. Griffin-Gatchalian, N. Touati, A. Ryan, S. Mickelsen, L. Smith, L. Rastogi, V. TI A simple decontamination approach using hydrogen peroxide vapour for Bacillus anthracis spore inactivation SO JOURNAL OF APPLIED MICROBIOLOGY LA English DT Article DE antimicrobials; Bacillus anthracis; bacterial spores; biocides; hydrogen peroxide vapour; sterilization ID CLOSTRIDIUM-DIFFICILE SPORES; LABORATORY-SCALE; SURFACES; EFFICACY; CONTAMINATION; SUBTILIS; SYSTEM AB Aims: To evaluate the use of relatively low levels of hydrogen peroxide vapour (HPV) for the inactivation of Bacillus anthracis spores within an indoor environment. Methods and Results: Laboratory-scale decontamination tests were conducted using bacterial spores of both B. anthracis Ames and Bacillus atrophaeus inoculated onto several types of materials. Pilot-scale tests were also conducted using a larger chamber furnished as an indoor office. Commercial off-the-shelf (COTS) humidifiers filled with aqueous solutions of 3 or 8% hydrogen peroxide (H2O2) were used to generate the HPV inside the mock office. The spores were exposed to HPV for periods ranging from 8 h up to 1 week. Conclusions: Four-to seven-day exposures to low levels of HPV (average air concentrations of approx. 5-10 parts per million) were effective in inactivating B. anthracis spores on multiple materials. The HPV can be generated with COTS humidifiers and household H2O2 solutions. With the exception of one test/material, B. atrophaeus spores were equally or more resistant to HPV inactivation compared to those from B. anthracis Ames. Significance and Impact of the Study: This simple and effective decontamination method is another option that could be widely applied in the event of a B. anthracis spore release. C1 [Wood, J. P.; Calfee, M. W.; Ryan, S.] US EPA, Natl Homeland Secur Res Ctr, NC Mail Code E343-06, Res Triangle Pk, NC 27711 USA. [Clayton, M.; Griffin-Gatchalian, N.] ARCADIS Inc, Durham, NC USA. [Touati, A.] Jacobs Technol Inc, Res Triangle Pk, NC USA. [Mickelsen, L.] US EPA, Consequence Management Advisory Div, Res Triangle Pk, NC 27711 USA. [Smith, L.; Rastogi, V.] US Army, Edgewood Chem & Biol Ctr, Gunpowder, MD USA. RP Wood, JP (reprint author), US EPA, Natl Homeland Secur Res Ctr, NC Mail Code E343-06, Res Triangle Pk, NC 27711 USA. EM wood.joe@epa.gov FU US Environmental Protection Agency (EPA) through its Office of Research and Development [EP-C-09-027]; ARCADIS, Inc. FX The US Environmental Protection Agency (EPA) through its Office of Research and Development funded and directed the research described herein under contract EP-C-09-027 with ARCADIS, Inc. It has been subjected to the Agency's review and has been approved for publication. Note that approval does not signify that the contents necessarily reflect the views of the Agency. Mention of trade names, products or services does not convey official EPA approval, endorsement or recommendation. NR 27 TC 0 Z9 0 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1364-5072 EI 1365-2672 J9 J APPL MICROBIOL JI J. Appl. Microbiol. PD DEC PY 2016 VL 121 IS 6 BP 1603 EP 1615 DI 10.1111/jam.13284 PG 13 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA EI9PK UT WOS:000392840500011 PM 27569380 ER PT J AU Sowa, SP Herbert, M Mysorekar, S Annis, GM Hall, K Nejadhashemi, AP Woznicki, SA Wang, LZ Doran, PJ AF Sowa, Scott P. Herbert, Matthew Mysorekar, Sagar Annis, Gust M. Hall, Kimberly Nejadhashemi, A. Pouyan Woznicki, Sean A. Wang, Lizhu Doran, Patrick J. TI How much conservation is enough? Defining implementation goals for healthy fish communities in agricultural rivers SO JOURNAL OF GREAT LAKES RESEARCH LA English DT Article DE Streams; Index of biotic integrity; Water quality; Non-point source pollution; Agriculture; Cost-benefit analyses ID CONTERMINOUS UNITED-STATES; SOURCE POLLUTION MODELS; LAKE-ERIE BASIN; STREAM ECOSYSTEMS; BIOTIC INTEGRITY; LAND-USE; WATERSHED-SCALE; LANDSCAPE INFLUENCES; AQUATIC ECOSYSTEMS; MIDWESTERN RIVERS AB "How much conservation is enough?" is one of the most important and difficult questions to answer. In this work, we demonstrate an approach to specifically answer this question for conservation strategies designed to address nonpoint source pollution in agriculturally-dominated watersheds. We developed empirical models relating conservation investments and actions to measures of stream water quality and fish community health. Our results are consistent with other studies that demonstrate a need for extensive implementation of conservation practices in agricultural landscapes to see measurable improvements in ecological conditions. Our results also demonstrate the influence spatial grain can have on answering "how much conservation is enough?" Our coarse-grained analyses suggest that water quality in at the outlets of four watersheds could be improved to the point that water quality was no longer limiting the fish community with only about 18% of the agricultural lands treated with conservation practices and incentive payments totaling $7.7M. Yet, finer-grained subbasin analyses predict fish communities would still be limited in many tributaries of these watersheds even with 50% of lands treated and incentive payments totaling $44M. Consequently, coarsegrained analyses could significantly underestimate scope of the solution needed to address these impacts to stream ecosystems. Finding balanced solutions to address agricultural nonpoint source pollution throughout the Great Lalces will require unprecedented collaboration from local to regional scales. Herein, we provide examples of how this work is supporting collaborative efforts to establish realistic ecological goals and associated performance measures and strategic implementation of practices throughout the Saginaw Bay drainage. (C) 2016 International Association for Great Lakes Research. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license. C1 [Sowa, Scott P.; Herbert, Matthew; Mysorekar, Sagar; Annis, Gust M.; Hall, Kimberly; Doran, Patrick J.] Nature Conservancy, 101 East Grand River Ave, Lansing, MI 48906 USA. [Nejadhashemi, A. Pouyan; Woznicki, Sean A.] Michigan State Univ, Dept Biosyst & Agr Engn, Farrall Agr Engn Hall,524 S Shaw Lane, E Lansing, MI 48824 USA. [Wang, Lizhu] Int Joint Commiss, 100 Ouellette Ave,8th Floor, Windsor, ON N9A 6T3, Canada. [Woznicki, Sean A.] US EPA, Ecol & Human Community Anal Branch, Natl Exposure Res Lab, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. RP Sowa, SP (reprint author), Nature Conservancy, 101 East Grand River Ave, Lansing, MI 48906 USA. EM ssowa@tnc.org; mherbert@tnc.org; smysorekar@gmail.com; gannis@tnc.org; kimberly.hall@tnc.org; pouyan@msu.edu; woznicki.sean@epa.gov; wangl@windsor.ijc.org; pdoran@tnc.org FU Wildlife component of the USDA NRCS Conservation Effects Assessment Project [68-7482-9-512, 68-7482-11-501]; Charles Stewart Mott Foundation; Herbert H. and Grace A. Dow Foundation; Nature Conservancy's Great Lakes Fund for Partnership in Conservation Science and Economics FX We want to thank to Charlie Rewa for his unwavering support and administration of this project. We also want to thank our Advisory Panel members Charlie Bauer, Patti Copes, Abigail Ertel, Dawn Hergott, Jim Hergott, Melissa Higbee, Mike Kelly, Jim Kratz, Lisha Ramsdell, Jeanette Renn, Steve Shine, and Tom Wert. Their guidance an input to this project was invaluable. We also want to thank our key collaborators on this project that helped with compiling data and providing reviews and analyses, including; Jon Bartholic, Tia Bowe, Layla Cole, Arthur Cooper, Dana Infante, Phanikumar Mantha, Chaopeng Shen, Jana Stewart, George Wallace, Susan Wallace, and Brad Wardynski. Funding for this project was provided by the Wildlife component of the USDA NRCS Conservation Effects Assessment Project (Grant Agreements 68-7482-9-512 and 68-7482-11-501) and the Charles Stewart Mott Foundation. Additional financial support was provided by The Herbert H. and Grace A. Dow Foundation and The Nature Conservancy's Great Lakes Fund for Partnership in Conservation Science and Economics. NR 148 TC 5 Z9 5 U1 5 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0380-1330 J9 J GREAT LAKES RES JI J. Gt. Lakes Res. PD DEC PY 2016 VL 42 IS 6 BP 1302 EP 1321 DI 10.1016/j.jglr.2016.09.011 PG 20 WC Environmental Sciences; Limnology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA EI5VL UT WOS:000392564300016 ER PT J AU Mount, DR Erickson, RJ Highland, TL Hockett, JR Hoff, DJ Jenson, CT Norberg-King, TJ Peterson, KN Polaske, ZM Wisniewski, S AF Mount, David R. Erickson, Russell J. Highland, Terry L. Hockett, J. Russell Hoff, Dale J. Jenson, Correne T. Norberg-King, Teresa J. Peterson, Kira N. Polaske, Zachary M. Wisniewski, Stephanie TI THE ACUTE TOXICITY OF MAJOR ION SALTS TO CERIODAPHNIA DUBIA: I. INFLUENCE OF BACKGROUND WATER CHEMISTRY SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Aquatic toxicology; Major ions; Ceriodaphnia dubia; Toxicity mechanism; Dose-response modeling ID IRRIGATION DRAIN WATER; FRESH-WATER; AQUATIC TOXICITY; SODIUM-SULFATE; DAPHNIA-MAGNA; HARDNESS; CHLORIDE; CALCIUM; MODELS; FIELD AB The ions Na+, K+, Ca2+, Mg2+, Cl-, SO42-, and HCO3-/CO32- (referred to in the present study as "major ions") are present in all freshwaters and physiologically required by aquatic organisms but can increase to harmful levels from a variety of anthropogenic activities. It is also known that the toxicities of major ion salts can vary depending on the concentrations of other ions, and understanding these relationships is key to establishing appropriate environmental limits. The authors present a series of experiments with Ceriodaphnia dubia to evaluate the acute toxicity of 12 major ion salts and to determine how toxicity of these salts varies as a function of background water chemistry. All salts except CaSO4 and CaCO3 were acutely toxic below saturation, with the lowest median lethal concentrations found for K salts. All 10 salts that showed toxicity also showed some degree of reduced toxicity as the ionic content of the background water increased. Experiments that independently varied Ca:Mg ratio, Na:K ratio, Cl:SO4 ratio, and alkalinity/pH demonstrated that Ca concentration was the primary factor influencing the toxicities of Na and Mg salts, whereas the toxicities of K salts were primarily influenced by the concentration of Na. These experiments also indicated multiple mechanisms of toxicity and suggested important aspects of dosimetry; the toxicities of K, Mg, and Ca salts were best related to the chemical activity of the cation, whereas the toxicities of Na salts also reflected an influence of the anions and were well correlated with osmolarity. Understanding these relationships between major ion toxicity and background water chemistry should aid in the development of sensible risk-assessments and regulatory standards. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America. C1 [Mount, David R.; Erickson, Russell J.; Highland, Terry L.; Hockett, J. Russell; Hoff, Dale J.; Jenson, Correne T.; Norberg-King, Teresa J.; Peterson, Kira N.] US EPA, Duluth, MN 55804 USA. [Polaske, Zachary M.; Wisniewski, Stephanie] EMR, Duluth, MN USA. RP Erickson, RJ (reprint author), US EPA, Duluth, MN 55804 USA. EM erickson.russell@epa.gov FU USEPA Safe and Sustainable Water Resources Research Program FX T.D. Dawson supervised the culture of test organisms used in the present study and provided input to the experimental design and execution. We thank D.J. Soucek and J.R.F. Elphick for technical consultation and for providing additional details regarding their work. We also thank C.M. Wood for the suggestion to test the toxicities of mannitol and gluconate salts. Funding for this work was provided by the USEPA Safe and Sustainable Water Resources Research Program. NR 31 TC 0 Z9 0 U1 9 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD DEC PY 2016 VL 35 IS 12 BP 3039 EP 3057 DI 10.1002/etc.3487 PG 19 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA EG4RM UT WOS:000391031400017 PM 27167636 ER PT J AU Giri, C Long, J AF Giri, Chandra Long, Jordan TI Is the Geographic Range of Mangrove Forests in the Conterminous United States Really Expanding? SO SENSORS LA English DT Article DE geographic range expansion; mangrove forests; Landsat; climate change; mangrove change ID GULF-OF-MEXICO; SEA-LEVEL RISE; CLIMATE-CHANGE; LAND-COVER; NORTHERN GULF; SALT-MARSHES; FLORIDA; EXPANSION; MIGRATION; REGION AB Changes in the distribution and abundance of mangrove species within and outside of their historic geographic range can have profound consequences in the provision of ecosystem goods and services they provide. Mangroves in the conterminous United States (CONUS) are believed to be expanding poleward (north) due to decreases in the frequency and severity of extreme cold events, while sea level rise is a factor often implicated in the landward expansion of mangroves locally. We used similar to 35 years of satellite imagery and in situ observations for CONUS and report that: (i) poleward expansion of mangrove forest is inconclusive, and may have stalled for now, and (ii) landward expansion is actively occurring within the historical northernmost limit. We revealed that the northernmost latitudinal limit of mangrove forests along the east and west coasts of Florida, in addition to Louisiana and Texas has not systematically expanded toward the pole. Mangrove area, however, expanded by 4.3% from 1980 to 2015 within the historic northernmost boundary, with the highest percentage of change in Texas and southern Florida. Several confounding factors such as sea level rise, absence or presence of sub-freezing temperatures, land use change, impoundment/dredging, changing hydrology, fire, storm, sedimentation and erosion, and mangrove planting are responsible for the change. Besides, sea level rise, relatively milder winters and the absence of sub-freezing temperatures in recent decades may be enabling the expansion locally. The results highlight the complex set of forcings acting on the northerly extent of mangroves and emphasize the need for long-term monitoring as this system increases in importance as a means to adapt to rising oceans and mitigate the effects of increased atmospheric CO2. C1 [Giri, Chandra] US EPA, Sensing & Spatial Anal Branch, Off Res & Dev, 109 TW Alexander Dr, Durham, NC 27709 USA. [Long, Jordan] US Geol Survey, ARSC Res & Technol Solut, EROS Ctr, Sioux Falls, SD 57198 USA. RP Giri, C (reprint author), US EPA, Sensing & Spatial Anal Branch, Off Res & Dev, 109 TW Alexander Dr, Durham, NC 27709 USA. EM giri.chandra@epa.gov; jordan.long.ctr@usgs.gov NR 38 TC 0 Z9 0 U1 12 U2 12 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 1424-8220 J9 SENSORS-BASEL JI Sensors PD DEC PY 2016 VL 16 IS 12 AR 2010 DI 10.3390/s16122010 PG 17 WC Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation SC Chemistry; Electrochemistry; Instruments & Instrumentation GA EG8JM UT WOS:000391303000030 ER PT J AU Yu, TC Qiu, HY Yang, J Shao, Y Tao, L AF Yu, Tingchao Qiu, Hongying Yang, Jeffrey Shao, Yu Tao, Liang TI Mixing at double-Tee junctions with unequal pipe sizes in water distribution systems SO WATER SCIENCE AND TECHNOLOGY-WATER SUPPLY LA English DT Article DE double-Tee junctions; solute mixing; unequal pipe sizes; water distribution systems ID CROSS JUNCTIONS; JETS; FLOW AB Pipe flow mixing with various solute concentrations and flow rates at pipe junctions is investigated. The degree of mixing affects contaminant spread in a water distribution system, and many studies have focused on mixing at the cross junctions; however, only a few have focused on double-Tee junctions of unequal pipe diameters. To investigate the solute mixing at such junctions, a series of experiments was conducted in a turbulent regime (Re = 12,500-50,000) with different Reynolds number ratios and connecting pipe lengths. Dimensionless outlet concentrations were found to depend on mixing mechanism at the impinging interface of junctions, where junctions with a larger pipe diameter ratio were associated with more complete mixing. Further, the inlet Reynolds number ratio affected mixing more strongly than the outlet Reynolds number ratio. Finally, the dimensionless connecting pipe length in a double-Tee played an important and complicated role in the flow mixing. The results were used to develop two-dimensional isopleth maps for the calculation of normalized north outlet concentrations. C1 [Yu, Tingchao; Qiu, Hongying; Shao, Yu; Tao, Liang] Zhejiang Univ, Dept Civil Engn, Hangzhou 310058, Zhejiang, Peoples R China. [Yu, Tingchao; Qiu, Hongying; Shao, Yu; Tao, Liang] Key Lab Drinking Water Safety & Distribut Technol, Hangzhou 310058, Zhejiang, Peoples R China. [Yang, Jeffrey] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Shao, Y (reprint author), Zhejiang Univ, Dept Civil Engn, Hangzhou 310058, Zhejiang, Peoples R China.; Shao, Y (reprint author), Key Lab Drinking Water Safety & Distribut Technol, Hangzhou 310058, Zhejiang, Peoples R China. EM shaoyu1979@zju.edu.cn FU National Natural Science Foundation of China [51208457, 51478417]; Major Science and Technology Program for Water Pollution Control and Treatment in China [2012ZX07408-002, 2012ZX07403-004]; Fundamental Research Funds for the Central Universities FX The present research is funded by the National Natural Science Foundation of China (No. 51208457 and 51478417), the Major Science and Technology Program for Water Pollution Control and Treatment in China (2012ZX07408-002 and 2012ZX07403-004), and the Fundamental Research Funds for the Central Universities. US EPA has participated in the research and has approved the manuscript for external publication after administrative and peer review. Any opinions expressed in this paper are those of the authors and do not necessarily reflect the views of the Agency, therefore, no official endorsement should be inferred. NR 21 TC 0 Z9 0 U1 3 U2 3 PU IWA PUBLISHING PI LONDON PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND SN 1606-9749 J9 WATER SCI TECH-W SUP JI Water Sci. Technol.-Water Supply PD DEC PY 2016 VL 16 IS 6 BP 1595 EP 1602 DI 10.2166/ws.2016.076 PG 8 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA EG5XQ UT WOS:000391118500012 ER PT J AU Donohue, MJ Wymer, L AF Donohue, Maura J. Wymer, Larry TI Increasing Prevalence Rate of Nontuberculous Mycobacteria Infections in Five States, 2008-2013 SO ANNALS OF THE AMERICAN THORACIC SOCIETY LA English DT Article AB Rationale: Many nontuberculous mycobacteria (NTM) are clinically significant pathogens that cause disease in a variety of different human organs and tissues. Objectives: A population-based study was undertaken to investigate the prevalence of patients with a positive specimen for NTM within five states of the United States. Methods: We determined the case and age distribution of patients with at least one specimen positive for NTM, using data submitted to the disease surveillance systems of five states (Maryland, Mississippi, Missouri, Ohio, and Wisconsin) between 2008 and 2013. Crude, age-specific, and age-adjusted prevalence rates per 100,000 persons were calculated for each state. Measurements and Main Results: From 2008 to 2013, a total of 24,226 NTM cases were reported to the disease surveillance systems of the five states. The overall average annual age-adjusted prevalence rate rose from 8.7 to 13.9 per 100,000 persons between the beginning and end of the surveillance period. The number of cases and case rate in the 50-80+-year age group was higher than in the 0-49-year age group. Prevalence by age category differed among the five states. The highest number of NTM cases was observed in Mississippi for the 80+-year age group, whereas Wisconsin observed the highest number of NTM cases in the 60- to 69-year age group. Conclusions: From 2008 to 2013, the number of patients with positive specimens for NTM rose. This trend is likely to continue in the coming decade as the U.S. population ages. To reduce the prevalence of NTM infections, medical guidance for susceptible populations is needed regarding actions that can be taken to avoid sources and routes of exposure to NTMs if the disease burden is to be reduced. C1 [Donohue, Maura J.; Wymer, Larry] US EPA, Off Res & Dev, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. RP Donohue, MJ (reprint author), US EPA, 26 W Martin Luther King Dr,Mail Stop 587, Cincinnati, OH 45268 USA. EM Donohue.maura@epa.gov FU U.S. Environmental Protection Agency, through its Office of Research and Development FX The U.S. Environmental Protection Agency, through its Office of Research and Development, funded and managed the research described here. It has been subjected to agency's administrative review and approved for publication. The views expressed in this paper are those of the authors and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1546-3222 EI 2325-6621 J9 ANN AM THORAC SOC JI Ann. Am. Thoracic Society PD DEC PY 2016 VL 13 IS 12 BP 2143 EP 2150 DI 10.1513/AnnalsATS.201605-353OC PG 8 WC Respiratory System SC Respiratory System GA EF9OF UT WOS:000390658800010 PM 27681202 ER PT J AU Shrivastava, D Mishra, SC Gordon, CJ AF Shrivastava, Devashish Mishra, Subhash C. Gordon, Christopher J. TI Modeling bioheat transfer processes and thermoregulatory responses SO JOURNAL OF THERMAL BIOLOGY LA English DT Editorial Material C1 [Shrivastava, Devashish] US FDA, 10903 New Hampshire Ave, Silver Spring, MD 20993 USA. [Mishra, Subhash C.] Dept Mech Engn, Gauhati 781039, Guwahati, India. [Gordon, Christopher J.] US EPA, Res Triangle Pk, NC 27707 USA. RP Shrivastava, D (reprint author), US FDA, 10903 New Hampshire Ave, Silver Spring, MD 20993 USA. EM devashish.shrivastava@gmail.com; scm_iitg@yahoo.com; cjgordon.gordon1@gmail.com NR 0 TC 0 Z9 0 U1 3 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0306-4565 J9 J THERM BIOL JI J. Therm. Biol. PD DEC PY 2016 VL 62 SI SI BP 97 EP 97 DI 10.1016/j.jtherbio.2016.11.011 PN B PG 1 WC Biology; Zoology SC Life Sciences & Biomedicine - Other Topics; Zoology GA EG0KF UT WOS:000390721000001 PM 27888935 ER PT J AU Zhang, YQ Cooper, OR Gaudel, A Thompson, AM Nedelec, P Ogino, SY West, JJ AF Zhang, Yuqiang Cooper, Owen R. Gaudel, Audrey Thompson, Anne M. Nedelec, Philippe Ogino, Shin-Ya West, J. Jason TI Tropospheric ozone change from 1980 to 2010 dominated by equatorward redistribution of emissions SO NATURE GEOSCIENCE LA English DT Article ID GREENHOUSE-GAS EMISSIONS; EARTH SYSTEM MODEL; AIR-QUALITY; ATMOSPHERIC CHEMISTRY; TERM CHANGES; CLIMATOLOGY; AEROSOLS; NOX; CO; INCREASES AB Ozone is an important air pollutant at the surface(1), and the third most important anthropogenic greenhouse gas in the troposphere(2). Since 1980, anthropogenic emissions of ozone precursors-methane, non-methane volatile organic compounds, carbon monoxide and nitrogen oxides (NOx)have shifted from developed to developing regions. Emissions have thereby been redistributed equatorwards(3-6), where they are expected to have a stronger effect on the tropospheric ozone burden due to greater convection, reaction rates and NOx sensitivity(7-11). Here we use a global chemical transport model to simulate changes in tropospheric ozone concentrations from 1980 to 2010, and to separate the influences of changes in the spatial distribution of global anthropogenic emissions of short-lived pollutants, the magnitude of these emissions, and the global atmospheric methane concentration. We estimate that the increase in ozone burden due to the spatial distribution change slightly exceeds the combined influences of the increased emission magnitude and global methane. Emission increases in Southeast, East and South Asia may be most important for the ozone change, supported by an analysis of statistically significant increases in observed ozone above these regions. The spatial distribution of emissions dominates global tropospheric ozone, suggesting that the future ozone burden will be determined mainly by emissions from low latitudes. C1 [Zhang, Yuqiang; West, J. Jason] Univ North Carolina Chapel Hill, Environm Sci & Engn Dept, Chapel Hill, NC 27599 USA. [Cooper, Owen R.; Gaudel, Audrey] Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA. [Cooper, Owen R.; Gaudel, Audrey] NOAA, Chem Sci Div, Earth Syst Res Lab, Boulder, CO 80305 USA. [Thompson, Anne M.] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. [Nedelec, Philippe] Univ Paul Sabatier Toulouse III, CNRS, Lab Aerol, FR-31062 Toulouse, France. [Ogino, Shin-Ya] Japan Agcy Marine Earth Sci & Technol, Yokosuka, Kanagawa 2370061, Japan. [Zhang, Yuqiang] Environm Protect Agcy, Res Triangle Pk, NC 27709 USA. RP West, JJ (reprint author), Univ North Carolina Chapel Hill, Environm Sci & Engn Dept, Chapel Hill, NC 27599 USA. EM jjwest@email.unc.edu RI West, Jason/J-2322-2015; Thompson, Anne /C-3649-2014; Manager, CSD Publications/B-2789-2015 OI West, Jason/0000-0001-5652-4987; Thompson, Anne /0000-0002-7829-0920; FU National Institute of Environmental Health Sciences [1 R21 ES022600-01]; Environmental Protection Agency STAR [834285, RD83587801]; NOAA's Health of the Atmosphere and Atmospheric Chemistry and Climate Programs FX Y.Z. and J.J.W. were funded by National Institute of Environmental Health Sciences grant no. 1 R21 ES022600-01 and Environmental Protection Agency STAR grants no. 834285 and RD83587801, and O.R.C. and A.G. were funded by NOAA's Health of the Atmosphere and Atmospheric Chemistry and Climate Programs. The contents are solely the responsibility of the grantee and do not necessarily represent the official views of the US EPA or other funding sources. We thank the NCAR AMWG for developing and maintaining the diagnostic package for the model evaluation. We acknowledge the free use of O3 observation data from NOAA GMD for the remote sites of Barrow, Mauna Loa, Samoa and South Pole; Global Atmosphere Watch World Data Centre for Greenhouse Gases for Hohenpeissenberg, J. Schwab from University at Albany-SUNY for Whiteface Mountain, and P. Young of Lancaster University for processed ozonesonde climatology of ref. 25. NR 47 TC 1 Z9 1 U1 13 U2 13 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1752-0894 EI 1752-0908 J9 NAT GEOSCI JI Nat. Geosci. PD DEC PY 2016 VL 9 IS 12 BP 875 EP + DI 10.1038/NGEO2827 PG 7 WC Geosciences, Multidisciplinary SC Geology GA EF6ZA UT WOS:000390478700011 ER PT J AU Belair, DG Wolf, CJ Das, K Abbott, BD AF Belair, D. G. Wolf, C. J. Das, K. Abbott, B. D. TI Engineered Organotypic Human Culture Model To Examine Morphogenetic Fusion In Vitro SO TISSUE ENGINEERING PART A LA English DT Meeting Abstract CT TERMIS - Americas Conference and Exhibition CY DEC 11-14, 2016 CL San Diego, CA SP TERMIS C1 [Belair, D. G.; Wolf, C. J.; Das, K.; Abbott, B. D.] US EPA, ORD NHEERL TAD, Res Triangle Pk, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1937-3341 EI 1937-335X J9 TISSUE ENG PT A JI Tissue Eng. Part A PD DEC PY 2016 VL 22 SU 1 MA 235 BP S62 EP S62 PG 1 WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology SC Cell Biology; Biotechnology & Applied Microbiology GA EF8HF UT WOS:000390569200231 ER PT J AU Palanisamy, K Mezgebe, B Sorial, GA Sahle-Demessie, E AF Palanisamy, Keerthisaranya Mezgebe, Bineyam Sorial, George A. Sahle-Demessie, Endalkachew TI Biofiltration of Chloroform in a Trickle Bed Air Biofilter Under Acidic Conditions SO WATER AIR AND SOIL POLLUTION LA English DT Article DE Biofiltration; Chloroform; Filamentous fungi; Cometabolism; Ethanol; Trickle bed air biofilter ID MICROBIAL COMMUNITY STRUCTURE; N-HEXANE; BIOLOGICAL TREATMENT; WATER-TREATMENT; TREATMENT-PLANT; BUTYL ETHER; BY-PRODUCTS; REMOVAL; PERFORMANCE; METHANOL AB In this paper, the application of biofiltration is investigated for controlled removal of gas phase chloroform through cometabolic degradation with ethanol. A trickle bed air biofilter (TBAB) operated under acidic pH 4 is subjected to aerobic biodegradation of chloroform and ethanol. The TBAB is composed of pelleted diatomaceous earth filter media inoculated with filamentous fungi species, which served as the principle biodegrading microorganism. The removal efficiencies of 5 ppm(v) of chloroform mixed with different ratios of ethanol as cometabolite (25, 50, 100, 150, and 200 ppm(v)) ranged between 69.9 and 80.9%. The removal efficiency, reaction rate kinetics, and the elimination capacity increased proportionately with an increase in the cometabolite concentration. The carbon recovery from the TBAB amounted to 69.6% of the total carbon input. It is postulated that the remaining carbon contributed to excess biomass yield within the system. Biomass control strategies such as starvation and stagnation were employed at different phases of the experiment. The chloroform removal kinetics provided a maximum reaction rate constant of 0.0018 s(-1). The highest ratio of chemical oxygen demand (COD)(removal)/nitrogenutilization was observed at 14.5. This study provides significant evidence that the biodegradation of a highly chlorinated methane can be favored by cometabolism in a fungi-based TBAB. C1 [Palanisamy, Keerthisaranya; Mezgebe, Bineyam; Sorial, George A.] Univ Cincinnati, Dept Biomed Chem & Environm Engn, Environm Engn Program, Cincinnati, OH 45220 USA. [Sahle-Demessie, Endalkachew] US EPA, Off Res & Dev, NRMRL, Cincinnati, OH 45268 USA. RP Sorial, GA (reprint author), Univ Cincinnati, Dept Biomed Chem & Environm Engn, Environm Engn Program, Cincinnati, OH 45220 USA. EM george.sorial@uc.edu FU U.S. Environmental Protection Agency [EPA 83454201-1]; University of Cincinnati Grants Program FX The work conducted was partly supported by the grant obtained from the U.S. Environmental Protection Agency EPA 83454201-1 in collaboration with the University of Cincinnati Grants Program. NR 49 TC 0 Z9 0 U1 3 U2 3 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0049-6979 EI 1573-2932 J9 WATER AIR SOIL POLL JI Water Air Soil Pollut. PD DEC PY 2016 VL 227 IS 12 AR 478 DI 10.1007/s11270-016-3194-3 PG 13 WC Environmental Sciences; Meteorology & Atmospheric Sciences; Water Resources SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences; Water Resources GA EF9WJ UT WOS:000390681500054 ER PT J AU Breitner, S Schneider, A Devlin, RB Ward-Caviness, CK Diaz-Sanchez, D Neas, LM Cascio, WE Peters, A Hauser, ER Shah, SH Kraus, WE AF Breitner, Susanne Schneider, Alexandra Devlin, Robert B. Ward-Caviness, Cavin K. Diaz-Sanchez, David Neas, Lucas M. Cascio, Wayne E. Peters, Annette Hauser, Elizabeth R. Shah, Svati H. Kraus, William E. TI Associations among plasma metabolite levels and short-term exposure to PM2.5 and ozone in a cardiac catheterization cohort SO ENVIRONMENT INTERNATIONAL LA English DT Review DE Particulate matter; Ozone; Metabolomics; Cardiovascular disease ID CORONARY-ARTERY-DISEASE; AIR-POLLUTION; CARDIOVASCULAR-DISEASE; PARTICULATE MATTER; INSULIN-RESISTANCE; ARGININE BIOAVAILABILITY; MYOCARDIAL-INFARCTION; MARKERS; RISK; METABOLOMICS AB Rationale: Exposure to ambient particulate matter (PM) and ozone has been associated with cardiovascular disease (CVD). However, the mechanisms linking PM and ozone exposure to CVD remain poorly understood. Objective: This study explored associations between short-term exposures to PM with a diameter <2.5 mu m (PM2.5) and ozone with plasma metabolite concentrations. Methods and results: We used cross-sectional data from a cardiac catheterization cohort at Duke University, North Carolina (NC), USA, accumulated between 2001 and 2007. Amino acids, acylcarnitines, ketones and total non-esterified fatty acid plasma concentrations were determined in fasting samples. Daily concentrations of PM2.5 and ozone were obtained from a Bayesian space-time hierarchical model, matched to each patient's residential address. Ten metabolites were selected for the analysis based on quality criteria and cluster analysis. Associations between metabolites and PM2.5 or ozone were analyzed using linear regression models adjusting for long-term trend and seasonality,calendar effects, meteorological parameters, and participant characteristics. We found delayed associations between PM2.5 or ozone and changes in metabolite levels of the glycine-ornithine- arginine metabolic axis and incomplete fatty acid oxidation associated with mitochondrial dysfunction. The strongest association was seen for an increase of 8.1 mu g/m(3) in PM2.5 with a lag of one day and decreased mean glycine concentrations (-2.5% [95% confidence interval: -3.8%; -1.2%]). Conclusions: Short-term exposures to ambient PM2.5 and ozone is associated with changes in plasma concentrations of metabolites in a cohort of cardiac catheterization patients. Our findings might help to understand the link between air pollution and cardiovascular disease. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Breitner, Susanne; Schneider, Alexandra; Ward-Caviness, Cavin K.; Peters, Annette] Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany. [Devlin, Robert B.; Diaz-Sanchez, David; Neas, Lucas M.; Cascio, Wayne E.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Ward-Caviness, Cavin K.; Hauser, Elizabeth R.; Shah, Svati H.; Kraus, William E.] Duke Univ, Sch Med, Durham, NC USA. RP Breitner, S (reprint author), German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Munchen, Inst Epidemiol 2, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany. EM susanne.breitner@helmholtz-muenchen.de OI Breitner, Susanne/0000-0002-0956-6911; Peters, Annette/0000-0001-6645-0985 FU United States Environmental Protection Agency (EPA) [R-82811201]; Health Effects Institute [4946-RFPA10-3/14-7] FX Research described in this article was conducted under contract to the Health Effects Institute (HEI), and organization jointly funded by the United States Environmental Protection Agency (EPA) (Assistance Award No. R-82811201), and certain motor vehicle and engine manufacturers. The contents of this article do not necessarily reflect the views of HEI, or its sponsors, nor do they necessarily reflect the view and policies of the EPA or motor vehicle and engine manufacturers.; This work was partially supported by Health Effects Institute 4946-RFPA10-3/14-7 to WEK. NR 56 TC 0 Z9 0 U1 11 U2 11 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0160-4120 EI 1873-6750 J9 ENVIRON INT JI Environ. Int. PD DEC PY 2016 VL 97 BP 76 EP 84 DI 10.1016/j.envint.2016.10.012 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA EE8YP UT WOS:000389912900009 PM 27792908 ER PT J AU Firestone, M Berger, M Foos, B Etzel, R AF Firestone, Michael Berger, Martha Foos, Brenda Etzel, Ruth TI Two Decades of Enhancing Children's Environmental Health Protection at the US Environmental Protection Agency SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article ID CHILDHOOD; EXPOSURE; HISTORY; RISKS AB This article provides an overview of public health efforts by the U.S. Environmental Protection Agency (EPA) during the past two decades to protect children's health from environmental hazards. It highlights examples of concrete steps and accomplishments toward improving environmental protection and health outcomes achieved through public policy, rules and regulations, increased scientific understanding, and public health messaging. Additionally, examples of future challenges for better understanding and improving children's environmental health are discussed. C1 [Firestone, Michael; Berger, Martha; Foos, Brenda; Etzel, Ruth] US EPA, Off Childrens Hlth Protect, Washington, DC 20460 USA. RP Firestone, M (reprint author), 1200 Penn Ave NW, Washington, DC 20460 USA. EM Firestone.Michael@EPA.gov NR 49 TC 0 Z9 0 U1 5 U2 5 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD DEC PY 2016 VL 124 IS 12 BP A214 EP A218 DI 10.1289/EHP1040 PG 5 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA EF3FX UT WOS:000390211200002 PM 27905272 ER PT J AU Glawe, D Wooten, M Lye, D AF Glawe, Diana Wooten, Marilyn Lye, Dennis TI Quality of Condensate From Air-Handling Units SO ASHRAE JOURNAL LA English DT Article ID COLLECTION AB Collecting condensate from large air-handling units (AHU) for on-site use is compelling, particularly in humid climates prone to drought. Identifying the optimal on-site use for the condensate requires knowledge of the quantity and quality of the condensate versus the quantity and quality required for potential on-site applications. This article provides evidence that condensate from properly maintained large AHUs is high-quality water, explains how system design and maintenance affect condensate quality, and highlights considerations for on-site applications of condensate. C1 [Glawe, Diana] Trinity Univ, Dept Engn Sci, San Antonio, TX 78212 USA. [Wooten, Marilyn] Trinity Univ, Dept Chem, San Antonio, TX 78212 USA. [Lye, Dennis] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. RP Glawe, D (reprint author), Trinity Univ, Dept Engn Sci, San Antonio, TX 78212 USA. NR 16 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC HEATING REFRIGERATING AIR-CONDITIONING ENG, INC, PI ATLANTA PA 1791 TULLIE CIRCLE NE, ATLANTA, GA 30329 USA SN 0001-2491 EI 1943-6637 J9 ASHRAE J JI ASHRAE J. PD DEC PY 2016 VL 58 IS 12 BP 14 EP + PG 8 WC Thermodynamics; Construction & Building Technology; Engineering, Mechanical SC Thermodynamics; Construction & Building Technology; Engineering GA EE6QG UT WOS:000389736700013 ER PT J AU Sun, M Arevalo, E Strynar, M Lindstrom, A Richardson, M Kearns, B Pickett, A Smith, C Knappe, DRU AF Sun, Mei Arevalo, Elisa Strynar, Mark Lindstrom, Andrew Richardson, Michael Kearns, Ben Pickett, Adam Smith, Chris Knappe, Detlef R. U. TI Legacy and Emerging Perfluoroalkyl Substances Are Important Drinking Water Contaminants in the Cape Fear River Watershed of North Carolina SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS LA English DT Article ID COMBUSTION ION CHROMATOGRAPHY; POLYFLUOROALKYL SUBSTANCES; CARBOXYLIC-ACIDS; PHYSICOCHEMICAL PROPERTIES; FLUORINATED ALTERNATIVES; ACTIVATED CARBON; CHAIN; PFASS; PRECURSORS; REMOVAL AB Long-chain per- and polyfluoroalkyl substances (PFASs) are being replaced by short-chain PFASs and fluorinated alternatives. For ten legacy PFASs and seven recently discovered perfluoroalkyl ether carboxylic acids (PFECAs), we report (1) their occurrence in the Cape Fear River (CFR) watershed, (2) their fate in water treatment processes, and (3) their adsorbability on powdered activated carbon (PAC). In the headwater region of the CFR basin, PFECAs were not detected in raw water of a drinking water treatment plant (DWTP), but concentrations of legacy PFASs were high. The U.S. Environmental Protection Agency's lifetime health advisory level (70 ng/L) for perfluorooctanesulfonic acid and perfluorooctanoic acid (PFOA) was exceeded on 57 of 127 sampling days. In raw water of a DWTP downstream of a PFAS manufacturer, the mean concentration of perfluoro-2-propoxypropanoic acid (PFPrOPrA), a replacement for PFOA, was 631 ng/L (n = 37). Six other PFECAs were detected, with three exhibiting chromatographic peak areas up to 15 times that of PFPrOPrA. At this DWTP, PFECA removal by coagulation, ozonation, biofiltration, and disinfection was negligible. The adsorbability of PFASs on PAC increased with increasing chain length. Replacing one CF2 group with an ether oxygen decreased the affinity of PFASs for PAC, while replacing additional CF2 groups did not lead to further affinity changes. C1 [Sun, Mei] Univ North Carolina Charlotte, Dept Civil & Environm Engn, Charlotte, NC 28223 USA. [Sun, Mei; Arevalo, Elisa; Knappe, Detlef R. U.] North Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA. [Strynar, Mark; Lindstrom, Andrew] US Environm Protect Agcy Res, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Richardson, Michael; Kearns, Ben] Cape Fear Publ Util Author, Wilmington, NC 28403 USA. [Pickett, Adam] Town Pittsboro, Pittsboro, NC 27312 USA. [Smith, Chris] Fayetteville Publ Works Commiss, Fayetteville, NC 28301 USA. RP Sun, M (reprint author), Univ North Carolina Charlotte, Dept Civil & Environm Engn, Charlotte, NC 28223 USA.; Sun, M (reprint author), North Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA. EM msun8@uncc.edu FU National Science Foundation [1550222]; Water Research Foundation [4344]; North Carolina Urban Water Consortium FX This research was supported by the National Science Foundation (Grant 1550222), the Water Research Foundation (Project 4344), and the North Carolina Urban Water Consortium. NR 30 TC 1 Z9 1 U1 26 U2 26 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2328-8930 J9 ENVIRON SCI TECH LET JI Environ. Sci. Technol. Lett. PD DEC PY 2016 VL 3 IS 12 BP 415 EP 419 DI 10.1021/acs.estlett.6b00398 PG 5 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA EE8JJ UT WOS:000389871200002 ER PT J AU Patlewicz, G Casati, S Basketter, DA Asturiol, D Roberts, DW Lepoittevin, JP Worth, AP Aschberger, K AF Patlewicz, Grace Casati, Silvia Basketter, David A. Asturiol, David Roberts, David W. Lepoittevin, Jean-Pierre Worth, Andrew P. Aschberger, Karin TI Can currently available non-animal methods detect pre and pro-haptens relevant for skin sensitization? SO REGULATORY TOXICOLOGY AND PHARMACOLOGY LA English DT Article DE Adverse Outcome Pathway; Skin sensitization; Pre-hapten; Pro-hapten; DPRA; h-CLAT; KeratinoSens (TM); Reaction mechanistic domain ID APPLICABILITY DOMAIN CLASSIFICATION; SCREENING CONTACT ALLERGENS; ADVERSE OUTCOME PATHWAYS; LYMPH-NODE ASSAY; IN-VITRO; PEPTIDE REACTIVITY; AIR EXPOSURE; TIMES-SS; ACTIVATION; METABOLISM AB Predictive testing to characterize substances for their skin sensitization potential has historically been based on animal tests such as the Local Lymph Node Assay (LLNA). In recent years, regulations in the cosmetics and chemicals sectors have provided strong impetus to develop non-animal alternatives. Three test methods have undergone OECD validation: the direct peptide reactivity assay (DPRA), the KeratinoSens (TM) and the human Cell Line Activation Test (h-CLAT). Whilst these methods perform relatively well in predicting LLNA results, a concern raised is their ability to predict chemicals that need activation to be sensitizing (pre- or pro-haptens). This current study reviewed an EURL ECVAM dataset of 127 substances for which information was available in the LLNA and three non-animal test methods. Twenty eight of the sensitizers needed to be activated, with the majority being pre-haptens. These were correctly identified by 1 or more of the test methods. Six substances were categorized exclusively as pro-haptens, but were correctly identified by at least one of the cell-based assays. The analysis here showed that skin metabolism was not likely to be a major consideration for assessing sensitization potential and that sensitizers requiring activation could be identified correctly using one or more of the current non-animal methods. Published by Elsevier Inc. C1 [Patlewicz, Grace] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA. [Casati, Silvia; Asturiol, David; Worth, Andrew P.; Aschberger, Karin] European Commiss, Joint Res Ctr, Directorate Hlth Consumers & Reference Mat F, Chem Safety & Alternat Methods Unit, Ispra, VA, Italy. [Basketter, David A.] DABMEB Consultancy Ltd, Sharnbrook, Beds, England. [Roberts, David W.] Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Liverpool, Merseyside, England. [Lepoittevin, Jean-Pierre] CNRS UMR 7177, Inst Chem, Strasbourg, France. [Lepoittevin, Jean-Pierre] Univ Strasbourg, Strasbourg, France. RP Patlewicz, G (reprint author), US EPA, Off Res & Dev, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27709 USA. EM patlewicz.grace@epa.gov NR 44 TC 0 Z9 0 U1 9 U2 9 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0273-2300 EI 1096-0295 J9 REGUL TOXICOL PHARM JI Regul. Toxicol. Pharmacol. PD DEC PY 2016 VL 82 BP 147 EP 155 DI 10.1016/j.yrtph.2016.08.007 PG 9 WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology SC Legal Medicine; Pharmacology & Pharmacy; Toxicology GA EE6PU UT WOS:000389735500014 PM 27569201 ER PT J AU Ferguson, KK Cantonwine, DE McElrath, TF Mukherjee, B Meeker, JD AF Ferguson, Kelly K. Cantonwine, David E. McElrath, Thomas F. Mukherjee, Bhramar Meeker, John D. TI Repeated measures analysis of associations between urinary bisphenol-A concentrations and biomarkers of inflammation and oxidative stress in pregnancy SO REPRODUCTIVE TOXICOLOGY LA English DT Article DE BPA; Oxidative stress; Inflammation; IL-6; Pregnancy; Biomarkers; Longitudinal ID C-REACTIVE PROTEIN; PHTHALATE METABOLITE; PRETERM BIRTH; HUMAN EXPOSURE; RISK; MARKERS; GROWTH; WOMEN; VARIABILITY; GENERATION AB Bisphenol-A (BPA) exposure occurs commonly and may adversely impact pregnancy. Endocrine disruption is posited as the primary mechanism of action, but oxidative stress and inflammation pathways may also be important. We investigated associations between BPA exposure and oxidative stress and inflammation in 482 pregnant women. Participants were recruited early in pregnancy and provided urine and plasma at up to four visits. We measured total BPA and two biomarkers of oxidative stress (8-hydroxydeoxyguanosine and 8-isoprostane) in urine from each visit. Inflammation markers, including C-reactive protein and four cytokines were measured in plasma from the same time points. In adjusted models, an interquartile range increase in BPA was associated with significant increases in both oxidative stress biomarkers (5-9% increase). Additionally, we observed significantly higher IL-6 concentrations in association with an interquartile range increase in BPA (8.95% increase). These systemic changes consequent to BPA exposure may mediate adverse birth outcomes and/or fetal development. (C) 2016 Elsevier Inc. All rights reserved. C1 [Ferguson, Kelly K.] Natl Inst Environm Hlth Sci, Epidemiol Branch, 111 TW Alexander Dr, Res Triangle Pk, NC USA. [Ferguson, Kelly K.; Meeker, John D.] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, 1415 Washington Hts, Ann Arbor, MI 48109 USA. [Cantonwine, David E.; McElrath, Thomas F.] Harvard Med Sch, Brigham & Womens Hosp, Dept Obstet & Gynecol, Div Maternal Fetal Med, 75 Francis St, Boston, MA USA. [Mukherjee, Bhramar] Univ Michigan, Sch Publ Hlth, Dept Biostat, 1415 Washington Hts, Ann Arbor, MI 48109 USA. RP Meeker, JD (reprint author), Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, 1415 Washington Hts, Ann Arbor, MI 48109 USA. EM meekerj@umich.edu OI Ferguson, Kelly/0000-0001-8467-3250 FU National Institute of Environmental Health Sciences, National Institutes of Health [R01ES018872, P42ES017198, P30ES017885] FX Funding was provided by the National Institute of Environmental Health Sciences, National Institutes of Health, grant numbers: R01ES018872, P42ES017198, and P30ES017885. NR 40 TC 0 Z9 0 U1 4 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0890-6238 J9 REPROD TOXICOL JI Reprod. Toxicol. PD DEC PY 2016 VL 66 BP 93 EP 98 DI 10.1016/j.reprotox.2016.10.002 PG 6 WC Reproductive Biology; Toxicology SC Reproductive Biology; Toxicology GA EE5XS UT WOS:000389683500010 PM 27751756 ER PT J AU Masih, A Lall, AS Taneja, A Singhvi, R AF Masih, Amit Lall, Anurag S. Taneja, Ajay Singhvi, Raj TI Inhalation exposure and related health risks of BTEX in ambient air at different microenvironments of a terai zone in north India SO ATMOSPHERIC ENVIRONMENT LA English DT Article DE BTEX; Inhalation exposure; Health risk; Terai zone; Microenvironments ID VOLATILE ORGANIC-COMPOUNDS; AROMATIC-HYDROCARBONS; COMPOUNDS VOCS; HONG-KONG; URBAN; POLLUTANTS; BENZENE; TOLUENE; AREA; ATMOSPHERE AB BTEX are recognized for their contribution as toxic and carcinogenic human health effects, and enhancement of the global greenhouse effect. Thus, an investigation of ambient BTEX was conducted at selected locations in Gorakhpur for a span of one year in order to ascertain the contagion levels. The concentrations of BTEX were measured at four locations in the city of Gorakhpur, which covers residential, agricultural, roadside and industrial areas with the help of low volume sampler. The samples were extracted with carbon disulphide by occasional agitation and the aromatic fraction was subjected to GC-FID. The average concentration of total BTEX in all samples was 50.8 mu g/m(3) and the total range was from 10.9 mu g/m(3) to 208.1 mu g/m(3) with the median of 44.8 mu g/m(3). The BTEX concentrations were found to be 27.8, 35.9, 65.6 and 68.6 mu g/m(3) at residential, agricultural, roadside and industrial sites respectively. The maximum concentration of total BTEX was found to be 61.9 mu g/m(3) in winter season, followed by 47.9 mu g/m(3) in summer and 42.7 mu g/m(3) in monsoon season. The industrial site (35%) had the highest BTEX contribution followed by roadside (33%), agricultural (18%) and residential site (14%). The concentration of BTEX decreased in the order toluene > benzene > ethylbenzene > xylene. The integrated lifetime cancer risk for benzene at all sites, and ethylbenzene at roadside area was found to be higher than the acceptable value and ranges between 1.0E-05 and 7.6E-06, although the non-cancer health risk was found to be within acceptable limit along all the sites. Risk assessment can be used as a tool to ascertain influence on public health and also to encourage risk preclusion approaches directed towards effectual reduction of adverse health effects. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Masih, Amit; Lall, Anurag S.] St Andrews Coll, Dept Chem, Environm Res Lab, Gorakhpur, Uttar Pradesh, India. [Taneja, Ajay] Dr Bhim Rao Ambedkar Univ, Dept Chem, Agra, Uttar Pradesh, India. [Singhvi, Raj] US EPA, Environm Response Team, Edison, NJ USA. RP Masih, A (reprint author), St Andrews Coll, Dept Chem, Environm Res Lab, Gorakhpur, Uttar Pradesh, India. EM amitmasih10@yahoo.com FU Department of Science and Technology (DST), New Delhi, India [SR/FTP/ES-77/2013] FX Financial support from Department of Science and Technology (DST), New Delhi, India in Project No. SR/FTP/ES-77/2013 is duly acknowledged. Authors gratefully acknowledge Revd. Prof. J. K. Lal (Principal) and Dr. S. D. Sharma (Head) Chemistry Department, St Andrew's College, Goraldipur, UP, India, for providing necessary facilities. Also thankful to Mr. Jay Patel, ERT, USEPA for providing technical support during the analysis of samples. NR 99 TC 0 Z9 0 U1 11 U2 11 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 EI 1873-2844 J9 ATMOS ENVIRON JI Atmos. Environ. PD DEC PY 2016 VL 147 BP 55 EP 66 DI 10.1016/j.atmosenv.2016.09.067 PG 12 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA ED0PE UT WOS:000388543600006 ER PT J AU Woody, MC Wong, HW West, J Arunachalam, S AF Woody, M. C. Wong, H. -W. West, J. J. Arunachalam, S. TI Multiscale predictions of aviation-attributable PM2.5 for US airports modeled using CMAQ with plume-in-grid and an aircraft-specific 1-D emission model SO ATMOSPHERIC ENVIRONMENT LA English DT Article DE CMAQ; Aircraft; Plume-in-grid; PM2.5 ID AIR-QUALITY; ORGANIC AEROSOL; PARTICULATE-MATTER; UNITED-STATES; PUBLIC-HEALTH; EXHAUST; IMPACTS; SCALE; PHOTOCHEMISTRY; VOLATILITY AB Aviation activities represent an important and unique mode of transportation, but also impact air quality. In this study, we aim to quantify the impact of aircraft on air quality, focusing on aviation-attributable PM2.5 at scales ranging from local (a few kilometers) to continental (spanning hundreds of kilometers) using the Community Multiscale Air Quality-Advanced Plume Treatment (CMAQ-APT) model. In our CMAQ-APT simulations, a plume scale treatment is applied to aircraft emissions from 99 major U.S. airports over the contiguous U.S. in January and July 2005. In addition to the plume scale treatment, we account for the formation of non-traditional secondary organic aerosols (NTSOA) from the oxidation of semivolatile and intermediate volatility organic compounds (S/IVOCs) emitted from aircraft, and utilize alternative emission estimates from the Aerosol Dynamics Simulation Code (ADSC). ADSC is a 1-D plume scale model that estimates engine specific PM and S/IVOC emissions at ambient conditions, accounting for relative humidity and temperature. We estimated monthly and contiguous U.S. average aviation attributable PM2.5 to be 2.7 ng m(-3) in January and 2.6 ng m(-3) in July using CMAQ-APT with ADSC emissions. This represents an increase of 40% and 12% in January and July, respectively, over impacts using traditional modeling approaches (traditional emissions without APT). The maximum fine scale (subgrid scale) hourly impacts at a major airport were 133.6 mu g m(-3) in January and 165.4 mu g m(-3) in July, considerably higher than the maximum grid-based impacts at the airport of 43 mu g m(-3) in January and 0.5 mu g m(-3) in July. Published by Elsevier Ltd. C1 [Woody, M. C.; Arunachalam, S.] Univ North Carolina Chapel Hill, Inst Environm, Chapel Hill, NC USA. [Woody, M. C.; West, J. J.] Univ North Carolina Chapel Hill, Dept Environm Sci & Engn, Chapel Hill, NC USA. [Woody, M. C.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Wong, H. -W.] Aerodyne Res Inc, Billerica, MA USA. [Wong, H. -W.] Univ Massachusetts, Dept Chem Engn, Lowell, MA USA. RP Woody, MC (reprint author), US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA. EM woody.matthew@epa.gov RI West, Jason/J-2322-2015 OI West, Jason/0000-0001-5652-4987 FU Federal Aviation Administration through grants under the Partnership for AiR Transportation Noise Emissions Reduction (PARTNER); Center for Excellence for Alternative Jet Fuels and Environment (ASCENT) FX This work was funded in part by the Federal Aviation Administration through grants under the Partnership for AiR Transportation Noise Emissions Reduction (PARTNER) (http://partner.mit.edu) and Center for Excellence for Alternative Jet Fuels and Environment (ASCENT) (https://ascent.aero/). We would like to thank Prakash Karamchandani of Ramboll ENVIRON, Inc. for providing the code and support for a prerelease version of CMAQv5.0.1 with APT, Mohammad Omary of the UNC Institute for the Environment for generating non-aviation emission model inputs, and Jared Bowden and Kevin Talgo of the UNC Institute for the Environment for generating meteorological model inputs. The aviation emissions inventories used for this work were provided by US DOT Volpe Center and are based on data provided by the US Federal Aviation Administration and EUROCONTROL in support of the objectives of the International Civil Aviation Organization Committee on Aviation Environmental Projection CO2 Task Group. Any opinions, finding, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the US DOT, Volpe Center, the US FAA, EUROCONTROL, or ICAO. NR 56 TC 0 Z9 0 U1 14 U2 14 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 EI 1873-2844 J9 ATMOS ENVIRON JI Atmos. Environ. PD DEC PY 2016 VL 147 BP 384 EP 394 DI 10.1016/j.atmosenv.2016.10.016 PG 11 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA ED0PE UT WOS:000388543600034 ER PT J AU Lin, N Chen, YC Du, W Shen, GF Zhu, X Huang, TB Wang, XL Cheng, HF Liu, JF Xue, CY Liu, GQ Zeng, EY Xing, BS Tao, S AF Lin, Nan Chen, Yuanchen Du, Wei Shen, Guofeng Zhu, Xi Huang, Tianbo Wang, Xilong Cheng, Hefa Liu, Junfeng Xue, Chunyu Liu, Guangqing Zeng, Eddy Y. Xing, Baoshan Tao, Shu TI Inhalation exposure and risk of polycyclic aromatic hydrocarbons (PAHs) among the rural population adopting wood gasifier stoves compared to different fuel-stove users SO ATMOSPHERIC ENVIRONMENT LA English DT Article DE Solid fuel combustion; PAHs; Inhalation exposure; Incremental lifetime cancer risk; Biomass gasifier stoves ID HOUSEHOLD AIR-POLLUTION; EQUIVALENCY FACTORS; IMPROVED COOKSTOVES; PARTICULATE MATTER; ENERGY EFFICIENCY; CANCER RISK; CHINA; EMISSIONS; HEALTH; COMBUSTION AB Polycyclic aromatica hydrocarbons (PAHs) are a group of compounds with carcinogenic potentials and residential solid fuel combustion is one major source of PAHs in most developing countries. Replacement of traditional stoves with improved ones is believed to be a practical approach to reduce pollutant emissions, however, field assessments on the performance and consequent impacts on air quality and human health after adopting improved stoves are rare. The study is the first time to quantify inhalation exposure to PAHs among the residents who adopted wood gasifier stoves. The results were compared to those still burning coals in the region and compared to exposure levels for different fuel/stove users in literature. The results showed that the PAHs exposure levels for the wood gasifier stove users were significantly lower than the values for those using traditional wood stoves reported in literature, and the daily exposure concentrations of BaPeq (Benzo[a]pyrene equivalent concentration) can be reduced by 48% -91% if traditional wood stoves were replaced by wood gasifier stoves. The corresponding Incremental Lifetime Cancer Risk (ILCR) decreased approximately four times from 1.94 x 10(-4) to 5.17 x 10(-5). The average concentration of the total 26 PAHs for the wood users was 1091 +/- 722 ng/m(3), which was comparable to 1060 +/- 927 ng/m(3) for those using anthracite coals, but the composition profiles were considerably different. The average BaPeq were 116 and 25.8 ng/m(3) for the wood and coal users, respectively, and the corresponding ILCR of the anthracite coal users was 1.69 x 10(-5), which was nearly one third of those using the wood gasifier stoves. The wood users exposed to not only high levels of high molecular weight PAHs, but relatively high fractions of particulate phase PAHs in small particles compared to the coal users, resulting in high exposure risks. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Lin, Nan; Chen, Yuanchen; Du, Wei; Shen, Guofeng; Zhu, Xi; Huang, Tianbo; Wang, Xilong; Cheng, Hefa; Liu, Junfeng; Tao, Shu] Peking Univ, Coll Urban & Environm Sci, Lab Earth Surface Proc, Beijing 100871, Peoples R China. [Xue, Chunyu; Liu, Guangqing] Beijing Univ Chem Technol, Dept Environm Sci & Technol, Beijing 100029, Peoples R China. [Zeng, Eddy Y.] Jinan Univ, Sch Environm, Guangzhou 510632, Guangdong, Peoples R China. [Xing, Baoshan] Univ Massachusetts, Stockbridge Sch Agr, Amherst, MA 01003 USA. [Shen, Guofeng] US EPA, NRMRL, Washington, DC 20460 USA. RP Tao, S (reprint author), Peking Univ, Coll Urban & Environm Sci, Lab Earth Surface Proc, Beijing 100871, Peoples R China.; Liu, GQ (reprint author), Beijing Univ Chem Technol, Dept Environm Sci & Technol, Beijing 100029, Peoples R China. EM gqliu@mail.buct.edu.cn; taos@pku.edu.cn RI Cheng, Hefa/A-1193-2007; OI Cheng, Hefa/0000-0003-4911-6971; SHEN, Guofeng/0000-0002-7731-5399 FU National Natural Science Foundation of China [41390240, 41130754, 41301554, 41571130010]; Ministry of Science and Technology [2015DFG92090]; Global Alliance for Clean Stoves FX Funding for this study was supported by the National Natural Science Foundation of China (41390240, 41130754, 41301554 and 41571130010) and Ministry of Science and Technology (2015DFG92090). G. Shen and S. Tao are partly supported by the Global Alliance for Clean Stoves. The authors thank the rural residents who helped us in field sample collection. NR 46 TC 0 Z9 0 U1 14 U2 14 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 EI 1873-2844 J9 ATMOS ENVIRON JI Atmos. Environ. PD DEC PY 2016 VL 147 BP 485 EP 491 DI 10.1016/j.atmosenv.2016.10.033 PG 7 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA ED0PE UT WOS:000388543600042 ER PT J AU Mills, LJ Henderson, WM Jayaraman, S Gutjahr-Gobell, RE Zaroogian, GE Horowitz, DB Laws, SC AF Mills, Lesley J. Henderson, W. Matthew Jayaraman, Saro Gutjahr-Gobell, Ruth E. Zaroogian, Gerald E. Horowitz, Doranne Borsay Laws, Susan C. TI Approaches for Predicting Effects of Unintended Environmental Exposure to an Endocrine Active Pharmaceutical, Tamoxifen SO ENVIRONMENTAL TOXICOLOGY LA English DT Article DE tamoxifen; endocrine active pharmaceuticals; metabolism; microsomes; fish; aromatase activity; reproduction; in vitro; in vivo; metabolomics ID MEDAKA ORYZIAS-LATIPES; FLOUNDER PARALICHTHYS-OLIVACEUS; TILAPIA OREOCHROMIS-NILOTICUS; BASS DICENTRARCHUS-LABRAX; HUMAN LIVER-MICROSOMES; IN-HOSPITAL EFFLUENTS; WATER TREATMENT WORKS; BREAST-CANCER-CELLS; SEX-DIFFERENTIATION; ANTICANCER DRUGS AB Tamoxifen is an endocrine-active pharmaceutical (EAP) that is used world-wide. Because tamoxifen is a ubiquitous pharmaceutical and interacts with estrogen receptors, a case study was conducted with this compound to (1) determine effects on reproductive endpoints in a nontarget species (i.e., a fish), (2) compare biologically-active metabolites across species, (3) assess whether in vitro assays predict in vivo results, and (4) investigate metabolomic profiles in tamoxifen-treated fish to better understand the biological mechanisms of tamoxifen toxicity. In reproductive assays, tamoxifen exposure caused a significant reduction in egg production and significantly increased ovarian aromatase activity in spawning adult cunner fish (Tautogolabrus adspersus). In plasma from tamoxifen-exposed cunner, the predominant metabolite was 4-hydroxytamoxifen, while in rats it was N-desmethyltamoxifen. Because 4-hydroxytamoxifen is a more biologically active metabolite than N-desmethyltamoxifen, this difference could result in a different level of risk for the two species. The results of in vitro assays with fish hepatic microsomes to assess tamoxifen metabolism did not match in vivo results, indicating probable differences in excretion of tamoxifen metabolites in fish compared with rats. For the first time, a complete in vitro characterization of the metabolism of tamoxifen using fish microsomes is presented. Furthermore, a metabolomic investigation of cunner gonad extracts demonstrates that tamoxifen alters the biochemical profile in this nontarget species. Understanding the consequence of tamoxifen exposure in nontarget species, and assessing the discrepancies between sex-and species-mediated endpoints, is a step toward understanding how to accurately assess the risks posed by EAPs, such as tamoxifen, in the aquatic environment. (C) 2015 Wiley Periodicals, Inc. C1 [Mills, Lesley J.; Jayaraman, Saro; Gutjahr-Gobell, Ruth E.; Zaroogian, Gerald E.; Horowitz, Doranne Borsay] US EPA, Atlantic Ecol Div, NHEERL, ORD, Narragansett, RI 02882 USA. [Henderson, W. Matthew] US EPA, Ecosyst Res Div, NERL, ORD, Athens, GA 30605 USA. [Laws, Susan C.] US EPA, Tox Assessment Div, NHEERL, ORD, Res Triangle Pk, NC 27711 USA. RP Mills, LJ (reprint author), US EPA, Atlantic Ecol Div, NHEERL, ORD, Narragansett, RI 02882 USA. EM mills.lesley@epa.gov NR 52 TC 0 Z9 0 U1 7 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1520-4081 EI 1522-7278 J9 ENVIRON TOXICOL JI Environ. Toxicol. PD DEC PY 2016 VL 31 IS 12 BP 1834 EP 1850 DI 10.1002/tox.22184 PG 17 WC Environmental Sciences; Toxicology; Water Resources SC Environmental Sciences & Ecology; Toxicology; Water Resources GA ED1PP UT WOS:000388617700014 ER PT J AU Feng, FF Jin, YF Duan, LJ Yan, Z Wang, SY Li, FF Liu, YY Samet, JM Wu, WD AF Feng, Feifei Jin, Yuefei Duan, Liju Yan, Zhen Wang, Shouying Li, Fangfang Liu, Yingying Samet, James M. Wu, Weidong TI Regulation of Ozone-Induced Lung Inflammation by the Epidermal Growth Factor Receptor in Mice SO ENVIRONMENTAL TOXICOLOGY LA English DT Article DE ozone; epidermal growth factor receptor; lung inflammation; TGF-alpha ID INDUCED AIRWAY HYPERRESPONSIVENESS; BRONCHIAL EPITHELIAL-CELLS; ACTIVATED PROTEIN-KINASE; EGF RECEPTOR; MEDIATED ACTIVATION; CARCINOMA-CELLS; EXPRESSION; EXPOSURE; MORTALITY; POLLUTION AB Human exposure to the highly reactive oxidant gas Ozone (O-3) is associated with inflammatory responses in the airway epithelium. The mechanisms responsible have not been fully elucidated. Epidermal growth factor receptor (EGFR) has previously been shown to play a critical role in the pathogenesis of lung inflammation. To define the role of EGFR in O-3-induced lung inflammation in mice. 40 BALB/c mice were exposed to filtered air (FA) or (0.25, 0.5, 1.00 ppm) O-3 for 3 h per day for 7 consecutive days. Levels of reactive oxygen species (ROS), EGF, and transforming growth factor alpha (TGF-alpha) in the bronchoalveolar lavage fluid (BALF) of mice were measured using ELISA. BALB/c mice were intratracheally instilled with the EGFR kinase inhibitor PD153035 2 h prior to O-3 exposure and every other day thereafter. Phosphorylation of EGFR (Y1068) in lung sections was determined using immunohistochemical staining and western blot 24 h after exposure. Inhalation of O-3 induced pronounced lung inflammation in a dose-dependent manner. Levels of ROS, TGF-alpha, and total proteins and cells in the BALF of mice exposed to 0.5 ppm or 1.0 ppm of O-3 were markedly elevated relative to those in the BALF of the mice exposed to FA. In addition, exposure to O-3 induced EGFR(Y1068) phosphorylation in the airway epithelium. Administration of PD153035 resulted in a significantly reduced lung inflammation as well as EGFR phosphorylation induced by O-3 exposure. Inhalation of O-3 leads to inflammatory responses that are dependent on the activation the EGFR in the airway epithelium. (C) 2015 Wiley Periodicals, Inc. C1 [Feng, Feifei; Jin, Yuefei; Duan, Liju; Yan, Zhen] Zhengzhou Univ, Coll Publ Hlth, Zhengzhou, Peoples R China. [Wang, Shouying; Li, Fangfang; Liu, Yingying; Wu, Weidong] Xinxiang Med Univ, Sch Publ Hlth, Xinxiang, Peoples R China. [Samet, James M.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC USA. RP Wu, WD (reprint author), Xinxiang Med Univ, Sch Publ Hlth, Xinxiang, Peoples R China. EM wdwu2013@126.com FU National Natural Science Foundation of China [81373030, 81402712]; Outstanding youth grant of Zhengzhou University [1421329082] FX Contract grant sponsor: National Natural Science Foundation of China.; Contract grant numbers: 81373030, 81402712; Contract grant sponsor: Outstanding youth grant of Zhengzhou University.; Contract grant number: 1421329082 NR 35 TC 0 Z9 0 U1 4 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1520-4081 EI 1522-7278 J9 ENVIRON TOXICOL JI Environ. Toxicol. PD DEC PY 2016 VL 31 IS 12 BP 2016 EP 2027 DI 10.1002/tox.22202 PG 12 WC Environmental Sciences; Toxicology; Water Resources SC Environmental Sciences & Ecology; Toxicology; Water Resources GA ED1PP UT WOS:000388617700031 ER PT J AU Mayasich, SA Bemis, LT Clarke, BL AF Mayasich, Sally A. Bemis, Lynne T. Clarke, Benjamin L. TI DNA methylation in a sea lamprey vasotocin receptor gene promoter correlates with tissue- and life-stage-specific mRNA expression SO COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY LA English DT Article DE DNA methylation; Estrogen response element; Oxytocin receptor; Sea lamprey; Vasotocin receptor; Zinc-finger transcription factors ID PETROMYZON-MARINUS; NEURAL CREST; TRANSCRIPTION; EVOLUTION; ORIGIN AB The jawless vertebrate sea lamprey (Petromyzon marinus) genome has a different structure from both invertebrates and jawed vertebrates featuring high guanine-cytosine (GC) content. This raises the question of whether DNA methylation of cytosine-guanine (CpG) dinucleotides could function to regulate lamprey gene transcription. We previously characterized a lamprey arginine vasotocin (AVT) receptor gene (Pm807) possessing characteristics of both arginine vasopressin (AVP) VIA and oxytocin (OXT) receptor genes of jawed vertebrates. Lamprey Pm807 mRNA is highly expressed in adult heart and larval liver but not expressed in adult liver. Using high-resolution melt (HRM) PCR on bisulfite-converted DNA, we pinpointed a region with tissue specific differences in DNA melt characteristics, indicating differences in methylation level. Sequencing revealed a pattern of methylation at specific CpGs at consistently higher levels in adult heart and larval liver than adult liver. These CpGs are associated with putative transcription factor binding sequences organized similarly to functional OXTR promoters in mammals, suggesting functional similarity in lamprey gene transcription regulation. (C) 2016 Elsevier Inc. All rights reserved. C1 [Mayasich, Sally A.; Bemis, Lynne T.; Clarke, Benjamin L.] Univ Minnesota Duluth, Dept Biomed Sci, Sch Med, 1035 Univ Dr, Duluth, MN 55812 USA. RP Mayasich, SA (reprint author), US EPA, Midcontinent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA. EM mayasich.sally@epa.gov FU Office of the Vice President for Research, University of Minnesota FX This research was supported by a Grant-in-Aid of Research, Artistry and Scholarship from the Office of the Vice President for Research, University of Minnesota. We thank Olivia Mayasich for technical assistance, Drs. Kevin Diebel and Aubie Shaw for experimental suggestions, and Drs. Sara Zimmer, Allen Mensinger, and Michael Hornung for review of the manuscript. NR 33 TC 1 Z9 1 U1 4 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1096-4959 EI 1879-1107 J9 COMP BIOCHEM PHYS B JI Comp. Biochem. Physiol. B-Biochem. Mol. Biol. PD DEC PY 2016 VL 202 BP 56 EP 66 DI 10.1016/j.cbpb.2016.07.007 PG 11 WC Biochemistry & Molecular Biology; Zoology SC Biochemistry & Molecular Biology; Zoology GA ED0OQ UT WOS:000388542200008 PM 27497665 ER PT J AU Beauchamp, J Pleil, J Risby, T Dweik, R AF Beauchamp, J. Pleil, J. Risby, T. Dweik, R. TI Report from IABR Breath Summit 2016 in Zurich, Switzerland SO JOURNAL OF BREATH RESEARCH LA English DT Editorial Material ID EXHALED NITRIC-OXIDE; ASTHMATIC-PATIENTS; RESPIRATORY-TRACT; NASAL; AIR; BIOMARKERS; EMISSIONS; HUMANS; SKIN C1 [Beauchamp, J.] Fraunhofer Inst Proc Engn & Packaging IVV, Dept Sensory Analyt, D-85354 Freising Weihenstephan, Germany. [Pleil, J.] US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27709 USA. [Risby, T.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Environm Hlth Sci, Baltimore, MD 21205 USA. [Dweik, R.] Cleveland Clin, Resp Inst, Dept Pulm Med, Cleveland, OH 44195 USA. RP Beauchamp, J (reprint author), Fraunhofer Inst Proc Engn & Packaging IVV, Dept Sensory Analyt, D-85354 Freising Weihenstephan, Germany. EM jonathan.beauchamp@ivv.fraunhofer.de; pleil.joachim@epa.gov; trisby1@jhu.edu; dweikr@ccf.org NR 53 TC 0 Z9 0 U1 2 U2 2 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 1752-7155 EI 1752-7163 J9 J BREATH RES JI J. Breath Res. PD DEC PY 2016 VL 10 IS 4 AR 049001 DI 10.1088/1752-7155/10/4/049001 PG 5 WC Biochemical Research Methods; Respiratory System SC Biochemistry & Molecular Biology; Respiratory System GA EC9OX UT WOS:000388475000001 ER PT J AU Sell, TK Boddie, C McGinty, EE Pollack, K Smith, KC Burke, TA Rutkow, L AF Sell, Tara Kirk Boddie, Crystal McGinty, Emma E. Pollack, Keshia Smith, Katherine Clegg Burke, Thomas A. Rutkow, Lainie TI News media coverage of US Ebola policies: Implications for communication during future infectious disease threats SO PREVENTIVE MEDICINE LA English DT Article DE Disease outbreaks; Hemorrhagic fever; Ebola; Mass media; Public health; Policy ID UNITED-STATES; POLITICS AB The Ebola outbreak of 2014-2015 raised concerns about the disease's potential spread in the U.S. and received significant news media coverage. Prior research has shown that news media coverage of policy options can influence public opinion regarding those policies, as well as public attitudes toward the broader social issues and target populations addressed by such policies. To assess news media coverage of Ebola policies, the content of U.S.-focused news stories (n=1262) published between July 1 and November 30, 2014 from 12 news sources was analyzed for 13 policy-related messages. Eight-two percent of news stories mentioned one or more policy-related messages. The most frequently appearing policy-related messages overall were those about isolation (47%) and quarantine (40%). The least frequently mentioned policy-related message described dividing potentially exposed persons into distinct groups based on their level of Ebola risk in order to set different levels of restrictions (5%). Message frequency differed depending on whether news sources were located in an area that experienced an Ebola case or controversy, by news sources' political ideological perspective, and by type of news source (print and television). All policy-related messages showed significant increases in frequency after the first case of Ebola was diagnosed in the U.S. on September 30, 2014, with the exception of messages related to isolation, which showed a significant decrease. Results offer insight into how the news media covers policies to manage emerging disease threats. (C) 2016 Elsevier Inc. All rights reserved. C1 [Sell, Tara Kirk; Boddie, Crystal; McGinty, Emma E.; Pollack, Keshia; Rutkow, Lainie] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, 624 N Broadway, Baltimore, MD 21205 USA. [Sell, Tara Kirk; Boddie, Crystal] UPMC Ctr Hlth Secur, 621 E Pratt St Suite 210, Baltimore, MD 21202 USA. [Smith, Katherine Clegg] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Behav & Soc, 624 N Broadway, Baltimore, MD 21205 USA. [Burke, Thomas A.] US EPA, 1200 Penn Ave,NW, Washington, DC 20460 USA. RP Sell, TK (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, Room 513,624 N Broadway, Baltimore, MD 21205 USA. EM tksell@upmc.edu FU Johns Hopkins Sommer Scholars Program FX The authors would like to acknowledge Dr. Amesh Adalja and Matthew Watson for their review of the initial coding instrument. Support for this research was provided to TKS by the Johns Hopkins Sommer Scholars Program. NR 34 TC 0 Z9 0 U1 8 U2 8 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0091-7435 EI 1096-0260 J9 PREV MED JI Prev. Med. PD DEC PY 2016 VL 93 BP 115 EP 120 DI 10.1016/j.ypmed.2016.09.016 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA EC8IA UT WOS:000388383700018 PM 27664539 ER PT J AU Druwe, IL Burgoon, LD AF Druwe, Ingrid L. Burgoon, Lyle D. TI Response to Cohen et al. (2016) regarding response to Druwe and Burgoon SO ARCHIVES OF TOXICOLOGY LA English DT Letter ID INORGANIC ARSENIC EXPOSURE; LUNG-TUMORS; ARCH TOXICOL; MICE C1 [Druwe, Ingrid L.] US EPA, Oak Ridge Inst Sci & Educ, Res Participat Program, Natl Ctr Environm Assessment,Off Res & Dev, Res Triangle Pk, NC 27709 USA. [Burgoon, Lyle D.] US Army Engineer Res & Dev Ctr, Res Triangle Pk, NC USA. RP Druwe, IL (reprint author), US EPA, Oak Ridge Inst Sci & Educ, Res Participat Program, Natl Ctr Environm Assessment,Off Res & Dev, Res Triangle Pk, NC 27709 USA. EM druwe.ingrid@epa.gov OI Burgoon, Lyle/0000-0003-4977-5352 NR 10 TC 0 Z9 0 U1 2 U2 2 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0340-5761 EI 1432-0738 J9 ARCH TOXICOL JI Arch. Toxicol. PD DEC PY 2016 VL 90 IS 12 BP 3131 EP 3132 DI 10.1007/s00204-016-1858-9 PG 2 WC Toxicology SC Toxicology GA EB9FH UT WOS:000387697600019 PM 27717971 ER PT J AU Butler, T Vermeylen, F Lehmann, CM Likens, GE Puchalski, M AF Butler, T. Vermeylen, F. Lehmann, C. M. Likens, G. E. Puchalski, M. TI Increasing ammonia concentration trends in large regions of the USA derived from the NADP/AMoN network SO ATMOSPHERIC ENVIRONMENT LA English DT Article; Proceedings Paper CT 9th International Acid Rain Conference (Acid Rain) CY OCT, 2015 CL Rochester, NY DE Reduced nitrogen; Ammonia emissions; Ammonia trends; Atmospheric nitrogen; Ammonia monitoring; Acid Rain 2015 ID UNITED-STATES; DEPOSITION; EMISSIONS; NITROGEN; AEROSOL; SITES AB Data from bi-weekly passive samplers from 18 of the longest operating National Atmospheric Deposition Program's (NADP) Ammonia Monitoring Network (AMoN) sites (most operating from 2008 to 2015) show that concentrations of NH3 have been increasing (p-value < 0.0001) over large regions of the USA. This trend is occurring at a seasonal and annual level of aggregation. Using random coefficient models (RCM), the mean slope for the 18 sites combined shows an increase of NH3 concentration of +7% per year, with a 95% confidence interval (C.I.) from +5% to +9% per year. Travel blank corrected data using the same approach show increasing NH3 concentrations of +9% (95% C.I. +5% to +13%) per year. During a comparable period (2008-2014) NADP precipitation chemistry sites in the same regions show significant increasing (p-value = 0.0001) precipitation NH4+ concentrations trends for all sites combined of +5% (95% C.I. +3% to +7%) per year. Emissions inventory data for the study period show nearly constant rates of NH3 emissions, but large reductions in NOx and SO2 emissions. Seasonal air quality data from the Clean Air Status and Trends Network (CASTNET) sites in these regions show significant declines in atmospheric particulate SO42- and NH4+, and particulate NO3- plus HNO3 (total NO3-) during the same period. Less formation of acidic SO4 and NO3, due to reduced SO2 and NOx emissions, provide less substrate to interact with NH3 and form particulate ammonium species. Thus, concentrations of NH3 can increase in the atmosphere even if emissions remain constant. A likely result may be more localized deposition of NH3, as opposed to the more long-range transport and deposition of ammonium nitrate (NH4NO3) and sulfate (NH4)(2)SO4). Additionally, the spatial distribution of wet and dry acidic deposition will be impacted. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Butler, T.] Cornell Univ, Dept Ecol & Evolutionary Biol, Ithaca, NY 14853 USA. [Butler, T.; Likens, G. E.] Cary Inst Ecosyst Studies, Box AB, Millbrook, NY 12545 USA. [Vermeylen, F.] Cornell Univ, Off Stat Consulting, Ithaca, NY 14853 USA. [Lehmann, C. M.] NADP Program Off, Illinois State Water Survey, Champaign, IL 61820 USA. [Likens, G. E.] Univ Connecticut, Dept Ecol & Evolutionary Biol, Storrs, CT 06269 USA. [Puchalski, M.] US EPA, Off Air Programs, Washington, DC 20460 USA. RP Butler, T (reprint author), Cornell Univ, 211 Rice Hall, Ithaca, NY 14853 USA. EM tjb2@cornell.edu NR 31 TC 0 Z9 0 U1 14 U2 14 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 EI 1873-2844 J9 ATMOS ENVIRON JI Atmos. Environ. PD DEC PY 2016 VL 146 SI SI BP 132 EP 140 DI 10.1016/j.atmosenv.2016.06.033 PG 9 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA EC3UG UT WOS:000388051700012 ER PT J AU Ren, XR Luke, WT Kelley, P Cohen, MD Artz, R Olson, ML Schmeltz, D Puchalski, M Goldberg, DL Ring, A Mazzuca, GM Cummings, KA Wojdan, L Preaux, S Stehr, JW AF Ren, Xinrong Luke, Winston T. Kelley, Paul Cohen, Mark D. Artz, Richard Olson, Mark L. Schmeltz, David Puchalski, Melissa Goldberg, Daniel L. Ring, Allison Mazzuca, Gina M. Cummings, Kristin A. Wojdan, Lisa Preaux, Sandra Stehr, Jeff W. TI Atmospheric mercury measurements at a suburban site in the Mid-Atlantic United States: Inter-annual, seasonal and diurnal variations and source-receptor relationships SO ATMOSPHERIC ENVIRONMENT LA English DT Article; Proceedings Paper CT 9th International Acid Rain Conference (Acid Rain) CY OCT, 2015 CL Rochester, NY DE Atmospheric mercury; Gaseous elemental mercury; Gaseous oxidized mercury; Particulate-bound mercury; Trend; HYSPLIT ID GASEOUS OXIDIZED MERCURY; COASTAL; SPECIATION; EMISSIONS; EXPOSURE; MARINE; RAMIX; GEM; HG AB Different atmospheric mercury forms have been measured at a suburban site in Beltsville, Maryland in the Mid-Atlantic United States since 2007 to investigate their inter-annual, seasonal and diurnal variabilities. Average concentrations and standard deviations of hourly measurements from 2007 to 2015 were 1.41 +/- 0.23 ng m(-3) for gaseous elemental mercury (GEM), 4.6 +/- 33.7 pg m(-3) for gaseous oxidized mercury (GOM), and 8.6 +/- 56.8 pg m(-3) for particulate-bound mercury (PBM). Observations show that on average, the rates of decrease were 0.020 +/- 0.007 ng m(-3) yr(-1) (or 13 +/- 0.5% yr(-1), statistically significant, p-value < 0.01) for GEM, 0.54 +/- 0.19 pg m(-3) yr(-1) (or 7.3 +/- 2.6% yr(-1), statistically significant, p-value < 0.01) for GOM, and 0.15 +/- 0.35 pg m(-3) yr(-1) (or 1.6 +/- 3.8% yr(-1), statistically insignificant, p-value > 0.01) for PBM over this nine-year period. In addition, the collocated annual mercury wet deposition decreased at a rate of 0.51 +/- 0.24 mu g m(-2) yr(-2) (or 4.2 +/- 1.9% yr(-1), statistically insignificant, p-value > 0.01). Diurnal variation of GEM shows a slight peak in the morning, likely due to the shallow boundary layer. Seasonal variation of GEM shows lower levels in fall. Both diurnal variations of GOM and PBM show peaks in the afternoon likely due to the photochemical production of reactive mercury from the oxidation of GEM and the influence of boundary layer processes. Seasonally, GOM measurements show high levels in spring and constant low levels in the other three seasons, while PBM measurements exhibit higher levels from late fall to early spring and lower levels frdm late spring to fall. These measurement data were analyzed using the HYSPLIT back trajectory model in order to examine possible source-receptor relationships at this suburban site. Trajectory frequency analysis shows that high GEM/GOM/PBM events were generally associated with high frequencies of the trajectories passing through areas with high mercury emissions, while low GEM/GOM/PBM levels were largely associated the trajectories passing through relatively clean areas. This study indicates that local and regional sources appear to have a significant impact on the site and these impacts appear to have changed over time, as the local/regional emissions have been reduced. (C) 2016 The Authors. Published by Elsevier Ltd. C1 [Ren, Xinrong; Luke, Winston T.; Kelley, Paul; Cohen, Mark D.; Artz, Richard] NOAA, Air Resources Lab, 5830 Univ Res Court, College Pk, MD 20740 USA. [Ren, Xinrong; Kelley, Paul] Univ Maryland, Cooperat Inst Climate & Satellites, College Pk, MD 20742 USA. [Ren, Xinrong; Goldberg, Daniel L.; Ring, Allison; Mazzuca, Gina M.; Cummings, Kristin A.; Wojdan, Lisa; Preaux, Sandra; Stehr, Jeff W.] Univ Maryland, Dept Atmospher & Ocean Sci, College Pk, MD 20742 USA. [Cohen, Mark D.] Univ Illinois, Illinois State Water Survey, Champaign, IL USA. [Schmeltz, David; Puchalski, Melissa] US EPA, Clean Air Markets Div, Washington, DC 20460 USA. [Goldberg, Daniel L.] Argonne Natl Lab, Div Energy Syst, 9700 S Cass Ave, Argonne, IL 60439 USA. [Wojdan, Lisa] Iroquois High Sch, Elma, NY USA. [Preaux, Sandra] Stinger Ghaffarian Technol, Greenbelt, MD USA. [Stehr, Jeff W.] Booz Allen Hamilton, Washington, DC USA. RP Ren, XR (reprint author), NOAA, Air Resources Lab, 5830 Univ Res Court, College Pk, MD 20740 USA. EM xinrong.ren@noaa.gov RI Ren, Xinrong/E-7838-2015; OI Ren, Xinrong/0000-0001-9974-1666; Cohen, Mark/0000-0003-3183-2558 NR 37 TC 2 Z9 2 U1 10 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 EI 1873-2844 J9 ATMOS ENVIRON JI Atmos. Environ. PD DEC PY 2016 VL 146 SI SI BP 141 EP 152 DI 10.1016/j.atmosenv.2016.08.028 PG 12 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA EC3UG UT WOS:000388051700013 ER PT J AU Hawkins, CP Yuan, LL AF Hawkins, Charles P. Yuan, Lester L. TI Multitaxon distribution models reveal severe alteration in the regional biodiversity of freshwater invertebrates SO FRESHWATER SCIENCE LA English DT Article DE biodiversity status; multi-species distribution models; freshwater invertebrates; environmental alteration ID SPECIES DISTRIBUTION MODELS; PREDICTIVE MODELS; LAND-USE; MACROINVERTEBRATE FAUNA; BRITISH BUTTERFLIES; IMPERFECT DETECTION; ENVIRONMENTAL DNA; COMMUNITY; ASSESSMENTS; STREAMS AB Knowledge of current and historical conditions is needed to guide conservation and restoration policies, but such information is lacking for most taxa. This problem is especially severe for small, inconspicuous taxa, such as the thousands of invertebrate species that inhabit stream and other freshwater ecosystems. We describe a novel application of River Invertebrate Prediction and Classification System (RIVPACS)-type multitaxon distribution models that, when applied to the biological survey data routinely collected in support of water-quality monitoring programs, can quantify the regional biodiversity status of hundreds of taxa. We used models developed for 2 stream data sets (North Carolina and the Mid-Atlantic Highlands, USA) to illustrate the potential of this approach. The models were calibrated with data collected from sites considered to be in reference condition and predict how probabilities of capture for each taxon in a data set vary across natural environmental gradients. When applied to survey data from multiple sites, predicted probabilities of capture can be summed across sites to estimate the taxon-specific frequencies of collection (F-e) expected under reference conditions. Comparison of observed frequencies (F-o) with F-e provides a quantitative measure of how individual taxon frequencies of collection have shifted relative to estimated reference conditions. In these 2 data sets, F-e was statistically different from F-o for >70% of taxa, implying wholesale changes have occurred in the stream invertebrate biodiversity of both regions. F-o was 50% of the females in the 100ngl(-1) treatment. Based on these results, the LAGDA performed adequately to evaluate apical effects of chronic exposure to two endocrine-active compounds and is the first standardized amphibian multiple life stage toxicity test to date. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. The Larval Amphibian Growth and Development Assay (LAGDA) is a globally harmonized test guideline designed to evaluate apical effects of chronic chemical exposure with emphasis on endocrine disruption. Xenoestrogen, 4-tert-octylphenol, and xenoandrogen, 17-trenbolone, were tested to evaluate the performance of the assay. Chemical-specific effects on thyroid homeostasis and reproductive development were identified. Notably, Mullerian duct development was the most sensitive endpoint affected by both chemicals. The LAGDA performed adequately to evaluate apical effects of chronic exposure to two endocrine-active compounds. C1 [Haselman, Jonathan T.; Kosian, Patricia A.; Korte, Joseph J.; Olmstead, Allen W.; Johnson, Rodney D.; Degitz, Sigmund J.] US EPA, Midcontinent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA. [Iguchi, Taisen] Natl Inst Nat Sci, Okazaki Inst Integrat Biosci, Natl Inst Basic Biol, 5-1 Higashiyama, Okazaki, Aichi 4448787, Japan. RP Haselman, JT (reprint author), US EPA, Midcontinent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA. EM haselman.jon@epa.gov FU U.S. EPA FX The authors would like to thank Chad Blanksma (Oak Ridge Institute for Science and Education) and Dr Jeffrey Wolf (Experimental Pathology Laboratories, Inc.) for histotechnical support and histopathology assessments, respectively, and Joe Swintek (Badger Technical Services) for extensive statistical support and advice. Lindsey Blake, Shane Zavodnik, Kathryn Lillegard, Ben Heggested, Erica Nevalainen, Evan Eid, Luke Dahlin and Stephanie Hall (Student Contract Services) provided laboratory technical support with husbandry, exposure systems, sampling and sample analyses. The authors would also like to thank Kevin Flynn for thoughtful comments and suggestions to improve this manuscript. This work was funded by the U.S. EPA; this paper has been reviewed according to ORD guidelines, but the statements made do not represent views of the U.S. EPA, nor does mention of trade names indicate endorsement by the federal government. NR 45 TC 0 Z9 0 U1 8 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0260-437X EI 1099-1263 J9 J APPL TOXICOL JI J. Appl. Toxicol. PD DEC PY 2016 VL 36 IS 12 BP 1639 EP 1650 DI 10.1002/jat.3330 PG 12 WC Toxicology SC Toxicology GA DZ3XF UT WOS:000385782200013 PM 27143402 ER PT J AU Buckley, J AF Buckley, Jenifer TI Interpersonal Skills in the Practice of Food Safety Inspections: A Study of. Compliance Assistance SO JOURNAL OF ENVIRONMENTAL HEALTH LA English DT Article ID ENFORCEMENT AB Conducting food safety inspections requires interpersonal skills and technical expertise. This requirement is particularity important for agencies that adopt a compliance assistance approach by encouraging inspectors to assist industry in finding solutions to violations. This study describes a study of inspections that were conducted by inspectors from the Michigan Department of Agriculture and Rural Development Food and Dairy Division at small-scale processing facilities. Interactions between inspectors and small processors were explored through a qualitative, ethnographic approach using interviews and field observations. Inspectors emphasized the importance of interpersonal skills such as communication, patience, empathy, respect, and consideration in conducting inspections. This study examines how these skills were applied, how inspectors felt they improved compliance, the experiences through which inspectors attained these skills, and the training for which they expressed a need. These results provide new insights into the core competencies required in conducting inspections, and they provide the groundwork for further research. C1 [Buckley, Jenifer] US EPA, Amer Assoc Adv Sci, Washington, DC 20460 USA. RP Buckley, J (reprint author), US EPA, Amer Assoc Adv Sci, Washington, DC 20460 USA. EM jenifer.a.buckley@gmail.com FU University Distinguished Fellowship from Michigan State University; National Science Foundation [SES-1230878]; Sustainable Agriculture Research and Education program - U.S. Department of Agriculture (USDA), National Institute of Food and Agriculture [GNC10-134]; W.K. Kellogg Foundation FX I thank Kevin Besey of MDARD and Jim Bingen of Michigan State University for reviewing earlier drafts of this article and for their ongoing engagement in this work. I am grateful to the study's participants and project advisory committee. I thank Larry Busch, Chris Peterson, and Paul Thompson for their guidance. This project was supported by a University Distinguished Fellowship from Michigan State University; the National Science Foundation under grant number SES-1230878; the Sustainable Agriculture Research and Education program, which is funded by the U.S. Department of Agriculture (USDA), National Institute of Food and Agriculture, under project number GNC10-134; and funds from a grant to Michigan State University from the W.K. Kellogg Foundation to establish a pasture based dairy program at the Kellogg Biological Station. Any opinions, findings, conclusions, or recommendations expressed within this article do not necessarily reflect the views of the above individuals, participants, or funders. USDA is an equal opportunity provider and employer. NR 15 TC 0 Z9 0 U1 1 U2 1 PU NATL ENVIRON HEALTH ASSOC PI DENVER PA 720 S COLORADO BLVD SUITE 970, SOUTH TOWER, DENVER, CO 80246 USA SN 0022-0892 J9 J ENVIRON HEALTH JI J. Environ. Health PD DEC PY 2016 VL 79 IS 5 BP 8 EP 12 PG 5 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA EB8IZ UT WOS:000387636000002 ER PT J AU Champagne, TM Barlock, RR Ghimire, SR Barkdoll, BD Gonzalez-Castro, JA Deaton, L AF Champagne, Ted M. Barlock, Rachael R. Ghimire, Santosh R. Barkdoll, Brian D. Gonzalez-Castro, Juan A. Deaton, Larry TI Scour Reduction by Air Injection Downstream of Stilling Basins: Optimal Configuration Determination by Experimentation SO JOURNAL OF IRRIGATION AND DRAINAGE ENGINEERING LA English DT Article DE Hydraulics; Countermeasures; Stilling basin; Turbulence; Sediment; Water; Canal ID PLUNGE POOL SCOUR; BUBBLE PLUMES; WATER JETS; BED; FLOW; HYDRAULICS; AERATION; VELOCITY; SEEPAGE; HEADCUT AB Hydraulic structure undermining attributable to scour can cause structural damage or collapse. Experiments were performed in a laboratory channel on scour downstream of a stilling basin of a low-head spillway to ascertain the feasibility of air injection for scour reduction, an idea that has not been previously attempted. Various hydraulic flow conditions without air injection indicate that the condition of stilling basin water elevation lower than the spillway crest, under high headwater-to-tailwater depth ratio, results in the deepest scour. Over 120 experiments were performed to determine the optimal parameters for scour reduction by air injection. It was found that optimal scour-reducing conditions consist of (1) air injection at an air-to-water velocity ratio of 251, (2) vertical air injection at the same elevation as the stilling basin exit point, (3) using diffuser hole diameters corresponding to a ratio of air-to-water velocity equal to 251 spanning the entire width of the stilling basin, and (4) a diffuser hole spacing 0.04 times the diffuser width. Scour can thus be reduced by approximately 59% near the structure. Air compressors and diffuser pipe diameter and hole sizes corresponding to these conditions would be required in prototype installations. (C) 2016 American Society of Civil Engineers. C1 [Champagne, Ted M.; Barlock, Rachael R.; Barkdoll, Brian D.] Michigan Technol Univ, Dept Civil & Environm Engn, 1400 Townsend Blvd, Houghton, MI 49931 USA. [Ghimire, Santosh R.] US EPA, 960 Coll Stn Rd, Athens, GA 30605 USA. [Gonzalez-Castro, Juan A.] South Florida Water Management Dist, 3301 Gun Club Rd, W Palm Beach, FL 33406 USA. [Deaton, Larry] NRI, 346 South Killian Dr, Lake Park, FL 33403 USA. RP Barkdoll, BD (reprint author), Michigan Technol Univ, Dept Civil & Environm Engn, 1400 Townsend Blvd, Houghton, MI 49931 USA. EM barkdoll@mtu.edu FU South Florida Water Management District FX This study was partially funded by the South Florida Water Management District. The opinion expressed or statements made herein are solely those of the authors and do not reflect the views of the agencies of the authors' affiliations. NR 53 TC 0 Z9 0 U1 4 U2 4 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9437 EI 1943-4774 J9 J IRRIG DRAIN ENG JI J. Irrig. Drainage Eng-ASCE PD DEC PY 2016 VL 142 IS 12 AR 04016067 DI 10.1061/(ASCE)IR.1943-4774.0001108 PG 9 WC Agricultural Engineering; Engineering, Civil; Water Resources SC Agriculture; Engineering; Water Resources GA EC2BL UT WOS:000387914200011 ER PT J AU Ji, DS Gao, WK Zhang, JK Morino, Y Zhou, LX Yu, PF Li, Y Sun, JR Ge, BZ Tang, GQ Sun, YL Wang, YS AF Ji, Dongsheng Gao, Wenkang Zhang, Junke Morino, Yu Zhou, Luxi Yu, Pengfei Li, Ying Sun, Jiaren Ge, Baozhu Tang, Guiqian Sun, Yele Wang, Yuesi TI Investigating the evolution of summertime secondary atmospheric pollutants in urban Beijing SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE O-3; O-x; Photochemical production; Oxygenated organic aerosol ID ORGANIC AEROSOL FORMATION; PHOTOCHEMICAL SMOG; SOURCE ATTRIBUTION; NORTHERN CHINA; AIR-POLLUTION; OZONE; TRENDS; PM2.5; LAYER AB Understanding the formation of tropospheric ozone (O-3) and secondary particulates is essential for controlling secondary pollution in megacities. Intensive observations were conducted to investigate the evolution of O-3, nitrate (NO3-), sulfate (SO42-) and oxygenated organic aerosols ((OOAs), a proxy for secondary organic aerosols) and the interactions between O-3, NOx oxidation products (NOz) and OOA in urban Beijing in August 2012. The O-3 concentrations exhibited similar variations at both the urban and urban background sites in Beijing. Regarding the O-3 profile, the O-3 concentrations increased with increasing altitude. The peaks in O-3 on the days exceeding the 1 h or 8 h O-3 standards (polluted days) were substantially wider than those on normal days. Significant increases in the NOz mixing ratio (i.e., NOy - NOx) were observed between the morning and early afternoon, which were consistent with the increasing oxidant level. A discernable NO3-peak was also observed in the morning on the polluted days, and this peak was attributed to vertical mixing and strong photochemical production. In addition, a SO(4)(2-)peak at 18:00 was likely caused by a combination of local generation and regional transport. The OOA-concentration cycle exhibited two peaks at approximately 10:00 and 19:00. The OOA concentrations were correlated well with SO42-([OOA] = 0.55 x [SO42-] + 2.1, r(2) = 0.69) because they both originated from secondary transformations that were dependent on the ambient oxidization level and relative humidity. However, the slope between OOA and SO42- was only 0.35, which was smaller than the slope observed for all of the OOA and SO42- data, when the RH ranged from 40 to 50%. In addition, a photochemical episode was selected for analysis. The results showed that regional transport played an important role in the evolution of the investigated secondary pollutants. The measured OOA and O-x concentrations were well correlated at the daily scale, whereas the hourly OOA and O-x concentrations were insignificantly correlated in urban Beijing. The synoptic situation and the differences in the VOC oxidation contributing to O-3 and SOAs may have resulted in the differences among the correlations between OOA and O-x at different time scale. We calculated OOA production rates using the photochemical age (defined as -log(10)(NOx/NOy)) in urban plumes. The CO-normalized OOA concentration increased with increasing photochemical age, with production rates ranging from 1.1 to 8.5 mu g m(-3) ppm(-1) h(-1) for the plume from the NCP. (C) 2016 Elsevier B.V. All rights reserved. C1 [Ji, Dongsheng; Gao, Wenkang; Zhang, Junke; Li, Ying; Ge, Baozhu; Tang, Guiqian; Sun, Yele; Wang, Yuesi] Chinese Acad Sci, Inst Atmospher Phys, State Key Lab Atmospher Boundary Layer Phys & Atm, Beijing, Peoples R China. [Gao, Wenkang] Univ Chinese Acad Sci, Beijing, Peoples R China. [Morino, Yu; Li, Ying] Natl Inst Environm Studies, Ctr Reg Environm Res, Tsukuba, Ibaraki, Japan. [Zhou, Luxi] Univ Helsinki, Dept Phys, Helsinki, Finland. [Yu, Pengfei] NOAA, Boulder, CO USA. [Yu, Pengfei] Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA. [Sun, Jiaren] Minist Environm Protect, South China Inst Environm Sci, Guangzhou, Guangdong, Peoples R China. [Zhou, Luxi] US EPA, Res Triangle Pk, NC 27711 USA. RP Ji, DS; Wang, YS (reprint author), Chinese Acad Sci, Inst Atmospher Phys, State Key Lab Atmospher Boundary Layer Phys & Atm, Beijing, Peoples R China. EM jds@mail.iap.ac.cn; wys@mail.iap.ac.cn RI Yu, Pengfei/S-4596-2016; Zhou, Luxi/S-4947-2016; Tang, Guiqian/E-5451-2016; Zhang, Junke/E-8284-2016; Sun, Yele/F-1314-2010; Manager, CSD Publications/B-2789-2015 OI Yu, Pengfei/0000-0002-2774-1058; Zhou, Luxi/0000-0001-7364-741X; Tang, Guiqian/0000-0002-4381-5344; Zhang, Junke/0000-0003-1595-5136; Sun, Yele/0000-0003-2354-0221; FU Beijing Natural Science Foundation [8142034]; Strategic Priority Research Program (B) of the Chinese Academy of Sciences [XDB05020501, XDB05030203] FX This work was supported by the Beijing Natural Science Foundation (8142034) and the Strategic Priority Research Program (B) of the Chinese Academy of Sciences (Grants XDB05020501 and XDB05030203). NR 49 TC 0 Z9 0 U1 40 U2 40 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD DEC 1 PY 2016 VL 572 BP 289 EP 300 DI 10.1016/j.scitotenv.2016.07.153 PG 12 WC Environmental Sciences SC Environmental Sciences & Ecology GA EC0RA UT WOS:000387807200030 PM 27505262 ER PT J AU Nasari, MM Szyszkowicz, M Chen, H Crouse, D Turner, MC Jerrett, M Pope, CA Hubbell, B Fann, N Cohen, A Gapstur, SM Diver, WR Stieb, D Forouzanfar, MH Kim, SY Olives, C Krewski, D Burnett, RT AF Nasari, Masoud M. Szyszkowicz, Mieczyslaw Chen, Hong Crouse, Daniel Turner, Michelle C. Jerrett, Michael Pope, C. Arden, III Hubbell, Bryan Fann, Neal Cohen, Aaron Gapstur, Susan M. Diver, W. Ryan Stieb, David Forouzanfar, Mohammad H. Kim, Sun-Young Olives, Casey Krewski, Daniel Burnett, Richard T. TI A class of non-linear exposure-response models suitable for health impact assessment applicable to large cohort studies of ambient air pollution SO AIR QUALITY ATMOSPHERE AND HEALTH LA English DT Article DE Air pollution; Cohort; Exposure; Mortality; Particulate matter ID FINE PARTICULATE MATTER; LONG-TERM EXPOSURE; CARDIOVASCULAR MORTALITY; GLOBAL BURDEN; RISK; ASSOCIATIONS; DISEASE; PM2.5 AB The effectiveness of regulatory actions designed to improve air quality is often assessed by predicting changes in public health resulting from their implementation. Risk of premature mortality from long-term exposure to ambient air pollution is the single most important contributor to such assessments and is estimated from observational studies generally assuming a log-linear, no-threshold association between ambient concentrations and death. There has been only limited assessment of this assumption in part because of a lack of methods to estimate the shape of the exposure-response function in very large study populations. In this paper, we propose a new class of variable coefficient risk functions capable of capturing a variety of potentially non-linear associations which are suitable for health impact assessment. We construct the class by defining transformations of concentration as the product of either a linear or log-linear function of concentration multiplied by a logistic weighting function. These risk functions can be estimated using hazard regression survival models with currently available computer software and can accommodate large population-based cohorts which are increasingly being used for this purpose. We illustrate our modeling approach with two large cohort studies of long-term concentrations of ambient air pollution and mortality: the American Cancer Society Cancer Prevention Study II (CPS II) cohort and the Canadian Census Health and Environment Cohort (CanCHEC). We then estimate the number of deaths attributable to changes in fine particulate matter concentrations over the 2000 to 2010 time period in both Canada and the USA using both linear and non-linear hazard function models. C1 [Nasari, Masoud M.; Szyszkowicz, Mieczyslaw; Crouse, Daniel; Stieb, David; Burnett, Richard T.] Hlth Canada, Environm Hlth Sci & Res Bur, 200 Eglantine Driveway, Ottawa, ON K1A 0K9, Canada. [Chen, Hong] Publ Hlth Ontario, Oakville, ON, Canada. [Turner, Michelle C.; Krewski, Daniel] Univ Ottawa, Inst Populat Hlth, McLaughlin Ctr Populat Hlth Risk Assessment, Ottawa, ON, Canada. [Turner, Michelle C.] Ctr Res Environm Epidemiol CREAL, Madrid, Spain. [Turner, Michelle C.] UPF, Barcelona, Spain. [Turner, Michelle C.] CIBERESP, Barcelona, Spain. [Jerrett, Michael] Univ Calif Los Angeles, Dept Environm Hlth Sci, Los Angeles, CA USA. [Pope, C. Arden, III] Brigham Young Univ, Dept Econ, Provo, UT 84602 USA. [Hubbell, Bryan; Fann, Neal] US EPA, Durham, NC USA. [Cohen, Aaron] Hlth Effects Inst, Boston, MA USA. [Gapstur, Susan M.; Diver, W. Ryan] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA. [Forouzanfar, Mohammad H.] Inst Hlth Metr & Evaluat, Seattle, WA USA. [Kim, Sun-Young] Seoul Natl Univ, Inst Hlth & Environm, Seoul, South Korea. [Olives, Casey] Univ Washington, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USA. RP Szyszkowicz, M (reprint author), Hlth Canada, Environm Hlth Sci & Res Bur, 200 Eglantine Driveway, Ottawa, ON K1A 0K9, Canada. EM mietek.szyszkowicz@hc-sc.gc.ca OI Hubbell, Bryan/0000-0002-7963-3438 FU Government of Canada Banting Postdoctoral Fellowship FX MCT was funded by a Government of Canada Banting Postdoctoral Fellowship. NR 35 TC 0 Z9 0 U1 13 U2 13 PU SPRINGER INTERNATIONAL PUBLISHING AG PI CHAM PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND SN 1873-9318 EI 1873-9326 J9 AIR QUAL ATMOS HLTH JI Air Qual. Atmos. Health PD DEC PY 2016 VL 9 IS 8 BP 961 EP 972 DI 10.1007/s11869-016-0398-z PG 12 WC Environmental Sciences SC Environmental Sciences & Ecology GA EB4IH UT WOS:000387334000012 PM 27867428 ER PT J AU Smith, ME Stark, BL Chuang, WC Dennehy, TJ Harlan, SL Kamp-Whittaker, A Stanley, BW York, AM AF Smith, Michael E. Stark, Barbara L. Chuang, Wen-Ching Dennehy, Timothy J. Harlan, Sharon L. Kamp-Whittaker, April Stanley, Benjamin W. York, Abigail M. TI Comparative Methods for Premodern Cities: Coding for Governance and Class Mobility SO CROSS-CULTURAL RESEARCH LA English DT Article DE urban history; class mobility; governance; coding; premodern ID EVOLUTION; EQUITY AB We describe methods of coding and analyzing historical and archaeological data for comparative analysis of premodern cities. As part of a larger study of spatial access to urban services, we identify eight relevant contextual domains and define variables for each domain. Information from publications on each city is assembled, and the data are coded independently by three scholars and checked for agreement. To date, we have completed contextual coding for 15 cities. Here, we focus on methods to analyze relationships among variables within contextual domains using two example domainsClass Mobility and Governance. Key methodological points involve the problem of missing data, multiple tests with an appropriate correction, and the importance of variation among cases for effective analysis of a domain. Our interpretation of preliminary findings highlights a degree of independence between two different arenas of social life that may relate to collective action. Documentation of our procedures contributes to a growing body of systematic, comparative, cross-cultural analyses of mid-size samples. This study is distinctive in its focus on cities rather than cultures, societies, or polities. C1 [Smith, Michael E.; York, Abigail M.] Arizona State Univ, Archaeol, Sch Human Evolut & Social Change, Tempe, AZ 85287 USA. [Stark, Barbara L.; Dennehy, Timothy J.; Kamp-Whittaker, April; Stanley, Benjamin W.] Arizona State Univ, Tempe, AZ 85287 USA. [Chuang, Wen-Ching] Arizona State Univ, Sch Human Evolut & Social Change, 900 S Cady Mall,POB 872402, Tempe, AZ 85287 USA. [York, Abigail M.] Arizona State Univ, Sch Human Evolut & Social Change, Governance & Publ Policy, Tempe, AZ 85287 USA. [Harlan, Sharon L.] Northeastern Univ, Sociol & Hlth Sci, Boston, MA 02115 USA. [Chuang, Wen-Ching] CNR, Cincinnati, OH USA. [Chuang, Wen-Ching] US EPA, Cincinnati, OH 45268 USA. RP Smith, ME (reprint author), Arizona State Univ, Sch Human Evolut & Social Change, 900 S Cady Mall,POB 872402, Tempe, AZ 85287 USA. EM mesmith9@asu.edu FU National Science Foundation [1260344]; School of Human Evolution and Social Change at Arizona State University; President's Strategic Fund at Arizona State University FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Funding for the project "Service Access in Premodern Cities" is provided by the National Science Foundation, Grant 1260344, and by the School of Human Evolution and Social Change at Arizona State University. The initial stage of the project was funded by the President's Strategic Fund at Arizona State University. NR 48 TC 0 Z9 0 U1 4 U2 4 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1069-3971 EI 1552-3578 J9 CROSS-CULT RES JI Cross-Cult. Res. PD DEC PY 2016 VL 50 IS 5 BP 415 EP 451 DI 10.1177/1069397116665824 PG 37 WC Social Sciences, Interdisciplinary SC Social Sciences - Other Topics GA EB4CO UT WOS:000387317100002 ER PT J AU Pleil, JD AF Pleil, Joachim D. TI Imputing defensible values for left-censored 'below level of quantitation' (LoQ) biomarker measurements SO JOURNAL OF BREATH RESEARCH LA English DT Article DE biomarkers; data models; below detection; below quantitation; left-censored; imputed values ID PERSPECTIVE; BREATH; BLOOD AB Biomarker datasets often include entries 'below the level of quantitation' (LoQ) wherein the instrumentation is no longer able to provide values that meet required analytical quality standards, a phenomenon referred to as 'left-censored' data. Generally, some form of imputation for missing values is required to allow calculating distributions and summary statistics for comparing datasets to each other. This article discusses the available options for imputing (modeling) left-censored data, presents the methods for implementing different procedures, and provides examples and guidelines using realistic data to assess relative performance. Ultimately, multiple ordered value imputation is identified as the best method; therein, the overall distribution of actual measures is used in conjunction with an estimate of relative order of the missing values to provide the most likely estimates below the LoQ. C1 [Pleil, Joachim D.] US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. RP Pleil, JD (reprint author), US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. NR 27 TC 0 Z9 0 U1 1 U2 1 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 1752-7155 EI 1752-7163 J9 J BREATH RES JI J. Breath Res. PD DEC PY 2016 VL 10 IS 4 AR 045001 DI 10.1088/1752-7155/10/4/045001 PG 11 WC Biochemical Research Methods; Respiratory System SC Biochemistry & Molecular Biology; Respiratory System GA EA4YG UT WOS:000386622300001 PM 27491525 ER PT J AU Saunders, JA Pivetz, BE Voorhies, N Wilkin, RT AF Saunders, James A. Pivetz, Bruce E. Voorhies, Nathan Wilkin, Richard T. TI Potential aquifer vulnerability in regions down-gradient from uranium in situ recovery (ISR) sites SO JOURNAL OF ENVIRONMENTAL MANAGEMENT LA English DT Review DE Uranium fate and transport; Roll-front deposits; In situ leaching; Trace metal mobilization; Uranium geochemistry; Hydrogeology; Groundwater monitoring ID SULFATE-REDUCING BACTERIA; EMULSIFIED VEGETABLE-OIL; CONTAMINATED AQUIFER; AQUEOUS-SOLUTIONS; ELECTRON-DONOR; ORE-DEPOSITS; NW CHINA; REDUCTION; GROUNDWATER; SORPTION AB Sandstone-hosted roll-front uranium ore deposits originate when U(VI) dissolved in groundwater is reduced and precipitated as insoluble U(IV) minerals. Groundwater redox geochemistry, aqueous complexation, and solute migration are important in leaching uranium from source rocks and transporting it in low concentrations to a chemical redox interface where it is deposited in an ore zone typically containing the uranium minerals uraninite, pitchblende, and/or coffinite; various iron sulfides; native selenium; clays; and calcite. In situ recovery (ISR) of uranium ores is a process of contacting the uranium mineral deposit with leaching and oxidizing (lixiviant) fluids via injection of the lixiviant into wells drilled into the subsurface aquifer that hosts uranium ore, while other extraction wells pump the dissolved uranium after dissolution of the uranium minerals. Environmental concerns during and after ISR include water quality degradation from: 1) potential excursions of leaching solutions away from the injection zone into down-gradient, underlying, or overlying aquifers; 2) potential migration of uranium and its decay products (e.g., Ra, Rn, Pb); and, 3) potential mobilization and migration of redox-sensitive trace metals (e.g., Fe, Mn, Mo, Se, V), metalloids (e.g., As), and anions (e.g., sulfate). This review describes the geochemical processes that control roll-front uranium transport and fate in groundwater systems, identifies potential aquifer vulnerabilities to ISR operations, identifies data gaps in mitigating these vulnerabilities, and discusses the hydrogeological characterization involved in developing a monitoring program. Published by Elsevier Ltd. C1 [Saunders, James A.] Auburn Univ, Dept Geosci, 210 Petrie Hall, Auburn, AL 36849 USA. [Pivetz, Bruce E.] CSS Dynamac, 10301 Democracy Lane Suite 300, Fairfax, VA 22030 USA. [Voorhies, Nathan] Battelle Mem Inst, Environm Solut & Serv, 1300 Clay St,Suite 600, Oakland, CA 94612 USA. [Wilkin, Richard T.] US EPA, Natl Risk Management Res Lab, Ground Water & Ecosyst Restorat Div, 919 Kerr Res Dr, Ada, OK 74820 USA. RP Wilkin, RT (reprint author), US EPA, Natl Risk Management Res Lab, Ground Water & Ecosyst Restorat Div, 919 Kerr Res Dr, Ada, OK 74820 USA. EM wilkin.rick@epa.gov NR 144 TC 0 Z9 0 U1 23 U2 24 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0301-4797 EI 1095-8630 J9 J ENVIRON MANAGE JI J. Environ. Manage. PD DEC 1 PY 2016 VL 183 BP 67 EP 83 DI 10.1016/j.jenvman.2016.08.049 PN 1 PG 17 WC Environmental Sciences SC Environmental Sciences & Ecology GA EA2IE UT WOS:000386415200007 PM 27576149 ER PT J AU Rauglas, E Martin, S Bailey, K Magnuson, M Phillips, R Harper, WF AF Rauglas, Erik Martin, Seth Bailey, Kandace Magnuson, Matthew Phillips, Rebecca Harper, Willie F., Jr. TI The effect of malathion on the activity, performance, and microbial ecology of activated sludge SO JOURNAL OF ENVIRONMENTAL MANAGEMENT LA English DT Article DE Activated sludge; Respiration; Inhibition; Malathion; Ecology ID GEN. NOV.; BIODEGRADATION; PESTICIDES; DIVERSITY; TOXICITY; FATE AB This study evaluated the effect of a VX (0-ethyl S-[2-(diisopropylamino)ethyl] methylphosphonothioate) surrogate (malathion) on the activity, performance, and ecology of activated sludge bioreactors. In the presence of malathion, the maximum observed respiration rates varied between 43 and 53 mu g/O-2 min, generally similar to the 49 mu g O-2/min rates observed in controls. Malathion did not alter the respiration ratio of O-2 consumed-to-CO2 produced nor did it impact the shape of the oxygen,consumption curves during respirometry. Shorter term (12 h) batch tests showed that both chemical oxygen demand (COD) and ammonia removal were not negatively impacted by the presence of 0.1-3 mg/L malathion. Longer term continuous addition (i.e. 40 days) of 0.1 mg/L of malathion also had no effect on COD and ammonia removal. In contrast to shorter term exposures, longer term continuous addition of 3 mg/L of malathion negatively impacted both COD and nitrogen removal and was associated with shifts in the abundance of species that are common to activated sludge. These results illustrate the impact that chemicals like malathion may have on COD removal, and nitrification, as well as the robustness of activated sludge microbial communities. Published by Elsevier Ltd. C1 [Rauglas, Erik; Martin, Seth; Harper, Willie F., Jr.] Air Force Inst Technol, Dept Syst Engn & Management, 2950 Hobson Way, Wright Patterson AFB, OH 45433 USA. [Bailey, Kandace] Air Force Inst Technol, Oak Ridge Inst Sci & Educ Program, Dept Syst Engn & Management, 2950 Hobson Way, Wright Patterson AFB, OH 45433 USA. [Magnuson, Matthew] US EPA, Natl Homeland Secur Res Ctr, Water Infrastruct Protect Div, 26 W Martin Luther King Dr,Mailstop NG 16, Cincinnati, OH 45268 USA. [Phillips, Rebecca] US EPA, Oak Ridge Inst Sci & Educ Program, 1300 Penn Ave NW,ML 8801 RR, Washington, DC 20011 USA. RP Harper, WF (reprint author), Air Force Inst Technol, Dept Syst Engn & Management, 2950 Hobson Way, Wright Patterson AFB, OH 45433 USA. EM willie.harper@afit.edu NR 34 TC 0 Z9 0 U1 8 U2 8 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0301-4797 EI 1095-8630 J9 J ENVIRON MANAGE JI J. Environ. Manage. PD DEC 1 PY 2016 VL 183 BP 220 EP 228 DI 10.1016/j.jenvman.2016.08.076 PN 1 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA EA2IE UT WOS:000386415200023 PM 27594690 ER PT J AU Hou, WC Henderson, WM Chowdhury, I Goodwin, DG Chang, XJ Martin, S Fairbrother, DH Bouchard, D Zepp, RG AF Hou, Wen-Che Henderson, W. Matthew Chowdhury, Indranil Goodwin, David G., Jr. Chang, Xiaojun Martin, Sharon Fairbrother, D. Howard Bouchard, Dermont Zepp, Richard G. TI The contribution of indirect photolysis to the degradation of graphene oxide in sunlight SO CARBON LA English DT Article ID DISSOLVED ORGANIC-MATTER; SOUTHEASTERN UNITED-STATES; MULTIWALLED CARBON NANOTUBES; AQUEOUS C-60 CLUSTERS; CENTER-DOT-OH; QUANTUM DOTS; PHOTOCHEMICAL TRANSFORMATION; FENTON REACTION; HYDROXYL RADICALS; SURFACE OXIDES AB This paper probes the role of hydroxyl radicals (center dot OH) generated by H2O2 photolysis on graphene oxide (GO) phototransformation, under simulated sunlight. It focuses on comparing the photoreaction of GO with (indirect) and without (direct) added H2O2 under simulated sunlight conditions. The biomarker responses of fish epithelial cells in in vitro assays of parent GO and GO photoreacted with H2O2 and their interaction with model biomembranes are also compared. GO was found to be far more extensively photodecomposed in the presence of H2O2, with similar to 85% of the initial carbon content converted to CO2 during 48 h of irradiation. Direct and indirect photoreactions occurred concurrently in GO samples containing H2O2, and indirect photoreaction accounted for similar to 70% of GO conversion to CO2. Reaction with center dot OH causes increases in the concentrations of carboxylic acid groups of photoreacted GO and low molecular-weight (LMW) species as part of the intermediate photoproducts. Compared to parent GO, intermediate photoproducts exhibited reduced interaction with model cell membranes and altered biomarker responses. Kinetic analysis extrapolating our data to conditions prevalent in sunlit surface waters predicts that initial GO photoreaction is dominated by direct photolysis, while indirect photo reactions involving center dot OH determine subsequent conversion of intermediate GO photoproducts to CO2. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Hou, Wen-Che] Natl Cheng Kung Univ, Dept Environm Engn, Tainan 70101, Taiwan. [Chowdhury, Indranil] Washington State Univ, Dept Civil & Environm Engn, Pullman, WA 99164 USA. [Henderson, W. Matthew; Chang, Xiaojun; Bouchard, Dermont; Zepp, Richard G.] US EPA, Natl Exposure Res Lab, Exposure Methods & Measurement Div, Athens, GA 30605 USA. [Goodwin, David G., Jr.; Fairbrother, D. Howard] Johns Hopkins Univ, Dept Chem, Charles & 34Th St, Baltimore, MD 21218 USA. [Martin, Sharon] US EPA, Via Oak Ridge Inst Sci & Educ, Athens, GA 30605 USA. RP Hou, WC (reprint author), Natl Cheng Kung Univ, Dept Environm Engn, Tainan 70101, Taiwan.; Chowdhury, I (reprint author), Washington State Univ, Dept Civil & Environm Engn, Pullman, WA 99164 USA.; Zepp, RG (reprint author), US EPA, Natl Exposure Res Lab, Exposure Methods & Measurement Div, Athens, GA 30605 USA. EM whou@mail.ncku.edu.tw; indranil.chowdhury@wsu.edu; zepp.richard@epa.gov RI Hou, Wen-Che/F-5736-2011 OI Hou, Wen-Che/0000-0001-9884-2932 FU Ministry of Science and Technology (MOST) of Taiwan [MOST 103-2221-E-006-015-MY3]; U.S. EPA [R834858]; Owens Fellowship at JHU FX This paper has been reviewed in accordance with the U.S. Environmental Protection Agency's (U. S. EPA) peer and administrative review policies and approved for publication. Mention of trade names or commercial products does not constitute an endorsement or recommendation for use by the U.S. EPA. Financial support provided by the Ministry of Science and Technology (MOST) of Taiwan (for Hou) under grant number MOST 103-2221-E-006-015-MY3 is acknowledged. D.H.F. acknowledges financial support by the U.S. EPA under grant R834858. Goodwin acknowledges the Owens Fellowship at JHU for financial support. NR 67 TC 1 Z9 1 U1 29 U2 29 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0008-6223 EI 1873-3891 J9 CARBON JI Carbon PD DEC PY 2016 VL 110 BP 426 EP 437 DI 10.1016/j.carbon.2016.09.013 PG 12 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA EA2DJ UT WOS:000386402700049 ER PT J AU Birge, HE Allen, CR Garmestani, AS Pope, KL AF Birge, Hannah E. Allen, Craig R. Garmestani, Ahjond S. Pope, Kevin L. TI Adaptive management for ecosystem services SO JOURNAL OF ENVIRONMENTAL MANAGEMENT LA English DT Article DE Complex systems; Scale; Social-ecological systems; Structured decision making; Sustainability; Uncertainty ID PROTECTED AREA; BIODIVERSITY; RESILIENCE; SCALE; CLASSIFICATION; CONSERVATION; ENVIRONMENT; LANDSCAPES; PHOSPHORUS; VALUATION AB Management of natural resources for the production of ecosystem services, which are vital for human well-being, is necessary even when there is uncertainty regarding system response to management action. This uncertainty is the result of incomplete controllability, complex internal feedbacks, and non linearity that often interferes with desired management outcomes, and insufficient understanding of nature and people. Adaptive management was developed to reduce such uncertainty. We present a framework for the application of adaptive management for ecosystem services that explicitly accounts for cross-scale tradeoffs in the production of ecosystem services. Our framework focuses on identifying key spatiotemporal scales (plot, patch, ecosystem, landscape, and region) that encompass dominant structures and processes in the system, and includes within- and cross-scale dynamics, ecosystem service tradeoffs, and management controllability within and across scales. Resilience theory recognizes that a limited set of ecological processes in a given system regulate ecosystem services, yet our understanding of these processes is poorly understood. If management actions erode or remove these processes, the system may shift into an alternative state unlikely to support the production of desired services. Adaptive management provides a process to assess the underlying within and cross-scale tradeoffs associated with production of ecosystem services while proceeding with management designed to meet the demands of a growing human population. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Birge, Hannah E.] Univ Nebraska, Nebraska Cooperat Fish & Wildlife Res Unit, Lincoln, NE 68583 USA. [Birge, Hannah E.; Allen, Craig R.; Pope, Kevin L.] Univ Nebraska, Sch Nat Resources, Lincoln, NE 68583 USA. [Allen, Craig R.; Pope, Kevin L.] Univ Nebraska, US Geol Survey, Nebraska Cooperat Fish & Wildlife Res Unit, Lincoln, NE 68583 USA. [Garmestani, Ahjond S.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Birge, HE (reprint author), Univ Nebraska, Nebraska Cooperat Fish & Wildlife Res Unit, Lincoln, NE 68583 USA.; Birge, HE (reprint author), Univ Nebraska, Sch Nat Resources, Lincoln, NE 68583 USA. EM hannah.birge@huskers.unl.edu; allencr@unl.edu; garmestani.ahjond@epa.gov; kpope2@unl.edu FU U.S. Geological Survey; Nebraska Game and Parks Commission; University of Nebraska Lincoln; U.S. Fish and Wildlife Service; Wildlife Management Institute FX We thank the authors of the papers in this special issue on adaptive management for ecosystem services for their diligent efforts and timely submissions. The final manuscript was greatly improved by comments from Dr. Anil Giri, Dr. Berrin Tansel, and two anonymous reviewers. The views expressed in this paper are those of the authors and do not necessarily represent the views or policies of the U.S. Environmental Protection Agency. The Nebraska Cooperative Fish and Wildlife Research Unit is jointly supported by a cooperative agreement between the U.S. Geological Survey, the Nebraska Game and Parks Commission, the University of Nebraska Lincoln, the U.S. Fish and Wildlife Service and the Wildlife Management Institute. NR 87 TC 0 Z9 0 U1 57 U2 57 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0301-4797 EI 1095-8630 J9 J ENVIRON MANAGE JI J. Environ. Manage. PD DEC 1 PY 2016 VL 183 BP 343 EP 352 DI 10.1016/j.jenvman.2016.07.054 PN 2 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA EA2HV UT WOS:000386414300001 PM 27460215 ER PT J AU Gunderson, LH Cosens, B Garmestani, AS AF Gunderson, Lance H. Cosens, Barbara Garmestani, Ahjond S. TI Adaptive governance of riverine and wetland ecosystem goods and services SO JOURNAL OF ENVIRONMENTAL MANAGEMENT LA English DT Article DE Adaptive governance; Resilience; Ecosystem services; Adaptive management ID SOCIAL-ECOLOGICAL SYSTEMS; WATER MANAGEMENT; RESILIENCE; SHIFTS; EVERGLADES; REEF AB Adaptive governance and adaptive management have developed over the past quarter century in response to institutional and organizational failures, and unforeseen changes in natural resource dynamics. Adaptive governance provides a context for managing known and unknown consequences of prior management approaches and for increasing legitimacy in the implementation of flexible and adaptive management. Using examples from iconic water systems in the United States, we explore the proposition that adaptive management and adaptive governance are useful for evaluating the complexities of trade-offs among ecosystem goods and services. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Gunderson, Lance H.] Emory Univ, Dept Environm Sci, Atlanta, GA 30322 USA. [Cosens, Barbara] Univ Idaho, Waters West Program, Coll Law, Moscow, ID 83844 USA. [Garmestani, Ahjond S.] US EPA, Cincinnati, OH 45268 USA. RP Gunderson, LH (reprint author), Emory Univ, Dept Environm Sci, Atlanta, GA 30322 USA. EM lgunder@emory.edu; bcosens@uidaho.edu; garmestani.ahjond@epa.gov FU National Socio-Environmental Synthesis Center (SESYNC) under National Science Foundation [DBI-1052875] FX Many of the ideas in this article were supported in part by a collaboration grant the National Socio-Environmental Synthesis Center (SESYNC) under funding from the National Science Foundation DBI-1052875. The views expressed in this paper are those of the authors and do not represent the views or policies of the U.S. Environmental Protection Agency. NR 61 TC 3 Z9 3 U1 18 U2 18 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0301-4797 EI 1095-8630 J9 J ENVIRON MANAGE JI J. Environ. Manage. PD DEC 1 PY 2016 VL 183 BP 353 EP 360 DI 10.1016/j.jenvman.2016.05.024 PN 2 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA EA2HV UT WOS:000386414300002 PM 27206806 ER PT J AU Chaffin, BC Garmestani, AS Angeler, DG Herrmann, DL Stow, CA Nystrom, M Sendzimir, J Hopton, ME Kolasa, J Allen, CR AF Chaffin, Brian C. Garmestani, Ahjond S. Angeler, David G. Herrmann, Dustin L. Stow, Craig A. Nystrom, Magnus Sendzimir, Jan Hopton, Matthew E. Kolasa, Jurek Allen, Craig R. TI Biological invasions, ecological resilience and adaptive governance SO JOURNAL OF ENVIRONMENTAL MANAGEMENT LA English DT Article DE Biological invasions; Invasive species; Ecological resilience; Adaptive governance; Adaptive management; Ecosystem services ID BODY-MASS DISTRIBUTIONS; ECOSYSTEM SERVICES; EVERGLADES ECOSYSTEM; COMMUNITY DYNAMICS; TALLGRASS PRAIRIE; CORAL-REEFS; MANAGEMENT; EXTINCTIONS; SYSTEMS; BIODIVERSITY AB In a world of increasing interconnections in global trade as well as rapid change in climate and land cover, the accelerating introduction and spread of invasive species is a critical concern due to associated negative social and ecological impacts, both real and perceived. Much of the societal response to invasive species to date has been associated with negative economic consequences of invasions. This response has shaped a war-like approach to addressing invasions, one with an agenda of eradications and intense ecological restoration efforts towards prior or more desirable ecological regimes. This trajectory often ignores the concept of ecological resilience and associated approaches of resilience-based governance. We argue that the relationship between ecological resilience and invasive species has been understudied to the detriment of attempts to govern invasions, and that most management actions fail, primarily because they do not incorporate adaptive, learning-based approaches. Invasive species can decrease resilience by reducing the biodiversity that underpins ecological functions and processes, making ecosystems more prone to regime shifts. However, invasions do not always result in a shift to an alternative regime; invasions can also increase resilience by introducing novelty, replacing lost ecological functions or adding redundancy that strengthens already existing structures and processes in an ecosystem. This paper examines the potential impacts of species invasions on the resilience of ecosystems and suggests that resilience-based approaches can inform policy by linking the governance of biological invasions to the negotiation of tradeoffs between ecosystem services. (C) 2016 Published by Elsevier Ltd. C1 [Chaffin, Brian C.] Univ Montana, Coll Forestry & Conservat, Dept Soc & Conservat, 32 Campus Dr, Missoula, MT 59812 USA. [Garmestani, Ahjond S.; Hopton, Matthew E.] US EPA, Natl Risk Management Res Lab, 26 W Martin Luther King Jr Dr, Cincinnati, OH 45268 USA. [Angeler, David G.] Swedish Univ Agr Sci, Dept Aquat Sci & Assessment, Box 7050, S-75007 Uppsala, Sweden. [Herrmann, Dustin L.] US EPA, Oak Ridge Inst Sci, 26 W Martin Luther King Jr Dr, Cincinnati, OH 45268 USA. [Herrmann, Dustin L.] US EPA, Educ Res Participant Program, 26 W Martin Luther King Jr Dr, Cincinnati, OH 45268 USA. [Stow, Craig A.] NOAA, Great Lakes Environm Res Lab, 4840 S State Rd, Ann Arbor, MI 48108 USA. [Nystrom, Magnus] Stockholm Univ, Stockholm Resilience Ctr, Kraftriket 2B, SE-10691 Stockholm, Sweden. [Sendzimir, Jan] Univ Nat Resources & Appl Life Sci BOKU, Inst Hydrobiol & Aquat Ecosyst Management, Max Emanuel Str 17, A-1180 Vienna, Austria. [Kolasa, Jurek] McMaster Univ, Dept Biol, 1280 Main St West, Hamilton, ON L8S 4K1, Canada. [Allen, Craig R.] Univ Nebraska, US Geol Survey, Nebraska Cooperat Fish & Wildlife Unit, 423 Hardin Hall,3310 Holdrege St, Lincoln, NE 68583 USA. RP Chaffin, BC (reprint author), Univ Montana, Coll Forestry & Conservat, Dept Soc & Conservat, 32 Campus Dr, Missoula, MT 59812 USA. EM brian.chaffin@umontana.edu; garmestani.ahjond@epa.gov; david.angeler@slu.se; herrmann.dustin@epa.gov; craig.stow@noaa.gov; magnus.nystrom@su.se; jan.sendzimir@boku.ac.at; hopton.matthew@epa.gov; kolasa@mcmaster.ca; callen3@unl.edu OI Hopton, Matt/0000-0001-7962-6820 FU U.S. Geological Survey; Nebraska Game and Parks Commission; University of Nebraska-Lincoln; U.S. Fish and Wildlife Service; Wildlife Management Institute; August T. Larsson Foundation of the Swedish University of Agricultural Sciences; U.S. Geological Survey John Wesley Powell Center for Analysis and Synthesis; Great Lakes Environmental Research Laboratory [1817]; Swedish Research Councils Formas [2014-1193]; Vetenskapsradet [2014-5828] FX The Nebraska Cooperative Fish and Wildlife Research Unit is jointly supported by a cooperative agreement between the U.S. Geological Survey, the Nebraska Game and Parks Commission, the University of Nebraska-Lincoln, the U.S. Fish and Wildlife Service and the Wildlife Management Institute. This research was partially conducted with the support of two appointments to the Research Participation Program at the U.S. Environmental Protection Agency National Risk Management Research Laboratory, one administered by the National Academies Research Associateship Program, and one by the Oak Ridge Institute for Science and Education. The views expressed herein are those of the authors and do not necessarily represent those of the U.S. Environmental Protection Agency. We gratefully acknowledge funding from the August T. Larsson Foundation of the Swedish University of Agricultural Sciences, the U.S. Geological Survey John Wesley Powell Center for Analysis and Synthesis, the Great Lakes Environmental Research Laboratory (contribution number 1817) and the Swedish Research Councils Formas (2014-1193) and Vetenskapsradet (2014-5828). NR 90 TC 1 Z9 1 U1 78 U2 78 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0301-4797 EI 1095-8630 J9 J ENVIRON MANAGE JI J. Environ. Manage. PD DEC 1 PY 2016 VL 183 BP 399 EP 407 DI 10.1016/j.jenvman.2016.04.040 PN 2 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA EA2HV UT WOS:000386414300007 PM 27377866 ER PT J AU Chaffin, BC Shuster, WD Garmestani, AS Furio, B Albro, SL Gardiner, M Spring, M Green, OO AF Chaffin, Brian C. Shuster, William D. Garmestani, Ahjond S. Furio, Brooke Albro, Sandra L. Gardiner, Mary Spring, MaLisa Green, Olivia Odom TI A tale of two rain gardens: Barriers and bridges to adaptive management of urban stormwater in Cleveland, Ohio SO JOURNAL OF ENVIRONMENTAL MANAGEMENT LA English DT Article DE Adaptive management; Cleveland; Ohio USA; Green infrastructure; Stormwater; Rain gardens; Urban sewersheds ID ECOSYSTEM SERVICES; OVERFLOWS; IMPACT AB Green infrastructure installations such as rain gardens and bioswales are increasingly regarded as viable tools to mitigate stormwater runoff at the parcel level. The use of adaptive management to implement and monitor green infrastructure projects as experimental attempts to manage stormwater has not been adequately explored as a way to optimize green infrastructure performance or increase social and political acceptance. Efforts to improve stormwater management through green infrastructure suffer from the complexity of overlapping jurisdictional boundaries, as well as interacting social and political forces that dictate the flow, consumption, conservation and disposal of urban wastewater flows. Within this urban milieu, adaptive management rigorous experimentation applied as policy can inform new wastewater management techniques such as the implementation of green infrastructure projects. In this article, we present a narrative of scientists and practitioners working together to apply an adaptive management approach to green infrastructure implementation for stormwater management in Cleveland, Ohio. In Cleveland, contextual legal requirements and environmental factors created an opportunity for government researchers, stormwater managers and community organizers to engage in the development of two distinct sets of rain gardens, each borne of unique social, economic and environmental processes. In this article we analyze social and political barriers to applying adaptive management as a framework for implementing green infrastructure experiments as policy. We conclude with a series of lessons learned and a reflection on the prospects for adaptive management to facilitate green infrastructure implementation for improved stormwater management. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Chaffin, Brian C.] Univ Montana, Dept Soc & Conservat, Coll Forestry & Conservat, 32 Campus Dr, Missoula, MT 59812 USA. [Shuster, William D.; Garmestani, Ahjond S.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, 26 Martin Luther King Jr Dr, Cincinnati, OH 45268 USA. [Furio, Brooke] US EPA, Off Enforcement & Compliance Assurance, Reg 5,25063 Ctr Ridge Rd, Westlake, OH 44145 USA. [Albro, Sandra L.] Cleveland Bot Garden, 11030 East Blvd, Cleveland, OH 44106 USA. [Gardiner, Mary; Spring, MaLisa] Ohio State Univ, Coll Food Agr & Environm Sci, Dept Entomol, 1680 Madison Ave, Wooster, OH 44691 USA. [Green, Olivia Odom] Atlantic States Legal Fdn, 658 W Onondaga St, Syracuse, NY 13204 USA. RP Chaffin, BC (reprint author), Univ Montana, Dept Soc & Conservat, Coll Forestry & Conservat, 32 Campus Dr, Missoula, MT 59812 USA. EM brian.chaffin@umontana.edu; shuster.william@epa.gov; garmestani.ahjond@epa.gov; furio.brooke@epa.gov; salbro@cbgarden.org; gardiner.29@osu.edu; malisa.spring@gmail.com; ogreen@aslf.org FU U.S. EPA Urban Waters Program [UW-00E01022]; Louise H. and David S. Ingalls Foundation; Sears-Swetland Family Foundation; Northeast Ohio Regional Sewer District FX The views expressed in this paper are those of the authors and do not represent the views or policies of the U.S. Environmental Protection Agency (EPA). This research was conducted with the support of two postdoctoral appointments to the Research Participation Program at the National Risk Management Research Laboratory, one administered by the Oak Ridge Institute for Science and Education and one administered by the National Research Council, Research Associateship Program. We would like to acknowledge the invaluable contributions of the Slavic Village Development Corporation (Marlane Weslian, Marie Kitteridge, Stacia Pugh), the Northeast Ohio Regional Sewer District and the U.S. Geological Survey (Rob Darner) in making this research project possible. Project implementation was funded through grants to the Cleveland Botanical Garden from the U.S. EPA Urban Waters Program (#UW-00E01022), the The Louise H. and David S. Ingalls Foundation, The Sears-Swetland Family Foundation and the Northeast Ohio Regional Sewer District. We thank Katelyn Gilkey for her support with graphics in the manuscript. NR 45 TC 1 Z9 1 U1 39 U2 39 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0301-4797 EI 1095-8630 J9 J ENVIRON MANAGE JI J. Environ. Manage. PD DEC 1 PY 2016 VL 183 BP 431 EP 441 DI 10.1016/j.jenvman.2016.06.025 PN 2 PG 11 WC Environmental Sciences SC Environmental Sciences & Ecology GA EA2HV UT WOS:000386414300011 PM 27372737 ER PT J AU Ladd, MA Fitzsimmons, PN Nichols, JW AF Ladd, Melanie A. Fitzsimmons, Patrick N. Nichols, John W. TI Optimization of a UDP-glucuronosyltransferase assay for trout liver S9 fractions: activity enhancement by alamethicin, a pore-forming peptide SO XENOBIOTICA LA English DT Article DE Alamethicin; glucuronidation; liver S9 fraction; rainbow trout; UDP-glucuronosyltransferase; UGT ID VITRO INTRINSIC CLEARANCE; PLASMA STEROID-LEVELS; RAINBOW-TROUT; ONCORHYNCHUS-MYKISS; IN-VIVO; ENZYME-ACTIVITIES; ORGANIC-SOLVENTS; SALMO-GAIRDNERI; MEASURED RATES; GLUCURONIDATION AB 1. An existing assay for UDP-glucuronosyltransferase (UGT) activity in trout liver microsomes was optimized using trout liver S9 fractions. Individual experiments were conducted to determine the time dependence of UGT activity as well as optimal levels of S9 protein, uridine 5'-diphosphoglucuronic acid (UDPGA), substrate (p-nitrophenol) and alamethicin, a pore-forming agent added to eliminate latency. 2. Addition of Mg2+(to 1mM) or bovine serum albumin (BSA; to 2% w/v) had variable effects on activity, but these effects were minor. Eliminating alamethicin from the system resulted in very low levels of activity. A portion of this activity could be recovered by adding Triton X-100 or Brij 58; however, the optimal concentration range for either detergent was very narrow. 3. When expressed on a pmol/min/g liver basis, UGT activities determined using this updated assay were substantially higher than those reported previously for uninduced trout. 4. These results clearly demonstrate the advantages of using alamethicin for the removal of latency in UGT activity studies with trout and may have broad implications for the study of UGTs in other fish species. C1 [Ladd, Melanie A.; Fitzsimmons, Patrick N.; Nichols, John W.] US EPA, ORD, NHEERL, Midcontinent Ecol Div, Duluth, MN USA. RP Nichols, JW (reprint author), US EPA, Midcontinent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA. EM nichols.john@epa.gov NR 52 TC 1 Z9 1 U1 4 U2 4 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 0049-8254 EI 1366-5928 J9 XENOBIOTICA JI Xenobiotica PD DEC PY 2016 VL 46 IS 12 BP 1066 EP 1075 DI 10.3109/00498254.2016.1149634 PG 10 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA DZ2UP UT WOS:000385697400003 PM 26947351 ER PT J AU Ding, WJ Ghio, AJ Wu, WD AF Ding, Wenjun Ghio, Andrew J. Wu, Weidong TI Preface: Special Issue on Air Pollution SO BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS LA English DT Editorial Material C1 [Ding, Wenjun] Univ Chines Acad Sci, Coll Life Sci, Lab Environm & Hlth, Beijing, Peoples R China. [Ghio, Andrew J.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Wu, Weidong] Xinxiang Med Univ, Sch Publ Hlth, Xinxiang 453003, Henan Province, Peoples R China. RP Ghio, AJ (reprint author), Human Studies Facil, Campus Box 7315,104 Mason Farm Rd, Chapel Hill, NC 27599 USA. EM dingwj@gucas.ac.cn; ghio.andy@epa.gov NR 13 TC 0 Z9 0 U1 22 U2 22 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-4165 EI 1872-8006 J9 BBA-GEN SUBJECTS JI Biochim. Biophys. Acta-Gen. Subj. PD DEC PY 2016 VL 1860 IS 12 SI SI BP 2769 EP 2770 DI 10.1016/j.bbagen.2016.09.007 PG 2 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA DY1PK UT WOS:000384866700001 PM 27640311 ER PT J AU Ghio, AJ Soukup, JM Dailey, LA AF Ghio, Andrew J. Soukup, Joleen M. Dailey, Lisa A. TI Air pollution particles and iron homeostasis SO BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS LA English DT Review DE Air pollution; Iron; Inflammation; Oxidants; Oxidative stress; Kinases; Transcription factors ID HUMIC-LIKE SUBSTANCES; SIGNAL-REGULATED KINASE; OXIDATIVE STRESS; EPITHELIAL-CELLS; IN-VITRO; PARTICULATE MATTER; MITOCHONDRIAL IRON; MOLECULAR CONTROL; LUNG-TISSUE; RAT-LIVER AB Background: The mechanism underlying biological effects, including pro-inflammatory outcomes, of particles deposited in the lung has not been defined. Major conclusions: A disruption in iron homeostasis follows exposure of cells to all particulate matter including air pollution particles. Following endocytosis, functional groups at the surface of retained particle complex iron available in the cell. In response to a reduction in concentrations of requisite iron, a functional deficiency can result intracellularly. Superoxide production by the cell exposed to a particle increases ferrireduction which facilitates import of iron with the objective being the reversal of the metal deficiency. Failure to resolve the functional iron deficiency following cell exposure to particles activates kinases and transcription factors resulting in a release of inflammatory mediators and inflammation. Tissue injury is the end product of this disruption in iron homeostasis initiated by the particle exposure. Elevation of available iron to the cell precludes deficiency of the metal and either diminishes or eliminates biological effects. General significance: Recognition of the pathway for biological effects after particle exposure to involve a functional deficiency of iron suggests novel therapies such as metal supplementation (e.g. inhaled and oral). In addition, the demonstration of a shared mechanism of biological effects allows understanding the common clinical, physiological, and pathological presentation following exposure to disparate particles. (C) 2016 Published by Elsevier B.V. C1 [Ghio, Andrew J.; Soukup, Joleen M.; Dailey, Lisa A.] US EPA, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC USA. RP Ghio, AJ (reprint author), Human Studies Facil, 104 Mason Farm Rd, Res Triangle Pk, NC 27711 USA. NR 84 TC 1 Z9 1 U1 25 U2 25 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-4165 EI 1872-8006 J9 BBA-GEN SUBJECTS JI Biochim. Biophys. Acta-Gen. Subj. PD DEC PY 2016 VL 1860 IS 12 SI SI BP 2816 EP 2825 DI 10.1016/j.bbagen.2016.05.026 PG 10 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA DY1PK UT WOS:000384866700006 PM 27217087 ER PT J AU Yan, Z Jin, YF An, Z Liu, YY Samet, JM Wu, WD AF Yan, Zhen Jin, Yuefei An, Zhen Liu, Yingying Samet, James M. Wu, Weidong TI Inflammatory cell signaling following exposures to particulate matter and ozone SO BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS LA English DT Article DE Particulate matter; O-3; Cell signaling; Inflammation ID AIRWAY EPITHELIAL-CELLS; GROWTH-FACTOR RECEPTOR; NF-KAPPA-B; DIESEL EXHAUST PARTICLES; LONG-TERM EXPOSURE; OXIDATIVE STRESS; EGF-RECEPTOR; TRANSCRIPTION FACTOR; NALP3 INFLAMMASOME; INTERLEUKIN-8 EXPRESSION AB Background: Particulate matter (PM) and ozone (O-3) are two major ambient air pollutants. Epidemiological and toxicological studies have demonstrated exposure to these pollutants is associated with a variety of adverse health effects, including cardiovascular and respiratory disease, in which inflammation is believed to be a common and essential factor. Scope of review: This review mainly focuses on major inflammatory cell signaling pathways triggered by exposure to PM and O-3. The receptors covered in this review include the EGF receptor, toll like receptor, and NOD-like receptor. Intracellular signaling protein kinases depicted in this review are phosphatidylinositol 3-kinase and mitogen-activated protein kinases. Activation of antioxidant and inflammatory transcription factors such as NrF2 and NF kappa B induced by PM and O-3 is also discussed. Major conclusions: Exposure to PM or O-3 can activate cellular signaling networks including membrane receptors, intracellular kinases and phosphatases, and transcription factors that regulate inflammatory responses. While PM induced cell signaling is associated with resultant ROS, O-3-induced cell signaling implicates phosphates. Notably, the cellular signaling induced by PM and O-3 exposure varies with cell type and physiochemical properties of these pollutants. General significance: Cellular signaling plays a critical role in the regulation of inflammatory pathogenesis. Elucidation of cellular signaling pathways initiated by PM or O-3 cannot only help to uncover the mechanisms of air pollutant toxicity but also provide clues for development of interventional measures against air pollution-induced disorders. (C) 2016 Elsevier B.V. All rights reserved. C1 [Yan, Zhen; Jin, Yuefei] Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan Province, Peoples R China. [An, Zhen; Liu, Yingying; Wu, Weidong] Xinxiang Med Univ, Sch Publ Hlth, 601 Jinsui St, Xinxiang 453003, Henan Province, Peoples R China. [An, Zhen; Liu, Yingying; Wu, Weidong] Xinxiang Med Univ, Xinxiang Key Lab Environm Effects & Intervent, Xinxiang 453003, Henan Province, Peoples R China. [Samet, James M.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC 27599 USA. [Wu, Weidong] Xinxiang Med Univ, Henan Collaborat Innovat Ctr Mol Diag & Lab Med, Xinxiang 453003, Henan Province, Peoples R China. RP Wu, WD (reprint author), Xinxiang Med Univ, Sch Publ Hlth, 601 Jinsui St, Xinxiang 453003, Henan Province, Peoples R China. EM wdwu2013@126.com FU National Natural Science Foundation of China [81573112, 81373030]; Innovation Team of Henan Province on Science and Technology [14IRTSTHN017] FX This study is funded by the National Natural Science Foundation of China (81573112; 81373030), and the award for Innovation Team of Henan Province on Science and Technology (14IRTSTHN017). NR 143 TC 1 Z9 1 U1 33 U2 33 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-4165 EI 1872-8006 J9 BBA-GEN SUBJECTS JI Biochim. Biophys. Acta-Gen. Subj. PD DEC PY 2016 VL 1860 IS 12 SI SI BP 2826 EP 2834 DI 10.1016/j.bbagen.2016.03.030 PG 9 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA DY1PK UT WOS:000384866700007 PM 27015762 ER PT J AU Madden, MC AF Madden, Michael C. TI A paler shade of green? The toxicology of biodiesel emissions: Recent findings from studies with this alternative fuel SO BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS LA English DT Article DE Biodiesel emissions; Petroleum diesel; Lung toxicity; Cardiovascular toxicity; Mutagenicity ID DIESEL EXHAUST PARTICULATE; SOY-BIODIESEL; OXIDATIVE STRESS; PETROLEUM DIESEL; INHALATION EXPOSURE; HYPERTENSIVE-RATS; HEALTH IMPACTS; ALLERGIC MICE; MOUSE LUNG; PARTICLES AB Background: Biodiesel produced primarily from plants and algal feedstocks is believed to have advantages for production and use compared to petroleum and to some other fuel sources. There is some speculation that exposure to biodiesel combustion emissions may not induce biological responses or health effects or at a minimum reduce the effects relative to other fuels. In evaluating the overall environmental and health effects of biodiesel production to end use scenario, empirical data or modeling data based on such data are needed. Scope of review: This manuscript examines the available toxicology reports examining combustion derived bio-diesel emissions since approximately 2007, when our last review of the topic occurred. Toxicity derived from other end uses of biodiesel - e.g., spills, dermal absorption, etc. - are not examined. Findings from biodiesel emissions are roughly divided into three areas: whole non-human animal model exposures; in vitro exposures of mammalian and bacterial cells (used for mutation studies primarily); and human exposures in controlled or other exposure fashions. Major conclusions: Overall, these more current studies clearly demonstrate that biodiesel combustion emission exposure- to either 100% biodiesel or a blend in petroleum diesel- can induce biological effects. There are reports that show biodiesel exposure generally induces more effects or a greater magnitude of effect than petroleum diesel, however there are also a similar number of reports showing the opposite trend. It is unclear whether effects induced by exposure to a blend are greater than exposure to 100% biodiesel. Taken together, the evidence suggest biodiesel emissions can have some similar effects as diesel emissions on inflammatory, vascular, mutagenic, and other responses. General significance: While acute biodiesel exposures can show toxicity with a variety of endpoints, the potential effects on human health need further validation. Additionally there are few or no findings to date on whether bio-diesel emissions can induce effects or even a weaker response that petroleum diesel with repeated exposure scenarios such as in an occupational setting. (C) 2016 Published by Elsevier B.V. C1 [Madden, Michael C.] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Chapel Hill, NC 27514 USA. RP Madden, MC (reprint author), US EPA, 104 Mason Farm Rd,Mail Code 58B, Chapel Hill, NC 27514 USA. EM madden.michael@epa.gov FU U.S. Environmental Protection Agency FX The author wishes to thank Kimberly Swanson (Charlottesville VA) for her input, usually on a daily basis, on comprehensive and global topics related to biodiesel production and use issues. Funding for the authors was derived from internal U.S. Environmental Protection Agency funds. NR 51 TC 1 Z9 1 U1 32 U2 33 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-4165 EI 1872-8006 J9 BBA-GEN SUBJECTS JI Biochim. Biophys. Acta-Gen. Subj. PD DEC PY 2016 VL 1860 IS 12 SI SI BP 2856 EP 2862 DI 10.1016/j.bbagen.2016.05.035 PG 7 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA DY1PK UT WOS:000384866700010 PM 27261091 ER PT J AU Cascio, WE AF Cascio, Wayne E. TI Proposed pathophysiologic framework to explain some excess cardiovascular death associated with ambient air particle pollution: Insights for public health translation SO BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS LA English DT Article DE Air pollution; Particulate matter; Cardiovascular mortality; Sudden death; Pathophysiological mechanisms; Susceptible populations ID HOSPITAL CARDIAC-ARREST; AMERICAN-HEART-ASSOCIATION; ACUTE MYOCARDIAL-INFARCTION; DIESEL-EXHAUST INHALATION; FINE PARTICULATE MATTER; LEFT-VENTRICULAR MASS; SHORT-TERM EXPOSURE; OXIDATIVE STRESS; RATE-VARIABILITY; UNITED-STATES AB The paper proposes a pathophysiologic framework to explain the well-established epidemiological association between exposure to ambient air particle pollution and premature cardiovascular mortality, and offers insights into public health solutions that extend beyond regulatory environmental protections to actions that can be taken by individuals, public health officials, healthcare professionals, city and regional planners, local and state governmental officials and all those who possess the capacity to improve cardiovascular health within the population. The foundation of the framework rests on the contribution of traditional cardiovascular risk factors acting alone and in concert with long-term exposures to air pollutants to create a conditional susceptibility for clinical vascular events, such as myocardial ischemia and infarction; stroke and lethal ventricular arrhythmias. The conceptual framework focuses on the fact that short-term exposures to ambient air particulate matter (PM) are associated with vascular thrombosis (acute coronary syndrome, stroke, deep venous thrombosis, and pulmonary embolism) and electrical dysfunction (ventricular arrhythmia); and that individuals having prevalent heart disease are at greatest risk. Moreover, exposure is concomitant with changes in autonomic nervous system balance, systemic inflammation, and prothrombotic/anti-thrombotic and profibrinolytic-antifibrinolytic balance. Thus, a comprehensive solution to the problem of premature mortality triggered by air pollutant exposure will require compliance with regulations to control ambient air particle pollution levels, minimize exposures to air pollutants, as well as a concerted effort to decrease the number of people at-risk for serious clinical cardiovascular events triggered by air pollutant exposure by improving the overall state of cardiovascular health in the population. This article is part of a Special Issue entitled Air Pollution, edited by Wenjun Ding, Andrew J. Ghio and Weidong Wu. Published by Elsevier B.V. C1 [Cascio, Wayne E.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC USA. RP Cascio, WE (reprint author), Environm Publ Hlth Div, 104 Mason Farm Rd,Mail Code 58-A, Chapel Hill, NC 27514 USA. EM cascio.wayne@epa.gov NR 116 TC 1 Z9 1 U1 27 U2 27 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-4165 EI 1872-8006 J9 BBA-GEN SUBJECTS JI Biochim. Biophys. Acta-Gen. Subj. PD DEC PY 2016 VL 1860 IS 12 SI SI BP 2869 EP 2879 DI 10.1016/j.bbagen.2016.07.016 PG 11 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA DY1PK UT WOS:000384866700012 PM 27451957 ER PT J AU Kodavanti, UP AF Kodavanti, Urmila P. TI Stretching the stress boundary: Linking air pollution health effects to a neurohormonal stress response SO BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS LA English DT Article DE Air pollution; Stress response; Stress hormones; Metabolism; Inflammation ID BROWN-NORWAY RATS; PARTICULATE MATTER; OZONE EXPOSURE; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; OXIDATIVE STRESS; BONE-MARROW; TIME-COURSE; RISK-FACTOR; C-FIBERS AB Inhaled pollutants produce effects in virtually all organ systems in our body and have been linked to chronic diseases including hypertension, atherosclerosis, Alzheimer's and diabetes. A neurohormonal stress response (referred to here as a systemic response produced by activation of the sympathetic nervous system and hypothalamus-pituitary-adrenal (HPA)-axis) has been implicated in a variety of psychological and physical stresses, which involves immune and metabolic homeostatic mechanisms affecting all organs in the body. In this review, we provide new evidence for the involvement of this well-characterized neurohormonal stress response in mediating systemic and pulmonary effects of a prototypic air pollutant ozone. A plethora of systemic metabolic and immune effects are induced in animals exposed to inhaled pollutants, which could result from increased circulating stress hormones. The release of adrenal-derived stress hormones in response to ozone exposure not only mediates systemic immune and metabolic responses, but by doing so, also modulates pulmonary injury and inflammation. With recurring pollutant exposures, these effects can contribute to multi-organ chronic conditions associated with air pollution. This review will cover, 1) the potential mechanisms by which air pollutants can initiate the relay of signals from respiratory tract to brain through trigeminal and vagus nerves, and activate stress responsive regions including hypothalamus; and 2) the contribution of sympathetic and HPA-axis activation in mediating systemic homeostatic metabolic and immune effects of ozone in various organs. The potential contribution of chronic environmental stress in cardiovascular, neurological, reproductive and metabolic diseases, and the knowledge gaps are also discussed. This article is part of a Special Issue entitled Air Pollution, edited by Wenjun Ding, Andrew J. Ghio and Weidong Wu. Published by Elsevier B.V. C1 [Kodavanti, Urmila P.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. RP Kodavanti, UP (reprint author), US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. EM kodavanti.urmila@epa.gov NR 136 TC 2 Z9 2 U1 37 U2 37 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-4165 EI 1872-8006 J9 BBA-GEN SUBJECTS JI Biochim. Biophys. Acta-Gen. Subj. PD DEC PY 2016 VL 1860 IS 12 SI SI BP 2880 EP 2890 DI 10.1016/j.bbagen.2016.05.010 PG 11 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA DY1PK UT WOS:000384866700013 PM 27166979 ER PT J AU Tong, HY AF Tong, Haiyan TI Dietary and pharmacological intervention to mitigate the cardiopulmonary effects of air pollution toxicity SO BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS LA English DT Article DE Air pollution; Cardiopulmonary toxicity; Intervention; Dietary supplementations; Medications ID HEART-RATE-VARIABILITY; POLYUNSATURATED FATTY-ACIDS; RANDOMIZED CONTROLLED-TRIAL; VITAMIN-E SUPPLEMENTATION; RAT VENTRICULAR MYOCYTES; CARDIOVASCULAR-DISEASE; ANTIOXIDANT SUPPLEMENTATION; PARTICULATE MATTER; OLIVE OIL; FISH-OIL AB Background: Exposure to air pollution contributes importantly to excess morbidity and mortality. And while regulatory actions under the "Clean Air Act" have saved millions of lives by improving air quality, there are still millions of people in the U.S. who live in areas where particulate air pollution (PM) levels exceed the U.S. Environmental Protection Agency's National Ambient Air Quality Standards. Therefore, apart from such localities working to attain such standards the protection of the health of public and in particular those at high risk might benefit from interventional strategies that would ameliorate air pollution's adverse health effects. Because inflammation and oxidative stress appear to mediate the health effects of air pollution, one interventional approach to consider is the use of dietary supplementation or medication with anti-inflammatory or antioxidant properties to block the biological responses that initiate the pathophysiological process that culminates in adverse health effects. Scope of review: This article reviews the capability of dietary supplementation, such as antioxidant vitamins, polyunsaturated fatty acids, and medications as a strategy to mitigate air pollution-induced subclinical cardiopulmonary effects. Major conclusions: Antioxidant vitamins C and E protect the lungs against short-term ozone and PM exposure. Polyunsaturated fatty acids, such as fish oil and olive oil appear to offer protection against short-term air pollution-induced adverse cardiovascular responses. General significance: Taking dietary supplements or medications with antioxidant or anti-inflammatory properties has the potential to provide at least partial protection against air pollution-induced adverse health effects in those individuals who are known to be most susceptible, namely those with pre-existing respiratory and cardiovascular diseases. This article is part of a Special Issue entitled Air Pollution, edited by Wenjun Ding, Andrew J. Ghio and Weidong Wu. (C) 2016 Published by Elsevier B.V. C1 [Tong, Haiyan] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC 27514 USA. [Tong, Haiyan] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, 58D,109 TW Alexander Dr, Chapel Hill, NC 27711 USA. RP Tong, HY (reprint author), US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC 27514 USA.; Tong, HY (reprint author), US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, 58D,109 TW Alexander Dr, Chapel Hill, NC 27711 USA. EM tong.haiyan@epa.gov FU U.S. Environmental Protection Agency Intramural Research Program FX I would like to thank Drs. James Samet and Wayne Cascio for their insight of this synthesis study and critical review of this manuscript. The U.S. Environmental Protection Agency Intramural Research Program supported the research. NR 78 TC 0 Z9 0 U1 24 U2 24 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-4165 EI 1872-8006 J9 BBA-GEN SUBJECTS JI Biochim. Biophys. Acta-Gen. Subj. PD DEC PY 2016 VL 1860 IS 12 SI SI BP 2891 EP 2898 DI 10.1016/j.bbagen.2016.05.014 PG 8 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA DY1PK UT WOS:000384866700014 PM 27189803 ER PT J AU Kinoshita, Y Yoshizawa, K Emoto, Y Yuki, M Yuri, T Shikata, N Elmore, SA Tsubura, A AF Kinoshita, Yuichi Yoshizawa, Katsuhiko Emoto, Yuko Yuki, Michiko Yuri, Takashi Shikata, Nobuaki Elmore, Susan A. Tsubura, Airo TI A spontaneously occurring malignant ovarian Sertoli cell tumor in a young Sprague Dawley rat SO JOURNAL OF TOXICOLOGIC PATHOLOGY LA English DT Article DE immunohistochemistry; malignant tumor; ovary; Sertoli cell; spontaneous; young rat ID LESIONS; NEOPLASMS; MICE AB Primary ovarian tumors are generally uncommon in rats used in toxicologic studies. A malignant Sertoli cell tumor was present in the ovary of a 19-week-old female Sprague Dawley rat. Macroscopically, the mass was white and firm, 10 x 13 x 17 mm in size, and located in the right ovary. Histopathologically, the mass was composed of nests of pleomorphic cells, which formed seminiferous-like tubules separated by a thin fibrovascular stroma. The tubules were lined by tumor cells, which had basally located nuclei and abundant eosinophilic and vacuolated cytoplasm. In some areas, the tumor cells were arranged in a retiform growth pattern, mimicking a rete testis/ovarii. Disseminated metastases to the surfaces of the mesentery, spleen and liver were also present. Immunohistochemically, many tumor cells were strongly positive for vimentin, estrogen receptor a and Ki 67. Some tumor cells were positive for pancytokeratin and inhibin a. These findings closely resemble those of an ovarian-derived human malignant Sertoli cell tumor. From our review of the literature, we believe this is the first report of a spontaneous malignant Sertoli cell tumor in the ovary of a young laboratory rat. This case might provide useful historical control information for rat toxicity studies. C1 [Kinoshita, Yuichi; Yoshizawa, Katsuhiko; Emoto, Yuko; Yuki, Michiko; Yuri, Takashi; Tsubura, Airo] Kansai Med Univ, Dept Pathol 2, 2-5-1 Shin Machi, Hirakata, Osaka 5731010, Japan. [Kinoshita, Yuichi; Shikata, Nobuaki] Kansai Med Univ, Takii Hosp, Div Diagnost Cytopathol & Histopathol, Fumizono 10-15, Moriguchi, Osaka 5708507, Japan. [Elmore, Susan A.] Natl Inst Environm Hlth Sci, Cellular & Mol Pathol Branch, 111 TW Alexander Dr, Res Triangle Pk, NC 27709 USA. RP Yoshizawa, K (reprint author), Kansai Med Univ, Dept Pathol 2, 2-5-1 Shin Machi, Hirakata, Osaka 5731010, Japan. EM yoshizak@hirakata.kmu.co.jp FU MEXT FX The authors would like to thank Dr. Darlene Dixon of the Molecular Pathogenesis Group, National Toxicology Program Laboratory, National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, USA, and Dr. Tomo Sasaki and Dr. Takayasu Moroki, Department of Toxicological Research, Research Laboratories, Maruho Co. Ltd., Japan, for their review and critical discussion of this case. In connection with this paper, there is no conflict of interest with any of the author's companies to be disclosed. This project was supported by a grant from MEXT-Supported Programs for the Strategic Research Foundations at Private Universities. NR 27 TC 1 Z9 1 U1 52 U2 119 PU JAPANESE SOC TOXICOLOGIC PATHOLOGY PI TOKYO PA DEPT ACAD SOC, MEDICAL TRIBUNE INC, ITALIAN CULTURAL INST BLDG 8F 2-1-30, KUDAN MINAMI, CHIYODA, TOKYO, 102-0074, JAPAN SN 0914-9198 EI 1881-915X J9 J TOXICOL PATHOL JI J. Toxicol. Pathol. PD WIN PY 2016 VL 29 IS 1 BP 53 EP 59 DI 10.1293/tox.2015-0057 PG 7 WC Pathology; Toxicology SC Pathology; Toxicology GA DC9TZ UT WOS:000369565300008 PM 26989303 ER PT J AU Ji, J Qin, YF Wang, R Huang, ZY Zhang, Y Zhou, R Song, L Ling, XF Hu, ZB Miao, DS Shen, HB Xia, YK Wang, XR Lu, CC AF Ji, Juan Qin, Yufeng Wang, Rong Huang, Zhenyao Zhang, Yan Zhou, Ran Song, Ling Ling, Xiufeng Hu, Zhibin Miao, Dengshun Shen, Hongbing Xia, Yankai Wang, Xinru Lu, Chuncheng TI Copy number gain of VCX, X-linked multi-copy gene, leads to cell proliferation and apoptosis during spermatogenesis SO ONCOTARGET LA English DT Article DE copy number variations; non-obstructive azoospermia ID SEX-CHROMOSOME INACTIVATION; MALE-INFERTILITY; NONOBSTRUCTIVE AZOOSPERMIA; Y-CHROMOSOME; CANCER/TESTIS ANTIGENS; GERM-CELLS; MALE-MICE; VARIANTS; MUTATIONS; FAILURE AB Male factor infertility affects one-sixth of couples worldwide, and non-obstructive azoospermia (NOA) is one of the most severe forms. In recent years there has been increasing evidence to implicate the participation of X chromosome in the process of spermatogenesis. To uncover the roles of X-linked multi-copy genes in spermatogenesis, we performed systematic analysis of X-linked gene copy number variations (CNVs) and Y chromosome haplogrouping in 447 idiopathic NOA patients and 485 healthy controls. Interestingly, the frequency of individuals with abnormal level copy of Variable charge, X-linked (VCX) was significantly different between cases and controls after multiple test correction (p = 5.10 x 10(-5)). To discriminate the effect of gain/loss copies in these genes, we analyzed the frequency of X-linked multi-copy genes in subjects among subdivided groups. Our results demonstrated that individuals with increased copy numbers of Nuclear RNA export factor 2 (NXF2) (p = 9.21 x 10(-8)) and VCX (p = 1.97 x 10(-4)) conferred the risk of NOA. In vitro analysis demonstrated that increasing copy number of VCX could upregulate the gene expression and regulate cell proliferation and apoptosis. Our study establishes a robust association between the VCX CNVs and NOA risk. C1 [Ji, Juan; Huang, Zhenyao; Zhang, Yan; Zhou, Ran; Song, Ling; Hu, Zhibin; Miao, Dengshun; Shen, Hongbing; Xia, Yankai; Wang, Xinru; Lu, Chuncheng] Nanjing Med Univ, Inst Toxicol, State Key Lab Reprod Med, Nanjing, Jiangsu, Peoples R China. [Ji, Juan; Huang, Zhenyao; Zhang, Yan; Zhou, Ran; Song, Ling; Xia, Yankai; Wang, Xinru; Lu, Chuncheng] Nanjing Med Univ, Sch Publ Hlth, Minist Educ, Key Lab Modern Toxicol, Nanjing, Jiangsu, Peoples R China. [Qin, Yufeng] Natl Inst Environm Hlth Sci, Epigenet & Stem Cell Biol Lab, Res Triangle Pk, NC USA. [Ji, Juan; Ling, Xiufeng] Nanjing Med Univ, Nanjing Matern & Child Hlth Care Hosp, Dept Children Hlth Care, Nanjing, Jiangsu, Peoples R China. [Wang, Rong; Miao, Dengshun] Nanjing Med Univ, Dept Anat Histol & Embryol, Res Ctr Bone & Stem Cells, Nanjing, Jiangsu, Peoples R China. [Hu, Zhibin; Shen, Hongbing] Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Nanjing, Jiangsu, Peoples R China. [Hu, Zhibin; Shen, Hongbing] Nanjing Med Univ, Sch Publ Hlth, Minist Educ, Key Lab Modern Toxicol, Nanjing, Jiangsu, Peoples R China. RP Lu, CC (reprint author), Nanjing Med Univ, Inst Toxicol, State Key Lab Reprod Med, Nanjing, Jiangsu, Peoples R China.; Lu, CC (reprint author), Nanjing Med Univ, Sch Publ Hlth, Minist Educ, Key Lab Modern Toxicol, Nanjing, Jiangsu, Peoples R China. EM chunchenglu@njmu.edu.cn FU National Natural Science Foundation of China [81471500, 81671461, 81322039]; Priority Academic Program for the Development of Jiangsu Higher Education Institutions (Public Health and Preventive Medicine); [BK20130041] FX We thank all the research staff and students who took part in this work. Funding was provided by grants from the National Natural Science Foundation of China (81471500, 81671461 and 81322039), Distinguished Young Scholars of Jiangsu Province (BK20130041) and the Priority Academic Program for the Development of Jiangsu Higher Education Institutions (Public Health and Preventive Medicine). NR 54 TC 0 Z9 0 U1 1 U2 1 PU IMPACT JOURNALS LLC PI ALBANY PA 6211 TIPTON HOUSE, STE 6, ALBANY, NY 12203 USA SN 1949-2553 J9 ONCOTARGET JI Oncotarget PD NOV 29 PY 2016 VL 7 IS 48 BP 78532 EP 78540 DI 10.18632/oncotarget.12397 PG 9 WC Oncology; Cell Biology SC Oncology; Cell Biology GA EE5HH UT WOS:000389636000028 PM 27705943 ER PT J AU Fuka, DR Collick, AS Kleinman, PJA Auerbach, DA Harmel, RD Easton, ZM AF Fuka, Daniel R. Collick, Amy S. Kleinman, Peter J. A. Auerbach, Daniel A. Harmel, R. Daren Easton, Zachary M. TI Improving the spatial representation of soil properties and hydrology using topographically derived initialization processes in the SWAT model SO HYDROLOGICAL PROCESSES LA English DT Article DE SWAT model; infiltration excess runoff; soil characteristics; topography; surface characterization; Hortonian runoff; non-point source ID WATER ASSESSMENT-TOOL; PEDOTRANSFER FUNCTIONS; SOURCE AREAS; RUNOFF; TEXAS; SYSTEM; FUTURE; PARAMETERS; TERRAIN; USA AB Topography exerts critical controls on many hydrologic, geomorphologic and biophysical processes. However, many watershed modelling systems use topographic data only to define basin boundaries and stream channels, neglecting opportunities to account for topographic controls on processes such as soil genesis, soil moisture distributions and hydrological response. Here, we demonstrate a method that uses topographic data to adjust spatial soil morphologic and hydrologic attributes: texture, depth to the C-horizon, saturated conductivity, bulk density, porosity and the water capacities at field (33 kpa) and wilting point (1500 kpa) tensions. As a proof of concept and initial performance test, the values of the topographically adjusted soil parameters and those from the Soil Survey Geographic Database (SSURGO; available at 1 : 20 000 scale) were compared with measured soil pedon pit data in the Grasslands Soil and Water Research Lab watershed in Riesel, TX. The topographically adjusted soils were better correlated with the pit measurements than were the SSURGO values. We then incorporated the topographically adjusted soils into an initialization of the Soil and Water Assessment Tool model for 15 Riesel research watersheds to investigate how changes in soil properties influence modelled hydrological responses at the field scale. The results showed that the topographically adjusted soils produced better runoff predictions in 50% of the fields, with the SSURGO soils performing better in the remainder. In addition, the a priori adjusted soils result in fewer calibrated model parameters. These results indicate that adjusting soil properties based on topography can result in more accurate soil characterization and, in some cases, improve model performance. Copyright (C) 2016 John Wiley & Sons, Ltd. C1 [Fuka, Daniel R.; Easton, Zachary M.] Virginia Tech, Dept Biol Syst Engn, Blacksburg, VA 24061 USA. [Collick, Amy S.; Kleinman, Peter J. A.] USDA ARS, Pasture Syst & Watershed Management Res Unit, University Pk, PA USA. [Auerbach, Daniel A.] Cornell Univ, Dept Ecol & Evolutionary Biol, Ithaca, NY 14853 USA. [Harmel, R. Daren] USDA ARS, Grassland Soil & Water Res Lab, Temple, TX 76502 USA. [Collick, Amy S.] Univ Maryland Eastern Shore, Dept Agr Food & Resource Sci, Princess Anne, MD 21853 USA. [Auerbach, Daniel A.] US EPA, Off Wetlands Oceans & Watersheds, Washington, DC 20460 USA. RP Auerbach, DA (reprint author), Cornell Univ, Dept Ecol & Evolutionary Biol, Ithaca, NY 14853 USA. EM auerbach.dan@gmail.com OI Auerbach, Daniel/0000-0002-3655-5206 FU NSF [1343802]; USDA NRCS Conservation Innovation Grants Program [69-3A75-13-232]; NatureNet postdoctoral fellowship from The Nature Conservancy FX We would like to acknowledge the funding support from NSF [award no. 1343802, EarthCube Building Blocks: A Broker Framework for Next Generation Geoscience (BCube)], USDA NRCS Conservation Innovation Grants Program (award no. 69-3A75-13-232), a NatureNet postdoctoral fellowship from The Nature Conservancy, and computational support from National Center for Atmospheric Research (Computational and Information Systems Laboratory. 2015. Yellowstone: IBM iDataPlex System (NCAR Community Computing). Boulder, CO: National Center for Atmospheric Research. http://n2t.net/ark:/85065/d7wd3xhc). NR 65 TC 1 Z9 1 U1 13 U2 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0885-6087 EI 1099-1085 J9 HYDROL PROCESS JI Hydrol. Process. PD NOV 29 PY 2016 VL 30 IS 24 BP 4633 EP 4643 DI 10.1002/hyp.10899 PG 11 WC Water Resources SC Water Resources GA ED3GP UT WOS:000388737900013 ER PT J AU Zhang, YP Williams, BJ Goldstein, AH Docherty, KS Jimenez, JL AF Zhang, Yaping Williams, Brent J. Goldstein, Allen H. Docherty, Kenneth S. Jimenez, Jose L. TI A technique for rapid source apportionment applied to ambient organic aerosol measurements from a thermal desorption aerosol gas chromatograph (TAG) SO ATMOSPHERIC MEASUREMENT TECHNIQUES LA English DT Article ID POSITIVE MATRIX FACTORIZATION; HOURLY MEASUREMENTS; MASS-SPECTROMETER; PARTICLE; INSTRUMENT; ATMOSPHERE; COMPONENTS; PM2.5 AB We present a rapid method for apportioning the sources of atmospheric organic aerosol composition measured by gas chromatography-mass spectrometry methods. Here, we specifically apply this new analysis method to data acquired on a thermal desorption aerosol gas chromatograph (TAG) system. Gas chromatograms are divided by retention time into evenly spaced bins, within which the mass spectra are summed. A previous chromatogram binning method was introduced for the purpose of chromatogram structure deconvolution (e.g., major compound classes) (Zhang et al., 2014). Here we extend the method development for the specific purpose of determining aerosol samples' sources. Chromatogram bins are arranged into an input data matrix for positive matrix factorization (PMF), where the sample number is the row dimension and the mass-spectra-resolved eluting time intervals (bins) are the column dimension. Then two-dimensional PMF can effectively do three-dimensional factorization on the three-dimensional TAG mass spectra data. The retention time shift of the chromatogram is corrected by applying the median values of the different peaks' shifts. Bin width affects chemical resolution but does not affect PMF retrieval of the sources' time variations for low-factor solutions. A bin width smaller than the maximum retention shift among all samples requires retention time shift correction. A six-factor PMF comparison among aerosol mass spectrometry (AMS), TAG binning, and conventional TAG compound integration methods shows that the TAG binning method performs similarly to the integration method. However, the new binning method incorporates the entirety of the data set and requires significantly less pre-processing of the data than conventional single compound identification and integration. In addition, while a fraction of the most oxygenated aerosol does not elute through an underivatized TAG analysis, the TAG binning method does have the ability to achieve molecular level resolution on other bulk aerosol components commonly observed by the AMS. C1 [Zhang, Yaping; Williams, Brent J.] Washington Univ, Dept Energy Environm & Chem Engn, St Louis, MO 63130 USA. [Goldstein, Allen H.] Univ Calif Berkeley, Dept Environm Sci Policy & Management, Berkeley, CA 94720 USA. [Docherty, Kenneth S.; Jimenez, Jose L.] Univ Colorado, CIRES, Boulder Creek, CA USA. [Docherty, Kenneth S.; Jimenez, Jose L.] Univ Colorado, Dept Chem & Biochem, Boulder, CO USA. [Docherty, Kenneth S.] US EPA, Alion Sci & Technol, Off Res & Dev, Res Triangle Pk, NC USA. RP Williams, BJ (reprint author), Washington Univ, Dept Energy Environm & Chem Engn, St Louis, MO 63130 USA. EM brentw@wustl.edu RI Jimenez, Jose/A-5294-2008 OI Jimenez, Jose/0000-0001-6203-1847 FU NSF [1437933, 1554061]; California Air Resources Board (CARB) [03-324]; EPA STAR [83587701-0]; DOE (BER/ASR) [DE-SC0011105] FX Brent J. Williams and Yaping Zhang were supported by NSF 1437933 and NSF 1554061; Allen Goldstein and SOAR TAG data collection were supported by California Air Resources Board (CARB) award 03-324.; Jose L. Jimenez and Kenneth Docherty were supported by EPA STAR 83587701-0 and DOE (BER/ASR) DE-SC0011105. This paper has not been reviewed by the EPA, and thus no endorsement should be inferred. NR 35 TC 0 Z9 0 U1 5 U2 5 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1867-1381 EI 1867-8548 J9 ATMOS MEAS TECH JI Atmos. Meas. Tech. PD NOV 25 PY 2016 VL 9 IS 11 BP 5637 EP 5653 DI 10.5194/amt-9-5637-2016 PG 17 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA ED2UU UT WOS:000388706100003 ER PT J AU Dionisio, KL Chang, HH Baxter, LK AF Dionisio, Kathie L. Chang, Howard H. Baxter, Lisa K. TI A simulation study to quantify the impacts of exposure measurement error on air pollution health risk estimates in copollutant time-series models SO ENVIRONMENTAL HEALTH LA English DT Article DE Exposure modeling; Exposure measurement error; Exposure assessment; Bias; Copollutant ID RESPIRATORY SYMPTOMS; ATLANTA; EPIDEMIOLOGY; POLLUTANTS; CHILDREN; METRICS AB Background: Exposure measurement error in copollutant epidemiologic models has the potential to introduce bias in relative risk (RR) estimates. A simulation study was conducted using empirical data to quantify the impact of correlated measurement errors in time-series analyses of air pollution and health. Methods: ZIP-code level estimates of exposure for six pollutants (CO, NOx, EC, PM2.5, SO4, O-3) from 1999 to 2002 in the Atlanta metropolitan area were used to calculate spatial, population (i.e. ambient versus personal), and total exposure measurement error. Empirically determined covariance of pollutant concentration pairs and the associated measurement errors were used to simulate true exposure (exposure without error) from observed exposure. Daily emergency department visits for respiratory diseases were simulated using a Poisson time-series model with a main pollutant RR = 1.05 per interquartile range, and a null association for the copollutant (RR = 1). Monte Carlo experiments were used to evaluate the impacts of correlated exposure errors of different copollutant pairs. Results: Substantial attenuation of RRs due to exposure error was evident in nearly all copollutant pairs studied, ranging from 10 to 40% attenuation for spatial error, 3-85% for population error, and 31-85% for total error. When CO, NOx or EC is the main pollutant, we demonstrated the possibility of false positives, specifically identifying significant, positive associations for copollutants based on the estimated type I error rate. Conclusions: The impact of exposure error must be considered when interpreting results of copollutant epidemiologic models, due to the possibility of attenuation of main pollutant RRs and the increased probability of false positives when measurement error is present. C1 [Dionisio, Kathie L.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Chang, Howard H.] Emory Univ, Dept Biostat & Bioinformat, Atlanta, GA 30322 USA. [Baxter, Lisa K.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. RP Dionisio, KL (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. EM dionisio.kathie@epa.gov FU US EPA [R834799]; National Institutes of Health [R21ES022795-02] FX This publication was made possible in part by US EPA grant R834799 and by grant R21ES022795-02 from the National Institutes of Health. Funding bodies did not play a role in the study design, data analysis, interpretation of results, or manuscript writing. NR 32 TC 0 Z9 0 U1 6 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1476-069X J9 ENVIRON HEALTH-GLOB JI Environ. Health PD NOV 25 PY 2016 VL 15 AR 114 DI 10.1186/s12940-016-0186-0 PG 10 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA ED3SP UT WOS:000388769100002 PM 27884187 ER PT J AU Pennino, MJ Kaushal, SS Murthy, SN Blomquist, JD Cornwell, JC Harris, LA AF Pennino, Michael J. Kaushal, Sujay S. Murthy, Sudhir N. Blomquist, Joel D. Cornwell, Jeff C. Harris, Lora A. TI Sources and transformations of anthropogenic nitrogen along an urban river-estuarine continuum SO BIOGEOSCIENCES LA English DT Article ID OXYGEN-ISOTOPE FRACTIONATION; DISSOLVED INORGANIC NITROGEN; COASTAL-PLAIN ESTUARY; CHESAPEAKE BAY; NITRATE SOURCES; SALINITY GRADIENT; POTOMAC RIVER; DENITRIFICATION RATES; ORGANIC-CARBON; MARINE DIATOM AB Urbanization has altered the fate and transport of anthropogenic nitrogen (N) in rivers and estuaries globally. This study evaluates the capacity of an urbanizing river-estuarine continuum to transform N inputs from the world's largest advanced (e.g., phosphorus and biological N removal) wastewater treatment facility. Effluent samples and surface water were collected monthly along the Potomac River estuary from Washington D.C. to the Chesapeake Bay over a distance of 150 km. In conjunction with box model mass balances, nitrate stable isotopes and mixing models were used to trace the fate of urban wastewater nitrate. Nitrate concentrations and delta N-15-NO3- values were higher down-estuary from the Blue Plains wastewater outfall in Washington D.C. (2.25 +/- 0.62 mg L-1 and 25.7 +/- 2.9 %, respectively) compared to upper-estuary concentrations (1.0 +/- 0.2 mg L-1 and 9.3 +/- 1.4 %, respectively). Nitrate concentration then decreased rapidly within 30 km down-estuary (to 0.8 +/- 0.2 mg L-1), corresponding to an increase in organic nitrogen and dissolved organic carbon, suggesting biotic uptake and organic transformation. TN loads declined down-estuary (from an annual average of 48 000 +/- 5000 kg day(-1) at the sewage treatment plant outfall to 23 000 +/- 13 000 kg day(-1)at the estuary mouth), with the greatest percentage decrease during summer and fall. Annually, there was a 70 +/- 31% loss in wastewater NO3- along the estuary, and 28 +/- 6% of urban wastewater TN inputs were exported to the Chesapeake Bay, with the greatest contribution of wastewater TN loads during the spring. Our results suggest that biological transformations along the urban riverestuary continuum can significantly transform wastewater N inputs from major cities globally, and more work is necessary to evaluate the potential of organic nitrogen and carbon to contribute to eutrophication and hypoxia. C1 [Pennino, Michael J.; Kaushal, Sujay S.] Univ Maryland, Dept Geol, College Pk, MD 20742 USA. [Pennino, Michael J.; Kaushal, Sujay S.] Univ Maryland, Earth Syst Sci Interdisciplinary Ctr, College Pk, MD 20742 USA. [Murthy, Sudhir N.] DC Water, Off Gen Manager, Washington, DC USA. [Blomquist, Joel D.] US Geol Survey, Maryland Delaware & Dist Columbia Water Sci Ctr, Baltimore, MD USA. [Cornwell, Jeff C.] Univ Maryland, Horn Point Lab, Ctr Environm Sci, Cambridge, MD USA. [Harris, Lora A.] Univ Maryland, Chesapeake Biol Lab, Ctr Environm Sci, Solomons, MD 20688 USA. [Pennino, Michael J.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Corvallis, OR 97333 USA. RP Pennino, MJ (reprint author), Univ Maryland, Dept Geol, College Pk, MD 20742 USA.; Pennino, MJ (reprint author), Univ Maryland, Earth Syst Sci Interdisciplinary Ctr, College Pk, MD 20742 USA.; Pennino, MJ (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Corvallis, OR 97333 USA. EM michael.pennino@gmail.com RI Cornwell, Jeffrey/R-5506-2016 OI Cornwell, Jeffrey/0000-0001-7111-2489 FU Washington D.C. Water and Sewer Authority FX This research was supported by the Washington D.C. Water and Sewer Authority. We would like to thank Sally Bowen and Matt Hall from the Maryland Department of Natural Resources (DNR) for their assistance in collecting monthly water samples along the Potomac Estuary and David Brower at the US Geological Survey for help in collecting monthly river input samples for the Potomac River. We acknowledge the input provided by Lewis Linker and Ping Wang of the US EPA Chesapeake Bay Program's Modeling Team for providing simulated output from the CE QUAL ICEM model at three flux boundaries in the Potomac for comparison with our box model output. Gratitude is extended to Jeremy Testa for his suggestions regarding the box model effort. Tom Jordan also provided helpful suggestions. NR 85 TC 0 Z9 0 U1 25 U2 25 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1726-4170 EI 1726-4189 J9 BIOGEOSCIENCES JI Biogeosciences PD NOV 18 PY 2016 VL 13 IS 22 BP 6211 EP 6228 DI 10.5194/bg-13-6211-2016 PG 18 WC Ecology; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Geology GA ED2RD UT WOS:000388695100001 ER PT J AU Schroeder, JR Crawford, JH Fried, A Walega, J Weinheimer, A Wisthaler, A Muller, M Mikoviny, T Chen, G Shook, M Blake, DR Diskin, G Estes, M Thompson, AM Lefer, BL Long, R Mattson, E AF Schroeder, Jason R. Crawford, James H. Fried, Alan Walega, James Weinheimer, Andrew Wisthaler, Armin Muller, Markus Mikoviny, Tomas Chen, Gao Shook, Michael Blake, Donald R. Diskin, Glenn Estes, Mark Thompson, Anne M. Lefer, Barry L. Long, Russell Mattson, Eric TI Formaldehyde column density measurements as a suitable pathway to estimate near-surface ozone tendencies from space SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID VOLATILE ORGANIC-COMPOUNDS; US INTERMOUNTAIN WEST; AIR-QUALITY; TROPOSPHERIC OZONE; SATELLITE-OBSERVATIONS; AIRBORNE OBSERVATIONS; TEMPORAL VARIABILITY; STATISTICAL-ANALYSIS; ISOPRENE EMISSIONS; OMI OBSERVATIONS AB In support of future satellite missions that aim to address the current shortcomings in measuring air quality from space, NASA's Deriving Information on Surface Conditions from Column and Vertically Resolved Observations Relevant to Air Quality (DISCOVER-AQ) field campaign was designed to enable exploration of relationships between column measurements of trace species relevant to air quality at high spatial and temporal resolution. In the DISCOVER-AQ data set, a modest correlation (r(2) = 0.45) between ozone (O-3) and formaldehyde (CH2O) column densities was observed. Further analysis revealed regional variability in the O-3-CH2O relationship, with Maryland having a strong relationship when data were viewed temporally and Houston having a strong relationship when data were viewed spatially. These differences in regional behavior are attributed to differences in volatile organic compound (VOC) emissions. In Maryland, biogenic VOCs were responsible for similar to 28% of CH2O formation within the boundary layer column, causing CH2O to, in general, increase monotonically throughout the day. In Houston, persistent anthropogenic emissions dominated the local hydrocarbon environment, and no discernable diurnal trend in CH2O was observed. Box model simulations suggested that ambient CH2O mixing ratios have a weak diurnal trend (+/- 20% throughout the day) due to photochemical effects, and that larger diurnal trends are associated with changes in hydrocarbon precursors. Finally, mathematical relationships were developed from first principles and were able to replicate the different behaviors seen in Maryland and Houston. While studies would be necessary to validate these results and determine the regional applicability of the O-3-CH2O relationship, the results presented here provide compelling insight into the ability of future satellite missions to aid in monitoring near-surface air quality. C1 [Schroeder, Jason R.; Crawford, James H.; Chen, Gao; Shook, Michael; Diskin, Glenn] NASA, Langley Res Ctr, Hampton, VA 23665 USA. [Schroeder, Jason R.] NASA Langley Res Ctr, NASA Postdoctoral Program, Hampton, VA 23666 USA. [Fried, Alan; Walega, James] Univ Colorado, Inst Arctic & Alpine Res, Boulder, CO 80309 USA. [Weinheimer, Andrew] Natl Ctr Atmospher Res, POB 3000, Boulder, CO 80307 USA. [Wisthaler, Armin; Muller, Markus] Univ Innsbruck, Inst Ion Phys & Appl Phys, Innsbruck, Austria. [Wisthaler, Armin; Mikoviny, Tomas] Univ Oslo, Dept Chem, Oslo, Norway. [Blake, Donald R.] Univ Calif Irvine, Dept Chem, Irvine, CA 92717 USA. [Estes, Mark] Texas Commiss Environm Qual, Austin, TX USA. [Thompson, Anne M.] Penn State Univ, Dept Meteorol, 503 Walker Bldg, University Pk, PA 16802 USA. [Thompson, Anne M.] NASA Goddard Space Flight, Greenbelt, MD USA. [Lefer, Barry L.] Univ Houston, Dept Earth & Atmospher Sci, Houston, TX USA. [Lefer, Barry L.] NASA Headquarters, Washington, DC USA. [Long, Russell] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Mattson, Eric] Colorado Dept Publ Hlth & Environm, Denver, CO USA. RP Schroeder, JR (reprint author), NASA, Langley Res Ctr, Hampton, VA 23665 USA.; Schroeder, JR (reprint author), NASA Langley Res Ctr, NASA Postdoctoral Program, Hampton, VA 23666 USA. EM Jason.r.schroeder@nasa.gov RI Lefer, Barry/B-5417-2012; Thompson, Anne /C-3649-2014; Muller, Markus/L-1699-2014 OI Lefer, Barry/0000-0001-9520-5495; Thompson, Anne /0000-0002-7829-0920; Muller, Markus/0000-0003-4110-8950 FU Austrian Ministry for Transport, Innovation, and Technology through the Austrian Space Applications Program of the Austrian Research Promotion Agency (FFG); NASA; Visiting Scientist Program of the National Institute of Aerospace FX All data used in this work can be downloaded from: http://www-air.larc.nasa.gov/missions/discover-aq/discover-aq.html. PTR-MS measurements during DISCOVER-AQ were supported by the Austrian Ministry for Transport, Innovation, and Technology through the Austrian Space Applications Program of the Austrian Research Promotion Agency (FFG). Jason Schroeder and Tomas Mikoviny were partially supported by an appointment with the NASA Postdoctoral Program at NASA Langley Research Center, administered by Oak Ridge Associated Universities through a contract with NASA. Armin Wisthaler and Markus Muller received support from the Visiting Scientist Program of the National Institute of Aerospace. The authors would like to thank the thoughtful reviewers who gave valuable input into making this paper better. NR 84 TC 0 Z9 0 U1 7 U2 7 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X EI 2169-8996 J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD NOV 16 PY 2016 VL 121 IS 21 BP 13088 EP 13112 DI 10.1002/2016JD025419 PG 25 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA ED6IZ UT WOS:000388960600029 ER PT J AU Chen, T Xu, J Liu, GQ Liu, H Chen, MJ Qin, YF Wu, W Xia, YK Ji, CB Guo, XR Wen, J Wang, XR AF Chen, Ting Xu, Juan Liu, Guangquan Liu, Heng Chen, Minjian Qin, Yufeng Wu, Wei Xia, Yankai Ji, Chenbo Guo, Xirong Wen, Juan Wang, Xinru TI Genetic variants in PTPRD and risk of gestational diabetes mellitus SO ONCOTARGET LA English DT Article DE PTPRD; polymorphism; gestational diabetes mellitus; susceptibility ID GENOME-WIDE ASSOCIATION; PROTEIN-TYROSINE-PHOSPHATASE; WOMEN; LAR; METAANALYSIS; SIGNALS; DELTA; LEADS; SIGMA; MICE AB Genome-wide association studies (GWASs) showed that two single nucleotide polymorphisms (SNPs) (rs17584499 and rs649891) in the protein tyrosine phosphatase receptor type D (PTPRD) were associated with type 2 diabetes (T2D). We sought to determine the influence of the PTPRD variants on the gestational diabetes mellitus (GDM) risk. In this research, two SNPs in PTPRD reported in T2D GWASs and six PTPRD expression-related SNPs were genotyped in 964 GDM cases and 1,021 controls using the Sequenom platform. Logistic regression analyses in additive models showed consistently significant associations of PTPRD rs10511544 A>C, rs10756026 T>A and rs10809070 C>G with a decreased risk of GDM [ adjusted OR (95% CI) = 0.83 (0.72-0.97) for rs10511544; adjusted OR (95% CI) = 0.81 (0.70-0.94) for rs10756026; adjusted OR (95% CI) = 0.78 (0.65-0.92) for rs10809070]. Furthermore, the risk of GDM was significantly decreased with an increasing number of variant alleles of the three SNPs in a dose-dependent manner (P-trend = 0.008). Moreover, the haplotype containing variant alleles of the three SNPs were significantly associated with a decreased risk of GDM [ adjusted OR (95% CI) = 0.77 (0.64-0.92), P = 0.005], when compared with the most frequent haplotype. However, there were no significant associations for the SNPs reported in the T2D GWASs. Altogether, these findings indicate that the variants of rs10511544, rs10756026 and rs10809070 in PTPRD may contribute to a decreased susceptibility to GDM. Further validation in different ethnic backgrounds and biological function analyses are needed. C1 [Chen, Ting; Chen, Minjian; Wu, Wei; Xia, Yankai; Wang, Xinru] Nanjing Med Univ, Inst Toxicol, State Key Lab Reprod Med, Nanjing 211166, Jiangsu, Peoples R China. [Chen, Ting; Chen, Minjian; Wu, Wei; Xia, Yankai; Wang, Xinru] Nanjing Med Univ, Sch Publ Hlth, Minist Educ, Key Lab Modern Toxicol, Nanjing 211166, Jiangsu, Peoples R China. [Chen, Ting; Xu, Juan; Liu, Guangquan; Liu, Heng; Ji, Chenbo; Guo, Xirong; Wen, Juan] Nanjing Med Univ, Nanjing Matern & Child Hlth Care Hosp, Nanjing Matern & Child Hlth Care Inst, Nanjing 210004, Jiangsu, Peoples R China. [Xu, Juan] Nanjing Med Univ, Nanjing Matern & Child Hlth Care Hosp, Dept Obstet & Gynecol, Nanjing 210004, Jiangsu, Peoples R China. [Qin, Yufeng] Natl Inst Environm Hlth Sci, Epigenet & Stem Cell Biol Lab, Res Triangle Pk, NC 27709 USA. [Ji, Chenbo; Guo, Xirong; Wen, Juan] Nanjing Med Univ, Nanjing Matern & Child Hlth Care Hosp, Dept Children Hlth Care, Nanjing 210004, Jiangsu, Peoples R China. RP Wang, XR (reprint author), Nanjing Med Univ, Inst Toxicol, State Key Lab Reprod Med, Nanjing 211166, Jiangsu, Peoples R China.; Wang, XR (reprint author), Nanjing Med Univ, Sch Publ Hlth, Minist Educ, Key Lab Modern Toxicol, Nanjing 211166, Jiangsu, Peoples R China.; Wen, J (reprint author), Nanjing Med Univ, Nanjing Matern & Child Hlth Care Hosp, Nanjing Matern & Child Hlth Care Inst, Nanjing 210004, Jiangsu, Peoples R China.; Wen, J (reprint author), Nanjing Med Univ, Nanjing Matern & Child Hlth Care Hosp, Dept Children Hlth Care, Nanjing 210004, Jiangsu, Peoples R China. EM wenj2010@gmail.com; xrwang@njmu.edu.cn FU National Natural Science Foundation of China [81401232, 81600685]; Nanjing Medical Science and technique Development Foundation [QRX11222]; Natural Science Foundation of Jiangsu Province [BK20160141]; Science and Technology Development Fund of the Nanjing Medical University [2015NJMUZD062] FX This work was supported in part by the National Natural Science Foundation of China (81401232, 81600685), Nanjing Medical Science and technique Development Foundation (QRX11222), the Natural Science Foundation of Jiangsu Province (BK20160141), and the Science and Technology Development Fund of the Nanjing Medical University (2015NJMUZD062). NR 22 TC 0 Z9 0 U1 0 U2 0 PU IMPACT JOURNALS LLC PI ALBANY PA 6211 TIPTON HOUSE, STE 6, ALBANY, NY 12203 USA SN 1949-2553 J9 ONCOTARGET JI Oncotarget PD NOV 15 PY 2016 VL 7 IS 46 BP 76101 EP 76107 DI 10.18632/oncotarget.12599 PG 7 WC Oncology; Cell Biology SC Oncology; Cell Biology GA EE5GF UT WOS:000389632800129 PM 27738328 ER PT J AU Adeleye, AS Keller, AA AF Adeleye, Adeyemi S. Keller, Arturo A. TI Interactions between Algal Extracellular Polymeric Substances and Commercial TiO2 Nanoparticles in Aqueous Media SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID TITANIUM-DIOXIDE NANOPARTICLES; CARBON NANOTUBES; ORGANIC-MATTER; QUANTUM DOTS; STABILITY; HETEROAGGREGATION; SPECTROSCOPY; AGGREGATION; ADSORPTION; WATERS AB The implications of engineered nanomaterials (ENMs) in the environment are often investigated using pristine particles. However, there are several biogenic and geogenic materials in natural waters that interact with and modify the surface of ENMs, thereby influencing their fate and effects. Here we studied the influence of soluble extracellular polymeric substances (sEPS) produced by freshwater and marine algae on the surface properties and fate of three commercial TiO2 nanoparticles (nTiO(2)) with different coatings. Adsorption of sEPS by the various nTiO(2) is dependent on particle surface area, intrinsic nTiO(2) surface charge, and hydrophobicity. Interactions between sEPS and nTiO(2) were driven by electrostatic interactions and chemical bonding (bridge-coordination) between the COO- group of sEPS and nTiO(2). Charge reversal of positively charged nTiO(2) was observed at pH 7 in the presence of 0.5 mg-C/L sEPS. In addition, the critical coagulation concentration (CCC) of nTiO(2) increased in the presence of sEPS from both freshwater and marine sources. CCC of all nTiO(2) increased as sEPS concentrations increased. This study shows that naturally occurring sEPS can modify the surface properties and fate of nTiO(2) in natural waters, and should be accounted for when predicting the fate and effects of engineered nanomaterials in the environment. C1 [Adeleye, Adeyemi S.; Keller, Arturo A.] Univ Calif Santa Barbara, Bren Sch Environm Sci & Management, Santa Barbara, CA 93106 USA. [Adeleye, Adeyemi S.; Keller, Arturo A.] Univ Calif Santa Barbara, Univ Calif Ctr Environm Implicat Nanotechnol, Santa Barbara, CA 93106 USA. [Adeleye, Adeyemi S.] US Environm Protect Agcy, Atlantic Ecol Div, Narragansett, RI USA. RP Adeleye, AS; Keller, AA (reprint author), Univ Calif Santa Barbara, Bren Sch Environm Sci & Management, Santa Barbara, CA 93106 USA.; Adeleye, AS; Keller, AA (reprint author), Univ Calif Santa Barbara, Univ Calif Ctr Environm Implicat Nanotechnol, Santa Barbara, CA 93106 USA.; Adeleye, AS (reprint author), US Environm Protect Agcy, Atlantic Ecol Div, Narragansett, RI USA. EM adeleye.adeyemi@epa.gov; keller@bren.ucsb.edu FU NSF [DBI 0830117]; EPA [DBI 0830117]; MRSEC Program of the NSF [DMR 1121053] FX This material is based upon work supported by the NSF and the EPA under Cooperative Agreement Number DBI 0830117. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of NSF or EPA. We thank the MRL Central Facilities, which are supported by the MRSEC Program of the NSF under Award No. DMR 1121053, for the use of their instruments. We also thank Paige Rutten for lab assistance, and Dr. Louise Stevenson for providing C. reinhardtii cultures. NR 39 TC 1 Z9 1 U1 18 U2 18 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD NOV 15 PY 2016 VL 50 IS 22 BP 12258 EP 12265 DI 10.1021/acs.est.6b03684 PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA EC5ED UT WOS:000388155000023 PM 27766831 ER PT J AU Noerpel, MR Lee, SS Lenhart, JJ AF Noerpel, Matthew R. Lee, Sang Soo Lenhart, John J. TI X-ray Analyses of Lead Adsorption on the (001), (110), and (012) Hematite Surfaces SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID INTERFACIAL WATER-STRUCTURE; CRYSTAL FACES; ABSORPTION SPECTROSCOPY; PB(II) SORPTION; HEAVY-METALS; IRON-OXIDES; SPECIATION; REACTIVITY; COMPLEXES; GOETHITE AB Predicting the environmental fate of lead relies on a detailed understanding of its coordination to mineral surfaces, which in turn reflects the innate reactivity of the mineral surface. In this research, we investigated fundamental dependencies in lead, adsorption to hematite by coupling extended X-ray absorption fine structure (EXAFS) spectroscopy on hematite particles (10 and 50 nm) with resonant anomalous X-ray reflectivity (RAXR) to single crystals expressing the (001), (012), or (110) crystallographic face. The EXAFS showed that lead adsorbed in a bidentate inner-sphere manner in both edge and corner sharing arrangements on the FeO6 octahedra for both particle sizes. The RAXR measurements confirmed these inner-sphere adsorption modes for all three hematite surfaces and additionally revealed outer-sphere adsorption modes not seen in the EXAFS. Lead uptake was larger and pH dependence was greater for the (012) and (110) surfaces, than the (001) surface, due to their expressing singly- and triply coordinated oxygen atoms the (001) surface lacks. In coupling these two techniques we provide a more detailed and nuanced picture of the coordination of lead to hematite while also providing fundamental insight into the reactivity of hematite. C1 [Noerpel, Matthew R.; Lenhart, John J.] Ohio State Univ, Dept Civil Environm & Geodet Engn, Columbus, OH 43210 USA. [Lee, Sang Soo] Argonne Natl Lab, Chem Sci & Engn Div, 9700 South Cass Ave, Argonne, IL 60439 USA. [Noerpel, Matthew R.] US EPA, 5995 Ctr Hill Ave, Cincinnati, OH 45224 USA. RP Lenhart, JJ (reprint author), Ohio State Univ, Dept Civil Environm & Geodet Engn, Columbus, OH 43210 USA. EM lenhart.49@osu.edu FU U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, Chemical Sciences, Geosciences, and Biosciences Division [DE-AC02-06CH11357]; National Science Foundation [0954991]; DOE Office of Science [DE-AC02-06CH11357]; Canadian Light Source FX This work was supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, Chemical Sciences, Geosciences, and Biosciences Division under Contract DE-AC02-06CH11357 to UChicago Argonne, LLC as operator of Argonne National Laboratory (for S.S.L.) and by the National Science Foundation under Grant No. 0954991. All X-ray work was performed at the Advanced Photon Source, sectors 6, 20, and 33. This research used resources of the Advanced Photon Source, a U.S. Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under Contract No. DE-AC02-06CH11357. Sector 20 is also jointly supported by the Canadian Light Source. We would also like to thank the associate editor and five anonymous reviewers for their comments which greatly improved the quality of this manuscript. NR 53 TC 0 Z9 0 U1 17 U2 17 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD NOV 15 PY 2016 VL 50 IS 22 BP 12283 EP 12291 DI 10.1021/acs.est.6b03913 PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA EC5ED UT WOS:000388155000026 PM 27767293 ER PT J AU Scheffe, RD Strum, M Phillips, SB Thurman, J Eyth, A Fudge, S Morris, M Palma, T Cook, R AF Scheffe, Richard D. Strum, Madeleine Phillips, Sharon B. Thurman, James Eyth, Alison Fudge, Steve Morris, Mark Palma, Ted Cook, Richard TI Hybrid Modeling Approach to Estimate Exposures of Hazardous Air Pollutants (HAPs) for the National Air Toxics Assessment (NATA) SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID PATH-INTEGRAL METHOD; SOURCE APPORTIONMENT; QUALITY; CMAQ; FORMALDEHYDE; EMISSIONS; IMPACTS; DETROIT; SYSTEM; OZONE AB A hybrid air quality model has been developed and applied to estimate annual concentrations of 40 hazardous air pollutants (HAPs) across the continental United States (CONUS) to support the 2011 calendar year National Air Toxics Assessment (NATA). By combining a chemical transport model (CTM) with a Gaussian dispersion model, both reactive and nonreactive HAPs are accommodated across local to regional spatial scales, through a multiplicative technique designed to improve mass conservation relative to previous additive methods. The broad scope of multiple pollutants capturing regional to local spatial scale patterns across a vast spatial domain is precedent setting within the air toxics community. The hybrid design exhibits improved performance relative to the stand alone CTM and dispersion model. However, model performance varies widely across pollutant categories and quantifiably definitive performance assessments are hampered by a limited observation base and challenged by the multiple physical and chemical attributes of HAPs. Formaldehyde and acetaldehyde are the dominant HAP concentration and cancer risk drivers, characterized by strong regional signals associated with naturally emitted carbonyl precursors enhanced in urban transport corridors with strong mobile source sector emissions. The multiple pollutant emission characteristics of combustion dominated source sectors creates largely similar concentration patterns across the majority of HAPs. However, reactive carbonyls exhibit significantly less spatial variability relative to nonreactive HAPs across the CONUS. C1 [Scheffe, Richard D.; Strum, Madeleine; Phillips, Sharon B.; Thurman, James; Eyth, Alison; Morris, Mark; Palma, Ted] US EPA, Off Air Qual Planning & Stand, Durham, NC 27711 USA. [Fudge, Steve] EC R Inc, Chapel Hill, NC 27514 USA. [Cook, Richard] US EPA, Off Transportat & Air Qual, Ann Arbor, MI 48105 USA. RP Scheffe, RD (reprint author), US EPA, Off Air Qual Planning & Stand, Durham, NC 27711 USA. EM Scheffe.rich@epa.gov NR 39 TC 0 Z9 0 U1 5 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD NOV 15 PY 2016 VL 50 IS 22 BP 12356 EP 12364 DI 10.1021/acs.est.6b04752 PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA EC5ED UT WOS:000388155000034 PM 27779870 ER PT J AU Peng, Y Xia, P Zhang, JJ Villeneuve, DL Zhang, JM Wang, ZH Wei, S Yu, HX Zhang, XW AF Peng, Ying Xia, Pu Zhang, Junjiang Villeneuve, Daniel L. Zhang, Jiamin Wang, Zhihao Wei, Si Yu, Hongxia Zhang, Xiaowei TI Toxicogenomic Assessment of 6-OH-BDE47-Induced Developmental Toxicity in Chicken Embryos SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID POLYBROMINATED DIPHENYL ETHERS; BROMINATED FLAME RETARDANTS; IN-VITRO; OH-PBDES; OXIDATIVE-PHOSPHORYLATION; NATURAL-PRODUCTS; JAPANESE-QUAIL; IDENTIFICATION; ENVIRONMENT; INDUCTION AB Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) are analogs of PBDEs with hundreds of possible structures and are frequently detected in the environment. However, the in vivo evidence on the toxicity of OH-PBDEs is still very limited. Here, the developmental toxicity of 6-OH-BDE47, a predominant congener of OH-PBDEs detected in the environment, in chicken embryos was assessed using a toxicogenomic approach. Fertilized chicken eggs were dosed via in ovo administration of 0.006 to 0.474 nmol 6-OH-BDE47/g egg followed by 18 days of incubation. Significant embryo lethality (LD50 = 1.940 nmol/g egg) and increased hepatic somatic index (HSI) were caused by 6-OH-BDE47 exposure: The functional enrichment of differentially expressed genes (DEGs) was associated with oxidative phosphorylation, generation of precursor metabolites and energy, and electron transport chains, which suggest that 6-OH-BDE47 exposure may disrupt the embryo development by altering the function of energy production in mitochondria. Moreover, aryl hydrocarbon receptor (AhR)-mediated responses including up-regulation of CYP1A4 were observed in the livers of embryos exposed to 6-OH-BDE47. Overall, this study confirmed the embryo lethality by 6-OH-BDE47 and further improved the mechanistic understanding of OH-PBDEs-caused toxicity. Ecological risk assessment via application of both no-observed-effect level (NOEL) and the sensitive NOTEL (transcriptional NOEL) suggested that OH-PBDEs might cause ecological risk to wild birds. C1 [Peng, Ying; Xia, Pu; Zhang, Junjiang; Zhang, Jiamin; Wang, Zhihao; Wei, Si; Yu, Hongxia; Zhang, Xiaowei] Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Jiangsu, Peoples R China. [Villeneuve, Daniel L.] US EPA, Mid Continent Ecol Div, Duluth, MN 55804 USA. RP Zhang, XW (reprint author), Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Jiangsu, Peoples R China. EM howard50003250@yahoo.com FU National Natural Science Foundation of China [21322704, 21677072]; Jiangsu Province Funds for Distinguished Young Scientists [BK20130015]; Fundamental Research Funds for the Central Universities; Collaborative Innovation Center for Regional Environmental Quality FX For support, we thank National Natural Science Foundation of China (grant nos. 21322704 and 21677072) and Jiangsu Province Funds for Distinguished Young Scientists (BK20130015). X.Z. was supported by the Fundamental Research Funds for the Central Universities and the Collaborative Innovation Center for Regional Environmental Quality. Although one of the authors is an employee of the United States Environmental Protection Agency (U.S. EPA), the contents of this manuscript neither represent nor necessarily reflect U.S. EPA policy. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 63 TC 0 Z9 0 U1 11 U2 11 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD NOV 15 PY 2016 VL 50 IS 22 BP 12493 EP 12503 DI 10.1021/acs.est.6b04467 PG 11 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA EC5ED UT WOS:000388155000049 PM 27749045 ER PT J AU Croft, B Wentworth, GR Martin, RV Leaitch, WR Murphy, JG Murphy, BN Kodros, JK Abbatt, JPD Pierce, JR AF Croft, B. Wentworth, G. R. Martin, R. V. Leaitch, W. R. Murphy, J. G. Murphy, B. N. Kodros, J. K. Abbatt, J. P. D. Pierce, J. R. TI Contribution of Arctic seabird-colony ammonia to atmospheric particles and cloud-albedo radiative effect SO NATURE COMMUNICATIONS LA English DT Article ID SULFURIC-ACID; OXIDATION-PRODUCTS; WET DEPOSITION; BLACK CARBON; AEROSOL; EMISSIONS; NUCLEATION; MODEL; SUMMER; TRANSPORT AB The Arctic region is vulnerable to climate change and able to affect global climate. The summertime Arctic atmosphere is pristine and strongly influenced by natural regional emissions, which have poorly understood climate impacts related to atmospheric particles and clouds. Here we show that ammonia from seabird-colony guano is a key factor contributing to bursts of newly formed particles, which are observed every summer in the near-surface atmosphere at Alert, Nunavut, Canada. Our chemical-transport model simulations indicate that the pan-Arctic seabird-influenced particles can grow by sulfuric acid and organic vapour condensation to diameters sufficiently large to promote pan-Arctic cloud-droplet formation in the clean Arctic summertime. We calculate that the resultant cooling tendencies could be large (about -0.5Wm(-2) pan-Arctic-mean cooling), exceeding -1Wm(-2) near the largest seabird colonies due to the effects of seabird-influenced particles on cloud albedo. These coupled ecological-chemical processes may be susceptible to Arctic warming and industrialization. C1 [Croft, B.; Martin, R. V.; Pierce, J. R.] Dalhousie Univ, Dept Phys & Atmospher Sci, 6310 Coburg Rd, Halifax, NS B3H 4R2, Canada. [Wentworth, G. R.; Murphy, J. G.; Abbatt, J. P. D.] Univ Toronto, Dept Chem, 80 St George St, Toronto, ON M5S 3H6, Canada. [Martin, R. V.] Harvard Smithsonian Ctr Astrophys, 60 Garden St, Cambridge, MA 02138 USA. [Leaitch, W. R.] Environm & Climate Change Canada, Div Climate Res, 4905 Dufferin St, Toronto, ON M3H 5T4, Canada. [Murphy, B. N.] Stockholm Univ, Dept Environm Sci & Analyt Chem ACES, Svante Arrhenius Vag 8, SE-11418 Stockholm, Sweden. [Murphy, B. N.] Stockholm Univ, Bolin Ctr Climate Res, Svante Arrhenius Vag 8, SE-11418 Stockholm, Sweden. [Kodros, J. K.; Pierce, J. R.] Colorado State Univ, Dept Atmospher Sci, 3915W Laporte, Ft Collins, CO 80523 USA. [Murphy, B. N.] US EPA, Computat Exposure Div, 200 Pk Dr, Res Triangle Pk, NC 27709 USA. [Wentworth, G. R.] Alberta Environm & Pk, Environm Monitoring & Sci Div, 9888 Jasper Ave NW, Edmonton, AB T5J 5C6, Canada. RP Croft, B (reprint author), Dalhousie Univ, Dept Phys & Atmospher Sci, 6310 Coburg Rd, Halifax, NS B3H 4R2, Canada.; Wentworth, GR (reprint author), Univ Toronto, Dept Chem, 80 St George St, Toronto, ON M5S 3H6, Canada.; Wentworth, GR (reprint author), Alberta Environm & Pk, Environm Monitoring & Sci Div, 9888 Jasper Ave NW, Edmonton, AB T5J 5C6, Canada. EM betty.croft@dal.ca; greg.wentworth@gov.ab.ca RI Murphy, Jennifer/C-2367-2011; Pierce, Jeffrey/E-4681-2013 OI Pierce, Jeffrey/0000-0002-4241-838X FU Climate Change and Atmospheric Research programme at NSERC; Environment and Climate Change (ECCC) aerosol programme at Alert FX NETCARE is supported by the Climate Change and Atmospheric Research programme at NSERC. We thank O. Kupiainen-Maatta, T. Olenius, J. Julin, H. Vehkamaki and I. Riipinen for their support of this project through constructive discussions, suggestions and provision of the Atmospheric Cluster Dynamics Code (ACDC). We thank Sangeeta Sharma, Desiree Toom, Alina Chivulescu, Dan Veber, the Observatory operators at Alert, Andrew Platt and Carrie Taylor for their support of the Environment and Climate Change (ECCC) aerosol programme at Alert. We thank Kevin Rawlings (www.krawlings.com) for the provision of his photographic image of two Arctic terns on tundra. Our sincere thanks are also extended to Kathy Kuletz of the U.S. Fish and Wildlife Service for her helpful discussions regarding Arctic seabirds. We are grateful for the hard work and dedication of the CCGS Amundsen crew. We also thank Maurice Levasseur, Emma Mungall, Alex Lee, Vickie Irish, Heather Stark and Jeremy Wentzell for help with the Amundsen measurements, for example, during mobilization, demobilization and calibration of the AIM-IC. NR 80 TC 0 Z9 0 U1 18 U2 18 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2041-1723 J9 NAT COMMUN JI Nat. Commun. PD NOV 15 PY 2016 VL 7 AR 13444 DI 10.1038/ncomms13444 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EC2RV UT WOS:000387972500001 PM 27845764 ER PT J AU Knudsen, GA Hughes, MF Sanders, JM Hall, SM Birnbaum, LS AF Knudsen, Gabriel A. Hughes, Michael F. Sanders, J. Michael Hall, Samantha M. Birnbaum, Linda S. TI Estimation of human percutaneous bioavailability for two novel brominated flame retardants, 2-ethylhexyl 2,3,4,5-tetrabromobenzoate (EH-TBB) and bis(2-ethylhexyl) tetrabromophthalate (BEH-TEBP) SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article DE Dermal bioavailability; Brominated flame retardant; 2-Ethylhexyl 2-3,4,5-tetrabromobenzoate; Bis(2-ethylhexyl) tetrabromophthalate; Parallelogram method; Persistent organic pollutant ID IN-HOUSE DUST; ENDOCRINE DISRUPTING CHEMICALS; POLYBROMINATED DIPHENYL ETHERS; MIXTURE FIREMASTER(R) 550; VITRO DERMAL ABSORPTION; GREAT-LAKES ATMOSPHERE; RAT SKIN ABSORPTION; EARLY-LIFE EXPOSURE; INDOOR DUST; PARALLELOGRAM METHOD AB 2-Ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB) and bis(2-ethylhexyl)tetrabromophthalate (BEH-TEBP) are novel brominated flame retardants used in consumer products. A parallelogram approach was used to predict human dermal absorption and flux for EH-TBB and BEH-TEBP. [C-14]-EH-TBB or [C-14]-BEH-TEBP was applied to human or rat skin at 100 nmol/cm(2) using a flow-through system. Intact rats received analogous dermal doses. Treated skin was washed and tape-stripped to remove "unabsorbed" [C-14]-radioactivity after continuous exposure (24 h). "Absorbed" was quantified using dermally retained [C-14]-radioactivity; "penetrated" was calculated based on [C-14]-radioactivity in media (in vitro) or excreta + tissues (in vivo). Human skin absorbed EH-TBB (24 +/- 1%) while 0.2 +/- 0.1% penetrated skin. Rat skin absorbed more (51 +/- 10%) and was more permeable (2 +/- 0.5%) to EH-TBB in vitro; maximal EH-TBB flux was 11 +/- 7 and 102 +/- 24 pmol-eq/cm(2)/h for human and rat skin, respectively. In vivo, 27 +/- 5% was absorbed and 13% reached systemic circulation after 24 h (maximum flux was 464 +/- 65 pmol-eq/cm(2)/h). BEH-TEBP in vitro penetrance was minimal (<0.01%) for rat or human skin. BEH-TEBP absorption was 12 +/- 11% for human skin and 41 +/- 3% for rat skin. In vivo, total absorption was 27 +/- 9%; 12% reached systemic circulation. In vitro maximal BEH-TEBP flux was 0.3 +/- 0.2 and 1 +/- 0.3 pmol-eq/cm2/h for human and rat skin; in vivo maximum flux for rat skin was 16 +/- 7 pmol-eq/cm2/h. EH-TBB was metabolized in rat and human skin to tetrabromobenzoic acid. BEH-TEBP-derived [C-14] -radioactivity in the perfusion media could not be characterized. <1% of the dose of EH-TBB and BEH-TEHP is estimated to reach the systemic circulation following human dermal exposure under the conditions tested. Chemical compounds studied in this article: 2-Ethylhexyl 2,3,4,5-tetrabromobenzoate (PubChem CID: 71316600; CAS No. 183658-27-7 FW: 549.92 g/mol logP(est): 7.73-8.75 (12)) Abdallah et al., 2015a. Other published abbreviations for 2-ethylhexyl-2,3,4,5-tetrabromobenzoate are TBB EHTeBB or EHTBB Abdallah and Harrad, 2011. bis(2-ethylhexyl) tetrabromophthalate (PubChem CID: 117291; CAS No. 26040-51-7 FW: 706.14 g/mol logP(est): 9.48-11.95 (12)). Other published abbreviations for bis(2-ethylhexyl)tetrabromophthalate are TeBrDEPH TBPH or BEHTBP. Published by Elsevier Inc. C1 [Knudsen, Gabriel A.; Sanders, J. Michael; Hall, Samantha M.; Birnbaum, Linda S.] NCI, Lab Toxicol & Toxicokinet, 111 TW Alexander Dr, Res Triangle Pk, NC USA. [Hughes, Michael F.] US EPA, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. RP Knudsen, GA (reprint author), 111 TW Alexander Dr,BG 101 Rm C220A, Res Triangle Pk, NC 27709 USA. EM gabriel.knudsen@nih.gov OI Hall, Samantha M./0000-0003-1608-9508 FU Intramural Research Program of NIH/NCI [ZIA BC 011476] FX The authors would like to thank Ms. Brenda Edwards, Mr. Ethan Hull, Ms. Katelyn McIntosh and Mr. Vivek Miyani, for technical assistance. This article has been reviewed in accordance with the policy of the National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, and approved for publication. Approval does not signify that the contents necessarily reflect the views and policies of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. This research was supported in part by the Intramural Research Program of NIH/NCI (Project ZIA BC 011476). NR 96 TC 0 Z9 0 U1 7 U2 7 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0041-008X EI 1096-0333 J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD NOV 15 PY 2016 VL 311 BP 117 EP 127 DI 10.1016/j.taap.2016.10.005 PG 11 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA EA9VI UT WOS:000386992400013 PM 27732871 ER PT J AU Gassie, LW Englehardt, JD Wang, J Brinkman, N Garland, J Gardinali, P Guo, TJ AF Gassie, Lucien W. Englehardt, James D. Wang, Jian Brinkman, Nichole Garland, Jay Gardinali, Piero Guo, Tianjiao TI Mineralizing urban net-zero water treatment: Phase II field results and design recommendations SO WATER RESEARCH LA English DT Article DE Advanced oxidation; Potable water reuse; Net-zero ID CHEMICAL OXYGEN-DEMAND; WASTE-WATER; HYDROGEN-PEROXIDE; REMOVAL; REUSE; OPTIMIZATION; ENTEROVIRUS; ADENOVIRUS; NOROVIRUS; CHLORIDE AB Net-zero water (NZW) systems, or water management systems achieving high recycling rates and low residuals generation so as to avoid water import and export, can also conserve energy used to heat and convey water, while economically restoring local eco-hydrology. However, design and operating experience are extremely limited. The objective of this paper is to present the results of the second phase of operation of an advanced oxidation-based NZW pilot system designed, constructed, and operated for a period of two years, serving an occupied four-person, apartment. System water was monitored, either continuously or thrice daily, for routine water quality parameters, minerals, and MicroTox (R) in-vitro toxicity, and intermittently for somatic and male-specific coliphage, adenovirus, Cryptosporidium, Giardia, emerging organic constituents (non-quantitative), and the Florida drinking water standards. All 115 drinking water standards with the exception of bromate were met in this phase. Neither virus nor protozoa were detected in the treated water, with the exception of measurement of adenovirus genome copies attributed to accumulation of inactive genetic material in hydraulic dead zones: Chemical oxygen demand was mineralized to <0.7 mg/L, and all but six of 1006 emerging organic constituents analyzed were either undetected or removed >90% in treatment, Total dissolved solids were maintained at similar to 500 mg/L at steady state, partially through aerated aluminum electrocoagulation. Bromate accumulation is projected to be controlled by aluminum electrocoagulation with separate disposal of backwash water. Further development of such systems and their automated/remote process control systems is recommended. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Gassie, Lucien W.; Englehardt, James D.] Univ Miami, 1251 Mem Dr, Coral Gables, FL 33146 USA. [Wang, Jian; Gardinali, Piero] Florida Int Univ, 3000 NE 151th St, North Miami Beach, FL 33181 USA. [Brinkman, Nichole; Garland, Jay] US EPA, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. [Guo, Tianjiao] Mass Instruments LLC, 301 Reservoir St, Needham, MA 02494 USA. [Wang, Jian] Waters Corp, Cummings Ctr 100, Suite 407N, Beverly, MA 01915 USA. RP Englehardt, JD (reprint author), Univ Miami, 1251 Mem Dr, Coral Gables, FL 33146 USA. EM l.gassie@umiami.edu; jenglehardt@miami.edu; jian_J_Wang@waters.com; Brinkman.Nichole@epa.gov; Garland.Jay@epa.gov; Piero.Gardinali@fiu.edu; guotianjiao@massinstrumentsllc.com FU US National Science Foundation (EFRI-SEED) [1038257]; U.S. Environmental Protection Agency; University of Miami, Engineered Control Systems, Inc.; Bio-Microbics, Inc.; Wastewater Technologies, Inc.; Florida International University; Hazen and Sawyer; BK Precision Corp.; RTI Supply FX The support of the US National Science Foundation (EFRI-SEED Award 1038257), the U.S. Environmental Protection Agency, the University of Miami, Engineered Control Systems, Inc., Bio-Microbics, Inc., Wastewater Technologies, Inc., Florida International University, Hazen and Sawyer, BK Precision Corp., RTI Supply, and for this work is gratefully acknowledged. The authors would also like to thank Spartan Environmental Technologies for technical collaboration, and the numerous student research assistants for the help in system operation, sampling, analysis, and data processing. NR 31 TC 2 Z9 2 U1 17 U2 17 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0043-1354 J9 WATER RES JI Water Res. PD NOV 15 PY 2016 VL 105 BP 496 EP 506 DI 10.1016/j.watres.2016.09.005 PG 11 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA DZ5KW UT WOS:000385902000051 PM 27668994 ER PT J AU Wanjugi, P Sivaganesan, M Korajkic, A Kelty, CA McMinn, B Ulrich, R Harwood, VJ Shanks, OC AF Wanjugi, Pauline Sivaganesan, Mania Korajkic, Asja Kelty, Catherine A. McMinn, Brian Ulrich, Robert Harwood, Valerie J. Shanks, Orin C. TI Differential decomposition of bacterial and viral fecal indicators in common human pollution types SO WATER RESEARCH LA English DT Article DE Human fecal pollution; Coliphage; Fecal indicator bacteria; Microbial source tracking ID MICROBIAL SOURCE TRACKING; TIME QUANTITATIVE PCR; 16S RIBOSOMAL-RNA; ESCHERICHIA-COLI; GENETIC-MARKERS; SOURCE IDENTIFICATION; MISSISSIPPI RIVER; WATER; BACTEROIDES; PERFORMANCE AB Understanding the decomposition of microorganisms associated with different human fecal pollution types is necessary for proper implementation of many water quality management practices, as well as predicting associated public health risks. Here, the decomposition of select cultivated and molecular indicators of fecal pollution originating from fresh human feces, septage, and primary effluent sewage in a subtropical marine environment was assessed over a six day period with an emphasis on the influence of ambient sunlight and indigenous microbiota. Ambient water mixed with each fecal pollution type was placed in dialysis bags and incubated in situ in a submersible aquatic mesocosm. Genetic and cultivated fecal indicators including fecal indicator bacteria (enterococci, E. coli, and Bacteroidales), coliphage (somatic and F+), Bacteroides fragilis phage (GB-124), and human-associated genetic indicators (HF183/BacR287 and HumM2) were measured in each sample. Simple linear regression assessing treatment trends in each pollution type over time showed significant decay (p <= 0.05) in most treatments for feces and sewage (27/28 and 32/40, respectively), compared to septage (6/26). A two-way analysis of variance of logio reduction values for sewage and feces experiments indicated that treatments differentially impact survival of cultivated bacteria, cultivated phage, and genetic indicators. Findings suggest that sunlight is critical for phage decay, and indigenous microbiota play a lesser role. For bacterial cultivated and genetic indicators, the influence of indigenous microbiota varied by pollution type. This study offers new insights on the decomposition of common human fecal pollution types in a subtropical marine environment with important implications for water quality management applications. Published by Elsevier Ltd. C1 [Wanjugi, Pauline; Sivaganesan, Mania; Korajkic, Asja; Kelty, Catherine A.; McMinn, Brian; Shanks, Orin C.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. [Harwood, Valerie J.] Univ S Florida, Dept Integrat Biol, Tampa, FL 33620 USA. [Ulrich, Robert] Pure Mol LLC, St Petersburg, FL 33716 USA. RP Shanks, OC (reprint author), US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. EM shanks.orin@epa.gov NR 53 TC 0 Z9 0 U1 16 U2 16 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0043-1354 J9 WATER RES JI Water Res. PD NOV 15 PY 2016 VL 105 BP 591 EP 601 DI 10.1016/j.watres.2016.09.041 PG 11 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA DZ5KW UT WOS:000385902000061 PM 27693971 ER PT J AU Wu, JY Jackson, L AF Wu, Jianyong Jackson, Laura TI Association of land use and its change with beach closure in the United States, 2004-2013 SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Beach water quality; Land cover; land use change; Urbanization; Ecosystem health ID MICROBIAL SOURCE TRACKING; FECAL INDICATOR BACTERIA; WATER-QUALITY; ESCHERICHIA-COLI; RECREATIONAL WATER; LAKE-MICHIGAN; HEALTH; ILLNESS; POLLUTION; MARINE AB Land use and its change have great influences on water quality. However, their impacts on microbial contamination of beach water have rarely been investigated and their relationship with beach actions (e.g., advisories or closure) is still unknown. Here, we analyzed beach closure data obtained from 2004 to 2013 for >500 beaches in the United States, and examined their associations with land use around beaches in 2006 and 2011, as well as the land use change between 2006 and 2011. The results show that the number of beach closures due to elevated indicators of health risk is negatively associated with the percentages of forest, barren land, grassland and wetland, while positively associated with the percentages of urban area. The results from multi-level models also indicate the negative association with forest area but positive association with urban area and agriculture. The examination of the change of land use and the number of beach closures between 2006 and 2011 indicates that the increase in the number of beach closures is positively associated with the increase in urban (beta = 1.612, p < 0.05) and agricultural area including pasture (beta = 0.098, p < 0.05), but negatively associated with the increase in forest area (beta = -1.789, p < 0.05). The study suggests that urbanization and agriculture development near beaches have adverse effects on beach microbial water quality, while afforestation may protect beach water quality and reduce the number of beach closures. (C) 2016 Elsevier B.V. All rights reserved. C1 [Wu, Jianyong] US EPA, Off Res & Dev, Durham, NC 27711 USA. [Jackson, Laura] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Durham, NC 27711 USA. RP Wu, JY (reprint author), 109 TW Alexander Driver, Durham, NC 27711 USA. EM wu.jianyong@epa.gov; Jackson.Laura@epa.gov RI Wu, Jianyong/A-6854-2011 OI Wu, Jianyong/0000-0002-5864-3186 NR 62 TC 0 Z9 0 U1 40 U2 40 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD NOV 15 PY 2016 VL 571 BP 67 EP 76 DI 10.1016/j.scitotenv.2016.07.116 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA DW8UG UT WOS:000383930400009 PM 27459255 ER PT J AU Brown, MT Campbell, DE Franzese, PP Ulgiati, S AF Brown, Mark T. Campbell, Daniel E. Franzese, Pier Paolo Ulgiati, Sergio TI The geobiosphere emergy baseline: A synthesis SO ECOLOGICAL MODELLING LA English DT Editorial Material ID ECOSYSTEM SERVICES; URBAN-DEVELOPMENT; CHINA; SYSTEMS; ENERGY; PERSPECTIVE; MECHANISMS; IMPACTS; CYCLES; FOREST C1 [Brown, Mark T.] Univ Florida, Phelps Lab, Ctr Environm Policy, Gainesville, FL 32611 USA. [Campbell, Daniel E.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA. [Franzese, Pier Paolo; Ulgiati, Sergio] Parthenope Univ Naples, Dept Sci & Technol, Ctr Direz, Isola C4, I-80143 Naples, Italy. RP Brown, MT (reprint author), Univ Florida, Phelps Lab, Ctr Environm Policy, Gainesville, FL 32611 USA. EM mtb@ufl.edu; campbell.dan@epa.gov; pierpaolo.franzese@uniparthenope.it; sergio.ulgiati@uniparthenope.it NR 39 TC 0 Z9 0 U1 11 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3800 EI 1872-7026 J9 ECOL MODEL JI Ecol. Model. PD NOV 10 PY 2016 VL 339 SI SI BP 89 EP 91 DI 10.1016/j.ecolmodel.2016.09.009 PG 3 WC Ecology SC Environmental Sciences & Ecology GA DY1RB UT WOS:000384871000009 ER PT J AU Brown, MT Campbell, DE De Vilbiss, C Ulgiati, S AF Brown, Mark T. Campbell, Daniel E. De Vilbiss, Christopher Ulgiati, Sergio TI The geobiosphere emergy baseline: A synthesis SO ECOLOGICAL MODELLING LA English DT Article DE Geobiosphere emergy baseline; Solar equivalence ratio; Solar equivalent exergy AB The concept of emergy defined as the available energy (or exergy) of one form used up directly and indirectly to produce an item or action (Odum, Environmental Accounting Emergy and Environmental Decision Making, John Wiley & Sons, Inc., 1996) requires the specification of a uniform solar equivalent exergy reference, or geobiosphere emergy baseline (GEB). Three primary exergy sources of different origins interact to drive processes within the geobiosphere. Each of these sources are expressed in solar equivalent exergy from which, all other forms of energy can be computed, so that they may be expressed as emergy in units of solar emjoules. If emergy practitioners reference their work to a single agreed upon baseline, then all research products resulting from the application of the emergy approach will be inherently consistent and valid comparisons can then be made easily. In this paper, we synthesize information from three new calculation procedures of the emergy baseline for the geobiosphere and propose a unified solution. (C) 2016 Elsevier B.V. All rights reserved. C1 [Brown, Mark T.; De Vilbiss, Christopher] Univ Florida, Gainesville, FL USA. [Campbell, Daniel E.] US EPA, ORD, NHEERL, AED, Narragansett, RI USA. [Ulgiati, Sergio] Parthenope Univ Naples, Naples, Italy. [Ulgiati, Sergio] Beijing Normal Univ, Sch Environm, Beijing, Peoples R China. RP Brown, MT (reprint author), Univ Florida, Gainesville, FL USA. NR 20 TC 7 Z9 7 U1 6 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3800 EI 1872-7026 J9 ECOL MODEL JI Ecol. Model. PD NOV 10 PY 2016 VL 339 SI SI BP 92 EP 95 DI 10.1016/j.ecolodel.2016.03.018 PG 4 WC Ecology SC Environmental Sciences & Ecology GA DY1RB UT WOS:000384871000010 ER PT J AU Campbell, DE AF Campbell, Daniel E. TI Emergy baseline for the Earth: A historical review of the science and a new calculation SO ECOLOGICAL MODELLING LA English DT Article DE Planetary emergy baseline; Emergy evaluation; Solar exergy; Tidal geopotential energy; Deep Earth heat flow ID MOON TIDAL EVOLUTION; HEAT-FLOW; HYDROTHERMAL CIRCULATION; CONTINENTAL-CRUST; OCEAN; ENERGY; DISSIPATION; MODEL; RIDGE; FLUX AB Quantifying the emergy baseline of the Earth is a practical necessity for emergy evaluations, because it serves as a unified basis for determining transformities of the available energy storages and flows of the geobiosphere. The current debate over the value and significance of the planetary baseline has been in progress since 1998, when the author first brought new data on geopotential energy formation in the world oceans to H.T. Odum's attention. In this paper, past studies of the baseline were reviewed and errors in data translation and model formulation were found to be sufficient to justify a new calculation. A fundamental epistemological obstacle to establishing a unified planetary baseline (i.e., the production functions for deep Earth heat and tide as a function of solar radiation are unknown) is overcome by using the transitive property of equalities to estimate equivalences between solar radiation and Earth's deep heat exergy flows (4200 solar equivalent joules per joule, seJ J(-1)) and between the exergy of solar radiation and the tidal exergy dissipated in the oceans (35,400 seJ J(-1)). At present, the planetary baseline for the Earth with its ice-covered, polar oceans is approximately 1.16 x 10(25) seJ y(-1) and the distribution of the emergy or the organizing power of the inputs is: 1/3 solar radiation, 1/3 deep Earth heat and 1/3 tidal geopotential energy. In addition, the planetary baseline has been remarkably stable over the past 555,000,000y (1.00 x 10(25) +/- 1.13 x 10(24) seJ y(-1) or within +/- 11%). The tidal exergy dissipated in the world oceans over this time varies from 31% to 155% of its present value largely due to the changing efficiency of the Earth as a "machine" for generating tidal exergy. Close correspondence of the value and properties of this new baseline with the principles of Energy Systems Theory indicates that it should be preferred over prior determinations. Published by Elsevier B.V. C1 [Campbell, Daniel E.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA. RP Campbell, DE (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA. EM campbell.dan@epa.gov NR 99 TC 5 Z9 5 U1 10 U2 10 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3800 EI 1872-7026 J9 ECOL MODEL JI Ecol. Model. PD NOV 10 PY 2016 VL 339 SI SI BP 96 EP 125 DI 10.1016/j.ecolmodel.2015.12.010 PG 30 WC Ecology SC Environmental Sciences & Ecology GA DY1RB UT WOS:000384871000011 ER PT J AU Zheng, XF Yang, PY Lackford, B Bennett, BD Wang, L Li, H Wang, Y Miao, YL Foley, JF Fargo, DC Jin, Y Williams, CJ Jothi, R Hu, G AF Zheng, Xiaofeng Yang, Pengyi Lackford, Brad Bennett, Brian D. Wang, Li Li, Hui Wang, Yu Miao, Yiliang Foley, Julie F. Fargo, David C. Jin, Ying Williams, Carmen J. Jothi, Raja Hu, Guang TI CNOT3-Dependent mRNA Deadenylation Safeguards the Pluripotent State SO STEM CELL REPORTS LA English DT Article ID EMBRYONIC STEM-CELLS; CCR4-NOT COMPLEX; SELF-RENEWAL; FACILITATES PLURIPOTENCY; IN-VIVO; PROTEINS; GENOME; CNOT3; DIFFERENTIATION; IDENTIFICATION AB Poly(A) tail length and mRNA deadenylation play important roles in gene regulation. However, how they regulate embryonic development and pluripotent cell fate is not fully understood. Here we present evidence that CNOT3-dependent mRNA deadenylation governs the pluripotent state. We show that CNOT3, a component of the Ccr4-Not deadenylase complex, is required for mouse epiblast maintenance. It is highly expressed in blastocysts and its deletion leads to peri-implantation lethality. The epiblast cells in Cnot3 deletion embryos are quickly lost during diapause and fail to outgrow in culture. Mechanistically, CNOT3 C terminus is required for its interaction with the complex and its function in embryonic stem cells (ESCs). Furthermore, Cnot3 deletion results in increases in the poly(A) tail lengths, half-lives, and steady-state levels of differentiation gene mRNAs. The half-lives of CNOT3 target mRNAs are shorter in ESCs and become longer during normal differentiation. Together, we propose that CNOT3 maintains the pluripotent state by promoting differentiation gene mRNA deadenylation and degradation, and we identify poly(A) tail-length regulation as a post-transcriptional mechanism that controls pluripotency. C1 [Zheng, Xiaofeng; Yang, Pengyi; Lackford, Brad; Wang, Li; Jothi, Raja; Hu, Guang] Natl Inst Environm Hlth Sci, Epigenet & Stem Cell Biol Lab, Res Triangle Pk, NC 27709 USA. [Bennett, Brian D.; Fargo, David C.] Natl Inst Environm Hlth Sci, Integrat Bioinformat Support Grp, Res Triangle Pk, NC 27709 USA. [Li, Hui; Jin, Ying] Shanghai Jiao Tong Univ, Lab Mol Dev Biol, Sch Med, Shanghai 200025, Peoples R China. [Wang, Yu; Foley, Julie F.] Natl Inst Environm Hlth Sci, Cellular & Mol Pathol Branch, Res Triangle Pk, NC 27709 USA. [Miao, Yiliang; Williams, Carmen J.] Natl Inst Environm Hlth Sci, Reprod & Dev Biol Lab, Res Triangle Pk, NC 27709 USA. RP Hu, G (reprint author), Natl Inst Environm Hlth Sci, Epigenet & Stem Cell Biol Lab, Res Triangle Pk, NC 27709 USA. EM hug4@niehs.nih.gov OI Yang, Pengyi/0000-0003-1098-3138 FU Intramural Research Program of the NIH, National Institute of Environmental Health Sciences [Z01ES102745, Z01ES102985, Z01ES102625] FX We thank Dr. Anna-Katerina Hadjantonakis for helpful discussions. We thank the NIEHS Animal, Epigenomics, Bioinformatics, Protein Expression, Imaging, and Histology core facility for assistance with various techniques and experiments. This study was supported in part by the Intramural Research Program of the NIH, National Institute of Environmental Health Sciences Z01ES102745 (to G.H.), Z01ES102985 (to C.J.W.), and Z01ES102625 (to R.J.). NR 56 TC 0 Z9 0 U1 0 U2 0 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 2213-6711 J9 STEM CELL REP JI Stem Cell Rep. PD NOV 8 PY 2016 VL 7 IS 5 BP 897 EP 910 DI 10.1016/j.stemcr.2016.09.007 PG 14 WC Cell & Tissue Engineering; Cell Biology SC Cell Biology GA EE3QH UT WOS:000389509000007 PM 27746116 ER PT J AU Liu, JQ Chen, HY Yao, LD Wei, ZY Lou, LP Shan, YG Endalkachew, SD Mallikarjuna, N Hu, BL Zhou, XY AF Liu, Jingqing Chen, Huanyu Yao, Lingdan Wei, Zongyuan Lou, Liping Shan, Yonggui Endalkachew, Sahle-Demessie Mallikarjuna, Nadagouda Hu, Baolan Zhou, Xiaoyan TI The spatial distribution of pollutants in pipe-scale of large-diameter pipelines in a drinking water distribution system SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE Pipe-scale; Drinking water distribution system; Heavy metals; Organic deposit ID CAST-IRON PIPES; LOOSE DEPOSITS; BULK WATER; CORROSION; BIOFILMS; DISINFECTION; ACCUMULATION; RELEASE; COMMUNITIES; PARTICLES AB In large-diameter drinking water pipelines, spatial differences in hydraulic and physiochemical conditions may also result in spatial variations in pipe corrosion, biofilm growth and pollutant accumulation. In this article, the spatial distributions of various metals and organic contaminants in two 19-year-old grey cast iron pipes which had an internal diameter of 600 mm (DN600), were investigated and analyzed by Atomic Absorption Spectrometry, Gas Chromatography Mass Spectrometry, Energy Dispersive Spectrometer, X-ray Diffraction, etc. The spatial distribution of heavy metals varied significantly across the pipe section, and iron, manganese, lead, copper, and chromium were highest in concentration in the upper portion pipe-scales. However, the highest aluminum and zinc content was detected in the lower portion pipe-scales. Apart from some common types of hydrocarbons formed by microbial metabolites, there were also some microalgae metabolites and exogenous contaminants accumulated in pipe-scale, which also exhibited high diversity between different spatial locations. The spatial distributions of the physical and chemical properties of pipe-scale and contaminants were quite different in large-diameter pipes. The finding put forward higher requirements on the research method about drinking water distribution system chemical safety. And the scientific community need understand trend and dynamics of drinking water pipe systems better. (C) 2016 Elsevier B.V. All rights reserved. C1 [Liu, Jingqing] Zhejiang Univ, Coll Engn & Architecture, Hangzhou 310058, Zhejiang, Peoples R China. [Chen, Huanyu; Yao, Lingdan; Wei, Zongyuan; Lou, Liping; Hu, Baolan] Zhejiang Univ, Coll Environm & Resource Sci, Hangzhou 310058, Zhejiang, Peoples R China. [Shan, Yonggui; Endalkachew, Sahle-Demessie; Mallikarjuna, Nadagouda] NRMRL, Environm Protect Agcy, Off Res & Dev, Cincinnati, OH 45220 USA. [Zhou, Xiaoyan] Shaoxing Water Environm Sci Inst Co Ltd, Shaoxing 312000, Zhejiang, Peoples R China. [Chen, Huanyu] Zhejiang Univ, Binhai Ind Technol Res Inst, Tianjin 300000, Peoples R China. RP Lou, LP (reprint author), Zhejiang Univ, Coll Environm & Resource Sci, Hangzhou 310058, Zhejiang, Peoples R China. EM loulp@zju.edu.cn FU Key Special Program on the S&T Pollution Control and Treatment of Water Bodies [2012ZX07403-003]; National Key Technology RD Program [2012BAJ25B07] FX The authors thank the Key Special Program on the S&T Pollution Control and Treatment of Water Bodies (No. 2012ZX07403-003), the National Key Technology R&D Program (No. 2012BAJ25B07) and the National Natural Science Foundation of China (No. 51378455). NR 36 TC 1 Z9 1 U1 42 U2 42 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 EI 1873-3336 J9 J HAZARD MATER JI J. Hazard. Mater. PD NOV 5 PY 2016 VL 317 BP 27 EP 35 DI 10.1016/j.jhazmat.2016.05.048 PG 9 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA DT5OV UT WOS:000381533400004 PM 27244696 ER PT J AU Thomas, DJ Bradham, K AF Thomas, David J. Bradham, Karen TI Role of complex organic arsenicals in food in aggregate exposure to arsenic SO JOURNAL OF ENVIRONMENTAL SCIENCES LA English DT Review DE Arsenic; Arsenobetaine; Arsenolipids; Arsenosugars ID VITRO TOXICOLOGICAL CHARACTERIZATION; PERFORMANCE LIQUID-CHROMATOGRAPHY; THIO-DIMETHYLARSINIC ACID; PLASMA-MASS SPECTROMETRY; KELP ECKLONIA-RADIATA; ALGA FUCUS-GARDNERI; CONTAINING HYDROCARBONS; DRINKING-WATER; HUMAN URINE; PRESYSTEMIC METABOLISM AB For much of the world's population, food is the major source of exposure to arsenic. Exposure to this non-essential metalloid at relatively low levels may be linked to a wide range of adverse health effects. Thus, evaluating foods as sources of exposure to arsenic is important in assessing risk and developing strategies that protect public health. Although most emphasis has been placed on inorganic arsenic as human carcinogen and toxicant, an array of arsenic-containing species are found in plants and animals used as foods. Here, we 2evaluate the contribution of complex organic arsenicals (arsenosugars, arsenolipids, and trimethylarsonium compounds) that are found in foods and consider their origins, metabolism, and potential toxicity. Commonalities in the metabolism of arsenosugars and arsenolipids lead to the production of di-methylated arsenicals which are known to exert many toxic effects. Evaluating foods as sources of exposure to these complex organic arsenicals and understanding the formation of reactive metabolites may be critical in assessing their contribution to aggregate exposure to arsenic. (C) 2016 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V. C1 [Thomas, David J.] US EPA, Pharmacokinet Branch, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, Res Triangle Pk, NC 27709 USA. [Bradham, Karen] US EPA, Publ Hlth Chem Branch, Exposure Methods & Measurements Div, Natl Exposure Res Lab,Off Res & Dev, Res Triangle Pk, NC 27709 USA. RP Thomas, DJ (reprint author), US EPA, Pharmacokinet Branch, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, Res Triangle Pk, NC 27709 USA. EM thomas.david@epa.gov NR 120 TC 4 Z9 4 U1 7 U2 7 PU SCIENCE PRESS PI BEIJING PA 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA SN 1001-0742 EI 1878-7320 J9 J ENVIRON SCI-CHINA JI J. Environ. Sci. PD NOV 1 PY 2016 VL 49 BP 86 EP 96 DI 10.1016/j.jes.2016.06.005 PG 11 WC Environmental Sciences SC Environmental Sciences & Ecology GA EI3KT UT WOS:000392390300007 PM 28007183 ER PT J AU Moseman-Valtierra, S Abdul-Aziz, OI Tang, JW Ishtiaq, KS Morkeski, K Mora, J Quinn, RK Martin, RM Egan, K Brannon, EQ Carey, J Kroeger, KD AF Moseman-Valtierra, Serena Abdul-Aziz, Omar I. Tang, Jianwu Ishtiaq, Khandker S. Morkeski, Kate Mora, Jordan Quinn, Ryan K. Martin, Rose M. Egan, Katharine Brannon, Elizabeth Q. Carey, Joanna Kroeger, Kevin D. TI Carbon dioxide fluxes reflect plant zonation and belowground biomass in a coastal marsh SO ECOSPHERE LA English DT Article DE biological invasion; blue carbon; emissions; global climate changes; Juncus gerardii; methane; nitrous oxide; sea-level rise; Spartina alterniflora ID AUSTRALIS COMMON REED; RADIAL OXYGEN LOSS; PHRAGMITES-AUSTRALIS; SPARTINA-ALTERNIFLORA; METHANE EMISSION; NITROGEN LOADS; NEW-ENGLAND; SALT-MARSH; SALINITY GRADIENT; SOIL RESPIRATION AB Coastal wetlands are major global carbon sinks; however, they are heterogeneous and dynamic ecosystems. To characterize spatial and temporal variability in a New England salt marsh, greenhouse gas (GHG) fluxes were compared among major plant-defined zones during growing seasons. Carbon dioxide (CO2) and methane (CH4) fluxes were compared in two mensurative experiments during summer months (2012-2014) that included low marsh (Spartina alterniflora), high marsh (Distichlis spicata and Juncus gerardii-dominated), invasive Phragmites australis zones, and unvegetated ponds. Day-and nighttime fluxes were also contrasted in the native marsh zones. N2O fluxes were measured in parallel with CO2 and CH4 fluxes, but were not found to be significant. To test the relationships of CO2 and CH4 fluxes with several native plant metrics, a multivariate nonlinear model was used. Invasive P. australis zones (-7 to -15 mu mol CO2.m(-2).s(-1)) and S. alterniflora low marsh zones (up to -14 mu mol CO2.m(-2).s(-1)) displayed highest average CO2 -uptake rates, while those in the native high marsh zone (less than -2 mu mol CO2.m(-2).s(-1)) were much lower. Unvegetated ponds were typically small sources of CO2 to the atmosphere (< 0.5 mu mol CO2.m(-2).s(-1)). Night-time emissions of CO2 averaged only 35% of daytime uptake in the low marsh zone, but they exceeded daytime CO2 uptake by up to threefold in the native high marsh zone. Based on modeling, belowground biomass was the plant metric most strongly correlated with CO2 fluxes in native marsh zones, while none of the plant variables correlated significantly with CH4 fluxes. Methane fluxes did not vary between day and night and did not significantly offset CO2 uptake in any vegetated marsh zones based on sustained global warming potential calculations. These findings suggest that attention to spatial zonation as well as expanded measurements and modeling of GHG emissions across greater temporal scales will help to improve accuracy of carbon accounting in coastal marshes. C1 [Moseman-Valtierra, Serena; Quinn, Ryan K.; Martin, Rose M.; Egan, Katharine; Brannon, Elizabeth Q.] Univ Rhode Isl, Dept Biol Sci, 120 Flagg Rd, Kingston, RI 02881 USA. [Abdul-Aziz, Omar I.; Ishtiaq, Khandker S.] West Virginia Univ, Dept Civil & Environm Engn, POB 6103, Morgantown, WV 26506 USA. [Abdul-Aziz, Omar I.] Florida Int Univ, Dept Civil & Environm Engn, 10555 West Flagler St, Miami, FL 33174 USA. [Tang, Jianwu; Morkeski, Kate; Carey, Joanna] Marine Biol Lab, Ctr Ecosyst, 7 MBL St, Woods Hole, MA 02543 USA. [Mora, Jordan] Waquoit Bay Natl Estuarine Res Reserve, 131 Waquoit Highway, Waquoit, MA 02536 USA. [Martin, Rose M.] US EPA, Atlantic Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA. [Kroeger, Kevin D.] US Geol Survey, Coastal & Marine Sci Ctr, 384 Woods Hole Rd, Woods Hole, MA 02543 USA. RP Moseman-Valtierra, S (reprint author), Univ Rhode Isl, Dept Biol Sci, 120 Flagg Rd, Kingston, RI 02881 USA. EM smoseman@uri.edu RI Tang, Jianwu/K-6798-2014; OI Tang, Jianwu/0000-0003-2498-9012; Ishtiaq, Khandker/0000-0003-2130-2908 FU NOAA National Estuarine Research Reserve Science Collaborative [03354]; USDA National Institute of Food and Agriculture, Hatch Project [229286]; National Science Foundation (NSF) CBET Award [1561941/1336911]; NOAA NERRA Grant [NA09NOS4190153]; National Science Foundation Program [EPS-1004057]; USGS Coastal and Marine Geology and LandCarbon Programs FX This research was funded by the NOAA National Estuarine Research Reserve Science Collaborative (Award Number 03354). This work was supported by the USDA National Institute of Food and Agriculture, Hatch Project (229286), awarded to Moseman-Valtierra at URI. Contributions of Abdul-Aziz and Ishtiaq were supported by the National Science Foundation (NSF) CBET Award No. 1561941/1336911 and by the NOAA NERRA Grant No. NA09NOS4190153. R. Martin's fellowship was funded by the National Science Foundation Experimental Program to Stimulate Collaborative Research Cooperative Agreement (#EPS-1004057). Participation of Carey and Kroeger was supported by the USGS Coastal and Marine Geology and LandCarbon Programs. Dr. FIizabeth Watson and Dr. Cathleen Wigand performed pore water sulfide analyses at the Atlantic Ecology Division of the Environmental Protection Agency in Narragansett, RI. Gas flux measurements from ponds were made by Genevieve Rybicki in 2013 and Isabella China in 2014. Additional research assistants including Ian Armitstead, Sean Kelley, Victoria Moebus, Solid Doman. Lauren Krohmer, Karissa Parker, and Michael Callahan helped with the collection, sorting, and weighing of the above- and belowground samples. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the. U.S. Government. NR 53 TC 0 Z9 0 U1 10 U2 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2150-8925 J9 ECOSPHERE JI Ecosphere PD NOV PY 2016 VL 7 IS 11 AR e01560 DI 10.1002/ecs2.1560 PG 21 WC Ecology SC Environmental Sciences & Ecology GA EI1AP UT WOS:000392207600021 ER PT J AU Johns, LE Ferguson, KK Meeker, JD AF Johns, Lauren E. Ferguson, Kelly K. Meeker, John D. TI Relationships Between Urinary Phthalate Metabolite and Bisphenol A Concentrations and Vitamin D Levels in US Adults: National Health and Nutrition Examination Survey (NHANES), 2005-2010 SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM LA English DT Article ID ENDOCRINE DISRUPTING CHEMICALS; EXPOSURE; POPULATION; EXPRESSION; ENZYMES; MODELS; SYSTEM; GENES; WOMEN; MEN AB Context: Recent research suggests that environmental exposure to endocrine-disrupting chemicals may alter circulating 25-hydroxyvitamin D [25(OH)D] levels in humans. To date, no studies have assessed the associations between phthalates and bisphenol A (BPA) and total 25(OH)D in the U.S. general population. Objective: To explore relationships between urinary concentrations of 11 phthalate metabolites and BPA and serum total 25(OH)D in a representative sample of U.S. adults. Design: A cross-sectional study. Setting: U.S. National Health and Nutrition Examination Survey, 2005-2010. Patients or Other Participants: U.S. general adult population (aged ce20 years). Interventions: None Main Outcome Measures: Serum total 25(OH)D measured by liquid chromatography-tandem mass spectrometry. Results: Metabolites of di(2-ethylhexyl) phthalate (DEHP) were consistently inversely associated with total 25(OH)D in the overall study population and in gender-stratified models. In the overall population, we detected a significant inverse relationship for the molar sum of DEHP metabolites (IDEHP), where an interquartile range increase in IDEHP was associated with a 1.90% decrease (95% confidence interval [CI], -3.64, -0.17) in total 25(OH)D. A positive association was detected for monoethyl phthalate. For BPA, we found a statistically significant inverse relationship in women, but not in men. In women, an interquartile range increase in urinary BPA was associated with a 3.71% decrease (95% CI, -6.41, -1.02) in total 25(OH)D. Conclusions: Overall, our results provide suggestive evidence that environmental exposure to phthalates and BPA may alter circulating levels of total 25(OH)D in adults. Future human and animal studies are required to resolvethe direction, temporality, and impact of these relationships. C1 [Johns, Lauren E.; Ferguson, Kelly K.; Meeker, John D.] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA. [Ferguson, Kelly K.] Natl Inst Environm Hlth Sci, Epidemiol Branch, Res Triangle Pk, NC 27709 USA. RP Meeker, JD (reprint author), Dept Environm Hlth Sci, 1835 SPH 1,1415 Washington Hts, Ann Arbor, MI 48109 USA. EM meekerj@umich.edu OI Ferguson, Kelly/0000-0001-8467-3250 FU Intramural Research Program of the National Institutes of Health, National Institute of Environmental Health Sciences; National Institute of Environmental Health Sciences, National Institutes of Health [R01ES018872, P42ES017198, P50ES026049, P01ES0228544, T32ES007062] FX This research was supported in part by the Intramural Research Program of the National Institutes of Health, National Institute of Environmental Health Sciences. Funding was also provided by the National Institute of Environmental Health Sciences, National Institutes of Health (Grants R01ES018872, P42ES017198, P50ES026049, P01ES0228544, and T32ES007062). NR 43 TC 2 Z9 2 U1 6 U2 6 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0021-972X EI 1945-7197 J9 J CLIN ENDOCR METAB JI J. Clin. Endocrinol. Metab. PD NOV PY 2016 VL 101 IS 11 BP 4062 EP 4069 DI 10.1210/jc.2016-2134 PG 8 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA EG3MK UT WOS:000390948600022 PM 27648964 ER PT J AU Lenox, C Kaplan, PO AF Lenox, Carol Kaplan, P. Ozge TI Role of natural gas in meeting an electric sector emissions reduction strategy and effects on greenhouse gas emissions SO ENERGY ECONOMICS LA English DT Article DE Energy system; Scenario analysis; Carbon emissions reductions; Methane; Natural gas ID UNITED-STATES; METHANE EMISSIONS; CLIMATE-CHANGE; UNCERTAINTY; POLICY AB With advances in natural gas extraction technologies, there is an increase in the availability of domestic natural gas, and, natural gas is gaining a larger share of use as a fuel in electricity production. At the power plant, natural gas is a cleaner burning fuel than coal, but uncertainties exist in the amount of methane leakage occurring upstream in the extraction and production of natural gas. At higher leakage levels, the additional methane emissions could offset the carbon dioxide emissions reduction benefit of switching from coal to natural gas. This analysis uses the MARKAL linear optimization model to compare the carbon emissions profiles and system-wide global warming potential of the U.S. energy system over a series of model runs in which the power sector is required to meet a specific carbon dioxide reduction target across a number of scenarios in which the availability of natural gas changes. Scenarios are run with carbon dioxide emissions and a range of upstream methane emission leakage rates from natural gas production along with upstream methane and carbon dioxide emissions associated with production of coal and oil. While the system carbon dioxide emissions are reduced in most scenarios, total carbon dioxide equivalent emissions show an increase in scenarios in which natural gas prices remain low and, simultaneously, methane emissions from natural gas production are higher. Published by Elsevier B.V. C1 [Lenox, Carol; Kaplan, P. Ozge] US EPA, Natl Risk Management Res Lab, Off Res & Dev, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. RP Lenox, C (reprint author), US EPA, Natl Risk Management Res Lab, Off Res & Dev, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM lenox.carol@epa.gov; kaplan.ozge@epa.gov FU EPA Air, Climate, and Energy (ACE) program office FX This research was funded through the EPA Air, Climate, and Energy (ACE) program office. The EPAUS9r MARKAL database has been developed over a number of years by a number of researchers in the U.S. EPA's Office of Research and Development. The current version of the database was a collaborative effort of ORD's Energy and Climate Assessment Team, including Rebecca Dodder, Dan Loughlin, and William Yelverton. A major update to the industrial sector was done with contract support from Jonathan Witt. NR 35 TC 0 Z9 0 U1 4 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0140-9883 EI 1873-6181 J9 ENERG ECON JI Energy Econ. PD NOV PY 2016 VL 60 BP 460 EP 468 DI 10.1016/j.eneco.2016.06.009 PG 9 WC Economics SC Business & Economics GA EF7FR UT WOS:000390496000043 ER PT J AU Sykes, KE Robinson, K AF Sykes, K. E. Robinson, K. TI EMERGING TRENDS AND DATA CHALLENGES: MEASURING THE LATEST ECONOMIC FINDINGS SO GERONTOLOGIST LA English DT Meeting Abstract C1 [Sykes, K. E.] US EPA, Washington, DC 20460 USA. [Robinson, K.] Adm Community Living, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0016-9013 EI 1758-5341 J9 GERONTOLOGIST JI Gerontologist PD NOV PY 2016 VL 56 SU 3 BP 583 EP 584 PG 2 WC Gerontology SC Geriatrics & Gerontology GA ED1DT UT WOS:000388585002650 ER PT J AU Sykes, KE AF Sykes, K. E. TI TWO ENVIRONMENTAL INDICATORS: AIR QUALITY AND THE USE OF TIME SO GERONTOLOGIST LA English DT Meeting Abstract C1 [Sykes, K. E.] US EPA, Washington, DC 20460 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0016-9013 EI 1758-5341 J9 GERONTOLOGIST JI Gerontologist PD NOV PY 2016 VL 56 SU 3 BP 583 EP 583 PG 1 WC Gerontology SC Geriatrics & Gerontology GA ED1DT UT WOS:000388585002646 ER PT J AU Sykes, KE AF Sykes, K. E. TI PREVENTION STRATEGIES TO IMPROVE ENVIRONMENTAL HEALTH SO GERONTOLOGIST LA English DT Meeting Abstract C1 [Sykes, K. E.] US EPA, Off Res & Dev, Washington, DC 20460 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0016-9013 EI 1758-5341 J9 GERONTOLOGIST JI Gerontologist PD NOV PY 2016 VL 56 SU 3 BP 618 EP 618 PG 1 WC Gerontology SC Geriatrics & Gerontology GA ED1DT UT WOS:000388585002792 ER PT J AU Baldauf, RW Devlin, RB Gehr, P Giannelli, R Hassett-Sipple, B Jung, H Martini, G McDonald, J Sacks, JD Walker, K AF Baldauf, Richard W. Devlin, Robert B. Gehr, Peter Giannelli, Robert Hassett-Sipple, Beth Jung, Heejung Martini, Giorgio McDonald, Joseph Sacks, Jason D. Walker, Katherine TI Ultrafine Particle Metrics and Research Considerations: Review of the 2015 UFP Workshop SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH LA English DT Review ID MORTALITY; ASSOCIATIONS; FINE C1 [Baldauf, Richard W.; Devlin, Robert B.; Hassett-Sipple, Beth; McDonald, Joseph; Sacks, Jason D.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Baldauf, Richard W.; Giannelli, Robert; McDonald, Joseph] US EPA, Off Transportat & Air Qual, Ann Arbor, MI 48105 USA. [Gehr, Peter] Univ Bern, Inst Anat, CH-3000 Bern, Switzerland. [Jung, Heejung] Univ Calif Riverside, Dept Mech Engn, Riverside, CA 92521 USA. [Martini, Giorgio] European Commiss, Joint Res Ctr, I-21027 Ispra, Italy. [Walker, Katherine] Hlth Effects Inst, Boston, MA 02110 USA. RP Baldauf, RW (reprint author), US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA.; Baldauf, RW (reprint author), US EPA, Off Transportat & Air Qual, Ann Arbor, MI 48105 USA. EM baldauf.richard@epa.gov; devlin.robert@epa.gov; gehr@ana.unibe.ch; giannelli.bob@epa.gov; hassett-sipple.beth@epa.gov; heejung@engr.ucr.edu; giorgio.martini@jrc.ec.europa.eu; mcdonald.joseph@epa.gov; sacks.jason@epa.gov; KWalker@healtheffects.org NR 14 TC 0 Z9 0 U1 1 U2 1 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 1660-4601 J9 INT J ENV RES PUB HE JI Int. J. Environ. Res. Public Health PD NOV PY 2016 VL 13 IS 11 AR 1054 DI 10.3390/ijerph13111054 PG 21 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA EE4KR UT WOS:000389571300013 ER PT J AU Morgan, M Jones, P Sobus, J Barr, DB AF Morgan, Marsha Jones, Paul Sobus, Jon Barr, Dana Boyd TI Predictors of Urinary 3-Phenoxybenzoic Acid Levels in 50 North Carolina Adults SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH LA English DT Article DE adults; insecticides; exposure; determinants; urine; biomarkers ID DAY-CARE-CENTERS; NEW-YORK-CITY; PYRETHROID INSECTICIDES; PREGNANT-WOMEN; US POPULATION; EXPOSURE; METABOLITES; PESTICIDES; BIOMARKERS; CALIFORNIA AB Limited data are available on the non-chemical stressors that impact adult exposures to pyrethroid insecticides based on urinary biomonitoring. The urinary metabolite, 3-phenoxybenzoic acid (3-PBA), is commonly used to assess human exposure to a number of pyrethroids. In a further analysis of published study data, we quantified urinary 3-PBA levels of 50 adults over a single, 24-h sampling period and examined the associations between the biomarker measurements and selected non-chemical stressors (demographic, lifestyle, and dietary factors). A convenience sample of 50 adults was recruited in North Carolina in 2009-2011. Participants collected individual urine voids (up to 11) and filled out activity, food, and pesticide use diaries over a 24-h sampling period. Urine voids (n = 326) were analyzed for 3-PBA concentrations using high-performance liquid chromatography-tandem mass spectrometry. 3-PBA was detected in 98% of the 24-h composited urine samples. The geometric mean urinary 3-PBA level was 1.68 ng/mL in adults. Time spent outside (p = 0.0006) was a highly significant predictor of natural log-transformed (ln) urinary 3-PBA levels, while consumption of coffee (p = 0.007) and breads (p = 0.019) and ln creatinine levels (p = 0.037) were significant predictors of urinary 3-PBA levels. In conclusion, we identified specific factors that substantially increased adult exposures to pyrethroids in their everyday environments. C1 [Morgan, Marsha; Jones, Paul; Sobus, Jon] US EPA, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. [Barr, Dana Boyd] Emory Univ, Dept Environm Hlth, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. RP Morgan, M (reprint author), US EPA, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM morgan.marsha@epa.gov; paul-a.jones@epa.gov; sobus.jon@epa.gov; dbbarr@Emory.edu FU US EPA FX We would like to thank Fu-Lin Chen, Lillian Alston, Richard Walker, and Eric Andersen for their technical support in the field and laboratory. The Ex-R study was funded wholly by the US EPA. "The US EPA through its Office of Research and Development has provided administrative review of this article and approved it for publication". NR 39 TC 0 Z9 0 U1 2 U2 2 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 1660-4601 J9 INT J ENV RES PUB HE JI Int. J. Environ. Res. Public Health PD NOV PY 2016 VL 13 IS 11 AR 1172 DI 10.3390/ijerph13111172 PG 13 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA EE4KR UT WOS:000389571300130 ER PT J AU Cheng, WY Zhang, Q Schroeder, A Villeneuve, DL Ankley, GT Conolly, R AF Cheng, Wan-Yun Zhang, Qiang Schroeder, Anthony Villeneuve, Daniel L. Ankley, Gerald T. Conolly, Rory TI Editor's Highlight: Computational Modeling of Plasma Vitellogenin Alterations in Response to Aromatase Inhibition in Fathead Minnows SO TOXICOLOGICAL SCIENCES LA English DT Article DE endocrine toxicology; aquatic toxicology; environmental toxicology; predictive toxicology; in vitro and altenatives; adverse outcome pathway; computational toxicology ID CHARACTERIZE ADAPTIVE RESPONSES; REPRODUCTIVE ENDOCRINE AXIS; PIMEPHALES-PROMELAS; DANIO-RERIO; EXPRESSION; GENE; RECEPTOR; FISH; TRANSCRIPTION; DISPOSITION AB In vertebrates, conversion of testosterone into 17 beta-estradiol (E2) is catalyzed by cytochrome P450 (CYP) 19A aromatase. An important role of E2 in oviparous vertebrates such as fish is stimulation of hepatic synthesis of the glycolipoprotein vitellogenin (VTG), an egg yolk precursor essential to oocyte development and larval survival. In fathead minnows (FHMs) (Pimephales promelas) exposed to the aromatase inhibitor fadrozole, plasma VTG levels do not change in concert with plasma E2 levels. Specifically, while plasma VTG and E2 levels both drop quickly when aromatase is first inhibited, the recovery of plasma VTG upon cessation of aromatase inhibition is substantially delayed relative to the recovery of plasma E2. We modified an existing computational model of the FHM hypothalamic-pituitary-gonadal axis to evaluate alternative hypotheses that might explain this delay. In the first hypothesis, a feedback loop involving active transport of VTG from the blood into the ovary is used. The activity of the transporter is negatively regulated by ovarian VTG. In the second hypothesis, a type 1 coherent feed-forward loop is implemented in the liver. This loop has 2 arms, both requiring E2 activation. The first arm describes direct, canonical E2-driven transcriptional induction of VTG, and the second describes an E2-driven intermediate transcriptional regulator that is also required for VTG synthesis. Both hypotheses accurately described the observed VTG dynamics. This result could be used to guide design of laboratory experiments intended to determine if either of the motifs, or perhaps even both of them, actually do control VTG dynamics in FHMs exposed to aromatase inhibitors. C1 [Cheng, Wan-Yun] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Cheng, Wan-Yun; Conolly, Rory] US EPA, Integrated Syst Toxicol Div, Natl Hlth & Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Zhang, Qiang] Emory Univ, Rollins Sch Publ Hlth, Dept Environm Hlth, Atlanta, GA 30322 USA. [Schroeder, Anthony] Univ Minnesota Crookston, Math Sci & Technol Dept, Crookston, MN USA. [Villeneuve, Daniel L.; Ankley, Gerald T.] US EPA, Mid Continent Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Duluth, MN USA. RP Conolly, R (reprint author), US EPA, Integrated Syst Toxicol Div, Natl Hlth & Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. EM conolly.rory@epa.gov NR 37 TC 0 Z9 0 U1 5 U2 5 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD NOV PY 2016 VL 154 IS 1 BP 78 EP 89 DI 10.1093/toxsci/kfw142 PG 12 WC Toxicology SC Toxicology GA ED6CA UT WOS:000388940900009 PM 27503384 ER PT J AU Brown, JP Hall, D Frank, CL Wallace, K Mundy, WR Shafer, TJ AF Brown, Jasmine P. Hall, Diana Frank, Christopher L. Wallace, Kathleen Mundy, William R. Shafer, Timothy J. TI Editor's Highlight: Evaluation of a Microelectrode Array-Based Assay for Neural Network Ontogeny Using Training Set Chemicals SO TOXICOLOGICAL SCIENCES LA English DT Article DE alternatives to animal testing; in vitro and alternatives; neurotoxicity; developmental; neurotoxicology; electrophysiology; screening ID IN-VITRO; DEVELOPMENTAL NEUROTOXICITY; CORTICAL-NEURONS; NEUROPROGENITOR CELLS; NEURITE OUTGROWTH; MULTIPLEXED ASSAY; PRIMARY CULTURES; NERVOUS-SYSTEM; SENSITIVITY; APOPTOSIS AB Thousands of compounds in the environment have not been characterized for developmental neurotoxicity (DNT) hazard. To address this issue, methods to screen compounds rapidly for DNT hazard evaluation are necessary and are being developed for key neurodevelopmental processes. In order to develop an assay for network formation, this study evaluated effects of a training set of chemicals on network ontogeny by measuring spontaneous electrical activity in neural networks grown on microelectrode arrays (MEAs). Rat (0-24 h old) primary cortical cells were plated in 48 well-MEA plates and exposed to 6 compounds: acetaminophen, bisindolylmaleimide-1 (Bis-1), domoic acid, mevastatin, sodium orthovanadate, and loperamide for a period of 12 days. Spontaneous network activity was recorded on days 2, 5, 7, 9, and 12 and viability was assessed using the Cell Titer Blue assay on day 12. Network activity (e.g. mean firing rate [MFR], burst rate [BR], etc), increased between days 5 and 12. Random Forest analysis indicated that across all compounds and times, temporal correlation of firing patterns (r), MFR, BR, number of active electrodes and % of spikes in a burst were the most influential parameters in separating control from treated wells. All compounds except acetaminophen (<= 30 A mu M) caused concentration-related effects on one or more of these parameters. Domoic acid and sodium orthovanadate altered several of these parameters in the absence of cytotoxicity. Although cytotoxicity was observed with Bis1, mevastatin, and loperamide, some parameters were affected by these compounds at concentrations below those resulting in cytotoxicity. These results demonstrate that this assay may be suitable for screening of compounds for DNT hazard identification. C1 [Brown, Jasmine P.; Hall, Diana; Frank, Christopher L.; Wallace, Kathleen; Mundy, William R.; Shafer, Timothy J.] US EPA, NHEERL, Res Triangle Pk, NC 27711 USA. RP Shafer, TJ (reprint author), US EPA, Integrated Syst Toxicol Div, MD B105-03, Res Triangle Pk, NC 27711 USA. EM shafer.tim@epa.gov FU Student Services Contracts [EP-14-D-000101, EP-13-D-000108] FX J.P.B. and D.H. were supported by Student Services Contracts EP-14-D-000101 and EP-13-D-000108, respectively. NR 68 TC 0 Z9 0 U1 6 U2 6 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD NOV PY 2016 VL 154 IS 1 BP 126 EP 139 DI 10.1093/toxsci/kfw147 PG 14 WC Toxicology SC Toxicology GA ED6CA UT WOS:000388940900013 PM 27492221 ER PT J AU Harrill, AH McCullough, SD Wood, CE Kahle, JJ Chorley, BN AF Harrill, Alison H. McCullough, Shaun D. Wood, Charles E. Kahle, Juliette J. Chorley, Brian N. TI MicroRNA Biomarkers of Toxicity in Biological Matrices (vol 152, pg 264, 2016) SO TOXICOLOGICAL SCIENCES LA English DT Correction C1 [Chorley, Brian N.] US EPA, ORD, Res Triangle Pk, NC 27711 USA. RP Chorley, BN (reprint author), US EPA, ORD, Res Triangle Pk, NC 27711 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD NOV PY 2016 VL 154 IS 1 BP 196 EP 196 DI 10.1093/toxsci/kfw184 PG 1 WC Toxicology SC Toxicology GA ED6CA UT WOS:000388940900021 ER PT J AU Carriger, JF Martin, TM Barron, MG AF Carriger, John F. Martin, Todd M. Barron, Mace G. TI A Bayesian network model for predicting aquatic toxicity mode of action using two dimensional theoretical molecular descriptors SO AQUATIC TOXICOLOGY LA English DT Article DE Mode of action; Aquatic toxicity; Bayesian network; Markov blanket; Chemical descriptors ID PIMEPHALES-PROMELAS; NEURAL-NETWORKS; FATHEAD MINNOW; QSAR MODELS; CLASSIFICATION; CHEMICALS AB The mode of toxic action (MoA) has been recognized as a key determinant of chemical toxicity, but development of predictive MoA classification models in aquatic toxicology has been limited. We developed a Bayesian network model to classify aquatic toxicity MoA using a recently published dataset containing over one thousand chemicals with MoA assignments for aquatic animal toxicity. Two dimensional theoretical chemical descriptors were generated for each chemical using the Toxicity Estimation Software Tool. The model was developed through augmented Markov blanket discovery from the dataset of 1098 chemicals with the MoA broad classifications as a target node. From cross validation, the overall precision for the model was 80.2%. The best precision was for the AChEI MoA (93.5%) where 257 chemicals out of 275 were correctly classified. Model precision was poorest for the reactivity MoA (48.5%) where 48 out of 99 reactive chemicals were correctly classified. Narcosis represented the largest class within the MoA dataset and had a precision and reliability of 80.0%, reflecting the global precision across all of the MoAs. False negatives for narcosis most often fell into electron transport inhibition, neurotoxicity or reactivity MoAs. False negatives for all other MoAs were most often narcosis. A probabilistic sensitivity analysis was undertaken for each MoA to examine the sensitivity to individual and multiple descriptor findings. The results show that the Markov blanket of a structurally complex dataset can simplify analysis and interpretation by identifying a subset of the key chemical descriptors associated with broad aquatic toxicity MoAs, and by providing a computational chemistry-based network classification model with reasonable prediction accuracy. Published by Elsevier B.V. C1 [Carriger, John F.; Barron, Mace G.] US EPA, Off Res & Dev, Gulf Ecol Div, Gulf Breeze, FL 32561 USA. [Martin, Todd M.] US EPA, Off Res & Dev, Sustainable Technol Div, Cincinnati, OH 45220 USA. RP Barron, MG (reprint author), US EPA, Off Res & Dev, Gulf Ecol Div, Gulf Breeze, FL 32561 USA. EM barron.mace@epa.gov FU U.S. EPA; U.S. Department of Energy FX This research was supported in part by an appointment to the ORISE participant research program supported by an interagency agreement between the U.S. EPA and the U.S. Department of Energy. We thank Tom Stockton and Chris Grulke for review of a draft of the manuscript. The conclusions may not necessarily reflect the views of EPA and no official endorsement should be inferred. NR 30 TC 1 Z9 1 U1 4 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-445X EI 1879-1514 J9 AQUAT TOXICOL JI Aquat. Toxicol. PD NOV PY 2016 VL 180 BP 11 EP 24 DI 10.1016/j.aquatox.2016.09.006 PG 14 WC Marine & Freshwater Biology; Toxicology SC Marine & Freshwater Biology; Toxicology GA ED3VW UT WOS:000388777600002 PM 27640153 ER PT J AU Milsk, R Cavallin, JE Durhan, EJ Jensen, KM Kahl, MD Makynen, EA Martinovic-Weigelt, D Mueller, N Schroeder, A Villeneuve, DL Ankley, GT AF Milsk, Rebecca Cavallin, Jenna E. Durhan, Elizabeth J. Jensen, Kathleen M. Kahl, Michael D. Makynen, Elizabeth A. Martinovic-Weigelt, Dalma Mueller, Nathan Schroeder, Anthony Villeneuve, Daniel L. Ankley, Gerald T. TI A study of temporal effects of the model anti-androgen flutamide on components of the hypothalamic-pituitary-gonadal axis in adult fathead minnows SO AQUATIC TOXICOLOGY LA English DT Article DE Androgen receptor; Antagonist; Flutamide; Fish; Reproduction; Adverse outcome pathway ID RAINBOWFISH MELANOTAENIA-FLUVIATILIS; ENDOCRINE-DISRUPTING CHEMICALS; ADVERSE OUTCOME PATHWAYS; TERM REPRODUCTION ASSAY; MEDAKA ORYZIAS-LATIPES; PIMEPHALES-PROMELAS; SEXUAL DEVELOPMENT; OOCYTE MATURATION; END-POINTS; ANDROGEN AB The aim of this study was to investigate temporal changes in the hypothalamic-pituitary-gonadal (HPG) axis of fathead minnows (Pimephales promelas) treated with the model androgen receptor (AR) antagonist flutamide. Reproductively-mature fish were exposed in a flow-through test to analytically-confirmed concentrations of either 50 or 500 mu g flutamide/L for 8 d, followed by an 8-d recovery period in clean water. Fish were sampled at 1, 2, 4 and 8 days during each phase of the experiment. Flutamide (500 mu 4/1.) caused significant reductions in relative gonad size of the females on day 8 of the exposure and day 1 of the recovery, and reduced expression of secondary sex characteristics in males during the exposure phase of the experiment. Ex vivo gonadal synthesis of testosterone in both sexes (and 17 beta-estradiol in females) was reduced in the 500 mu g/I. treatment within 2 d of exposure; however, steroid synthesis returned to levels comparable to controls by the end of the exposure portion of the test. Ex vivo testosterone synthesis in males exposed to 50 mu g flutamide/L was greater than in controls on days 4 and 8 of the exposure. Both the enhanced steroid production in the low treatment males, and return to control levels in the high treatment males and females during chemical exposure are indicative of a compensatory HPG response. One contributor to this response could be increased expression of genes responsible for enzymes involved in steroid synthesis; for example, transcripts for both cytochrome P450 side- chain cleavage and 11 beta-hydroxysteroid dehydrogenase were significantly elevated in flutamideexposed males. Overall, responses of the HPG axis in adult male and female fathead minnows exposed to flutamide were both dynamic and comparatively rapid during exposure and recovery. These observations have ramifications both for the development of short-term fish assays to detect endocrine-active chemicals, and the derivation of robust adverse outcome pathways for AR antagonists in fish. Published by Elsevier B.V. C1 [Milsk, Rebecca] Oak Ridge Inst Sci Educ Res Participat Program, Midcontinent Ecol Div, Duluth, MN USA. [Cavallin, Jenna E.] Badger Tech Serv, Midcontinent Ecol Div, Duluth, MN USA. [Durhan, Elizabeth J.; Jensen, Kathleen M.; Kahl, Michael D.; Makynen, Elizabeth A.; Villeneuve, Daniel L.; Ankley, Gerald T.] US EPA, Midcontinent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA. [Martinovic-Weigelt, Dalma] Univ St Thomas, Dept Biol, St Paul, MN USA. [Mueller, Nathan] Harvard Univ, Organism & Evolutionary Biol, Cambridge, MA 02138 USA. [Schroeder, Anthony] Univ Minnesota Crookston, Dept Biol, Crookston, MN USA. RP Ankley, GT (reprint author), US EPA, Midcontinent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA. EM ankley.gerald@epa.gov FU US EPA Chemical Safety for Sustainability Research Program FX We thank Kellie Fay for helpful comments on an earlier draft of this paper. Funding for this work was provided in part by the US EPA Chemical Safety for Sustainability Research Program. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. The contents of this manuscript neither constitute, nor necessarily reflect US EPA policy. NR 41 TC 0 Z9 0 U1 6 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-445X EI 1879-1514 J9 AQUAT TOXICOL JI Aquat. Toxicol. PD NOV PY 2016 VL 180 BP 164 EP 172 DI 10.1016/j.aquatox.2016.09.021 PG 9 WC Marine & Freshwater Biology; Toxicology SC Marine & Freshwater Biology; Toxicology GA ED3VW UT WOS:000388777600017 PM 27716581 ER PT J AU Ingle, BL Veber, BC Nichols, JW Tornero-Velez, R AF Ingle, Brandall L. Veber, Brandon C. Nichols, John W. Tornero-Velez, Rogelio TI Informing the Human Plasma Protein Binding of Environmental Chemicals by Machine Learning in the Pharmaceutical Space: Applicability Domain and Limits of Predictability SO Journal of Chemical Information and Modeling LA English DT Article ID IN-VITRO; RANDOM FOREST; EXPOSURE; QSAR; MODELS; PREDICTION; PARAMETERS; DOSIMETRY; SILICO; STATE AB The free fraction of a xenobiotic in plasma (Fob) is an important determinant of chemical adsorption, tic distribution, metabolism, elimination, and toxicity, yet experimental plasma protein binding data are scarce for environmentally relevant chemicals. The presented work explores the merit of utilizing available pharmaceutical data to predict F-ub for environmentally relevant chemicals via machine learning techniques. Quantitative structure activity relationship (QSAR) models were constructed with k nearest neighbors (INN), support vector machines (SVM), and random forest (RF) machine learning algorithms from a training set of 1045 pharmaceuticals. The models were then evaluated with independent test sets of pharmaceuticals (200 compounds) and environmentally relevant ToxCast chemicals (406 total, in two groups of 238 and 168 compounds). The selection of a minimal feature set of 10-15 2D molecular descriptors allowed for both informative feature interpretation and practical applicability domain assessment via a bounded box of descriptor ranges and principal component analysis. The diverse pharmaceutical and environmental chemical sets exhibit similarities in terms of chemical space (99-82% overlap), as well as comparable bias and variance in constructed learning curves. All the models exhibit significant predictability with mean absolute errors (MAE) in the range of 0.10-0.18F(ub). The models performed best for highly bound chemicals (MAE 0.07-0.12), neutrals (MAE 0.11-0.14), and acids (MAE 0.14-0.17). A consensus model had the highest accuracy across both pharmaceuticals (MAE 0.151-0.155) and environmentally relevant chemicals (MAE 0.110-0.131). The inclusion of the majority of the ToxCast test sets within the AD of the consensus model, coupled with high prediction accuracy for these chemicals, indicates the model provides a QSAR for F-ub that is broadly applicable to both pharmaceuticals and environmentally relevant chemicals. C1 [Ingle, Brandall L.; Tornero-Velez, Rogelio] US EPA, Off Res & Dev, Natl Exposure Res Lab, Res Triangle Pk, NC 27709 USA. [Veber, Brandon C.; Nichols, John W.] US EPA, Off Res & Dev, Natl Hlth Exposure Effects Res Lab, Duluth, MN 55804 USA. [Veber, Brandon C.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37830 USA. RP Tornero-Velez, R (reprint author), 109 TW Alexander Dr,Mail Code E205-01, Res Triangle Pk, NC 27709 USA. EM tornero-velez.rogelio@epa.gov FU U.S. Environmental Protection Agency through its Office of Research and Development; Oak Ridge Institute for Science and Education Research Participation Program at the U.S. Environmental Protection Agency FX The U.S. Environmental Protection Agency through its Office of Research and Development funded and managed the research described here. B.V. was funded by the Oak Ridge Institute for Science and Education Research Participation Program at the U.S. Environmental Protection Agency. NR 40 TC 0 Z9 0 U1 11 U2 11 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1549-9596 EI 1549-960X J9 J CHEM INF MODEL JI J. Chem Inf. Model. PD NOV PY 2016 VL 56 IS 11 BP 2243 EP 2252 DI 10.1021/acs.jcim.6b00291 PG 10 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Computer Science, Information Systems; Computer Science, Interdisciplinary Applications SC Pharmacology & Pharmacy; Chemistry; Computer Science GA ED8IW UT WOS:000389116200012 PM 27684444 ER PT J AU Ahmad, N Derrible, S Eason, T Cabezas, H AF Ahmad, Nasir Derrible, Sybil Eason, Tarsha Cabezas, Heriberto TI Using Fisher information to track stability in multivariate systems SO Royal Society Open Science LA English DT Article DE Fisher information; data mining; big data; information science ID REGIME CHANGES; URBAN SYSTEMS; SUSTAINABILITY; ANTHROPOCENE; RESILIENCE; SHIFTS; OHIO; USA AB With the current proliferation of data, the proficient use of statistical and mining techniques offer substantial benefits to capture useful information from any dataset. As numerous approaches make use of information theory concepts, here, we discuss how Fisher information (FI) can be applied to sustainability science problems and used in data mining applications by analysing patterns in data. FI was developed as a measure of information content in data, and it has been adapted to assess order in complex system behaviour. The main advantage of the approach is the ability to collapse multiple variables into an index that can be used to assess stability and track overall trends in a system, including its regimes and regime shifts. Here, we provide a brief overview of FI theory, followed by a simple step-by-step numerical example on how to compute FI. Furthermore, we introduce an open source Python library that can be freely downloaded from GitHub and we use it in a simple case study to evaluate the evolution of FI for the global-mean temperature from 1880 to 2015. Results indicate significant declines in FI starting in 1978, suggesting a possible regime shift. C1 [Ahmad, Nasir; Derrible, Sybil] Univ Illinois, Complex & Sustainable Urban Networks CSUN Lab, Chicago, IL 60607 USA. [Eason, Tarsha; Cabezas, Heriberto] US EPA, Sustainable Technol Div, Off Res & Dev, Cincinnati, OH 45268 USA. [Cabezas, Heriberto] Pazmany Peter Catholic Univ, Fac Informat Technol & Bion, Budapest, Hungary. RP Ahmad, N (reprint author), Univ Illinois, Complex & Sustainable Urban Networks CSUN Lab, Chicago, IL 60607 USA. EM sahmad38@uic.edu FU NSF award [CCF-1331800]; University of Illinois at Chicago Institute for Environmental Science and Policy (IESP) Pre-Doctoral Fellowship; Department of Civil and Materials Engineering at the University of Illinois at Chicago FX This research was supported, in part, by NSF award CCF-1331800, by the University of Illinois at Chicago Institute for Environmental Science and Policy (IESP) Pre-Doctoral Fellowship and by the Department of Civil and Materials Engineering at the University of Illinois at Chicago. NR 37 TC 0 Z9 0 U1 3 U2 3 PU ROYAL SOC PI LONDON PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND SN 2054-5703 J9 ROY SOC OPEN SCI JI R. Soc. Open Sci. PD NOV PY 2016 VL 3 IS 11 AR 160582 DI 10.1098/rsos.160582 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EE0DR UT WOS:000389244400042 PM 28018650 ER PT J AU Joyce, AS Portis, LM Parks, AN Burgess, RM AF Joyce, Abigail S. Portis, Lisa M. Parks, Ashley N. Burgess, Robert M. TI Evaluating the Relationship between Equilibrium Passive Sampler Uptake and Aquatic Organism Bioaccumulation SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Review ID SOLID-PHASE MICROEXTRACTION; PERFORMANCE REFERENCE COMPOUNDS; SEMIPERMEABLE-MEMBRANE DEVICES; POLYCYCLIC AROMATIC-HYDROCARBONS; WATER PARTITION-COEFFICIENTS; SEDIMENT QUALITY CRITERIA; FIELD-COLLECTED SEDIMENTS; LOW-DENSITY POLYETHYLENE; EMERGING CONCERN CECS; ACTIVATED CARBON AB This Critcal Review evaluates passive sampler uptake of hydrophobic organic contaminants (HOCs) in water column and interstitial water exposures as a surrogate for organism bioaccumulation. Fifty-seven studies were found where both passive sampler uptake and organism bioaccumulation were measured and 19 of these investigations provided direct comparisons relating passive sampler uptake and organism bioaccumulation. Polymers compared included low-density polyethylene (LDPE), polyoxymethylene (POM), and polydimethylsiloxane (PDMS), and organisms ranged from polychaetes and oligochaetes to bivalves, aquatic insects, and gastropods. Regression equations correlating bioaccumulation (C-L) and passive sampler uptake (C-PS) were used to assess the strength of observed relationships. Passive sampling based concentrations resulted in loglog predictive relationships, most of which were within one to 2 orders of magnitude of measured bioaccumulation. Mean coefficients of determination (r(2)) for LDPE, PDMS, and POM were 0.68, 0.76, and 0.58, respectively. For the available raw, untransformed data, the mean ratio of C-L and C-PS was 10.8 +/- 18.4 (n = 609). Using passive sampling as a surrogate for organism bioaccumulation is viable when biomonitoring organisms are not available. Passive sampling based estimates of bioaccumulation provide useful information for making informed decisions about the bioavailability of HOCs. C1 [Joyce, Abigail S.; Parks, Ashley N.; Burgess, Robert M.] US EPA, ORD NHEERL Atlantic Ecol Div, Narragansett, RI 02882 USA. [Portis, Lisa M.] Univ Rhode Isl, Phys Therapy Dept, Kingston, RI 02881 USA. RP Joyce, AS (reprint author), US EPA, ORD NHEERL Atlantic Ecol Div, Narragansett, RI 02882 USA. EM joyce.abbey@epa.gov OI Joyce, Abigail/0000-0002-5322-3035 FU NRC Research Associateship award at U.S.Environmental Protection Agency, ORD/NHEERL Atlantic Ecology Division FX This research was performed while A. S. Joyce held an NRC Research Associateship award at U.S.Environmental Protection Agency, ORD/NHEERL Atlantic Ecology Division. The authors thank the AED reviewers for their comments: M. Cantwell, J. Li Volsi, R. McKinney, W. Munns, J. Serbst, and G. Thursby. The following colleagues are also thanked for providing their raw data for analysis in this review: L. Fernandez (Northeastern University, Boston, MA, USA); A. M. P Oen (Norwegian Geotechnical Institute (NGI), Norway, Oslo), E. Janssen (ETH, Zurich, Switzerland), G. Comelissen (NGI) and A. Ruus (Norwegian Institute for Water Research, Oslo, Norway); K. Maruya (Southern California Coastal Water Research Project, Costa Mesa, CA, USA); F. Smedes (Deltares, Utrecht, The Netherlands); and C. Friedman (Corning School of Ocean Studies, Maine Maritime Academy, Castine, ME, USA). NR 111 TC 1 Z9 1 U1 13 U2 13 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD NOV 1 PY 2016 VL 50 IS 21 BP 11437 EP 11451 DI 10.1021/acs.est.6b03273 PG 15 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA EA9UV UT WOS:000386991100003 PM 27680295 ER PT J AU Dodder, RS Barnwell, JT Yelverton, WH AF Dodder, Rebecca S. Barnwell, Jessica T. Yelverton, William H. TI Scenarios for Low Carbon and Low Water Electric Power Plant Operations: Implications for Upstream Water Use SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID UNITED-STATES; UNCONVENTIONAL OIL; CONVENTIONAL OIL; CLIMATE-CHANGE; POTENTIAL IMPACTS; ENERGY-PRODUCTION; NATURAL-GAS; AIR-QUALITY; GENERATION; FUTURE AB Electric sector water use, in particular for thermoelectric operations, is a critical component of the water-energy nexus. On a life cycle basis per unit of electricity generated, operational (e.g., cooling system) water use is substantially higher than water demands for the fuel cycle (e.g., natural gas and coal) and power plant manufacturing (e.g., equipment and construction). However, could shifting toward low carbon and low water electric power operations create trade-offs across the electricity life cycle? We compare business-as-usual with scenarios of carbon reductions and water constraints using the MARKet ALlocation (MARKAL) energy system model. Our scenarios show that, for water withdrawals, the trade-offs are minimal: operational water use accounts for over 95% of life cycle withdrawals. For water consumption, however, this analysis identifies potential trade-offs under some scenarios. Nationally, water use for the fuel cycle and power plant manufacturing can reach up to 26% of the total life cycle consumption. In the western United States, nonoperational consumption can even exceed operational demands. In particular, water use for biomass feedstock irrigation and manufacturing/construction of solar power facilities could increase with high deployment. As the United States moves toward lower carbon electric power operations, consideration of shifting water demands can help avoid unintended consequences. C1 [Dodder, Rebecca S.; Barnwell, Jessica T.; Yelverton, William H.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA. RP Dodder, RS (reprint author), US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA. EM dodder.rebecca@epa.gov NR 64 TC 0 Z9 0 U1 4 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD NOV 1 PY 2016 VL 50 IS 21 BP 11460 EP 11470 DI 10.1021/acs.est.6b03048 PG 11 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA EA9UV UT WOS:000386991100005 PM 27709910 ER PT J AU Xu, CH Zhang, BL Wang, YH Shao, QQ Zhou, WZ Fan, DM Bandstra, JZ Shi, ZQ Tratnyek, PG AF Xu, Chunhua Zhang, Bingliang Wang, Yahao Shao, Qianqian Zhou, Weizhi Fan, Dimin Bandstra, Joel Z. Shi, Zhenqing Tratnyek, Paul G. TI Effects of Sulfidation, Magnetization, and Oxygenation on Azo Dye Reduction by Zerovalent Iron SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID ZERO-VALENT IRON; ACID-MINE DRAINAGE; CORROSION ELECTROCHEMISTRY; LABORATORY EVALUATION; FE/FES NANOPARTICLES; ARSENITE REMOVAL; AQUEOUS-SOLUTION; ORANGE II; FIELD; DEGRADATION AB Applications of zerovalent iron (ZVI) for water treatment under aerobic conditions include sequestration of metals (e.g., in acid mine drainage) and decolorization of dyes (in wastewaters from textile manufacturing). The processes responsible for contaminant removal can be a complex mixture of reduction, oxidation, sorption, and coprecipitation processes, which are further complicated by the dynamics of oxygen intrusion, mixing, and oxide precipitation. To better understand such systems, the removal of an azo dye (Orange I) by micron-sized granular ZVI at neutral pH was studied in open (aerobic) stirred batch reactors, by measuring the kinetics of Orange I decolorization and changes in geochemical properties (DO, Fe(II), and Eh), with and without two treatments that might improve the long-term performance of this system: sulfidation by pretreatment with sulfide and magnetization by application of a weak magnetic field (WMF). The results show that the changes in solution chemistry are coupled to the dynamics of oxygen intrusion, which was modeled as analogous to dissolved oxygen sag curves. Both sulfidation and magnetization increased Orange I removal rates 2.4-71.8-fold, but there was little synergistic benefit to applying both enhancements together. Respike experiments showed that the enhancement from magnetization carries over from magnetization to sulfidation, but not the reverse. C1 [Xu, Chunhua; Zhang, Bingliang; Wang, Yahao; Shao, Qianqian; Zhou, Weizhi] Shandong Univ, Sch Environm Sci & Engn, Jinan 250100, Shandong, Peoples R China. [Fan, Dimin] US EPA, Off Superfund Remediat & Technol Innovat, Arlington, VA 22202 USA. [Bandstra, Joel Z.] St Francis Univ, Sch Sci, 117 Evergreen Dr, Loretto, PA 15940 USA. [Shi, Zhenqing] South China Univ Technol, Sch Environm & Energy, Guangzhou 510006, Guangdong, Peoples R China. [Tratnyek, Paul G.] Oregon Hlth & Sci Univ, Inst Environm Hlth, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA. RP Xu, CH (reprint author), Shandong Univ, Sch Environm Sci & Engn, Jinan 250100, Shandong, Peoples R China.; Tratnyek, PG (reprint author), Oregon Hlth & Sci Univ, Inst Environm Hlth, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA. EM xuchunhua@sdu.edu.cn; tratnyek@ohsu.edu RI fan, dimin/D-3200-2017 FU National Major Special Technological Programs Concerning Water Pollution Control and Management in the Twelfth Five-year Plan Period [2012 ZX07203-004]; National Natural Science Foundation of China [51102157]; U.S. Department of Defense, Strategic Environmental Research and Development Program (SERDP) [ER-2308] FX The primary support of this research was the National Major Special Technological Programs Concerning Water Pollution Control and Management in the Twelfth Five-year Plan Period (No. 2012 ZX07203-004) and the National Natural Science Foundation of China (Grant No. 51102157). Some aspects of the data analysis and interpretation were supported by the U.S. Department of Defense, Strategic Environmental Research and Development Program (SERDP, Award Number ER-2308). NR 63 TC 0 Z9 0 U1 38 U2 38 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD NOV 1 PY 2016 VL 50 IS 21 BP 11879 EP 11887 DI 10.1021/acs.est.6b03184 PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA EA9UV UT WOS:000386991100051 PM 27684600 ER PT J AU Csiszar, SA Meyer, DE Dionisio, KL Egeghy, P Isaacs, KK Price, PS Scanlon, KA Tan, YM Thomas, K Vallero, D Bare, JC AF Csiszar, Susan A. Meyer, David E. Dionisio, Kathie L. Egeghy, Peter Isaacs, Kristin K. Price, Paul S. Scanlon, Kelly A. Tan, Yu-Mei Thomas, Kent Vallero, Daniel Bare, Jane C. TI Conceptual Framework To Extend Life Cycle Assessment Using Near Field Human Exposure Modeling and High-Throughput Tools for Chemicals SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID POLYBROMINATED DIPHENYL ETHERS; ENVIRONMENTAL-PROTECTION-AGENCY; TOXICS RELEASE INVENTORY; NESTED MULTIMEDIA FATE; AIR-POLLUTANT EXPOSURE; HEALTH-RISK ASSESSMENT; IN-VITRO BIOACTIVITY; IMPACT ASSESSMENT; CONSUMER PRODUCTS; DECISION-MAKING AB Life Cycle Assessment (LCA) is a decision-making tool that accounts for multiple impacts across the life cycle of a product or service. This paper presents a conceptual framework to integrate human health impact assessment with risk screening approaches to extend LCA to include near-field chemical sources (e.g., those originating from consumer products and building materials) that have traditionally been excluded from LCA. A new generation of rapid human exposure modeling and high-throughput toxicity testing is transforming chemical risk prioritization and provides an opportunity for integration of screening-level risk assessment (RA) with LCA. The combined LCA and RA approach considers environmental impacts of products alongside risks to human health, which is consistent with regulatory frameworks addressing RA within a sustainability mindset. A case study is presented to juxtapose LCA and risk screening approaches for a chemical used in a consumer product. The case study demonstrates how these new risk screening tools can be used to inform toxicity impact estimates in LCA and highlights needs for future research. The framework provides a basis for developing tools and methods to support decision making on the use of chemicals in products. C1 [Csiszar, Susan A.] US EPA, Oak Ridge Inst Sci & Educ ORISE, Res Participat Program, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA. [Meyer, David E.; Bare, Jane C.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA. [Dionisio, Kathie L.; Egeghy, Peter; Isaacs, Kristin K.; Price, Paul S.; Tan, Yu-Mei; Thomas, Kent; Vallero, Daniel] US EPA, Off Res & Dev, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Scanlon, Kelly A.] US EPA, Off Air & Radiat, Off Radiat & Indoor Air, Washington, DC 20460 USA. RP Bare, JC (reprint author), US EPA, Natl Risk Management Res Lab, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA. EM bare.jane@epa.gov FU U.S. Department of Energy [DW-89-92298301]; U.S. EPA [DW-89-92298301] FX This research was part of the Chemical Safety for Sustainability National Research Program in the U.S. Environmental Protection Agency's (EPA) Office of Research and Development. This research was supported in part by an appointment of S. Csiszar to the Postdoctoral Research Program at the National Risk Management Research Laboratory, Office of Research and Development, U.S. EPA administered by the Oak Ridge Institute for Science and Education through Interagency Agreement No. DW-89-92298301 between the U.S. Department of Energy and the U.S. EPA. Expert support from the U.S. EPA's Office of Air and Radiation, Indoor Environments Division is appreciated. The views expressed in this article are those of the authors and do not necessarily represent the views or policies of the U.S. Environmental Protection Agency. NR 135 TC 2 Z9 2 U1 9 U2 9 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD NOV 1 PY 2016 VL 50 IS 21 BP 11922 EP 11934 DI 10.1021/acs.est.6b02277 PG 13 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA EA9UV UT WOS:000386991100056 PM 27668689 ER PT J AU Raimondo, S Hemmer, BL Lilavois, CR Krzykwa, J Almario, A Awkerman, JA Barron, MG AF Raimondo, Sandy Hemmer, Becky L. Lilavois, Crystal R. Krzykwa, Julie Almario, Alex Awkerman, Jill A. Barron, Mace G. TI Effects of Louisiana Crude Oil on the Sheepshead Minnow (Cyprinodon Variegatus) During a Life-Cycle Exposure to Laboratory Oiled Sediment SO ENVIRONMENTAL TOXICOLOGY LA English DT Article DE sediment exposure; chronic toxicity; fish; oil; reproductive effects; growth effects; polycyclic aromatic hydrocarbons ID KILLIFISH FUNDULUS-GRANDIS; GULF-OF-MEXICO; SYNERGISTIC TOXICITY; NATURAL MORTALITY; SPILL; FISH; POPULATIONS; GROWTH; DISPERSANT; HETEROCLITUS AB Determining the long-term effects of crude oil exposure is critical for ascertaining population-level ecological risks of spill events. A 19-week complete life-cycle experiment was conducted with the estuarine sheepshead minnow (Cyprinodon variegatus) exposed to reference (uncontaminated) sediment spiked with laboratory weathered South Louisiana crude (SLC) oil at five concentrations as well as one unspiked sediment control and one seawater (no sediment) control. Newly hatched larvae were exposed to the oiled sediments at measured concentrations of <1 (sediment control), 50, 103, 193, 347, and 711 mg total polyaromatic hydrocarbons (tPAH)/kg dry sediment. Juveniles were exposed through the reproductively active adult phase at measured concentrations of <1 (sediment control), 52, 109, 199, 358, and 751 mg tPAH/kg sediment. Throughout the exposure, fish were assessed for growth, survival, and reproduction. Resulting F1 embryos were then collected, incubated, and hatched in clean water to determine if parental full life-cycle exposure to oiled sediment produced trans-generational effects. Larvae experienced significantly reduced standard length (5-13% reduction) and wet weight (13-35% reduction) at concentrations at and above 50 and 103 mg tPAH/kg sediment, respectively. At 92 and 132 days post hatch (dph), standard length was reduced (7-13% reduction) at 199 and 109 mg tPAH/kg dry sediment, respectively, and wet weight for both time periods was reduced at concentrations at and above 109 mg tPAH/kg dry sediment (21-38% reduction). A significant reduction (51-65%) in F0 fecundity occurred at the two highest test concentrations, but no difference was observed in F1 embryo survival. This study is the first to report the effects of chronic laboratory exposure to oiled sediment, and will assist the development of population models for evaluating risk to benthic spawning fish species exposed to oiled sediments. (C) 2015 Wiley Periodicals, Inc. C1 [Raimondo, Sandy; Hemmer, Becky L.; Lilavois, Crystal R.; Krzykwa, Julie; Almario, Alex; Awkerman, Jill A.; Barron, Mace G.] US EPA, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA. RP Raimondo, S (reprint author), US EPA, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA. EM Raimondo.sandy@epa.gov NR 49 TC 1 Z9 1 U1 7 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1520-4081 EI 1522-7278 J9 ENVIRON TOXICOL JI Environ. Toxicol. PD NOV PY 2016 VL 31 IS 11 BP 1627 EP 1639 DI 10.1002/tox.22167 PG 13 WC Environmental Sciences; Toxicology; Water Resources SC Environmental Sciences & Ecology; Toxicology; Water Resources GA ED1PF UT WOS:000388616700033 PM 26129909 ER PT J AU Beaulieu, JJ McManus, MG Nietch, CT AF Beaulieu, Jake J. McManus, Michael G. Nietch, Christopher T. TI Estimates of reservoir methane emissions based on a spatially balanced probabilistic-survey SO LIMNOLOGY AND OCEANOGRAPHY LA English DT Article ID FRESH-WATER; DIFFUSIVE METHANE; GAS-EXCHANGE; HOT-SPOTS; LAKE; EBULLITION; CARBON; RESOURCES; MAGNITUDE; TRANSPORT AB Global estimates of methane (CH4) emissions from reservoirs are poorly constrained, partly due to the challenges of accounting for intra-reservoir spatial variability. Reservoir-scale emission rates are often estimated by extrapolating from measurement made at a few locations; however, error and bias associated with this approach can be large and difficult to quantify. Here, we use a generalized random tessellation survey (GRTS) design to generate unbiased estimates of reservoir-CH4 emissions rates (+/- 95% CI) for areas below tributary inflows, open-waters, and at the whole-reservoir scale. Total CH4 emission rates (i.e., sum of ebullition and diffusive emissions) were 4.8 (+/- 2.1), 33.0 (+/- 10.7), and 8.3 (+/- 2.2) mg CH4 m(-2) h(-1) in open-waters, tributary-associated areas, and the whole-reservoir for the period in August 2014 during which 115 sites were sampled across an 7.98 km(2) reservoir in Southwestern, Ohio, U.S.A. Tributary areas occupy 12% of the reservoir surface, but were the source of 41% of total CH4 emissions, highlighting the importance of riverine-lacustrine transition zones. Ebullition accounted for>90% of CH4 emission at all spatial scales. Overall, CH4 emission rates were high for a temperate zone reservoir, possibly because earlier studies underestimated ebullition or did not include emission hot spots. Confidence interval estimates that incorporated spatial pattern in CH4 emissions were up to 29% narrower than when spatial independence is assumed among sites. The use of GRTS, or other probabilistic survey designs, can improve the accuracy and precision of reservoir emission rate estimates, which is needed to better constrain uncertainty in global scale emission estimates. C1 [Beaulieu, Jake J.; Nietch, Christopher T.] US EPA, Natl Risk Management Res Lab, Water Supply & Water Resources Div, Cincinnati, OH 45268 USA. [McManus, Michael G.] US EPA, Natl Ctr Environm Assessment, Biol Assessment Branch, Cincinnati, OH 45268 USA. RP Beaulieu, JJ (reprint author), US EPA, Natl Risk Management Res Lab, Water Supply & Water Resources Div, Cincinnati, OH 45268 USA. EM Beaulieu.jake@epa.gov FU U.S. Environmental Protection Agency, through its Office of Research and Development FX We thank Michelle A. Simon, Mark Martin, Cody Schumacher, Dana Macke, Karen White, Don Brown, and William Wright for field and/or laboratory assistance. We thank Tony Olsen for providing survey design and analysis advice. Anna Springsteen and Stephanie Fitchett with Neptune Inc assisted with portions of the R codes used in the analysis. We also thank two anonymous reviewers for insightful comments on the manuscript. The U.S. Environmental Protection Agency, through its Office of Research and Development, funded and managed the research described herein. It has been subjected to the Agency's administrative review and has been approved for external publication. Any opinions expressed in this article are those of the authors and do not necessarily reflect the views of the Agency, therefore, no official endorsement should be inferred. Any mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 56 TC 1 Z9 1 U1 7 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0024-3590 EI 1939-5590 J9 LIMNOL OCEANOGR JI Limnol. Oceanogr. PD NOV PY 2016 VL 61 SU 1 SI SI BP S27 EP S40 DI 10.1002/lno.10284 PG 14 WC Limnology; Oceanography SC Marine & Freshwater Biology; Oceanography GA ED0VP UT WOS:000388560900003 ER PT J AU Ankley, G Escher, B Hartung, T Shah, I AF Ankley, Gerald Escher, Beate Hartung, Thomas Shah, Imran TI Pathway-Based Approaches for Environmental Monitoring and Risk Assessment SO CHEMICAL RESEARCH IN TOXICOLOGY LA English DT Editorial Material C1 [Ankley, Gerald] Univ Minnesota, Dept Fisheries Wildlife & Conservat Biol, St Paul, MN 55108 USA. [Ankley, Gerald; Shah, Imran] US EPA, Durham, NC 27711 USA. [Escher, Beate] Univ Queensland, Natl Res Ctr Environm Toxicol, Coopers Plains, Qld 4108, Australia. [Hartung, Thomas] Johns Hopkins Univ, Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA. RP Hartung, T (reprint author), 615 N Wolfe St,Room W7035, Baltimore, MD 21205 USA. EM thartun1@jhu.edu RI Escher, Beate/C-7992-2009 OI Escher, Beate/0000-0002-5304-706X NR 1 TC 0 Z9 0 U1 10 U2 10 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0893-228X EI 1520-5010 J9 CHEM RES TOXICOL JI Chem. Res. Toxicol. PD NOV PY 2016 VL 29 IS 11 BP 1789 EP 1790 DI 10.1021/acs.chemrestox.6b00321 PG 2 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology SC Pharmacology & Pharmacy; Chemistry; Toxicology GA ED0QY UT WOS:000388548200001 PM 27933860 ER PT J AU Li, GQ Goldscheider, N Field, MS AF Li, Guangquan Goldscheider, Nico Field, Malcolm S. TI Modeling karst spring hydrograph recession based on head drop at sinkholes SO JOURNAL OF HYDROLOGY LA English DT Article DE Spring discharge; Sinkhole; Exponential recession; Square law; Turbulent flow ID FLORIDAN AQUIFER; CONDUIT-FLOW; GROUNDWATER; RESOURCES; TRANSPORT; MATRIX; SYSTEM; WATER; CAVE AB Spring discharge often responds to rainfall with a rapid increase followed by a slower recession, and the mode of recession is often exponential-like. We propose a new model of the response of spring discharge to rainfall based on the square law for turbulent conduit flow. The new non-exponential model is compared against the exponential model under specific constraints. A hydrograph of St. Marks River in Florida is used to illustrate that when the change in "sinkhole head" (defined as the hydraulic head at the upstream end of the karst conduit connected to the spring) is relatively small, the solution of the new model is close to that of the exponential model, which extends the validity and application of the exponential solution. When the change in sinkhole head is very large, the solutions from the two models clearly differ from each other. Limitations of the non-exponential model are analyzed by simulation of a hydrograph observed downstream of Wakulla Springs. It is concluded that both solutions are applicable when spring response is smaller than or comparable to the base flow, but are nonphysical when the response is much larger than the base discharge. Published by Elsevier B.V. C1 [Li, Guangquan] Yunnan Univ, Dept Geophys, Chenggong Campus, Kunming 650091, Yunnan, Peoples R China. [Goldscheider, Nico] Karlsruhe Inst Technol, Div Hydrogeol, Inst Appl Geosci, D-76131 Karlsruhe, Germany. [Field, Malcolm S.] US EPA, Natl Ctr Environm Assessment 8623P, 1200 Penn Ave N-W, Washington, DC 20460 USA. RP Field, MS (reprint author), US EPA, Natl Ctr Environm Assessment 8623P, 1200 Penn Ave N-W, Washington, DC 20460 USA. EM guangquaru_li@yahoo.com; goldscheider@kit.edu; field.malcolm@epa.gov RI Goldscheider, Nico/A-1780-2017 OI Goldscheider, Nico/0000-0002-8428-5001 FU National Science Foundation of China [41162008] FX Funding support of this study was provided partially by the National Science Foundation of China under Grant 41162008. We thank the Associate Editor assigned to manage this manuscript and the four reviewers for their constructive criticisms and support. NR 29 TC 0 Z9 0 U1 11 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1694 EI 1879-2707 J9 J HYDROL JI J. Hydrol. PD NOV PY 2016 VL 542 BP 820 EP 827 DI 10.1016/j.jhydrol.2016.09.052 PG 8 WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA EC6LU UT WOS:000388248400060 ER PT J AU Wickham, J Nash, MS Barnes, CA AF Wickham, J. Nash, M. S. Barnes, C. A. TI Effect of land cover change on snow free surface albedo across the continental United States SO GLOBAL AND PLANETARY CHANGE LA English DT Article DE Autoregression; Climate change; Cropland; Forest; MODIS; NLCD ID IN-SITU MEASUREMENTS; SCALE DEFORESTATION; CLIMATE MODEL; MODIS; REFLECTANCE; PRODUCTS; DATABASE; FOREST; BRDF; RETRIEVALS AB Land cover changes (e.g., forest to grassland) affect albedo, and changes in albedo can influence radiative forcing (warming, cooling). We empirically tested albedo response to land cover change for 130 locations across the continental United States using high resolution (30 m-x-30 m) land cover change data and moderate resolution (similar to 500 m-x-500 m) albedo data. The land cover change data spanned 10 years (2001 - 2011) and the albedo data included observations every eight days for 13 years (2001 - 2013). Empirical testing was based on autoregressive time series analysis of snow free albedo for verified locations of land cover change. Approximately one-third of the autoregressive analyses for woody to herbaceous or forest to shrub change classes were not significant, indicating that albedo did not change significantly as a result of land cover change at these locations. In addition,similar to 80% of mean differences in albedo arising from land cover change were less than +/- 0.02, a nominal benchmark for precision of albedo measurements that is related to significant changes in radiative forcing. Under snow free conditions, we found that land cover change does not guarantee a significant albedo response, and that the differences in mean albedo response for the majority of land cover change locations were small. Published by Elsevier B.V. C1 [Wickham, J.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Nash, M. S.] US EPA, Off Res & Dev, Las Vegas, NV 89119 USA. [Barnes, C. A.] US Geol Survey, ASRC Fed InuTeq LLC, Earth Resource Observat & Sci EROS Ctr, Sioux Falls, SD 57198 USA. RP Wickham, J (reprint author), US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA. EM wickham.james@epa.gov FU United States Environmental Protection Agency, through its Office of Research and Development; ASRC Federal InuTeq LLC [G13PC00028]; U.S. Geological Survey [G13PC00028] FX The United States Environmental Protection Agency, through its Office of Research and Development, partly funded and managed the research described here. The article has been reviewed by the USEPA's Office of Research and Development and approved for publication. Approval does not signify that the contents reflect the views of the USEPA. C. Barnes' participation was underwritten by contract G13PC00028 between ASRC Federal InuTeq LLC and the U.S. Geological Survey. The authors are grateful for comments on earlier drafts by Dr. Jay Christensen (US EPA), and anonymous reviewers. Use of trade names does not imply endorsement by the U.S. Government. NR 48 TC 0 Z9 0 U1 7 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0921-8181 EI 1872-6364 J9 GLOBAL PLANET CHANGE JI Glob. Planet. Change PD NOV PY 2016 VL 146 BP 1 EP 9 DI 10.1016/j.gloplacha.2016.09.0050 PG 9 WC Geography, Physical; Geosciences, Multidisciplinary SC Physical Geography; Geology GA EC3TR UT WOS:000388049700001 ER PT J AU Wong, H Elleman, R Wolvovsky, E Richmond, K Paumier, J AF Wong, Herman Elleman, Rob Wolvovsky, Eric Richmond, Ken Paumier, James TI AERCOARE: An overwater meteorological preprocessor for AERMOD SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION LA English DT Article ID AIR-SEA FLUXES; BULK PARAMETERIZATION; DISPERSION MODEL; BOUNDARY-LAYER; OCEAN; DEPENDENCE AB AERCOARE is a meteorological data preprocessor for the American Meteorological Society and U.S Environmental Protection Agency (EPA) Regulatory Model (AERMOD). AERCOARE includes algorithms developed during the Coupled-Ocean Atmosphere Response Experiment (COARE) to predict surface energy fluxes and stability from routine overwater measurements. The COARE algorithm is described and the implementation in AERCOARE is presented. Model performance for the combined AERCOARE-AERMOD modeling approach was evaluated against tracer measurements from four overwater field studies. Relatively better model performance was found when lateral turbulence measurements were available and when several key input variables to AERMOD were constrained. Namely, requiring the mixed layer height to be greater than 25 m and not allowing the Monin Obukhov length to be less than 5 m improved model performance in low wind speed stable conditions. Several options for low wind speed dispersion in AERMOD also affected the model performance results. Model performance for the combined AERCOARE-AERMOD modeling approach was found to be comparable to the current EPA regulatory Offshore Coastal Model (OCD) for the same tracer studies. AERCOARE-AERMOD predictions were also compared to simulations using the California Puff-Advection Model (CALPUFF) that also includes the COARE algorithm. Many model performance measures were found to be similar, but CALPUFF had significantly less scatter and better performance for one of the four field studies. For many offshore regulatory applications, the combined AERCOARE-AERMOD modeling approach was found to be a viable alternative to OCD the currently recommended model.Implications: A new meteorological preprocessor called AERCOARE was developed for offshore source dispersion modeling using the U.S. Environmental Protection Agency (EPA) regulatory model AERMOD. The combined AERCOARE-AERMOD modeling approach allows stakeholders to use the same dispersion model for both offshore and onshore applications. This approach could replace current regulatory practices involving two completely different modeling systems. As improvements and features are added to the dispersion model component, AERMOD, such techniques can now also be applied to offshore air quality permitting. C1 [Wong, Herman; Elleman, Rob] US EPA, Reg 10,1200 6th Ave,Suite 900,Mail Stop OERA-140, Seattle, WA 98101 USA. [Wolvovsky, Eric] US Dept Interior, Bur Ocean & Energy Management, Sterling, VA USA. [Richmond, Ken] Ramboll Environ, Seattle, WA USA. [Paumier, James] Amec Foster Wheeler Environm & Infrastruct Inc, Durham, NC USA. RP Elleman, R (reprint author), US EPA, Reg 10,1200 6th Ave,Suite 900,Mail Stop OERA-140, Seattle, WA 98101 USA. EM elleman.robert@epa.gov FU U.S. Department of the Interior, Bureau of Ocean Energy Management, Environmental Studies Program, Washington, D.C.; U.S. Environmental Protection Agency, Region 10, Seattle, Washington FX The studies associated with this work were funded by the U.S. Department of the Interior, Bureau of Ocean Energy Management, Environmental Studies Program, Washington, D.C., and the U.S. Environmental Protection Agency, Region 10, Seattle, Washington. NR 24 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1096-2247 EI 2162-2906 J9 J AIR WASTE MANAGE JI J. Air Waste Manage. Assoc. PD NOV PY 2016 VL 66 IS 11 BP 1121 EP 1140 DI 10.1080/10962247.2016.1202156 PG 20 WC Engineering, Environmental; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA EA7XU UT WOS:000386847000007 PM 27336680 ER PT J AU Varma, RS AF Varma, Rajender S. TI Greener and Sustainable Trends in Synthesis of Organics and Nanomaterials SO ACS SUSTAINABLE CHEMISTRY & ENGINEERING LA English DT Article DE Green chemistry; Magnetic nanocatalysts; Nanomaterials; Organic synthesis; Sustainable processes ID MICROWAVE-ASSISTED SYNTHESIS; SOLVENT-FREE CONDITIONS; MAGNETICALLY RETRIEVABLE CATALYSTS; POLY(VINYL ALCOHOL) NANOCOMPOSITES; AQUEOUS N-HETEROCYCLIZATION; BETA-KETO SULFONES; IONIC LIQUIDS; AMBIENT CONDITIONS; ULTRASOUND IRRADIATION; ASYMMETRIC-SYNTHESIS AB Trends in greener and sustainable process development during the past 25 years are abridged involving the use of alternate energy inputs (mechanochemistry, ultrasound- or microwave irradiation), photochemistry, and greener reaction media as applied to synthesis of organics and nanomaterials. In the organic synthesis arena, examples comprise assembly of heterocyclic compounds, coupling and a variety of other name reactions catalyzed by basic water or recyclable magnetic nanocatalysts. Generation of nanoparticles benefits from the biomimetic approaches where vitamins, sugars, and plant polyphenols, including agricultural waste residues, can serve as reducing and capping agents. Metal nanocatalysts (Pd, Au, Ag, Ni, Ru, Ce, Cu, etc.) immobilized on biodegradable supports such as cellulose and chitosan, or on recyclable magnetic ferrites via ligands, namely dopamine or glutathione, are receiving special attention. These strategic approaches attempt to address most of the Green Chemistry Principles while producing functional chemicals with utmost level of waste minimization. C1 [Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, 26 West MLK Dr,MS 443, Cincinnati, OH 45268 USA. RP Varma, RS (reprint author), US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, 26 West MLK Dr,MS 443, Cincinnati, OH 45268 USA. EM Varma.Rajender@epa.gov NR 124 TC 5 Z9 5 U1 39 U2 39 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2168-0485 J9 ACS SUSTAIN CHEM ENG JI ACS Sustain. Chem. Eng. PD NOV PY 2016 VL 4 IS 11 BP 5866 EP 5878 DI 10.1021/acssuschemeng.6b01623 PG 13 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Chemical SC Chemistry; Science & Technology - Other Topics; Engineering GA EB5PO UT WOS:000387428700007 ER PT J AU Ruiz-Mercado, GJ Carvalho, A Cabezas, H AF Ruiz-Mercado, Gerardo J. Carvalho, Ana Cabezas, Heriberto TI Using Green Chemistry and Engineering Principles To Design, Assess, and Retrofit Chemical Processes for Sustainability SO ACS SUSTAINABLE CHEMISTRY & ENGINEERING LA English DT Article DE Indicators; Process development; WAR algorithm; GREENSCOPE; SustainPro ID REDUCTION WAR ALGORITHM; SOFTWARE TOOL; INDICATORS; ALTERNATIVES; METHODOLOGY; GENERATION AB The concepts of green chemistry and engineering (GC&E) have been promoted as an effective qualitative framework for developing more sustainable chemical syntheses, processes, and material management techniques. This has been demonstrated by many theoretical and practical cases. In addition, there are several approaches and frameworks focused on demonstrating that improvements were achieved through GC&E technologies. However, the application of these principles is not always straightforward. We propose using systematic frameworks and tools that help practitioners when deciding which principles can be applied, the levels of implementation, prospective of obtaining simultaneous improvements in all sustainability aspects, and ways to deal with multiobjective problems. Therefore, this contribution aims to provide a systematic combination of three different and complementary design tools for assisting designers in evaluating, developing, and improving chemical manufacturing and materials management systems under GC&E perspectives. The WAR Algorithm, GREENSCOPE, and SustainPro were employed for this synergistic approach of incorporating sustainability at early stages of process development. In this demonstration, simulated ammonia production is used as a case study to illustrate this advancement. Results show how to identify process design areas for improvements, key factors, multicriteria decision-making solutions, and optimal trade-offs. Finally, conclusions were presented regarding the tools' use in more robust sustainable process and material management designs. C1 [Ruiz-Mercado, Gerardo J.; Cabezas, Heriberto] US EPA, Off Res & Dev, Natl Risk Management Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. [Carvalho, Ana] Univ Lisbon, Inst Super Tecn, CEG IST, Av Rovisco Pais 1, P-1049001 Lisbon, Portugal. RP Cabezas, H (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM cabezas.heriberto@epa.gov OI Carvalho, Ana/0000-0001-7848-7574 NR 29 TC 0 Z9 0 U1 17 U2 17 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2168-0485 J9 ACS SUSTAIN CHEM ENG JI ACS Sustain. Chem. Eng. PD NOV PY 2016 VL 4 IS 11 BP 6208 EP 6221 DI 10.1021/acs.suschemeng.61302200 PG 14 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Chemical SC Chemistry; Science & Technology - Other Topics; Engineering GA EB5PO UT WOS:000387428700048 ER PT J AU Jiao, W Hagler, G Williams, R Sharpe, R Brown, R Garver, D Judge, R Caudill, M Rickard, J Davis, M Weinstock, L Zimmer-Dauphinee, S Buckley, K AF Jiao, Wan Hagler, Gayle Williams, Ronald Sharpe, Robert Brown, Ryan Garver, Daniel Judge, Robert Caudill, Motria Rickard, Joshua Davis, Michael Weinstock, Lewis Zimmer-Dauphinee, Susan Buckley, Ken TI Community Air Sensor Network (CAIRSENSE) project: evaluation of low-cost sensor performance in a suburban environment in the southeastern United States SO ATMOSPHERIC MEASUREMENT TECHNIQUES LA English DT Article ID DENSITY NETWORKS; NITROGEN-DIOXIDE; POLLUTION; QUALITY AB Advances in air pollution sensor technology have enabled the development of small and low-cost systems to measure outdoor air pollution. The deployment of a large number of sensors across a small geographic area would have potential benefits to supplement traditional monitoring networks with additional geographic and temporal measurement resolution, if the data quality were sufficient. To understand the capability of emerging air sensor technology, the Community Air Sensor Network (CAIRSENSE) project deployed low-cost, continuous, and commercially available air pollution sensors at a regulatory air monitoring site and as a local sensor network over a surrounding similar to 2 km area in the southeastern United States. Collocation of sensors measuring oxides of nitrogen, ozone, carbon monoxide, sulfur dioxide, and particles revealed highly variable performance, both in terms of comparison to a reference monitor as well as the degree to which multiple identical sensors produced the same signal. Multiple ozone, nitrogen dioxide, and carbon monoxide sensors revealed low to very high correlation with a reference monitor, with Pearson sample correlation coefficient (r) ranging from 0.39 to 0.97, 0.25 to 0.76, and 0.40 to 0.82, respectively. The only sulfur dioxide sensor tested revealed no correlation (r < 0.5) with a reference monitor and erroneously high concentration values. A wide variety of particulate matter (PM) sensors were tested with variable results - some sensors had very high agreement (e.g., r = 0.99) between identical sensors but moderate agreement with a reference PM2.5 monitor (e.g., r = 0.65). For select sensors that had moderate to strong correlation with reference monitors (r > 0.5), step-wise multiple linear regression was performed to determine if ambient temperature, relative humidity (RH), or age of the sensor in number of sampling days could be used in a correction algorithm to improve the agreement. Maximum improvement in agreement with a reference, incorporating all factors, was observed for an NO2 sensor (multiple correlation coefficient R-adj-orig(2) = 0.57, R-adj-final(2) = 0.81); however, other sensors showed no apparent improvement in agreement. A four-node sensor network was successfully able to capture ozone (two nodes) and PM (four nodes) data for an 8-month period of time and show expected diurnal concentration patterns, as well as potential ozone titration due to nearby traffic emissions. Overall, this study demonstrates the performance of emerging air quality sensor technologies in a real-world setting; the variable agreement between sensors and reference monitors indicates that in situ testing of sensors against benchmark monitors should be a critical aspect of all field studies. C1 [Jiao, Wan; Hagler, Gayle; Williams, Ronald] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Sharpe, Robert] ARCADIS US Inc, Durham, NC 27713 USA. [Brown, Ryan; Garver, Daniel] US EPA, Reg 4, Atlanta, GA 30303 USA. [Judge, Robert] US EPA, Reg 1, Boston, MA 02109 USA. [Caudill, Motria] US EPA, Reg 5, Chicago, IL 60604 USA. [Rickard, Joshua] US EPA, Reg 8, Denver, CO 80202 USA. [Davis, Michael] US EPA, Reg 7, Lenexa, KS 66219 USA. [Weinstock, Lewis] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA. [Zimmer-Dauphinee, Susan; Buckley, Ken] Georgia Environm Protect Div, Atlanta, GA 30354 USA. RP Hagler, G (reprint author), US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA. EM hagler.gayle@epa.gov FU US Environmental Protection Agency through Office of Research and Development FX The US Environmental Protection Agency through it Office of Research and Development funded and conducted the research described here. Mention of trade names or commercial products does not constitute endorsement or recommendations for use. Although this work was reviewed by EPA and approved for publication, it may not necessarily reflect official agency policy. NR 17 TC 0 Z9 0 U1 14 U2 14 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1867-1381 EI 1867-8548 J9 ATMOS MEAS TECH JI Atmos. Meas. Tech. PD NOV 1 PY 2016 VL 9 IS 11 BP 5281 EP 5292 DI 10.5194/amt-9-5281-2016 PG 12 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA EB1MJ UT WOS:000387116100001 ER PT J AU Deemer, BR Harrison, JA Li, SY Beaulieu, JJ Delsontro, T Barros, N Bezerra-Neto, JF Powers, SM dos Santos, MA Vonk, JA AF Deemer, Bridget R. Harrison, John A. Li, Siyue Beaulieu, Jake J. Delsontro, Tonya Barros, Nathan Bezerra-Neto, Jose F. Powers, Stephen M. dos Santos, Marco A. Vonk, J. Arie TI Greenhouse Gas Emissions from Reservoir Water Surfaces: A New Global Synthesis SO BIOSCIENCE LA English DT Article DE reservoir; methane; greenhouse gas; eutrophication; ebullition ID COVARIANCE FLUX MEASUREMENTS; CARBON-DIOXIDE; HYDROELECTRIC RESERVOIRS; METHANE EMISSIONS; NITROUS-OXIDE; CH4 EMISSIONS; BOREAL LAKES; SPATIAL HETEROGENEITY; HYDROPOWER RESERVOIR; TROPICAL HYDROPOWER AB Collectively, reservoirs created by dams are thought to be an important source of greenhouse gases (GHGs) to the atmosphere. So far, efforts to quantify, model, and manage these emissions have been limited by data availability and inconsistencies in methodological approach. Here, we synthesize reservoir CH4, CO2, and N2O emission data with three main objectives: (1) to generate a global estimate of GHG emissions from reservoirs, (2) to identify the best predictors of these emissions, and (3) to consider the effect of methodology on emission estimates. We estimate that GHG emissions from reservoir water surfaces account for 0.8 (0.5-1.2) Pg CO2 equivalents per year, with the majority of this forcing due to CH4. We then discuss the potential for several alternative pathways such as dam degassing and downstream emissions to contribute significantly to overall emissions. Although prior studies have linked reservoir GHG emissions to reservoir age and latitude, we find that factors related to reservoir productivity are better predictors of emission. C1 [Deemer, Bridget R.; Harrison, John A.] Washington State Univ, Sch Environm, Vancouver, WA USA. [Li, Siyue] Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing, Peoples R China. [Beaulieu, Jake J.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. [Beaulieu, Jake J.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Delsontro, Tonya] Univ Quebec, Dept Biol Sci, Montreal, PQ, Canada. [Delsontro, Tonya] Swiss Fed Inst Aquat Sci & Technol Eawag, Kastanienbaum, Switzerland. [Barros, Nathan] Univ Fed Juiz de Fora, Inst Biol Sci, Juiz De Fora, MG, Brazil. [Bezerra-Neto, Jose F.] Univ Fed Minas Gerais, Inst Biol Sci, Belo Horizonte, MG, Brazil. [Powers, Stephen M.] Washington State Univ, Sch Environm, Pullman, WA 99164 USA. [Powers, Stephen M.] Washington State Univ, Ctr Environm Res Educ & Outreach, Pullman, WA 99164 USA. [dos Santos, Marco A.] Univ Fed Rio de Janeiro, Energy Planning Program, COPPE, BR-21941 Rio De Janeiro, Brazil. [dos Santos, Marco A.] Univ Fed Rio de Janeiro, Ctr Tecnol, BR-21941 Rio De Janeiro, Brazil. [Vonk, J. Arie] Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, Dept Aquat Environm Ecol, NL-1012 WX Amsterdam, Netherlands. RP Deemer, BR (reprint author), Washington State Univ, Sch Environm, Vancouver, WA USA. EM bdeemer@wsu.edu RI Vonk, Jan Arie/B-1105-2009; OI Vonk, Jan Arie/0000-0002-8803-1148; Deemer, Bridget/0000-0002-5845-1002 FU Hundred Talent Program of the Chinese Academy of Sciences; National Natural Science Foundation of China [NSFC 31670473]; European Research Council under the European Union's Seventh Framework Programme [FP7/2007-2013]; ERC [336642]; CNPq/Brazil fellowship [202937/2014-3]; US Army Corps of Engineers Climate Preparedness and Resilience Programs; National Science Foundation (NSF) DEB Grant [135211]; US Environmental Protection Agency STAR Fellowship [FP917450]; NSF IGERT Fellowship [0903714] FX This synthesis benefitted from supplemental data graciously provided by Huai Chen, Pierre-Andre Jacinthe, Yang Meng, Yu-Hsuan Wang, and Christiane Zarfl. We also appreciate the helpful input provided by David Bastviken, M. Keith Birchfield, Amy Burgin, Will Forney, Frederic Guerin, Lesley Knoll, Andreas Maeck, Rebecca Martin, John Melack, Genevieve Metson, Cody Miller, Reed Norton, Dan Reed, Katrin Sturm, Alain Tremblay, and Yan Zhao. Funding was provided by the Hundred Talent Program of the Chinese Academy of Sciences and the National Natural Science Foundation of China (NSFC 31670473) to Li, the European Research Council under the European Union's Seventh Framework Programme (no. FP7/2007-2013) and ERC agreement no. 336642 to Barros, the CNPq/Brazil fellowship 202937/2014-3 to Bezerra-Neto, US Army Corps of Engineers Climate Preparedness and Resilience Programs and National Science Foundation (NSF) DEB Grant no. 135211 to Harrison, and US Environmental Protection Agency STAR Fellowship no. FP917450 and NSF IGERT Fellowship no. 0903714 to Deemer. NR 96 TC 1 Z9 1 U1 48 U2 48 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0006-3568 EI 1525-3244 J9 BIOSCIENCE JI Bioscience PD NOV PY 2016 VL 66 IS 11 BP 949 EP 964 DI 10.1093/biosci/biw117 PG 16 WC Biology SC Life Sciences & Biomedicine - Other Topics GA EB6AU UT WOS:000387463900007 ER PT J AU Herrmann, DL Schwarz, K Shuster, WD Berland, A Chaffin, BC Garmestani, AS Hopton, ME AF Herrmann, Dustin L. Schwarz, Kirsten Shuster, William D. Berland, Adam Chaffin, Brian C. Garmestani, Ahjond S. Hopton, Matthew E. TI Ecology for the Shrinking City SO BIOSCIENCE LA English DT Article DE sustainability; urban ecology; shrinking city; amenity; ecosystem services ID URBAN SHRINKAGE; ADAPTIVE GOVERNANCE; ECOSYSTEM SERVICES; UNITED-STATES; CITIES; CHALLENGES; RESILIENCE; MANAGEMENT; SYSTEMS; DESIGN AB This article brings together the concepts of shrinking cities-the hundreds of cities worldwide experiencing long-term population loss-and ecology for the city. Ecology for the city is the application of a social-ecological understanding to shaping urban form and function along sustainable trajectories. Ecology for the shrinking city therefore acknowledges that urban transformations to sustainable trajectories may be quite different in shrinking cities as compared with growing cities. Shrinking cities are well poised for transformations, because shrinking is perceived as a crisis and can mobilize the social capacity to change. Ecology is particularly well suited to contribute solutions because of the extent of vacant land in shrinking cities that can be leveraged for ecosystem-services provisioning. A crucial role of an ecology for the shrinking city is identifying innovative pathways that create locally desired amenities that provide ecosystem services and contribute to urban sustainability at multiple scales. C1 [Herrmann, Dustin L.] US EPA, Oak Ridge Inst Sci & Educ Res Participant Program, Cincinnati, OH 45268 USA. [Schwarz, Kirsten] Northern Kentucky Univ, Dept Biol Sci, Highland Hts, KY USA. [Shuster, William D.; Garmestani, Ahjond S.; Hopton, Matthew E.] US EPA, Natl Risk Management Lab, Cincinnati, OH 45268 USA. [Berland, Adam] Ball State Univ, Dept Geog, Muncie, IN 47306 USA. [Chaffin, Brian C.] Univ Montana, Coll Forestry & Conservat, Missoula, MT 59812 USA. RP Herrmann, DL (reprint author), US EPA, Oak Ridge Inst Sci & Educ Res Participant Program, Cincinnati, OH 45268 USA. EM herrmann.dustin@epa.gov OI Hopton, Matt/0000-0001-7962-6820; Berland, Adam/0000-0003-0473-6405 FU US Environmental Protection Agency (EPA) FX Partial support was provided to DLH through an appointment to the research participation program with the Oak Ridge Institute for Science and Education through the US Department of Energy and the US Environmental Protection Agency (EPA). NR 48 TC 2 Z9 2 U1 21 U2 21 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0006-3568 EI 1525-3244 J9 BIOSCIENCE JI Bioscience PD NOV PY 2016 VL 66 IS 11 BP 965 EP 973 DI 10.1093/biosci/biw062 PG 9 WC Biology SC Life Sciences & Biomedicine - Other Topics GA EB6AU UT WOS:000387463900008 ER PT J AU Helfand, G McWilliams, M Bolon, K Reichle, L Sha, M Smith, A Beach, R AF Helfand, Gloria McWilliams, Michael Bolon, Kevin Reichle, Lawrence Sha, Mandy Smith, Amanda Beach, Robert TI Searching for hidden costs: A technology-based approach to the energy efficiency gap in light-duty vehicles SO ENERGY POLICY LA English DT Article DE Energy efficiency gap; Energy paradox; Light-duty vehicles; Content analysis; Vehicle fuel efficiency; Vehicle greenhouse gas standards ID FUEL-ECONOMY; PRICES AB The benefit-cost analysis of standards to reduce vehicle greenhouse gas emissions and improve fuel economy by the U.S. Environmental Protection Agency (EPA) and the Department of Transportation (DOT) displays large net benefits from fuel savings for new vehicle buyers. This finding points to an energy efficiency gap: the energy-saving technology provided in private markets appears not to include all the technologies that produce net private benefits. The gap exists if the costs of energy-saving technologies are lower than the present value of fuel reductions, and "hidden costs"- undesirable aspects of the new technologies - do not exceed the net financial benefits. This study examines the existence of hidden costs in energy-saving technologies through a content analysis of auto reviews of model-year 2014 vehicles. Results suggest that it is possible to use fuel-saving technologies on vehicles without imposing hidden costs. For each technology examined, reviews with positive evaluations outnumbered those with negative evaluations. Evidence is scant of a robust relationship between vehicles' use of energy-saving technologies and negatively rated operational characteristics, such as handling or acceleration. Results do not provide evidence for hidden costs as the explanation of the efficiency gap for vehicle fuel-saving technologies. Published by Elsevier Ltd. C1 [Helfand, Gloria; Bolon, Kevin] US EPA, Assessment & Stand Div, Off Transportat & Air Qual, 2000 Traverwood Dr, Ann Arbor, MI 48105 USA. [McWilliams, Michael; Reichle, Lawrence] US EPA, Oak Ridge Inst Sci & Educ, Off Transportat & Air Qual, 2000 Traverwood Dr, Ann Arbor, MI 48105 USA. [Sha, Mandy; Smith, Amanda; Beach, Robert] RTI Int, 3040 E Cornwallis Rd, Res Triangle Pk, NC 27709 USA. RP Helfand, G (reprint author), US EPA, Assessment & Stand Div, Off Transportat & Air Qual, 2000 Traverwood Dr, Ann Arbor, MI 48105 USA. EM helfand.gloria@epa.gov FU EPA [EP-C-11-045, WA 3-01] FX RTI International conducted the content analysis under EPA contract EP-C-11-045, WA 3-01. We thank Catherine Hausman, John German, Ann Wolverton, Elizabeth Kopits, two anonymous reviewers, seminar participants at the Lawrence Berkeley National Laboratory, Western Michigan University, the 2015 Summer AERE conference, and the 2015 TE3 Conference at the University of Michigan, and commenters at the EPA's Office of Transportation and Air Quality and the National Highway Traffic Safety Administration for helpful thoughts and discussions. NR 35 TC 0 Z9 0 U1 3 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0301-4215 EI 1873-6777 J9 ENERG POLICY JI Energy Policy PD NOV PY 2016 VL 98 SI SI BP 590 EP 606 DI 10.1016/j.enpol.2016.09.014 PG 17 WC Energy & Fuels; Environmental Sciences; Environmental Studies SC Energy & Fuels; Environmental Sciences & Ecology GA EB3WS UT WOS:000387300300057 ER PT J AU Boehm, AB Wang, D Ercumen, A Shea, M Harris, AR Shanks, OC Kelty, C Ahmed, A Mahmud, ZH Arnold, BF Chase, C Kullmann, C Colford, JM Luby, SP Pickering, AJ AF Boehm, Alexandria B. Wang, Dan Ercumen, Ayse Shea, Meghan Harris, Angela R. Shanks, Orin C. Kelty, Catherine Ahmed, Alvee Mahmud, Zahid Hayat Arnold, Benjamin F. Chase, Claire Kullmann, Craig Colford, John M., Jr. Luby, Stephen P. Pickering, Amy J. TI Occurrence of Host-Associated Fecal Markers on Child Hands, Household Soil, and Drinking Water in Rural Bangladeshi Households SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS LA English DT Article ID REAL-TIME PCR; MICROBIAL SOURCE TRACKING; CLUSTER-RANDOMIZED-TRIAL; DEVELOPING-COUNTRIES; QUANTITATIVE PCR; GENETIC-MARKERS; INDICATOR BACTERIA; SANITATION INTERVENTION; ENVIRONMENTAL WATERS; SEWAGE POLLUTION AB We evaluated whether provision and promotion of improved sanitation hardware (toilets and child feces management tools) reduced rotavirus and human fecal contamination of drinking water, child hands, and soil among rural Bangladeshi compounds enrolled in a cluster-randomized trial. We also measured host-associated genetic markers of ruminant and avian feces. We found evidence of widespread ruminant and avian fecal contamination in the compound environment; non-human fecal marker occurrence scaled with animal ownership. Strategies for controlling non-human fecal waste should be considered when designing interventions to reduce exposure to fecal contamination in low-income settings. Detection of a human associated fecal marker and rotavirus was rare and unchanged by provision and promotion of improved sanitation to intervention compounds. The sanitation intervention reduced ruminant fecal contamination in drinking water and general (non-host specific) fecal contamination in soil but overall had limited effects on reducing fecal contamination in the household environment. C1 [Boehm, Alexandria B.; Wang, Dan; Shea, Meghan; Harris, Angela R.; Pickering, Amy J.] Stanford Univ, Dept Civil & Environm Engn, Stanford, CA 94305 USA. [Ercumen, Ayse; Arnold, Benjamin F.; Colford, John M., Jr.] Univ Calif Berkeley, Div Epidemiol, Berkeley, CA 94720 USA. [Shanks, Orin C.; Kelty, Catherine] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. [Ahmed, Alvee; Mahmud, Zahid Hayat] Int Ctr Diarrheal Dis Res, Dhaka 1000, Bangladesh. [Chase, Claire; Kullmann, Craig] World Bank, Washington, DC 20433 USA. [Luby, Stephen P.; Pickering, Amy J.] Stanford Univ, Woods Inst Environm, Stanford, CA 94305 USA. RP Pickering, AJ (reprint author), Stanford Univ, Dept Civil & Environm Engn, Stanford, CA 94305 USA.; Pickering, AJ (reprint author), Stanford Univ, Woods Inst Environm, Stanford, CA 94305 USA. EM amyjanel@gmail.com RI Wang, Dan/D-3927-2017 FU World Bank; Bill & Melinda Gates Foundation [OPPGD759] FX Information has been subjected to U.S. Environmental Protection Agency (USEPA) peer and administrative review and has been approved for external publication. This research was financially supported by the World Bank and in part by Grant OPPGD759 from the Bill & Melinda Gates Foundation to the University of California, Berkeley. We thank Leanne Unicomb, Masud Parvez, and Solaiman Abeer. NR 47 TC 0 Z9 0 U1 9 U2 9 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2328-8930 J9 ENVIRON SCI TECH LET JI Environ. Sci. Technol. Lett. PD NOV PY 2016 VL 3 IS 11 BP 393 EP 398 DI 10.1021/acs.estlett.6b00382 PG 6 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA EB6XF UT WOS:000387528200003 ER PT J AU Pleil, KE Helms, CM Sobus, JR Daunais, JB Grant, KA Kash, TL AF Pleil, Kristen E. Helms, Christa M. Sobus, Jon R. Daunais, James B. Grant, Kathleen A. Kash, Thomas L. TI Effects of chronic alcohol consumption on neuronal function in the non-human primate BNST SO ADDICTION BIOLOGY LA English DT Article DE bed nucleus of the stria terminalis; electrophysiology; glucocorticoids; HPA axis; rhesus monkey; stress hormones; synaptic transmission ID CORTICOTROPIN-RELEASING-FACTOR; PITUITARY-ADRENAL AXIS; STRIA TERMINALIS; BED NUCLEUS; EXTENDED AMYGDALA; DEHYDROEPIANDROSTERONE-SULFATE; ETHANOL WITHDRAWAL; GABA(A) RECEPTOR; DEPENDENT RATS; MESSENGER-RNA AB Alterations in hypothalamic-pituitary-adrenal axis function contribute to many of the adverse behavioral effects of chronic voluntary alcohol drinking, including alcohol dependence and mood disorders; limbic brain structures such as the bed nucleus of the stria terminalis (BNST) may be key sites for these effects. Here, we measured circulating levels of several steroid hormones and performed whole-cell electrophysiological recordings from acutely prepared BNST slices of male rhesus monkeys allowed to self-administer alcohol for 12months or a control solution. Initial comparisons revealed that BNST neurons in alcohol-drinking monkeys had decreased membrane resistance, increased frequency of spontaneous inhibitory postsynaptic currents (sIPSCs) with no change in spontaneous excitatory postsynaptic currents (sEPSCs). We then used a combined variable cluster analysis and linear mixed model statistical approach to determine whether specific factors including stress and sex hormones, age and measures of alcohol consumption and intoxication are related to these BNST measures. Modeling results showed that specific measures of alcohol consumption and stress-related hormone levels predicted differences in membrane conductance in BNST neurons. Distinct groups of adrenal stress hormones were negatively associated with the frequency of sIPSCs and sEPSCs, and alcohol drinking measures and basal neuronal membrane properties were additional positive predictors of inhibitory, but not excitatory, PSCs. The amplitude of sEPSCs was highly positively correlated with age, independent of other variables. Together, these results suggest that chronic voluntary alcohol consumption strongly influences limbic function in non-human primates, potentially via interactions with or modulation by other physiological variables, including stress steroid hormones and age. C1 [Pleil, Kristen E.; Kash, Thomas L.] Univ North Carolina Chapel Hill, Bowles Ctr Alcohol Studies, Chapel Hill, NC USA. [Pleil, Kristen E.; Kash, Thomas L.] Univ North Carolina Chapel Hill, Sch Med, Dept Pharmacol, Chapel Hill, NC USA. [Helms, Christa M.; Grant, Kathleen A.] Oregon Hlth & Sci Univ, Oregon Natl Primate Res Ctr, Div Neurosci, Beaverton, OR USA. [Sobus, Jon R.] US EPA, Human Exposure & Atmospher Sci Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Daunais, James B.] Wake Forest Sch Med, Dept Physiol & Pharmacol, Winston Salem, NC USA. RP Kash, TL (reprint author), 104 Manning Dr,Thurston Bowles Bldg,CB 7178, Chapel Hill, NC 27599 USA. EM tkash@email.unc.edu FU NIH [F32 AA021043, K99 AA023599, U01 AA020911]; Bowles Center for Alcohol Studies [U01 AA013510, R24 AA019431]; Oregon National Primate Research Center [P51 OD011092] FX We would like to thank Matthew Stiegel and Joachim Pleil for assistance with statistical analyses. NIH grant support for this research was provided by F32 AA021043 and K99 AA023599 (KEP), U01 AA020911 (TLK), the Bowles Center for Alcohol Studies (KEP and TLK), U01 AA013510 (KAG and CMH), R24 AA019431 (JBD, KAG and CMH), and the Oregon National Primate Research Center grant P51 OD011092 (KAG and CMH). NR 78 TC 1 Z9 1 U1 4 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1355-6215 EI 1369-1600 J9 ADDICT BIOL JI Addict. Biol. PD NOV PY 2016 VL 21 IS 6 BP 1151 EP 1167 DI 10.1111/adb.12289 PG 17 WC Biochemistry & Molecular Biology; Substance Abuse SC Biochemistry & Molecular Biology; Substance Abuse GA EA9NX UT WOS:000386972100008 PM 26223349 ER PT J AU Cote, I Andersen, ME Ankley, GT Barone, S Birnbaum, LS Boekelheide, K Bois, F Burgoon, LD Chiu, WA Crawford-Brown, D Crofton, KM DeVito, M Devlin, RB Edwards, SW Guyton, KZ Hattis, D Judson, RS Knight, D Krewski, D Lambert, J Maull, EA Mendrick, D Paoli, GM Patel, CJ Perkins, EJ Poje, G Portier, CJ Rusyn, I Schulte, PA Simeonov, A Smith, MT Thayer, KA Thomas, RS Thomas, R Tice, RR Vandenberg, JJ Villeneuve, DL Wesselkamper, S Whelan, M Whittaker, C White, R Xia, M Yauk, C Zeise, L Zhao, J DeWoskin, RS AF Cote, Ila Andersen, Melvin E. Ankley, Gerald T. Barone, Stanley Birnbaum, Linda S. Boekelheide, Kim Bois, FredericY. Burgoon, Lyle D. Chiu, Weihsueh A. Crawford-Brown, Douglas Crofton, Kevin M. DeVito, Michael Devlin, Robert B. Edwards, Stephen W. Guyton, Kathryn Z. Hattis, Dale Judson, Richard S. Knight, Derek Krewski, Daniel Lambert, Jason Maull, Elizabeth Anne Mendrick, Donna Paoli, Gregory M. Patel, Chirag Jagdish Perkins, Edward J. Poje, Gerald Portier, Christopher J. Rusyn, Ivan Schulte, Paul A. Simeonov, Anton Smith, Martyn T. Thayer, Kristina A. Thomas, Russell S. Thomas, Reuben Tice, Raymond R. Vandenberg, John J. Villeneuve, Daniel L. Wesselkamper, Scott Whelan, Maurice Whittaker, Christine White, Ronald Xia, Menghang Yauk, Carole Zeise, Lauren Zhao, Jay DeWoskin, Robert S. TI The Next Generation of Risk Assessment Multi-Year Study-Highlights of Findings, Applications to Risk Assessment, and Future Directions SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Review ID ADVERSE OUTCOME PATHWAYS; BRONCHIAL EPITHELIAL-CELLS; THROUGHPUT SCREENING DATA; IN-VIVO HAZARD; ENVIRONMENTAL CHEMICALS; HUMAN HEALTH; GENE-EXPRESSION; POPULATION VARIABILITY; PREDICTIVE TOXICOLOGY; ESTROGEN-RECEPTOR AB BACKGROUND: The Next Generation (NexGen) of Risk Assessment effort is a multi-year collaboration among several organizations evaluating new, potentially more efficient molecular, computational, and systems biology approaches to risk assessment. This article summarizes our findings, suggests applications to risk assessment, and identifies strategic research directions. OBJECTIVE: Our specific objectives were to test whether advanced biological data and methods could better inform our understanding of public health risks posed by environmental exposures. METHODS: New data and methods were applied and evaluated for use in hazard identification and dose-response assessment. Biomarkers of exposure and effect, and risk characterization were also examined. Consideration was given to various decision contexts with increasing regulatory and public health impacts. Data types included transcriptomics, genomics, and proteomics. Methods included molecular epidemiology and clinical studies, bioinformatic knowledge mining, pathway and network analyses, short-duration in vivo and in vitro bioassays, and quantitative structure activity relationship modeling. DISCUSSION: NexGen has advanced our ability to apply new science by more rapidly identifying chemicals and exposures of potential concern, helping characterize mechanisms of action that influence conclusions about causality, exposure-response relationships, susceptibility and cumulative risk, and by elucidating new biomarkers of exposure and effects. Additionally, NexGen has fostered extensive discussion among risk scientists and managers and improved confidence in interpreting and applying new data streams. CONCLUSIONS: While considerable uncertainties remain, thoughtful application of new knowledge to risk assessment appears reasonable for augmenting major scope assessments, forming the basis for or augmenting limited scope assessments, and for prioritization and screening of very data limited chemicals. C1 [Cote, Ila; Vandenberg, John J.; DeWoskin, Robert S.] US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA. [Andersen, Melvin E.] ScitoVation, Res Triangle Pk, NC USA. [Ankley, Gerald T.; Villeneuve, Daniel L.] US EPA, Natl Hlth & Environm Effects Res Lab, Duluth, MN USA. [Barone, Stanley] US EPA, Off Chem Safety & Pollut Prevent, Washington, DC 20460 USA. [Birnbaum, Linda S.; DeVito, Michael; Maull, Elizabeth Anne; Thayer, Kristina A.; Tice, Raymond R.] NIEHS, POB 12233, Res Triangle Pk, NC 27709 USA. [Birnbaum, Linda S.; DeVito, Michael; Maull, Elizabeth Anne; Thayer, Kristina A.; Tice, Raymond R.] NIH, Natl Toxicol Program, DHHS, Res Triangle Pk, NC USA. [Boekelheide, Kim] Brown Univ, Dept Pathol & Lab Med, Providence, RI 02912 USA. [Bois, FredericY.] Inst Natl Environm Ind & Risques, Unite Modeles Icotoxicol & Toxicol, Verneuil En Halatte, France. [Burgoon, Lyle D.] US Army, Engineer Res & Dev Ctr, Res Triangle Pk, NC USA. [Chiu, Weihsueh A.; Rusyn, Ivan] Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Vet Integrat Biosci, College Stn, TX USA. [Crawford-Brown, Douglas] Univ Cambridge, Dept Land Econ, Cambridge, England. [Crofton, Kevin M.; Judson, Richard S.; Thomas, Russell S.] Natl Ctr Computat Toxicol, Res Triangle Pk, NC USA. [Devlin, Robert B.; Edwards, Stephen W.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Guyton, Kathryn Z.] Int Agcy Res Canc, Lyon, France. [Hattis, Dale] Clark Univ, George Perkins Marsh Inst, Worcester, MA 01610 USA. [Knight, Derek] European Chem Agcy, Helsinki, Finland. [Krewski, Daniel] Univ Ottawa, McLaughlin Ctr Populat Hlth Risk Assessment, Ottawa, ON, Canada. [Lambert, Jason; Wesselkamper, Scott; Zhao, Jay] US EPA, Natl Ctr Environm Assessment, Cincinnati, OH 45268 USA. [Mendrick, Donna] US FDA, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA. [Paoli, Gregory M.] Risk Sci Int, Ottawa, ON, Canada. [Patel, Chirag Jagdish] Harvard Med Sch, Dept Biomed Informat, Boston, MA USA. [Perkins, Edward J.] US Army, Engineer Res & Dev Ctr, Vicksburg, MS USA. [Poje, Gerald] Grant Consulting Grp, Washington, DC USA. [Portier, Christopher J.] Environm Def Fund, Washington, DE USA. [Schulte, Paul A.; Whittaker, Christine] Ctr Dis Control & Prevent, Natl Inst Occupat Safety & Hlth, Educ & Informat Div, Cincinnati, OH USA. [Simeonov, Anton; Xia, Menghang] NIH, Natl Ctr Adv Translat Sci, DHHS, Bethesda, MD USA. [Smith, Martyn T.] Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA. [Thomas, Reuben] Univ Calif San Francisco, Gladstone Inst, San Francisco, CA 94143 USA. [Whelan, Maurice] European Commiss Joint Res Ctr, Syst Toxicol Unit, Ispra, Italy. [White, Ronald] Ctr Effect Govt, Washington, DE USA. [Yauk, Carole] Hlth Canada, Environm Hlth Sci & Res Bur, Ottawa, ON, Canada. [Zeise, Lauren] Calif EPA, Off Environm Hlth Hazard Assessment, Oakland, CA USA. RP Cote, I (reprint author), US EPA, Reg 8,Room 8152,1595 Wynkoop St, Denver, CO 80202 USA. EM cote.ila@epa.gov RI Bois, Frederic/E-9241-2012; Rusyn, Ivan/S-2426-2016; OI Bois, Frederic/0000-0002-4154-0391; Vandenberg, John/0000-0003-2619-9460; Burgoon, Lyle/0000-0003-4977-5352 FU NIEHS NIH HHS [P42 ES005948, R00 ES023504, K99 ES023504, R21 ES025052] NR 152 TC 0 Z9 0 U1 30 U2 30 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD NOV PY 2016 VL 124 IS 11 BP 1671 EP 1682 DI 10.1289/EHP233 PG 12 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA EA8UF UT WOS:000386913800010 PM 27091369 ER PT J AU Parks, CG Hoppin, JA De Roos, AJ Costenbader, KH Alavanja, MC Sandler, DP AF Parks, Christine G. Hoppin, Jane A. De Roos, Anneclaire J. Costenbader, Karen H. Alavanja, Michael C. Sandler, Dale P. TI Rheumatoid Arthritis in Agricultural Health Study Spouses: Associations with Pesticides and Other Farm Exposures SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; EXPERT PANEL WORKSHOP; AUTOIMMUNE-DISEASES; IN-VITRO; ENVIRONMENTAL EXPOSURES; OCCUPATIONAL EXPOSURES; UNITED-STATES; NURSES HEALTH; WOMEN; RISK AB BACKGROUND: Farming has been associated with rheumatoid arthritis (RA), but the role of pesticides is not known. OBJECTIVES: We examined associations between RA and pesticides or other agricultural exposures among female spouses of licensed pesticide applicators in the Agricultural Health Study. METHODS: Women were enrolled between 1993 and 1997 and followed through 2010. Cases (n=275 total, 132 incident), confirmed by a physician or by self-reported use of disease modifying antirheumatic drugs, were compared with noncases (n=24,018). Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models adjusted for age, state, and smoking pack-years. RESULTS: Overall, women with RA were somewhat more likely to have reported lifetime use of any specific pesticide versus no pesticides (OR=1.4; 95% CI: 1.0, 1.6). Of the 15 pesticides examined, maneb/mancozeb (OR=3.3; 95% CI: 1.5, 7.1) and glyphosate (OR=1.4; 95% CI: 1.0, 2.1) were associated with incident RA compared with no pesticide use. An elevated, but non-statistically significant association with incident RA was seen for DDT (OR=1.9; 95% CI: 0.97, 3.6). Incident RA was also associated with the application of chemical fertilizers (OR=1.7; 95% CI: 1.1, 2.7) and cleaning with solvents (OR=1.6; 95% CI: 1.1, 2.4), but inversely associated with lifetime livestock exposure as a child and adult (OR=0.48; 95% CI: 0.24, 0.97) compared with no livestock exposure. CONCLUSIONS: Our results suggest that specific agricultural pesticides, solvents, and chemical fertilizers may increase the risk of RA in women, while exposures involving animal contact may be protective. C1 [Parks, Christine G.; Sandler, Dale P.] Natl Inst Environm Hlth Sci, Epidemiol Branch, NIH, DHHS, Res Triangle Pk, NC USA. [Hoppin, Jane A.] North Carolina State Univ, Dept Biol Sci, Ctr Human Hlth & Environm, Raleigh, NC 27695 USA. [De Roos, Anneclaire J.] Drexel Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, Philadelphia, PA 19104 USA. [Costenbader, Karen H.] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA USA. [Alavanja, Michael C.] NCI, Div Canc Epidemiol & Genet, NIH, DHHS, Bethesda, MD USA. RP Parks, CG (reprint author), NIEHS, Epidemiol Branch, A3-05,POB 12233, Res Triangle Pk, NC 27599 USA. EM Parks1@mail.nih.gov OI Parks, Christine/0000-0002-5734-3456; Sandler, Dale/0000-0002-6776-0018 FU Intramural Research Program of the National Institutes of Health (NIH), National Institute of Environmental Health Sciences [Z01-ES049030]; National Cancer Institute/NIH [Z01-CP010119] FX This work was supported by the Intramural Research Program of the National Institutes of Health (NIH), National Institute of Environmental Health Sciences (Z01-ES049030) and National Cancer Institute/NIH (Z01-CP010119). NR 53 TC 0 Z9 0 U1 5 U2 5 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD NOV PY 2016 VL 124 IS 11 BP 1728 EP 1734 DI 10.1289/EHP129 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA EA8UF UT WOS:000386913800017 PM 27285288 ER PT J AU Crooks, JL Cascio, WE Percy, MS Reyes, J Neas, LM Hilborn, ED AF Crooks, James Lewis Cascio, Wayne E. Percy, Madelyn S. Reyes, Jeanette Neas, Lucas M. Hilborn, Elizabeth D. TI The Association between Dust Storms and Daily Non-Accidental Mortality in the United States, 1993-2005 SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article ID CASE-CROSSOVER DESIGN; DESERT DUST; PARTICULATE MATTER; SAHARAN DUST; HOSPITAL ADMISSIONS; AIR-POLLUTION; EVENTS; TAIWAN; OUTBREAKS; TAIPEI AB BACKGROUND: The impact of dust storms on human health has been studied in the context of Asian, Saharan, Arabian, and Australian storms, but there has been no recent population-level epidemiological research on the dust storms in North America. The relevance of dust storms to public health is likely to increase as extreme weather events are predicted to become more frequent with anticipated changes in climate through the 21st century. OBJECTIVES: We examined the association between dust storms and county-level non-accidental mortality in the United States from 1993 through 2005. METHODS: Dust storm incidence data, including date and approximate location, are taken from the U.S. National Weather Service storm database. County-level mortality data for the years 1993-2005 were acquired from the National Center for Health Statistics. Distributed lag conditional logistic regression models under a time-stratified case-crossover design were used to study the relationship between dust storms and daily mortality counts over the whole United States and in Arizona and California specifically. End points included total non-accidental mortality and three mortality subgroups (cardiovascular, respiratory, and other non-accidental). RESULTS: We estimated that for the United States as a whole, total non-accidental mortality increased by 7.4% (95% CI: 1.6, 13.5; p=0.011) and 6.7% (95% CI: 1.1, 12.6; p=0.018) at 2- and 3-day lags, respectively, and by an average of 2.7% (95% CI: 0.4, 5.1; p=0.023) over lags 0-5 compared with referent days. Significant associations with non-accidental mortality were estimated for California (lag 2 and 0-5 day) and Arizona (lag 3), for cardiovascular mortality in the United States (lag 2) and Arizona (lag 3), and for other non-accidental mortality in California (lags 1-3 and 0-5). CONCLUSIONS: Dust storms are associated with increases in lagged non-accidental and cardiovascular mortality. C1 [Crooks, James Lewis; Cascio, Wayne E.; Neas, Lucas M.; Hilborn, Elizabeth D.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC USA. [Crooks, James Lewis] Natl Jewish Hlth, Div Biostat & Bioinformat, 1400 Jackson St, Denver, CO 80206 USA. [Percy, Madelyn S.] Univ N Carolina, Dept Geol, CB 3315, Chapel Hill, NC 27599 USA. [Reyes, Jeanette] Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC USA. RP Crooks, JL (reprint author), Natl Jewish Hlth, Div Biostat & Bioinformat, 1400 Jackson St, Denver, CO 80206 USA. EM CrooksJ@njhealth.org NR 43 TC 0 Z9 0 U1 5 U2 5 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD NOV PY 2016 VL 124 IS 11 BP 1735 EP 1743 DI 10.1289/EHP216 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA EA8UF UT WOS:000386913800018 PM 27128449 ER PT J AU Silva, RA Adelman, Z Fry, MM West, JJ AF Silva, Raquel A. Adelman, Zachariah Fry, Meridith M. West, J. Jason TI The Impact of Individual Anthropogenic Emissions Sectors on the Global Burden of Human Mortality due to Ambient Air Pollution SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article ID INTERCOMPARISON PROJECT ACCMIP; PARTICULATE MATTER EXPOSURE; SOURCE APPORTIONMENT; PREMATURE MORTALITY; ATMOSPHERIC CHEMISTRY; SENSITIVITY-ANALYSIS; OZONE EXPOSURE; MODEL; DISEASE; QUALITY AB BACKGROUND: Exposure to ozone and fine particulate matter (PM2.5) can cause adverse health effects, including premature mortality due to cardiopulmonary diseases and lung cancer. Recent studies quantify global air pollution mortality but not the contribution of different emissions sectors, or they focus on a specific sector. OBJECTIVES: We estimated the global mortality burden of anthropogenic ozone and PM2.5, and the impact of five emissions sectors, using a global chemical transport model at a finer horizontal-resolution (0.67 degrees x 0.5 degrees) than previous studies. METHODS: We performed simulations for 2005 using the Model for Ozone and Related Chemical Tracers, version 4 (MOZART-4), zeroing out all anthropogenic emissions and emissions from specific sectors (All Transportation, Land Transportation, Energy, Industry, and Residential and Commercial). We estimated premature mortality using a log-linear concentration-response function for ozone and an integrated exposure-response model for PM2.5. RESULTS: We estimated 2.23 (95% CI: 1.04, 3.33) million deaths/year related to anthropogenic PM2.5, with the highest mortality in East Asia (48%). The Residential and Commercial sector had the greatest impact globally-675 (95% CI: 428, 899) thousand deaths/year-and in most regions. Land Transportation dominated in North America (32% of total anthropogenic PM2.5 mortality), and it had nearly the same impact (24%) as Residential and Commercial (27%) in Europe. Anthropogenic ozone was associated with 493 (95% CI: 122, 989) thousand deaths/year, with the Land Transportation sector having the greatest impact globally (16%). CONCLUSIONS: The contributions of emissions sectors to ambient air pollution-related mortality differ among regions, suggesting region-specific air pollution control strategies. Global sector-specific actions targeting Land Transportation (ozone) and Residential and Commercial (PM2.5) sectors would particularly benefit human health. C1 [Silva, Raquel A.; Adelman, Zachariah; Fry, Meridith M.; West, J. Jason] Univ North Carolina Chapel Hill, Dept Environm Sci & Engn, Chapel Hill, NC USA. [Fry, Meridith M.] US EPA, Appl Sci & Educ Div, Off Res & Dev, Washington, DC 20460 USA. RP West, JJ (reprint author), Univ North Carolina Chapel Hill, 146B Rosenau Hall CB 7431, Chapel Hill, NC 27599 USA. EM jjwest@email.unc.edu RI West, Jason/J-2322-2015 OI West, Jason/0000-0001-5652-4987 FU Portuguese Foundation for Science and Technology; UNC Graduate School Dissertation Completion Fellowship; National Institutes of Health/National Institute of Environmental Health Sciences [1 R21 ES022600-01]; ICCT FX We acknowledge funding from a fellowship from the Portuguese Foundation for Science and Technology (R.A.S.), a UNC Graduate School Dissertation Completion Fellowship (R.A.S.), National Institutes of Health/National Institute of Environmental Health Sciences grant no. 1 R21 ES022600-01 (J.J.W.), and the ICCT (J.J.W.). NR 50 TC 1 Z9 1 U1 19 U2 19 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD NOV PY 2016 VL 124 IS 11 BP 1776 EP 1784 DI 10.1289/EHP177 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA EA8UF UT WOS:000386913800023 PM 27177206 ER PT J AU LaKind, JS Overpeck, J Breysse, PN Backer, L Richardson, SD Sobus, J Sapkota, A Upperman, CR Jiang, CS Ben Beard, C Brunkard, JM Bell, JE Harris, R Chretien, JP Peltier, RE Chew, GL Blount, BC AF LaKind, Judy S. Overpeck, Jonathan Breysse, Patrick N. Backer, Lorrie Richardson, Susan D. Sobus, Jon Sapkota, Amir Upperman, Crystal R. Jiang, Chengsheng Ben Beard, C. Brunkard, J. M. Bell, Jesse E. Harris, Ryan Chretien, Jean-Paul Peltier, Richard E. Chew, Ginger L. Blount, Benjamin C. TI Exposure science in an age of rapidly changing climate: challenges and opportunities SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY LA English DT Review DE climate change; exposure science; extreme events; indoor environments; non-targeted analysis; sensors ID DISINFECTION BY-PRODUCTS; SALINE WASTE-WATER; CANADIAN FOREST-FIRES; WEST NILE VIRUS; DRINKING-WATER; UNITED-STATES; MASS-SPECTROMETRY; AIR-POLLUTION; EPIDEMIOLOGIC EVIDENCE; EMERGING CONTAMINANTS AB Climate change is anticipated to alter the production, use, release, and fate of environmental chemicals, likely leading to increased uncertainty in exposure and human health risk predictions. Exposure science provides a key connection between changes in climate and associated health outcomes. The theme of the 2015 Annual Meeting of the International Society of Exposure Science Exposures in an Evolving Environment-brought this issue to the fore. By directing attention to questions that may affect society in profound ways, exposure scientists have an opportunity to conduct "consequential science"-doing science that matters, using our tools for the greater good and to answer key policy questions, and identifying causes leading to implementation of solutions. Understanding the implications of changing exposures on public health may be one of the most consequential areas of study in which exposure scientists could currently be engaged. In this paper, we use a series of case studies to identify exposure data gaps and research paths that will enable us to capture the information necessary for understanding climate change-related human exposures and consequent health impacts. We hope that paper will focus attention on under-developed areas of exposure science that will likely have broad implications for public health. C1 [LaKind, Judy S.] LaKind Associates LLC, 106 Oakdale Ave, Catonsville, MD 21228 USA. [LaKind, Judy S.] Univ Maryland, Dept Epidemiol & Publ Hlth, Sch Med, Baltimore, MD 21201 USA. [LaKind, Judy S.] Penn State U Coll Med, Hershey Med Ctr, Dept Pediat, Hershey, PA 17033 USA. [Overpeck, Jonathan] Univ Arizona, Inst Environm, ENR2 Bldg,Room N523,1064 East Lowell St, Tucson, AZ 85721 USA. [Breysse, Patrick N.] Natl Ctr Environm Hlth, Agcy Tox Subst & Dis Registry, 4770 Buford Highway NE,MS-F60, Atlanta, GA 30341 USA. [Backer, Lorrie] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, 4770 Buford Highway NE,MS-F60, Atlanta, GA 30341 USA. [Richardson, Susan D.] Univ South Carolina, Dept Chem & Biochem, JM Palms Ctr GSR, 631 Sumter St, Columbia, SC 29208 USA. [Sobus, Jon] US EPA, Natl Exposure Res Lab, Mail Code E205-04, Res Triangle Pk, NC 27711 USA. [Sapkota, Amir; Upperman, Crystal R.; Jiang, Chengsheng] Univ Maryland, Sch Publ Hlth, Maryland Inst Appl Environm Hlth, College Pk, MD 20742 USA. [Ben Beard, C.] Ctr Dis Control & Prevent, Bacterial Dis Branch, Div Vector Borne Dis, Natl Ctr Emerging & Zoonot Infect Dis, Mail Stop P-02,3156 Rampart Rd, Ft Collins, CO 80521 USA. [Brunkard, J. M.] Ctr Dis Control & Prevent, Waterborne Dis Prevent Branch, Mail Stop C-09,1600 Clifton Rd NE, Asheville, NC 28801 USA. [Bell, Jesse E.] North Carolina State Univ, Cooperat Inst Climate & Satellites NC, 151 Patton Ave, Asheville, NC 28801 USA. [Harris, Ryan] USAF, Weather Squadron DOD Appl Climate Serv 14, Asheville, NC USA. [Chretien, Jean-Paul] Def Hlth Agcy, Armed Forces Hlth Surveillance Branch, Silver Spring, MD USA. [Peltier, Richard E.] Univ Massachusetts, Dept Environm Hlth Sci, 149 Goessmann Lab,686 North Pleasant St, Amherst, MA 01003 USA. [Chew, Ginger L.] Ctr Dis Control & Prevent, Air Pollut & Resp Hlth Branch, Div Environm Hazards & Hlth Effects, Natl Ctr Environm Hlth, 4770 Buford Highway NE,MS-F60, Atlanta, GA 30341 USA. [Blount, Benjamin C.] Ctr Dis Control & Prevent, Tobacco & Volatiles Branch, Div Sci Lab, Natl Ctr Environm Hlth, 4770 Buford Highway NE,MS F47, Atlanta, GA 30341 USA. RP LaKind, JS (reprint author), Univ Maryland, Sch Med, LaKind Associates LLC, Dept Epidemiol & Publ Hlth, 106 Oakdale Ave, Catonsville, MD 21228 USA. EM lakindassoc@gmail.com RI Sapkota, Amir/A-5968-2011 FU CDC Foundation FX The findings and conclusions in this report are those of the author(s) and do not necessarily represent the official position of the Centers for Disease Control and Prevention/the Agency for Toxic Substances and Disease Registry, the US Air Force or Navy, or the US Environmental Protection Agency. The United States Environmental Protection Agency through its Office of Research and Development collaborated in the research described here. It has been subjected to Agency administrative review and approved for publication. Dr. LaKind received support from the CDC Foundation and Dr. LaKind consults to both governmental agencies and private clients. NR 112 TC 1 Z9 1 U1 10 U2 10 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1559-0631 EI 1559-064X J9 J EXPO SCI ENV EPID JI J. Expo. Sci. Environ. Epidemiol. PD NOV-DEC PY 2016 VL 26 IS 6 BP 529 EP 538 DI 10.1038/jes.2016.35 PG 10 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA EA3WH UT WOS:000386539500001 PM 27485992 ER PT J AU Nacci, D Proestou, D Champlin, D Martinson, J Waits, ER AF Nacci, Diane Proestou, Dina Champlin, Denise Martinson, John Waits, Eric R. TI Genetic basis for rapidly evolved tolerance in the wild: adaptation to toxic pollutants by an estuarine fish species SO MOLECULAR ECOLOGY LA English DT Article DE adaptation; contemporary evolution; dioxin; evolved tolerance; quantitative trait locus ID ARYL-HYDROCARBON RECEPTOR; KILLIFISH FUNDULUS-HETEROCLITUS; POLYCYCLIC AROMATIC-HYDROCARBONS; MARINE SUPERFUND SITE; ATLANTIC KILLIFISH; DEVELOPMENTAL TOXICITY; POPULATION GENOMICS; NATURAL-POPULATIONS; ZEBRAFISH; EVOLUTION AB Atlantic killifish (Fundulus heteroclitus) residing in some urban and industrialized estuaries of the US eastern seaboard demonstrate recently evolved and extreme tolerance to toxic aryl hydrocarbon pollutants, characterized as dioxin-like compounds (DLCs). Here, we provide an unusually comprehensive accounting (69%) through quantitative trait locus (QTL) analysis of the genetic basis for DLC tolerance in killifish inhabiting an urban estuary contaminated with PCB congeners, the most toxic of which are DLCs. Consistent with mechanistic knowledge of DLC toxicity in fish and other vertebrates, the aryl hydrocarbon receptor (ahr2) region accounts for 17% of trait variation; however, QTL on independent linkage groups and their interactions have even greater explanatory power (44%). QTL interpreted within the context of recently available Fundulus genomic resources and shared synteny among fish species suggest adaptation via interacting components of a complex stress response network. Some QTL were also enriched in other killifish populations characterized as DLC-tolerant and residing in distant urban estuaries contaminated with unique mixtures of pollutants. Together, our results suggest that DLC tolerance in killifish represents an emerging example of parallel contemporary evolution that has been driven by intense human-mediated selection on natural populations. C1 [Nacci, Diane; Proestou, Dina; Champlin, Denise] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA. [Martinson, John; Waits, Eric R.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Ecol Exposure Res Div, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. [Proestou, Dina] Univ Rhode Isl, ARS, USDA,Shellfish Genet, Northeast Area,Natl Cold Water Marine Aquaculture, 469 CBLS,120 Flagg Rd, Kingston, RI 02881 USA. RP Nacci, D (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA. EM Nacci.diane@epa.gov FU National Science Foundation [DEB-1120512] FX This is tracking # ORD-011310 of the US Environmental Protection Agency, Office of Research and Development. This manuscript has been reviewed and approved for publication by the US EPA. An early version of the manuscript benefitted greatly by reviews by Dr. Bryan Clark, Dr. Mark Hahn, Dr. Jeffrey Markert, Dr. Isaac Wirgin, Dr. Caird E. Rexroad III and Mr. Joseph LiVolsi. Technical assistance was provided by Ashley Bertrand and Ian Kirby; graphic design was provided by Patricia DeCastro, SRA, Narragansett, RI. Approval does not signify that the contents necessarily reflect the views and policies of the US EPA. Mention of trade names, products or services does not convey, and should not be interpreted as conveying official US EPA approval, endorsement or recommendation. Data interpretation was aided by reference to a preliminary draft of the F. heteroclitus genome sequence which was supported by funding from the National Science Foundation (DEB-1120512). NR 63 TC 1 Z9 1 U1 17 U2 17 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0962-1083 EI 1365-294X J9 MOL ECOL JI Mol. Ecol. PD NOV PY 2016 VL 25 IS 21 BP 5467 EP 5482 DI 10.1111/mec.13848 PG 16 WC Biochemistry & Molecular Biology; Ecology; Evolutionary Biology SC Biochemistry & Molecular Biology; Environmental Sciences & Ecology; Evolutionary Biology GA EA1LH UT WOS:000386353200015 PM 27662639 ER PT J AU Parry, E Young, TM AF Parry, Emily Young, Thomas M. TI Comparing targeted and non-targeted high-resolution mass spectrometric approaches for assessing advanced oxidation reactor performance SO WATER RESEARCH LA English DT Article DE Non-target analysis; Advanced oxidation; Wastewater; Pharmaceuticals and personal care products; LC-QTOF-MS ID TREATED WASTE-WATER; TRANSFORMATION PRODUCTS; ANTIBIOTIC-RESISTANCE; UV/H2O2 TREATMENT; PHARMACEUTICALS; UV; SUSPECT; SULFAMETHOXAZOLE; MICROPOLLUTANTS; IDENTIFICATION AB High resolution mass spectrometry (HR-MS) offers the opportunity to track large numbers of non-target analytes through water treatment processes, providing a more comprehensive view of reactor performance than targeted evaluation. Both approaches were used to evaluate the performance of a pilot scale advanced oxidation process (AOP) employing ultraviolet light and hydrogen peroxide (UV/H2O2) to treat municipal wastewater effluent. Twelve pharmaceuticals and personal care products were selected as target compounds and added to reactor influent. Target compound removal over a range of flow rates and hydrogen peroxide addition levels was assessed using a liquid chromatograph combined with a quadrupole time-of-flight mass spectrometer (LC-qTOF-MS). Target compound removals were used to determine hydroxyl radical concentrations and UV fluence under pilot scale conditions. The experiments were also analyzed using a nontarget approach, which identified "molecular features" in either reactor influent or effluent. Strong correlation (r = 0.94) was observed between target compound removals calculated using the targeted and non-targeted approaches across the range of reactor conditions tested. The two approaches also produced consistent rankings of the performance of the various reactor operating conditions, although the distribution of compound removal efficiencies was usually less favorable with the broader, nontarget approach. For example, in the UV only treatment 8.3% of target compounds and 2.2% of non-target compounds exhibited removals above 50%, while 100% of target compounds and 74% of non-target compounds exhibited removals above 50% in the best condition tested. These results suggest that HR-MS methods can provide more holistic evaluation of reactor performance, and may reduce biases caused by selection of a limited number of target compounds. HR-MS methods also offer insights into the composition of poorly removed compounds and the formation of transformation products, which were widely detected. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Parry, Emily] Univ Calif Davis, Agr & Environm Chem Grad Grp, One Shields Ave, Davis, CA 95616 USA. [Young, Thomas M.] Univ Calif Davis, Dept Civil & Environm Engn, One Shields Ave, Davis, CA 95616 USA. [Parry, Emily] US EPA, 26 Martin Luther King Dr W, Cincinnati, OH 45220 USA. RP Young, TM (reprint author), Univ Calif Davis, Dept Civil & Environm Engn, One Shields Ave, Davis, CA 95616 USA. EM tyoung@ucdavis.edu OI Young, Thomas/0000-0001-7217-4753 FU National Science Foundation Graduate Research Fellowship [1149997]; Superfund Research Program of the National Institute of Environmental Health Sciences of the National Institutes of Health [P42 ES004699] FX Support for this study was provided by in part by National Science Foundation Graduate Research Fellowship, Grant No. 1149997 and by the Superfund Research Program of the National Institute of Environmental Health Sciences of the National Institutes of Health under Award Number P42 ES004699. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies. We would like to thank Professor Bassam Younis for allowing use of his reactor and Laura Mahoney for her reactor operating expertise and assistance in sampling. Daniel Cutherburtson (Agilent) provided invaluable assistance with Mass Profiler Professional. Jenny Mital supplied valuable statistical help. NR 32 TC 0 Z9 0 U1 8 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0043-1354 J9 WATER RES JI Water Res. PD NOV 1 PY 2016 VL 104 BP 72 EP 81 DI 10.1016/j.watres.2016.07.056 PG 10 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA EA2DB UT WOS:000386401900008 PM 27518144 ER PT J AU Abokifa, AA Yang, YJ Lo, CS Biswas, P AF Abokifa, Ahmed A. Yang, Y. Jeffrey Lo, Cynthia S. Biswas, Pratim TI Investigating the role of biofilms in trihalomethane formation in water distribution systems with a multicomponent model SO WATER RESEARCH LA English DT Article DE Chlorine; Biofilm; Disinfection by-products; Biomass-derived precursor; Multi species; Reactive transport ID DISINFECTION BY-PRODUCTS; EXTRACELLULAR POLYMERIC SUBSTANCES; DRINKING-WATER; HETEROTROPHIC BACTERIA; DISTRIBUTION NETWORKS; FORMATION KINETICS; 2ND-ORDER MODEL; DBP FORMATION; CHLORINE; TRANSPORT AB Biofilms are ubiquitous in the pipes of drinking water distribution systems (DWDSs), and recent experimental studies revealed that the chlorination of the microbial carbon associated with the biofilm contributes to the total disinfection by-products (DBPs) formation with distinct mechanisms from those formed from precursors derived from natural organic matter (NOM). A multiple species reactive transport model was developed to explain the role of biofilms in DBPs formation by accounting for the simultaneous transport and interactions of disinfectants, organic compounds, and biomass. Using parameter values from experimental studies in the literature, the model equations were solved to predict chlorine decay and microbial regrowth dynamics in an actual DWDS, and trihalomethanes (THMs) formation in a pilot-scale distribution system simulator. The model's capability of reproducing the measured concentrations of free chlorine, suspended biomass, and THMs under different hydrodynamic and temperature conditions was demonstrated. The contribution of bacteria-derived precursors to the total THMs production was found to have a significant dependence on the system's hydraulics, seasonal variables, and the quality of the treated drinking water. Under system conditions that promoted fast bacterial re-growth, the transformation of non-microbial into microbial carbon DBP precursors by the biofilms showed a noticeable effect on the kinetics of THMs formation, especially when a high initial chlorine dose was applied. These conditions included elevated water temperature and high concentrations of nutrients in the influent water. The fraction of THMs formed from microbial sources was found to reach a peak of 12% of the total produced THMs under the investigated scenarios. The results demonstrated the importance of integrating bacterial regrowth dynamics in predictive DBPs formation models. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Abokifa, Ahmed A.; Lo, Cynthia S.; Biswas, Pratim] Washington Univ, Dept Energy Environm & Chem Engn, St Louis, MO 63130 USA. [Yang, Y. Jeffrey] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Biswas, P (reprint author), Washington Univ, Dept Energy Environm & Chem Engn, St Louis, MO 63130 USA. EM ahmed.abokifa@wustl.edu; yang.jeff@epa.gov; clo@wustl.edu; pbiswas@wustl.edu FU U.S. EPA [EP-C-4-014] FX This work was partially funded by U.S. EPA through the CBI Contract EP-C-4-014. The research described herein has been subjected to the Agency's peer and administrative review and has been approved for external publication. Any opinions expressed in this paper are those of the authors and do not necessarily reflect the views of the Agency, therefore, no official endorsement should be inferred. Any mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 47 TC 0 Z9 0 U1 24 U2 24 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0043-1354 J9 WATER RES JI Water Res. PD NOV 1 PY 2016 VL 104 BP 208 EP 219 DI 10.1016/j.watres.2016.08.006 PG 12 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA EA2DB UT WOS:000386401900022 PM 27525584 ER PT J AU Crone, BC Garland, JL Sorial, GA Vane, LM AF Crone, Brian C. Garland, Jay L. Sorial, George A. Vane, Leland M. TI Significance of dissolved methane in effluents of anaerobically treated low strength wastewater and potential for recovery as an energy product: A review SO WATER RESEARCH LA English DT Review DE Anaerobic treatment; Bioreactor; Dissolved methane; Degassing; Membrane ID MEMBRANE BIOREACTOR TREATMENT; HOLLOW-FIBER MEMBRANES; HANGING SPONGE REACTOR; RAW DOMESTIC SEWAGE; DEGASSING MEMBRANE; UASB REACTOR; BIOLOGICAL OXIDATION; GREENHOUSE-GAS; PILOT-SCALE; SAF-MBR AB The need for energy efficient Domestic Wastewater (DWW) treatment is increasing annually with population growth and expanding global energy demand. Anaerobic treatment of low strength DWW produces methane which can be used to as an energy product. Temperature sensitivity, low removal efficiencies (Chemical Oxygen Demand (COD), Suspended Solids (SS), and Nutrients), alkalinity demand, and potential greenhouse gas (GHG) emissions have limited its application to warmer climates. Although well designed anaerobic Membrane Bioreactors (AnMBRs) are able to effectively treat DWW at psychrophilic temperatures (10-30 degrees C), lower temperatures increase methane solubility leading to increased energy losses in the form of dissolved methane in the effluent. Estimates of dissolved methane losses are typically based on concentrations calculated using Henry's Law but advection limitations can lead to supersaturation of methane between 1.34 and 6.9 times equilibrium concentrations and 11-100% of generated methane being lost in the effluent. In well mixed systems such as AnMBRs which use biogas sparging to control membrane fouling, actual concentrations approach equilibrium values. Non-porous membranes have been used to recover up to 92.6% of dissolved methane and well suited for degassing effluents of Upflow Anaerobic Sludge Blanket (UASB) reactors which have considerable solids and organic contents and can cause pore wetting and clogging in microporous membrane modules. Micro porous membranes can recover up to 98.9% of dissolved methane in AnMBR effluents which have low COD and SS concentrations. Sequential Down-flow Hanging Sponge (DHS) reactors have been used to recover between 57 and 88% of dissolved methane from Upflow Anaerobic Sludge Blanket (UASB) reactor effluent at concentrations of greater than 30% and oxidize the rest for a 99% removal of total dissolved methane. They can also remove 90% of suspended solids and COD in UASB effluents and produce a high quality effluent. In situ degassing, can increase process stability, COD removal, biomass retention, and headspace methane concentrations. A model for estimating energy consumption associated with membrane-based dissolved methane recovery predicts that recovered dissolved and headspace methane may provide all the energy required for operation of an anaerobic system treating DWW at psychrophilic temperatures. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Crone, Brian C.; Garland, Jay L.] US EPA, Natl Exposure Res Lab, Off Res & Dev, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA. [Crone, Brian C.; Sorial, George A.] Univ Cincinnati, Dept Biomed Chem & Environm Engn, POB 210012, Cincinnati, OH 45220 USA. [Vane, Leland M.] US Environm Protect Agcy Lab, Natl Risk Management Res Lab, Off Res & Dev, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA. RP Crone, BC (reprint author), Univ Cincinnati, Dept Biomed Chem & Environm Engn, POB 210012, Cincinnati, OH 45220 USA. EM Crone.Brian@epa.gov; Garland.Jay@epa.gov; sorialga@ucmail.uc.edu; Vane.Leland@epa.gov FU United States Environmental Protection Agency through its Office of Research and Development FX The United States Environmental Protection Agency through its Office of Research and Development funded and managed the research described here. It has been subjected to Agency's administrative review and approved for publication. The contribution of Brian C. Crone was administered through a student services contract. The views expressed in this article are those of the author(s) and do not necessarily represent the views or policies of the U.S. Environmental Protection Agency. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 87 TC 1 Z9 1 U1 41 U2 41 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0043-1354 J9 WATER RES JI Water Res. PD NOV 1 PY 2016 VL 104 BP 520 EP 531 DI 10.1016/j.watres.2016.08.019 PG 12 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA EA2DB UT WOS:000386401900053 PM 27595700 ER PT J AU Sun, Y Tong, S Yang, YJ AF Sun, Yu Tong, Susanna Yang, Y. Jeffrey TI Modeling the cost-effectiveness of stormwater best management practices in an urban watershed in Las Vegas Valley SO APPLIED GEOGRAPHY LA English DT Article DE Stormwater BMPs; SUSTAIN; GIS modeling; Watershed management; Urbanization; Climate change ID LAND-USE; NEVADA; IMPACT; CONSERVATION; DYNAMICS; SYSTEM AB The Las Vegas Valley is one of the fastest growing urban areas in the United States. Any future urbanization and climate change, especially if the climate becomes wetter and there are more intense and frequent storm events, will undoubtedly cause excessive urban stormwater runoff and exacerbate flooding in the Valley. Stormwater management is therefore one of the key challenges to the local government. The main goal of this study was to ascertain the utility of Best management Practices (BMPs) in mitigating stormwater runoff in the Duck Creek watershed in the Las Vegas Valley. The cost-effectiveness of different BMPs were also compared so as to determine the best BMP arrangement under the current and future climate and land use change conditions. By applying SUSTAIN (System for Urban Stormwater Treatment and Analysis INtegration) as a comprehensive GIS-based modeling and decision support system in the BMP analyses, modeling results show that although the installation of the existing three detention basins in the watershed can provide a 9% flow reduction, these three detention basins alone will not be adequate in the future with the impending changes in climate and land use. To alleviate the potential problems of water resources, SUSTAIN was further used to determine the number of additional BMPs required, the optimal types of BMPs (such as, detention and infiltration BMPs), and their locations in reducing storm runoff in the watershed under the future land-use and climate regimes. By comparing the performances of five potential BMP implementation scenarios, it was found that a mixed implementation of one additional detention BMP and one infiltration BMP to the existing detention BMPs in the downstream area of the watershed would be the most cost-effective stormwater runoff control solution in face of future urbanization and climate change. Depending on the locations of the new detention and infiltration BMPs, surface flow, even without BMP retrofit options, could be reduced by 27 -31%. The cost for such installations would range from $1,141,000 to $1,319,000. This information may be useful to local planners and water resource managers in their efforts to develop alternative stormwater management plans in the arid Southwest. (C) 2016 Elsevier Ltd. All rights C1 [Sun, Yu] Univ North Georgia, Inst Environm & Spatial Anal, Oakwood, GA 30566 USA. [Tong, Susanna] Univ Cincinnati, Dept Geog, Cincinnati, OH 45221 USA. [Yang, Y. Jeffrey] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Sun, Y (reprint author), Univ North Georgia, Inst Environm & Spatial Anal, Oakwood, GA 30566 USA. EM yu.sun@ung.edu FU U.S. Environmental Protection Agency, through its Office of Research and Development FX The U.S. Environmental Protection Agency, through its Office of Research and Development, partially funded and collaborated in, the research described herein. The authors are grateful to the agency for their financial support. NR 41 TC 0 Z9 0 U1 16 U2 16 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0143-6228 EI 1873-7730 J9 APPL GEOGR JI Appl. Geogr. PD NOV PY 2016 VL 76 BP 49 EP 61 DI 10.1016/j.apgeog.2016.09.005 PG 13 WC Geography SC Geography GA DZ9IK UT WOS:000386188300005 ER PT J AU Pleil, JD AF Pleil, Joachim D. TI Breath biomarkers in toxicology SO ARCHIVES OF TOXICOLOGY LA English DT Review DE Human exposome; Exhaled breath; Breath condensate; Cellular respiration; Mass spectrometry; Adverse outcome pathway ID VOLATILE ORGANIC-COMPOUNDS; REACTION-MASS-SPECTROMETRY; THROUGHPUT SCREENING ASSAYS; TRACE GAS-ANALYSIS; ION FLOW TUBE; EXHALED BREATH; IN-VITRO; ENVIRONMENTAL CHEMICALS; HELICOBACTER-PYLORI; LUNG-CANCER AB Exhaled breath has joined blood and urine as a valuable resource for sampling and analyzing biomarkers in human media for assessing exposure, uptake metabolism, and elimination of toxic chemicals. This article focuses current use of exhaled gas, aerosols, and vapor in human breath, the methods for collection, and ultimately the use of the resulting data. Some advantages of breath are the noninvasive and self-administered nature of collection, the essentially inexhaustible supply, and that breath sampling does not produce potentially infectious waste such as needles, wipes, bandages, and glassware. In contrast to blood and urine, breath samples can be collected on demand in rapid succession and so allow toxicokinetic observations of uptake and elimination in any time frame. Furthermore, new technologies now allow capturing condensed breath vapor directly, or just the aerosol fraction alone, to gain access to inorganic species, lung pH, proteins and protein fragments, cellular DNA, and whole microorganisms from the pulmonary microbiome. Future applications are discussed, especially the use of isotopically labeled probes, non-targeted (discovery) analysis, cellular level toxicity testing, and ultimately assessing "crowd breath" of groups of people and the relation to dose of airborne and other environmental chemicals at the population level. C1 [Pleil, Joachim D.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA. RP Pleil, JD (reprint author), US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA. EM pleil.joachim@epa.gov NR 171 TC 1 Z9 1 U1 22 U2 22 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0340-5761 EI 1432-0738 J9 ARCH TOXICOL JI Arch. Toxicol. PD NOV PY 2016 VL 90 IS 11 BP 2669 EP 2682 DI 10.1007/s00204-016-1817-5 PG 14 WC Toxicology SC Toxicology GA EA1VR UT WOS:000386380700007 PM 27585664 ER PT J AU Cahill, TA Barnes, DE Lawton, JA Miller, R Spada, N Willis, RD Kimbrough, S AF Cahill, Thomas A. Barnes, David E. Lawton, Jonathan A. Miller, Roger Spada, Nicholas Willis, Robert D. Kimbrough, Sue TI Transition metals in coarse, fine, very fine and ultra-fine particles from an interstate highway transect near Detroit SO ATMOSPHERIC ENVIRONMENT LA English DT Article DE Aerosols; Highway; Size profiles; Lateral transects; Ultra fine metals ID SOUTHERN CALIFORNIA COMMUNITIES; AIR PARTICULATE MATTER; DIFFERING LEVELS; MAJOR HIGHWAY; LUNG-FUNCTION; POLLUTION; ROAD; DOWNWIND; CHILDREN; DIESEL AB As one component of a study investigating the impact of vehicle emissions on near-road air quality, human exposures, and potential health effects, particles were measured from September 21 to October 30, 2010 on both sides of a major roadway (Interstate-96) in Detroit. Traffic moved freely on this 12 lane freeway with a mean velocity of 69 mi/hr. with little braking and acceleration. The UC Davis DELTA Group rotating drum (DRUM) impactors were used to collect particles in 8 size ranges at sites nominally 100 m south, 10 m north, 100 m north, and 300 m north of the highway. Ultra-fine particles were continuously collected at the 10 m north and 100 m north sites. Samples were analyzed every 3 h for mass (soft beta ray transmission), 42 elements (synchrotron-induced x-ray fluorescence) and optical attenuation (350 -800 nm spectroscopy). A three day period of steady southerly winds along the array allowed direct measurement of freeway emission rates for coarse (10 > D-p > 1.0 mu m), PM2.5, very fine (0.26 > D-p > 0.09 mu m), and ultra-fine (D-p < 0.09 mu m) particles. The PM2.5 mass concentrations were modeled using literature emission rates during the south to north wind periods, and averaged 1.6 +/- 0.5 mu g/m(3), versus the measured value of 2.0 +/- 0.7 mu g/m(3). Using European freeway emission rates from 2010, and modeling them at the I-96 site, we would predict roughly 3.1 mu g/m(3) of PM2.5 particles, corrected from the 4.9 PM10 value by their measured road dust contributions. Using California car and truck emission rates of 1973, this value would have been about 16 mu g/m(3), corrected down from the 19 mu g/m(3) PM5.0 using measured roadway dust contributions. This would have included 2.7 mu g/m(3) of lead, versus the 0.0033 mu g/m(3) measured. Very fine particles were distributed across the array with a relatively weak falloff versus distance. For the ultra-fine particles, emissions of soot and metals seen in vehicular braking studies correlated with traffic at the 10 m site, but only the soot was statistically significant at the 100 m north site. Otherwise, the 10 m north and 100 m north sites were essentially identical in mean concentration and highly correlated in time for most of the 5 week study. This result supports earlier publications showing the ability of very fine and ultra-fine particles to transport to sites well removed from the freeway sources. The concentrations of very fine and ultra-fine metals from brake wear and zinc in motor oil observed in Detroit have the potential of being a significant component in statistically established PM2.5 mortality rates. (C) 2016 The Authors. Published by Elsevier Ltd. C1 [Cahill, Thomas A.; Barnes, David E.; Lawton, Jonathan A.; Miller, Roger] Univ Calif Davis, DELTA Grp, Davis, CA 95616 USA. [Spada, Nicholas] Univ Houston, Houston, TX USA. [Willis, Robert D.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Kimbrough, Sue] US EPA, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. RP Cahill, TA (reprint author), Univ Calif Davis, DELTA Grp, Davis, CA 95616 USA. EM tomandginny12@gmail.com OI Kimbrough, Evelyn Sue/0000-0002-7246-0255 FU United States Environmental Protection Agency through its Office of Research and Development [EP-12-D-000219] FX The authors gratefully acknowledge the assistance in meteorological models of Ron Henry, as well as the detailed aethalometer, meteorological and traffic data of the US EPA/FHWA study (US EPA, 2013). The United States Environmental Protection Agency through its Office of Research and Development funded and collaborated in the research described here under contract EP-12-D-000219 to the University of California, Davis. It has been subjected to Agency review and approved for publication. NR 34 TC 1 Z9 1 U1 12 U2 12 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 EI 1873-2844 J9 ATMOS ENVIRON JI Atmos. Environ. PD NOV PY 2016 VL 145 BP 158 EP 175 DI 10.1016/j.atmosenv.2016.09.023 PG 18 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA EA2JI UT WOS:000386418200016 ER PT J AU Oakes, MM Burke, JM Norris, GA Kovalcik, KD Pancras, JP Landis, MS AF Oakes, Michelle M. Burke, Janet M. Norris, Gary A. Kovalcik, Kasey D. Pancras, J. Patrick Landis, Matthew S. TI Near-road enhancement and solubility of fine and coarse particulate matter trace elements near a major interstate in Detroit, Michigan SO ATMOSPHERIC ENVIRONMENT LA English DT Article DE Air pollution; PM; Trace metals; Traffic sources; Brake wear ID IRON SOLUBILITY; SOURCE APPORTIONMENT; OXIDATIVE STRESS; PARTICLES; URBAN; EMISSIONS; WEAR; MECHANISMS; POLLUTANTS; SPECIATION AB Communities near major roadways are disproportionately affected by traffic-related air pollution which can contribute to adverse health outcomes. The specific role of particulate matter (PM) from traffic sources is not fully understood due to complex emissions processes and physical/chemical properties of PM in the near-road environment. To investigate the spatial profile and water solubility of elemental PM species near a major roadway, filter-based measurements of fine (PM2.5) and coarse (PM10-2.5) PM were simultaneously collected at multiple distances (10 m, 100 m, and 300 m) from Interstate I-96 in Detroit, Michigan during September November 2010. Filters were extracted in water, followed by a hot acid extraction, and analyzed by magnetic sector field high resolution inductively coupled plasma mass spectrometry (HR-ICPMS) to quantify water-soluble and acid-soluble trace elements for each PM size fraction. PM2.5 and PM10-2.5 species measured in the near-road samples included elements associated with traffic activity, local industrial sources, and regional pollution. Metals indicative of brake wear (Ba, Cu) were dramatically enriched near the roadway during downwind conditions (factor of 5 concentration increase), with the largest increase within 100 m of the roadway. Moderate near-roadway increases were observed for crustal elements and other traffic-related PM (Fe, Ca), and the lowest increases observed for regional PM species (S). Water solubility varied by PM species and size, and for PM2.5 included highly (S, K, Ca, Mg, Zn, Ba), moderately (Cu, Mn, Sb, Pb), and minimally (Fe, Ti) water-soluble species, with lower water solubility for most species in PM10-2.5. Results from this study indicate that water-soluble PM2.5 and PM10-2.5 metals, particularly from brake/tire wear, were enhanced in the near-roadway environment which may have human health implications. Published by Elsevier Ltd. C1 [Oakes, Michelle M.] US EPA, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA. [Burke, Janet M.; Norris, Gary A.; Kovalcik, Kasey D.; Landis, Matthew S.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Pancras, J. Patrick] Alion Sci & Technol, Res Triangle Pk, NC USA. [Oakes, Michelle M.] Tennessee Dept Environm & Conservat, Div Air Pollut Control, Nashville, TN USA. RP Burke, JM (reprint author), US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. EM burke.janet@epa.gov FU U.S. Environmental Protection Agency (EPA) through its Office of Research and Development [EP-D-10-070] FX The U.S. Environmental Protection Agency (EPA) through its Office of Research and Development conducted the research described here, partially funded under contract EP-D-10-070 (Alion Science and Technology). It has been subjected to Agency review and approved for publication. Mention of trade names or commercial products do not constitute an endorsement or recommendation for use. We thank Sue Kimbrough (EPA) and collaborators on the EPA/FHWA study for providing the meteorological data at each site; Alan Vette, Sarah Bereznicki, and Ali Kamal (EPA) for conducting the PM field sampling during the NEXUS study; Michael Wheeler and Keith Kronmiller (Alion) for onsite logistical support; Brad Edgerton (ARA) for filter preparation and weighing; Teri Conner (EPA) for preparing and thoroughly reviewing the sampler and filter data; and Carry Croghan (EPA) for preparing final datasets. NR 42 TC 3 Z9 3 U1 20 U2 20 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 EI 1873-2844 J9 ATMOS ENVIRON JI Atmos. Environ. PD NOV PY 2016 VL 145 BP 213 EP 224 DI 10.1016/j.atmosenv.2016.09.034 PG 12 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA EA2JI UT WOS:000386418200020 ER PT J AU Bost, PC Strynar, MJ Reiner, JL Zweigenbaum, JA Secoura, PL Lindstrom, AB Dye, JA AF Bost, Phillip C. Strynar, Mark J. Reiner, Jessica L. Zweigenbaum, Jerry A. Secoura, Patricia L. Lindstrom, Andrew B. Dye, Janice A. TI US domestic cats as sentinels for perfluoroalkyl substances: Possible linkages with housing, obesity, and disease SO ENVIRONMENTAL RESEARCH LA English DT Article DE Cats; Obesity; Perfluoroalkyl substances (PFAS); Sentinels ID ENVIRONMENTAL TOBACCO-SMOKE; SULFONATE PFOS EXPOSURE; PERFLUOROOCTANE SULFONATE; PERFLUORINATED COMPOUNDS; SERUM CONCENTRATIONS; COMPARATIVE PHARMACOKINETICS; LIVER-FUNCTION; ANIMAL-MODEL; ONE HEALTH; PET CATS AB Perfluoroalkyl substances (PFAS), such as perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), are persistent, globally distributed, anthropogenic compounds. The primary source(s) for human exposure are not well understood although within home exposure is likely important since many consumer products have been treated with different PFAS, and people spend much of their lives indoors. Herein, domestic cats were used as sentinels to investigate potential exposure and health linkages. PFAS in serum samples of 72 pet and feral cats, including 11 healthy and 61 with one or more primary disease diagnoses, were quantitated using high-resolution time-of-flight mass spectroscopy. All but one sample had detectable PFAS, with PFOS and perfluorohexane sulfonate (PFHxS) ranging from < LOQ to 121 and < LOQ to 235 ng/mL, respectively. PFAS prevalence and geometric means in cats were very similar to contemporary NHANES reports of human sera in the U. S. population. The highest PFAS serum concentrations detected were in indoor cats due to disproportionately elevated PFHxS levels. Ranked by quartile, contingency testing indicated that total PFAS levels were positively associated with living indoors and with higher body weight and body condition scores. Individual PFAS quartile rankings suggested positive associations with respiratory effusion, thyroid, liver, and possibly chronic kidney disease. Domestic cats appear to be useful sentinels for assessing primary PFAS exposure routes, especially indoor sources of relevance to children. Additional case-control studies in pet cats are warranted to better define the potential health associations observed herein. A "One Health" approach assessing humans, pets, and their common environment may improve our understanding of chronic, low-level, largely indoor, PFAS exposure and effects in humans and animals alike. Published by Elsevier Inc. C1 [Bost, Phillip C.] US EPA, Res Triangle Pk, NC 27711 USA. [Strynar, Mark J.; Lindstrom, Andrew B.] US EPA, Natl Exposure Res Lab, Exposure Methods & Measurement Div, Res Triangle Pk, NC 27711 USA. [Reiner, Jessica L.] NIST, Hollings Marine Lab, Charleston, SC 29412 USA. [Zweigenbaum, Jerry A.] Agilent Technol, Wilmington, DE 19808 USA. [Secoura, Patricia L.] North Carolina State Univ, Vet Teaching Hosp, Raleigh, NC 27606 USA. [Dye, Janice A.] US EPA, Natl Hlth & Environm Effects Res Lab, Environm Publ Hlth Div, Res Triangle Pk, NC 27711 USA. RP Dye, JA (reprint author), US EPA, ORD NHEERL EPHD, Mail Drop B-105-02, Res Triangle Pk, NC 27711 USA. EM dye.janice@epa.gov FU [EP10D000071] FX This work was conducted with assistance from Cooperative Research and Development Agreements (CRADA) with Agilent Technologies (#437-07). It was partially supported under Student Service Contract # EP10D000071. NR 69 TC 0 Z9 0 U1 14 U2 14 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0013-9351 EI 1096-0953 J9 ENVIRON RES JI Environ. Res. PD NOV PY 2016 VL 151 BP 145 EP 153 DI 10.1016/j.envres.2016.07.027 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA EA2HO UT WOS:000386413600017 PM 27479711 ER PT J AU Hampel, R Breitner, S Kraus, WE Hauser, E Shah, S Ward-Caviness, CK Devlin, R Diaz-Sanchez, D Neas, L Cascio, W Peters, A Schneider, A AF Hampel, Regina Breitner, Susanne Kraus, William E. Hauser, Elizabeth Shah, Svati Ward-Caviness, Cavin K. Devlin, Robert Diaz-Sanchez, David Neas, Lucas Cascio, Wayne Peters, Annette Schneider, Alexandra TI Short-term effects of air temperature on plasma metabolite concentrations in patients undergoing cardiac catheterization SO ENVIRONMENTAL RESEARCH LA English DT Article DE Air temperature; Metabolites; Cardiovascular disease; Epidemiology ID POTENTIALLY SUSCEPTIBLE INDIVIDUALS; CORONARY-ARTERY-DISEASE; 15 EUROPEAN CITIES; CASE-ONLY ANALYSIS; CARDIOVASCULAR EVENTS; HEAT WAVES; BLOOD-PRESSURE; KETONE-BODIES; MORTALITY; IMPACT AB Background: Epidemiological studies have shown associations between air temperature and cardiovascular health outcomes. Metabolic dysregulation might also play a role in the development of cardiovascular disease. Objectives: To investigate short-term temperature effects on metabolites related to cardiovascular disease. Methods: Concentrations of 45 acylcarnitines, 15 amino acids, ketone bodies and total free fatty acids were available in 2869 participants from the CATHeterization GENetics cohort recruited at the Duke University Cardiac Catheterization Clinic (Durham, NC) between 2001 and 2007. Ten metabolites were selected based on quality criteria and cluster analysis. Daily averages of meteorological variables were obtained from the North American Regional Reanalysis project. Immediate, lagged, and cumulative temperature effects on metabolite concentrations were analyzed using (piecewise) linear regression models. Results: Linear temperature effects were found for glycine, C16-OH:C14:1-DC, and aspartic acid/asparagine. A 5 degrees C increase in temperature was associated with a 1.8% [95%-confidence interval: 0.3%; 33%] increase in glycine (5-day average), a 3.2% [0.1%; 6.3%] increase in C16-OH:C14:1-DC (lag of four days), and a -1.4% [-2.4%; -0.3%] decrease in aspartic acid/asparagine (lag of two days). Non-linear temperature effects were observed for alanine and total ketone bodies with breakpoint of 4 degrees C and 20 degrees C, respectively. Both a 5 degrees C decrease in temperature on colder days (<4 degrees C)and a 5 C increase in temperature on warmer days (>= 4 degrees C) were associated with a four day delayed increase in alanine by 6.6% [11.7; 1.8%] and 1.9% [0.3%; 3.4%], respectively. For ketone bodies we found immediate (0-day lag) increases of 4.2% [-0.5%; 9.1%] and 123% [0.1%; 26.0%] associated with 5 degrees C decreases on colder (<20 degrees C) days and 5 degrees C increases on warmer days (>= 20 degrees C), respectively. Conclusions: We observed multiple effects of air temperature on metabolites several of which are reported to be involved in cardiovascular disease. Our findings might help to understand the link between air temperature and cardiovascular disease. (C) 2016 Elsevier Inc. All rights reserved. C1 [Hampel, Regina; Breitner, Susanne; Ward-Caviness, Cavin K.; Peters, Annette; Schneider, Alexandra] German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Munchen, Inst Epidemiol 2, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany. [Kraus, William E.; Hauser, Elizabeth; Shah, Svati] Duke Univ, Sch Med, Durham, NC 27701 USA. [Hauser, Elizabeth] Duke Mol Physiol Inst, 300 North Duke St, Durham, NC 27701 USA. [Hauser, Elizabeth] Vet Affairs Med Ctr, Cooperat Studies Program Epidemiol Ctr Durham, Durham, NC 27701 USA. [Devlin, Robert; Diaz-Sanchez, David; Neas, Lucas; Cascio, Wayne] US EPA, Natl Hlth & Environm Effects Res Lab, 109 TW Alexander Dr, Durham, NC 27709 USA. RP Hampel, R (reprint author), German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Munchen, Inst Epidemiol 2, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany. EM regina.hampel@helmholtz-muenchen.de OI Breitner, Susanne/0000-0002-0956-6911; Peters, Annette/0000-0001-6645-0985 FU United States Environmental Protection Agency (EPA) [R-82811201]; Health Effects Institute [4946-RFPA10-3/14-7] FX Research described in this article was conducted under contract to the Health Effects Institute (HEI), and organization jointly funded by the United States Environmental Protection Agency (EPA) (Assistance award no. R-82811201) and certain motor vehicle and engine manufacturers.; This work was partially supported by Health Effects Institute 4946-RFPA10-3/14-7 to WEK. NR 49 TC 0 Z9 0 U1 2 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0013-9351 EI 1096-0953 J9 ENVIRON RES JI Environ. Res. PD NOV PY 2016 VL 151 BP 224 EP 232 DI 10.1016/j.envres.2016.07.010 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA EA2HO UT WOS:000386413600025 PM 27500855 ER PT J AU Karami, A Omar, D Lazorchak, JM Yap, CK Hashim, Z Courtenay, SC AF Karami, Ali Omar, Dzolkhifli Lazorchak, James M. Yap, Chee Kong Hashim, Zailina Courtenay, Simon C. TI A comparison of biomarker responses in juvenile diploid and triploid African catfish, Clarias gariepinus, exposed to the pesticide butachlor SO ENVIRONMENTAL RESEARCH LA English DT Article DE Polyploid; Gene; Biochemical biomarkers; Steroid; Morphometric parameters ID ZEBRAFISH DANIO-RERIO; ENDOCRINE DISRUPTING CHEMICALS; HETEROPNEUSTES-FOSSILIS BLOCH; GONADAL DEVELOPMENT; SURFACE WATERS; FISH; AROMATASE; HORMONE; GROWTH; BRAIN AB Influence of waterborne butachlor (BUC), a commonly used pesticide, on morphometric, biochemical, and molecular biomarkers was evaluated in juvenile, full sibling, diploid and triploid African catfish (Clarias gariepinus). Fish were exposed for 21 days to one of three concentrations of BUC [mean measured mu g/L: 22, 44 or 60]. Unexposed (control) triploids were heavier and longer and had higher visceral somatic index (VSI) than diploids. Also, they had lighter liver weight (HSI) and showed lower transcript levels of brain gonadotropin-releasing hormone (GnRH), aromatase (cyp191b) and fushi tarazu-factor (ftz-f1), and plasma testosterone levels than diploids. Butachlor treatments had no effects, in either diploid or triploid fish, on VSI, HSI, weight or length changes, condition factor (CF), levels of plasma testosterone, 17-beta estradiol (E2), cortisol, cholesterol, or mRNA levels of brain tryptophan hydroxylase (tph2), forkhead box 12 (foxl2), and 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta-hsd2). Expressions of gp191b and ftz-f1 in triploids were upregulated by the two highest concentrations of BUC. In diploid fish, however, exposures to all BUC concentrations decreased GnRH transcription and the medium BUC concentration decreased ftz-f1 transcription. Substantial differences between ploidies in basal biomarker responses are consistent with the reported impaired reproductive axis in triploid C gariepinus. Furthermore, the present study showed the low impact of short term exposure to BUC on reproductive axis in C gariepinus. (C) 2016 Elsevier Inc. All rights reserved. C1 [Karami, Ali; Hashim, Zailina] Univ Putra Malaysia, Fac Med & Hlth Sci, Lab Aquat Toxicol, Serdang 43400, Malaysia. [Omar, Dzolkhifli] Univ Putra Malaysia, Fac Agr, Toxicol Lab, Serdang 43400, Malaysia. [Lazorchak, James M.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. [Yap, Chee Kong] Univ Putra Malaysia, Fac Sci, Dept Biol, Serdang 43400, Malaysia. [Courtenay, Simon C.] Univ Waterloo, Sch Environm Resources & Sustainabil, Canadian Water Network, Canadian Rivers Inst, Waterloo, ON N2L 3G1, Canada. RP Karami, A (reprint author), Univ Putra Malaysia, Fac Med & Hlth Sci, Lab Aquat Toxicol, Serdang 43400, Malaysia. EM alikaramiv@gmail.com OI Lazorchak, James/0000-0002-7354-7571 FU E-Science grant, Ministry of Science, Technology and Innovation (MOSTI), government of Malaysia [01-02-05-SF0017] FX This study was partially funded by E-Science grant (No. 01-02-05-SF0017), Ministry of Science, Technology and Innovation (MOSTI), government of Malaysia. Although this work was subjected to review by the US Environmental Protection Agency and approved for publication, it may not necessarily reflect official Agency policy nor should mention of commercial products be considered endorsement. NR 83 TC 0 Z9 0 U1 4 U2 4 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0013-9351 EI 1096-0953 J9 ENVIRON RES JI Environ. Res. PD NOV PY 2016 VL 151 BP 313 EP 320 DI 10.1016/j.envres.2016.08.006 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA EA2HO UT WOS:000386413600034 PM 27522569 ER PT J AU Weber, SA Insaf, TZ Hall, ES Talbot, TO Huff, AK AF Weber, Stephanie A. Insaf, Tabassum Z. Hall, Eric S. Talbot, Thomas O. Huff, Amy K. TI Assessing the impact of fine particulate matter (PM2.5) on respiratory cardiovascular chronic diseases in the New York City Metropolitan area using Hierarchical Bayesian Model estimates SO ENVIRONMENTAL RESEARCH LA English DT Article DE Aerosol optical depth (AOD); Air quality model; Air Quality System (AQS); Asthma Case crossover; Community Multi-Scale Air Quality (CMAQ) model; Fine particulate matter (PM2.5); Heart failure (HF); Hierarchical Bayesian Model (HBM); Myocardial infarction (MI) ID AEROSOL OPTICAL DEPTH; CASE-CROSSOVER ANALYSIS; REFERENT SELECTION-STRATEGIES; EMERGENCY-DEPARTMENT VISITS; AIR-POLLUTION; TIME-SERIES; MEASUREMENT ERROR; PARTICLES; QUALITY; EPIDEMIOLOGY AB An enhanced research paradigm is presented to address the spatial and temporal gaps in fine particulate matter (PM2.5) measurements and generate realistic and representative concentration fields for use in epidemiological studies of human exposure to ambient air particulate concentrations. The general approach for research designed to analyze health impacts of exposure to PM2.5 is to use concentration data from the nearest ground-based air quality monitor(s), which typically have missing data on the temporal and spatial scales due to filter sampling schedules and monitor placement, respectively. To circumvent these data gaps, this research project uses a Hierarchical Bayesian Model (HBM) to generate estimates of PM2.5 in areas with and without air quality monitors by combining PM2.5 concentrations measured by monitors, PM2.5 concentration estimates derived from satellite aerosol optical depth (AOD) data, and Community-Multiscale Air Quality (CMAQ) model predictions of PM2.5 concentrations. This methodology represents a substantial step forward in the approach for developing representative PM2.5 concentration datasets to correlate with inpatient hospitalizations and emergency room visits data for asthma and inpatient hospitalizations for myocardial infarction (MI) and heart failure (HF) using case-crossover analysis. There were two key objective of this current study. First was to show that the inputs to the HBM could be expanded to include AOD data in addition to data from PM2.5 monitors and predictions from CMAQ. The second objective was to determine if inclusion of AOD surfaces in HBM model algorithms results in PM2.5 air pollutant concentration surfaces which more accurately predict hospital admittance and emergency room visits for MI, asthma, and HF. This study focuses on the New York City, NY metropolitan and surrounding areas during the 2004-2006 time period, in order to compare the health outcome impacts with those from previous studies and focus on any benefits derived from the changes in the HBM model surfaces. Consistent with previous studies, the results show high PM2.5 exposure is associated with increased risk of asthma, myocardial infarction and heart failure. The estimates derived from concentration surfaces that incorporate AOD had a similar model fit and estimate of risk as compared to those derived from combining monitor and CMAQ data alone. Thus, this study demonstrates that estimates of PM2.5 concentrations from satellite data can be used to supplement PM2.5 monitor data in the estimates of risk associated with three common health outcomes. Results from this study were inconclusive regarding the potential benefits derived from adding AOD data to the HBM, as the addition of the satellite data did not significantly increase model performance. However, this study was limited to one metropolitan area over a short two-year time period. The use of next-generation, high temporal and spatial resolution satellite AOD data from geostationary and polar-orbiting satellites is expected to improve predictions in epidemiological studies in areas with fewer pollutant monitors or over wider geographic areas. (C) 2016 The Authors. Published by Elsevier Inc. C1 [Weber, Stephanie A.] Battelle Mem Inst, 505 King Ave, Columbus, OH 43201 USA. [Insaf, Tabassum Z.; Talbot, Thomas O.] New York State Dept Hlth, Albany, NY USA. [Insaf, Tabassum Z.; Talbot, Thomas O.] SUNY Albany, Sch Publ Hlth, Rensselaer, NY USA. [Hall, Eric S.] US EPA, Res Triangle Pk, NC 27711 USA. [Huff, Amy K.] Penn State Univ, University Pk, PA 16802 USA. RP Weber, SA (reprint author), Battelle Mem Inst, 505 King Ave, Columbus, OH 43201 USA. EM WeberS@battelle.org FU NASA [NNH11CD19C] FX This work was funded under NASA grant NNH11CD19C for Earth Science Applications Feasibility Studies: Public Health. The authors would like to thank Michele Morara for his work on updating the HBM and the two anonymous reviewers. NR 41 TC 0 Z9 0 U1 15 U2 15 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0013-9351 EI 1096-0953 J9 ENVIRON RES JI Environ. Res. PD NOV PY 2016 VL 151 BP 399 EP 409 DI 10.1016/j.envres.2016.07.012 PG 11 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA EA2HO UT WOS:000386413600043 PM 27543787 ER PT J AU Lillicrap, A Belanger, S Burden, N Du Pasquier, D Embry, MR Halder, M Lampi, MA Lee, L Norberg-King, T Rattner, BA Schirmer, K Thomas, P AF Lillicrap, Adam Belanger, Scott Burden, Natalie Du Pasquier, David Embry, Michelle R. Halder, Marlies Lampi, Mark A. Lee, Lucy Norberg-King, Teresa Rattner, Barnett A. Schirmer, Kristin Thomas, Paul TI Alternative Approaches to Vertebrate Ecotoxicity Tests in the 21st Century: A Review of Developments Over the Last 2 Decades and Current Status SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Review DE Ecotoxicity; Vertebrate; In vitro; In silico; 3Rs ID EMBRYO TOXICITY TEST; RISK-ASSESSMENT; ORGANIC-CHEMICALS; PLANT-PROTECTION; CELL-CULTURES; FISH; SENSITIVITY; BIRDS; MODEL; BIOACCUMULATION AB The need for alternative approaches to the use of vertebrate animals for hazard assessment of chemicals and pollutants has become of increasing importance. It is now the first consideration when initiating a vertebrate ecotoxicity test, to ensure that unnecessary use of vertebrate organisms is minimized wherever possible. For some regulatory purposes, the use of vertebrate organisms for environmental risk assessments has been banned; in other situations, the number of organisms tested has been dramatically reduced or the severity of the procedure refined. However, there is still a long way to go to achieve a complete replacement of vertebrate organisms to generate environmental hazard data. The development of animal alternatives is based not just on ethical considerations but also on reducing the cost of performing vertebrate ecotoxicity tests and in some cases on providing better information aimed at improving environmental risk assessments. The present Focus article provides an overview of the considerable advances that have been made toward alternative approaches for ecotoxicity assessments over the last few decades. (C) 2016 SETAC C1 [Lillicrap, Adam] Norwegian Inst Water Res NIVA, Oslo, Norway. [Belanger, Scott] Procter & Gamble, Global Prod Stewardship, Environm Safety & Sustainabil, Mason, OH USA. [Burden, Natalie] Natl Ctr Replacement Refinement & Reduct Anim Res, London, England. [Du Pasquier, David] WatchFrog, Evry, France. [Embry, Michelle R.] ILSI Hlth & Environm Sci, Washington, DC USA. [Halder, Marlies] European Commiss, Joint Res Ctr, Ispra, Italy. [Lee, Lucy] Univ Fraser Valley, Fac Sci, Abbotsford, BC, Canada. [Norberg-King, Teresa] US EPA, Natl Hlth & Environm Effects Lab, Off Res & Dev, Midcontinent Ecol Div Duluth, Duluth, MN USA. [Rattner, Barnett A.] US Geol Survey, Patuxent Wildlife Res Ctr, Beltsville, MD USA. [Schirmer, Kristin] Eawag Swiss Fed Inst Aquat Sci & Technol, Dubendorf, Switzerland. [Schirmer, Kristin] Swiss Fed Inst Technol, ETH Zurich, Inst Biogeochem & Pollutant Dynam, Zurich, Switzerland. [Schirmer, Kristin] EPF Lausanne, Sch Architecture Civil & Environm Engn, Lausanne, Switzerland. [Thomas, Paul] Consultancy Environm & Human Toxicol & Risk Asses, LIsle Dabeau, France. RP Lillicrap, A (reprint author), Norwegian Inst Water Res NIVA, Oslo, Norway. EM ali@niva.no OI Belanger, Scott/0000-0003-0369-9673 NR 46 TC 0 Z9 0 U1 19 U2 19 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD NOV PY 2016 VL 35 IS 11 BP 2637 EP 2646 DI 10.1002/etc.3603 PG 10 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA EA2XU UT WOS:000386461000001 PM 27779828 ER PT J AU Cantwell, MG Katz, DR Sullivan, JC Ho, K Burgess, RM Cashman, M AF Cantwell, Mark G. Katz, David R. Sullivan, Julia C. Ho, Kay Burgess, Robert M. Cashman, Michaela TI SELECTED PHARMACEUTICALS ENTERING AN ESTUARY: CONCENTRATIONS, TEMPORAL TRENDS, PARTITIONING, AND FLUXES SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Pharmaceutical; Environmental partitioning; Contaminant; Wastewater; Estuarine ID WATER TREATMENT PLANTS; WASTE-WATER; BETA-BLOCKERS; ENVIRONMENTAL RISK; SURFACE WATERS; RIVER-BASIN; SEDIMENTS; CONTAMINANTS; SORPTION; POLLUTANTS AB In many coastal watersheds and ecosystems, rivers discharging to estuaries receive waters from domestic wastewater-treatment plants resulting in the release and distribution of pharmaceuticals to the marine environment. In the present study, 15 active pharmaceutical ingredients were measured regularly over 1 yr in the dissolved and particulate phases as they entered Narragansett Bay from the Pawtuxet River in Cranston (Rhode Island, USA). Of the active pharmaceutical ingredients measured, 14 were consistently present in the dissolved phase, with concentrations ranging from below detection to >310 ng/L, whereas 8 were present in the particulate phase (0.2-18 ng/g). Partition coefficients (K(d)s and K(OC)s) were determined, and organic carbon normalization reduced variability associated with Kds for the active pharmaceutical ingredients evaluated. Flux estimates based on river flow were calculated for both dissolved and particulate-phase active pharmaceutical ingredients, with particulate fluxes being low (1-12 g/yr) and dissolved fluxes of active pharmaceutical ingredients being 155 g/yr to 11 600 g/yr. Results indicate that the pharmaceuticals measured in the present study reside primarily in the dissolved phase and thus are likely bioavailable on entering the estuarine waters of Narragansett Bay. This long-term temporal study provides important information on seasonal and annual dynamics of pharmaceuticals in an urban estuarine watershed. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US Government work and, as such, is in the public domain in the United States of America. C1 [Cantwell, Mark G.; Katz, David R.; Ho, Kay; Burgess, Robert M.] US EPA, Off Res & Dev, Narragansett, RI 02882 USA. [Sullivan, Julia C.] Oak Ridge Inst Sci & Educ, Narragansett, RI USA. [Cashman, Michaela] Univ Rhode Isl, Dept Geosci, Kingston, RI 02881 USA. RP Cantwell, MG (reprint author), US EPA, Off Res & Dev, Narragansett, RI 02882 USA. EM Cantwell.mark@epa.gov FU US Department of Energy; Environmental Protection Agency; US Environmental Protection Agency FX The present study was supported in part by an appointment to the Research Participation Program for the US Environmental Protection Agency, Office of Research and Development, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and Environmental Protection Agency. Although the research described in the present study has been wholly funded by the US Environmental Protection Agency and has been technically reviewed at the Atlantic Ecology Division, it has not been subjected to agency-level review. Therefore, it does not necessarily reflect the views of the agency. The present study is number ORD-013732 of the Atlantic Ecology Division of the US Environmental Protection Agency, Office of Research and Development, National Health Effects Environmental Research Laboratory. Mention of trade names does not constitute endorsement or recommendation for use. NR 39 TC 0 Z9 0 U1 7 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD NOV PY 2016 VL 35 IS 11 BP 2665 EP 2673 DI 10.1002/etc.3452 PG 9 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA EA2XU UT WOS:000386461000004 PM 27062058 ER PT J AU Van Meter, RJ Glinski, DA Henderson, WM Purucker, ST AF Van Meter, Robin J. Glinski, Donna A. Henderson, W. Matthew Purucker, S. Thomas TI SOIL ORGANIC MATTER CONTENT EFFECTS ON DERMAL PESTICIDE BIOCONCENTRATION IN AMERICAN TOADS (BUFO AMERICANUS) SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Amphibian; Organic matter; Pesticide; Soil ID GLYPHOSATE-BASED HERBICIDES; TERRESTRIAL ORGANISMS; ACUTE TOXICITY; AMPHIBIANS; EXPOSURE; SORPTION; USA; ACCUMULATION; CALIFORNIA; MALATHION AB Pesticides have been implicated as a major factor in global amphibian declines and may pose great risk to terrestrial phase amphibians moving to and from breeding ponds on agricultural landscapes. Dermal uptake from soil is known to occur in amphibians, but predicting pesticide availability and bioconcentration across soil types is not well understood. The present study was designed to compare uptake of 5 current-use pesticides (imidacloprid, atrazine, triadimefon, fipronil, and pendimethalin) in American toads (Bufo americanus) from exposure on soils with significant organic matter content differences (14.1% = high organic matter and 3.1% = low organic matter). We placed toads on high-or low-organic matter soil after applying individual current-use pesticides on the soil surface for an 8-h exposure duration. Whole body tissue homogenates and soils were extracted and analyzed using liquid chromatography-mass spectrometry to determine pesticide tissue and soil concentration, as well as bioconcentration factor in toads. Tissue concentrations were greater on the low-organic matter soil than the high-organic matter soil across all pesticides (average +/- standard error; 1.23 +/- 0.35 ppm and 0.78 +/- 0.23 ppm, respectively), and bioconcentration was significantly higher for toads on the low-organic matter soil (analysis of covariance p = 0.002). Soil organic matter is known to play a significant role in the mobility of pesticides and bioavailability to living organisms. Agricultural soils typically have relatively lower organic matter content and serve as a functional habitat for amphibians. The potential for pesticide accumulation in amphibians moving throughout agricultural landscapes may be greater and should be considered in conservation and policy efforts. (C) 2016 SETAC. C1 [Van Meter, Robin J.; Glinski, Donna A.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37830 USA. [Henderson, W. Matthew; Purucker, S. Thomas] US EPA, Ecosyst Res Div, Athens, GA USA. [Van Meter, Robin J.] Washington Coll, Chestertown, MD 21620 USA. RP Van Meter, RJ (reprint author), Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37830 USA.; Van Meter, RJ (reprint author), Washington Coll, Chestertown, MD 21620 USA. EM rvanmeter2@washcoll.edu FU US Department of Energy [DW8992298301]; USEPA [DW8992298301] FX Thanks to M. Cyterski for peer review and F. Rauschenberg for manuscript review and edits. Many hours of amphibian care and laboratory assistance were given by K. Washart. Our IACUC protocol (SU 14-001) received approval from the Washington College Institutional Animal Care and Use Committee. The present study was supported in part by an appointment to the Postdoctoral Research Program at the USEPA Ecosystems Research Division, Athens, Georgia, administered by the Oak Ridge Institute for Science and Education through Interagency Agreement DW8992298301 between the US Department of Energy and the USEPA. NR 56 TC 1 Z9 1 U1 15 U2 15 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD NOV PY 2016 VL 35 IS 11 BP 2734 EP 2741 DI 10.1002/etc.3439 PG 8 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA EA2XU UT WOS:000386461000011 PM 27028289 ER PT J AU Ankley, GT LaLone, CA Gray, LE Villeneuve, DL Hornung, MW AF Ankley, Gerald T. LaLone, Carlie A. Gray, L. Earl Villeneuve, Daniel L. Hornung, Michael W. TI EVALUATION OF THE SCIENTIFIC UNDERPINNINGS FOR IDENTIFYING ESTROGENIC CHEMICALS IN NONMAMMALIAN TAXA USING MAMMALIAN TEST SYSTEMS SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Prioritization; Species extrapolation; Estrogen; Hazard assessment ID ADVERSE OUTCOME PATHWAYS; ENDOCRINE DISRUPTION; RISK-ASSESSMENT; RECEPTOR-ALPHA; IN-VITRO; ENVIRONMENTAL ESTROGENS; UTEROTROPHIC BIOASSAY; AQUATIC ENVIRONMENT; SPECIES-DIFFERENCES; MOLECULAR-CLONING AB The US Environmental Protection Agency has responsibility for assessing endocrine activity of more than 10 000 chemicals, a task that cannot reasonably be achieved solely through use of available mammalian and nonmammalian in vivo screening assays. Hence, it has been proposed that chemicals be prioritized for in vivo testing using data from in vitro high-throughput assays for specific endocrine system targets. Recent efforts focused on potential estrogenic chemicals-specifically those that activate estrogen receptor-alpha (ER alpha)-have broadly demonstrated feasibility of the approach. However, a major uncertainty is whether prioritization based on mammalian (primarily human) high-throughput assays accurately reflects potential chemical-ER alpha interactions in nonmammalian species. The authors conducted a comprehensive analysis of cross-species comparability of chemical-ER alpha interactions based on information concerning structural attributes of estrogen receptors, in vitro binding and transactivation data for ER alpha, and the effects of a range of chemicals on estrogen-signaling pathways in vivo. Overall, this integrated analysis suggests that chemicals with moderate to high estrogenic potency in mammalian systems also should be priority chemicals in nonmammalian vertebrates. However, the degree to which the prioritization approach might be applicable to invertebrates is uncertain because of a lack of knowledge of the biological role(s) of possible ER alpha orthologs found in phyla such as annelids. Further, comparative analysis of in vitro data for fish and reptiles suggests that mammalian-based assays may not effectively capture ER alpha interactions for low-affinity chemicals in all vertebrate classes. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US Government work and, as such, is in the public domain in the United States of America. C1 [Ankley, Gerald T.; LaLone, Carlie A.; Villeneuve, Daniel L.; Hornung, Michael W.] US EPA, Midcontinent Ecol Div, Duluth, MN 55804 USA. [Gray, L. Earl] US EPA, Tox Assessment Div, Res Triangle Pk, NC 27711 USA. RP Ankley, GT (reprint author), US EPA, Midcontinent Ecol Div, Duluth, MN 55804 USA. EM ankley.gerald@epa.gov NR 67 TC 2 Z9 2 U1 8 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD NOV PY 2016 VL 35 IS 11 BP 2806 EP 2816 DI 10.1002/etc.3456 PG 11 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA EA2XU UT WOS:000386461000019 PM 27074246 ER PT J AU Silvestri, EE Feldhake, D Griffin, D Lisle, J Nichols, TL Shah, SR Pemberton, A Schaefer, FW AF Silvestri, Erin E. Feldhake, David Griffin, Dale Lisle, John Nichols, Tonya L. Shah, Sanjiv R. Pemberton, Adin Schaefer, Frank W., III TI Optimization of a sample processing protocol for recovery of Bacillus anthracis spores from soil SO JOURNAL OF MICROBIOLOGICAL METHODS LA English DT Article DE Bacillus anthracis; Spores; Sand; Loam; Soil; Indirect processing ID LONG-CHAIN POLYPHOSPHATES; DNA EXTRACTION; SODIUM HEXAMETAPHOSPHATE; PATHOGENIC BACTERIA; PCR; AGENTS AB Following a release of Bacillus anthracis spores into the environment, there is a potential for lasting environmental contamination in soils. There is a need for detection protocols for B. anthracis in environmental matrices. However, identification of B. anthracis within a soil is a difficult task. Processing soil samples helps to remove debris, chemical components, and biological impurities that can interfere with microbiological detection. This study aimed to optimize a previously used indirect processing protocol, which included a series of washing and centrifugation steps. Optimization of the protocol included: identifying an ideal extraction diluent, variation in the number of wash steps, variation in the initial centrifugation speed, sonication and shaking mechanisms. The optimized protocol was demonstrated at two laboratories in order to evaluate the recovery of spores from loamy and sandy soils. The new protocol demonstrated an improved limit of detection for loamy and sandy soils over the non-optimized protocol with an approximate matrix limit of detection at 14 spores/g of soil. There were no significant differences overall between the two laboratories for either soil type, suggesting that the processing protocol will be robust enough to use at multiple laboratories while achieving comparable recoveries. Published by Elsevier B.V. C1 [Silvestri, Erin E.; Schaefer, Frank W., III] US EPA, Natl Homeland Secur Res Ctr, 26 W Martin Luther King Dr,MS NG16, Cincinnati, OH 45268 USA. [Feldhake, David; Pemberton, Adin] Pegasus Tech Serv Inc, 46 East Hollister St, Cincinnati, OH 45219 USA. [Griffin, Dale; Lisle, John] US Geol Survey, Coastal & Marine Sci Ctr, 600 4th St South, St Petersburg, FL 33701 USA. [Nichols, Tonya L.; Shah, Sanjiv R.] US EPA, Natl Homeland Secur Res Ctr, 1200 Penn Ave NW,MS 8801R, Washington, DC 20460 USA. RP Griffin, D (reprint author), US Geol Survey, Coastal & Marine Sci Ctr, 600 4th St South, St Petersburg, FL 33701 USA. EM Silvestri.Erin@epa.gov; Feldhake.David@epa.gov; dgriffin@usgs.gov; jlisle@usgs.gov; Nichols.Tonya@epa.gov; Shah.Sanjiv@epa.gov; Pemberton.Adin@epa.gov; fschaefer@zoomtown.com FU EPA [EP-C-11-006]; Office of Research and Development FX The U.S. Environmental Protection Agency, through its Office of Research and Development, funded, managed, and collaborated in the research described here under an Interagency Agreement with the U.S. Geological Survey (IA #DW 14957748 and DW 92401101) and through Pegasus Technical Services, Inc., a contractor to the EPA (Contract # EP-C-11-006). It has been subjected to the Agency's review and has been approved for publication. Note that approval does not signify that the contents necessarily reflect the views of the Agency. This article has been peer reviewed and approved for publication consistent with USGS Fundamental Science Practices (http://pubs.usgs.gov/circ/1367/). Mention of trade names, products, or services is for descriptive purposes only and does not convey U.S. Government approval, endorsement, or recommendation. NR 42 TC 0 Z9 0 U1 3 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-7012 EI 1872-8359 J9 J MICROBIOL METH JI J. Microbiol. Methods PD NOV PY 2016 VL 130 BP 6 EP 13 DI 10.1016/j.mimet.2016.08.013 PG 8 WC Biochemical Research Methods; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA EA2EZ UT WOS:000386406900002 PM 27546718 ER PT J AU Cashdollar, JL Huff, E Ryu, H Grimm, AC AF Cashdollar, Jennifer L. Huff, Emma Ryu, Hodon Grimm, Ann C. TI The influence of incubation time on adenovirus quantitation in A549 cells by most probable number SO JOURNAL OF VIROLOGICAL METHODS LA English DT Article DE Adenovirus; Cell culture; UV treatment; Virus recovery; Adenovirus quantitation; Adenovirus disinfection ID TREATED DRINKING-WATER; UV DISINFECTION; PCR; INACTIVATION; INFECTION; ASSAYS; LINES; DNA AB Cell culture based assays used to detect waterborne viruses typically call for incubating the sample for at least two weeks in order to ensure that all the culturable virus present is detected. Historically, this estimate was based, at least in part, on the length of time used for detecting poliovirus. In this study, we have examined A549 cells infected with human adenovirus type 2, and have found that a three week incubation of virus infected cells results in a higher number of detected viruses by quantal assay than what is seen after two weeks of incubation, with an average 955% increase in Most Probable Number (MPN) from 2 weeks to 3 weeks. This increase suggests that the extended incubation time is essential for accurately estimating viral titer, particularly for slow-growing viruses, UV treated samples, or samples with low titers of virus. In addition, we found that for some UV-treated samples, there was no detectable MPN at 2 weeks, but after 3 weeks, MPN values were obtained. For UV-treated samples, the average increase in MPN from 2 weeks to 3 weeks was 1401%, while untreated samples averaged a change in MPN of 674%, leading us to believe that the UV-damaged viral DNA may be able to be repaired such that viral replication then occurs. Published by Elsevier B.V. C1 [Cashdollar, Jennifer L.; Grimm, Ann C.] US EPA, Natl Exposure Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA. [Huff, Emma] US EPA, Student Serv Contractor, Cincinnati, OH 45268 USA. [Ryu, Hodon] US EPA, Natl Risk Management Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA. RP Cashdollar, JL (reprint author), 26 W ML King Dr, Cincinnati, OH 45013 USA. EM cashdollar.jennifer@epa.gov FU United States Environmental Protection Agency, through its Office of Research and Development FX The authors wish to thank Jenifer Jones for technical assistance, and Dr. Eric Rhodes and Jeff Adams for technical review of this manuscript. The United States Environmental Protection Agency, through its Office of Research and Development, has funded and managed the research described herein. This work has been subjected to the agency's administrative review and has been approved for external publication. Any opinions expressed in this paper are those of the authors and do not necessarily reflect the views of the agency; therefore, no official endorsement should be inferred. NR 25 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-0934 EI 1879-0984 J9 J VIROL METHODS JI J. Virol. Methods PD NOV PY 2016 VL 237 BP 200 EP 203 DI 10.1016/j.jviromet.2016.09.002 PG 4 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Virology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Virology GA DZ9JH UT WOS:000386190700032 PM 27596270 ER PT J AU Baseley, D Wunderlich, L Phillips, G Gross, K Perram, G Willison, S Phillips, R Magnuson, M Lee, SD Harper, WF AF Baseley, Daniel Wunderlich, Luke Phillips, Grady Gross, Kevin Perram, Glen Willison, Stuart Phillips, Rebecca Magnuson, Matthew Lee, Sang Don Harper, Willie F., Jr. TI Hyperspectral analysis for standoff detection of dimethyl methylphosphonate on building materials SO BUILDING AND ENVIRONMENT LA English DT Article DE Hyperspectral imaging; Organophosphate; Contrast angle; Surface analysis; Decontamination ID PESTICIDES; SPECTRA; CONTAMINATION; EXPOSURES; HEALTH; CANCER; RISK; AIR AB Detecting organophosphates in indoor settings can greatly benefit from more efficient and faster methods of surveying large surface areas than conventional approaches, which sample small surface areas followed by extraction and analysis. This study examined a standoff detection technique utilizing hyperspectral imaging for analysis of building materials in near-real time. In this proof-of-concept study, dimethyl methylphosphonate (DMMP) was applied to stainless steel and laminate coupons and spectra were collected during active illumination. Absorbance bands at approximately 1275 cm(-1) and 1050 cm(-1) were associated with phosphorus-oxygen double bond (P=O) and phosphorus-oxygen-carbon (P-O-C) bond stretches of DMMP, respectively. The magnitude of these bands increased linearly (r(2) = 0.93) with DMMP across the full absorbance spectrum, between v(1) = 877 cm(-1) to v(2) = 1262 cm(-1). Comparisons between bare and contaminated surfaces on stainless steel using the spectral contrast angle technique indicated that the bare samples showed no sign of contamination, with large uniformly distributed contrast angles of 45 degrees-55 degrees, while the contaminated samples had smaller spectral contact angles of <20 degrees in the contaminated region and >40 degrees in the uncontaminated region. The laminate contaminated region exhibited contact angles of <25 degrees. To the best of our knowledge, this is the first report to demonstrate that hyperspectral imaging can be used to detect DMMP on building materials, with detection levels similar to concentrations expected for some organophosphate deposition scenarios. Published by Elsevier Ltd. C1 [Baseley, Daniel; Harper, Willie F., Jr.] US Air Force, Inst Technol, Dept Syst Engn & Management, 2950 Hobson Way, Wright Patterson AFB, OH 45433 USA. [Wunderlich, Luke] Wright State Univ, Dept Biomed Engn, Dayton, OH 45435 USA. [Phillips, Grady; Gross, Kevin; Perram, Glen] US Air Force, Inst Technol, Dept Engn Phys, 2950 Hobson Way, Wright Patterson AFB, OH 45433 USA. [Willison, Stuart; Phillips, Rebecca; Magnuson, Matthew; Lee, Sang Don] US EPA, Natl Homeland Secur Res Ctr, 26 W Martin Luther King Dr,Mailstop NG-16, Cincinnati, OH 45268 USA. RP Harper, WF (reprint author), US Air Force, Inst Technol, Dept Syst Engn & Management, 2950 Hobson Way, Wright Patterson AFB, OH 45433 USA. EM willie.harper@afit.edu FU U.S. Environmental Protection Agency through its Office of Research and Development [DW-57-92390501] FX The U.S. Environmental Protection Agency through its Office of Research and Development partially funded and collaborated in the research described here under Interagency Agreement DW-57-92390501. It has been subjected to the Agency's review and has been approved for publication. The authors thank Kelley Robinson (AFIT) and John Hixenbaugh (AFIT) for logistical assistance. We thank Dr. Daniel Felker (Analytical Chemist, AFIT) for experimental assistance. NR 29 TC 0 Z9 0 U1 2 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0360-1323 EI 1873-684X J9 BUILD ENVIRON JI Build. Environ. PD NOV 1 PY 2016 VL 108 BP 135 EP 142 DI 10.1016/j.buildenv.2016.08.028 PG 8 WC Construction & Building Technology; Engineering, Environmental; Engineering, Civil SC Construction & Building Technology; Engineering GA DY7QL UT WOS:000385324300012 ER PT J AU Kim, YH Krantz, QT McGee, J Kovalcik, KD Duvall, RM Willis, RD Kamal, AS Landis, MS Norris, GA Gilmour, MI AF Kim, Yong Ho Krantz, Q. Todd McGee, John Kovalcik, Kasey D. Duvall, Rachelle M. Willis, Robert D. Kamal, Ali S. Landis, Matthew S. Norris, Gary A. Gilmour, M. Ian TI Chemical composition and source apportionment of size fractionated particulate matter in Cleveland, Ohio, USA SO ENVIRONMENTAL POLLUTION LA English DT Article DE Cleveland airshed; Particulate matter; Positive matrix factorization; Source apportionment ID POSITIVE MATRIX FACTORIZATION; AIR-POLLUTION; UTAH-VALLEY; DAILY MORTALITY; ESTIMATING UNCERTAINTY; HOSPITAL ADMISSIONS; UNITED-STATES; RURAL SITES; TIME-SERIES; AMBIENT AIR AB The Cleveland airshed comprises a complex mixture of industrial source emissions that contribute to periods of non-attainment for fine particulate matter (PM2.5) and are associated with increased adverse health outcomes in the exposed population. Specific PM sources responsible for health effects however are not fully understood. Size-fractionated PM (coarse, fine, and ultrafine) samples were collected using a ChemVol sampler at an urban site (G.T. Craig (GTC)) and rural site (Chippewa Lake (CLM)) from July 2009 to June 2010, and then chemically analyzed. The resulting speciated PM data were apportioned by EPA positive matrix factorization to identify emission sources for each size fraction and location. For comparisons with the ChemVol results, PM samples were also collected with sequential dichotomous and passive samplers, and evaluated for source contributions to each sampling site. The ChemVol results showed that annual average concentrations of PM, elemental carbon, and inorganic elements in the coarse fraction at GTC were 2, 7, and 3 times higher than those at CLM, respectively, while the smaller size fractions at both sites showed similar annual average concentrations. Seasonal variations of secondary aerosols (e.g., high NO3- level in winter and high SO42- level in summer) were observed at both sites. Source apportionment results demonstrated that the PM samples at GTC and CLM were enriched with local industrial sources (e.g., steel plant and coal-fired power plant) but their contributions were influenced by meteorological conditions and the emission source's operation conditions. Taken together the year-long PM collection and data analysis provides valuable insights into the characteristics and sources of PM impacting the Cleveland airshed in both the urban center and the rural upwind background locations. These data will be used to classify the PM samples for toxicology studies to determine which PM sources, species, and size fractions are of greatest health concern. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Kim, Yong Ho; Krantz, Q. Todd; McGee, John; Gilmour, M. Ian] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Kovalcik, Kasey D.; Duvall, Rachelle M.; Willis, Robert D.; Kamal, Ali S.; Landis, Matthew S.] US EPA, Exposure Methods & Measurement Div, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Norris, Gary A.] US EPA, Syst Exposure Div, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Kim, Yong Ho] CNR, Washington, DC 20001 USA. RP Gilmour, MI (reprint author), US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. EM gilmour.ian@epa.gov NR 61 TC 0 Z9 0 U1 17 U2 17 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0269-7491 EI 1873-6424 J9 ENVIRON POLLUT JI Environ. Pollut. PD NOV PY 2016 VL 218 BP 1180 EP 1190 DI 10.1016/j.envpol.2016.08.073 PG 11 WC Environmental Sciences SC Environmental Sciences & Ecology GA DZ1JZ UT WOS:000385596000129 PM 27593352 ER PT J AU Dhar, BR Ryu, H Domingo, JWS Lee, HS AF Dhar, Bipro Ranjan Ryu, Hodon Domingo, Jorge W. Santo Lee, Hyung-Sool TI Ohmic resistance affects microbial community and electrochemical kinetics in a multi-anode microbial electrochemical cell SO JOURNAL OF POWER SOURCES LA English DT Article DE Anode potential; Geobacter; Half-saturation anode potential; Microbial electrochemical cells; Multi-anode; Ohmic energy loss ID ANODE-RESPIRING BACTERIA; WASTE-WATER TREATMENT; FUEL-CELLS; ELECTRICITY-GENERATION; AEROMONAS-HYDROPHILA; ELECTROLYSIS CELLS; CARBON NANOTUBE; BIOFILM ANODE; PERFORMANCE; POTENTIALS AB Multi-anode microbial electrochemical cells (MxCs) are considered as one of the most promising configurations for scale-up of MxCs, but understanding of anode kinetics in multiple anodes is limited in the MxCs. In this study we assessed microbial community and electrochemical kinetic parameters for bio-films on individual anodes in a multi-anode MxC to better comprehend anode fundamentals. Microbial community analysis targeting 16S rRNA Illumina sequencing showed that Geobacter genus was abundant (87%) only on the biofilm anode closest to a reference electrode (low ohmic energy loss) in which current density was the highest among three anodes. In comparison, Geobacter populations were less than 1% for biofilms on other two anodes distant from the reference electrode (high ohmic energy loss), generating small current density. Half-saturation anode potential (E-KA) was the lowest at -0.251 to -0.242 V (vs. standard hydrogen electrode) for the closest biofilm anode to the reference electrode, while E-KA was as high as -0.134 V for the farthest anode. Our study proves that electric potential of individual anodes changed by ohmic energy loss shifts biofilm communities on individual anodes and consequently influences electron transfer kinetics on each anode in the multi-anode MxC. (C) 2016 Elsevier B.V. All rights reserved. C1 [Dhar, Bipro Ranjan; Lee, Hyung-Sool] Univ Waterloo, Dept Civil & Environm Engn, 200 Univ Ave West, Waterloo, ON N2L 3G1, Canada. [Ryu, Hodon; Domingo, Jorge W. Santo] US EPA, Natl Risk Management Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. RP Lee, HS (reprint author), Univ Waterloo, Dept Civil & Environm Engn, 200 Univ Ave West, Waterloo, ON N2L 3G1, Canada. EM hyungsool@uwaterloo.ca FU Natural Sciences and Engineering Research Council of Canada [STPGP 478972]; U.S. Environmental Protection Agency, through its Office of Research and Development FX We thank Michael Elk for technical assistance. We also thank Dr. Junyoung An and Dr. Elsayed Elbeshbishy for their comments on experimental plan and fabrication of a reactor. This work was financially supported by Natural Sciences and Engineering Research Council of Canada (STPGP 478972). The U.S. Environmental Protection Agency, through its Office of Research and Development, partially funded this research. This work has been subjected to the agency's administrative review and has been approved for external publication. Any opinions expressed in this paper are those of the authors and do not necessarily reflect the views of the agency; therefore, no official endorsement should be inferred. Any mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 47 TC 0 Z9 0 U1 16 U2 16 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 EI 1873-2755 J9 J POWER SOURCES JI J. Power Sources PD NOV 1 PY 2016 VL 331 BP 315 EP 321 DI 10.1016/j.jpowsour.2016.09.055 PG 7 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA DZ1LZ UT WOS:000385601200035 ER PT J AU Fulford, RS Russell, M Rogers, JE AF Fulford, R. S. Russell, M. Rogers, J. E. TI Habitat Restoration from an Ecosystem Goods and Services Perspective: Application of a Spatially Explicit Individual-Based Model SO ESTUARIES AND COASTS LA English DT Article DE Model; Ecosystem goods and services; Seatrout; Seagrass; Estuaries ID SOUTHEASTERN UNITED-STATES; SPOTTED SEA-TROUT; FISH PRODUCTION; POPULATION-DYNAMICS; SEAGRASS ECOSYSTEM; ECOLOGICAL MODEL; SALT MARSHES; TAMPA BAY; MOVEMENT; FLORIDA AB Estuarine ecosystems provide many services to humans, but these ecosystems are also under pressure from human development, which has led to large investments in habitat protection and restoration. Restoration in estuaries is typically focused on emergent and submerged vegetation with the goal of achieving target areal coverage based on historic conditions. Such restoration targets assume no spatial heterogeneity in habitat value and bypass the functional target of restoring or maintaining delivery of ecosystem goods and services (EGS). We have developed a spatially explicit individual-based behavioral model intended to explore the functional role of habitat restoration on EGS delivery in an index system (Tampa Bay, FL) and for an index EGS (recreational fishing). Model scenarios are based on interaction of inter-annual differences in salinity/temperature patterns (wet, dry, average) with hindcasted "increases" in coverage and distribution of seagrass. Model predictions indicated that the effect of seagrass restoration to historic (1950s) levels on both fish and fishery production is dependent on salinity and temperature. This dependence is based on predicted fish response both to habitat changes and the effective spatial scale of different habitat components. Overall, average salinity/temperature conditions facilitated the highest positive functional response to seagrass restoration with extreme wet/dry years yielding lower or even negative functional responses, but these responses were localized and not homogenous about the estuary. The results of this study provide a methodology for using functional targets in restoration planning and highlight the importance of considering the entire habitat mosaic in valuing restored habitat from an EGS perspective. C1 [Fulford, R. S.; Russell, M.; Rogers, J. E.] US EPA, Gulf Ecol Div, 1 Sabine Isl Rd, Gulf Breeze, FL 32561 USA. RP Fulford, RS (reprint author), US EPA, Gulf Ecol Div, 1 Sabine Isl Rd, Gulf Breeze, FL 32561 USA. EM Fulford.Richard@epa.gov NR 62 TC 0 Z9 0 U1 20 U2 20 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1559-2723 EI 1559-2731 J9 ESTUAR COAST JI Estuaries Coasts PD NOV PY 2016 VL 39 IS 6 BP 1801 EP 1815 DI 10.1007/s12237-016-0100-6 PG 15 WC Environmental Sciences; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA DY4AR UT WOS:000385041900018 ER PT J AU Oczkowski, A Hunt, CW Miller, K Oviatt, C Nixon, S Smith, L AF Oczkowski, Autumn Hunt, Christopher W. Miller, Kenneth Oviatt, Candace Nixon, Scott Smith, Leslie TI Comparing Measures of Estuarine Ecosystem Production in a Temperate New England Estuary SO ESTUARIES AND COASTS LA English DT Article DE pH; Dissolved oxygen; Production; Estuary; Eutrophication; Nutrients; Ecosystem ID SEA-LEVEL RISE; NARRAGANSETT BAY; NUTRIENT ENRICHMENT; GAS-EXCHANGE; PHYTOPLANKTON BIOMASS; OCEAN ACIDIFICATION; GROWTH-RATE; COASTAL; CHLOROPHYLL; EUTROPHICATION AB Anthropogenic nutrient enrichments and concerted efforts at nutrient reductions, compounded with the influences of climate change, are likely changing the net ecosystem production (NEP) of our coastal systems. To quantify these changes, scientists monitor a range of physical, chemical, and biological parameters sampled at various frequencies. Water column chlorophyll concentrations are arguably the most commonly used indicator of net phytoplankton production, as well as a coarse indicator of NEP. We compared parameters that estimate production, including chlorophyll, across an experimental nutrient gradient and in situ in both well-mixed and stratified estuarine environments. Data from an experiment conducted in the early 1980s in mesocosms designed to replicate a well-mixed mid-Narragansett Bay (Rhode Island) water column were used to correlate changes in chlorophyll concentrations, pH, dissolved oxygen (O-2), dissolved inorganic nitrogen, phosphate, and silicate concentrations, cell counts, and C-14 carbon uptake measurements across a range of nutrient enrichments. The pH, O-2, nutrient, and cell count measurements reflected seasonal cycles of spring blooms followed by late summer/early fall respiration periods across nutrient enrichments. Chlorophyll concentrations were more variable and rates of C-14 productivity were inconsistent with observed trends in nutrient concentrations, pH, and O-2 concentrations. Similar comparisons were made using data from a well-mixed lower Narragansett Bay station and a more stratified upper Narragansett Bay station in 2007 and 2008. Trends among pH, O-2, and nutrient concentration parameters were similar to those observed in the mesocosm dataset, suggesting that continuous free water measurements of pH and O-2 seem to reliably reflect ecosystem metabolism and, while not perfect measures, may be underused indicators of NEP. C1 [Oczkowski, Autumn] US EPA, Atlantic Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA. [Hunt, Christopher W.] Univ New Hampshire, Ocean Proc Anal Lab, Durham, NH 03824 USA. [Miller, Kenneth] CSC, 6361 Walker Lane,Suite 300, Alexandria, VA 22310 USA. [Oviatt, Candace; Nixon, Scott] Univ Rhode Isl, Grad Sch Oceanog, Narragansett, RI 02882 USA. [Smith, Leslie] Your Ocean Consulting LLC, 9924 Rainbow Dr, Knoxville, TN 37922 USA. RP Oczkowski, A (reprint author), US EPA, Atlantic Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA. EM oczkowski.autumn@epa.gov OI Hunt, Christopher/0000-0001-8061-4560 FU US Environmental Protection Agency FX We would like to thank all of the scientists and support staff who contributed to the MERL mesocosm experiments and the development of such thorough datasets that are still used, even after 30 years. The manuscript was improved by feedback from Dr. Jason Grear, Dr. Richard Pruell, Roxanne Johnson, and three anonymous reviewers. This is ORD Tracking Number ORD-013005 of the Atlantic Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency. Although the research described in this article has been funded in part by the US Environmental Protection Agency, it has not been subjected to Agency review. Therefore, it does not necessarily reflect the views of the Agency. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 96 TC 0 Z9 0 U1 20 U2 20 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1559-2723 EI 1559-2731 J9 ESTUAR COAST JI Estuaries Coasts PD NOV PY 2016 VL 39 IS 6 BP 1827 EP 1844 DI 10.1007/s12237-016-0113-1 PG 18 WC Environmental Sciences; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA DY4AR UT WOS:000385041900020 ER PT J AU van Groos, PGK Kaplan, DI Chang, HS Seaman, JC Li, D Peacock, AD Scheckel, KG Jaffe, PR AF van Groos, Paul G. Koster Kaplan, Daniel I. Chang, Hyun-shik Seaman, John C. Li, Dien Peacock, Aaron D. Scheckel, Kirk G. Jaffe, Peter R. TI Uranium fate in wetland mesocosms: Effects of plants at two iron loadings with different pH values SO CHEMOSPHERE LA English DT Article DE Uranium fate; Uranium sequestration; Wetlands; Iron; Rhizosphere; Plants ID NATURAL ORGANIC-MATTER; SAVANNA RIVER SITE; MICROBIAL REDUCTION; REDUCING CONDITIONS; DISSOLVED-OXYGEN; IMMOBILIZATION; ROOTS; BIOREDUCTION; REOXIDATION; SPECIATION AB Small-scale continuous flow wetland mesocosms (similar to 0.8 L) were used to evaluate how plant roots under different iron loadings affect uranium (U) mobility. When significant concentrations of ferrous iron (Fe) were present at circumneutral pH values, U concentrations in root exposed sediments were an order of magnitude greater than concentrations in root excluded sediments. Micro X-ray absorption near-edge structure (mu-XANES) spectroscopy indicated that U was associated with the plant roots primarily as U(VI) or U(V), with limited evidence of U(IV). Micro X-ray fluorescence (1.1.-XRF) of plant roots suggested that for high iron loading at circumneutral pH, U was co-located with Fe, perhaps co-precipitated with root Fe plaques, while for low iron loading at a pH of similar to 4 the correlation between U and Fe was not significant, consistent with previous observations of U associated with organic matter. Quantitative PCR analyses indicated that the root exposed sediments also contained elevated numbers of Geobacter spp., which are likely associated with enhanced iron cycling, but may also reduce mobile U(VI) to less mobile U(IV) species. (C) 2016 Elsevier Ltd. All rights reserved. C1 [van Groos, Paul G. Koster; Jaffe, Peter R.] Princeton Univ, Princeton, NJ 08540 USA. [Kaplan, Daniel I.; Li, Dien] Savannah River Natl Lab, Aiken, SC 29808 USA. [Chang, Hyun-shik; Seaman, John C.] Univ Georgia, Savannah River Ecol Lab, Aiken, SC 29802 USA. [Peacock, Aaron D.] Pace Analyt Energy Serv, Pittsburgh, PA 15238 USA. [Scheckel, Kirk G.] US EPA, Cincinnati, OH 45268 USA. [van Groos, Paul G. Koster] CB&I Fed Serv, Biotechnol Dev & Applicat Grp, 17 Princess Rd, Lawrenceville, NJ 08648 USA. RP Jaffe, PR (reprint author), Princeton Univ, Princeton, NJ 08540 USA. EM jaffe@princeton.edu OI Scheckel, Kirk/0000-0001-9326-9241 FU National Science Foundation - Earth Sciences [EAR-1128799]; Department of Energy - GeoSciences [DE-FG02-94ER14466]; DOE Office of Science [DE-AC02-06CH11357]; United States Department of Energy's (DOE) Subsurface Biogeochemistry Research program [DE-SC0006847]; DOE [DE-AC09-96SR18500]; Savannah River Ecology Laboratory through a Financial Assistance Award from DOE [DE-FC09-07SR22506] FX Portions of this work were performed at GeoSoilEnviroCARS (Sector 13), Advanced Photon Source (APS), Argonne National Laboratory. GeoSoilEnviroCARS is supported by the National Science Foundation - Earth Sciences (EAR-1128799) and Department of Energy - GeoSciences (DE-FG02-94ER14466). This research used resources of the Advanced Photon Source, a U.S. Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under Contract No. DE-AC02-06CH11357. We are grateful for the assistance of Matthew Newville and Antonio Lanzirotti at Argonne National Laboratory's Advanced Photon Source for facilitating the X-ray absorption spectroscopy. We are also grateful for assistance from Matthew Reid and Shan Huang from Princeton University regarding experimental design and sampling. The research described in this paper was funded by the United States Department of Energy's (DOE) Subsurface Biogeochemistry Research program, Contract DE-SC0006847. Work was conducted at the Savannah River National Laboratory under the DOE contract DE-AC09-96SR18500. Participation of Drs. J. C. Seaman and H. S. Chang were supported by the Savannah River Ecology Laboratory through a Financial Assistance Award DE-FC09-07SR22506 from DOE to the University of Georgia's Research Foundation. Although the U.S. Environmental Protection Agency (EPA) contributed to this article, the research presented was not directly performed by or funded by EPA and was not subject to EPA's quality system requirements. Consequently, the views, interpretations, and conclusions expressed in this article are solely those of the authors and do not necessarily reflect or represent EPA's views or policies. NR 41 TC 0 Z9 0 U1 17 U2 17 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD NOV PY 2016 VL 163 BP 116 EP 124 DI 10.1016/j.chemosphere.2016.08.012 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA DY0HB UT WOS:000384776800015 ER PT J AU Csiszar, SA Ernstoff, AS Fantke, P Meyer, DE Jolliet, O AF Csiszar, Susan A. Ernstoff, Alexi S. Fantke, Peter Meyer, David E. Jolliet, Olivier TI High-throughput exposure modeling to support prioritization of chemicals in personal care products SO CHEMOSPHERE LA English DT Article DE Exposure modeling; Personal care products; Mass balance modeling; Product intake fraction; Risk screening; High-throughput ID IN-VITRO BIOACTIVITY; RISK-ASSESSMENT; MANUFACTURED CHEMICALS; COSMETIC PRODUCTS; INDOOR AIR; DOSIMETRY; SHAMPOO; WASH AB We demonstrate the application of a high-throughput modeling framework to estimate exposure to chemicals used in personal care products (PCPs). As a basis for estimating exposure, we use the product intake fraction (PiF), defined as the mass of chemical taken by an individual or population per mass of a given chemical used in a product. We calculated use- and disposal- stage PiFs for 518 chemicals for five PCP archetypes. Across all product archetypes the use- and disposal- stage PiFs ranged from 10(-5) to 1 and 0 to 10(-3), respectively. There is a distinction between the use-stage PiF for leave-on and wash-off products which had median PiFs of 0.5 and 0.02 across the 518 chemicals, respectively. The PiF is a function of product characteristics and physico-chemical properties and is maximized when skin permeability is high and volatility is low such that there is no competition between skin and air losses from the applied product. PCP chemical contents (i.e. concentrations) were available for 325 chemicals and were combined with PCP usage characteristics and PiF yielding intakes summed across a demonstrative set of products ranging from 10(-8)-30 mg/kg/d, with a median of 0.1 mg/kg/d. The highest intakes were associated with body lotion. Bioactive doses derived from high-throughput in vitro toxicity data were combined with the estimated PiFs to demonstrate an approach to estimate bioactive equivalent chemical content and to screen chemicals for risk. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Csiszar, Susan A.] US EPA, Res Participat Program, ORISE, Cincinnati, OH 45268 USA. [Ernstoff, Alexi S.; Fantke, Peter] Tech Univ Denmark, Quantitat Sustainabil Assessment Div, Dept Engn Management, Lyngby, Denmark. [Meyer, David E.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Jolliet, Olivier] Univ Michigan, Sch Publ Hlth, Environm Hlth Sci, Ann Arbor, MI 48109 USA. RP Jolliet, O (reprint author), Univ Michigan, Sch Publ Hlth, Environm Hlth Sci, Ann Arbor, MI 48109 USA.; Csiszar, SA (reprint author), ORISE, Res Participat Program, Oak Ridge, TN 37831 USA. EM susan.csiszar@gmail.com; ojolliet@umich.edu OI Ernstoff, Alexi/0000-0002-1114-6596; Fantke, Peter/0000-0001-7148-6982 FU U.S. EPA [EP-14-C-000115]; Long Range Research Initiative of the American Chemistry Council; European Commission [631910, 285286] FX We thank Kristin Isaacs (U.S. EPA) for the CPCPdb product category information. We thank Deborah Bennett (University of California, Davis) for helpful comments and discussion. Funding for the University of Michigan work was provided by U.S. EPA contract EP-14-C-000115 on Development of Modular Risk Pathway Descriptions for Life Cycle Assessment, and the Long Range Research Initiative of the American Chemistry Council. P. Fantke was supported by the Marie Curie projects Quan-Tox (GA No. 631910) and Tox-Train (GA No. 285286) funded by the European Commission under the Seventh Framework Programme. NR 40 TC 1 Z9 1 U1 11 U2 11 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD NOV PY 2016 VL 163 BP 490 EP 498 DI 10.1016/j.chemosphere.2016.07.065 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA DY0HB UT WOS:000384776800056 PM 27565317 ER PT J AU Kaplan, DI Kukkadapu, R Seaman, JC Arey, BW Dohnalkova, AC Buettner, S Li, D Varga, T Scheckel, KG Jaffe, PR AF Kaplan, Daniel I. Kukkadapu, Ravi Seaman, John C. Arey, Bruce W. Dohnalkova, Alice C. Buettner, Shea Li, Dien Varga, Tamas Scheckel, Kirk G. Jaffe, Peter R. TI Iron mineralogy and uranium-binding environment in the rhizosphere of a wetland soil SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Root; X-ray absorption spectroscopy; Iron nanoparticles; Mssbauer ID RAY-ABSORPTION-SPECTROSCOPY; NATURAL ORGANIC-MATTER; FRESH-WATER WETLANDS; PHRAGMITES-AUSTRALIS; WATERLOGGING TOLERANCE; RICE ROOTS; FE-PLAQUE; SEDIMENTS; REDUCTION; MANGANESE AB Wetlands mitigate the migration of groundwater contaminants through a series of biogeochemical gradients that enhance multiple contaminant-binding processes. The hypothesis of this study was that wetland plant roots contribute organic carbon and release O-2 within the rhizosphere (plant-impact soil zone) that promote the formation of Fe(III)-(oxyhydr) oxides. In turn, these Fe(III)-(oxyhydr) oxides stabilize organic matter that together contribute to contaminant immobilization. Mineralogy and U binding environments of the rhizosphere were evaluated in samples collected from contaminated and non-contaminated areas of a wetland on the Savannah River Site in South Carolina. Based on Mossbauer spectroscopy, rhizosphere soil was greatly enriched with nanogoethite, ferrihydrite-like nanoparticulates, and hematite, with negligible Fe(II) present. X-ray computed tomography and various microscopy techniques showed that root plaques were tens-of-microns thick and consisted of highly oriented Fe-nanoparticles, suggesting that the roots were involved in creating the biogeochemical conditions conducive to the nanoparticle formation. XAS showed that a majority of the U in the bulk wetland soil was in the + 6 oxidation state and was not well correlated spatially to Fe concentrations. SEM/EDS confirm that U was enriched on root plaques, where it was always found in association with P. Together these findings support our hypothesis and suggest that plants can alter mineralogical conditions that may be conducive to contaminant immobilization in wetlands. (C) 2016 Elsevier B.V. All rights reserved. C1 [Kaplan, Daniel I.; Li, Dien] Savannah River Natl Lab, Aiken, SC 29808 USA. [Kukkadapu, Ravi; Arey, Bruce W.; Dohnalkova, Alice C.; Varga, Tamas] Pacific Northwest Natl Lab, Environm Mol Sci Lab, Richland, WA 99354 USA. [Seaman, John C.; Buettner, Shea] Univ Georgia, Savannah River Ecol Lab, Aiken, SC 29802 USA. [Scheckel, Kirk G.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45224 USA. [Jaffe, Peter R.] Princeton Univ, Princeton, NJ 08540 USA. RP Kaplan, DI (reprint author), Savannah River Natl Lab, Aiken, SC 29808 USA. EM daniel.kaplan@srnl.doe.gov OI Scheckel, Kirk/0000-0001-9326-9241 FU Subsurface Biogeochemistry Research Program within the Office of Biological and Environmental Research (OBER), Office of Science, U.S. Department of Energy [DR-FG02-08ER64567, ER65222-1038426-0017532]; U.S. DOE Office of Science, Office of Basic Energy Sciences [W-31-109-ENG-38]; U.S. Department of Energy [DE-SC0006847]; EPA FX This work was supported by the Subsurface Biogeochemistry Research Program within the Office of Biological and Environmental Research (OBER), Office of Science, U.S. Department of Energy, Grants DR-FG02-08ER64567 and ER65222-1038426-0017532. Mossbauer spectroscopy, XCT, TEM, He-IM, and SEM/EDS were conducted at EMSL, a national scientific user facility sponsored by DOE's OBER program. EMSL is located at the PNNL in Richland, WA, USA. Use of Advance Photon Source was supported by the U.S. DOE Office of Science, Office of Basic Energy Sciences, under contract No. W-31-109-ENG-38. Work was conducted at Princeton University under the U.S. Department of Energy Contract DE-SC0006847. Although EPA contributed to this article, the research presented was not directly performed by or funded by EPA and was not subject to EPA's quality system requirements. Consequently, the views, interpretations, and conclusions expressed in this article are solely those of the authors and do not necessarily reflect or represent EPA's views or policies. NR 60 TC 0 Z9 0 U1 46 U2 46 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD NOV 1 PY 2016 VL 569 BP 53 EP 64 DI 10.1016/j.scitotenv.2016.06.120 PG 12 WC Environmental Sciences SC Environmental Sciences & Ecology GA DU5RM UT WOS:000382269000008 PM 27328400 ER PT J AU McMahen, RL Strynar, MJ McMillan, L DeRose, E Lindstrom, AB AF McMahen, Rebecca L. Strynar, Mark J. McMillan, Larry DeRose, Eugene Lindstrom, Andrew B. TI Comparison of fipronil sources in North Carolina surface water and identification of a novel fipronil transformation product in recycled wastewater SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Fipronil; Source evaluation; Wastewater; Transformation; High resolution mass spectrometry; Water reuse ID ENVIRONMENTAL FATE; TOXICITY; INSECTICIDE; PESTICIDES; MECHANISMS; CHLORINE; EXPOSURE; STREAMS; INDOOR AB Fipronil is a phenylpyrazole insecticide that is widely used in residential and agricultural settings to control ants, roaches, termites, and other pests. Fipronil and its transformation products have been found in a variety of environmental matrices, but the source[s] which makes the greatest contribution to fipronil in surface water has yet to be determined. A sampling effort designed to prioritize known fipronil inputs (golf courses, residential areas, biosolids application sites and wastewater facilities) was conducted in North Carolina to learn more about the origins of fipronil in surface water. High resolution mass spectrometry (HRMS) analysis indicated that fipronil and its known derivatives were routinely present in all samples, but concentrations were substantially elevated near wastewater treatment plant outfalls (range 10-500 ng/L combined), suggesting that they predominate as environmental sources. Corresponding recycled wastewater samples, which were treated with NaOCl for disinfection, showed disappearance of fipronil and all known degradates. HRMS and nuclear magnetic resonance (NMR) analysis techniques were used to determine that all fipronil-related compounds are oxidized to a previously unidentified fipronil sulfone chloramine species in recycled wastewater. The implications of the presence of a new fipronil-related compound in recycled wastewater need to be considered. Published by Elsevier B.V. C1 [McMahen, Rebecca L.; Strynar, Mark J.; Lindstrom, Andrew B.] US EPA, Natl Exposure Res Lab, 109 TW Alexander Dr, Durham, NC 27705 USA. [McMillan, Larry] US EPA, Natl Caucus & Ctr Black Aged Employee, Natl Exposure Res Lab, 109 TW Alexander Dr, Durham, NC 27705 USA. [DeRose, Eugene] NIEHS, Nucl Magnet Resonance Facil, 111 TW Alexander Dr, Durham, NC 27713 USA. RP Strynar, MJ (reprint author), US EPA, Natl Exposure Res Lab, 109 TW Alexander Dr, Durham, NC 27705 USA. EM strynar.mark@epa.gov NR 26 TC 1 Z9 1 U1 15 U2 16 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD NOV 1 PY 2016 VL 569 BP 880 EP 887 DI 10.1016/j.scitotenv.2016.05.085 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA DU5RM UT WOS:000382269000086 PM 27378152 ER PT J AU Evenson, GR Golden, HE Lane, CR D'Amico, E AF Evenson, Grey R. Golden, Heather E. Lane, Charles R. D'Amico, Ellen TI An improved representation of geographically isolated wetlands in a watershed-scale hydrologic model SO HYDROLOGICAL PROCESSES LA English DT Article DE connectivity; fill-spill hydrology; GIW; hydrology; Soil and Water Assessment Tool (SWAT) ID UNITED-STATES; NORTH-DAKOTA; SWAT MODEL; PRAIRIE; STORAGE; QUANTIFICATION; CONNECTIVITY; SIMULATIONS; UNCERTAINTY; CALIBRATION AB Geographically isolated wetlands (GIWs), defined as wetlands surrounded by uplands, provide an array of ecosystem goods and services. Within the United States, federal regulatory protections for GIWs are contingent, in part, on the quantification of their singular or aggregate effects on the hydrological, biological, or chemical integrity of waterways regulated by the Clean Water Act (CWA). However, limited tools are available to assess the downgradient effects of GIWs. We constructed a Soil and Water Assessment Tool (SWAT) model with improved representations of GIW hydrologic processes for the approximately 1700 km(2) Pipestem Creek watershed in the Prairie Pothole Region of North Dakota, USA. We then executed a series of novel modifications on the Pipestem Creek SWAT model. We (1) redefined the model's hydrologic response unit spatial boundaries to conform to mapped GIWs and associated watershed boundaries, (2) constructed a series of new model input files to direct the simulation of GIW fill-spill hydrology and upland flows to GIWs, and (3) modified the model source code to facilitate use of the new SWAT input files and improve GIW water balance simulations. We then calibrated and verified our modified SWAT model at a daily time step from 2009 through 2013. Simulation results indicated good predictive power (the maximum Nash-Sutcliffe Efficiency statistic was 0.86) and an acceptable range of uncertainty (measured using the Sequential Uncertainty Fitting v.2 uncertainty statistics). Simulation results additionally indicated good model performance with respect to GIW water balance simulations based on literature-based descriptions of regional GIW hydrologic behaviour. Our modified SWAT model represents a critical step in advancing scientific understandings of the watershed-scale hydrologic effects of GIWs and provides a novel method for future assessments in different watersheds and physiographic regions. Copyright (C) 2016 John Wiley & Sons, Ltd. C1 [Evenson, Grey R.] US EPA, Oak Ridge Inst Sci & Educ, Off Res & Dev, Natl Exposure Res Lab, 26 W Martin Luther King Dr,MS-592, Cincinnati, OH 45268 USA. [Golden, Heather E.; Lane, Charles R.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Cincinnati, OH USA. [D'Amico, Ellen] CSS Dynamac Corp, Cincinnati, OH USA. RP Evenson, GR (reprint author), US EPA, Oak Ridge Inst Sci & Educ, Off Res & Dev, Natl Exposure Res Lab, 26 W Martin Luther King Dr,MS-592, Cincinnati, OH 45268 USA. EM evenson.grey@epa.gov NR 59 TC 0 Z9 0 U1 8 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0885-6087 EI 1099-1085 J9 HYDROL PROCESS JI Hydrol. Process. PD OCT 30 PY 2016 VL 30 IS 22 BP 4168 EP 4184 DI 10.1002/hyp.10930 PG 17 WC Water Resources SC Water Resources GA EC6VQ UT WOS:000388275200013 ER PT J AU Sullivan, RC Crippa, P Hallar, AG Clarisse, L Whitburn, S Van Damme, M Leaitch, WR Walker, JT Khlystov, A Pryor, SC AF Sullivan, R. C. Crippa, P. Hallar, A. G. Clarisse, L. Whitburn, S. Van Damme, M. Leaitch, W. R. Walker, J. T. Khlystov, A. Pryor, S. C. TI Using satellite-based measurements to explore spatiotemporal scales and variability of drivers of new particle formation SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article DE new particle formation; satellite remote sensing; aerosol particles; spatiotemporal variability; nucleation; trace gases ID EASTERN NORTH-AMERICA; ATMOSPHERIC AEROSOL NUCLEATION; CLOUD CONDENSATION NUCLEI; SULFURIC-ACID; SIZE-DISTRIBUTION; FORMATION EVENTS; MODE PARTICLES; ORGANIC VAPORS; UNITED-STATES; GROWTH AB New particle formation (NPF) can potentially alter regional climate by increasing aerosol particle (hereafter particle) number concentrations and ultimately cloud condensation nuclei. The large scales on which NPF is manifest indicate potential to use satellite-based (inherently spatially averaged) measurements of atmospheric conditions to diagnose the occurrence of NPF and NPF characteristics. We demonstrate the potential for using satellite-based measurements of insolation (UV), trace gas concentrations (sulfur dioxide (SO2), nitrogen dioxide (NO2), ammonia (NH3), formaldehyde (HCHO), and ozone (O-3)), aerosol optical properties (aerosol optical depth (AOD) and angstrom ngstrom exponent (AE)), and a proxy of biogenic volatile organic compound emissions (leaf area index (LAI) and temperature (T)) as predictors for NPF characteristics: formation rates, growth rates, survival probabilities, and ultrafine particle (UFP) concentrations at five locations across North America. NPF at all sites is most frequent in spring, exhibits a one-day autocorrelation, and is associated with low condensational sink (AODxAE) and HCHO concentrations, and high UV. However, there are important site-to-site variations in NPF frequency and characteristics, and in which of the predictor variables (particularly gas concentrations) significantly contribute to the explanatory power of regression models built to predict those characteristics. This finding may provide a partial explanation for the reported spatial variability in skill of simple generalized nucleation schemes in reproducing observed NPF. In contrast to more simple proxies developed in prior studies (e.g., based on AOD, AE, SO2, and UV), use of additional predictors (NO2, NH3, HCHO, LAI, T, and O-3) increases the explained temporal variance of UFP concentrations at all sites. C1 [Sullivan, R. C.; Pryor, S. C.] Cornell Univ, Dept Earth & Atmospher Sci, Ithaca, NY 14850 USA. [Crippa, P.] Newcastle Univ, Sch Civil Engn & Geosci, COMET, Newcastle Upon Tyne, Tyne & Wear, England. [Hallar, A. G.] Desert Res Inst, Storm Peak Lab, Steamboat Springs, CO USA. [Hallar, A. G.] Univ Utah, Dept Atmospher Sci, Salt Lake City, UT USA. [Clarisse, L.; Whitburn, S.; Van Damme, M.] Univ Libre Bruxelles, Serv Chim Quant & Photophys, Spect Atmosphere, Brussels, Belgium. [Leaitch, W. R.] Environm Canada, Toronto, ON, Canada. [Walker, J. T.] US EPA, Natl Risk Management Res Lab, Off Res & Dev, Durham, NC USA. [Khlystov, A.] Desert Res Inst, Reno, NV USA. [Pryor, S. C.] Indiana Univ, Pervas Technol Inst, Bloomington, IN USA. RP Sullivan, RC (reprint author), Cornell Univ, Dept Earth & Atmospher Sci, Ithaca, NY 14850 USA. EM rcs365@cornell.edu FU NASA Earth and Space Science Fellowship Program [14-EARTH14F-0207]; L'Oreal-UNESCO UK and Ireland Fellowship For Women In Science; Belgian F.R.S-FNRS; Boursier FRIA; NSF [1102309, 1517365]; NASA [NNX16AG31G] FX Funding was supplied by the NASA Earth and Space Science Fellowship Program Grant "14-EARTH14F-0207" (R.C.S.), L'Oreal-UNESCO UK and Ireland Fellowship For Women In Science (P.C.), Belgian F.R.S-FNRS (L.C.), Boursier FRIA (S.W.), NSF (1102309 and 1517365), and NASA (NNX16AG31G) (S.C.P.). We also gratefully acknowledge computational resources provided by the Lilly Endowment, Inc. to the Indiana University Pervasive Technology Institute and the Indiana METACyt Initiative. The MODIS and OMI satellite data were collected under the NASA Earth-Sun System Division and Science Mission Directorate, SGP PSD data were acquired under the DoE Atmospheric Radiation Measurement Program. SPL is a permittee of the Medicine-Bow Routt National Forests, and we acknowledge assistance from Randolph Borys and Ian McCubbin. The views expressed in this article are those of the author(s) and do not necessarily represent the views or policies of the U.S. Environmental Protection Agency. Data are available from: MODIS and OMI satellite data (NASA, http://reverb.echo.nasa.gov/reverb), IASA NH3 (L. Clarisse, lclariss@ulb.ac.be), PSD from Duke (J. T. Walker, Walker. Johnt@epa.gov), Egbert (W. R. Leaitch, richard.leaitch@canada.ca), SGP (U.S. DoE, http://www.archive.arm.gov/), SPL (A. G. Hallar, gannet.hallar@dri.edu), and MMSF (S. C. Pryor, sp2279@cornell.edu). NR 86 TC 1 Z9 1 U1 13 U2 13 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X EI 2169-8996 J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD OCT 27 PY 2016 VL 121 IS 20 BP 12217 EP 12235 DI 10.1002/2016JD025568 PG 19 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA EC7CJ UT WOS:000388293100011 ER PT J AU Wigand, C Sundberg, K Hanson, A Davey, E Johnson, R Watson, E Morris, J AF Wigand, C. Sundberg, K. Hanson, A. Davey, E. Johnson, R. Watson, E. Morris, J. TI Varying Inundation Regimes Differentially Affect Natural and Sand-Amended Marsh Sediments SO PLoS One LA English DT Article ID SEA-LEVEL RISE; COASTAL SALT-MARSH; TIDAL MARSH; SPARTINA-ALTERNIFLORA; VEGETATION CHANGE; DREDGED MATERIAL; NORTH-CAROLINA; BRACKISH MARSH; NEW-ENGLAND; SOIL AB Climate change is altering sea level rise rates and precipitation patterns worldwide. Coastal wetlands are vulnerable to these changes. System responses to stressors are important for resource managers and environmental stewards to understand in order to best manage them. Thin layer sand or sediment application to drowning and eroding marshes is one approach to build elevation and resilience. The above-and below-ground structure, soil carbon dioxide emissions, and pore water constituents in vegetated natural marsh sediments and sand-amended sediments were examined at varying inundation regimes between mean sea level and mean high water (0.82 m NAVD88 to 1.49 m NAVD88) in a field experiment at Laws Point, part of the Plum Island Sound Estuary (MA). Significantly lower salinities, pH, sulfides, phosphates, and ammonium were measured in the sand-amended sediments than in the natural sediments. In natural sediments there was a pattern of increasing salinity with increasing elevation while in the sand-amended sediments the trend was reversed, showing decreasing salinity with increasing elevation. Sulfide concentrations generally increased from low to high inundation with highest concentrations at the highest inundation (i. e., at the lowest elevations). High pore water phosphate concentrations were measured at low elevations in the natural sediments, but the sand-amended treatments had mostly low concentrations of phosphate and no consistent pattern with elevation. At the end of the experiment the lowest elevations generally had the highest measures of pore water ammonium. Soil carbon dioxide emissions were greatest in the sandamended mesocosms and at higher elevations. Differences in coarse root and rhizome abundances and volumes among the sediment treatments were detected with CT imaging, but by 20 weeks the natural and sand-amended treatments showed similar total belowground biomass at the intermediate and high elevations. Although differences in pore water nutrient concentrations, pH, salinity, and belowground root and rhizome morphology were detected between the natural and sand-amended sediments, similar belowground productivity and total biomass were measured by the end of the growing season. Since the belowground productivity supports organic matter accumulation and peat buildup in marshes, our results suggest that thin layer sand or sediment application is a viable climate adaptation action to build elevation and coastal resiliency, especially in areas with low natural sediment supplies. C1 [Wigand, C.; Hanson, A.; Davey, E.; Johnson, R.; Watson, E.] US EPA, Atlantic Ecol Div, ORD NHEERL, Narragansett, RI USA. [Sundberg, K.; Morris, J.] Univ South Carolina, Belle W Baruch Inst Marine & Coastal Sci, Columbia, SC USA. [Sundberg, K.; Morris, J.] Univ South Carolina, Dept Biol Sci, Columbia, SC USA. [Watson, E.] Drexel Univ, Acad Nat Sci, Biodivers Earth & Environm Sci Dept, Philadelphia, PA 19104 USA. RP Wigand, C (reprint author), US EPA, Atlantic Ecol Div, ORD NHEERL, Narragansett, RI USA. EM wigand.cathleen@epa.gov FU NSF [OCE 1058747, OCE 123821] FX This work was supported by NSF #OCE 1058747 and #OCE 123821 (J. Morris); The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 63 TC 0 Z9 0 U1 11 U2 11 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD OCT 27 PY 2016 VL 11 IS 10 DI 10.1371/journal.pone.0164956 PG 24 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EE4VY UT WOS:000389604900036 ER PT J AU O'Donnell, AJ Lytle, DA Harmon, S Vu, K Chait, H Dionysiou, DD AF O'Donnell, Alissa J. Lytle, Darren A. Harmon, Stephen Vu, Kevin Chait, Hannah Dionysiou, Dionysios D. TI Removal of strontium from drinking water by conventional treatment and lime softening in bench-scale studies SO WATER RESEARCH LA English DT Article DE Strontium; Drinking water; Coagulation; Lime softening; Jar test ID AQUEOUS-SOLUTIONS; ADSORPTION; PRECIPITATION; PARTICLES; CARBONATE; VATERITE; BEHAVIOR; SORPTION; ACID; SR2+ AB The United States Environmental Protection Agency Contaminant Candidate List 3 lists strontium as a contaminant for potential regulatory consideration in drinking water. Very limited data is available on strontium removal from drinking water and as a result, there is an immediate need for treatment information. The objective of this work is to evaluate the effectiveness of coagulation/filtration and lime soda ash softening treatment methods to remove strontium from surface and ground waters. Coagulation/filtration jar test results on natural waters showed that conventional treatment with aluminum and iron coagulants were able to achieve only 12% and 5.9% strontium removal, while lime softening removed as high as 78% from natural strontium-containing ground water. Controlled batch experiments on synthetic water showed that strontium removal during the lime-soda ash softening was affected by pH, calcium concentration and dissolved inorganic carbon concentration. In all softening jar tests, the final strontium concentration was directly related to the initial strontium concentration and the removal of strontium was directly associated with calcium removal. Precipitated solids showed well-formed crystals or agglomerates of mixed solids, two polymorphs of calcium carbonate (vaterite and calcite), and strontianite, depending on initial water quality conditions. X-ray diffraction analysis suggested that strontium was likely incorporated in the calcium carbonate crystal lattice and was likely responsible for removal during lime softening. (C) 2016 Published by Elsevier Ltd. C1 [O'Donnell, Alissa J.; Dionysiou, Dionysios D.] Univ Cincinnati, Dept Biomed Chem & Environm Engn, 601 Engn Res Ctr, Cincinnati, OH 45221 USA. [Lytle, Darren A.; Harmon, Stephen] US EPA, ORD, NRMRL, WSWRD, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. [Vu, Kevin] Macaulay Honors Coll City Coll New York, Dept Civil Engn, 160 Convent Ave, New York, NY 10031 USA. [Chait, Hannah] Univ Illinois, Dept Chem & Biomol Engn, 600 S Matthews Ave, Urbana, IL 61801 USA. RP Lytle, DA (reprint author), US EPA, ORD, NRMRL, WSWRD, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM lytle.darren@epa.gov NR 36 TC 0 Z9 0 U1 22 U2 22 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0043-1354 J9 WATER RES JI Water Res. PD OCT 15 PY 2016 VL 103 BP 319 EP 333 DI 10.1016/j.watres.2016.06.036 PG 15 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA DV9WE UT WOS:000383292100035 PM 27475121 ER PT J AU Domagalski, J Majewski, MS Alpers, CN Eckley, CS Eagles-Smith, CA Schenk, L Wherry, S AF Domagalski, Joseph Majewski, Michael S. Alpers, Charles N. Eckley, Chris S. Eagles-Smith, Collin A. Schenk, Liam Wherry, Susan TI Comparison of mercury mass loading in streams to atmospheric deposition in watersheds of Western North America: Evidence for non-atmospheric mercury sources SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Western North American Mercury Synthesis WNAMS; Urban contaminants; Stream loads; historical mining ID DRY DEPOSITION; TRANSPORT; RIVER; CONTAMINATION; CALIFORNIA; DATABASES; BUDGETS; CLIMATE; EASTERN; NEVADA AB Annual stream loads of mercury (Hg) and inputs of wet and dry atmospheric Hg deposition to the landscape were investigated in watersheds of the Western United States and the Canadian-Alaskan Arctic. Mercury concentration and discharge data from flow gauging stations were used to compute annual mass loads with regression models. Measured wet and modeled dry deposition were compared to annual stream loads to compute ratios of Hg stream load to total Hg atmospheric deposition. Watershed land uses or cover included mining, undeveloped, urbanized, and mixed. Of 27 watersheds that were investigated, 15 had some degree of mining, either of Hg or precious metals (gold or silver), where Hg was used in the amalgamation process. Stream loads in excess of annual Hg atmospheric deposition (ratio > 1) were observed in watersheds containing Hg mines and in relatively small and medium-sized watersheds with gold or silver mines, however, larger watersheds containing gold or silver mines, some of which also contain large dams that trap sediment, were sometimes associated with lower load ratios (<0.2). In the non-Arctic regions, watersheds with natural vegetation tended to have low ratios of stream load to Hg deposition (<0.1), whereas urbanized areas had higher ratios (0.34-1.0) because of impervious surfaces. This indicated that, in ecosystems with natural vegetation, Hg is retained in the soil and may be transported subsequently to streams as a result of erosion or in association with dissolved organic carbon. Arctic watersheds (Mackenzie and Yukon Rivers) had a relatively elevated ratio of streamload to atmospheric deposition (0.27 and 0.74), possibly because of melting glaciers or permafrost releasing previously stored Hg to the streams. Overall, our research highlights the important role of watershed characteristics in determining whether a landscape is a net source of Hg or a net sink of atmospheric Hg. Published by Elsevier B.V. C1 [Domagalski, Joseph; Majewski, Michael S.; Alpers, Charles N.] US Geol Survey, Calif Water Sci Ctr, 6000 J St,Placer Hall, Sacramento, CA 95819 USA. [Eckley, Chris S.] US EPA, Off Environm Assessment, EPA Reg 10,1200 6th Ave,Suite 900, Seattle, WA 98101 USA. [Eagles-Smith, Collin A.] US Geol Survey, Forest & Rangeland Ecosyst Sci Ctr, 3200 SW Jefferson Way, Corvallis, OR 97331 USA. [Schenk, Liam] US Geol Survey, Oregon Water Sci Ctr, 2795 Anderson Ave,Suite 106, Klamath Falls, OR 97603 USA. [Wherry, Susan] US Geol Survey, OregonWater Sci Ctr, 2130 SW 5th Ave, Portland, OR 97201 USA. RP Domagalski, J (reprint author), US Geol Survey, Calif Water Sci Ctr, 6000 J St,Placer Hall, Sacramento, CA 95819 USA. EM joed@usgs.gov OI Eagles-Smith, Collin/0000-0003-1329-5285; Alpers, Charles/0000-0001-6945-7365 FU John Wesley Powell Center for Analysis and Synthesis; U.S. Geological Survey; Region-10 U.S. Environmental Protection Agency (RARE) FX This work was conducted as a part of the Western North American Mercury Synthesis Working Group supported by the John Wesley Powell Center for Analysis and Synthesis, funded by the U.S. Geological Survey. We also acknowledge a grant from the Region-10 U.S. Environmental Protection Agency (RARE). We also gratefully acknowledge the contribution from Dr. Jerry Lin (Lamar University) for providing output from the Community Multi-scale Air-quality (CMAQ) model of 2009 Hg dry deposition. We are also grateful to the Sacramento Coordinated Monitoring Program (California) for sharing their Fig data for the Sacramento and American Rivers and the Regional Monitoring Program for Water Quality in the San Francisco Bay. We thank Carl Thodal and Eric Morway, of the Nevada Water Science Center (USGS), for sharing data on the Carson River watershed. NR 60 TC 3 Z9 3 U1 36 U2 39 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD OCT 15 PY 2016 VL 568 BP 638 EP 650 DI 10.1016/j.scitotenv.2016.02.112 PG 13 WC Environmental Sciences SC Environmental Sciences & Ecology GA DU5NK UT WOS:000382258300065 PM 27015962 ER PT J AU Eckley, CS Tate, MT Lin, CJ Gustin, M Dent, S Eagles-Smith, C Lutz, MA Wickland, KP Wang, B Gray, JE Edwards, GC Krabbenhoft, DP Smith, DB AF Eckley, Chris S. Tate, Mike T. Lin, Che-Jen Gustin, Mae Dent, Stephen Eagles-Smith, Collin Lutz, Michelle A. Wickland, Kimberly P. Wang, Bronwen Gray, John E. Edwards, Grant C. Krabbenhoft, Dave P. Smith, David B. TI Surface-airmercury fluxes across Western North America: A synthesis of spatial trends and controlling variables SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Mercury; Dynamic flux chamber; Emission; Deposition; Western North America ID GASEOUS ELEMENTAL MERCURY; TERRESTRIAL BACKGROUND SURFACES; NORTHEASTERN UNITED-STATES; ATMOSPHERIC MERCURY; AIR/SURFACE EXCHANGE; SOIL MERCURY; EASTERN USA; GOLD-MINES; CHAMBER MEASUREMENT; CONCEPTUAL-MODEL AB Mercury (Hg) emission and deposition can occur to and from soils, and are an important component of the global atmospheric Hg budget. This paper focuses on synthesizing existing surface-air Hg flux data collected throughout the Western North American region and is part of a series of geographically focused Hg synthesis projects. A database of existing Hg flux data collected using the dynamic flux chamber (DFC) approach from almost a thousand locations was created for the Western North America region. Statistical analysis was performed on the data to identify the important variables controlling Hg fluxes and to allow spatiotemporal scaling. The results indicated that most of the variability in soil-air Hg fluxes could be explained by variations in soil-Hg concentrations, solar radiation, and soil moisture. This analysis also identified that variations in DFC methodological approaches were detectable among the field studies, with the chamber material and sampling flushing flow rate influencing the magnitude of calculated emissions. The spatiotemporal scaling of soil-air Hg fluxes identified that the largest emissions occurred from irrigated agricultural landscapes in California. Vegetation was shown to have a large impact on surface-air Hg fluxes due to both a reduction in solar radiation reaching the soil as well as from direct uptake of Hg in foliage. Despite high soil Hg emissions from some forested and other heavily vegetated regions, the net ecosystem flux (soil flux + vegetation uptake) was low. Conversely, sparsely vegetated regions showed larger net ecosystem emissions, which were similar in magnitude to atmospheric Hg deposition (except for the Mediterranean California region where soil emissions were higher). The net ecosystem flux results highlight the important role of landscape characteristics in effecting the balance between Hg sequestration and (re-)emission to the atmosphere. Published by Elsevier B.V. C1 [Eckley, Chris S.] US Environm Protect Agcy, Reg 10, Seattle, WA 98101 USA. [Tate, Mike T.; Lutz, Michelle A.; Krabbenhoft, Dave P.] US Geol Survey, Middleton, WI 53562 USA. [Lin, Che-Jen] Lamar Univ, Ctr Adv Water & Air Qual, Beaumont, TX 77710 USA. [Gustin, Mae] Univ Nevada, Dept Nat Resources & Environm Sci, Reno, NV 89557 USA. [Dent, Stephen] CDM Smith, Portland, OR 97205 USA. [Eagles-Smith, Collin] US Geol Survey, Corvallis, OR 97331 USA. [Wickland, Kimberly P.] US Geol Survey, Boulder, CO 80303 USA. [Wang, Bronwen] US Geol Survey, Anchorage, AK 99508 USA. [Gray, John E.; Smith, David B.] US Geol Survey, Box 25046, Denver, CO 80225 USA. [Edwards, Grant C.] Macquarie Univ, Dept Geog & Environm, N Ryde, NSW 2109, Australia. RP Eckley, CS (reprint author), US Environm Protect Agcy, Reg 10, Seattle, WA 98101 USA. EM eckley.chris@epa.gov RI Lin, Che-Jen/K-1808-2013; OI Lin, Che-Jen/0000-0001-5990-3093; Wickland, Kimberly/0000-0002-6400-0590 FU John Wesley Powell Center for Analysis and Synthesis; U.S. Geological Survey; Region-10 US EPA Regional Applied Research Effort (RARE) grant [14RARE10P18]; ORD Principal Investigator Heather Golden (Ecological Exposure Research Division, National Exposure Research Laboratory); Regional Science Liaison Bruce Duncan FX This work was conducted as part of the Western North American Mercury Synthesis Group supported by the John Wesley Powell Center for Analysis and Synthesis, funded by the U.S. Geological Survey. We are very thankful for funding provided by the Region-10 US EPA Regional Applied Research Effort (RARE) grant (14RARE10P18); and our ORD Principal Investigator Heather Golden (Ecological Exposure Research Division, National Exposure Research Laboratory), and Regional Science Liaison Bruce Duncan. We are also grateful for the Hg flux data provided for this project by Mark Engle (USGS) and Daniel Obrist (Desert Research Institute) and the GIS assistance by Alex Hall (Dynamac Corporation, contractor to the US EPA). We thank the EPA internal reviewers Lorraine Edmond and Joe Goulet and the journal's anonymous reviewers for their time and input on improving the manuscript. This research does not reflect the official positions and policies of the US EPA. This manuscript has been peer reviewed and approved for publication consistent with USGS Fundamental Science Practices (http://pubs.usgs.govlcirc/1367/). Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U.S. Government. NR 98 TC 3 Z9 3 U1 12 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD OCT 15 PY 2016 VL 568 BP 651 EP 665 DI 10.1016/j.scitotenv.2016.02.121 PG 15 WC Environmental Sciences SC Environmental Sciences & Ecology GA DU5NK UT WOS:000382258300066 PM 26936663 ER PT J AU Fleck, JA Marvin-DiPasquale, M Eagles-Smith, CA Ackerman, JT Lutz, MA Tate, M Alpers, CN Hall, BD Krabbenhoft, DP Eckley, CS AF Fleck, Jacob A. Marvin-DiPasquale, Mark Eagles-Smith, Collin A. Ackerman, Joshua T. Lutz, Michelle A. Tate, Michael Alpers, Charles N. Hall, Britt D. Krabbenhoft, David P. Eckley, Chris S. TI Mercury and methylmercury in aquatic sediment across western North America SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Spatial mercury patterns; Western North American Mercury Synthesis WNAMS; Mercury methylation; Aquatic sediment ID SAN-FRANCISCO BAY; METHYL MERCURY; QUALITY GUIDELINES; WATER; TRACE; LAKES; FISH; USA; CONTAMINATION; SPECIATION AB Large-scale assessments are valuable in identifying primary factors controlling total mercury (THg) and monomethyl mercury (MeHg) concentrations, and distribution in aquatic ecosystems. Bed sediment THg and MeHg concentrations were compiled for >16,000 samples collected from aquatic habitats throughout the West between 1965 and 2013. The influence of aquatic feature type (canals, estuaries, lakes, and streams), and environmental setting (agriculture, forest, open-water, range, wetland, and urban) on THg and MeHg concentrations was examined. THg concentrations were highest in lake (29.3 +/- 6.5 mu g kg(-1)) and canal (28.6 +/- 6.9 mu g kg(-1)) sites, and lowest in stream(20.7 +/- 4.6 mu g kg(-1)) and estuarine (23.6 +/- 5.6 mu g kg(-1)) sites, which was partially a result of differences in grain size related to hydrologic gradients. By environmental setting, open-water (36.8 +/- 2.2 mu g kg(-1)) and forested (32.0 +/- 2.7 mu g kg(-1)) sites generally had the highest THg concentrations, followed by wetland sites (28.9 +/- 1.7 mu g kg(-1)), rangeland (25.5 +/- 1.5 mu g kg(-1)), agriculture (23.4 +/- 2.0 mu g kg(-1)), and urban (22.7 +/- 2.1 mu g kg(-1)) sites. MeHg concentrations also were highest in lakes (0.55 +/- 0.05 mu g kg(-1)) and canals (0.54 +/- 0.11 mu g kg(-1)), but, in contrast to THg, MeHg concentrations were lowest in open-water sites (0.22 +/- 0.03 mu g kg(-1)). The median percent MeHg (relative to THg) for the western region was 0.7%, indicating an overall low methylation efficiency; however, a significant subset of data (n > 100) had percentages that represent elevated methylation efficiency (>6%). MeHg concentrations were weakly correlated with THg (r(2) = 0.25) across western North America. Overall, these results highlight the large spatial variability in sediment THg and MeHg concentrations throughout western North America and underscore the important roles that landscape and land-use characteristics have on the MeHg cycle. Published by Elsevier B.V. C1 [Fleck, Jacob A.; Alpers, Charles N.] US Geol Survey, Calif Water Sci Ctr, 6000 J St,Placer Hall, Sacramento, CA 95819 USA. [Marvin-DiPasquale, Mark] US Geol Survey, 345 Middlefield Rd, Menlo Pk, CA 94025 USA. [Eagles-Smith, Collin A.] US Geol Survey, Forest & Rangeland Ecosyst Sci Ctr, Corvallis, OR USA. [Ackerman, Joshua T.] US Geol Survey, Western Ecol Res Ctr, Dixon Field Stn, 800 Business Pk Dr,Suite D, Dixon, CA 95620 USA. [Lutz, Michelle A.; Tate, Michael; Krabbenhoft, David P.] US Geol Survey, 8505 Res Way, Middleton, WI 53562 USA. [Hall, Britt D.] Univ Regina, Dept Biol, 3737 Wascana Pkwy, Regina, SK S4S 0A2, Canada. [Eckley, Chris S.] US EPA, 1200 6th Ave,St 900,OEA 095, Seattle, WA 98101 USA. RP Fleck, JA (reprint author), US Geol Survey, Calif Water Sci Ctr, 6000 J St,Placer Hall, Sacramento, CA 95819 USA. EM jafleck@usgs.gov OI Alpers, Charles/0000-0001-6945-7365 FU John Wesley Powell Center for Analysis and Synthesis, a joint venture of the US Geological Survey; National Science Foundation; USGS Contaminant Biology Program; US EPA Region 10 through a Regional Applied Research Effort (RARE) grant; Regional Science Liaison Bruce Duncan; US Geological Survey California Water Science Center FX This work was conducted as a part of the Western North American Mercury Synthesis Working Group supported by the John Wesley Powell Center for Analysis and Synthesis, a joint venture of the US Geological Survey and the National Science Foundation. We are thankful for additional support provided by the USGS Contaminant Biology Program. Additional funding for geospatial analysis was provided US EPA Region 10 through a Regional Applied Research Effort (RARE) grant managed by ORD Principal Investigator Heather Golden (Ecological Exposure Research Division, National Exposure Research Laboratory) and Regional Science Liaison Bruce Duncan. We thank US Geological Survey California Water Science Center colleagues Roger Fujii and Paul Work for general support and Mike Solt and Jim Orlando for technical assistance. The authors would also like to extend our appreciation to working group team members including Kiira Siitari, Joe Domagalski, George Aiken, Daniel Obrist, and Madeleine Turnquist. We would like to extend special thanks to Jim Wiener and David Evers for their leadership in the Mercury Synthesis series. Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the US Government. NR 56 TC 2 Z9 2 U1 39 U2 42 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD OCT 15 PY 2016 VL 568 BP 727 EP 738 DI 10.1016/j.scitotenv.2016.03.044 PG 12 WC Environmental Sciences SC Environmental Sciences & Ecology GA DU5NK UT WOS:000382258300073 PM 27130329 ER PT J AU Eagles-Smith, CA Wiener, JG Eckley, CS Willacker, JJ Evers, DC Marvin-DiPasquale, M Obrist, D Fleck, JA Aiken, GR Lepak, JM Jackson, AK Webster, JP Stewart, AR Davis, JA Alpers, CN Ackerman, JT AF Eagles-Smith, Collin A. Wiener, James G. Eckley, Chris S. Willacker, James J. Evers, David C. Marvin-DiPasquale, Mark Obrist, Daniel Fleck, Jacob A. Aiken, George R. Lepak, Jesse M. Jackson, Allyson K. Webster, Jackson P. Stewart, A. Robin Davis, Jay A. Alpers, Charles N. Ackerman, Joshua T. TI Mercury in western North America: A synthesis of environmental contamination, fluxes, bioaccumulation, and risk to fish and wildlife SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Legacy mining; Atmospheric deposition; Birds; Bioaccumulation; Landscape; Methylmercury exposure; Risk; Bigeochemistry ID SAN-FRANCISCO BAY; NORTHEASTERN UNITED-STATES; GREAT-LAKES REGION; ATMOSPHERIC MERCURY; FRESH-WATER; METHYLMERCURY PRODUCTION; METHYL-MERCURY; AQUATIC ENVIRONMENT; PISCIVOROUS FISH; CLIMATE-CHANGE AB Western North America is a region defined by extreme gradients in geomorphology and climate, which support a diverse array of ecological communities and natural resources. The region also has extreme gradients in mercury (Hg) contamination due to a broad distribution of inorganic Hg sources. These diverse Hg sources and a varied landscape create a unique and complex mosaic of ecological risk from Hg impairment associated with differential methylmercury (MeHg) production and bioaccumulation. Understanding the landscape-scale variation in the magnitude and relative importance of processes associated with Hg transport, methylation, and MeHg bioaccumulation requires a multidisciplinary synthesis that transcends small-scale variability. The Western North America Mercury Synthesis compiled, analyzed, and interpreted spatial and temporal patterns and drivers of Hg and MeHg in air, soil, vegetation, sediments, fish, and wildlife across western North America. This collaboration evaluated the potential risk from Hg to fish, and wildlife health, human exposure, and examined resource management activities that influenced the risk of Hg contamination. This paper integrates the key information presented across the individual papers that comprise the synthesis. The compiled information indicates that Hg contamination is widespread, but heterogeneous, across western North America. The storage and transport of inorganic Hg across landscape gradients are largely regulated by climate and land-cover factors such as plant productivity and precipitation. Importantly, there was a striking lack of concordance between pools and sources of inorganic Hg, and MeHg in aquatic food webs. Additionally, water management had a widespread influence on MeHg bioaccumulation in aquatic ecosystems, whereas mining impacts where relatively localized. These results highlight the decoupling of inorganic Hg sources with MeHg production and bioaccumulation. Together the findings indicate that developing efforts to control MeHg production in the West may be particularly beneficial for reducing food web exposure instead of efforts to simply control inorganic Hg sources. Published by Elsevier B.V. C1 [Eagles-Smith, Collin A.; Willacker, James J.] US Geol Survey, Forest & Rangeland Ecosyst Sci Ctr, 3200 SW Jefferson Way, Corvallis, OR 97331 USA. [Wiener, James G.] Univ Wisconsin, River Studies Ctr, 1725 State St, La Crosse, WI 54601 USA. [Eckley, Chris S.] US EPA, Reg 10,2100 6th Ave,Suite 900, Seattle, WA 98101 USA. [Evers, David C.] Biodivers Res Inst, 276 Canco Rd, Portland, ME 04103 USA. [Marvin-DiPasquale, Mark; Stewart, A. Robin] US Geol Survey, 345 Middlefield Rd, Menlo Pk, CA 94025 USA. [Obrist, Daniel] Desert Res Inst, Div Atmospher Sci, 2215 Raggio Pkwy, Reno, NV 89512 USA. [Fleck, Jacob A.; Alpers, Charles N.] US Geol Survey, Calif Water Sci Ctr, 6000 J St,Placer Hall, Sacramento, CA 95819 USA. [Aiken, George R.] US Geol Survey, Natl Res Program, 3215 Marine St, Boulder, CO 80303 USA. [Lepak, Jesse M.] Colorado Pk & Wildlife, 317 West Prospect Rd, Ft Collins, CO 80526 USA. [Jackson, Allyson K.] Oregon State Univ, Dept Fisheries & Wildlife, 104 Nash Hall, Corvallis, OR 97331 USA. [Webster, Jackson P.] Univ Colorado, Civil Environm & Architectural Engn, Boulder, CO 80309 USA. [Davis, Jay A.] San Francisco Estuary Inst, 4911 Cent Ave, Richmond, CA 94804 USA. [Ackerman, Joshua T.] US Geol Survey, Western Ecol Res Ctr, Dixon Field Stn, 800 Business Pk Dr, Dixon, CA 95620 USA. RP Eagles-Smith, CA (reprint author), US Geol Survey, Forest & Rangeland Ecosyst Sci Ctr, 3200 SW Jefferson Way, Corvallis, OR 97331 USA. EM ceagles-smith@usgs.gov OI Marvin-DiPasquale, Mark/0000-0002-8186-9167; Willacker, James/0000-0002-6286-5224 FU John Wesley Powell Center for Analysis and Synthesis; U.S. Geological Survey; U.S. Geological Survey Contaminant Biology Program; National Park Service Air Resources Division; US EPA Region 10 RARE Program FX This work was conducted as part of the Western North America Mercury Synthesis working group supported by the John Wesley Powell Center for Analysis and Synthesis, funded by the U.S. Geological Survey, with additional support from the U.S. Geological Survey Contaminant Biology Program, National Park Service Air Resources Division, and US EPA Region 10 RARE Program. We are thankful to all the participants of the Powell Center workshops for their intellectual support, and to the countless members of the research community that expressed an interest and contributed to this effort. We are also appreciative for the efforts of Mike Tate and Michelle Lutz for GIS analysis, and David Krabbenhoft and Mae Gustin for helpful reviews. Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U.S. Government. NR 156 TC 5 Z9 5 U1 73 U2 73 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD OCT 15 PY 2016 VL 568 BP 1213 EP 1226 DI 10.1016/j.scitotenv.2016.05.094 PG 14 WC Environmental Sciences SC Environmental Sciences & Ecology GA DU5NK UT WOS:000382258300122 PM 27320732 ER PT J AU Franco, SJ Koehrn, K Axelrad, D AF Franco, Sheila J. Koehrn, Kara Axelrad, Daniel TI Percentage of Children Aged 1-5 Years with Elevated Blood Lead Levels, by Race/Ethnicity - National Health and Nutrition Examination Survey, United States, 1988-1994, 1999-2006, and 2007-2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Editorial Material C1 [Franco, Sheila J.; Koehrn, Kara; Axelrad, Daniel] US EPA, Washington, DC 20460 USA. RP Franco, SJ (reprint author), US EPA, Washington, DC 20460 USA. EM sfranco@cdc.gov; koehrn.kara@epa.gov; axelrad.daniel@epa.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD OCT 7 PY 2016 VL 65 IS 39 BP 45 EP 45 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DZ6SV UT WOS:000385993100008 ER PT J AU Ankley, G Escher, BI Hartung, T Shah, I AF Ankley, Gerald Escher, Beate I. Hartung, Thomas Shah, Imran TI Pathway-Based Approaches for Environmental Monitoring and Risk Assessment SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Editorial Material C1 [Ankley, Gerald] US EPA, Midcontinent Ecol Div, Duluth, MN 55804 USA. [Ankley, Gerald] US EPA, Environm Effects Res Lab, Duluth, MN 55804 USA. [Escher, Beate I.] UFZ Helmholtz Ctr Environm Res, Cell Toxicol, D-04318 Leipzig, Germany. [Hartung, Thomas] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA. [Shah, Imran] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA. RP Escher, BI (reprint author), UFZ Helmholtz Ctr Environm Res, Cell Toxicol, D-04318 Leipzig, Germany. EM beate.escher@ufz.de RI Escher, Beate/C-7992-2009 OI Escher, Beate/0000-0002-5304-706X NR 1 TC 1 Z9 1 U1 28 U2 28 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD OCT 4 PY 2016 VL 50 IS 19 BP 10295 EP + DI 10.1021/acs.est.6b04425 PG 2 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA DY1GC UT WOS:000384841900001 PM 27696862 ER PT J AU Xia, P Zhang, XW Xie, YW Guan, M Villeneuve, DL Yu, HX AF Xia, Pu Zhang, Xiaowei Xie, Yuwei Guan, Miao Villeneuve, Daniel L. Yu, Hongxia TI Functional Toxicogenomic Assessment of Triclosan in Human HepG2 Cells Using Genome-Wide CRISPR-Cas9 Screening SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID BODY-MASS INDEX; BREAST-CANCER; GENE-EXPRESSION; UPDATE 2013; FAT MASS; EXPOSURE; STRESS; FTO; IDENTIFICATION; INTERFERENCE AB There are thousands of chemicals used by humans and detected in the environment for which limited or no toxicological data are available. Rapid and cost-effective approaches for assessing the toxicological properties of chemicals are needed. We used CRISPR-Cas9 functional genomic screening to identify the potential molecular mechanism of a widely used antimicrobial triclosan (TCS) in HepG2 cells. Resistant genes at ICSO (the concentration causing a 50% reduction in cell viability) were significantly enriched in the adherens junction pathway, MAPK signaling pathway, and PPAR signaling pathway, suggesting a potential role in the molecular mechanism of TCS-induced cytotoxicity. Evaluation of the top-ranked resistant genes, PTO (encoding an mRNA demethylase) and MAP2K3 (a MAP kinase kinase family gene), revealed that their loss conferred resistance to TCS. In contrast, sensitive genes at IC10 and IC20 were specifically enriched in pathways involved with immune responses, which was concordant with transcriptomic profiling of TCS at concentrations of 15mg/L of chloride and >0.02mg/L of bromide) and improved survival, growth, and reproduction with alternate diets provided as increased rations over time in water-only or whole-sediment toxicity tests. A total of 24 laboratories volunteered to participate in the present interlaboratory study evaluating the performance of H. azteca in 42-d studies in control sand or control sediment using the refined methods. Improved growth and reproduction of H. azteca was observed with 2 alternate diets of 1) ramped diatoms (Thalassiosira weissflogii)+ramped Tetramin or 2) yeast-cerophyll-trout chow (YCT)+ramped Tetramin, especially when compared with results from the traditional diet of 1.8mg YCT/d. Laboratories were able to meet proposed test acceptability criteria and in most cases had lower variation in growth or reproduction compared with previous interlaboratory studies using the traditional YCT diet. Laboratory success in conducting 42-d H. azteca exposures benefited from adherence to several key requirements of the detailed testing, culturing, and handling methods. Results from the present interlaboratory study are being used to help revise standard methods for conducting 10-d to 42-d water or sediment toxicity exposures with H. azteca. Environ Toxicol Chem 2016;35:2439-2447. (c) 2016 SETAC C1 [Ivey, Chris D.; Ingersoll, Chris G.; Brumbaugh, William G.] US Geol Survey, Columbia, MO 65201 USA. [Hammer, Edward J.] US EPA, Chicago, IL USA. [Mount, Dave R.; Hockett, J. Russell; Norberg-King, Teresa J.] US EPA, Duluth, MN USA. [Soucek, Dave] Illinois Nat Hist Survey, Champaign, IL 61820 USA. [Taylor, Lisa] Environm Canada, Ottawa, ON, Canada. RP Ivey, CD (reprint author), US Geol Survey, Columbia, MO 65201 USA. EM civey@usgs.gov FU Great Lakes Restoration Initiative FX Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the US government. Funding for the present study was provided in part by the Great Lakes Restoration Initiative. The USEPA has not formally reviewed the present study; the views expressed herein may not reflect the views of the USEPA. NR 17 TC 5 Z9 5 U1 2 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD OCT PY 2016 VL 35 IS 10 BP 2439 EP 2447 DI 10.1002/etc.3417 PG 9 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DY0UD UT WOS:000384810800010 ER PT J AU Mearns, AJ Reish, DJ Oshida, PS Morrison, AM Rempel-Hester, MA Arthur, C Rutherford, N Pryor, R AF Mearns, Alan J. Reish, Donald J. Oshida, Philip S. Morrison, Ann Michelle Rempel-Hester, Mary Ann Arthur, Courtney Rutherford, Nicolle Pryor, Rachel TI Effects of Pollution on Marine Organisms SO WATER ENVIRONMENT RESEARCH LA English DT Article DE Tissue residues; toxicity; bioaccumulation; biomagnification; biomarkers; sediment; quality; ecological risk assessment; endocrine disrupters; metals; nano particles; POPs; PCBs; PAHs; PBDEs; radionuclides; pharmaceuticals; personal care products; trace metals; pesticides; biomarkers; marine biocides; oil spills; dispersants; field survey methods; sewage; marine debris; entanglement; dredging; eutrophication; fishing impacts; human disturbance; noise poluution; Arctic; Antarctic; microbes; plankton; invertebrates; fish; birds; turtles; mammals; marshes; mangroves; inter-tidal ID DEEP-WATER-HORIZON; GULF-OF-MEXICO; BASS DICENTRARCHUS-LABRAX; POLYCYCLIC AROMATIC-HYDROCARBONS; DISPERSED CRUDE-OIL; TITANIUM-DIOXIDE NANOPARTICLES; MUSSEL MYTILUS-GALLOPROVINCIALIS; MICROBIAL COMMUNITY COMPOSITION; POLYBROMINATED DIPHENYL ETHERS; ENVIRONMENTAL RISK-ASSESSMENT AB This review covers selected 2015 articles on the biological effects of pollutants and human physical disturbances on marine and estuarine plants, animals, ecosystems and habitats. The review, based largely on journal articles, covers field and laboratory measurement activities (bioaccumulation of contaminants, field assessment surveys, toxicity testing and biomarkers) as well as pollution issues of current interest including endocrine disrupters, emerging contaminants, wastewater discharges, dredging and disposal, etc. Special emphasis is placed on effects of oil spills and marine debris due largely to the 2010 Deepwater Horizon oil blowout in the Gulf of Mexico. Several topical areas reviewed in the past (ballast water and ocean acidification) were dropped this year. The focus of this review is on effects, not pollutant fate and transport. There is considerable overlap across subject areas (e.g. some bioaccumulation papers may be cited in other topical categories). Please use keyword searching of the text to locate related but distributed papers. Use this review only as a guide and please consult the original papers before citing them. C1 [Mearns, Alan J.; Rutherford, Nicolle; Pryor, Rachel] NOAA, Emergency Response Div, 7600 Sand Point Way NE, Seattle, WA 98115 USA. [Reish, Donald J.] Calif State Univ Long Beach, Dept Biol Sci, Long Beach, CA 90840 USA. [Oshida, Philip S.] US EPA, Washington, DC 20460 USA. [Morrison, Ann Michelle] Exponent Inc, Sedona, AZ USA. [Rempel-Hester, Mary Ann] Aquat Toxicol Support, Bremerton, WA USA. [Arthur, Courtney] Ind Econ Inc, Cambridge, MA USA. RP Mearns, AJ (reprint author), NOAA, Emergency Response Div, 7600 Sand Point Way NE, Seattle, WA 98115 USA. EM alan.mearns@noaa.gov NR 440 TC 0 Z9 0 U1 34 U2 36 PU WATER ENVIRONMENT FEDERATION PI ALEXANDRIA PA 601 WYTHE ST, ALEXANDRIA, VA 22314-1994 USA SN 1061-4303 EI 1554-7531 J9 WATER ENVIRON RES JI Water Environ. Res. PD OCT 1 PY 2016 VL 88 IS 10 BP 1693 EP 1807 DI 10.2175/106143016X14696400495695 PG 115 WC Engineering, Environmental; Environmental Sciences; Limnology; Water Resources SC Engineering; Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA EJ6EU UT WOS:000393312600031 PM 27620108 ER PT J AU Costigan, KH Jaeger, KL Goss, CW Fritz, KM Goebel, PC AF Costigan, Katie H. Jaeger, Kristin L. Goss, Charles W. Fritz, Ken M. Goebel, P. Charles TI Understanding controls on flow permanence in intermittent rivers to aid ecological research: integrating meteorology, geology and land cover SO ECOHYDROLOGY LA English DT Review DE temporary streams; flow cessation; network expansion; connectivity; continuity ID ELECTRICAL-RESISTANCE SENSORS; HEADWATER STREAMS; UNITED-STATES; HYDROLOGIC PERMANENCE; ECOSYSTEM EXPANSION; EPHEMERAL STREAMS; TEMPORAL PATTERNS; NETWORK EXPANSION; DRAINAGE DENSITY; NEW-ZEALAND AB Intermittent rivers, those channels that periodically cease to flow, constitute over half of the total discharge of the global river network and will likely increase in their extent owing to climatic shifts and/or water resources development. Burgeoning research on intermittent river ecology has documented the importance of the meteorologic, geologic and land-cover components of these ecosystems on structuring ecological communities, but mechanisms controlling flow permanence remain poorly understood. Here, we provide a framework of the meteorologic, geologic and land-cover controls on intermittent streamflow across different spatio-temporal scales and identify key research priorities to improve our understanding of intermittent systems so that we are better able to conserve, manage and protect them. Copyright (C) 2015 John Wiley & Sons, Ltd. C1 [Costigan, Katie H.; Jaeger, Kristin L.; Goss, Charles W.; Goebel, P. Charles] Ohio State Univ, Ohio Agr Res & Dev Ctr, Sch Environm & Nat Resources, Wooster, OH 44691 USA. [Costigan, Katie H.] Univ Louisiana Lafayette, Sch Geosci, Lafayette, LA 70504 USA. [Costigan, Katie H.; Fritz, Ken M.] US EPA, Ecol Exposure Res Div, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. RP Costigan, KH (reprint author), Univ Louisiana Lafayette, Sch Geosci, Lafayette, LA 70504 USA. EM costigan@louisiana.edu FU Ohio State University's Climate, Water, and Carbon Program FX Support for this research was provided by The Ohio State University's Climate, Water, and Carbon Program. Joshuah Perkin provided thoughtful ideas for figure generation. Although this work was reviewed by USEPA and approved for publication, it might not necessarily reflect official Agency policy. This manuscript was improved by the thoughtful comments of Robert Payn and four anonymous reviewers. NR 106 TC 1 Z9 1 U1 9 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1936-0584 EI 1936-0592 J9 ECOHYDROLOGY JI Ecohydrology PD OCT PY 2016 VL 9 IS 7 BP 1141 EP 1153 DI 10.1002/eco.1712 PG 13 WC Ecology; Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA EF0NF UT WOS:000390021700001 ER PT J AU Auerbach, DA Buchanan, BP Alexiades, AV Anderson, EP Encalada, AC Larson, EI McManamay, RA Poe, GL Walter, MT Flecker, AS AF Auerbach, Daniel A. Buchanan, Brian P. Alexiades, Alexander V. Anderson, Elizabeth P. Encalada, Andrea C. Larson, Erin I. McManamay, Ryan A. Poe, Gregory L. Walter, M. Todd Flecker, Alexander S. TI Towards catchment classification in data-scarce regions SO ECOHYDROLOGY LA English DT Article DE environmental classification; hydroclimate; flow regime; Colorado; Ecuador ID NATURAL FLOW REGIMES; HYDROLOGICAL CLASSIFICATION; BIODIVERSITY CONSERVATION; FRAMEWORK; RIVERS; MAP AB Assessing spatial variation in hydrologic processes can help to inform freshwater management and advance ecological understanding, yet many areas lack sufficient flow records on which to base classifications. Seeking to address this challenge, we apply concepts developed in data-rich settings to public, global data in order to demonstrate a broadly replicable approach to characterizing hydrologic variation. The proposed approach groups the basins associated with reaches in a river network according to key environmental drivers of hydrologic conditions. This initial study examines Colorado ( USA), where long-term streamflow records permit comparison with previously distinguished flow regime types, and Ecuador, where data limitations preclude such analysis. The flow regime types assigned to gages in Colorado corresponded reasonably well to the classes distinguished from environmental features. The divisions in Ecuador reflected major known biophysical gradients while also providing a higher resolution supplement to an existing depiction of freshwater ecoregions. Although freshwater policy and management decisions occur amidst uncertainty and imperfect knowledge, this classification framework offers a rigorous and transferrable means to distinguish catchments in data-scarce regions. The maps and attributes of the resulting ecohydrologic classes offer a departure point for additional study and data collection programmes such as the placement of stations in under-monitored classes, and the divisions may serve as a preliminary template with which to structure conservation efforts such as environmental flow assessments. Copyright (C) 2015 John Wiley & Sons, Ltd. C1 [Auerbach, Daniel A.; Larson, Erin I.; Flecker, Alexander S.] Cornell Univ, Dept Ecol & Evolutionary Biol, Ithaca, NY 14850 USA. [Buchanan, Brian P.; Walter, M. Todd] Cornell Univ, Dept Biol & Environm Engn, Ithaca, NY USA. [Alexiades, Alexander V.] Cornell Univ, Dept Nat Resources, Fernow Hall, Ithaca, NY 14853 USA. [Anderson, Elizabeth P.] Florida Int Univ, Sch Environm Arts & Soc, Miami, FL 33199 USA. [Encalada, Andrea C.] Univ San Francisco Quito, Lab Ecol Acuat, Colegio Ciencias Biol & Ambientales, Quito, Ecuador. [McManamay, Ryan A.] Oak Ridge Natl Lab, Div Environm Sci, POB 2008, Oak Ridge, TN 37831 USA. [Poe, Gregory L.] Cornell Univ, Dyson Sch Appl Econ & Management, Ithaca, NY USA. US EPA, Off Wetlands Oceans & Watersheds, Washington, DC 20460 USA. Heritage Univ, Dept Environm Sci, Toppenish, WA, Australia. RP Auerbach, DA (reprint author), Cornell Univ, Dept Ecol & Evolutionary Biol, Ithaca, NY 14850 USA. EM da373@cornell.edu OI Larson, Erin/0000-0002-7797-0529; Auerbach, Daniel/0000-0002-3655-5206; Encalada, Andrea C./0000-0003-2497-6086 FU Atkinson Centre for a Sustainable Future at Cornell University; Dimensions of Biodiversity EVOTRAC project [NSF 1045960, NSF 1046408, NSF 1046991]; Nature Conservancy NatureNet fellowship FX This research was stimulated by a workshop in Quito supported by the Atkinson Centre for a Sustainable Future at Cornell University and the Dimensions of Biodiversity EVOTRAC project (NSF 1045960, NSF 1046408, and NSF 1046991). We thank all workshop participants for their contributions to understanding Andean environmental flow needs. DA is grateful for support from The Nature Conservancy NatureNet fellowship. Heather Tallis and Spencer Meyer offered thoughtful suggestions that greatly improved the manuscript. We thank Jacob Bien and Erika Mudrak for valuable conversation regarding statistical options. NR 40 TC 0 Z9 0 U1 4 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1936-0584 EI 1936-0592 J9 ECOHYDROLOGY JI Ecohydrology PD OCT PY 2016 VL 9 IS 7 BP 1235 EP 1247 DI 10.1002/eco.1721 PG 13 WC Ecology; Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA EF0NF UT WOS:000390021700008 ER PT J AU Bennett, MG Whiles, MR Whitledge, GW AF Bennett, Micah G. Whiles, Matt R. Whitledge, Gregory W. TI Population-level responses of life history traits to flow regime in three common stream fish species SO ECOHYDROLOGY LA English DT Article DE flow-ecology; reproduction; trait-based; functional trait ID FRESH-WATER FISH; HYDROLOGY CONSTRAIN; COMMUNITY ECOLOGY; FUNCTIONAL TRAITS; FRENCH STREAMS; SCALE ANALYSIS; UNITED-STATES; EGG NUMBER; STRATEGIES; ASSEMBLAGES AB Trait-based approaches may improve understanding in ecology by linking environmental variation to fitness-related characteristics of species. Most trait-environment studies focus on assemblage-level relationships; yet intraspecific trait variation is important for community, ecosystem, and evolutionary processes, and has substantial implications for these approaches. Assessing population-level trait-environment relationships could test the generality of trait models whilst assessing intraspecific variation. We evaluated the generality of the trilateral life history model (TLHM opportunistic, periodic, and equilibrium endpoints) for fishes - a well-studied trait-environment model at the assemblage level - to populations of three stream fishes in the Midwestern United States in relation to flow regime. The TLHM adequately described major trade-offs in traits amongst populations in all species. Some TLHM flow-based predictions were confirmed, with periodic traits (high fecundity) favoured at sites with greater flow seasonality and lower flow variability in two species, and equilibrium traits (large eggs) in more stable flow conditions in two species. Size at maturity was also inversely related to variability in one species. However, relationships contradicting the TLHM were also found. Coupled with the explanatory power of the TLHM for populations, supporting relationships suggest that synthesizing habitat template models with demographic life history theory could be valuable. Trait-environment models that are well-supported at multiple levels of biological organization could improve understanding of the impacts of environmental change on populations and communities and the valuable ecosystem services that they support. Copyright (C) 2016 John Wiley & Sons, Ltd. C1 [Bennett, Micah G.; Whiles, Matt R.; Whitledge, Gregory W.] Southern Illinois Univ, Ctr Ecol, Dept Zool, 1125 Lincoln Dr,Mail Code 6501, Carbondale, IL 62901 USA. [Whitledge, Gregory W.] Southern Illinois Univ, Ctr Fisheries Aquaculture & Aquat Sci, 1125 Lincoln Dr,Mail Code 6511, Carbondale, IL 62901 USA. RP Bennett, MG (reprint author), US EPA, Off Res & Dev, Washington, DC 20460 USA. EM micahgbennett@yahoo.com FU SIU NSF-IGERT Program in Watershed Science and Policy; Graduate Professional Student Council FX The SIU NSF-IGERT Program in Watershed Science and Policy and the Graduate Professional Student Council supported this research. Thanks to J. Adams, K. Baumann, A. Beattie, T. Egdorf, J. Fulgoni, H. Rantala, L. Shoup, and B. Zuniga-Cespedes for field help. Sampling was conducted with permits from IL, IN, KS, MN, MO, NE, OH, and IACUC. K. Gido provided useful discussions that greatly improved the manuscript, and the Freshwater Ecology Lab at SIU provided helpful comments and edits on an earlier draft of the manuscript. NR 63 TC 0 Z9 0 U1 2 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1936-0584 EI 1936-0592 J9 ECOHYDROLOGY JI Ecohydrology PD OCT PY 2016 VL 9 IS 7 BP 1388 EP 1399 DI 10.1002/eco.1734 PG 12 WC Ecology; Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA EF0NF UT WOS:000390021700019 ER PT J AU Shoemaker, JA AF Shoemaker, Jody A. TI Development and Multi-laboratory Verification of US EPA Method 543 for the Analysis of Drinking Water Contaminants by Online Solid Phase Extraction-LC-MS-MS SO JOURNAL OF CHROMATOGRAPHIC SCIENCE LA English DT Article ID TANDEM MASS-SPECTROMETRY; CHROMATOGRAPHY; SAMPLES; PESTICIDES; COLUMN; LEVEL AB A drinking water method for seven pesticides and pesticide degradates is presented that addresses the occurrence monitoring needs of the US Environmental Protection Agency (EPA) for a future Unregulated Contaminant Monitoring Regulation (UCMR). The method employs online solid phase extraction-liquid chromatography-tandem mass spectrometry (SPE-LC-MS-MS). Online SPE-LC-MS-MS has the potential to offer cost-effective, faster, more sensitive and more rugged methods than the traditional offline SPE approach due to complete automation of the SPE process, as well as seamless integration with the LC-MS-MS system. The method uses 2-chloroacetamide, ascorbic acid and Trizma to preserve the drinking water samples for up to 28 days. The mean recoveries in drinking water (from a surface water source) fortified with method analytes are 87.1-112% with relative standard deviations of < 14%. Single laboratory lowest concentration minimum reporting levels of 0.27-1.7 ng/L are demonstrated with this methodology. Multi-laboratory data are presented that demonstrate method ruggedness and transferability. The final method meets all of the EPA's UCMR survey requirements for sample collection and storage, precision, accuracy, and sensitivity. C1 [Shoemaker, Jody A.] US EPA, Off Res & Dev, Natl Exposure Res Lab, MS 564,26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. RP Shoemaker, JA (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, MS 564,26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM shoemaker.jody@epa.gov FU Waters Corporation [05-006-10] FX The author wishes to acknowledge Waters Corporation for their support of this research through the loan of the Waters Open Architecture UPLC Online SPE system to the EPA under Personal Property Loan Agreement Loan No. 05-006-10. In addition, the author recognizes the assistance of the analysts and laboratories for their participation in the multi-laboratory verification studies: (a) Don Noot and Ralph Hindle of Vogon Laboratory Services Ltd, Cochrane, AB, Canada and (b) Kevin Durk, Thomas Schneider and Amanda Comando of Suffolk County Water Authority, Hauppauge, NY. NR 22 TC 0 Z9 0 U1 1 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0021-9665 EI 1945-239X J9 J CHROMATOGR SCI JI J. Chromatogr. Sci. PD OCT PY 2016 VL 54 IS 9 BP 1532 EP 1539 DI 10.1093/chromsci/bmw098 PG 8 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA ED8RT UT WOS:000389139300010 ER PT J AU Messner, MJ Berger, P AF Messner, Michael J. Berger, Philip TI Cryptosporidium Infection Risk: Results of New Dose-Response Modeling SO RISK ANALYSIS LA English DT Article DE Beta-Poisson; Cryptosporidium; dose-response; exponential with immunity; fractional Poisson ID DRINKING-WATER; HEALTHY-ADULTS; OUTBREAK; MILWAUKEE; NOROVIRUS; HOMINIS; HUMANS; PARVUM AB Cryptosporidium human dose-response data from seven species/isolates are used to investigate six models of varying complexity that estimate infection probability as a function of dose. Previous models attempt to explicitly account for virulence differences among C. parvum isolates, using three or six species/isolates. Four (two new) models assume species/isolate differences are insignificant and three of these (all but exponential) allow for variable human susceptibility. These three human-focused models (fractional Poisson, exponential with immunity and beta-Poisson) are relatively simple yet fit the data significantly better than the more complex isolate-focused models. Among these three, the one-parameter fractional Poisson model is the simplest but assumes that all Cryptosporidium oocysts used in the studies were capable of initiating infection. The exponential with immunity model does not require such an assumption and includes the fractional Poisson as a special case. The fractional Poisson model is an upper bound of the exponential with immunity model and applies when all oocysts are capable of initiating infection. The beta Poisson model does not allow an immune human subpopulation; thus infection probability approaches 100% as dose becomes huge. All three of these models predict significantly (>10x) greater risk at the low doses that consumers might receive if exposed through drinking water or other environmental exposure (e.g., 72% vs. 4% infection probability for a one oocyst dose) than previously predicted. This new insight into Cryptosporidium risk suggests additional inactivation and removal via treatment may be needed to meet any specified risk target, such as a suggested 10(-4) annual risk of Cryptosporidium infection. C1 [Messner, Michael J.; Berger, Philip] US EPA, Off Water, Washington, DC 20460 USA. RP Messner, MJ (reprint author), Off Ground Water & Drinking Water 4607M, 1200 Penn Ave NW, Washington, DC 20460 USA. EM Mess-ner.Michael@epa.gov NR 28 TC 1 Z9 1 U1 2 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0272-4332 EI 1539-6924 J9 RISK ANAL JI Risk Anal. PD OCT PY 2016 VL 36 IS 10 BP 1969 EP 1982 DI 10.1111/risa.12541 PG 14 WC Public, Environmental & Occupational Health; Mathematics, Interdisciplinary Applications; Social Sciences, Mathematical Methods SC Public, Environmental & Occupational Health; Mathematics; Mathematical Methods In Social Sciences GA ED6RZ UT WOS:000388984900011 PM 26773806 ER PT J AU Zhang, HS Sanchez, LJ Spears, M Sarlashkar, J Robertson, D Ross, M AF Zhang, Houshun Sanchez, L. James Spears, Matthew Sarlashkar, Jayant Robertson, Dennis Ross, Michael TI Cycle-Average Heavy-Duty Engine Test Procedure for Full Vehicle Certification - Numerical Algorithms for Interpreting Cycle-Average Fuel Maps SO SAE International Journal of Commercial Vehicles LA English DT Article AB In June of 2015, the Environmental Protection Agency and the National Highway Traffic Safety Administration issued a Notice of Proposed Rulemaking to further reduce greenhouse gas emissions and improve the fuel efficiency of medium-and heavy-duty vehicles. The agencies proposed that vehicle manufacturers would certify vehicles to the standards by using the agencies' Greenhouse Gas Emission Model (GEM). The agencies also proposed a steady-state engine test procedure for generating GEM inputs to represent the vehicle's engine performance. In the proposal the agencies also requested comment on an alternative engine test procedure, the details of which were published in two separate 2015 SAE Technical Papers [1, 2]. As an alternative to the proposed steady-state engine test procedure, these papers presented a cycle-average test procedure. The papers also explored how a range of vehicle configurations could be defined and selected for generating the engine duty cycles for this test procedure. In addition, these papers described and used a simple interpolation-based numerical algorithm for determining the fuel consumption of a vehicle configuration based on a cycle-average engine "fuel map" that was generated via the cycle-average engine test procedure. This paper is a continuation of this earlier work [1], and this particular paper presents a more comprehensive evaluation of a range of numerical algorithms for determining fuel consumption values from a cycle-average engine fuel map. These numerical algorithms include interpolation and extrapolation schemes as well as different linear and non-linear equations, where the equations' coefficients were fitted via least-squares regression. The selection of independent and dependent variables for all of these numerical methods was explored in detail. It is shown that the most robust numerical algorithm that we explored specifies fuel mass as the dependent variable, and a linear combination of the ratio of average engine speed to average vehicle speed and cycle work as the two independent variables. It is demonstrated that the cycle-average test procedure, combined with a robust numerical algorithm for interpreting the cycle-average fuel map, can effectively predict the fuel consumption of an engine in different vehicle configurations, including configurations with different parent and child engine ratings and a wide range of transmissions. It is also shown that the cycle-average test procedure represents transient engine performance more accurately than the agencies' proposed steady-state test procedure. C1 [Zhang, Houshun; Sanchez, L. James; Spears, Matthew] US EPA, Washington, DC USA. [Sarlashkar, Jayant; Robertson, Dennis; Ross, Michael] Southwest Res Inst, San Antonio, TX USA. RP Zhang, HS (reprint author), US EPA, Assessment & Stand Div, Off Transportat & Air Qual, 2000 Traverwood Dr, Ann Arbor, MI 48105 USA. EM zhang.houshun@epa.gov NR 12 TC 0 Z9 0 U1 0 U2 0 PU SAE INT PI WARRENDALE PA 400 COMMONWEALTH DR, WARRENDALE, PA 15096 USA SN 1946-391X EI 1946-3928 J9 SAE INT J COMMER VEH JI SAE Int. J. Commer. Veh. PD OCT PY 2016 VL 9 IS 2 BP 105 EP 119 DI 10.4271/2016-01-8018 PG 15 WC Transportation Science & Technology SC Transportation GA ED9ZX UT WOS:000389233800008 ER PT J AU Waltzer, S Johnson, D Wei, K Wilson, J AF Waltzer, Sam Johnson, Dennis Wei, Kuang Wilson, Jonathan TI Fuel-Savings from Aerodynamic Efficiency Improvements for Combination Tractor-Trailers Relative to Vehicle Speed SO SAE International Journal of Commercial Vehicles LA English DT Article AB Commercial, class-8 tractor-trailers were tested to develop a relationship between vehicle speed and fuel savings associated with trailer aerodynamic technologies representative of typical long-haul freight applications. This research seeks to address a concern that many long-distance U.S. freight companies hold that, as vehicle speed is reduced, the fuel savings benefits of aerodynamic technologies are not realized. In this paper, the reductions in fuel consumption were measured using the SAE J1231 test method and thru-engine fueling rates recorded from the vehicle's electronic data stream. Constant speed testing was conducted on road at different speeds and corresponding testing was conducted on track to confirm results. Data was collected at four (4) vehicle speeds: 35, 45, 55, and 62 miles per hour. Two different trailer aerodynamic configurations were evaluated relative to a baseline tractor trailer. Reductions in fuel consumption displayed a strong relationship to vehicle speed, with aerodynamic improvements demonstrating a maximum reduction of fuel consumption of nine (9) percent relative to the baseline at 62 miles per hour. Results at high vehicle speeds are consistent with earlier wind tunnel studies published for trailer aerodynamic technologies. Reductions in fuel consumption demonstrated at 35, 45 and 55 miles per hour are consistent with anticipated performance based on changes in the coefficient of drag for the aerodynamic technology packages tested. At speeds as slow as 35mph, a trailer side skirt and full trailer aerodynamic package demonstrated fuel savings of over 2 and 3 percent, respectively. Fuel savings results at high speeds were relatively insensitive to baseline selection when compared to five (5) different baselines. The relationships derived from the tests provide a good fit (i.e., high R-2 values) to mathematical regression models and suggest these curves can be used to estimate reductions in fuel consumption savings for aerodynamic technologies for modern class-8 tractor-trailers operating at different vehicle speeds. When applying the SAE J1321 approach (i.e., use of a control vehicle and calculating fuel savings relative to a baseline), ECU-derived fuel savings generally agree with the gravimetric measurement. C1 [Waltzer, Sam; Johnson, Dennis; Wei, Kuang; Wilson, Jonathan] US Environm Protect Agcy, Washington, DC 20004 USA. RP Waltzer, S (reprint author), US Environm Protect Agcy, Washington, DC 20004 USA. NR 3 TC 0 Z9 0 U1 2 U2 2 PU SAE INT PI WARRENDALE PA 400 COMMONWEALTH DR, WARRENDALE, PA 15096 USA SN 1946-391X EI 1946-3928 J9 SAE INT J COMMER VEH JI SAE Int. J. Commer. Veh. PD OCT PY 2016 VL 9 IS 2 BP 321 EP 330 DI 10.4271/2016-01-8133 PG 10 WC Transportation Science & Technology SC Transportation GA ED9ZX UT WOS:000389233800022 ER PT J AU Hart, EM Barmby, P LeBauer, D Michonneau, F Mount, S Mulrooney, P Poisot, T Woo, KH Zimmerman, NB Hollister, JW AF Hart, Edmund M. Barmby, Pauline LeBauer, David Michonneau, Francois Mount, Sarah Mulrooney, Patrick Poisot, Timothee Woo, Kara H. Zimmerman, Naupaka B. Hollister, Jeffrey W. TI Ten Simple Rules for Digital Data Storage SO PLOS COMPUTATIONAL BIOLOGY LA English DT Editorial Material ID ECOLOGY; SCIENCE; MODELS C1 [Hart, Edmund M.] Univ Vermont, Dept Biol, Burlington, VT 05405 USA. [Barmby, Pauline] Univ Western Ontario, Dept Phys & Astron, London, ON, Canada. [LeBauer, David] Univ Illinois, Natl Ctr Supercomp Applicat, Urbana, IL USA. [LeBauer, David] Inst Genom Biol, Urbana, IL USA. [Michonneau, Francois] Univ Florida, Florida Museum Nat Hist, iDigBio, Gainesville, FL 32611 USA. [Michonneau, Francois] Univ Florida, Whitney Lab Marine Biosci, Gainesville, FL USA. [Mount, Sarah] Kings Coll London, Dept Informat, London, England. [Mulrooney, Patrick] Univ Calif San Diego, San Diego Supercomp Ctr, San Diego, CA 92103 USA. [Poisot, Timothee] Univ Montreal, Dept Sci Biol, Montreal, PQ, Canada. [Woo, Kara H.] Washington State Univ, Ctr Environm Res Educ & Outreach, Pullman, WA 99164 USA. [Zimmerman, Naupaka B.] Univ Arizona, Sch Plant Sci, Tucson, AZ USA. [Hollister, Jeffrey W.] US EPA, Atlantic Ecol Div, Narragansett, RI USA. RP Hart, EM (reprint author), Univ Vermont, Dept Biol, Burlington, VT 05405 USA. EM edmund.m.hart@gmail.com OI Zimmerman, Naupaka/0000-0003-2168-6390; Hart, Edmund/0000-0001-7367-7969; Woo, Kara/0000-0002-5125-4188 NR 36 TC 0 Z9 0 U1 3 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-734X EI 1553-7358 J9 PLOS COMPUT BIOL JI PLoS Comput. Biol. PD OCT PY 2016 VL 12 IS 10 AR e1005097 DI 10.1371/journal.pcbi.1005097 PG 12 WC Biochemical Research Methods; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Mathematical & Computational Biology GA EB8SC UT WOS:000387660200011 PM 27764088 ER PT J AU Galletti, A Seo, S Joo, SH Su, C Blackwelder, P AF Galletti, Andrea Seo, Seokju Joo, Sung Hee Su, Chunming Blackwelder, Pat TI Effects of titanium dioxide nanoparticles derived from consumer products on the marine diatom Thalassiosira pseudonana SO ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH LA English DT Article DE Nanoproducts; Commercial TiO2; Marine environments; Toxicity; Exposure; Algae ID ZINC-OXIDE NANOPARTICLES; TIO2 NANOPARTICLES; DUNALIELLA-TERTIOLECTA; RUTILE NANOPARTICLES; AQUATIC ENVIRONMENTS; GROWTH-INHIBITION; WATER-TREATMENT; NANOMATERIALS; SUNSCREENS; TOXICITY AB Increased manufacture of TiO2 nanoproducts has caused concern about the potential toxicity of these products to the environment and in public health. Identification and confirmation of the presence of TiO2 nanoparticles derived from consumer products as opposed to industrial TiO2 NPs warrant examination in exploring the significance of their release and resultant impacts on the environment. To this end, we examined the significance of the release of these particles and their toxic effect on the marine diatom algae Thalassiosira pseudonana. Our results indicate that nano-TiO2 sunscreen and toothpaste exhibit more toxicity in comparison to industrial TiO2 and inhibited the growth of the marine diatom T. pseudonana. This inhibition was proportional to the exposure time and concentrations of nano-TiO2. Our findings indicate a significant effect, and therefore, further research is warranted in evaluation and assessment of the toxicity of modified nano-TiO2 derived from consumer products and their physicochemical properties. C1 [Galletti, Andrea; Seo, Seokju; Joo, Sung Hee] Univ Miami, Dept Civil Architectural & Environm Engn, 1251 Mem Dr McArthur Engn Bldg, Coral Gables, FL 33146 USA. [Su, Chunming] US EPA, Ground Water & Ecosyst Restorat Div, Natl Risk Management, Res Lab, 919 Kerr Res Dr, Ada, OK 74820 USA. [Blackwelder, Pat] Univ Miami, Dept Marine Geosci, 4600 Rickenbacker Causeway, Miami, FL 33149 USA. RP Joo, SH (reprint author), Univ Miami, Dept Civil Architectural & Environm Engn, 1251 Mem Dr McArthur Engn Bldg, Coral Gables, FL 33146 USA. EM s.joo1@miami.edu OI Galletti, Andrea/0000-0001-6976-4963 NR 60 TC 1 Z9 1 U1 11 U2 11 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0944-1344 EI 1614-7499 J9 ENVIRON SCI POLLUT R JI Environ. Sci. Pollut. Res. PD OCT PY 2016 VL 23 IS 20 BP 21113 EP 21122 DI 10.1007/s11356-016-7556-6 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA EB7VM UT WOS:000387599100095 PM 27596588 ER PT J AU Grear, JS AF Grear, Jason S. TI Translating crustacean biological responses from CO2 bubbling experiments into population-level predictions SO POPULATION ECOLOGY LA English DT Article DE Carbon dioxide; Cohort; Demography; Ocean acidification; pH ID OCEAN ACIDIFICATION; MARINE ORGANISMS; GROWTH RATE; VIABILITY; DYNAMICS; MODELS AB Many studies of animal responses to ocean acidification focus on uniformly conditioned age cohorts that lack complexities typically found in wild populations. These studies have become the primary data source for predicting higher level ecological effects, but the roles of intraspecific interactions in re-shaping biological, demographic and evolutionary responses are not commonly considered. To explore this problem, I assessed responses in the mysid Americamysis bahia to bubbling of CO2-enriched and un-enriched air into the seawater supply in flow-through aquariums. I conducted one experiment using isolated age cohorts and a separate experiment using intact populations. The seawater supply was continuously input from Narragansett Bay (Rhode Island, USA). The 28-day cohort study was maintained without resource or spatial limitations, whereas the 5-month population study consisted of stage-structured populations that were allowed to self-regulate. These differences are common features of experiments and were intentionally retained to demonstrate the effect of methodological approaches on perceptions of effect mechanisms. The CO2 treatment reduced neonate abundance in the cohort experiment (24% reduction due to a mean pH difference of -0.27) but not in the population experiment, where effects were small and were strongest for adult and stage 1 survival (3% change due to a mean pH difference of -0.25). I also found evidence of competition in the population experiment, further complicating relationships with cohort experiments. These results point to limitations of standard cohort tests. Such experiments should be complimented by studies of intact populations where responses may be affected by evolution, acclimation, and competition. C1 [Grear, Jason S.] US EPA, Atlantic Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, 27 Tarzwell Dr, Narragansett, RI 02882 USA. RP Grear, JS (reprint author), US EPA, Atlantic Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, 27 Tarzwell Dr, Narragansett, RI 02882 USA. EM grear.jason@epa.gov FU EPA FX I am grateful to Ruth Gutjahr-Gobell and Doranne Borsay Horowitz for their assistance during the mysid experiments. Harriet Booth, Adam Pimenta and Brenda Rashleigh provided helpful comments on an earlier version of this manuscript. This manuscript was submitted with tracking number ORD-010744 by the Atlantic Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency (EPA). Although the research described in this article was funded by EPA, it has not been subjected to agency review and does not necessarily reflect the views of the agency. NR 35 TC 0 Z9 0 U1 6 U2 6 PU SPRINGER JAPAN KK PI TOKYO PA CHIYODA FIRST BLDG EAST, 3-8-1 NISHI-KANDA, CHIYODA-KU, TOKYO, 101-0065, JAPAN SN 1438-3896 EI 1438-390X J9 POPUL ECOL JI Popul. Ecol. PD OCT PY 2016 VL 58 IS 4 BP 515 EP 524 DI 10.1007/s10144-016-0562-1 PG 10 WC Ecology SC Environmental Sciences & Ecology GA EC4NZ UT WOS:000388110700004 ER PT J AU LaLone, CA Villeneuve, DL Lyons, D Helgen, HW Robinson, SL Swintek, JA Saari, TW Ankley, GT AF LaLone, Carlie A. Villeneuve, Daniel L. Lyons, David Helgen, Henry W. Robinson, Serina L. Swintek, Joseph A. Saari, Travis W. Ankley, Gerald T. TI Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS): A Web-Based Tool for Addressing the Challenges of Cross-Species Extrapolation of Chemical Toxicity SO TOXICOLOGICAL SCIENCES LA English DT Article DE sequence similarity; methoxyfenozide; tebufenozide; neonicotinoids; strobilurins; pollinator susceptibility ID NICOTINIC ACETYLCHOLINE-RECEPTOR; CYTOCHROME-B GENE; LOOP-D; NEONICOTINOID INSECTICIDES; ECDYSONE RECEPTOR; RISK-ASSESSMENT; FUNGICIDES; RESISTANCE; AGONIST; AZOXYSTROBIN AB Conservation of a molecular target across species can be used as a line-of-evidence to predict the likelihood of chemical susceptibility. The web-based Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS; https://seqapass.epa.gov/seqapass/) application was developed to simplify, streamline, and quantitatively assess protein sequence/structural similarity across taxonomic groups as a means to predict relative intrinsic susceptibility. The intent of the tool is to allow for evaluation of any potential protein target while remaining amenable to variable degrees of protein characterization, in the context of available information about the chemical/protein interaction and the molecular target itself. To accommodate this flexibility in the analysis, 3 levels of evaluation were developed. The first level of the SeqAPASS analysis compares primary amino acid sequences to a query sequence, calculating a metric for sequence similarity (including detection of orthologs); the second level evaluates sequence similarity within selected functional domains (eg, ligand-binding domain); and the third level of analysis compares individual amino acid residue positions of importance for protein conformation and/or interaction with the chemical upon binding. Each level of the SeqAPASS analysis provides additional evidence to apply toward rapid, screening-level assessments of probable cross species susceptibility. Such analyses can support prioritization of chemicals for further evaluation, selection of appropriate species for testing, extrapolation of empirical toxicity data, and/or assessment of the cross-species relevance of adverse outcome pathways. Three case studies are described herein to demonstrate application of the SeqAPASS tool: the first 2 focused on predictions of pollinator susceptibility to molt-accelerating compounds and neonicotinoid insecticides, and the third on evaluation of cross-species susceptibility to strobilurin fungicides. These analyses illustrate challenges in species extrapolation and demonstrate the broad utility of SeqAPASS for risk-based decision making and research. C1 [LaLone, Carlie A.; Villeneuve, Daniel L.; Saari, Travis W.; Ankley, Gerald T.] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Mid Continent Ecol Div, Duluth, MN 55804 USA. [Lyons, David] US EPA, Off Res & Dev, Natl Ctr Computat Toxicol, Res Triangle Pk, NC USA. [Helgen, Henry W.] CSC Govt Solut LLC, Willmar, MN USA. [Robinson, Serina L.] St Olaf Coll, Dept Chem, Northfield, MN USA. [Swintek, Joseph A.] Badger Tech Serv, Duluth, MN USA. RP LaLone, CA (reprint author), US EPA Mid Continent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA. EM lalone.carlie@epa.gov RI Lyons, David/G-3459-2011 OI Lyons, David/0000-0002-2966-5634 FU U.S. Environmental Protection Agency FX This work was supported by the U.S. Environmental Protection Agency. NR 65 TC 1 Z9 1 U1 2 U2 2 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD OCT PY 2016 VL 153 IS 2 BP 228 EP 245 DI 10.1093/toxsci/kfw119 PG 18 WC Toxicology SC Toxicology GA EC1XN UT WOS:000387902200003 PM 27370413 ER PT J AU Conley, JM Hannas, BR Furr, JR Wilson, VS Gray, LE AF Conley, Justin M. Hannas, Bethany R. Furr, Johnathan R. Wilson, Vickie S. Gray, L. Earl, Jr. TI A Demonstration of the Uncertainty in Predicting the Estrogenic Activity of Individual Chemicals and Mixtures From an In Vitro Estrogen Receptor Transcriptional Activation Assay (T47D-KBluc) to the In Vivo Uterotrophic Assay Using Oral Exposure SO TOXICOLOGICAL SCIENCES LA English DT Article DE mixture; T47D-KBluc; bisphenols; estrogen; uterotrophic; oral exposure ID BISPHENOL-A SUBSTITUTES; UNITED-STATES; ENVIRONMENTAL ESTROGENS; DRINKING-WATER; ER-ALPHA; METABOLISM; RATS; PHTHALATE; METHOXYCHLOR; ESTRADIOL AB In vitro estrogen receptor assays are valuable tools for identifying environmental samples and chemicals that display estrogenic activity. However, in vitro potency cannot necessarily be extrapolated to estimates of in vivo potency because in vitro assays are currently unable to fully account for absorption, distribution, metabolism, and excretion. To explore this issue, we calculated relative potency factors (RPF), using 17 alpha-ethinyl estradiol (EE2) as the reference compound, for several chemicals and mixtures in the T47D-KBluc estrogen receptor transactivation assay. In vitro RPFs were used to predict rat oral uterotrophic assay responses for these chemicals and mixtures. EE2, 17 beta-estradiol (E2), benzyl-butyl phthalate (BBP), bisphenol-A (BPA), bisphenol-AF (BPAF), bisphenol-C (BPC), bisphenol-S (BPS), and methoxychlor (MET) were tested individually, while BPS + MET, BPAF + MET, and BPAF + BPC + BPS + EE2 + MET were tested as equipotent mixtures. In vivo ED50 values for BPA, BPAF, and BPC were accurately predicted using in vitro data; however, E2 was less potent than predicted, BBP was a false positive, and BPS and MET were 76.6 and 368.3-fold more active in vivo than predicted from the in vitro potency, respectively. Further, mixture ED50 values were more accurately predicted by the dose addition model using individual chemical in vivo uterotrophic data (0.7-1.5-fold difference from observed) than in vitro data (1.4-86.8-fold). Overall, these data illustrate the potential for both underestimating and overestimating in vivo potency from predictions made with in vitro data for compounds that undergo substantial disposition following oral administration. Accounting for aspects of toxicokinetics, notably metabolism, in in vitro models will be necessary for accurate in vitro-to-in vivo extrapolations. C1 [Conley, Justin M.; Hannas, Bethany R.; Furr, Johnathan R.; Wilson, Vickie S.; Gray, L. Earl, Jr.] US EPA, Toxic Assessment Div, Res Triangle Pk, NC 27711 USA. [Hannas, Bethany R.] Dow Chem Co USA, Midland, MI 48674 USA. [Furr, Johnathan R.] Southern Res, Birmingham, AL 35205 USA. RP Gray, LE (reprint author), US EPA, B105-04,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM gray.earl@epa.gov OI Conley, Justin M./0000-0002-6622-5769; Wilson, Vickie/0000-0003-1661-8481 FU USEPA [IA: RW-75-92285501-1]; National Toxicology Program at the National Institute of Environmental Health Sciences [IA: RW-75-92285501-1]; USEPA FX Funding for this work was provided by an interagency agreement between the USEPA and the National Toxicology Program at the National Institute of Environmental Health Sciences (IA: RW-75-92285501-1) and the USEPA Safe and Sustainable Water Resources and Chemical Safety for Sustainability Research Programs. NR 70 TC 0 Z9 0 U1 8 U2 8 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD OCT PY 2016 VL 153 IS 2 BP 382 EP 395 DI 10.1093/toxsci/kfw134 PG 14 WC Toxicology SC Toxicology GA EC1XN UT WOS:000387902200015 PM 27473340 ER PT J AU Procter, AC Kaplan, PO Araujo, R AF Procter, Andrew C. Kaplan, P. Ozge Araujo, Rochelle TI Net Zero Fort Carson SO JOURNAL OF INDUSTRIAL ECOLOGY LA English DT Article DE industrial ecology; military; renewable energy; system dynamics; urban metabolism; water recycling ID SOLID-WASTE GENERATION; URBAN METABOLISM; CITIES; SUSTAINABILITY; INDICATORS AB Military bases resemble small cities and face similar sustainability challenges. As pilot studies in the U.S. Army Net Zero program, 17 locations are moving to 100% renewable energy, zero depletion of water resources, and/or zero waste to landfill by 2020. Some bases target net zero in a single area, such as water, whereas two bases, including Fort Carson, Colorado, target net zero in all three areas. We investigated sustainability strategies that appear when multiple areas (energy, water, and waste) are integrated. A system dynamics model is used to simulate urban metabolism through Fort Carson's energy, water, and waste systems. Integrated scenarios reduce environmental impact up to 46% from the 2010 baseline, whereas single-dimension scenarios (energy-only, water-only, and waste-only) reduce impact, at most, 20%. Energy conserving technologies offer mutual gains, reducing annual energy use 18% and water use 15%. Renewable energy sources present trade-offs: Concentrating solar power could supply 11% of energy demand, but increase water demand 2%. Waste to energy could supply 40% of energy demand and reduce waste to landfill >80%, but increase water demand between 1% and 22% depending on cooling system and waste tonnage. Outcomes depend on how the Fort Carson system is defined, because some components represent multiple net zero areas (food represents waste and energy), and some actions require embodied resources (energy generation potentially requires water and off-base feedstock). We suggest that integrating multiple net zero goals can lead to lower environmental impact for military bases. C1 [Procter, Andrew C.] US EPA, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. [Kaplan, P. Ozge] US EPA, Natl Risk Management Res Lab, Res Triangle Pk, NC USA. [Araujo, Rochelle] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC USA. RP Procter, AC (reprint author), US EPA, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM acprocter@gmail.com NR 61 TC 0 Z9 0 U1 2 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1088-1980 EI 1530-9290 J9 J IND ECOL JI J. Ind. Ecol. PD OCT PY 2016 VL 20 IS 5 BP 1134 EP 1147 DI 10.1111/jiec.12359 PG 14 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental; Environmental Sciences SC Science & Technology - Other Topics; Engineering; Environmental Sciences & Ecology GA EB4FY UT WOS:000387326900013 ER PT J AU Forsyth, DK Riseng, CM Wehrly, KE Mason, LA Gaiot, J Hollenhorst, T Johnston, CM Wyrzykowski, C Annis, G Castiglione, C Todd, K Robertson, M Infante, DM Wang, LZ McKenna, JE Whelan, G AF Forsyth, Danielle K. Riseng, Catherine M. Wehrly, Kevin E. Mason, Lacey A. Gaiot, John Hollenhorst, Torn Johnston, Craig M. Wyrzykowski, Conrad Annis, Gust Castiglione, Chris Todd, Kent Robertson, Mike Infante, Dana M. Wang, Lizhu McKenna, James E. Whelan, Gary TI THE GREAT LAKES HYDROGRAPHY DATASET: CONSISTENT, BINATIONAL WATERSHEDS FOR THE LAURENTIAN GREAT LAKES BASIN SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article DE watersheds; Laurentian Great Lakes; Geographic Information System (GIS); surface water hydrology ID NEARSHORE AB Ecosystem-based management of the Laurentian Great Lakes, which spans both the United States and Canada, is hampered by the lack of consistent binational watersheds for the entire Basin. Using comparable data sources and consistent methods, we developed spatially equivalent watershed boundaries for the binational extent of the Basin to create the Great Lakes Hydrography Dataset (GLHD). The GLHD consists of 5,589 watersheds for the entire Basin, covering a total area of approximately 547,967 km(2), or about twice the 247,003 km2 surface water area of the Great Lakes. The GLHD improves upon existing watershed efforts by delineating watersheds for the entire Basin using consistent methods; enhancing the precision of watershed delineation using recently developed flow direction grids that have been hydrologically enforced and vetted by provincial and federal water resource agencies; and increasing the accuracy of watershed boundaries by enforcing embayments, delineating watersheds on islands, and delineating watersheds for all tributaries draining to connecting channels. In addition, the GLHD is packaged in a publically available geodatabase that includes synthetic stream networks, reach catchments, watershed boundaries, a broad set of attribute data for each tributary, and metadata documenting methodology. The GLHD provides a common set of watersheds and associated hydrography data for the Basin that will enhance binational efforts to protect and restore the Great Lakes. C1 [Forsyth, Danielle K.; Wehrly, Kevin E.] Michigan Dept Nat Resources, Fisheries Res Inst, 400 North Ingalls Bldg,NIB G250, Ann Arbor, MI 48109 USA. [Forsyth, Danielle K.; Wehrly, Kevin E.] Univ Michigan, 400 North Ingalls Bldg,NIB G250, Ann Arbor, MI 48109 USA. [Riseng, Catherine M.; Mason, Lacey A.] Univ Michigan, Sch Nat Resources & Environm, Ann Arbor, MI 48109 USA. [Gaiot, John; Todd, Kent; Robertson, Mike] Ontario Minist Nat Resources & Forestry, Peterborough, ON K9J 8M5, Canada. [Hollenhorst, Torn] US EPA, Midcontinent Ecol Div, Duluth, MN 55804 USA. [Johnston, Craig M.] US Geol Survey, New England Water Sci Ctr, Pembroke, NH 03275 USA. [Wyrzykowski, Conrad] Agr & Agri Food Canada, Winnipeg, MB R3C 3G7, Canada. [Annis, Gust] Nat Conservancy Michigan, Lansing, MI 48906 USA. [Castiglione, Chris] US Fish & Wildlife Serv, Lower Great Lakes Fish & Wildlife Conservat Off, Basom, NY 14013 USA. [Infante, Dana M.] Michigan State Univ, Dept Fisheries & Wildlife, E Lansing, MI 48824 USA. [Wang, Lizhu] Int Joint Commiss, Great Lakes Off, Detroit, MI 48232 USA. [McKenna, James E.] US Geol Survey, Great Lakes Sci Ctr, Cortland, NY 13045 USA. [Whelan, Gary] Michigan Dept Nat Resources, Div Fisheries, Lansing, MI 48909 USA. RP Forsyth, DK (reprint author), Michigan Dept Nat Resources, Fisheries Res Inst, 400 North Ingalls Bldg,NIB G250, Ann Arbor, MI 48109 USA.; Forsyth, DK (reprint author), Univ Michigan, 400 North Ingalls Bldg,NIB G250, Ann Arbor, MI 48109 USA. EM ForsythDl@Michigan.gov RI Forsyth, Danielle/E-4706-2015; OI Forsyth, Danielle/0000-0001-9878-7320; Mason, Lacey/0000-0003-1541-3134 FU Great Lakes Fishery Trust; Michigan Department of Natural Resources; Ontario Ministry of Natural Resources and Forestry; International Joint Commission; National Oceanic and Atmospheric Administration Great Lakes Environmental Research Laboratory; U.S. Geological Survey; U.S. Fish and Wildlife Services; U.S. Environmental Protection Agency; Environment Canada; Nature Conservancy; Great Lakes Fishery Commission; University of Michigan; Michigan State University; University of Minnesota-Duluth; University of Windsor FX We thank Arthur Cooper for his advice and guidance on catchment and watershed development in the GIS environment. This project was funded by the Great Lakes Fishery Trust and received in kind support from the Michigan Department of Natural Resources, Ontario Ministry of Natural Resources and Forestry; International Joint Commission, National Oceanic and Atmospheric Administration Great Lakes Environmental Research Laboratory, U.S. Geological Survey, U.S. Fish and Wildlife Services, U.S. Environmental Protection Agency, Environment Canada, The Nature Conservancy, the Great Lakes Fishery Commission, University of Michigan, Michigan State University, University of Minnesota-Duluth, and University of Windsor. NR 36 TC 1 Z9 1 U1 5 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-474X EI 1752-1688 J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD OCT PY 2016 VL 52 IS 5 BP 1068 EP 1088 DI 10.1111/1752-1688.12435 PG 21 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA EB2EL UT WOS:000387170400006 ER PT J AU Golden, HE Lane, CR Prues, AG D'Amico, E AF Golden, Heather E. Lane, Charles R. Prues, Amy G. D'Amico, Ellen TI BOOSTED REGRESSION TREE MODELS TO EXPLAIN WATERSHED NUTRIENT CONCENTRATIONS AND BIOLOGICAL CONDITION SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article DE watersheds; watershed management; environmental impacts; nutrients; biotic integrity; boosted regression trees; machine learning ID NONPOINT-SOURCE POLLUTION; LOW-FLOW NITRATE; LAND-USE; BIOTIC INTEGRITY; TOPOGRAPHIC CONTROLS; NITROGEN POLLUTION; HEADWATER STREAMS; PREDICTIVE MODELS; WADEABLE STREAMS; RIPARIAN BUFFERS AB Boosted regression tree (BRT) models were developed to quantify the nonlinear relationships between landscape variables and nutrient concentrations in a mesoscale mixed land cover watershed during base-flow conditions. Factors that affect instream biological components, based on the Index of Biotic Integrity (IBI), were also analyzed. Seasonal BRT models at two spatial scales (watershed and riparian buffered area [RBA]) for nitrite-nitrate (No-2-NO3), total Kjeldahl nitrogen, and total phosphorus (TP) and annual models for the IBI score were developed. Two primary factors - location within the watershed (i.e., geographic position, stream order, and distance to a downstream confluence) and percentage of urban land cover (both scales) - emerged as important predictor variables. Latitude and longitude interacted with other factors to explain the variability in summer NO2-NO3 concentrations and IBI scores. BRT results also suggested that location might be associated with indicators of sources (e.g., land cover), runoff potential (e.g., soil and topographic factors), and processes not easily represented by spatial data indicators. Runoff indicators (e.g., Hydrological Soil Group D and Topographic Wetness Indices) explained a substantial portion of the variability in nutrient concentrations as did point sources for TP in the summer months. The results from our BRT approach can help prioritize areas for nutrient management in mixed-use and heavily impacted watersheds. C1 [Golden, Heather E.; Lane, Charles R.] US EPA, Syst Exposure Div, Natl Exposure Res Lab, Off Res & Dev, 26 W Martin Luther King Dr,MS-585, Cincinnati, OH 45268 USA. [Prues, Amy G.; D'Amico, Ellen] CSS Dynamac Corp, Cincinnati, OH 45268 USA. RP Golden, HE (reprint author), US EPA, Syst Exposure Div, Natl Exposure Res Lab, Off Res & Dev, 26 W Martin Luther King Dr,MS-585, Cincinnati, OH 45268 USA. EM golden.heather@epa.gov NR 93 TC 0 Z9 0 U1 5 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-474X EI 1752-1688 J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD OCT PY 2016 VL 52 IS 5 BP 1251 EP 1274 DI 10.1111/1752-1688.12447 PG 24 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA EB2EL UT WOS:000387170400017 ER PT J AU Burbank, AJ Grabich, SC Todorich, K Frye, M Loughlin, C Duncan, K Robinette, C Mills, K Peden, DB Diaz-Sanchez, D Hernandez, ML AF Burbank, Allison J. Grabich, Shannon C. Todorich, Krista Frye, Marcia Loughlin, Ceila Duncan, Kelly Robinette, Carole Mills, Katherine Peden, David B. Diaz-Sanchez, David Hernandez, Michelle L. TI Effect of aeroallergen sensitization on asthma control in African American teens with persistent asthma SO ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY LA English DT Letter ID CHILDREN; HYPERRESPONSIVENESS; METHACHOLINE C1 [Burbank, Allison J.; Robinette, Carole; Mills, Katherine; Peden, David B.; Hernandez, Michelle L.] Univ N Carolina, Ctr Environm Med Asthma & Lung Biol, Chapel Hill, NC 27514 USA. [Grabich, Shannon C.; Diaz-Sanchez, David] US EPA, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC USA. [Todorich, Krista] Allergy & Asthma Associates Michigan, Royal Oak, MI USA. [Frye, Marcia; Loughlin, Ceila] Univ N Carolina, Dept Pediat, Div Pediat Pulmonol, Chapel Hill, NC USA. [Duncan, Kelly] Merck Pharmaceut, Kenilworth, NJ USA. RP Burbank, AJ (reprint author), Univ N Carolina, Ctr Environm Med Asthma & Lung Biol, Chapel Hill, NC 27514 USA. EM allison.burbank@unchealth.unc.edu NR 9 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1081-1206 EI 1534-4436 J9 ANN ALLERG ASTHMA IM JI Ann. Allergy Asthma Immunol. PD OCT PY 2016 VL 117 IS 4 BP 442 EP 444 PG 4 WC Allergy; Immunology SC Allergy; Immunology GA EA3IU UT WOS:000386496400027 PM 27566861 ER PT J AU Tolaymat, T Abdelraheem, W El Badawy, A Dionysiou, D Genaidy, A AF Tolaymat, Thabet Abdelraheem, Wael El Badawy, Amro Dionysiou, Dionysios Genaidy, Ash TI The path towards healthier societies, environments, and economies: a broader perspective for sustainable engineered nanomaterials SO CLEAN TECHNOLOGIES AND ENVIRONMENTAL POLICY LA English DT Article; Proceedings Paper CT 18th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction (PRES) CY AUG 23-28, 2015 CL Kuching, MALAYSIA DE Sustainable engineered nanomaterials; Physical-chemical properties; Value-added benefits (VAB); Green chemistry and engineering; Cognitive engineering; Society, environment and economy ID SOCIOTECHNICAL DESIGN; SILVER NANOPARTICLES; NANOTECHNOLOGY; PRINCIPLES; HIERARCHY; FRAMEWORK; TOXICITY AB Economic value is no longer adequate by itself as a proxy for the value-added benefits (VAB) assumed to be generated by emerging technologies such as engineered nanomaterials (ENMs). This study was conducted to explore the potential to establish an integrated sociotechnical framework with the end goal to assess whether or not ENMs and nano-enabled products contribute VAB. Based on the research in this study, it is suggested that all stakeholders in the larger society-environment-economy (SEE) system should develop an understanding of the multiple interrelationships within and between the diverse constituents along the particle lifecycle trajectory to capture their influence on the system benefit and risk outcomes. Furthermore, the sociotechnical framework establishes an additional three-step process: (1) at the pre-design stage, the test of VAB should be assessed using an expert panel representing the different segments of SEE, the social principles of design are detailed and customized to the needs of ENMs and nano-enabled products, and an economic appraisal is conducted to justify the VAB on material grounds; (2) at the design stage, the technical principles should be examined and detailed to ensure the compatibility of stakeholder needs; and (3) an iterative adaptive cycle should be conducted to re-examine the sociotechnical principles on a periodic basis. Within this context, ENMs are considered sustainable when (a) the conditions of VAB and minimal risk elements are satisfied in a sequential order, with VAB demonstrated at the pre-design stage, then at the design stage ENMs posing no harm greater than minimal levels to the SEE constituents; and (b) ENMs and nano-enabled products are bounded by a finite time limit. In addition, to reach the conditions of sustainability, the role of all SEE stakeholders should be broadened (e.g., regulatory agencies should transform their roles from not only the control of risks of negative implications, but also the establishment of positive implications as well). C1 [Tolaymat, Thabet] US EPA, Off Res & Dev, Cincinnati, OH 45221 USA. [Abdelraheem, Wael; El Badawy, Amro; Genaidy, Ash] Worldtek Inc, Cincinnati, OH 45249 USA. [Abdelraheem, Wael] Sohag Univ, Dept Chem, Fac Sci, Sohag 82524, Egypt. [Dionysiou, Dionysios] Univ Cincinnati, Sustainable Solut Lab, Dept Biomed Chem & Environm Engn, Cincinnati, OH 45221 USA. RP Tolaymat, T (reprint author), US EPA, Off Res & Dev, Cincinnati, OH 45221 USA. EM tolaymat.thabet@epa.gov OI Abdelraheem, Wael/0000-0003-4390-7756 NR 46 TC 0 Z9 0 U1 3 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1618-954X EI 1618-9558 J9 CLEAN TECHNOL ENVIR JI Clean Technol. Environ. Policy PD OCT PY 2016 VL 18 IS 7 SI SI BP 2279 EP 2291 DI 10.1007/s10098-016-1146-7 PG 13 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental; Environmental Sciences SC Science & Technology - Other Topics; Engineering; Environmental Sciences & Ecology GA EA1PX UT WOS:000386365400024 ER PT J AU Chien, HC Yang, YHK Bai, JPF AF Chien, Hsu-Chih Yang, Yea-Huei Kao Bai, Jane P. F. TI Trastuzumab-Related Cardiotoxic Effects in Taiwanese Women A Nationwide Cohort Study SO JAMA ONCOLOGY LA English DT Article ID BREAST-CANCER PATIENTS; CARDIAC SAFETY ANALYSIS; HEART-FAILURE; ADJUVANT CHEMOTHERAPY; TIME BIAS; FOLLOW-UP; TRIAL; THERAPY; ASIA; DOXORUBICIN AB IMPORTANCE Trastuzumab is an essential medicine per the World Health Organization Model List, but its cardiac safety information in Asian women is limited. OBJECTIVE To estimate the rate and the risk of heart failure (HF) and/or cardiomyopathy (CM) in Asian women undergoing trastuzumab treatment. DESIGN This cohort study used the Taiwanese National Health Insurance Research Database (NHIRD), a nationwide claim database covering more than 99% of the entire Taiwanese population, to identify 23 006 women with incident breast cancer (BC) who received chemotherapy from 2006 to 2009. We grouped women per their initial treatment regimens and found 1066 new trastuzumab users. We matched trastuzumab users with nonusers by year of BC diagnosis and propensity score (PS) with the caliper widths at 0.25 standard deviation of PS (up to 4 nonusers per trastuzumab user). The study lasted from January 2006 to December 2013 with a median follow-up of 5.29 years and a landmark design to avoid immortal time bias. EXPOSURE Trastuzumab. MAIN OUTCOMES AND MEASURES To estimate HF and/or CM rates and time to HF and/or CM, we employed a cause-specific hazard model. Trastuzumab exposure was a time-dependent variable, while cumulative courses of chemotherapy agents with known cardiotoxic effects (including anthracyclines, taxanes, and cyclophosphamide) were defined as time-dependent covariates in the analysis model. We also performed 6 sensitivity analyses. RESULTS In this cohort of 23 006 women (mean age, 50.99 years), the crude incidence of HF and/or CM was 4.03% in trastuzumab users and 2.88% in nonusers. The median time to HF and/or CM was 456 days in trastuzumab users and 966 days in nonusers. The 1-year cumulative hazard ratio was 1.86 (95% CI, 1.08-3.19). The sensitivity analyses yielded similar results. CONCLUSIONS AND RELEVANCE Compared with the published results, the trastuzumab-related HF and/or CM rate was 5-fold lower in Taiwanese women with breast cancer. Nonetheless, our cohort had a similar trastuzumab-related HF and/or CM risk. Our study provides critical cardiac safety information of trastuzumab for Asian women with BC under current treatment guidelines and label information. C1 [Chien, Hsu-Chih; Bai, Jane P. F.] US FDA, Off Clin Pharmacol, Off Translat Sci, Ctr Drug Evaluat & Res, 10903 New Hampshire Ave, Silver Spring, MD 20993 USA. [Chien, Hsu-Chih; Yang, Yea-Huei Kao] Natl Cheng Kung Univ, Coll Med, Inst Clin Pharm & Pharmaceut Sci, 1 Univ Rd, Tainan 70101, Taiwan. [Chien, Hsu-Chih; Yang, Yea-Huei Kao] Natl Cheng Kung Univ, Hlth Outcome Res Ctr, Tainan, Taiwan. RP Yang, YHK (reprint author), Natl Cheng Kung Univ, Coll Med, Inst Clin Pharm & Pharmaceut Sci, 1 Univ Rd, Tainan 70101, Taiwan.; Bai, JPF (reprint author), US EPA, Off Translat Sci, Ctr Drug Evaluat & Res, 10903 New Hampshire Ave, Silver Spring, MD 20993 USA. EM yhkao@mail.ncku.edu.tw; jane.bai@fda.hhs.gov FU Taiwan Ministry of Science and Technology [102-2628-B-006-003-MY3]; FDA CDER [12-30] FX This research was supported by the Taiwan Ministry of Science and Technology (grant No. 102-2628-B-006-003-MY3) and a 2012 Critical Path Award (#12-30) from the FDA CDER. NR 35 TC 1 Z9 1 U1 2 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA EI 2374-2445 J9 JAMA ONCOL JI JAMA Oncol. PD OCT 1 PY 2016 VL 2 IS 10 BP 1317 EP 1325 DI 10.1001/jamaoncol.2016.1269 PG 9 WC Oncology SC Oncology GA EA3GB UT WOS:000386488600016 PM 27310478 ER PT J AU DeFlorio-Barker, S Wade, TJ Turyk, M Dorevitch, S AF DeFlorio-Barker, Stephanie Wade, Timothy J. Turyk, Mary Dorevitch, Samuel TI Water recreation and illness severity SO JOURNAL OF WATER AND HEALTH LA English DT Article DE fecal indicator bacteria; gastrointestinal illness; illness severity; water recreation ID RAPIDLY MEASURED INDICATORS; UNITED-STATES; QUALITY; HEALTH AB The health endpoint of prior studies of water recreation has been the occurrence of gastrointestinal (GI) illness. This dichotomous measure fails to take into account the range of symptom severity among those with GI illness, and those who develop GI symptoms but who do not satisfy the definition of GI illness. Data from two US cohort studies were used to assess use of ordinal and semi-continuous measures of GI symptoms, such as duration of GI symptoms and responses to those symptoms such as medication use, interference with daily activities, and utilization of healthcare service. Zero-inflated negative binomial and logistic regression models were used to assess associations between severity and either the degree of water exposure or water quality. Among 37,404 water recreators without baseline GI symptoms, we observed individuals with relatively low severity satisfying the case definition of GI illness, while others with high severity not satisfying that definition. Severity metrics were associated with water exposure. The dichotomous GI illness outcome could be improved by considering symptom severity in future studies. Modeling ordinal and semi-continuous outcomes may improve our understanding of determinants of the burden of illness rather than simply the number of cases of illness attributable to environmental exposures. C1 [DeFlorio-Barker, Stephanie; Dorevitch, Samuel] Univ Illinois, Sch Publ Hlth, Div Environm & Occupat Hlth Sci, Chicago, IL USA. [Wade, Timothy J.] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Turyk, Mary] Univ Illinois, Sch Publ Hlth, Div Epidemiol & Biostat, Chicago, IL USA. RP DeFlorio-Barker, S (reprint author), Univ Illinois, Sch Publ Hlth, Div Environm & Occupat Hlth Sci, Chicago, IL USA. EM sdeflor2@uic.edu FU Metropolitan Water Reclamation District of Greater Chicago; Water Environment Research Foundation; US Environmental Protection Agency (US EPA) STAR [RD-83478901] FX For the CHEERS study: This research was funded by the Metropolitan Water Reclamation District of Greater Chicago. A peer review panel for this study was supported by the Water Environment Research Foundation. Support for analyses of water quality measures as environmental public health indicators was provided by US Environmental Protection Agency (US EPA) STAR agreement RD-83478901. The contents of this work on CHEERS are solely the responsibility of the grantee and do not necessarily represent the official views of the EPA. Further, the EPA does not endorse the purchase of any commercial products or services mentioned herein. NR 36 TC 0 Z9 0 U1 2 U2 2 PU IWA PUBLISHING PI LONDON PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND SN 1477-8920 J9 J WATER HEALTH JI J. Water Health PD OCT PY 2016 VL 14 IS 5 BP 713 EP 726 DI 10.2166/wh.2016.002 PG 14 WC Environmental Sciences; Public, Environmental & Occupational Health; Microbiology; Water Resources SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Microbiology; Water Resources GA EA5XU UT WOS:000386699300001 PM 27740539 ER PT J AU Pierson, JC Coates, DJ Oostermeijer, JGB Beissinger, SR Bragg, JG Sunnucks, P Schumaker, NH Young, AG AF Pierson, Jennifer C. Coates, David J. Oostermeijer, J. Gerard B. Beissinger, Steven R. Bragg, Jason G. Sunnucks, Paul Schumaker, Nathan H. Young, Andrew G. TI Genetic factors in threatened species recovery plans on three continents SO FRONTIERS IN ECOLOGY AND THE ENVIRONMENT LA English DT Review ID WILD POPULATIONS; CONSERVATION; GENOMICS; EXTINCTION; MANAGEMENT; ACT; DEPRESSION; BENEFITS; FITNESS; RESCUE AB Around the world, recovery planning for threatened species is being applied in an attempt to stem the current extinction crisis. Genetic factors linked to small population processes (eg inbreeding, loss of genetic diversity) play a key role in species viability. We examined how often genetic factors are considered in threatened species recovery planning. We selected recent species recovery plans from Europe (n = 110), North America (the US only; n = 100), and Australia (n = 108), and reviewed three broad categories of genetic data they address: population-genetic, fitness-related, and life-history data. We found that the host country, taxonomic group to which the species belonged, and several proposed management actions were important predictors of the inclusion of genetic factors. Notably, species recovery plans from the US were more likely to include genetic issues, probably due to legislative requirements. We recommend an international standard, similar to an IUCN Red List framework, that requires explicit consideration of genetic aspects of long-term viability. C1 [Pierson, Jennifer C.; Young, Andrew G.] Commonwealth Sci & Ind Res Org CSIRO Plant Ind, Canberra, ACT, Australia. [Pierson, Jennifer C.] Australian Natl Univ, Fenner Sch Environm & Soc, Canberra, ACT, Australia. [Coates, David J.] Dept Pk & Wildlife, Sci & Conservat Div, Perth, WA, Australia. [Oostermeijer, J. Gerard B.] Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, Amsterdam, Netherlands. [Beissinger, Steven R.] Univ Calif Berkeley, Dept Environm Sci Policy & Management, Berkeley, CA 94720 USA. [Bragg, Jason G.] Australian Natl Univ, Res Sch Biol, Canberra, ACT, Australia. [Sunnucks, Paul] Monash Univ, Sch Biol Sci, Melbourne, Vic, Australia. [Schumaker, Nathan H.] US EPA, Western Ecol Div, Corvallis, OR USA. RP Pierson, JC (reprint author), Commonwealth Sci & Ind Res Org CSIRO Plant Ind, Canberra, ACT, Australia.; Pierson, JC (reprint author), Australian Natl Univ, Fenner Sch Environm & Soc, Canberra, ACT, Australia. EM jennifer.pierson@anu.edu.au RI Bragg, Jason/R-5611-2016; OI Bragg, Jason/0000-0002-7621-7295; Sunnucks, Paul/0000-0002-8139-7059 FU Australian Centre for Ecological Analysis and Synthesis; CSIRO; Western Australian Department of Conservation; US Environmental Protection Agency (EPA) FX The Australian Centre for Ecological Analysis and Synthesis, CSIRO, and the Western Australian Department of Conservation provided support for this research. Assistance with plan reviews was provided by T Pleines (US plans), S Luijten and Y Hartman (European plans), and S McArthur (Australian plans). We thank A Mortelliti and M Westgate for data analysis and visualization assistance. The US Environmental Protection Agency (EPA) funded NHS and approved this paper for publication; approval does not imply the content reflects the views of EPA. NR 35 TC 0 Z9 0 U1 22 U2 22 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1540-9295 EI 1540-9309 J9 FRONT ECOL ENVIRON JI Front. Ecol. Environ. PD OCT PY 2016 VL 14 IS 8 BP 433 EP 440 DI 10.1002/fee.1323 PG 8 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA DZ8MD UT WOS:000386123600014 ER PT J AU Spisni, E Seo, S Joo, SH Su, C AF Spisni, E. Seo, S. Joo, S. H. Su, C. TI Release and toxicity comparison between industrial- and sunscreen-derived nano-ZnO particles SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY LA English DT Article DE Aggregation; Commercial ZnO; Ecotoxicity; Sunscreen ZnO; Thalassiosira pseudonana ID ZINC-OXIDE NANOPARTICLES; DIATOM THALASSIOSIRA-PSEUDONANA; ENGINEERED NANOMATERIALS; ENVIRONMENT; EXPOSURE; STRESS; HAZARD AB Many consumer products containing ZnO have raised concern for safety in regard to environmental impact and the public health. Widely used sunscreens for protecting against UV and avoiding sunburns represent a great exposure to nano-ZnO, one of the ingredients commonly applied in sunscreens. Applying nanoproducts on beaches may release nanoparticles unintentionally into the ocean. Despite the accumulation of such nanoproducts in the ocean harming or being detrimental to critical marine organisms, few studies have investigated the release and potential toxicity of nanoparticles extracted from products and compared them with those from industrial-type nanoparticles. Results show that the cytotoxicity of both industrial-and sunscreen-derived nano-ZnO to the marine diatom algae, Thalassiosira pseudonana, increased as exposure increases over time, as measured by growth inhibition (%) of the algae at a constant concentration of nano-ZnO (10 mg/L). The extent of toxicity appeared to be higher from industrial- type nano-ZnO compared with sunscreen-extracted nano-ZnO, though the extent becomes similar when concentrations increase to 50 mg/L. On the other hand, at a fixed exposure time of 48 h, the cytotoxicity increases as concentrations increase with the higher toxicity shown from the industrial-type compared with sunscreen-induced nano-ZnO. Results indicate that while industrial-type nano-ZnO shows higher toxicity than sunscreen-derived nano-ZnO, the release and extent of toxicity from nano-ZnO extracted from sunscreen are not trivial and should be monitored for the development of safe manufacturing of nanomaterials-induced products. C1 [Spisni, E.; Seo, S.; Joo, S. H.] Univ Miami, Dept Civil Architectural & Environm Engn, 1251 Mem Dr McArthur Engn Bldg, Coral Gables, FL 33146 USA. [Su, C.] US Environm Protect Agcy, Ground Water & Ecosyst Restorat Div, Natl Risk Management, Res Lab,Off Res & Dev, 919 Kerr Res Dr, Ada, OK 74820 USA. RP Joo, SH (reprint author), Univ Miami, Dept Civil Architectural & Environm Engn, 1251 Mem Dr McArthur Engn Bldg, Coral Gables, FL 33146 USA. EM s.joo1@miami.edu NR 30 TC 0 Z9 0 U1 15 U2 15 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1735-1472 EI 1735-2630 J9 INT J ENVIRON SCI TE JI Int. J. Environ. Sci. Technol. PD OCT PY 2016 VL 13 IS 10 BP 2485 EP 2494 DI 10.1007/s13762-016-1077-1 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA DZ8MZ UT WOS:000386125800017 ER PT J AU Makris, SL Scott, CS Fox, J Knudsen, TB Hotchkiss, AK Arzuaga, X Euling, SY Powers, CM Jinot, J Hogan, KA Abbott, BD Hunter, ES Narotsky, MG AF Makris, Susan L. Scott, Cheryl Siegel Fox, John Knudsen, Thomas B. Hotchkiss, Andrew K. Arzuaga, Xabier Euling, Susan Y. Powers, Christina M. Jinot, Jennifer Hogan, Karen A. Abbott, Barbara D. Hunter, E. Sidney, III Narotsky, Michael G. TI A systematic evaluation of the potential effects of trichloroethylene exposure on cardiac development SO REPRODUCTIVE TOXICOLOGY LA English DT Review DE Trichloroethylene; TCE; Cardiac; Malformations; AOP AB The 2011 EPA trichloroethylene (TCE) IRIS assessment, used developmental cardiac defects from a controversial drinking water study in rats (Johnson et al. [51]), along with several other studies/endpoints to derive reference values. An updated literature search of TCE-related developmental cardiac defects was conducted. Study quality, strengths, and limitations were assessed. A putative adverse outcome pathway (ADP). construct was developed to explore key events for the most commonly observed cardiac dysmorphologies, particularly those involved with epithelial-mesenchymal transition (EMT) of endothelial origin (EndMT); several candidate pathways were identified. A hypothesis-driven weight-of-evidence analysis of epidemiological, toxicological, in vitro, in ovo, and mechanistic/AOP data concluded that TCE has the potential to cause cardiac defects in humans when exposure occurs at sufficient doses during a sensitive window of fetal development. The study by Johnson et al. [51] was reaffirmed as suitable for hazard characterization and reference value derivation, though acknowledging study limitations and uncertainties. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). C1 [Makris, Susan L.; Scott, Cheryl Siegel; Fox, John; Arzuaga, Xabier; Euling, Susan Y.; Jinot, Jennifer; Hogan, Karen A.] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Washington, DC 20460 USA. [Hotchkiss, Andrew K.] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA. [Abbott, Barbara D.; Hunter, E. Sidney, III; Narotsky, Michael G.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Knudsen, Thomas B.] US EPA, Off Res & Dev, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA. [Powers, Christina M.] US EPA, Off Transportat & Air Qual, Assessment & Stand Div, Ann Arbor, MI 48105 USA. RP Makris, SL (reprint author), US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Washington, DC 20460 USA. EM makris.susan@epa.gov NR 93 TC 0 Z9 0 U1 4 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0890-6238 J9 REPROD TOXICOL JI Reprod. Toxicol. PD OCT PY 2016 VL 65 BP 321 EP 358 DI 10.1016/j.reprotox.2016.08.014 PG 38 WC Reproductive Biology; Toxicology SC Reproductive Biology; Toxicology GA DZ6RZ UT WOS:000385990900035 PM 27575429 ER PT J AU Wegner, S Browne, P Dix, D AF Wegner, Susanna Browne, Patience Dix, David TI Identifying reference chemicals for thyroid bioactivity screening SO REPRODUCTIVE TOXICOLOGY LA English DT Article DE Reference chemicals; Thyroid; Performance-based validation; Amphibian metamorphosis assay; Rat pubertal assay AB Reference chemicals were selected based on thyroid bioactivity in 'Tier 1' screening assays used by the U.S. EPA's Endocrine Disruptor Screening Program. Active reference chemicals had significant effects on thyroid-responsive endpoints in the amphibian metamorphosis assay, and the male and female pubertal rat assays. In the absence of thyroid weight or histopathological effects, additional published studies providing mechanistic data on thyroid activity were required for active chemicals. Inactive reference chemicals had no significant effects on thyroid-responsive endpoints in Tier 1 assays, or in amphibian or rodent studies from several online databases. The 34 reference chemicals (29 active and five inactive) will be useful for performance-based validation of alternative, high throughput screening assays for thyroid bioactivity. (C) 2016 Published by Elsevier Inc. C1 [Wegner, Susanna] Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37830 USA. [Browne, Patience; Dix, David] US EPA, Off Sci Coordinat & Policy, Off Chem Safety & Pollut Prevent, Washington, DC 20460 USA. RP Wegner, S (reprint author), Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37830 USA. EM shwegner@uw.edu NR 95 TC 0 Z9 0 U1 4 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0890-6238 J9 REPROD TOXICOL JI Reprod. Toxicol. PD OCT PY 2016 VL 65 BP 402 EP 413 DI 10.1016/j.reprotox.2016.08.016 PG 12 WC Reproductive Biology; Toxicology SC Reproductive Biology; Toxicology GA DZ6RZ UT WOS:000385990900041 PM 27589887 ER PT J AU Duvall, RM Long, RW Beaver, MR Kronmiller, KG Wheeler, ML Szykman, JJ AF Duvall, Rachelle M. Long, Russell W. Beaver, Melinda R. Kronmiller, Keith G. Wheeler, Michael L. Szykman, James J. TI Performance Evaluation and Community Application of Low-Cost Sensors for Ozone and Nitrogen Dioxide SO SENSORS LA English DT Article DE nitrogen dioxide; ozone; low-cost sensors; electrochemical sensor; performance evaluation; citizen science ID AIR-QUALITY; GAS SENSORS; CALIBRATION; POLLUTION AB This study reports on the performance of electrochemical-based low-cost sensors and their use in a community application. CairClip sensors were collocated with federal reference and equivalent methods and operated in a network of sites by citizen scientists (community members) in Houston, Texas and Denver, Colorado, under the umbrella of the NASA-led DISCOVER-AQ Earth Venture Mission. Measurements were focused on ozone (O-3) and nitrogen dioxide (NO2). The performance evaluation showed that the CairClip O-3/NO2 sensor provided a consistent measurement response to that of reference monitors (r(2) = 0.79 in Houston; r(2) = 0.72 in Denver) whereas the CairClip NO2 sensor measurements showed no agreement to reference measurements. The CairClip O-3/NO2 sensor data from the citizen science sites compared favorably to measurements at nearby reference monitoring sites. This study provides important information on data quality from low-cost sensor technologies and is one of few studies that reports sensor data collected directly by citizen scientists. C1 [Duvall, Rachelle M.; Long, Russell W.; Szykman, James J.] US EPA, Off Res & Dev, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. [Beaver, Melinda R.] US EPA, Off Air Qual Planning & Stand, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. [Kronmiller, Keith G.; Wheeler, Michael L.] Jacobs Technol Inc, 600 William Northern Blvd, Tullahoma, TN 37388 USA. [Szykman, James J.] NASA Langley Res Ctr, 11 Langley Blvd, Hampton, VA 23681 USA. RP Duvall, RM (reprint author), US EPA, Off Res & Dev, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM duvall.rachelle@epa.gov; long.russell@epa.gov; beaver.melinda@epa.gov; kronmiller.keith@epa.gov; wheeler.michael@epa.gov; james.j.szykman@nasa.gov NR 19 TC 0 Z9 0 U1 17 U2 17 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 1424-8220 J9 SENSORS-BASEL JI Sensors PD OCT PY 2016 VL 16 IS 10 AR 1698 DI 10.3390/s16101698 PG 14 WC Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation SC Chemistry; Electrochemistry; Instruments & Instrumentation GA DZ8OY UT WOS:000386131600150 ER PT J AU Biales, AD Kostich, MS Batt, AL See, MJ Flick, RW Gordon, DA Lazorchak, JM Bencic, DC AF Biales, Adam D. Kostich, Mitchell S. Batt, Angela L. See, Mary J. Flick, Robert W. Gordon, Denise A. Lazorchak, Jim M. Bencic, David C. TI Initial development of a multigene 'omics-based exposure biomarker for pyrethroid pesticides SO AQUATIC TOXICOLOGY LA English DT Article DE Pyrethroids; Gene expression; Microarray; Fish; Aquatic ID LARGE GENE LISTS; FATHEAD MINNOWS; TOXICITY; IDENTIFICATION; ECOTOXICOLOGY; ESFENVALERATE; SENSITIVITY; MODEL; WATER AB Omics technologies have long since promised to address a number of long standing issues related to environmental regulation. Despite considerable resource investment, there are few examples where these tools have been adopted by the regulatory community, which is in part due to a focus of most studies on discovery rather than assay development. The current work describes the initial development of an omics based assay using 48 h Pimephales promelas (FHM) larvae for identifying aquatic exposures to pyrethroid pesticides. Larval FHM were exposed to seven concentrations of each of four pyrethroids (permethrin, cypermethrin, esfenvalerate and bifenthrin) in order to establish dose response curves. Then, in three separate identical experiments, FHM were exposed to a single equitoxic concentration of each pyrethroid, corresponding to 33% of the calculated LC50. All exposures were separated by weeks and all materials were either cleaned or replaced between runs in an attempt to maintain independence among exposure experiments. Gene expression classifiers were developed using the random forest algorithm for each exposure and evaluated first by cross-validation using hold out organisms from the same exposure experiment and then against test sets of each pyrethroid from separate exposure experiments. Bifenthrin exposed organisms generated the highest quality classifier, demonstrating an empirical Area Under the Curve (eAUC) of 0.97 when tested against bifenthrin exposed organisms from other exposure experiments and 0.91 against organisms exposed to any of the pyrethroids. An eAUC of 1.0 represents perfect classification with no false positives or negatives. Additionally, the bifenthrin classifier was able to successfully classify organisms from all other pyrethroid exposures at multiple concentrations, suggesting a potential utility for detecting cumulative exposures. Considerable run-to-run variability was observed both in exposure concentrations and molecular responses of exposed fish across exposure experiments. The application of a calibration step in analysis successfully corrected this, resulting in a significantly improved classifier. Classifier evaluation suggested the importance of considering a number of aspects of experimental design when developing an expression based tool for general use in ecological monitoring and risk assessment, such as the inclusion of multiple experimental runs and high replicate numbers. Published by Elsevier B.V. C1 [Biales, Adam D.; Kostich, Mitchell S.; Batt, Angela L.; See, Mary J.; Flick, Robert W.; Gordon, Denise A.; Lazorchak, Jim M.; Bencic, David C.] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. RP Biales, AD (reprint author), US EPA, MS 591, Cincinnati, OH 45268 USA. EM abiales@hotmail.com OI Lazorchak, James/0000-0002-7354-7571; Biales, Adam/0000-0003-2323-6721 NR 35 TC 0 Z9 0 U1 10 U2 10 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-445X EI 1879-1514 J9 AQUAT TOXICOL JI Aquat. Toxicol. PD OCT PY 2016 VL 179 BP 27 EP 35 DI 10.1016/j.aquatox.2016.08.004 PG 9 WC Marine & Freshwater Biology; Toxicology SC Marine & Freshwater Biology; Toxicology GA DZ1KS UT WOS:000385597900004 PM 27564377 ER PT J AU Ghio, AJ AF Ghio, Andrew J. TI Asthma as a disruption in iron homeostasis SO BIOMETALS LA English DT Article DE Asthma; Iron; Ferritin; Inflammation ID ACUTE-PHASE RESPONSE; LOW-BIRTH-WEIGHT; PULMONARY ARTERIAL-HYPERTENSION; EXERCISE-INDUCED BRONCHOCONSTRICTION; RESPIRATORY-DISTRESS-SYNDROME; RESTLESS LEGS SYNDROME; SICKLE-CELL-DISEASE; INCREASED BRONCHIAL RESPONSIVENESS; INFLAMMATORY-BOWEL-DISEASE; ISOLATED RABBIT MYOCARDIUM AB Over several decades, asthma has evolved from being recognized as a single disease to include a diverse group of phenotypes with dissimilar natural histories, pathophysiologies, responses to treatment, and distinctive molecular pathways. With the application of Occam's razor to asthma, it is proposed that there is one cause underlying the numerous phenotypes of this disease and that the responsible molecular pathway is a deficiency of iron in the lung tissues. This deficiency can be either absolute (e.g. asthma in the neonate and during both pregnancy and menstruation) or functional (e.g. asthma associated with infections, smoking, and obesity). Comparable associations between asthma co-morbidity (e.g. eczema, urticaria, restless leg syndrome, and pulmonary hypertension) with iron deficiency support such a shared mechanistic pathway. Therapies directed at asthma demonstrate a capacity to impact iron homeostasis, further strengthening the relationship. Finally, pathophysiologic events producing asthma, including inflammation, increases in Th2 cells, and muscle contraction, can correlate with iron availability. Recognition of a potential association between asthma and an absolute and/or functional iron deficiency suggests specific therapeutic interventions including inhaled iron. C1 [Ghio, Andrew J.] US EPA, Chapel Hill, NC 27599 USA. [Ghio, Andrew J.] Human Studies Facil, 104 Mason Farm Rd, Chapel Hill, NC 27599 USA. RP Ghio, AJ (reprint author), Human Studies Facil, 104 Mason Farm Rd, Chapel Hill, NC 27599 USA. EM ghio.andy@epa.gov NR 378 TC 0 Z9 0 U1 4 U2 4 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0966-0844 EI 1572-8773 J9 BIOMETALS JI Biometals PD OCT PY 2016 VL 29 IS 5 BP 751 EP 779 DI 10.1007/s10534-016-9948-y PG 29 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA DY6QI UT WOS:000385252400001 PM 27595579 ER PT J AU Maher, WA Duncan, E Dilly, G Foster, S Krikowa, F Lombi, E Scheckel, K Girguis, P AF Maher, W. A. Duncan, E. Dilly, G. Foster, S. Krikowa, F. Lombi, E. Scheckel, K. Girguis, P. TI Arsenic concentrations and species in three hydrothermal vent worms, Ridgeia piscesae, Paralvinella sulficola and Paralvinella palmiformis SO DEEP-SEA RESEARCH PART I-OCEANOGRAPHIC RESEARCH PAPERS LA English DT Article ID MARINE FOOD-CHAINS; HPLC-ICP-MS; BIOLOGICAL TISSUES; SPECIATION; ARSENOBETAINE; DEGRADATION; MICROORGANISMS; ORGANISMS; SPECTROMETRY; EXTRACTION AB Hydrothermal vents are surficial expressions of subsurface geological and hydrological processes. Fluids emitting from active vents are chemically distinct from bottom seawater, and are enriched in dissolved metals and metalloids, including arsenic. Vent organisms accumulate arsenic but the arsenic speciation in these non-photosynthetic organisms is largely unknown. Here, arsenic concentrations and chemical species were measured in three deep sea hydrothermal vent worms (Ridgeia piscesae, Paralvinella sulfincola and Paralvinella palmiformis) from the Juan de Fuca Ridge in the Northwest pacific. R. piscesae has similar arsenic concentrations (3.8-35 mu g g(-1)) to shallow water polychaetes while P. sulfincola and P. palmiformis have significantly higher arsenic concentrations (420-1417 and 125-321 mu g g(-1) respectively). R. piscesae contains appreciable quantities of inorganic arsenic (36 +/- 14%), monomethyl arsenic (2 +/- 2%), dimethyl arsenic (34 +/- 21%), an unknown methyl arsenical (7 +/- 16%), OSO3-arsenosugar (5 +/- 9%), TETRA (4 +/- 5%), ThioPO(4)/ThioDMAE (1 +/- 2%) and an unknown thio-arsenical (12 +/- 14%). These results suggests that host and symbionts are either involved in the methylation of arsenic, or are bathed in fluids enriched in methylated arsenic as a result of free-living microbial activity. The host carrying out methylation, however, cannot be ruled out. In contrast, 96-97% of the arsenic in P. sulfincola and P. palmiformis is inorganic arsenic, likely the result of arsenic precipitation within and upon the mucus they ingest while feeding. While all worms have oxo- and thio arsenosugars (2-30%), Paralvinella also have small amounts of arsenobetaine (< 0.001-0.21%). The presence of arsenosugars, arsenobetaine and other minor arsenic species in the absence of photosynthesising algae/bacteria indicates that they may be formed by vent animals in the absence of sunlight, but at this time their formation cannot be explained. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Maher, W. A.; Foster, S.; Krikowa, F.] Univ Canberra, Inst Appl Ecol, Ecochem Lab, Bruce 2601, Australia. [Duncan, E.; Lombi, E.] Univ South Australia, Future Ind Inst, Mawson Lakes, SA 5095, Australia. [Dilly, G.; Girguis, P.] Harvard Univ, Dept Organism & Evolutionary Biol OEB, Cambridge, MA 02138 USA. [Scheckel, K.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Maher, WA (reprint author), Univ Canberra, Inst Appl Ecol, Ecochem Lab, Bruce 2601, Australia. EM bill.maher@canberra.edu.au RI BM, MRCAT/G-7576-2011; OI Scheckel, Kirk/0000-0001-9326-9241; Foster, Simon/0000-0002-9136-3215 NR 44 TC 0 Z9 0 U1 12 U2 12 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0967-0637 EI 1879-0119 J9 DEEP-SEA RES PT I JI Deep-Sea Res. Part I-Oceanogr. Res. Pap. PD OCT PY 2016 VL 116 BP 41 EP 48 DI 10.1016/j.dsr.2016.07.009 PG 8 WC Oceanography SC Oceanography GA DY7RJ UT WOS:000385326700005 ER PT J AU Weber, MA Meixner, T Stromberg, JC AF Weber, Matthew A. Meixner, Thomas Stromberg, Juliet C. TI Valuing instream-related services of wastewater SO ECOSYSTEM SERVICES LA English DT Article DE Instream flow; Riparian area; Swimmable water quality; Generalized mixed logit; Wastewater; Effluent ID WILLINGNESS-TO-PAY; ECOSYSTEM SERVICES; CHOICE EXPERIMENTS; QUALITY; MARINE; MODEL; IMPROVEMENTS; METAANALYSIS; RECREATION; STREAMFLOW AB In the southwestern US water resources are increasingly scarce, leaving perennial habitats and associated environmental amenities vulnerable to off-channel water demands. To provide management insight, the value of two instream flow related ecosystem services are estimated for two river reaches, for two separate population centers. The specific services are preservation of instream flow extent and accompanying Cottonwood-Willow riparian forest, and improving water quality to be safe for full body recreational contact. The case study is of a highly modified effluent-dominated waterway, yet strong support for maintaining wet river habitat was documented, apparently due mainly to ecological rather than recreational motivations. In general, the more distant river reach with more trees was more highly valued on a per mile basis, and the population center closest to both river reaches more highly valued their preservation. Support was mixed for increasing water treatment to allow safe full body contact. Well-known multinomial and mixed logit models are compared with a relatively new generalized mixed logit framework, with the latter performing best. Documentation of public values associated with the posed river management options assist decision-making for the case study and similar contexts lacking quantification of the value of instream flow related ecosystem services. (C) 2016 Elsevier B.V. All rights reserved. C1 [Weber, Matthew A.] US EPA, Western Ecol Div, 200 SW 35th St, Corvallis, OR 97333 USA. [Meixner, Thomas] Univ Arizona, Dept Hydrol & Water Resources, 1133 E James E Rogers Way, Tucson, AZ 85721 USA. [Stromberg, Juliet C.] Arizona State Univ, Sch Life Sci, 427 E Tyler Mall, Tempe, AZ 85281 USA. RP Weber, MA (reprint author), US EPA, Western Ecol Div, 200 SW 35th St, Corvallis, OR 97333 USA. EM weber.matthew@cpa.gov; tmeixner@email.arizona.edu; jstrom@asu.edu FU US Environmental Protection Agency; National Science Foundation, DEB Grant [1038938] FX The lead author would like to thank postdoctoral funding through the US Environmental Protection Agency for supporting this research. The second and third authors would like to thank the National Science Foundation, DEB Grant #1038938. The authors are grateful for the comments and/or assistance of three anonymous reviewers, as well as the following persons: E. Brott; E. Canfield; E. Curley; C. Cvitanovich; J. Fonseca; J. Hoehn; E. Holler; H. Huth; R. Johnston; M. Massey; R. Niraula; P. Ringold; V.K. Smith; M.H. Weber, M. White; C. Zugmeyer; and of course all of the survey pretesters and respondents who took the time to submit their opinion and preference. Persons named above do not necessarily endorse the manuscript. All errors and faults remain with the authors. NR 47 TC 0 Z9 0 U1 3 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 2212-0416 J9 ECOSYST SERV JI Ecosyst. Serv. PD OCT PY 2016 VL 21 BP 59 EP 71 DI 10.1016/j.ecoser.2016.07.016 PN A PG 13 WC Ecology; Environmental Sciences; Environmental Studies SC Environmental Sciences & Ecology GA DZ0KC UT WOS:000385526300007 ER PT J AU Hu, XDC Andrews, DQ Lindstrom, AB Bruton, TA Schaider, LA Grandjean, P Lohmann, R Carignan, CC Blum, A Balan, SA Higgins, CP Sunderland, EM AF Hu, Xindi C. Andrews, David Q. Lindstrom, Andrew B. Bruton, Thomas A. Schaider, Laurel A. Grandjean, Philippe Lohmann, Rainer Carignan, Courtney C. Blum, Arlene Balan, Simona A. Higgins, Christopher P. Sunderland, Elsie M. TI Detection of Poly- and Perfluoroalkyl Substances (PFASs) in US Drinking Water Linked to Industrial Sites, Military Fire Training Areas, and Wastewater Treatment Plants SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS LA English DT Article ID PERFLUOROOCTANOIC ACID PFOA; POLYFLUOROALKYL SUBSTANCES; PERFLUORINATED COMPOUNDS; SERUM CONCENTRATIONS; LANDFILL LEACHATES; HUMAN EXPOSURE; CONTAMINATION; BIOSOLIDS; CHILDREN; FATE AB Drinking water contamination with poly- and perfluoroalkyl substances (PFASs) poses risks to the developmental, immune, metabolic, and endocrine health of consumers. We present a spatial analysis of 2013-2015 national drinking water PFAS concentrations from the U.S. Environmental Protection Agency's (US EPA) third Unregulated Contaminant Monitoring Rule (UCMR3) program. The number of industrial sites that manufacture or use these compounds, the number of military fire training areas, and the number of wastewater treatment plants are all significant predictors of PFAS detection frequencies and concentrations in public water supplies. Among samples with detectable PFAS levels, each additional military site within a watershed's eight digit hydrologic unit is associated with a 20% increase in PFHxS, a 10% increase in both PFHpA and PFOA, and a 35% increase in PFOS. The number of civilian airports with personnel trained in the use of aqueous film -forming foams is significantly associated with the detection of PFASs above the minimal reporting level. We find drinking water supplies for 6 million U.S. residents exceed US EPA's lifetime health advisory (70 ng/L) for PFOS and PFOA. Lower analytical reporting limits and additional sampling of smaller utilities serving <10000 individuals and private wells would greatly assist in further identifying PFAS contamination sources. C1 [Hu, Xindi C.; Grandjean, Philippe; Carignan, Courtney C.; Sunderland, Elsie M.] Harvard TH Chan Sch Publ Hlth, Boston, MA 02215 USA. [Hu, Xindi C.; Sunderland, Elsie M.] Harvard John A Paulson Sch Engn & Appl Sci, Cambridge, MA 02138 USA. [Andrews, David Q.] Environm Working Grp, Washington, DC 20009 USA. [Lindstrom, Andrew B.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Bruton, Thomas A.; Blum, Arlene] Univ Calif Berkeley, Berkeley, CA 94720 USA. [Schaider, Laurel A.] Silent Spring Inst, Newton, MA 02460 USA. [Lohmann, Rainer] Univ Rhode Isl, Narragansett, RI 02882 USA. [Blum, Arlene; Balan, Simona A.] Green Sci Policy Inst, Berkeley, CA 94705 USA. [Balan, Simona A.] Calif Dept Tox Subst Control, 1001 1 St, Sacramento, CA 95814 USA. [Higgins, Christopher P.] Colorado Sch Mines, 1500 Illinois St, Golden, CO 80401 USA. RP Hu, XDC (reprint author), Harvard Univ, 128 Pierce Hall, Cambridge, MA 02138 USA. EM xhu@mail.harvard.edu RI Sunderland, Elsie/D-5511-2014; Bruton, Thomas/D-1738-2012; OI Sunderland, Elsie/0000-0003-0386-9548; Bruton, Thomas/0000-0002-4090-6021; Lohmann, Rainer/0000-0001-8796-3229; Grandjean, Philippe/0000-0003-4046-9658 FU Smith Family Foundation; U.S. National Institute for Environmental Health Sciences (NIEHS) Superfund Research Program [P42 ES004705]; Superfund Research Center at the University of California, Berkeley FX We acknowledge financial support for research at Harvard from the Smith Family Foundation and a private donor. We thank Marcia Castro (Harvard) for her feedback on an earlier version of the manuscript and Jahred Liddie (Harvard) for his assistance with the sensitivity analysis. T.A.B. was supported by the U.S. National Institute for Environmental Health Sciences (NIEHS) Superfund Research Program (Grant P42 ES004705) and the Superfund Research Center at the University of California, Berkeley. The views expressed in this article are those of the authors and do not necessarily represent the views or policies of the U.S. Environmental Protection Agency. NR 61 TC 10 Z9 10 U1 57 U2 57 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2328-8930 J9 ENVIRON SCI TECH LET JI Environ. Sci. Technol. Lett. PD OCT PY 2016 VL 3 IS 10 BP 344 EP 350 DI 10.1021/acs.estlett.6b00260 PG 7 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA DY7WL UT WOS:000385339900001 PM 27752509 ER PT J AU Bowler, RM Adams, SW Wright, CW Kim, Y Booty, A Colledge, M Gocheva, VV Lobdell, DT AF Bowler, Rosemarie M. Adams, Shane W. Wright, Chris W. Kim, Yangho Booty, Andrew Colledge, Michelle Gocheva, Vihra V. Lobdell, Danelle T. TI Medication use associated with exposure to manganese in two Ohio towns SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH LA English DT Article DE Air; heavy metals; illness; pollution; communities ID GASTROESOPHAGEAL-REFLUX DISEASE; UNITED-STATES; INDUCED PARKINSONISM; GENERAL-POPULATION; AIRBORNE MANGANESE; BLOOD-PRESSURE; COMMUNITY; PREVALENCE; ACCURACY; HEALTH AB This report describes the use of medications as a proxy when medical record reviews are unavailable, to study the health effects of residents environmentally exposed to air-manganese (n=185) compared to unexposed residents (n=90). Participants' current medication lists and medication questionnaire responses were collected in clinical interviews and categorized into 13 domains. Exposed participants reported fewer hours of sleep than controls (6.6 vs. 7.0). The exposed used significantly more medications than unexposed participants (82.2% vs. 67.8%) and, when adjusting for age, education, and personal income, also for pain (aOR=2.40) and hypothyroidism (aOR=7.03). Exposed participants with higher air-Mn concentrations, monitored for 10years by the U.S. Environmental Protection Agency, were 1.5 times more likely to take pain medications. The exposed participants take significantly more medications than unexposed participants in the categories of hypothyroidism, pain, supplements, and total medications. C1 [Bowler, Rosemarie M.; Adams, Shane W.; Wright, Chris W.; Gocheva, Vihra V.] San Francisco State Univ, Dept Psychol, San Francisco, CA 94132 USA. [Kim, Yangho] Univ Ulsan, Coll Med, Dept Occupat & Environm Med, Ulsan Univ Hosp, Ulsan, South Korea. [Booty, Andrew] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA. [Colledge, Michelle] ATSDR, Chicago, IL USA. [Lobdell, Danelle T.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. RP Bowler, RM (reprint author), San Francisco State Univ, Dept Psychol, San Francisco, CA 94132 USA. EM rbowl@sfsu.edu FU US Environmental Protection Agency [83416001]; US EPA [EP-11-D-000424, EP-13-D-000146] FX This work was supported by the US Environmental Protection Agency [cooperative agreement number 83416001] to San Francisco State University and US EPA Contracts [EP-11-D-000424] and [EP-13-D-000146]. NR 52 TC 0 Z9 0 U1 3 U2 3 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 0960-3123 EI 1369-1619 J9 INT J ENVIRON HEAL R JI Int. J. Environ. Health Res. PD OCT-DEC PY 2016 VL 26 IS 5-6 BP 483 EP 496 DI 10.1080/09603123.2016.1194381 PG 14 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA DY9ES UT WOS:000385437100002 PM 27295281 ER PT J AU Buck, KD AF Buck, Kyle D. TI Modelling of geographic cancer risk factor disparities in US counties SO APPLIED GEOGRAPHY LA English DT Article DE Cancer; Mortality to incidence ratio; Geographically weighted regression; Social; Economic; Index ID TO-INCIDENCE RATIOS; ENVIRONMENTAL HAZARDS; RACIAL DISPARITIES; UNITED-STATES; VULNERABILITY; MORTALITY; DIAGNOSIS; SURVIVAL; SYSTEM; STAGE AB The goal of this research is to create a theoretical framework for the identification of cancer risk factor disparities and address the recognition of geographic patterns in these factors. 34 secondary variables covering the entire US at the county level in 2010 were analyzed, both individually and grouped (theoretically and statistically), in relation to the mortality to incidence ratio (MIR) for all cancer sites. An a priori assessment and a principal components analysis (PCA) were used to group variables to test societal constructs. OLS and geographically weighted regressions (GWRs) were used to assess influence of both individual and grouped variables against the MIR The theoretical grouping of variables showed little change in predictive capability of OLS models. In GWR model, there was marked improvement over the OLS. Maps produced using local R2 showed clear regional patterns of influence between the indicators and the MIR. Both the theoretical model and the justification for a spatial approach to cancer risk factor disparities were shown to be effective in this paper. The link between this suite of indicators and the health outcomes is clear, and supports the idea that a full representation of the SES landscape should be used to both predict health outcomes and to assess policy options for improving these outcomes. With the presence of definitive regional patterns and clear connections between the MIR and societal groupings, the findings from this research suggest a need to shift to a more comprehensive and spatial approach to cancer disparities research. Published by Elsevier Ltd. C1 [Buck, Kyle D.] US EPA, ORD, NHEERL, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA. RP Buck, KD (reprint author), US EPA, ORD, NHEERL, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA. EM buck.kyle@epa.gov RI , Kyle/L-6011-2016 OI , Kyle/0000-0001-8955-8200 NR 30 TC 0 Z9 0 U1 7 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0143-6228 EI 1873-7730 J9 APPL GEOGR JI Appl. Geogr. PD OCT PY 2016 VL 75 BP 28 EP 35 DI 10.1016/j.apgeog.2016.08.001 PG 8 WC Geography SC Geography GA DY1SE UT WOS:000384873900003 ER PT J AU Schmeltz, MT Marcotullio, PJ Himmelstein, DU Woolhandler, S Sembajwe, G AF Schmeltz, Michael T. Marcotullio, Peter J. Himmelstein, David U. Woolhandler, Steffie Sembajwe, Grace TI Outcomes of hospitalizations for common illnesses associated with a comorbid heat-related illness in the United States, 2001-2010 SO CLIMATIC CHANGE LA English DT Article DE Climate change; Heat-related illness; Temperature; Heat; Respiratory health ID CLIMATE-CHANGE IMPACTS; AIR-POLLUTION; MORTALITY; HEALTH; WAVES; TEMPERATURE; ADMISSIONS; RISK; HEATSTROKE; MORBIDITY AB This research examines whether inpatients with common illnesses and comorbid heat-related illness (HRI) suffer worse health outcomes and use more hospital resources than similar patients without a diagnosed HRI. We used the Nationwide Inpatient Sample, 2001-2010 to compare outcomes, including inpatient length of stay, number of procedures, total charges, discharge status and death, for hospitalization of common illnesses with and without HRI. We used bivariate and multivariable regressions to identify risk factors for health outcomes among inpatients with common illnesses and comorbid HRI. Stratified analyses examined outcomes according to sociodemographics and hospital characteristics to further identify specific risk factors. Among inpatients with respiratory illnesses, negative outcomes were more frequent when a comorbid HRI was present. Additionally, inpatients with cardiac diseases showed increased mortality when a comorbid HRI was present. Overall, comorbid HRI was not associated with worse outcomes among the other common illnesses analyzed. While heat may precipitate hospital admissions for renal and diabetic conditions, these conditions have similar outcomes whether or not a HRI is present. However, comorbid HRI is associated with worse outcomes for respiratory illness hospitalizations and higher risk of death among cardiac disease hospitalizations. C1 [Schmeltz, Michael T.] US EPA, ASPPH EPA Environm Hlth Fellowship Program, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA. [Schmeltz, Michael T.; Himmelstein, David U.; Woolhandler, Steffie; Sembajwe, Grace] CUNY, Sch Publ Hlth, New York, NY 10021 USA. [Marcotullio, Peter J.; Himmelstein, David U.; Woolhandler, Steffie; Sembajwe, Grace] CUNY Hunter Coll, New York, NY 10021 USA. [Marcotullio, Peter J.] CUNY, Inst Sustainable Cities, New York, NY 10021 USA. RP Schmeltz, MT (reprint author), US EPA, ASPPH EPA Environm Hlth Fellowship Program, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA.; Schmeltz, MT (reprint author), CUNY, Sch Publ Hlth, New York, NY 10021 USA. EM mschmeltz@gradcenter.cuny.edu FU ASPPH or EPA FX M.S. is a participant in the ASPPH/EPA Environmental Health Fellowship (Class of 2015). However, the work conducted for this publication was completed prior to the fellowship and has no relationship to the fellowship whatsoever and was not funded by ASPPH or EPA. NR 47 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0165-0009 EI 1573-1480 J9 CLIMATIC CHANGE JI Clim. Change PD OCT PY 2016 VL 138 IS 3-4 BP 567 EP 584 DI 10.1007/s10584-016-1747-5 PG 18 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA DW4LS UT WOS:000383615200015 ER PT J AU Aguirre, AA Beasley, VR Augspurger, T Benson, WH Whaley, J Basu, N AF Aguirre, A. Alonso Beasley, Val R. Augspurger, Tom Benson, William H. Whaley, Janet Basu, Niladri TI One healthTransdisciplinary opportunities for SETAC leadership in integrating and improving the health of people, animals, and the environment SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Editorial Material DE Animal; Ecotoxicology; One Health; Human health; Public health; Ecosystem; Review; Institutions ID ECOSYSTEMS; WILDLIFE; DISEASE AB One Health is a collaborative, transdisciplinary effort working locally, nationally, and globally to improve health for people, animals, plants, and the environment. The term is relatively new (from approximate to 2003), and it is increasingly common to see One Health included by name in interinstitutional research partnerships, conferences, communications, and organizational frameworks, particularly those championed by the human health and veterinary medical communities. Environmental quality is arguably the least developed component within the One Health framework, but can be guided by expertise within the Society of Environmental Toxicology and Chemistry (SETAC). Despite SETAC's long history of tripartite (academic, government, business) interdisciplinary environmental science activities, the term One Health is seldom used in SETAC communications (i.e., many of SETAC's activities are guided by One Health, but it is called by other names in SETAC's journals, newsletters, and presentations). Accordingly, the objective of this Focus article is to introduce the One Health concept to the SETAC membership. The article discusses the origins, evolution, and utility of the One Health approach as an organizational framework and provides key examples of ways in which SETAC expertise can benefit the One Health community. The authors assert that One Health needs SETAC and, to be most effective, SETAC needs One Health. Given that One Health to date has focused too little on the environment, on ecosystems, and on contaminants, SETAC's constructive involvement in One Health presents an opportunity to accelerate actions that will ultimately better protect human and ecosystem health. Environ Toxicol Chem 2016;35:2383-2391. (c) 2016 SETAC C1 [Aguirre, A. Alonso] George Mason Univ, Dept Environm Sci & Policy, Fairfax, VA 22030 USA. [Beasley, Val R.] Penn State Univ, Dept Vet & Biomed Sci, University Pk, PA 16802 USA. [Augspurger, Tom] US Fish & Wildlife Serv, Ecol Serv, Raleigh, NC USA. [Benson, William H.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Whaley, Janet] Exponent, Ecol & Biol Sci Practice, Alexandria, VA USA. [Basu, Niladri] McGill Univ, Fac Agr & Environm Sci, Montreal, PQ, Canada. RP Aguirre, AA (reprint author), George Mason Univ, Dept Environm Sci & Policy, Fairfax, VA 22030 USA. EM aaguirr3@gmu.edu OI Basu, Niladri/0000-0002-2695-1037 NR 29 TC 1 Z9 1 U1 6 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD OCT PY 2016 VL 35 IS 10 BP 2383 EP 2391 DI 10.1002/etc.3557 PG 9 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DY0UD UT WOS:000384810800001 PM 27717067 ER PT J AU Davis, JM Ekman, DR Teng, Q Ankley, GT Berninger, JP Cavallin, JE Jensen, KM Kahl, MD Schroeder, AL Villeneuve, DL Jorgenson, ZG Lee, KE Collette, TW AF Davis, John M. Ekman, Drew R. Teng, Quincy Ankley, Gerald T. Berninger, Jason P. Cavallin, Jenna E. Jensen, Kathleen M. Kahl, Michael D. Schroeder, Anthony L. Villeneuve, Daniel L. Jorgenson, Zachary G. Lee, Kathy E. Collette, Timothy W. TI Linking field-based metabolomics and chemical analyses to prioritize contaminants of emerging concern in the Great Lakes basin SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Metabolomics; Fathead minnow; Contaminant; Screening; Great Lakes ID MINNOWS PIMEPHALES-PROMELAS; WASTE-WATER; AQUATIC ENVIRONMENT; SURFACE WATERS; IN-VITRO; PHARMACEUTICALS; METABOLITES; BIOMARKERS; RESPONSES; EXPOSURE AB The ability to focus on the most biologically relevant contaminants affecting aquatic ecosystems can be challenging because toxicity-assessment programs have not kept pace with the growing number of contaminants requiring testing. Because it has proven effective at assessing the biological impacts of potentially toxic contaminants, profiling of endogenous metabolites (metabolomics) may help screen out contaminants with a lower likelihood of eliciting biological impacts, thereby prioritizing the most biologically important contaminants. The authors present results from a study that utilized cage-deployed fathead minnows (Pimephales promelas) at 18 sites across the Great Lakes basin. They measured water temperature and contaminant concentrations in water samples (132 contaminants targeted, 86 detected) and used H-1-nuclear magnetic resonance spectroscopy to measure endogenous metabolites in polar extracts of livers. They used partial least-squares regression to compare relative abundances of endogenous metabolites with contaminant concentrations and temperature. The results indicated that profiles of endogenous polar metabolites covaried with at most 49 contaminants. The authors identified up to 52% of detected contaminants as not significantly covarying with changes in endogenous metabolites, suggesting they likely were not eliciting measurable impacts at these sites. This represents a first step in screening for the biological relevance of detected contaminants by shortening lists of contaminants potentially affecting these sites. Such information may allow risk assessors to prioritize contaminants and focus toxicity testing on the most biologically relevant contaminants. Environ Toxicol Chem 2016;35:2493-2502. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US Government work and, as such, is in the public domain in the United States of America. C1 [Davis, John M.; Ekman, Drew R.; Teng, Quincy; Collette, Timothy W.] US EPA, Natl Exposure Res Lab, Athens, GA USA. [Ankley, Gerald T.; Berninger, Jason P.; Cavallin, Jenna E.; Jensen, Kathleen M.; Kahl, Michael D.; Schroeder, Anthony L.; Villeneuve, Daniel L.] US EPA, Natl Hlth & Environm Effects Res Lab, Duluth, MN USA. [Jorgenson, Zachary G.] US Fish & Wildlife Serv, Ecol Serv, Bloomington, MN USA. [Lee, Kathy E.] US Geol Survey, Minnesota Water Sci Ctr, Grand Rapids, MI USA. RP Davis, JM; Collette, TW (reprint author), US EPA, Natl Exposure Res Lab, Athens, GA USA. EM Davis.John@epa.gov; Collette.Tim@epa.gov FU Great Lakes National Program Office; US Department of Energy; USEPA; Oak Ridge Institute for Science and Education fellowship FX We thank J. Banda, S. Choy, E. Durhan, D. Gefell, C. LaLone, S. Langer, E. Makynen, M. Menheer, J. Moore, M. Pearson, M. Severson, and K. Stevens for technical assistance and T. Smith for research support. M. Berntsson and L. Eriksson (Umetrics) and S. Wenger provided guidance on statistical analyses. J.M. Davis was supported by the Great Lakes National Program Office and an appointment to the Postdoctoral Research Program at the National Exposure Research Laboratory, administered by Oak Ridge Institute for Science and Education through interagency agreement between the US Department of Energy and the USEPA. J.E. Cavallin was supported by an Oak Ridge Institute for Science and Education fellowship. NR 44 TC 1 Z9 1 U1 16 U2 16 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD OCT PY 2016 VL 35 IS 10 BP 2493 EP 2502 DI 10.1002/etc.3409 PG 10 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DY0UD UT WOS:000384810800016 PM 27027868 ER PT J AU Meier, HCS Haan, MN de Leon, CFM Simanek, AM Dowd, JB Aiello, AE AF Meier, Helen C. S. Haan, Mary N. de Leon, Carlos F. Mendes Simanek, Amanda M. Dowd, Jennifer B. Aiello, Allison E. TI Early life socioeconomic position and immune response to persistent. infections among elderly Latinos SO SOCIAL SCIENCE & MEDICINE LA English DT Article DE Socioeconomic position; Persistent infections; Life course epidemiology; Latino health ID HELICOBACTER-PYLORI INFECTION; SYSTEMIC-LUPUS-ERYTHEMATOSUS; UNITED-STATES; CYTOMEGALOVIRUS-INFECTION; AUTOIMMUNE-DISEASES; TOXOPLASMA-GONDII; ANTIBODY-TITERS; SEROPREVALENCE; CHILDHOOD; US AB Persistent infections, such as cytomegalovirus (CMV), herpes simplex virus-1 (HSV-1), Helicobacter pylori (H. pylori), and Toxoplasma gondii (T. gondii), are common in the U.S. but their prevalence varies by socioeconomic status, It is unclear if early or later life socioeconomic position (SEP) is a more salient driver of disparities in immune control of these infections. Using data from the Sacramento Area Latino Study on Aging, we examined whether early or later life SEP was the strongest predictor of immune control later in life by contrasting two life course models, the critical period model and the chain of risk model. Early life SEP was measured as a latent variable, derived from parental education and occupation, and food availability. Indicators for SEP in later life included education level and occupation. Individuals were categorized by immune response to each pathogen (seronegative, low, medium and high) with increasing immune response representing poorer immune control. Cumulative immune response was estimated using a latent profile analysis with higher total immune response representing poorer immune control. Structural equation models were used to examine direct, indirect and total effects of early life SEP on each infection and cumulative immune response, controlling for age and gender. The direct effect of early life SEP on immune response was not statistically significant for the infections or cumulative immune response. Higher early life SEP was associated with lower immune response for T gondii, H. pylori and cumulative immune response through pathways mediated by later life SEP. For CMV, higher early life SEP was both directly associated and partially mediated by later life SEP. No association was found between SEP and HSV-1. Findings from this study support a chain of risk model, whereby early life SEP acts through later life SEP to affect immune response to persistent infections in older age. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Meier, Helen C. S.] Natl Inst Environm Hlth Sci, Epidemiol Branch, 171 TW Alexander Dr,POB 12233,MD A3-05, Res Triangle Pk, NC 27709 USA. [Haan, Mary N.] Univ Calif San Francisco, Dept Epidemiol & Biostat, 550 15th St, San Francisco, CA 94158 USA. [de Leon, Carlos F. Mendes] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ctr Social Epidemiol & Populat Hlth, 1415 Washington Hts, Ann Arbor, MI 48109 USA. [Simanek, Amanda M.] Univ Wisconsin, Joseph J Zilber Sch Publ Hlth, POB 413, Milwaukee, WI 53201 USA. [Dowd, Jennifer B.] CUNY, Hunter Coll, CUNY Sch Publ Hlth, Dept Epidemiol & Biostat, 2180 Third Ave, New York, NY 10035 USA. [Aiello, Allison E.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, 135 Dauer Dr 2101B McGavran Greenberg Hall, Chapel Hill, NC 27599 USA. RP Aiello, AE (reprint author), Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, 135 Dauer Dr 2101B McGavran Greenberg Hall, Chapel Hill, NC 27599 USA. EM helen.meier@nih.gov; mary.haan@ucsf.edu; cmendes@umich.edu; simaneka@uwm.edu; jdowd@hunter.cuny.edu; aaiello@email.unc.edu OI Meier, Helen/0000-0003-4400-0216; Dowd, Jennifer/0000-0003-2006-5656 FU National Institute on Aging, National Institutes of Health [R01AG012975]; Intramural Research Program of the NIH, National Institute of Environmental Health Sciences; [P60MD002249]; [R01DA022702]; [R01DK087864] FX Funding for the SALSA study was aided by a grant from the National Institute on Aging, National Institutes of Health: R01AG012975. Additional support for this work from grants: P60MD002249, R01DA022702, and R01DK087864. We thank Brisa Sanchez for her statistical consultation and the Stanley Neurovirology Laboratory at Johns Hopkins University, particularly Drs. Robert Yolken and Fuller Torrey, for performing the laboratory assays. This research was supported in part by the Intramural Research Program of the NIH, National Institute of Environmental Health Sciences. NR 62 TC 0 Z9 0 U1 9 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0277-9536 J9 SOC SCI MED JI Soc. Sci. Med. PD OCT PY 2016 VL 166 BP 77 EP 85 DI 10.1016/j.socscimed.2016.07.004 PG 9 WC Public, Environmental & Occupational Health; Social Sciences, Biomedical SC Public, Environmental & Occupational Health; Biomedical Social Sciences GA DY0LL UT WOS:000384788200010 PM 27543684 ER PT J AU Eisenberg, JNS Bartram, J Wade, TJ AF Eisenberg, Joseph N. S. Bartram, Jamie Wade, Timothy J. TI The Water Quality in Rio Highlights the Global Public Health Concern Over Untreated Sewage SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article ID INDICATORS; SANITATION; PATHOGENS; BACTERIA; PROGRESS; BRAZIL AB Water quality issues in Rio have been widely publicized because of the 2016 Olympics. Recent concerns about polluted waters that athletes may be exposed to highlights the conditions that more than a billion people globally are exposed to daily. Despite these unhealthy conditions, much is unknown about the risks and exposure pathways associated with bathing in or drinking untreated or partially treated sewage. Beyond acute illness, we are learning more about the chronic sequelae that arise from repeated exposure to pathogens found in sewage. Additionally, we do not know enough about how to measure water quality, especially in developing countries. A consequence of these knowledge gaps is that data from developed countries are used to guide public health approaches in low- and middle-income settings. More data that are locally specific are needed to inform guidelines for improving sanitation and water quality in Rio and other cities in developing countries. C1 [Eisenberg, Joseph N. S.] Univ Michigan, Dept Epidemiol, 1415 Washington Hts, Ann Arbor, MI 48109 USA. [Bartram, Jamie] Univ North Carolina Chapel Hill, Dept Environm Sci & Engn, Water Inst, Chapel Hill, NC USA. [Wade, Timothy J.] US EPA, Chapel Hill, NC USA. RP Eisenberg, JNS (reprint author), Univ Michigan, Dept Epidemiol, 1415 Washington Hts, Ann Arbor, MI 48109 USA. EM jnse@umich.edu NR 16 TC 0 Z9 0 U1 7 U2 7 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD OCT PY 2016 VL 124 IS 10 BP A180 EP A181 DI 10.1289/EHP662 PG 2 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA DX4EQ UT WOS:000384334400003 PM 27689546 ER PT J AU Howie, SRC Schellenberg, J Chimah, O Ideh, RC Ebruke, BE Oluwalana, C Mackenzie, G Jallow, M Njie, M Donkor, S Dionisio, KL Goldberg, G Fornace, K Bottomley, C Hill, PC Grant, CC Corrah, T Prentice, AM Ezzati, M Greenwood, BM Smith, PG Adegbola, RA Mulholland, K AF Howie, S. R. C. Schellenberg, J. Chimah, O. Ideh, R. C. Ebruke, B. E. Oluwalana, C. Mackenzie, G. Jallow, M. Njie, M. Donkor, S. Dionisio, K. L. Goldberg, G. Fornace, K. Bottomley, C. Hill, P. C. Grant, C. C. Corrah, T. Prentice, A. M. Ezzati, M. Greenwood, B. M. Smith, P. G. Adegbola, R. A. Mulholland, K. TI Childhood pneumonia and crowding, bed-sharing and nutrition: a case-control study from The Gambia SO INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE LA English DT Article DE Africa; risk factors; cough; household air pollution; particulate matter ID RISK-FACTORS; BIOMASS FUELS; CHILDREN; INTERVENTIONS; MORTALITY; EXPOSURE; INFANTS; AFRICA; BRAZIL; AREA AB SETTING: Greater Banjul and Upper River Regions, The Gambia. OBJECTIVE: To investigate tractable social, environmental and nutritional risk factors for childhood pneumonia. DESIGN: A case-control study examining the association of crowding, household air pollution (HAP) and nutritional factors with pneumonia was undertaken in children aged 2-59 months: 458 children with severe pneumonia, defined according to the modified WHO criteria, were compared with 322 children with non severe pneumonia, and these groups were compared to 801 neighbourhood controls. Controls were matched by age, sex, area and season. RESULTS: Strong evidence was found of an association between bed-sharing with someone with a cough and SUMMARY severe pneumonia (adjusted OR [aOR] 5.1, 95%CI 3.2-8.2, P < 0.001) and non-severe pneumonia (aOR 7.3, 95%CI 4.1-13.1, P < 0.001), with 18% of severe cases estimated to be attributable to this risk factor. Malnutrition and pneumonia had clear evidence of association, which was strongest between severe malnutrition and severe pneumonia (aOR 8.7, 95%CI 4.2-17.8, P < 0.001). No association was found between pneumonia and individual carbon monoxide exposure as a measure of HAP. CONCLUSION: Bed-sharing with someone with a cough is an important risk factor for severe pneumonia, and potentially tractable to intervention, while malnutrition remains an important tractable determinant. C1 [Howie, S. R. C.; Chimah, O.; Ideh, R. C.; Ebruke, B. E.; Oluwalana, C.; Mackenzie, G.; Donkor, S.; Fornace, K.; Corrah, T.; Prentice, A. M.; Adegbola, R. A.] MRC Unit, Fajara, Gambia. [Howie, S. R. C.; Grant, C. C.] Univ Auckland, Dept Paediat Child & Youth Hlth, Auckland, New Zealand. [Howie, S. R. C.; Hill, P. C.] Univ Otago, Ctr Int Hlth, Dunedin, New Zealand. [Schellenberg, J.; Fornace, K.; Bottomley, C.; Prentice, A. M.; Greenwood, B. M.; Smith, P. G.; Mulholland, K.] London Sch Hyg & Trop Med, London, England. [Ideh, R. C.] Univ Benin, Teaching Hosp, Dept Child Hlth, Benin, Nigeria. [Jallow, M.; Njie, M.] Minist Hlth & Social Welf, Banjul, Gambia. [Dionisio, K. L.] Harvard Sch Publ Hlth, Dept Global Hlth & Populat, Boston, MA USA. [Dionisio, K. L.] Harvard Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA. [Dionisio, K. L.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Ezzati, M.] Med Res Council MRC Human Nutr Res, Cambridge, England. [Goldberg, G.] Imperial Coll London, MRC Publ Hlth England Ctr Environm & Hlth, London, England. [Ezzati, M.] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England. [Adegbola, R. A.] GlaxoSmithKline Vaccines, Wavre, Belgium. [Mulholland, K.] Univ Melbourne, Parkville, NSW, Australia. RP Howie, SRC (reprint author), MRC Unit, POB 273, Banjul, Gambia.; Howie, SRC (reprint author), Univ Auckland, Dept Paediat, Auckland, New Zealand. EM stephen.howie@auckland.ac.nz OI Grant, Cameron/0000-0002-4032-7230 FU Medical Research Council [MC_U123292701, MC_U190088484, MC_UP_A900_1116, MC_UP_A900_1124] NR 39 TC 0 Z9 0 U1 3 U2 3 PU INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) PI PARIS PA 68 BOULEVARD SAINT-MICHEL,, 75006 PARIS, FRANCE SN 1027-3719 EI 1815-7920 J9 INT J TUBERC LUNG D JI Int. J. Tuberc. Lung Dis. PD OCT PY 2016 VL 20 IS 10 BP 1405 EP 1415 DI 10.5588/ijtld.15.0993 PG 11 WC Infectious Diseases; Respiratory System SC Infectious Diseases; Respiratory System GA DX5AZ UT WOS:000384393500026 PM 27725055 ER PT J AU Leal, CG Pompeu, PS Gardner, TA Leito, RP Hughes, RM Kaufmann, PR Zuanon, J de Paula, FR Ferraz, SFB Thomson, JR Mac Nally, R Ferreira, J Barlow, J AF Leal, Cecilia G. Pompeu, Paulo S. Gardner, Toby A. Leito, Rafael P. Hughes, Robert M. Kaufmann, Philip R. Zuanon, Jansen de Paula, Felipe R. Ferraz, Silvio F. B. Thomson, James R. Mac Nally, Ralph Ferreira, Joice Barlow, Jos TI Multi-scale assessment of human-induced changes to Amazonian instream habitats SO LANDSCAPE ECOLOGY LA English DT Article DE Anthropogenic impacts; Physical and chemical habitat; Random forest models; Watershed management; Deforestation; Land use change; Freshwater; Amazon basin; Tropical forest ID FISH ASSEMBLAGE STRUCTURE; LAND-USE; STREAM ECOSYSTEMS; BRAZILIAN AMAZON; SOUTHEASTERN BRAZIL; PHYSICAL HABITAT; RIPARIAN FOREST; BED STABILITY; HUMAN IMPACTS; DEFORESTATION AB Land use change and forest degradation have myriad effects on tropical ecosystems. Yet their consequences for low-order streams remain very poorly understood, including in the worldA ' s largest freshwater basin, the Amazon. Determine the degree to which physical and chemical characteristics of the instream habitat of low-order Amazonian streams change in response to past local- and catchment-level anthropogenic disturbances. To do so, we collected field instream habitat (i.e., physical habitat and water quality) and landscape data from 99 stream sites in two eastern Brazilian Amazon regions. We used random forest regression trees to assess the relative importance of different predictor variables in determining changes in instream habitat response variables. Multiple drivers, operating at multiple spatial scales, were important in determining changes in the physical habitat and water quality of the sites. Although we found few similarities in modelled relationships between the two regions, we observed non-linear responses of specific instream characteristics to landscape change; for example 20 % of catchment deforestation resulted in consistently warmer streams. Our results highlight the importance of local riparian and catchment-scale forest cover in shaping instream physical environments, but also underscore the importance of other land use changes and activities, such as road crossings and upstream agriculture intensification. In contrast to the property-scale focus of the Brazilian Forest code, which governs environmental regulations on private land, our results reinforce the importance of catchment-wide management strategies to protect stream ecosystem integrity. C1 [Leal, Cecilia G.; Pompeu, Paulo S.] Univ Fed Lavras, Fish Ecol Lab, BR-37200000 Lavras, MG, Brazil. [Leal, Cecilia G.; Barlow, Jos] Univ Lancaster, Lancaster Environm Ctr, Lancaster LA1 4YW, England. [Leal, Cecilia G.; Barlow, Jos] Museu Paraense Emilio Goeldi, BR-66040170 Belem, PA, Brazil. [Gardner, Toby A.] Stockholm Environm Inst, S-10451 Stockholm, Sweden. [Leito, Rafael P.; Zuanon, Jansen] Natl Inst Amazonia Res, BR-69060001 Manaus, AM, Brazil. [Hughes, Robert M.] Oregon State Univ, Amnis Opes Inst, Corvallis, OR 97701 USA. [Hughes, Robert M.] Oregon State Univ, Dept Fisheries & Wildlife, Corvallis, OR 97701 USA. [Kaufmann, Philip R.] US EPA, Off Res & Dev, Corvallis, OR 97333 USA. [de Paula, Felipe R.; Ferraz, Silvio F. B.] Univ Sao Paulo, Luiz de Queiroz Coll Agr, Forest Hydrol Lab LHF, BR-13418900 Piracicaba, SP, Brazil. [Thomson, James R.; Mac Nally, Ralph] Univ Canberra, Inst Appl Ecol, Bruce, ACT 2617, Australia. RP Leal, CG (reprint author), Univ Fed Lavras, Fish Ecol Lab, BR-37200000 Lavras, MG, Brazil.; Leal, CG (reprint author), Univ Lancaster, Lancaster Environm Ctr, Lancaster LA1 4YW, England.; Leal, CG (reprint author), Museu Paraense Emilio Goeldi, BR-66040170 Belem, PA, Brazil. EM c.gontijoleal@gmail.com RI Pompeu, Paulo/F-6696-2012; Ferraz, Silvio/C-8851-2012; Barlow, Jos/E-7861-2014; OI Ferraz, Silvio/0000-0003-1808-5420; Mac Nally, Ralph/0000-0002-4473-1636 FU Instituto Nacional de Ciencia e Tecnologia-Biodiversidade e Uso da Terra na Amazonia (CNPq) [574008/2008-0]; Empresa Brasileira de Pesquisa Agropecuaria (Embrapa) [SEG: 02.08.06.005.00]; UK government Darwin Initiative [17-023]; Nature Conservancy, Natural Environment Research Council (NERC) [NE/F01614X/1, NE/G000816/1]; Fulbright Brasil; Coordenacao de Aperfeicoamento de Pessoal de Nivel Superiror (CAPES) scholarship in Brazil; Science without Borders Grant in the United Kingdom [PDSE-2943/13-1]; CNPq [304002/2014-3, 156915/2011-1, 400640/2012-0]; FAPEMIG [PPM-00608/15]; CAPES Science Without Borders Grant in France [PDSE-1914/13-8] FX We dedicate this paper to Manoel Nascimento (aka "Nego'') for his invaluable work as a field technician and naturalist. We thank Ceceo Chaves, Debora de Carvalho, Douglas Bastos, Elbin da Silva, Francisco Cunha ("Pita''), Janaina de Brito, Jose Max de Oliveira-Silva, Karina Silva, Leandro Brasil, Leandro Juen, Lenise Flores, Lucas Pires, Marcos Vinicius da Silva, Martinez de Oliveira, Miriam de Almeida, Rafael Duarte, Renilson de Freitas ("Graveto''), Tulio Franco, Valderir Nascimento, and Vivian de Oliveira for their assistance in the field work and the farmers and workers unions of Santarem, Belterra, and Paragominas and all collaborating private landowners for their support. We are also grateful for financial support from Instituto Nacional de Ciencia e Tecnologia-Biodiversidade e Uso da Terra na Amazonia (CNPq; 574008/2008-0), Empresa Brasileira de Pesquisa Agropecuaria (Embrapa; SEG: 02.08.06.005.00), the UK government Darwin Initiative (17-023), The Nature Conservancy, Natural Environment Research Council (NERC; NE/F01614X/1 and NE/G000816/1), and Fulbright Brasil. Individual funding included a Coordenacao de Aperfeicoamento de Pessoal de Nivel Superiror (CAPES) scholarship in Brazil and a Science without Borders Grant in the United Kingdom (PDSE-2943/13-1) to CGL; a CNPq (304002/2014-3) and a FAPEMIG (PPM-00608/15) research fellowship to PSP; CNPq (#156915/2011-1) and CAPES Science Without Borders Grant in France (PDSE-1914/13-8) to RPL, and a CNPq Award (400640/2012-0) to JB. Our manuscript benefitted greatly from reviews by Dr. Peter Saly, Dr. Ryan Hill, and two anonymous reviewers. It was subjected to review by the U.S. Environmental Protection Agency National Health and Environmental Effects Research Laboratory's Western Ecology Division and approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. This paper is #47 in the Sustainable Amazon Network (http://www.redeamazoniasustentavel.org/) and #43 in Projeto Igarapes (http://www.igarapes.bio.br) publication series. NR 102 TC 2 Z9 2 U1 31 U2 31 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0921-2973 EI 1572-9761 J9 LANDSCAPE ECOL JI Landsc. Ecol. PD OCT PY 2016 VL 31 IS 8 BP 1725 EP 1745 DI 10.1007/s10980-016-0358-x PG 21 WC Ecology; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA DV4PD UT WOS:000382906600007 ER PT J AU Forthun, I Wilcox, AJ Strandberg-Larsen, K Moster, D Nohr, EA Lie, RT Suren, P Tollanes, MC AF Forthun, Ingeborg Wilcox, Allen J. Strandberg-Larsen, Katrine Moster, Dag Nohr, Ellen A. Lie, Rolv Terje Suren, Pal Tollanes, Mette C. TI Maternal Prepregnancy BMI and Risk of Cerebral Palsy in Offspring SO PEDIATRICS LA English DT Article ID AUTISM SPECTRUM DISORDERS; MEDICAL BIRTH REGISTRY; FOLIC-ACID SUPPLEMENTS; OBESITY; COHORT; CHILDREN; SURVEILLANCE; INFLAMMATION; METAANALYSIS; PREVALENCE AB OBJECTIVES: To investigate the association between maternal pre-pregnancy BMI and risk of cerebral palsy (CP) in offspring. METHODS: The study population consisted of 188 788 children in the Mothers and Babies in Norway and Denmark CP study, using data from 2 population-based, prospective birth cohorts: the Norwegian Mother and Child Cohort Study and the Danish National Birth Cohort. Prepregnancy BMI was classified as underweight (BMI <18.5), lower normal weight (BMI 18.5-22.9), upper normal weight (BMI 23.0-24.9), overweight (BMI 25.0-29.9), and obese (BMI >= 30). CP diagnoses were obtained from the national CP registries. Associations between maternal prepregnancy BMI and CP in offspring were investigated by using log-binomial regression models. RESULTS: The 2 cohorts had 390 eligible cases of CP (2.1 per 1000 live-born children). Compared with mothers in the lower normal weight group, mothers in the upper normal group had a 40% excess risk of having a child with CP (relative risk [RR], 1.35; 95% confidence interval [CI], 1.03-1.78). Excess risk was 60% (RR, 1.56; 95% CI, 1.21-2.01) for overweight mothers and 60% (RR, 1.55; 95% CI 1.11-2.18) for obese mothers. The risk of CP increased similar to 4% for each unit increase in BMI (RR, 1.04; 95% CI, 1.02-1.06). Estimates changed little with adjustment for mother's occupational status, age, and smoking habits. CONCLUSIONS: Higher prepregnancy maternal BMI was associated with increased risk of CP in offspring. C1 [Forthun, Ingeborg; Moster, Dag; Lie, Rolv Terje; Tollanes, Mette C.] Univ Bergen, Dept Global Publ Hlth & Primary Care, PB 7804, N-5020 Bergen, Norway. [Forthun, Ingeborg; Moster, Dag] Haukeland Hosp, Dept Pediat, Bergen, Norway. [Wilcox, Allen J.] Natl Inst Environm Hlth Sci, Epidemiol Branch, NIH, Durham, NC USA. [Strandberg-Larsen, Katrine] Univ Copenhagen, Dept Publ Hlth, Sect Social Med, Copenhagen, Denmark. [Moster, Dag; Suren, Pal; Tollanes, Mette C.] Norwegian Inst Publ Hlth, Oslo, Norway. [Nohr, Ellen A.] Univ Southern Denmark, Inst Clin Res, Res Unit Gynaecol & Obstet, Odense, Denmark. RP Forthun, I (reprint author), Univ Bergen, Dept Global Publ Hlth & Primary Care, PB 7804, N-5020 Bergen, Norway. EM ingeborg.forthun@uib.no OI Wilcox, Allen/0000-0002-3376-1311 FU Norwegian Ministry of Health; Norwegian Ministry of Education and Research; National Institutes of Health (NIH)/National Institute of Environmental Health Sciences [N01-ES-75558]; NIH/National Institute of Neurological Disorders and Stroke [U01 NS 047537-01, U01 NS 047537-06A1]; Pharmacy Foundation; Egmont Foundation; March of Dimes Birth Defects Foundation; Augustinus Foundation; Health Foundation; Western Norwegian Regional Health Authority; Intramural Research Program at the National Institute of Environmental Health Sciences, NIH; Norwegian Institute of Public Health; University of Copenhagen; Aarhus University; National Institutes of Health (NIH) FX The Norwegian Mother and Child Cohort Study is supported by the Norwegian Ministry of Health and the Ministry of Education and Research, the National Institutes of Health (NIH)/National Institute of Environmental Health Sciences (contract N01-ES-75558), NIH/National Institute of Neurological Disorders and Stroke (grants U01 NS 047537-01 and U01 NS 047537-06A1). The Danish National Research Foundation has established the Danish Epidemiology Science Centre that initiated and created the Danish National Birth Cohort. The cohort is furthermore a result of a major grant from this foundation. Additional support for the Danish National Birth Cohort is obtained from the Pharmacy Foundation, the Egmont Foundation, the March of Dimes Birth Defects Foundation, the Augustinus Foundation, and the Health Foundation. The analyses presented in this article were funded by the Western Norwegian Regional Health Authority and by the Intramural Research Program at the National Institute of Environmental Health Sciences, NIH. In addition, the Norwegian Institute of Public Health, the University of Copenhagen, and Aarhus University contributed to the funding by paying for data files and linkage to registries, and providing administrative support. Funded by the National Institutes of Health (NIH). NR 35 TC 1 Z9 1 U1 7 U2 7 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 EI 1098-4275 J9 PEDIATRICS JI Pediatrics PD OCT PY 2016 VL 138 IS 4 AR e20160874 DI 10.1542/peds.2016-0874 PG 9 WC Pediatrics SC Pediatrics GA DX3ZT UT WOS:000384317700031 ER PT J AU Kotchenruther, RA AF Kotchenruther, Robert A. TI Source apportionment of PM2.5 at multiple Northwest US sites: Assessing regional winter wood smoke impacts from residential wood combustion SO ATMOSPHERIC ENVIRONMENT LA English DT Article DE Positive matrix factorization; Residential wood combustion; Wood smoke; Source apportionment; PM2.5 ID PARTICULATE MATTER; ESTIMATING UNCERTAINTY; SOURCE IDENTIFICATION; AMBIENT PM2.5; UNITED-STATES; AREA; CHALLENGES; PARTICLES; POLLUTION; MODELS AB Wood smoke from residential wood combustion is a significant source of elevated PM2.5 in many communities across the Northwest U.S. Accurate representation of residential wood combustion in source-oriented regional scale air quality models is challenging because of multiple uncertainties. As an alternative to source-oriented source apportionment, this work provides, through receptor-oriented source apportionment, an assessment of winter residential wood combustion impacts at multiple Northwest U.S. locations. Source apportionment was performed on chemically speciated PM2.5 from 19 monitoring sites using the Positive Matrix Factorization (PMF) receptor model. Each site was modeled independently, but a common data preparation and modeling protocol was used so that results were as comparable as possible across sites. Model solutions had from 4 to 8 PMF factors, depending on the site. PMF factors at each site were associated with a source classification (e.g., primary wood smoke), a dominant chemical composition (e.g., ammonium nitrate), or were some mixture. 15 different sources or chemical compositions were identified as contributing to PM2.5 across the 19 sites. The 6 most common were; aged wood smoke and secondary organic carbon, motor vehicles, primary wood smoke, ammonium nitrate, ammonium sulfate, and fugitive dust. Wood smoke was identified at every site, with both aged and primary wood smoke identified at most sites. Wood smoke contributions to PM2.5 were averaged for the two winter months of December and January, the months when wood smoke in the Northwest U.S. is mainly from residential wood combustion. The total contribution of residential wood combustion, that from primary plus aged smoke, ranged from 11.4% to 92.7% of average December and January PM2.5 depending on the site, with the highest percent contributions occurring in smaller towns that have fewer expected sources of winter PM2.5. Receptor modeling at multiple sites, such as that conducted in this work, provided some significant advantages over modeling a single or small number of sites. Analysis at multiple sites allowed common factor chemical compositions to be identified, making it easier to evaluate when a PMF factor at a particular site represents a mix of sources versus a single source. The identification of similar PMF factors across multiple sites also allowed average chemical profiles to be established for the 6 the most commonly identified PM2.5 sources or compositions in this study. These average profiles have the potential to be used as source profile inputs in future Chemical Mass Balance receptor modeling, when a limited number of samples may restrict the ability to conduct PMF receptor modeling, or when the availability of local source profiles is limited. Receptor modeling results spanning a range of community sizes and source compositions, as in this study, could be used to evaluate and improve the representation of wood smoke and other specific sources in source-oriented regional scale air quality models by providing an independent source impact assessment. Published by Elsevier Ltd. C1 [Kotchenruther, Robert A.] US Environm Protect Agcy Reg 10, Off Environm Review & Assessment, 1200 Sixth Ave,Mailstop OEA 140, Seattle, WA 98101 USA. RP Kotchenruther, RA (reprint author), US Environm Protect Agcy Reg 10, Off Environm Review & Assessment, 1200 Sixth Ave,Mailstop OEA 140, Seattle, WA 98101 USA. EM Kotchenruther.Robert@epa.gov NR 28 TC 0 Z9 0 U1 14 U2 14 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 EI 1873-2844 J9 ATMOS ENVIRON JI Atmos. Environ. PD OCT PY 2016 VL 142 BP 210 EP 219 DI 10.1016/j.atmosenv.2016.07.048 PG 10 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA DV9WO UT WOS:000383293100020 ER PT J AU Perry, SG Heist, DK Brouwer, LH Monbureau, EM Brixey, LA AF Perry, S. G. Heist, D. K. Brouwer, L. H. Monbureau, E. M. Brixey, L. A. TI Characterization of pollutant dispersion near elongated buildings based on wind tunnel simulations SO ATMOSPHERIC ENVIRONMENT LA English DT Article DE Wind tunnel; Dispersion; Building wake; Modeling; Downwash; AERMOD ID CONFIGURATIONS; VALIDATION; MODEL; FLOW; WAKE AB This paper presents a wind tunnel study of the effects of elongated rectangular buildings on the dispersion of pollutants from nearby stacks. The study examines the influence of source location, building aspect ratio, and wind direction on pollutant dispersion with the goal of developing improved algorithms within dispersion models. The paper also examines the current AERMOD/PRIME modeling capabilities compared to wind tunnel observations. Differences in the amount of plume material entrained in the wake region downwind of a building for various source locations and source heights are illustrated with vertical and lateral concentration profiles. These profiles were parameterized using the Gaussian equation and show the influence of building/source configurations on those parameters. When the building is oriented at 45 to the approach flow, for example, the effective plume height descends more rapidly than it does for a perpendicular building, enhancing the resulting surface concentrations in the wake region. Buildings at angles to the wind cause a cross-wind shift in the location of the plume resulting from a lateral mean flow established in the building wake. These and other effects that are not well represented in many dispersion models are important considerations when developing improved algorithms to estimate the location and magnitude of concentrations downwind of elongated buildings. Published by Elsevier Ltd. C1 [Perry, S. G.; Heist, D. K.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Brouwer, L. H.; Brixey, L. A.] Jacobs Technol Inc, Res Triangle Pk, NC USA. [Monbureau, E. M.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. RP Perry, SG (reprint author), MD 80,109 Alexander Dr, Res Triangle Pk, NC 27711 USA. EM perry.steven@epa.gov NR 19 TC 0 Z9 0 U1 8 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 EI 1873-2844 J9 ATMOS ENVIRON JI Atmos. Environ. PD OCT PY 2016 VL 142 BP 286 EP 295 DI 10.1016/j.atmosenv.2016.07.052 PG 10 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA DV9WO UT WOS:000383293100028 ER PT J AU Abualfaraj, N Olson, MS Gurian, PL De Roos, A Gross-Davis, CA AF Abualfaraj, Noura Olson, Mira S. Gurian, Patrick L. De Roos, Anneclaire Gross-Davis, Carol Ann TI Statistical analysis of compliance violations for natural gas wells in Pennsylvania SO ENERGY POLICY LA English DT Article DE Marcellus shale; Violations; Compliance; Fracking ID MARCELLUS SHALE; NORTHEASTERN PENNSYLVANIA; WATER WELLS; WASTE-WATER; EXTRACTION; RISKS; OIL; USA AB Regulatory inspection and violation reports provide insight into the impact of natural gas extraction on the surrounding environment, human health, and public safety. Inspection reports for natural gas wells in Pennsylvania were collected from the Pennsylvania DEP Compliance Report from 2000 to 2014. Analysis of 215,444 inspection records for 70,043 conventional and unconventional wells was conducted in order to compare the odds of violations occurring under different circumstances. Logistic regression models were used to estimate the probability of violations occurring for both conventional and unconventional wells. When inspected, conventional wells had 40% higher odds of having a violation. However, unconventional wells had higher odds for environmental violations related to waste discharge as well as cementing and casing failures. Large operators had 40% lower odds of having any violation than smaller operators. While larger operators had fewer violations, a few of the largest companies had rates of violation much higher than the average for all operators, with some reaching violation rates as high as 1 in 4 active wells. A well also has a higher chance of being in violation if it is in the first year (85%) or second year (109%) since its spud date. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Abualfaraj, Noura; Olson, Mira S.; Gurian, Patrick L.] Drexel Univ, Dept Civil Architectural & Environm Engn, Coll Engn, 3141 Chestnut St, Philadelphia, PA 19104 USA. [De Roos, Anneclaire; Gross-Davis, Carol Ann] Drexel Univ, Dornsife Sch Publ Hlth, Philadelphia, PA 19104 USA. [Gross-Davis, Carol Ann] US EPA, Reg 3, Washington, DC 20460 USA. RP Abualfaraj, N (reprint author), Drexel Univ, Dept Civil Architectural & Environm Engn, Coll Engn, 3141 Chestnut St, Philadelphia, PA 19104 USA. EM Na489@drexel.edu FU Drexel University's Drexel A. J. Institute for Energy and the Environment FX This research was funded by Drexel University's Drexel A. J. Institute for Energy and the Environment. James Gurian assisted with the formatting of the database. The authors thank the anonymous reviewers whose helpful comments greatly improved the manuscript. NR 34 TC 0 Z9 0 U1 19 U2 19 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0301-4215 EI 1873-6777 J9 ENERG POLICY JI Energy Policy PD OCT PY 2016 VL 97 BP 421 EP 428 DI 10.1016/j.enpol.2016.07.051 PG 8 WC Energy & Fuels; Environmental Sciences; Environmental Studies SC Energy & Fuels; Environmental Sciences & Ecology GA DV9WM UT WOS:000383292900040 ER PT J AU McGoldrick, DJ Murphy, EW AF McGoldrick, Daryl J. Murphy, Elizabeth W. TI Concentration and distribution of contaminants in lake trout and walleye from the Laurentian Great Lakes (2008-2012) SO ENVIRONMENTAL POLLUTION LA English DT Article DE Environmental contaminants; Great lakes; Fish; Biomonitoring ID POLYBROMINATED DIPHENYL ETHERS; BROMINATED FLAME RETARDANTS; POLYCHLORINATED BIPHENYL CONGENERS; FOOD-WEB; SALVELINUS-NAMAYCUSH; TEMPORAL TRENDS; POLYFLUOROALKYL SUBSTANCES; NONYLPHENOL ETHOXYLATES; TROPHIC MAGNIFICATION; SPATIAL-DISTRIBUTION AB Biomonitoring programs for persistent, bioaccumulative, and/or toxic chemicals of concern in fish tissues have been operated by the governments of Canada and the United States in the Great Lakes since the 1970's. The objectives of these programs are to assess concentrations of harmful chemicals in whole body top predator fish as an indicator of ecosystem health and to infer potential harm to fish and fish consuming wildlife in the Great Lakes Basin. Chemicals of interest are selected based upon national and binational commitments, risk assessment, and regulation, and include a wide range of compounds. This review summarizes all available data generated by Environment Canada and the United States Environmental Protection Agency for chemicals measured in whole body homogenates of Lake Trout (Salvelinus namaycush) and Walleye (Sander vitreus) for the time period spanning 2008 to 2012 from each of the five Great Lakes. The summary shows that concentrations of legacy compounds, such as, POPs listed in the Stockholm Convention and mercury continue to dominate the chemical burden of Great Lakes fish. This assessment, and others like it, can guide the creation of environmental quality targets where they are lacking, optimize chemical lists for monitoring, and prioritize chemicals of concern under agreements such as the Great Lakes Water Quality Agreement and the Stockholm Convention. Crown Copyright (C) 2015 Published by Elsevier Ltd. C1 [McGoldrick, Daryl J.] Environm & Climate Change Canada, Water Sci & Technol Directorate, 867 Lakeshore Rd, Burlington, ON, Canada. [Murphy, Elizabeth W.] US EPA, Great Lakes Natl Program Off, 77 W Jackson Blvd, Chicago, IL USA. RP McGoldrick, DJ (reprint author), Environm & Climate Change Canada, Water Sci & Technol Directorate, 867 Lakeshore Rd, Burlington, ON, Canada. EM Daryl.McGoldrick@Canada.ca OI McGoldrick, Daryl/0000-0001-8443-3564 NR 83 TC 1 Z9 1 U1 22 U2 22 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0269-7491 EI 1873-6424 J9 ENVIRON POLLUT JI Environ. Pollut. PD OCT PY 2016 VL 217 SI SI BP 85 EP 96 DI 10.1016/j.envpol.2015.12.019 PG 12 WC Environmental Sciences SC Environmental Sciences & Ecology GA DW7IT UT WOS:000383825100012 PM 26740246 ER PT J AU Melnyk, LJ Wang, ZH Li, ZL Xue, JP AF Melnyk, Lisa Jo Wang, Zhaohui Li, Zhilin Xue, Jianping TI Prioritization of pesticides based on daily dietary exposure potential as determined from the SHEDS model SO FOOD AND CHEMICAL TOXICOLOGY LA English DT Article DE Risk ranking; Pesticides; Dietary exposure; ADI ID MULTIMEDIA MODEL; CHILDREN; NHANES; RESIDUES; RANKING; RISK AB A major pathway for exposure to many pesticides is through diet. The objectives were to rank pesticides by comparing their calculated daily dietary exposure as determined by EPA's Stochastic Human Exposure and Dose Simulation (SHEDS) to single pesticides for different age groups to acceptable daily intakes (ADI), characterize pesticide trends in exposures over different time periods, and determine commodities contributing to pesticide exposures. SHEDS was applied, using Pesticide Data Program (PDP) (1991-2011) and pesticide usage data on crops from USDA combined with NHANES dietary consumption data, to generate exposure estimates by age group. ADI data collected from EPA, WHO, and other sources were used to rank pesticides based on relativeness of the dietary exposure potential to ADI by age groups. Sensitivity analysis provided trends in pesticide exposures. Within SHEDS, commodities contributing the majority of pesticides with greatest exposure potential were determined. The results indicated that the highest ranking pesticides were methamidophos and diazinon which exceeded 100% of the ADI. Sensitivity analysis indicated that exposure to methamidophos, diazinon, malathion, ethion and formetanate hydrochloride had a marked decrease from 1991-1999 to 2000-2011. Contributions analysis indicated that apples, mushroom, carrots, and lettuce contributed to diazinon exposure. Beans and pepper contributed to methamidophos exposure. Published by Elsevier Ltd. C1 [Melnyk, Lisa Jo] US EPA, Off Res & Dev, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. [Wang, Zhaohui; Xue, Jianping] US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Wang, Zhaohui; Li, Zhilin] North Carolina State Univ, Dept Math, Box 8205, Raleigh, NC 27695 USA. RP Melnyk, LJ (reprint author), US EPA, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA.; Xue, JP (reprint author), US EPA, 109 TW Alexander Dr,MD E205-02, Res Triangle Pk, NC 27711 USA. EM Melnyk.lisa@epa.gov; xue.jianping@epa.gov NR 18 TC 0 Z9 0 U1 7 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0278-6915 EI 1873-6351 J9 FOOD CHEM TOXICOL JI Food Chem. Toxicol. PD OCT PY 2016 VL 96 BP 167 EP 173 DI 10.1016/j.fct.2016.07.025 PG 7 WC Food Science & Technology; Toxicology SC Food Science & Technology; Toxicology GA DW7IV UT WOS:000383825300018 PM 27497764 ER PT J AU Liu, XY Guo, ZS Krebs, KA Roache, NF Stinson, RA Nardin, JA Pope, RH Mocka, CA Logan, RD AF Liu, Xiaoyu Guo, Zhishi Krebs, Kenneth A. Roache, Nancy F. Stinson, Rayford A. Nardin, Joshua A. Pope, Robert H. Mocka, Corey A. Logan, Russell D. TI Laboratory evaluation of polychlorinated biphenyls encapsulation methods SO INDOOR AND BUILT ENVIRONMENT LA English DT Article DE Polychlorinated biphenyls; Encapsulation; Abatement technique; Sink chamber tests; Wipe sampling; Barrier modelling; Solid; air partition coefficient; Solid-phase diffusion coefficient; Material; material partition coefficient ID BUILDING-MATERIALS; PCB; EMISSIONS; CONTAMINATION; PRODUCTS; FUGACITY; SURFACES AB Effectiveness and limitations of encapsulation methods for reducing polychlorinated biphenyls concentration in indoor air and abating contaminated surface have been evaluated. Ten coating materials such as epoxy and polyurethane coatings, latex paint and petroleum-based paint were tested in small environmental chambers to rank encapsulants by their resistance to polychlorinated biphenyl sorption (sink chamber tests) and to determine key parameters for consideration by a barrier model. Wipe samples were collected from polychlorinated biphenyl contaminated surfaces encapsulated with coating materials to rank encapsulants by their resistance to polychlorinated biphenyl migration from the source. A barrier model was used to calculate the polychlorinated biphenyl concentration gradient in the source and encapsulant layers on exposed surfaces of encapsulants and in room air at different times. The performance of encapsulants was ranked by those concentrations and polychlorinated biphenyl percentage reductions. Overall, the three epoxy coatings performed better than other coatings. Both experimental results and mathematical modelling showed that selecting proper encapsulants can effectively reduce polychlorinated biphenyl concentrations on exposed surfaces. The encapsulation method could be an effective short-term abatement technique for containing emission of low levels of polychlorinated biphenyls from contaminated surfaces. Barrier models are useful tools for ranking the relative performances of encapsulants once their material/material K-1,K-2, material/air partition coefficients (K-ma) and solid-phase diffusion coefficients (D-m) are obtained. C1 [Liu, Xiaoyu; Krebs, Kenneth A.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Air Pollut Prevent & Control Div, Res Triangle Pk, NC 27711 USA. [Guo, Zhishi] US EPA, Res Triangle Pk, NC 27711 USA. [Roache, Nancy F.; Stinson, Rayford A.; Nardin, Joshua A.; Pope, Robert H.; Mocka, Corey A.; Logan, Russell D.] Arcadis US Inc, Durham, NC USA. RP Liu, XY (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Air Pollut Prevent & Control Div, Res Triangle Pk, NC 27711 USA. EM liu.xiaoyu@epa.gov NR 33 TC 0 Z9 0 U1 6 U2 6 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1420-326X EI 1423-0070 J9 INDOOR BUILT ENVIRON JI Indoor Built Environ. PD OCT PY 2016 VL 25 IS 6 BP 895 EP 915 DI 10.1177/1420326X16645150 PG 21 WC Construction & Building Technology; Engineering, Environmental; Public, Environmental & Occupational Health SC Construction & Building Technology; Engineering; Public, Environmental & Occupational Health GA DW9CI UT WOS:000383951900004 ER PT J AU Duan, Y Zhao, Y Wu, YZ He, JX Xu, L Zhang, XL Ma, LH Qian, RR AF Duan, Yi Zhao, Yang Wu, Yingzhong He, Jinxian Xu, Li Zhang, Xiaoli Ma, Lanhua Qian, Raorong TI delta D values of n-alkanes in sediments from Gahai Lake, Gannan, China: implications for sources of organic matter SO JOURNAL OF PALEOLIMNOLOGY LA English DT Article DE Gannan Gahai freshwater Lake; Qinghai-Tibet plateau; Sedimentary n-alkane; Hydrogen isotopes; Organic matter source ID HYDROGEN ISOTOPIC COMPOSITION; TIBETAN PLATEAU; LEAF WAX; SURROUNDING AREA; MARINE-SEDIMENTS; LACUSTRINE SEDIMENTS; TERRESTRIAL PLANTS; LIPID BIOMARKERS; RATIOS; GEOCHEMISTRY AB Gahai Lake in the Gannan region, located in the northeast of the Tibetan Plateau, is the largest pristine freshwater lake on the plateau. Surface sediments in the Gahai Lake were systematically sampled, and n-alkane distribution and hydrogen isotope were analyzed by a gas chromatograph-mass spectrometer and a gas chromatograph-interface-isotope ratio mass spectrometer. The delta D values of n-alkanes in the sediments ranged from -247 to -161 % and the mean values varied between -222 and -182 %. The studied sediments were divided into types I and II based on the average delta D values of n-alkanes. The average delta D values of n-alkanes in type I sediments were significantly higher than those in type II sediments and there were good correlations among the delta D values of the n-alkanes from the two sediment types. The delta D values of type I sediments indicated that the C-21-C-33 odd-numbered n-alkanes were derived mainly from aquatic plants in the Gahai Lake, while the delta D values of type II sediments showed that C-27-C-33 odd-number n-alkanes were derived from terrestrial herbaceous plants. This assessment of n-alkane sources was also confirmed by their distributions. It was inferred that the medium-chain length n-alkanes of relatively high abundance, low delta D values, and low carbon preference index values were derived principally from bacteria. The distribution patterns of the sedimentary n-alkane delta D values for the plateau humid-climate freshwater lake and dry-climate saline lake systems were compared. The results further confirmed that sedimentary n-alkanes record the hydrogen isotopic composition of source water used by organisms. Therefore, delta D values of sedimentary n-alkanes can be used as geochemical indicators for sources of sedimentary organic matter and in paleoclimate studies. Our results also showed that the delta D values of n-alkanes from sediments within the lake can differ significantly for a given time period owing to their different biological sources. This should be taken into account when reconstructing paleoclimatic and hydrologic conditions using sedimentary n-alkane delta D values. C1 [Duan, Yi; Zhao, Yang; Wu, Yingzhong] Chinese Acad Sci, Inst Geol & Geophys, Key Lab Petr Resources, Gansu Prov Key Lab Petr Resources Res, Lanzhou 730000, Peoples R China. [Duan, Yi] Changan Univ, Sch Earth Sci & Resources, Xian 710054, Peoples R China. [Zhao, Yang; Wu, Yingzhong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China. [He, Jinxian; Zhang, Xiaoli] China Univ Min & Technol, Xuzhou 221116, Peoples R China. [Xu, Li] Res Inst Petr Explorat & Dev, Lanzhou 730020, Peoples R China. [Ma, Lanhua] China Earthquake Adm, Earthquake Res Inst Lanzhou, Lanzhou 730000, Peoples R China. [Qian, Raorong] US EPA, Analyt Chem Branch, BEAD, Off Pesticide Programs, 701 Mapes Rd, Ft George G Meade, MD 20755 USA. RP Duan, Y (reprint author), Chinese Acad Sci, Inst Geol & Geophys, Key Lab Petr Resources, Gansu Prov Key Lab Petr Resources Res, Lanzhou 730000, Peoples R China. EM duany@lzb.ac.cn FU National Natural Science Foundation of China [41272125, 41472121] FX This study was supported by the National Natural Science Foundation of China (Grant Nos. 41272125 and 41472121). We thank Dr. Jia Xia for the assistance in the field. We thank Dr. Ines Mugler and five anonymous reviewers for valuable suggestions and critical comments. NR 50 TC 0 Z9 0 U1 18 U2 18 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0921-2728 EI 1573-0417 J9 J PALEOLIMNOL JI J. Paleolimn. PD OCT PY 2016 VL 56 IS 2-3 BP 95 EP 107 DI 10.1007/s10933-016-9895-1 PG 13 WC Environmental Sciences; Geosciences, Multidisciplinary; Limnology SC Environmental Sciences & Ecology; Geology; Marine & Freshwater Biology GA DW9OC UT WOS:000383989300001 ER PT J AU Xu, YR Wallace, MAG Fitzgerald, MC AF Xu, Yingrong Wallace, M. Ariel Geer Fitzgerald, Michael C. TI Thermodynamic Analysis of the Geldanamycin-Hsp90 Interaction in a Whole Cell Lysate Using a Mass Spectrometry-Based Proteomics Approach SO JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY LA English DT Article DE Protein folding; Thermodynamic stability; Binding affinity; Heat shock protein 90; Chemical denaturation; Isobaric mass tags; Protein-ligand binding; Covalent labeling ID HSP90 MOLECULAR CHAPERONE; PROTEIN 90 HSP90; SACCHAROMYCES-CEREVISIAE; CRYSTAL-STRUCTURE; TERMINAL DOMAIN; INHIBITION; COMPLEX; BINDING; DERIVATIVES; STABILITY AB Geldanamycin is a natural product with well-established and potent anti-cancer activities. Heat shock protein 90 (Hsp90) is the known target of geldanamycin, which directly binds to Hsp90's N-terminal ATP binding domain and inhibits Hsp90's ATPase activity. The affinity of geldanamycin for Hsp90 has been measured in multiple studies. However, there have been large discrepancies between the reported dissociation constants (i.e., K-d values), which have ranged from low nanomolar to micromolar. Here the stability of proteins from rates of oxidation (SPROX) technique was used in combination with an isobaric mass tagging strategy to measure the binding affinity of geldanamycin to unpurified Hsp90 in an MCF-7 cell lysate. The K-d values determined here were dependent on how long geldanamycin was equilibrated with the lysate prior to SPROX analysis. The K-d values determined using equilibration times of 0.5 and 24 h were 1 and 0.03 mu M, respectively. These K-d values, which are similar to those previously reported in a geldanamycin-Hsp90 binding study that involved the use of a fluorescently labeled geldanamycin analogue, establish that the slow-tight binding behavior previously observed for the fluorescently labeled geldanamycin analogue is not an artifact of the fluorescent label, but rather an inherent property of the geldanamycin-Hsp90 binding interaction. The slow-tight binding property of this complex may be related to time-dependent conformational changes in Hsp90 and/or to time-dependent chemical changes in geldanamycin, both of which have been previously proposed to explain the slow-tight binding behavior of the geldanamycin-Hsp90 complex. C1 [Xu, Yingrong] Pfizer Inc, Groton, CT 06340 USA. [Wallace, M. Ariel Geer] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27709 USA. [Xu, Yingrong; Wallace, M. Ariel Geer; Fitzgerald, Michael C.] Duke Univ, Dept Chem, Durham, NC 27708 USA. RP Fitzgerald, MC (reprint author), Duke Univ, Dept Chem, Durham, NC 27708 USA. EM michael.c.fitzgerald@duke.edu FU National Science Foundation [CHE-1308093] FX The authors thank the Proteomics Facility at the Fred Hutchinson Cancer Research Center for collecting the LC-MS/MS data in Hybrid-Short and SRPOX-Long experiments. They also thank the Duke Proteomics Facility for collecting the LC-MS/MS data in the SPROX-Short experiment. This work was supported by a grant from the National Science Foundation (CHE-1308093) to M.C.F. NR 35 TC 0 Z9 0 U1 12 U2 12 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1044-0305 EI 1879-1123 J9 J AM SOC MASS SPECTR JI J. Am. Soc. Mass Spectrom. PD OCT PY 2016 VL 27 IS 10 BP 1670 EP 1676 DI 10.1007/s13361-016-1457-2 PG 7 WC Biochemical Research Methods; Chemistry, Analytical; Chemistry, Physical; Spectroscopy SC Biochemistry & Molecular Biology; Chemistry; Spectroscopy GA DV6FM UT WOS:000383028000011 PM 27530778 ER PT J AU Benson, R Berry, D Lockey, J Brattin, W Hilbert, T LeMasters, G AF Benson, Robert Berry, David Lockey, James Brattin, William Hilbert, Timothy LeMasters, Grace TI Response to comment on "Exposure-response modeling of non-cancer effects in humans exposed to Libby Amphibole Asbestos; update" by Benson et al. (2015) submitted by Goodman et al. (2016) SO REGULATORY TOXICOLOGY AND PHARMACOLOGY LA English DT Letter ID PLEURAL PLAQUES C1 [Benson, Robert; Berry, David] US EPA, 1595 Wynkoop St, Denver, CO 80202 USA. [Lockey, James; Hilbert, Timothy; LeMasters, Grace] Univ Cincinnati, Dept Environm Hlth, 160 Panzeca Way, Cincinnati, OH 45267 USA. [Lockey, James] Univ Cincinnati, Dept Internal Med, Div Pulm, 160 Panzeca Way, Cincinnati, OH 45267 USA. [Brattin, William] SRC Inc, Suite 1380,999 18th St, Denver, CO 80202 USA. RP Benson, R (reprint author), US EPA, 1595 Wynkoop St, Denver, CO 80202 USA. EM benson.bob@epa.gov; berry.david@epa.gov; lockeyje@ucmail.uc.edu; brattin@srcinc.com; hilberttj@ucmail.uc.edu; lemastgj@ucmail.uc.edu NR 4 TC 1 Z9 1 U1 2 U2 3 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0273-2300 EI 1096-0295 J9 REGUL TOXICOL PHARM JI Regul. Toxicol. Pharmacol. PD OCT PY 2016 VL 80 BP 270 EP 271 DI 10.1016/j.yrtph.2016.05.015 PG 2 WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology SC Legal Medicine; Pharmacology & Pharmacy; Toxicology GA DW0EY UT WOS:000383314900027 PM 27191601 ER PT J AU Haggard, DE Noyes, PD Waters, KM Tanguay, RL AF Haggard, Derik E. Noyes, Pamela D. Waters, Katrina M. Tanguay, Robert L. TI Phenotypically anchored transcriptome profiling of developmental exposure to the antimicrobial agent, triclosan, reveals hepatotoxicity in embryonic zebrafish SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article DE Triclosan; Zebrafish; Transcriptomics; Phenotypic anchoring; Hepatotoxicity; ToxCast ID CHRONIC LIVER-DISEASE; WATER TREATMENT-PLANT; EARLY-LIFE STAGES; LARGE GENE LISTS; IN-VITRO; URINARY CONCENTRATIONS; FUNCTIONAL-ANALYSIS; NEONATAL THYROXINE; FLAME RETARDANTS; US POPULATION AB Triclosan (TCS) is an antimicrobial agent commonly found in a variety of personal care products and cosmetics. TCS readily enters the environment through wastewater and is detected in human plasma, urine, and breast milk due to its widespread use. Studies have implicated TCS as a disruptor of thyroid and estrogen signaling; therefore, research examining the developmental effects of TCS is warranted. In this study, we used embryonic zebrafish to investigate the developmental toxicity and potential mechanism of action of TCS. Embryos were exposed to graded concentrations of TCS from 6 to 120 hours post-fertilization (hpf) and the concentration where 80% of the animals had mortality or morbidity at 120 hpf (EC80) was calculated. Transcriptomic profiling was conducted on embryos exposed to the EC80 (7.37 mu M). We identified a total of 922 significant differentially expressed transcripts (FDR adjusted P-value <= 0.05; fold change >= 2). Pathway and gene ontology enrichment analyses identified biological networks and transcriptional hubs involving normal liver functioning, suggesting TCS may be hepatotoxic in zebrafish. Tissue-specific gene enrichment analysis further supported the role of the liver as a target organ for TCS toxicity. We also examined the in vitro bioactivity profile of TCS reported by the ToxCast screening program. TCS had a diverse bioactivity profile and was a hit in 217 of the 385 assay endpoints we identified. We observed similarities in gene expression and hepatic steatosis assays; however, hit data for TCS were more concordant with the hypothesized CAR/PXR activity of TCS from rodent and human in vitro studies. (C) 2016 Elsevier Inc. All rights reserved. C1 [Haggard, Derik E.; Noyes, Pamela D.; Tanguay, Robert L.] Oregon State Univ, Dept Environm & Mol Toxicol, Corvallis, OR 97331 USA. [Noyes, Pamela D.] US EPA, Off Sci Coordinat & Policy, Off Chem Safety & Pollut Prevent, Washington, DC 20460 USA. [Waters, Katrina M.] Pacific Northwest Natl Lab, Div Biol Sci, Richland, WA USA. RP Tanguay, RL (reprint author), Oregon State Univ, Dept Environm & Mol Toxicol, Sinnhuber Aquat Res Lab, 28645 East Highway 34, Corvallis, OR 97333 USA. EM Robert.Tanguay@oregonstate.edu FU NIH [P30 ES000210, T32 ES007060, P42 ES016465]; EPA [R835168]; Battelle for the U.S. Department of Energy [DE-AC05-76RL01830] FX We would like to acknowledge Carrie Barton and Greg Gonnerman, Sinnhuber Aquatic Research Laboratory, for providing help and support with fish husbandry, spawning, and embryo screening. We would also like to thank Dr. Lisa Truong and Dr. Michael Simonich for assistance with manuscript preparation and editing. This research was supported by NIH P30 ES000210, T32 ES007060, P42 ES016465 and EPA #R835168. Pacific Northwest National Laboratory is a multi-program laboratory operated by Battelle for the U.S. Department of Energy under Contract DE-AC05-76RL01830. NR 91 TC 1 Z9 1 U1 16 U2 16 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0041-008X EI 1096-0333 J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD OCT 1 PY 2016 VL 308 BP 32 EP 45 DI 10.1016/j.taap.2016.08.013 PG 14 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA DW8RR UT WOS:000383923700004 PM 27538710 ER PT J AU Soldatow, V Peffer, RC Trask, OJ Cowie, DE Andersen, ME LeCluyse, E Deisenroth, C AF Soldatow, Valerie Peffer, Richard C. Trask, O. Joseph Cowie, David E. Andersen, Melvin E. LeCluyse, Edward Deisenroth, Chad TI Development of an in vitro high content imaging assay for quantitative assessment of CAR-dependent mouse, rat, and human primary hepatocyte proliferation SO TOXICOLOGY IN VITRO LA English DT Article DE Primary hepatocytes; Cell proliferation; High content imaging; Car ID CONSTITUTIVE ANDROSTANE RECEPTOR; EPIDERMAL-GROWTH-FACTOR; LIVER-TUMOR PROMOTERS; DNA-SYNTHESIS; PRIMARY CULTURES; PEROXISOME PROLIFERATORS; CELL-PROLIFERATION; INDUCTION; OXAZEPAM; MICE AB Rodent liver tumors promoted by constitutive androstane receptor (CAR) activation are known to be mediated by key events that include CAR-dependent gene expression and hepatocellular proliferation. Here, an in vitro high content imaging based assay was developed for quantitative assessment of nascent DNA synthesis in primary hepatocyte cultures from mouse, rat, and human species. Detection of DNA synthesis was performed using direct DNA labeling with the nucleoside analog 5-ethynyl-2'-deoxyuridine (EdU). The assay was multiplexed to enable direct quantitation of DNA synthesis, cytotoxicity, and cell count endpoints. An optimized defined medium cocktail was developed to sensitize hepatocytes to cell cycle progression. The baseline EdU response to defined medium was greatest for mouse, followed by rat, and then human. Hepatocytes from all three species demonstrated CAR, activation in response to the CAR agonists TCPOBOP, CITCO, and phenobarbital based on increased gene expression for Cyp2b isoforms. When evaluated for a proliferation phenotype, TCPOBOP and CITCO exhibited significant dose-dependent increases in frequency of EdU labeling in mouse and rat hepatocytes that was not observed in hepatocytes from three human donors. The observed species differences are consistent with CAR activators inducing a proliferative response in rodents, a key event in the liver tumor mode of action that is not observed in humans. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Soldatow, Valerie; Trask, O. Joseph; Andersen, Melvin E.; LeCluyse, Edward; Deisenroth, Chad] Hamner Inst Hlth Sci, Inst Chem Safety Sci, 6 Davis Dr,POB 12137, Res Triangle Pk, NC 27709 USA. [Peffer, Richard C.; Cowie, David E.] Syngenta Crop Protect LLC, POB 18300,410 Swing Rd, Greensboro, NC 27419 USA. [Andersen, Melvin E.; Deisenroth, Chad] ScitoVation LLC, 6 Davis Dr,POB 110566, Res Triangle Pk, NC 27709 USA. [Deisenroth, Chad] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27709 USA. RP Deisenroth, C (reprint author), Hamner Inst Hlth Sci, Inst Chem Safety Sci, 6 Davis Dr,POB 12137, Res Triangle Pk, NC 27709 USA. EM deisenroth.chad@epa.gov FU Syngenta Crop Protection; American Chemistry Council Long Range Research Initiative; LLC FX This work was supported by Syngenta Crop Protection, LLC and the American Chemistry Council Long Range Research Initiative. NR 36 TC 0 Z9 0 U1 4 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0887-2333 J9 TOXICOL IN VITRO JI Toxicol. Vitro PD OCT PY 2016 VL 36 BP 224 EP 237 DI 10.1016/j.tiv.2016.08.006 PG 14 WC Toxicology SC Toxicology GA DW7JC UT WOS:000383826000026 PM 27530964 ER PT J AU Pond, GJ Fritz, KM Johnson, BR AF Pond, Gregory J. Fritz, Ken M. Johnson, Brent R. TI Macroinvertebrate and organic matter export from headwater tributaries of a Central Appalachian stream SO HYDROBIOLOGIA LA English DT Article DE Drift; Headwater streams; Central Appalachian Mountains; Aquatic insects; Dispersal ID LENGTH-MASS RELATIONSHIPS; INVERTEBRATE DRIFT; BENTHIC INVERTEBRATES; DISPERSAL; DOWNSTREAM; RESTORATION; COMMUNITIES; DIVERSITY; TAXA; FLOW AB Headwater streams export organisms and other materials to receiving streams, and macroinvertebrate drift can shape colonization dynamics in downstream reaches while providing food for downstream consumers. Spring-time drift and organic matter export was measured once monthly (February-May) over a 24-h period near the outlets of 12 eastern Kentucky (USA) streams to document and explore factors governing downstream transport. We compared drift measures as loads (day(-1)) and concentrations (volume(-1)) including drift density, biomass, richness, composition, and particulate organic matter across catchment area, month, reach scale factors, and network proximity. Aquatic invertebrate drift densities were roughly 10 times greater than terrestrial invertebrate densities; aquatic richness ranged from 18 to 45 taxa with Ephemeroptera, Plecoptera, Trichoptera, and Diptera genera dominating drift sample richness and abundance. Ordination revealed that assemblages clustered by month and catchment area; organic matter exports (loads or concentrations) also varied by month and catchment area factors. While drift measures were correlated with catchment area and sample date, local factors (e.g., substrate composition, riffle length, channel slope, and network proximity) were generally non-influential. The findings can be used to inform preservation and restoration strategies where headwater streams serve as sources of colonizers and provide food subsidies to receiving streams. C1 [Pond, Gregory J.] US EPA, Off Monitoring & Assessment, Reg 3,1060 Chapline St, Wheeling, WV 26003 USA. [Fritz, Ken M.; Johnson, Brent R.] US EPA, Off Res & Dev, Natl Exposure Res Div, Martin Luther King Jr Dr, Cincinnati, OH 45268 USA. RP Pond, GJ (reprint author), US EPA, Off Monitoring & Assessment, Reg 3,1060 Chapline St, Wheeling, WV 26003 USA. EM Pond.Greg@epa.gov NR 62 TC 0 Z9 0 U1 20 U2 20 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0018-8158 EI 1573-5117 J9 HYDROBIOLOGIA JI Hydrobiologia PD OCT PY 2016 VL 779 IS 1 BP 75 EP 91 DI 10.1007/s10750-016-2800-0 PG 17 WC Marine & Freshwater Biology SC Marine & Freshwater Biology GA DU2MQ UT WOS:000382045600006 ER PT J AU Akers, PD Brook, GA Railsback, LB Liang, FY Iannone, G Webster, JW Reeder, PP Cheng, H Edwards, RL AF Akers, Pete D. Brook, George A. Railsback, L. Bruce Liang, Fuyuan Iannone, Gyles Webster, James W. Reeder, Philip P. Cheng, Hai Edwards, R. Lawrence TI An extended and higher-resolution record of climate and land use from stalagmite MC01 from Macal Chasm, Belize, revealing connections between major dry events, overall climate variability, and Maya sociopolitical changes SO PALAEOGEOGRAPHY PALAEOCLIMATOLOGY PALAEOECOLOGY LA English DT Article DE Classic Maya collapse; Paleoclimate; Stalagmite; Speleothem; Belize; Resilience ID NINO-SOUTHERN-OSCILLATION; MODERN SPELEOTHEM CALCITE; ANCIENT MAYA; YUCATAN PENINSULA; PALEOENVIRONMENTAL RECONSTRUCTION; C-13/C-12 RATIOS; ORGANIC-MATTER; CLASSIC PERIOD; CENTRAL TEXAS; SOIL-EROSION AB The stalagmite MC01 was recovered from Macal Chasm cave on the Vaca Plateau of Belize in 1995, and an initial paleoclimate interpretation was published in 2007. Additional uranium-thorium ages have extended the paleoenvironmental record back from 3250 to 5250 cal yr BP, and the stable isotope (delta O-18 and delta C-13) record is dramatically improved by 660 new values. A series of major dry events (MDEs) evident in stable isotopes, ultraviolet-stimulated luminescence, and petrography began-3100 cal yr BP, and the initiation of these events coincides with an increase in El Nino dominance and southern shift in the Intertropical Convergence Zone. Three MDEs, centered at 1750 cal yr BP (200 CE), 1100 cal yr BP (850 CE), and 850 cal yr BP (1100 CE) and found in other regional climate records, coincide with Maya sociopolitical changes. Residuals from regression of delta C-13 versus 8180 are interpreted as a proxy for maize cultivation and land clearing, with residual values gradually increasing at the start of Preclassic Period settlement (3950 cal yr BP/2000 BCE), peaking after 2250 cal yr BP (300 BCE) during major Maya development in the Late Preclassic and Classic Periods, and dropping to pre-Preclassic values after regional land abandonment (similar to 850 cal yr BP/1100 CE). Regional Maya population growth and cultural expansion may have been aided by abnormally low precipitation variability, as stable isotope variability suggests the Late Preclassic through the Late Classic was the most stable precipitation regime of the past 4000 years. This additional research on MCO1 complements other regional paleoenvironmental records that suggest that MDEs coincided with disruptions in Maya society from the Preclassic through the Postclassic Periods. Although it is clear that not all significant sociopolitical changes can be attributed to the MDEs, these events likely played an antagonistic role in social stability. (C) 2016 Elsevier B.V. All rights reserved. C1 [Akers, Pete D.; Brook, George A.] Univ Georgia, Dept Geog, Athens, GA 30602 USA. [Railsback, L. Bruce] Univ Georgia, Dept Geol, Athens, GA 30602 USA. [Liang, Fuyuan] Western Illinois Univ, Dept Geog, Macomb, IL 61455 USA. [Iannone, Gyles] Trent Univ, Dept Anthropol, Peterborough, ON K9L 0G2, Canada. [Webster, James W.] US EPA, Atlanta, GA 30303 USA. [Reeder, Philip P.] Duquesne Univ, Bayer Sch Nat & Environm Sci, Pittsburgh, PA 15282 USA. [Cheng, Hai] Xi An Jiao Tong Univ, Coll Global Environm Change, Xian 710049, Shaanxi, Peoples R China. [Cheng, Hai; Edwards, R. Lawrence] Univ Minnesota, Dept Geol & Geophys, Minneapolis, MN 55455 USA. RP Akers, PD (reprint author), Dept Geog, 210 Field St, Athens, GA 30602 USA. EM pakers@uga.edu FU Alphawood Foundation FX This research was funded by the Alphawood Foundation. We thank Jason S. Polk, Bill Reynolds, and Madeline Reynolds for assistance in the field, and express our gratitude to the Belize Institute of Archaeology, and particularly Jaime Awe and John Morris, for their support of this transdisciplinary project. We also thank two reviewers for their very helpful suggestions and comments. NR 110 TC 0 Z9 0 U1 15 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0031-0182 EI 1872-616X J9 PALAEOGEOGR PALAEOCL JI Paleogeogr. Paleoclimatol. Paleoecol. PD OCT 1 PY 2016 VL 459 BP 268 EP 288 DI 10.1016/j.palaeo.2016.07.007 PG 21 WC Geography, Physical; Geosciences, Multidisciplinary; Paleontology SC Physical Geography; Geology; Paleontology GA DV0EU UT WOS:000382591600019 ER PT J AU Rankin, K Mabury, SA Jenkins, TM Washington, JW AF Rankin, Keegan Mabury, Scott A. Jenkins, Thomas M. Washington, John W. TI A North American and global survey of perfluoroalkyl substances in surface soils: Distribution patterns and mode of occurrence SO CHEMOSPHERE LA English DT Article DE PFOA; PFOS; PFASs; Background soils; Reconnaissance survey ID PERFLUORINATED CARBOXYLIC-ACIDS; POLYFLUORINATED ALKYL SUBSTANCES; FLUOROTELOMER-BASED POLYMERS; SLUDGE-APPLIED SOILS; POLYFLUOROALKYL SUBSTANCES; PERFLUOROOCTANE SULFONATE; MANUFACTURING FACILITY; UK SOILS; ALCOHOLS; WATER AB The distribution of 32 per/polyfluoroalkyl substances (PFASs) in surface soils was determined at 62 locations representing all continents (North America n = 33, Europe n = 10, Asia n = 6, Africa n = 5, Australia n = 4, South America n = 3 and Antarctica n = 1) using ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) systems. Quantifiable levels of perfluoroalkyl carboxylates (PFCAs: PFHxA-PFTeDA) were observed in all samples with total concentrations ranging from 29 to 14,300 pg/g (dry weight), while perfluoroalkane sulfonates (PFSAs: PFHxS, PFOS and PFDS) were detected in all samples but one, ranging from 20 mu g/L silver at most of the taps that were sampled, which further increased after flushing. However, silver plating onto copper pipe surfaces (in the cold water line but particularly in the hot water line) prevented reaching 20 mu g/L silver in cold and/or hot water of some taps. Aesthetically displeasing purple/grey stains in bathroom porcelain were attributed to chlorargyrite [AgCl(s)], an insoluble precipitate that formed when CSI-dosed Ag+ ions combined with Cl- ions that were present in the incoming water. Overall, CSI aims to control Legionella bacteria in drinking water, but plumbing material interactions, aesthetics and other implications also deserve consideration to holistically evaluate in-building drinking water disinfection. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Triantafyllidou, Simoni] US EPA, Oak Ridge Inst Sci & Educ, Off Res & Dev, Cincinnati, OH 45268 USA. [Lytle, Darren; Muhlen, Christy] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Water Supply & Water Resources Div, Cincinnati, OH 45268 USA. [Swertfeger, Jeff] Greater Cincinnati Water Works, Cincinnati, OH 45230 USA. RP Triantafyllidou, S (reprint author), US EPA, Oak Ridge Inst Sci & Educ, Off Res & Dev, Cincinnati, OH 45268 USA. EM triantafyllidou.simoni@epa.gov NR 39 TC 0 Z9 0 U1 50 U2 51 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0043-1354 J9 WATER RES JI Water Res. PD OCT 1 PY 2016 VL 102 BP 1 EP 10 DI 10.1016/j.watres.2016.06.010 PG 10 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA DU1EG UT WOS:000381950400001 PM 27318299 ER PT J AU Camejo, PY Owen, BR Martirano, J Ma, J Kapoor, V Domingo, JS McMahon, KD Noguera, DR AF Camejo, Pamela Y. Owen, Brian R. Martirano, Joseph Ma, Juan Kapoor, Vikram Domingo, Jorge Santo McMahon, Katherine D. Noguera, Daniel R. TI Candidatus Accumulibacter phosphatis clades enriched under cyclic anaerobic and microaerobic conditions simultaneously use different electron acceptors SO WATER RESEARCH LA English DT Article DE Low-DO nutrient removal; SNDPR; PAO; DPAO; Accumulibacter; ppk1 gene ID BIOLOGICAL PHOSPHORUS REMOVAL; SEQUENCING BATCH REACTOR; POLYPHOSPHATE ACCUMULATING ORGANISMS; MICROBIAL COMMUNITY STRUCTURE; WATER TREATMENT PLANTS; LOW-DISSOLVED-OXYGEN; ACTIVATED-SLUDGE; WASTE-WATER; SIMULTANEOUS NITRIFICATION; PSEUDOMONAS-AERUGINOSA AB Lab- and pilot-scale simultaneous nitrification, denitrification and phosphorus removal-sequencing batch reactors were operated under cyclic anaerobic and micro-aerobic conditions. The use of oxygen, nitrite, and nitrate as electron acceptors by Candidatus Accumulibacter phosphatis during the micro aerobic stage was investigated. A complete Glade-level characterization of Accumulibacter in both reactors was performed using newly designed qPCR primers targeting the polyphosphate kinase gene (ppkl). In the lab-scale reactor, limited-oxygen conditions led to an alternated dominance of Clade IID and IC over the other clades. Results from batch tests when Clade IC was dominant (i.e., >92% of Accumulibacter) showed that this Glade was capable of using oxygen, nitrite and nitrate as electron acceptors for P uptake. A more heterogeneous distribution of clades was found in the pilot-scale system (Clades IIA, IIB, IIC, IID, IA, and IC), and in this reactor, oxygen, nitrite and nitrate were also used as electron acceptors coupled to phosphorus uptake. However, nitrite was not an efficient electron acceptor in either reactor, and nitrate allowed only partial P removal. The results from the Clade IC dominated reactor indicated that either organisms in this clade can simultaneously use multiple electron acceptors under micro-aerobic conditions, or that the use of multiple electron acceptors by Clade IC is due to significant microdiversity within the Accumulibacter clades defined using the ppkl gene. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Camejo, Pamela Y.; Owen, Brian R.; Martirano, Joseph; McMahon, Katherine D.; Noguera, Daniel R.] Univ Wisconsin, Dept Civil & Environm Engn, Madison, WI 53706 USA. [Ma, Juan] Lanzhou Jiaotong Univ, Sch Environm & Municipal Engn, Lanzhou, Peoples R China. [Kapoor, Vikram; Domingo, Jorge Santo] US EPA, Cincinnati, OH 45268 USA. [McMahon, Katherine D.] Univ Wisconsin, Dept Bacteriol, Madison, WI 53706 USA. RP Noguera, DR (reprint author), 1415 Engn Dr, Madison, WI 53706 USA. EM camejo.pamela@gmail.com; browen92@gmail.com; joemartirano@gmail.com; megymma@163.com; Kapoor.Vikram@epa.gov; Santodomingo.jorge@epa.gov; trina.mcmahon@wisc.edu; noguera@engr.wisc.edu OI McMahon, Katherine D./0000-0002-7038-026X FU National Science Foundation [CBET-1435661, MCB-0738232]; Madison Metropolitan Sewerage District; Chilean National Commission for Scientific and Technological Research (CONICYT); U.S. Environmental Protection Agency (EPA); U.S. Environmental Protection Agency, through its Office of Research and Development FX This work was partially supported by funding from the National Science Foundation (CBET-1435661 and MCB-0738232) and the Madison Metropolitan Sewerage District. Additional funding from the Chilean National Commission for Scientific and Technological Research (CONICYT) as a fellowship to Pamela Camejo is also acknowledged. Vikram Kapoor was supported by U.S. Environmental Protection Agency (EPA) via a post-doctoral appointment administered by the Oak Ridge Institute for Science and Education. We thank Jaime Yanez, Jacqueline German, Jia Hui Khoo, Diana Barrera, Elizabeth Erb, Madeleine Haut, and Chloe Olson for support with laboratory analysis and reactor operation and Michael Elk for technical support during cloning experiments. The U.S. Environmental Protection Agency, through its Office of Research and Development, partially funded and collaborated in the research described herein. Any opinions expressed in this paper are those of the authors and do not necessarily reflect the views of the agency; therefore, no official endorsement should be inferred. Any mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 78 TC 2 Z9 2 U1 33 U2 41 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0043-1354 J9 WATER RES JI Water Res. PD OCT 1 PY 2016 VL 102 BP 125 EP 137 DI 10.1016/j.watres.2016.06.033 PG 13 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA DU1EG UT WOS:000381950400013 PM 27340814 ER PT J AU Chen, D Li, X Soule, T Yorio, F Orr, L AF Chen, Dong Li, Xuan Soule, Tanya Yorio, Francis Orr, Louisa TI Effects of solution chemistry on antimicrobial activities of silver nanoparticles against Gordonia sp SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Silver nanoparticles; Gordonia sp.; Inactivation; Surfactant; Natural organic matter; Silver chloride ID NATURAL ORGANIC-MATTER; AGGREGATION KINETICS; ANTIBACTERIAL ACTIVITY; COLLOIDAL STABILITY; ESCHERICHIA-COLI; PARTICLE-SIZE; DISSOLUTION; TOXICITY; WATER; BACTERIA AB Silver nanoparticles (NPs) are the largest and fastest growing category of nanotechnology-based medicines and consumer products. Silver can have great toxicity to some aquatic organisms and, as a biocidal agent, may also damage or alter the most abundant and vulnerable beneficial microorganisms in the environment, such as Gordonia sp. However, considering the complex chemical background of naturalwaters, silver NPs can have complicated interactions with background chemicals such as chloride, surfactants, and dissolved natural organic matters (NOM). The results of this study show that the average particle size and dispersivity of silver NPs and the surface characteristics play an important role in the toxicity of silver NPs. Aggregation was enhanced for silver NPs in 10 mM NaNO3, but not much in 10 mM NaCl due to reactions with chloride. However, the presence of 3 mM sodium dodecyl sulfate (SDS) or 8 mgC/L Suwannee River (SR) NOM appeared to reduce the aggregation of silver NPs. Regarding the bactericidal effect of silver NPs, solubility analysis suggests silver NPs inactivate Gordonia sp. differently from Ag+ and/or a slow release of Ag+ from silver NPs. When the silver NP concentration was raised from 7.3 to 29.2 mg/L in DI water, the log inactivation rate of Gordonia sp. increased from 0.16 +/- 0.04 to 0.45 +/- 0.13. However, with 29.2 mg/L silver NPs the log inactivation rate reached 1.40 +/- 0.26 in 3 mM SDS. The presence of SRNOM mitigated the bactericidal efficacy of silver NPs due to surface coating/adsorption. On the other hand, 10 mM NaCl reduced the log inactivation rate to 0.07 +/- 0.07 due to the formation of likely less toxic silver chloride species, such as AgCl, AgCl2-, AgCl32-, and AgCl43-. (C) 2016 Elsevier B.V. All rights reserved. C1 [Chen, Dong; Orr, Louisa] Indiana Univ Purdue Univ, Dept Civil & Mech Engn, 2101 E Coliseum Blvd, Ft Wayne, IN 46805 USA. [Li, Xuan] US EPA, ORISE Postdoctoral Participant, 26 W Martin Luther King Jr Dr, Cincinnati, OH 45268 USA. [Soule, Tanya; Yorio, Francis] Indiana Univ Purdue Univ, Dept Biol, 2101 E Coliseum Blvd, Ft Wayne, IN 46805 USA. RP Chen, D (reprint author), Indiana Univ Purdue Univ, Dept Civil & Mech Engn, 2101 E Coliseum Blvd, Ft Wayne, IN 46805 USA. EM chend@ipfw.edu FU US Geological Survey program through the Indiana Water Resources Research Center [104b]; Office of Research and External Support, Indiana University-Purdue University Fort Wayne FX This work was supported by the US Geological Survey 104b program through the Indiana Water Resources Research Center and the Office of Research and External Support, Indiana University-Purdue University Fort Wayne. We wish to thank Jordan Marshall for assistance with statistical analyses. This research has not been subjected to internal review of US EPA. Any opinions expressed in this paper are those of the authors and do not necessarily reflect the opinions of the authors' institutes. Any mention of products of trade name does not constitute recommendation for use. NR 53 TC 1 Z9 1 U1 14 U2 67 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD OCT 1 PY 2016 VL 566 BP 360 EP 367 DI 10.1016/j.scitotenv.2016.05.037 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA DS8VK UT WOS:000381060900038 PM 27228306 ER PT J AU Christiaen, B Lehrter, JC Goff, J Cebrian, J AF Christiaen, Bart Lehrter, John C. Goff, Joshua Cebrian, Just TI Functional implications of changes in seagrass species composition in two shallow coastal lagoons SO MARINE ECOLOGY PROGRESS SERIES LA English DT Article DE Ruppia maritima; Halodule wrightii; Seagrass; Species shift; Ecosystem metabolism ID GULF-OF-MEXICO; RUPPIA-MARITIMA L; HALODULE-WRIGHTII ASCHERS; ECOSYSTEM METABOLISM; FLORIDA BAY; ANTHROPOGENIC IMPACT; NUTRIENT ENRICHMENT; SEASONAL GROWTH; COMMUNITIES; ESTUARIES AB While the consequences of losing seagrass meadows are well known, there is less information on the functional implications of changes in seagrass species composition. In this study, we use data from a long-term monitoring project in shallow lagoons on the Florida Gulf Coast to assess changes in the functional attributes of seagrass beds during a shift in seagrass species composition. We compare seagrass beds in 2 neighboring lagoons with different trends: one where the composition changed from 100% Halodule wrightii to a mixed bed with up to 60% Ruppia maritima, and one where the species composition remained unchanged. Our results indicate that the partial replacement of H. wrightii by R. maritima did not alter seagrass biomass m(-2), detrital biomass m(-2), benthic gross primary production, or benthic respiration. However, there was a small positive effect on benthic net primary production. While seagrass biomass m(-2) declined at both sites, the emergence of R. maritima increased the amount of available habitat through rapid expansion. Overall, our data suggest that shifts between 2 seagrass species with similar morphology, but different ecological strategies, may have little impact on the ecosystem services of seagrass beds in shallow coastal lagoons. C1 [Christiaen, Bart] Washington State Dept Nat Resources, Olympia, WA 98504 USA. [Lehrter, John C.] US EPA, Gulf Ecol Div, Gulf Breeze, FL 32561 USA. [Goff, Joshua; Cebrian, Just] Dauphin Isl Sea Lab, Dauphin Isl, AL 36528 USA. [Cebrian, Just] Univ S Alabama, Mobile, AL 36608 USA. RP Christiaen, B (reprint author), Washington State Dept Nat Resources, Olympia, WA 98504 USA. EM bart.christiaen@dnr.wa.gov FU Department of Marine Sciences (University of South Alabama); NCDDC; NOAA National Coastal Data Development Center (NCDDC); Northern Gulf Institute FX We thank the many graduate students and interns who helped with data collection, in particular Jason Stutes, Ashley McDonald, Loren Marino, Sara Smith, Eric Sparks, and Shailesh Sharma. The NOAA National Coastal Data Development Center (NCDDC) and Northern Gulf Institute provided funding for this work. B.C. was supported with a graduate fellowship from the Department of Marine Sciences (University of South Alabama) and grants from NCDDC. Finally, we would like to thank the handling editor and 4 anonymous reviewers for their advice and helpful suggestions. NR 58 TC 0 Z9 0 U1 7 U2 7 PU INTER-RESEARCH PI OLDENDORF LUHE PA NORDBUNTE 23, D-21385 OLDENDORF LUHE, GERMANY SN 0171-8630 EI 1616-1599 J9 MAR ECOL PROG SER JI Mar. Ecol.-Prog. Ser. PD SEP 28 PY 2016 VL 557 BP 111 EP 121 DI 10.3354/meps11847 PG 11 WC Ecology; Marine & Freshwater Biology; Oceanography SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Oceanography GA EB1LR UT WOS:000387114000008 ER PT J AU Johnson, MG Andersen, CP Phillips, DL Kaldy, JE AF Johnson, Mark G. Andersen, Christian P. Phillips, Donald L. Kaldy, James E. TI Zostera marina root demography in an intertidal estuarine environment measured using minirhizotron technology SO MARINE ECOLOGY PROGRESS SERIES LA English DT Article DE Seagrass; Root turnover; Carbon dynamics; Root life span; Climate change; Pacific Northwest ID PONDEROSA PINE; ELEVATED CO2; THALASSIA-TESTUDINUM; ALLOCATION PATTERNS; SEAGRASS ECOSYSTEMS; HALODULE-WRIGHTII; N-FERTILIZATION; FINE ROOTS; CARBON; NITROGEN AB Over the last 4 decades there have been major advances in our understanding of the biology, ecology and physiology of seagrasses and their environmental interactions. Despite these advances, there has been relatively little advancement in our understanding of seagrass belowground dynamics. Minirhizotron tubes are a terrestrial ecology method used to visualize root birth, growth and death to evaluate root deployment, development and demography. Our objectives were to adapt the use of minirhizotrons in an intertidal seagrass bed, and to quantify root standing crop, production, mortality and life span of Zostera marina roots in a northwest US estuary. A total of 204 individual roots were observed and tracked over 18 monthly sampling periods. Roots exhibited marked vertical distribution in the sediment with peak root numbers at 9 and 25 cm depth. The median life span for roots deeper than 10 cm in the sediment was 75 d and only 48 d for roots in the top 10 cm of sediment. Root biomass turnover was estimated to be 56.9 g m(-2) yr(-1), while root carbon mass turnover estimate was 16.6 g C m(-2) yr(-1). Although significant logistical obstacles remain (e.g. minirhizotron use in subtidal beds), development of a non-destructive sampling technique for seagrass belowground root dynamics will provide better insight into seagrass root-sediment inter actions that cannot be captured using traditional destructive sampling methods. C1 [Johnson, Mark G.; Andersen, Christian P.; Phillips, Donald L.; Kaldy, James E.] US EPA, Natl Hlth & Environm Effects Res Lab, 200 SW 35th St, Corvallis, OR 97333 USA. RP Johnson, MG (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, 200 SW 35th St, Corvallis, OR 97333 USA. EM johnson.markg@epa.gov FU US Environmental Protection Agency FX The authors thank M. Storm, C. Folger and C. Mochon-Collura from Dynamac Inc. for technical assistance collecting root images in all kinds of weather and times of day. Special thanks are given to M. Storm for her help extracting root data from videos and organizing it in a way that simplified our analyses. We are also grateful to Dr. Pete Eldridge (deceased), who was instrumental in helping to develop this research path and for being a source of encouragement to the team conducting this work. We are also appreciative to those who have provided technical reviews of earlier versions of this manuscript and whose comments have improved it. The information in this document has been funded in part by the US Environmental Protection Agency. It has been subjected to review by the National Health and Environmental Effects Research Laboratory's Western Ecology Division and approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 50 TC 0 Z9 0 U1 2 U2 2 PU INTER-RESEARCH PI OLDENDORF LUHE PA NORDBUNTE 23, D-21385 OLDENDORF LUHE, GERMANY SN 0171-8630 EI 1616-1599 J9 MAR ECOL PROG SER JI Mar. Ecol.-Prog. Ser. PD SEP 28 PY 2016 VL 557 BP 123 EP 132 DI 10.3354/meps11867 PG 10 WC Ecology; Marine & Freshwater Biology; Oceanography SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Oceanography GA EB1LR UT WOS:000387114000009 ER PT J AU Gajdosechova, Z Lawan, MM Urgast, DS Raab, A Scheckel, KG Lombi, E Kopittke, PM Loeschner, K Larsen, EH Woods, G Brownlow, A Read, FL Feldmann, J Krupp, EM AF Gajdosechova, Zuzana Lawan, Mohammed M. Urgast, Dagmar S. Raab, Andrea Scheckel, Kirk G. Lombi, Enzo Kopittke, Peter M. Loeschner, Katrin Larsen, Erik H. Woods, Glenn Brownlow, Andrew Read, Fiona L. Feldmann, Jorg Krupp, Eva M. TI In vivo formation of natural HgSe nanoparticles in the liver and brain of pilot whales SO SCIENTIFIC REPORTS LA English DT Article ID MERCURY TOXICITY; INORGANIC MERCURY; RAINBOW-TROUT; SELENIUM; METHYLMERCURY; DETOXIFICATION; SPECIATION; ACCUMULATION; TRANSPORT; EXPOSURE AB To understand the biochemistry of methylmercury (MeHg) that leads to the formation of mercury-selenium (Hg-Se) clusters is a long outstanding challenge that promises to deepen our knowledge of MeHg detoxification and the role Se plays in this process. Here, we show that mercury selenide (HgSe) nanoparticles in the liver and brain of long-finned pilot whales are attached to Se-rich structures and possibly act as a nucleation point for the formation of large Se-Hg clusters, which can grow with age to over 5 mu m in size. The detoxification mechanism is fully developed from the early age of the animals, with particulate Hg found already in juvenile tissues. As a consequence of MeHg detoxification, Se-methionine, the selenium pool in the system is depleted in the efforts to maintain essential levels of Se-cysteine. This study provides evidence of so far unreported depletion of the bioavailable Se pool, a plausible driving mechanism of demonstrated neurotoxic effects of MeHg in the organism affected by its high dietary intake. C1 [Gajdosechova, Zuzana; Lawan, Mohammed M.; Urgast, Dagmar S.; Raab, Andrea; Feldmann, Jorg; Krupp, Eva M.] Univ Aberdeen, Dept Chem, Trace Element Speciat Lab, Meston Walk, Aberdeen AB24 3UE, Scotland. [Scheckel, Kirk G.] US EPA, Natl Risk Management Res Lab, 5995 Ctr Hill Ave, Cincinnati, OH 45224 USA. [Lombi, Enzo] Univ South Australia, Future Ind Inst, Bldg 10,Mawson Lakes Campus, Mawson Lakes, SA 5095, Australia. [Kopittke, Peter M.] Univ Queensland, Sch Agr & Food Sci, St Lucia, Qld 4072, Australia. [Loeschner, Katrin; Larsen, Erik H.] Tech Univ Denmark, Natl Food Inst, Morkhoj Bygade 19, DK-2860 Soborg, Denmark. [Woods, Glenn] Agilent Technol Ltd, 5500 Lakeside, Cheadle SK8 3GR, England. [Brownlow, Andrew] SAC Wildlife Unit, Inverness, Scotland. [Read, Fiona L.] Univ Aberdeen, Oceanlab, Main St, Newburgh AB41 6AA, Aberdeen, Scotland. RP Krupp, EM (reprint author), Univ Aberdeen, Dept Chem, Trace Element Speciat Lab, Meston Walk, Aberdeen AB24 3UE, Scotland. EM e.krupp@abdn.ac.uk RI Kopittke, Peter/A-6026-2011; OI Kopittke, Peter/0000-0003-4948-1880; Scheckel, Kirk/0000-0001-9326-9241; Feldmann, Joerg/0000-0002-0524-8254 FU College of Physical Sciences at University of Aberdeen; Chevron USA; Australian Research Council Future Fellowship [FT120100277]; EPA; Department of Energy; MRCAT; DOE Office of Science by Argonne National Laboratory [DE-AC02-06CH11357]; Marine Animal Stranding Scheme; Marine Scotland FX Z.G. thanks to the College of Physical Sciences at University of Aberdeen and Chevron USA for the provided studentship. P.M.K. is the recipient of an Australian Research Council Future Fellowship (FT120100277). Parts of this research were undertaken on the XFM beamline at the Australian Synchrotron, Victoria, Australia. The assistance of Daryl Howard (XFM beamline, Australian Synchrotron) is acknowledged. Although EPA contributed to this article, the research presented was not performed by or funded by EPA and was not subject to EPA's quality system requirements. Consequently, the views, interpretations, and conclusions expressed in this article are solely those of the authors and do not necessarily reflect or represent EPA's views or policies. MRCAT operations are supported by the Department of Energy and the MRCAT member institutions. This research used resources of the Advanced Photon Source, a U.S. Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under Contract No. DE-AC02-06CH11357. F.L.R. and A.B. acknowledge Scottish Marine Animal Stranding Scheme and Marine Scotland for funding. NR 56 TC 0 Z9 0 U1 19 U2 19 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD SEP 28 PY 2016 VL 6 AR 34361 DI 10.1038/srep34361 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DX1IG UT WOS:000384119600001 PM 27678068 ER PT J AU Sprovieri, F Pirrone, N Bencardino, M D'Amore, F Carbone, F Cinnirella, S Mannarino, V Landis, M Ebinghaus, R Weigelt, A Brunke, EG Labuschagne, C Martin, L Munthe, J Wangberg, I Artaxo, P Morais, F Barbosa, HDJ Brito, J Cairns, W Barbante, C Dieguez, MD Garcia, PE Dommergue, A Angot, H Magand, O Skov, H Horvat, M Kotnik, J Read, KA Neves, LM Gawlik, BM Sena, F Mashyanov, N Obolkin, V Wip, D Bin Feng, X Zhang, H Fu, XW Ramachandran, R Cossa, D Knoery, J Marusczak, N Nerentorp, M Norstrom, C AF Sprovieri, Francesca Pirrone, Nicola Bencardino, Mariantonia D'Amore, Francesco Carbone, Francesco Cinnirella, Sergio Mannarino, Valentino Landis, Matthew Ebinghaus, Ralf Weigelt, Andreas Brunke, Ernst-Gunther Labuschagne, Casper Martin, Lynwill Munthe, John Wangberg, Ingvar Artaxo, Paulo Morais, Fernando Jorge Barbosa, Henrique de Melo Brito, Joel Cairns, Warren Barbante, Carlo del Carmen Dieguez, Maria Elizabeth Garcia, Patricia Dommergue, Aurelien Angot, Helene Magand, Olivier Skov, Henrik Horvat, Milena Kotnik, Joze Read, Katie Alana Neves, Luis Mendes Gawlik, Bernd Manfred Sena, Fabrizio Mashyanov, Nikolay Obolkin, Vladimir Wip, Dennis Bin Feng, Xin Zhang, Hui Fu, Xuewu Ramachandran, Ramesh Cossa, Daniel Knoery, Joel Marusczak, Nicolas Nerentorp, Michelle Norstrom, Claus TI Atmospheric mercury concentrations observed at ground-based monitoring sites globally distributed in the framework of the GMOS network SO ATMOSPHERIC CHEMISTRY AND PHYSICS LA English DT Article ID GASEOUS ELEMENTAL MERCURY; MARINE BOUNDARY-LAYER; AMBIENT AIR; POLAR SUNRISE; ARCTIC-OCEAN; SOUTH-AFRICA; NY-ALESUND; MACE-HEAD; CHASING QUICKSILVER; SPECIATED MERCURY AB Long-term monitoring of data of ambient mercury (Hg) on a global scale to assess its emission, transport, atmospheric chemistry, and deposition processes is vital to understanding the impact of Hg pollution on the environment. The Global Mercury Observation System (GMOS) project was funded by the European Commission (http://www.gmos.eu) and started in November 2010 with the overall goal to develop a coordinated global observing system to monitor Hg on a global scale, including a large network of ground-based monitoring stations, ad hoc periodic oceanographic cruises and measurement flights in the lower and upper troposphere as well as in the lower stratosphere. To date, more than 40 ground-based monitoring sites constitute the global network covering many regions where little to no observational data were available before GMOS. This work presents atmospheric Hg concentrations recorded worldwide in the framework of the GMOS project (2010-2015), analyzing Hg measurement results in terms of temporal trends, seasonality and comparability within the network. Major findings highlighted in this paper include a clear gradient of Hg concentrations between the Northern and Southern hemispheres, confirming that the gradient observed is mostly driven by local and regional sources, which can be anthropogenic, natural or a combination of both. C1 [Sprovieri, Francesca; Bencardino, Mariantonia; D'Amore, Francesco; Carbone, Francesco; Cinnirella, Sergio; Mannarino, Valentino] CNR, Inst Atmospher Pollut, Arcavacata Di Rende, Italy. [Pirrone, Nicola] CNR, Inst Atmospher Pollut, Rome, Italy. [Landis, Matthew] US EPA, Off Res & Dev, Res Triangle Pk, NC USA. [Ebinghaus, Ralf; Weigelt, Andreas] Helmholtz Zentrum, Geesthacht, Germany. [Brunke, Ernst-Gunther; Labuschagne, Casper; Martin, Lynwill] South African Weather Serv, Climate & Environm Res & Monitoring, Cape Point GAW Stn, Stellenbosch, South Africa. [Munthe, John; Wangberg, Ingvar] Swedish Environm Res Inst Ltd, IVL, Gothenburg, Sweden. [Artaxo, Paulo; Morais, Fernando; Jorge Barbosa, Henrique de Melo; Brito, Joel] Univ Sao Paulo, Sao Paulo, Brazil. [Cairns, Warren; Barbante, Carlo] Univ Ca Foscari Venice, Venice, Italy. [Barbante, Carlo] CNR, Inst Dynam Environm Proc, Venice, Italy. [del Carmen Dieguez, Maria; Elizabeth Garcia, Patricia] INIBIOMA CONICET UNComa, San Carlos De Bariloche, Rio Negro, Argentina. [Dommergue, Aurelien; Angot, Helene; Magand, Olivier] Univ Grenoble Alpes, Lab Glaciol & Geophys Environm, Grenoble, France. [Dommergue, Aurelien; Angot, Helene; Magand, Olivier] CNRS, Lab Glaciol & Geophys Environm, Grenoble, France. [Skov, Henrik; Norstrom, Claus] Aarhus Univ, Dept Environm Sci, Aarhus, Denmark. [Horvat, Milena; Kotnik, Joze] Jozef Stefan Inst, Lubliana, Slovenia. [Read, Katie Alana] Univ York, NCAS, York, N Yorkshire, England. [Neves, Luis Mendes] INMG Sao Vicente, Cape Verde Observ, Sao Vicente, Cape Verde. [Gawlik, Bernd Manfred; Sena, Fabrizio] Joint Res Ctr, Ispra, Italy. [Mashyanov, Nikolay] St Petersburg State Univ, St Petersburg, Russia. [Obolkin, Vladimir] Limnol Inst SB RAS, Irkutsk, Russia. [Wip, Dennis] Univ Suriname, Dept Phys, Paramaribo, Surinam. [Bin Feng, Xin; Zhang, Hui; Fu, Xuewu] Chinese Acad Sci, State Key Lab Environm Geochem, Inst Geochem, Guiyang, Peoples R China. [Ramachandran, Ramesh] Anna Univ, Inst Ocean Management, Madras, Tamil Nadu, India. [Cossa, Daniel; Marusczak, Nicolas] IFREMER, LER PAC, Ctr Mediterranee, La Seyne Sur Mer, France. [Knoery, Joel] IFREMER, LBCM, Ctr Atlantique, Nantes, France. [Nerentorp, Michelle] Chalmers, Gothenburg, Sweden. RP Sprovieri, F (reprint author), CNR, Inst Atmospher Pollut, Arcavacata Di Rende, Italy. EM f.sprovieri@iia.cnr.it RI Feng, Xinbin/F-4512-2011; Brito, Joel/B-6181-2013; Artaxo, Paulo/E-8874-2010; Fu, xuewu/D-9137-2017; OI Feng, Xinbin/0000-0002-7462-8998; Brito, Joel/0000-0002-4420-9442; Artaxo, Paulo/0000-0001-7754-3036; knoery, joel/0000-0003-2826-6436; Skov, Henrik/0000-0003-1167-8696 FU European Commission [26511] FX The number of people and institutions to acknowledge for their great contribution during field studies is quite significant for a project like GMOS, but we greatly acknowledge the European Commission for funding GMOS as part of the FP7 (contract no. 26511). Special thanks to those research scientists and technicians that helped to set up aircraft-based platform for UTLS measurements, ground-based sites in remote locations including EV-K2 in Karakorum, Amsterdam Island and Dome C in Antarctica, and all those involved in GMOstral 1028 (IPEV) project for field logistics and technical support. NR 122 TC 6 Z9 6 U1 18 U2 18 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1680-7316 EI 1680-7324 J9 ATMOS CHEM PHYS JI Atmos. Chem. Phys. PD SEP 23 PY 2016 VL 16 IS 18 BP 11915 EP 11935 DI 10.5194/acp-16-11915-2016 PG 21 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA DX7DS UT WOS:000384547200007 ER PT J AU Pradeep, P Povinelli, RJ White, S Merrill, SJ AF Pradeep, Prachi Povinelli, Richard J. White, Shannon Merrill, Stephen J. TI An ensemble model of QSAR tools for regulatory risk assessment SO JOURNAL OF CHEMINFORMATICS LA English DT Article DE Computational toxicology; In silico QSAR tools; Hybrid QSAR models; Ensemble models; Risk assessment ID IN-SILICO; CLASSIFIER ENSEMBLES; MDL-QSAR; PREDICTION; TOXICOLOGY; PERFORMANCE; CONFIDENCE; AGREEMENT; LEADSCOPE; TOXICITY AB Quantitative structure activity relationships (QSARs) are theoretical models that relate a quantitative measure of chemical structure to a physical property or a biological effect. QSAR predictions can be used for chemical risk assessment for protection of human and environmental health, which makes them interesting to regulators, especially in the absence of experimental data. For compatibility with regulatory use, QSAR models should be transparent, reproducible and optimized to minimize the number of false negatives. In silico QSAR tools are gaining wide acceptance as a faster alternative to otherwise time-consuming clinical and animal testing methods. However, different QSAR tools often make conflicting predictions for a given chemical and may also vary in their predictive performance across different chemical datasets. In a regulatory context, conflicting predictions raise interpretation, validation and adequacy concerns. To address these concerns, ensemble learning techniques in the machine learning paradigm can be used to integrate predictions from multiple tools. By leveraging various underlying QSAR algorithms and training datasets, the resulting consensus prediction should yield better overall predictive ability. We present a novel ensemble QSAR model using Bayesian classification. The model allows for varying a cut-off parameter that allows for a selection in the desirable trade-off between model sensitivity and specificity. The predictive performance of the ensemble model is compared with four in silico tools (Toxtree, Lazar, OECD Toolbox, and Danish QSAR) to predict carcinogenicity for a dataset of air toxins (332 chemicals) and a subset of the gold carcinogenic potency database (480 chemicals). Leaveone- out cross validation results show that the ensemble model achieves the best trade-off between sensitivity and specificity (accuracy: 83.8 % and 80.4 %, and balanced accuracy: 80.6 % and 80.8 %) and highest inter-rater agreement [kappa (kappa): 0.63 and 0.62] for both the datasets. The ROC curves demonstrate the utility of the cut-off feature in the predictive ability of the ensemble model. This feature provides an additional control to the regulators in grading a chemical based on the severity of the toxic endpoint under study. C1 [Pradeep, Prachi] US EPA, Natl Ctr Computat Toxicol ORISE Fellow, Res Triangle Pk, NC 27711 USA. [Povinelli, Richard J.] Marquette Univ, Dept Elect & Comp Engn, Milwaukee, WI 53233 USA. [Merrill, Stephen J.] Marquette Univ, Dept Math Stat & Comp Sci, Milwaukee, WI 53233 USA. [White, Shannon] Georgetown Univ, Med Ctr, Lombardi Comprehens Canc Ctr, Washington, DC 20007 USA. RP Pradeep, P (reprint author), US EPA, Natl Ctr Computat Toxicol ORISE Fellow, Res Triangle Pk, NC 27711 USA. EM prachipradeep.15@gmail.com OI Pradeep, Prachi/0000-0002-9219-4249 FU US Department of Energy; US Food and Drug Administration FX This project was supported in part by an appointment to the Research Participation Program at the Center for Devices and Radiological Health administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and the US Food and Drug Administration. Sincere thanks to Ronald Brown (Toxicologist, CDRH) for his help in identification and development of the datasets used in this study and for his valuable suggestions in the development of this work. NR 40 TC 0 Z9 0 U1 9 U2 9 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1758-2946 J9 J CHEMINFORMATICS JI J. Cheminformatics PD SEP 22 PY 2016 VL 8 AR 48 DI 10.1186/s13321-016-0164-0 PG 9 WC Chemistry, Multidisciplinary; Computer Science, Information Systems; Computer Science, Interdisciplinary Applications SC Chemistry; Computer Science GA DW7LB UT WOS:000383831100001 PM 28316646 ER PT J AU Dagnino, S Strynar, MJ McMahen, RL Lau, CS Ball, C Garantziotis, S Webster, TF McClean, MD Lindstrom, AB AF Dagnino, Sonia Strynar, Mark J. McMahen, Rebecca L. Lau, Christopher S. Ball, Carol Garantziotis, Stavros Webster, Thomas F. McClean, Michael D. Lindstrom, Andrew B. TI Identification of Biomarkers of Exposure to FTOHs and PAPs in Humans Using a Targeted and Nontargeted Analysis Approach SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID PERFLUOROOCTANOIC ACID EXPOSURE; TANDEM MASS-SPECTROMETRY; POLYFLUOROALKYL SUBSTANCES; POLYFLUORINATED COMPOUNDS; CARBOXYLIC-ACIDS; OFFICE WORKERS; PERFLUOROALKYL; SAMPLES; URINE; AIR AB Although historic perfluorinated compounds are currently under scrutiny and growing regulatory control in the world, little is known about human exposure to other polyfluorinated compounds presently in use. Fluorotelomer alcohols (FTOHs) and polyfluoroalkyl phosphate esters (PAPs) are known to degrade to terminal perfluorinated acids and toxic reactive intermediates through metabolic pathways. Therefore, it is important to characterize their human exposure by the identification of unique biomarkers. With the use of liquid chromatography mass spectrometry-time-of-flight analysis (LC-MS-TOF), we developed a workflow for the identification of metabolites for the 8:2 FTOH and 8:2 diPAP. Analysis of serum and urine of dosed rats indicated the 8:2 FTOH sulfate and the 8:2 diPAP as potential biomarkers. These compounds, as well as 25 other fluorinated compounds and metabolites, were analyzed in human serum and urine samples from the general population (n = 100) and office workers (n = 30). The 8:2 FTOH sulfate was measured for the first time in human samples in 5 to 10% of the serum samples, ranging from 50 to 80 pg/mL. The 8:2 diPAP was measured in 58% of the samples, ranging from 100 to 800 pg/mL. This study indicates the FTOH sulfate conjugate as a biomarker of exposure to FTOHs and PAPs in humans. C1 [Dagnino, Sonia; Strynar, Mark J.; McMahen, Rebecca L.; Lindstrom, Andrew B.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Lau, Christopher S.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Dagnino, Sonia; McMahen, Rebecca L.] Oak Ridge Associated Univ, ORISE Program, Oak Ridge, TN 37831 USA. [Ball, Carol] Agilent Technol, 13000 Weston Pkwy, Cary, NC 27510 USA. [Garantziotis, Stavros] NIEHS, Clin Res Program, POB 12233, Res Triangle Pk, NC 27709 USA. [Garantziotis, Stavros] NIEHS, Lab Resp Biol, POB 12233, Res Triangle Pk, NC 27709 USA. [Webster, Thomas F.; McClean, Michael D.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, 715 Albany St,T4W, Boston, MA 02118 USA. RP Dagnino, S; Strynar, MJ (reprint author), US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.; Dagnino, S (reprint author), Oak Ridge Associated Univ, ORISE Program, Oak Ridge, TN 37831 USA. EM sonia.dagnino@ic.ac.uk; strynar.mark@epa.gov RI Garantziotis, Stavros/A-6903-2009 OI Garantziotis, Stavros/0000-0003-4007-375X FU Division of Intramural Research, National Institute of Environmental Health Sciences; [R01 ES015829] FX This research was partially supported by an appointment to the Research Participation Program at the National Exposure Research Laboratory administered by the Oak Ridge Institute for Science and Education. This research was also partially supported by funds from the Division of Intramural Research, National Institute of Environmental Health Sciences. We thank Agilent Technologies for their support of this effort through a TOFMS (U.S. EPA, CRADA 437-A-12) and in particular Joe Weitzel for his support of this work. We thank Imma Ferrer and Michael Thurman for training and advice on TOF MS. We also thank Matthew Stiegel for providing support on statistical analysis. M.D.M. and T.F.W. were supported in part by R01 ES015829. This article has been reviewed in accordance with the policy of the National Exposure Research Laboratory, U.S. Environmental Protection Agency, and approved for publication. NR 46 TC 1 Z9 1 U1 15 U2 17 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD SEP 20 PY 2016 VL 50 IS 18 BP 10216 EP 10225 DI 10.1021/acs.est.6b01170 PG 10 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA DX0FT UT WOS:000384037900049 PM 27477586 ER PT J AU Nacci, DE Hahn, ME Karchner, SI Jayaraman, S Mostello, C Miller, KM Blackwell, CG Nisbet, ICT AF Nacci, Diane E. Hahn, Mark E. Karchner, Sibel I. Jayaraman, Saro Mostello, Carolyn Miller, Kenneth M. Blackwell, Carma Gilchrist Nisbet, Ian C. T. TI Integrating Monitoring and Genetic Methods To Infer Historical Risks of PCBs and DDE to Common and Roseate Terns Nesting Near the New Bedford Harbor Superfund Site (Massachusetts, USA) SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID ARYL-HYDROCARBON RECEPTOR; TOXIC EQUIVALENCY FACTORS; DIOXIN-LIKE COMPOUNDS; STERNA-HIRUNDO; POLYCHLORINATED-BIPHENYLS; GREEN BAY; SPECIES-DIFFERENCES; SENSITIVITY; BIRDS; CONGENERS AB Common and roseate terns are migratory piscivorous seabirds with major breeding colonies within feeding range of the polychlorinated biphenyl (PCB)-contaminated New Bedford Harbor (NBH, MA, USA) Superfund site. Our longitudinal study shows that before PCB discharges into NBH ceased (late 1970s), tern eggs had very high but variable PCB concentrations. However, egg concentrations of PCBs as well as DDE (1,1-bis(p-chlorophenyl)-2,2-dichloroethene), the degradation product of the ubiquitous global contaminant DDT (1,1,1-trichloro-2,2-bis(p-chlorophenyl) ethane), have since declined. Rate constants for temporal decline of PCB congeners in tern eggs varied inversely with log(10)K(OW) (n-octanol-water partition coefficient), shifting egg congener patterns away from those characterizing NBH sediment. To estimate the toxic effects on tern eggs of PCB dioxin-like congener (DLC) exposures, we extrapolated published laboratory data on common terns to roseate terns by characterizing genetic and functional similarities in species aryl hydrocarbon receptors (AHRs), which mediate DLC sensitivity. Our assessment of contaminant risks suggests that terns breeding near NBH were exposed historically to toxic levels of PCBs and DDE; however, acute effects on tern egg development have become less likely since the 1970s. Our approach demonstrates how comparative genetics at target loci can effectively increase the range of inference for chemical risk assessments from tested to untested and untestable species. C1 [Nacci, Diane E.; Jayaraman, Saro] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA. [Hahn, Mark E.; Karchner, Sibel I.] Woods Hole Oceanog Inst, Dept Biol, Woods Hole, MA 02543 USA. [Mostello, Carolyn] Massachusetts Div Fisheries & Wildlife, 1 Rabbit Hill Rd, Westborough, MA 01591 USA. [Miller, Kenneth M.] CSRA LLC, 6361 Walker Lane,Suite 300, Alexandria, VA 22310 USA. [Blackwell, Carma Gilchrist] 9128 Haverstick Rd, Indianapolis, IN 46240 USA. [Nisbet, Ian C. T.] ICT Nisbet & Co, 150 Alder Lane, N Falmouth, MA 02556 USA. RP Nacci, DE (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA. EM Nacci.diane@epa.gov FU NOAA [NA14OAR4170074, R/P-80]; National Institute of Environmental Health Sciences (NIEHS) [P42ES007381] FX We thank Diana Franks (WHOI) for technical assistance. This work was supported in part by NOAA grant number NA14OAR4170074 (Woods Hole Sea Grant Project R/P-80) and by National Institute of Environmental Health Sciences (NIEHS) grant P42ES007381 (Superfund Basic Research Program at Boston University). This is tracking #ORD-015881 of the US Environmental Protection Agency, Office of Research and Development. This manuscript has been reviewed and approved for publication by the U.S. EPA. An early version of the manuscript benefitted greatly by reviews by Dr. Bryan Clark, Dr. Mark Cantwell, Dr. Barbara Bergen, and Mr. Joseph LiVolsi. Approval does not signify that the contents necessarily reflect the views and policies of the U.S EPA. Mention of trade names, products, or services does not convey and should not be interpreted as conveying official U.S. EPA approval, endorsement, or recommendation. NR 55 TC 0 Z9 0 U1 12 U2 12 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD SEP 20 PY 2016 VL 50 IS 18 BP 10226 EP 10235 DI 10.1021/acs.est.6b02108 PG 10 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA DX0FT UT WOS:000384037900050 PM 27564328 ER PT J AU Sluka, JP Fu, X Swat, M Belmonte, JM Cosmanescu, A Clendenon, SG Wambaugh, JF Glazier, JA AF Sluka, James P. Fu, Xiao Swat, Maciej Belmonte, Julio M. Cosmanescu, Alin Clendenon, Sherry G. Wambaugh, John F. Glazier, James A. TI A Liver-Centric Multiscale Modeling Framework for Xenobiotics SO PLOS ONE LA English DT Article ID BIOLOGY MARKUP LANGUAGE; HEPATIC STELLATE CELLS; IN-VIVO EXTRAPOLATION; SYSTEMS BIOLOGY; GLUTATHIONE METABOLISM; INDUCED HEPATOTOXICITY; ACETAMINOPHEN; PARACETAMOL; SIMULATION; HUMANS AB We describe a multi-scale, liver-centric in silico modeling framework for acetaminophen pharmacology and metabolism. We focus on a computational model to characterize whole body uptake and clearance, liver transport and phase I and phase II metabolism. We do this by incorporating sub-models that span three scales; Physiologically Based Pharmacokinetic (PBPK) modeling of acetaminophen uptake and distribution at the whole body level, cell and blood flow modeling at the tissue/organ level and metabolism at the sub-cellular level. We have used standard modeling modalities at each of the three scales. In particular, we have used the Systems Biology Markup Language (SBML) to create both the whole-body and sub-cellular scales. Our modeling approach allows us to run the individual sub-models separately and allows us to easily exchange models at a particular scale without the need to extensively rework the sub-models at other scales. In addition, the use of SBML greatly facilitates the inclusion of biological annotations directly in the model code. The model was calibrated using human in vivo data for acetaminophen and its sulfate and glucuronate metabolites. We then carried out extensive parameter sensitivity studies including the pairwise interaction of parameters. We also simulated population variation of exposure and sensitivity to acetaminophen. Our modeling framework can be extended to the prediction of liver toxicity following acetaminophen overdose, or used as a general purpose pharmacokinetic model for xenobiotics. C1 [Sluka, James P.; Fu, Xiao; Swat, Maciej; Belmonte, Julio M.; Cosmanescu, Alin; Clendenon, Sherry G.; Glazier, James A.] Indiana Univ Bloomington, Biocomplex Inst, Bloomington, IN 47405 USA. [Wambaugh, John F.] US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27711 USA. RP Sluka, JP; Glazier, JA (reprint author), Indiana Univ Bloomington, Biocomplex Inst, Bloomington, IN 47405 USA. EM JSluka@Indiana.edu; JGlazier@Indiana.edu RI Clendenon, Sherry/F-7651-2010; Belmonte, Julio/J-8696-2013 OI Clendenon, Sherry/0000-0002-3353-0919; Belmonte, Julio/0000-0002-4315-9631 FU US Environmental Protection Agency [R835001]; National Institute of Health, National Institute of General Medical Sciences [GM077138, GM111243]; Indiana University; Lilly Endowment; Indiana METACyt Initiative FX This research was funded by the US Environmental Protection Agency (www3.epa.gov), grant number R835001 (JAG, JFW, JPS, AC), The National Institute of Health, National Institute of General Medical Sciences (www.nih.gov), grant numbers GM077138 (JAG, JPS, MS, JMB) and GM111243 (JAG, JPS, XF, SGC), by Indiana University (www.indiana.edu) (JAG, XF, MS, JMB, AC, SGC), the Lilly Endowment (JAG), and Indiana METACyt Initiative (JAG). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 63 TC 2 Z9 2 U1 4 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD SEP 16 PY 2016 VL 11 IS 9 AR e0162428 DI 10.1371/journal.pone.0162428 PG 40 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DW5YN UT WOS:000383723700006 PM 27636091 ER PT J AU Rasool, QZ Zhang, R Lash, B Cohan, DS Cooter, EJ Bash, JO Lamsal, LN AF Rasool, Quazi Z. Zhang, Rui Lash, Benjamin Cohan, Daniel S. Cooter, Ellen J. Bash, Jesse O. Lamsal, Lok N. TI Enhanced representation of soil NO emissions in the Community Multiscale Air Quality (CMAQ) model version 5.0.2 SO GEOSCIENTIFIC MODEL DEVELOPMENT LA English DT Article ID NITRIC-OXIDE EMISSIONS; UNITED-STATES; AGRICULTURAL SOILS; NITROGEN-OXIDES; FERTILIZER APPLICATION; TILE DRAINAGE; N2O EMISSIONS; OMI; CHINA; CHEMISTRY AB Modeling of soil nitric oxide (NO) emissions is highly uncertain and may misrepresent its spatial and temporal distribution. This study builds upon a recently introduced parameterization to improve the timing and spatial distribution of soil NO emission estimates in the Community Multiscale Air Quality (CMAQ) model. The parameterization considers soil parameters, meteorology, land use, and mineral nitrogen (N) availability to estimate NO emissions. We incorporate daily year-specific fertilizer data from the Environmental Policy Integrated Climate (EPIC) agricultural model to replace the annual generic data of the initial parameterization, and use a 12 km resolution soil biome map over the continental USA. CMAQ modeling for July 2011 shows slight differences in model performance in simulating fine particulate matter and ozone from Interagency Monitoring of Protected Visual Environments (IMPROVE) and Clean Air Status and Trends Network (CASTNET) sites and NO2 columns from Ozone Monitoring Instrument (OMI) satellite retrievals. We also simulate how the change in soil NO emissions scheme affects the expected O-3 response to projected emissions reductions. C1 [Rasool, Quazi Z.; Zhang, Rui; Lash, Benjamin; Cohan, Daniel S.] Rice Univ, Dept Civil & Environm Engn, Houston, TX 77005 USA. [Cooter, Ellen J.; Bash, Jesse O.] US EPA, Computat Exposure Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Lamsal, Lok N.] Univ Space Res Assoc, Goddard Earth Sci Technol & Res, Columbia, MD 21046 USA. [Lamsal, Lok N.] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. [Lash, Benjamin] Univ Calif, Sch Nat Sci, Merced, CA USA. RP Cohan, DS (reprint author), Rice Univ, Dept Civil & Environm Engn, Houston, TX 77005 USA. EM cohan@rice.edu FU NASA's Air Quality Applied Sciences Team; Texas Air Quality Research Program FX This work was supported by NASA's Air Quality Applied Sciences Team through a tiger team project grant for DYNAMO: DYnamic Inputs of Natural Conditions for Air Quality Models and by the Texas Air Quality Research Program. NR 66 TC 0 Z9 0 U1 12 U2 12 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1991-959X EI 1991-9603 J9 GEOSCI MODEL DEV JI Geosci. Model Dev. PD SEP 16 PY 2016 VL 9 IS 9 BP 3177 EP 3197 DI 10.5194/gmd-9-3177-2016 PG 21 WC Geosciences, Multidisciplinary SC Geology GA DX4AL UT WOS:000384320000001 ER PT J AU Auerbach, DA Easton, ZM Walter, MT Flecker, AS Fuka, DR AF Auerbach, Daniel A. Easton, Zachary M. Walter, M. Todd Flecker, Alexander S. Fuka, Daniel R. TI Evaluating weather observations and the Climate Forecast System Reanalysis as inputs for hydrologic modelling in the tropics SO HYDROLOGICAL PROCESSES LA English DT Article DE precipitation; Soil and Water Assessment Tool; Climate Forecast System Reanalysis; Puerto Rico; tropical watershed modelling ID PUERTO-RICO; STREAMFLOW SIMULATION; PRECIPITATION DATA; LAND-COVER; SWAT; IMPACT; RAINFALL; PACKAGE; BASIN; AREA AB Correctly representing weather is critical to hydrological modelling, but scarce or poor quality observations can often compromise model accuracy. Reanalysis datasets may help to address this basic challenge. The Climate Forecast System Reanalysis (CFSR) dataset provides continuous, globally available records, and CFSR data have produced satisfactory hydrological model performance in some temperate and monsoonal locations. However, the use of CFSR for hydrological modelling in tropical and semi-tropical basins has not been adequately evaluated. Taking advantage of exceptionally high rainfall station density in the catchments of the Rio Grande de Loiza above San Juan, Puerto Rico, we compared model performance based on CFSR records with that based on publicly available weather stations in the Global Historical Climate Network (GHCN, n=21) and on a dataset of rainfall records maintained by the United States Geological Survey Caribbean Water Science Center (USGS, n=24). For an implementation of the Soil and Water Assessment Tool (SWAT) with subbasins defined at 11 streamflow gages, uncalibrated measures of Nash-Sutcliffe efficiency (NSE) were >0 at 8 of 11 gages using USGS precipitation data for daily simulations over the period 1998-2012, but were <0 using GHCN weather station records (8 of 11) and CFSR reanalysis data (9 of 11). Autocalibration of individual SWAT models for each of the 11 basins against each of the available weather datasets yielded NSE values>0 using all precipitation inputs, including CFSR. However, the ground weather station closest to the geographic basin centre produced the highest NSE values in only 5 of 11 cases. The spatially interpolated CFSR data performed as well or better than single ground observations made further than 20-30km, and sometimes better than individual weather stations <10km from the basin centroid. In addition to demonstrating the need to evaluate available weather inputs, this research reinforces the value of CFSR data as a means to supplement ground records and consistently determine a baseline for hydrologic model performance. Copyright (c) 2016 John Wiley & Sons, Ltd. C1 [Auerbach, Daniel A.; Flecker, Alexander S.] Cornell Univ, Dept Ecol & Evolutionary Biol, Ithaca, NY 14850 USA. [Easton, Zachary M.; Fuka, Daniel R.] Virginia Tech, Dept Biol Syst Engn, Blacksburg, VA USA. [Walter, M. Todd] Cornell Univ, Dept Biol & Environm Engn, Ithaca, NY USA. [Auerbach, Daniel A.] US EPA, Off Wetlands Oceans & Watersheds, Washington, DC 20004 USA. RP Auerbach, DA (reprint author), Cornell Univ, Dept Ecol & Evolutionary Biol, Ithaca, NY 14850 USA. EM da373@cornell.edu OI Auerbach, Daniel/0000-0002-3655-5206 FU Nature Conservancy's NatureNet; National Science Foundation [UCOR0009] FX The authors are grateful for several thoughtful reviews that strengthened the manuscript considerably. The USGS Caribbean Water Science Center deserves thanks and recognition for their hard work in maintaining valuable long-term data sources. DA is grateful for support from The Nature Conservancy's NatureNet post-doctoral fellowship program. Brian Buchanan provided helpful feedback, jovial wit and faultless espresso.; We would like to acknowledge high-performance computing support from Yellowstone (http://n2t.net/ark:/85065/d7wd3xhc) provided by NCAR's Computational and Information Systems Laboratory, sponsored by the National Science Foundation under project code UCOR0009, Analysis of Minimum Water Fund Investment Thresholds. NR 33 TC 2 Z9 2 U1 8 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0885-6087 EI 1099-1085 J9 HYDROL PROCESS JI Hydrol. Process. PD SEP 15 PY 2016 VL 30 IS 19 BP 3466 EP 3477 DI 10.1002/hyp.10860 PG 12 WC Water Resources SC Water Resources GA DW3US UT WOS:000383569200009 ER PT J AU Bradshaw, JK Snyder, BJ Oladeinde, A Spidle, D Berrang, ME Meinersmann, RJ Oakley, B Sidle, RC Sullivan, K Molina, M AF Bradshaw, J. Kenneth Snyder, Blake J. Oladeinde, Adelumola Spidle, David Berrang, Mark E. Meinersmann, Richard J. Oakley, Brian Sidle, Roy C. Sullivan, Kathleen Molina, Marirosa TI Characterizing relationships among fecal indicator bacteria, microbial source tracking markers, and associated waterborne pathogen occurrence in stream water and sediments in a mixed land use watershed SO WATER RESEARCH LA English DT Article DE Fecal indicator bacteria; Microbial source tracking markers; Recursive partitioning; Waterborne pathogens; Sediment ID REAL-TIME PCR; ESCHERICHIA-COLI; QUANTITATIVE PCR; FRESH-WATER; RIBOSOMAL-RNA; GENETIC-MARKERS; SURFACE WATERS; URBAN STREAM; SURVIVAL; CAMPYLOBACTER AB Bed sediments of streams and rivers may store high concentrations of fecal indicator bacteria (FIB) and pathogens. Due to resuspension events, these contaminants can be mobilized into the water column and affect overall water quality. Other bacterial indicators such as microbial source tracking (MST) markers, developed to determine potential sources of fecal contamination, can also be resuspended from bed sediments. The primary objective of this study was to predict occurrence of waterborne pathogens in water and streambed sediments using a simple statistical model that includes traditionally measured FIB, environmental parameters and source allocation, using MST markers as predictor variables. Synoptic sampling events were conducted during baseflow conditions downstream from agricultural (AG), forested (FORS), and wastewater pollution control plant (WPCP) land uses. Concentrations of FIB and MST markers were measured in water and sediments, along with occurrences of the enteric pathogens Campylobacter, Listeria and Salmonella, and the virulence gene that carries Shiga toxin, stx(2). Pathogens were detected in water more often than in underlying sediments. Shiga toxin was significantly related to land use, with concentrations of the ruminant marker selected as an independent variable that could correctly classify 76% and 64% of observed Shiga toxin occurrences in water and sediment, respectively. FIB concentrations and water quality parameters were also selected as independent variables that correctly classified Shiga toxin occurrences in water and sediment (54%-87%), and Salmonella occurrences in water (96%). Relationships between pathogens and indicator variables were generally inconsistent and no single indicator adequately described occurrence of all pathogens. Because of inconsistent relationships between individual pathogens and FIB/MST markers, incorporating a combination of FIB, water quality measurements, and MST markers may be the best way to assess microbial water quality in mixed land use systems. Published by Elsevier Ltd. C1 [Bradshaw, J. Kenneth; Snyder, Blake J.] Oak Ridge Inst Sci & Educ, POB 117, Oak Ridge, TN 37831 USA. [Bradshaw, J. Kenneth; Snyder, Blake J.; Oladeinde, Adelumola; Spidle, David; Sullivan, Kathleen; Molina, Marirosa] US EPA, Ecosyst Res Div, Off Res & Dev, Natl Exposure Res Lab, 960 Coll Stn RD, Athens, GA 30605 USA. [Berrang, Mark E.; Meinersmann, Richard J.] USDA ARS, 950 Coll Stn RD, Athens, GA 30605 USA. [Sidle, Roy C.] Univ Sunshine Coast, Sustainabil Res Ctr, 90 Sippy Downs Dr, Sippy Downs, Qld 4556, Australia. [Oakley, Brian] Western Univ Hlth Sci, Coll Vet Med, 309 E 2nd SC, Pomona, CA 91711 USA. RP Molina, M (reprint author), US EPA, Ecosyst Res Div, Off Res & Dev, Natl Exposure Res Lab, 960 Coll Stn RD, Athens, GA 30605 USA. EM molina.marirosa@epa.gov NR 67 TC 4 Z9 4 U1 39 U2 40 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0043-1354 J9 WATER RES JI Water Res. PD SEP 15 PY 2016 VL 101 BP 498 EP 509 DI 10.1016/j.watres.2016.05.014 PG 12 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA DT0JI UT WOS:000381169400051 PM 27295624 ER PT J AU Geron, CD Daly, RW Arnts, RR Guenther, AB Mowry, FL AF Geron, Christopher D. Daly, Ryan W. Arnts, Robert R. Guenther, Alex B. Mowry, Fred L. TI Canopy level emissions of 2-methyl-3-buten-2-ol, monoterpenes, and sesquiterpenes from an experimental Pinus taeda plantation SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Pinus taeda; Methyl butenol; Monoterpenes; Sesquiterpenes; Biogenic Volatile Organic Compound; Model of Emissions of Gases and Aerosols from Nature (MEGAN) ID VOLATILE ORGANIC-COMPOUNDS; RELAXED EDDY ACCUMULATION; LOBLOLLY-PINE; ISOPRENE EMISSIONS; UNITED-STATES; FOREST; FLUXES; MODEL; AEROSOL; ATMOSPHERE AB Emissions of Biogenic Volatile Organic Compounds (BVOCs) observed during 2007 from an experimental Pinus taeda plantation in Central North Carolina are compared with model estimates from the Model of Emissions of Gases and Aerosols from Nature (MEGAN) version 2.1. Relaxed eddy accumulation (REA) estimates of 2methyl-3-buten-2-ol (MBO) fluxes are a factor of 3-4 higher than MEGAN estimates. MEGAN monoterpene emission estimates were a factor of approximately two higher than REA flux measurements. MEGAN beta-caryophyllene emission estimates were within 60% of growing season REA flux estimates but were several times higher than REA fluxes during cooler, dormant season periods. The sum of other sesquiterpene emissions estimated by MEGAN was several times higher than REA estimates throughout the year. Model components are examined to understand these discrepancies. Measured summertime leaf area index (LAI) (and therefore foliar biomass) is a factor of two higher than assumed in MEGAN for the P. taeda default. Increasing the canopy mean MBO emission factor from 0.35 to 1.0 mg m(-2) h(-1) also reduces MEGAN vs. REA flux differences. This increase is within current MBO emission factor uncertainties. The algorithm within MEGAN which adjusts isoprene emission estimates as a function of the temperature and light of the previous 24 h seems also to improve the seasonal MEGAN MBO correlation with REA fluxes. Including the effects of the previous 240 h, however, seems to degrade temporal model correlation with fluxes. Monoterpene and sesquiterpene composition data from the REA are compared with MEGAN2.1 estimates and also branch enclosure and needle extract data collected at this site. To our knowledge, the flux data presented here are the first reported for MBO and sesquiterpenes from a P. taeda ecosystem. Published by Elsevier B.V. C1 [Geron, Christopher D.; Daly, Ryan W.] US EPA, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. [Arnts, Robert R.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Guenther, Alex B.] Univ Calif Irvine, Irvine, CA 92697 USA. [Mowry, Fred L.] Duke Univ, Nicholas Sch Environm & Earth Sci, Durham, NC 27708 USA. RP Geron, CD (reprint author), US EPA, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. EM Geron.chris@epa.gov; Daly.ryan@epa.gov; Alex.Guenther@uci.edu FU U.S. Department of Energy [DE-AC02-98CH10886, DE-FG02-95ER62083]; Office of Science (BER) FX This research was supported by the Office of Science (BER), U.S. Department of Energy, Grant No. DE-FG02-95ER62083. Meteorological data were obtained under the U.S. Department of Energy Contract No. DE-AC02-98CH10886 with Brookhaven National Laboratory. The United States Environmental Protection Agency produced the research described here. It has been subjected to Agency's administrative review and approved for publication. NR 46 TC 0 Z9 0 U1 11 U2 26 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD SEP 15 PY 2016 VL 565 BP 730 EP 741 DI 10.1016/j.scitotenv.2016.05.034 PG 12 WC Environmental Sciences SC Environmental Sciences & Ecology GA DP0UV UT WOS:000378206300075 PM 27232720 ER PT J AU Henderson, WM Bouchard, D Chang, XJ Al-Abed, SR Teng, Q AF Henderson, W. Matthew Bouchard, Dermont Chang, Xiaojun Al-Abed, Souhail R. Teng, Quincy TI Biomarker analysis of liver cells exposed to surfactant-wrapped and oxidized multi-walled carbon nanotubes (MWCNTs) SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Carbon nanotubes; MWCNT suspension; Biomarker profiling; Metabolomics; Liver toxicity ID GRAPHENE OXIDE; IN-VITRO; CYTOTOXICITY; METABOLOMICS; TOXICITY; PRISTINE; BIOCOMPATIBILITY; PULMONARY; PROTEINS; ACID AB Carbon nanotubes (CNTs) have great potential in industrial, consumer, and mechanical applications, based partly on their unique structural, optical and electronic properties. CNTs are commonly oxidized or treated with surfactants to facilitate aqueous solution processing, and these CNT surface modifications also increase possible human and ecological exposures to nanoparticle-contaminated waters. To determine the exposure outcomes of oxidized and surfactant-wrapped multiwalled carbon nanotubes (MWCNTs) on biochemical processes, metabolomicsbased profiling of human liver cells (C3A) was utilized. Cells were exposed to 0, 10, or 100 ng/mL of MWCNTs for 24 and 48 h; MWCNT particle size distribution, charge, and aggregation were monitored concurrently during exposures. Following MWCNT exposure, cellular metabolites were extracted, lyophilized, and buffered for H-1 NMR analysis. Acquired spectra were subjected to both multivariate and univariate analysis to determine the consequences of nanotube exposure on themetabolite profile of C3A cells. Resulting scores plots illustrated temporal and dose-dependent metabolite responses to all MWCNTs tested. Loadings plots coupled with t-test filtered spectra identified metabolites of interest. XPS analysis revealed the presence of hydroxyl and carboxyl functionalities on both MWCNTs surfaces. Metal content analysis by ICP-AES indicated that the total mass concentration of the potentially toxic impurities in the exposure experiments were extremely low (i.e. [Ni] <= 2 x 10(-10) g/mL). Preliminary data suggested that MWCNT exposure causes perturbations in biochemical processes involved in cellular oxidation as well as fluxes in amino acid metabolism and fatty acid synthesis. Dose-response trajectories were apparent and spectral peaks related to both dose and MWCNT dispersionmethodologies were determined. Correlations of the significant changes in metabolites will help to identify potential biomarkers associated with carbonaceous nanoparticle exposure. Published by Elsevier B.V. C1 [Henderson, W. Matthew; Bouchard, Dermont; Teng, Quincy] US EPA, Off Res & Dev, Natl Exposure Res Lab, 960 Coll Stn Rd, Athens, GA 30605 USA. [Chang, Xiaojun] US EPA, Natl Res Council Cooperat Agreement, Athens, GA 30605 USA. [Al-Abed, Souhail R.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, 26 Martin Luther King Dr W, Cincinnati, OH 45268 USA. RP Henderson, WM (reprint author), US EPA, ORD, NERL, ERD, 960 Coll Stn Rd, Athens, GA 30605 USA. EM Henderson.Matt@epa.gov NR 44 TC 1 Z9 1 U1 25 U2 74 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD SEP 15 PY 2016 VL 565 BP 777 EP 786 DI 10.1016/j.scitotenv.2016.05.025 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA DP0UV UT WOS:000378206300079 PM 27216968 ER PT J AU Pennino, MJ McDonald, RI Jaffe, PR AF Pennino, Michael J. McDonald, Rob I. Jaffe, Peter R. TI Watershed-scale impacts of stormwater green infrastructure on hydrology, nutrient fluxes, and combined sewer overflows in the mid-Atlantic region SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Urban; Stormwater management; Hydrologic flashiness; Nitrogen exports; Phosphorus exports; Water quality ID FLOW CONSTRUCTED WETLANDS; LIFE-CYCLE ASSESSMENT; URBAN STREAM SYNDROME; MANAGEMENT-PRACTICES; CLIMATE VARIABILITY; PHOSPHORUS REMOVAL; FIELD PERFORMANCE; NORTH-CAROLINA; UNITED-STATES; URBANIZATION AB Stormwater green infrastructure (SGI), including rain gardens, detention ponds, bioswales, and green roofs, is being implemented in cities across the globe to reduce flooding, combined sewer overflows, and pollutant transport to streams and rivers. Despite the increasing use of urban SGI, few studies have quantified the cumulative effects of multiple SGI projects on hydrology and water quality at the watershed scale. To assess the effects of SGI, Washington, DC, Montgomery County, MD, and Baltimore County, MD, were selected based on the availability of data on SGI, water quality, and stream flow. The cumulative impact of SGI was evaluated over space and time by comparing watersheds with and without SGI, and by assessing how long-term changes in SGI impact hydrologic and water quality metrics over time. Most Mid-Atlantic municipalities have a goal of achieving 10-20% of the landscape drain runoff through SGI by 2030. Of these areas, Washington, DC currently has the greatest amount of SGI (12.7% of the landscape drained through SGI), while Baltimore County has the lowest (7.9%). When controlling for watersheds size and percent impervious surface cover, watersheds with greater amounts of SGI have less flashy hydrology, with 44% lower peak runoff, 26% less frequent runoff events, and 26% less variable runoff. Watersheds with more SGI also show 44% less NO3- and 48% less total nitrogen exports compared to watersheds with minimal SGI. There was no significant reduction in phosphorus exports or combined sewer overflows in watersheds with greater SGI. When comparing individual watersheds over time, increases in SGI corresponded to non-significant reductions in hydrologic flashiness compared to watersheds with no change in SGI. While the implementation of SGI is somewhat in its infancy in some regions, cities are beginning to have a scale of SGI where there are statistically significant differences in hydrologic patterns and water quality. (C) 2016 The Authors. Published by Elsevier B.V. C1 [Pennino, Michael J.; Jaffe, Peter R.] Princeton Univ, Dept Civil & Environm Engn, Princeton, NJ 08544 USA. [McDonald, Rob I.] Nature Conservancy, Global Cities Program, 1815 N Lynn St, Arlington, VA USA. RP Pennino, MJ (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR 97333 USA. EM michael.pennino@gmail.com FU NatureNet Science Fellowship Program FX The NatureNet Science Fellowship Program provided funding for this research through a generous donation to The Nature Conservancy. We would like to thank Jim Smith and Mary Lynn Baeck at Princeton University for providing rainfall data; Jason Cruz, Matt Fritch, and Mary Ellen McCarty at the Philadelphia Water Department for providing water quality and GIS data; Bethany Bezak at District of Columbia Water and Sewer Authority for providing GIS data; Scott Faunce and Sarah Ramirez at Montgomery Department of Environmental Protection for GIS data on SGI in Montgomery County, MD; and Steve Stewart from the Baltimore County Department of Environment and Sustainability for GIS data on SGI locations in Baltimore County. NR 90 TC 2 Z9 2 U1 91 U2 178 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD SEP 15 PY 2016 VL 565 BP 1044 EP 1053 DI 10.1016/j.scitotenv.2016.05.101 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA DP0UV UT WOS:000378206300109 PM 27261425 ER PT J AU Ge, Y Bruno, M Haykal-Coates, N Wallace, K Andrews, D Swank, A Winnik, W Ross, JA AF Ge, Yue Bruno, Maribel Haykal-Coates, Najwa Wallace, Kathleen Andrews, Debora Swank, Adam Winnik, Witold Ross, Jeffrey A. TI Proteomic Assessment of Biochemical Pathways That Are Critical to Nickel-Induced Toxicity Responses in Human Epithelial Cells SO PLOS ONE LA English DT Article ID ACUTE LUNG INJURY; 14-3-3 PROTEINS; DNA-REPAIR; EXPRESSION; HYPOXIA; CANCER; METALLOTHIONEIN; CARCINOGENICITY; INTERFERENCE; FIBROBLASTS AB Understanding the mechanisms underlying toxicity initiated by nickel, a ubiquitous environmental contaminant and known human carcinogen is necessary for proper assessment of its risks to human and environment. Among a variety of toxic mechanisms, disruption of protein responses and protein response-based biochemical pathways represents a key mechanism through which nickel induces cytotoxicity and carcinogenesis. To identify protein responses and biochemical pathways that are critical to nickel-induced toxicity responses, we measured cytotoxicity and changes in expression and phosphorylation status of 14 critical biochemical pathway regulators in human BEAS-2B cells exposed to four concentrations of nickel using an integrated proteomic approach. A subset of the pathway regulators, including interleukin-6, and JNK, were found to be linearly correlated with cell viability, and may function as molecular determinants of cytotoxic responses of BEAS-2B cells to nickel exposures. In addition, 128 differentially expressed proteins were identified by two dimensional electrophoresis (2-DE) and mass spectrometry. Principal component analysis, hierarchical cluster analyses, and ingenuity signaling pathway analysis (IPA) identified putative nickel toxicity pathways. Some of the proteins and pathways identified have not previously been linked to nickel toxicity. Based on the consistent results obtained from both ELISA and 2-DE proteomic analysis, we propose a core signaling pathway regulating cytotoxic responses of human BEAS-2B cells to nickel exposures, which integrates a small set of proteins involved in glycolysis and gluconeogenesis pathways, apoptosis, protein degradation, and stress responses including inflammation and oxidative stress. C1 [Ge, Yue; Bruno, Maribel; Haykal-Coates, Najwa; Wallace, Kathleen; Andrews, Debora; Swank, Adam; Winnik, Witold; Ross, Jeffrey A.] US EPA, Natl Hlth & Environm Effects Res Lab, Durham, NC USA. RP Ge, Y (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Durham, NC USA. EM Ge.Yue@epa.gov RI Ross, Jeffrey/E-4782-2010 OI Ross, Jeffrey/0000-0002-7002-4548 FU US Environmental Protection Agency; Pathfinder Innovation Project (PIP) from Office of Research and Development (ORD), US Environmental Protection Agency FX The research was funded by Pathfinder Innovation Project from US Environmental Protection Agency.; This research was supported by the Pathfinder Innovation Project (PIP) from Office of Research and Development (ORD), US Environmental Protection Agency. The authors also would like to thank Drs. Sheau-Fung Thai, Aimen Farraj, and Charlene McQueen for their very helpful comments on this manuscript, and Alan Tennant for his assistance on the apoptosis imaging. The information in this document has been funded wholly by the US Environmental Protection Agency. It has been subjected to review by the National Health and Environmental Effects Research Laboratory and approved for publication. Approval does not signify that the contents reflect the views of the Agency nor doesmention of trade names or commercial products constitute endorsement or recommendation for use. NR 40 TC 0 Z9 0 U1 1 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD SEP 14 PY 2016 VL 11 IS 9 AR e0162522 DI 10.1371/journal.pone.0162522 PG 20 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DW5JO UT WOS:000383680600040 PM 27626938 ER PT J AU Kholod, N Evans, M Kuklinski, T AF Kholod, Nazar Evans, Meredydd Kuklinski, Teresa TI Russia's black carbon emissions: focus on diesel sources SO ATMOSPHERIC CHEMISTRY AND PHYSICS LA English DT Article ID VEHICLES; PROJECTIONS; AEROSOLS; SNOW AB Black carbon (BC) is a significant climate forcer with a particularly pronounced forcing effect in polar regions such as the Russian Arctic. Diesel combustion is a major global source of BC emissions, accounting for 25-30% of all BC emissions. While the demand for diesel is growing in Russia, the country's diesel emissions are poorly understood. This paper presents a detailed inventory of Russian BC emissions from diesel sources. Drawing on a complete Russian vehicle registry with detailed information about vehicle types and emission standards, this paper analyzes BC emissions from diesel on-road vehicles. We use the COPERT emission model (COmputer Programme to calculate Emissions from Road Transport) with Russia-specific emission factors for all types of on-road vehicles. On-road diesel vehicles emitted 21 Gg of BC in 2014: heavy-duty trucks account for 60% of the on-road BC emissions, while cars represent only 5% (light commercial vehicles and buses account for the remainder). Using Russian activity data and fuel-based emission factors, the paper also presents BC emissions from diesel locomotives and ships, off-road engines in industry, construction and agriculture, and generators. The study also factors in the role of superemitters in BC emissions from diesel on-road vehicles and off-road sources. The total emissions from diesel sources in Russia are estimated to be 49 Gg of BC and 17 Gg of organic carbon (OC) in 2014. Off-road diesel sources emitted 58% of all diesel BC in Russia. C1 [Kholod, Nazar; Evans, Meredydd] Pacific Northwest Natl Lab, Joint Global Change Res Inst, 5825 Univ Res Court,Suite 3500, College Pk, MD 20740 USA. [Kuklinski, Teresa] US EPA, Off Int & Tribal Affairs, 1200 Penn Ave NW, Washington, DC 20460 USA. RP Kholod, N (reprint author), Pacific Northwest Natl Lab, Joint Global Change Res Inst, 5825 Univ Res Court,Suite 3500, College Pk, MD 20740 USA. EM nazar.kholod@pnnl.gov FU US Environmental Protection Agency, Office of International and Tribal Affairs [DW-089924383]; US Department of State; US Department of Energy [DE-AC05-76RL01831] FX The authors are grateful for research support provided by the US Environmental Protection Agency, Office of International and Tribal Affairs (under the inter-agency agreement DW-089924383), and the US Department of State. Battelle Memorial Institute operates the Pacific Northwest National Laboratory for the US Department of Energy under contract DE-AC05-76RL01831. We thank the members of the Technical Steering Group for their helpful comments and suggestions. NR 83 TC 1 Z9 1 U1 5 U2 5 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1680-7316 EI 1680-7324 J9 ATMOS CHEM PHYS JI Atmos. Chem. Phys. PD SEP 12 PY 2016 VL 16 IS 17 DI 10.5194/acp-16-11267-2016 PG 15 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA DX2KZ UT WOS:000384199700001 ER PT J AU Ingwersen, W Gausman, M Weisbrod, A Sengupta, D Lee, SJ Bare, J Zanoli, E Bhander, GS Ceja, M AF Ingwersen, Wesley Gausman, Maria Weisbrod, Annie Sengupta, Debalina Lee, Seung-Jin Bare, Jane Zanoli, Ed Bhander, Gurbakash S. Ceja, Manuel TI Detailed life cycle assessment of Bounty (R) paper towel operations in the United States SO JOURNAL OF CLEANER PRODUCTION LA English DT Article DE Consumer product; Paper towel; Sustainability metrics; Sustainability indicators; Life cycle assessment; Life cycle impact assessment ID INTEGRATED METRICS; DECISION-MAKING; SUSTAINABILITY; FOOTPRINT; PHASE; LCA AB Life Cycle Assessment (LCA) is a well-established and informative method of understanding the environmental impacts of consumer products across the entire value chain. However, companies committed to sustainability are interested in more methods that examine their products and activities' impacts. Methods that build on LCA strengths and illuminate other connected but less understood facets, related to social and economic impacts, would provide greater value to decision-makers. This study is a LCA that calculates the potential impacts associated with Bounty paper towels from two facilities with different production lines, an older one (Albany, Georgia) representing established technology and the other (Box Elder, Utah), a newer state-of-the-art platform. This is unique in that it includes use of Industrial Process Systems Assessment (IPSA), new electricity and pulp data, modeled in open source software, and is the basis for the development of new integrated sustainability metrics (published separately). The new metrics can guide supply chain and manufacturing enhancements, and product design related to environmental protection and resource sustainability. Results of the LCA indicate Box Elder had improvements on environmental impact scores related to air emission indicators, except for particulate matter. Albany had lower water use impacts. After normalization of the results, fossil fuel depletion is the most critical environmental indicator. Pulp production, electricity, and fuels for product production drive fossil fuel depletion. Climate change, land occupation, and particulate matter are also relevant. Greenhouse gas (GHG) emissions by pulp, electricity, papermaking, and landfill methane from the disposed product, drive climate change impacts. Pulp provides significant offsets to balance climate change impacts due to sequestration of atmospheric carbon dioxide. Ninety-nine percent of land occupation is for the growth of the trees for pulp production. Papermaking, electricity, and pulp production cause the most potential particular matter formation. (C) 2016 The Author(s). Published by Elsevier Ltd. C1 [Ingwersen, Wesley; Sengupta, Debalina; Lee, Seung-Jin; Bare, Jane; Bhander, Gurbakash S.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45238 USA. [Gausman, Maria; Weisbrod, Annie; Zanoli, Ed; Ceja, Manuel] Procter & Gamble Co, Global Prod Stewardship & Prod Supply, Cincinnati, OH 45224 USA. [Sengupta, Debalina] Texas A&M Univ, Artie McFerrin Dept Chem Engn, College Stn, TX 77843 USA. [Lee, Seung-Jin] Univ Michigan, Dept Earth & Resource Sci, Flint, MI 48502 USA. RP Gausman, M (reprint author), Procter & Gamble Co, Global Prod Stewardship & Prod Supply, Cincinnati, OH 45224 USA. EM gausman.mm@pg.com NR 64 TC 0 Z9 0 U1 24 U2 31 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0959-6526 EI 1879-1786 J9 J CLEAN PROD JI J. Clean Prod. PD SEP 10 PY 2016 VL 131 BP 509 EP 522 DI 10.1016/j.jclepro.2016.04.149 PG 14 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental; Environmental Sciences SC Science & Technology - Other Topics; Engineering; Environmental Sciences & Ecology GA DQ5UP UT WOS:000379270900050 ER PT J AU Heinrichs, JA Bender, DJ Schumaker, NH AF Heinrichs, Julie A. Bender, Darren J. Schumaker, Nathan H. TI Habitat degradation and loss as key drivers of regional population extinction SO ECOLOGICAL MODELLING LA English DT Article DE Extinction; Fragmentation; Habitat degradation; Habitat loss; Habitat quality; Simulation ID RELATIVE IMPORTANCE; METAPOPULATION DYNAMICS; FRAGMENTATION; QUALITY; LANDSCAPE; MODELS; BIRDS; SIZE; AREA; HETEROGENEITY AB Habitat quality is a fundamental driver of species distributions and population outcomes but is often difficult to measure and compare alongside measures of habitat amount and fragmentation. Consequently, habitat quality is often omitted from many landscape-level habitat analyses or more indirectly or subjectively represented in resulting habitat management or conservation planning. Yet, the implications of this conceptual and planning omission are poorly understood. We lack general theory that identifies the conditions under which habitat quality is expected to play a vital role in characterizing local and regional population responses. Using a factorial simulation design, we examined the independent contributions of habitat quality, amount, and fragmentation to population persistence to identify the conditions under which habitat quality might be expected to play a more important role than those of habitat amount or fragmentation. We generated a wide range of fractal landscapes, independently varying in habitat amount, fragmentation, and quality in QRule. We simulated interactive animal movement, habitat selection, and persistence for r and K strategist species with short and long dispersal abilities using spatially explicit individual-based models developed in HexSim. Population abundance and extinction risk were recorded through time for each landscape-species combination and used to quantify the relative influence of habitat amount, fragmentation, and landscape quality on population outcomes. We found that habitat degradation influenced extinction risk through a wide range of landscape conditions and species attributes. The most severe extinction responses were observed in scenarios of combined habitat loss and degradation, suggesting that the interactive effects of these variables may greatly affect persistence. Landscape quality modified extinction risks associated with habitat amount-fragmentation thresholds, and we found evidence for quality-based extinction thresholds as habitat was degraded. The strength of landscape-level quality on extinction risk outcomes suggests that habitat degradation should be further investigated as a major driver of population responses to landscape change. A more inclusive paradigm may be required to elucidate the general influences landscape change on population extinction. Habitat degradation, along with habitat loss and fragmentation, should be explicitly considered when assessing the implications of landscape change on population extinction. (C) 2016 Elsevier B.V. All rights reserved. C1 [Heinrichs, Julie A.] Univ Calgary, Dept Biol Sci, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada. [Bender, Darren J.] Univ Calgary, Dept Geog, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada. [Schumaker, Nathan H.] US EPA, Western Ecol Div, 200 SW 35th St, Corvallis, OR 97333 USA. [Heinrichs, Julie A.] Colorado State Univ, Nat Resource Ecol Lab, Ft Collins, CO USA. RP Heinrichs, JA (reprint author), Univ Calgary, Dept Biol Sci, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada.; Heinrichs, JA (reprint author), Colorado State Univ, Nat Resource Ecol Lab, Ft Collins, CO USA. EM Julie.Heinrichs@colostate.edu; darren.bender@ucalgary.ca; schumaker.nathan@epa.gov RI Heinrichs, Julie/D-2927-2016 OI Heinrichs, Julie/0000-0001-7733-5034 FU University of Calgary; U.S. Environmental Protection Agency FX This research was supported by the University of Calgary. The information in this document has been funded in part by the U.S. Environmental Protection Agency. It has been subjected to review by the National Health and Environmental Effects Research Laboratory's Western Ecology Division and approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. We thank A. Sidder for modeling assistance. NR 45 TC 0 Z9 0 U1 49 U2 104 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3800 EI 1872-7026 J9 ECOL MODEL JI Ecol. Model. PD SEP 10 PY 2016 VL 335 BP 64 EP 73 DI 10.1016/j.ecolmode1.2016.05.009 PG 10 WC Ecology SC Environmental Sciences & Ecology GA DQ3MF UT WOS:000379105700008 ER PT J AU Teeguarden, JG Tan, YM Edwards, SW Leonard, JA Anderson, KA Corley, RA Kile, ML Simonich, SLM Stone, D Tanguay, RL Waters, KM Harper, SL Williams, DE AF Teeguarden, Justin G. Tan, Yu-Mei Edwards, Stephen W. Leonard, Jeremy A. Anderson, Kim A. Corley, Richard A. Kile, Molly L. Simonich, Staci L. Massey Stone, David Tanguay, Robert L. Waters, Katrina M. Harper, Stacey. L. Williams, David E. TI Expanding on Successful Concepts, Models, and Organization SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Letter C1 [Teeguarden, Justin G.; Corley, Richard A.; Waters, Katrina M.] Pacific Northwest Natl Lab, Hlth Effects & Exposure Sci, Richland, WA 99352 USA. [Teeguarden, Justin G.; Anderson, Kim A.; Corley, Richard A.; Simonich, Staci L. Massey; Stone, David; Tanguay, Robert L.; Waters, Katrina M.; Harper, Stacey. L.; Williams, David E.] Oregon State Univ, Dept Environm & Mol Toxicol, Corvallis, OR 93771 USA. [Kile, Molly L.] Oregon State Univ, Sch Biol & Populat Hlth Sci, Corvallis, OR 93771 USA. [Tan, Yu-Mei] US EPA, Natl Exposure Res Lab, Durham, NC 27709 USA. [Edwards, Stephen W.] US EPA, Natl Hlth & Environm Effects Res Lab, Durham, NC 27709 USA. [Leonard, Jeremy A.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37831 USA. [Harper, Stacey. L.] Oregon State Univ, Sch Chem Biol & Environm Engn, Corvallis, OR 97331 USA. RP Teeguarden, JG (reprint author), Pacific Northwest Natl Lab, Hlth Effects & Exposure Sci, Richland, WA 99352 USA.; Teeguarden, JG (reprint author), Oregon State Univ, Dept Environm & Mol Toxicol, Corvallis, OR 93771 USA. EM jt@pnnl.gov NR 4 TC 0 Z9 0 U1 6 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD SEP 6 PY 2016 VL 50 IS 17 BP 8921 EP 8922 DI 10.1021/acs.est.6b03027 PG 2 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA DV3FG UT WOS:000382805800002 PM 27509267 ER PT J AU Cashman, SA Meyer, DE Edelen, AN Ingwersen, WW Abraham, JP Barrett, WM Gonzalez, MA Randall, PM Ruiz-Mercado, G Smith, RL AF Cashman, Sarah A. Meyer, David E. Edelen, Ashley N. Ingwersen, Wesley W. Abraham, John P. Barrett, William M. Gonzalez, Michael A. Randall, Paul M. Ruiz-Mercado, Gerardo Smith, Raymond L. TI Mining Available Data from the United States Environmental Protection Agency to Support Rapid Life Cycle Inventory Modeling of Chemical Manufacturing SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article AB Demands for quick and accurate life cycle assessments create a need for methods to rapidly generate reliable life cycle inventories (LCI). Data mining is a suitable tool for this purpose, especially given the large amount of available governmental data. These data are typically applied to LCIs on a case by-case basis. As linked open data becomes more prevalent, it may be possible to automate LCI using data mining by establishing a reproducible approach for identifying, extracting, and processing the data. This work proposes a method for standardizing and eventually automating the discovery and use of publicly available data at the United States Environmental Protection Agency for chemical-manufacturing LCI. The method is developed using a case study of acetic acid. The data quality and gap analyses for the generated inventory found that the selected data sources can provide information with equal or better reliability and representativeness on air, water, hazardous waste, on-site energy usage, and production volumes but with key data gaps including material inputs, water usage, purchased electricity, and transportation requirements. A comparison of the generated LCI with existing data revealed that the data mining inventory is in reasonable agreement with existing data and may provide a more comprehensive inventory of air emissions and water discharges. The case study highlighted challenges for current data management practices that must be overcome to successfully automate the method using semantic technology. Benefits of the method are that the openly available data can be compiled in a standardized and transparent approach that supports potential automation with flexibility to incorporate new data sources as needed. C1 [Cashman, Sarah A.] Eastern Res Grp, 110 Hartwell Ave, Lexington, MA 02421 USA. [Meyer, David E.; Ingwersen, Wesley W.; Abraham, John P.; Barrett, William M.; Gonzalez, Michael A.; Randall, Paul M.; Ruiz-Mercado, Gerardo; Smith, Raymond L.] US EPA, Natl Risk Management Res Lab, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA. [Edelen, Ashley N.] US EPA, Off Res & Dev, ORISE, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA. RP Meyer, DE (reprint author), US EPA, Natl Risk Management Res Lab, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA. EM Meyer.David@epa.gov NR 29 TC 1 Z9 1 U1 10 U2 10 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD SEP 6 PY 2016 VL 50 IS 17 BP 9013 EP 9025 DI 10.1021/acs.est.6b02160 PG 13 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA DV3FG UT WOS:000382805800012 PM 27517866 ER PT J AU Clar, JG Li, X Impellitteri, CA Bennett-Stamper, C Luxton, TP AF Clar, Justin G. Li, Xuan Impellitteri, Christopher A. Bennett-Stamper, Christina Luxton, Todd P. TI Copper Nanoparticle Induced Cytotoxicity to Nitrifying Bacteria in Wastewater Treatment: A Mechanistic Copper Speciation Study by X-ray Absorption Spectroscopy SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID COATED SILVER NANOPARTICLES; NITRIFICATION INHIBITION; NITROSOMONAS-EUROPAEA; SACCHAROMYCES-CEREVISIAE; AMMONIA MONOOXYGENASE; MUNICIPAL WASTEWATERS; CUO NANOPARTICLES; TOXICITY; OXIDATION; SLUDGE AB With the inclusion of engineered nanomaterials in industrial processes and consumer products, wastewater treatment plants (WWTPs) could serve as a major sink for these emerging contaminants. Previous research has demonstrated that nanomaterials are potentially toxic to microbial communities utilized in biological wastewater treatment (BWT). Copper-based nanoparticles (CuNPs) are of particular interest based on their increasing use in wood treatment, paints, household products, coatings, and byproducts of semiconductor manufacturing. A critical step in BWT is nutrient removal through nitrification. This study examined the potential toxicity of uncoated and polyvinylpyrrolidone (PVP)-coated CuO, and Cu2O nanoparticles, as well as Cu ions to microbial communities responsible for nitrification in BWT. Inhibition was inferred from changes to the specific oxygen uptake rate (sOUR) in the absence and presence of Cu ions and CuNPs. X-ray absorption fine structure spectroscopy, with linear combination fitting (LCF), was utilized to track changes to Cu speciation throughout exposure. Results indicate that the dissolution of Cu ions from CuNPs drive microbial inhibition. The presence of a PVP coating on CuNPs has little effect on inhibition. LCF analysis of the biomass combined with metal partitioning analysis supports the current hypothesis that Cu-induced cytotoxicity is primarily caused by reactive oxygen species formed from ionic Cu in solution via catalytic reaction intermediated by reduced Cu(I) species. C1 [Clar, Justin G.; Li, Xuan; Impellitteri, Christopher A.; Bennett-Stamper, Christina; Luxton, Todd P.] US EPA, Natl Risk Management Res Lab, Off Res & Dev, 5995 Ctr Hill Ave, Cincinnati, OH 45224 USA. [Clar, Justin G.; Li, Xuan] ORISE, Oak Ridge, TN 37831 USA. RP Luxton, TP (reprint author), US EPA, Natl Risk Management Res Lab, Off Res & Dev, 5995 Ctr Hill Ave, Cincinnati, OH 45224 USA. EM Luxton.Todd@epa.gov RI BM, MRCAT/G-7576-2011 FU DOC Office of Science [DE-AC0206CH1357]; U.S. Department of Energy, Basic Energy Sciences; Canadian Light Source; University of Washington; Department of Energy; MRCAT member institutions; Research Participation Program at the Office of Research and Development (ORD), EPA; DOE; EPA FX Any opinions expressed in this paper are those of the authors(s) and do not, necessarily, reflect the official positions and policies of the U.S. EPA. Any mention of products of trade name does not constitute recommendation for use by the U.S. EPA. Thanks to Deborah Roose, Samantha Smith, William Wright, Maria Maurer, Nicholas Sylvest, and Vikram Kapoor for their laboratory expertise. Thanks to Kit Daniels for his engineering support on building the reactor. Use of the Advanced Photon Source (APS), a U.S Department of Energy (DOE) Office of Science User Facility operated for the DOC Office of Science by Argonne National Laboratory under contract No. DE-AC0206CH1357. PNC/XSD facilities (Sector 20) at APS are supported by the U.S. Department of Energy, Basic Energy Sciences, the Canadian Light Source and its funding partners, the University of Washington. MRCAT operations (Sector 10) are supported by the Department of Energy and the MRCAT member institutions. The authors extend their deepest appreciation to the staff of PNC/XSD, Dr. Chenguin Sun and Dr. Zou Finfrock. This project was supported in part by an appointment in the Research Participation Program at the Office of Research and Development (ORD), EPA administered by the Oak Ridge Institute for Science and Education through and interagency agreement between the DOE and EPA. NR 59 TC 0 Z9 0 U1 19 U2 19 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD SEP 6 PY 2016 VL 50 IS 17 BP 9105 EP 9113 DI 10.1021/acs.est.6b01910 PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA DV3FG UT WOS:000382805800022 PM 27466862 ER PT J AU Chang, XJ Bouchard, DC AF Chang, Xiaojun Bouchard, Dermont C. TI Surfactant-Wrapped Multiwalled Carbon Nanotubes in Aquatic Systems: Surfactant Displacement in the Presence of Humic Acid SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID GOLD NANOPARTICLES; SOLUTION CHEMISTRY; POROUS-MEDIA; ADSORPTION; DEPOSITION; DISPERSION; SORPTION; NANOMATERIALS; CONFORMATION; CYTOTOXICITY AB Sodium dodecyl sulfate (SDS) facilitates multiwalled carbon nanotube (MWCNT) debundling and enhances nanotube stability in the aqueous environment by adsorbing on the nanotube surfaces, thereby increasing repulsive electrostatic forces and steric effects. The resulting SDS-wrapped MWCNTs are utilized in industrial applications and have been widely employed in environmental studies. In the present study, MWCNTs adsorbed SDS during ultrasonication to form stable MWCNTs suspensions. Desorption of SDS from MWCNTs surfaces was then investigated as a function of Suwannee River Humic Acid (SRHA) and background electrolyte concentrations. Due to hydrophobic effects and pi-pi interactions, MWCNTs exhibit higher affinity for SRHA than SDS. In the presence of SRHA, SDS adsorbed on MWCNTs was displaced. Cations (Na+, Ca2+) decreased SDS desorption from MWCNTs due to charge screening effects. Interestingly, the presence of the divalent calcium cation facilitated multilayered SRHA adsorption on MWCNTs through bridging effects, while monovalent sodium reduced SRHA adsorption. Results of the present study suggest that properties of MWCNTs wrapped with commercial surfactants will be altered when these materials are released to surface waters and the surfactant coating will be displaced by natural organic matter (NOM). Changes on their surfaces will significantly affect MWCNTs fate in aquatic environments. C1 [Chang, Xiaojun] Natl Res Council Res, 960 Coll Stn Rd, Athens, GA 30605 USA. [Bouchard, Dermont C.] US EPA, Off Res & Dev, Natl Exposure Res Lab, 960 Coll Stn Rd, Athens, GA 30605 USA. RP Bouchard, DC (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, 960 Coll Stn Rd, Athens, GA 30605 USA. EM Bouchard.Dermont@epa.gov NR 55 TC 0 Z9 0 U1 16 U2 16 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD SEP 6 PY 2016 VL 50 IS 17 BP 9214 EP 9222 DI 10.1021/acs.est.6b01536 PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA DV3FG UT WOS:000382805800034 PM 27500910 ER PT J AU De la Cruz, FB Green, RB Hater, GR Chanton, JP Thoma, ED Harvey, TA Barlaz, MA AF De la Cruz, Florentino B. Green, Roger B. Hater, Gary R. Chanton, Jeffrey P. Thoma, Eben D. Harvey, Tierney A. Barlaz, Morton A. TI Comparison of Field Measurements to Methane Emissions Models at a New Landfill SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID UNITED-STATES; OXIDATION; SOILS AB Estimates of methane emissions from landfills rely primarily on models due to both technical and economic limitations. While models are easy to implement, there is uncertainty due to the use of parameters that are difficult to validate. The objective of this research was to compare modeled emissions using several greenhouse gas (GHG) emissions reporting protocols including: (1) Intergovernmental Panel on Climate Change (IPCC); (2) U.S. Environmental Protection Agency Greenhouse Gas Reporting Program (EPA GHGRP); (3) California Air Resources Board (CARB); and (4) Solid Waste Industry for Climate Solutions (SWICS), with measured emissions data collected over three calendar years from a young landfill with no gas collection system. By working with whole landfill measurements of fugitive methane emissions and methane oxidation, the collection efficiency could be set to zero, thus eliminating one source of parameter uncertainty. The models consistently overestimated annual methane emissions by a factor ranging from 4-31. Varying input parameters over reasonable ranges reduced this range to 1.3-8. Waste age at the studied landfill was less than four years and the results suggest the need for measurements at additional landfills to evaluate the accuracy of the tested models to young landfills. C1 [De la Cruz, Florentino B.; Barlaz, Morton A.] North Carolina State Univ, Dept Civil Construct & Environm Engn, Campus Box 7908, Raleigh, NC 27695 USA. [Green, Roger B.; Hater, Gary R.] Waste Management Inc, 2956 Montana Ave, Cincinnati, OH 45211 USA. [Chanton, Jeffrey P.] Florida State Univ, Dept Earth Ocean & Atmospher Sci, Tallahassee, FL 32306 USA. [Thoma, Eben D.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. [Harvey, Tierney A.] Univ Cent Oklahoma, Dept Engn & Phys, Edmond, OK 73034 USA. RP De la Cruz, FB (reprint author), North Carolina State Univ, Dept Civil Construct & Environm Engn, Campus Box 7908, Raleigh, NC 27695 USA. EM fbdelacr@ncsu.edu FU Waste Management, Inc. FX Partial funding for this research was provided by Waste Management, Inc. We thank Dr. Jason Osborne of the Department of Statistics, NCSU for the assistance on statistical data analyses. The views expressed in this paper are those of the author(s) and do not necessarily represent the views or policies of the U.S. Environmental Protection Agency. NR 32 TC 0 Z9 0 U1 7 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD SEP 6 PY 2016 VL 50 IS 17 BP 9432 EP 9441 DI 10.1021/acs.est.6b00415 PG 10 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA DV3FG UT WOS:000382805800058 PM 27455372 ER PT J AU Fan, DM Johnson, GO Tratnyek, PG Johnson, RL AF Fan, Dimin Johnson, Graham O'Brien Tratnyek, Paul G. Johnson, Richard L. TI Sulfidation of Nano Zerovalent Iron (nZVI) for Improved Selectivity During In-Situ Chemical Reduction (ISCR) SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID ZERO-VALENT IRON; POROUS-MEDIA; GROUNDWATER REMEDIATION; ENVIRONMENTAL APPLICATIONS; FE/FES NANOPARTICLES; HYDROGEN-SULFIDE; REACTIVITY; FIELD; PARTICLES; TRICHLOROETHYLENE AB The high reactivity of nano zerovalent iron (nZVI) leads to inefficient treatment due to competition with various natural reductant demand (NRD) processes, especially the reduction of water to hydrogen. Here we show that this limitation can be alleviated by sulfidation (i.e., modification by reducing sulfur compounds). nZVI synthesized on carboxylmethylcelluose (CMC-nZVI) was sulfidated with either sulfide or dithionite. The reactivity of the resulting materials was examined with three complementary assays: (i) direct measurement of hydrogen production, (ii) reduction of a colorimetric redox probe (indigo disulfonate, I2S), and (iii) dechlorination of trichloroethylene (TCE). The results indicate that sulfidation at S/Fe molar ratios of >0.3, effectively eliminates reaction with water, but retains significant reactivity with TCE. However, sulfidation with sulfide leaves most of the nZVI as Fe(0), whereas dithionite converts a majority of the nZVI to FeS (thus consuming much of the reducing capacity originally provided by the Fe(0)). Simplified numerical models show that the reduction kinetics of 12S and TCE are mainly dependent on the initial reducing equivalents and that the TCE reduction rate is affected by the aging of FeS. Overall, the results suggest that pretreatment of nZVI with reducing sulfur compounds could result in substantial improvement in nZVI selectivity. C1 [Fan, Dimin; Johnson, Graham O'Brien; Tratnyek, Paul G.; Johnson, Richard L.] Oregon Hlth & Sci Univ, Inst Environm Hlth, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA. [Johnson, Richard L.] Oregon Hlth & Sci Univ, OHSU PSU Sch Publ Hlth, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA. [Fan, Dimin] US EPA, Off Superfund Remediat & Technol Innovat, Arlington, VA 22202 USA. RP Johnson, RL (reprint author), Oregon Hlth & Sci Univ, Inst Environm Hlth, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA.; Johnson, RL (reprint author), Oregon Hlth & Sci Univ, OHSU PSU Sch Publ Hlth, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA. EM rick.johnson.phd@gmail.com RI fan, dimin/D-3200-2017 FU Strategic Environmental Research and Development Program of the U.S. Department of Defense [ER-2308] FX This material is based on work supported by the Strategic Environmental Research and Development Program of the U.S. Department of Defense, Award Number ER-2308. This report has not been subject to review by SERDP and therefore does not necessarily reflect agency views and no official endorsements should be inferred. We thank J.Z. Bandstra for his input on formulation of the kinetic model for aging. NR 65 TC 2 Z9 2 U1 16 U2 16 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD SEP 6 PY 2016 VL 50 IS 17 BP 9558 EP 9565 DI 10.1021/acs.est.6b02170 PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA DV3FG UT WOS:000382805800072 PM 27454131 ER PT J AU Lee, SS Paspalof, AM Snow, DD Richmond, EK Rosi-Marshall, EJ Kelly, JJ AF Lee, Sylvia S. Paspalof, Alexis M. Snow, Daniel D. Richmond, Erinn K. Rosi-Marshall, Emma J. Kelly, John J. TI Occurrence and Potential Biological Effects of Amphetamine on Stream Communities SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID PERSONAL CARE PRODUCTS; WASTE-WATER CONTAMINANTS; ILLICIT DRUGS; SEWAGE WATER; FRESH-WATER; BACTERIAL COMMUNITIES; SECONDARY PRODUCTION; PHARMACEUTICALS; ENVIRONMENT; METABOLITES AB The presence of pharmaceuticals, including illicit drugs in aquatic systems, is a topic of environmental significance because of their global occurrence and potential effects on aquatic ecosystems and human health, but few studies have examined the ecological effects of illicit drugs. We conducted a survey of several drug residues, including the potentially illicit drug amphetamine, at 6 stream sites along an urban to rural gradient in Baltimore, Maryland, U.S.A. We detected numerous drugs, including amphetamine (3 to 630 ng L-1), in all stream sites. We examined the fate and ecological effects of amphetamine on biofilm, seston, and aquatic insect communities in artificial streams exposed to an environmentally relevant concentration (1 mu g L-1) of amphetamine. The amphetamine parent compound decreased in the artificial streams from less than 1 mu g L-1 on day 1 to 0.11 mu g L-1 on day 22. In artificial streams treated with amphetamine, there was up to 45% lower biofilm chlorophyll a per ash-free dry mass, 85% lower biofilm gross primary production, 24% greater seston ash-free dry mass, and 30% lower seston community respiration compared to control streams. Exposing streams to amphetamine also changed the composition of bacterial and diatom communities in biofilms at day 21 and increased cumulative dipteran emergence by 65% and 89% during the first and third weeks of the experiment, respectively. This study demonstrates that amphetamine and other biologically active drugs are present in urban streams and have the potential to affect both structure and function of stream communities. C1 [Lee, Sylvia S.; Rosi-Marshall, Emma J.] Cary Inst Ecosyst Studies, Millbrook, NY 12545 USA. [Paspalof, Alexis M.; Snow, Daniel D.] Univ Nebraska, Water Sci Lab, Lincoln, NE 68583 USA. [Richmond, Erinn K.] Monash Univ, Water Studies Ctr, Melbourne, Vic 3800, Australia. [Kelly, John J.] Loyola Univ, Dept Biol, Chicago, IL 60660 USA. [Lee, Sylvia S.] US EPA, Off Res & Dev, Arlington, VA 22202 USA. RP Lee, SS (reprint author), Cary Inst Ecosyst Studies, Millbrook, NY 12545 USA.; Lee, SS (reprint author), US EPA, Off Res & Dev, Arlington, VA 22202 USA. EM lees@caryinstitute.org FU Wallace Genetic Foundation; Baltimore Ecosystem Study Long Term Ecological Research program (National Science Foundation) [DEB 1027188]; Millbrook Garden Club; Hudson River Foundation; Brycon Incorporated FX We thank Hayley Lemoine for assistance with the stream experiment and collection of emergence data. S.L. thanks David A. Gandy for assistance with Primer, Miguel Rojas for assistance with mothur, Michael Schmeltz for assistance with SAS, John Meyer for permission to use the chironomid image in the abstract graphic, and three anonymous reviewers for providing comments on the original manuscript. Funding for this research was provided in part by awards to E.R.-M. from the Wallace Genetic Foundation and the Baltimore Ecosystem Study Long Term Ecological Research program (National Science Foundation grant number DEB 1027188) and awards to A.P. from the Millbrook Garden Club, Hudson River Foundation (Tibor T. Pogar Fellowship), and Brycon Incorporated. NR 72 TC 0 Z9 0 U1 5 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD SEP 6 PY 2016 VL 50 IS 17 BP 9727 EP 9735 DI 10.1021/acs.est.6b03717 PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA DV3FG UT WOS:000382805800091 PM 27513635 ER PT J AU Wang, P Wang, H Linker, L Tian, R AF Wang, Ping Wang, Harry Linker, Lewis Tian, Richard TI Effects of cross-channel bathymetry and wind direction on destratification and hypoxia reduction in the Chesapeake Bay SO ESTUARINE COASTAL AND SHELF SCIENCE LA English DT Article DE USA Chesapeake Bay; Wind; Destratification; Bathymetry effect; Anoxia; Hypoxia ID STRATIFIED ESTUARY; DISSOLVED-OXYGEN; CIRCULATION; TRANSPORT AB A coupled estuarine hydrodynamic model and water quality model were used to analyze differences in destratification and anoxia/hypoxia reduction by wind directions in the north-south oriented Chesapeake estuary, USA. The predominant cross-channel bathymetry in the Bay's anoxic center is asymmetric with a steeper and narrower shoal on the eastern shore than on the western shore, which modifies wind-induced circulation differently for two opposite wind directions. Model experiments of winds for 2-day at 8 m/s indicated that, for a stratified water over the aforementioned asymmetric bottom topography, the easterly wind caused greater destratification and hypoxia reduction than the westerly wind. This is a result of differential modulations on the two wind-induced cross-channel circulations by the asymmetric cross channel bathymetry. The downwelling along the gentle slope in the easterly wind was characterized with stronger baroclinicity than the downwelling along the steep slope (nearly perpendicular to surfaces of constant density) in the westerly wind. On the broad slope, there undergo greater contrasting density readjustments to the vorticity changes around the bottom boundary layer (BBL) during upslope and downslope motions. During the upslope condition, the flow in BBL tends to decelerate under adverse pressure gradient which leads to a stable condition in the outer layer; whereas, during the downslope condition, the BBL tends to accelerate under favourable pressure gradient, which leads to unstable condition in the outer layer of the large scale flow. Overall, the easterly wind caused greater anoxia reduction than the westerly wind during the entire wind period. A similar case was found for northerly versus southerly winds in the early stages of the wind period; modulated by the aforementioned bathymetry on the wind-induced cross-channel circulation, the northerly wind caused greater anoxia reduction than the southerly wind. However, as wind continues, the wind-induced along-channel circulation influences a larger area of greater hypoxia in the mid-Bay, by which the southerly wind causes a greater destratification and anoxia reduction than the northerly wind. This can supersede the greater destratification and anoxia reduction by the northerly wind under the bathymetry-affected cross-channel circulation. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Wang, Ping; Wang, Harry] Virginia Inst Marine Sci, POB 1346, Gloucester, VA 23062 USA. [Linker, Lewis] US EPA, Chesapeake Bay Program Off, 410 Severn Ave, Annapolis, MD 21403 USA. [Tian, Richard] Univ Maryland, Ctr Environm Sci, Chesapeake Bay Program Off, 410 Severn Ave, Annapolis, MD 21403 USA. RP Wang, P (reprint author), VIMS Chesapeake Bay Off, 410 Severn Ave, Annapolis, MD 21403 USA. EM pwang@chesapeakebay.net FU USEPA Grant [CB963060-01] FX The writers appreciate the thoughtful comments and professional inputs from two anonymous reviewers, and the support from Richard Batiuk, the Associate Director for Science at the EPA Chesapeake Bay Program Office. This project is supported by USEPA Grant CB963060-01. NR 60 TC 0 Z9 0 U1 3 U2 3 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0272-7714 EI 1096-0015 J9 ESTUAR COAST SHELF S JI Estuar. Coast. Shelf Sci. PD SEP 5 PY 2016 VL 178 BP 168 EP 188 DI 10.1016/j.ecss.2016.05.009 PG 21 WC Marine & Freshwater Biology; Oceanography SC Marine & Freshwater Biology; Oceanography GA DT0HQ UT WOS:000381164900018 ER PT J AU da Silva-Rackov, CKO Lawal, WA Nfodzo, PA Vianna, MMGR do Nascimento, CAO Choi, H AF da Silva-Rackov, Celyna K. O. Lawal, Wasiu A. Nfodzo, Prince A. Vianna, Marilda M. G. R. do Nascimento, Claudio A. O. Choi, Hyeok TI Degradation of PFOA by hydrogen peroxide and persulfate activated by iron-modified diatomite SO APPLIED CATALYSIS B-ENVIRONMENTAL LA English DT Article DE Perfluorooctanoic acid; Superoxide radical anions; Persulfate; Hydrogen peroxide; Diatomite ID PERFLUOROOCTANOIC ACID; HETEROGENEOUS CATALYSTS; WATER; OXIDATION; DECOMPOSITION; CHEMISTRY; OXIDANT; CARBON; SOIL AB Perfluorooctanoic acid (PFOA) is one of the most problematic perfluoroalkyl compounds widely used to make fluoropolymers. The exceptional strength of the carbon-fluorine (C-F) bond in PFOA makes it extremely resistant to oxidative attack even by hydroxyl radicals, resulting in its persistence in the environment. As a result, this study investigated generation of superoxide radical anions to reductively decompose such a highly oxidized chemical, PFOA. Catalyzed hydrogen peroxide (CHP) propagations and activated persulfate systems for generating reductive species such as superoxide radical anions along with oxidizing hydroxyl and sulfate radicals were examined. Improved activation mechanism for hydrogen peroxide and persulfate by using iron-modified diatomite (MD), which favorably leads the reaction to generation of the reductive radicals, was proposed. Three comparative systems were efficient in order of CHP > hydrogen peroxide-activated persulfate > alkaline-activated persulfate at PFOA decomposition of 83%, 69% and 48%, respectively, under given conditions. The heterogeneous system employing MD was also compared with a homogeneous system employing dissolved Fe ions to evaluate the effectiveness of MD. All the results supported that MD has significant catalytic activity for the degradation of PFOA when used to activate hydrogen peroxide and persulfate for the generation of superoxide radical anions. The reductive systems coupled with MD exhibited high decompose efficiency for the most recalcitrant chemical, PFOA and thus high potential for the decomposition of other problematic halogenated compounds. (C) 2016 Elsevier B.V. All rights reserved. C1 [da Silva-Rackov, Celyna K. O.; Vianna, Marilda M. G. R.; do Nascimento, Claudio A. O.] Univ Sao Paulo, Dept Chem Engn, 580 Lineu Prestes Ave, BR-05508000 Sao Paulo, SP, Brazil. [da Silva-Rackov, Celyna K. O.; Choi, Hyeok] Univ Texas Arlington, Dept Civil Engn, 416 Yates St, Arlington, TX 76019 USA. [Lawal, Wasiu A.; Choi, Hyeok] Univ Texas Arlington, Environm & Earth Sci Program, 500 Yates St, Arlington, TX 76019 USA. [Nfodzo, Prince A.] US EPA, Compliance Assurance & Enforcement Div, Reg 6,1445 Ross Ave, Dallas, TX 75202 USA. RP Choi, H (reprint author), Univ Texas Arlington, Dept Civil Engn, 416 Yates St, Arlington, TX 76019 USA.; Choi, H (reprint author), Univ Texas Arlington, Environm & Earth Sci Program, 500 Yates St, Arlington, TX 76019 USA. EM hchoi@uta.edu FU University of Texas at Arlington; Brazilian Program of Sciences Without Borders; CAPES [1944-13-4] FX This research was supported partly by the faculty startup funds of The University of Texas at Arlington, the Brazilian Program of Sciences Without Borders, and Agency CAPES (Process # 1944-13-4). This paper has not been subjected to internal policy review of the U.S. EPA. Therefore, the research results do not necessarily reflect the views of the agency. NR 43 TC 2 Z9 2 U1 48 U2 144 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0926-3373 EI 1873-3883 J9 APPL CATAL B-ENVIRON JI Appl. Catal. B-Environ. PD SEP 5 PY 2016 VL 192 BP 253 EP 259 DI 10.1016/j.apcatb.2016.03.067 PG 7 WC Chemistry, Physical; Engineering, Environmental; Engineering, Chemical SC Chemistry; Engineering GA DL8JE UT WOS:000375887500028 ER PT J AU Hang, J Lin, M Wong, DC Wang, XM Wang, BM Buccolieri, R AF Hang, Jian Lin, Man Wong, David C. Wang, Xuemei Wang, Baomin Buccolieri, Riccardo TI On the influence of viaduct and ground heating on pollutant dispersion in 2D street canyons and toward single-sided ventilated buildings SO ATMOSPHERIC POLLUTION RESEARCH LA English DT Article DE Computational Fluid Dynamics ( CFD); Two-dimensional (2D) street canyon; Ground heating; Viaduct and road barriers; Particle number PN) ID WIND-TUNNEL MEASUREMENTS; CFD SIMULATION; URBAN AREAS; NUMERICAL-SIMULATION; PARTICLE CONCENTRATION; AIRBORNE TRANSMISSION; NATURAL VENTILATION; ISOLATION ROOM; BUOYANT FLOWS; AIR-QUALITY AB This paper employs Computational Fluid Dynamic (CFD) simulations to investigate the influence of ground heating intensities and viaduct configurations on gaseous and particle dispersion within twodimensional idealized street canyons (typical aspect ratio H/W = 1) and their transport from outdoor to leeward and windward rooms of naturally-ventilated buildings. Without viaduct, the ground heating exists at the street ground above which the pollutant source is located, while in the presence of viaduct the ground heating only occurs at the viaduct ground surface and pollutant source is slightly above the viaduct. Results show that viaduct significantly reduces overall spatial mean indoor concentrations of gaseous pollutant (< K >) and indoor particle number (PN) in all rooms being the elevated pollutant source above the viaduct compared to those without the viaduct. Road barriers on the viaduct slow down the flow above it and slightly increase indoor < K >, but they reduce indoor PN due to the enhanced particle deposition onto viaduct surfaces. The uniform heating of street ground or viaduct ground surface strengthens recirculation flows in street canyon, reducing < K > and PN of fine particle (diameter d = 1 mm), but for larger particles indoor PN distribution is complicated by the interaction of gravity, buoyancy and wind-induced recirculation. Although further investigations are still required to propose a practical framework on viaduct design, this paper is one of the first attempts to study the effect of viaduct on street pollutant dispersion. C1 [Hang, Jian; Lin, Man; Wang, Xuemei; Wang, Baomin] Sun Yat Sen Univ, Sch Atmospher Sci, Guangzhou, Guangdong, Peoples R China. [Hang, Jian] Sun Yat Sen Univ, Inst Earth Climate & Environm Syst, Guangzhou, Guangdong, Peoples R China. [Wong, David C.] US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Buccolieri, Riccardo] Univ Salento, Dipartimento Sci & Tecnol Biol & Ambientali, SP 6 Lecce Monteroni, I-73100 Lecce, Italy. RP Buccolieri, R (reprint author), Univ Salento, Dipartimento Sci & Tecnol Biol & Ambientali, SP 6 Lecce Monteroni, I-73100 Lecce, Italy. EM riccardo.buccolieri@unisalento.it FU National Natural Science Foundation of China [51478486]; National Science Fund for Distinguished Young Scholars [41425020]; Fundamental Research Funds for the Central Universities [161gzd01]; Guangdong Provincial higher education funds for high level talents [38000-52010002] FX This study was financially supported by the National Natural Science Foundation of China (No 51478486) and the National Science Fund for Distinguished Young Scholars (No 41425020) as well as the Fundamental Research Funds for the Central Universities (No 161gzd01) and Guangdong Provincial higher education funds for high level talents (38000-52010002). The three anonymous reviewers who propose helpful comments and suggestions are also gratefully acknowledged. NR 59 TC 0 Z9 0 U1 0 U2 0 PU TURKISH NATL COMMITTEE AIR POLLUTION RES & CONTROL-TUNCAP PI BUCA PA DOKUZ EYLUL UNIV, DEPT ENVIRONMENTAL ENGINEERING, TINAZTEPE CAMPUS, BUCA, IZMIR 35160, TURKEY SN 1309-1042 J9 ATMOS POLLUT RES JI Atmos. Pollut. Res. PD SEP PY 2016 VL 7 IS 5 BP 817 EP 832 DI 10.1016/j.apr.2016.04.009 PG 16 WC Environmental Sciences SC Environmental Sciences & Ecology GA EN9ZD UT WOS:000396357200009 ER PT J AU Zimmerman, BD Korajkic, A Brinkman, NE Grimm, AC Ashbolt, NJ Garland, JL AF Zimmerman, Brian D. Korajkic, Asja Brinkman, Nichole E. Grimm, Ann C. Ashbolt, Nicholas J. Garland, Jay L. TI A Spike Cocktail Approach to Improve Microbial Performance Monitoring for Water Reuse SO WATER ENVIRONMENT RESEARCH LA English DT Article ID ESCHERICHIA-COLI O157-H7; MUNICIPAL WASTE-WATER; MEMBRANE BIOREACTOR TECHNOLOGY; HOLLOW-FIBER ULTRAFILTRATION; BACILLUS-SUBTILIS SPORES; ENTERIC VIRUSES; INDICATOR MICROORGANISMS; CLOSTRIDIUM-PERFRINGENS; CRYPTOSPORIDIUM OOCYSTS; TREATMENT PLANTS AB Water reuse, via either centralized treatment of traditional wastewater or decentralized treatment and on-site reuse, is becoming an increasingly important element of sustainable water management. Despite advances in waterborne pathogen detection methods, low and highly variable pathogen levels limit their utility for routine evaluation of health risks in water reuse systems. Therefore, there is a need to improve our understanding of the linkage between pathogens and more readily measured process indicators during treatment. This paper describes an approach for constructing spiking experiments to relate the behavior of viral, bacterial, and protozoan pathogens with relevant process indicators. General issues are reviewed, and the spiking protocol is applied as a case study example to improve microbial performance monitoring and health risk evaluation in a water reuse system. This approach provides a foundation for the development of novel approaches to improve real or near-real time performance monitoring of water recycling systems. C1 [Zimmerman, Brian D.; Korajkic, Asja; Brinkman, Nichole E.; Grimm, Ann C.; Ashbolt, Nicholas J.; Garland, Jay L.] US EPA, Off Res & Dev, Natl Exposure Res Lab, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA. [Ashbolt, Nicholas J.] Univ Alberta, Sch Publ Hlth, 3-57D South Acad Bldg, Edmonton, AB T6G 2G7, Canada. RP Garland, JL (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA. EM garland.jay@epa.gov FU United States Environmental Protection Agency through its Office of Research and Development FX The United States Environmental Protection Agency through its Office of Research and Development funded and managed the research described herein. It has been subjected to the Agency's administrative review and approved for publication. The contribution of Brian Zimmerman was administered through a student services contract. The views expressed in this article are those of the author(s) and do not necessarily represent the views or policies of the U.S. Environmental Protection Agency. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 154 TC 1 Z9 1 U1 2 U2 2 PU WATER ENVIRONMENT FEDERATION PI ALEXANDRIA PA 601 WYTHE ST, ALEXANDRIA, VA 22314-1994 USA SN 1061-4303 EI 1554-7531 J9 WATER ENVIRON RES JI Water Environ. Res. PD SEP 1 PY 2016 VL 88 IS 9 BP 824 EP 837 DI 10.2175/106143016X14609975747522 PG 14 WC Engineering, Environmental; Environmental Sciences; Limnology; Water Resources SC Engineering; Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA EJ6EJ UT WOS:000393311300004 PM 27654081 ER PT J AU Oudejans, L O'Kelly, J Evans, AS Wyrzykowska-Ceradini, B Touati, A Tabor, D Snyder, EG AF Oudejans, Lukas O'Kelly, Jeremy Evans, Anthony S. Wyrzykowska-Ceradini, Barbara Touati, Abderrahmane Tabor, Dennis Snyder, Emily Gibb TI Decontamination of personal protective equipment and related materials contaminated with toxic industrial chemicals and chemical warfare agent surrogates SO JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING LA English DT Article DE PPE; Decontamination line; Doffing; Toxic industrial chemical; Chemical warfare agent ID SIMULANTS; EFFICACY; LIQUID AB The goal of this study was to provide quantitative efficacy information relevant to technical and forensic decontamination that may assist safety officers in mitigating health hazards to personnel and minimizing the potential transfer of chemicals by cross-contamination from a chemical incident scene. To achieve this goal, decontamination solutions were evaluated using representative contact times of personal protective equipment (PPE) and related materials with the chemical contaminant at operationally relevant decontamination dwell times. The study included four toxic industrial chemicals (TICs) and two chemical warfare agent (CWA) surrogates, eight decontamination solutions and seven PPE-related materials that would transition through a personnel decontamination line. Measured neutralization efficacies following a 2.0-min dwell time varied strongly by chemical with no/very minimal efficacy observed for decontaminants against materials contaminated with nitrobenzene, chlordane, and phenol. Higher efficacies up to 60% were observed for full strength bleach, RSDL (R) and EasyDECON (R) DF200 products against malathion, carbaryl, and 2-chloroethyl ethyl sulfide. Other decontamination solutions like detergent and water, 10x diluted bleach, and pH-amended bleach were found to be non-efficacious (less than 20%) against any of the chemicals. The short dwell time and limited amount of decontaminant on the contaminated surface limits the expected efficacy. Therefore, the contribution of neutralization to the decontamination process while responders are preparing to doff personal protective equipment may be limited. Published by Elsevier Ltd. C1 [Oudejans, Lukas; Snyder, Emily Gibb] US EPA, Off Res & Dev, Natl Homeland Secur Res Ctr, Res Triangle Pk, NC 27711 USA. [O'Kelly, Jeremy; Evans, Anthony S.] Fed Bur Invest, CBRN Sci Unit, Lab Div, Quantico, VA USA. [Wyrzykowska-Ceradini, Barbara; Touati, Abderrahmane] JACOBS Technol Inc, Durham, NC USA. [Tabor, Dennis] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. RP Oudejans, L (reprint author), US EPA, Mail Drop E343-06,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM oudejans.lukas@epa.gov NR 17 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 2213-3437 J9 J ENVIRON CHEM ENG JI J. Environ. Chem. Eng. PD SEP PY 2016 VL 4 IS 3 BP 2745 EP 2753 DI 10.1016/j.jece.2016.05.022 PG 9 WC Engineering, Environmental SC Engineering GA EH3UV UT WOS:000391698400016 ER PT J AU Moskalik, A Hula, A Barba, D Kargul, J AF Moskalik, Andrew Hula, Aaron Barba, Daniel Kargul, John TI Investigating the Effect of Advanced Automatic Transmissions on Fuel Consumption Using Vehicle Testing and Modeling SO SAE INTERNATIONAL JOURNAL OF ENGINES LA English DT Article AB In preparation for the midterm evaluation (MTE) of the 2022-2025 Light-Duty Greenhouse Gas (LD GHG) emissions standards, the Environmental Protection Agency (EPA) is refining and revalidating their Advanced Light-Duty Powertrain and Hybrid Analysis (ALPHA) tool using newly acquired data from model year 2013-2015 engines and vehicles. ALPHA is a physics-based, forward-looking, full vehicle computer simulation capable of analyzing various vehicle types with different powertrain technologies, showing realistic vehicle behavior, and auditing of all internal energy flows in the model. As part of the validation of ALPHA, the EPA obtained model year 2014 Dodge Chargers equipped with 3.6 liter V6 engines and either a NAG1 five-speed automatic transmission or an 845RE eight-speed automatic transmission. Vehicles were tested on a chassis dynamometer; test results showed eight-speed vehicles averaging 6.5% reduction in unadjusted combined city-highway fuel consumption compared to five-speed vehicles. In addition, an 845RE eight-speed transmission was obtained and tested in a standalone transmission test rig. The measured transmission parameters were used in ALPHA to simulate the behavior and fuel consumption of the eight-speed Dodge Charger. A companion model for the five-speed Charger was also constructed; the resulting simulated fuel consumption for both vehicles closely matched the test results. This paper uses the validated ALPHA model to predict the effectiveness improvement of real-world transmissions over a baseline circa 2008 four-speed transmission, and to predict further improvements possible from future eight-speed transmissions. To that end, transmission models for a four-speed automatic transmission and future eight-speed automatic transmissions were constructed, and ALPHA was used to predict the fuel consumption differences of a Dodge Charger equipped with these transmissions. A fuel consumption reduction of over 12% was predicted when comparing a future eight-speed transmission to a baseline four-speed. Predicted fuel consumption reduction was over 16% when the engines were resized to maintain a constant acceleration performance. C1 [Moskalik, Andrew; Hula, Aaron; Barba, Daniel; Kargul, John] US Environm Protect Agcy, Washington, DC 20004 USA. RP Moskalik, A (reprint author), US Environm Protect Agcy, Washington, DC 20004 USA. EM moskalik.andrew@epa.gov NR 15 TC 0 Z9 0 U1 0 U2 0 PU SAE INT PI WARRENDALE PA 400 COMMONWEALTH DR, WARRENDALE, PA 15096 USA SN 1946-3936 EI 1946-3944 J9 SAE INT J ENGINES JI SAE Int. J. Engines PD SEP PY 2016 VL 9 IS 3 BP 1916 EP 1928 DI 10.4271/2016-01-1142 PG 13 WC Transportation Science & Technology SC Transportation GA EF8RD UT WOS:000390595900050 ER PT J AU Fan, DM O'Carroll, DM Elliott, DW Xiong, Z Tratnyek, PG Johnson, RL Garcia, AN AF Fan, Dimin O'Carroll, Denis M. Elliott, Daniel W. Xiong, Zhong Tratnyek, Paul G. Johnson, Richard L. Garcia, Ariel Nunez TI Selectivity of Nano Zerovalent Iron in In Situ Chemical Reduction: Challenges and Improvements SO REMEDIATION-THE JOURNAL OF ENVIRONMENTAL CLEANUP COSTS TECHNOLOGIES & TECHNIQUES LA English DT Article ID ZERO-VALENT IRON; GROUNDWATER REMEDIATION; ACTIVATED CARBON; SOURCE ZONE; DECHLORINATION; PARTICLES; NZVI; TRICHLOROETHYLENE; NANOPARTICLES; METALS AB Nano zerovalent iron (nZVI) is a promising remediation technology utilizing in situ chemical reduction (ISCR) to clean up contaminated groundwater at hazardous waste sites. The small particle size and large surface area of nZVI result in high reactivity and rapid destruction of contaminants. Over the past 20 years, a great deal of research has advanced the nZVI technology from bench-scale tests to field-scale applications. However, to date, the overall number of well-characterized nZVI field deployments is still small compared to other alternative remedies that are more widely applied. Apart from the relatively high material cost of nZVI and questions regarding possible nanotoxicological side effects, one of the major obstacles to the widespread utilization of nZVI in the field is its short persistence in the environment due to natural reductant demand (NRD). The NRD for nZVI is predominantly due to reduction of water, but other reactions with naturally present oxidants (e.g., oxygen) occur, resulting in situ conditions that are reducing (high in ferrous iron phases and H-2) but with little or no Fe(0). This article reviews the main biogeochemical processes that determine the selectivity and longevity of nZVI, summarizes data from prior (laboratory and field) studies on the longevity of various common types of nZVI, and describes modifications of nZVI that could improve its selectivity and longevity for full-scale applications of ISCR. (C) 2016 Wiley Periodicals, Inc. C1 [Fan, Dimin] US EPA, Off Land & Emergency Management, Washington, DC 20460 USA. [O'Carroll, Denis M.] Univ New South Wales, Sch Civil & Environm Engn, Sydney, NSW, Australia. [O'Carroll, Denis M.] Univ New South Wales, Connect Waters Initiat, Sydney, NSW, Australia. [Elliott, Daniel W.] Geosyntec Consultants Inc, Atlanta, GA USA. [Xiong, Zhong] Haley & Aldrich Inc, Charlestown, MA USA. [Tratnyek, Paul G.] Oregon Hlth & Sci Univ, Div Environm & Biomol Syst, Portland, OR 97201 USA. [Garcia, Ariel Nunez] Western Univ, Dept Civil & Environm Engn, London, ON, Canada. RP Fan, DM (reprint author), US EPA, Off Land & Emergency Management, Washington, DC 20460 USA. NR 42 TC 0 Z9 0 U1 8 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1051-5658 EI 1520-6831 J9 REMEDIATION JI Remediation PD FAL PY 2016 VL 26 IS 4 BP 27 EP 40 DI 10.1002/rem.21481 PG 14 WC Engineering, Environmental SC Engineering GA EE3JE UT WOS:000389482900003 ER PT J AU McDonald, S Gbondo-Tugbawa, S Prabhu, C Mahoney, E Garvey, E Frederick, JJ AF McDonald, Shane Gbondo-Tugbawa, Solomon Prabhu, Chitra Mahoney, Eileen Garvey, Edward Frederick, Jeffrey J. TI Groundwater Impacts on Surface Water and Sediment-Gowanus Canal, Brooklyn, New York SO REMEDIATION-THE JOURNAL OF ENVIRONMENTAL CLEANUP COSTS TECHNOLOGIES & TECHNIQUES LA English DT Article ID CHEMICAL DATABASES; DISCHARGE; SEA AB The Gowanus Canal Superfund Site in Brooklyn, New York, is an approximately 1.5-mile (1.61-km) long estuary that was historically converted into a canal for industrial and commercial purposes. Three manufactured gas plants (MGPs) were formerly located on the Gowanus Canal and discharged waste into it. Surface sediments remain highly contaminated with polycyclic aromatic hydrocarbons (PAHs) long after the MGPs were razed. A hydrogeologic assessment indicates that groundwater passes through the deeper coal tar-contaminated sediment prior to discharging to the canal. This study was undertaken to investigate if groundwater passing through coal tar-contaminated sediment could be responsible for the ongoing contamination of both surface sediments and surface water in the canal. PAH compound distributions in surface water samples collected from the tidal canal at low tide were compared with PAH compounds found in adjacent groundwater-monitoring wells, point sources (combined sewer overflows [CSOs]), and surface sediments. The results indicate a strong correlation between PAH contaminant distributions in groundwater, sediment, and surface water, indicating that contaminated groundwater passing through the deeper coal tar-contaminated sediments is the primary mechanism contributing to the contamination of both surface sediment and surface water in the canal. Therefore, any sediment remediation efforts in the Gowanus Canal that fail to evaluate and control the upward transport processes have a high chance of failure due to recontamination from below. (C) 2016 Wiley Periodicals, Inc. C1 [McDonald, Shane] Louis Berger Grp Inc, Hydrogeol & Modeling, Exton, PA 19341 USA. [Gbondo-Tugbawa, Solomon] Louis Berger Grp Inc, Environm Engn & Remediat, Morristown, NJ USA. [Prabhu, Chitra; Garvey, Edward; Frederick, Jeffrey J.] Louis Berger Grp Inc, Morristown, NJ USA. [Mahoney, Eileen] New York City Dept Environm Protect, Superfund & Hazardous Mat Assessment, New York, NY USA. [Garvey, Edward] US EPA, Environm Engn Comm, Sci Advisory Board, Washington, DC 20460 USA. [Garvey, Edward] Manhattan Coll, Civil & Environm Engn Dept, New York, NY USA. RP McDonald, S (reprint author), Louis Berger Grp Inc, Hydrogeol & Modeling, Exton, PA 19341 USA. NR 23 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1051-5658 EI 1520-6831 J9 REMEDIATION JI Remediation PD FAL PY 2016 VL 26 IS 4 BP 53 EP 71 DI 10.1002/rem.21485 PG 19 WC Engineering, Environmental SC Engineering GA EE3JE UT WOS:000389482900005 ER PT J AU Fann, N Gilmore, EA Walker, K AF Fann, Neal Gilmore, Elisabeth A. Walker, Katherine TI Characterizing the Long-Term PM2.5 Concentration-Response Function: Comparing the Strengths and Weaknesses of Research Synthesis Approaches SO RISK ANALYSIS LA English DT Article DE Concentration-response function; expert elicitation; fine particulate matter (PM2.5); integrated exposure response; meta-analysis; research synthesis ID PARTICULATE AIR-POLLUTION; EXTENDED FOLLOW-UP; HARVARD 6 CITIES; LUNG-CANCER; MORTALITY; EXPOSURE; MATTER; EXAMPLE; US AB The magnitude, shape, and degree of certainty in the association between long-term population exposure to ambient fine particulate matter (PM2.5) and the risk of premature death is one of the most intensely studied issues in environmental health. For regulatory risk analysis, this relationship is described quantitatively by a concentration-response (C-R) function that relates exposure to ambient concentrations with the risk of premature mortality. Four data synthesis techniques develop the basis for, and derive, this function: systematic review, expert judgment elicitation, quantitative meta-analysis, and integrated exposure-response (IER) assessment. As part of an academic workshop aiming to guide the use of research synthesis approaches, we developed criteria with which to evaluate and select among the approaches for their ability to inform policy choices. These criteria include the quality and extent of scientific support for the method, its transparency and verifiability, its suitability to the policy problem, and the time and resources required for its application. We find that these research methods are both complementary and interdependent. A systematic review of the multidisciplinary evidence is a starting point for all methods, providing the broad conceptual basis for the nature, plausibility, and strength of the associations between PM exposure and adverse health effects. Further, for a data-rich application like PM2.5 and premature mortality, all three quantitative approaches can produce estimates that are suitable for regulatory and benefit analysis. However, when fewer data are available, more resource-intensive approaches such as expert elicitation may be more important for understanding what scientists know, where they agree or disagree, and what they believe to be the most important areas of uncertainty. Whether implicitly or explicitly, all require considerable judgment by scientists. Finding ways for all these methods to acknowledge, appropriately elicit, and examine the implications of that judgment would be an important step forward for research synthesis. C1 [Fann, Neal] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA. [Gilmore, Elisabeth A.] Univ Maryland, Sch Publ Policy, College Pk, MD 20742 USA. [Walker, Katherine] Hlth Effects Inst, 101 Fed St,Suite 500, Boston, MA 02110 USA. RP Fann, N (reprint author), US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA. EM fann.neal@epa.gov NR 33 TC 0 Z9 0 U1 5 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0272-4332 EI 1539-6924 J9 RISK ANAL JI Risk Anal. PD SEP PY 2016 VL 36 IS 9 SI SI BP 1693 EP 1707 DI 10.1111/risa.12435 PG 15 WC Public, Environmental & Occupational Health; Mathematics, Interdisciplinary Applications; Social Sciences, Mathematical Methods SC Public, Environmental & Occupational Health; Mathematics; Mathematical Methods In Social Sciences GA ED6RK UT WOS:000388983300003 PM 26269141 ER PT J AU Anenberg, SC Belova, A Brandt, J Fann, N Greco, S Guttikunda, S Heroux, ME Hurley, F Krzyzanowski, M Medina, S Miller, B Pandey, K Roos, J Van Dingenen, R AF Anenberg, Susan C. Belova, Anna Brandt, Jorgen Fann, Neal Greco, Sue Guttikunda, Sarath Heroux, Marie-Eve Hurley, Fintan Krzyzanowski, Michal Medina, Sylvia Miller, Brian Pandey, Kiran Roos, Joachim Van Dingenen, Rita TI Survey of Ambient Air Pollution Health Risk Assessment Tools SO RISK ANALYSIS LA English DT Article DE Air pollution; health impact assessment tools; mortality; ozone; particulate matter ID FINE PARTICULATE MATTER; EVA MODEL SYSTEM; HUMAN MORTALITY; PREMATURE MORTALITY; COST EXTERNALITIES; CLIMATE-CHANGE; GLOBAL BURDEN; OZONE; IMPACTS; QUALITY AB Designing air quality policies that improve public health can benefit from information about air pollution health risks and impacts, which include respiratory and cardiovascular diseases and premature death. Several computer-based tools help automate air pollution health impact assessments and are being used for a variety of contexts. Expanding information gathered for a May 2014 World Health Organization expert meeting, we survey 12 multinational air pollution health impact assessment tools, categorize them according to key technical and operational characteristics, and identify limitations and challenges. Key characteristics include spatial resolution, pollutants and health effect outcomes evaluated, and method for characterizing population exposure, as well as tool format, accessibility, complexity, and degree of peer review and application in policy contexts. While many of the tools use common data sources for concentration-response associations, population, and baseline mortality rates, they vary in the exposure information source, format, and degree of technical complexity. We find that there is an important tradeoff between technical refinement and accessibility for a broad range of applications. Analysts should apply tools that provide the appropriate geographic scope, resolution, and maximum degree of technical rigor for the intended assessment, within resources constraints. Asystematic intercomparison of the tools' inputs, assumptions, calculations, and results would be helpful to determine the appropriateness of each for different types of assessment. Future work would benefit from accounting for multiple uncertainty sources and integrating ambient air pollution health impact assessment tools with those addressing other related health risks (e.g., smoking, indoor pollution, climate change, vehicle accidents, physical activity). C1 [Anenberg, Susan C.] Environm Hlth Analyt LLC, 3704 Ingomar St NW, Washington, DC 20015 USA. [Belova, Anna] Abt Associates Inc, Bethesda, MD USA. [Brandt, Jorgen] Aarhus Univ, Dept Environm Sci, Roskilde, Denmark. [Fann, Neal] US EPA, Res Triangle Pk, NC 27711 USA. [Greco, Sue] Publ Hlth Ontario, Toronto, ON, Canada. [Guttikunda, Sarath] Desert Res Inst, Div Atmospher Sci, Reno, NV USA. [Heroux, Marie-Eve] World Hlth Org, Reg Off Europe, Bonn, Germany. [Hurley, Fintan; Miller, Brian] Inst Occupat Med, Edinburgh, Midlothian, Scotland. [Krzyzanowski, Michal] Kings Coll London, Environm Res Grp, London, England. [Medina, Sylvia] French Inst Publ Hlth Surveillance, St Maurice, France. [Pandey, Kiran] World Bank, 1818 H St NW, Washington, DC 20433 USA. [Roos, Joachim] Univ Stuttgart, Inst Energy Econ & Rat Use Energy, Stuttgart, Germany. [Van Dingenen, Rita] European Commiss, Joint Res Ctr, Inst Environm & Sustainabil, Ispra Va, Italy. RP Anenberg, SC (reprint author), Environm Hlth Analyt LLC, 3704 Ingomar St NW, Washington, DC 20015 USA. EM susan.anenberg@envhealthanalytics.com RI Brandt, Jorgen/B-3733-2011 FU World Health Organization [001] NR 66 TC 4 Z9 4 U1 12 U2 12 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0272-4332 EI 1539-6924 J9 RISK ANAL JI Risk Anal. PD SEP PY 2016 VL 36 IS 9 SI SI BP 1718 EP 1736 DI 10.1111/risa.12540 PG 19 WC Public, Environmental & Occupational Health; Mathematics, Interdisciplinary Applications; Social Sciences, Mathematical Methods SC Public, Environmental & Occupational Health; Mathematics; Mathematical Methods In Social Sciences GA ED6RK UT WOS:000388983300005 PM 26742852 ER PT J AU Shin, HH Cohen, AJ Pope, CA Ezzati, M Lim, SS Hubbell, BJ Burnett, RT AF Shin, Hwashin Hyun Cohen, Aaron J. Pope, C. Arden, III Ezzati, Majid Lim, Stephen S. Hubbell, Bryan J. Burnett, Richard T. TI Meta-Analysis Methods to Estimate the Shape and Uncertainty in the Association Between Long-Term Exposure to Ambient Fine Particulate Matter and Cause-Specific Mortality Over the Global Concentration Range SO RISK ANALYSIS LA English DT Article DE Ambient particulate matter; Bayesian analysis; Global Burden of Disease; risk distribution; uncertainty ID AMERICAN-HEART-ASSOCIATION; AIR-POLLUTION; CARDIOVASCULAR-DISEASE; RISK; STATEMENT; BURDEN; COHORT AB Estimates of excess mortality associated with exposure to ambient concentrations of fine particulate matter have been obtained from either a single cohort study or pooling information from a small number of studies. However, standard frequentist methods of pooling are known to underestimate statistical uncertainty in the true risk distribution when the number of studies pooled is small. Alternatively, Bayesian pooling methods using noninformative priors yield unrealistically large amounts of uncertainty in this case. We present a new hybrid frequentist-bayesian framework for meta-analysis that incorporates features of both frequentist and Bayesian approaches, yielding estimated uncertainty distributions that are more useful for burden estimation. We also present an example of mortality risk due to long-term exposure to ambient fine particulate matter obtained from a small number of cohort studies conducted in the United States and Europe. We compare our new risk uncertainty distribution to that obtained by the integrated exposure-response (IER) model used in the Global Burden of Disease 2010 project for which risk was modeled over the entire global concentration range. We suggest a method to incorporate our new risk uncertainty distribution based on the relatively low concentrations observed in the United States and western Europe into the IER model, thus extending risk estimation to the global concentration range. C1 [Shin, Hwashin Hyun] Bur Hlth Canada, Environm Hlth Sci & Res, Ottawa, ON, Canada. [Cohen, Aaron J.] Hlth Effects Inst, Boston, MA USA. [Pope, C. Arden, III] Brigham Young Univ, Dept Econ, Provo, UT 84602 USA. [Ezzati, Majid] Imperial Coll London, Sch Publ Hlth, London, England. [Lim, Stephen S.] Harborview Med Ctr, Dept Global Hlth, Seattle, WA USA. [Hubbell, Bryan J.] US EPA, Off Air & Radiat, Res Triangle Pk, NC 27711 USA. [Burnett, Richard T.] Hlth Canada, Populat Studies Div, 50 Columbine Driveway,Room 134, Ottawa, ON K1A 0K9, Canada. RP Burnett, RT (reprint author), Hlth Canada, Populat Studies Div, 50 Columbine Driveway,Room 134, Ottawa, ON K1A 0K9, Canada. EM rick.burnett@hc-sc.gc.ca NR 31 TC 1 Z9 1 U1 2 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0272-4332 EI 1539-6924 J9 RISK ANAL JI Risk Anal. PD SEP PY 2016 VL 36 IS 9 SI SI BP 1813 EP 1825 DI 10.1111/risa.12421 PG 13 WC Public, Environmental & Occupational Health; Mathematics, Interdisciplinary Applications; Social Sciences, Mathematical Methods SC Public, Environmental & Occupational Health; Mathematics; Mathematical Methods In Social Sciences GA ED6RK UT WOS:000388983300016 ER PT J AU Li, GQ Field, MS AF Li, Guangquan Field, Malcolm S. TI Solute Migration from the Aquifer Matrix into a Solution Conduit and the Reverse SO GROUNDWATER LA English DT Article ID FLORIDAN AQUIFER; KARST AQUIFERS; TRACER TESTS; TRANSPORT; MODEL; FLOW; EXCHANGE; WATER AB A solution conduit has a permeable wall allowing for water exchange and solute transfer between the conduit and its surrounding aquifer matrix. In this paper, we use Laplace Transform to solve a one-dimensional equation constructed using the Euler approach to describe advective transport of solute in a conduit, a production-value problem. Both nonuniform cross-section of the conduit and nonuniform seepage at the conduit wall are considered in the solution. Physical analysis using the Lagrangian approach and a lumping method is performed to verify the solution. Two-way transfer between conduit water and matrix water is also investigated by using the solution for the production-value problem as a first-order approximation. The approximate solution agrees well with the exact solution if dimensionless travel time in the conduit is an order of magnitude smaller than unity. Our analytical solution is based on the assumption that the spatial and/or temporal heterogeneity in the wall solute flux is the dominant factor in the spreading of spring-breakthrough curves, and conduit dispersion is only a secondary mechanism. Such an approach can lead to the better understanding of water exchange and solute transfer between conduits and aquifer matrix. Highlights: 1. Euler and Lagrangian approaches are used to solve transport in conduit. 2. Two-way transfer between conduit and matrix is investigated. 3. The solution is applicable to transport in conduit of persisting solute from matrix. C1 [Li, Guangquan] Yunnan Univ, Dept Geophys, Kunming 650091, Yunnan, Peoples R China. [Field, Malcolm S.] US EPA, Natl Ctr Environm Assessment 8623P, 1200 Penn Ave NW, Washington, DC 20460 USA. RP Field, MS (reprint author), US EPA, Natl Ctr Environm Assessment 8623P, 1200 Penn Ave NW, Washington, DC 20460 USA. EM guangquanli74@outlook.com; field.malcolm@epa.gov FU National Natural Science Foundation of China [41162008] FX The authors thank Dr. Maria Spassova of the Office of Research and Development of the U.S. Environmental Protection Agency for her careful review of the manuscript mathematics. The authors sincerely thank Editor-in-Chief, Henk M. Haitjema, Executive Editor, Groundwater, and the anonymous reviewers for their insightful comments and constructive suggestions, which significantly improved this paper. This research was sponsored in part by the National Natural Science Foundation of China under Grant 41162008. NR 36 TC 0 Z9 0 U1 2 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0017-467X EI 1745-6584 J9 GROUNDWATER JI Groundwater PD SEP-OCT PY 2016 VL 54 IS 5 BP 699 EP 708 DI 10.1111/gwat.12416 PG 10 WC Geosciences, Multidisciplinary; Water Resources SC Geology; Water Resources GA ED2ZS UT WOS:000388719400013 PM 26991943 ER PT J AU Arnold, BF Wade, TJ Benjamin-Chung, J Schiff, KC Griffith, JF Dufour, AP Weisberg, SB Colford, JM AF Arnold, Benjamin F. Wade, Timothy J. Benjamin-Chung, Jade Schiff, Kenneth C. Griffith, John F. Dufour, Alfred P. Weisberg, Stephen B. Colford, John M., Jr. TI Acute Gastroenteritis and Recreational Water: Highest Burden Among Young US Children SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID SWIMMING-ASSOCIATED ILLNESS; RAPIDLY MEASURED INDICATORS; GASTROINTESTINAL ILLNESS; QUALITY INDICATORS; MARINE WATER; HEALTH-RISKS; BEACHES; METAANALYSIS; PATHOGENS; EXPOSURE AB Objectives. To provide summary estimates of gastroenteritis risks and illness burden associated with recreational water exposure and determine whether children have higher risks and burden. Methods. We combined individual participant data from 13 prospective cohorts at marine and freshwater beaches throughout the United States (n = 84 411). We measured incident outcomes within 10 days of exposure: diarrhea, gastrointestinal illness, missed daily activity (work, school, vacation), and medical visits. We estimated the relationship between outcomes and 2 exposures: body immersion swimming and Enterococcus spp. fecal indicator bacteria levels in the water. We also estimated the population-attributable risk associated with these exposures. Results. Water exposure accounted for 21% of diarrhea episodes and 9% of missed daily activities but was unassociated with gastroenteritis leading to medical consultation. Children aged 0 to 4 and 5 to 10 years had the most water exposure, exhibited stronger associations between levels of water quality and illness, and accounted for the largest attributable illness burden. Conclusions. The higher gastroenteritis risk and associated burden in young children presents important new information to inform future recreational water quality guidelines designed to protect public health. C1 [Arnold, Benjamin F.; Benjamin-Chung, Jade; Colford, John M., Jr.] Univ Calif Berkeley, Sch Publ Hlth, Div Epidemiol, 101 Haviland Hall,MC 7358, Berkeley, CA 94720 USA. [Wade, Timothy J.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. [Schiff, Kenneth C.; Griffith, John F.; Weisberg, Stephen B.] Southern Calif Coastal Water Res Project, Costa Mesa, CA USA. [Dufour, Alfred P.] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. RP Arnold, BF (reprint author), Univ Calif Berkeley, Sch Publ Hlth, Div Epidemiol, 101 Haviland Hall,MC 7358, Berkeley, CA 94720 USA. EM benarnold@berkeley.edu FU National Institutes of Health (NIH) [R03-HD076066] FX This study was funded by the National Institutes of Health (NIH; grant R03-HD076066). NR 34 TC 1 Z9 1 U1 1 U2 1 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD SEP PY 2016 VL 106 IS 9 BP 1690 EP 1697 DI 10.2105/AJPH.2016.303279 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA EC4CB UT WOS:000388072300037 PM 27459461 ER PT J AU Giri, C AF Giri, Chandra TI Observation and Monitoring of Mangrove Forests Using Remote Sensing: Opportunities and Challenges SO REMOTE SENSING LA English DT Editorial Material DE mangrove forests; remote sensing; image classification; species discrimination; Landsat; radar ID CLIMATE-CHANGE; ASIAN TSUNAMI; SATELLITE; DISTRIBUTIONS; DYNAMICS; REGION; WORLD AB Mangrove forests, distributed in the tropical and subtropical regions of the world, are in a constant flux. They provide important ecosystem goods and services to nature and society. In recent years, the carbon sequestration potential and protective role of mangrove forests from natural disasters is being highlighted as an effective option for climate change adaptation and mitigation. The forests are under threat from both natural and anthropogenic forces. However, accurate, reliable, and timely information of the distribution and dynamics of mangrove forests of the world is not readily available. Recent developments in the availability and accessibility of remotely sensed data, advancement in image pre-processing and classification algorithms, significant improvement in computing, availability of expertise in handling remotely sensed data, and an increasing awareness of the applicability of remote sensing products has greatly improved our scientific understanding of changing mangrove forest cover attributes. As reported in this special issue, the use of both optical and radar satellite data at various spatial resolutions (i.e., 1 m to 30 m) to derive meaningful forest cover attributes (e.g., species discrimination, above ground biomass) is on the rise. This multi-sensor trend is likely to continue into the future providing a more complete inventory of global mangrove forest distributions and attribute inventories at enhanced temporal frequency. The papers presented in this Special Issue provide important remote sensing monitoring advancements needed to meet future scientific objectives for global mangrove forest monitoring from local to global scales. C1 [Giri, Chandra] US EPA, Sensing & Spatial Anal Branch, Off Res & Dev, 109 TW Alexander Dr, Res Triangle Pk, NC 27709 USA. RP Giri, C (reprint author), US EPA, Sensing & Spatial Anal Branch, Off Res & Dev, 109 TW Alexander Dr, Res Triangle Pk, NC 27709 USA. EM giri.chandra@epa.gov NR 22 TC 0 Z9 0 U1 20 U2 20 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 2072-4292 J9 REMOTE SENS-BASEL JI Remote Sens. PD SEP PY 2016 VL 8 IS 9 AR 783 DI 10.3390/rs8090783 PG 8 WC Remote Sensing SC Remote Sensing GA DY9XB UT WOS:000385488000093 ER PT J AU Kitchin, KT Richards, J Robinette, BL Wallace, KA Coates, NH Castellon, BT AF Kitchin, Kirk T. Richards, Judy Robinette, Brian L. Wallace, Kathleen A. Coates, Najwa H. Castellon, Benjamin T. TI Biochemical Effects of Six TiO2 and Four CeO2 Nanomaterials in HepG2 Cells SO JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY LA English DT Article DE Nanomaterial; TiO2; CeO2; Oxidative Stress; Glucose Phosphate Dehydrogenase ID TITANIUM-DIOXIDE NANOPARTICLES; CERIUM OXIDE NANOPARTICLES; OXIDATIVE STRESS; IN-VITRO; TOXICITY; MECHANISMS; STRATEGIES; PARTICLES; EXPOSURE; SAFETY AB The potential mammalian hepatotoxicity of nanomaterials were explored in dose-response and structure-activity studies with human hepatic HepG2 cells exposed to between 10 and 1000 ug/ml of six different TiO2 and four CeO2 nanomaterials for 3 days. Various biochemical parameters were then evaluated to study cytotoxicity, cell growth, hepatic function and oxidative stress. Few indications of cytotoxicity were observed between 10 and 100 ug/ml. In the 300 to 1000 ug/ml exposure range a moderate to substantial degree of cytotoxicity was observed. The percent of lactic dehydrogenase released from cells was the most sensitive cytotoxicity parameter. There were four major biochemical effects observed. By far decreased activities of glucose 6-phosphate dehydrogenase was the major finding of this enzymatic study with some significant decreases observed at 10 ug/ml. In the range of 100 to 1000 ug/ml, the activities of superoxide dismutase, glutathione reductase and glutathione peroxidase were decreased by many nanomaterials. There are six factors that contribute to substantial oxidative stress in cultured hepatocytes (decreased GSH content, and reduced G6PDH, GRD, GPX, SOD and altered catalase activities). Cytotoxicity per se did not seem to fully explain the patterns of biological responses observed. With respect to structure-activity, nanomaterials of CeO2 were more effective than TiO2 in reducing glutathione reductase and SOD activities. The nanomaterials labeled D (TiO2 from Alfa Aesar, 22 nm dry primary particle size) and M (CeO2 from NanoAmor, 8 nm) were particularly biologically active compared to other nanomaterials of the same chemical composition. Nanomaterials with 99.9% chemical identity can be surprising different in their biological effects. C1 [Kitchin, Kirk T.; Robinette, Brian L.; Wallace, Kathleen A.; Castellon, Benjamin T.] US EPA, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab, 109 Alexander Dr,Mail Drop B105-03, Res Triangle Pk, NC 27711 USA. [Richards, Judy; Coates, Najwa H.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. RP Kitchin, KT (reprint author), US EPA, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab, 109 Alexander Dr,Mail Drop B105-03, Res Triangle Pk, NC 27711 USA. RI Castellon, Benjamin/I-4117-2014 OI Castellon, Benjamin/0000-0001-8883-076X FU U. S. Environmental Protection Agency FX The information in this document has been funded wholly by the U. S. Environmental Protection Agency. It has been subjected to review by the National Health and Environmental Effects Research Laboratory and approved for publication. Approval does not signify that the contents necessarily reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 29 TC 0 Z9 0 U1 7 U2 7 PU AMER SCIENTIFIC PUBLISHERS PI VALENCIA PA 26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USA SN 1533-4880 EI 1533-4899 J9 J NANOSCI NANOTECHNO JI J. Nanosci. Nanotechnol. PD SEP PY 2016 VL 16 IS 9 BP 9505 EP 9534 DI 10.1166/jnn.2016.12166 PG 30 WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA EB1CW UT WOS:000387085000077 ER PT J AU High, M Cho, HY Marzec, J Wiltshire, T Verhein, KC Caballero, MT Acosta, PL Ciencewicki, J Mccaw, ZR Kobzik, L Miller-DeGraff, L Gladwell, W Peden, DB Serra, ME Shi, M Weinberg, C Suzuki, O Wang, XT Bell, DA Polack, FP Kleeberger, SR AF High, Monica Cho, Hye-Youn Marzec, Jacqui Wiltshire, Tim Verhein, Kirsten C. Caballero, Mauricio T. Acosta, Patricio L. Ciencewicki, Jonathan McCaw, Zackary R. Kobzik, Lester Miller-DeGraff, Laura Gladwell, Wes Peden, David B. Serra, M. Elina Shi, Min Weinberg, Clarice Suzuki, Oscar Wang, Xuting Bell, Douglas A. Polack, Fernando P. Kleeberger, Steven R. TI Determinants of host susceptibility to murine respiratory syncytial virus (RSV) disease identify a role for the innate immunity scavenger receptor MARCO gene in human infants SO EBIOMEDICINE LA English DT Article DE Infectious disease; Innate immunity; Lung; Single nucleotide polymorphism; SNP; Promoter; Haplotype ID ACUTE LUNG INJURY; INBRED MICE; VIRAL-INFECTIONS; ASSOCIATION; EXPRESSION; ASTHMA; INFLAMMATION; PARTICLES; RESPONSES; STRAINS AB Background: Respiratory syncytial virus (RSV) is the global leading cause of lower respiratory tract infection in infants. Nearly 30% of all infected infants develop severe disease including bronchiolitis, but susceptibility mechanisms remain unclear. Methods: We infected a panel of 30 inbred strains of mice with RSV and measured changes in lung disease parameters 1 and 5 days post-infection and they were used in genome-wide association (GWA) studies to identify quantitative trait loci (QTL) and susceptibility gene candidates. Findings: GWA identified QTLs for RSV disease phenotypes, and the innate immunity scavenger receptor Marco was a candidate susceptibility gene; targeted deletion of Marco worsened murine RSV disease. We characterized a human MARCO promoter SNP that caused loss of gene expression, increased in vitro cellular response to RSV infection, and associated with increased risk of disease severity in two independent populations of children infected with RSV. Interpretation: Translational integration of a genetic animal model and in vitro human studies identified a role for MARCO in human RSV disease severity. Because no RSV vaccines are approved for clinical use, genetic studies have implications for diagnosing individuals who are at risk for severe RSV disease, and disease prevention strategies (e.g. RSV antibodies). Published by Elsevier B.V. C1 [High, Monica; Cho, Hye-Youn; Marzec, Jacqui; Verhein, Kirsten C.; Ciencewicki, Jonathan; McCaw, Zackary R.; Miller-DeGraff, Laura; Gladwell, Wes; Kleeberger, Steven R.] Natl Inst Environm Hlth Sci, Immun Inflammat & Dis Lab, 111 TW Alexander Dr,Bldg 101,MD D-201, Res Triangle Pk, NC 27709 USA. [Wiltshire, Tim; Suzuki, Oscar] Univ N Carolina, Eshelman Sch Pharm, Div Pharmacotherapy & Expt Therapeut, Chapel Hill, NC USA. [Caballero, Mauricio T.; Acosta, Patricio L.; Serra, M. Elina; Polack, Fernando P.] Fdn INFANT, Buenos Aires, DF, Argentina. [Acosta, Patricio L.] Consejo Nacl Invest Cient & Tecn, Buenos Aires, DF, Argentina. [Kobzik, Lester] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA. [Peden, David B.] Univ North Carolina Chapel Hill, Ctr Environm Med Asthma & Lung Biol, Sch Med, Chapel Hill, NC USA. [Shi, Min; Weinberg, Clarice] Natl Inst Environm Hlth Sci, Biostat & Computat Biol Branch, Res Triangle Pk, NC USA. [Wang, Xuting; Bell, Douglas A.] Natl Inst Environm Hlth Sci, Genome Integr & Struct Biol Lab, Res Triangle Pk, NC USA. [Polack, Fernando P.] Vanderbilt Univ, Dept Pediat, B-3307 MCN,1161 21st Ave South, Nashville, TN USA. RP Kleeberger, SR (reprint author), Natl Inst Environm Hlth Sci, Immun Inflammat & Dis Lab, 111 TW Alexander Dr,Bldg 101,MD D-201, Res Triangle Pk, NC 27709 USA.; Polack, FP (reprint author), Vanderbilt Univ, Dept Pediat, B-3307 MCN,1161 21st Ave South, Nashville, TN USA. EM fernando.p.polack@vanderbilt.edu; kleeber1@niehs.nih.gov OI Wang, Xuting/0000-0001-6781-8008 FU NIEHS NIH HHS [P30 ES010126] NR 58 TC 0 Z9 0 U1 2 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 2352-3964 J9 EBIOMEDICINE JI EBioMedicine PD SEP PY 2016 VL 11 BP 73 EP 84 DI 10.1016/j.ebiom.2016.08.011 PG 12 WC Medicine, General & Internal SC General & Internal Medicine GA EA8II UT WOS:000386878100020 PM 27554839 ER PT J AU Flotemersch, JE Leibowitz, SG Hill, RA Stoddard, JL Thoms, MC Tharme, RE AF Flotemersch, J. E. Leibowitz, S. G. Hill, R. A. Stoddard, J. L. Thoms, M. C. Tharme, R. E. TI A Watershed Integrity Definition and Assessment Approach to Support Strategic Management of Watersheds SO RIVER RESEARCH AND APPLICATIONS LA English DT Article DE index of watershed integrity; IWI; watershed management; scale; sustainability; healthy watersheds ID ECOSYSTEM SERVICES; BIOLOGICAL INTEGRITY; CLIMATE-CHANGE; MULTIPLE STRESSORS; STREAM ECOSYSTEMS; AQUATIC STRESSORS; CENTRAL VALLEY; LAND-USE; HEALTH; RIVERS AB Watersheds are spatially explicit landscape units that contain a range of interacting physical, ecological and social attributes. They are social-ecological systems that provide a range of ecosystem services valued by the society. Their ability to provide these services depends, in part, on the degree to which they are impaired by human-related activity. An array of indicators is used by natural resource managers, both private and government, to assess watersheds and their sub-components. Often these assessments are performed in comparison with a reference condition. However, assessments can be hampered because natural settings of many systems differ from those sites used to characterize reference conditions. Additionally, given the ubiquity of human-related alterations across landscapes (e.g. atmospheric deposition of anthropogenically derived nitrogen), truly unaltered conditions for most, if not all, watersheds cannot be described. Definitions of integrity' have been developed for river ecosystems, but mainly at the reach or site scale and usually for particular species, such as fish or macroinvertebrates. These scales are inappropriate for defining integrity at the watershed scale. In addition, current assessments of endpoints do not indicate the source of impairment. Our definition of watershed integrity' is the capacity of a watershed to support and maintain the full range of ecological processes and functions essential to the sustainability of biodiversity and of the watershed resources and services provided to society. To operationalize this definition as an assessment tool, we identify key functions of unimpaired watersheds. This approach can then be used to model and map watershed integrity by incorporating risk factors (human-related alterations or stressors) that have been explicitly shown to interfere with and degrade key functions in watersheds. An advantage of this approach is that the index can be readily deconstructed to identify factors influencing index scores, thereby directly supporting the strategic adaptive management of individual components that contribute to watershed integrity. Moreover, the approach can be iteratively applied and improved as new data and information become available. (c) 2015 The Authors. River Research and Applications published by John Wiley & Sons Ltd. C1 [Flotemersch, J. E.] US EPA, Off Res & Dev, 26 W Martin Luther King Dr,Mail Stop 591, Cincinnati, OH 45268 USA. [Leibowitz, S. G.; Stoddard, J. L.] US EPA, Natl Hlth & Environm Effects Res Lab, Corvallis, OR USA. [Hill, R. A.] US EPA, ORISE Postdoc, Natl Hlth & Environm Effects Res Lab, Corvallis, OR USA. [Thoms, M. C.] Univ New England, Riverine Landscapes Res Lab, Armidale, NSW, Australia. RP Flotemersch, JE (reprint author), US EPA, Off Res & Dev, 26 W Martin Luther King Dr,Mail Stop 591, Cincinnati, OH 45268 USA. EM flotemersch.joseph@epa.gov FU American Fulbright Senior Scholarship; US Environmental Protection Agency FX We thank Tony Olsen and Marc Weber for discussions that helped shape this manuscript. We also thank Mark Bagley, Gary Davis, Thomas Fontaine, Walt Foster, Laura Gabanski, Andy Gillespie, Chuck Hawkins, Karen Metchis, Richard Mitchell, Doug Norton, Steve Paulsen, Justicia Rhodus, Murray Scown, Joseph Tiago, Suzanne van Drunick and two anonymous reviewers for comments on earlier manuscript drafts. M. T. gratefully acknowledges the support of the American Fulbright Senior Scholarship.; The information in this document has been funded entirely by the US Environmental Protection Agency, in part by an appointment to the Internship/Research Participation Program at the Office of Research and Development, U.S. Environmental Protection Agency, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and EPA. The views expressed in this journal article are those of the authors and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 152 TC 2 Z9 2 U1 13 U2 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1535-1459 EI 1535-1467 J9 RIVER RES APPL JI River Res. Appl. PD SEP PY 2016 VL 32 IS 7 BP 1654 EP 1671 DI 10.1002/rra.2978 PG 18 WC Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA DW5SF UT WOS:000383706500021 ER PT J AU Creswell, JE Carter, A Chen, B DeWild, J Fajon, V Rattonetti, A Saffari, M Tsui, MTK Zivkovic, I Braaten, HFV AF Creswell, Joel E. Carter, Annie Chen, Bin DeWild, John Fajon, Vesna Rattonetti, Anthony Saffari, Mark Tsui, Martin Tsz-Ki Zivkovic, Igor Braaten, Hans Fredrik Veiteberg TI Assessing bias in total mercury results after removing a subsample from the bottle SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY LA English DT Article DE Total mercury; sample preparation; analysis; interlaboratory comparison; oxidation method; bromine monochloride ID SPECIATION; STORAGE; PRESERVATION; SEAWATER; WATER AB U.S. EPA Method 1631 for total mercury (THg) analysis in water recommends that bromine monochloride (BrCl) be added to the original bottle in which the sample was collected, to draw into solution any Hg that may have adsorbed to the bottle walls. The method also allows for the removal of a subsample of water from the sample bottle for methylmercury (MeHg) analysis prior to adding BrCl. We have demonstrated that the removal of a subsample from the sample bottle prior to THg analysis can result in a positive concentration bias. The proposed mechanism for the bias is that 'excess' inorganic Hg, derived from the subsample that was removed from the bottle, adsorbs to the bottle walls and is then drawn into solution when BrCl is added. To test for this bias, we conducted an interlaboratory comparison study in which nine laboratories analysed water samples in fluorinated polyethylene (FLPE) bottles for THg after removing a subsample from the sample bottle, and analysed a replicate sample bottle from which no subsample was removed. We received seven complete data sets, or 63 unique sample pairs. The positive concentration bias between the bottles was significant when comparing all samples in aggregate (1.76 +/- 0.53 ng/L after subsample removal, 1.57 +/- 0.58 ng/L with no subsample removal, P < 0.05), however when comparing each of the three samples individually, the only significant bias was in the saline sample (Site UJ; 1.51 +/- 0.31 ng/L after subsample removal, 1.32 +/- 0.47 ng/L with no subsample removal, P < 0.05). Based on the findings presented here, we conclude that water chemistry, volume of water poured off, and the sample storage temperature explain some but not all of the observed bias, and we recommend collecting THg and MeHg samples in separate bottles whenever possible. C1 [Creswell, Joel E.] Brooks Rand Instruments, Seattle, WA 98107 USA. [Carter, Annie] Brooks Appl Labs, Bothell, WA USA. [Chen, Bin] PS Analyt Ltd, Orpington, England. [DeWild, John] US Geol Survey, Middleton, WI USA. [Fajon, Vesna; Zivkovic, Igor] Jozef Stefan Inst, Ljubljana, Slovenia. [Rattonetti, Anthony] San Francisco PUC, Southeast Lab, San Francisco, CA USA. [Saffari, Mark] Environm Canada PYLET, Chem Sect, N Vancouver, BC, Canada. [Tsui, Martin Tsz-Ki] Univ North Carolina Greensboro, Dept Biol, Greensboro, NC USA. [Braaten, Hans Fredrik Veiteberg] Norwegian Inst Water Res NIVA, Oslo, Norway. [Creswell, Joel E.] US EPA, Off Res & Dev, Washington, DC 20004 USA. RP Creswell, JE (reprint author), Brooks Rand Instruments, Seattle, WA 98107 USA.; Creswell, JE (reprint author), US EPA, Off Res & Dev, Washington, DC 20004 USA. EM creswell.joel@epa.gov RI Zivkovic, Igor/L-3763-2016 OI Zivkovic, Igor/0000-0003-1774-1203 FU Research Council of Norway [243644] FX This work was supported by The Research Council of Norway [Grant Number 243644]. NR 20 TC 0 Z9 0 U1 4 U2 4 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 0306-7319 EI 1029-0397 J9 INT J ENVIRON AN CH JI Int. J. Environ. Anal. Chem. PD SEP PY 2016 VL 96 IS 11 BP 1038 EP 1047 DI 10.1080/03067319.2016.1221405 PG 10 WC Chemistry, Analytical; Environmental Sciences SC Chemistry; Environmental Sciences & Ecology GA DX7HD UT WOS:000384556600003 ER PT J AU Turner, MD Henze, DK Capps, SL Hakami, A Zhao, SL Resler, J Carmichael, GR Stanier, CO Baek, J Sandu, A Russell, AG Nenes, A Pinder, RW Napelenok, SL Bash, JO Percell, PB Chai, TF AF Turner, Matthew D. Henze, Daven K. Capps, Shannon L. Hakami, Amir Zhao, Shunliu Resler, Jaroslav Carmichael, Gregory R. Stanier, Charles O. Baek, Jaemeen Sandu, Adrian Russell, Armistead G. Nenes, Athanasios Pinder, Rob W. Napelenok, Sergey L. Bash, Jesse O. Percell, Peter B. Chai, Tianfeng TI Reply to Comment on 'Premature deaths attributed to source-specific BC emissions in six urban US regions' SO ENVIRONMENTAL RESEARCH LETTERS LA English DT Editorial Material ID AIR-POLLUTION; UNITED-STATES; EXPOSURE; IMPACTS C1 [Turner, Matthew D.; Henze, Daven K.; Capps, Shannon L.] Univ Colorado, Dept Mech Engn, Boulder, CO 80309 USA. [Hakami, Amir; Zhao, Shunliu] Carleton Univ, Dept Civil & Environm Engn, Ottawa, ON K1S 5B6, Canada. [Resler, Jaroslav] Inst Comp Sci, Nonlinear Modeling, Prague 18207, Czech Republic. [Carmichael, Gregory R.; Stanier, Charles O.; Baek, Jaemeen] Univ Iowa, Dept Chem & Biochem Engn, Iowa City, IA 52242 USA. [Sandu, Adrian] Virginia Tech, Comp Sci, Blacksburg, VA 24061 USA. [Russell, Armistead G.] Georgia Tech, Sch Civil & Environm Engn, Atlanta, GA 30331 USA. [Russell, Armistead G.] Georgia Tech, Sch Earth & Atmospher Sci, Atlanta, GA 30331 USA. [Pinder, Rob W.; Napelenok, Sergey L.; Bash, Jesse O.] US EPA, Atmospher Modeling & Anal Div, Res Triangle Pk, NC 27711 USA. [Percell, Peter B.] Univ Houston, Dept Geosci, Houston, TX 77004 USA. [Chai, Tianfeng] Univ Maryland, Coll Comp Math & Nat Sci, College Pk, MD 20742 USA. RP Turner, MD (reprint author), Univ Colorado, Dept Mech Engn, Boulder, CO 80309 USA. RI Chai, Tianfeng/E-5577-2010; Capps, Shannon/E-5602-2017; Resler, Jaroslav/E-6097-2014 OI Chai, Tianfeng/0000-0003-3520-2641; Capps, Shannon/0000-0002-6872-6604; NR 10 TC 0 Z9 0 U1 5 U2 5 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 1748-9326 J9 ENVIRON RES LETT JI Environ. Res. Lett. PD SEP PY 2016 VL 11 IS 9 AR 098002 DI 10.1088/1748-9326/11/9/098002 PG 1 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA DY8PZ UT WOS:000385393600002 ER PT J AU Allen, CR Birge, HE Bartelt-Hunt, S Bevans, RA Burnett, JL Cosens, BA Cai, XM Garmestani, AS Linkov, I Scott, EA Solomon, MD Uden, DR AF Allen, Craig R. Birge, Hannah E. Bartelt-Hunt, Shannon Bevans, Rebecca A. Burnett, Jessica L. Cosens, Barbara A. Cai, Ximing Garmestani, Ahjond S. Linkov, Igor Scott, Elizabeth A. Solomon, Mark D. Uden, Daniel R. TI Avoiding Decline: Fostering Resilience and Sustainability in Midsize Cities SO SUSTAINABILITY LA English DT Article DE social-ecological systems; adaptive governance; transformative governance; cross-scale interactions; complexity; ecosystem services; resilience assessment; shrinking cities; urbanization; urban systems ID SOCIAL-ECOLOGICAL SYSTEMS; ECOSYSTEM SERVICES; GOVERNANCE; OPPORTUNITIES; CHALLENGES; MANAGEMENT AB Eighty-five percent of United States citizens live in urban areas. However, research surrounding the resilience and sustainability of complex urban systems focuses largely on coastal megacities (>1 million people). Midsize cities differ from their larger counterparts due to tight urban-rural feedbacks with their immediate natural environments that result from heavy reliance and close management of local ecosystem services. They also may be less path-dependent than larger cities due to shorter average connection length among system components, contributing to higher responsiveness among social, infrastructural, and ecological feedbacks. These distinct midsize city features call for a framework that organizes information and concepts concerning the sustainability of midsize cities specifically. We argue that an integrative approach is necessary to capture properties emergent from the complex interactions of the social, infrastructural, and ecological subsystems that comprise a city system. We suggest approaches to estimate the relative resilience of midsize cities, and include an example assessment to illustrate one such estimation approach. Resilience assessments of a midsize city can be used to examine why some cities end up on sustainable paths while others diverge to unsustainable paths, and which feedbacks may be partially responsible. They also provide insight into how city planners and decision makers can use information about the resilience of midsize cities undergoing growth or shrinkage relative to their larger and smaller counterparts, to transform them into long-term, sustainable social-ecological systems. C1 [Allen, Craig R.] Univ Nebraska, US Geol Survey, Nebraska Cooperat Fish & Wildlife Res Unit, Sch Nat Resources, Lincoln, NE 68583 USA. [Birge, Hannah E.; Bevans, Rebecca A.; Burnett, Jessica L.; Uden, Daniel R.] Univ Nebraska, Sch Nat Resources, Nebraska Cooperat Fish & Wildlife Res Unit, Lincoln, NE 68583 USA. [Bartelt-Hunt, Shannon] Univ Nebraska, Dept Civil Engn, Lincoln, NE 68583 USA. [Cosens, Barbara A.] Univ Idaho, Coll Law, Moscow, ID 83844 USA. [Cai, Ximing] Univ Illinois, Dept Civil & Environm Engn, Urbana, IL 61801 USA. [Garmestani, Ahjond S.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Linkov, Igor] US Army Corps Engineer, Engn Res & Dev Ctr, Concord, MA 01742 USA. [Scott, Elizabeth A.] Univ Idaho, Urban Design Ctr, Boise, ID 83702 USA. [Solomon, Mark D.] Univ Idaho, Idaho Water Resources Res Inst, Moscow, ID 83844 USA. RP Allen, CR (reprint author), Univ Nebraska, US Geol Survey, Nebraska Cooperat Fish & Wildlife Res Unit, Sch Nat Resources, Lincoln, NE 68583 USA. EM allencr@unl.edu; Hannah.birge@huskers.unl.edu; sbartelt2@unl.edu; bevansbecca@gmail.com; jburnett@huskers.unl.edu; bcosens@uidaho.edu; xmcai@illinois.edu; garmestani.ahjond@epa.gov; Igor.Linkov@usace.army.mil; bscott@uidaho.edu; msolomon@uidaho.edu; daniel.uden@huskers.unl.edu FU United States Geological Survey; Nebraska Game and Parks Commission; University of Nebraska-Lincoln; United States Fish and Wildlife Service; Wildlife Management Institute FX The Nebraska Cooperative Fish and Wildlife Research Unit is jointly supported by a cooperative agreement between the United States Geological Survey, the Nebraska Game and Parks Commission, the University of Nebraska-Lincoln, the United States Fish and Wildlife Service, and the Wildlife Management Institute. NR 53 TC 1 Z9 1 U1 32 U2 32 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 2071-1050 J9 SUSTAINABILITY-BASEL JI Sustainability PD SEP PY 2016 VL 8 IS 9 AR 844 DI 10.3390/su8090844 PG 24 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Environmental Sciences; Environmental Studies SC Science & Technology - Other Topics; Environmental Sciences & Ecology GA DZ0LC UT WOS:000385529400016 ER PT J AU Herrmann, DL Shuster, WD Mayer, AL Garmestani, AS AF Herrmann, Dustin L. Shuster, William D. Mayer, Audrey L. Garmestani, Ahjond S. TI Sustainability for Shrinking Cities SO SUSTAINABILITY LA English DT Editorial Material DE shrinking cities; panarchy; sustainable city; urban systems ID UNITED-STATES; CITY; PERSPECTIVES; URBANISM; SYSTEMS; SIZE AB Shrinking cities are widespread throughout the world despite the rapidly increasing global urban population. These cities are attempting to transition to sustainable trajectories to improve the health and well-being of urban residents, to build their capacity to adapt to changing conditions and to cope with major events. The dynamics of shrinking cities are different than the dynamics of growing cities, and therefore intentional research and planning around creating sustainable cities is needed for shrinking cities. We propose research that can be applied to shrinking cities by identifying parallel challenges in growing cities and translating urban research and planning that is specific to each city's dynamics. In addition, we offer applications of panarchy concepts to this problem. The contributions to this Special Issue take on this forward-looking planning task through drawing lessons for urban sustainability from shrinking cities, or translating general lessons from urban research to the context of shrinking cities. C1 [Herrmann, Dustin L.] US EPA, Oak Ridge Inst Sci & Educ, Res Participant Program, Cincinnati, OH 45268 USA. [Shuster, William D.; Garmestani, Ahjond S.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Mayer, Audrey L.] Michigan Technol Univ, Dept Social Sci, Houghton, MI 49931 USA. [Mayer, Audrey L.] Michigan Technol Univ, Sch Forest Resources & Environm Sci, Houghton, MI 49931 USA. RP Herrmann, DL (reprint author), US EPA, Oak Ridge Inst Sci & Educ, Res Participant Program, Cincinnati, OH 45268 USA. EM herrmann.dustin@epa.gov; shuster.william@epa.gov; almayer@mtu.edu; garmestani.ahjond@epa.gov OI Herrmann, Dustin/0000-0002-4227-8196; Mayer, Audrey/0000-0003-3278-1182 FU Oak Ridge Institute for Science and Education through the US Department of Energy; US Environmental Protection Agency FX Partial support was provided to D.L. Herrmann through an appointment to the research participation program with the Oak Ridge Institute for Science and Education through the US Department of Energy and US Environmental Protection Agency. The views expressed in this article are strictly the opinions of the authors and in no manner represent or reflect current or planned policy by the US Environmental Protection Agency or other Federal agencies. NR 51 TC 0 Z9 0 U1 14 U2 14 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 2071-1050 J9 SUSTAINABILITY-BASEL JI Sustainability PD SEP PY 2016 VL 8 IS 9 AR 911 DI 10.3390/su8090911 PG 9 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Environmental Sciences; Environmental Studies SC Science & Technology - Other Topics; Environmental Sciences & Ecology GA DZ0LC UT WOS:000385529400083 ER PT J AU Duan, S Newcomer-Johnson, T Mayer, P Kaushal, S AF Duan, Shuiwang Newcomer-Johnson, Tamara Mayer, Paul Kaushal, Sujay TI Phosphorus Retention in Stormwater Control Structures across Streamflow in Urban and Suburban Watersheds SO WATER LA English DT Article DE phosphorus; stormwater control measures; urbanization; nutrient management; green infrastructure ID NUTRIENT RETENTION; POLLUTANT REMOVAL; NITROGEN FLUXES; DEGRADED URBAN; ORGANIC-CARBON; RESTORATION; DENITRIFICATION; PHOSPHATE; SEDIMENTS; DYNAMICS AB Recent studies have shown that stormwater control measures (SCMs) are less effective at retaining phosphorus (P) than nitrogen. We compared P retention between two urban/suburban SCMs and their adjacent free-flowing stream reaches at the Baltimore Long-Term Ecological Study (LTER) site, and examined changes in P retention in SCMs across flow conditions. Results show that, when compared with free-flowing stream reaches, the SCMs had significantly lower dissolved oxygen (%DO) and higher P concentrations, as well as lower mean areal retention rates and retention efficiencies of particulate P (PP). In all the SCMs, concentrations of total dissolved phosphorus (TDP) consistently exhibited inverse correlations with %DO that was lower during summer base flows. Particulate phosphorus (PP) concentrations peaked during spring high flow period in both streams and in-line pond/SCMs, but they were also higher during summer base flows in suburban/urban SCMs. Meanwhile, PP areal retention rates and retention efficiencies of the SCMs changed from positive (indicating retention) during high flows to negative (indicating release) during low flows, while such changes across flow were not observed in free-flowing stream reaches. We attribute the changing roles of SCMs from a PP sink to a PP source to changes in SCM hydrologic mass balances, physical sedimentation and biogeochemical mobilization across flows. This study demonstrates that in suburban/urban SCMs, P retained during high flow events can be released during low flows. Cultivation of macrophytes and/or frequent sediment dredging may provide potential solutions to retaining both P and nitrogen in urban SCMs. C1 [Duan, Shuiwang; Newcomer-Johnson, Tamara; Kaushal, Sujay] Univ Maryland, Dept Geol, College Pk, MD 20742 USA. [Duan, Shuiwang; Newcomer-Johnson, Tamara; Kaushal, Sujay] Univ Maryland, Earth Syst Sci Interdisciplinary Ctr, College Pk, MD 20742 USA. [Newcomer-Johnson, Tamara] US EPA, Syst Exposure Div, Ecosyst Integr Branch, Cincinnati, OH 45268 USA. [Mayer, Paul] US EPA, Western Ecol Div, Natl Hlth & Environm Effects Res Lab, Corvallis, OR 97333 USA. RP Duan, S (reprint author), Univ Maryland, Dept Geol, College Pk, MD 20742 USA.; Duan, S (reprint author), Univ Maryland, Earth Syst Sci Interdisciplinary Ctr, College Pk, MD 20742 USA. EM sduan@umd.edu; newcomer-johnson.tammy@epa.gov; Mayer.Paul@epa.gov; skaushal@umd.edu RI Newcomer Johnson, Tamara/D-1045-2013 OI Newcomer Johnson, Tamara/0000-0002-2496-7641 FU MD Sea Grant Awards [SA7528085-U, R/WS-2, NA05OAR4171042]; NSF [DBI 0640300, CBET 1058502, EAR 1427000, EAR 1521224]; EPA NNEMS [2010-308]; NASA [NASA NNX11AM28G]; Baltimore Ecosystem Study LTER project [NSF DEB-0423476] FX This research was supported by MD Sea Grant Awards SA7528085-U, R/WS-2 and NA05OAR4171042; NSF Awards DBI 0640300, CBET 1058502, EAR 1427000, EAR 1521224, EPA NNEMS Award 2010-308, NASA grant NASA NNX11AM28G; and Baltimore Ecosystem Study LTER project (NSF DEB-0423476). We thank Melanie Harrison Okoro, Jeff Campbell, Katie Newcomb, Gwen Sivirichi, Michael Pennino, Dan Dillon, Casie Smith, and Rich Foot for assistance in the lab and field. The research has been subjected to U.S. Environmental Protection Agency review but does not necessarily reflect the views of any of the funding agencies, and no official endorsement should be inferred. NR 51 TC 0 Z9 0 U1 11 U2 11 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 2073-4441 J9 WATER-SUI JI Water PD SEP PY 2016 VL 8 IS 9 AR 390 DI 10.3390/w8090390 PG 17 WC Water Resources SC Water Resources GA DY9VE UT WOS:000385482400030 ER PT J AU Angrish, M Padilla, S Chorley, BN Tennant, AH AF Angrish, M. Padilla, S. Chorley, B. N. Tennant, A. H. TI Fetal Origins of Life Stage Disease: A Zebrafish Model for the Obesity Epidemic. SO ENVIRONMENTAL AND MOLECULAR MUTAGENESIS LA English DT Meeting Abstract CT 47th Annual Meeting of the Environmental-Mutagenesis-and-Genomics-Society CY SEP 24-28, 2016 CL Kansas City, MO SP Environm Mutagenesis & Genom Soc C1 [Angrish, M.; Padilla, S.; Chorley, B. N.; Tennant, A. H.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0893-6692 EI 1098-2280 J9 ENVIRON MOL MUTAGEN JI Environ. Mol. Mutagen. PD SEP PY 2016 VL 57 SU 1 MA EG-28 BP S62 EP S62 PG 1 WC Environmental Sciences; Genetics & Heredity; Toxicology SC Environmental Sciences & Ecology; Genetics & Heredity; Toxicology GA DW4BQ UT WOS:000383587400091 ER PT J AU Dunnick, KM Doheny, DL Rowley, S Ross, SM Deisenroth, C Clewell, RA AF Dunnick, K. M. Doheny, D. L. Rowley, S. Ross, S. M. Deisenroth, C. Clewell, R. A. TI Development of Direct Double-Strand Break Labeling Assay. SO ENVIRONMENTAL AND MOLECULAR MUTAGENESIS LA English DT Meeting Abstract CT 47th Annual Meeting of the Environmental-Mutagenesis-and-Genomics-Society CY SEP 24-28, 2016 CL Kansas City, MO SP Environm Mutagenesis & Genom Soc C1 [Dunnick, K. M.; Doheny, D. L.; Rowley, S.; Ross, S. M.; Clewell, R. A.] ScitoVation, Res Triangle Pk, NC USA. [Deisenroth, C.] US EPA, Res Triangle Pk, NC 27711 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0893-6692 EI 1098-2280 J9 ENVIRON MOL MUTAGEN JI Environ. Mol. Mutagen. PD SEP PY 2016 VL 57 SU 1 MA DR-4 BP S58 EP S58 PG 1 WC Environmental Sciences; Genetics & Heredity; Toxicology SC Environmental Sciences & Ecology; Genetics & Heredity; Toxicology GA DW4BQ UT WOS:000383587400077 ER PT J AU Hines, RN Chorley, BN AF Hines, R. N. Chorley, B. N. TI Application of miRNAs as Biomarkers of Exposure and Effects in Risk Evaluation. SO ENVIRONMENTAL AND MOLECULAR MUTAGENESIS LA English DT Meeting Abstract CT 47th Annual Meeting of the Environmental-Mutagenesis-and-Genomics-Society CY SEP 24-28, 2016 CL Kansas City, MO SP Environm Mutagenesis & Genom Soc C1 [Hines, R. N.; Chorley, B. N.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0893-6692 EI 1098-2280 J9 ENVIRON MOL MUTAGEN JI Environ. Mol. Mutagen. PD SEP PY 2016 VL 57 SU 1 MA S42 BP S50 EP S50 PG 1 WC Environmental Sciences; Genetics & Heredity; Toxicology SC Environmental Sciences & Ecology; Genetics & Heredity; Toxicology GA DW4BQ UT WOS:000383587400050 ER PT J AU Olden, K Lin, YS AF Olden, K. Lin, Y-S TI Epigenome: A Biomarker of Cumulative Exposure to Chemical and Nonchemical Stressors over the Lifecourse. SO ENVIRONMENTAL AND MOLECULAR MUTAGENESIS LA English DT Meeting Abstract CT 47th Annual Meeting of the Environmental-Mutagenesis-and-Genomics-Society CY SEP 24-28, 2016 CL Kansas City, MO SP Environm Mutagenesis & Genom Soc C1 [Olden, K.; Lin, Y-S] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Washington, DC 20460 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0893-6692 EI 1098-2280 J9 ENVIRON MOL MUTAGEN JI Environ. Mol. Mutagen. PD SEP PY 2016 VL 57 SU 1 MA S27 BP S46 EP S46 PG 1 WC Environmental Sciences; Genetics & Heredity; Toxicology SC Environmental Sciences & Ecology; Genetics & Heredity; Toxicology GA DW4BQ UT WOS:000383587400033 ER PT J AU Preston, RJ AF Preston, R. J. TI International Organizations, Risk Assessment and Research: Why, What, and How SO ENVIRONMENTAL AND MOLECULAR MUTAGENESIS LA English DT Meeting Abstract CT 47th Annual Meeting of the Environmental-Mutagenesis-and-Genomics-Society CY SEP 24-28, 2016 CL Kansas City, MO SP Environm Mutagenesis & Genom Soc C1 [Preston, R. J.] US EPA, Res Triangle Pk, NC 27711 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0893-6692 EI 1098-2280 J9 ENVIRON MOL MUTAGEN JI Environ. Mol. Mutagen. PD SEP PY 2016 VL 57 SU 1 MA S51 BP S52 EP S52 PG 1 WC Environmental Sciences; Genetics & Heredity; Toxicology SC Environmental Sciences & Ecology; Genetics & Heredity; Toxicology GA DW4BQ UT WOS:000383587400059 ER EF