FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Cheng, SY Zhang, YE AF Cheng, Steven Y. Zhang, Ying E. TI Smurfs have "fused" into the asymmetric division of stem cells SO PROTEIN & CELL LA English DT News Item ID DROSOPHILA OVARY; HEDGEHOG C1 [Cheng, Steven Y.] Nanjing Med Univ, Dept Dev Genet, Ctr Regenerat Med, Nanjing 210029, Jiangsu, Peoples R China. [Zhang, Ying E.] NCI, Lab Cellular & Mol Biol, NIH, Bethesda, MD 20892 USA. RP Cheng, SY (reprint author), Nanjing Med Univ, Dept Dev Genet, Ctr Regenerat Med, 140 Hanzhong Rd, Nanjing 210029, Jiangsu, Peoples R China. EM sycheng@njmu.edu.cn RI Zhang, Ying/G-3657-2015 OI Zhang, Ying/0000-0003-2753-7601 FU Intramural NIH HHS [ZIA BC011168-02] NR 8 TC 1 Z9 1 U1 0 U2 3 PU HIGHER EDUCATION PRESS PI BEIJING PA SHATANHOU ST 55, BEIJING 100009, PEOPLES R CHINA SN 1674-800X EI 1674-8018 J9 PROTEIN CELL JI Protein Cell PD JAN PY 2011 VL 2 IS 1 BP 2 EP 4 DI 10.1007/s13238-011-1005-6 PG 3 WC Cell Biology SC Cell Biology GA 029TS UT WOS:000310519400002 PM 21337003 ER PT J AU Kish, LB Khatri, SP Bezrukov, SM Peper, F Gingl, Z Horvath, T AF Kish, Laszlo B. Khatri, Sunil P. Bezrukov, Sergey M. Peper, Ferdinand Gingl, Zoltan Horvath, Tamas BE Deen, MJ Chen, CH TI Noise-based Information Processing Noise-based logic and computing: what do we have so far? SO 2011 21ST INTERNATIONAL CONFERENCE ON NOISE AND FLUCTUATIONS (ICNF) LA English DT Proceedings Paper CT 21st International Conference on Noise and Fluctuations (ICNF) CY JUN 12-16, 2011 CL Toronto, CANADA SP McMaster Univ, Ryerson Univ, Univ Texas, IEEE Hamilton Sect, IEEE Elect Devices Soc, IEEE Toronto Sect, IEEE DE Deterministic logic; multivalued logic; brain mimetics; noise as information carrier ID ENERGY; SUPERPOSITION; SPIKES; STATES AB We briefly introduce noise-based logic. After describing the main motivations we outline classical, instantaneous (squeezed and non-squeezed), continuum, spike and random-telegraph-signal based schemes with applications such as circuits that emulate the brain functioning and string verification via a slow communication channel. C1 [Kish, Laszlo B.; Khatri, Sunil P.] Texas A&M Univ, Dept Elect & Comp Engn, College Stn, TX 77843 USA. [Bezrukov, Sergey M.] NIH, NIHCD, Lab Phys & Struct Biol Program Phys Biol, Bethesda, MD 20892 USA. [Peper, Ferdinand] Natl Inst Informat & Commun Technol, Kobe, Hyogo 6512492, Japan. [Gingl, Zoltan] Univ Szeged, Dept Expt Phys, H-6720 Szeged, Hungary. [Horvath, Tamas] Univ Bonn, Dept Comp Sci, Bonn, Germany. [Horvath, Tamas] Schloss Birlinghoven, Fraunhofer IAIS, D-53754 St Augustin, Germany. RP Kish, LB (reprint author), Texas A&M Univ, Dept Elect & Comp Engn, College Stn, TX 77843 USA. OI Gingl, Zoltan/0000-0001-6570-2685 NR 21 TC 0 Z9 0 U1 1 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4577-0192-4 PY 2011 BP 28 EP 33 PG 6 WC Engineering, Electrical & Electronic SC Engineering GA BCC62 UT WOS:000309730300006 ER PT J AU Wu, MC Forbes, JG Wang, K AF Wu, Ming-Chya Forbes, Jeffrey G. Wang, Kuan BE Deen, MJ Chen, CH TI Cross-correlation analysis to salt-bridge dynamics in force-induced unfolding of titin kinase SO 2011 21ST INTERNATIONAL CONFERENCE ON NOISE AND FLUCTUATIONS (ICNF) LA English DT Proceedings Paper CT 21st International Conference on Noise and Fluctuations (ICNF) CY JUN 12-16, 2011 CL Toronto, CANADA SP McMaster Univ, Ryerson Univ, Univ Texas, IEEE Hamilton Sect, IEEE Elect Devices Soc, IEEE Toronto Sect, IEEE ID TIME-SERIES AB In this paper, a theoretical study on the salt-bridge dynamics of titin kinase is presented. We focus on the analysis of the spatial-temporal properties of the salt-bridge time series of titin kinase in force-induced unfolding simulated by steered molecular dynamics (SMD). Salt-bridge time series are defined from the SMD trajectories. Scaling analysis reveals two characteristics of the time series in short and long time scales, suggesting there is anti-persistent behavior in short-time scale less than 50 ps, while persistent behavior dominates in longtime scale larger than 100 ps. Using cross-correlation analysis, we study the dynamics of the salt-bridges. From analyzing the eigenvectors of the cross-correlation matrix constructed by the salt-bridge data, we classify salt-bridges into distinct groups. The knowledge of the grouping is useful in identifying force-relevant structural transitions. C1 [Wu, Ming-Chya] Natl Cent Univ, Res Ctr Adapt Data Anal, Chungli 32001, Taiwan. [Forbes, Jeffrey G.] NIH, NIAMSD, Bethesda, MD 20892 USA. [Wang, Kuan] Acad Sinica, Inst Biol Chem, Taipei 11529, Taiwan. RP Wu, MC (reprint author), Natl Cent Univ, Res Ctr Adapt Data Anal, Chungli 32001, Taiwan. EM mcwu@ncu.edu.tw FU National Science Council of the Republic of China (Taiwan) [NSC 96-2112-M-008-021-MY3, 97-2627-B-008-004, 98-2627-B-008-004, 99-2627-B-008-002]; National Center for Theoretical Sciences at National Taiwan University FX This work was supported by the National Science Council of the Republic of China (Taiwan) under Grant Nos. NSC 96-2112-M-008-021-MY3, 97-2627-B-008-004, 98-2627-B-008-004, and 99-2627-B-008-002, and National Center for Theoretical Sciences at National Taiwan University. NR 12 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4577-0192-4 PY 2011 BP 429 EP 432 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA BCC62 UT WOS:000309730300105 ER PT J AU Resnick, SM Sojkova, J AF Resnick, Susan M. Sojkova, Jitka TI Amyloid imaging and memory change for prediction of cognitive impairment SO ALZHEIMERS RESEARCH & THERAPY LA English DT Review ID PITTSBURGH COMPOUND-B; PRECLINICAL ALZHEIMERS-DISEASE; NONDEMENTED INDIVIDUALS; PIB-PET; DEPOSITION; BETA; PATHOLOGY; DECLINE; RESERVE; HYPERTROPHY AB PET radiotracers for in vivo measurement of beta-amyloid (A beta) deposition throughout the brain are contributing to early detection of the neuropathology associated with Alzheimer's disease and enhancing prediction of individuals most likely to develop cognitive impairment and dementia. However, the fact that 30 to 50% of cognitively normal older adults have varying but detectable levels of A beta poses challenges and opportunities in using amyloid imaging in research and clinical applications. In this review, we summarize studies of the relationship between A beta burden and cognitive status in impaired and unimpaired individuals and the relationship between A beta burden and cognitive function. We conclude by operationalizing the way in which information on imaging-assessed A beta burden and cognitive performance can be used jointly to improve prediction of clinical outcomes, to enhance understanding of the role of A beta deposition in cognitive impairment, and to identify factors that promote cognitive resilience in the presence of A beta. C1 [Resnick, Susan M.; Sojkova, Jitka] NIA, Lab Behav Neurosci, NIH Biomed Res Ctr, IRP, Baltimore, MD 21224 USA. [Sojkova, Jitka] Johns Hopkins Univ, Russell H Morgan Dept Radiol & Radiol Sci, Sch Med, Baltimore, MD 21287 USA. RP Resnick, SM (reprint author), NIA, Lab Behav Neurosci, NIH Biomed Res Ctr, IRP, 251 Bayview Blvd,Room 4B335, Baltimore, MD 21224 USA. EM resnicks@grc.nia.nih.gov FU Intramural Research Program of the NIH, National Institute on Aging; [N01-AG-3-2124] FX This research was supported by the Intramural Research Program of the NIH, National Institute on Aging and N01-AG-3-2124. NR 54 TC 14 Z9 14 U1 1 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1758-9193 J9 ALZHEIMERS RES THER JI Alzheimers Res. Ther. PY 2011 VL 3 IS 1 AR 3 DI 10.1186/alzrt62 PG 9 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 024XJ UT WOS:000310144700003 PM 21345176 ER PT J AU Shineman, DW Basi, GS Bizon, JL Colton, CA Greenberg, BD Hollister, BA Lincecum, J Leblanc, GG Lee, LH Luo, F Morgan, D Morse, I Refolo, LM Riddell, DR Scearce-Levie, K Sweeney, P Yrjanheikki, J Fillit, HM AF Shineman, Diana W. Basi, Guriqbal S. Bizon, Jennifer L. Colton, Carol A. Greenberg, Barry D. Hollister, Beth A. Lincecum, John Leblanc, Gabrielle G. Lee, Linda (Bobbi) H. Luo, Feng Morgan, Dave Morse, Iva Refolo, Lorenzo M. Riddell, David R. Scearce-Levie, Kimberly Sweeney, Patrick Yrjanheikki, Juha Fillit, Howard M. TI Accelerating drug discovery for Alzheimer's disease: best practices for preclinical animal studies SO ALZHEIMERS RESEARCH & THERAPY LA English DT Review ID AMYLOID-PRECURSOR-PROTEIN; TRANSGENIC MICE; A-BETA; MOUSE MODEL; COGNITIVE DECLINE; NEUROFIBRILLARY DEGENERATION; MEMORY IMPAIRMENT; PLAQUE-FORMATION; MUTANT FORM; EARLY-ONSET AB Animal models have contributed significantly to our understanding of the underlying biological mechanisms of Alzheimer's disease (AD). As a result, over 300 interventions have been investigated and reported to mitigate pathological phenotypes or improve behavior in AD animal models or both. To date, however, very few of these findings have resulted in target validation in humans or successful translation to disease-modifying therapies. Challenges in translating preclinical studies to clinical trials include the inability of animal models to recapitulate the human disease, variations in breeding and colony maintenance, lack of standards in design, conduct and analysis of animal trials, and publication bias due to under-reporting of negative results in the scientific literature. The quality of animal model research on novel therapeutics can be improved by bringing the rigor of human clinical trials to animal studies. Research communities in several disease areas have developed recommendations for the conduct and reporting of preclinical studies in order to increase their validity, reproducibility, and predictive value. To address these issues in the AD community, the Alzheimer's Drug Discovery Foundation partnered with Charles River Discovery Services (Morrisville, NC, USA) and Cerebricon Ltd. (Kuopio, Finland) to convene an expert advisory panel of academic, industry, and government scientists to make recommendations on best practices for animal studies testing investigational AD therapies. The panel produced recommendations regarding the measurement, analysis, and reporting of relevant AD targets, the choice of animal model, quality control measures for breeding and colony maintenance, and preclinical animal study design. Major considerations to incorporate into preclinical study design include a priori hypotheses, pharmacokinetics-pharmacodynamics studies prior to proof-of-concept testing, biomarker measurements, sample size determination, and power analysis. The panel also recommended distinguishing between pilot 'exploratory' animal studies and more extensive 'therapeutic' studies to guide interpretation. Finally, the panel proposed infrastructure and resource development, such as the establishment of a public data repository in which both positive animal studies and negative ones could be reported. By promoting best practices, these recommendations can improve the methodological quality and predictive value of AD animal studies and make the translation to human clinical trials more efficient and reliable. C1 [Shineman, Diana W.; Lee, Linda (Bobbi) H.; Fillit, Howard M.] Alzheimers Drug Discovery Fdn, New York, NY 10019 USA. [Basi, Guriqbal S.] Elan Pharmaceut, San Francisco, CA 94080 USA. [Bizon, Jennifer L.] Univ Florida, Evelyn F & William L McKnight Brain Inst, Gainesville, FL 32610 USA. [Colton, Carol A.] Duke Univ, Med Ctr, Durham, NC 27710 USA. [Greenberg, Barry D.] Univ Hlth Network, Toronto Western Res Inst, Toronto, ON M5T 2S8, Canada. [Hollister, Beth A.] Charles River Discovery Serv, Morrisville, NC 27560 USA. [Lincecum, John] ALS Therapy Dev Inst, Cambridge, MA 02142 USA. [Leblanc, Gabrielle G.] Leblanc Neurosci Consulting, Berkeley, CA 94708 USA. [Lee, Linda (Bobbi) H.] Columbia Univ, New York, NY 10032 USA. [Luo, Feng] Abbott Neurosci, Abbott Pk, IL 60064 USA. [Morgan, Dave] Univ S Florida, USF Hlth Byrd Alzheimer Inst, Tampa, FL 33613 USA. [Morse, Iva] Charles River Labs Inc, Genetically Engineered Models & Serv, Wilmington, MA 01887 USA. [Refolo, Lorenzo M.] NIA, Bethesda, MD 20892 USA. [Riddell, David R.] Pfizer Neurosci Res Unit, Groton, CT 06340 USA. [Scearce-Levie, Kimberly] Genentech Inc, San Francisco, CA 94080 USA. [Sweeney, Patrick; Yrjanheikki, Juha] Cerebricon Ltd, Charles River Discovery Serv, Kuopio 70210, Finland. RP Shineman, DW (reprint author), Alzheimers Drug Discovery Fdn, 57 West 57 St,Suite 904, New York, NY 10019 USA. EM dshineman@alzdiscovery.org RI Morgan, David/J-5989-2012 FU Charles River CHARTER (Commitment to Humane Animal Research Through Excellence and Responsibility) program FX We would like to convey our appreciation to key members of the Alzheimer's Drug Discovery Foundation staff for their support in this effort. In particular, we thank Filomena Machleder, Adam Liebling, and Hannah Elkin. We are also grateful to the Charles River CHARTER (Commitment to Humane Animal Research Through Excellence and Responsibility) program for providing funding. NR 67 TC 41 Z9 41 U1 0 U2 18 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1758-9193 J9 ALZHEIMERS RES THER JI Alzheimers Res. Ther. PY 2011 VL 3 IS 5 AR 28 DI 10.1186/alzrt90 PG 13 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 024XW UT WOS:000310146100003 PM 21943025 ER PT J AU Wang, PS Aguilar-Gaxiola, S Alonso, J Lee, S Schoenbaum, M Ustun, TB Kessler, RC Bruffaerts, R Borges, G de Girolamo, G Gureje, O Haro, JM Kostyuchenko, S Masfety, VK Levinson, D Matschinger, H Mneimneh, Z Browne, MO Ormel, J Posada-Villa, J Seedat, S Tachimori, H Tsang, A AF Wang, Philip S. Aguilar-Gaxiola, Sergio Alonso, Jordi Lee, Sing Schoenbaum, Michael Uestuen, T. Bedirhan Kessler, Ronald C. Bruffaerts, Ronny Borges, Guilherme de Girolamo, Giovanni Gureje, Oye Haro, Josep Maria Kostyuchenko, Stanislav Masfety, Viviane Kovess Levinson, Daphna Matschinger, Herbert Mneimneh, Zeina Browne, Mark Oakley Ormel, Johan Posada-Villa, Jose Seedat, Soraya Tachimori, Hisateru Tsang, Adley BE Regier, DA Narrow, WE Kuhl, EA Kupfer, DJ TI Assessing Mental Disorders and Service Use Across Countries The WHO World Mental Health Survey Initiative SO CONCEPTUAL EVOLUTION OF DSM-5 LA English DT Article; Book Chapter ID NATIONAL-COMORBIDITY-SURVEY; R PSYCHIATRIC-DISORDERS; REPLICATION NCS-R; UNITED-STATES; 12-MONTH PREVALENCE; LIFETIME PREVALENCE; GENERAL-POPULATION; SUICIDE ATTEMPTS; CATCHMENT-AREA; SOCIAL PHOBIA C1 [Wang, Philip S.; Schoenbaum, Michael] NIMH, Div Serv & Intervent Res, Bethesda, MD 20892 USA. [Aguilar-Gaxiola, Sergio] Univ Calif, Ctr Reducing Hlth Dispar, Davis Sch Med, Sacamento, CA USA. [Lee, Sing] Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China. [Uestuen, T. Bedirhan] World Hlth Org, Geneva, Switzerland. [Kessler, Ronald C.] Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA. [Bruffaerts, Ronny] Katholieke Univ Leuven, Dept Neurosci, Louvain, Belgium. [Borges, Guilherme] Natl Inst Psychiat Mexico, Dept Epidemiol Res, Div Epidemiol & Psychosocial Res, Mexico City, DF, Mexico. [Borges, Guilherme] Metropolitan Autonomous Univ, Mexico City, DF, Mexico. [Gureje, Oye] Univ Ibadan, Dept Psychiat, Univ Coll Hosp, Ibadan, Nigeria. [Matschinger, Herbert] Univ Leipzig, Dept Psychiat & Psychotherapy, Leipzig, Germany. [Mneimneh, Zeina] Univ Michigan, Inst Social Res, Survey Res Ctr, Ann Arbor, MI USA. [Browne, Mark Oakley] Univ Tasmania, Discipline Psychiat, Sch Med, Hobart, Tas 7001, Australia. [Ormel, Johan] Univ Med Ctr Groningen, Groningen, Netherlands. [Seedat, Soraya] MRC, Unit Anxiety & Stress Disorders, Cape Town, South Africa. [Tachimori, Hisateru] NIMH, Natl Ctr Neurol & Psychiat, Bethesda, MD 20892 USA. [Tsang, Adley] Prince Wales Hosp, Hong Kong Mood Disorders Ctr, Hong Kong, Hong Kong, Peoples R China. RP Wang, PS (reprint author), NIMH, Div Serv & Intervent Res, Bethesda, MD 20892 USA. RI Lee, Sing/O-2136-2015 NR 85 TC 0 Z9 0 U1 4 U2 8 PU AMER PSYCHIATRIC PRESS, INC PI WASHINGTON PA 1400 K ST NW, WASHINGTON, DC 20005 USA BN 978-1-58562-388-4 PY 2011 BP 231 EP 266 PG 36 WC Psychology, Clinical; Psychiatry; Psychology SC Psychology; Psychiatry GA BCF30 UT WOS:000310051000012 ER PT J AU Pine, DS Costello, EJ Dahl, R James, R Leckman, JF Leibenluft, E Klein, RG Rapoport, JL Shaffer, D Taylor, E Zeanah, CH AF Pine, Daniel S. Costello, E. Jane Dahl, Ron James, Regina Leckman, James F. Leibenluft, Ellen Klein, Rachel G. Rapoport, Judith L. Shaffer, David Taylor, Eric Zeanah, Charles H. BE Regier, DA Narrow, WE Kuhl, EA Kupfer, DJ TI Increasing the Developmental Focus in DSM-5 Broad Issues and Specific Potential Applications in Anxiety SO CONCEPTUAL EVOLUTION OF DSM-5 LA English DT Article; Book Chapter ID OBSESSIVE-COMPULSIVE DISORDER; BEHAVIORAL-INHIBITION; SOCIAL-ANXIETY; PANIC DISORDER; CHILDREN; ADOLESCENTS; RISK; DEPRESSION; CHILDHOOD; LIFE C1 [Pine, Daniel S.; Leibenluft, Ellen] NIMH, Sect Bipolar Spectrum Disorders, Emot & Dev Branch, Mood & Anxiety Program, Bethesda, MD 20892 USA. [Costello, E. Jane] Duke Univ, Sch Med, Dept Psychiat & Behav Sci, Ctr Dev Epidemiol, Durham, NC USA. [Dahl, Ron] Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin, Pittsburgh, PA USA. [James, Regina] NICHHD, Div Special Populat, Bethesda, MD 20892 USA. [Leckman, James F.] Yale Univ, Sch Med, Yale Child Study Ctr, New Haven, CT USA. [Klein, Rachel G.] NYU, Ctr Child Study, New York, NY USA. [Rapoport, Judith L.] NIMH, Child Psychiat Branch, Bethesda, MD 20892 USA. [Shaffer, David] New York State Psychiat Inst & Hosp, New York, NY 10032 USA. [Taylor, Eric] Kings Coll London, Inst Psychiat, London WC2R 2LS, England. [Zeanah, Charles H.] Tulane Univ, Dept Psychiat, New Orleans, LA 70118 USA. RP Pine, DS (reprint author), NIMH, Sect Bipolar Spectrum Disorders, Emot & Dev Branch, Mood & Anxiety Program, Bethesda, MD 20892 USA. NR 34 TC 9 Z9 10 U1 0 U2 1 PU AMER PSYCHIATRIC PRESS, INC PI WASHINGTON PA 1400 K ST NW, WASHINGTON, DC 20005 USA BN 978-1-58562-388-4 PY 2011 BP 305 EP 321 PG 17 WC Psychology, Clinical; Psychiatry; Psychology SC Psychology; Psychiatry GA BCF30 UT WOS:000310051000015 ER PT J AU Fauth, C Baumann, M Giunta, C Krabichler, B Ruschendorf, F Bonnemann, CG Bittner, RE Colombi, M Zoppi, N Quijano-Roy, S Romero, NB Carlier, RY Muntoni, F Cirak, S Schreiber, G Amberger, A Deutschmann, A Straub, V Rohrbach, M Rostasy, K Karall, D Zschocke, J AF Fauth, C. Baumann, M. Giunta, C. Krabichler, B. Rueschendorf, F. Boennemann, C. G. Bittner, R. E. Colombi, M. Zoppi, N. Quijano-Roy, S. Romero, N. B. Carlier, R. Y. Muntoni, F. Cirak, S. Schreiber, G. Amberger, A. Deutschmann, A. Straub, V Rohrbach, M. Rostasy, K. Karall, D. Zschocke, J. TI CONGENITAL MYOPATHY EHLERS-DANLOS OVERLAP SYNDROME CAUSED BY THE DEFICIENCY OF AN ENZYME INVOLVED IN PROTEIN FOLDING IN THE ENDOPLASMIC RETICULUM: IDENTIFICATION AND CHARACTERIZATION OF A NOVEL DISORDER SO JOURNAL OF INHERITED METABOLIC DISEASE LA English DT Meeting Abstract C1 [Fauth, C.; Krabichler, B.; Amberger, A.; Deutschmann, A.; Zschocke, J.] Innsbruck Med Univ, Div Hum Genet, Innsbruck, Austria. [Baumann, M.; Rostasy, K.; Karall, D.] Innsbruck Med Univ, Dept Paediatr 4, Innsbruck, Austria. [Giunta, C.; Rohrbach, M.] Univ Child Hosp Zurich, Div Metabol, Zurich, Switzerland. [Rueschendorf, F.] Max Delbruck Ctr Mol Med, Berlin, Germany. [Boennemann, C. G.] NINDS, NIH, Bethesda, MD 20892 USA. [Bittner, R. E.] Vienna Med Univ, Neuromusc Res Dept, Vienna, Austria. [Colombi, M.; Zoppi, N.] Univ Brescia, Div Biol Genet, Brescia, Italy. [Quijano-Roy, S.] Univ Versailles SQY, APHP, Serv Ped, Garches, France. [Romero, N. B.] Gr Hop Univ Pitie Sal, Inst Myol, Paris, France. [Carlier, R. Y.] Hop Raym Poinc, Dept Radiol, Garches, France. [Muntoni, F.; Cirak, S.] Dubowitz Neuromusc Ctr, London, England. [Schreiber, G.] Klin Kassel, Dept Neuropaed, Kassel, Germany. [Straub, V] Newcastle Univ, Inst Hum Genet, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0141-8955 J9 J INHERIT METAB DIS JI J. Inherit. Metab. Dis. PY 2011 VL 34 SU 3 BP S239 EP S239 PG 1 WC Endocrinology & Metabolism; Genetics & Heredity; Medicine, Research & Experimental SC Endocrinology & Metabolism; Genetics & Heredity; Research & Experimental Medicine GA 020TP UT WOS:000309837800556 ER PT J AU Ries, M Benko, W Wiggs, EA Brady, RO Schiffmann, R FitzGibbon, EJ AF Ries, M. Benko, W. Wiggs, E. A. Brady, R. O. Schiffmann, R. FitzGibbon, E. J. TI THE SACCADIC AND NEUROLOGICAL DEFICITS IN TYPE 3 GAUCHER DISEASE SO JOURNAL OF INHERITED METABOLIC DISEASE LA English DT Meeting Abstract C1 [Ries, M.] Ctr Pediat & Youth Med, Heidelberg, Germany. [Benko, W.; Wiggs, E. A.; Brady, R. O.] NINDS, DMNB, NIH, Bethesda, MD 20892 USA. [Schiffmann, R.] Baylor Res Inst, Dallas, TX USA. [FitzGibbon, E. J.] NEI, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0141-8955 J9 J INHERIT METAB DIS JI J. Inherit. Metab. Dis. PY 2011 VL 34 SU 3 BP S198 EP S198 PG 1 WC Endocrinology & Metabolism; Genetics & Heredity; Medicine, Research & Experimental SC Endocrinology & Metabolism; Genetics & Heredity; Research & Experimental Medicine GA 020TP UT WOS:000309837800431 ER PT J AU Ruoppolo, M Caterino, C Chandler, RJ Venditti, CP AF Ruoppolo, M. Caterino, C. Chandler, R. J. Venditti, C. P. TI DISSECTING MOLECULAR BASIS OF METHYLMALONIC ACIDEMIA (MMA) BY PROTEOMIC ANALYSIS SO JOURNAL OF INHERITED METABOLIC DISEASE LA English DT Meeting Abstract C1 [Ruoppolo, M.] Univ Naples Federico II, DBBM, Naples, Italy. [Caterino, C.] Fdn SDN, Naples, Italy. [Chandler, R. J.; Venditti, C. P.] NHGRI, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0141-8955 J9 J INHERIT METAB DIS JI J. Inherit. Metab. Dis. PY 2011 VL 34 SU 3 BP S238 EP S238 PG 1 WC Endocrinology & Metabolism; Genetics & Heredity; Medicine, Research & Experimental SC Endocrinology & Metabolism; Genetics & Heredity; Research & Experimental Medicine GA 020TP UT WOS:000309837800553 ER PT B AU Brooks, PJ AF Brooks, Philip J. BE Zakhari, S Vasiliou, V Guo, QM TI Alcohol as a Human Carcinogen SO ALCOHOL AND CANCER LA English DT Article; Book Chapter ID ESOPHAGEAL CANCER C1 NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA. RP Brooks, PJ (reprint author), NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA. EM pjbrooks@mail.nih.gov NR 8 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4614-0039-4 PY 2011 BP 1 EP 4 DI 10.1007/978-1-4614-0040-0_1 D2 10.1007/978-1-4614-0040-0 PG 4 WC Oncology; Substance Abuse SC Oncology; Substance Abuse GA BBA45 UT WOS:000306294600001 ER PT B AU Dunty, WC AF Dunty, William C., Jr. BE Zakhari, S Vasiliou, V Guo, QM TI Cancer and Alcohol: An Overview of Tumorigenesis SO ALCOHOL AND CANCER LA English DT Article; Book Chapter ID HUMAN COLORECTAL CANCERS; P53 GENE-MUTATIONS; INFLAMMATION; ONCOGENES; DELETIONS; OCCUR C1 NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA. RP Dunty, WC (reprint author), NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA. EM duntyw@mail.nih.gov NR 35 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4614-0039-4 PY 2011 BP 5 EP 18 DI 10.1007/978-1-4614-0040-0_2 D2 10.1007/978-1-4614-0040-0 PG 14 WC Oncology; Substance Abuse SC Oncology; Substance Abuse GA BBA45 UT WOS:000306294600002 ER PT B AU Gentry, RT AF Gentry, R. Thomas BE Zakhari, S Vasiliou, V Guo, QM TI Alcohol and Cancer Epidemiology SO ALCOHOL AND CANCER LA English DT Article; Book Chapter ID HEPATITIS-C INFECTION; PRIMARY LIVER-CANCER; HEPATOCELLULAR-CARCINOMA; BREAST-CANCER; RISK-FACTORS; LUNG-CANCER; COLORECTAL-CANCER; POOLED ANALYSIS; THYROID-CANCER; UNITED-STATES C1 NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA. RP Gentry, RT (reprint author), NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA. EM tgentry@niaaa.nih.gov NR 85 TC 3 Z9 3 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4614-0039-4 PY 2011 BP 19 EP 35 DI 10.1007/978-1-4614-0040-0_3 D2 10.1007/978-1-4614-0040-0 PG 17 WC Oncology; Substance Abuse SC Oncology; Substance Abuse GA BBA45 UT WOS:000306294600003 ER PT B AU Murray, GJ Brooks, PJ Zakhari, S AF Murray, Gary J. Brooks, Philip J. Zakhari, Samir BE Zakhari, S Vasiliou, V Guo, QM TI Alcohol Metabolism and Its Implications for Cancer SO ALCOHOL AND CANCER LA English DT Article; Book Chapter ID DEHYDROGENASE 1C-ASTERISK-1 ALLELE; UPPER AERODIGESTIVE TRACT; SQUAMOUS-CELL CARCINOMA; DIETARY-FOLATE INTAKE; BREAST-CANCER; ALDEHYDE DEHYDROGENASE; GENETIC POLYMORPHISMS; CLASS-I; LIPID-PEROXIDATION; OXIDATIVE STRESS C1 [Murray, Gary J.; Brooks, Philip J.; Zakhari, Samir] NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA. RP Zakhari, S (reprint author), NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA. EM szakhari@mail.nih.gov; szakhari@mail.nih.gov NR 139 TC 0 Z9 0 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4614-0039-4 PY 2011 BP 37 EP 67 DI 10.1007/978-1-4614-0040-0_4 D2 10.1007/978-1-4614-0040-0 PG 31 WC Oncology; Substance Abuse SC Oncology; Substance Abuse GA BBA45 UT WOS:000306294600004 ER PT B AU Hereld, D Guo, QM AF Hereld, Dale Guo, Q. Max BE Zakhari, S Vasiliou, V Guo, QM TI Epigenetics, Alcohol, and Cancer SO ALCOHOL AND CANCER LA English DT Article; Book Chapter ID GENOMIC DNA HYPERMETHYLATION; MESSENGER-RNA EXPRESSION; COLORECTAL-CANCER; ETHANOL EXPOSURE; HISTONE H3; IN-VIVO; HEPATOCELLULAR-CARCINOMA; METHIONINE METABOLISM; HEPATIC METHIONINE; RAT HEPATOCYTES C1 [Hereld, Dale; Guo, Q. Max] NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA. RP Hereld, D (reprint author), NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA. EM hereldd@mail.nih.gov NR 89 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4614-0039-4 PY 2011 BP 69 EP 91 DI 10.1007/978-1-4614-0040-0_5 D2 10.1007/978-1-4614-0040-0 PG 23 WC Oncology; Substance Abuse SC Oncology; Substance Abuse GA BBA45 UT WOS:000306294600005 ER PT B AU Dunty, WC AF Dunty, William C., Jr. BE Zakhari, S Vasiliou, V Guo, QM TI Alcohol, Cancer Genes, and Signaling Pathways SO ALCOHOL AND CANCER LA English DT Article; Book Chapter ID SQUAMOUS-CELL CARCINOMA; EPITHELIAL-MESENCHYMAL TRANSITION; RECEPTOR-ALPHA EXPRESSION; ENDOTHELIAL GROWTH-FACTOR; ETHANOL-INDUCED INVASION; TUMOR-SUPPRESSOR GENE; BREAST-CANCER; HEPATOCELLULAR-CARCINOMA; TGF-BETA; IN-VITRO C1 NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA. RP Dunty, WC (reprint author), NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA. EM duntyw@mail.nih.gov NR 194 TC 0 Z9 0 U1 3 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4614-0039-4 PY 2011 BP 93 EP 126 DI 10.1007/978-1-4614-0040-0_6 D2 10.1007/978-1-4614-0040-0 PG 34 WC Oncology; Substance Abuse SC Oncology; Substance Abuse GA BBA45 UT WOS:000306294600006 ER PT B AU Radaeva, S AF Radaeva, Svetlana BE Zakhari, S Vasiliou, V Guo, QM TI Alcohol, Retinoic Acid, and Cancer SO ALCOHOL AND CANCER LA English DT Article; Book Chapter ID X-RECEPTOR-ALPHA; ADENOMATOUS POLYPOSIS-COLI; VITAMIN-A STATUS; HEPATIC STELLATE CELLS; INTESTINAL MUCOSAL ALTERATIONS; MESSENGER-RNA EXPRESSION; RAT-LIVER; ALL-TRANS; BREAST-CANCER; UP-REGULATION C1 NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA. RP Radaeva, S (reprint author), NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA. EM sradaeva@mail.nih.gov NR 151 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4614-0039-4 PY 2011 BP 127 EP 153 DI 10.1007/978-1-4614-0040-0_7 D2 10.1007/978-1-4614-0040-0 PG 27 WC Oncology; Substance Abuse SC Oncology; Substance Abuse GA BBA45 UT WOS:000306294600007 ER PT B AU Orosz, A AF Orosz, Andras BE Zakhari, S Vasiliou, V Guo, QM TI Alcohol, Altered Protein Homeostasis, and Cancer SO ALCOHOL AND CANCER LA English DT Article; Book Chapter ID HEAT-SHOCK FACTOR-1; TRANSCRIPTION FACTOR HSF1; KAPPA-B ACTIVATION; FACTOR-I; DNA-BINDING; MOLECULAR CHAPERONE; GENE-EXPRESSION; NUCLEAR-FACTOR; NITRIC-OXIDE; CELL-DEATH C1 NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA. RP Orosz, A (reprint author), NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA. EM orosza@mail.nih.gov NR 76 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4614-0039-4 PY 2011 BP 155 EP 173 DI 10.1007/978-1-4614-0040-0_8 D2 10.1007/978-1-4614-0040-0 PG 19 WC Oncology; Substance Abuse SC Oncology; Substance Abuse GA BBA45 UT WOS:000306294600008 ER PT B AU Wang, HJ AF Wang, H. Joe BE Zakhari, S Vasiliou, V Guo, QM TI Alcohol and the Inflammatory Function of Immune Cells in Cancer Development SO ALCOHOL AND CANCER LA English DT Article; Book Chapter ID NF-KAPPA-B; HEPATITIS-C VIRUS; INDUCED LIVER-DISEASE; HEPATOCELLULAR-CARCINOMA; TRANSCRIPTION FACTORS; INSULIN-RESISTANCE; SUPPRESSOR-CELLS; VIRAL-HEPATITIS; TARGET GENES; EXPRESSION C1 NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA. RP Wang, HJ (reprint author), NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA. EM Wangh4@mail.nih.gov NR 83 TC 1 Z9 1 U1 1 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4614-0039-4 PY 2011 BP 175 EP 192 DI 10.1007/978-1-4614-0040-0_9 D2 10.1007/978-1-4614-0040-0 PG 18 WC Oncology; Substance Abuse SC Oncology; Substance Abuse GA BBA45 UT WOS:000306294600009 ER PT B AU Jung, MK AF Jung, M. Katherine BE Zakhari, S Vasiliou, V Guo, QM TI Immune Surveillance and Tumor Evasion SO ALCOHOL AND CANCER LA English DT Article; Book Chapter ID NATURAL-KILLER-CELLS; CHRONIC ALCOHOL-CONSUMPTION; CLASS-I PHENOTYPES; MHC CLASS-I; T-CELLS; SUPPRESSOR-CELLS; NK CELL; DENDRITIC CELLS; B16BL6 MELANOMA; CONSUMING MICE C1 NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA. RP Jung, MK (reprint author), NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA. EM jungma@mail.nih.gov NR 78 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4614-0039-4 PY 2011 BP 193 EP 210 DI 10.1007/978-1-4614-0040-0_10 D2 10.1007/978-1-4614-0040-0 PG 18 WC Oncology; Substance Abuse SC Oncology; Substance Abuse GA BBA45 UT WOS:000306294600010 ER PT B AU Gao, Z Guo, QM AF Gao, Zhigang (Peter) Guo, Q. Max BE Zakhari, S Vasiliou, V Guo, QM TI Stem Cells and Alcohol-Related Cancers SO ALCOHOL AND CANCER LA English DT Article; Book Chapter ID ACUTE MYELOID-LEUKEMIA; ALDEHYDE DEHYDROGENASE; PROGENITOR CELLS; HEPATOCELLULAR-CARCINOMA; LIVER; CARCINOGENESIS; MARKER; EXPANSION; RENEWAL; MODEL C1 [Gao, Zhigang (Peter); Guo, Q. Max] NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA. RP Guo, QM (reprint author), NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA. EM qmguo@mail.nih.gov; qmguo@mail.nih.gov NR 41 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4614-0039-4 PY 2011 BP 211 EP 223 DI 10.1007/978-1-4614-0040-0_11 D2 10.1007/978-1-4614-0040-0 PG 13 WC Oncology; Substance Abuse SC Oncology; Substance Abuse GA BBA45 UT WOS:000306294600011 ER PT B AU Zakhari, S AF Zakhari, Samir BE Zakhari, S Vasiliou, V Guo, QM TI Epilogue, Consensus Recommendations: Alcohol and Cancer SO ALCOHOL AND CANCER LA English DT Article; Book Chapter C1 NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA. RP Zakhari, S (reprint author), NIAAA, Div Metab & Hlth Effects, NIH, Bethesda, MD USA. EM szakhari@mail.nih.gov; szakhari@mail.nih.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4614-0039-4 PY 2011 BP 225 EP 232 DI 10.1007/978-1-4614-0040-0_12 D2 10.1007/978-1-4614-0040-0 PG 8 WC Oncology; Substance Abuse SC Oncology; Substance Abuse GA BBA45 UT WOS:000306294600012 ER PT J AU Jozwiak, K Plazinska, A Toll, L Jimenez, L Woo, AYH Xiao, RP Wainer, IW AF Jozwiak, Krzysztof Plazinska, Anita Toll, Lawrence Jimenez, Lucita Woo, Anthony Yiu-Ho Xiao, Rui-Ping Wainer, Irving W. TI Effect of Fenoterol Stereochemistry on the beta 2 Adrenergic Receptor System: Ligand-Directed Chiral Recognition SO CHIRALITY LA English DT Article; Proceedings Paper CT 22nd International Symposium on Chirality CY 2010 CL Sapporo, JAPAN DE G protein-coupled receptors; beta(2) adrenergic agonists; stereoselective binding; affinity; efficacy; Van't Hoff analysis ID PROTEIN-COUPLED RECEPTOR; MOLECULAR-FIELD ANALYSIS; BETA(2)-ADRENERGIC RECEPTOR; STEREOISOMERS; AGONISTS; BINDING; ADRENOCEPTOR; DERIVATIVES; ACTIVATION; SEPARATION AB The beta(2) adrenergic receptor (beta(2)-AR) is a model system for studying the ligand recognition process in G protein-coupled receptors. Fenoterol (FEN) is a beta(2)-AR selective agonist that has two centers of chirality and exists as four stereoisomers. Radioligand binding studies determined that stereochemistry greatly influences the binding affinity. Subsequent Van't Hoff analysis shows very different thermodynamics of binding depending on the stereoconfiguration of the molecule. The binding of (S, x')-isomers is almost entirely enthalpy controlled whereas binding of (R, x')-isomers is purely entropy driven. Stereochemistry of FEN molecule also affects the coupling of the receptor to different G proteins. In a rat cardiomyocyte contractility model, (R, R')-FEN was shown to selectively activate Gs protein signaling while the (S, R')-isomer activated both G(i) and G(s) protein. The overall data demonstrate that the chirality at the two chiral centers of the FEN molecule influences the magnitude of binding affinity, thermodynamics of local interactions within the binding site, and the global mechanism of beta(2)-AR activation. Differences in thermodynamic parameters and nonuniform G-protein coupling suggest a mechanism of chiral recognition in which observed enantioselectivities arise from the interaction of the (R, x')-FEN stereoisomers with a different receptor conformation than the one with which the (S, x')-isomer interacts. Chirality 23: E1-E6, 2011. (C) 2011 Wiley Periodicals, Inc. C1 [Jozwiak, Krzysztof; Plazinska, Anita] Med Univ Lublin, Lab Med Chem & Neuroengn, PL-20093 Lublin, Poland. [Toll, Lawrence; Jimenez, Lucita] SRI Int, Neuropharmacol Program, Menlo Pk, CA 94025 USA. [Woo, Anthony Yiu-Ho; Xiao, Rui-Ping; Wainer, Irving W.] NIA, Clin Invest Lab, Baltimore, MD 21224 USA. RP Jozwiak, K (reprint author), Med Univ Lublin, Lab Med Chem & Neuroengenering, Ul Chodzki 4A, PL-20093 Lublin, Poland. EM krzysztof.jozwiak@umlub.pl RI Woo, Anthony/D-4305-2014 OI Woo, Anthony/0000-0003-0662-698X FU Intramural NIH HHS [ZIA AG000297-09]; NIDA NIH HHS [HHSN271201000001I, HHSN271201000001W]; PHS HHS [HHSN2712010000081] NR 21 TC 10 Z9 10 U1 0 U2 17 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0899-0042 J9 CHIRALITY JI Chirality PY 2011 VL 23 IS 1E SI SI BP E1 EP E6 DI 10.1002/chir.20963 PG 6 WC Chemistry, Medicinal; Chemistry, Analytical; Chemistry, Organic; Pharmacology & Pharmacy SC Pharmacology & Pharmacy; Chemistry GA 010DG UT WOS:000309074200001 PM 21618615 ER PT B AU Tatusova, T AF Tatusova, Tatiana BE Pellegrini, M Fred, A Filipe, J Gamboa, H TI INFRASTRUCTURE FOR METAGENOME DATA MANAGEMENT AND ANALYSIS SO BIOINFORMATICS 2011 LA English DT Proceedings Paper CT International Conferene on Bioinformatics Models, Methods and Algorithms CY JAN 26-29, 2011 CL Rome, ITALY SP Inst Syst & Technol Informat, Control & Commun, IEEE, Engn Med & Biol Soc, IEEE, Portugal EMBS Chapter, ESEM, BMES DE Database; Sequence analysis; Metagenomics ID BLAST; SEQUENCES AB Metagenome sequencing projects are generating unprecedented amounts of data. Public sequence archive databases are challenged with large-scale data management issues including data storage, quick search and retrieval of the sequence data for further analysis. The sequence data is linked to the rich set of metadata attributes such as geochemical and ecological parameters for environmental projects and clinical patient information for human microbiome studies. That complex collection of heterogeneous information has to be integrated, organized and presented to the users in a meaningful and the most useful way. For the last 20 years The National Center for Biotechnology Information (NCBI) has been developing the infrastructure that allows an easy storage and distribution of various types of bimolecular data as well as data integration and easy navigation in complex information space. Here we describe NCBI resources that are used for metagenomics data management. C1 NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20892 USA. RP Tatusova, T (reprint author), NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, 9600 Rockville Pike, Bethesda, MD 20892 USA. NR 9 TC 0 Z9 0 U1 0 U2 2 PU SCITEPRESS PI SETUBAL PA AV D MANUELL, 27A 2 ESQ, SETUBAL, 2910-595, PORTUGAL BN 978-989-8425-36-2 PY 2011 BP 357 EP 362 PG 6 WC Medical Informatics SC Medical Informatics GA BBW54 UT WOS:000308455800059 ER PT J AU Kristensen, DM Mushegian, AR Koonin, EV AF Kristensen, David M. Mushegian, Arcady R. Koonin, Eugene V. TI Systems biology of bacteriophage proteins and new dimensions of the virus world discovered through metagenomics SO GENOME BIOLOGY LA English DT Meeting Abstract C1 [Kristensen, David M.; Koonin, Eugene V.] NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20894 USA. [Mushegian, Arcady R.] Stowers Inst Med Res, Dept Bioinformat, Kansas City, MO 64110 USA. [Mushegian, Arcady R.] Univ Kansas, Med Ctr, Dept Microbiol Mol Genet & Immunol, Kansas City, KS 66160 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1474-7596 J9 GENOME BIOL JI Genome Biol. PY 2011 VL 12 SU 1 MA P9 BP 9 EP 9 PG 1 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA 002QH UT WOS:000308546700024 ER PT J AU Rope, AF Wang, K Evjenth, R Xing, JC Johnston, JJ Swensen, JJ Johnson, WE Moore, B Huff, CD Bird, LM Carey, JC Opitz, JM Stevens, CA Schank, C Fain, HD Robison, R Dalley, B Chin, S South, ST Pysher, TJ Jorde, LB Hakonarson, H Lillehaug, JR Biesecker, LG Yandell, M Arnesen, T Lyon, GJ AF Rope, Alan F. Wang, Kai Evjenth, Rune Xing, Jinchuan Johnston, Jennifer J. Swensen, Jeffrey J. Johnson, W. Evan Moore, Barry Huff, Chad D. Bird, Lynne M. Carey, John C. Opitz, John M. Stevens, Cathy A. Schank, Christa Fain, Heidi Deborah Robison, Reid Dalley, Brian Chin, Steven South, Sarah T. Pysher, Theodore J. Jorde, Lynn B. Hakonarson, Hakon Lillehaug, Johan R. Biesecker, Leslie G. Yandell, Mark Arnesen, Thomas Lyon, Gholson J. TI Massively parallel sequencing identifies a previously unrecognized X-linked disorder resulting in lethality in male infants owing to amino-terminal acetyltransferase deficiency SO GENOME BIOLOGY LA English DT Meeting Abstract C1 [Rope, Alan F.; Carey, John C.; Opitz, John M.; South, Sarah T.] Univ Utah, Sch Med, Dept Pediat Med Genet, Salt Lake City, UT USA. [Wang, Kai; Hakonarson, Hakon] Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA. [Evjenth, Rune; Lillehaug, Johan R.; Arnesen, Thomas] Univ Bergen, Dept Mol Biol, N-5020 Bergen, Norway. [Xing, Jinchuan; Moore, Barry; Huff, Chad D.; Opitz, John M.; Jorde, Lynn B.; Yandell, Mark] Univ Utah, Eccles Inst Human Genet, Salt Lake City, UT USA. [Johnston, Jennifer J.; Biesecker, Leslie G.] NHGRI, Genet Dis Res Branch, NIH, Bethesda, MD 20892 USA. [Swensen, Jeffrey J.; Opitz, John M.; Chin, Steven; Pysher, Theodore J.] Univ Utah, Dept Pathol, Salt Lake City, UT USA. [Swensen, Jeffrey J.; South, Sarah T.] ARUP Labs, Salt Lake City, UT USA. [Johnson, W. Evan; Schank, Christa] Brigham Young Univ, Dept Stat, Provo, UT 84602 USA. [Bird, Lynne M.] Rady Childrens Hosp, San Diego, CA USA. [Bird, Lynne M.] Univ Calif San Diego, Dept Pediat, San Diego, CA 92103 USA. [Opitz, John M.] Univ Utah, Dept Obstet & Gynecol, Salt Lake City, UT 84132 USA. [Stevens, Cathy A.] Univ Tennessee, Dept Pediat, Coll Med, Chattanooga, TN USA. [Fain, Heidi Deborah; Robison, Reid; Lyon, Gholson J.] Univ Utah, Dept Psychiat, Salt Lake City, UT USA. [Dalley, Brian] Huntsman Canc Inst, Salt Lake City, UT USA. [Arnesen, Thomas] Haukeland Hosp, Dept Surg, N-5021 Bergen, Norway. [Lyon, Gholson J.] NYU, Ctr Child Study, New York, NY USA. RI Lyon, Gholson/D-2765-2014 OI Lyon, Gholson/0000-0002-5869-0716 NR 0 TC 0 Z9 0 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1474-7596 J9 GENOME BIOL JI Genome Biol. PY 2011 VL 12 SU 1 MA P13 BP 11 EP 11 PG 1 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA 002QH UT WOS:000308546700027 ER PT J AU Tang, W Fu, YP Figueroa, JD Malats, N Garcia-Closas, M Chatterjee, N Kogevinas, M Baris, D Thun, M Hall, JL De Vivo, I Albanes, D Porter-Gill, P Purdue, MP Burdett, L Liu, LY Hutchinson, A Myers, T Tardon, A Serra, C Carrato, A Garcia-Closas, R Lloreta, J Johnson, A Schwenn, M Karagas, MR Schned, A Black, A Jacobs, EJ Diver, R Gapstur, SM Virtamo, J Hunter, DJ Fraumeni, JF Chanock, SJ Silverman, DT Rothman, N Prokunina-Olsson, L AF Tang, Wei Fu, Yi-Ping Figueroa, Jonine D. Malats, Nuria Garcia-Closas, Montserrat Chatterjee, Nilanjan Kogevinas, Manolis Baris, Dalsu Thun, Michael Hall, Jennifer L. De Vivo, Immaculata Albanes, Demetrius Porter-Gill, Patricia Purdue, Mark P. Burdett, Laurie Liu, Luyang Hutchinson, Amy Myers, Timothy Tardon, Adonina Serra, Consol Carrato, Alfredo Garcia-Closas, Reina Lloreta, Josep Johnson, Alison Schwenn, Molly Karagas, Margaret R. Schned, Alan Black, Amanda Jacobs, Eric J. Diver, Ryan Gapstur, Susan M. Virtamo, Jarmo Hunter, David J. Fraumeni, Joseph F., Jr. Chanock, Stephen J. Silverman, Debra T. Rothman, Nathaniel Prokunina-Olsson, Ludmila TI An unusual suspect: an uncommon human-specific synonymous coding variant within the UGT1A6 gene explains a GWAS signal and protects against bladder cancer SO GENOME BIOLOGY LA English DT Meeting Abstract C1 [Tang, Wei; Fu, Yi-Ping; Porter-Gill, Patricia; Liu, Luyang; Chanock, Stephen J.; Prokunina-Olsson, Ludmila] NCI, Lab Translat Genom, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. [Malats, Nuria] Spanish Natl Canc Res Ctr, Madrid 28029, Spain. [Garcia-Closas, Montserrat] Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England. [Kogevinas, Manolis] Ctr Res Environm Epidemiol CREAL, Barcelona 08003, Spain. [Kogevinas, Manolis] Municipal Inst Med Res, Barcelona 08003, Spain. [Kogevinas, Manolis] CIBER Epidemiol Salud Publ CIBERESP, Barcelona 08003, Spain. [Kogevinas, Manolis] Natl Sch Publ Hlth, Athens 11521, Greece. [Thun, Michael; Jacobs, Eric J.; Diver, Ryan; Gapstur, Susan M.] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30303 USA. [Hall, Jennifer L.] Univ Minnesota, Lillehei Heart Inst, Dept Med, Minneapolis, MN 55455 USA. [De Vivo, Immaculata] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA 02115 USA. [Burdett, Laurie; Hutchinson, Amy; Myers, Timothy] NCI, Core Genotype Facil, SAIC Frederick, Frederick, MD 21702 USA. [Tardon, Adonina] Univ Oviedo, Oviedo 33003, Spain. [Serra, Consol] Univ Pompeu Fabra, Barcelona 08002, Spain. [Carrato, Alfredo] Ramon & Cajal Univ Hosp, Madrid 28034, Spain. [Garcia-Closas, Reina] Hosp Univ Canarias, Unidad Invest, San Cristobal la Laguna 38320, Spain. [Lloreta, Josep] Univ Pompeu Fabra, Hosp del Mar, Inst Municipal Invest Med IMIM, Barcelona 08003, Spain. [Johnson, Alison] Vermont Canc Registry, Burlington, VT 05401 USA. [Schwenn, Molly] Maine Canc Registry, Augusta, ME 04333 USA. [Karagas, Margaret R.] Dartmouth Med Sch, Hanover, NH 03755 USA. [Schned, Alan] Washington Univ, Sch Med, Dept Urol, St Louis, MO 63110 USA. [Virtamo, Jarmo] Natl Inst Hlth & Welf, Helsinki 00271, Finland. [Hunter, David J.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Program Mol & Genet Epidemiol, Boston, MA 02115 USA. RI Serra, C/E-6879-2014; Lloreta, J/I-2112-2014; Albanes, Demetrius/B-9749-2015; Garcia-Closas, Montserrat /F-3871-2015; Malats, Nuria/H-7041-2015; Purdue, Mark/C-9228-2016; Kogevinas, Manolis/C-3918-2017 OI Serra, C/0000-0001-8337-8356; Lloreta, J/0000-0003-1644-9470; Garcia-Closas, Montserrat /0000-0003-1033-2650; Malats, Nuria/0000-0003-2538-3784; Purdue, Mark/0000-0003-1177-3108; NR 0 TC 0 Z9 0 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1474-7596 J9 GENOME BIOL JI Genome Biol. PY 2011 VL 12 SU 1 MA P19 BP 13 EP 13 PG 1 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA 002QH UT WOS:000308546700032 ER PT J AU Cer, RZ Bruce, KH Donohue, DE Temiz, AN Bacolla, A Mudunuri, US Yi, M Volfovsky, N Luke, BT Collins, JR Stephens, RM AF Cer, Regina Z. Bruce, Kevin H. Donohue, Duncan E. Temiz, Alpay N. Bacolla, Albino Mudunuri, Uma S. Yi, Ming Volfovsky, Natalia Luke, Brian T. Collins, Jack R. Stephens, Robert M. TI Introducing the non-B DNA Motif Search Tool (nBMST) SO GENOME BIOLOGY LA English DT Meeting Abstract C1 [Cer, Regina Z.; Bruce, Kevin H.; Donohue, Duncan E.; Temiz, Alpay N.; Bacolla, Albino; Mudunuri, Uma S.; Luke, Brian T.; Collins, Jack R.; Stephens, Robert M.] NCI, Adv Biomed Comp Ctr, Informat Syst Program, SAIC Frederick, Frederick, MD 21702 USA. [Bacolla, Albino] Univ Texas Austin, Dell Pediat Res Inst, Dept Pharm, Austin, TX 78723 USA. RI Bacolla, Albino/N-3877-2013 OI Bacolla, Albino/0000-0003-0206-8423 NR 2 TC 0 Z9 0 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1474-7596 J9 GENOME BIOL JI Genome Biol. PY 2011 VL 12 SU 1 MA P34 BP 20 EP 20 PG 1 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA 002QH UT WOS:000308546700047 ER PT J AU Kitanaka, N Kitanaka, J Watabe, K Hall, FS Uhl, GR Tanaka, K Nishiyama, N Takemura, M AF Kitanaka, Nobue Kitanaka, Junichi Watabe, Kaname Hall, F. Scott Uhl, George R. Tanaka, Koh-ichi Nishiyama, Nobuyoshi Takemura, Motohiko TI Acute administration of methamphetamine decreases running wheel activity in mice SO NEUROSCIENCE RESEARCH LA English DT Meeting Abstract C1 [Kitanaka, Nobue; Kitanaka, Junichi; Takemura, Motohiko] Hyogo Coll Med, Dept Pharmacol, Nishinomiya, Hyogo 6638501, Japan. [Watabe, Kaname] Muromachi Kikai Co Ltd, Tech Dept, Tokyo, Japan. [Hall, F. Scott; Uhl, George R.] NIDA, IRP, NIH, DHHS, Baltimore, MD USA. [Tanaka, Koh-ichi; Nishiyama, Nobuyoshi] Hyogo Univ Hlth Sci, Sch Pharm, Dept Pharm, Div Pharmacol, Kobe, Hyogo, Japan. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0168-0102 J9 NEUROSCI RES JI Neurosci. Res. PY 2011 VL 71 SU S BP E396 EP E396 DI 10.1016/j.neures.2011.07.1738 PG 1 WC Neurosciences SC Neurosciences & Neurology GA 998DT UT WOS:000308218102209 ER PT J AU Santos, GS Gireesh, ED Yu, S Plenz, D Nakahara, H AF Santos, Gustavo S. Gireesh, Elakkat D. Yu, Shan Plenz, Dietmar Nakahara, Hiroyuki TI The hierarchical model captures higher-order interactions in cortical activity SO NEUROSCIENCE RESEARCH LA English DT Meeting Abstract C1 [Santos, Gustavo S.; Nakahara, Hiroyuki] RIKEN Brain Sci Inst, Lab Integrated Theor Neurosci, Wako, Saitama, Japan. [Gireesh, Elakkat D.] New York U, Dept Neurol, New York, NY USA. [Yu, Shan; Plenz, Dietmar] NIMH, Sect Crit Brain Dynam, Lab Sys Neurosci, Bethesda, MD 20892 USA. [Nakahara, Hiroyuki] Tokyo Inst Tech, Dept Comp Intel & Sys Sci, Yokohama, Kanagawa, Japan. RI Nakahara, Hiroyuki/N-5411-2015 OI Nakahara, Hiroyuki/0000-0001-6891-1175 NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0168-0102 J9 NEUROSCI RES JI Neurosci. Res. PY 2011 VL 71 SU S BP E307 EP E307 DI 10.1016/j.neures.2011.07.1337 PG 1 WC Neurosciences SC Neurosciences & Neurology GA 998DT UT WOS:000308218101580 ER PT J AU Suzuki, N Hirasawa, E Yamada, Y Akazawa, C AF Suzuki, Nobuharu Hirasawa, Eri Yamada, Yoshihiko Akazawa, Chihiro TI Oligodendrocyte development and dysmyelinating diseases: Teneurin-4 as a novel regulator of CNS myelination SO NEUROSCIENCE RESEARCH LA English DT Meeting Abstract C1 [Suzuki, Nobuharu; Akazawa, Chihiro] Tokyo Med Dent Univ, Grad Sch Healthcare Sci, Dep Biochem & Biophys, Tokyo, Japan. [Suzuki, Nobuharu; Yamada, Yoshihiko] NIDCR, NIH, Bethesda, MD USA. [Hirasawa, Eri] Juntendo Univ, Res Inst Disea Old Age, Tokyo, Japan. [Hirasawa, Eri] Juntendo Univ, Facul Med, Dep Neurol, Tokyo, Japan. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0168-0102 J9 NEUROSCI RES JI Neurosci. Res. PY 2011 VL 71 SU S BP E25 EP E26 DI 10.1016/j.neures.2011.07.108 PG 2 WC Neurosciences SC Neurosciences & Neurology GA 998DT UT WOS:000308218100105 ER PT J AU Klee, MM AF Klee, Maurice M. TI The Case of the Unanswered Question SO IEEE PULSE LA English DT Editorial Material C1 [Klee, Maurice M.] NIH, Bethesda, MD 20892 USA. [Klee, Maurice M.] Michigan State Univ, Coll Engn, E Lansing, MI 48824 USA. EM mk@maurieklee.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 2154-2287 J9 IEEE PULSE JI IEEE Pulse PD JAN-FEB PY 2011 VL 2 IS 1 BP 49 EP 49 DI 10.1109/MPUL.2010.939612 PG 1 WC Engineering, Biomedical SC Engineering GA 992DG UT WOS:000307755200016 ER PT S AU Filipovych, R Resnick, SM Davatzikos, C AF Filipovych, Roman Resnick, Susan M. Davatzikos, Christos BE Suzuki, K Wang, F Shen, DG Yan, PK TI Multi-Kernel Classification for Integration of Clinical and Imaging Data: Application to Prediction of Cognitive Decline in Older Adults SO MACHINE LEARNING IN MEDICAL IMAGING SE Lecture Notes in Computer Science LA English DT Proceedings Paper CT 2nd International Workshop on Machine Learning in Medical Imaging (MLMI 2011) CY SEP 18, 2011 CL Toronto, CANADA DE Multi-Kernel Learning (MKL); Normal aging; MRI ID ATROPHY; BRAIN AB Diagnosis of neurologic and neuropsychiatric disorders typically involves considerable assessment including clinical observation, neuroimaging, and biological and neuropsychological measurements. While it is reasonable to expect that the integration of neuroimaging data and complementary non-imaging measures is likely to improve early diagnosis on individual basis, due to technical challenges associated with the task of combining different data types, medical image pattern recognition analysis has been largely focusing solely on neuroimaging evaluations. In this paper, we explore the potential of integrating neuroimaging and clinical information within a pattern classification framework, and propose that the multi-kernel learning (MKL) paradigm may be suitable for building a multimodal classifier of a disorder, as well as for automatic identification of the relevance of each information type. We apply our approach to the problem of detecting cognitive decline in healthy older adults from single-visit evaluations, and show that the performance of a classifier can be improved when nouroimaging and clinical evaluations are used simultaneously within a MKL-based classification framework. C1 [Filipovych, Roman; Davatzikos, Christos] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA. [Resnick, Susan M.] Biomed Res Ctr, Lab Personal Cognit, Baltimore, MD 21224 USA. RP Filipovych, R (reprint author), Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA. FU Intramural Research Program of the NIH; National Institute on Aging (NIA) [R01-AG14971, N01-AG-3-2124] FX This research was supported in part by the Intramural Research Program of the NIH, National Institute on Aging (NIA), and R01-AG14971, N01-AG-3-2124, N01-AG-3-2124. NR 20 TC 4 Z9 4 U1 0 U2 1 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0302-9743 BN 978-3-642-24318-9 J9 LECT NOTES COMPUT SC PY 2011 VL 7009 BP 26 EP + PG 3 WC Computer Science, Artificial Intelligence; Computer Science, Theory & Methods; Radiology, Nuclear Medicine & Medical Imaging SC Computer Science; Radiology, Nuclear Medicine & Medical Imaging GA BBA61 UT WOS:000306302100004 ER PT S AU Bagci, U Yao, JH Caban, J Suffredini, AF Palmore, TN Mollura, DJ AF Bagci, Ulas Yao, Jianhua Caban, Jesus Suffredini, Anthony F. Palmore, Tara N. Mollura, Daniel J. BE Fichtinger, G Martel, A Peters, T TI Learning Shape and Texture Characteristics of CT Tree-in-Bud Opacities for CAD Systems SO MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION, MICCAI 2011, PT III SE Lecture Notes in Computer Science LA English DT Proceedings Paper CT 14th International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI 2011) CY SEP 18-22, 2011 CL Toronto, CANADA DE Tree-in-Bud; Willmore Energy; Lung; Infectious Diseases; Computer Assisted Detection ID SEGMENTATION AB Although radiologists can employ CAD systems to characterize malignancies, pulmonary fibrosis and other chronic diseases; the design of imaging techniques to quantify infectious diseases continue to lag behind. There exists a need to create more CAD systems capable of detecting and quantifying characteristic patterns often seen in respiratory tract infections such as influenza, bacterial pneumonia, or tuborculosis. One of such patterns is Tree-in-bud (TIB) which presents thickened bronchial structures surrounding by clusters of micro-nodules. Automatic detection of TIB patterns is a challenging task because of their weak boundary, noisy appearance, and small lesion size. In this paper, we present two novel methods for automatically detecting TIB patterns: (1) a fast localization of candidate patterns using information from local scale of the images, and (2) a Mobius invariant feature extraction method based on learned local shape and texture properties. A comparative evaluation of the proposed methods is presented with a dataset of 39 laboratory confirmed viral bronchiolitis human parainfluenza (HPIV) CTs and 21 normal lung CTs. Experimental results demonstrate that the proposed CAD system can achieve high detection rate with an overall accuracy of 90.96%. C1 [Bagci, Ulas; Yao, Jianhua; Mollura, Daniel J.] NIH, Dept Radiol & Imaging Sci, Bldg 10, Bethesda, MD 20892 USA. [Caban, Jesus] NIH, Natl Lib Med, Bethesda, MD 20892 USA. [Suffredini, Anthony F.] NIH, Dept Crit Care Med, Bethesda, MD 20892 USA. [Palmore, Tara N.] NIH, Lab Clin Infect Dis, Bethesda, MD 20892 USA. RP Bagci, U (reprint author), NIH, Dept Radiol & Imaging Sci, Bldg 10, Bethesda, MD 20892 USA. EM ulas.bagci@nih.gov OI Bagci, Ulas/0000-0001-7379-6829 NR 7 TC 3 Z9 3 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0302-9743 BN 978-3-642-23625-9; 978-3-642-23626-6 J9 LECT NOTES COMPUT SC PY 2011 VL 6893 BP 215 EP + PN III PG 2 WC Computer Science, Theory & Methods; Radiology, Nuclear Medicine & Medical Imaging SC Computer Science; Radiology, Nuclear Medicine & Medical Imaging GA BBI77 UT WOS:000306990200027 ER PT S AU Cao, YH Yuan, Y Li, XL Turkbey, B Choyke, PL Yan, PK AF Cao, Yihui Yuan, Yuan Li, Xuelong Turkbey, Baris Choyke, Peter L. Yan, Pingkun BE Fichtinger, G Martel, A Peters, T TI Segmenting Images by Combining Selected Atlases on Manifold SO MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION, MICCAI 2011, PT III SE Lecture Notes in Computer Science LA English DT Proceedings Paper CT 14th International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI 2011) CY SEP 18-22, 2011 CL Toronto, CANADA ID SEGMENTATION; STRATEGIES AB Atlas selection and combination are two critical factors affecting the performance of atlas-based segmentation methods. In the existing works, those tasks are completed in the original image space. However, the intrinsic similarity between the images may not be accurately reflected by the Euclidean distance in this high-dimensional space. Thus, the selected atlases may be away from the input image and the generated template by combining those atlases for segmentation can be misleading. In this paper, we propose to select and combine atlases by projecting the images onto a low-dimensional manifold. With this approach, atlases can be selected according to their intrinsic similarity to the patient image. A novel method is also proposed to compute the weights for more efficiently combining the selected atlases to achieve better segmentation performance. The experimental results demonstrated that our proposed method is robust and accurate, especially when the number of training samples becomes large. C1 [Cao, Yihui; Yuan, Yuan; Li, Xuelong; Yan, Pingkun] Chinese Acad Sci, Xian Inst Opt & Precis Mech, State Key Lab Transient Opt & Photon, Ctr OPT IMagery Anal & Learning OPTIMAL, Xian 710119, Shaanxi, Peoples R China. [Turkbey, Baris; Choyke, Peter L.] NIH, Natl Canc Inst, Mol Imaging Program, Bethesda, MD 20892 USA. RP Cao, YH (reprint author), Chinese Acad Sci, Xian Inst Opt & Precis Mech, State Key Lab Transient Opt & Photon, Ctr OPT IMagery Anal & Learning OPTIMAL, Xian 710119, Shaanxi, Peoples R China. FU National Basic Research Program of China [2011CB707000]; National Natural Science Foundation of China [61072093] FX The presented research work is supported by the National Basic Research Program of China (973 Program) (Grant No. 2011CB707000) and the National Natural Science Foundation of China (Grant No. 61072093). NR 9 TC 25 Z9 25 U1 0 U2 1 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0302-9743 BN 978-3-642-23625-9; 978-3-642-23626-6 J9 LECT NOTES COMPUT SC PY 2011 VL 6893 BP 272 EP + PN III PG 2 WC Computer Science, Theory & Methods; Radiology, Nuclear Medicine & Medical Imaging SC Computer Science; Radiology, Nuclear Medicine & Medical Imaging GA BBI77 UT WOS:000306990200034 ER PT S AU Lu, XG Jolly, MP Georgescu, B Hayes, C Speier, P Schmidt, M Bi, XM Kroeker, R Comaniciu, D Kellman, P Mueller, E Guehring, J AF Lu, Xiaoguang Jolly, Marie-Pierre Georgescu, Bogdan Hayes, Carmel Speier, Peter Schmidt, Michaela Bi, Xiaoming Kroeker, Randall Comaniciu, Dorin Kellman, Peter Mueller, Edgar Guehring, Jens BE Fichtinger, G Martel, A Peters, T TI Automatic View Planning for Cardiac MRI Acquisition SO MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION, MICCAI 2011, PT III SE Lecture Notes in Computer Science LA English DT Proceedings Paper CT 14th International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI 2011) CY SEP 18-22, 2011 CL Toronto, CANADA ID IMAGES; MODELS AB Conventional cardiac MRI acquisition involves a multi-step approach, requiring a few double-oblique localizers in order to locate the heart and prescribe long- and short-axis views of the heart. This approach is operator-dependent and time-consuming. We propose a new approach to automating and accelerating the acquisition process to improve the clinical workflow. We capture a highly accelerated static 3D full-chest volume through parallel imaging within one breath-hold. The left ventricle is localized and segmented, including left ventricle outflow tract. A number of cardiac landmarks are then detected to anchor the cardiac chambers and calculate standard 2-, 3-, and 4-chamber long-axis views along with a short-axis stack. Learning-based algorithms are applied to anatomy segmentation and anchor detection. The proposed algorithm is evaluated on 173 localizer acquisitions. The entire view planning is fully automatic and takes less than 10 seconds in our experiments. C1 [Lu, Xiaoguang; Jolly, Marie-Pierre; Georgescu, Bogdan; Comaniciu, Dorin] Siemens Corp Res, Image Analyt & Informat, Princeton, NJ USA. [Hayes, Carmel; Speier, Peter; Schmidt, Michaela; Mueller, Edgar; Guehring, Jens] Siemens AG, Healthcare Sect, Erlangen, Germany. [Bi, Xiaoming] Siemens Med Solut USA, Chicago, IL USA. [Kroeker, Randall] Siemens Med Solut Canada, Winnipeg, MB, Canada. [Kellman, Peter] Natl Inst Hlth, Bethesda, MD USA. RP Lu, XG (reprint author), Siemens Corp Res, Image Analyt & Informat, Princeton, NJ USA. EM xiaoguang.lu@siemens.com NR 12 TC 4 Z9 4 U1 0 U2 2 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0302-9743 BN 978-3-642-23625-9; 978-3-642-23626-6 J9 LECT NOTES COMPUT SC PY 2011 VL 6893 BP 479 EP + PN III PG 2 WC Computer Science, Theory & Methods; Radiology, Nuclear Medicine & Medical Imaging SC Computer Science; Radiology, Nuclear Medicine & Medical Imaging GA BBI77 UT WOS:000306990200059 ER PT S AU Cohen, T Widdows, D Schvaneveldt, R Rindflesch, TC AF Cohen, Trevor Widdows, Dominic Schvaneveldt, Roger Rindflesch, Thomas C. BE Song, D Melucci, M Frommholz, I Zhang, P Wang, L Arafat, S TI Finding Schizophrenia's Prozac Emergent Relational Similarity in Predication Space SO QUANTUM INTERACTION SE Lecture Notes in Computer Science LA English DT Proceedings Paper CT 5th International Symposium on Quantum Interaction CY JUN 26-29, 2011 CL Aberdeen, SCOTLAND SP Scottish Informat & Comp Sci Alliance DE Distributional Semantics; Vector Symbolic Architectures; Literature-based Discovery; Abductive Reasoning ID LITERATURE-BASED DISCOVERY; REPRESENTATION; KNOWLEDGE; ANALOGY; SYSTEM AB In this paper, we investigate the ability of the Predication-based Semantic Indexing (PSI) approach, which incorporates both symbolic and distributional information, to support inference on the basis of structural similarity. For example, given a pair of related concepts prozac:depression, we attempt to identify concepts that relate to a third concept, such as schizophrenia in the same way. A novel PSI implementation based on Kanerva's Binary Spatter Code is developed, and evaluated on over 100,000 searches across 180,285 unique concepts and multiple typed relations. PSI is shown to retrieve with accuracy concepts on the basis of shared single and paired relations, given either a single strong example pair, or the superposition of a set of weaker examples. Search space size is identical for single and double relations, providing an efficient means to direct search across predicate paths for the purpose of literature-based discovery. C1 [Cohen, Trevor] Univ Texas Hlth Sci Ctr Houston, Houston, TX 77225 USA. [Widdows, Dominic] Google Inc, Santa Clara, CA USA. [Schvaneveldt, Roger] Arizona State Univ, Tempe, AZ USA. [Rindflesch, Thomas C.] Natl Lib Med, Bethesda, MD USA. RP Cohen, T (reprint author), Univ Texas Hlth Sci Ctr Houston, Houston, TX 77225 USA. FU US National Library of Medicine [R21LM010826-01]; Google Inc. FX This research was supported in part by the US National Library of Medicine grant (R21LM010826-01). The authors would also like to acknowledge Google Inc. for their support of author DWs ongoing research on the subject. NR 30 TC 4 Z9 4 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0302-9743 BN 978-3-642-24970-9 J9 LECT NOTES COMPUT SC PY 2011 VL 7052 BP 48 EP + PG 3 WC Computer Science, Interdisciplinary Applications; Computer Science, Theory & Methods; Physics, Multidisciplinary SC Computer Science; Physics GA BBI79 UT WOS:000306990400006 ER PT J AU Wake, H Fields, RD AF Wake, Hiroaki Fields, R. Douglas TI Physiological function of microglia SO NEURON GLIA BIOLOGY LA English DT Article DE Microglia; neurogenesis; synaptic plasticity; Rett syndrome; autism; chronic pain ID IN-VIVO; CELLS; TERMINALS; SYNAPSES AB Broad interest in the rapidly advancing field of microglial involvement in forming neural circuits is evident from the fresh findings published in leading journals. This special issue of Neuron Glia Biology contains a special collection of research articles and reviews concerning the new appreciation of microglial function in the normal physiology of the brain that extends beyond their traditionally understood role in pathology. C1 [Wake, Hiroaki; Fields, R. Douglas] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Nervous Syst Dev & Plast Sect, Bethesda, MD 20892 USA. RP Wake, H (reprint author), Natl Inst Nat Sci, Natl Inst Basic Biol, Div Brain Circuits, Room 384,Nishigonaka 38, Okazaki, Aichi 4448585, Japan. EM hirowake@nibb.ac.jp FU Intramural NIH HHS [ZIA HD000713-15] NR 20 TC 0 Z9 1 U1 1 U2 7 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1740-925X J9 NEURON GLIA BIOL JI Neuron Glia Biol. PY 2011 VL 7 IS 1 SI SI BP 1 EP 3 DI 10.1017/S1740925X12000166 PG 3 WC Neurosciences SC Neurosciences & Neurology GA 984FH UT WOS:000307175000001 PM 22857736 ER PT J AU Wong, WT Wang, MH Li, W AF Wong, Wai T. Wang, Minhua Li, Wei TI Regulation of microglia by ionotropic glutamatergic and GABAergic neurotransmission SO NEURON GLIA BIOLOGY LA English DT Article DE Microglial motility; purinergic transmission; ATP; pannexin channels; neuronal activity ID ATP RELEASE; IN-VIVO; PANNEXIN-1 CHANNELS; ALZHEIMERS-DISEASE; CULTURED MICROGLIA; RETINAL MICROGLIA; RESTING MICROGLIA; EXTRACELLULAR ATP; P2Y RECEPTORS; MOUSE RETINA AB Recent studies have indicated that constitutive functions of microglia in the healthy adult central nervous system (CNS) involve immune surveillance, synapse maintenance and trophic support. These functions have been related to the ramified structure of 'resting' microglia and the prominent motility in their processes that provide extensive coverage of the entire extracellular milleu. In this review, we examine how external signals, and in particular, ionotropic neurotransmission, regulate features of microglial morphology and process motility. Current findings indicate that microglial physiology in the healthy CNS is constitutively and reciprocally regulated by endogenous ionotropic glutamatergic and GABAergic neurotransmission. These influences do not act directly on microglial cells but indirectly via the activity-dependent release of ATP, likely through a mechanism involving pannexin channels. Microglia in the 'resting' state are not only dynamically active, but also constantly engaged in ongoing communication with neuronal and macroglial components of the CNS in a functionally relevant way. C1 [Wong, Wai T.; Wang, Minhua] NEI, Unit Neuron Glia Interact Retinal Dis, NIH, Bethesda, MD 20892 USA. [Li, Wei] NEI, Unit Retinal Neurophysiol, NIH, Bethesda, MD 20892 USA. RP Wong, WT (reprint author), NEI, Unit Neuron Glia Interact Retinal Dis, NIH, 6 Ctr Dr,Room 217, Bethesda, MD 20892 USA. EM wongw@nei.nih.gov RI Wong, Wai/B-6118-2017 OI Wong, Wai/0000-0003-0681-4016 FU National Eye Institute Intramural Research Program FX We thank Benjamin Chaon for helpful comments on the manuscript. This work is supported by the National Eye Institute Intramural Research Program. NR 57 TC 10 Z9 10 U1 2 U2 2 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1740-925X J9 NEURON GLIA BIOL JI Neuron Glia Biol. PY 2011 VL 7 IS 1 SI SI BP 41 EP 46 DI 10.1017/S1740925X11000123 PG 6 WC Neurosciences SC Neurosciences & Neurology GA 984FH UT WOS:000307175000005 PM 22166726 ER PT J AU Wake, H Moorhouse, AJ Nabekura, J AF Wake, Hiroaki Moorhouse, Andrew J. Nabekura, Junichi TI Functions of microglia in the central nervous system - beyond the immune response SO NEURON GLIA BIOLOGY LA English DT Article DE Microglia; synapse; synapse stripping ID TUMOR-NECROSIS-FACTOR; SUBVENTRICULAR ZONE; NEURONAL DEATH; IN-VIVO; HIPPOCAMPAL NEUROGENESIS; SYNAPTIC PLASTICITY; CELL-PROLIFERATION; ALZHEIMERS-DISEASE; BRAIN-DEVELOPMENT; OLFACTORY-BULB AB Microglia cells are the immune cells of the central nervous system and consequently play important roles in brain infections and inflammation. Recent in vivo imaging studies have revealed that in the resting healthy brain, microglia are highly dynamic, moving constantly to actively survey the brain parenchyma. These active microglia can rapidly respond to pathological insults, becoming activated to induce a range of effects that may contribute to both pathogenesis, or to confer neuronal protection. However, interactions between microglia and neurons are being recognized as important in shaping neural circuit activity under more normal, physiological conditions. During development and neurogenesis, microglia interactions with neurons help to shape the final patterns of neural circuits important for behavior and with implications for diseases. In the mature brain, microglia can respond to changes in sensory activity and can influence neuronal activity acutely and over the long term. Microglia seem to be particularly involved in monitoring the integrity of synaptic function. In this review, we discuss some of these new insights into the involvement of microglia in neural circuits. C1 [Wake, Hiroaki] NICHHD, Nervous Syst Dev & Plast Sect, NIH, Bethesda, MD 20892 USA. [Moorhouse, Andrew J.] Univ New S Wales, Sch Med Sci, Sydney, NSW, Australia. [Nabekura, Junichi] Natl Inst Physiol Sci, Div Homeostat Dev, Okazaki, Aichi 444, Japan. [Nabekura, Junichi] Grad Univ Adv Studies, Dept Physiol Sci, Hayama, Japan. RP Wake, H (reprint author), NICHD, Nervous Syst Dev & Plast Sect, NIH, Bldg 35,Room 2A213,35 Lincoln Dr, Bethesda, MD 20892 USA. EM wakeh@mail.nih.gov RI Moorhouse, Andrew/B-8526-2011; OI Moorhouse, Andrew/0000-0001-7957-2498 FU National Institute of Child Health and Human Development; Society for the Promotion of Science fellowship FX We gratefully acknowledge R. Douglas Fields and Olena Bukalo for critical reading. This work was supported by the intramural research program at the National Institute of Child Health and Human Development and by a Japan Society for the Promotion of Science fellowship for H. Wake. NR 55 TC 27 Z9 27 U1 4 U2 11 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1740-925X J9 NEURON GLIA BIOL JI Neuron Glia Biol. PY 2011 VL 7 IS 1 SI SI BP 47 EP 53 DI 10.1017/S1740925X12000063 PG 7 WC Neurosciences SC Neurosciences & Neurology GA 984FH UT WOS:000307175000006 PM 22613055 ER PT J AU Sy, MS Altekruse, SF Li, CY Lynch, CF Goodman, MT Hernandez, BY Zhou, L Saber, MS Hewitt, SM Xin, W AF Sy, Man-Sun Altekruse, Sean F. Li, Chaoyang Lynch, Charles F. Goodman, Marc T. Hernandez, Brenda Y. Zhou, Lan Saber, Maria Sibug Hewitt, Stephen M. Xin, Wei TI Association of prion protein expression with pancreatic adenocarcinoma survival in the SEER residual tissue repository SO CANCER BIOMARKERS LA English DT Article DE Pancreas; adenocarcinoma; prion; prp; prognosis; immunohistochemistry; biomarker ID PRO-PRION; CANCER; PROGNOSIS; FILAMIN; BIOMARKERS; BINDING; MARKER AB Pancreatic ductal adenocarcinoma (PDAC) is an important cause of cancer death with no clear prognostic biomarker. Expression of prion (PrP) has been reported to be a marker of poor prognosis in a series of Caucasian PDAC cases. We determined the prognostic value of PrP in a racially and geographically diverse population-based series of PDAC cases. PrP expression was examined in 142 PDAC cases from three cancer registries. Cases included 71 Caucasian, 54 Asian/Pacific Islanders and 17 Blacks diagnosed from 1983-2000, and followed through 2008. Hazard ratios (HR) and 95% confidence intervals (CIs) for the association of PrP expression with survival were computed after adjustment for case attributes. The risk of death was about four times higher (HR = 3.8; 95% CI: 2.2, 6.5) among 108 PDAC cases with PrP+ tumors (median survival 5 months) compared to the 34 cases with PrP- tumors (median survival 20 months). Of 51 cases with resected, localized PDAC median survival was 74 months for 17 cases with PrP- tumors versus 14 months for 34 cases with PrP+ tumors (HR = 6.7; 95% CI: 2.6, 17.4). All 6 surviving cases had PrP- negative tumors (median survival, > 10 years). PrP may have potential as a prognostic biomarker in PDAC patient management. C1 [Xin, Wei] Univ Hosp Case Med Ctr, Dept Pathol, Cleveland, OH 44106 USA. [Sy, Man-Sun; Li, Chaoyang; Zhou, Lan; Xin, Wei] Case Western Reserve Univ, Sch Med, Dept Pathol, Cleveland, OH 44106 USA. [Altekruse, Sean F.] NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA. [Lynch, Charles F.] Univ Iowa, Dept Epidemiol, Iowa City, IA USA. [Goodman, Marc T.; Hernandez, Brenda Y.] Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA. [Saber, Maria Sibug] USC Norris Comprehens Canc Ctr, Dept Pathol, Keck Sch Med, Los Angeles, CA USA. [Saber, Maria Sibug] Hosp Los Angeles, Los Angeles, CA USA. [Hewitt, Stephen M.] NCI, Tissue Array Res Program, Bethesda, MD 20892 USA. RP Xin, W (reprint author), Univ Hosp Case Med Ctr, Dept Pathol, Cleveland, OH 44106 USA. EM wxx10@case.edu OI Hewitt, Stephen/0000-0001-8283-1788 FU Pathology Association of University Hospital of Cleveland Research Grant; Department of Pathology of Case Western Reserve University; SEER (Iowa) [NO1-PC-35143]; SEER (Hawaii) [NO1-PC-35137]; SEER (Los Angeles) [NO1-PC-35139] FX NIH R21CA133559-01 (M-S. S), by Pathology Association of University Hospital of Cleveland Research Grant, and startup fund from Department of Pathology of Case Western Reserve University (W. X.) Intramural Research Program of the NIH, NCI, Center for Cancer Research (S. M. H.). NCI contracts for the participating SEER Registries were NO1-PC-35143 (Iowa), NO1-PC-35137 (Hawaii) and NO1-PC-35139 (Los Angeles). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 16 TC 5 Z9 5 U1 2 U2 4 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 1574-0153 J9 CANCER BIOMARK JI Cancer Biomark. PY 2011 VL 10 IS 6 BP 251 EP 258 DI 10.3233/CBM-2012-0256 PG 8 WC Oncology SC Oncology GA 977LY UT WOS:000306664100001 PM 22820080 ER PT J AU Narfstrom, K Deckman, KH Menotti-Raymond, M AF Narfstroem, Kristina Deckman, Koren Holland Menotti-Raymond, Marilyn TI The Domestic Cat as a Large Animal Model for Characterization of Disease and Therapeutic Intervention in Hereditary Retinal Blindness SO JOURNAL OF OPHTHALMOLOGY LA English DT Review ID ROD-CONE DYSPLASIA; LEBER CONGENITAL AMAUROSIS; GENOME-WIDE ASSOCIATION; RETINITIS-PIGMENTOSA; ABYSSINIAN CATS; CENTROSOMAL PROTEIN; EARLY-ONSET; NEURONAL DIFFERENTIATION; LINKAGE DISEQUILIBRIUM; JOUBERT-SYNDROME AB Large mammals, including canids and felids, are affected by spontaneously occurring hereditary retinal diseases with similarities to those of humans. The large mammal models may be used for thorough clinical characterization of disease processes, understanding the effects of specific mutations, elucidation of disease mechanisms, and for development of therapeutic intervention. Two well-characterized feline models are addressed in this paper. The first model is the autosomal recessive, slowly progressive, late-onset, rod-cone degenerative disease caused by a mutation in the CEP290 gene. The second model addressed in this paper is the autosomal dominant early onset rod cone dysplasia, putatively caused by the mutation found in the CRX gene. Therapeutic trials have been performed mainly in the former type including stem cell therapy, retinal transplantation, and development of ocular prosthetics. Domestic cats, having large human-like eyes with comparable spontaneous retinal diseases, are also considered useful for gene replacement therapy, thus functioning as effective model systems for further research. C1 [Narfstroem, Kristina] Univ Missouri, Coll Vet Med, Dept Vet Med & Surg, Mason Eye Inst, Columbia, MO 65211 USA. [Narfstroem, Kristina] Univ Missouri, Mason Eye Inst, Dept Ophthalmol, Columbia, MO 65212 USA. [Deckman, Koren Holland] Gettysburg Coll, Dept Chem, Gettysburg, PA 17325 USA. [Menotti-Raymond, Marilyn] NCI, Lab Genom Div, Frederick, MD 21702 USA. RP Narfstrom, K (reprint author), Univ Missouri, Coll Vet Med, Dept Vet Med & Surg, Mason Eye Inst, Columbia, MO 65211 USA. EM narfstromk@missouri.edu FU National Cancer Institute, National Institutes of Health [N01-CO-12400]; Lincy Foundation; Discovery Eye Foundation; Grousbeck Family Foundation FX This paper has been funded in part with federal funds from the National Cancer Institute, National Institutes of Health, under contract N01-CO-12400. The authors would like to thank the Lincy Foundation, the Discovery Eye Foundation and the Grousbeck Family Foundation for their financial support. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government. NR 75 TC 10 Z9 10 U1 1 U2 5 PU HINDAWI PUBLISHING CORPORATION PI NEW YORK PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA SN 2090-004X J9 J OPHTHALMOL JI J. Ophthalmol. PY 2011 AR 906943 DI 10.1155/2011/906943 PG 8 WC Medicine, Research & Experimental; Ophthalmology SC Research & Experimental Medicine; Ophthalmology GA 979BO UT WOS:000306790100044 ER PT S AU Lim, PH Bagci, U Aras, O Li, B AF Lim, Poay Hoon Bagci, Ulas Aras, Omer Li, Bai GP IEEE TI Identification of Spinal Vertebrae Using Mathematical Morphology and Level Set Method SO 2011 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE (NSS/MIC) SE IEEE Nuclear Science Symposium Conference Record LA English DT Proceedings Paper CT IEEE Nuclear Science Symposium/Medical Imaging Conference (NSS/MIC)/18th International Workshop on Room-Temperature Semiconductor X-Ray and Gamma-Ray Detectors CY OCT 23-29, 2011 CL Valencia, SPAIN SP IEEE, Inst Elect & Elect Engineers Nucl & Plasma Sci Soc (IEEE NPSS) AB Precise detection and segmentation of spinal vertebrae are crucial in the study of spinal related disease or disorders such as vertebral fractures. Identifying severity of fractures and understanding its causes will help physicians determine the most effective pharmacological treatments and clinical management strategies for spinal disorders. Although image segmentation has been a widely research area, limited work has been done on detecting and segmenting vertebrae. The complexity of vertebrae shapes, gaps in the cortical bone, internal boundaries, as well as the noisy, incomplete or missing information from the medical images have undoubtedly increased the challenge. In this paper, we introduce a new, mathematically driven spinal vertebrae segmentation framework. We first use the traditional image processing techniques, the mathematical morphology and curve fitting to identify the spinal vertebrae and connect them through their centroid. This process is followed by an advanced shape driven level set segmentation, where the level set evolution is guided by a shape constraint and driven by a shape energy coupled with a Gaussian kernel. Experimental results on CT images of spinal vertebrae demonstrate the feasibility of our proposed framework. Our ultimate goal is to provide a quantitative platform for efficient and accurate diagnosis of spinal disorder related diseases. C1 [Lim, Poay Hoon; Li, Bai] Univ Nottingham, Sch Comp Sci, Nottingham NG8 1BB, England. [Bagci, Ulas] NIH, Bethesda, MD 20892 USA. [Aras, Omer] NCI, Mol Imaging Ctr, Bethesda, MD 20892 USA. RP Lim, PH (reprint author), Univ Nottingham, Sch Comp Sci, Nottingham NG8 1BB, England. EM phl@cs.nott.ac.uk; ulas.bagci@nih.gov; dromeraras@gmail.com; bai@cs.nott.ac.uk NR 8 TC 1 Z9 1 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1082-3654 BN 978-1-4673-0120-6 J9 IEEE NUCL SCI CONF R PY 2011 BP 3105 EP 3107 PG 3 WC Engineering, Electrical & Electronic; Physics, Applied; Imaging Science & Photographic Technology; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Physics; Imaging Science & Photographic Technology; Radiology, Nuclear Medicine & Medical Imaging GA BAM64 UT WOS:000304755603075 ER PT J AU Dzik, WH Blajchman, MA Fergusson, D Hameed, M Henry, B Kirkpatrick, AW Korogyi, T Logsetty, S Skeate, RC Stanworth, S MacAdams, C Muirhead, B AF Dzik, Walter H. Blajchman, Morris A. Fergusson, Dean Hameed, Morad Henry, Blair Kirkpatrick, Andrew W. Korogyi, Teresa Logsetty, Sarvesh Skeate, Robert C. Stanworth, Simon MacAdams, Charles Muirhead, Brian TI Clinical review: Canadian National Advisory Committee on Blood and Blood Products - Massive Transfusion Consensus Conference 2011: report of the panel SO CRITICAL CARE LA English DT Review ID FRESH-FROZEN PLASMA; RESPIRATORY-DISTRESS-SYNDROME; BLEEDING TRAUMA PATIENTS; MAJOR TRAUMA; COAGULATION ABNORMALITIES; INTRACEREBRAL HEMORRHAGE; ACUTE COAGULOPATHY; CELL TRANSFUSION; PROTHROMBIN TIME; CONTROLLED-TRIAL AB In June 2011 the Canadian National Advisory Committee on Blood and Blood Products sponsored an international consensus conference on transfusion and trauma. A panel of 10 experts and two external advisors reviewed the current medical literature and information presented at the conference by invited international speakers and attendees. The Consensus Panel addressed six specific questions on the topic of blood transfusion in trauma. The questions focused on: ratio-based blood resuscitation in trauma patients; the impact of survivorship bias in current research conclusions; the value of nonplasma coagulation products; the role of protocols for delivery of urgent transfusion; the merits of traditional laboratory monitoring compared with measures of clot viscoelasticity; and opportunities for future research. Key findings include a lack of evidence to support the use of 1:1:1 blood component ratios as the standard of care, the importance of early use of tranexamic acid, the expected value of an organized response plan, and the recommendation for an integrated approach that includes antifibrinolytics, rapid release of red blood cells, and a foundation ratio of blood components adjusted by results from either traditional coagulation tests or clot viscoelasticity or both. The present report is intended to provide guidance to practitioners, hospitals, and policy-makers. C1 [Dzik, Walter H.] Massachusetts Gen Hosp, Blood Transfus Serv, Boston, MA 02114 USA. [Blajchman, Morris A.] McMaster Univ, Med Ctr, Dept Pathol, Canadian Blood Serv, Hamilton, ON L8N 3Z5, Canada. [Blajchman, Morris A.] McMaster Univ, Med Ctr, Dept Med, Canadian Blood Serv, Hamilton, ON L8N 3Z5, Canada. [Blajchman, Morris A.] NHLBI TMH Clin Trials Network, Bethesda, MD USA. [Fergusson, Dean] Univ Ottawa, Ottawa Hosp Res Inst, Fac Med, Dept Clin Epidemiol,Clin Epidemiol Program, Ottawa, ON K1H 8L6, Canada. [Hameed, Morad] Univ British Columbia, Vancouver Gen Hosp, Dept Surg & Crit Care Med, Trauma Serv,Gen Surg Residency Program, Vancouver, BC V5Z 1M9, Canada. [Henry, Blair] Univ Toronto, Sunnybrook Hlth Sci Ctr, Joint Ctr Bioeth, Sunnybrook Hlth Sci Ctr,Dept Family & Community M, Toronto, ON M4N 3M5, Canada. [Kirkpatrick, Andrew W.] Univ Calgary, Foothills Med Ctr, Dept Crit Care Med & Surg, Reg Trauma Serv, Calgary, AB T2N 2T9, Canada. [Korogyi, Teresa] Sunnybrook Hlth Sci Ctr, Emergency Dept, Toronto, ON M4N 3M5, Canada. [Logsetty, Sarvesh] Univ Manitoba, Manitoba Firefighters Burn Unit, Winnipeg, MB R3A 1R9, Canada. [Skeate, Robert C.] Univ Toronto, Dept Lab Med & Pathobiol, Canadian Blood Serv Cent Ontario Reg, Toronto, ON M5G 2M1, Canada. [Stanworth, Simon] Univ Oxford, John Radcliffe Hosp, Dept Haematol, Oxford OX3 9DU, England. [MacAdams, Charles] Foothills Med Ctr, Dept Anesthesia, Perioperat Blood Conservat Program Calgary Zone, Calgary, AB T2N 2T9, Canada. [Muirhead, Brian] Univ Manitoba, Dept Anesthesiol, Blood Conservat Serv, Transfus Practices Comm, Winnipeg, MB R3M 3E8, Canada. RP Dzik, WH (reprint author), Massachusetts Gen Hosp, Blood Transfus Serv, 55 Fruit St, Boston, MA 02114 USA. EM sdzik@partners.org FU Canadian National Advisory Committee on Blood and Blood Products FX The Canadian National Advisory Committee on Blood and Blood Products provided funding. The authors wish to acknowledge the Planning Committee of the Massive Transfusion Consensus Conference who organized the meeting, formulated the questions to the panel, and invited the speakers who presented data at the meeting. The planning committee members were: Sandro Rizoli (chairman) (Sunnybrook Health Sciences Centre, Toronto, Canada); Jeannie Callum (Sunnybrook Health Sciences Centre, Toronto, Canada); Cheryl Doncaster (Department of Health and Community Services, Newfoundland and Labrador, Canada); David Howe (Canadian Blood Services, Ottawa, Canada); Catherine Moltzan (Winnipeg Regional Health Authority, Winnipeg, Canada); Susan Nahirniak (University of Alberta Hospital, Edmonton, Canada); Bartolomeu Nascimento (Sunnybrook Health Sciences Centre, Toronto, Canada); Katerina Pavenski (St Michael's Hospital, Toronto, Canada); Homer Tien (Sunnybrook Health Sciences Centre, Toronto, Canada); and Lucinda Whitman (Eastern Health, Newfoundland and Labrador, Canada). NR 97 TC 66 Z9 67 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1466-609X J9 CRIT CARE JI Crit. Care PY 2011 VL 15 IS 6 AR 242 DI 10.1186/cc10498 PG 12 WC Critical Care Medicine SC General & Internal Medicine GA 969VJ UT WOS:000306087200009 PM 22188866 ER PT J AU Han, SH Martin, GS Maloney, JP Shanholtz, C Barnes, KC Murray, S Sevransky, JE AF Han, SeungHye Martin, Greg S. Maloney, James P. Shanholtz, Carl Barnes, Kathleen C. Murray, Stacey Sevransky, Jonathan E. TI Short women with severe sepsis-related acute lung injury receive lung protective ventilation less frequently: an observational cohort study SO CRITICAL CARE LA English DT Article ID RESPIRATORY-DISTRESS-SYNDROME; CRITICALLY-ILL PATIENTS; MECHANICAL VENTILATION; MYOCARDIAL-INFARCTION; CONSENSUS CONFERENCE; TRAUMA-HEMORRHAGE; INTENSIVE-CARE; CLINICAL-TRIAL; UNITED-STATES; GENDER AB Introduction: Lung protective ventilation (LPV) has been shown to improve survival and the duration of mechanical ventilation in acute lung injury (ALI) patients. Mortality of ALI may vary by gender, which could result from treatment variability. Whether gender is associated with the use of LPV is not known. Methods: A total of 421 severe sepsis-related ALI subjects in the Consortium to Evaluate Lung Edema Genetics from seven teaching hospitals between 2002 and 2008 were included in our study. We evaluated patients' tidal volume, plateau pressure and arterial pH to determine whether patients received LPV during the first two days after developing ALI. The odds ratio of receiving LPV was estimated by a logistic regression model with robust and cluster options. Results: Women had similar characteristics as men with the exception of lower height and higher illness severity, as measured by Acute Physiology and Chronic Health Evaluation (APACHE) II score. 225 (53%) of the subjects received LPV during the first two days after ALI onset; women received LPV less frequently than men (46% versus 59%, P < 0.001). However, after adjustment for height and severity of illness (APACHE II), there was no difference in exposure to LPV between men and women (P = 0.262). Conclusions: Short people are less likely to receive LPV, which seems to explain the tendency of clinicians to adhere to LPV less strictly in women. Strategies to standardize application of LPV, independent of differences in height and severity of illness, are necessary. C1 [Han, SeungHye] NIH, Dept Crit Care Med, Bethesda, MD 20892 USA. [Martin, Greg S.] Emory Univ, Div Pulm Allergy & Crit Care, Atlanta, GA 30303 USA. [Maloney, James P.] Univ Colorado, Div Pulm Sci & Crit Care Med, Denver, CO 80262 USA. [Shanholtz, Carl] Univ Maryland, Div Pulm & Crit Care, Baltimore, MD 21201 USA. [Barnes, Kathleen C.] Johns Hopkins Univ, Div Allergy & Clin Immunol, Baltimore, MD 21224 USA. [Murray, Stacey; Sevransky, Jonathan E.] Johns Hopkins Univ, Div Pulm & Crit Care Med, Baltimore, MD 21224 USA. RP Han, SH (reprint author), NIH, Dept Crit Care Med, 10 Ctr Dr, Bethesda, MD 20892 USA. EM shan@jhsph.edu RI maloney, james/K-9428-2015; OI maloney, james/0000-0001-8348-4650; Shanholtz, Carl/0000-0003-3938-178X; Martin, Greg/0000-0002-9684-7593 FU National Heart, Blood, and Lung Institute Specialized Centers of Clinically Oriented Research (SCCOR) [P050 HL]; National Institutes of Health [K-23 GMO7-1399]; Mary Beryl Patch Turnbull Scholar Program FX The authors are grateful to all the study coordinators for recruitment of subjects into the Consortium to Evaluate Lung Edema Genetics (CELEG). This research was supported by a National Heart, Blood, and Lung Institute Specialized Centers of Clinically Oriented Research (SCCOR) grant in Acute Lung Injury SCCOR grant P050 HL. JES is supported by National Institutes of Health K-23 GMO7-1399. KCB is supported by Mary Beryl Patch Turnbull Scholar Program. NR 33 TC 18 Z9 18 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1466-609X J9 CRIT CARE JI Crit. Care PY 2011 VL 15 IS 6 AR R262 DI 10.1186/cc10524 PG 8 WC Critical Care Medicine SC General & Internal Medicine GA 969VJ UT WOS:000306087200056 PM 22044724 ER PT J AU Mikami, K Suzuki, M Kitagawa, H Kawakami, M Hirota, N Shimbara-Mikami, A Sakamoto, Y AF Mikami, Katsunaka Suzuki, Masaru Kitagawa, Hiroshi Kawakami, Masaki Hirota, Nobuaki Shimbara-Mikami, Ayako Sakamoto, Yoshio TI Severity of community-acquired pneumonia treated with low-dose adjunctive corticosteroid SO CRITICAL CARE LA English DT Letter C1 [Suzuki, Masaru; Kawakami, Masaki; Sakamoto, Yoshio] Kanto Cent Hosp, Dept Internal Med, Setagaya Ku, Tokyo 1588531, Japan. [Mikami, Katsunaka] Tokai Univ, Sch Med, Dept Psychiat, Isehara, Kanagawa 2591193, Japan. [Kitagawa, Hiroshi] NCI, Ctr Canc Res, Med Oncol Branch, Bethesda, MD 20892 USA. [Hirota, Nobuaki] McGill Univ, Dept Med, Meakins Christie Labs, Montreal, PQ, Canada. [Shimbara-Mikami, Ayako] Tokai Univ, Sch Med, Dept Clin Pharmacol, Isehara, Kanagawa 2591193, Japan. RP Suzuki, M (reprint author), Kanto Cent Hosp, Dept Internal Med, Setagaya Ku, 6-25-1 Kamiyoga, Tokyo 1588531, Japan. EM masaruszk@aol.com NR 0 TC 0 Z9 0 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1466-609X J9 CRIT CARE JI Crit. Care PY 2011 VL 15 IS 6 AR 451 DI 10.1186/cc10500 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 969VJ UT WOS:000306087200019 PM 22071207 ER PT S AU Sun, Y Haseltine, F Cork, J Lockett, E Chang, F Chen, L AF Sun, Ying Haseltine, Florence Cork, John Lockett, Elizabeth Chang, Florence Chen, Lucie BE Xing, CX Crestani, F Rauber, A TI Embryo App for iPhone/iPad/iPod Touch SO DIGITAL LIBRARIES: FOR CULTURAL HERITAGE, KNOWLEDGE DISSEMINATION, AND FUTURE CREATION: ICADL 2011 SE Lecture Notes in Computer Science LA English DT Proceedings Paper CT 13th International Conference on Asia-Pacific Digital Libraries (ICADL 2011) CY OCT 24-27, 2011 CL Tsinghua Univ, Beijing, PEOPLES R CHINA SP Peking Univ, Natl Lib China HO Tsinghua Univ DE Mobile app; iPhone; database; Embryo; 2D images; 3D animations AB Scientists and educators worldwide use the Carnegie Collection of Embryology to define normal human embryo development for decades. The Embryo App for iPhone/iPad and iPod Touch, developed by National Library of Medicine (NLM), utilizes mobile telecommunication and multimedia technologies to add interactive capabilities to the embryo data, enhancing our understanding of embryo development. Embryo is a collaborative project between NLM, the Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), Louisiana State University Health Sciences Center (LSUHSC) and National Museum of Health & Medicine's Human Developmental Anatomy Center (NMHM & HDAC). This App is part of the National Library of Medicine's program to fulfill the NLM's role as a provider of medical, science and health care information with mobile technologies. The Embryo App provides a new venue for us to access and interact with the Carnegie Collection of Embryology for the first time. C1 [Sun, Ying; Chang, Florence; Chen, Lucie] NIH, Natl Lib Med, 6707 Democracy Blvd Suite 510, Bethesda, MD 20892 USA. [Haseltine, Florence] NICHHD, Rockville, MD USA. [Cork, John] Louisiana State Univ Hlth Sci Ctr, New Orleans, LA USA. [Lockett, Elizabeth] Natl Museum Hlth & Med, Silver Spring, MD USA. RP Sun, Y (reprint author), NIH, Natl Lib Med, 6707 Democracy Blvd Suite 510, Bethesda, MD 20892 USA. EM yingsun@mail.nih.gov NR 0 TC 0 Z9 0 U1 0 U2 4 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0302-9743 BN 978-3-642-24825-2 J9 LECT NOTES COMPUT SC PY 2011 VL 7008 BP 377 EP + PG 2 WC Computer Science, Information Systems; Computer Science, Theory & Methods; Information Science & Library Science SC Computer Science; Information Science & Library Science GA BBA17 UT WOS:000306259000048 ER PT J AU Dillon, DG Deveney, CM Pizzagalli, DA AF Dillon, Daniel G. Deveney, Christen M. Pizzagalli, Diego A. TI From Basic Processes to Real-World Problems: How Research on Emotion and Emotion Regulation Can Inform Understanding of Psychopathology, and Vice Versa SO EMOTION REVIEW LA English DT Article DE affective neuroscience; emotion; emotion regulation; fear; psychopathology; reward ID FEAR-POTENTIATED STARTLE; SOCIAL ANXIETY DISORDER; MAJOR DEPRESSION; D-CYCLOSERINE; CONDITIONED FEAR; PANIC DISORDER; EXPOSURE THERAPY; NEGATIVE EMOTION; AFFECTIVE NEUROSCIENCE; INDIVIDUAL-DIFFERENCES AB Research on emotion and emotion regulation is expected to improve our understanding of psychopathology. However, achieving this understanding requires overcoming several obstacles, including the paucity of objective markers of specific emotions or psychiatric diagnoses, and the fact that emotion regulation is a concept that can be difficult to operationalize. We review affective neuroscience research that has addressed these issues by focusing on psychological and neural mechanisms implicated in approach and avoidance behaviors, as revealed by studies of fear, anxiety, and reward processing. Dysfunction in these mechanisms may serve as risk markers for psychopathology, while emotion regulation research demonstrates that some of them are susceptible to volitional control. The conclusion acknowledges limitations of affective neuroscience and highlights goals for future work. C1 [Dillon, Daniel G.; Pizzagalli, Diego A.] Harvard Univ, McLean Hosp, Sch Med, Ctr Depress Stress & Anxiety Res, Belmont, MA 02478 USA. [Deveney, Christen M.] NIMH, Emot & Dev Branch, Bethesda, MD 20892 USA. RP Dillon, DG (reprint author), Harvard Univ, McLean Hosp, Sch Med, Ctr Depress Stress & Anxiety Res, 233B deMarneffe Bldg,115 Mill St, Belmont, MA 02478 USA. EM dillon@wjh.harvard.edu OI Dillon, Daniel/0000-0002-1977-700X FU NCCIH NIH HHS [R21 AT002974, R21 AT002974-01A1, R21 AT002974-02]; NIMH NIH HHS [F32 MH081394, F32 MH081394-01A2, F32 MH081394-02, R01 MH068376, R01 MH068376-01A1, R01 MH068376-02, R01 MH068376-03, R01 MH068376-04, R01 MH068376-05, R01 MH068376-06A1, R21 MH078979, R21 MH078979-01A2, R21 MH078979-02] NR 88 TC 15 Z9 15 U1 11 U2 28 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1754-0739 J9 EMOT REV JI Emot. Rev. PD JAN PY 2011 VL 3 IS 1 BP 74 EP 82 DI 10.1177/1754073910380973 PG 9 WC Psychology, Multidisciplinary SC Psychology GA 972IT UT WOS:000306271500009 PM 21584224 ER PT B AU Paik, SJ AF Paik, Susan J. BE Redding, S Murphy, M Sheley, P TI Minority Families and Schooling SO HANDBOOK ON FAMILY AND COMMUNITY ENGAGEMENT LA English DT Article; Book Chapter C1 [Paik, Susan J.] Claremont Grad Univ, Sch Educ, Urban Leadership Program, Claremont, CA USA. [Paik, Susan J.] NIMH, Bethesda, MD USA. RP Paik, SJ (reprint author), Claremont Grad Univ, Sch Educ, Urban Leadership Program, Claremont, CA USA. NR 25 TC 0 Z9 0 U1 0 U2 2 PU INFORMATION AGE PUBLISHING-IAP PI CHARLOTTE PA PO BOX 79049, CHARLOTTE, NC 28271-7047 USA BN 978-1-61735-668-1 PY 2011 BP 121 EP 124 PG 4 WC Education & Educational Research; Family Studies SC Education & Educational Research; Family Studies GA BAC13 UT WOS:000303779400025 ER PT S AU Yang, X Lauzon, CB Crainiceanu, C Caffo, B Resnick, SM Landman, BA AF Yang, Xue Lauzon, Carolyn B. Crainiceanu, Ciprian Caffo, Brian Resnick, Susan M. Landman, Bennett A. BE Liu, T Shen, D Ibanez, L Tao, X TI Accounting for Random Regressors: A Unified Approach to Multi-modality Imaging SO MULTIMODAL BRAIN IMAGE ANALYSIS SE Lecture Notes in Computer Science LA English DT Proceedings Paper CT 1st International Workshop on Multimodal Brain Image Analysis (MBIA 2011) CY SEP 18, 2011 CL Toronto, CANADA DE Model II regression; Inference; Statistical parametric mapping; Biological parametric mapping; model fitting AB Massively univariate regression and inference in the form of statistical parametric mapping have transformed the way in which multidimensional imaging data are studied. In functional and structural neuroimaging, the de facto standard "design matrix"-based general linear regression model and its multi-level cousins have enabled investigation of the biological basis of the human brain. With modern study designs, it is possible to acquire multiple three-dimensional assessments of the same individuals e.g., structural, functional and quantitative magnetic resonance imaging alongside functional and ligand binding maps with positron emission tomography. Current statistical methods assume that the regressors are non-random. For more realistic multi-parametric assessment (e.g., voxel-wise modeling), distributional consideration of all observations is appropriate (e.g., Model II regression). Herein, we describe a unified regression and inference approach using the design matrix paradigm which accounts for both random and non-random imaging regressors. C1 [Yang, Xue; Lauzon, Carolyn B.; Landman, Bennett A.] Vanderbilt Univ, Elect Engn, 221 Kirkland Hall, Nashville, TN 37235 USA. [Crainiceanu, Ciprian; Caffo, Brian] Johns Hopkins Univ, Dept Biostat, Baltimore, MD USA. [Resnick, Susan M.] NIH, NIA, Baltimore, MD USA. RP Yang, X (reprint author), Vanderbilt Univ, Elect Engn, 221 Kirkland Hall, Nashville, TN 37235 USA. EM Xue.Yang@vanderbilt.edu; Carolyn.Lauzon@vanderbilt.edu; ccrainic@jhsph.edu; bcaffo@jhsph.edu; resnicks@grc.nia.nih.gov; Bennett.Landman@vanderbilt.edu FU NIH [N01-AG-4-0012] FX This project was supported by NIH N01-AG-4-0012. This work described herein has not been submitted elsewhere for publication. NR 11 TC 2 Z9 2 U1 0 U2 2 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0302-9743 BN 978-3-642-24445-2 J9 LECT NOTES COMPUT SC PY 2011 VL 7012 BP 1 EP + PG 3 WC Computer Science, Theory & Methods; Radiology, Nuclear Medicine & Medical Imaging SC Computer Science; Radiology, Nuclear Medicine & Medical Imaging GA BBB49 UT WOS:000306341700001 ER PT J AU Andrade, LR Manor, U Kachar, B AF Andrade, L. R. Manor, U. Kachar, B. TI Adult hair cell stereocilia actin cores undergo dynamic renewal. SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Andrade, L. R.; Manor, U.; Kachar, B.] NIDCD, NIH, Bethesda, MD USA. [Andrade, L. R.] Univ Fed Rio de Janeiro, Inst Biomed Sci, Rio De Janeiro, Brazil. RI Andrade, Leonardo/C-9554-2011 OI Andrade, Leonardo/0000-0002-0004-5677 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 1404 PG 2 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505502517 ER PT J AU Brownlee, CW Klebba, JE Buster, DW Rusan, NM Rogers, GC AF Brownlee, C. W. Klebba, J. E. Buster, D. W. Rusan, N. M. Rogers, G. C. TI SV40 small tumor antigen exploits PP2A's role in stabilizing Plk4 to induce centriole amplification. SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Brownlee, C. W.; Klebba, J. E.; Buster, D. W.; Rogers, G. C.] Univ Arizona, Tucson, AZ USA. [Rusan, N. M.] NHLBI, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 893 PG 2 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505502011 ER PT J AU Burnette, D Sengupta, P Dai, Y Lippincott-Schwartz, J Kachar, B AF Burnette, D. Sengupta, P. Dai, Y. Lippincott-Schwartz, J. Kachar, B. TI Bleaching/blinking assisted localization microscopy (BALM) for super-resolution imaging using standard fluorescent molecules SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Burnette, D.; Sengupta, P.; Lippincott-Schwartz, J.] NICHHD, CBMB, NIH, Bethesda, MD 20892 USA. [Dai, Y.; Kachar, B.] Natl Inst Deafness & Other Commun Disorders, NIH, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 2 U2 4 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 62 PG 2 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505500063 ER PT J AU Case, C Wangsa, D Sackett, D Ried, T Camps, J AF Case, C. Wangsa, D. Sackett, D. Ried, T. Camps, J. TI Depletion of Spindle Pole Protein, CKAP2, Increases Chromosomal Instability in Colorectal Cancer Cells. SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Case, C.; Wangsa, D.; Ried, T.; Camps, J.] NCI, NIH, Bethesda, MD 20892 USA. [Case, C.] George Washington Univ, Inst Biomed Sci, Washington, DC USA. [Sackett, D.] NICHHD, NIH, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 1430 PG 2 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505503018 ER PT J AU Chen, WC Heim, E Hale, CM Lee, JS Wirtz, D AF Chen, W-C. Heim, E. Hale, C. M. Lee, J. S. Wirtz, D. TI Distinctive Cell Polarization Mechanisms Depend on Cell Shape and Cell-Cell Contacts. SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Chen, W-C.; Hale, C. M.; Lee, J. S.; Wirtz, D.] Johns Hopkins Univ, Baltimore, MD USA. [Chen, W-C.; Hale, C. M.; Wirtz, D.] Johns Hopkins Phys Sci Oncol Ctr, Baltimore, MD USA. [Lee, J. S.] NCI, Ctr Strateg Sci Initiat, Bethesda, MD 20892 USA. [Heim, E.] Univ Florida, Gainesville, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 647 PG 1 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505501200 ER PT J AU Chow, KH Elgort, S Dasso, M Ullman, K AF Chow, K-H. Elgort, S. Dasso, M. Ullman, K. TI The SUMO proteases SENP1 and SENP2 bind to Nup153 and control a cycle of SUMO modification of this nucleoporin. SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Chow, K-H.; Elgort, S.; Ullman, K.] Univ Utah, Salt Lake City, UT USA. [Dasso, M.] Natl Inst Hlth, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 476 PG 1 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505501029 ER PT J AU Dobrinskikh, E Okamura, K Kopp, J Blaine, J Doctor, RB AF Dobrinskikh, E. Okamura, K. Kopp, J. Blaine, J. Doctor, R. B. TI Shank2 traffics with albumin-laden endosomes in human podocytes. SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Dobrinskikh, E.; Okamura, K.; Blaine, J.; Doctor, R. B.] Univ Colorado, Dept Med, Aurora, CO USA. [Kopp, J.] NIDDK, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 451 PG 2 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505501004 ER PT J AU Eckley, DM Rahimi, S Orlov, NV Mantilla, S Coletta, CE Delaney, JD Zhang, Y Becker, K Iser, W Wilson, M Goldberg, IG AF Eckley, D. M. Rahimi, S. Orlov, N. V. Mantilla, S. Coletta, C. E. Delaney, J. D. Zhang, Y. Becker, K. Iser, W. Wilson, M. Goldberg, I. G. TI Two distinguishable aging states found in an isogenic population at a single chronological age. 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TI Mechanistic model for ESCRT mediated cytokinetic abscission SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Elia, N.; Lippincoot-Schwartz, J.] NICHD, NIH, Bethesda, MD USA. [Fabrikant, G.; Kozlov, M. M.] Tel Aviv Univ, Sch Med, Dept Physiol & Pharmacol, Tel Aviv, Israel. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 530 PG 2 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505501083 ER PT J AU Eromobor, I Petrie, RJ Gutierrez, N Yamada, KM Rodriguez, AJ AF Eromobor, I. Petrie, R. J. Gutierrez, N. Yamada, K. M. Rodriguez, A. J. TI Epithelial Contact Expansion Requires de novo mRNA Translation SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Eromobor, I.; Gutierrez, N.; Rodriguez, A. J.] Rutgers State Univ, Newark, NJ 07102 USA. [Petrie, R. J.; Yamada, K. M.] NIDCR, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 1575 PG 1 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505503160 ER PT J AU Fischer, RS Elliott, HS Waterman, CM Danuser, G AF Fischer, R. S. Elliott, H. S. Waterman, C. M. Danuser, G. TI Automated Surface Tracking and Morphodynamics Quantification of Endothelial Cells in 3D Gels SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Fischer, R. S.; Waterman, C. M.] NHLBI, NIH, Bethesda, MD 20892 USA. [Elliott, H. S.; Danuser, G.] Harvard Univ, Sch Med, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 932 PG 1 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505502050 ER PT J AU Fu, D Mitra, K Sengupta, P Lippincott-Schwartz, J Arias, I AF Fu, D. Mitra, K. Sengupta, P. Lippincott-Schwartz, J. Arias, I. TI Mitochondrial fusion regulates hepatocyte polarization. SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Fu, D.; Sengupta, P.; Lippincott-Schwartz, J.] NICHD, NIH, Bethesda, MD USA. [Mitra, K.; Arias, I.] NHLBI, NIH, Bethesda, MD 20892 USA. RI Fu, Dong /J-1426-2012 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 1303 PG 1 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505502417 ER PT J AU Giovinazzi, S Morozov, V Reinhold, WC Ishov, AM AF Giovinazzi, S. Morozov, V. Reinhold, W. C. Ishov, A. M. TI Daxx and USP7: novel regulators of genomic stability, mitosis and taxanes sensitivity SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Reinhold, W. C.] NCI, Genom & Bioinformat Grp, NIH, Bethesda, MD 20892 USA. [Ishov, A. M.] Univ Florida, Shands Canc Ctr, Gainesville, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 2269 PG 1 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505504298 ER PT J AU Gudheti, MV Gould, TJ Kim, D Curthoys, NM Gabor, KA Gunewardene, MS Verkhusha, VV Zimmerberg, J Gosse, JA Kim, CH Hess, ST AF Gudheti, M. V. Gould, T. J. Kim, D. Curthoys, N. M. Gabor, K. A. Gunewardene, M. S. Verkhusha, V. V. Zimmerberg, J. Gosse, J. A. Kim, C. H. Hess, S. T. 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TI Stereoscopic transmission electron microscopy of Maurer's Clefts in "unroofed" specimens of Plasmodium falciparum-infected erythrocytes SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Hayakawa, E. H.; Matsuoka, H.] Jichi Med Univ, Lab Med Zool & Parasitol, Dept Infect & Immun, Shimotsuke, Japan. [Tokumasu, F.; Wellems, T. E.] NIAID, Lab Malaria & Vector Res, NIH, Bethesda, MD 20892 USA. [Usukura, J.] Nagoya Univ, EcoTopia Sci Inst, Div Integrated Project, Nagoya, Aichi 4648601, Japan. [Tuboi, T.] Ehime Univ, Cell Free Sci & Technol Res Ctr, Malaria Res Unit, Matsuyama, Ehime, Japan. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 764 PG 1 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505501317 ER PT J AU Hendrix, A Westbroek, W De Wever, O AF Hendrix, A. Westbroek, W. De Wever, O. TI The small GTPase Rab27B regulates invasive tumor growth and metastasis through extracellular HSP90 alpha. SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Hendrix, A.; De Wever, O.] Univ Ghent, B-9000 Ghent, Belgium. [Westbroek, W.] NIH, Bethesda, MD 20892 USA. RI de wever, olivier/J-3094-2013 OI de wever, olivier/0000-0002-5453-760X NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. 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Cell PY 2011 VL 22 MA 1031 PG 1 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505502147 ER PT J AU Horn, H Dror, A Roux, K Kozlov, S Avraham, K Burke, B Stewart, C AF Horn, H. Dror, A. Roux, K. Kozlov, S. Avraham, K. Burke, B. Stewart, C. TI The KASH Domain Protein Nesprin 4 is essential for cochlear outer hair cell maintenance and hearing SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Horn, H.; Burke, B.; Stewart, C.] Inst Med Biol, Singapore, Singapore. [Dror, A.; Avraham, K.] Tel Aviv Univ, IL-69978 Tel Aviv, Israel. [Roux, K.] Sanford Childrens Hlth Res Ctr, Sioux Falls, SD USA. [Kozlov, S.] NCI, Frederick, MD 21701 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 49 PG 1 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505500050 ER PT J AU Joseph-Strauss, D Gorjanacz, M Voronina, E Audhya, A Cohen-Fix, O AF Joseph-Strauss, D. Gorjanacz, M. Voronina, E. Audhya, A. Cohen-Fix, O. TI Sm protein down-regulation leads to defects in nuclear pore complex disassembly and distribution in C. elegans embryos. SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Joseph-Strauss, D.] NIH, Bethesda, MD 20892 USA. [Gorjanacz, M.] European Mol Biol Lab, Heidelberg, Germany. [Voronina, E.] Johns Hopkins Sch Med, Baltimore, MD USA. [Audhya, A.] Univ Wisconsin Madison Med Sch, Madison, WI USA. [Cohen-Fix, O.] NIDDK NIH, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. 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Cheng, M. Hao, H. Fan, C-M. Gaiano, N. Ko, M. Zheng, Y. TI B-type lamins regulates neither their bound genes nor embryonic stem cells but are essential for organogenesis SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Kim, Y.; Mcdole, K.; Fan, C-M.; Zheng, Y.] Carnegie Inst Sci, Baltimore, MD USA. [Sharov, A.; Ko, M.] NIA, Dev Genom & Aging Sect, NIH, Baltimore, MD 21224 USA. [Cheng, M.; Gaiano, N.] Johns Hopkins Univ, Dept Neurosci, Baltimore, MD 21218 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 1091 PG 1 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505502206 ER PT J AU Kim, Y Sharov, A Mcdole, K Cheng, M Hao, H Fan, CM Gaiano, N Ko, M Zheng, Y AF Kim, Y. Sharov, A. Mcdole, K. Cheng, M. Hao, H. Fan, C-M. Gaiano, N. Ko, M. Zheng, Y. TI B-type lamins regulates neither their bound genes nor embryonic stem cells but are essential for organogenesis SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Kim, Y.; Mcdole, K.; Fan, C-M.; Zheng, Y.] Carnegie Inst Sci, Baltimore, MD USA. [Sharov, A.; Ko, M.] NIA, Dev Genom & Aging Sect, NIH, Baltimore, MD 21224 USA. [Cheng, M.; Gaiano, N.] Johns Hopkins Univ, Dept Neurosci, Baltimore, MD USA. [Hao, H.] JHMI, Microarray Core Facil, Baltimore, MD USA. RI Ko, Minoru/B-7969-2009 OI Ko, Minoru/0000-0002-3530-3015 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 50 PG 1 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505500051 ER PT J AU Klebba, JE Buster, DW Rusan, NM Rogers, GC AF Klebba, J. E. Buster, D. W. Rusan, N. M. Rogers, G. C. TI Polo-like kinase 4 stability is controlled by autophosphorylation of multiple residues within its downstream regulatory element. SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Klebba, J. E.; Buster, D. W.; Rogers, G. C.] Univ Arizona, Tucson, AZ USA. [Rusan, N. M.] NHLBI, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 892 PG 1 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505502010 ER PT J AU Lam, PY Fischer, RS Waterman, CM Huttenlocher, A AF Lam, P-Y. Fischer, R. S. Waterman, C. M. Huttenlocher, A. TI F-actin dynamics and actomyosin contraction during neutrophil motility in live zebrafish SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Lam, P-Y.; Huttenlocher, A.] Univ Wisconsin, Madison, WI USA. [Fischer, R. S.; Waterman, C. M.] NHLBI, Cell Biol & Physiol Ctr, NIH, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 338 PG 1 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505500337 ER PT J AU Laughlin, RC Knodler, LA Payne, HR Mouneimne, RB Steele-Mortimer, O Adams, LG AF Laughlin, R. C. Knodler, L. A. Payne, H. R. Mouneimne, R. B. Steele-Mortimer, O. Adams, L. G. TI Salmonella enterica Typhimurium associated with enterocyte extrusion in an in vivo bovine enteric infection model SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Laughlin, R. C.; Payne, H. R.; Mouneimne, R. B.; Adams, L. G.] Texas A&M Univ, College Stn, TX USA. [Knodler, L. A.; Steele-Mortimer, O.] NIH, Rocky Mt Labs, Hamilton, MT USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 1200 PG 2 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505502315 ER PT J AU Ma, X Kovacs, M Adelstein, RS AF Ma, X. Kovacs, M. Adelstein, R. S. TI Nonmuscle Myosin II Drives Contractile Ring Constriction by Exerting Tension on but not Translocating Actin-Filaments SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Ma, X.; Adelstein, R. S.] NHLBI, Mol Cardiol Lab, NIH, Bethesda, MD 20892 USA. [Kovacs, M.] Eotvos Lorand Univ, ELTE MTA Momentum Motor Enzymol Res Grp, Dept Biochem, H-1364 Budapest, Hungary. RI Kovacs, Mihaly/A-6841-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 293 PG 2 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505500292 ER PT J AU Malicdan, MC Noguchi, S Tokutomi, T Hayashi, YK Goto, YI Nishino, I AF Malicdan, M. C. Noguchi, S. Tokutomi, T. Hayashi, Y. K. Goto, Y-I. Nishino, I. TI Peracetylated N-acetylmannosamine, a synthetic sugar molecule, unravels important biomarkers in a mouse model of sialic acid deficient myopathy SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Malicdan, M. C.] NHGRI, NIH, Bethesda, MD 20892 USA. [Malicdan, M. C.; Noguchi, S.] Natl Inst Neurosci, Dept Neuromuscular Res, Kodaira, Tokyo 187, Japan. [Goto, Y-I.] Natl Inst Neurosci, Dept Mental Retardat & Birth Defect Res, Kodaira, Tokyo 187, Japan. RI Malicdan, May Christine/F-2806-2013 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 393 PG 1 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505500392 ER PT J AU Osborne, LD Cribb, J Swaminathan, V Spero, R O'Brien, E Taylor, R Superfine, R AF Osborne, L. D. Cribb, J. Swaminathan, V. Spero, R. O'Brien, E. Taylor, R. Superfine, R. TI High Throughput Passive Rheology Assay for Cancer Cell Mechanics. SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Osborne, L. D.; Cribb, J.; Spero, R.; O'Brien, E.; Superfine, R.] Univ N Carolina, Dept Phys & Astron, Chapel Hill, NC USA. [Swaminathan, V.] NHLBI, Lab Cell & Tissue Morphodynam, Bethesda, MD USA. [Taylor, R.] Univ N Carolina, Dept Comp Sci, Chapel Hill, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 2218 PG 1 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505504250 ER PT J AU Pattabiraman, PP Lih, FB Tomer, KB Rao, V AF Pattabiraman, P. P. Lih, F. B. Tomer, K. B. Rao, V. TI The role of Calcium-Independent Phospholipase A2 in homeostasis of aqueous humor drainage: Ca+2 sensitization of trabecular meshwork contraction. SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Pattabiraman, P. P.; Rao, V.] Duke Univ, Dept Ophthalmol, Durham, NC USA. [Lih, F. B.; Tomer, K. B.] NIEHS, Mass Spect Grp, Durham, NC USA. [Rao, V.] Duke Univ, Dept Pharmacol, Durham, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 627 PG 1 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505501180 ER PT J AU Plotnikov, SV Pasapera, A Sabass, B Schwarz, U Waterman, CM AF Plotnikov, S. V. Pasapera, A. Sabass, B. Schwarz, U. Waterman, C. M. TI Oscillatory Coupling between the Extracellular Matrix and the Actin Cytoskeleton is Essential for Cell Mechanosensing and Durotaxis SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Plotnikov, S. V.; Pasapera, A.; Waterman, C. M.] NHLBI, Bethesda, MD 20892 USA. [Sabass, B.; Schwarz, U.] Univ Heidelberg, D-6900 Heidelberg, Germany. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 1531 PG 2 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505503118 ER PT J AU Renvoise, B Stadler, J Singh, R Bakowska, J Blackstone, C AF Renvoise, B. Stadler, J. Singh, R. Bakowska, J. Blackstone, C. TI Spg20-/- mice reveal multimodal functions for Troyer syndrome protein spartin in lipid droplet maintenance, cytokinesis, and BMP signaling SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Renvoise, B.; Stadler, J.; Singh, R.; Blackstone, C.] NINDS, Cellular Neurol Sect, NIH, Bethesda, MD 20892 USA. [Bakowska, J.] Loyola Univ Chicago, Dept Pharmacol, Maywood, IL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 118 PG 1 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505500119 ER PT J AU Rivera-Dictter, A Bustamante, H Munoz, V Cavieres, V Mardones, GA Bonifacino, JS Burgos, PV AF Rivera-Dictter, A. Bustamante, H. Munoz, V. Cavieres, V. Mardones, G. A. Bonifacino, J. S. Burgos, P. V. TI Turnover of amyloid precursor protein carboxy terminal fragment beta (C99) in lysosomal compartments. SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Rivera-Dictter, A.; Bustamante, H.; Munoz, V.; Cavieres, V.; Mardones, G. A.; Burgos, P. V.] Univ Austral Chile, Sch Med, Valdivia, Chile. [Bonifacino, J. S.] NICHHD, CBMP, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 1988 PG 2 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505504019 ER PT J AU Rodgers, L Anderson, J Fanning, A AF Rodgers, L. Anderson, J. Fanning, A. TI Multiple binding domains within the ZO-1 scaffolding protein are required for proper junction assembly and function SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Rodgers, L.; Fanning, A.] Univ N Carolina, Chapel Hill, NC USA. [Anderson, J.] NHLBI, NIH, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 383 PG 2 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505500382 ER PT J AU Ross, BH Corales, EA Lin, Y Hurley, JH Bonifacino, JS Burgos, PV Mardones, GA AF Ross, B. H. Corales, E. A. Lin, Y. Hurley, J. H. Bonifacino, J. S. Burgos, P. V. Mardones, G. A. TI Structural and functional characterization of cargo-binding sites of the mu 4-subunit of adaptor protein complex 4. SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Ross, B. H.; Corales, E. A.; Lin, Y.; Burgos, P. V.; Mardones, G. A.] Univ Austral Chile, Sch Med, Valdivia, Chile. [Hurley, J. H.] NIDDK, LMB, NIH, Bethesda, MD USA. [Bonifacino, J. S.] NICHHD, CBMP, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 1983 PG 1 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505504014 ER PT J AU Subach, O Patterson, G Verkhusha, V AF Subach, O. Patterson, G. Verkhusha, V. TI Photoswitchable orange fluorescent protein forms novel far-red chromophore after irradiation with visible light SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Subach, O.; Verkhusha, V.] Albert Einstein Coll Med, Dept Anat & Struct Biol, Bronx, NY 10467 USA. [Subach, O.; Verkhusha, V.] Albert Einstein Coll Med, Gruss Lipper Biophoton Ctr, Bronx, NY 10467 USA. [Patterson, G.] Natl Inst Biomed Imaging & Bioengn, Biophoton Sect, NIH, Bethesda, MD USA. RI Subach, Oksana (Gritsenko)/K-7086-2014 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 1143 PG 2 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505502258 ER PT J AU Swaminathan, V Mythreye, K Guilluy, C O'Brien, E Blobe, GC Burridge, K Superfine, R AF Swaminathan, V. Mythreye, K. Guilluy, C. O'Brien, E. Blobe, G. C. Burridge, K. Superfine, R. TI Role of stiffness and force response in integrin mediated signaling and metastasis. SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Swaminathan, V.] NHLBI, NIH, Bethesda, MD 20892 USA. [Mythreye, K.] Duke Univ, Dept Med, Durham, NC 27706 USA. [Guilluy, C.; O'Brien, E.; Burridge, K.; Superfine, R.] Univ N Carolina, Chapel Hill, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 1874 PG 1 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505503454 ER PT J AU Szyk, A Deaconescu, A Piszczek, G Roll-Mecak, A AF Szyk, A. Deaconescu, A. Piszczek, G. Roll-Mecak, A. TI The crystal structure of tubulin tyrosine ligase offers insight into tubulin recognition SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Szyk, A.; Roll-Mecak, A.] NINDS, Cell Biol & Biophys Unit, NIH, Bethesda, MD 20892 USA. [Piszczek, G.; Roll-Mecak, A.] NHLBI, NIH, Bethesda, MD 20892 USA. [Deaconescu, A.] Brandeis Univ, Waltham, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 99 PG 1 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505500100 ER PT J AU Thievessen, I Berlemont, S Plotnikov, S Zemljic-Harpf, A Ross, R Danuser, G Waterman, C AF Thievessen, I. Berlemont, S. Plotnikov, S. Zemljic-Harpf, A. Ross, R. Danuser, G. Waterman, C. TI Differential Requirement for Vinculin in Actin Engagement and Growth of Focal Adhesions SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Thievessen, I.; Plotnikov, S.; Waterman, C.] NHLBI, Cell Biol & Physiol Ctr, Lab Cell & Tissue Morphodynam, NIH, Bethesda, MD 20892 USA. [Berlemont, S.; Danuser, G.] Harvard Univ, Sch Med, Dept Cell Biol, Lab Computat Cell Biol, Cambridge, MA 02138 USA. [Zemljic-Harpf, A.; Ross, R.] Univ Calif San Diego, Sch Med, Dept Med, Div Cardiol, La Jolla, CA 92093 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 1577 PG 1 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505503162 ER PT J AU Thievessen, I Fakhri, N McIsaac, S Gao, L Chen, BC Betzig, E Oldenbourg, R Waterman, CM AF Thievessen, I. Fakhri, N. McIsaac, S. Gao, L. Chen, B-C. Betzig, E. Oldenbourg, R. Waterman, C. M. TI Vinculin is required for cell polarization, migration and extracellular matrix remodeling in three-dimensional collagen matrices SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Thievessen, I.; Waterman, C. M.] NHLBI, Lab Cell & Tissue Morphodynam, NIH, Bethesda, MD 20892 USA. [Fakhri, N.] Univ Gottingen, Fak Phys, Inst Phys 3, Gottingen, Germany. [McIsaac, S.] Princeton Univ, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA. NR 0 TC 0 Z9 0 U1 1 U2 5 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 1525 PG 1 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505503112 ER PT J AU Weiger, M Vedhem, V Stuelten, C Shou, K Herrera, M Losert, W Parent, C AF Weiger, M. Vedhem, V. Stuelten, C. Shou, K. Herrera, M. Losert, W. Parent, C. TI Distinct effects of EGF and LPA on cell migration dynamics during breast cancer progression. SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Weiger, M.; Vedhem, V.; Stuelten, C.; Shou, K.; Parent, C.] NCI, Mol & Cellular Biol Lab, NIH, Bethesda, MD 20892 USA. [Herrera, M.; Losert, W.] Univ Maryland, Dept Phys, College Pk, MD 20742 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 1884 PG 2 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505503464 ER PT J AU Witkin, K Chong, Y Shao, S Webster, M Lahiri, S Lee, B Koh, J Prinz, W Andrews, B Cohen-Fix, O AF Witkin, K. Chong, Y. Shao, S. Webster, M. Lahiri, S. Lee, B. Koh, J. Prinz, W. Andrews, B. Cohen-Fix, O. TI The budding yeast nuclear envelope adjacent to the nucleolus serves as a "membrane sink" during mitotic delay SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Witkin, K.; Shao, S.; Webster, M.; Lahiri, S.; Lee, B.; Prinz, W.; Cohen-Fix, O.] NIDDK, NIH, Bethesda, MD USA. [Chong, Y.; Koh, J.; Andrews, B.] Univ Toronto, Toronto, ON M5S 1A1, Canada. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 145 PG 2 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505500146 ER PT J AU Zhang, Y Conti, M Malide, D Dong, F Wang, A Shmist, Y Liu, C Zerfas, P Daniels, M Chan, CC Kozin, E Kachar, B Kelley, M Kopp, J Adelstein, RS AF Zhang, Y. Conti, M. Malide, D. Dong, F. Wang, A. Shmist, Y. Liu, C. Zerfas, P. Daniels, M. Chan, C-C. Kozin, E. Kachar, B. Kelley, M. Kopp, J. Adelstein, R. S. TI Mutations in the Motor and Rod Domains of Murine Nonmuscle Myosin II-A Cause Similar Defects and Mimic Human MYH9-Related Disease SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB) CY DEC 03-07, 2011 CL Denver, CO SP Amer Soc Cell Biol (ASCB) C1 [Zhang, Y.; Conti, M.; Malide, D.; Wang, A.; Shmist, Y.; Liu, C.; Daniels, M.; Adelstein, R. S.] NHLBI, NIH, Bethesda, MD 20892 USA. [Dong, F.; Kelley, M.] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA. [Daniels, M.] NIH, Off Res Serv, Div Vet Resources, Bethesda, MD 20892 USA. [Chan, C-C.] NEI, NIH, Bethesda, MD 20892 USA. [Kozin, E.; Kachar, B.] NIDCD, NIH, Bethesda, MD USA. [Kelley, M.] Durham Vet Affairs Med Ctr, Med Serv, Durham, NC USA. [Kopp, J.] NIDDK, NIH, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PY 2011 VL 22 MA 295 PG 2 WC Cell Biology SC Cell Biology GA 961YM UT WOS:000305505500294 ER PT B AU Long, LR Antani, S Thoma, GR Deserno, TM AF Long, L. Rodney Antani, Sameer Thoma, George R. Deserno, Thomas M. BA Tan, J BF Tan, J TI Content-Based Image Retrieval for Advancing Medical Diagnostics, Treatment and Education SO NEW TECHNOLOGIES FOR ADVANCING HEALTHCARE AND CLINICAL PRACTICES LA English DT Article; Book Chapter ID INFORMATION-SOCIETY; HEALTH-CARE; SYSTEMS; FUTURE; ANNOTATION AB Content-Based Image Retrieval (CBIR) technology has been proposed to benefit not only the management of increasingly large medical image collections, but also to aid clinical care, biomedical research, and education. Based on a literature review, we conclude that there is widespread enthusiasm for CBIR in the engineering research community, but the application of this technology to solve practical medical problems is a goal yet to be realized. Furthermore, we highlight "gaps" between desired CBIR system functionality and what has been achieved to date, present a comparative analysis of four state-of-the-art CBIR implementations using the gap approach for illustration, and suggest that high-priority gaps to be overcome lie in CBIR interfaces and functionality that better serve the clinical and biomedical research communities. C1 [Long, L. Rodney; Antani, Sameer] Natl Lib Med, Commun Engn Branch, Bethesda, MD 20894 USA. [Deserno, Thomas M.] Rhein Westfal TH Aachen, Sch Med, Div Med Image Proc, Aachen, Germany. RP Long, LR (reprint author), Natl Lib Med, Commun Engn Branch, Bethesda, MD 20894 USA. NR 28 TC 2 Z9 2 U1 0 U2 0 PU IGI GLOBAL PI HERSEY PA 701 E CHOCOLATE AVE, STE 200, HERSEY, PA 17033-1240 USA BN 978-1-60960-781-4; 978-1-60960-780-7 PY 2011 BP 1 EP 17 DI 10.4018/978-1-60960-780-7.ch001 D2 10.4018/978-1-60960-780-7 PG 17 WC Medical Informatics SC Medical Informatics GA BZX78 UT WOS:000303259600002 ER PT B AU Muller, H Kalpathy-Cramer, J AF Mueller, Henning Kalpathy-Cramer, Jayashree BA Tan, J BF Tan, J TI Putting the Content Into Context: Features and Gaps in Image Retrieval SO NEW TECHNOLOGIES FOR ADVANCING HEALTHCARE AND CLINICAL PRACTICES LA English DT Article; Book Chapter ID INFORMATION; SYSTEMS; CAPACITY; STORAGE; FUTURE AB Digital management of medical images is becoming increasingly important as the number of images being created in medical settings everyday is growing rapidly. Content-based image retrieval or techniques based on the query-by-example paradigm have been studied extensively in computer vision. However, the global, low level visual features automatically extracted by these algorithms do not always correspond to high level concepts that a user has in his mind for searching. The role of image retrieval in diagnostic medicine can be quite complex, making it difficult for the user to express his/her information needs appropriately. Image retrieval in medicine needs to evolve from purely visual retrieval to a more holistic, case-based approach that incorporates various multimedia data sources. These include multiple images, free text, structured data, as well as external knowledge sources and ontologies. C1 [Mueller, Henning] Univ & Hosp Geneva, Med Informat Serv, MedGIFT Project Med Image Retrieval, Geneva, Switzerland. [Mueller, Henning] Univ Appl Sci, Zurich, Switzerland. [Kalpathy-Cramer, Jayashree] Oregon Hlth & Sci Univ, Natl Lib Med, Dept Med Informat & Clin Epidemiol, Portland, OR 97201 USA. [Kalpathy-Cramer, Jayashree] Oregon Hlth & Sci Univ, Dept Med Informat, Portland, OR 97201 USA. RP Muller, H (reprint author), Univ & Hosp Geneva, Med Informat Serv, MedGIFT Project Med Image Retrieval, Geneva, Switzerland. NR 39 TC 1 Z9 1 U1 0 U2 0 PU IGI GLOBAL PI HERSEY PA 701 E CHOCOLATE AVE, STE 200, HERSEY, PA 17033-1240 USA BN 978-1-60960-781-4; 978-1-60960-780-7 PY 2011 BP 105 EP 115 DI 10.4018/978-1-60960-780-7.ch006 D2 10.4018/978-1-60960-780-7 PG 11 WC Medical Informatics SC Medical Informatics GA BZX78 UT WOS:000303259600007 ER PT B AU Pender, NP Koroshetz, WJ AF Pender, Niall P. Koroshetz, Walter J. BE Hardiman, O Doherty, CP TI Huntington's Disease SO NEURODEGENERATIVE DISORDERS: A CLINICAL GUIDE LA English DT Article; Book Chapter DE Huntington's disease; Chorea; Huntingtin (protein); GAG repeat; Neurodegeneration; Neurogenetic (disorder); Presymptomatic genetic testing; Motor control; Neuropsychiatric; Cognitive disorder; Behavioral difficulties ID PHAROS; RISK AB Huntington's disease (HD) is an autosomal dominant neurodegenerative brain disorder. The mutation was identified in 1993 as an expanded CAG repeat that codes for an abnormally high number of glutamines in the huntingtin protein. At present, there is no known treatment to slow the pace of neurodegeneration, which generally leads to death over a 20-year period after clinical diagnosis. The clinical manifestations of the disease vary widely but they generally include dysfunction in cognition, mood, voluntary motor control, and most patients have the signature finding of chorea. C1 [Koroshetz, Walter J.] NIH, Neurol Disorders & Stroke Inst, Bethesda, MD 20892 USA. [Pender, Niall P.] Beaumont Hosp, Dept Psychol, Dublin 9, Ireland. RP Koroshetz, WJ (reprint author), NIH, Neurol Disorders & Stroke Inst, Bldg 10, Bethesda, MD 20892 USA. EM koroshetzw@mail.nih.gov NR 21 TC 0 Z9 0 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-84996-010-6 PY 2011 BP 167 EP 179 DI 10.1007/978-1-84996-011-3_8 D2 10.1007/978-1-84996-011-3 PG 13 WC Primary Health Care; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA BZW79 UT WOS:000303171300008 ER PT J AU Felblinger, DM AF Felblinger, Dianne M. BE LanganFox, J Cooper, CL TI Incivility and bullying in the nursing workplace SO HANDBOOK OF STRESS IN THE OCCUPATIONS SE New Horizons in Management LA English DT Article; Book Chapter ID WORK-ENVIRONMENT; NURSES; SYMPTOMS; VICTIMS; STRESS; STAFF; PRODUCTIVITY; CONSEQUENCES; OUTCOMES; TRAUMA C1 Univ Cincinnati, Natl Inst Alcohol Abuse & Alcoholism, Cincinnati, OH 45221 USA. RP Felblinger, DM (reprint author), Univ Cincinnati, Natl Inst Alcohol Abuse & Alcoholism, Cincinnati, OH 45221 USA. NR 64 TC 1 Z9 1 U1 1 U2 1 PU EDWARD ELGAR PUBLISHING LTD PI CHELTENHAM PA GLENSANDA HOUSE, MONTPELLIER PARADE, CHELTENHAM GL50 1UA, GLOS, ENGLAND BN 978-0-85793-114-6 J9 NEW HORIZ MANAG PY 2011 BP 5 EP 15 PG 11 WC Psychology, Applied; Management SC Psychology; Business & Economics GA BYJ57 UT WOS:000299045400003 ER PT S AU Grossman, JH McNeil, SE AF Grossman, Jennifer H. McNeil, Scott E. BE Alexiou, C TI Preclinical Efficacy and Toxicity Testing of Engineered Nanomaterials SO NANOMEDICINE - BASIC AND CLINICAL APPLICATIONS IN DIAGNOSTICS AND THERAPY SE Else Kroner-Fresenius Symposia LA English DT Proceedings Paper CT 2nd Else Kroner-Fresenius Symposium CY SEP 03-05, 2010 CL Erlangen, GERMANY SP Else Kroner Fresenius Stiftung ID STERICALLY STABILIZED LIPOSOMES; PHASE-I; NANOPARTICLE INTERACTION; THERAPEUTIC-EFFICACY; BIODISTRIBUTION; VITRO; VIVO AB As engineered nanomaterials (ENMs) - man-made products between 1 and approximately 100 nm in size - are increasingly used in consumer, industrial, and medical products, it becomes more important than ever to understand ENM interactions with biology and the environment. Recent results show that seemingly small changes in ENM chemistry can cause dramatic differences in potency and safety, making thorough characterization critical for the manufacture and use of ENMs. Characterization is especially important for ENMs used in medical products. In the pharmaceutical industry, ENMs are being used to reformulate drugs to 'engineer out' disqualifying characteristics such as poor solubility and/or liver and spleen accumulation. In contrast to the development of new molecular entities, using ENMs to reformulate and salvage previously discontinued drugs greatly reduces the time, risk, and investment required for new drug development. Copyright (C) 2011 S. Karger AG, Basel C1 [McNeil, Scott E.] Natl Canc Inst Frederick Attn, SAIC Frederick Inc, NCI Frederick, Nanotechnol Characterizat Lab, POB B,Bldg 469,1050 Boyles St, Ft Detrick, MD 21702 USA. RP McNeil, SE (reprint author), Natl Canc Inst Frederick Attn, SAIC Frederick Inc, NCI Frederick, Nanotechnol Characterizat Lab, POB B,Bldg 469,1050 Boyles St, Ft Detrick, MD 21702 USA. EM ncl@mail.nih.gov FU National Cancer Institute; National Institutes of Health [HHSN261200800001E] FX This project has been funded in whole or in part with federal funds from the National Cancer Institute, National Institutes of Health, under contract HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government NR 23 TC 0 Z9 0 U1 0 U2 1 PU KARGER PI BASEL PA POSTFACH, CH-4009 BASEL, SWITZERLAND SN 1663-0114 BN 978-3-8055-9818-7 J9 ELSE KRONER FRESEN S PY 2011 VL 2 BP 71 EP + PG 2 WC Biotechnology & Applied Microbiology; Nanoscience & Nanotechnology; Medicine, Research & Experimental SC Biotechnology & Applied Microbiology; Science & Technology - Other Topics; Research & Experimental Medicine GA BAG41 UT WOS:000304074300006 ER PT J AU Le, SY Shapiro, BA AF Le, Shu-Yun Shapiro, Bruce A. TI Data mining of functional RNA structures in genomic sequences SO WILEY INTERDISCIPLINARY REVIEWS-DATA MINING AND KNOWLEDGE DISCOVERY LA English DT Article ID RIBOSOME ENTRY SITES; SECONDARY STRUCTURE; MESSENGER-RNA; STRUCTURE PREDICTION; INTERNAL INITIATION; TRANSLATION; MOLECULES; REGIONS; BINDING; PROTEIN AB The normal functions of genomes depend on the precise expression of messenger RNAs and noncoding RNAs (ncRNAs) such as transfer RNAs and microRNAs in eukaryotes. These ncRNAs and functional RNA structures (FRSs) act as regulators or response elements for cellular factors and participate in transcription, post-transcriptional processing, and translation. Knowledge discovery of these FRSs in huge DNA/RNA sequence databases is a very important step to reach our goal of going from genomic sequence data to biological knowledge for understanding RNA-based regulation. Analyses of a large number of FRSs have indicated that the FRS can be well characterized by some quantitative measures such as significance and well-ordered scores of the local segment. Various data mining tools have been developed and successfully applied to FRS discovery in genomic sequence databases. Here, we summarize our efforts in the computational discovery of structured features of ncRNAs and FRSs within complex genomes by EDscan and SigED. (C) 2011 John Wiley & Sons, Inc. WIREs DataMining Knowl Discov 2011 1 88-95 DOI: 10.1002/widm.13 C1 [Le, Shu-Yun; Shapiro, Bruce A.] NCI, Ctr Canc Res Nanobiol Program, NCI Ctr Canc Res, Frederick, MD 21701 USA. RP Le, SY (reprint author), NCI, Ctr Canc Res Nanobiol Program, NCI Ctr Canc Res, Frederick, MD 21701 USA. EM shuyun@ncifcrf.gov NR 32 TC 1 Z9 1 U1 0 U2 4 PU WILEY PERIODICALS, INC PI SAN FRANCISCO PA ONE MONTGOMERY ST, SUITE 1200, SAN FRANCISCO, CA 94104 USA SN 1942-4787 J9 WIRES DATA MIN KNOWL JI Wiley Interdiscip. Rev.-Data Mining Knowl. Discov. PD JAN-FEB PY 2011 VL 1 IS 1 BP 88 EP 95 DI 10.1002/widm.13 PG 8 WC Computer Science, Artificial Intelligence; Computer Science, Theory & Methods SC Computer Science GA 945FE UT WOS:000304257400010 ER PT J AU Moore, JW Turner, DC Corlett, PR Arana, FS Morgan, HL Absalom, AR Adapa, R de Wit, S Everitt, JC Gardner, JM Pigott, JS Haggard, P Fletcher, PC AF Moore, James W. Turner, Danielle C. Corlett, Philip R. Arana, Fernando S. Morgan, Hannah L. Absalom, Antony R. Adapa, Ram de Wit, Sanne Everitt, Jessica C. Gardner, Jenny M. Pigott, Jennifer S. Haggard, Patrick Fletcher, Paul C. TI Ketamine administration in healthy volunteers reproduces aberrant agency experiences associated with schizophrenia SO COGNITIVE NEUROPSYCHIATRY LA English DT Article DE Action-outcome binding; Ketamine; Schizophrenia; Sense of agency; Volition; Voluntary action ID EMISSION-TOMOGRAPHY PET; CONSCIOUS AWARENESS; PREDICTION-ERROR; VOLUNTARY ACTION; BODY-OWNERSHIP; PSYCHOSIS; SYMPTOMS; INTENTION; DELUSIONS; MEMORY AB Introduction. Aberrant experience of agency is characteristic of schizophrenia. An understanding of the neurobiological basis of such experience is therefore of considerable importance for developing successful models of the disease. We aimed to characterise the effects of ketamine, a drug model for psychosis, on sense of agency (SoA). SoA is associated with a subjective compression of the temporal interval between an action and its effects: This is known as "intentional binding''. This action-effect binding provides an indirect measure of SoA. Previous research has found that the magnitude of binding is exaggerated in patients with schizophrenia. We therefore investigated whether ketamine administration to otherwise healthy adults induced a similar pattern of binding. Methods. 14 right-handed healthy participants (8 female; mean age 22.4 years) were given low-dose ketamine (100 ng/mL plasma) and completed the binding task. They also underwent structured clinical interviews. Results. Ketamine mimicked the performance of schizophrenia patients on the intentional binding task, significantly increasing binding relative to placebo. The size of this effect also correlated with aberrant bodily experiences engendered by the drug. Conclusions. These data suggest that ketamine may be able to mimic certain aberrant agency experiences that characterise schizophrenia. The link to individual changes in bodily experience suggests that the fundamental change produced by the drug has wider consequences in terms of individuals' experiences of their bodies and movements. C1 [Moore, James W.; Corlett, Philip R.; Arana, Fernando S.; Morgan, Hannah L.; de Wit, Sanne; Everitt, Jessica C.; Fletcher, Paul C.] Univ Cambridge, Dept Psychiat, Brain Mapping Unit, Cambridge CB2 3EB, England. [Turner, Danielle C.] Univ Cambridge, St Johns Coll, Cambridge, England. [Arana, Fernando S.] NIMH, Clin Brain Disorders Branch, Genes Cognit & Psychosis Program, NIH, Bethesda, MD 20892 USA. [Absalom, Antony R.] Univ Groningen, Univ Med Ctr Groningen, Dept Anesthesiol, Groningen, Netherlands. [Absalom, Antony R.; Adapa, Ram] Addenbrookes Hosp, Univ Div Anaesthesia, Cambridge, England. [de Wit, Sanne] Univ Amsterdam, Amsterdam Ctr Study Adapt Control Brain & Behav A, Dept Psychol, NL-1012 WX Amsterdam, Netherlands. [Gardner, Jenny M.] Univ Cambridge, Addenbrookes Hosp, Sch Clin Med, Cambridge CB2 2QQ, England. [Pigott, Jennifer S.] UCL, Sch Med, London W1N 8AA, England. [Haggard, Patrick] UCL, Inst Cognit Neurosci, London, England. [Corlett, Philip R.] Yale Univ, Sch Med, Dept Psychiat, Connecticut Mental Hlth Ctr,Abraham Ribicoff Res, New Haven, CT USA. RP Moore, JW (reprint author), Univ Cambridge, Dept Psychiat, Brain Mapping Unit, Downing Site, Cambridge CB2 3EB, England. EM jm697@cam.ac.uk RI Adapa, Ram/D-7925-2012; OI Adapa, Ram/0000-0002-9845-8532; Corlett, Philip/0000-0002-5368-1992; Absalom, Anthony/0000-0001-7563-9157 FU Wellcome Trust; Bernard Wolfe Health Neuroscience fund; Medical Research Council FX This work was supported by the Wellcome Trust and the Bernard Wolfe Health Neuroscience fund. It was carried out at the Wellcome Trust Clinical Research Facility (Addenbrooke's Hospital, Cambridge) and within the Behavioural and Clinical Neurosciences Institute, jointly supported by the Medical Research Council and the Wellcome Trust. JM and PCF had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. NR 58 TC 13 Z9 14 U1 2 U2 13 PU PSYCHOLOGY PRESS PI HOVE PA 27 CHURCH RD, HOVE BN3 2FA, EAST SUSSEX, ENGLAND SN 1354-6805 J9 COGN NEUROPSYCHIATRY JI Cogn. Neuropsychiatry PY 2011 VL 16 IS 4 BP 364 EP 381 DI 10.1080/13546805.2010.546074 PG 18 WC Psychiatry SC Psychiatry GA 945DL UT WOS:000304252900005 PM 21302161 ER PT S AU Orru, CD Caughey, B AF Orru, Christina D. Caughey, Byron BE Tatzelt, J TI Prion Seeded Conversion and Amplification Assays SO PRION PROTEINS SE Topics in Current Chemistry LA English DT Review; Book Chapter DE Prion composition; PMCA; QuIC; ASA; Transmissible; Spongiform; Ecephalopathies ID MISFOLDING CYCLIC AMPLIFICATION; CREUTZFELDT-JAKOB-DISEASE; IN-VITRO AMPLIFICATION; PROTEASE-RESISTANT FORMS; CHRONIC WASTING DISEASE; CELL-FREE FORMATION; PRESYMPTOMATIC DETECTION; SENSITIVE DETECTION; INFECTIOUS PRIONS; MAMMALIAN PRIONS AB The conversion of the normal prion protein (PrPC) into its misfolded, aggregation-prone and infectious (prion) isoform is central to the progression of transmissible spongiform encephalopathies (TSEs) or prion diseases. Since the initial development of a cell free PrP conversion reaction, striking progress has been made in the development of much more continuous prion-induced conversion and amplification reactions. These studies have provided major insights into the molecular underpinnings of prion propagation and enabled the development of ultra-sensitive tests for prions and prion disease diagnosis. This chapter will provide an overview of such reactions and the practical and fundamental consequences of their development. C1 [Orru, Christina D.; Caughey, Byron] NIAID, Persistent Viral Dis Lab, Rocky Mt Labs, NIH, Hamilton, MT 59840 USA. RP Caughey, B (reprint author), NIAID, Persistent Viral Dis Lab, Rocky Mt Labs, NIH, Hamilton, MT 59840 USA. EM bcaughey@nih.gov NR 63 TC 10 Z9 10 U1 0 U2 10 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0340-1022 BN 978-3-642-24066-9 J9 TOP CURR CHEM JI Top. Curr. Chem. PY 2011 VL 305 BP 121 EP 133 DI 10.1007/128_2011_184 D2 10.1007/978-3-642-24067-6 PG 13 WC Chemistry, Multidisciplinary SC Chemistry GA BZG42 UT WOS:000301512800006 PM 21678135 ER PT J AU Ramus, SJ Kartsonaki, C Gayther, SA Pharoah, PDP Sinilnikova, OM Beesley, J Chen, XQ McGuffog, L Healey, S Couch, FJ Wang, XS Fredericksen, Z Peterlongo, P Manoukian, S Peissel, B Zaffaroni, D Roversi, G Barile, M Viel, A Allavena, A Ottini, L Papi, L Gismondi, V Capra, F Radice, P Greene, MH Mai, PL Andrulis, IL Glendon, G Ozcelik, H Thomassen, M Gerdes, AM Kruse, TA Cruger, D Jensen, UB Caligo, MA Olsson, H Kristoffersson, U Lindblom, A Arver, B Karlsson, P Askmalm, MS Borg, A Neuhausen, SL Ding, YC Nathanson, KL Domchek, SM Jakubowska, A Lubinski, J Huzarski, T Byrski, T Gronwald, J Gorski, B Cybulski, C Debniak, T Osorio, A Duran, M Tejada, MI Benitez, J Hamann, U Rookus, MA Verhoef, S Tilanus-Linthorst, MA Vreeswijk, MP Bodmer, D Ausems, MGEM van Os, TA Asperen, CJ Blok, MJ Meijers-Heijboer, HEJ Peock, S Cook, M Oliver, C Frost, D Dunning, AM Evans, DG Eeles, R Pichert, G Cole, T Hodgson, S Brewer, C Morrison, PJ Porteous, M Kennedy, MJ Rogers, MT Side, LE Donaldson, A Gregory, H Godwin, A Stoppa-Lyonnet, D Moncoutier, V Castera, L Mazoyer, S Barjhoux, L Bonadona, V Leroux, D Faivre, L Lidereau, R Nogues, C Bignon, YJ Prieur, F Collonge-Rame, MA Venat-Bouvet, L Fert-Ferrer, S Miron, A Buys, SS Hopper, JL Daly, MB John, EM Terry, MB Goldgar, D Hansen, TVO Jonson, L Ejlertsen, B Agnarsson, BA Offit, K Kirchhoff, T Vijai, J Dutra-Clarke, AVC Przybylo, JA Montagna, M Casella, C Imyanitov, EN Janavicius, R Blanco, I Lazaro, C Moysich, KB Karlan, BY Gross, J Beattie, MS Schmutzler, R Wappenschmidt, B Meindl, A Ruehl, I Fiebig, B Sutter, C Arnold, N Deissler, H Varon-Mateeva, R Kast, K Niederacher, D Gadzicki, D Caldes, T de la Hoya, M Nevanlinna, H Aittomaki, K Simard, J Soucy, P Spurdle, AB Holland, H Chenevix-Trench, G Easton, DF Antoniou, AC AF Ramus, Susan J. Kartsonaki, Christiana Gayther, Simon A. Pharoah, Paul D. P. Sinilnikova, Olga M. Beesley, Jonathan Chen, Xiaoqing McGuffog, Lesley Healey, Sue Couch, Fergus J. Wang, Xianshu Fredericksen, Zachary Peterlongo, Paolo Manoukian, Siranoush Peissel, Bernard Zaffaroni, Daniela Roversi, Gaia Barile, Monica Viel, Alessandra Allavena, Anna Ottini, Laura Papi, Laura Gismondi, Viviana Capra, Fabio Radice, Paolo Greene, Mark H. Mai, Phuong L. Andrulis, Irene L. Glendon, Gord Ozcelik, Hilmi Thomassen, Mads Gerdes, Anne-Marie Kruse, Torben A. Cruger, Dorthe Jensen, Uffe Birk Caligo, Maria Adelaide Olsson, Hakan Kristoffersson, Ulf Lindblom, Annika Arver, Brita Karlsson, Per Askmalm, Marie Stenmark Borg, Ake Neuhausen, Susan L. Ding, Yuan Chun Nathanson, Katherine L. Domchek, Susan M. Jakubowska, Anna Lubinski, Jan Huzarski, Tomasz Byrski, Tomasz Gronwald, Jacek Gorski, Bohdan Cybulski, Cezary Debniak, Tadeusz Osorio, Ana Duran, Mercedes Tejada, Maria-Isabel Benitez, Javier Hamann, Ute Rookus, Matti A. Verhoef, Senno Tilanus-Linthorst, Madeleine A. Vreeswijk, Maaike P. Bodmer, Danielle Ausems, Margreet G. E. M. van Os, Theo A. Asperen, Christi J. Blok, Marinus J. Meijers-Heijboer, Hanne E. J. Peock, Susan Cook, Margaret Oliver, Clare Frost, Debra Dunning, Alison M. Evans, D. Gareth Eeles, Ros Pichert, Gabriella Cole, Trevor Hodgson, Shirley Brewer, Carole Morrison, Patrick J. Porteous, Mary Kennedy, M. John Rogers, Mark T. Side, Lucy E. Donaldson, Alan Gregory, Helen Godwin, Andrew Stoppa-Lyonnet, Dominique Moncoutier, Virginie Castera, Laurent Mazoyer, Sylvie Barjhoux, Laure Bonadona, Valerie Leroux, Dominique Faivre, Laurence Lidereau, Rosette Nogues, Catherine Bignon, Yves-Jean Prieur, Fabienne Collonge-Rame, Marie-Agnes Venat-Bouvet, Laurence Fert-Ferrer, Sandra Miron, Alex Buys, Saundra S. Hopper, John L. Daly, Mary B. John, Esther M. Terry, Mary Beth Goldgar, David Hansen, Thomas V. O. Jonson, Lars Ejlertsen, Bent Agnarsson, Bjarni A. Offit, Kenneth Kirchhoff, Tomas Vijai, Joseph Dutra-Clarke, Ana V. C. Przybylo, Jennifer A. Montagna, Marco Casella, Cinzia Imyanitov, Evgeny N. Janavicius, Ramunas Blanco, Ignacio Lazaro, Conxi Moysich, Kirsten B. Karlan, Beth Y. Gross, Jenny Beattie, Mary S. Schmutzler, Rita Wappenschmidt, Barbara Meindl, Alfons Ruehl, Ina Fiebig, Britta Sutter, Christian Arnold, Norbert Deissler, Helmut Varon-Mateeva, Raymonda Kast, Karin Niederacher, Dieter Gadzicki, Dorothea Caldes, Trinidad de la Hoya, Miguel Nevanlinna, Heli Aittomaeki, Kristiina Simard, Jacques Soucy, Penny Spurdle, Amanda B. Holland, Helene Chenevix-Trench, Georgia Easton, Douglas F. Antoniou, Antonis C. CA OCGN HEBON EMBRACE GEMO Study Collaborators BCFR KConFab Investigators Consortium Investigators Modifiers TI Genetic Variation at 9p22.2 and Ovarian Cancer Risk for BRCA1 and BRCA2 Mutation Carriers SO JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE LA English DT Article ID GENOME-WIDE ASSOCIATION; BREAST-CANCER; SUSCEPTIBILITY LOCI; GERMLINE MUTATIONS; ALLELES; IDENTIFICATION; BASONUCLIN-2; POPULATION; PROTEINS; FAMILIES AB Background Germline mutations in the BRCA1 and BRCA2 genes are associated with increased risks of breast and ovarian cancers. Although several common variants have been associated with breast cancer susceptibility in mutation carriers, none have been associated with ovarian cancer susceptibility. A genome-wide association study recently identified an association between the rare allele of the single-nucleotide polymorphism (SNP) rs3814113 (ie, the C allele) at 9p22.2 and decreased risk of ovarian cancer for women in the general population. We evaluated the association of this SNP with ovarian cancer risk among BRCA1 or BRCA2 mutation carriers by use of data from the Consortium of Investigators of Modifiers of BRCA1/2. Methods We genotyped rs3814113 in 10 029 BRCA1 mutation carriers and 5837 BRCA2 mutation carriers. Associations with ovarian and breast cancer were assessed with a retrospective likelihood approach. All statistical tests were two-sided. Results The minor allele of rs3814113 was associated with a reduced risk of ovarian cancer among BRCA1 mutation carriers (per-allele hazard ratio of ovarian cancer = 0.78, 95% confidence interval = 0.72 to 0.85; P = 4.8 x 10(-9)) and BRCA2 mutation carriers (hazard ratio of ovarian cancer = 0.78, 95% confidence interval = 0.67 to 0.90; P = 5.5 x 10(-4)). This SNP was not associated with breast cancer risk among either BRCA1 or BRCA2 mutation carriers. BRCA1 mutation carriers with the TT genotype at SNP rs3814113 were predicted to have an ovarian cancer risk to age 80 years of 48%, and those with the CC genotype were predicted to have a risk of 33%. Conclusion Common genetic variation at the 9p22.2 locus was associated with decreased risk of ovarian cancer for carriers of a BRCA1 or BRCA2 mutation. C1 [Ramus, Susan J.; Gayther, Simon A.] UCL, Dept Gynaecol Oncol, UCL EGA Inst Womens Hlth, London, England. [Kartsonaki, Christiana; McGuffog, Lesley; Peock, Susan; Cook, Margaret; Oliver, Clare; Frost, Debra; Antoniou, Antonis C.] Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England. [Pharoah, Paul D. P.] Univ Cambridge, Strangeways Res Lab, Canc Res United Kingdom Dept Oncol, Cambridge, England. [Pharoah, Paul D. P.] Univ Cambridge, Strangeways Res Lab, Dept Publ Hlth & Primary Care, Cambridge, England. [Sinilnikova, Olga M.] Univ Lyon, Ctr Hosp Univ Lyon, Ctr Leon Berard, Unite Mixte Genet Constitut Canc Frequents, Lyon, France. [Sinilnikova, Olga M.] Univ Lyon, CNRS, Ctr Leon Berard, UMR5201,Equipe Labellisee LIGUE 2008, Lyon, France. [Beesley, Jonathan; Chen, Xiaoqing; Healey, Sue; Spurdle, Amanda B.; Holland, Helene; Chenevix-Trench, Georgia] Queensland Inst Med Res, Brisbane, Qld 4006, Australia. [Couch, Fergus J.; Wang, Xianshu] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA. [Fredericksen, Zachary] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA. [Peterlongo, Paolo; Radice, Paolo] Fdn IRCCS Ist Nazl Tumori INT, Dept Expt Oncol & Mol Med, Unit Genet Susceptibil Canc, Milan, Italy. [Peterlongo, Paolo; Radice, Paolo] Fdn Ist FIRC Oncol Mol, IFOM, Milan, Italy. [Manoukian, Siranoush; Peissel, Bernard; Zaffaroni, Daniela; Roversi, Gaia] Fdn IRCCS Ist Nazl Tumori INT, Dept Prevent & Predict Med, Unit Med Genet, Milan, Italy. [Barile, Monica] IEO, Div Canc Prevent & Genet, Milan, Italy. [Viel, Alessandra] IRCCS, Div Expt Oncol 1, CRO, Aviano, PN, Italy. [Allavena, Anna] Univ Turin, Dept Genet Biol & Biochem, Turin, Italy. [Ottini, Laura] Univ Roma La Sapienza, Dept Expt Med, I-00185 Rome, Italy. [Papi, Laura] Univ Florence, Dept Clin Physiopathol, Med Genet Unit, Florence, Italy. [Gismondi, Viviana] IRCCS Ist Nazl Ric Canc IST, Dept Epidemiol & Prevent, Genoa, Italy. [Capra, Fabio] Cogentech, Consortium Genom Technol, Milan, Italy. [Greene, Mark H.; Mai, Phuong L.] NCI, Div Canc Epidemiol & Genet, Clin Genet Branch, Bethesda, MD 20892 USA. [Andrulis, Irene L.; Glendon, Gord] Ontario Canc Genet Network, Toronto, ON, Canada. [Andrulis, Irene L.; Ozcelik, Hilmi] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada. [Thomassen, Mads; Gerdes, Anne-Marie; Kruse, Torben A.] Odense Univ Hosp, DK-5000 Odense, Denmark. [Gerdes, Anne-Marie] Rigshosp, DK-2100 Copenhagen, Denmark. [Cruger, Dorthe] Vejle Hosp, Vejle, Denmark. [Jensen, Uffe Birk] Aarhus Univ Hosp, DK-8000 Aarhus, Denmark. [Caligo, Maria Adelaide] Univ Hosp Pisa, Dept Oncol, Sect Genet Oncol, Pisa, Italy. [Ozcelik, Hilmi; Borg, Ake] Lund Univ, Dept Oncol, Lund, Sweden. [Kristoffersson, Ulf] Lund Univ, Dept Clin Genet, Lund, Sweden. [Lindblom, Annika] Karolinska Univ Hosp, Dept Clin Genet, Stockholm, Sweden. [Arver, Brita] Karolinska Univ Hosp, Dept Oncol, Stockholm, Sweden. [Karlsson, Per] Sahlgrens Univ Hosp, Dept Oncol, Gothenburg, Sweden. [Askmalm, Marie Stenmark] Linkoping Univ Hosp, Dept Oncol, S-58185 Linkoping, Sweden. [Neuhausen, Susan L.; Ding, Yuan Chun] City Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Duarte, CA USA. [Nathanson, Katherine L.; Domchek, Susan M.] Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA. [Nathanson, Katherine L.; Domchek, Susan M.] Univ Penn, Sch Med, Abramson Canc Ctr, Philadelphia, PA 19104 USA. [Jakubowska, Anna; Lubinski, Jan; Huzarski, Tomasz; Byrski, Tomasz; Gronwald, Jacek; Gorski, Bohdan; Cybulski, Cezary; Debniak, Tadeusz] Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, Szczecin, Poland. Spanish Natl Canc Res Ctr, Human Canc Genet Programme, Human Genet Grp, Madrid, Spain. [Duran, Mercedes] Univ Valladolid, Inst Biol & Mol Genet IBGM UVA, Valladolid, Spain. [Tejada, Maria-Isabel] Cruces Hosp Barakaldo, Mol Genet Lab, Dept Biochem, Bizkaia, Spain. [Benitez, Javier] Spanish Natl Canc Res Ctr, Human Canc Genet Programme, Human Genet Grp, Madrid, Spain. [Benitez, Javier] Spanish Natl Canc Res Ctr, Human Canc Genet Programme, Genotyping Unit, Madrid, Spain. [Hamann, Ute] Deutsch Krebsforschungszentrum DKFZ, Heidelberg, Germany. [Rookus, Matti A.] Netherlands Canc Inst, Dept Epidemiol, Amsterdam, Netherlands. [Verhoef, Senno] Netherlands Canc Inst, Family Canc Clin, Amsterdam, Netherlands. [Tilanus-Linthorst, Madeleine A.] Erasmus MC Daniel den Hoed Canc Ctr, Family Canc Clin, Dept Surg Oncol, Rotterdam, Netherlands. [Vreeswijk, Maaike P.; Asperen, Christi J.] Leiden Univ, Med Ctr, Ctr Human & Clin Genet, Leiden, Netherlands. [Bodmer, Danielle] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, NL-6525 ED Nijmegen, Netherlands. [Ausems, Margreet G. E. M.] Univ Med Ctr Utrecht, Dept Med Genet, Utrecht, Netherlands. [van Os, Theo A.] Univ Amsterdam, Acad Med Ctr, Dept Clin Genet, NL-1105 AZ Amsterdam, Netherlands. [Blok, Marinus J.] Univ Hosp Maastricht, Dept Clin Genet, Maastricht, Netherlands. [Meijers-Heijboer, Hanne E. J.] Vrije Univ Amsterdam Med Ctr, Dept Clin Genet, Amsterdam, Netherlands. [Dunning, Alison M.] Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England. [Evans, D. Gareth] Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England. [Pichert, Gabriella] Guys & St Thomas NHS Fdn Trust, London, England. [Cole, Trevor] Birmingham Womens Hosp Healthcare NHS Trust, W Midlands Reg Genet Serv, Birmingham, W Midlands, England. [Healey, Sue] Univ London, St Georges Hosp, Dept Clin Genet, London, England. [Brewer, Carole] Royal Devon & Exeter Hosp, Dept Clin Genet, Exeter EX2 5DW, Devon, England. [Morrison, Patrick J.] Belfast City Hosp, No Ireland Reg Genet Ctr, Belfast BT9 7AD, Antrim, North Ireland. [Porteous, Mary] Western Gen Hosp, SE Scotland Reg Genet Serv, Edinburgh EH4 2XU, Midlothian, Scotland. [Kennedy, M. John] Trinity Coll Dublin, Acad Unit Clin & Mol Oncol, Dublin, Eire, Ireland. [Kennedy, M. John] St James Hosp, Dublin, Eire, Ireland. [Rogers, Mark T.] Univ Wales Hosp, All Wales Med Genet Serv, Cardiff CF4 4XW, S Glam, Wales. [Side, Lucy E.] Great Ormond St Hosp Sick Children, NE Thames Reg Genet Serv, London WC1N 3JH, England. [Donaldson, Alan] St Michaels Hosp, Dept Clin Genet, Bristol, Avon, England. [Gregory, Helen] NHS Grampian, N Scotland Reg Genet Serv, Aberdeen, Scotland. [Gregory, Helen] Univ Aberdeen, Aberdeen, Scotland. [Daly, Mary B.] Fox Chase Canc Ctr, Dept Med Oncol, Womens Canc Program, Philadelphia, PA 19111 USA. [Stoppa-Lyonnet, Dominique; Moncoutier, Virginie; Castera, Laurent] Univ Paris 05, Inst Curie, INSERM, Serv Genet Oncol,U509, Paris, France. [Manoukian, Siranoush; Barjhoux, Laure] Univ Lyon, Ctr Leon Berard, CNRS, Equipe Labellisee LIGUE 2008,UMR5201, Lyon, France. [Bonadona, Valerie] Univ Lyon 1, CNRS, UMR5558, Lyon, France. [Bonadona, Valerie] Ctr Leon Berard, Unite Prevent & Epidemiol Genet, F-69373 Lyon, France. [Leroux, Dominique] Univ Grenoble, Inst Albert Bonniot, Grenoble, France. [Leroux, Dominique] CHU Grenoble, Dept Genet, F-38043 Grenoble, France. [Faivre, Laurence] Ctr Hosp Univ Dijon, Ctr Genet, Dijon, France. [Faivre, Laurence] Ctr Lutte Canc Georges Francois Leclerc, Dijon, France. [Lidereau, Rosette] INSERM, U735, Ctr Rene Huguenin, St Cloud, France. [Nogues, Catherine] Ctr Rene Huguenin, Epidemiol Clin, St Cloud, France. [Bignon, Yves-Jean] Ctr Jean Perrin, Dept Oncogenet, Clermont Ferrand, France. [Prieur, Fabienne] Ctr Hosp Univ St Etienne, Serv Genet Clin Chromosom & Mol, St Etienne, France. [Collonge-Rame, Marie-Agnes] CHU Besancon, Serv Genet Histol Biol Dev & Reprod, F-25030 Besancon, France. [Venat-Bouvet, Laurence] Ctr Hosp Univ Dupuytren, Dept Med Oncol, Limoges, France. [Fert-Ferrer, Sandra] Hotel Dieu Ctr Hosp, Lab Genet Chromosom, Chambery, France. [Miron, Alex] Dana Farber Canc Inst, Dept Canc Biol, Womens Cancers Program, Boston, MA 02115 USA. [Buys, Saundra S.] Univ Utah, Hlth Sci Ctr, Huntsman Canc Inst, Salt Lake City, UT USA. [Hopper, John L.] Univ Melbourne, Melbourne Sch Populat Hlth, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic, Australia. [John, Esther M.] Canc Prevent Inst Calif, Fremont, CA USA. [John, Esther M.] Stanford Univ, Sch Med, Stanford, CA 94305 USA. [Terry, Mary Beth] Columbia Univ, Joseph L Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10027 USA. [Goldgar, David] Univ Utah, Dept Dermatol, Salt Lake City, UT 84112 USA. [Hansen, Thomas V. O.; Jonson, Lars] Copenhagen Univ Hosp, Rigshosp, Dept Clin Biochem, Copenhagen, Denmark. [Ejlertsen, Bent] Copenhagen Univ Hosp, Rigshosp, Dept Oncol, Copenhagen, Denmark. [Agnarsson, Bjarni A.] Univ Hosp, Dept Pathol, Reykjavik, Iceland. [Agnarsson, Bjarni A.] Univ Iceland, Sch Med, Reykjavik, Iceland. [Offit, Kenneth; Kirchhoff, Tomas; Vijai, Joseph; Dutra-Clarke, Ana V. C.; Przybylo, Jennifer A.] Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, New York, NY 10021 USA. [Montagna, Marco; Casella, Cinzia] Ist Oncol Veneto IRCCS, Immunol & Mol Oncol Unit, Padua, Italy. [Imyanitov, Evgeny N.] NN Petrov Inst Oncol, St Petersburg, Russia. [Janavicius, Ramunas] Vilnius Univ Hosp Santariskiu Clin, Hematol Oncol & Transfus Med Ctr, Vilnius, Lithuania. [Blanco, Ignacio; Lazaro, Conxi] Catalan Inst Oncol, Hereditary Canc Program, Barcelona, Spain. [Moysich, Kirsten B.] Roswell Pk Canc Inst, Dept Canc Prevent & Control, Buffalo, NY 14263 USA. [Gronwald, Jacek; Karlan, Beth Y.] Cedars Sinai Med Ctr, Womens Canc Res Inst, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA USA. [Beattie, Mary S.] Univ Calif San Francisco, Canc Risk Program, San Francisco, CA 94143 USA. [Beattie, Mary S.] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA. [Beattie, Mary S.] Univ Calif San Francisco, Dept Epidemiol, San Francisco, CA 94143 USA. [Beattie, Mary S.] Univ Calif San Francisco, Dept Biostat, San Francisco, CA 94143 USA. [Schmutzler, Rita; Wappenschmidt, Barbara] Univ Hosp Cologne, Ctr Familial Breast & Ovarian Canc, Dept Obstet & Gynaecol, Cologne, Germany. [Schmutzler, Rita; Wappenschmidt, Barbara] Univ Hosp Cologne, Ctr Integrated Oncol, Cologne, Germany. [Miron, Alex] Tech Univ Munich, Klinikum Rechts Isar, Div Tumor Genet, Dept Obstet & Gynaecol, D-8000 Munich, Germany. [Ruehl, Ina] Univ Munich, Dept Obstet & Gynaecol, D-80539 Munich, Germany. [Fiebig, Britta] Univ Regensburg, Inst Human Genet, Regensburg, Germany. [Sutter, Christian] Univ Heidelberg, Dept Human Genet, Inst Human Genet, Mol Genet Lab, Heidelberg, Germany. [Arnold, Norbert] Univ Kiel, Univ Hosp Schleswig Holstein, Dept Obstet & Gynaecol, D-24098 Kiel, Germany. [Deissler, Helmut] Univ Hosp Ulm, Dept Obstet & Gynaecol, Ulm, Germany. [Varon-Mateeva, Raymonda] Charite, Campus Virchov Klinikum, Inst Human Genet, Berlin, Germany. [Kast, Karin] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Obstet & Gynaecol, Dresden, Germany. [Niederacher, Dieter] Univ Dusseldorf, Univ Hosp Dusseldorf, Dept Obstet & Gynaecol, D-4000 Dusseldorf, Germany. [Gadzicki, Dorothea] Hannover Med Sch, Inst Cell & Mol Pathol, D-3000 Hannover, Germany. [Cole, Trevor; de la Hoya, Miguel] Hosp San Carlos, Mol Oncol Lab, Madrid, Spain. [Nevanlinna, Heli] Univ Helsinki, Cent Hosp, Dept Obstet & Gynecol, FIN-00290 Helsinki, Finland. [Aittomaeki, Kristiina] Univ Helsinki, Cent Hosp, Dept Clin Genet, FIN-00290 Helsinki, Finland. [Simard, Jacques; Soucy, Penny] Ctr Hosp Univ Quebec, Canc Genom Lab, Quebec City, PQ, Canada. [Simard, Jacques; Soucy, Penny] Univ Laval, Quebec City, PQ, Canada. [Easton, Douglas F.] Univ Cambridge, Canc Res United Kingdom Genet Epidemiol Unit, Strangeways Res Lab, Cambridge, England. RP Ramus, SJ (reprint author), Univ So Calif, Dept Prevent Med, Harlyne Norris Res Tower,1450 Biggy St,Rm 2517K, Los Angeles, CA 90033 USA. EM sramus@usc.edu RI BYRSKI, Tomasz/I-2844-2014; Jakubowska, Anna/O-8050-2014; GLADIEFF, Laurence/O-5129-2014; Gardiner, Chris/F-1178-2011; Bodmer, D./L-4207-2015; Ligtenberg, Marjolijn/N-9666-2013; Gronwald, Jacek/A-4576-2017; manoukian, siranoush/E-7132-2017; Peissel, Bernard/E-8187-2017; Blanco, Ignacio/D-2565-2013; Oosterwijk, Jan C./G-5770-2011; Leroux, Dominique/G-7309-2014; Osorio, Ana/I-4324-2014; Arnold, Norbert/E-3012-2010; montagna, marco/E-2225-2012; Hereditario, Cancer/E-3311-2012; M Isabel, Tejada/E-2394-2012; Lester, Jenny/B-5933-2012; Andrulis, Irene/E-7267-2013; Joseph, Vijai/J-9158-2013; Hoogerbrugge, Nicoline/O-1016-2013; Radice, Paolo/O-3119-2013; Spurdle, Amanda/A-4978-2011; OI Kirchhoff, Tomas/0000-0002-9055-2364; Dunning, Alison Margaret/0000-0001-6651-7166; VENAT-BOUVET, Laurence/0000-0002-0716-2550; Evans, Gareth/0000-0002-8482-5784; GLADIEFF, Laurence/0000-0002-6980-9719; Gardiner, Chris/0000-0002-2318-0062; Ligtenberg, Marjolijn/0000-0003-1290-1474; Gronwald, Jacek/0000-0002-3643-2871; manoukian, siranoush/0000-0002-6034-7562; Peissel, Bernard/0000-0001-9233-3571; Janavicius, Ramunas/0000-0002-3773-8485; Nathanson, Katherine/0000-0002-6740-0901; Blanco, Ignacio/0000-0002-7414-7481; Osorio, Ana/0000-0001-8124-3984; Arnold, Norbert/0000-0003-4523-8808; montagna, marco/0000-0002-4929-2150; Joseph, Vijai/0000-0002-7933-151X; TEJADA, Maria-Isabel/0000-0002-7334-1864; Eeles, Rosalind/0000-0002-3698-6241; Ramus, Susan/0000-0003-0005-7798; Spurdle, Amanda/0000-0003-1337-7897; Papi, Laura/0000-0003-4552-9517; Nevanlinna, Heli/0000-0002-0916-2976 FU National Cancer Institute (NCI); National Institutes of Health [RFA-CA-06-503, P50 CA83638, U01 CA69631, 5U01 CA113916, R01 CA128978, P50 CA116201, R01 CA74415, RTICC 06/0020/0021, FIS 070359, FIS 090085]; Cancer Care Ontario [U01 CA69467]; Columbia University [U01 CA69398]; Fox Chase Cancer Center [U01 CA69631]; Huntsman Cancer Institute [U01 CA69446]; Northern California Cancer Center [U01 CA69417]; University of Melbourne [U01 CA69638]; Research Triangle Institute Informatics Support Center (RFP) [N02PC45022-46]; Neye Foundation; Fundacion Mutua Madrilena; Asociacion Espanola Contra el Cancer; Spanish Ministry of Science and Innovation [FIS PI08 1120]; Basque Foundation for Health Innovation and Research (BIOEF) [BIO07/CA/006]; Associazione Italiana per la Ricerca sul Cancro [4017, 8713]; Ministero della Salute [1 RC D/08/02B, RFPS-2006-3-340203]; Fondazione Italiana per la Ricerca sul Cancro; Ministero dell'Universita' e Ricerca [RBLAO3-BETH]; DKFZ; National Institute of Health Research; Royal Marsden NHS Foundation Trust; Cancer Research UK [C5047/A8385, C1287/A10118, C1287/A8874, C8197/A10123, C8197/A10865]; Eileen Stein Jacoby Fund; Ligue National Contre le Cancer; Association for International Cancer Research [AICR-07-0454]; Association "Le cancer du sein, parlons-en!"; Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBION); Dutch Cancer Society [NKI 1998-1854, NKI 2004-3088, NKI 2007-3756]; Helsinki University Central Hospital; Academy of Finland [132473]; Finnish Cancer Society; Sigrid Juselius Foundation; State Committee for Scientific Research [PBZ_KBN_122/P05/2004]; Canadian Institutes of Health Research [CRN_87521]; Canadian Breast Cancer Research Alliance [019511]; Istituto Oncologico Veneto-Hereditary Breast Ovarian Cancer Study: "Ministero della Salute" [RFPS 2006-5-341353, ACC2/R6.9]; National Breast Cancer Foundation; National Health and Medical Research Council (NHMRC); Queensland Cancer Fund; Cancer Council of New South Wales; Cancer Council of Victoria; Cancer Council of Tasmania; Cancer Council of South Australia; Cancer Foundation of Western Australia; Komen race for the cure [KG081527]; Breast Cancer Research Foundation; Lomangino Family Research Fund; US NCI at the National Institutes of Health [NO2-CP-11019-50, N02-CP-65504]; Westat, Inc, Rockville, MD; Russian Foundation for Basic Research [08-04-00369-a, 10-04-92110, 10-04-92110-a]; Federal Agency for Science and Innovations [02.740.11.0780]; Commission of the European Communities [PITN-GA-2009-238132]; Royal Society [JP090615]; Cancer Care Ontario, Canada; NCI, National Institutes of Health [RFA-CA-06-503]; Istituto Toscano Tumori; Swedish Cancer Society; CRUK; Department of Health's NIHR Biomedical Research Centre; Cancer Genetics Network [HHSN21620074400C]; American Cancer Society; L & S Milken Family Foundation; Entertainment Industry Foundation FX The CIMBA data management and data analysis was supported by Cancer Research UK grants (to D. F. E. and A. C. A.). G.C.-T. founded CIMBA to provide the infrastructure to study genetic modifiers of cancer risk for BRCA1 and BRCA2 mutation carriers.; Breast Cancer Family Registry (BCFR): Supported by the National Cancer Institute (NCI), National Institutes of Health under RFA-CA-06-503 and through cooperative agreements with members of the BCFR and Principal Investigators (PIs), including Cancer Care Ontario (U01 CA69467), Columbia University (U01 CA69398), Fox Chase Cancer Center (U01 CA69631), Huntsman Cancer Institute (U01 CA69446), Northern California Cancer Center (U01 CA69417), University of Melbourne (U01 CA69638), and Research Triangle Institute Informatics Support Center (RFP No. N02PC45022-46). The content of this article does not necessarily reflect the views or policies of the NCI or any of the collaborating centers in the BCFR nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government or the BCFR.; Copenhagen Breast Cancer Study (CBCS): Supported by the Neye Foundation.; Spanish National Cancer Center (CNIO) and the Spanish Consortium: Partially supported by Fundacion Mutua Madrilena, Asociacion Espanola Contra el Cancer, and the Spanish Ministry of Science and Innovation (FIS PI08 1120).; Funded in part by the Basque Foundation for Health Innovation and Research (BIOEF) (BIO07/CA/006).; CONsorzio Studi Italiani Tumori Ereditari Alla Mammella (CONSIT TEAM): Supported by grants from Associazione Italiana per la Ricerca sul Cancro (4017) and by funds from Italian citizens who allocated the 5x1000 share of their tax payment in support of the Fondazione IRCCS Istituto Nazionale Tumori, according to Italian laws (INT-Institutional strategic projects "5x1000") to P. P. Supported by grants from Ministero della Salute ("Progetto Tevere"-Linea 1 RC D/08/02B-"Progetto Tumori Femminili"-F/08/0PZ-Lineal RC CORR/08) to S. M. Supported by grants from Associazione Italiana per la Ricerca sul Cancro (8713) to L.O. Supported by grants from Ministero della Salute (Extraordinary National Cancer Program 2006, "Alleanza contro il Cancro" and Integrated Program N.5) to V. G. Supported by grants from Fondazione Italiana per la Ricerca sul Cancro (Special Project "Hereditary tumors"), Ministero della Salute (RFPS-2006-3-340203, Extraordinary National Cancer Program 2006 "Alleanza contro il Cancro," and "Progetto Tumori Femminili") and Ministero dell'Universita' e Ricerca (RBLAO3-BETH) to P.R.; Deutsches Krebsforschungszentrum (DKFZ) study: Supported by the DKFZ.; Epidemiological study of BRCA1 and BRCA2 mutation carriers (EMBRACE): Cancer Research UK grants (C1287/A10118 and C1287/A8874 to D. F. E., S. P., M. C., D. F., and C.O., and C8197/A10123 and C8197/A10865 to A. M. D.). National Institute for Health Research grant to the Biomedical Research Centre, Manchester (D. G. E.). The Investigators at the Institute of Cancer Research and the Royal Marsden NHS Foundation Trust are supported by a National Institute of Health Research grant to the Biomedical Research Centre at the Institute of Cancer Research and the Royal Marsden NHS Foundation Trust. Cancer Research UK grant (C5047/A8385 to R. E., E. B., and L. D'M.).; Fox Chase Cancer Center (FCCC): National Institutes of Health (P50 CA83638, U01 CA69631, and 5U01 CA113916 to A. K. G.); Eileen Stein Jacoby Fund.; The German Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC): German Cancer Aid (107054).; Genetic Modifiers of cancer risk in BRCA1/2 mutation carriers (GEMO): Cancer Genetics Network "Groupe Genetique et Cancer," Federation Nationale des Centres de Lutte Contre le Cancer, France, is supported by the Ligue National Contre le Cancer; Association for International Cancer Research grant (AICR-07-0454); Association "Le cancer du sein, parlons-en!" Award.; The Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON): Dutch Cancer Society (NKI 1998-1854, NKI 2004-3088 and NKI 2007-3756).; Hospital Clinico San Carlos: National Institute of Health Carlos III (RTICC 06/0020/0021, FIS 070359, and FIS 0900850).; Helsinki Breast Cancer Study (HEBCS): Helsinki University Central Hospital Research Fund, Academy of Finland (132473), the Finnish Cancer Society, and the Sigrid Juselius Foundation.; International Hereditary Cancer Center: State Committee for Scientific Research (PBZ_KBN_122/P05/2004).; Interdisciplinary Health Research International Team Breast Cancer Susceptibility (INHERIT BRCAs): Canadian Institutes of Health Research for the "CIHR Team in Familial Risks of Breast Cancer" program (CRN_87521); Canadian Breast Cancer Research Alliance (019511).; Istituto Oncologico Veneto-Hereditary Breast Ovarian Cancer Study: "Ministero della Salute" (RFPS 2006-5-341353, ACC2/R6.9).; KCONFAB: National Breast Cancer Foundation, the National Health and Medical Research Council (NHMRC), and the Queensland Cancer Fund, the Cancer Councils of New South Wales, Victoria, Tasmania and South Australia, and the Cancer Foundation of Western Australia. A. B. S. and G.C.-T. are Senior and Senior Principal Research Fellows of the NHMRC, respectively.; Mayo Clinic Study: National Institutes of Health (R01 CA128978 and P50 CA116201); Komen race for the cure (KG081527); Breast Cancer Research Foundation.; Memorial Sloane Kettering Cancer Center: Breast Cancer Research Foundation and the Lomangino Family Research Fund.; NCI: Intramural Research Program of the US NCI at the National Institutes of Health; support services contracts (NO2-CP-11019-50 and N02-CP-65504 to P. L. M. and M. H. G.) with Westat, Inc, Rockville, MD.; N.N. Petrov Institute of Oncology: Russian Foundation for Basic Research (08-04-00369-a, 10-04-92110 and 10-04-92110-a); Federal Agency for Science and Innovations (contract 02.740.11.0780); Commission of the European Communities (PITN-GA-2009-238132); Royal Society International Joint (JP090615).; Ontario Cancer Genetics Network (OCGN): Supported by Cancer Care Ontario, Canada (I. L. A.); and the NCI, National Institutes of Health under RFA-CA-06-503 and through cooperative agreements with members of the BCFR and PIs. The content of this article does not necessarily reflect the views or policies of the NCI or any of the collaborating centers in the Cancer Family Registry (CFR) nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government or the CFR.; Pisa Breast Cancer Study: Fondazione Cassa di Risparmio di Pisa (122/07) and grant 2010 from Istituto Toscano Tumori.; Swedish Breast Cancer Study (SWE-BRCA): Supported by the Swedish Cancer Society.; University of California Irvine: National Institutes of Health (R01 CA74415 to SLN and Y.C.D.).; University of California San Francisco (UCSF): Clinical and Translational Science Institute at the University of California, San Francisco (to M. S. B.).; UK and Gilda Radner Familial Ovarian Cancer Registries (UKGRFOCR): UKFOCR was supported by a project grant from CRUK to P. P. Some of this work was undertaken at UCLH/UCL who received a proportion of funding from the Department of Health's NIHR Biomedical Research Centre funding scheme.; University of Pennsylvania: Breast Cancer Research Foundation (K.L.N.); Cancer Genetics Network (HHSN21620074400C to S. M. D.).; Women's Cancer Research Institute: Supported in part by the American Cancer Society Early Detection Professorship, L & S Milken Family Foundation, and Entertainment Industry Foundation. NR 43 TC 22 Z9 22 U1 1 U2 11 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0027-8874 EI 1460-2105 J9 JNCI-J NATL CANCER I JI JNCI-J. Natl. Cancer Inst. PD JAN PY 2011 VL 103 IS 2 DI 10.1093/jnci/djq494 PG 12 WC Oncology SC Oncology GA 709WT UT WOS:000286472800008 PM 21169536 ER PT S AU Sa, JM Chong, JL Wellems, TE AF Sa, Juliana M. Chong, Jason L. Wellems, Thomas E. BE Docampo, R TI Malaria drug resistance: new observations and developments SO ESSAYS IN BIOCHEMISTRY: MOLECULAR PARASITOLOGY SE Essays in Biochemistry LA English DT Review; Book Chapter ID PLASMODIUM-FALCIPARUM MALARIA; SINGLE-NUCLEOTIDE POLYMORPHISMS; TRANSMEMBRANE PROTEIN PFCRT; PAPUA-NEW-GUINEA; CHLOROQUINE-RESISTANCE; ARTEMISININ RESISTANCE; QUININE RESISTANCE; IN-VITRO; PVCRT-O; SULFADOXINE-PYRIMETHAMINE AB Drug-resistant micro-organisms became widespread in the 20th Century, often with devastating consequences, in response to widespread use of natural and synthetic drugs against infectious diseases. Antimalarial resistance provides one of the earliest examples, following the introduction of new medicines that filled important needs for prophylaxis and treatment around the globe. In the present chapter, we offer a brief synopsis of major antimalarial developments from two natural remedies, the qinghaosu and cinchona bark infusions, and of synthetic drugs inspired by the active components of these remedies. We review some contributions that early efficacy studies of antimalarial treatment brought to clinical pharmacology, including convincing documentation of atebrine-resistant malaria in the 1940s, prior to the launching of what soon became first-choice antimalarials, chloroquine and amodiaquine. Finally, we discuss some new observations on the molecular genetics of drug resistance, including delayed parasite clearances that have been increasingly observed in response to artemisinin derivatives in regions of South-East Asia. C1 [Sa, Juliana M.; Chong, Jason L.; Wellems, Thomas E.] NIAID, Lab Malaria & Vector Res, NIH, Rockville, MD 20852 USA. RP Wellems, TE (reprint author), NIAID, Lab Malaria & Vector Res, NIH, Rockville, MD 20852 USA. EM twellems@niaid.nih.gov FU Intramural NIH HHS [Z99 AI999999] NR 121 TC 23 Z9 23 U1 0 U2 20 PU PORTLAND PRESS LTD PI LONDON PA 59 PORTLAND PL, LONDON W1N 3AJ, ENGLAND SN 0071-1365 BN 978-1-85578-184-9 J9 ESSAYS BIOCHEM JI Essays Biochem. PY 2011 VL 51 BP 137 EP 160 DI 10.1042/BSE0510137 PG 24 WC Biochemistry & Molecular Biology; Parasitology SC Biochemistry & Molecular Biology; Parasitology GA BZX40 UT WOS:000303215500010 PM 22023447 ER PT S AU Seol, Y Neuman, KC AF Seol, Yeonee Neuman, Keir C. BE Peterman, EJG Wuite, GJL TI Magnetic Tweezers for Single-Molecule Manipulation SO SINGLE MOLECULE ANALYSIS: METHODS AND PROTOCOLS SE Methods in Molecular Biology LA English DT Article; Book Chapter DE Magnetic tweezers; Image tracking; DNA; Topology; Single molecule ID OPTICAL MICROSCOPE; DNA; MICROMANIPULATION; MOTION; LEVEL; TRAP AB Magnetic tweezers provide a versatile tool enabling the application of force and torque on individual biomolecules. Magnetic tweezers are uniquely suited to the study of DNA topology and protein DNA interactions that modify DNA topology. Perhaps due to its presumed simplicity, magnetic tweezers instrumentation has been described in less detail than comparable techniques. Here, we provide a comprehensive description and guide for the design and implementation of a magnetic tweezers instrument for single-molecule measurements of DNA topology and mechanics. We elucidate magnetic trap design, as well as microscope and illumination setup, and provide a simple LabVIEW-based real-time position tracking algorithm. In addition, we provide procedures for production of supercoilable DNA tethers, flow-cell design, and construction tips. C1 [Seol, Yeonee; Neuman, Keir C.] NHLBI, Lab Mol Biophys, NIH, Bethesda, MD 20892 USA. RP Seol, Y (reprint author), NHLBI, Lab Mol Biophys, NIH, Bldg 10, Bethesda, MD 20892 USA. RI Neuman, Keir/F-7400-2011 OI Neuman, Keir/0000-0002-0863-5671 FU Intramural NIH HHS NR 21 TC 13 Z9 13 U1 0 U2 1 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA SN 1064-3745 BN 978-1-61779-281-6 J9 METHODS MOL BIOL JI Methods Mol. Biol. PY 2011 VL 783 BP 265 EP 293 DI 10.1007/978-1-61779-282-3_15 D2 10.1007/978-1-61779-282-3 PG 29 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Physics, Applied SC Biochemistry & Molecular Biology; Physics GA BYV34 UT WOS:000300583200015 PM 21909894 ER PT S AU Nordstrom, RJ AF Nordstrom, Robert J. BE Nordstrom, RJ Cote, GL TI Phantoms as Standards in Optical Measurements SO OPTICAL DIAGNOSTICS AND SENSING XI: TOWARD POINT-OF-CARE DIAGNOSTICS AND DESIGN AND PERFORMANCE VALIDATION OF PHANTOMS USED IN CONJUNCTION WITH OPTICAL MEASUREMENT OF TISSUE III SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Optical Diagnostics and Sensing XI - Toward Point-of-Care Diagnostics and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue III CY JAN 22-26, 2011 CL San Francisco, CA SP SPIE DE Phantoms; translational research; standardization ID TUMOR CHANGE MEASUREMENT; TRUTH DATA; ERROR SOURCES; THERAPY AB As optical technology progresses through the translational research pipeline, phantoms are becoming more important as verification tools to demonstrate proper performance of the devices before clinical studies. Because of the wide range of optical methodologies, there can be no single phantom that is useful for all modes of imaging, but protocols for phantom use should be organized to stand as standards. This paper discusses the features that phantoms must have to be considered as standards for optical measurements. C1 NCI, NIH, Bethesda, MD 20892 USA. RP Nordstrom, RJ (reprint author), NCI, NIH, 6130 Execut Blvd, Bethesda, MD 20892 USA. NR 7 TC 7 Z9 7 U1 1 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8443-7 J9 PROC SPIE PY 2011 VL 7906 AR 79060H DI 10.1117/12.876374 PG 5 WC Optics; Radiology, Nuclear Medicine & Medical Imaging SC Optics; Radiology, Nuclear Medicine & Medical Imaging GA BZS23 UT WOS:000302694400013 ER PT J AU Gilfillan, AM Beaven, MA AF Gilfillan, Alasdair M. Beaven, Michael A. TI Regulation of Mast Cell Responses in Health and Disease SO CRITICAL REVIEWS IN IMMUNOLOGY LA English DT Article DE mast cells; Fc epsilon RI; KIT; GPCRs; TLR/ST2/NOD-like receptors; signaling; immunity; allergies; autoimmune diseases ID FC-EPSILON-RI; PROTEIN-KINASE-C; THYMIC STROMAL LYMPHOPOIETIN; AFFINITY IGE RECEPTOR; A(3) ADENOSINE RECEPTOR; TOLL-LIKE RECEPTOR-2; SMOOTH-MUSCLE-CELLS; CATHELICIDIN ANTIMICROBIAL PEPTIDE; RAT GASTROINTESTINAL MUCOSA; RENIN-ANGIOTENSIN SYSTEM AB Mast cells are multifunctional cells that initiate not only IgE-dependent allergic diseases but also play a fundamental role in innate and adaptive immune responses to microbial infection. They are also thought to play a role in angiogenesis, tissue remodeling, wound healing, and tumor repression or growth. The broad scope of these physiologic and pathologic roles illustrates the flexible nature of mast cells, which is enabled in part by their phenotypic adaptability to different tissue microenvironments and their ability to generate and release a diverse array of bioactive mediators in response to multiple types of cell-surface and cytosolic receptors. There is increasing evidence from studies in cell cultures that release of these mediators can be selectively modulated depending on the types or groups of receptors activated. The intent of this review is to foster interest in the interplay among mast cell receptors to help understand the underlying mechanisms for each of the immunological and non-immunological functions attributed to mast cells. The second intent of this review is to assess the pathophysiologic roles of mast cells and their products in health and disease. Although mast cells have a sufficient repertoire of bioactive mediators to mount effective innate and adaptive defense mechanisms against invading microorganisms, these same mediators can adversely affect surrounding tissues in the host, resulting in autoimmune disease as well as allergic disorders. C1 [Gilfillan, Alasdair M.] NIAID, Lab Allerg Dis, NIH, Bethesda, MD 20892 USA. [Beaven, Michael A.] NHLBI, Lab Mol Immunol, Bethesda, MD 20892 USA. RP Gilfillan, AM (reprint author), NIAID, Lab Allerg Dis, NIH, 10 Ctr Dr,MSC 1881, Bethesda, MD 20892 USA. EM agilfillan@niaid.nih.gov FU National Institute of Allergy and Infectious Disease; National Heart, Lung, and Blood Institute, National Institutes of Health FX Work in the authors' laboratories has been supported by funding from the Intramural Research Program of the National Institute of Allergy and Infectious Disease and National Heart, Lung, and Blood Institute, National Institutes of Health. Due to space limitations, we do not cite all pertinent literature when adequately covered by most recent reviews. This does not imply that studies not quoted are of lesser merit. NR 454 TC 80 Z9 87 U1 3 U2 16 PU BEGELL HOUSE INC PI REDDING PA 50 CROSS HIGHWAY, REDDING, CT 06896 USA SN 1040-8401 J9 CRIT REV IMMUNOL JI Crit. Rev. Immunol. PY 2011 VL 31 IS 6 BP 475 EP 529 PG 55 WC Immunology SC Immunology GA 926IU UT WOS:000302825300003 PM 22321108 ER PT S AU Chadwick, RS Grosh, K AF Chadwick, Richard S. Grosh, Karl BE Shera, CA Olson, ES TI Wave Propagation and Amplification in the Cochlea-A Moderated Discussion SO WHAT FIRE IS IN MINE EARS: PROGRESS IN AUDITORY BIOMECHANICS: PROCEEDINGS OF THE 11TH INTERNATIONAL MECHANICS OF HEARING WORKSHOP SE AIP Conference Proceedings LA English DT Proceedings Paper CT 11th International Workshop on the Mechanics of Hearing CY JUL 16-22, 2011 CL Williams Coll, Williamstown, MA HO Williams Coll DE cochlear mechanics; traveling waves; DPOAEs; cochlear amplifier AB A discussion moderated by the authors on the topics "Wave Propagation in the Cochlea" and "The Cochlear Amplifier" was held on 21 July 2011 at the 11th International Mechanics of Hearing Workshop in Williamstown, Massachusetts. The paper provides an edited transcript of the session. C1 [Chadwick, Richard S.] NIDCD, Sect Auditory Mech, NIH, Bethesda, MD 20892 USA. [Grosh, Karl] Univ Michigan, Dept Mech Engn, Ann Arbor, MI USA. RP Chadwick, RS (reprint author), NIDCD, Sect Auditory Mech, NIH, Bethesda, MD 20892 USA. FU NIH [R13 DC010930]; AFOSR [FA9550-11-1-0102] FX Originally transcribed by Virginia Dodge from audio recordings, the discussion presented here was edited by R.S. Chadwick, K. Grosh, E.S. Olson, and C.A. Shera. Discussions at the Mechanics of HearingWorkshop were supported by grants from the NIH (R13 DC010930) and the AFOSR (FA9550-11-1-0102). NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-0975-0 J9 AIP CONF PROC PY 2011 VL 1403 DI 10.1063/1.3658173 PG 3 WC Audiology & Speech-Language Pathology; Physics, Applied SC Audiology & Speech-Language Pathology; Physics GA BZL60 UT WOS:000301945200122 ER PT S AU Lamb, JS Chadwick, RS AF Lamb, Jessica S. Chadwick, Richard S. BE Shera, CA Olson, ES TI Unraveling Traveling Waves Using WKB Modeling SO WHAT FIRE IS IN MINE EARS: PROGRESS IN AUDITORY BIOMECHANICS: PROCEEDINGS OF THE 11TH INTERNATIONAL MECHANICS OF HEARING WORKSHOP SE AIP Conference Proceedings LA English DT Proceedings Paper CT 11th International Workshop on the Mechanics of Hearing CY JUL 16-22, 2011 CL Williams Coll, Williamstown, MA HO Williams Coll DE cochlear mechanics; WKB; tectorial membrane; wave propagation; mode conversion ID TECTORIAL MEMBRANE; COCHLEAR MECHANICS; MOTION; CORTI; ORGAN; 2ND AB We calculate traveling waves in the cochlear partition using a WKB-based mechanical model in which motions of the fluid-interacting tectorial membrane (TM) and basilar membrane (BM) are degrees of freedom. We find that the two modes of motion that result manifest themselves as two traveling waves, each carried on both the BM and on the TM. The waves produce distinct tuning curves for the TM and the BM. We discuss the influence of the TM and coupling stiffnesses on the waves and tuning curves. We speculate how the two modes of motion we calculate and the differential motions they cause could influence the cochlear amplifier. We also discuss the possibility that mode conversion could occur in the cochlea. C1 [Lamb, Jessica S.; Chadwick, Richard S.] NIDCD, Sect Auditory Mech, NIH, Bethesda, MD 20892 USA. RP Lamb, JS (reprint author), NIDCD, Sect Auditory Mech, NIH, Bethesda, MD 20892 USA. NR 17 TC 0 Z9 0 U1 0 U2 0 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-0975-0 J9 AIP CONF PROC PY 2011 VL 1403 DI 10.1063/1.3658067 PG 7 WC Audiology & Speech-Language Pathology; Physics, Applied SC Audiology & Speech-Language Pathology; Physics GA BZL60 UT WOS:000301945200016 ER PT S AU Schones, DE Cui, KR Cuddapah, S AF Schones, Dustin E. Cui, Kairong Cuddapah, Suresh BE Castrillo, JI Oliver, SG TI Genome-Wide Approaches to Studying Yeast Chromatin Modifications SO YEAST SYSTEMS BIOLOGY: METHODS AND PROTOCOLS SE Methods in Molecular Biology LA English DT Article; Book Chapter DE Chromatin; histone modifications; ChIP-Seq; nucleosomes; genomics; epigenomics AB The genomes of eukaryotic organisms are packaged into nuclei by wrapping DNA around proteins in a structure known as chromatin. The most basic unit of chromatin, the nucleosome, consists of approximately 146 bp of DNA wrapped around an octamer of histone proteins. The placement of nucleosomes relative to a gene can influence the regulation of the transcription of this gene. Furthermore, the N-terminal tails of histone proteins are subjected to numerous post-translational modifications that are also known to influence gene regulation. In recent years, a number of genome-scale approaches to identify modifications to chromatin have been developed. Techniques combining chromatin immunoprecipitation (ChIP) with microarrays (ChIP-chip) and second-generation sequencing (ChIP-Seq) have led to great advances in our understanding of how chromatin modifications contribute to gene regulation. Many excellent protocols related to ChIP-chip have been published recently (Lieb, J. D. (2003) Genome-wide mapping of protein-DNA interactions by chromatin immunoprecipitation and DNA microarray hybridization. Methods Mol. Biol. 224,99-109.). For this reason, we will focus our attention here on the application of second-generation sequencing platforms to the study of chromatin modifications in yeast. As these genome-scale experiments require both wet-lab and bioinformatic components to reach their full potential, we will detail both the wet-lab protocols and bioinformatic steps necessary to frilly conduct genome-scale studies of chromatin modifications. C1 [Schones, Dustin E.] City Hope Natl Med Ctr, Duarte, CA 91010 USA. [Cuddapah, Suresh] NYU, Dept Environm Med, Tuxedo Pk, NY USA. [Cui, Kairong] NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA. RP Schones, DE (reprint author), City Hope Natl Med Ctr, 1500 E Duarte Rd, Duarte, CA 91010 USA. FU Intramural NIH HHS NR 9 TC 1 Z9 1 U1 1 U2 2 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA SN 1064-3745 BN 978-1-61779-172-7 J9 METHODS MOL BIOL JI Methods Mol. Biol. PY 2011 VL 759 BP 61 EP 71 DI 10.1007/978-1-61779-173-4_4 D2 10.1007/978-1-61779-173-4 PG 11 WC Biochemical Research Methods; Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA BYV48 UT WOS:000300590000005 PM 21863481 ER PT J AU Sclafani, V Paukner, A Suomi, SJ Ferrari, PF AF Sclafani, V. Paukner, A. Suomi, S. J. Ferrari, P. F. TI Imitation Promotes Affiliation in Infant Macaques (Macaca mulatta) SO FOLIA PRIMATOLOGICA LA English DT Meeting Abstract DE Imitation recognition; Affiliation; Empathy; Infant Development; Rhesus macaques C1 [Sclafani, V.; Ferrari, P. F.] Univ Parma, Dipartimento Biol Evolut & Funz, I-43100 Parma, Italy. [Paukner, A.; Suomi, S. J.] NICHHD, Comparat Ethol Lab, Poolesville, MD USA. EM valentinasclafani@libero.it NR 0 TC 0 Z9 0 U1 0 U2 0 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0015-5713 J9 FOLIA PRIMATOL JI Folia Primatol. PY 2011 VL 82 IS 4-5 BP 266 EP 266 PG 1 WC Zoology SC Zoology GA 917UE UT WOS:000302203300036 ER PT S AU Kuo, JC Han, XM Yates, JR Waterman, CM AF Kuo, Jean-Cheng Han, Xuemei Yates, John R., III Waterman, Clare M. BE Shimaoka, M TI Isolation of Focal Adhesion Proteins for Biochemical and Proteomic Analysis SO INTEGRIN AND CELL ADHESION MOLECULES: METHODS AND PROTOCOLS SE Methods in Molecular Biology LA English DT Article; Book Chapter DE Focal adhesion; Immunofluorescence; Western blotting; Mass spectrometry; Integrin ID SHOTGUN PROTEOMICS; MASS-SPECTROMETRY; YEAST PROTEOME; ABUNDANCE; MATRIX; MS/MS AB Focal adhesions (FAs) are discrete plasma membrane-associated adhesive organelles that play dual roles in cell force transduction and signaling. FAs consist of clustered transmembrane heterodimeric integrin extracellular matrix (ECM) receptors and a large number of cytoplasmic proteins that collectively form thin plaques linking the ECM to actin filament bundles of the cytoskeleton. FAs are complex organelles that can change their composition in response to biochemical or mechanical cues. These compositional differences may underlie the ability of FAs to mediate an array of important cell functions including adhesion, signaling, force transduction, and regulation of the cytoskeleton. These functions contribute to the physiological processes of the immune response, development, and differentiation. However, linking FA composition to FA function has been difficult since there has been no method to isolate intact FAs reproducibly and determine their composition. We report here a new method for isolating FA structures in cultured cells distinct from cytoplasmic, nuclear, and internal membranous organellar components of the cell. We provide protocols for validation of the fractionation by immunofluorescence and immuno-blotting, procedures for preparing the isolated FAs for mass spectrometric proteomic analysis, tips on data interpretation and analysis, and an approach for comparing FA composition in cells in which small GTPase signaling is perturbed. C1 [Kuo, Jean-Cheng; Waterman, Clare M.] NHLBI, Cell Biol & Physiol Ctr, Bethesda, MD 20892 USA. [Han, Xuemei; Yates, John R., III] Scripps Res Inst, La Jolla, CA 92037 USA. RP Kuo, JC (reprint author), NHLBI, Cell Biol & Physiol Ctr, Bldg 10, Bethesda, MD 20892 USA. OI Waterman, Clare/0000-0001-6142-6775 NR 22 TC 4 Z9 4 U1 0 U2 1 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA SN 1064-3745 BN 978-1-61779-165-9 J9 METHODS MOL BIOL JI Methods Mol. Biol. PY 2011 VL 757 BP 297 EP 323 DI 10.1007/978-1-61779-166-6_19 D2 10.1007/978-1-61779-166-6 PG 27 WC Biochemical Research Methods; Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA BYV44 UT WOS:000300588400019 ER PT S AU Calderwood, SK Prince, TL AF Calderwood, Stuart K. Prince, Thomas L. BE Calderwood, SK Prince, TL TI Molecular Chaperones Methods and Protocols Preface SO MOLECULAR CHAPERONES: METHODS AND PROTOCOLS SE Methods in Molecular Biology LA English DT Editorial Material; Book Chapter ID HEAT-SHOCK PROTEINS; STRESS; HSP70 C1 [Calderwood, Stuart K.] Harvard Univ, Beth Israel Deaconess Med Ctr, Dept Radiat Oncol, Boston, MA 02215 USA. [Prince, Thomas L.] NCI, Urol Oncol Branch, NIH, Bethesda, MD 20892 USA. RP Calderwood, SK (reprint author), Harvard Univ, Beth Israel Deaconess Med Ctr, Dept Radiat Oncol, Boston, MA 02215 USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA SN 1064-3745 BN 978-1-61779-294-6 J9 METHODS MOL BIOL JI Methods Mol. Biol. PY 2011 VL 787 BP VII EP IX D2 10.1007/978-1-61779-295-3 PG 3 WC Biochemical Research Methods; Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA BYL18 UT WOS:000299228600001 ER PT S AU Zhang, Y Chou, SD Murshid, A Prince, TL Schreiner, S Stevenson, MA Calderwood, SK AF Zhang, Yue Chou, Shiuh-Dih Murshid, Ayesha Prince, Thomas L. Schreiner, Sheila Stevenson, Mary Ann Calderwood, Stuart K. BE Calderwood, SK Prince, TL TI The Role of Heat Shock Factors in Stress-Induced Transcription SO MOLECULAR CHAPERONES: METHODS AND PROTOCOLS SE Methods in Molecular Biology LA English DT Article; Book Chapter DE Heat; Shock; Factor; Binding; Transcription ID PROTEIN HSP70; GENE-EXPRESSION; BINDING-PROTEIN; C-FOS; THERMOTOLERANCE; ACTIVATION; CELLS; YEAST; HSF1; REPRESSION AB Heat shock proteins (HSPs) are rapidly induced after stresses, such as heat shock, and accumulate at high concentrations in cells. HSP induction involves a family of heat shock transcription factors that bind the heat shock elements of the HSP genes and mediate transcription in trans. We discuss methods for the study of HSP binding to HSP promoters and the consequent increases in HSP gene expression in vitro and in vivo. C1 [Zhang, Yue; Stevenson, Mary Ann; Calderwood, Stuart K.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Radiat Oncol, Boston, MA 02215 USA. [Prince, Thomas L.] NCI, Urol Oncol Branch, NIH, Bethesda, MD 20892 USA. RP Zhang, Y (reprint author), Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Radiat Oncol, Boston, MA 02215 USA. FU NCI NIH HHS [R0-1CA094397, R01 CA047407, R01 CA077465, R01CA119045, R01 CA094397, R0-1CA047407, R01 CA119045] NR 40 TC 3 Z9 3 U1 0 U2 0 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA SN 1064-3745 BN 978-1-61779-294-6 J9 METHODS MOL BIOL JI Methods Mol. Biol. PY 2011 VL 787 BP 21 EP 32 DI 10.1007/978-1-61779-295-3_2 D2 10.1007/978-1-61779-295-3 PG 12 WC Biochemical Research Methods; Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA BYL18 UT WOS:000299228600003 PM 21898224 ER PT S AU Wiese, T Burns, J Yao, JH Summers, RM AF Wiese, Tatjana Burns, Joseph Yao, Jianhua Summers, Ronald M. GP IEEE TI COMPUTER-AIDED DETECTION OF SCLEROTIC BONE METASTASES IN THE SPINE USING WATERSHED ALGORITHM AND SUPPORT VECTOR MACHINES SO 2011 8TH IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING: FROM NANO TO MACRO SE IEEE International Symposium on Biomedical Imaging LA English DT Proceedings Paper CT 8th IEEE International Symposium on Biomedical Imaging (ISBI) - From Nano to Macro CY MAR 30-APR 02, 2011 CL Chicago, IL SP Inst Elect & Electron Engn, Engn Med & Biol Soc (EMBS), IEEE Signal Proc Soc (SPS) DE computer aided detection; bone metastasis; sclerotic lesion AB This work presents a computer-aided detection (CAD) system to aid radiologists in finding sclerotic bone metastases in the spine on CT images. The spine is first segmented using thresholding, region growing and a vertebra template. A watershed algorithm and a merging routine segment potential lesion candidates in each two-dimensional (2-D) axial CT image. Next, overlapping 2-D detections on sequential CT slices are merged to form 3-D candidate lesions. For each of these, 30 quantitative features based on shape, density, and location are computed. After a feature filter eliminates clearly false candidates, a ground truth on 10 clinical cases segmented manually by an expert, and the features of each CAD candidate are used to train seven support vector machines. The segmentation algorithm detects 164 out of the 212 manually segmented lesions. A ten-fold cross-validation trained on these detections results in 77.4% sensitivity at an average of 9.44 false positives per case. C1 [Wiese, Tatjana; Burns, Joseph; Yao, Jianhua; Summers, Ronald M.] NIH, Imaging Biomarkers & Comp Aided Diag Lab, Ctr Clin, Bethesda, MD 20892 USA. RP Wiese, T (reprint author), NIH, Imaging Biomarkers & Comp Aided Diag Lab, Ctr Clin, Bethesda, MD 20892 USA. NR 5 TC 3 Z9 3 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1945-7928 BN 978-1-4244-4128-0 J9 I S BIOMED IMAGING PY 2011 BP 152 EP 155 PG 4 WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Radiology, Nuclear Medicine & Medical Imaging GA BYH79 UT WOS:000298849400036 ER PT S AU Wang, SJ Anugu, V Nguyen, T Rose, N Burns, J McKenna, M Petrick, N Summers, RM AF Wang, Shijun Anugu, Vishal Tan Nguyen Rose, Natalie Burns, Joseph McKenna, Matthew Petrick, Nicholas Summers, Ronald M. GP IEEE TI FUSION OF MACHINE INTELLIGENCE AND HUMAN INTELLIGENCE FOR COLONIC POLYP DETECTION IN CT COLONOGRAPHY SO 2011 8TH IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING: FROM NANO TO MACRO SE IEEE International Symposium on Biomedical Imaging LA English DT Proceedings Paper CT 8th IEEE International Symposium on Biomedical Imaging (ISBI) - From Nano to Macro CY MAR 30-APR 02, 2011 CL Chicago, IL SP Inst Elect & Electron Engn, Engn Med & Biol Soc (EMBS), IEEE Signal Proc Soc (SPS) DE Computed tomographic colonography; computer aided detection; Amazon MTurk; alpha -integration; classifier fusion ID TOMOGRAPHIC VIRTUAL COLONOSCOPY; COMPUTER-AIDED DETECTION; FALSE POSITIVES; REDUCTION AB In this paper, we proposed a novel method to improve colonic polyp detection in computed tomographic colonography. Utilizing the human knowledge workers via the Amazon Mechanical Turk (MTurk) webservice, we distributed polyp detections from a computer-aided detection system (CAD) to anonymous online knowledge workers and asked them to distinguish true and false polyp candidates. We combined decisions from the CAD system (machine intelligence) and the MTurk workers (human intelligence) using alpha-integration. Preliminary experimental results indicated that the combined decisions were superior to either alone, with area under the receiver operating characteristic curve improving by 5.8% and 7.0% compared with CAD and MTurk workers alone, respectively. C1 [Wang, Shijun; Anugu, Vishal; Tan Nguyen; Rose, Natalie; Burns, Joseph; McKenna, Matthew; Summers, Ronald M.] NIH, Imaging Biomarkers & Comp Aided Diag Lab, Ctr Clin, Bldg 10,Room 1C224,MSC 1182, Bethesda, MD 20892 USA. [Petrick, Nicholas] U S Food & Drug Adm, Ctr Devices & Radiol Hlth, Silver Spring, MD 20993 USA. [Burns, Joseph] Univ Calif, Irvine Med Ctr, Dept Radiol Sci, Orange, CA 92868 USA. RP Summers, RM (reprint author), NIH, Imaging Biomarkers & Comp Aided Diag Lab, Ctr Clin, Bldg 10,Room 1C224,MSC 1182, Bethesda, MD 20892 USA. EM rms@mail.nih.gov FU Intramural Research Programs of the NIH Clinical Center; U.S. Food and Drug Administration FX This research was supported by the Intramural Research Programs of the NIH Clinical Center and the U.S. Food and Drug Administration (NP). NR 12 TC 7 Z9 7 U1 0 U2 3 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1945-7928 BN 978-1-4244-4128-0 J9 I S BIOMED IMAGING PY 2011 BP 160 EP 164 PG 5 WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Radiology, Nuclear Medicine & Medical Imaging GA BYH79 UT WOS:000298849400038 ER PT S AU Chen, M Carass, A Cuzzocreo, J Bazin, PL Reich, DS Prince, JL AF Chen, Min Carass, Aaron Cuzzocreo, Jennifer Bazin, Pierre-Louis Reich, Daniel S. Prince, Jerry L. GP IEEE TI TOPOLOGY PRESERVING AUTOMATIC SEGMENTATION OF THE SPINAL CORD IN MAGNETIC RESONANCE IMAGES SO 2011 8TH IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING: FROM NANO TO MACRO SE IEEE International Symposium on Biomedical Imaging LA English DT Proceedings Paper CT 8th IEEE International Symposium on Biomedical Imaging (ISBI) - From Nano to Macro CY MAR 30-APR 02, 2011 CL Chicago, IL SP Inst Elect & Electron Engn, Engn Med & Biol Soc (EMBS), IEEE Signal Proc Soc (SPS) DE Topology-preserving segmentation; digital homeomorphism; spinal cord segmentation; Magnetic resonance imaging; Magnetization transfer images ID MULTIPLE-SCLEROSIS; SEMIAUTOMATIC SEGMENTATION; CT IMAGES; MODEL AB Magnetic resonance images of the spinal cord play an important role in studying neurological diseases, particularly multiple sclerosis, where spinal cord atrophy can provide a measure of disease progression and disability. Current practices involve segmenting the spinal cord manually, which can be an inconsistent and time-consuming process. We present an automatic segmentation method for the spinal cord using a novel combination of deformable atlas based registration and topology preserving classification to address the challenges inherent to MR images of the spinal cord. Using real MR data, our method is shown to be highly accurate when compared to segmentations by manual raters. In addition, our results always maintain the correct topology of the spinal cord, therefore providing segmentations more consistent with the known anatomy. C1 [Chen, Min; Carass, Aaron; Prince, Jerry L.] Johns Hopkins Univ, Dept ECE, Image Anal & Commun Lab, Baltimore, MD 21218 USA. [Cuzzocreo, Jennifer; Bazin, Pierre-Louis] Johns Hopkins Univ, Lab Med Image Comp, Dept Radiol, Baltimore, MD 21218 USA. [Reich, Daniel S.] Johns Hopkins Univ, Dept Neurol, Baltimore, MD 21218 USA. [Chen, Min; Reich, Daniel S.] Natl Inst Neurol Disorders & Stroke, Translat Neuroradiol Unit, Bethesda, MD USA. RP Chen, M (reprint author), Johns Hopkins Univ, Dept ECE, Image Anal & Commun Lab, Baltimore, MD 21218 USA. EM mchen55@jhu.edu; aaron_carass@jhu.edu; pbazin1@jhmi.edu; daniel.reich@nih.gov; prince@jhu.edu RI Reich, Daniel/E-5701-2010; OI Reich, Daniel/0000-0002-2628-4334; Carass, Aaron/0000-0003-4939-5085 FU Intramural Research Program of NINDS; National Multiple Sclerosis Society FX This work was supported by the Intramural Research Program of NINDS. Data acquisition was supported by the National Multiple Sclerosis Society under a Tissue Repair grant to Peter Calabresi (Johns Hopkins University). NR 21 TC 8 Z9 8 U1 0 U2 3 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1945-7928 BN 978-1-4244-4128-0 J9 I S BIOMED IMAGING PY 2011 BP 1737 EP 1740 PG 4 WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Radiology, Nuclear Medicine & Medical Imaging GA BYH79 UT WOS:000298849400398 ER PT S AU Yoo, TS Hamilton, T Hurt, DE Caban, J Liao, D Chen, DT AF Yoo, Terry S. Hamilton, Trevor Hurt, Darrell E. Caban, Jesus Liao, David Chen, David T. GP IEEE TI TOWARD QUANTITATIVE X-RAY CT PHANTOMS OF METASTATIC TUMORS USING RAPID PROTOTYPING TECHNOLOGY SO 2011 8TH IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING: FROM NANO TO MACRO SE IEEE International Symposium on Biomedical Imaging LA English DT Proceedings Paper CT 8th IEEE International Symposium on Biomedical Imaging (ISBI) - From Nano to Macro CY MAR 30-APR 02, 2011 CL Chicago, IL SP Inst Elect & Electron Engn, Engn Med & Biol Soc (EMBS), IEEE Signal Proc Soc (SPS) DE Tomographic imaging; Computational imaging; X-ray imaging; Three-dimensional image acquisition ID SOLID TUMORS; RECIST; SIZE AB We are seeking ground-truth 3D X-ray CT phantoms with gradations of Hounsfield units that are indistinguishable from scans of human subjects. We modified a 3D printer, a ZCorp Spectrum 510, adding an iodine-based contrast agent, and printed physical models using a powder which consists mainly of cellulose and cornstarch. We scanned these 3D models with a Siemens Somatom Definition AS 128-slice CT scanner. By adjusting the level of iodine within the model, we are able to achieve Hounsfield units as high as 1056, mimicking bone, and as low as -450, similar to pulmonary tissue. We demonstrate how to generate grayscale images within a 3D model that can be imaged using a CT scanner. Unlike solid tumor phantoms, these models can accurately mimic lesions with indistinct boundaries similar to metastatic disease. Our intent is to evaluate the accuracy of computer aided diagnosis systems. C1 [Yoo, Terry S.; Hamilton, Trevor; Caban, Jesus; Liao, David; Chen, David T.] NIH, Off High Performance Comp & Commun, NLM, Bldg 10, Bethesda, MD 20892 USA. [Hurt, Darrell E.] NIH, Off Cyber Infrastructure & Comput Biol, NIAID, Bethesda, MD 20892 USA. RP Yoo, TS (reprint author), NIH, Off High Performance Comp & Commun, NLM, Bldg 10, Bethesda, MD 20892 USA. FU NIH FX This work was enabled in part by the generous help of the Radiology Department at the Georgetown University School of Medicine, in particular, Emmanuel Wilson and Kevin Cleary of the Georgetown ISIS Center. We are also indebted to the NIH Summer Internship Program for their support of two of our investigators during their brief tenure at NIH. NR 15 TC 5 Z9 5 U1 1 U2 6 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1945-7928 BN 978-1-4244-4128-0 J9 I S BIOMED IMAGING PY 2011 BP 1770 EP 1773 PG 4 WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Radiology, Nuclear Medicine & Medical Imaging GA BYH79 UT WOS:000298849400405 ER PT S AU Xue, ZY Long, LR Antani, S Thoma, GR AF Xue, Zhiyun Long, L. Rodney Antani, Sameer Thoma, George R. GP IEEE TI PATHOLOGY-BASED VERTEBRAL IMAGE RETRIEVAL SO 2011 8TH IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING: FROM NANO TO MACRO SE IEEE International Symposium on Biomedical Imaging LA English DT Proceedings Paper CT 8th IEEE International Symposium on Biomedical Imaging (ISBI) - From Nano to Macro CY MAR 30-APR 02, 2011 CL Chicago, IL SP Inst Elect & Electron Engn, Engn Med & Biol Soc (EMBS), IEEE Signal Proc Soc (SPS) DE Content Based Image Retrieval; Spine X-ray Biomedical Database; Anterior Osteophytes; Partial Shape Matching AB Searching for vertebrae in a large collection of spine X-ray images that are relevant to pathology is potentially important for providing assistance to radiologists and bone morphometrists. Developing appropriate methods for such searching tasks is very challenging due to the high similarities among vertebral shapes in contrast to the subtle dissimilarities that characterize the pathology. In this paper, we target two aspects of this problem: first, we develop mathematical features that can effectively represent the biomedical characteristics of interest; second, we exploit similarity learning to enhance and try to optimize the retrieval performance. We evaluate our proposed method on an expert-annotated dataset of 856 vertebrae and demonstrate its retrieval performance by precision-recall and average-precision graphs. We also demonstrate how we have integrated our method into our Web-accessible spine X-ray image retrieval system. C1 [Xue, Zhiyun; Long, L. Rodney; Antani, Sameer; Thoma, George R.] NIH, US Natl Lib Med, Bethesda, MD 20892 USA. RP Xue, ZY (reprint author), NIH, US Natl Lib Med, Bethesda, MD 20892 USA. OI Antani, Sameer/0000-0002-0040-1387 NR 5 TC 1 Z9 1 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1945-7928 BN 978-1-4244-4128-0 J9 I S BIOMED IMAGING PY 2011 BP 1893 EP 1896 PG 4 WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Radiology, Nuclear Medicine & Medical Imaging GA BYH79 UT WOS:000298849400433 ER PT S AU Rahman, MM Antani, SK Thoma, GR AF Rahman, Md Mahmudur Antani, Sameer K. Thoma, George R. GP IEEE TI A Biomedical Image Retrieval Framework Based on Classification-Driven Image Filtering and Similarity Fusion SO 2011 8TH IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING: FROM NANO TO MACRO SE IEEE International Symposium on Biomedical Imaging LA English DT Proceedings Paper CT 8th IEEE International Symposium on Biomedical Imaging (ISBI) - From Nano to Macro CY MAR 30-APR 02, 2011 CL Chicago, IL SP Inst Elect & Electron Engn, Engn Med & Biol Soc (EMBS), IEEE Signal Proc Soc (SPS) AB This paper presents a classification-driven biomedical image retrieval approach based on multi-class support vector machine (SVM) and uses image filtering and similarity fusion. In this framework, the probabilistic outputs of the SVM are exploited to reduce the search space for similarity matching. In addition, the predicted category of the query image is used for linear combination of similarity. The method is evaluated on a diverse collection of 5000 biomedical images of different modalities, body parts, and orientations and shows a halving in computation time (efficiency) and 10% to 15% improvement in precision at each recall level (effectiveness). C1 [Rahman, Md Mahmudur; Antani, Sameer K.; Thoma, George R.] NIH, US Natl Lib Med, Bethesda, MD 20892 USA. RP Rahman, MM (reprint author), NIH, US Natl Lib Med, Bldg 10, Bethesda, MD 20892 USA. OI Antani, Sameer/0000-0002-0040-1387 NR 9 TC 5 Z9 5 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1945-7928 BN 978-1-4244-4128-0 J9 I S BIOMED IMAGING PY 2011 BP 1905 EP 1908 PG 4 WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Radiology, Nuclear Medicine & Medical Imaging GA BYH79 UT WOS:000298849400436 ER PT S AU Bliton, J Yao, JH Bi, M Summers, RM AF Bliton, John Yao, Jianhua Bi, Mark Summers, Ronald M. GP IEEE TI IMPROVED 3D AUTOMATIC SEGMENTATION AND MEASUREMENT OF PLEURAL EFFUSIONS SO 2011 8TH IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING: FROM NANO TO MACRO SE IEEE International Symposium on Biomedical Imaging LA English DT Proceedings Paper CT 8th IEEE International Symposium on Biomedical Imaging (ISBI) - From Nano to Macro CY MAR 30-APR 02, 2011 CL Chicago, IL SP Inst Elect & Electron Engn, Engn Med & Biol Soc (EMBS), IEEE Signal Proc Soc (SPS) AB Pleural effusions are accumulations of fluid in the pleural space, usually associated with atelectasis of the adjacent lung. We have previously presented an automated method to measure the volume of pleural effusions on chest CT images [1]. This paper presents an improved version of the same method, which adds 3D surface modeling and additional propagation of the segmentation in the inferior direction. The improved method is also more robust to noise. We compared this method to manual segmentations and the previous method by applying it to 15 chest CT scans. The new segmentation, on average, increased estimated effusion volume by 11%, bringing it closer to the expected average. In addition, the correlation between manual and automatic effusion volumes increased from .59 to .81 (p = .13), indicating a better segmentation. C1 [Bliton, John; Yao, Jianhua; Bi, Mark; Summers, Ronald M.] NIH, Radiol & Image Sci Dept, Ctr Clin, Bethesda, MD 20892 USA. RP Bliton, J (reprint author), NIH, Radiol & Image Sci Dept, Ctr Clin, Bethesda, MD 20892 USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1945-7928 BN 978-1-4244-4128-0 J9 I S BIOMED IMAGING PY 2011 BP 1954 EP 1957 PG 4 WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Radiology, Nuclear Medicine & Medical Imaging GA BYH79 UT WOS:000298849400447 ER PT S AU Pamulapati, V Wood, BJ Linguraru, MG AF Pamulapati, Vivek Wood, Bradford J. Linguraru, Marius George GP IEEE TI INTRA-HEPATIC VESSEL SEGMENTATION AND CLASSIFICATION IN MULTI-PHASE CT USING OPTIMIZED GRAPH CUTS SO 2011 8TH IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING: FROM NANO TO MACRO SE IEEE International Symposium on Biomedical Imaging LA English DT Proceedings Paper CT 8th IEEE International Symposium on Biomedical Imaging (ISBI) - From Nano to Macro CY MAR 30-APR 02, 2011 CL Chicago, IL SP Inst Elect & Electron Engn, Engn Med & Biol Soc (EMBS), IEEE Signal Proc Soc (SPS) DE contrast-enhanced CT; liver; hepatic vein; portal vein; segmentation; classification; graph ID LIVER ANATOMY; ALGORITHMS AB The segmentation and classification of the major intrahepatic blood vessels are critical for the robust identification of the segmental anatomy of the liver. We propose a novel 4D graph-based method to segment and label the hepatic and portal veins. The algorithm uses multi-phase CT images to model the differential enhancement of the liver structures and Hessian-based vesselness likelihood to avoid the common pitfalls of graph cuts-based intrahepatic vessel segmentation. A hybrid classification step identifies the right, middle and left hepatic, and portal veins. We tested the method on CT data from nine patients and comparatively found that the new vesselness and enhancement graph costs are effective in reducing the effects of heterogeneous noise and vessel fragmentation. C1 [Pamulapati, Vivek; Wood, Bradford J.; Linguraru, Marius George] NIH, Ctr Clin, Bethesda, MD 20892 USA. RP Pamulapati, V (reprint author), NIH, Ctr Clin, Bethesda, MD 20892 USA. EM lingurarum@mail.nih.gov NR 18 TC 5 Z9 5 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1945-7928 BN 978-1-4244-4128-0 J9 I S BIOMED IMAGING PY 2011 BP 1982 EP 1985 PG 4 WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Radiology, Nuclear Medicine & Medical Imaging GA BYH79 UT WOS:000298849400454 ER PT S AU Liu, XF Linguraru, MG Yao, JH Summers, RM AF Liu, Xiaofeng Linguraru, Marius George Yao, Jianhua Summers, Ronald M. GP IEEE TI ABDOMINAL MULTI-ORGAN LOCALIZATION ON CONTRAST-ENHANCED CT BASED ON MAXIMUM A POSTERIORI PROBABILITY AND MINIMUM VOLUME OVERLAP SO 2011 8TH IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING: FROM NANO TO MACRO SE IEEE International Symposium on Biomedical Imaging LA English DT Proceedings Paper CT 8th IEEE International Symposium on Biomedical Imaging (ISBI) - From Nano to Macro CY MAR 30-APR 02, 2011 CL Chicago, IL SP Inst Elect & Electron Engn, Engn Med & Biol Soc (EMBS), IEEE Signal Proc Soc (SPS) DE contrast-enhanced CT; liver; spleen kidney; localization; maximum a posteriori probability ID AUTOMATED SEGMENTATION; LIVER; MODEL; ATLAS AB Multi-organ localization is required for many automated abdominal organ analysis tasks. We recently developed an automated organ localization method, which used an MAP framework, and applied it to non-contrast CT images. This method failed to localize smaller organs such as kidneys in some image data because it did not respect the spatial relationship among multiple organs. To address the problem, we extend the framework by modeling the inter-organ spatial relations using a minimum volume overlap constraint and incorporating it into the MAP framework. The method was validated on 17 contrast-enhanced CT images and identified correctly the liver, spleen, pancreas and kidneys in all data sets. The new method is more robust to organ pose variations, computationally fast, and improved significantly the localization of kidneys. C1 [Liu, Xiaofeng; Linguraru, Marius George; Yao, Jianhua; Summers, Ronald M.] NIH, Imaging Biomarkers & Comp Aided Diag Lab, Radiol & Imaging Sci Clin Ctr, Bethesda, MD 20892 USA. RP Liu, XF (reprint author), NIH, Imaging Biomarkers & Comp Aided Diag Lab, Radiol & Imaging Sci Clin Ctr, Bethesda, MD 20892 USA. EM lingurarum@mail.nih.gov NR 16 TC 1 Z9 1 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1945-7928 BN 978-1-4244-4128-0 J9 I S BIOMED IMAGING PY 2011 BP 2083 EP 2086 PG 4 WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Radiology, Nuclear Medicine & Medical Imaging GA BYH79 UT WOS:000298849400477 ER PT J AU Dorner, T Giesecke, C Lipsky, PE AF Doerner, Thomas Giesecke, Claudia Lipsky, Peter E. TI Mechanisms of B cell autoimmunity in SLE SO ARTHRITIS RESEARCH & THERAPY LA English DT Review ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; ADHESION MOLECULE EXPRESSION; VARIABLE REGION GENES; HUMAN PLASMA-CELLS; PERIPHERAL-BLOOD; LYMPHOCYTE HOMEOSTASIS; TOLERANCE CHECKPOINTS; SOMATIC HYPERMUTATION; RHEUMATOID-ARTHRITIS; DEPLETION THERAPY AB Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that is known to be associated with polyclonal B-cell hyper-reactivity. The underlying causes of the diffuse B-cell over-reactivity are unclear, but potential candidates include (a) intrinsic hyperreactivity leading to polyclonal B-cell activation with disturbed activation thresholds and ineffective negative selection; (b) lack of immunoregulatory functions; (c) secondary effects of an overactive inflammatory environment, such as overactive germinal center and ectopic follicular activity; and/or (d) disturbed cytokine production by non-B immune cells. These mechanisms are not mutually exclusive and may operate to varying extents and at varying times in SLE. Phenotypic and molecular studies as well as the results of recent clinical trials have begun to provide new insights to address these possibilities. Of importance, new information has made it possible to distinguish between the contribution played by abnormalities in central checkpoints that could lead to a pre-immune repertoire enriched in autoreactive B cells, on the one hand, and the possibility that autoimmunity arises in the periphery from somatic hypermutation and abnormal selection during T cell-dependent B-cell responses on the other. There is an intriguing possibility that apoptotic material bound to the surface of follicular dendritic cells positively selects autoreactive B cells that arise from non-autoreactive B-cell precursors as a result of somatic hypermutation and thereby promotes the peripheral emergence of autoimmunity. C1 [Doerner, Thomas; Giesecke, Claudia] Charite, Charite Ctr 12, Dept Med Rheumatol & Clin Immunol, D-10117 Berlin, Germany. [Doerner, Thomas; Giesecke, Claudia] Deutsch Rheumaforschungszentrum, D-10117 Berlin, Germany. [Lipsky, Peter E.] NIAMSD, NIH, Bethesda, MD 20892 USA. RP Dorner, T (reprint author), Charite, Charite Ctr 12, Dept Med Rheumatol & Clin Immunol, D-10117 Berlin, Germany. EM thomas.doerner@charite.de NR 81 TC 66 Z9 69 U1 2 U2 15 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1478-6354 J9 ARTHRITIS RES THER JI Arthritis Res. Ther. PY 2011 VL 13 IS 5 AR 243 DI 10.1186/ar3433 PG 12 WC Rheumatology SC Rheumatology GA 904DR UT WOS:000301174600053 PM 22078750 ER PT S AU Berenson, DF Weiss, AR Wan, ZL Weiss, MA AF Berenson, Daniel F. Weiss, Allison R. Wan, Zhu-li Weiss, Michael A. GP Annals NY Acad Sci TI Insulin analogs for the treatment of diabetes mellitus: therapeutic applications of protein engineering SO YEAR IN DIABETES AND OBESITY SE Annals of the New York Academy of Sciences LA English DT Article; Book Chapter DE protein design; bottom-up; nanotechnology; zinc finger; hormone ID ASSOCIATION PROPERTIES; SUBCUTANEOUS INJECTION; COST-EFFECTIVENESS; RECEPTOR-BINDING; SELF-ASSOCIATION; DELIVERY SYSTEM; CONCANAVALIN-A; ACTION PROFILE; BASAL INSULIN; NPH INSULIN AB The engineering of insulin analogs represents a triumph of structure-based protein design. A framework has been provided by structures of insulin hexamers. Containing a zinc-coordinated trimer of dimers, such structures represent a storage form of the active insulin monomer. Initial studies focused on destabilization of subunit interfaces. Because disassembly facilitates capillary absorption, such targeted destabilization enabled development of rapid-acting insulin analogs. Converse efforts were undertaken to stabilize the insulin hexamer and promote higher-order self-assembly within the subcutaneous depot toward the goal of enhanced basal glycemic control with reduced risk of hypoglycemia. Current products either operate through isoelectric precipitation (insulin glargine, the active component of Lantus(R); Sanofi-Aventis, Paris, France) or employ an albumin-binding acyl tether (insulin detemir, the active component of Levemir(R); Novo-Nordisk, Bagsvaerd, Denmark). To further improve pharmacokinetic properties, modified approaches are presently under investigation. Novel strategies have recently been proposed based on subcutaneous supramolecular assembly coupled to (i) large-scale allosteric reorganization of the insulin hexamer (the TR transition), (ii) pH-dependent binding of zinc ions to engineered His-X-3-His sites at hexamer surfaces, or (iii) the long-range vision of glucose-responsive polymers for regulated hormone release. Such designs share with wild-type insulin and current insulin products a susceptibility to degradation above room temperature, and so their delivery, storage, and use require the infrastructure of an affluent society. Given the global dimensions of the therapeutic supply chain, we envisage that concurrent engineering of ultra-stable protein analog formulations would benefit underprivileged patients in the developing world. C1 [Wan, Zhu-li; Weiss, Michael A.] Case Western Reserve Univ, Sch Med, Dept Biochem, Cleveland, OH 44106 USA. [Wan, Zhu-li; Weiss, Michael A.] Case Western Reserve Univ, Sch Med, Dept Biomed Engn, Cleveland, OH 44106 USA. [Wan, Zhu-li; Weiss, Michael A.] Case Western Reserve Univ, Sch Med, Dept Med, Cleveland, OH 44106 USA. [Berenson, Daniel F.] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT USA. [Weiss, Allison R.] NIDDKD, NIH, Bethesda, MD 20892 USA. RP Weiss, MA (reprint author), Case Western Reserve Univ, Sch Med, Dept Biochem, 10900 Euclid Ave, Cleveland, OH 44106 USA. EM Michael.Weiss@case.edu FU NIDDK NIH HHS [R01 DK079233, R01 DK079233-04] NR 118 TC 6 Z9 6 U1 1 U2 11 PU BLACKWELL SCIENCE PUBL PI OXFORD PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND SN 0077-8923 BN 978-1-57331-847-1 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PY 2011 VL 1243 BP E40 EP E54 DI 10.1111/j.1749-6632.2012.06468.x PG 15 WC Endocrinology & Metabolism; Multidisciplinary Sciences SC Endocrinology & Metabolism; Science & Technology - Other Topics GA BZG28 UT WOS:000301504400002 PM 22641195 ER PT S AU Su, HC Jing, H Zhang, Q AF Su, Helen C. Jing, Huie Zhang, Qian GP Annals NY Acad Sci TI DOCK8 deficiency SO YEAR IN HUMAN AND MEDICAL GENETICS: INBORN ERRORS OF IMMUNITY II SE Annals of the New York Academy of Sciences LA English DT Article; Book Chapter DE DOCK8; hyper-IgE syndrome; combined immunodeficiency; lymphopenia ID HYPER-IGE SYNDROME; HYPERIMMUNOGLOBULIN-E SYNDROME; STEM-CELL TRANSPLANTATION; RAC ACTIVATOR DOCK2; CYTOKINESIS 8 DOCK8; HOMOZYGOUS DELETIONS; STAT3 MUTATIONS; LUNG-CANCER; T-CELLS; IMMUNODEFICIENCY AB The discovery that loss-of-function mutations in the gene DOCK8 are responsible for most forms of autosomal recessive hyper-IgE syndrome and some forms of combined immunodeficiency without elevated serum IgE has led to studies into the immunopathogenesis of this disease. In this review, we relate the clinical features of this disease to studies using patients' cells and a mouse model of Dock8 deficiency, which have revealed how DOCK8 regulates T and B cell numbers and functions. The results of these studies help to explain how the absence of DOCK8 contributes to patients' susceptibility to viral, fungal, and bacterial infections. However, unanswered questions remain regarding how the absence of DOCK8 also leads to high IgE and allergic disease, predisposition for malignancy, and unusual clinical features, such as CNS abnormalities and autoimmunity, observed in some patients. C1 [Su, Helen C.; Jing, Huie; Zhang, Qian] NIAID, Host Def Lab, NIH, Bethesda, MD 20892 USA. RP Su, HC (reprint author), Bldg 10CRC,Room 5W3940,10CRC Ctr Dr,MSC 1456, Bethesda, MD 20892 USA. EM hsu@niaid.nih.gov RI Su, Helen/H-9541-2015; OI Su, Helen/0000-0002-5582-9110; Zhang, Qian/0000-0002-9040-3289 FU Intramural NIH HHS NR 51 TC 37 Z9 37 U1 0 U2 2 PU BLACKWELL SCIENCE PUBL PI OXFORD PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND SN 0077-8923 BN 978-1-57331-851-8 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PY 2011 VL 1246 BP 26 EP 33 DI 10.1111/j.1749-6632.2011.06295.x PG 8 WC Genetics & Heredity; Multidisciplinary Sciences SC Genetics & Heredity; Science & Technology - Other Topics GA BZG57 UT WOS:000301519900003 PM 22236427 ER PT J AU Deuster, PA Kim-Dorner, SJ Remaley, AT Poth, M AF Deuster, Patricia A. Kim-Dorner, Su Jong Remaley, Alan T. Poth, Merrily TI Allostatic Load and Health Status of African Americans and Whites SO AMERICAN JOURNAL OF HEALTH BEHAVIOR LA English DT Article DE aerobic fitness; body fat; depression; exercise; insulin; sleep habits ID CUMULATIVE BIOLOGICAL RISK; C-REACTIVE PROTEIN; INSULIN-RESISTANCE; NATIONAL SAMPLE; SOCIAL SUPPORT; NHANES-III; STRESS; CORTISOL; ADULTS; DISPARITIES AB Objectives: To compare health risks in 84 healthy African American and 45 white men and women after calculating allostatic load (AL) from biologic, psychosocial, and behavioral measures. Methods: Participants (18-45 years) ranging in weight from normal to obese and without hypertension or diabetes. Fitness, body fat, CRP, mood, social support, blood pressure, sleep and exercise habits, coping, and insulin responses were dichotomized as low/high risk and summed for AL. Results: African Americans (3.4 +/- 1.9) had significantly higher AL than that of whites (2.4 +/- 1.9; P<0.05). Significantly more African Americans had AL >= 3 (67.9%) than did whites (48.9%). Conclusions: Identifying cumulative AL may help identify and address the underpinnings of health disparities in African Americans. C1 [Deuster, Patricia A.; Kim-Dorner, Su Jong] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA. [Remaley, Alan T.] NIH, Dept Lab Med, Bethesda, MD 20892 USA. RP Deuster, PA (reprint author), Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA. EM pdeuster@usuhs.mil; sjkim@usuhs.mil RI Deuster, Patricia/G-3838-2015 OI Deuster, Patricia/0000-0002-7895-0888 NR 65 TC 8 Z9 8 U1 7 U2 12 PU PNG PUBLICATIONS PI OAK RIDGE PA 2205-K OAK RIDGE RD, #115, OAK RIDGE, NC 27310 USA SN 1945-7359 J9 AM J HEALTH BEHAV JI Am. J. Health Behav. PY 2011 VL 35 IS 6 BP 641 EP 653 PG 13 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 909MD UT WOS:000301567700001 PM 22251756 ER PT J AU Kaufman, AR Waters, EA Parascandola, M Augustson, EM Bansal-Travers, M Hyland, A Cummings, KM AF Kaufman, Annette R. Waters, Erika A. Parascandola, Mark Augustson, Erik M. Bansal-Travers, Maansi Hyland, Andrew Cummings, K. Michael TI Food and Drug Administration Evaluation and Cigarette Smoking Risk Perceptions SO AMERICAN JOURNAL OF HEALTH BEHAVIOR LA English DT Article DE Food and Drug Administration; evaluation; regulation; smoking; risk ID LIGHT CIGARETTES; SMOKERS; PRODUCTS AB Objectives: To examine the relationship between a belief about Food and Drug Administration (FDA) safety evaluation of cigarettes and smoking risk perceptions. Methods: A nationally representative, random-digit-dialed telephone survey of 1046 adult current cigarette smokers. Results: Smokers reporting that the FDA does not evaluate cigarettes for safety (46.1%), exhibited greater comprehension of the health risks of smoking and were more likely (48.5%) than other participants (33.6%) to report quit intentions. Risk perceptions partially mediated the relationship between FDA evaluation belief and quit intentions. Conclusions: These findings highlight the need for proactive, effective communication to the public about the aims of new tobacco product regulations. C1 [Kaufman, Annette R.] NCI, Behav Res Program, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA. [Waters, Erika A.] Washington Univ, Sch Med, Div Publ Hlth Sci, St Louis, MO USA. [Parascandola, Mark; Augustson, Erik M.] NCI, Tobacco Control Res Branch, DCCPS, Bethesda, MD 20892 USA. [Bansal-Travers, Maansi; Hyland, Andrew; Cummings, K. Michael] Roswell Pk Canc Inst, Dept Hlth Behav, Buffalo, NY USA. RP Kaufman, AR (reprint author), NCI, Behav Res Program, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA. EM kaufmana@mail.nih.gov OI Waters, Erika/0000-0001-7402-0133 FU Intramural NIH HHS [Z99 CA999999]; NCI NIH HHS [CA 16056-26, P30 CA016056] NR 27 TC 5 Z9 5 U1 1 U2 4 PU PNG PUBLICATIONS PI OAK RIDGE PA 2205-K OAK RIDGE RD, #115, OAK RIDGE, NC 27310 USA SN 1945-7359 J9 AM J HEALTH BEHAV JI Am. J. Health Behav. PY 2011 VL 35 IS 6 BP 766 EP 776 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 909MD UT WOS:000301567700012 PM 22251767 ER PT S AU Stokes, WS AF Stokes, William S. GP Annals NY Acad Sci TI Best practices for the use of animals in toxicological research and testing SO ANIMAL MODELS: THEIR VALUE IN PREDICTING DRUG EFFICACY AND TOXICITY SE Annals of the New York Academy of Sciences LA English DT Article; Proceedings Paper CT Conference on Animal Models and Their Value in Predicting Drug Efficacy and Toxicity CY SEP 15-16, 2011 CL New York, NY DE toxicology; animal welfare; animal models; alternative methods AB Animal models serve an important role in assessing preclinical safety and efficacy of new medicines and vaccines; however, such assessments can involve significant pain and distress and large numbers of animals. Best practice approaches seek to enhance animal well-being, minimize or avoid pain and distress, and use fewer animals. Advances in science and technology are providing opportunities for improved mechanism-based models and integrated safety assessments that will support improved animal welfare and reduce animal use. C1 Natl Inst Environm Hlth Sci, Natl Toxicol Program Interagency Ctr Evaluat Alte, Div Natl Toxicol Program, NIH, Res Triangle Pk, NC 27709 USA. RP Stokes, WS (reprint author), Natl Inst Environm Hlth Sci, Natl Toxicol Program Interagency Ctr Evaluat Alte, Div Natl Toxicol Program, NIH, POB 12233,Maildrop K2-16,111 TW Alexander Dr, Res Triangle Pk, NC 27709 USA. EM Stokes@niehs.nih.gov NR 9 TC 8 Z9 8 U1 2 U2 11 PU BLACKWELL SCIENCE PUBL PI OXFORD PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND SN 0077-8923 BN 978-1-57331-875-4 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PY 2011 VL 1245 BP 17 EP 20 DI 10.1111/j.1749-6632.2011.06334.x PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA BZE80 UT WOS:000301289400007 PM 22211968 ER PT J AU O'Hanlon, TP Li, ZY Gan, L Gourley, MF Rider, LG Miller, FW AF O'Hanlon, Terrance P. Li, Zhuoyan Gan, Lu Gourley, Mark F. Rider, Lisa G. Miller, Frederick W. TI Plasma proteomic profiles from disease-discordant monozygotic twins suggest that molecular pathways are shared in multiple systemic autoimmune diseases SO ARTHRITIS RESEARCH & THERAPY LA English DT Article DE autoimmunity; inflammation; human; proteome ID RHEUMATOID-ARTHRITIS; LUPUS-ERYTHEMATOSUS; MASS-SPECTROMETRY; PARAOXONASE 1; SYNOVIAL-FLUID; PON1 ACTIVITY; RANDOM FOREST; BIOMARKERS; CLASSIFICATION; POLYMORPHISMS AB Introduction: Although systemic autoimmune diseases (SAID) share many clinical and laboratory features, whether they also share some common features of pathogenesis remains unclear. We assessed plasma proteomic profiles among different SAID for evidence of common molecular pathways that could provide insights into pathogenic mechanisms shared by these diseases. Methods: Differential quantitative proteomic analyses (one-dimensional reverse-phase liquid chromatography-mass spectrometry) were performed to assess patterns of plasma protein expression. Monozygotic twins (four pairs discordant for systemic lupus erythematosus, four pairs discordant for juvenile idiopathic arthritis and two pairs discordant for juvenile dermatomyositis) were studied to minimize polymorphic gene effects. Comparisons were also made to 10 unrelated, matched controls. Results: Multiple plasma proteins, including acute phase reactants, structural proteins, immune response proteins, coagulation and transcriptional factors, were differentially expressed similarly among the different SAID studied. Multivariate Random Forest modeling identified seven proteins whose combined altered expression levels effectively segregated affected vs. unaffected twins. Among these seven proteins, four were also identified in univariate analyses of proteomic data (syntaxin 17, alpha-glucosidase, paraoxonase 1, and the sixth component of complement). Molecular pathway modeling indicated that these factors may be integrated through interactions with a candidate plasma biomarker, PON1 and the pro-inflammatory cytokine IL-6. Conclusions: Together, these data suggest that different SAID may share common alterations of plasma protein expression and molecular pathways. An understanding of the mechanisms leading to the altered plasma proteomes common among these SAID may provide useful insights into their pathogeneses. C1 [O'Hanlon, Terrance P.; Li, Zhuoyan; Gan, Lu; Rider, Lisa G.; Miller, Frederick W.] NIEHS, Environm Autoimmun Grp, NIH, DHHS, Bethesda, MD 20892 USA. [Gourley, Mark F.] Natl Inst Arthrit & Musculoskeletal Dis, NIH, DHHS, Bethesda, MD 20892 USA. RP O'Hanlon, TP (reprint author), NIEHS, Environm Autoimmun Grp, NIH, DHHS, 9000 Rockville Pike, Bethesda, MD 20892 USA. EM ohanlont@niehs.nih.gov RI Gan, Lu/L-5395-2014; OI Rider, Lisa/0000-0002-6912-2458; Miller, Frederick/0000-0003-2831-9593 FU National Institute of Environmental Health Sciences [Z01 ES101074]; NIH FX This work was supported by the intramural research program project Z01 ES101074 of the National Institute of Environmental Health Sciences, NIH. NR 47 TC 7 Z9 7 U1 0 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1478-6354 EI 1478-6362 J9 ARTHRITIS RES THER JI Arthritis Res. Ther. PY 2011 VL 13 IS 6 AR R181 DI 10.1186/ar3506 PG 13 WC Rheumatology SC Rheumatology GA 904EB UT WOS:000301175700001 PM 22044644 ER PT S AU Appelman, HD Umar, A Orlando, RC Sontag, SJ Nandurkar, S El-Zimaity, H Lanas, A Parise, P Lambert, R Shields, HM AF Appelman, Henry D. Umar, Asad Orlando, Roy C. Sontag, Stephen J. Nandurkar, Sanjay El-Zimaity, Hala Lanas, Angel Parise, Paolo Lambert, Rene Shields, Helen M. BA Giuli, R BF Giuli, R TI Barrett's esophagus: natural history SO BARRETT'S ESOPHAGUS: THE 10TH OESO WORLD CONGRESS PROCEEDINGS SE Annals of the New York Academy of Sciences LA English DT Article; Proceedings Paper CT 10th World Congress of the World Organization for Specialized Studies on Diseases of the Esophagus (OESO) CY AUG 28-31, 2010 CL Boston, MA DE reflux; adenocarcinoma; CDX2; dilated intercellular spaces; bile salts; high-grade dysplasia; Barrett's esophagus; biopsy protocol; adenocarcinoma; gastric atrophy; H. pylori; GERD; endoscopic grading system; Cag A-postive strain; metaplasia; laparoscopic surgery; high resolution endoscopy; narrow band imaging; trimodal technology; bimodal protocol; esophageal metaplasia; radiofrequency ablation; endoscopic mucosal resection; interobserver reproducibility ID HELICOBACTER-PYLORI INFECTION; HIGH-GRADE DYSPLASIA; GASTROESOPHAGEAL-REFLUX DISEASE; COLUMNAR-LINED ESOPHAGUS; ANTIREFLUX SURGERY; INTESTINAL METAPLASIA; SURGICAL-TREATMENT; UNITED-STATES; CANCER; ADENOCARCINOMA AB The following on the natural history of Barrett's esophagus (BE) includes commentary on histological sequences of the development of Barrett mucosa; the transformation of esophageal cells from squamous to columnar phenotype; the stages of natural history of dysplasia; the difficulties of predicting progression of dysplasia to adenocarcinoma; the preferable biopsy protocols; the role of Helicobacter pylori infection and gastric atrophy in the risk of BE; the value of decrease of proton pump inhibitor efficacy following eradication of H. pylori; the place of antireflux surgery in the natural history of BE; the newest procedures for the endoscopic detection of early neoplasia; and the essential importance of a good understanding of the natural history for the best management of high-grade dysplasia. C1 [Appelman, Henry D.] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA. [Umar, Asad] NCI, Canc Prevent Div, Rockville, MD USA. [Orlando, Roy C.] Univ N Carolina, Sch Med, Dept Cell & Mol Physiol, Chapel Hill, NC USA. [Sontag, Stephen J.] Edward Hines Jr VA Hosp, Hines, IL 60141 USA. [Nandurkar, Sanjay] Box Hill Hosp, Dept Gastroenterol, Box Hill, Vic, Australia. [El-Zimaity, Hala] Toronto Gen Hosp, Univ Hlth Network, Toronto, ON, Canada. [Lanas, Angel] Univ Zaragoza, CIBERehd, Aragon Hlth Res Inst, Dept Digest Dis, Zaragoza, Spain. [Lambert, Rene] Reg Referal Ctr Esophageal Pathol, Dept Gen Surg 4, Pisa, Italy. [Lambert, Rene] Int Agcy Res Canc, F-69372 Lyon, France. [Shields, Helen M.] Harvard Univ, Sch Med, Div Gastroenterol, Boston, MA USA. Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. RP Appelman, HD (reprint author), Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA. NR 56 TC 7 Z9 7 U1 0 U2 6 PU BLACKWELL SCIENCE PUBL PI OXFORD PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND SN 0077-8923 BN 978-1-57331-829-7 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PY 2011 VL 1232 BP 292 EP 308 DI 10.1111/j.1749-6632.2011.06057.x PG 17 WC Gastroenterology & Hepatology; Multidisciplinary Sciences SC Gastroenterology & Hepatology; Science & Technology - Other Topics GA BZD71 UT WOS:000301188400017 PM 21950819 ER PT J AU Mulligan, AM Couch, FJ Barrowdale, D Domchek, SM Eccles, D Nevanlinna, H Ramus, SJ Robson, M Sherman, M Spurdle, AB Wappenschmidt, B Lee, A McGuffog, L Healey, S Sinilnikova, OM Janavicius, R Hansen, TV Nielsen, FC Ejlertsen, B Osorio, A Munoz-Repeto, I Duran, M Godino, J Pertesi, M Benitez, J Peterlongo, P Manoukian, S Peissel, B Zaffaroni, D Cattaneo, E Bonanni, B Viel, A Pasini, B Papi, L Ottini, L Savarese, A Bernard, L Radice, P Hamann, U Verheus, M Meijers-Heijboer, HEJ Wijnen, J Garcia, EBG Nelen, MR Kets, CM Seynaeve, C Tilanus-Linthorst, MMA van der Luijt, RB van Os, T Rookus, M Frost, D Jones, JL Evans, DG Lalloo, F Eeles, R Izatt, L Adlard, J Davidson, R Cook, J Donaldson, A Dorkins, H Gregory, H Eason, J Houghton, C Barwell, J Side, LE McCann, E Murray, A Peock, S Godwin, AK Schmutzler, RK Rhiem, K Engel, C Meindl, A Ruehl, I Arnold, N Niederacher, D Sutter, C Deissler, H Gadzicki, D Kast, K Preisler-Adams, S Varon-Mateeva, R Schoenbuchner, I Fiebig, B Heinritz, W Schafer, D Gevensleben, H Caux-Moncoutier, V Fassy-Colcombet, M Cornelis, F Mazoyer, S Leone, M Boutry-Kryza, N Hardouin, A Berthet, P Muller, D Fricker, JP Mortemousque, I Pujol, P Coupier, I Lebrun, M Kientz, C Longy, M Sevenet, N Stoppa-Lyonnet, D Isaacs, C Caldes, T de la Hoya, M Heikkinen, T Aittomaki, K Blanco, I Lazaro, C Barkardottir, RB Soucy, P Dumont, M Simard, J Montagna, M Tognazzo, S D'Andrea, E Fox, S Yan, M Rebbeck, T Olopade, OI Weitzel, JN Lynch, HT Ganz, PA Tomlinson, GE Wang, XS Fredericksen, Z Pankratz, VS Lindor, NM Szabo, C Offit, K Sakr, R Gaudet, M Bhatia, J Kauff, N Singer, CF Tea, MK Gschwantler-Kaulich, D Fink-Retter, A Mai, PL Greene, MH Imyanitov, E O'Malley, FP Ozcelik, H Glendon, G Toland, AE Gerdes, AM Thomassen, M Kruse, TA Jensen, UB Skytte, AB Caligo, MA Soller, M Henriksson, K Wachenfeldt, V Arver, B Stenmark-Askmalm, M Karlsson, P Ding, YC Neuhausen, SL Beattie, M Pharoah, PDP Moysich, KB Nathanson, KL Karlan, BY Gross, J John, EM Daly, MB Buys, SM Southey, MC Hopper, JL Terry, MB Chung, W Miron, AF Goldgar, D Chenevix-Trench, G Easton, DF Andrulis, IL Antoniou, AC AF Mulligan, Anna Marie Couch, Fergus J. Barrowdale, Daniel Domchek, Susan M. Eccles, Diana Nevanlinna, Heli Ramus, Susan J. Robson, Mark Sherman, Mark Spurdle, Amanda B. Wappenschmidt, Barbara Lee, Andrew McGuffog, Lesley Healey, Sue Sinilnikova, Olga M. Janavicius, Ramunas Hansen, Thomas V. O. Nielsen, Finn C. Ejlertsen, Bent Osorio, Ana Munoz-Repeto, Ivan Duran, Mercedes Godino, Javier Pertesi, Maroulio Benitez, Javier Peterlongo, Paolo Manoukian, Siranoush Peissel, Bernard Zaffaroni, Daniela Cattaneo, Elisa Bonanni, Bernardo Viel, Alessandra Pasini, Barbara Papi, Laura Ottini, Laura Savarese, Antonella Bernard, Loris Radice, Paolo Hamann, Ute Verheus, Martijn Meijers-Heijboer, Hanne E. J. Wijnen, Juul Garcia, Encarna B. Gomez Nelen, Marcel R. Kets, C. Marleen Seynaeve, Caroline Tilanus-Linthorst, Madeleine M. A. van der Luijt, Rob B. van Os, Theo Rookus, Matti Frost, Debra Jones, J. Louise Evans, D. Gareth Lalloo, Fiona Eeles, Ros Izatt, Louise Adlard, Julian Davidson, Rosemarie Cook, Jackie Donaldson, Alan Dorkins, Huw Gregory, Helen Eason, Jacqueline Houghton, Catherine Barwell, Julian Side, Lucy E. McCann, Emma Murray, Alex Peock, Susan Godwin, Andrew K. Schmutzler, Rita K. Rhiem, Kerstin Engel, Christoph Meindl, Alfons Ruehl, Ina Arnold, Norbert Niederacher, Dieter Sutter, Christian Deissler, Helmut Gadzicki, Dorothea Kast, Karin Preisler-Adams, Sabine Varon-Mateeva, Raymonda Schoenbuchner, Ines Fiebig, Britta Heinritz, Wolfram Schaefer, Dieter Gevensleben, Heidrun Caux-Moncoutier, Virginie Fassy-Colcombet, Marion Cornelis, Francois Mazoyer, Sylvie Leone, Melanie Boutry-Kryza, Nadia Hardouin, Agnes Berthet, Pascaline Muller, Daniele Fricker, Jean-Pierre Mortemousque, Isabelle Pujol, Pascal Coupier, Isabelle Lebrun, Marine Kientz, Caroline Longy, Michel Sevenet, Nicolas Stoppa-Lyonnet, Dominique Isaacs, Claudine Caldes, Trinidad de la Hoya, Miguel Heikkinen, Tuomas Aittomaki, Kristiina Blanco, Ignacio Lazaro, Conxi Barkardottir, Rosa B. Soucy, Penny Dumont, Martine Simard, Jacques Montagna, Marco Tognazzo, Silvia D'Andrea, Emma Fox, Stephen Yan, Max Rebbeck, Tim Olopade, Olufunmilayo I. Weitzel, Jeffrey N. Lynch, Henry T. Ganz, Patricia A. Tomlinson, Gail E. Wang, Xianshu Fredericksen, Zachary Pankratz, Vernon S. Lindor, Noralane M. Szabo, Csilla Offit, Kenneth Sakr, Rita Gaudet, Mia Bhatia, Jasmine Kauff, Noah Singer, Christian F. Tea, Muy-Kheng Gschwantler-Kaulich, Daphne Fink-Retter, Anneliese Mai, Phuong L. Greene, Mark H. Imyanitov, Evgeny O'Malley, Frances P. Ozcelik, Hilmi Glendon, Gordon Toland, Amanda E. Gerdes, Anne-Marie Thomassen, Mads Kruse, Torben A. Jensen, Uffe Birk Skytte, Anne-Bine Caligo, Maria A. Soller, Maria Henriksson, Karin Wachenfeldt, von Anna Arver, Brita Stenmark-Askmalm, Marie Karlsson, Per Ding, Yuan Chun Neuhausen, Susan L. Beattie, Mary Pharoah, Paul D. P. Moysich, Kirsten B. Nathanson, Katherine L. Karlan, Beth Y. Gross, Jenny John, Esther M. Daly, Mary B. Buys, Saundra M. Southey, Melissa C. Hopper, John L. Terry, Mary Beth Chung, Wendy Miron, Alexander F. Goldgar, David Chenevix-Trench, Georgia Easton, Douglas F. Andrulis, Irene L. Antoniou, Antonis C. CA Breast Canc Family Registry EMBRACE GEMO Study Collaborators HEBON kConFab Investigators Ontario Canc Genetics Network SWE-BRCA CIMBA TI Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2 SO BREAST CANCER RESEARCH LA English DT Article ID GENOME-WIDE ASSOCIATION; ESTROGEN-RECEPTOR; GENETIC SUSCEPTIBILITY; CONFER SUSCEPTIBILITY; RISK PREDICTION; OVARIAN-CANCER; POPULATION; LOCI; VARIANTS; PHENOTYPE AB Introduction: Previous studies have demonstrated that common breast cancer susceptibility alleles are differentially associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. It is currently unknown how these alleles are associated with different breast cancer subtypes in BRCA1 and BRCA2 mutation carriers defined by estrogen (ER) or progesterone receptor (PR) status of the tumour. Methods: We used genotype data on up to 11,421 BRCA1 and 7,080 BRCA2 carriers, of whom 4,310 had been affected with breast cancer and had information on either ER or PR status of the tumour, to assess the associations of 12 loci with breast cancer tumour characteristics. Associations were evaluated using a retrospective cohort approach. Results: The results suggested stronger associations with ER-positive breast cancer than ER-negative for 11 loci in both BRCA1 and BRCA2 carriers. Among BRCA1 carriers, single nucleotide polymorphism (SNP) rs2981582 (FGFR2) exhibited the biggest difference based on ER status (per-allele hazard ratio (HR) for ER-positive = 1.35, 95% CI: 1.17 to 1.56 vs HR = 0.91, 95% CI: 0.85 to 0.98 for ER-negative, P-heterogeneity = 6.5 x 10(-6)). In contrast, SNP rs2046210 at 6q25.1 near ESR1 was primarily associated with ER-negative breast cancer risk for both BRCA1 and BRCA2 carriers. In BRCA2 carriers, SNPs in FGFR2, TOX3, LSP1, SLC4A7/NEK10, 5p12, 2q35, and 1p11.2 were significantly associated with ER-positive but not ER-negative disease. Similar results were observed when differentiating breast cancer cases by PR status. Conclusions: The associations of the 12 SNPs with risk for BRCA1 and BRCA2 carriers differ by ER-positive or ER-negative breast cancer status. The apparent differences in SNP associations between BRCA1 and BRCA2 carriers, and non-carriers, may be explicable by differences in the prevalence of tumour subtypes. As more risk modifying variants are identified, incorporating these associations into breast cancer subtype-specific risk models may improve clinical management for mutation carriers. C1 [Mulligan, Anna Marie; Andrulis, Irene L.] Univ Toronto, Dept Lab Med & Pathobiol, Canc Care Ontario, Toronto, ON M5S 1A8, Canada. [Mulligan, Anna Marie; O'Malley, Frances P.] St Michaels Hosp, Li Ka Shing Knowledge Inst, Dept Lab Med, Toronto, ON M5B 1W8, Canada. [Mulligan, Anna Marie; O'Malley, Frances P.] St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr, Toronto, ON M5B 1W8, Canada. [Couch, Fergus J.; Wang, Xianshu] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA. [Barrowdale, Daniel; Lee, Andrew; McGuffog, Lesley; Frost, Debra; Peock, Susan; Easton, Douglas F.; Antoniou, Antonis C.; EMBRACE] Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge CB1 8RN, England. [Domchek, Susan M.; Nathanson, Katherine L.] Univ Penn, Perelman Sch Med, Abramson Canc Ctr, Dept Med, Philadelphia, PA 19104 USA. [Eccles, Diana] Univ Southampton, Univ Hosp Southampton NHS Fdn Trust, Fac Med, Southampton SO16 6YD, Hants, England. [Nevanlinna, Heli; Heikkinen, Tuomas] Univ Helsinki, Dept Obstet & Gynecol, FIN-00290 Helsinki, Finland. [Aittomaki, Kristiina] Univ Helsinki, Cent Hosp, Dept Clin Genet, FIN-00290 Helsinki, Finland. [Ramus, Susan J.] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90089 USA. [Robson, Mark; Offit, Kenneth; Sakr, Rita; Bhatia, Jasmine; Kauff, Noah] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA. [Robson, Mark; Offit, Kenneth; Sakr, Rita; Bhatia, Jasmine; Kauff, Noah] Weill Cornell Med Coll, New York, NY USA. [Sherman, Mark] NCI, Div Canc Epidemiol & Genet, Hormonal & Reprod Epidemiol Branch, Rockville, MD 20852 USA. [Spurdle, Amanda B.; Healey, Sue; Chenevix-Trench, Georgia] Queensland Inst Med Res, Herston, Qld 4006, Australia. [Wappenschmidt, Barbara; Schmutzler, Rita K.; Rhiem, Kerstin] Univ Hosp Cologne, Dept Obstet & Gynaecol, Ctr Familial Breast & Ovarian Canc, D-50931 Cologne, Germany. [Wappenschmidt, Barbara; Schmutzler, Rita K.; Rhiem, Kerstin] Univ Hosp Cologne, Ctr Integrated Oncol, D-50931 Cologne, Germany. [Sinilnikova, Olga M.; Leone, Melanie; Boutry-Kryza, Nadia] Ctr Hosp Univ Lyon Ctr Leon Berard, Unite Mixte Genet Constitut Canc Frequents, F-69373 Lyon, France. [Sinilnikova, Olga M.; Mazoyer, Sylvie] Univ Lyon 1, Canc Res Ctr Lyon, CNRS, INSERM,U1052,UMR5286, F-69373 Lyon, France. [Janavicius, Ramunas] Vilnius Univ Hosp Santariskiu Clin, Hematol Oncol & Transfus Med Ctr, Dept Mol & Regenerat Med, LT-08661 Vilnius, Lithuania. [Janavicius, Ramunas] State Res Inst Innovat Med Ctr, LT-01102 Vilnius, Lithuania. [Hansen, Thomas V. O.; Nielsen, Finn C.] Copenhagen Univ Hosp, Rigshosp, Ctr Genom Med, DK-2100 Copenhagen, Denmark. [Ejlertsen, Bent] Copenhagen Univ Hosp, Rigshosp, Dept Oncol, DK-2100 Copenhagen, Denmark. [Osorio, Ana; Munoz-Repeto, Ivan; Benitez, Javier] Spanish Natl Canc Res Ctr, Human Canc Genet Programme, Human Genet Grp, Madrid 28029, Spain. [Osorio, Ana; Munoz-Repeto, Ivan; Benitez, Javier] Spanish Network Rare Dis CIBERER, Barcelona, Spain. [Duran, Mercedes] Univ Valladolid, IBGM UVA, Inst Biol & Mol Genet, Valladolid 47003, Spain. [Godino, Javier] Hosp Clin Univ Lozano Blesa, Inst Invest Sanitaria Aragon IIS, Zaragoza 50009, Spain. [Pertesi, Maroulio] Natl Ctr Sci Res Demokritos, IRRP, Mol Diagnost Lab, Athens 15310, Greece. [Peterlongo, Paolo; Radice, Paolo] Fdn IRCCS Ist Nazl Tumouri INT, Dept Prevent & Predict Med, Unit Mol Bases Genet Risk & Genet Testing, I-20133 Milan, Italy. [Peterlongo, Paolo; Radice, Paolo] Fdn Ist FIRC Oncol Mol, IFOM, I-20139 Milan, Italy. [Manoukian, Siranoush; Peissel, Bernard; Zaffaroni, Daniela; Cattaneo, Elisa] Fdn IRCCS Ist Nazl Tumouri INT, Dept Prevent & Predict Med, Unit Med Genet, I-20133 Milan, Italy. [Bonanni, Bernardo] Ist Europeo Oncol, Div Canc Prevent & Genet, I-20141 Milan, Italy. [Viel, Alessandra] IRCCS, Ctr Riferimento Oncol, Unit Expt Oncol 1, Aviano, PN, Italy. [Pasini, Barbara] Univ Turin, Dept Genet Biol & Biochem, Turin, Italy. [Papi, Laura] Univ Florence, Dept Clin Physiopathol, Med Genet Unit, Florence, Italy. [Ottini, Laura] Univ Roma La Sapienza, Dept Mol Med, Rome, Italy. [Savarese, Antonella] Regina Elena Inst Canc Res, Div Med Oncol, Rome, Italy. [Bernard, Loris] Ist Europeo Oncol, Dept Expt Oncol, Milan, Italy. [Bernard, Loris] Consortium Genom Technol Cogentech, Milan, Italy. [Hamann, Ute] DKFZ, Heidelberg, Germany. [Verheus, Martijn; Rookus, Matti] Netherlands Canc Inst, Dept Epidemiol, Amsterdam, Netherlands. [Meijers-Heijboer, Hanne E. J.] Vrije Univ Amsterdam Med Ctr, Dept Clin Genet, Amsterdam, Netherlands. [Wijnen, Juul] Leiden Univ, Med Ctr, Dept Clin Genet, Leiden, Netherlands. [Wijnen, Juul] Leiden Univ, Med Ctr, Dept Human Genet, Leiden, Netherlands. [Garcia, Encarna B. Gomez] MUMC, Sch Oncol & Dev Biol, Dept Clin Genet, Maastricht, Netherlands. [Garcia, Encarna B. Gomez] MUMC, Sch Oncol & Dev Biol, GROW, Maastricht, Netherlands. [Nelen, Marcel R.] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet 849, NL-6500 HB Nijmegen, Netherlands. [Kets, C. Marleen] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet 836, NL-6500 HB Nijmegen, Netherlands. [Seynaeve, Caroline] Erasmus Univ, Med Ctr, Family Canc Clin, Dept Med Oncol, Rotterdam, Netherlands. [Tilanus-Linthorst, Madeleine M. A.] Erasmus Univ, Med Ctr, Family Canc Clin, Dept Surg Oncol, Rotterdam, Netherlands. [van der Luijt, Rob B.] Univ Med Ctr Utrecht, Dept Med Genet, Utrecht, Netherlands. [van Os, Theo] Univ Amsterdam, Acad Med Ctr, Dept Clin Genet, NL-1105 AZ Amsterdam, Netherlands. [Jones, J. Louise] Queen Mary Univ London, Ctr Tumour Biol, Barts Canc Inst, London, England. [Evans, D. Gareth; Lalloo, Fiona] Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England. [Eeles, Ros] Inst Canc Res, Oncogenet Team, London, England. [Eeles, Ros] Royal Marsden NHS Fdn Trust, London, England. [Izatt, Louise] Guys & St Thomas NHS Fdn Trust, London, England. [Adlard, Julian] Yorkshire Reg Genet Serv, Leeds, W Yorkshire, England. [Davidson, Rosemarie] Yorkhill Hosp, Ferguson Smith Ctr Clin Genet, Glasgow, Lanark, Scotland. [Cook, Jackie] Sheffield Childrens Hosp, Sheffield Clin Genet Serv, Sheffield, S Yorkshire, England. [Donaldson, Alan] St Michaels Hosp, Dept Clin Genet, Bristol, Avon, England. [Dorkins, Huw] Kennedy Galton Ctr, NW Thames Reg Genet Serv, Harrow, Middx, England. [Gregory, Helen] NHS Grampian, N Scotland Reg Genet Serv, Aberdeen, Scotland. [Gregory, Helen] Univ Aberdeen, Aberdeen, Scotland. [Eason, Jacqueline] Nottingham Univ Hosp NHS Trust, Nottingham Clin Genet Serv, Nottingham, England. [Houghton, Catherine] Liverpool Womens NHS Fdn Trust, Cheshire & Merseyside Clin Genet Serv, Liverpool, Merseyside, England. [Barwell, Julian] Univ Hosp Leicester NHS Trust, Leicestershire Clin Genet Serv, Leicester, Leics, England. [Side, Lucy E.] Great Ormond St Hosp Sick Children, NE Thames Reg Genet Serv, London WC1N 3JH, England. [McCann, Emma] Glan Clwyd Gen Hosp, All Wales Med Genet Serv, Rhyl, Denbigh, Wales. [Murray, Alex] Singleton Hosp, All Wales Med Genet Serv, Swansea SA2 8QA, W Glam, Wales. [Godwin, Andrew K.] Univ Kansas, Med Ctr, Dept Pathol & Lab Med, Kansas City, KS 66103 USA. [Engel, Christoph] Univ Leipzig, Inst Med Informat Stat & Epidemiol, Leipzig, Germany. [Meindl, Alfons] Tech Univ Munich, Klinikum Rechts Isar, Div Tumour Genet, Dept Obstet & Gynaecol, D-8000 Munich, Germany. [Ruehl, Ina] Univ Munich, Dept Obstet & Gynaecol, Munich, Germany. [Arnold, Norbert] Univ Kiel, Univ Hosp Schleswig Holstein UKSH, Dept Obstet & Gynaecol, Kiel, Germany. [Niederacher, Dieter] Univ Dusseldorf, Univ Hosp Dusseldorf, Dept Obstet & Gynaecol, D-40225 Dusseldorf, Germany. [Sutter, Christian] Univ Heidelberg Hosp, Dept Human Genet, Inst Human Genet, Heidelberg, Germany. [Deissler, Helmut] Univ Hosp, Dept Obstet & Gynaecol, Ulm, Germany. [Gadzicki, Dorothea] Hannover Med Sch, Inst Cell & Mol Pathol, D-3000 Hannover, Germany. [Kast, Karin] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Obstet & Gynaecol, D-01062 Dresden, Germany. [Preisler-Adams, Sabine] Univ Munster, Inst Human Genet, D-4400 Munster, Germany. [Varon-Mateeva, Raymonda] Charite, Campus Virchov Klinikum, Inst Human Genet, Berlin, Germany. [Schoenbuchner, Ines] Univ Wurzburg, Inst Human Genet, Dept Med Genet, Ctr Familial Breast & Ovarian Canc, D-97070 Wurzburg, Germany. [Fiebig, Britta] Univ Regensburg, Inst Human Genet, D-8400 Regensburg, Germany. [Heinritz, Wolfram] Univ Leipzig, Inst Human Genet, Leipzig, Germany. [Schaefer, Dieter] Univ Hosp, Inst Human Genet, Frankfurt, Germany. [Gevensleben, Heidrun] Inst Canc Res, Breakthrough Breast Canc Res Ctr, London, England. [Caux-Moncoutier, Virginie; Fassy-Colcombet, Marion; Stoppa-Lyonnet, Dominique] Inst Curie, Serv Genet Oncol, Paris, France. [Cornelis, Francois] Avicenne Hosp, AP HP, Genet Unit, Paris, France. [Cornelis, Francois] Sud Francilien Hosp, Evry, France. [Cornelis, Francois] Univ Hosp, Clermont Ferrand, France. [Hardouin, Agnes; Berthet, Pascaline] Ctr Francois Baclesse, F-14021 Caen, France. [Muller, Daniele; Fricker, Jean-Pierre] CLCC Paul Strauss, Unite Oncogenet, Strasbourg, France. [Mortemousque, Isabelle] CHU Bretonneau, Serv Genet, F-37044 Tours, France. [Pujol, Pascal; Coupier, Isabelle] CHU Amaud de Villeneuve, Unite Oncogenet, Montpellier, France. [Lebrun, Marine; Kientz, Caroline] Ctr Hosp Univ St Etienne, Serv Genet Clin Chromosom & Mol, St Etienne, France. [Longy, Michel; Sevenet, Nicolas] Univ Bordeaux, Inst Bergonie, INSERM, Canc Genet Unit,U916, Bordeaux, France. [Stoppa-Lyonnet, Dominique] Inst Curie, INSERM, Unite U830, Paris, France. [Stoppa-Lyonnet, Dominique] Univ Paris 05, Fac Med, Paris, France. [Isaacs, Claudine] Georgetown Univ, Lombardi Comprehens Canc Ctr, Washington, DC USA. [Caldes, Trinidad; de la Hoya, Miguel] Hosp Clin San Carlos, Mol Oncol Lab, Madrid, Spain. [Blanco, Ignacio; Lazaro, Conxi] Hosp Duran i Reynals Bellvitge Biomed Res Inst ID, Inst Catala Oncol, Hereditary Canc Program, Barcelona, Spain. [Barkardottir, Rosa B.] Landspitali Univ Hosp, Dept Pathol, Reykjavik, Iceland. [Barkardottir, Rosa B.] Univ Iceland, Fac Med, Reykjavik, Iceland. [Soucy, Penny; Dumont, Martine; Simard, Jacques] CHU Quebec, Canc Genom Lab, Quebec City, PQ, Canada. [Simard, Jacques] Univ Laval, Fac Med, Dept Mol Med, Canada Res Chair Oncogenet, Quebec City, PQ G1K 7P4, Canada. [Montagna, Marco; Tognazzo, Silvia] Ist Oncol Veneto IOV IRCCS, Immunol & Mol Oncol Unit, I-35128 Padua, Italy. [D'Andrea, Emma] Univ Padua, Dept Oncol & Surg Sci, I-35128 Padua, Italy. [Fox, Stephen; kConFab Investigators] Peter MacCallum Canc Ctr, Melbourne, Vic 3052, Australia. [Yan, Max] Prince Wales Hosp, Dept Anat Pathol, Randwick, NSW 2031, Australia. [Rebbeck, Tim] Abramson Canc Ctr, Philadelphia, PA USA. [Rebbeck, Tim] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA. [Olopade, Olufunmilayo I.] Univ Chicago, Chicago, IL 60637 USA. [Weitzel, Jeffrey N.] City Hope Natl Med Ctr, Beckman Res Inst, City Hope Comprehens Canc Ctr, Duarte, CA USA. [Weitzel, Jeffrey N.; Ding, Yuan Chun; Neuhausen, Susan L.] City Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Duarte, CA USA. [Lynch, Henry T.] Creighton Univ, Dept Med, Omaha, NE 68178 USA. [Lynch, Henry T.] Creighton Univ, Dept Prevent Med & Publ Hlth, Omaha, NE 68178 USA. [Ganz, Patricia A.] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90024 USA. [Tomlinson, Gail E.] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA. [Tomlinson, Gail E.] Univ Texas SW Med Ctr Dallas, Harold C Simmons Comprehens Canc Ctr, Dallas, TX 75390 USA. [Tomlinson, Gail E.] Univ Texas Hlth Sci Ctr San Antonio, Dept Pediat, San Antonio, TX 78229 USA. [Fredericksen, Zachary; Pankratz, Vernon S.] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA. [Lindor, Noralane M.] Mayo Clin, Dept Med Genet, Rochester, MN USA. [Szabo, Csilla] Univ Delaware, Newark, DE USA. [Gaudet, Mia] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA. [Singer, Christian F.; Tea, Muy-Kheng; Gschwantler-Kaulich, Daphne; Fink-Retter, Anneliese] Med Univ Vienna, Dept Obstet Gynaecol, Vienna, Austria. [Singer, Christian F.; Tea, Muy-Kheng; Gschwantler-Kaulich, Daphne; Fink-Retter, Anneliese] Med Univ Vienna, Ctr Comprehens Canc, Vienna, Austria. [Mai, Phuong L.; Greene, Mark H.] US Natl Canc Inst, Clin Genet Branch, Div Canc Epidemiol & Genet, Rockville, MD USA. [Imyanitov, Evgeny] NN Petrov Inst Oncol, Oncol Mol Lab, St Petersburg, Russia. [Ozcelik, Hilmi; Andrulis, Irene L.] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada. [Andrulis, Irene L.] Univ Toronto, Canc Care Ontario, Dept Mol Genet, Toronto, ON M5S 1A8, Canada. [Toland, Amanda E.] Ohio State Univ, Ctr Comprehens Canc, Dept Mol Virol, Columbus, OH 43210 USA. [Toland, Amanda E.] Ohio State Univ, Ctr Comprehens Canc, Dept Immunol & Med Genet, Columbus, OH 43210 USA. [Toland, Amanda E.] Ohio State Univ, Ctr Comprehens Canc, Dept Internal Med, Columbus, OH 43210 USA. [Gerdes, Anne-Marie] Univ Copenhagen, Rigshosp, DK-2100 Copenhagen, Denmark. [Thomassen, Mads; Kruse, Torben A.] Odense Univ Hosp, DK-5000 Odense, Denmark. [Jensen, Uffe Birk] Aarhus Univ Hosp, Dept Clin Genet, DK-8000 Aarhus, Denmark. [Skytte, Anne-Bine] Vejle Hosp, Vejle, Denmark. [Caligo, Maria A.] Univ Pisa, Dept Lab Med, Sect Genet Oncol, Pisa, Italy. [Caligo, Maria A.] Univ Hosp Pisa, Pisa, Italy. [Soller, Maria] Univ Lund Hosp, Dept Clin Genet, S-22185 Lund, Sweden. [Henriksson, Karin] Univ Lund Hosp, Ctr Oncol, S-22185 Lund, Sweden. [Wachenfeldt, von Anna; Arver, Brita] Karolinska Univ Hosp, Dept Oncol, Stockholm, Sweden. [Stenmark-Askmalm, Marie] Linkoping Univ, Dept Clin & Expt Med, Div Clin Genet, Linkoping, Sweden. [Karlsson, Per] Sahlgrens Univ Hosp, Dept Oncol, Gothenburg, Sweden. [Beattie, Mary] Univ Calif San Francisco, UCSF Canc Risk Program, San Francisco, CA 94143 USA. [Beattie, Mary] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA. [Beattie, Mary] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA. [Pharoah, Paul D. P.] Univ Cambridge, Dept Oncol, Cambridge, England. [Moysich, Kirsten B.] Roswell Pk Canc Inst, Dept Canc Prevent & Control, Buffalo, NY 14263 USA. [Karlan, Beth Y.; Gross, Jenny] Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Womens Canc Program, Los Angeles, CA 90048 USA. [John, Esther M.] Canc Prevent Inst Calif, Dept Epidemiol, Fremont, CA USA. [Daly, Mary B.] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA. [Buys, Saundra M.] Univ Utah, Huntsman Canc Inst, Dept Oncol Sci, Salt Lake City, UT USA. [Southey, Melissa C.] Univ Melbourne, Dept Pathol, Genet Epidemiol Lab, Melbourne, Vic, Australia. [Hopper, John L.] Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic, Australia. [Terry, Mary Beth; Chung, Wendy] Columbia Univ, Dept Epidemiol, New York, NY USA. [Miron, Alexander F.] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA. [Goldgar, David] Univ Utah, Sch Med, Dept Dermatol, Salt Lake City, UT USA. [GEMO Study Collaborators] Federat Natl Ctr Lutte Canc, Canc Genet Network, Grp Genet & Canc, Paris, France. [Ontario Canc Genetics Network] Canc Care Ontario, Ontario Canc Genet Network, Toronto, ON M5G 2L7, Canada. [SWE-BRCA] Karolinska Inst, Stockholm, Sweden. RP Mulligan, AM (reprint author), Univ Toronto, Dept Lab Med & Pathobiol, Canc Care Ontario, 100 Coll St, Toronto, ON M5S 1A8, Canada. RI Spurdle, Amanda/A-4978-2011; Nelen, Marcel/L-4542-2015; Ligtenberg, Marjolijn/N-9666-2013; manoukian, siranoush/E-7132-2017; Peissel, Bernard/E-8187-2017; montagna, marco/E-2225-2012; Arnold, Norbert/E-3012-2010; D'Andrea, Emma/B-4374-2013; Andrulis, Irene/E-7267-2013; Hoogerbrugge, Nicoline/O-1016-2013; Radice, Paolo/O-3119-2013; Oosterwijk, Jan C./G-5770-2011; Toland, Amanda/E-4202-2011; Osorio, Ana/I-4324-2014; Bernard, Loris/K-5953-2014; Ehrencrona, Hans/M-5619-2014; GLADIEFF, Laurence/O-5129-2014 OI Evans, Gareth/0000-0002-8482-5784; Blanco, Ignacio/0000-0002-7414-7481; Ramus, Susan/0000-0003-0005-7798; Spurdle, Amanda/0000-0003-1337-7897; Barrowdale, Daniel/0000-0003-1661-3939; Papi, Laura/0000-0003-4552-9517; Kauff, Noah/0000-0001-7242-6156; Nevanlinna, Heli/0000-0002-0916-2976; Fox, Stephen/0000-0002-7648-8896; Ligtenberg, Marjolijn/0000-0003-1290-1474; manoukian, siranoush/0000-0002-6034-7562; Peissel, Bernard/0000-0001-9233-3571; Janavicius, Ramunas/0000-0002-3773-8485; Nordling, Margareta/0000-0002-4047-4994; Eeles, Rosalind/0000-0002-3698-6241; Robson, Mark/0000-0002-3109-1692; Nathanson, Katherine/0000-0002-6740-0901; montagna, marco/0000-0002-4929-2150; Arnold, Norbert/0000-0003-4523-8808; Osorio, Ana/0000-0001-8124-3984; Ehrencrona, Hans/0000-0002-5589-3622; GLADIEFF, Laurence/0000-0002-6980-9719 FU Breast Cancer Research Foundation; MacDonald Family Foundation; Komen Foundation; NIH, NCI [P50 CA 058207]; Avon Foundation; UCSF Helen Diller Family Comprehensive Cancer Center UK; CRUK; Russian Federation for Basic Research [10-04-92601, 10-04-92110, 11-04-00227]; Federal Agency for Science and Innovations [02.740.11.0780]; Commission of the European Communities [PITN-GA-2009-238132]; Royal Society [JP090615]; US National Cancer Institute; Westat, Inc., Rockville, MD; Starr Cancer Consortium; Norman and Carol Stone Genetic Research Fund; Robert and Kate Niehaus Clinical Genetics Initiative at MSKCC; NIH [CA116167, CA128978]; Research Excellence (SPORE) in Breast Cancer [CA116201]; Ministero della Salute [RFPS 2006-5-341353, ACC2/R6.9]; Kathleen Cuningham Consortium for Research into Familial Breast Cancer (kConFab); Icelandic Association; Landspitali University Hospital; NEYE Foundation; Deutsches Krebsforschungszentrum (DKFZ); Associazione Italiana per la Ricerca sul Cancro [4017]; Italian citizens; Fondazione Italiana per la Ricerca sul Cancro; Cancer Research UK [C12292/A11174, C1287/A10118, C1287/A11990, C5047/A8385]; NIHR; Eileen Stein Jacoby Fund; University of Kansas Cancer Center; Kansas Bioscience Authority Eminent Scholar Program; Familial Cancer Registry (CI); Tissue Culture Shared Registry at Georgetown University (NIH/NCI) [P30-CA051008]; Cancer Genetics Network [HHSN261200744000C]; Swing Fore the Cure; German Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC) GC-HBOC; German Cancer Aid [109076]; Centre of Molecular Medicine Cologne (CMMC); Ligue National Contre le Cancer; Association for International Cancer [AICR-07-0454]; Association "Le cancer du sein, parlons-en!" Award; European Community [223175 (HEALTH-F2-2009-223175)]; National Cancer Institute, National Institutes of Health [RFA-CA-06-503]; Liepaja's municipal council; [NO2-CP-11019-50]; [N02-CP-65504]; [U01CA69631]; [5U01CA113916] FX This work was supported by Cancer Research UK grants C12292/A11174 and C1287/A10118. The research leading to these results has received funding from the European Community's Seventh Framework Programme under grant agreement no 223175 (HEALTH-F2-2009-223175). ACA is a CR-UK Senior Cancer Research Fellow, DFE is CR-UK Principal Research Fellow. Study specific acknowledgments Breast Cancer Family Registry (BCFR) This work was supported by the National Cancer Institute, National Institutes of Health under RFA-CA-06-503 and through cooperative agreements with members of the Breast Cancer Family Registry (BCFR) and Principal Investigators, including Cancer Care Ontario (U01 CA69467), Columbia University (U01 CA69398), Fox Chase Cancer Center (U01 CA69631), Huntsman Cancer Institute (U01 CA69446), Cancer Prevention Institute of California (formerly the Northern California Cancer Center) (U01 CA69417), University of Melbourne (U01 CA69638), and Research Triangle Institute Informatics Support Center (RFP No. N02PC45022-46). Samples from the FCCC, HCI, and CPIC were processed and distributed by the Coriell institute for Medical Research. The content of this manuscript does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centers in the BCFR, nor does mention of trade names, commercial products or organizations imply endorsement by the US Government or the BCFR. The Baltic Familial Breast and Ovarian Cancer Consortium (BFBOCC Latvia and Lithuania) Lithuania: This work is supported by the Research Council of Lithuania grant LIG-19/2010 to Ramunas Janavicius. Latvia: We acknowledge Genome Database of Latvian Population, Latvian Biomedical Research and Study Center for providing data and DNA samples. This work is supported by Liepaja's municipal council to Laima Tihomirova (Latvian Biomedical Research and Study Centre). Copenhagen Breast Cancer Study (CBCS); We thank the NEYE Foundation for financial support The Deutsches Krebsforschungszentrum (DKFZ) study The study was supported by the DKFZ.; The study was supported by the DKFZ.; The CONSIT TEAM is supported by grants from Associazione Italiana per la Ricerca sul Cancro (4017) and by funds from Italian citizens who allocated the 5 x 1,000 share of their tax payment in support of the Fondazione IRCCS Istituto Nazionale Tumouri, according to Italian laws (INT-Institutional strategic projects "5 x 1000") to PP and grants from Fondazione Italiana per la Ricerca sul Cancro (Special Project "Hereditary tumours"), Ministero della Salute (Extraordinary National Cancer Program 2006 "Alleanza contro il Cancro", and "Progetto Tumouri Femminili") and Ministero dell'Universita' e Ricerca (RBLAO3-BETH) to PR. CONSIT TEAM acknowledges the contribution of Gaia Roversi, Carla B. Ripamonti, Marilena Morganti and Marco Pierotti of the of the Fondazione IRCCS Istituto Nazionale dei Tumouri, Milan, Italy; Monica Barile of the Istituto Europeo di Oncologia, Milan, Italy and Liliana Varesco of the Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy. Epidemiological study of BRCA1 and BRCA2 mutation carriers (EMBRACE) EMBRACE Collaborating Centers are: Coordinating Centre, Cambridge: Steve Ellis, Elena Fineberg, Radka Platte. North of Scotland Regional Genetics Service, Aberdeen: Zosia Miedzybrodzka. Northern Ireland Regional Genetics Service, Belfast: Patrick Morrison, Lisa Jeffers. West Midlands Regional Clinical Genetics Service, Birmingham: Trevor Cole, Kai-ren Ong, Jonathan Hoffman. South West Regional Genetics Service, Bristol: Margaret James. East Anglian Regional Genetics Service, Cambridge: Joan Paterson, Sarah Downing, Amy Taylor. Medical Genetics Services for Wales, Cardiff: T. Rogers,. St James's Hospital, Dublin & National Centre for Medical Genetics, Dublin: M. John Kennedy, David Barton. South East of Scotland Regional Genetics Service, Edinburgh: Mary Porteous, Sarah Drummond. Peninsula Clinical Genetics Service, Exeter: Carole Brewer, Emma Kivuva, Anne Searle, Selina Goodman, Kathryn Hill. West of Scotland Regional Genetics Service, Glasgow: Victoria Murday, Nicola Bradshaw, Lesley Snadden, Mark Longmuir, Catherine Watt, Sarah Gibson, Eshika Haque, Ed Tobias, Alexis Duncan. South East Thames Regional Genetics Service, Guy's Hospital London: Chris Jacobs, Caroline Langman, Anna Whaite. North West Thames Regional Genetics Service, Harrow. Leicestershire Clinical Genetics Service, Leicester. Yorkshire Regional Genetics Service, Leeds: Carol Chu, Julie Miller. Cheshire and Merseyside Clinical Genetics Service, Liverpool: Ian Ellis. Manchester Regional Genetics Service, Manchester: Jane Taylor. North East Thames Regional Genetics Service, NE Thames, London: Alison Male, Cheryl Berlin. Nottingham Centre for Medical Genetics, Nottingham: Rebecca Collier. Northern Clinical Genetics Service, Newcastle: Fiona Douglas, Oonagh Claber, Irene Jobson. Oxford Regional Genetics Service, Oxford: Lisa Walker, Diane McLeod, Dorothy Halliday, Sarah Durell, Barbara Stayner. The Institute of Cancer Research and Royal Marsden NHS Foundation Trust: Susan Shanley, Nazneen Rahman, Richard Houlston, Elizabeth Bancroft, Lucia D'Mello, Elizabeth Page, Audrey Ardern-Jones, Kelly Kohut, Jennifer Wiggins, Elena Castro, Anita Mitra, Lisa Robertson. North Trent Clinical Genetics Service, Sheffield: Oliver Quarrell, Cathryn Bardsley. South West Thames Regional Genetics Service, London: Shirley Hodgson, Sheila Goff, Glen Brice, Lizzie Winchester, Charlotte Eddy, Vishakha Tripathi, Virginia Attard. Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton: Anneke Lucassen, Gillian Crawford, Donna McBride, Sarah Smalley.; EMBRACE is supprted by Cancer Research UK Grants C1287/A10118 and C1287/A11990. D. Gareth Evans and Fiona Lalloo are supported by an NIHR grant to the Biomedical Research Centre, Manchester. The Investigators at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust are supported by an NIHR grant to the Biomedical Research Centre at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust. Ros Eeles, Elizabeth Bancroft and Lucia D'Mello are also supported by Cancer Research UK Grant C5047/A8385. Fox Chase Cancer Center Study (FCCC); A.K.G. was funded by U01CA69631, 5U01CA113916, and the Eileen Stein Jacoby Fund. The author acknowledges support from The University of Kansas Cancer Center and the Kansas Bioscience Authority Eminent Scholar Program. A. K. G. is the Chancellors Distinguished Chair in Biomedical Sciences endowed Professor.; Work is supported by the Familial Cancer Registry (CI) and the Tissue Culture Shared Registry at Georgetown University (NIH/NCI grant P30-CA051008), the Cancer Genetics Network (HHSN261200744000C) (CI), and Swing Fore the Cure (CI).; The German Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC) GC-HBOC is supported by a grant of the German Cancer Aid (grant 109076), the Centre of Molecular Medicine Cologne (CMMC).; The study was supported by the Ligue National Contre le Cancer; Association for International Cancer Research Grant (AICR-07-0454); and the Association "Le cancer du sein, parlons-en!" Award. We wish to thank all the GEMO collaborating groups for their contribution to this study. GEMO Collaborating Centers are: Coordinating Centres, Unite Mixte de Genetique Constitutionnelle des Cancers Frequents, Centre Hospitalier Universitaire de Lyon/Centre Leon Berard, et Equipe "Genetique du cancer du sein, Centre de Recherche en Cancerologie de Lyon: Laure Barjhoux, Carole Verny-Pierre, Sophie Giraud, and Service de Genetique Oncologique, Institut Curie, Parise Marion Gauthier-Villars, Bruno Buecher, Claude Houdayer, Muriel Belotti, Carole Tirapo, Antoine de Pauw. Institut Gustave Roussy, Villejuif: Brigitte Bressac-de-Paillerets, Audrey Remenieras, Veronique Byrde, Olivier Caron, Gilbert Lenoir. Centre Jean Perrin, Clermont-Ferrand: Yves-Jean Bignon, Nancy Uhrhammer. Centre Leon Berard, Lyon: Christine Lasset, Valerie Bonadona. Centre Francois Baclesse, Caen. Institut Paoli Calmettes, Marseille: Hagay Sobol, Violaine Bourdon, Tetsuro Noguchi, Francois Eisinger. Groupe Hospitalier Pitie-Salpetriere, Paris: Florence Coulet, Chrystelle Colas, Florent Soubrier. CHU de Arnaud-de-Villeneuve, Montpellier. Centre Oscar Lambret, Lille: Jean-Philippe Peyrat, Joelle Fournier, Francoise Revillion, Philippe Vennin, Claude Adenis. Hopital Rene Huguenin/Institut Curie, St Cloud: Etienne Rouleau, Rosette Lidereau, Liliane Demange, Catherine Nogues. Centre Paul Strauss, Strasbourg. Institut Bergonie, Bordeaux: Emmanuelle Barouk-Simonet, Francoise Bonnet, Virginie Bubien. Institut Claudius Regaud, Toulouse: Christine Toulas, Rosine Guimbaud, Laurence Gladieff, Viviane Feillel. CHU de Grenoble: Dominique Leroux, Helene Dreyfus, Christine Rebischung, Magalie Peysselon. CHU de Dijon: Fanny Coron, Laurence Faivre. CHU de St-Etienne: Fabienne Prieur. Hetel Dieu Centre Hospitalier, Chambery: Sandra Fert Ferrer. Centre Antoine Lacassagne, Nice: Marc Frenay. CHU de Limoges: Laurence Venat-Bouvet. CHU de Nantes: Capucine Delnatte. CHU Bretonneau, Tours. Creighton University, Omaha, USA: Henry T. Lynch, Carrie L. Snyder.; The ILUH group was supported by the Icelandic Association "Walking for Breast Cancer Research" and by the Landspitali University Hospital Research Fund.; This study was supported by "Ministero della Salute" ("Progetto Tumouri Femminili and grant numbers RFPS 2006-5-341353, ACC2/R6.9") Kathleen Cuningham Consortium for Research into Familial Breast Cancer (kConFab); The MAYO study was supported by NIH grants CA116167, CA128978, a Specialized Program of Research Excellence (SPORE) in Breast Cancer (CA116201), and awards from the Komen Foundation for the Cure and the Breast Cancer Research Foundation.; The study is supported by grant from the Breast Cancer Research Foundation, Starr Cancer Consortium, Norman and Carol Stone Genetic Research Fund, The Robert and Kate Niehaus Clinical Genetics Initiative at MSKCC; The research of Drs. PL Mai and MH Greene was supported by the Intramural Research Program of the US National Cancer Institute, and by support services contracts NO2-CP-11019-50 and N02-CP-65504 with Westat, Inc., Rockville, MD.; This work has been supported by the Russian Federation for Basic Research (grants 10-04-92601, 10-04-92110, 11-04-00227), the Federal Agency for Science and Innovations (contract 02.740.11.0780), the Commission of the European Communities (grant PITN-GA-2009-238132) and through a Royal Society International Joint grant (JP090615).; The study received funding from the NIH, NCI Bay Area Breast Cancer SPORE (P50 CA 058207) and the Avon Foundation. We acknowledge support from the UCSF Helen Diller Family Comprehensive Cancer Center UK and Gilda Radner Familial Ovarian Cancer Registries (UKGRFOCR) UKFOCR was supported by a project grant from CRUK to Paul Pharoah. We thank Simon Gayther, Carole Pye, Patricia Harrington and Eva Wozniak for their contributions towards the UKFOCR. We'd like to acknowledge the Roswell Park Alliance Foundation for their continued support of the Gilda Radner Ovarian Family Cancer Registry. GRFOCR would like to acknowledge Lara Sucheston (Department of Cancer Prevention and Control) and Kunle Odunsi (Departments Gynecologic Oncology and Immunology). University of Pennsylvania (UPENN); Work is supported by grants from the Breast Cancer Research Foundation (to KLN), MacDonald Family Foundation (SMD) and Komen Foundation (SMD) NR 51 TC 35 Z9 35 U1 2 U2 17 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1465-542X J9 BREAST CANCER RES JI Breast Cancer Res. PY 2011 VL 13 IS 6 AR R110 DI 10.1186/bcr3052 PG 20 WC Oncology SC Oncology GA 904DK UT WOS:000301173700002 PM 22053997 ER PT J AU Managadze, D Rogozin, IB Chernikova, D Shabalina, SA Koonin, EV AF Managadze, David Rogozin, Igor B. Chernikova, Diana Shabalina, Svetlana A. Koonin, Eugene V. TI Negative Correlation between Expression Level and Evolutionary Rate of Long Intergenic Noncoding RNAs SO GENOME BIOLOGY AND EVOLUTION LA English DT Article DE long noncoding RNA; ncRNA; RNA expression; genomic alignments; introns; RNA folding ID POLYMERASE-II TRANSCRIPTION; COMPUTER-ASSISTED ANALYSIS; PROTEIN-CODING GENE; SECONDARY STRUCTURE; SEQUENCE EVOLUTION; RAPID EVOLUTION; MAMMALIAN GENES; WEB SERVER; CONSERVATION; GENOME AB Mammalian genomes contain numerous genes for long noncoding RNAs (lncRNAs). The functions of the lncRNAs remain largely unknown but their evolution appears to be constrained by purifying selection, albeit relatively weakly. To gain insights into the mode of evolution and the functional range of the lncRNA, they can be compared with much better characterized protein-coding genes. The evolutionary rate of the protein-coding genes shows a universal negative correlation with expression: highly expressed genes are on average more conserved during evolution than the genes with lower expression levels. This correlation was conceptualized in the misfolding-driven protein evolution hypothesis according to which misfolding is the principal cost incurred by protein expression. We sought to determine whether long intergenic ncRNAs (lincRNAs) follow the same evolutionary trend and indeed detected a moderate but statistically significant negative correlation between the evolutionary rate and expression level of human and mouse lincRNA genes. The magnitude of the correlation for the lincRNAs is similar to that for equal-sized sets of protein-coding genes with similar levels of sequence conservation. Additionally, the expression level of the lincRNAs is significantly and positively correlated with the predicted extent of lincRNA molecule folding (base-pairing), however, the contributions of evolutionary rates and folding to the expression level are independent. Thus, the anticorrelation between evolutionary rate and expression level appears to be a general feature of gene evolution that might be caused by similar deleterious effects of protein and RNA misfolding and/or other factors, for example, the number of interacting partners of the gene product. C1 [Managadze, David; Rogozin, Igor B.; Chernikova, Diana; Shabalina, Svetlana A.; Koonin, Eugene V.] NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20892 USA. RP Koonin, EV (reprint author), NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bldg 10, Bethesda, MD 20892 USA. EM koonin@ncbi.nlm.nih.gov RI Shabalina, Svetlana/N-8939-2013 OI Shabalina, Svetlana/0000-0003-2272-7473 FU National Library of Medicine at National Institutes of Health (US Department Health and Human Services) FX We thank Liran Carmel, Joshua Cherry, Jean Thierri-Mieg, Mikhail Galperin, Alexander Lobkovsky, Kira Makarova, and Yuri Wolf for useful discussions. This work was supported by the Intramural Research Program of the National Library of Medicine at National Institutes of Health (US Department Health and Human Services). NR 90 TC 38 Z9 44 U1 0 U2 14 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1759-6653 J9 GENOME BIOL EVOL JI Genome Biol. Evol. PY 2011 VL 3 BP 1390 EP 1404 DI 10.1093/gbe/evr116 PG 15 WC Evolutionary Biology; Genetics & Heredity SC Evolutionary Biology; Genetics & Heredity GA 909AU UT WOS:000301535100031 PM 22071789 ER PT J AU Hong, SK Tanegashima, K Dawid, IB AF Hong, Sung-Kook Tanegashima, Kosuke Dawid, Igor B. TI XIer2 is required for convergent extension movements during Xenopus development SO INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY LA English DT Article DE XIer2; Xenopus; convergent extension ID GASTRULATION MOVEMENTS; FGF; ZEBRAFISH; BRACHYURY; PROTEIN; PATHWAY; TARGET; PIP92 AB Immediate early response 2 (Ier2) is a downstream target of fibroblast growth factor (FGF) signaling. In zebrafish, Ier2 is involved in left-right asymmetry establishment and in convergent extension movements. We isolated the Xenopus ier2 gene based on sequence similarity searches using multiple vertebrate species. Xenopus Ier2 has high homology in the N-terminal region to other vertebrate Ier2 proteins, and Xier2 transcripts were observed from oocytes through larval stages. Except for the maternal expression of xier2, the expression of this gene in the marginal region at gastrulation and in somites and the notochord at later stages is similar to the expression pattern of zebrafish ier2. XIer2 knockdown using antisense morpholinos resulted in defects of convergent extension leading to severe neural tube defects; overexpression of Ier2 showed similar, albeit milder phenotypes. Assays in animal cap explants likewise showed inhibition of elongation after blocking XIer2 expression. These results indicate that Xenopus Ier2 is essential for the execution of convergent extension movements during early Xenopus development. C1 [Hong, Sung-Kook; Tanegashima, Kosuke; Dawid, Igor B.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Mol Genet Lab, Program Genom Differentiat, NIH, Bethesda, MD 20892 USA. [Hong, Sung-Kook] NHGRI, Mol Genet Branch, NIH, Bethesda, MD 20892 USA. [Tanegashima, Kosuke] Tokyo Metropolitan Inst Med Sci, Tokyo 113, Japan. RP Dawid, IB (reprint author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Mol Genet Lab, Program Genom Differentiat, NIH, Bethesda, MD 20892 USA. EM idawid@nih.gov FU National Institute for Child Health and Human Development, NIH FX We thank Martha Rebbert for help with experiments and sequence alignments. This work was supported by the intramural research program of the National Institute for Child Health and Human Development, NIH. NR 16 TC 2 Z9 2 U1 0 U2 0 PU U B C PRESS PI BILBAO PA UNIV BASQUE COUNTRY, EDITORIAL SERVICES, PO BOX 1397, E-48080 BILBAO, SPAIN SN 0214-6282 J9 INT J DEV BIOL JI Int. J. Dev. Biol. PY 2011 VL 55 IS 10-12 BP 917 EP 921 DI 10.1387/ijdb.113288sh PG 5 WC Developmental Biology SC Developmental Biology GA 905YP UT WOS:000301312400003 PM 22252488 ER PT J AU Dente, L Gestri, G Tsang, M Kudoh, T Wilson, SW Dawid, IB Andreazzoli, M AF Dente, Luciana Gestri, Gaia Tsang, Michael Kudoh, Tetsuhiro Wilson, Stephen W. Dawid, Igor B. Andreazzoli, Massimiliano TI Cloning and developmental expression of zebrafish pdzrn3 SO INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY LA English DT Article DE PDZRN protein; PDZ domain; RING finger; zebrafish development; ventral retina ID DIFFERENTIATION; EMBRYOGENESIS; MIDLINE; FINGER; DOMAIN AB Pdzrn3, a member of the PDZRN/SEMCAP/LNX protein family containing a RING finger and two PDZ domains, has been implicated in myoblast and osteoblast differentiation. However, its spatio-temporal expression pattern during embryonic development has not been defined. Here, we describe the cloning and expression pattern of pdzrn3 during zebrafish development. We found that in addition to being expressed in several mesodermal structures, this gene displays specific expression in the central nervous system including rhombomere 1, ventral retina, thalamus and motor neurons, indicating a novel function during neural development. In particular, the absence of expression of pdzrn3 in the ventral retina of noi mutant fish suggests a possible role for this gene in regulating fasciculation and/or navigation of retinal ganglion cell axons. C1 [Dente, Luciana; Andreazzoli, Massimiliano] Univ Pisa, Dept Biol, I-56127 Pisa, Italy. [Gestri, Gaia; Wilson, Stephen W.] UCL, Dept Cell & Dev Biol, London WC1E 6BT, England. [Tsang, Michael; Kudoh, Tetsuhiro; Dawid, Igor B.] NICHD, Mol Genet Lab, NIH, Bethesda, MD USA. RP Andreazzoli, M (reprint author), Univ Pisa, Dept Biol, SS12 Abetone Brennero,4, I-56127 Pisa, Italy. EM mandreazzoli@biologia.unipi.it RI Zebrafish, UCL/A-3125-2009; TSANG, Michael/E-2758-2013; Tsang, Michael/I-9305-2014; OI TSANG, Michael/0000-0001-6384-2422; Tsang, Michael/0000-0001-7123-0063; Andreazzoli, Massimiliano/0000-0001-9633-204X FU National Institute of Child Health and Human Development, NIH; MIUR; Telethon; MRC FX This work was supported by the Intramural Research Program of the National Institute of Child Health and Human Development, NIH, by a grant from MIUR to M.A. and by grants from Telethon and MRC to G.G. NR 17 TC 6 Z9 6 U1 1 U2 3 PU U B C PRESS PI BILBAO PA UNIV BASQUE COUNTRY, EDITORIAL SERVICES, PO BOX 1397, E-48080 BILBAO, SPAIN SN 0214-6282 J9 INT J DEV BIOL JI Int. J. Dev. Biol. PY 2011 VL 55 IS 10-12 BP 989 EP 993 DI 10.1387/ijdb.113437ld PG 5 WC Developmental Biology SC Developmental Biology GA 905YP UT WOS:000301312400012 PM 22252497 ER PT S AU Bock, NA Hashim, E Kocharyan, A Silva, AC AF Bock, Nicholas A. Hashim, Eyesha Kocharyan, Ara Silva, Afonso C. BE Johnson, JI Zeigler, HP Hof, PR TI Visualizing myeloarchitecture with magnetic resonance imaging in primates SO RESOURCES AND TECHNOLOGICAL ADVANCES FOR STUDIES OF NEUROBEHAVIORAL EVOLUTION SE Annals of the New York Academy of Sciences LA English DT Article; Proceedings Paper CT Conference on New Studies of Neurobehavioral Evolution CY JUN 25-28, 2010 CL Armed Forces Inst Pathol, Washington, DC SP Neuroscience Assoc Inc, Michigan State Univ, Dept Radiol HO Armed Forces Inst Pathol DE magnetic resonance imaging; brain mapping; cortex; myelin; primate ID MONKEY CALLITHRIX-JACCHUS; DORSOLATERAL FRONTAL-CORTEX; MARMOSET MONKEY; CEREBRAL-CORTEX; VISUOTOPIC ORGANIZATION; EXTRASTRIATE CORTICES; COMMON MARMOSET; AREAS; CONNECTIONS; DORSAL AB The pattern of myelination over the cerebral cortex, termed myeloarchitecture, is an established and often-used feature to visualize cortical organization with histology in a variety of primate species. In this paper, we use in vivo magnetic resonance imaging (MRI) and advanced image processing using surface rendering to visualize and characterize myeloarchitecture in a small nonhuman primate, the common marmoset (Callithrix jacchus). Through images made in four female adult marmosets, we produce a representative 3D map of marmoset myeloarchitecture and flatten and annotate this map to show the location and extent of a variety of major areas of the cortex, including the primary visual, auditory, and somatosensory areas. By treating our MRI data as a surface, we can measure the surface area of cortical areas, and we present these measurements here to summarize cortical organization in the marmoset. C1 [Bock, Nicholas A.; Hashim, Eyesha] McMaster Univ, Hamilton, ON L8S 4K1, Canada. [Kocharyan, Ara; Silva, Afonso C.] Natl Inst Neurol Disorders & Stroke, Cerebral Microcirculat Unit, Lab Funct & Mol Imaging, NIH, Bethesda, MD USA. RP Bock, NA (reprint author), McMaster Univ, 1280 Main St W, Hamilton, ON L8S 4K1, Canada. EM bockn@mcmaster.ca FU Intramural NIH HHS [ZIA NS003041-04] NR 45 TC 19 Z9 19 U1 2 U2 6 PU BLACKWELL SCIENCE PUBL PI OXFORD PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND SN 0077-8923 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PY 2011 VL 1225 IS S1 BP E171 EP E181 DI 10.1111/j.1749-6632.2011.06000.x PG 11 WC Multidisciplinary Sciences; Neurosciences SC Science & Technology - Other Topics; Neurosciences & Neurology GA BZD69 UT WOS:000301187000011 PM 21599695 ER PT S AU Chowdhury, AS Burns, J Sen, B Mukherjee, A Yao, JH Summers, RM AF Chowdhury, Ananda S. Burns, Joseph Sen, Bhaskar Mukherjee, Arka Yao, Jianhua Summers, Ronald M. GP IEEE TI DETECTION OF PELVIC FRACTURES USING GRAPH CUTS AND CURVATURES SO 2011 18TH IEEE INTERNATIONAL CONFERENCE ON IMAGE PROCESSING (ICIP) SE IEEE International Conference on Image Processing ICIP LA English DT Proceedings Paper CT 18th IEEE International Conference on Image Processing (ICIP) CY SEP 11-14, 2011 CL Brussels, BELGIUM SP IEEE, IEEE Signal Proc Soc (SPS) DE Pelvic fracture; Graph Cut; Mean and Gaussian curvatures ID EPIDEMIOLOGY; SEGMENTATION AB Traumatic injury of the pelvis is common and potentially devastating, with pelvic fractures being a major cause of trauma patient mortality. Detection and management of pelvic injuries is challenging due to varying injury patterns and resulting complications such as hemorrhage and infection. In this paper, we investigate the application of computer-aided detection (CAD) techniques for pelvic fracture detection. We propose a fast semi-automated method of pelvic fracture detection using a combination of i) graph cuts and ii) mean and Gaussian curvatures. A fracture is modeled as a minimum cut in a weighted graph. The same fracture is alternatively modeled as a valley based on the signs of mean and Gaussian curvatures. Each of these methods, in isolation, generates false positives in addition to the true fracture. We then combine the two methods and perform a neighborhood analysis to eliminate the false positives. Experimental results indicate that proposed method is very promising. C1 [Chowdhury, Ananda S.; Sen, Bhaskar; Mukherjee, Arka] Jadavpur Univ, Dept Elect & Telecom Engn, Kolkata 700032, India. [Burns, Joseph; Yao, Jianhua; Summers, Ronald M.] NIH, Clin Ctr, Dept Radiol & Imag Sci, Bethesda, MD 20892 USA. [Burns, Joseph] Univ Calif Irvine, Dept Radiol Sci, Irvine, CA 92697 USA. RP Chowdhury, AS (reprint author), Jadavpur Univ, Dept Elect & Telecom Engn, Kolkata 700032, India. EM ananda.chowdhury@gmail.com; jburns@uci.edu; bhaskarsen.ju@gmail.com; arkamukherjee49@gmail.com; jyao@cc.nih.gov; rms@nih.gov FU Imaging Sciences Training Program; Radiology and Imaging Sciences Department; National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health; National Institutes of Health Clinical Center FX This research was supported in part by the Imaging Sciences Training Program sponsored by the Radiology and Imaging Sciences Department and the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health. This research was also supported in part by the National Institutes of Health Clinical Center. NR 12 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1522-4880 BN 978-1-4577-1303-3 J9 IEEE IMAGE PROC PY 2011 BP 1573 EP 1576 PG 4 WC Engineering, Electrical & Electronic; Imaging Science & Photographic Technology SC Engineering; Imaging Science & Photographic Technology GA BYI89 UT WOS:000298962501175 ER PT S AU Bagci, U Yao, JH Caban, J Palmore, TN Suffredini, AF Mollura, DJ AF Bagci, Ulas Yao, Jianhua Caban, Jesus Palmore, Tara N. Suffredini, Anthony F. Mollura, Daniel J. GP IEEE TI Automatic Detection of Tree-in-Bud Patterns for Computer Assisted Diagnosis of Respiratory Tract Infections SO 2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) SE IEEE Engineering in Medicine and Biology Society Conference Proceedings LA English DT Proceedings Paper CT 33rd Annual International Conference of the IEEE Engineering-in-Medicine-and-Biology-Society (EMBS) CY AUG 30-SEP 03, 2011 CL Boston, MA SP IEEE, Engn Med & Biol Soc (EMBS) ID IMAGE SEGMENTATION AB Abnormal nodular branching opacities at the lung periphery in Chest Computed Tomography (CT) are termed by radiology literature as tree-in-bud (TIB) opacities. These subtle opacity differences represent pulmonary disease in the small airways such as infectious or inflammatory bronchiolitis. Precisely quantifying the detection and measurement of TIB abnormality using computer assisted detection (CAD) would assist clinical and research investigation of this pathology commonly seen in pulmonary infections. This paper presents a novel method for automatically detecting TIB patterns based on fast localization of candidates using local scale information of the images. The proposed method combines shape index, local gradient statistics, and steerable wavelet features to automatically identify TIB patterns. Experimental results using 39 viral bronchiolitis human para-influenza (HPIV) CTs and 21 normal lung CTs achieved an overall accuracy of 89.95%. C1 [Bagci, Ulas; Mollura, Daniel J.] NIH, Ctr Infect Dis Imaging, Bldg 10, Bethesda, MD 20892 USA. [Bagci, Ulas; Yao, Jianhua; Mollura, Daniel J.] NIH, Dept Radiol & Imaging Sci, Bethesda, MD 20892 USA. [Caban, Jesus] NIH, Natl Lib Med, Bethesda, MD 20892 USA. [Palmore, Tara N.] NIH, Lab Clin Infectious Diseases, Bethesda, MD 20892 USA. [Suffredini, Anthony F.] NIH, Critical Care Med Dept, Bethesda, MD 20892 USA. RP Bagci, U (reprint author), NIH, Ctr Infect Dis Imaging, Bldg 10, Bethesda, MD 20892 USA. EM ulas.bagci@nih.gov OI Bagci, Ulas/0000-0001-7379-6829 FU Imaging Sciences Training Program (ISTP); Radiology and Imaging Sciences Department of NIH Clinical Center; National Institutes of Allergy and Infectious Diseases; National Institutes of Bio-imaging and Bioengineerin FX This research is supported in part by the Imaging Sciences Training Program (ISTP), the Center for Infectious Disease Imaging Intramural program in the Radiology and Imaging Sciences Department of the NIH Clinical Center, the Intramural Program of the National Institutes of Allergy and Infectious Diseases, and the Intramural Research Program of the National Institutes of Bio-imaging and Bioengineerin. NR 10 TC 1 Z9 1 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1557-170X BN 978-1-4244-4122-8 J9 IEEE ENG MED BIO PY 2011 BP 5096 EP 5099 PG 4 WC Engineering, Biomedical; Engineering, Electrical & Electronic SC Engineering GA BYH52 UT WOS:000298810004010 ER PT S AU Karargyris, A Antani, S Thoma, G AF Karargyris, Alexandros Antani, Sameer Thoma, George GP IEEE TI Segmenting Anatomy in Chest X-rays for Tuberculosis Screening SO 2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) SE IEEE Engineering in Medicine and Biology Society Conference Proceedings LA English DT Proceedings Paper CT 33rd Annual International Conference of the IEEE Engineering-in-Medicine-and-Biology-Society (EMBS) CY AUG 30-SEP 03, 2011 CL Boston, MA SP IEEE, Engn Med & Biol Soc (EMBS) ID RADIOGRAPHS; DIFFERENTIATION; IMAGES; CELLS AB In this paper we describe the development of a screening system for pulmonary pathologies (i.e. pneumonia, tuberculosis) application in global healthcare settings. As a first step toward this goal, the paper presents a novel approach for detecting lungs and ribs in chest radiographs. The approach is a unified method combining two detection schemes resulting in reduced cost. The novelty of our approach lies on the fact that instead of using pixel-wise techniques exclusively we used region-based features computed as wavelet features that take into consideration the orientation of anatomic structures. Initial results are described. Next steps include classification of non-rib lung regions for radiographic patterns suggesting tuberculosis infection. C1 [Karargyris, Alexandros; Antani, Sameer; Thoma, George] NIH, US Natl Lib Med, Bethesda, MD 20892 USA. RP Karargyris, A (reprint author), NIH, US Natl Lib Med, Bldg 10, Bethesda, MD 20892 USA. OI Antani, Sameer/0000-0002-0040-1387 NR 22 TC 8 Z9 8 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1557-170X BN 978-1-4244-4122-8 J9 IEEE ENG MED BIO PY 2011 BP 7779 EP 7782 PG 4 WC Engineering, Biomedical; Engineering, Electrical & Electronic SC Engineering GA BYH52 UT WOS:000298810005320 ER PT S AU Makrogiannis, S Ramachandran, R Fishbein, KW Kapogiannis, D Spencer, RG Chia, CW AF Makrogiannis, Sokratis Ramachandran, Ramona Fishbein, Kenneth W. Kapogiannis, Dimitrios Spencer, Richard G. Chia, Chee W. GP IEEE TI Towards Segmentation of the Thymus in Fat and Water Parametric MR Images SO 2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) SE IEEE Engineering in Medicine and Biology Society Conference Proceedings LA English DT Proceedings Paper CT 33rd Annual International Conference of the IEEE Engineering-in-Medicine-and-Biology-Society (EMBS) CY AUG 30-SEP 03, 2011 CL Boston, MA SP IEEE, Engn Med & Biol Soc (EMBS) ID REGENERATION AB The thymus, an organ responsible for the development, selection, and maintenance of the peripheral T-cell population, is an important regulator of the immune system. Despite its physiological significance, it has received little attention in the medical image analysis literature. In practice, the anatomical location and variable shape of this gland pose challenges both in the image acquisition and analysis processes. We present an automated method for segmenting the thymus from water and fat parametric MR images that permits further analysis of volumetrics and tissue characterization. We compute fat ratio and water ratio parametric images and introduce the use of a stochastic edge detector that is embedded in a geometric variational segmentation model. Validation experiments of the proposed algorithm against manual delineations of the thymus indicate the applicability of our approach. C1 [Makrogiannis, Sokratis; Ramachandran, Ramona; Fishbein, Kenneth W.; Kapogiannis, Dimitrios; Spencer, Richard G.; Chia, Chee W.] NIA, NIH, Baltimore, MD 21225 USA. RP Makrogiannis, S (reprint author), NIA, NIH, 3001 S Hanover St, Baltimore, MD 21225 USA. EM makrogianniss@mail.nih.gov OI Fishbein, Kenneth/0000-0002-6353-4603 NR 15 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1557-170X BN 978-1-4244-4122-8 J9 IEEE ENG MED BIO PY 2011 BP 8078 EP 8081 PG 4 WC Engineering, Biomedical; Engineering, Electrical & Electronic SC Engineering GA BYH52 UT WOS:000298810006050 ER PT S AU Venkatakrishnan, A Contreras-Vidal, JL Sandrini, M Cohen, LG AF Venkatakrishnan, Anusha Contreras-Vidal, Jose L. Sandrini, Marco Cohen, Leonardo G. GP IEEE TI Independent component analysis of resting brain activity reveals transient modulation of local cortical processing by transcranial direct current stimulation SO 2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) SE IEEE Engineering in Medicine and Biology Society Conference Proceedings LA English DT Proceedings Paper CT 33rd Annual International Conference of the IEEE Engineering-in-Medicine-and-Biology-Society (EMBS) CY AUG 30-SEP 03, 2011 CL Boston, MA SP IEEE, Engn Med & Biol Soc (EMBS) ID DC STIMULATION AB Neuroplasticity induced by transcranial direct current stimulation (tDCS) contributes to motor learning although the underlying mechanisms are incompletely understood. Here, we investigated the effects of tDCS on resting brain dynamics recorded by whole-head magnetoencephalography (MEG) pre- and up to 35 minutes post-tDCS or sham over the left primary motor cortex (M1) in healthy adults. Owing to superior temporal and spatial resolution of MEG, we sought to apply a robust, blind and data-driven analytic approach such as independent component analysis (ICA) and statistical clustering to these data to investigate potential neuroplastic effects of tDCS during resting state conditions. We found decreased alpha and increased gamma band power that outlasted the real tDCS stimulation period in a fronto-parietal motor network relative to sham. However, this method could not find differences between anodal and cathodal polarities of tDCS. These results suggest that tDCS over M1 modulates resting brain dynamics in a fronto-parietal motor network (that includes the stimulated location), indicative of within-network enhanced localized cortical processing. C1 [Venkatakrishnan, Anusha] Univ Maryland, Grad Program Neurosci & Cognit Sci, College Pk, MD 20742 USA. [Venkatakrishnan, Anusha] NINDS, Human Cort Physiol & Stroke Neurorehabilit Sect, Bethesda, MD 20892 USA. [Venkatakrishnan, Anusha] Uniformed Serv Univ Hlth Sci, Ctr Neurosci & Regenerat, Bethesda, MD 20814 USA. [Contreras-Vidal, Jose L.] Univ Maryland, Dept Kinesiol, Grad Programs Bioengn & Neurosci & Cognit Sci, College Pk, MD 20742 USA. [Sandrini, Marco] NINDS, Human Cort Physiol & Stroke Neurorehabilit Sect, Bethesda, MD 20892 USA. [Sandrini, Marco] Uniformed Serv Univ Hlth Sci, Ctr Neurosci & Regenerat Med, Bethesda, MD 20814 USA. [Cohen, Leonardo G.] NINDS, Human Cort Physiol & Stroke Neurorehabilit Sect, Bethesda, MD 20892 USA. RP Venkatakrishnan, A (reprint author), Univ Maryland, Grad Program Neurosci & Cognit Sci, College Pk, MD 20742 USA. EM venkatakrishna@ninds.nih.gov; pepeum@umd.edu; sandrinim@ninds.nih.gov; cohenl@ninds.nih.gov RI Sandrini, Marco/J-2276-2014 OI Sandrini, Marco/0000-0002-1664-5722 FU Department of Defense in the Center for Neuroscience and Regenerative Medicine, Uniformed Services University of Health Sciences, Bethesda, MD USA; Intramural Research Program of National Institute of Neurological Disorders and Stroke (NINDS), Bethesda, MD USA FX This work was supported by the Department of Defense in the Center for Neuroscience and Regenerative Medicine, Uniformed Services University of Health Sciences, Bethesda, MD USA and the Intramural Research Program of National Institute of Neurological Disorders and Stroke (NINDS), Bethesda, MD USA. NR 13 TC 6 Z9 6 U1 6 U2 8 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1557-170X BN 978-1-4244-4122-8 J9 IEEE ENG MED BIO PY 2011 BP 8102 EP 8105 PG 4 WC Engineering, Biomedical; Engineering, Electrical & Electronic SC Engineering GA BYH52 UT WOS:000298810006056 ER PT S AU Park, HS Yoon, JW Kim, J Iseki, K Hallett, M AF Park, Hyung-Soon Yoon, Jung Won Kim, Jonghyun Iseki, Kazumi Hallett, Mark GP IEEE TI Development of a VR-based Treadmill Control Interface for Gait Assessment of Patients with Parkinson's Disease SO 2011 IEEE INTERNATIONAL CONFERENCE ON REHABILITATION ROBOTICS (ICORR) SE International Conference on Rehabilitation Robotics ICORR LA English DT Proceedings Paper CT IEEE International Conference on Rehabilitation Robotics (ICORR)/International Neurorehabilitation Symposium (INRS)/International Conference on Virtual Rehabilitation (ICVR) CY JUN 27-JUL 01, 2011 CL ETH Zurich, Zurich, SWITZERLAND SP IEEE, RA, EMB, Hocoma, You Rehab, Int Soc Virtual Rehabil (ISVR), Zentrum Ambulante Rehabil, MUNDUS, RITZ HO ETH Zurich DE BWSTI (body-weight supported treadmill interface); treadmill control; virtual reality; gait assessment; freeze of gait; Parkinson's Disease ID WALKING; SPEED AB Freezing of gait (FOG) is a commonly observed phenomenon in Parkinson's disease, but its causes and mechanisms are not fully understood. This paper presents the development of a virtual reality (VR)-based body-weight supported treadmill interface (BWSTI) designed and applied to investigate FOG. The BWSTI provides a safe and controlled walking platform which allows investigators to assess gait impairments under various conditions that simulate real life. In order to be able to evoke FOG, our BWSTI employed a novel speed adaptation controller, which allows patients to drive the treadmill speed. Our interface responsively follows the subject's intention of changing walking speed by the combined use of feedback and feedforward controllers. To provide realistic visual stimuli, a three dimensional VR system is interfaced with the speed adaptation controller and synchronously displays realistic visual cues. The VR-based BWSTI was tested with three patients with PD who are known to have FOG. Visual stimuli that might cause FOG were shown to them while the speed adaptation controller adjusted treadmill speed to follow the subjects' intention. Two of the three subjects showed FOG during the treadmill walking. C1 [Park, Hyung-Soon; Yoon, Jung Won; Kim, Jonghyun] NIH, Dept Rehabil Med, Ctr Clin, Bethesda, MD 20892 USA. [Iseki, Kazumi; Hallett, Mark] NIH, Natl Inst Neurol Disorders & Stroke, Bethesda, MD 20892 USA. [Yoon, Jung Won] Gyeongsang Natl Univ, ReCAPT, Jinju, South Korea. [Yoon, Jung Won] Gyeongsang Natl Univ, Sch Mech & Aerosp Engn, Jinju, South Korea. RP Park, HS (reprint author), NIH, Dept Rehabil Med, Ctr Clin, Bethesda, MD 20892 USA. EM parkhs@cc.nih.gov FU Intramural Research Program of NINDS; Clinical Center in NIH [10-N-0009]; CNRM (Center for Neuroscience and Regenerative Medicine) program [G1707C] FX This research is supported by the Intramural Research Program of NINDS and Clinical Center in NIH (protocol number 10-N-0009) and CNRM (Center for Neuroscience and Regenerative Medicine) program (grant number G1707C). NR 15 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1945-7898 BN 978-1-4244-9862-8 J9 INT C REHAB ROBOT PY 2011 PG 5 WC Robotics; Rehabilitation SC Robotics; Rehabilitation GA BYK51 UT WOS:000299169800125 ER PT S AU Kupfer, DJ Angst, J Berk, M Dickerson, F Frangou, S Frank, E Goldstein, BI Harvey, A Laghrissi-Thode, F Leboyer, M Ostacher, MJ Sibille, E Strakowski, SM Suppes, T Tohen, M Yolken, RH Young, LT Zarate, CA AF Kupfer, David J. Angst, Jules Berk, Michael Dickerson, Faith Frangou, Sophia Frank, Ellen Goldstein, Benjamin I. Harvey, Allison Laghrissi-Thode, Fouzia Leboyer, Marion Ostacher, Michael J. Sibille, Etienne Strakowski, Stephen M. Suppes, Trisha Tohen, Mauricio Yolken, Robert H. Young, L. Trevor Zarate, Carlos A. GP Annals NY Acad Sci TI Advances in bipolar disorder: selected sessions from the 2011 International Conference on Bipolar Disorder SO ANNALS MEETING REPORTS SE Annals of the New York Academy of Sciences LA English DT Article; Proceedings Paper CT 9th International Conference on Bipolar Disorder (ICBD) CY JUN 09-11, 2011 CL Pittsburgh, PA DE bipolar disorders; medical comorbidity; neuroscience; diagnosis ID MAJOR DEPRESSIVE DISORDER; CONSENSUS COGNITIVE BATTERY; ELECTRON-TRANSPORT CHAIN; C-REACTIVE PROTEIN; PREFRONTAL CORTEX; I DISORDER; SUBTHRESHOLD BIPOLARITY; FACIAL EXPRESSIONS; FUNCTIONAL NEUROANATOMY; PSYCHIATRIC-DISORDERS AB Recently, the 9th International Conference on Bipolar Disorder (ICBD) took place in Pittsburgh, PA, June 9-11, 2011. The conference focused on a number of important issues concerning the diagnosis of bipolar disorders across the life span, advances in neuroscience, treatment strategies for bipolar disorders, early intervention, and medical comorbidity. Several of these topics were discussed in four plenary sessions. This meeting report describes the major points of each of these sessions and included (1) strategies for moving biology forward; (2) bipolar disorder and the forthcoming new DSM-5 nomenclature; (3) management of bipolar disorders-both theory and intervention, with an emphasis on the medical comorbidities; and, (4) a review of several key task force reports commissioned by the International Society for Bipolar Disorder (ISBD). C1 [Kupfer, David J.] Univ Pittsburgh, Western Psychiat Inst & Clin, Pittsburgh, PA 15213 USA. [Angst, Jules] Univ Zurich, Hosp Psychiat, Zurich, Switzerland. [Berk, Michael] Univ Melbourne, Melbourne, Vic, Australia. [Dickerson, Faith] Sheppard Pratt Hlth Syst, Baltimore, MD USA. [Frangou, Sophia] Kings Coll London, Inst Psychiat, London WC2R 2LS, England. [Goldstein, Benjamin I.; Young, L. Trevor] Univ Toronto, Fac Med, Toronto, ON, Canada. [Harvey, Allison] Univ Calif Berkeley, Berkeley, CA 94720 USA. [Laghrissi-Thode, Fouzia] F Hoffmann La Roche Ltd, Basel, Switzerland. [Leboyer, Marion] Univ Paris 12, Hop Chenevier Mondor, Creteil, France. [Ostacher, Michael J.; Suppes, Trisha] Stanford Univ, Sch Med, Palo Alto, CA 94304 USA. [Strakowski, Stephen M.] Univ Cincinnati, Acad Hlth Ctr, Cincinnati, OH USA. [Tohen, Mauricio] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Yolken, Robert H.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Zarate, Carlos A.] NIMH, Bethesda, MD 20892 USA. RP Kupfer, DJ (reprint author), Univ Pittsburgh, Western Psychiat Inst & Clin, 3811 OHara St, Pittsburgh, PA 15213 USA. EM kupferdj@upmc.edu RI Frangou, Sophia/A-2672-2013; Berk, Michael/M-7891-2013; OI Berk, Michael/0000-0002-5554-6946; Ostacher, Michael/0000-0003-0353-7535 FU AstraZeneca LP; Merck Sharp & Dohme Corporation; Bristol-Myers Squibb; Cyberonics, Inc.; Community Care Behavioral Health Organization (an affiliate of the UPMC Health Plan); Fine Foundation; Staunton Farm Foundation FX The Ninth International Conference on Bipolar Disorders was supported in part by educational grants from AstraZeneca LP, Merck Sharp & Dohme Corporation, Bristol-Myers Squibb, and Cyberonics, Inc. Funding for this conference was also made possible by contributions from the Community Care Behavioral Health Organization (an affiliate of the UPMC Health Plan), the Fine Foundation, and the Staunton Farm Foundation. NR 120 TC 11 Z9 11 U1 4 U2 6 PU BLACKWELL SCIENCE PUBL PI OXFORD PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND SN 0077-8923 BN 978-1-57331-855-6 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PY 2011 VL 1242 BP 1 EP 25 DI 10.1111/j.1749-6632.2011.06336.x PG 25 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA BZE83 UT WOS:000301290100001 PM 22191553 ER PT J AU Ke, HN Zhang, JY Akiyama, SK French, JE AF Ke, Hengning Zhang, Jennifer Y. Akiyama, Steven K. French, John E. TI BCL2 interaction with actin in vitro may inhibit cell motility by enhancing actin polymerization SO CELL ADHESION & MIGRATION LA English DT Article DE BCL2; actin polymerization; cell motility; adhesion ID MAMMARY EPITHELIAL-CELLS; TRANSGENIC MICE; ADHESION; EXPRESSION; OVEREXPRESSION; APOPTOSIS; PROMOTES; SURVIVAL; DIFFERENTIATION; LAMELLIPODIA AB In addition to its well-defined role as an antagonist in apoptosis, we propose that BCL2 may act as an intracellular suppressor of cell motility and adhesion under certain conditions. Our evidence shows that, when overexpressed in both cancer and non-cancer cells, BCL2 can form a complex with actin and gelsolin that functions to decrease gelsolin-severing activity to increase actin polymerization and, thus, suppress cell adhesive processes. The linkage between increased BCL2 and increased actin polymerization on the one hand and suppression of cell adhesion, spreading and motility on the other hand, is a novel observation that may provide a plausible explanation for why BCL2 overexpression in some tumors is correlated with improved patient survival. In addition, we have identified conditions in vitro in which F-actin polymerization can be increased while cell motility is reduced. These findings underscore the possibility that BCL2 may be involved in modulating cytoskeleton reorganization and may provide an opportunity to explore signal transduction pathways important for cell adhesion and migration and to develop small molecule therapies for suppression of cancer metastasis. C1 [French, John E.] Natl Inst Environm Hlth Sci, Host Susceptibil Branch, NIH, Res Triangle Pk, NC 27709 USA. [Akiyama, Steven K.] Natl Inst Environm Hlth Sci, Lab Mol Carcinogenesis, NIH, Res Triangle Pk, NC USA. [Ke, Hengning; Zhang, Jennifer Y.] Duke Univ, Med Ctr, Dept Dermatol, Durham, NC USA. RP French, JE (reprint author), Natl Inst Environm Hlth Sci, Host Susceptibil Branch, NIH, Res Triangle Pk, NC 27709 USA. EM french@niehs.nih.gov OI Zhang, Jennifer/0000-0002-4485-1750 FU Division of Intramural Research, NIEHS, NIH; NIAMSD, NIH [K01AR051470] FX This manuscript was supported by the Division of Intramural Research, NIEHS, NIH and by NIAMSD, NIH grant K01AR051470 awarded to Dr. Jennifer Y. Zhang. Thanks to Dr. Douglas S. Tyler, Duke University, Durham, NC for providing A2058 melanoma cell lines and to Dr. Christine Sorenson, University of Wisconsin, Madison, WI, for the generous gift of the mouse Bcl2 deficient cells. We thank Ms. Vineela Gandham for her editing of this manuscript. NR 34 TC 3 Z9 3 U1 0 U2 4 PU LANDES BIOSCIENCE PI AUSTIN PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA SN 1933-6918 J9 CELL ADHES MIGR JI Celll Adhes. Migr. PD JAN-FEB PY 2011 VL 5 IS 1 BP 6 EP 10 DI 10.4161/cam.5.1.13175 PG 5 WC Cell Biology SC Cell Biology GA 898CG UT WOS:000300712400003 PM 20716950 ER PT J AU Melgar, MF Collins, FS Sethupathy, P AF Melgar, Michael F. Collins, Francis S. Sethupathy, Praveen TI Discovery of active enhancers through bidirectional expression of short transcripts SO GENOME BIOLOGY LA English DT Article DE Transcription; pausing; naive bayes classifier; gene regulation; histone modification; enhancers; chromatin marks; CTCF ID RNA-POLYMERASE-II; EMBRYONIC STEM-CELLS; GENE-EXPRESSION; GENOME-WIDE; DROSOPHILA-MELANOGASTER; CHROMATIN STATE; GLOBAL ANALYSIS; HUMAN PROMOTERS; ORGANIZATION; RESOLUTION AB Background Long-range regulatory elements, such as enhancers, exert substantial control over tissue-specific gene expression patterns. Genome-wide discovery of functional enhancers in different cell types is important for our understanding of genome function as well as human disease etiology. Results In this study, we developed an in silico approach to model the previously reported phenomenon of transcriptional pausing, accompanied by divergent transcription, at active promoters. We then used this model for large-scale prediction of non-promoter associated bidirectional expression of short transcripts. Our predictions were significantly enriched for DNase hypersensitive sites, histone H3 lysine 27 acetylation (H3K27ac), and other chromatin marks associated with active rather than poised or repressed enhancers. We also detected modest bidirectional expression at binding sites of the CCCTC-factor (CTCF) genome-wide, particularly those that overlap H3K27ac. Conclusions Our findings indicate that the signature of bidirectional expression of short transcripts, learned from promoter-proximal transcriptional pausing, can be used to predict active long-range regulatory elements genome-wide, likely due in part to specific association of RNA polymerase with enhancer regions. C1 [Melgar, Michael F.; Collins, Francis S.] NHGRI, Genome Technol Branch, NIH, Bethesda, MD 20892 USA. [Sethupathy, Praveen] Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA. [Sethupathy, Praveen] Univ N Carolina, Carolina Ctr Genome Sci, Chapel Hill, NC 27599 USA. [Sethupathy, Praveen] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA. RP Collins, FS (reprint author), NHGRI, Genome Technol Branch, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. EM melgamoose@gmail.com; Francis.Collins@nih.gov; praveen_sethupathy@med.unc.edu FU NIH Division of Intramural Research/NHGRI [Z01-HG000024]; NIDDK/NIH [1K99DK091318-01] FX The authors thank Rachel L. Goldfeder and Peter S. Chines for generating mouse genome (mm9) mapability data, as well as Michael L. Stitzel, Michael R. Erdos, and other members of the Collins laboratory for helpful discussions, insights, and suggestions for the manuscript. This study was supported by the NIH Division of Intramural Research/NHGRI project number Z01-HG000024 (F.S.C.), and by an NIDDK/NIH K99 grant 1K99DK091318-01 (P.S.). NR 48 TC 35 Z9 36 U1 1 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1465-6906 EI 1474-760X J9 GENOME BIOL JI Genome Biol. PY 2011 VL 12 IS 11 AR R113 DI 10.1186/gb-2011-12-11-r113 PG 35 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA 904FB UT WOS:000301178400004 PM 22082242 ER PT S AU Shao, SC Hegde, RS AF Shao, Sichen Hegde, Ramanujan S. BE Schekman, R Goldstein, L Lehmann, R TI Membrane Protein Insertion at the Endoplasmic Reticulum SO ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27 SE Annual Review of Cell and Developmental Biology LA English DT Review; Book Chapter DE targeting; protein translocation ID SIGNAL RECOGNITION PARTICLE; TAIL-ANCHORED PROTEINS; TRANSMEMBRANE ALPHA-HELICES; POSITIVELY CHARGED RESIDUES; GENOME-WIDE ANALYSIS; N-TERMINAL DOMAIN; ER MEMBRANE; SACCHAROMYCES-CEREVISIAE; ESCHERICHIA-COLI; TRANSLOCATION CHANNEL AB Integral membrane proteins of the cell surface and most intracellular compartments of eukaryotic cells are assembled at the endoplasmic reticulum. Two highly conserved and parallel pathways mediate membrane protein targeting to and insertion into this organelle. The classical cotranslational pathway, utilized by most membrane proteins, involves targeting by the signal recognition particle followed by insertion via the Sec61 translocon. A more specialized posttranslational pathway, employed by many tail-anchored membrane proteins, is composed of entirely different factors centered around a cytosolic ATPase termed TRC40 or Get3. Both of these pathways overcome the same biophysical challenges of ferrying hydrophobic cargo through an aqueous milieu, selectively delivering it to one among several intracellular membranes and asymmetrically integrating its transmembrane domain(s) into the lipid bilayer. Here, we review the conceptual and mechanistic themes underlying these core membrane protein insertion pathways, the complexities that challenge our understanding, and future directions to overcome these obstacles. C1 [Shao, Sichen; Hegde, Ramanujan S.] NICHHD, Cell Biol & Metab Program, NIH, Bethesda, MD 20892 USA. [Shao, Sichen] Johns Hopkins Univ, Dept Biol, Baltimore, MD 21218 USA. RP Shao, SC (reprint author), NICHHD, Cell Biol & Metab Program, NIH, Bethesda, MD 20892 USA. EM hegde.science@gmail.com OI Shao, Sichen/0000-0003-2679-5537; Hegde, Ramanujan/0000-0001-8338-852X FU Intramural NIH HHS [ZIA HD008752-08] NR 181 TC 89 Z9 92 U1 5 U2 34 PU ANNUAL REVIEWS PI PALO ALTO PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA SN 1081-0706 BN 978-0-8243-3127-6 J9 ANNU REV CELL DEV BI JI Annu. Rev. Cell Dev.Biol. PY 2011 VL 27 BP 25 EP 56 DI 10.1146/annurev-cellbio-092910-154125 PG 32 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA BYL23 UT WOS:000299230700002 PM 21801011 ER PT S AU Szabo, R Bugge, TH AF Szabo, Roman Bugge, Thomas H. BE Schekman, R Goldstein, L Lehmann, R TI Membrane-Anchored Serine Proteases in Vertebrate Cell and Developmental Biology SO ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27 SE Annual Review of Cell and Developmental Biology LA English DT Review; Book Chapter DE homeostasis; morphogenesis; pericellular proteolysis ID EPITHELIAL SODIUM-CHANNEL; PROATRIAL NATRIURETIC PEPTIDE; EPIDERMAL BARRIER FUNCTION; IRON-DEFICIENCY ANEMIA; AUTOSOMAL RECESSIVE ICHTHYOSIS; FACTOR ACTIVATOR INHIBITOR-1; GENOME-WIDE ASSOCIATION; LUNG LIQUID CLEARANCE; NEURAL-TUBE DEFECTS; NETHERTON-SYNDROME AB Analysis of vertebrate genome sequences at the turn of the millennium revealed that a vastly larger repertoire of enzymes execute proteolytic cleavage reactions within the pericellular and extracellular environments than was anticipated from biochemical and molecular analysis. Most unexpected was the unveiling of an entire new family of structurally unique multidomain serine proteases that are anchored directly to the plasma membrane. Unlike secreted serine proteases, which function primarily in tissue repair, immunity, and nutrient uptake, these membrane-anchored serine proteases regulate fundamental cellular and developmental processes, including tissue morphogenesis, epithelial barrier function, ion and water transport, cellular iron export, and fertilization. Here the cellular and developmental biology of this fascinating new group of proteases is reviewed. Particularly highlighted is how the study of membrane-anchored serine proteases has expanded our knowledge of the range of physiological processes that require regulated proteolysis at the cell surface. C1 [Szabo, Roman; Bugge, Thomas H.] Natl Inst Dent & Craniofacial Res, Oral & Pharyngeal Canc Branch, NIH, Bethesda, MD 20892 USA. RP Szabo, R (reprint author), Natl Inst Dent & Craniofacial Res, Oral & Pharyngeal Canc Branch, NIH, Bethesda, MD 20892 USA. EM rszabo@nidcr.nih.gov; thomas.bugge@nih.gov FU Intramural NIH HHS [ZIA DE000699-12] NR 150 TC 38 Z9 38 U1 2 U2 8 PU ANNUAL REVIEWS PI PALO ALTO PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA SN 1081-0706 BN 978-0-8243-3127-6 J9 ANNU REV CELL DEV BI JI Annu. Rev. Cell Dev.Biol. PY 2011 VL 27 BP 213 EP 235 DI 10.1146/annurev-cellbio-092910-154247 PG 23 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA BYL23 UT WOS:000299230700009 PM 21721945 ER PT J AU Song, GF Ling, C AF Song, Guangfeng Ling, Chen TI Users' Attitude and Strategies in Information Management With Multiple Computers SO INTERNATIONAL JOURNAL OF HUMAN-COMPUTER INTERACTION LA English DT Article ID MEMORY; SYSTEMS; DESIGN; INTERFACES; DOCUMENTS; LOCATION; FIND AB This article reports the result of a survey study on how users utilize multiple computers in personal information management tasks. Two hundred ninety-five experienced computer users answered questions regarding the selective use of computers in three usage scenarios in managing multiple types of information: files, bookmarks, and e-mails. Results showed that users pursue simple computing environment by simplifying multiple computer configurations, avoiding distribution of information among multiple computers, and avoiding conceptual distinction of multiple computers. Selective use of a computer was based on the characteristics of the computers and the tasks to be performed. Information retrieval was still primarily done manually due to problems of memory decay and information overload. It was concluded that user attitudes and strategies in using multiple computers were characterized by reactive coping and avoidance of challenges. This article provides evidence of users' problems with multiple computers and highlights the need to support the seamless usage of multiple computers. C1 [Song, Guangfeng] NCBI, NIH, Bethesda, MD 20894 USA. [Ling, Chen] Univ Oklahoma, Sch Ind Engn, Norman, OK 73019 USA. RP Song, GF (reprint author), NCBI, NIH, 45 Ctr Dr, Bethesda, MD 20894 USA. EM gfsong@gmail.com NR 38 TC 1 Z9 1 U1 0 U2 8 PU LAWRENCE ERLBAUM ASSOC INC-TAYLOR & FRANCIS PI PHILADELPHIA PA 325 CHESTNUT STREET, STE 800, PHILADELPHIA, PA 19106 USA SN 1044-7318 J9 INT J HUM-COMPUT INT JI Int. J. Hum.-Comput. Interact. PY 2011 VL 27 IS 8 BP 762 EP 792 DI 10.1080/10447318.2011.555307 PG 31 WC Computer Science, Cybernetics; Ergonomics SC Computer Science; Engineering GA 885IE UT WOS:000299771600001 ER PT J AU Ong, TP Moreno, FS Ross, SA AF Ong, Thomas Prates Moreno, Fernando Salvador Ross, Sharon Ann TI Targeting the Epigenome with Bioactive Food Components for Cancer Prevention SO JOURNAL OF NUTRIGENETICS AND NUTRIGENOMICS LA English DT Review DE Bioactive food components; Cancer; DNA methylation; Epigenome; Histone modifications; Prevention ID INHIBITS HISTONE DEACETYLASE; CELL-CYCLE ARREST; FOLIC-ACID SUPPLEMENTATION; GLOBAL DNA HYPOMETHYLATION; POLYCOMB GROUP PROTEINS; TUMOR-SUPPRESSOR GENES; EMBRYONIC STEM-CELLS; BREAST-CANCER; DIALLYL DISULFIDE; IN-VIVO AB Epigenetic processes participate in cancer development and likely influence cancer prevention. Global DNA hypomethylation, gene promoter hypermethylation and aberrant histone post-translational modifications are hallmarks of neoplastic cells which have been associated with genomic instability and altered gene expression. Because epigenetic deregulation occurs early in carcinogenesis and is potentially reversible, intervention strategies targeting the epigenome have been proposed for cancer prevention. Bioactive food components (BFCs) with anticancer potential, including folate, polyphenols, selenium, retinoids, fatty acids, isothiocyanates and allyl compounds, influence DNA methylation and histone modification processes. Such activities have been shown to affect the expression of genes involved in cell proliferation, death and differentiation that are frequently altered in cancer. Although the epigenome represents a promising target for cancer prevention with BFCs, few studies have addressed the influence of dietary components on these mechanisms in vivo, particularly on the phenotype of humans, and thus the exact mechanisms whereby diet mediates an effect on cancer prevention remains unclear. Primary factors that should be elucidated include the effective doses and dose timing of BFCs to attain epigenetic effects. Because diet-epigenome interactions are likely to occur in utero, the impact of early-life nutrition on cancer risk programming should be further investigated. Copyright (C) 2012 S. Karger AG, Basel C1 [Ong, Thomas Prates; Moreno, Fernando Salvador] Univ Sao Paulo, Dept Alimentos & Nutr Expt, Fac Ciencias Farmaceut, Lab Diet Nutr & Canc, BR-05508900 Sao Paulo, Brazil. [Ross, Sharon Ann] NCI, Nutr Sci Res Grp, Canc Prevent Div, NIH,Dept Hlth & Human Serv, Bethesda, MD 20892 USA. RP Ong, TP (reprint author), Univ Sao Paulo, Dept Alimentos & Nutr Expt, Fac Ciencias Farmaceut, Lab Diet Nutr & Canc, Bloco 14,Av Prof Lineu Prestes 580, BR-05508900 Sao Paulo, Brazil. EM tong@usp.br RI Ong, Thomas/C-4494-2012; Moreno, Fernando/I-1943-2013 FU FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo); CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior); CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) FX Research in the Diet, Nutrition and Cancer Laboratory is supported by FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo), CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior) and CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico). NR 136 TC 29 Z9 29 U1 2 U2 15 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1661-6499 EI 1661-6758 J9 J NUTRIGENET NUTRIGE JI J. Nutrigenet. Nutrigenomics PY 2011 VL 4 IS 5 BP 275 EP 292 DI 10.1159/000334585 PG 18 WC Genetics & Heredity; Nutrition & Dietetics SC Genetics & Heredity; Nutrition & Dietetics GA 899FX UT WOS:000300802900004 PM 22353664 ER PT S AU Gainer, H Ponzio, TA Yue, CM Kawasaki, M AF Gainer, Harold Ponzio, Todd A. Yue, Chunmei Kawasaki, Makoto BE Merighi, A TI Intron-Specific Neuropeptide Probes SO NEUROPEPTIDES: METHODS AND PROTOCOLS SE Methods in Molecular Biology LA English DT Article; Book Chapter DE Pre-mRNA; Heteronuclear RNA; hn RNA; Real-time qPCR; Oxytocin; Vasopressin; Gene expression ID REAL-TIME PCR; VASOPRESSIN GENE-EXPRESSION; RAT SUPRAOPTIC NUCLEUS; CORTICOTROPIN-RELEASING HORMONE; HETERONUCLEAR RNA; MESSENGER-RNA; IN-VIVO; INSITU HYBRIDIZATION; ARGININE-VASOPRESSIN; TRANSCRIPTION AB Measurements of changes in pre-mRNA levels by intron-specific probes are generally accepted as more closely reflecting changes in gene transcription rates than are measurements of mRNA levels by exonic probes. This is, in part, because the pre-mRNAs, which include the primary transcript and various splicing intermediates located in the nucleus (also referred to as heteronuclear RNAs, or hnRNAs), are processed rapidly (with half-lives <60 min) as compared to neuropeptide mRNAs, which are then transferred to the cytoplasm and which have much longer half-lives (often over days). In this chapter, we describe the use of exon-and intron-specific probes to evaluate oxytocin (OT) and vasopressin (VP) neuropeptide gene expression by analyses of their mRNAs and hnRNAs by quantitative in situ hybridization (qISH) and also by using specific PCR primers in quantitative, real-time PCR (qPCR) procedures. C1 [Gainer, Harold; Ponzio, Todd A.] NINDS, Neurochem Lab, NIH, Bethesda, MD 20892 USA. [Kawasaki, Makoto] Univ Occupat & Environm Hlth, Sch Med, Dept Orthopaed, Kitakyushu, Fukuoka 807, Japan. [Yue, Chunmei] Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai, Peoples R China. RP Gainer, H (reprint author), NINDS, Neurochem Lab, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA. FU Intramural NIH HHS [Z99 NS999999] NR 30 TC 2 Z9 2 U1 0 U2 0 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA SN 1064-3745 BN 978-1-61779-309-7 J9 METHODS MOL BIOL JI Methods Mol. Biol. PY 2011 VL 789 BP 89 EP 110 DI 10.1007/978-1-61779-310-3_5 D2 10.1007/978-1-61779-310-3 PG 22 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA BYN65 UT WOS:000299454600005 PM 21922402 ER PT S AU Park, JJ Loh, YP AF Park, Joshua J. Loh, Y. Peng BE Merighi, A TI Visualization of Peptide Secretory Vesicles in Living Nerve Cells SO NEUROPEPTIDES: METHODS AND PROTOCOLS SE Methods in Molecular Biology LA English DT Article; Book Chapter DE Carboxypeptidase E; Brain-derived neurotrophic factor; Hippocampal neurons; Peptidergic secretory vesicles; Vesicle trafficking ID HIPPOCAMPAL-NEURONS; TRANSPORT AB Analysis of real-time movements of peptidergic vesicles in live neurons provides insight into molecular mechanism(s) supporting the activity-dependent secretion of neurotrophins and neuropeptides. We examined the effect of overexpression of exogenous peptides comprising of the cytoplasmic tail sequence of vesicular carboxypeptidase E (CPE), proposed to be involved in the mechanism of trafficking of peptidergic secretory vesicles, in live hippocampal neurons. E16 rat hippocampal neurons were transfected with the peptidergic vesicle markers, CPE C-terminally tagged with red or green fluorescent protein, or brain-derived neurotrophic factor (BDNF) tagged with green fluorescent protein, and grown on dishes specialized for real-time live cell visualization. Movements of peptidergic vesicles were imaged in a temperature-controlled chamber on a confocal inverted microscope and analyzed with respect to their velocity, displacement distance, and processivity. C1 [Park, Joshua J.] Univ Toledo, Coll Med, Toledo, OH 43606 USA. [Loh, Y. Peng] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD USA. RP Park, JJ (reprint author), Univ Toledo, Coll Med, 2801 W Bancroft St, Toledo, OH 43606 USA. FU Intramural NIH HHS NR 6 TC 3 Z9 3 U1 0 U2 1 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA SN 1064-3745 BN 978-1-61779-309-7 J9 METHODS MOL BIOL JI Methods Mol. Biol. PY 2011 VL 789 BP 137 EP 145 DI 10.1007/978-1-61779-310-3_8 D2 10.1007/978-1-61779-310-3 PG 9 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA BYN65 UT WOS:000299454600008 PM 21922405 ER PT J AU Kolenbrander, PE Periasamy, S AF Kolenbrander, Paul E. Periasamy, Saravanan BE Kolenbrander, PE TI INTERSPECIES INTERACTIONS PROMOTE MULTISPECIES COMMUNITIES SO ORAL MICROBIAL COMMUNITIES: GENOMIC INQUIRY AND INTERSPECIES COMMUNICATION LA English DT Article; Book Chapter ID GINGIVAL EPITHELIAL-CELLS; COAGGREGATION RECEPTOR POLYSACCHARIDES; ORAL MICROBIAL COMMUNITIES; INITIAL DENTAL BIOFILM; OUTER-MEMBRANE PROTEIN; PORPHYROMONAS-GINGIVALIS; FUSOBACTERIUM-NUCLEATUM; STREPTOCOCCUS-GORDONII; TANNERELLA-FORSYTHIA; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS C1 [Kolenbrander, Paul E.; Periasamy, Saravanan] Natl Inst Dent & Craniofacial Res, Oral Infect & Immun Branch, NIH, Bethesda, MD 20892 USA. RP Kolenbrander, PE (reprint author), Natl Inst Dent & Craniofacial Res, Oral Infect & Immun Branch, NIH, Bethesda, MD 20892 USA. NR 137 TC 1 Z9 1 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA BN 978-1-55581-710-7 PY 2011 BP 3 EP + PG 18 WC Dentistry, Oral Surgery & Medicine; Microbiology SC Dentistry, Oral Surgery & Medicine; Microbiology GA BYN82 UT WOS:000299465400002 ER PT J AU Palmer, RJ Kolenbrander, PE AF Palmer, Robert J., Jr. Kolenbrander, Paul E. BE Kolenbrander, PE TI SPATIOTEMPORAL ORGANIZATION OF MULTISPECIES COMMUNITIES IN THE HUMAN ORAL MICROBIOME SO ORAL MICROBIAL COMMUNITIES: GENOMIC INQUIRY AND INTERSPECIES COMMUNICATION LA English DT Article; Book Chapter ID IN-SITU HYBRIDIZATION; INITIAL DENTAL BIOFILM; STREPTOCOCCUS-MUTANS; PORPHYROMONAS-GINGIVALIS; ACTINOMYCES-NAESLUNDII; FUSOBACTERIUM-NUCLEATUM; GENE-EXPRESSION; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS; INTERGENERIC COMMUNICATION; VIRULENCE TRAITS C1 [Palmer, Robert J., Jr.; Kolenbrander, Paul E.] Natl Inst Dent & Craniofacial Res, Oral Infect & Immun Branch, NIH, Bethesda, MD 20892 USA. RP Palmer, RJ (reprint author), Natl Inst Dent & Craniofacial Res, Oral Infect & Immun Branch, NIH, Bethesda, MD 20892 USA. NR 57 TC 0 Z9 0 U1 0 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA BN 978-1-55581-710-7 PY 2011 BP 371 EP + PG 13 WC Dentistry, Oral Surgery & Medicine; Microbiology SC Dentistry, Oral Surgery & Medicine; Microbiology GA BYN82 UT WOS:000299465400026 ER PT S AU Maudsley, S Chadwick, W Wang, LY Zhou, Y Martin, B Park, SS AF Maudsley, Stuart Chadwick, Wayne Wang, Liyun Zhou, Yu Martin, Bronwen Park, Sung-Soo BE Luttrell, LM Ferguson, SSG TI Bioinformatic Approaches to Metabolic Pathways Analysis SO SIGNAL TRANSDUCTION PROTOCOLS, THIRD EDITION SE Methods in Molecular Biology LA English DT Article; Book Chapter DE Signaling; Network; Pathway; Phenotype; Receptor ID DIFFERENTIALLY EXPRESSED GENES; TANDEM MASS-SPECTROMETRY; DIETARY ENERGY-INTAKE; FALSE DISCOVERY RATE; MICROARRAY DATA; QUANTITATIVE PROTEOMICS; PROTEIN IDENTIFICATION; NONPARAMETRIC METHODS; STATISTICAL-ANALYSIS; ESCHERICHIA-COLI AB The growth and development in the last decade of accurate and reliable mass data collection techniques has greatly enhanced our comprehension of cell signaling networks and pathways. At the same time however, these technological advances have also increased the difficulty of satisfactorily analyzing and interpreting these ever-expanding datasets. At the present time, multiple diverse scientific communities including molecular biological, genetic, proteomic, bioinformatic, and cell biological, are converging upon a common endpoint, that is, the measurement, interpretation, and potential prediction of signal transduction cascade activity from mass datasets. Our ever increasing appreciation of the complexity of cellular or receptor signaling output and the structural coordination of intracellular signaling cascades has to some extent necessitated the generation of a new branch of informatics that more closely associates functional signaling effects to biological actions and even whole-animal phenotypes. The ability to untangle and hopefully generate theoretical models of signal transduction information flow from transmembrane receptor systems to physiological and pharmacological actions may be one of the greatest advances in cell signaling science. In this overview, we shall attempt to assist the navigation into this new field of cell signaling and highlight several methodologies and technologies to appreciate this exciting new age of signal transduction. C1 [Maudsley, Stuart; Chadwick, Wayne; Wang, Liyun; Zhou, Yu; Park, Sung-Soo] NIA, Receptor Pharmacol Unit, NIH, Baltimore, MD 21224 USA. [Martin, Bronwen] NIA, Metab Unit, NIH, Baltimore, MD 21224 USA. RP Maudsley, S (reprint author), NIA, Receptor Pharmacol Unit, NIH, Baltimore, MD 21224 USA. FU Intramural NIH HHS [Z01 AG000312-08] NR 60 TC 11 Z9 11 U1 0 U2 3 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA SN 1064-3745 BN 978-1-61779-159-8 J9 METHODS MOL BIOL JI Methods Mol. Biol. PY 2011 VL 756 BP 99 EP 130 DI 10.1007/978-1-61779-160-4_5 D2 10.1007/978-1-61779-160-4 PG 32 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA BYN63 UT WOS:000299454400005 PM 21870222 ER PT B AU Meleth, AD Raiji, VR Krishnadev, N Chew, EY AF Meleth, Annal D. Raiji, Veena R. Krishnadev, Nupura Chew, Emily Y. BE Ho, AC Regillo, CD TI Therapy of Nonexudative Age-Related Macular Degeneration SO AGE-RELATED MACULAR DEGENERATION DIAGNOSIS AND TREATMENT LA English DT Article; Book Chapter ID BLUE-MOUNTAINS-EYE; POLYUNSATURATED FATTY-ACIDS; RETINAL-PIGMENT EPITHELIUM; HIGH-DOSE SUPPLEMENTATION; 3RD NATIONAL-HEALTH; VITAMIN-E; BETA-CAROTENE; FOLIC-ACID; ENDOTHELIAL FUNCTION; CARDIOVASCULAR-DISEASE C1 [Meleth, Annal D.; Krishnadev, Nupura] NEI, Dept Epidemiol & Clin Applicat, NIH, Bethesda, MD 20892 USA. [Raiji, Veena R.] George Washington Univ, Dept Ophthalmol, Washington, DC USA. [Chew, Emily Y.] NEI, Div Epidemiol & Clin Applicat, NIH, Bethesda, MD 20892 USA. RP Meleth, AD (reprint author), NEI, Dept Epidemiol & Clin Applicat, NIH, 10 Ctr Dr, Bethesda, MD 20892 USA. EM echew@nei.nih.gov NR 98 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY BN 978-1-4614-0124-7 PY 2011 BP 65 EP 78 DI 10.1007/978-1-4614-0125-4_5 D2 10.1007/978-1-4614-0125-4 PG 14 WC Ophthalmology SC Ophthalmology GA BXA98 UT WOS:000295560200005 ER PT J AU Kumar, V Talisman, IJ Bukhari, O Razzaghy, J Malhotra, SV AF Kumar, Vineet Talisman, Ian Jamie Bukhari, Omar Razzaghy, Jacqueline Malhotra, Sanjay V. TI Dual role of ionic liquids as phase transfer catalyst and solvent for glycosidation reactions SO RSC ADVANCES LA English DT Article ID BETA-D-GLUCOPYRANOSIDES; ANGELICA-FURCIJUGA; CELLS; CONSTITUENTS; ADRIAMYCIN; EXTRACTION; EFFICIENT; ROOTS; SALTS AB This report describes the dual role of ionic liquids as phase transfer catalysts and reaction media in heterogeneous glycosidation reactions. Thorough study using a diverse set of ionic liquids provided insight into the relationship between ionic liquid structure and catalytic activity in these reactions. For example, glycosidation was efficient in ionic liquid 1-hexyl-3-methylimidazolium hexafluorophosphate (HxMIm.PF6), and the O- and S-glycosides were produced exclusively in moderate to good yields. As an outcome of the preliminary screen, a tailored novel ionic liquid, 1-hydroxyhexyl-3-methylimidazolium hexafluorophosphate (HOHxMIm.PF6) was rationally designed to be immiscible with water and traditional organic solvents. This provided an advantage in ionic liquid recycling and product recovery via convenient triphasic extraction. The versatility of this methodology was demonstrated through glycosidation reaction on a wide variety of substrates including phenols (17-79%), thiophenols (24-97%), chalcone (44%), and flavone (50-67%). Furthermore, this study shows that the ionic liquid could be employed for at least three runs without apparent loss in activity. C1 [Kumar, Vineet; Talisman, Ian Jamie; Bukhari, Omar; Razzaghy, Jacqueline; Malhotra, Sanjay V.] NCI, Lab Synthet Chem, SAIC Frederick Inc, Frederick, MD 21702 USA. RP Kumar, V (reprint author), NCI, Lab Synthet Chem, SAIC Frederick Inc, 1050 Boyles St, Frederick, MD 21702 USA. EM malhotrasa@mail.nih.gov FU National Cancer Institute, National Institutes of Health [HHSN261200800001E] FX The authors would like to thank the NCI Developmental Therapeutics Program. This project has been funded in whole or in part with federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261200800001E. NR 38 TC 12 Z9 12 U1 0 U2 13 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2046-2069 J9 RSC ADV JI RSC Adv. PY 2011 VL 1 IS 9 BP 1721 EP 1727 DI 10.1039/c1ra00385b PG 7 WC Chemistry, Multidisciplinary SC Chemistry GA 855JT UT WOS:000297561000014 ER PT J AU Marques, A AF Marques, Adriana BE Halperin, JJ TI Chronic Lyme Disease SO LYME DISEASE: AN EVIDENCE-BASED APPROACH SE Advances in Molecular and Cellular Microbiology LA English DT Article; Book Chapter ID PLACEBO-CONTROLLED TRIAL; SOLITARY ERYTHEMA MIGRANS; BURGDORFERI-INFECTED MICE; CHRONIC-FATIGUE-SYNDROME; IV ANTIBIOTIC-THERAPY; BORRELIA-BURGDORFERI; PERSISTENT SYMPTOMS; CEFUROXIME AXETIL; FOLLOW-UP; DOUBLE-BLIND C1 NIAID, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA. RP Marques, A (reprint author), NIAID, Lab Clin Infect Dis, NIH, 10-11N234 10 Ctr Dr, Bethesda, MD 20892 USA. NR 91 TC 1 Z9 1 U1 0 U2 2 PU CABI PUBLISHING-C A B INT PI WALLINGFORD PA CABI PUBLISHING, WALLINGFORD 0X10 8DE, OXON, ENGLAND BN 978-1-84593-804-8 J9 ADV M C M PY 2011 IS 20 BP 248 EP 258 D2 10.1079/9781845938048.0000 PG 11 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA BXP04 UT WOS:000296588500017 ER PT S AU Billings, S Kapoor, A Keil, M Wood, BJ Boctor, E AF Billings, Seth Kapoor, Ankur Keil, Matthias Wood, Bradford J. Boctor, Emad BE Dhooge, J Doyley, MM TI A hybrid surface/image based approach to facilitate ultrasound/CT registration SO MEDICAL IMAGING 2011: ULTRASONIC IMAGING, TOMOGRAPHY, AND THERAPY SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Medical Imaging - Ultrasonic Imaging, Tomography, and Therapy CY FEB 13-14, 2011 CL Lake Buena Vista, FL SP SPIE, Dynasil Corp/RMD Res, AAPM - Amer Assoc Physicists Med, DQE Instruments, Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc DE ultrasound/CT image fusion; surface registration; image registration; time-of-flight; time-of-flight calibration; Cumulative Cross Residual Entropy; Coherent Point Drift ID IMAGE REGISTRATION; SURGERY AB Registration of intra-operative ultrasound with preoperative CT is highly desirable as a navigational aid for surgeons and interventional radiologists. Image-based solutions generally achieve poor results due to substantially different image appearance of ultrasound and CT. A method is presented that uses surface information and tracked ultrasound to improve registration results. Tracked ultrasound is combined with surface and image-based registration techniques to register ultrasound to CT. Surface data is acquired using an optically tracked range sensor, for example time-of-flight camera. Range data is registered to CT using robust point-set registration; this registration provides an approximate transformation from tracker to CT coordinates. The ultrasound probe is also optically tracked. The probe position and surface-based registration provide a first estimate for the position of the ultrasound image in CT coordinates. This estimate is subsequently refined by a final image-based registration stage. Initial tests using Coherent Point Drift algorithm for registering surface data to CT show favorable results. Tests using both simulated and real time-of-flight range data have good convergence over a wide initial translation and rotation misalignment domain. Preliminary testing using time-of-flight surface data suggests that surface to CT registration may be useful as an initial guess enabling later more precise (but less robust) image based methods for registering ultrasound images to CT. We believe this method will enable image-based algorithms to robustly converge to an optimal registration solution. C1 [Billings, Seth; Kapoor, Ankur; Wood, Bradford J.] NIH, Clin Ctr, Bethesda, MD 20892 USA. RP Billings, S (reprint author), NIH, Clin Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA. RI Boctor, Emad/I-6597-2012 NR 9 TC 1 Z9 1 U1 0 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-510-6 J9 PROC SPIE PY 2011 VL 7968 AR 79680V DI 10.1117/12.878941 PG 12 WC Optics; Radiology, Nuclear Medicine & Medical Imaging SC Optics; Radiology, Nuclear Medicine & Medical Imaging GA BXL94 UT WOS:000296332300030 ER PT B AU Pinn, VW Corry, NH AF Pinn, Vivian W. Corry, Nida H. BE Meleis, AI Birch, EL Wachter, SM TI Women's Health in the Urban Community: National Institutes of Health Perspective SO WOMEN'S HEALTH AND THE WORLD'S CITIES SE City in the Twenty-First Century LA English DT Article; Book Chapter C1 [Pinn, Vivian W.] Howard Univ, Coll Med, Dept Pathol, Washington, DC 20059 USA. [Pinn, Vivian W.] Tufts Univ, Sch Med, Medford, MA 02155 USA. [Pinn, Vivian W.] Howard Univ, Sch Med, Washington, DC 20059 USA. [Pinn, Vivian W.; Corry, Nida H.] NIH, Off Res Womens Hlth, Bethesda, MD 20892 USA. [Corry, Nida H.] ABT Associates Inc, Cambridge, MA 02138 USA. RP Pinn, VW (reprint author), NIH, NIH Working Grp Women Biomed Careers, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU UNIV PENNSYLVANIA PRESS PI PHILADELPHIA PA 3905 SPRUCE STREET, PHILADELPHIA, PA 19104 USA BN 978-0-8122-4353-6 J9 CITY 21ST CENTURY PY 2011 BP 169 EP + PG 21 WC Urban Studies; Women's Studies SC Urban Studies; Women's Studies GA BWL34 UT WOS:000294189300010 ER PT J AU Fearon, T Xie, HC Cheng, JY Ning, H Zhuge, Y Miller, RW AF Fearon, Thomas Xie, Huchen Cheng, Jason Y. Ning, Holly Zhuge, Ying Miller, Robert W. TI Patient-specific CT dosimetry calculation: a feasibility study SO JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS LA English DT Article DE CT; radiation dosimetry; treatment planning system; CT organ dose ID COMPUTED-TOMOGRAPHY EXAMINATIONS; MONTE-CARLO TECHNIQUES; RADIATION-THERAPY; DOSE ESTIMATION; ANTHROPOMORPHIC PHANTOM; PEDIATRIC-PATIENTS; ORGAN; CHILDREN; ENERGY; MODELS AB Current estimation of radiation dose from computed tomography (CT) scans on patients has relied on the measurement of Computed Tomography Dose Index (CTDI) in standard cylindrical phantoms, and calculations based on mathematical representations of "standard man". Radiation dose to both adult and pediatric patients from a CT scan has been a concern, as noted in recent reports. The purpose of this study was to investigate the feasibility of adapting a radiation treatment planning system (RTPS) to provide patient-specific CT dosimetry. A radiation treatment planning system was modified to calculate patient-specific CT dose distributions, which can be represented by dose at specific points within an organ of interest, as well as organ dose-volumes (after image segmentation) for a GE Light Speed Ultra Plus CT scanner. The RTPS calculation algorithm is based on a semi-empirical, measured correction-based algorithm, which has been well established in the radiotherapy community. Digital representations of the physical phantoms (virtual phantom) were acquired with the GE CT scanner in axial mode. Thermoluminescent dosimeter (TLDs) measurements in pediatric anthropomorphic phantoms were utilized to validate the dose at specific points within organs of interest relative to RTPS calculations and Monte Carlo simulations of the same virtual phantoms (digital representation). Congruence of the calculated and measured point doses for the same physical anthropomorphic phantom geometry was used to verify the feasibility of the method. The RTPS algorithm can be extended to calculate the organ dose by calculating a dose distribution point-by-point for a designated volume. Electron Gamma Shower (EGSnrc) codes for radiation transport calculations developed by National Research Council of Canada (NRCC) were utilized to perform the Monte Carlo (MC) simulation. In general, the RTPS and MC dose calculations are within 10% of the TLD measurements for the infant and child chest scans. With respect to the dose comparisons for the head, the RTPS dose calculations are slightly higher (10%-20%) than the TLD measurements, while the MC results were within 10% of the TLD measurements. The advantage of the algebraic dose calculation engine of the RTPS is a substantially reduced computation time (minutes vs. days) relative to Monte Carlo calculations, as well as providing patient-specific dose estimation. It also provides the basis for a more elaborate reporting of dosimetric results, such as patient specific organ dose volumes after image segmentation. C1 [Fearon, Thomas] Childrens Natl Med Ctr, Dept Diagnost Imaging & Radiol, Washington, DC 20010 USA. [Fearon, Thomas] Childrens Natl Med Ctr, Childrens Res Inst, Washington, DC 20010 USA. [Fearon, Thomas] George Washington Univ, Med Ctr, Dept Radiol, Washington, DC 20037 USA. [Xie, Huchen; Cheng, Jason Y.; Ning, Holly; Zhuge, Ying; Miller, Robert W.] NCI, Radiat Oncol Branch, NIH, Bethesda, MD 20892 USA. RP Fearon, T (reprint author), Childrens Natl Med Ctr, Dept Diagnost Imaging & Radiol, 111 Michigan Ave NW, Washington, DC 20010 USA. EM tfearon@childrensnational.org FU National Cancer Institute, NIH FX The authors would like to thank GE Medical Systems for providing detailed information of the GE LightSpeed CT scanner. This research was supported by the Intramural Research Program of the National Cancer Institute, NIH. NR 66 TC 1 Z9 1 U1 1 U2 2 PU MULTIMED INC PI TORONTO PA 66 MARTIN ST, TORONTO, ON L9T 2R2, CANADA SN 1526-9914 J9 J APPL CLIN MED PHYS JI J. Appl. Clin. Med. Phys PY 2011 VL 12 IS 4 BP 196 EP 209 PG 14 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 849XS UT WOS:000297159300018 ER PT J AU Franquelim, HG De-Sousa, FF Veiga, AS Santos, NC Castanho, MARB AF Franquelim, Henri G. De-Sousa, Filipa F. Salome Veiga, A. Santos, Nuno C. Castanho, Miguel A. R. B. TI Cationic liposomes are possible drug-delivery systems for HIV fusion inhibitor sifuvirtide SO SOFT MATTER LA English DT Article ID MEMBRANES; SELECTIVITY; PROTEIN AB HIV-1 inhibitor sifuvirtide presents increased affinity for cationic dipalmitoylethyl-phosphatidylcholine (EDPPC) in contrast to viral/raft-mimicking (VRM) membranes. When associated to sifuvirtide, EDPPC-containing vesicles fuse with VRM vesicles. After fusion, the peptide co-localizes on VRM vesicles, indicating an effective delivery and concentration of sifuvirtide towards the viral and lipid raft vicinity. C1 [Franquelim, Henri G.; De-Sousa, Filipa F.; Salome Veiga, A.; Santos, Nuno C.; Castanho, Miguel A. R. B.] Univ Lisbon, Fac Med, Inst Med Mol, P-1649028 Lisbon, Portugal. [Salome Veiga, A.] NCI, Biol Chem Lab, Frederick, MD 21701 USA. RP Castanho, MARB (reprint author), Univ Lisbon, Fac Med, Inst Med Mol, Av Prof Egas Moniz, P-1649028 Lisbon, Portugal. EM macastanho@fm.ul.pt RI Santos, Nuno/N-7248-2013; OI Santos, Nuno/0000-0002-0580-0475; Veiga, Ana Salome/0000-0002-9892-2243 FU Fundacao para a Ciencia e a Tecnologia - Ministerio do Ensino e Ciencia (FCT-MES; Portugal) [SFRH/BD/39039/2007, PTDC/QUI-BIQ/104787/2008, PTDC/QUI-BIQ/112929/2009]; GAPIC (Faculdade deMedicina da Universidade de Lisboa) [201000017] FX The authors thank FusoGen (Tianjin, P. R. China) for the kind gift of sifuvirtide, and to Sonia Henriques for the support and helpful discussions. Fundacao para a Ciencia e a Tecnologia - Ministerio do Ensino e Ciencia (FCT-MES; Portugal) is acknowledged for funding (SFRH/BD/39039/2007 grant to H. G. F. and projects PTDC/QUI-BIQ/104787/2008 and PTDC/QUI-BIQ/112929/2009). F. F. D-S. thanks GAPIC (Faculdade deMedicina da Universidade de Lisboa) for grant 201000017. NR 21 TC 3 Z9 3 U1 0 U2 11 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1744-683X J9 SOFT MATTER JI Soft Matter PY 2011 VL 7 IS 23 BP 11089 EP 11092 DI 10.1039/c1sm06553j PG 4 WC Chemistry, Physical; Materials Science, Multidisciplinary; Physics, Multidisciplinary; Polymer Science SC Chemistry; Materials Science; Physics; Polymer Science GA 848DP UT WOS:000297029500007 ER PT S AU Coxon, B AF Coxon, Bruce BE Horton, D TI LAURANCE DAVID HALL 1938-2009 SO ADVANCES IN CARBOHYDRATE CHEMISTRY AND BIOCHEMISTRY, VOL 65 SE Advances in Carbohydrate Chemistry and Biochemistry LA English DT Biographical-Item; Book Chapter C1 Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD 20892 USA. RP Coxon, B (reprint author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD 20892 USA. NR 1 TC 0 Z9 0 U1 1 U2 5 PU ELSEVIER ACADEMIC PRESS INC PI SAN DIEGO PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA SN 0065-2318 BN 978-0-12-385520-6 J9 ADV CARBOHYD CHEM BI JI Adv. Carbohydr .Chem. Biochem. PY 2011 VL 65 BP 11 EP 43 DI 10.1016/B978-0-12-385520-6.00002-9 PG 33 WC Biochemistry & Molecular Biology; Chemistry, Organic SC Biochemistry & Molecular Biology; Chemistry GA BWJ53 UT WOS:000294028700002 ER PT J AU Camphausen, KA Wang, M Graves, C Corn, BW Muanza, TM Howard, SP Mahadevan, A Schultz, CJ Haas, ML Mehta, MP AF Camphausen, K. A. Wang, M. Graves, C. Corn, B. W. Muanza, T. M. Howard, S. P. Mahadevan, A. Schultz, C. J. Haas, M. L. Mehta, M. P. TI Predictive Value of Tumor Recurrence Using Urinary Vascular Endothelial Growth Factor Levels in Patients Receiving Radiation Therapy for Glioblastoma SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Meeting Abstract C1 [Camphausen, K. A.; Graves, C.] NCI, NIH, Bethesda, MD 20892 USA. [Wang, M.] RTOG Stat Ctr, Philadelphia, PA USA. [Corn, B. W.] Tel Aviv Med Ctr & Sch Med, Tel Aviv, Israel. [Muanza, T. M.] McGill Univ, Montreal, PQ, Canada. [Howard, S. P.] Univ Wisconsin Hosp, Madison, WI USA. [Mahadevan, A.] Dartmouth Hitchcock Med Ctr, Lebanon, NH 03766 USA. [Schultz, C. J.] Med Coll Wisconsin, Milwaukee, WI 53226 USA. [Haas, M. L.] Reading Hosp Med Ctr, W Reading, PA USA. [Mehta, M. P.] NW Mem Hosp, Chicago, IL 60611 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PY 2011 VL 81 IS 2 SU S BP S181 EP S181 PG 1 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 840AX UT WOS:000296411700364 ER PT J AU Horton, JA Sworder, B Kuznetsov, S Chung, E Robey, PG Citrin, DE AF Horton, J. A. Sworder, B. Kuznetsov, S. Chung, E. Robey, P. G. Citrin, D. E. TI Macrophages Mediate Bone Marrow Stromal Cell Homing to Irradiated Sites SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Meeting Abstract C1 [Horton, J. A.; Chung, E.; Citrin, D. E.] Nat Canc Inst, Rad Onc Branch, Bethesda, MD USA. [Sworder, B.; Kuznetsov, S.; Robey, P. G.] Nat Inst Dent & Craniofacial Res, Bethesda, MD USA. RI Robey, Pamela/H-1429-2011 OI Robey, Pamela/0000-0002-5316-5576 NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PY 2011 VL 81 IS 2 SU S BP S703 EP S703 PG 1 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 840AX UT WOS:000296411701529 ER PT J AU Kesarwala, AH Pfalzer, LA O'Meara, WP Stout, NL AF Kesarwala, A. H. Pfalzer, L. A. O'Meara, W. P. Stout, N. L. TI The Relationship of Post-operative Breast Radiation Therapy to Physical Function SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Meeting Abstract C1 [Kesarwala, A. H.] NCI, Bethesda, MD 20892 USA. [Pfalzer, L. A.] Univ Michigan Flint, Flint, MI USA. [O'Meara, W. P.; Stout, N. L.] Natl Naval Med Ctr, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PY 2011 VL 81 IS 2 SU S BP S216 EP S216 PG 1 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 840AX UT WOS:000296411700438 ER PT J AU Kil, W Lita, E Gordon, I Tandle, A Tofilon, P Camphausen, K AF Kil, W. Lita, E. Gordon, I. Tandle, A. Tofilon, P. Camphausen, K. TI Levetiracetam Sensitizes Glioblastoma Multiforme Cells to Temozolomide Plus Radiation Therapy SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Meeting Abstract C1 [Kil, W.; Lita, E.; Gordon, I.; Tandle, A.; Tofilon, P.; Camphausen, K.] NCI, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PY 2011 VL 81 IS 2 SU S BP S25 EP S25 PG 1 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 840AX UT WOS:000296411700049 ER PT J AU Ko, CJ Menard, C Ning, H Lita, E Smith, S Pinto, P Singh, AK Coleman, C Camphausen, K Kaushal, A AF Ko, C. J. Menard, C. Ning, H. Lita, E. Smith, S. Pinto, P. Singh, A. K. Coleman, C. Camphausen, K. Kaushal, A. TI Intrarectal Amifostine Suspension During External Beam Radiotherapy For Prostate Cancer May Protect Against Long-term Toxicity SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Meeting Abstract C1 [Ko, C. J.; Ning, H.; Lita, E.; Smith, S.; Pinto, P.; Coleman, C.; Camphausen, K.; Kaushal, A.] NCI, Bethesda, MD 20892 USA. [Menard, C.] Univ Toronto, Toronto, ON, Canada. [Singh, A. K.] Roswell Pk Canc Inst, Buffalo, NY 14263 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PY 2011 VL 81 IS 2 SU S BP S443 EP S443 PG 1 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 840AX UT WOS:000296411700913 ER PT J AU Lamart, S Morton, LM Simon, SL Curtis, RE Aleman, BMP Smith, SA Weathers, RE Stovall, M AF Lamart, S. Morton, L. M. Simon, S. L. Curtis, R. E. Aleman, B. M. P. Smith, S. A. Weathers, R. E. Stovall, M. TI Radiation Doses to the Esophagus from Radiotherapy Treatment for Breast Cancer during 1943-2001 SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Meeting Abstract C1 [Lamart, S.; Morton, L. M.; Simon, S. L.; Curtis, R. E.] NCI, NIH, Rockville, MD USA. [Aleman, B. M. P.] Netherlands Canc Inst, Amsterdam, Netherlands. [Smith, S. A.; Weathers, R. E.; Stovall, M.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PY 2011 VL 81 IS 2 SU S BP S250 EP S250 PG 1 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 840AX UT WOS:000296411700508 ER PT J AU Levendag, PC Keskin-Cambay, F Teguh, DN El-Gantiry, M Wildeman, MA de Pan, C Vikram, B Abdel-Wahab, M Rosenblatt, E AF Levendag, P. C. Keskin-Cambay, F. Teguh, D. N. El-Gantiry, M. Wildeman, M. A. de Pan, C. Vikram, B. Abdel-Wahab, M. Rosenblatt, E. TI Brachytherapy, a Highly Focused Technique for Applying High Booster Doses of Radiation. Question: Can it be of Value in Reducing the Local Relapse Rate in Advanced Cancer of the Nasopharynx? SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Meeting Abstract C1 [Levendag, P. C.; Keskin-Cambay, F.; Teguh, D. N.; de Pan, C.] Erasmus MC Daniel den Hoed Canc Ctr, NL-3075 EA Rotterdam, Netherlands. [El-Gantiry, M.] Data Ctr Cairo Data Anal Prospect Randomized Tria, Cairo, Egypt. [Wildeman, M. A.] Netherlands Canc Inst, Antoni Van Leeuwenhoek Hosp, NL-1066 CX Amsterdam, Netherlands. [Vikram, B.] NIH, Washington, WA USA. [Abdel-Wahab, M.] Data Ctr Cairo Data Anal Prospect Randomized Tria, Cairo, Egypt. [Rosenblatt, E.] IAEA, Appl Radiat Biol & Radiotherapy Div Human Hlth, A-1400 Vienna, Austria. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PY 2011 VL 81 IS 2 SU S BP S510 EP S511 PG 2 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 840AX UT WOS:000296411701128 ER PT J AU Lok, B Khan, S Mutter, R Fields, R Kraus, D Pfister, D Busam, K Brownell, I Coit, D Lee, N AF Lok, B. Khan, S. Mutter, R. Fields, R. Kraus, D. Pfister, D. Busam, K. Brownell, I. Coit, D. Lee, N. TI Selective Radiotherapy for the Treatment of Head and Neck Merkel Cell Carcinoma SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Meeting Abstract C1 [Lok, B.; Khan, S.; Mutter, R.; Fields, R.; Kraus, D.; Pfister, D.; Busam, K.; Coit, D.; Lee, N.] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. [Brownell, I.] NCI, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PY 2011 VL 81 IS 2 SU S BP S544 EP S545 PG 2 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 840AX UT WOS:000296411701196 ER PT J AU Matsuo, M Miwa, K Shinoda, J Tanaka, O Krishna, M AF Matsuo, M. Miwa, K. Shinoda, J. Tanaka, O. Krishna, M. TI Impact of C11-methionine Positron Emission Tomography (PET) for Malignant Glioma in Radiation Therapy: Is C11-methionine PET a superior to Magnetic Resonance Imaging? SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Meeting Abstract C1 [Matsuo, M.; Krishna, M.] NIH, Bethesda, MD 20892 USA. [Matsuo, M.; Miwa, K.; Tanaka, O.] Kizawa Mem Hosp, Minokanio, Japan. [Shinoda, J.] Chubu Med Ctr Prolonged Traumat Brain Dysfunct, Minokamo, Japan. NR 0 TC 0 Z9 0 U1 2 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PY 2011 VL 81 IS 2 SU S BP S182 EP S182 PG 1 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 840AX UT WOS:000296411700365 ER PT J AU Mulhern, JP Fitzgerald, T Bosch, W Chen, J Siegel, E Jamijian, A O'Meara, E Freymann, J Kirby, J Purdy, J AF Mulhern, J. P. Fitzgerald, T. Bosch, W. Chen, J. Siegel, E. Jamijian, A. O'Meara, E. Freymann, J. Kirby, J. Purdy, J. TI Bioinformatics Support of Cross Correlation of Images with RT Objects and Clinical Meta-data SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Meeting Abstract C1 [Mulhern, J. P.; Jamijian, A.] Booz Allen Hamilton, Rockville, MD USA. [Fitzgerald, T.] Univ Massachusetts, Amherst, MA 01003 USA. [Bosch, W.] Washington Univ, St Louis, MO USA. [Chen, J.; Siegel, E.] Univ Maryland, Baltimore, MD 21201 USA. [O'Meara, E.] Radiat Therapy Oncol Grp, Philadelphia, PA USA. [Freymann, J.; Kirby, J.] NCI, Canc Imaging Program, Rockville, MD USA. [Purdy, J.] Univ Calif Davis, Davis, CA 95616 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PY 2011 VL 81 IS 2 SU S BP S160 EP S160 PG 1 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 840AX UT WOS:000296411700321 ER PT J AU Niu, Y Han-Oh, S Parke, WC Yi, B Yu, CX AF Niu, Y. Han-Oh, S. Parke, W. C. Yi, B. Yu, C. X. TI Geometric and Dosimetric Verification of Four-dimensional Intensity Modulated Arc Therapy SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Meeting Abstract C1 [Niu, Y.; Yi, B.; Yu, C. X.] Univ Maryland, Sch Med, Dept Radiat Oncol, Baltimore, MD 21201 USA. [Niu, Y.; Parke, W. C.] George Washington Univ, Dept Phys, Washington, DC 20052 USA. [Han-Oh, S.] NCI, NIH, Bethesda, MD 20892 USA. NR 2 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PY 2011 VL 81 IS 2 SU S BP S894 EP S894 PG 1 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 840AX UT WOS:000296411701928 ER PT J AU Ray, GL Baidoo, K Keller, L Milenic, D Brechbiel, M AF Ray, G. L. Baidoo, K. Keller, L. Milenic, D. Brechbiel, M. TI Pre-clinical Evaluation of Lu-177-Labeled Trastuzumab Targeting HER2 for Radioimmunotherapeutic and Radioimmunodiagnostic Applications SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Meeting Abstract C1 [Ray, G. L.; Baidoo, K.; Keller, L.; Milenic, D.; Brechbiel, M.] NCI, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PY 2011 VL 81 IS 2 SU S BP S743 EP S743 PG 1 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 840AX UT WOS:000296411701611 ER PT J AU Rosenblatt, E El-Gantiry, M Elattar, I Afiane, M Benjafaar, N Abubaker, S Chansilpa, Y Vikram, B Abdel-Wahab, M Levendag, P AF Rosenblatt, E. El-Gantiry, M. Elattar, I. Afiane, M. Benjafaar, N. Abubaker, S. Chansilpa, Y. Vikram, B. Abdel-Wahab, M. Levendag, P. TI Brachytherapy Boost in Loco-regionally Advanced Nasopharyngeal Carcinoma: A Prospective Randomized Trial of the International Atomic Energy Agency SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Meeting Abstract C1 [Rosenblatt, E.; Abdel-Wahab, M.] IAEA, A-1400 Vienna, Austria. [El-Gantiry, M.; Elattar, I.] Cairo Univ, Natl Canc Inst, Cairo, Egypt. [Afiane, M.] Ctr Hosp Univ Mustafa CHU, Ctr Pierre & Marie Curie, Dept Radiotherapie, Algiers, Algeria. [Benjafaar, N.] Inst Natl Oncol, Rabat, Morocco. [Abubaker, S.] Pakistan Atom Energy Commiss, Inst Nucl Med & Oncol, Lahore, Pakistan. [Chansilpa, Y.] Mahidol Univ, Fac Med, Siriraj Hosp, Bangkok 10700, Thailand. [Vikram, B.] NCI, Bethesda, MD 20892 USA. [Abdel-Wahab, M.] Cleveland Clin, Taussig Comprehens Canc Ctr, Cleveland, OH 44106 USA. [Levendag, P.] Erasmus Univ, Rotterdam, Netherlands. NR 0 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PY 2011 VL 81 IS 2 SU S BP S4 EP S5 PG 2 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 840AX UT WOS:000296411700008 ER PT J AU Simone, B Simone, CB Dan, TD Ly, D Lita, E Smith, S Levine, S Folio, L Simone, NL AF Simone, B. Simone, C. B. Dan, T. D. Ly, D. Lita, E. Smith, S. Levine, S. Folio, L. Simone, N. L. TI Lack of Radiation-induced Pulmonary Toxicity 25 years after Treatment with Breast Conservation Therapy or Mastectomy for Early-stage Breast Cancer: Results from the NCI Randomized Trial SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Meeting Abstract C1 [Simone, B.] Touro Coll Osteopath Med, New York, NY USA. [Simone, B.; Simone, C. B.; Dan, T. D.; Ly, D.; Lita, E.; Smith, S.; Simone, N. L.] NCI, Radiat Oncol Branch, Bethesda, MD 20892 USA. [Levine, S.] NHLBI, Cardiovasc & Pulm Branch, Bethesda, MD 20892 USA. [Folio, L.] Clin Res Ctr, Bethesda, MD USA. [Simone, N. L.] Thomas Jefferson Univ Hosp, Dept Radiat Oncol, Philadelphia, PA 19107 USA. NR 0 TC 1 Z9 1 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PY 2011 VL 81 IS 2 SU S BP S6 EP S7 PG 2 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 840AX UT WOS:000296411700012 ER PT J AU Simone, B Simone, CB Dan, TD Ly, D Lita, E Smith, S Levine, S Folio, L Simone, NL AF Simone, B. Simone, C. B. Dan, T. D. Ly, D. Lita, E. Smith, S. Levine, S. Folio, L. Simone, N. L. TI Long-term Update of US GI Intergroup RTOG 98-11 Phase III Trial for Anal Carcinoma: Concurrent Chemoradiation with 5-FU-mitomycin Yields Better Disease-free and Overall Survival than 5-FU-cisplatin SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Meeting Abstract C1 [Simone, B.] Touro Coll Osteopath Med, New York, NY USA. [Simone, B.; Simone, C. B.; Dan, T. D.; Ly, D.; Lita, E.; Smith, S.; Simone, N. L.] NCI, Radiat Oncol Branch, Bethesda, MD 20892 USA. [Levine, S.] NHLBI, Cardiovasc & Pulm Branch, Bethesda, MD 20892 USA. [Folio, L.] Clin Res Ctr, Bethesda, MD USA. [Simone, N. L.] Thomas Jefferson Univ Hosp, Dept Radiat Oncol, Philadelphia, PA 19107 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PY 2011 VL 81 IS 2 SU S BP S5 EP S6 PG 2 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 840AX UT WOS:000296411700010 ER PT J AU Simone, CB Stewart, DM Lita, E Kreitman, RJ Conlon, K Janik, JE Morris, JC Kaushal, A AF Simone, C. B. Stewart, D. M. Lita, E. Kreitman, R. J. Conlon, K. Janik, J. E. Morris, J. C. Kaushal, A. TI Radiation Therapy for Management of Patients with HTLV-1-associated Adult T-cell Leukemia/Lymphoma SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Meeting Abstract C1 [Simone, C. B.; Stewart, D. M.; Lita, E.; Kreitman, R. J.; Conlon, K.; Janik, J. E.; Morris, J. C.; Kaushal, A.] NCI, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PY 2011 VL 81 IS 2 SU S BP S630 EP S631 PG 2 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 840AX UT WOS:000296411701375 ER PT J AU Simone, CB O'Connell, J Both, S Mansueti, JR Christodouleas, J Deville, C McDonough, J Vapiwala, N Efstathiou, JA Bekelman, JA AF Simone, C. B. O'Connell, J. Both, S. Mansueti, J. R. Christodouleas, J. Deville, C. McDonough, J. Vapiwala, N. Efstathiou, J. A. Bekelman, J. A. TI Para-aortic Nodal Clinical Target Volume Delineation in the Era of Particle Therapy SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Meeting Abstract C1 [Simone, C. B.] NCI, Bethesda, MD 20892 USA. [O'Connell, J.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Both, S.; Christodouleas, J.; Deville, C.; McDonough, J.; Vapiwala, N.; Bekelman, J. A.] Hosp Univ Penn, Philadelphia, PA 19104 USA. [Mansueti, J. R.] Natl Naval Med Ctr, Bethesda, MD USA. [Efstathiou, J. A.] Massachusetts Gen Hosp, Boston, MA 02114 USA. RI Deville, Curtiland/B-2819-2013 OI Deville, Curtiland/0000-0003-4846-6486 NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PY 2011 VL 81 IS 2 SU S BP S451 EP S451 PG 1 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 840AX UT WOS:000296411701001 ER PT J AU Youn, P Howlader, N Milano, MT Constine, LS Travis, LB AF Youn, P. Howlader, N. Milano, M. T. Constine, L. S. Travis, L. B. TI Long-term Cause-specific Mortality of Adolescent and Young Adult (AYA) Survivors of Bone and Soft Tissue Sarcoma (STS): A Population-based Study SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Meeting Abstract C1 [Youn, P.; Milano, M. T.; Constine, L. S.; Travis, L. B.] Univ Rochester, Sch Med & Dent, Dept Radiat Oncol, Rochester, NY USA. [Howlader, N.] NCI, Surveillance Res Program, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PY 2011 VL 81 IS 2 SU S BP S137 EP S138 PG 2 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 840AX UT WOS:000296411700277 ER PT J AU Biassoni, R Coligan, JE Moretta, L AF Biassoni, Roberto Coligan, John E. Moretta, Lorenzo TI Natural Killer Cells in Healthy and Diseased Subjects SO JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY LA English DT Editorial Material ID CLASS-I MOLECULES; HLA-C; RECEPTORS; RECOGNITION; CLONING; MOUSE; LYSIS; SELF C1 [Biassoni, Roberto; Moretta, Lorenzo] Inst Giannina Gaslini, Dept Expt Med, I-16147 Genoa, Italy. [Coligan, John E.] NIAID, Receptor Cell Biol Sect, Immunogenet Lab, NIH, Rockville, MD 20852 USA. RP Biassoni, R (reprint author), Inst Giannina Gaslini, Dept Expt Med, I-16147 Genoa, Italy. EM robertobiassoni@ospedale-gaslini.ge.it NR 33 TC 0 Z9 0 U1 0 U2 0 PU HINDAWI PUBLISHING CORPORATION PI NEW YORK PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA SN 1110-7243 J9 J BIOMED BIOTECHNOL JI J. Biomed. Biotechnol. PY 2011 AR 795251 DI 10.1155/2011/795251 PG 4 WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental SC Biotechnology & Applied Microbiology; Research & Experimental Medicine GA 845JP UT WOS:000296819100001 ER PT J AU Monsurro, V Marincola, FM AF Monsurro, Vladia Marincola, Francesco M. TI Microarray Analysis for a Comprehensive Immunological-Status Evaluation during Cancer Vaccine Immune Monitoring SO JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY LA English DT Review ID CD8(+) T-CELLS; IMMUNIZATION; IMMUNOTHERAPY; LYMPHOCYTES; MELANOMA AB Anticancer immune responses can be enhanced by immune intervention that promotes complex biological mechanisms involving several cellular populations. The classical immune monitoring for biological-based cancer clinical trials is often based on single-cell analysis. However, the overall effect could be lost by such a reductionist approach explaining the lack of correlation among clinical and immunological endpoints often reported. Microarray technology could give the possibility of studying in a multiparametric setting the immune therapy effects. The application of microarray is leading to an improved understanding of the immune responses to tumor immunotherapy. In fact, analysis of cancer vaccine-induced host responses using microarrays is proposed as valuable alternative to the standard cell-based methods. This paper shows successful examples of how high-throughput gene expression profiling contributed to the understanding of anticancer immune responses during biological therapy, introducing as well the integrative platforms that allow the network analysis in molecular biology studies. C1 [Monsurro, Vladia] Univ Verona, Sch Med, Dept Pathol & Diagnost, I-37100 Verona, Italy. [Monsurro, Vladia] Azienda Osped Univ Integrata, Verona, Italy. [Marincola, Francesco M.] NIH, Infect Dis & Immunogenet Sect, Dept Transfus Med, Ctr Clin, Bethesda, MD 20892 USA. RP Monsurro, V (reprint author), Univ Verona, Sch Med, Dept Pathol & Diagnost, I-37100 Verona, Italy. EM vmonsurro@gmail.com FU AIRC; Italian Ministry of Health FX The authors are thankful to Dr. Silvia Coin and Miss Svjetlana Raus for help in proofreading the paper. V. Monsurro was financed by grants from AIRC and Italian Ministry of Health and SC is recipient of an Italian Ministry of Health fellowship. NR 19 TC 2 Z9 2 U1 0 U2 0 PU HINDAWI PUBLISHING CORPORATION PI NEW YORK PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA SN 1110-7243 J9 J BIOMED BIOTECHNOL JI J. Biomed. Biotechnol. PY 2011 AR 307297 DI 10.1155/2011/307297 PG 4 WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental SC Biotechnology & Applied Microbiology; Research & Experimental Medicine GA 845HS UT WOS:000296814200001 ER PT J AU Leiva-Salcedo, E Coddou, C Rodriguez, FE Penna, A Lopez, X Neira, T Fernandez, R Imarai, M Rios, M Escobar, J Montoya, M Huidobro-Toro, JP Escobar, A Acuna-Castillo, C AF Leiva-Salcedo, Elias Coddou, Claudio Rodriguez, Felipe E. Penna, Antonello Lopez, Ximena Neira, Tanya Fernandez, Ricardo Imarai, Monica Rios, Miguel Escobar, Jorge Montoya, Margarita Pablo Huidobro-Toro, J. Escobar, Alejandro Acuna-Castillo, Claudio TI Lipopolysaccharide Inhibits the Channel Activity of the P2X7 Receptor SO MEDIATORS OF INFLAMMATION LA English DT Article ID RAT SUBMANDIBULAR-GLAND; P2X(7) RECEPTOR; BACTERIAL LIPOPOLYSACCHARIDE; PORE FORMATION; TOLL-LIKE; SIGNAL-TRANSDUCTION; NLRP3 INFLAMMASOME; IL-1-BETA RELEASE; DANGER SIGNAL; CA2+ INFLUX AB The purinergic P2X7 receptor (P2X7R) plays an important role during the immune response, participating in several events such as cytokine release, apoptosis, and necrosis. The bacterial endotoxin lipopolysaccharide (LPS) is one of the strongest stimuli of the immune response, and it has been shown that P2X7R activation can modulate LPS-induced responses. Moreover, a C-terminal binding site for LPS has been proposed. In order to evaluate if LPS can directly modulate the activity of the P2X7R, we tested several signaling pathways associated with P2X7R activation in HEK293 cells that do not express the TLR-4 receptor. We found that LPS alone was unable to induce any P2X7R-related activity, suggesting that the P2X7R is not directly activated by the endotoxin. On the other hand, preapplication of LPS inhibited ATP-induced currents, intracellular calcium increase, and ethidium bromide uptake and had no effect on ERK activation in HEK293 cells. In splenocytes-derived T-regulatory cells, in which ATP-induced apoptosis is driven by the P2X7R, LPS inhibited ATP-induced apoptosis. Altogether, these results demonstrate that LPS modulates the activity of the P2X7R and suggest that this effect could be of physiological relevance. C1 [Rodriguez, Felipe E.; Lopez, Ximena; Neira, Tanya; Imarai, Monica; Rios, Miguel; Montoya, Margarita; Acuna-Castillo, Claudio] Univ Santiago Chile USACH, Dept Biol, Fac Quim & Biol, Santiago, Chile. [Rodriguez, Felipe E.; Lopez, Ximena; Neira, Tanya; Imarai, Monica; Rios, Miguel; Montoya, Margarita; Acuna-Castillo, Claudio] Univ Santiago Chile USACH, Ctr Biotecnol Acuicola, Santiago, Chile. [Leiva-Salcedo, Elias; Penna, Antonello] Univ Chile, Fac Med, Celula Inst Ciencias Biomed, Ctr Fondap Estudios Mol, Santiago, Chile. [Coddou, Claudio] NICHD, Sect Cellular Signaling, PDN, Bethesda, MD USA. [Fernandez, Ricardo] Univ Andres Bello, Fac Ciencias Biol, Santiago, Chile. [Fernandez, Ricardo] Univ Andres Bello, Fac Med, Santiago, Chile. [Escobar, Jorge] PUCV, Fac Ciencias, Inst Quim, Valparaiso, Chile. [Pablo Huidobro-Toro, J.] Pontificia Univ Catolica Chile, Fac Ciencias Biol, Ctr Regulac Celular & Patol JV Luco, Santiago, Chile. [Pablo Huidobro-Toro, J.] Pontificia Univ Catolica Chile, Fac Ciencias Biol, Dept Fisiol, Santiago, Chile. [Escobar, Alejandro] Univ Chile, Fac Odontol, Dept Ciencias Basicas & Comunitarias, Santiago, Chile. [Acuna-Castillo, Claudio] Univ Santiago Chile USACH, Fac Ciencias Med, Santiago, Chile. RP Acuna-Castillo, C (reprint author), Univ Santiago Chile USACH, Dept Biol, Fac Quim & Biol, Santiago, Chile. EM claudio.acuna@usach.cl RI Escobar, Alejandro/I-2775-2013 FU FONDECYT [11070117]; DICYT USACH; PBCT; Center for Molecular Studies of the Cell, FONDAP [15010006]; National Institutes of Health National Institute of Child Health and Human Development; J. V. Luco Center for Cell Regulation and Pathology FX The authors thank Dr. Stanko Stojilkovic and Dr. Andres Stutzin for the critical review of this paper, Dra Marcela Hermoso for TLR-4 antibody, Dr. Jaime Eugenin for A74003, Manuela Jimenez, Felipe Reyes, Belgica Villegas, Yohana Labra, Carolina Beltran, and Gino Nardocci for technical assistance. This work was funded by FONDECYT 11070117, DICYT USACH, and PBCT. A. Penna and E. leiva. Salcedo were funded by the Center for Molecular Studies of the Cell, FONDAP 15010006. C. Coddou was funded by the Intramural Research Program of the National Institutes of Health National Institute of Child Health and Human Development. J. P. Huidobro-Toro was supported by the J. V. Luco Center for Cell Regulation and Pathology; the Millennium Institute for Fundamental and Applied Biology (MIFAB) also contributed to the Center's funding. This work is in memory of Alfonso Salinas, Ricardo Castillo and Ruth Quiroz I. Special thanks go to Mr. George Montgomery for proofreading the paper. E. Leiva-Salcedo, C. Coddou, and F. E. Rodriguez contributed equally to this work. NR 59 TC 3 Z9 3 U1 0 U2 12 PU HINDAWI PUBLISHING CORPORATION PI NEW YORK PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA SN 0962-9351 J9 MEDIAT INFLAMM JI Mediat. Inflamm. PY 2011 AR 152625 DI 10.1155/2011/152625 PG 12 WC Cell Biology; Immunology SC Cell Biology; Immunology GA 845JL UT WOS:000296818700001 ER PT S AU Antani, S Xue, ZY Long, LR Bennett, D Ward, S Thoma, GR AF Antani, Sameer Xue, Zhiyun Long, L. Rodney Bennett, Deborah Ward, Sarah Thoma, George R. BE Boonn, WW Liu, BJ TI Is there a need for biomedical CBIR systems in clinical practice? Outcomes from a usability study SO MEDICAL IMAGING 2011: ADVANCED PACS-BASED IMAGING INFORMATICS AND THERAPEUTIC APPLICATIONS SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Medical Imaging - Advanced PACS-based Imaging Informatics and Therapeutic Applications CY FEB 16-17, 2011 CL Lake Buena Vista, FL SP SPIE, Dynasil Corp/RMD Res, AAPM - Amer Assoc Physicists Med, DQE Instruments, Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc DE content-based image retrieval; usability study; medical image analysis system; uterine cervix image AB Articles in the literature routinely describe advances in Content Based Image Retrieval (CBIR) and its potential for improving clinical practice, biomedical research and education. Several systems have been developed to address particular needs, however, surprisingly few are found to be in routine practical use. Our collaboration with the National Cancer Institute (NCI) has identified a need to develop tools to annotate and search a collection of over 100,000 cervigrams and related, anonymized patient data. One such tool developed for a projected need for retrieving similar patient images is the prototype CBIR system, called CervigramFinder, which retrieves images based on the visual similarity of particular regions on the cervix. In this article we report the outcomes from a usability study conducted at a primary meeting of practicing experts. We used the study to not only evaluate the system for software errors and ease of use, but also to explore its "user readiness", and to identify obstacles that hamper practical use of such systems, in general. Overall, the participants in the study found the technology interesting and bearing great potential; however, several challenges need to be addressed before the technology can be adopted. C1 [Antani, Sameer; Xue, Zhiyun; Long, L. Rodney; Bennett, Deborah; Ward, Sarah; Thoma, George R.] NIH, Natl Lib Med, Bethesda, MD 20892 USA. RP Antani, S (reprint author), NIH, Natl Lib Med, Bldg 10, Bethesda, MD 20892 USA. OI Antani, Sameer/0000-0002-0040-1387 NR 11 TC 1 Z9 1 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-509-0 J9 PROC SPIE PY 2011 VL 7967 AR 796708 DI 10.1117/12.878268 PG 7 WC Optics; Radiology, Nuclear Medicine & Medical Imaging SC Optics; Radiology, Nuclear Medicine & Medical Imaging GA BXL91 UT WOS:000296329700006 ER PT J AU Chun, JH Pike, VW AF Chun, Joong-Hyun Pike, Victor W. TI Single-step radiosyntheses of no-carrier-added [F-18]benzaldehydes and [F-18]benzyl halides from [F-18]fluoride ion and diaryliodonium salt precursors SO JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS LA English DT Meeting Abstract ID ROUTE C1 [Chun, Joong-Hyun; Pike, Victor W.] NIMH, Mol Imaging Branch, NIH, Bethesda, MD 20892 USA. NR 6 TC 1 Z9 1 U1 1 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0362-4803 J9 J LABELLED COMPD RAD JI J. Label. Compd. Radiopharm. PY 2011 VL 54 SU 1 BP S482 EP S482 PG 1 WC Biochemical Research Methods; Chemistry, Medicinal; Chemistry, Analytical SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry GA 833RC UT WOS:000295901600482 ER PT J AU Chun, JH Morse, CL Chin, FT Pike, VW AF Chun, Joong-Hyun Morse, Cheryl L. Chin, Frederick T. Pike, Victor W. TI No-carrier-added radiosyntheses of [F-18]fluoroarenes from diaryl sulfoxides and [F-18]fluoride ion SO JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS LA English DT Meeting Abstract C1 [Chun, Joong-Hyun; Morse, Cheryl L.; Pike, Victor W.] NIMH, Mol Imaging Branch, NIH Bethesda, Bethesda, MD 20892 USA. [Chin, Frederick T.] Stanford Univ, Dept Radiol, Sch Med, MIPS, Stanford, CA 94305 USA. NR 4 TC 1 Z9 1 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0362-4803 J9 J LABELLED COMPD RAD JI J. Label. Compd. Radiopharm. PY 2011 VL 54 SU 1 BP S70 EP S70 PG 1 WC Biochemical Research Methods; Chemistry, Medicinal; Chemistry, Analytical SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry GA 833RC UT WOS:000295901600071 ER PT J AU Donohue, SR Terry, G Zoghbi, SS Innis, RB Halldin, C Pike, VW AF Donohue, Sean R. Terry, Garth Zoghbi, Sami S. Innis, Robert B. Halldin, Christer Pike, Victor W. TI A new chemotype of CB1 receptor PET radioligand with fast brain kinetics SO JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS LA English DT Meeting Abstract C1 [Donohue, Sean R.; Terry, Garth; Zoghbi, Sami S.; Innis, Robert B.; Pike, Victor W.] NIMH, Mol Imaging Branch, Bethesda, MD 20892 USA. [Donohue, Sean R.; Halldin, Christer] Karolinska Inst, Dept Clin Neurosci, Psychiat Sect, Stockholm, Sweden. NR 2 TC 0 Z9 0 U1 0 U2 2 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0362-4803 J9 J LABELLED COMPD RAD JI J. Label. Compd. Radiopharm. PY 2011 VL 54 SU 1 BP S280 EP S280 PG 1 WC Biochemical Research Methods; Chemistry, Medicinal; Chemistry, Analytical SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry GA 833RC UT WOS:000295901600280 ER PT J AU Falguni, B Wu, HT Li, CH Shi, ZD Agnieszka, S Gary, LG AF Falguni, Basuli Wu Haitao Li Changhui Shi Zhen-Dan Agnieszka, Sulima Gary, Griffiths L. TI A First Synthesis of [F-18]Lapatinib: A Potential Tracer for Positron Emission Tomographic Imaging of ErbB1/ErbB2 Tyrosine Kinase Activity SO JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS LA English DT Meeting Abstract C1 [Falguni, Basuli; Wu Haitao; Li Changhui; Shi Zhen-Dan; Agnieszka, Sulima; Gary, Griffiths L.] NHLBI, Imaging Probe Dev Ctr, NIH, Rockville, MD USA. NR 1 TC 0 Z9 0 U1 0 U2 2 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0362-4803 J9 J LABELLED COMPD RAD JI J. Label. Compd. Radiopharm. PY 2011 VL 54 SU 1 BP S474 EP S474 PG 1 WC Biochemical Research Methods; Chemistry, Medicinal; Chemistry, Analytical SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry GA 833RC UT WOS:000295901600474 ER PT J AU Jagoda, E Bhadrasetty, V Lang, LX Williams, M Histed, S Kramer-Marek, G Marik, J Tinianow, J Merchant, M Szajek, L Paik, C Bottaro, D Choyke, P AF Jagoda, Elaine Bhadrasetty, Veerendra Lang Lixin Williams, Mark Histed, Stephanie Kramer-Marek Gabriela Marik, Jan Tinianow, Jeff Merchant, Mark Szajek, Lawrence Paik, Chang Bottaro, Donald Choyke, Peter TI Comparison of [Zr-89] and [Br-76] labeled MetMAb, a one-armed monoclonal antibody targeting the Met receptor tyrosine kinase (Met), in human gastric carcinoma (MKN-45) and glioblastoma (U87 MG) cells and xenografts SO JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS LA English DT Meeting Abstract C1 [Jagoda, Elaine; Bhadrasetty, Veerendra; Williams, Mark; Histed, Stephanie; Kramer-Marek Gabriela; Choyke, Peter] NCI, Mol Imaging Program, NIH Bethesda, Bethesda, MD 20892 USA. [Lang Lixin] NIBIB, Radiochem Grp, NIH, Bethesda, MD USA. [Marik, Jan; Tinianow, Jeff; Merchant, Mark] Genentech Inc, San Francisco, CA USA. [Szajek, Lawrence] NIH, PET Dept, CC, Bethesda, MD 20892 USA. [Paik, Chang] NIH, NMD, Rad&IS, CC, Bethesda, MD 20892 USA. [Bottaro, Donald] NCI, Urol Oncol Branch, NIH, Bethesda, MD 20892 USA. RI Bottaro, Donald/F-8550-2010 OI Bottaro, Donald/0000-0002-5057-5334 NR 2 TC 1 Z9 1 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0362-4803 J9 J LABELLED COMPD RAD JI J. Label. Compd. Radiopharm. PY 2011 VL 54 SU 1 BP S172 EP S172 PG 1 WC Biochemical Research Methods; Chemistry, Medicinal; Chemistry, Analytical SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry GA 833RC UT WOS:000295901600172 ER PT J AU Kang, CM Lee, I Yoon, KY Yi, KY Yoo, SE Lin, X Chen, XY Kim, JY Choe, YS AF Kang, Choong Mo Lee, Iljung Yoon, Kwang Yup Yi, Kyu Yang Yoo, Sung-eun Lin Xin Chen Xiaoyuan Kim, Jung Young Choe, Yearn Seong TI Evaluation of KR-31831, an angiogenesis inhibitor using Cu-64-DOTA-VEGF(121) SO JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS LA English DT Meeting Abstract C1 [Kang, Choong Mo; Lee, Iljung; Yoon, Kwang Yup; Choe, Yearn Seong] Sungkyunkwan Univ, Samsung Med Ctr, Seoul, South Korea. [Yi, Kyu Yang; Yoo, Sung-eun] KRICT, Taejon, South Korea. [Lin Xin; Chen Xiaoyuan] NIBIB, NIH, Bethesda, MD USA. [Kim, Jung Young] KIRAMS, Seoul, South Korea. NR 2 TC 0 Z9 0 U1 0 U2 3 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0362-4803 J9 J LABELLED COMPD RAD JI J. Label. Compd. Radiopharm. PY 2011 VL 54 SU 1 BP S133 EP S133 PG 1 WC Biochemical Research Methods; Chemistry, Medicinal; Chemistry, Analytical SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry GA 833RC UT WOS:000295901600134 ER PT J AU Kiesewetter, DO Gao, HK Niu, G Ma, Y Ahn, JM Chen, XY AF Kiesewetter, Dale O. Gao Haokao Niu Gang Ma Ying Ahn Jung-Mo Chen Xiaoyuan TI Evaluation of a peptide ligand for targeting of GLP-1R in vivo SO JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS LA English DT Meeting Abstract ID RECEPTOR C1 [Kiesewetter, Dale O.; Gao Haokao; Niu Gang; Ma Ying; Chen Xiaoyuan] Natl Inst Biomed Imaging & Bioengn, Lab Mol Imaging & Nanomed, NIH, Bethesda, MD USA. [Gao Haokao] Fourth Mil Med Univ, Dept Cardiol, Xian 710032, Peoples R China. [Ahn Jung-Mo] Univ Texas Dallas, Dept Chem, Dallas, TX 75230 USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0362-4803 J9 J LABELLED COMPD RAD JI J. Label. Compd. Radiopharm. PY 2011 VL 54 SU 1 BP S29 EP S29 PG 1 WC Biochemical Research Methods; Chemistry, Medicinal; Chemistry, Analytical SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry GA 833RC UT WOS:000295901600030 ER PT J AU Lang, LX Li, WH Ma, Y Niu, G Kiesewetter, DO Chen, XY AF Lang Lixin Li Weihua Ma Ying Niu Gang Kiesewetter, Dale O. Chen Xiaoyuan TI [F-18]-N-succinimidyl 4-fluoromethylbenzoate labeled RGDyK dimer for imaging alpha(v)beta(3) integrin expression SO JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS LA English DT Meeting Abstract C1 [Lang Lixin; Li Weihua; Ma Ying; Niu Gang; Kiesewetter, Dale O.; Chen Xiaoyuan] Natl Inst Biomed Imaging & Bioengn, Lab Mol Imaging & Nanomed, NIH, Bethesda, MD USA. [Li Weihua] Harbin Med Coll, Affiliated Hosp 4, Dept Med Imaging & Nucl Med, Harbin, Peoples R China. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0362-4803 J9 J LABELLED COMPD RAD JI J. Label. Compd. Radiopharm. PY 2011 VL 54 SU 1 BP S205 EP S205 PG 1 WC Biochemical Research Methods; Chemistry, Medicinal; Chemistry, Analytical SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry GA 833RC UT WOS:000295901600205 ER PT J AU Lang, LX Li, WH Guo, N Ma, Y Niu, G Kiesewetter, DO Chen, XY AF Lang Lixin Li Weihua Guo Ning Ma Ying Niu Gang Kiesewetter, Dale O. Chen Xiaoyuan TI Comparison study of [F-18]FAl-NOTA-PRGD2, [F-18]-FPPRDG2 and [Ga-68]-NOTA-PRGD2 for PET imaging of U87MG xenograft model SO JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS LA English DT Meeting Abstract C1 [Lang Lixin; Li Weihua; Guo Ning; Ma Ying; Niu Gang; Kiesewetter, Dale O.; Chen Xiaoyuan] Natl Inst Biomed Imaging & Bioengn, Lab Mol Imaging & Nanomed, NIH, Bethesda, MD USA. [Li Weihua] Harbin Med Coll, Affiliated Hosp 4, Dept Med Imaging & Nucl Med, Harbin, Peoples R China. NR 4 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0362-4803 J9 J LABELLED COMPD RAD JI J. Label. Compd. Radiopharm. PY 2011 VL 54 SU 1 BP S88 EP S88 PG 1 WC Biochemical Research Methods; Chemistry, Medicinal; Chemistry, Analytical SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry GA 833RC UT WOS:000295901600089 ER PT J AU Li, WH Lang, LX Ma, Y Niu, G Kiesewetter, DO Chen, XY AF Li Weihua Lang Lixin Ma Ying Niu Gang Kiesewetter, Dale O. Chen Xiaoyuan TI [F-18]-labeled c-Met binding peptides for tumor imaging SO JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS LA English DT Meeting Abstract C1 [Li Weihua; Lang Lixin; Ma Ying; Niu Gang; Kiesewetter, Dale O.; Chen Xiaoyuan] Natl Inst Biomed Imaging & Bioengn, Lab Mol Imaging & Nanomed, NIH, Bethesda, MD USA. [Li Weihua] Harbin Med Coll, Affiliated Hosp 4, Dept Med Imaging & Nucl Med, Harbin, Peoples R China. NR 3 TC 0 Z9 0 U1 1 U2 2 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0362-4803 J9 J LABELLED COMPD RAD JI J. Label. Compd. Radiopharm. PY 2011 VL 54 SU 1 BP S206 EP S206 PG 1 WC Biochemical Research Methods; Chemistry, Medicinal; Chemistry, Analytical SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry GA 833RC UT WOS:000295901600206 ER PT J AU Mathe, D Horvath, I Szigeti, K Donohue, SR Gulyas, B Agoston, D Palkovits, M Freund, TF Ledent, C Pike, VW Halldin, C AF Mathe, Domokos Horvath, Ildiko Szigeti, Krisztian Donohue, Sean R. Gulyas, Balazs Agoston, Denes Palkovits, Miklos Freund, Tamas F. Ledent, Catherine Pike, Victor W. Halldin, Christer TI In vivo SPECT and ex vivo autoradiographic imaging of the CB1 receptor radioligand [I-125]SD7015 in mouse brain SO JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS LA English DT Meeting Abstract C1 [Mathe, Domokos; Horvath, Ildiko; Szigeti, Krisztian] CROmed Res Ltd, Budapest, Hungary. [Donohue, Sean R.; Pike, Victor W.] NIMH, NIH, Bethesda, MD 20892 USA. [Gulyas, Balazs; Agoston, Denes; Halldin, Christer] Karolinska Inst, Stockholm, Sweden. [Palkovits, Miklos] Semmelweis Univ, Dept Anat, H-1085 Budapest, Hungary. [Freund, Tamas F.] Inst Expt Med HAS, Budapest, Hungary. [Ledent, Catherine] Univ Libre Brussels, IRIBHM, Brussels, Belgium. RI Palkovits, Miklos/F-2707-2013 NR 1 TC 0 Z9 0 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0362-4803 J9 J LABELLED COMPD RAD JI J. Label. Compd. Radiopharm. PY 2011 VL 54 SU 1 BP S295 EP S295 PG 1 WC Biochemical Research Methods; Chemistry, Medicinal; Chemistry, Analytical SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry GA 833RC UT WOS:000295901600295 ER PT J AU Pandey, MK Belanger, AP Bhattacharyya, F Wang, SY DeGrado, TR AF Pandey, Mukesh K. Belanger, Anthony P. Bhattacharyya, Falguni Wang, Shuyan DeGrado, Timothy R. TI Radiotracer Evaluation of Fatty Acid Oxidation (FAO) in Skeletal Muscle in Rats: Effects of Muscle Stimulation and Acute CPT-1 Inhibition SO JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS LA English DT Meeting Abstract C1 [Pandey, Mukesh K.; Belanger, Anthony P.; Wang, Shuyan; DeGrado, Timothy R.] Brigham & Womens Hosp, Boston, MA 02115 USA. [Pandey, Mukesh K.; Belanger, Anthony P.; Wang, Shuyan; DeGrado, Timothy R.] Harvard Univ, Sch Med, Boston, MA USA. [Bhattacharyya, Falguni] NIH, Bethesda, MD 20892 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0362-4803 J9 J LABELLED COMPD RAD JI J. Label. Compd. Radiopharm. PY 2011 VL 54 SU 1 BP S146 EP S146 PG 1 WC Biochemical Research Methods; Chemistry, Medicinal; Chemistry, Analytical SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry GA 833RC UT WOS:000295901600147 ER PT J AU Reid, AE Kim, SW Seinner, B Hooker, J Ferrieri, R Babst, B Fowler, JS AF Reid, Alicia E. Kim, Sung Won Seinner, Brienne Hooker, Jacob Ferrieri, Richard Babst, Benjamin Fowler, Joanna S. TI C-11 labeling of the auxin (3-indolyl[1-C-11]acetic acid) and its derivatives from gramine for PET imaging of transport and signaling in plants SO JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS LA English DT Meeting Abstract C1 [Reid, Alicia E.] CUNY Medgar Evers Coll, Brooklyn, NY 11973 USA. [Kim, Sung Won] NIAAA, Bethesda, MD USA. [Seinner, Brienne] U Missouri, Columbia, MO USA. [Hooker, Jacob] Martinos Ctr, Boston, MA USA. [Ferrieri, Richard; Babst, Benjamin; Fowler, Joanna S.] Brookhaven Natl Lab, Upton, NY USA. NR 3 TC 1 Z9 1 U1 0 U2 2 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0362-4803 J9 J LABELLED COMPD RAD JI J. Label. Compd. Radiopharm. PY 2011 VL 54 SU 1 BP S25 EP S25 PG 1 WC Biochemical Research Methods; Chemistry, Medicinal; Chemistry, Analytical SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry GA 833RC UT WOS:000295901600026 ER PT J AU Seo, YJ Lisa, M Kang, Y Kim, SW Hooker, J Reid, AE Haggarty, S Volkow, N Fowler, JS AF Seo, Young Jun Lisa, Muench Kang, Yeona Kim, Sung Won Hooker, Jacob Reid, Alicia E. Haggarty, Stephen Volkow, Nora Fowler, Joanna S. TI The rational design and development of C-11 labeled PET radiotracers for histone deacetylase in the central nervous system SO JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS LA English DT Meeting Abstract ID BRAIN C1 [Seo, Young Jun; Kang, Yeona; Fowler, Joanna S.] Brookhaven Natl Lab, Upton, NY 11973 USA. [Lisa, Muench; Kim, Sung Won; Volkow, Nora] NIAAA, Bethesda, MD USA. [Hooker, Jacob] Martinos Ctr, Boston, MA USA. [Reid, Alicia E.] CUNY Medgar Evers Coll, Brooklyn, NY 11225 USA. [Haggarty, Stephen] Harvard Univ, Sch Med, Boston, MA USA. [Volkow, Nora] NIDA, Bethesda, MD 20892 USA. NR 3 TC 0 Z9 0 U1 0 U2 3 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0362-4803 J9 J LABELLED COMPD RAD JI J. Label. Compd. Radiopharm. PY 2011 VL 54 SU 1 BP S315 EP S315 PG 1 WC Biochemical Research Methods; Chemistry, Medicinal; Chemistry, Analytical SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry GA 833RC UT WOS:000295901600315 ER PT J AU Li, K Zhang, HW Xie, HC Liang, Y Wang, XH Ito, Y AF Li, Kang Zhang, Hongwu Xie, Huichun Liang, Yong Wang, Xiaohong Ito, Yoichiro TI PREPARATIVE ISOLATION AND PURIFICATION OF FIVE FLAVONOIDS FROM POGOSTEMON CABLIN BENTH BY HIGH-SPEED COUNTERCURRENT CHROMATOGRAPHY AND PREPARATIVE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY SO JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES LA English DT Article DE flavones; flavanones; flavonoid; high-speed countercurrent chromatography; pogostemon cablin (Blanco) Benth; preparative HPLC; two-phase solvent system AB High-speed countercurrent chromatography (HSCCC) and preparative high-performance liquid chromatography (prep-HPLC) were successively used for the separation of pogostone and four flavonoids from Pogostemon cablin (Blanco) Benth. An efficient HSCCC separation was achieved on a two-phase solvent system composed of n-hexane-ethyl acetate-methanol-water (11: 5: 11: 5, v/v/v/v). Three well-separated peaks were obtained in the HSCCC chromatogram. The first and the second fractions each contained two flavonoids that were further separated by preparative HPLC. Consequently, the separation yielded 11.5 mg of 4',5-Dihydroxy-3',7-dimethoxyflavanone at a purity of 99%, 20.3 mg of 5-Hydroxy-7,3',4'-trimethoxyflavanone at a purity of 98%, 18 mg of 5,4'-Dihydroxy-3,7,3'-trimethoxyflavone at a purity of 96%, and 8 mg of 5-Hydroxy-3,7,4'-tetramethoxyflavone at a purity of 98%. The third HSCCC fraction yielded 18.5 mg of pogostone at a purity of 95%. The chemical structures of these compounds were identified by ESI-MSn, H-1-NMR, and C-13-NMR. C1 [Ito, Yoichiro] NHLBI, Bioseparat Technol Lab, Biochem & Biophys Ctr, NIH, Bethesda, MD 20892 USA. [Li, Kang; Zhang, Hongwu] Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou, Guangdong, Peoples R China. [Xie, Huichun; Liang, Yong; Wang, Xiaohong] S China Normal Univ, Sch Chem & Environm, Guangzhou, Guangdong, Peoples R China. RP Ito, Y (reprint author), NHLBI, Bioseparat Technol Lab, Biochem & Biophys Ctr, NIH, Bldg 10,Room 8N230,10 Ctr Dr, Bethesda, MD 20892 USA. EM itoy2@mail.nih.gov FU National Natural Science Foundation for Young Scholars of China [30801515] FX This work was supported by the National Natural Science Foundation for Young Scholars of China (Grant No. 30801515). NR 15 TC 7 Z9 8 U1 2 U2 20 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1082-6076 J9 J LIQ CHROMATOGR R T JI J. Liq. Chromatogr. Relat. Technol. PY 2011 VL 34 IS 15 BP 1617 EP 1629 DI 10.1080/10826076.2011.580486 PG 13 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 837UV UT WOS:000296231000012 PM 21949473 ER PT J AU Kish, LB Khatri, SP Bezrukov, SM Peper, F Gingl, Z Horvath, T AF Kish, Laszlo B. Khatri, Sunil P. Bezrukov, Sergey M. Peper, Ferdinand Gingl, Zoltan Horvath, Tamas TI Noise-based Deterministic Logic and Computing: a Brief Survey SO INTERNATIONAL JOURNAL OF UNCONVENTIONAL COMPUTING LA English DT Article; Proceedings Paper CT 4th International Workshop on Natural Computing (IWNC) CY SEP 23-25, 2009 CL Himeji Int Exchange Ctr, Himeji, JAPAN SP Natl Inst Informat & Commun Technol (NICT), Osaka Elect Commun Univ (OECU), Univ Hyogo (UH), Himeji City, Support Ctr Adv Telecommunicat Technol Res, Soc Instrument & Control Engn HO Himeji Int Exchange Ctr DE Noise-based computing; Logic circuits; Error rate; Energy efficiency; Noise in Brain ID ENERGY; SUPERPOSITION; SPIKES; STATES AB A short survey is provided about our recent explorations of the young topic of noise-based logic. After outlining the motivation behind noise-based computation schemes, we present a short summary of our ongoing efforts in the introduction, development and design of several noise-based deterministic multivalued logic schemes and elements. In particular, we describe classical, instantaneous, continuum, spike and random-telegraph-signal based schemes with applications such as circuits that emulate the brain's functioning and string verification via a slow communication channel. C1 [Kish, Laszlo B.; Khatri, Sunil P.] Texas A&M Univ, Dept Elect & Comp Engn, College Stn, TX 77843 USA. [Bezrukov, Sergey M.] NICHD, Lab Phys & Struct Biol, Program Phys Biol, NIH, Bethesda, MD 20892 USA. [Peper, Ferdinand] Natl Inst Informat & Commun Technol, Kobe, Hyogo 6512492, Japan. [Gingl, Zoltan] Univ Szeged, Dept Tech Informat, H-6720 Szeged, Hungary. [Horvath, Tamas] Univ Bonn, Dept Comp Sci, D-5300 Bonn, Germany. [Horvath, Tamas] Schloss Birlinghoven, Fraunhofer IAIS, D-53754 St Augustin, Germany. RP Kish, LB (reprint author), Texas A&M Univ, Dept Elect & Comp Engn, College Stn, TX 77843 USA. EM Laszlo.Kish@ece.tamu.edu RI Gingl, Zoltan/E-8262-2011 OI Gingl, Zoltan/0000-0001-6570-2685 NR 20 TC 0 Z9 0 U1 1 U2 3 PU OLD CITY PUBLISHING INC PI PHILADELPHIA PA 628 NORTH 2ND ST, PHILADELPHIA, PA 19123 USA SN 1548-7199 J9 INT J UNCONV COMPUT JI Int. J. Unconv. Comput. PY 2011 VL 7 IS 1-2 SI SI BP 101 EP 113 PG 13 WC Computer Science, Theory & Methods SC Computer Science GA 835ZE UT WOS:000296075000008 ER PT J AU Olivier, KN AF Olivier, Kenneth N. TI NEW THOUGHTS ABOUT NONTUBERCULOUS MYCOBACTERIA INFECTIONS IN CF SO PEDIATRIC PULMONOLOGY LA English DT Meeting Abstract ID CYSTIC-FIBROSIS; PREVALENCE; DISEASE; FEATURES C1 [Olivier, Kenneth N.] NIAID, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA. NR 17 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 8755-6863 EI 1099-0496 J9 PEDIATR PULM JI Pediatr. Pulmonol. PY 2011 SU 34 BP 209 EP 211 PG 3 WC Pediatrics; Respiratory System SC Pediatrics; Respiratory System GA 835YA UT WOS:000296071800079 ER PT S AU Ghosh, P Antani, S Long, LR Thoma, GR AF Ghosh, Payel Antani, Sameer Long, L. Rodney Thoma, George R. BE Olive, M Solomonides, T TI Review of Medical Image Retrieval Systems and Future Directions SO 2011 24TH INTERNATIONAL SYMPOSIUM ON COMPUTER-BASED MEDICAL SYSTEMS (CBMS) SE IEEE International Symposium on Computer-Based Medical Systems LA English DT Proceedings Paper CT 24th International Symposium on Computer-Based Medical Systems (CBMS) CY JUN 27-30, 2011 CL Univ W England, Bristol, ENGLAND SP IEEE, IEEE Engn Med & Biol Soc (EMB), British Comp Soc, Bristol Branch, ACM, IFIP HO Univ W England ID SEARCH; ENGINE AB This paper presents a review of online systems for content-based medical image retrieval (CBIR). The objective of this review is to evaluate the capabilities and gaps in these systems and to determine ways of improving relevance of multi-modal (text and image) information retrieval in the iMedline system, being developed at the National Library of Medicine (NLM). Seven medical information retrieval systems: Figuresearch, BioText, GoldMiner, Yale Image Finder, Yottalook, Image Retrieval for Medical Applications (IRMA), and iMedline have been evaluated here using the system of gaps defined in [1]. Not all of these systems take advantage of the visual information contained in biomedical literature as figures and illustrations. However, all attempt to extract metadata about the image from the full-text of the articles and retrieve figures/images in response to a query. iMedline aims to advance the state-of-the-art in multimodal information retrieval by unifying image and text features in computing relevance. We discuss the shortcomings of these current systems and discuss future directions and next steps in iMedline toward context-based medical image retrieval. C1 [Ghosh, Payel; Antani, Sameer; Long, L. Rodney; Thoma, George R.] NIH, US Natl Lib Med, Bethesda, MD 20852 USA. RP Ghosh, P (reprint author), NIH, US Natl Lib Med, Bethesda, MD 20852 USA. EM ghoshp3@mail.nih.gov; santani@mail.nih.gov; rlong@mail.nih.gov; gthoma@mail.nih.gov NR 9 TC 0 Z9 0 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1063-7125 BN 978-1-4577-1190-9 J9 COMP MED SY PY 2011 PG 6 WC Computer Science, Information Systems; Computer Science, Interdisciplinary Applications SC Computer Science GA BWZ98 UT WOS:000295472700058 ER PT S AU Rahman, MM Antani, SK Thoma, GR AF Rahman, Md Mahmudur Antani, Sameer K. Thoma, George R. BE Olive, M Solomonides, T TI Biomedical CBIR using "Bag of Keypoints" in a Modified Inverted Index SO 2011 24TH INTERNATIONAL SYMPOSIUM ON COMPUTER-BASED MEDICAL SYSTEMS (CBMS) SE IEEE International Symposium on Computer-Based Medical Systems LA English DT Proceedings Paper CT 24th International Symposium on Computer-Based Medical Systems (CBMS) CY JUN 27-30, 2011 CL Univ W England, Bristol, ENGLAND SP IEEE, IEEE Engn Med & Biol Soc (EMB), British Comp Soc, Bristol Branch, ACM, IFIP HO Univ W England ID FEATURES AB This paper presents a "bag of keypoints" based medical image retrieval approach to cope with a large variety of visually different instances under the same category or modality. Keypoint similarities in the codebook are computed using a quadratic similarity measure. The codebook is implemented using a topology preserving Self Organizing Map (SOM) which represents images as sparse feature vectors and an inverted index is created on top of this to facilitate efficient retrieval. In addition, to increase the retrieval effectiveness, query expansion is performed by exploiting the similarities between the keypoints based on analyzing the local neighborhood structure of the SOM generated codebook. The search is thus query-specific and restricted to a sub-space spanned only by the original and expanded keypoints of the query images. A systematic evaluation of retrieval results on a biomedical image collection of 5000 biomedical images of different modalities, body parts, and orientations shows a halving in computation time (efficiency) and 10% to 15% improvement in precision at each recall level (effectiveness) when compared to individual color, texture, edge-related features. C1 [Rahman, Md Mahmudur; Antani, Sameer K.; Thoma, George R.] NIH, US Natl Lib Med, Bethesda, MD 20892 USA. RP Rahman, MM (reprint author), NIH, US Natl Lib Med, Bldg 10, Bethesda, MD 20892 USA. NR 12 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1063-7125 BN 978-1-4577-1190-9 J9 COMP MED SY PY 2011 PG 6 WC Computer Science, Information Systems; Computer Science, Interdisciplinary Applications SC Computer Science GA BWZ98 UT WOS:000295472700052 ER PT S AU Xue, ZY Long, LR Antani, S Thoma, GR AF Xue, Zhiyun Long, L. Rodney Antani, Sameer Thoma, George R. BE Olive, M Solomonides, T TI Spine x-ray image retrieval using partial vertebral boundaries SO 2011 24TH INTERNATIONAL SYMPOSIUM ON COMPUTER-BASED MEDICAL SYSTEMS (CBMS) SE IEEE International Symposium on Computer-Based Medical Systems LA English DT Proceedings Paper CT 24th International Symposium on Computer-Based Medical Systems (CBMS) CY JUN 27-30, 2011 CL Univ W England, Bristol, ENGLAND SP IEEE, IEEE Engn Med & Biol Soc (EMB), British Comp Soc, Bristol Branch, ACM, IFIP HO Univ W England AB The anterior osteophyte (AO) is a bony spur on the vertebra and is symptomatic of osteo-arthritis of the spine. We present advances in our research into matching vertebral boundaries based on pathological (severity) and visual similarity. Proposed image retrieval methods are based on partial shape matching (PSM) that use landmarks along sagittal vertebral outlines that are consistent with those used by medical experts. Besides the two PSM methods that are improved algorithms of our previously developed methods, a new PSM method that is based on a simple but effective localized shape feature is proposed. The methods are evaluated and tested on a dataset of 856 segmented vertebrae and their performance is compared using precision-recall and average precision graphs. The best approaches are combined and integrated into our Web-based Spine Pathology & Image Retrieval System (SPIRS). C1 [Xue, Zhiyun; Long, L. Rodney; Antani, Sameer; Thoma, George R.] NIH, Natl Lib Med, Bethesda, MD 20892 USA. RP Xue, ZY (reprint author), NIH, Natl Lib Med, Bethesda, MD 20892 USA. EM xuez@mail.nih.gov; rlong@mail.nih.gov; santani@mail.nih.gov; gthoma@mail.nih.gov NR 8 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1063-7125 BN 978-1-4577-1190-9 J9 COMP MED SY PY 2011 PG 6 WC Computer Science, Information Systems; Computer Science, Interdisciplinary Applications SC Computer Science GA BWZ98 UT WOS:000295472700062 ER PT J AU Baker, SG Lindeman, KS Kramer, BS AF Baker, Stuart G. Lindeman, Karen S. Kramer, Barnett S. TI Clarifying the Role of Principal Stratification in the Paired Availability Design SO INTERNATIONAL JOURNAL OF BIOSTATISTICS LA English DT Article DE principal stratification; causal inference; paired availability design ID EPIDURAL ANALGESIA; IDENTIFICATION; STATISTICS; INFERENCE; TRIALS AB The paired availability design for historical controls postulated four classes corresponding to the treatment (old or new) a participant would receive if arrival occurred during either of two time periods associated with different availabilities of treatment. These classes were later extended to other settings and called principal strata. Judea Pearl asks if principal stratification is a goal or a tool and lists four interpretations of principal stratification. In the case of the paired availability design, principal stratification is a tool that falls squarely into Pearl's interpretation of principal stratification as "an approximation to research questions concerning population averages." We describe the paired availability design and the important role played by principal stratification in estimating the effect of receipt of treatment in a population using data on changes in availability of treatment. We discuss the assumptions and their plausibility. We also introduce the extrapolated estimate to make the generalizability assumption more plausible. By showing why the assumptions are plausible we show why the paired availability design, which includes principal stratification as a key component, is useful for estimating the effect of receipt of treatment in a population. Thus, for our application, we answer Pearl's challenge to clearly demonstrate the value of principal stratification. C1 [Baker, Stuart G.; Kramer, Barnett S.] Natl Inst Hlth, Bethesda, MD 20892 USA. [Lindeman, Karen S.] Johns Hopkins Med Inst, Baltimore, MD USA. RP Baker, SG (reprint author), Natl Inst Hlth, Bethesda, MD 20892 USA. NR 16 TC 2 Z9 2 U1 0 U2 0 PU BERKELEY ELECTRONIC PRESS PI BERKELEY PA 2809 TELEGRAPH AVENUE, STE 202, BERKELEY, CA 94705 USA SN 1557-4679 J9 INT J BIOSTAT JI Int. J. Biostat. PY 2011 VL 7 IS 1 AR 25 DI 10.2202/1557-4679.1338 PG 12 WC Mathematical & Computational Biology; Statistics & Probability SC Mathematical & Computational Biology; Mathematics GA 832FX UT WOS:000295789600025 PM 21686085 ER PT J AU Kukush, A Shklyar, S Masiuk, S Likhtarov, I Kovgan, L Carroll, RJ Bouville, A AF Kukush, Alexander Shklyar, Sergiy Masiuk, Sergii Likhtarov, Illya Kovgan, Lina Carroll, Raymond J. Bouville, Andre TI Methods for Estimation of Radiation Risk in Epidemiological Studies Accounting for Classical and Berkson Errors in Doses SO INTERNATIONAL JOURNAL OF BIOSTATISTICS LA English DT Article DE Berkson measurement error; Chornobyl accident; classical measurement error; estimation of radiation risk; full maximum likelihood estimating procedure; regression calibration; SIMEX estimator; uncertainties in thyroid dose ID CHERNOBYL THYROID CANCERS; QUASI-SCORE ESTIMATOR; NEVADA TEST-SITE; UNCERTAINTY ANALYSIS; UKRAINE; ACCIDENT; MODELS; DOSIMETRY; FALLOUT AB With a binary response Y, the dose-response model under consideration is logistic in flavor with pr(Y=1 vertical bar D) = R (1+R)(-1), R =lambda(0) + EAR D, where lambda(0) is the baseline incidence rate and EAR is the excess absolute risk per gray. The calculated thyroid dose of a person i is expressed as D(i)(mes) = f(i)Q(i)(mes)/M(i)(mes). Here, Q(i)(mes) is the measured content of radioiodine in the thyroid gland of person i at time t(mes), M(i)(mes) is the estimate of the thyroid mass, and f(i) is the normalizing multiplier. The Q(i) and M(i) are measured with multiplicative errors V(i)(Q) and V(i)(M), so that Q(i)(mes) = Q(i)(tr)V(i)(Q) (this is classical measurement error model) and M(i)(tr) = M(i)(mes)V(i)(M) (this is Berkson measurement error model). Here, Q(i)(tr) is the true content of radioactivity in the thyroid gland, and M(i)(tr) is the true value of the thyroid mass. The error in f(i) is much smaller than the errors in (Q(i)(mes), M(i)(mes)) and ignored in the analysis. By means of Parametric Full Maximum Likelihood and Regression Calibration (under the assumption that the data set of true doses has lognormal distribution), Nonparametric Full Maximum Likelihood, Nonparametric Regression Calibration, and by properly tuned SIMEX method we study the influence of measurement errors in thyroid dose on the estimates of lambda(0) and EAR. The simulation study is presented based on a real sample from the epidemiological studies. The doses were reconstructed in the framework of the Ukrainian-American project on the investigation of Post-Chernobyl thyroid cancers in Ukraine, and the underlying subpolulation was artificially enlarged in order to increase the statistical power. The true risk parameters were given by the values to earlier epidemiological studies, and then the binary response was simulated according to the dose-response model. C1 [Carroll, Raymond J.] Texas A&M Univ, College Stn, TX 77843 USA. [Bouville, Andre] NCI, NIH, DHHS, Bethesda, MD 20892 USA. FU U.S. National Cancer Institute; Radiation Protection Institute ATS of Ukraine; Swedish Institute [SI-01424/2007]; National Cancer Institute [CA57030]; King Abdullah University of Science and Technology (KAUST) [KUSCI-016-04] FX This work was supported by funds from the U.S. National Cancer Institute and the Radiation Protection Institute ATS of Ukraine. The authors also want to thank their colleges from the Institute of Endocrinology and Metabolism AMS of Ukraine and the Radiation Protection Institute ATS of Ukraine who contributed to the preparation of the results presented in the paper. Alexander Kukush is supported by the Swedish Institute grant SI-01424/2007. Carroll's research was supported by a grant from the National Cancer Institute (CA57030). This publication is based in part on work supported by Award Number KUSCI-016-04, made by King Abdullah University of Science and Technology (KAUST). NR 30 TC 6 Z9 6 U1 1 U2 5 PU BERKELEY ELECTRONIC PRESS PI BERKELEY PA 2809 TELEGRAPH AVENUE, STE 202, BERKELEY, CA 94705 USA SN 1557-4679 J9 INT J BIOSTAT JI Int. J. Biostat. PY 2011 VL 7 IS 1 AR 15 DI 10.2202/1557-4679.1281 PG 31 WC Mathematical & Computational Biology; Statistics & Probability SC Mathematical & Computational Biology; Mathematics GA 832FX UT WOS:000295789600015 PM 21423564 ER PT J AU Moye, LA Lai, DJ Jing, KY Baraniuk, MS Kwak, M Penn, MS Wu, CO AF Moye, Lemuel A. Lai, Dejian Jing, Kaiyan Baraniuk, Mary Sarah Kwak, Minjung Penn, Marc S. Wu, Colon O. TI Combining Censored and Uncensored Data in a U-Statistic: Design and Sample Size Implications for Cell Therapy Research SO INTERNATIONAL JOURNAL OF BIOSTATISTICS LA English DT Article DE U-statistic; clinical trials; score function; stem cells ID ACUTE MYOCARDIAL-INFARCTION; MULTIPLE END-POINTS; VENTRICULAR ENLARGEMENT TRIAL; SEQUENTIAL CLINICAL-TRIALS; HEMATOPOIETIC STEM-CELLS; BONE-MARROW-CELLS; HEART-FAILURE; INTRACORONARY INJECTION; ISCHEMIC-MYOCARDIUM; MONONUCLEAR-CELLS AB The assumptions that anchor large clinical trials are rooted in smaller, Phase II studies. In addition to specifying the target population, intervention delivery, and patient follow-up duration, physician-scientists who design these Phase II studies must select the appropriate response variables (endpoints). However, endpoint measures can be problematic. If the endpoint assesses the change in a continuous measure over time, then the occurrence of an intervening significant clinical event (SCE), such as death, can preclude the follow-up measurement. Finally, the ideal continuous endpoint measurement may be contraindicated in a fraction of the study patients, a change that requires a less precise substitution in this subset of participants. A score function that is based on the U-statistic can address these issues of 1) intercurrent SCE's and 2) response variable ascertainments that use different measurements of different precision. The scoring statistic is easy to apply, clinically relevant, and provides flexibility for the investigators' prospective design decisions. Sample size and power formulations for this statistic are provided as functions of clinical event rates and effect size estimates that are easy for investigators to identify and discuss. Examples are provided from current cardiovascular cell therapy research. C1 [Moye, Lemuel A.] Univ Texas Hlth Sci Ctr Houston, Houston, TX USA. [Kwak, Minjung; Wu, Colon O.] NHLBI, Bethesda, MD 20892 USA. [Penn, Marc S.] Cleveland Clin Fdn, Cleveland, OH USA. RP Moye, LA (reprint author), Univ Texas Hlth Sci Ctr Houston, Houston, TX USA. FU NHLBI FX Three clinical trials in the NHLBI sponsored Cardiovascular Cell Therapy Research Network (CCTRN) are currently underway in which we will assess the utility of this approach. NR 41 TC 1 Z9 1 U1 1 U2 5 PU BERKELEY ELECTRONIC PRESS PI BERKELEY PA 2809 TELEGRAPH AVENUE, STE 202, BERKELEY, CA 94705 USA SN 1557-4679 J9 INT J BIOSTAT JI Int. J. Biostat. PY 2011 VL 7 IS 1 AR 29 DI 10.2202/1557-4679.1286 PG 30 WC Mathematical & Computational Biology; Statistics & Probability SC Mathematical & Computational Biology; Mathematics GA 832FX UT WOS:000295789600029 ER PT J AU Saito, K Matsumoto, S Devusahayam, N Subramanian, S Munasinghe, J Patel, V Gutkind, JS Mitchell, JB Cherukuri, MK AF Saito, Keito Matsumoto, Shingo Devusahayam, Nallathamby Subramanian, Sankaran Munasinghe, Jeeva Patel, Vyomesh Gutkind, J. Silvio Mitchell, James B. Cherukuri, Murali Krishna TI Rapamycin improves tumor oxygenation and vascular renormalization SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE LA English DT Meeting Abstract C1 [Saito, Keito; Matsumoto, Shingo; Devusahayam, Nallathamby; Subramanian, Sankaran; Mitchell, James B.; Cherukuri, Murali Krishna] NCI, Radiat Biol Branch, Ctr Canc Res, Bethesda, MD 20892 USA. [Munasinghe, Jeeva] Natl Inst Neurol Disorder & Stroke, Bethesda, MD 20892 USA. [Patel, Vyomesh; Gutkind, J. Silvio] Natl Inst Dent & Craniofacial Res, NIH, Bethesda, MD 20892 USA. RI Gutkind, J. Silvio/A-1053-2009 NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPANDIDOS PUBL LTD PI ATHENS PA POB 18179, ATHENS, 116 10, GREECE SN 1107-3756 J9 INT J MOL MED JI Int. J. Mol. Med. PY 2011 VL 28 SU 1 MA 375 BP S73 EP S73 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 827IR UT WOS:000295422700277 ER PT J AU Mattay, V AF Mattay, V TI Imaging Genetic Influences in Normal Cognitive Aging SO JOURNAL OF PSYCHOPHYSIOLOGY LA English DT Meeting Abstract C1 [Mattay, V] NIMH, Genes Cognit & Psychosis Program, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU HOGREFE & HUBER PUBLISHERS PI GOTTINGEN PA ROHNSWEG 25, D-37085 GOTTINGEN, GERMANY SN 0269-8803 J9 J PSYCHOPHYSIOL JI J. Psychophysiol. PY 2011 VL 25 SU 1 BP 22 EP 22 PG 1 WC Psychology, Biological; Neurosciences SC Psychology; Neurosciences & Neurology GA 832FA UT WOS:000295786600063 ER PT J AU Chrousos, GP Kino, T AF Chrousos, G. P. Kino, T. TI New Partners of the Glucocorticoid Receptor: Clock and Mutual, Multi-Level Interactions of the Circadian CLOCK System and the HPA Axis SO NEUROIMMUNOMODULATION LA English DT Meeting Abstract C1 Univ Athens, Dept Pediat 1, Athens, Greece. Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1021-7401 J9 NEUROIMMUNOMODULAT JI Neuroimmunomodulation PY 2011 VL 18 IS 6 BP 368 EP 368 PG 1 WC Endocrinology & Metabolism; Immunology; Neurosciences SC Endocrinology & Metabolism; Immunology; Neurosciences & Neurology GA 832FQ UT WOS:000295788700022 ER PT J AU Naude, PJW Eiden, LE den Boer, JA Luiten, PGM Eisel, ULM AF Naude, P. J. W. Eiden, L. E. den Boer, J. A. Luiten, P. G. M. Eisel, U. L. M. TI A Novel Neuroinflammatory Agent that Silences Tumour Necrosis Factor Alpha Receptor 2 Mediated Neuroprotection SO NEUROIMMUNOMODULATION LA English DT Meeting Abstract C1 [Naude, P. J. W.; Luiten, P. G. M.; Eisel, U. L. M.] Univ Groningen, NL-9700 AB Groningen, Netherlands. [Eiden, L. E.; den Boer, J. A.] NIMH, Mol Neurosci Sect, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1021-7401 J9 NEUROIMMUNOMODULAT JI Neuroimmunomodulation PY 2011 VL 18 IS 6 BP 394 EP 394 PG 1 WC Endocrinology & Metabolism; Immunology; Neurosciences SC Endocrinology & Metabolism; Immunology; Neurosciences & Neurology GA 832FQ UT WOS:000295788700095 ER PT J AU Silverman, M Marques, A Sternberg, EM AF Silverman, M. Marques, A. Sternberg, E. M. TI Neural Immune Mechanisms in Fatigue SO NEUROIMMUNOMODULATION LA English DT Meeting Abstract C1 [Silverman, M.; Sternberg, E. M.] NIMH, Sect Neuroendocrine Immunol & Behav, NIH, Bethesda, MD 20892 USA. [Marques, A.] Columbia Univ, New York, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1021-7401 J9 NEUROIMMUNOMODULAT JI Neuroimmunomodulation PY 2011 VL 18 IS 6 BP 405 EP 405 PG 1 WC Endocrinology & Metabolism; Immunology; Neurosciences SC Endocrinology & Metabolism; Immunology; Neurosciences & Neurology GA 832FQ UT WOS:000295788700124 ER PT J AU Watson, PH Ravid, R Eng, CB Litton, JE Vaught, J Matusan, A AF Watson, Peter H. Ravid, Rivka Eng, Chon Boon Litton, Jan-Eric Vaught, Jim Matusan, Anita TI What Are the Main Roadblocks to Transnational Biobank Collaboration, and How Can We Overcome Them? SO BIOPRESERVATION AND BIOBANKING LA English DT Editorial Material C1 [Watson, Peter H.] BC Canc Agcy, Victoria, BC V8R 6V5, Canada. [Ravid, Rivka] Royal Dutch Acad Sci, Brain Bank Consultants, Amsterdam, Netherlands. [Eng, Chon Boon] Natl Univ Hlth Syst, Yong Loo Lin Sch Med, NUHS Tissue Repository & Hosp Based Canc Registry, Singapore 119074, Singapore. [Litton, Jan-Eric] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. [Vaught, Jim] NCI, Off Biorepositories & Biospecimen Res, Bethesda, MD 20892 USA. [Matusan, Anita] Peter MacCallum Canc Ctr, Australasian Biospecimen Network Oncol, Melbourne, Vic 8006, Australia. RP Watson, PH (reprint author), BC Canc Agcy, 2410 Lee Ave, Victoria, BC V8R 6V5, Canada. EM pwatson@bccancer.bc.ca; rivkagravid@gmail.com; Chon_Boon_ENG@NUHS.edu.sg; Jan-Eric.Litton@ki.se; vaughtj@mail.nih.gov NR 0 TC 7 Z9 7 U1 0 U2 8 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1947-5535 J9 BIOPRESERV BIOBANK JI Biopreserv. Biobank. PY 2011 VL 9 IS 3 BP 213 EP 216 DI 10.1089/bio.2011.9340 PG 4 WC Cell Biology; Chemistry, Applied; Medical Laboratory Technology SC Cell Biology; Chemistry; Medical Laboratory Technology GA 827ST UT WOS:000295449200002 PM 24850325 ER PT J AU Yu, BB AF Yu, Binbing TI Estimating age-specific incidence of dementia using prevalent cohort data SO JOURNAL OF STATISTICAL COMPUTATION AND SIMULATION LA English DT Article DE dementia incidence; prevalent cohort; penalized likelihood ID SHORT-TERM PROJECTIONS; JAPANESE-AMERICAN MEN; ALZHEIMERS-DISEASE; TRUNCATED DATA; MORTALITY; STATIONARITY; INFECTION; MODELS AB In prospective cohort studies, individuals are usually recruited according to a certain cross-sectional sampling criterion. The prevalent cohort is defined as a group of individuals who are alive but possibly with disease at the beginning of the study. It is appealing to incorporate the prevalent cases to estimate the incidence rate of disease before the enrollment. The method of back calculation of incidence rate has been used to estimate the incubation time from human immunodeficiency virus (HIV) infection to AIDS. The time origin is defined as the time of HIV infection. In aging cohort studies, the primary time scale is age of disease onset, subjects have to survive certain years to be enrolled into the study, thus creating left truncation (delay entry). The current methods usually assume that either the disease incidence is rare or the excess mortality due to disease is small compared with the healthy subjects. So far the validity of the results based on these assumptions has not been examined. In this paper, a simple alternative method is proposed to estimate dementia incidence rate before enrollment using prevalent cohort data with left truncation. Furthermore, simulations are used to examine the performance of the estimation of disease incidence under different assumptions of disease incidence rates and excess mortality hazards due to disease. As application, the method is applied to the prevalent cases of dementia from the Honolulu-Asia Aging Study to estimate the dementia incidence rate and to assess the effect of hypertension, Apoe 4 and education on dementia onset. C1 NIA, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA. RP Yu, BB (reprint author), NIA, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA. EM yubi@mail.nih.gov FU National Institute on Aging under NIH [NIH12710587] FX The research was supported in part by the Intramural Research Program of the National Institute on Aging, under the NIH Grant No. NIH12710587. NR 23 TC 0 Z9 0 U1 0 U2 2 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 0094-9655 EI 1563-5163 J9 J STAT COMPUT SIM JI J. Stat. Comput. Simul. PY 2011 VL 81 IS 8 BP 973 EP 983 DI 10.1080/00949650903583496 PG 11 WC Computer Science, Interdisciplinary Applications; Statistics & Probability SC Computer Science; Mathematics GA 830UP UT WOS:000295683000004 PM 21860539 ER PT J AU Duque, LF Ungar, M Caicedo, B AF Duque, Luis F. Ungar, Michael Caicedo, Beatriz BE Denov, M Maclure, R Campbell, K TI Addressing Youth Violence and Aggression in Colombia: Examining a Community-Wide Prevention Initiative SO CHILDREN'S RIGHTS AND INTERNATIONAL DEVELOPMENT: LESSONS AND CHALLENGES FROM THE FIELD LA English DT Article; Book Chapter ID DEVELOPMENTAL TRAJECTORIES; PHYSICAL AGGRESSION; CONDUCT PROBLEMS; DELINQUENCY; BEHAVIOR; CHILDREN; BOYS; STABILITY; PATTERNS; FAMILIES C1 [Duque, Luis F.] Univ Antioquia, Sch Publ Hlth, PREVIVA Program Violence & Risky Conducts Prevent, Medellin, Colombia. [Duque, Luis F.] Natl Inst Hlth, Hlth Serv Direct, Bethesda, MD USA. [Duque, Luis F.] World Bank, Washington, DC USA. [Duque, Luis F.] WHO, New York, NY 10017 USA. [Ungar, Michael] Dalhousie Univ, Halifax, NS B3H 3J5, Canada. [Caicedo, Beatriz] Univ Bristol, Bristol BS8 1TH, Avon, England. RP Duque, LF (reprint author), Harvard Univ, Cambridge, MA 02138 USA. NR 47 TC 1 Z9 3 U1 0 U2 0 PU PALGRAVE PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE RG21 6XS, ENGLAND BN 978-0-23011-925-3 PY 2011 BP 129 EP 151 D2 10.1057/9780230119253 PG 23 WC Social Issues; Social Sciences, Interdisciplinary SC Social Issues; Social Sciences - Other Topics GA BWP76 UT WOS:000294449700007 ER PT J AU Tanofsky-Kraff, M Yanovski, SZ Yanovski, JA AF Tanofsky-Kraff, Marian Yanovski, Susan Z. Yanovski, Jack A. BE StriegelMoore, RH Wonderlich, SA Walsh, BT Mitchell, JE TI LOSS OF CONTROL OVER EATING IN CHILDREN AND ADOLESCENTS SO DEVELOPING AN EVIDENCE-BASED CLASSIFICATION OF EATING DISORDERS: SCIENTIFIC FINDINGS FOR DSM-5 LA English DT Article; Book Chapter ID AGE-OF-ONSET; OVERWEIGHT CHILDREN; CLINICAL-SIGNIFICANCE; DISORDER EXAMINATION; OBESE INDIVIDUALS; BULIMIC BEHAVIORS; SEEKING TREATMENT; COMMUNITY SAMPLE; CONTROLLED-TRIAL; ADULT OBESITY C1 [Tanofsky-Kraff, Marian] Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Bethesda, MD 20814 USA. [Yanovski, Jack A.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Unit Growth & Obes, Program Dev Endocrinol & Genet, NIH,Dept Hlth & Human Serv, Bethesda, MD USA. [Yanovski, Susan Z.] NIDDKD, Off Obes Res, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA. [Yanovski, Susan Z.] NIDDKD, Obes & Eating Disorders Program, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA. RP Tanofsky-Kraff, M (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Bethesda, MD 20814 USA. NR 63 TC 14 Z9 14 U1 1 U2 1 PU AMER PSYCHIATRIC PRESS, INC PI WASHINGTON PA 1400 K ST NW, WASHINGTON, DC 20005 USA BN 978-0-89042-666-1 PY 2011 BP 221 EP 236 PG 16 WC Psychology, Clinical; Psychiatry; Psychology SC Psychology; Psychiatry GA BWM09 UT WOS:000294220100017 ER PT S AU Bagci, U Udupa, JK Chen, XJ AF Bagci, Ulas Udupa, Jayaram K. Chen, Xinjian BE Wong, KH Holmes, DR TI Intensity Non-standardness Affects Computer Recognition of Anatomical Structures SO MEDICAL IMAGING 2011: VISUALIZATION, IMAGE-GUIDED PROCEDURES, AND MODELING SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Medical Imaging 2011 - Visualization, Image-Guided Procedures, and Modeling CY FEB 13-15, 2011 CL Lake Buena Vista, FL SP SPIE, Dynasil Corp/RMD Res, AAPM - Amer Assoc Physicists Med, DQE Instruments, Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc DE Intensity Standardization; Object Recognition; Model Based Segmentation; 3D Models ID INHOMOGENEITY CORRECTION; SCALE; STANDARDIZATION AB Since MR image intensities do not possess a tissue specific numeric meaning, even in images acquired for the same subject, on the same scanner, for the same body region, by using the same pulse sequence, it is important to transform the image scale into a standard intensity scale so that, for the same body region, intensities are similar. The lack of a standard image intensity scale in MRI leads to many difficulties in tissue characterizability, image display, and analysis, including image segmentation and registration. The influence of standardization on these tasks has been documented well; however, how intensity non-standardness may affect the automatic recognition of anatomical structures for image segmentation has not been studied. Motivated from the study that we previously presented in SPIE Medical Imaging Conference 2010,(1, 2) in this study, we analyze the effects of intensity standardization on anatomical object recognition. A set of 31 scenarios of multiple objects from the ankle complex included in the model, plus seven different realistic levels of non-standardness introduced are considered for evaluation. The experimental results imply that, intensity variation among scenes in an ensemble - a particular characteristic of the behavior of non-standardness - degrades object recognition performance. C1 [Bagci, Ulas; Chen, Xinjian] NIH, Ctr Clin, Bethesda, MD 20814 USA. RP Bagci, U (reprint author), NIH, Ctr Clin, Off 1C370, Bethesda, MD 20814 USA. EM ulasbagci@ieee.org OI Bagci, Ulas/0000-0001-7379-6829 NR 11 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8506-9 J9 PROC SPIE PY 2011 VL 7964 AR 79642M DI 10.1117/12.877779 PG 9 WC Engineering, Electrical & Electronic; Optics; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Optics; Radiology, Nuclear Medicine & Medical Imaging GA BWM23 UT WOS:000294224900088 ER PT S AU Kapoor, A Li, M Wood, B AF Kapoor, Ankur Li, Ming Wood, Bradford BE Wong, KH Holmes, DR TI Mixed Variable Optimization for Radio Frequency Ablation Planning SO MEDICAL IMAGING 2011: VISUALIZATION, IMAGE-GUIDED PROCEDURES, AND MODELING SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Medical Imaging 2011 - Visualization, Image-Guided Procedures, and Modeling CY FEB 13-15, 2011 CL Lake Buena Vista, FL SP SPIE, Dynasil Corp/RMD Res, AAPM - Amer Assoc Physicists Med, DQE Instruments, Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc DE Optimization; RFA Planning; Mixed Variable ID OF-THE-ART; FEASIBILITY; ASSISTANCE; ROBOT; MR AB We present a method towards optimization of multiple ablation probe placement to provide efficient coverage of a tumor for thermal therapy while respecting clinical needs such as limiting the sites of probe insertions at the pleura/liver surface, choosing secure probe trajectories and locations, avoiding ablation of critical structures, reducing ablation of healthy tissue and overlap of ablation zones. The ablation optimizer treats each ablation location independently, and the number of ablation probe placements itself is treated as a variable to be optimized. This allows us to potentially feedback the ablation after deployment and re-optimize the next steps during the plan. The optimization method uses a new class of derivate-free algorithms for solving a non-linear mixed variable problem with hard and soft constraints derived from clinical images. Our methods use discretization of the ablation volume, which can accommodate irregular shape of the ablation zone. The non-gradient based strategy produce new candidates to yield a feasible solution within a few iterations. In our simulation experiments this strategy typically reduced the ablation zone overlap and ablated healthy tissue ablated by 46% and 29%, respectively in a single iteration, resulting in a feasible solution to be found within 35 iterations. Our method for optimization provides efficient implementation for planning the coverage of a tumor while respecting clinical constraints. The ablation planning can be combined with navigation assistance to enable accurate translation and feedback of the plan. C1 [Kapoor, Ankur; Wood, Bradford] NIH, Ctr Clin, Bethesda, MD 20892 USA. RP Kapoor, A (reprint author), NIH, Ctr Clin, Bethesda, MD 20892 USA. NR 16 TC 0 Z9 0 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8506-9 J9 PROC SPIE PY 2011 VL 7964 AR 796420 DI 10.1117/12.876499 PG 7 WC Engineering, Electrical & Electronic; Optics; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Optics; Radiology, Nuclear Medicine & Medical Imaging GA BWM23 UT WOS:000294224900067 ER PT S AU Mann, D Caban, JJ Stolka, PJ Boctor, EM Yoo, TS AF Mann, David Caban, Jesus J. Stolka, Phillip J. Boctor, Emad M. Yoo, Terry S. BE Wong, KH Holmes, DR TI Multi-Dimensional Transfer Functions for Effective Visualization of Streaming Ultrasound and Elasticity Images SO MEDICAL IMAGING 2011: VISUALIZATION, IMAGE-GUIDED PROCEDURES, AND MODELING SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Medical Imaging 2011 - Visualization, Image-Guided Procedures, and Modeling CY FEB 13-15, 2011 CL Lake Buena Vista, FL SP SPIE, Dynasil Corp/RMD Res, AAPM - Amer Assoc Physicists Med, DQE Instruments, Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc DE Visualization; Ultrasound; Elasticity Imaging AB The low-cost and minimum health risks associated with ultrasound (US) have made ultrasonic imaging a widely accepted method to perform diagnostic and image-guided procedures. Despite the existence of 3D ultrasound probes, most analysis and diagnostic procedures are done by studying the B-mode images. Currently, multiple ultrasound probes include 6-DOF sensors that can provide positioning information. Such tracking information can be used to reconstruct a 3D volume from a set of 2D US images. Recent advances in ultrasound imaging have also shown that, directly from the streaming radio frequency (RF) data, it is possible to obtain additional information of the anatomical region under consideration including the elasticity properties. This paper presents a generic framework that takes advantage of current graphics hardware to create a low-latency system to visualize streaming US data while combining multiple tissue attributes into a single illustration. In particular, we introduce a framework that enables real-time reconstruction and interactive visualization of streaming data while enhancing the illustration with elasticity information. The visualization module uses two-dimensional transfer functions (2D TFs) to more effectively fuse and map B-mode and strain values into specific opacity and color values. On commodity hardware, our framework can simultaneously reconstruct, render, and provide user interaction at over 15 fps. Results with phantom and real-world medical datasets show the advantages and effectiveness of our technique with ultrasound data. In particular, our results show how two-dimensional transfer functions can be used to more effectively identify, analyze and visualize lesions in ultrasound images. C1 [Mann, David; Caban, Jesus J.; Yoo, Terry S.] NIH, Natl Lib Med, Bethesda, MD 20892 USA. RP Mann, D (reprint author), NIH, Natl Lib Med, Bethesda, MD 20892 USA. RI Boctor, Emad/I-6597-2012 NR 9 TC 1 Z9 1 U1 1 U2 4 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8506-9 J9 PROC SPIE PY 2011 VL 7964 AR 796439 DI 10.1117/12.878935 PG 10 WC Engineering, Electrical & Electronic; Optics; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Optics; Radiology, Nuclear Medicine & Medical Imaging GA BWM23 UT WOS:000294224900110 ER PT S AU Blum, A AF Blum, Alan BE Connolly, T TI LIFE, DEATH AND THE IN-BETWEEN: THE DUCK-RABBIT/THE FACE OF THE CLOWN SO SPECTACULAR DEATH: INTERDISCIPLINARY PERSPECTIVES ON MORTALITY AND (UN)REPRESENTABILITY SE Culture Disease and Well-Being LA English DT Article; Book Chapter C1 [Blum, Alan] Harvard Univ, Sch Med, NIMH, Cambridge, MA 02138 USA. [Blum, Alan] Univ Cambridge, Univ London Kings Coll, Amer Council Learned Soc, Cambridge CB2 1TN, England. [Blum, Alan] Univ Chicago, Jury Project, Chicago, IL 60637 USA. [Blum, Alan] Roosevelt Hosp, Res Program Sociol Hlth & Illness, New York, NY USA. [Blum, Alan] Columbia Univ, New York, NY 10027 USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU INTELLECT LTD PI OXFORD PA KENNETT HOUSE, SUITE 2 108/110 LONDON RD, OXFORD OX3 9AW, ENGLAND SN 2042-1788 BN 978-1-84150-322-6 J9 CULT DIS WELL BEING PY 2011 BP 21 EP 41 PG 21 WC History & Philosophy Of Science; Philosophy SC History & Philosophy of Science; Philosophy GA BVR73 UT WOS:000292594500002 ER PT J AU Choibamroong, T AF Choibamroong, Therdchai (Ted) BE Laws, E Richins, H Agrusa, J Scott, N TI A Stakeholder Approach for Sustainable Community-based Rural Tourism Development in Thailand SO TOURIST DESTINATION GOVERNANCE: PRACTICE, THEORY AND ISSUES LA English DT Article; Book Chapter C1 NIDA, NIDA Ctr Integrated Tourism Management Studies NI, Bangkok 10240, Thailand. RP Choibamroong, T (reprint author), NIDA, NIDA Ctr Integrated Tourism Management Studies NI, 118 Moo3,Sereethai Rd, Bangkok 10240, Thailand. EM tedchoibamroong@hotmail.com NR 25 TC 0 Z9 0 U1 0 U2 0 PU CABI PUBLISHING-C A B INT PI WALLINGFORD PA CABI PUBLISHING, WALLINGFORD 0X10 8DE, OXON, ENGLAND BN 978-1-84593-794-2 PY 2011 BP 173 EP 186 D2 10.1079/9781845937942.0000 PG 14 WC Hospitality, Leisure, Sport & Tourism SC Social Sciences - Other Topics GA BWN24 UT WOS:000294281000015 ER PT B AU Vogler, JA Jackson, W Nesti, LJ AF Vogler, Jared A. Jackson, Wesley Nesti, Leon J. BE Owens, BD Belmont, PJ TI TISSUE ENGINEERING AND REGENERATION SO COMBAT ORTHOPEDIC SURGERY: LESSONS LEARNED IN IRAQ AND AFGHANISTAN LA English DT Article; Book Chapter ID PLATELET-RICH PLASMA; GROWTH-FACTOR-BETA; MESENCHYMAL PROGENITOR CELLS; ORTHOPEDIC-SURGERY; STEM-CELLS; IN-VITRO; NANOFIBROUS SCAFFOLD; GENE FAMILY; BONE; LIGAMENT C1 [Vogler, Jared A.; Jackson, Wesley] Walter Reed Natl Mil Med Ctr, Washington, DC USA. [Vogler, Jared A.; Jackson, Wesley] NIAMSD, Clin & Expt Orthopaed Grp, NIH, Bethesda, MD 20892 USA. [Jackson, Wesley] McDonald Army Hlth Ctr, Orthopaed Surg Serv, Ft Eustis, VA USA. RP Vogler, JA (reprint author), Walter Reed Natl Mil Med Ctr, Washington, DC USA. NR 58 TC 0 Z9 0 U1 0 U2 1 PU SLACK INC PI THOROFARE PA 6900 GROVE ROAD, THOROFARE, NJ 08086-9447 USA BN 978-1-55642-965-1 PY 2011 BP 101 EP 108 PG 8 WC Orthopedics; Surgery SC Orthopedics; Surgery GA BTZ12 UT WOS:000288484200012 ER PT B AU White, SS Fenton, SE Yang, CF Haslam, SZ AF White, Sally S. Fenton, Suzanne E. Yang, Chengfeng Haslam, Sandra Z. BE Russo, J TI Mammary Gland as a Sensitive Tissue to Developmental Exposures of Perfluorooctanoic Acid (PFOA) in the Mouse SO ENVIRONMENT AND BREAST CANCER LA English DT Article; Book Chapter DE PFOA; Exposure; Health effects; Mice; Mammary gland; In utero; Lactation; Peripuberty; Endocrine disruptor ID RESTRICTED GESTATIONAL EXPOSURES; ACTIVATED RECEPTOR-ALPHA; PERFLUORINATED CHEMICALS; AMMONIUM PERFLUOROOCTANOATE; PERFLUOROALKYL COMPOUNDS; SERUM CONCENTRATIONS; COMMUNITY EXPOSURE; CARBOXYLIC-ACIDS; SULFONATE PFOS; LIVER-ENZYMES AB The persistence in the environment, combined with the ubiquity of perfluorinated products in the marketplace, has caused what is now recognized as the widespread contamination of human and wildlife tissues with perfluorooctanoic acid (PFOA). The global presence of PFOA has raised concern about adverse health effects that may result from unavoidable human exposures. In this review, we cover the sources of PFOA, its prevalence, and current knowledge about human PFOA exposures and associated health consequences. Examined in detail are PFOA-induced effects on mammary gland in animals. Studies of other environmental agents indicate that late fetal and early postnatal mammary gland development is particularly sensitive to environmental insult. Early life exposures that alter mammary gland development are thought to have a potential impact on the development of mammary cancers later in life in animal models. This is also thought to be the case in humans. Recent research in the mouse examining the effects of in utero, lactational and peripubertal exposures, impact of genetic background, and putative mechanisms of action has made substantial discoveries regarding the effects of PFOA exposure on the mammary gland with high relevancy to human health. C1 [Yang, Chengfeng; Haslam, Sandra Z.] Michigan State Univ, Dept Biomed & Integrat Physiol, E Lansing, MI 48824 USA. [Yang, Chengfeng; Haslam, Sandra Z.] Michigan State Univ, Breast Canc & Environm Res Ctr, E Lansing, MI 48824 USA. [White, Sally S.; Fenton, Suzanne E.] NIEHS, Natl Toxicol Program, Res Triangle Pk, NC 27709 USA. [Yang, Chengfeng] Michigan State Univ, Ctr Integrat Toxicol, E Lansing, MI 48824 USA. RP Haslam, SZ (reprint author), Michigan State Univ, Dept Biomed & Integrat Physiol, E Lansing, MI 48824 USA. EM suzanne.fenton@nih.gov; shaslam@msu.edu NR 77 TC 0 Z9 0 U1 0 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4419-9895-8 PY 2011 BP 147 EP 166 DI 10.1007/978-1-4419-9896-5_8 D2 10.1007/978-1-4419-9896-5 PG 20 WC Oncology; Environmental Sciences SC Oncology; Environmental Sciences & Ecology GA BWO10 UT WOS:000294369200008 ER PT B AU Rayner, JL Fenton, SE AF Rayner, Jennifer L. Fenton, Suzanne E. BE Russo, J TI Atrazine: An Environmental Endocrine Disruptor That Alters Mammary Gland Development and Tumor Susceptibility SO ENVIRONMENT AND BREAST CANCER LA English DT Article; Book Chapter DE Atrazine; HPG axis; Endocrine disruptor; Herbicide; Mammary gland; Lactation; Tumor development ID SPRAGUE-DAWLEY RATS; LONG-EVANS RATS; PRENATAL EXPOSURE; OVARIAN-FUNCTION; CANCER INCIDENCE; BREAST-CANCER; FEMALE RATS; WISTAR RAT; METABOLITES; GROWTH AB Atrazine, a widely used chlorotriazine herbicide, has been regulated and reviewed because of its ability to alter endocrine signaling and cause mammary tumors in female Sprague-Dawley rats. The ability of atrazine to cause breast cancer in humans has been studied and the results are equivocal. Rodent studies showed that atrazine alters the developing mammary gland, makes it susceptible to tumorigenesis or hyperplasia, alters lactational ability, and decreases weight gain in second-generation litters. This chapter reviews the proposed mode of action for mammary tumorigenesis in rodents, results of human studies, and potential modes of action for atrazine effects on the developing mammary gland. C1 [Fenton, Suzanne E.] NIEHS, Natl Toxicol Program, Res Triangle Pk, NC 27709 USA. [Rayner, Jennifer L.] Oak Ridge Natl Lab, Toxicol & Hazard Assessment Grp, Oak Ridge, TN USA. RP Fenton, SE (reprint author), NIEHS, Natl Toxicol Program, POB 12233, Res Triangle Pk, NC 27709 USA. EM suzanne.fenton@nih.gov NR 62 TC 5 Z9 5 U1 1 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4419-9895-8 PY 2011 BP 167 EP 183 DI 10.1007/978-1-4419-9896-5_9 D2 10.1007/978-1-4419-9896-5 PG 17 WC Oncology; Environmental Sciences SC Oncology; Environmental Sciences & Ecology GA BWO10 UT WOS:000294369200009 ER PT J AU Johnson, RA Beck, AM McCune, S Griffin, JA Esposito, L AF Johnson, Rebecca A. Beck, Alan M. McCune, Sandra Griffin, James A. Esposito, Layla BA Johnson, RA Beck, AM McCune, S BF Johnson, RA Beck, AM McCune, S TI Future directions in dog walking SO HEALTH BENEFITS OF DOG WALKING FOR PEOPLE AND PETS: EVIDENCE AND CASE STUDIES SE New Directions in the Human-Animal Bond LA English DT Article; Book Chapter ID PHYSICAL-ACTIVITY; CHILDREN; OBESITY; PREVENTION; THERAPY; GROWTH; HEALTH; BITES C1 [Johnson, Rebecca A.] Univ Missouri, Coll Vet Med, Sinclair Sch Nursing, Columbia, MO 65211 USA. [Johnson, Rebecca A.] Univ Missouri, Coll Vet Med, Res Ctr Human Anim Interact, Columbia, MO USA. [Griffin, James A.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Child Dev & Behav Branch, Ctr Res Mothers & Children, NIH, Rockville, MD USA. [Beck, Alan M.] Purdue Univ, Sch Vet Med, W Lafayette, IN 47907 USA. RP Johnson, RA (reprint author), Univ Missouri, Coll Vet Med, Sinclair Sch Nursing, Columbia, MO 65211 USA. NR 35 TC 0 Z9 0 U1 1 U2 4 PU PURDUE UNIV PRESS PI W LAFAYETTE PA SOUTH CAMPUS COURTS D, W LAFAYETTE, IN 47907 USA BN 978-1-55753-582-5 J9 NEW DIR HUM-ANIM BON PY 2011 BP 181 EP 191 PG 11 WC Public, Environmental & Occupational Health; Veterinary Sciences SC Public, Environmental & Occupational Health; Veterinary Sciences GA BWJ18 UT WOS:000294004000012 ER PT B AU Doria-Rose, VP Szabo, E AF Doria-Rose, V. Paul Szabo, Eva BA Kernstine, KH Reckamp, KL BF Kernstine, KH Reckamp, KL TI Screening and Prevention of Lung Cancer SO LUNG CANCER: A MULTIDISCIPLINARY APPROACH TO DIAGNOSIS AND MANAGEMENT SE Current Multidisciplinary Oncology LA English DT Article; Book Chapter ID LOW-DOSE CT; SPIRAL COMPUTED-TOMOGRAPHY; COST-EFFECTIVENESS ANALYSIS; GUIDELINES 2ND EDITION; RANDOMIZED CONTROLLED TRIAL; VOLATILE ORGANIC-COMPOUNDS; NEEDLE ASPIRATION BIOPSY; CARCINOMA IN-SITU; HIGH-RISK COHORT; CHEST-X-RAY C1 [Doria-Rose, V. Paul] NCI, Div Canc Control & Populat Sci, NIH, Bethesda, MD 20892 USA. [Szabo, Eva] NCI, Canc Res Grp, Canc Prevent Div, NIH, Bethesda, MD 20892 USA. RP Doria-Rose, VP (reprint author), NCI, Div Canc Control & Populat Sci, NIH, Bethesda, MD 20892 USA. NR 160 TC 1 Z9 1 U1 0 U2 4 PU DEMOS MEDICAL PUBLICATIONS PI NEW YORK PA 11 WEST 42ND STREET, 15TH FLOOR, NEW YORK, NY 10036 USA BN 978-1-936287-06-2 J9 CURR MULTIDISC ONCOL PY 2011 BP 53 EP 72 PG 20 WC Oncology SC Oncology GA BRY52 UT WOS:000283895900005 ER PT B AU Mukhopadhyay, P Gurusamy, N Das, DK AF Mukhopadhyay, Partha Gurusamy, Narasimman Das, Dipak K. BE Dhalla, NS Nagano, M Ostadal, B TI Stem Cell, MicroRNA and Redox Cycling SO MOLECULAR DEFECTS IN CARDIOVASCULAR DISEASE LA English DT Article; Book Chapter DE Cardiac stem cells; Resveratrol; Redox; Nrf2; Ref-1; NFkB; Heart; Ischemia ID BREAST-CANCER CELLS; HEMATOPOIETIC PROGENITOR CELLS; OXIDATIVE STRESS; ADHESION MOLECULES; BONE-MARROW; PERIPHERAL-BLOOD; MYOCARDIAL-INFARCTION; ANIMAL MICRORNAS; EMBRYOID BODIES; ISCHEMIC-HEART AB Mobilization and homing of the hematopoietic stern cells appear to be regulated by mechanism involving redox cycling. Stem cells are localized inside bone marrow in a strictly hypoxic environment and must move to the injury site that is subjected to oxidative environment. Cytokines and adhesion molecules control stem cell mobilization through a redox-regulated process. The major hitch in stem cell therapy includes the life of the stem cells after the stem cell therapy; most cells do not survive beyond 24-72 h. Sudden exposure of the stem cells from the hypoxic melieu into the oxidative environment likely causes severe injury to the cells. FoxO-SirT network appears to be intimately involved in redox-regulated stem cell homeostasis, while their differentiation process is regulated by redox factor protein-1, Ref-1. Lack of oxygen [hypoxia], specifically controlled hypoxia can stimulate the growth of the stem cells in their niche, and HIF-1 alpha plays a significant role in their maintenance and homing mechanism. Recently, resveratrol, a polyphenolic phytoalexin, prolonged the survival of the stem cells as evidenced by active proliferation and differentiation of the cells even after 4 months of cell therapy. The enhancement of stem cell survival was shown to be due to the ability of resveratrol to maintain a reduced tissue environment by over-expressing Nrf2 and Ref-1 in rat heart up to 6 months resulting in an enhancement of the regeneration of the adult cardiac stern cells as evidenced by increased cell survival and differentiation leading to improved cardiac function. Expression of stromal cell-derived factor (SDF) and myosin conclusively demonstrated homing of stem cells in the infracted myocardium, its regeneration leading to improvement of cardiac function. C1 [Gurusamy, Narasimman; Das, Dipak K.] Univ Connecticut, Sch Med, Cardiovasc Res Ctr, Farmington, CT 06030 USA. [Mukhopadhyay, Partha] NIAAA, Lab Physiol Studies, NIH, Bethesda, MD USA. RP Das, DK (reprint author), Univ Connecticut, Sch Med, Cardiovasc Res Ctr, Farmington, CT 06030 USA. EM ddas@neuron.uchc.edu NR 107 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4419-7129-6 PY 2011 BP 69 EP 81 DI 10.1007/978-1-4419-7130-2_6 D2 10.1007/978-1-4419-7130-2 PG 13 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA BWR48 UT WOS:000294660600006 ER PT B AU Keusch, GT AF Keusch, Gerald T. BE Parker, R Sommer, M TI Models of Cooperation, Capacity Building, and the Future of Global Health SO ROUTLEDGE HANDBOOK OF GLOBAL PUBLIC HEALTH LA English DT Article; Book Chapter C1 [Keusch, Gerald T.] Boston Univ, Sch Publ Hlth, Ctr Global Hlth & Dev, Boston, MA 02215 USA. [Keusch, Gerald T.] Natl Inst Hlth, Fogarty Int Ctr, Bethesda, MD 20892 USA. RP Keusch, GT (reprint author), Boston Univ, Sch Publ Hlth, Ctr Global Hlth & Dev, Boston, MA 02215 USA. NR 12 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE PI LONDON PA 11 NEW FETTER LANE, LONDON EC4P 4EE, ENGLAND BN 978-0-203-83272-1; 978-0-415-77848-0 PY 2011 BP 497 EP 505 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA BVZ61 UT WOS:000293213300049 ER PT B AU Lee, TL Cheung, AHH Rennert, OM Chan, WY AF Lee, Tin-Lap Cheung, Albert Hoi-Hung Rennert, Owen M. Chan, Wai-Yee BE Zini, A Agarwal, A TI RNA Expression in Male Germ Cells During Spermatogenesis (Male Germ Cell Transcriptome) SO SPERM CHROMATIN: BIOLOGICAL AND CLINICAL APPLICATIONS IN MALE INFERTILITY AND ASSISTED REPRODUCTION LA English DT Article; Book Chapter DE RNA expression in germ cells; Spermatogenesis; Germ cell transcriptome; Male germ cell development; Serial analysis of gene expression ID LONG NONCODING RNAS; SEX-CHROMOSOME INACTIVATION; COMPREHENSIVE SAGE DATABASE; MICROARRAY EXPERIMENT MIAME; TISSUE-SPECIFIC EXPRESSION; MOUSE X-CHROMOSOME; GENE-EXPRESSION; ALTERNATIVE PROMOTERS; MINIMUM INFORMATION; EMBRYONIC GONAD AB Spermatogenesis is a key process in mammalian reproduction. This highly ordered process requires precise and well-controlled programs governed by dynamic patterns of gene expression. Some genes are exclusive to spermatogenic cells, while others are closely related to genes expressed in somatic: cells. Although key genes in male germ cell development have been identified, the biological mechanisms and transcripts that govern the programs of spermatogonial stem cell renewal, germ cell differentiation during spermatogenesis, or fertilization remain largely unknown. This is partly due to the lack of information on the identity of genes involved. However, with the advent of various high-throughput genomic assays, it is now possible to obtain the whole-genome RNA expression. This chapter provides a brief account of current knowledge of the male germ cell transcriptome as revealed by studies using expression profiling platforms such as microarray and Serial Analysis of Gene Expression (SAGE). Major findings with regard to transcriptional regulation, transcript diversity, and chromatin-related regulation during male germ cell development are reviewed. C1 [Lee, Tin-Lap; Cheung, Albert Hoi-Hung; Chan, Wai-Yee] Chinese Univ Hong Kong, Sch Biomed Sci, Reprod Dev & Endocrinol Program, Shatin, Hong Kong, Peoples R China. [Lee, Tin-Lap; Rennert, Owen M.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Lab Clin & Dev Genom, NIH, Bethesda, MD USA. RP Lee, TL (reprint author), Chinese Univ Hong Kong, Sch Biomed Sci, Reprod Dev & Endocrinol Program, Shatin, Hong Kong, Peoples R China. EM leetl@cuhk.edu.hk RI Lee, Tin-Lap/A-7853-2009 OI Lee, Tin-Lap/0000-0002-6654-0988 NR 99 TC 1 Z9 1 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4419-1781-2 PY 2011 BP 107 EP 121 DI 10.1007/978-1-4419-6857-9_8 D2 10.1007/978-1-4419-6857-9 PG 15 WC Andrology; Reproductive Biology SC Endocrinology & Metabolism; Reproductive Biology GA BWP55 UT WOS:000294445300008 ER PT B AU Soekadar, SR Birbaumer, N Cohen, LG AF Soekadar, Surjo R. Birbaumer, Niels Cohen, Leonardo G. BE Kansaku, K Cohen, LG TI Brain-Computer Interfaces in the Rehabilitation of Stroke and Neurotrauma SO SYSTEMS NEUROSCIENCE AND REHABILITATION LA English DT Article; Book Chapter ID TRANSCRANIAL MAGNETIC STIMULATION; PRIMARY MOTOR CORTEX; EVENT-RELATED DESYNCHRONIZATION; NONINVASIVE CORTICAL STIMULATION; RANDOMIZED CONTROLLED-TRIAL; MACHINE INTERFACES; MOVEMENT DIRECTION; SUBCORTICAL STROKE; SKILL ACQUISITION; PREMOTOR AREAS AB Paralysis after stroke or neurotrauma is among the leading causes of long term disability in adults. The development of brain-computer interface (BCI) systems that allow online classification of electric or metabolic brain activity and their translation into control signals of external devices or computers have led to two major approaches in tackling the problem of paralysis. While assistive Bel systems strive for continuous high-dimensional control of robotic devices or functional electric stimulation (FES) of paralyzed muscles to substitute for lost motor functions in a 'daily life environment (e.g. Velliste et al. 2008 [1]; Hochberg et al. 2006 [2]; Pfurtscheller et al. 2000 [3]), restorative BCI systems aim at normalization of neurophysiologic activity that might facilitate motor recovery (e.g. Birbaumer et al. 2007, 2009 [4, 5]; Daly et al. 2008 [6]). In order to make assistive BCI systems work in daily life, high BCI communication speed is necessary, an issue that by now can only be achieved by invasive recordings of brain activity (e.g. via multi-unit arrays, MUA, or electrocorticogram, ECoG). Restorative BCI systems, in contrast, were developed as training tools based on non-invasive methods such as electro- or magnetoencephalography (EEG/MEG). More recently developed approaches use real-time functional magnetic resonance imaging (rtfMRI) or near-infrared spectroscopy (NIRS). Here, we provide an overview of the current state in the development and application of assistive and restorative BCI and introduce novel approaches to improve BCI control with brain stimulation such as transcranial direct current stimulation (tDCS). The outlook of using BCI in rehabilitation of stroke and neurotrauma is discussed. C1 [Soekadar, Surjo R.; Cohen, Leonardo G.] NINDS, Human Cort Physiol & Stroke Neurorehabil Sect, NIH, Bethesda, MD 20892 USA. [Soekadar, Surjo R.; Birbaumer, Niels] Univ Tubingen, Inst Med Psychol & Behav Neurobiol, Tubingen, Germany. [Birbaumer, Niels] Osped san Camillo, IRCCS, Venice, Italy. RP Cohen, LG (reprint author), NINDS, Human Cort Physiol & Stroke Neurorehabil Sect, NIH, 10 Ctr Dr, Bethesda, MD 20892 USA. EM cohenl@ninds.nih.gov; cohenl@ninds.nih.gov OI Soekadar, Surjo R./0000-0003-1280-5538 NR 117 TC 13 Z9 13 U1 1 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-4-431-53998-8 PY 2011 BP 3 EP 18 DI 10.1007/978-4-431-54008-3_1 D2 10.1007/978-4-431-54008-3 PG 16 WC Neurosciences; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA BWO16 UT WOS:000294371300001 ER PT S AU Zhou, XB Wang, Y Wang, HH Pham, TD Li, K AF Zhou, Xiaobo Wang, Yuan Wang, Honghui Pham, Tuan D. Li, King BE Pham, TD Zhou, X Tanaka, H OyamaHiga, M Jiang, X Sun, C Kowalski, J Jia, X TI Biomarker Motif Discovery by Integrating Mass Spectrometry and PPI Network SO 2011 INTERNATIONAL SYMPOSIUM ON COMPUTATIONAL MODELS FOR LIFE SCIENCES (CMLS-11) SE AIP Conference Proceedings LA English DT Proceedings Paper CT International Symposium on Computational Models for Life Sciences (CMLS-11) CY OCT 11-13, 2011 CL Toyama, JAPAN SP IEEE Engn Med & Biol Soc (EMBS), IEEE Syst, Man & Cybernet Soc (SMCS), Chaos Technol Res Lab, Japan, Univ New S Wales, Canberra Campus, Topcon, Japan DE Biomarker Motif; MS; PPI ID CANCER; PATHWAYS; BIOLOGY; TOOL AB Traditional mass spectrometry biomarker discovery studies which focus on single biomarkers or a panel of biomarkers have shown their limitations with low reproducibility. In this paper, we propose a novel biomarker motif discovery approach by integrating both mass spectrometry data and protein interaction network information together to identify biomarkers. A novel Bayesian score method is developed to score the protein subnetwork both from the expression of protein and from the protein interaction network structure. Compared with the previous biomarker discovery method, our biomarker motif identification method not only models the expression of each protein, but also the relationship of proteins affected by the protein-protein interaction network. The experiment results show that our proposed biomarker discovery method has a higher sensitivity and lower false discovery rates than previously used methods. When applying our biomarker motifs discovery approach to the real stroke mass spectrometry data, we can identify several biomarker motifs for ischemic stroke which can achieve a higher classification performance with high biological significance. C1 [Zhou, Xiaobo; Wang, Yuan; Li, King] Methodist Hosp, Dept Radiol, Res Inst, Weill Cornell Med Coll, Houston, TX 77030 USA. [Wang, Honghui] NIH, Dept Crit Care Med, Ctr Clin, Bethesda, MD 20892 USA. [Pham, Tuan D.] Univ New South Wales, Sch Informat Technol & Engn, Bioinformat Res Grp, Canberra, ACT 2600, Australia. RP Zhou, XB (reprint author), Methodist Hosp, Dept Radiol, Res Inst, Weill Cornell Med Coll, Houston, TX 77030 USA. FU NIH [1R01LM010185-01]; Simmons Family Foundation FX This work is partially funded by NIH 1R01LM010185-01 (Zhou & Chang) and Simmons Family Foundation (Zhou). NR 16 TC 1 Z9 1 U1 0 U2 0 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-0931-6 J9 AIP CONF PROC PY 2011 VL 1371 BP 225 EP 233 DI 10.1063/1.3596646 PG 9 WC Physics, Applied SC Physics GA BWT24 UT WOS:000294779500025 ER PT B AU Aly, H Berra, L Kolobow, T AF Aly, Hany Berra, Lorenzo Kolobow, Theodor BE Esquinas, AM TI Gravitational Force and Respiratory Colonization in Mechanical Ventilation SO APPLIED TECHNOLOGIES IN PULMONARY MEDICINE LA English DT Article; Book Chapter ID BACTERIAL-COLONIZATION; PNEUMONIA; TUBE; ASPIRATION; POSITION; ORIENTATION; TRIAL; CARE C1 [Aly, Hany] George Washington Univ, Div Newborn Serv, Washington, DC 20037 USA. [Aly, Hany] Childrens Natl Med Ctr, Washington, DC 20010 USA. [Berra, Lorenzo] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Kolobow, Theodor] NHLBI, Pulm & Crit Care Med Branch, NIH, Bethesda, MD 20892 USA. RP Aly, H (reprint author), George Washington Univ, Div Newborn Serv, 900 23rd St NW,Suite G-2092,Room G-132, Washington, DC 20037 USA. EM haly@mfa.gwu.edu NR 11 TC 0 Z9 0 U1 0 U2 0 PU KARGER PI BASEL PA POSTFACH, CH-4009 BASEL, SWITZERLAND BN 978-3-8055-9584-1 PY 2011 BP 151 EP 155 PG 5 WC Respiratory System SC Respiratory System GA BSN62 UT WOS:000285026500026 ER PT J AU Triccas, JA Winter, N Feng, CG West, NP AF Triccas, James A. Winter, Nathalie Feng, Carl G. West, Nicholas P. TI Immunity to Mycobacterium tuberculosis SO CLINICAL & DEVELOPMENTAL IMMUNOLOGY LA English DT Editorial Material C1 [Triccas, James A.] Univ Sydney, Dept Infect Dis & Immunol, Sydney, NSW 2000, Australia. [Winter, Nathalie] INRA Ctr Tours, F-37380 Nouzilly, France. [Feng, Carl G.] NIAID, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA. [West, Nicholas P.] Centenary Inst Canc Med & Cell Biol, Newtown, NSW 2042, Australia. RP Triccas, JA (reprint author), Univ Sydney, Dept Infect Dis & Immunol, Sydney, NSW 2000, Australia. EM j.triccas@usyd.edu.au RI West, Nicholas/C-3119-2008 NR 2 TC 0 Z9 0 U1 0 U2 7 PU HINDAWI PUBLISHING CORPORATION PI NEW YORK PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA SN 1740-2522 J9 CLIN DEV IMMUNOL JI Clin. Dev. Immunol. PY 2011 AR 406549 DI 10.1155/2011/406549 PG 2 WC Immunology SC Immunology GA 816RD UT WOS:000294618900001 ER PT J AU Hartmann, DP Pelzel, KE Abbott, CB AF Hartmann, Donald P. Pelzel, Kelly E. Abbott, Craig B. BE Bornstein, MH Lamb, ME TI DESIGN, MEASUREMENT, AND ANALYSIS IN DEVELOPMENTAL RESEARCH SO DEVELOPMENTAL SCIENCE: AN ADVANCED TEXTBOOK, SIXTH EDITION LA English DT Article; Book Chapter ID CORRECT CONFIDENCE-INTERVALS; CHI-SQUARE TEST; PSYCHOLOGICAL-RESEARCH; QUALITATIVE RESEARCH; LONGITUDINAL DATA; MISSING DATA; NONCENTRAL DISTRIBUTIONS; INTEROBSERVER AGREEMENT; PARAMETER-ESTIMATION; LINEAR-MODELS C1 [Hartmann, Donald P.] Univ Utah, Dept Psychol, Salt Lake City, UT 84112 USA. [Pelzel, Kelly E.] Univ Iowa, Iowa City, IA 52242 USA. [Abbott, Craig B.] NICHHD, Bethesda, MD USA. RP Hartmann, DP (reprint author), Univ Utah, Dept Psychol, Salt Lake City, UT 84112 USA. NR 355 TC 6 Z9 6 U1 6 U2 8 PU ROUTLEDGE PI LONDON PA 11 NEW FETTER LANE, LONDON EC4P 4EE, ENGLAND BN 978-0-203-84676-6 PY 2011 BP 109 EP 197 PG 89 WC Psychology, Developmental SC Psychology GA BUF20 UT WOS:000289073000005 ER PT S AU Kim, IC Le, DX Thoma, GR AF Kim, In Cheol Le, Daniel X. Thoma, George R. BE Agam, G ViardGaudin, C TI Automated Identification of Biomedical Article Type Using Support Vector Machines SO DOCUMENT RECOGNITION AND RETRIEVAL XVIII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Document Recognition and Retrieval XVIII CY JAN 26-27, 2011 CL San Francisco, CA SP Soc Imaging Sci & Technol, SPIE DE "Comment-on"; "Comment-in"; Online biomedical documents; Support vector machine ID TEXT CATEGORIZATION AB Authors of short papers such as letters or editorials often express complementary opinions, and sometimes contradictory ones, on related work in previously published articles. The MEDLINE (R) citations for such short papers are required to list bibliographic data on these "commented on" articles in a "CON" field. The challenge is to automatically identify the CON articles referred to by the author of the short paper (called "Comment-in" or CIN paper). Our approach is to use support vector machines (SVM) to first classify a paper as either a CIN or a regular full-length article (which is exempt from this requirement), and then to extract from the CIN paper the bibliographic data of the CON articles. A solution to the first part of the problem, identifying CIN articles, is addressed here. We implement and compare the performance of two types of SVM, one with a linear kernel function and the other with a radial basis kernel function (RBF). Input feature vectors for the SVMs are created by combining four types of features based on statistics of words in the article title, words that suggest the article type (letter, correspondence, editorial), size of body text, and cue phrases. Experiments conducted on a set of online biomedical articles show that the SVM with a linear kernel function yields a significantly lower false negative error rate than the one with an RBF. Our experiments also show that the SVM with a linear kernel function achieves a significantly higher level of accuracy, and lower false positive and false negative error rates by using input feature vectors created by combining all four types of features rather than any single type. C1 [Kim, In Cheol; Le, Daniel X.; Thoma, George R.] Natl Lib Med, Lister Hill Natl Ctr Biomed Commun, Bethesda, MD 20894 USA. RP Kim, IC (reprint author), Natl Lib Med, Lister Hill Natl Ctr Biomed Commun, 8600 Rockville Pike, Bethesda, MD 20894 USA. EM ickim@mail.nih.gov NR 17 TC 1 Z9 1 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-411-6 J9 PROC SPIE PY 2011 VL 7874 AR 787403 DI 10.1117/12.873023 PG 9 WC Computer Science, Artificial Intelligence; Imaging Science & Photographic Technology SC Computer Science; Imaging Science & Photographic Technology GA BWF21 UT WOS:000293784300002 ER PT J AU Feghali, MN Mattison, DR AF Feghali, Maisa N. Mattison, Donald R. TI Clinical Therapeutics in Pregnancy SO JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY LA English DT Review ID CANCER RESISTANCE PROTEIN; COMPREHENSIVE ETHICAL FRAMEWORK; WASHINGTON SPECIALIZED CENTER; P-GLYCOPROTEIN EXPRESSION; HUMAN PLACENTA; PERINATAL OUTCOMES; MANAGEMENT ISSUES; EPILEPSY-FOCUS; DRUG-THERAPY; INTRAHEPATIC CHOLESTASIS AB Most drugs are not tested for use during pregnancy, consequently, labeling, which may include information about fetal safety, includes nothing about dosing, efficacy, or maternal safety. Yet these are concerns of health care providers considering treatment of disease during pregnancy. Therefore, the practitioner treats the pregnant woman with the same dose recommended for use in adults (typically men) or may decide not to treat the disease at all. However, is the choice of not treating a woman during pregnancy better than dealing with the challenges which accompany treatment? This paper, which summarizes metabolic and physiologic changes induced by pregnancy, illustrates that standard adult dosing is likely to be incorrect during pregnancy. C1 [Feghali, Maisa N.] Washington Hosp Ctr, Dept Obstet & Gynecol, Washington, DC 20010 USA. [Mattison, Donald R.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD 20892 USA. RP Feghali, MN (reprint author), Washington Hosp Ctr, Dept Obstet & Gynecol, Washington, DC 20010 USA. EM maisafeghali@gmail.com RI Mattison, Donald/L-4661-2013 OI Mattison, Donald/0000-0001-5623-0874 FU Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Health FX Funding for this paper has been provided in part by the Intramural Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Health to D. R. Mattison. NR 133 TC 21 Z9 22 U1 1 U2 5 PU HINDAWI PUBLISHING CORPORATION PI NEW YORK PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA SN 1110-7243 J9 J BIOMED BIOTECHNOL JI J. Biomed. Biotechnol. PY 2011 AR 783528 DI 10.1155/2011/783528 PG 13 WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental SC Biotechnology & Applied Microbiology; Research & Experimental Medicine GA 816YF UT WOS:000294637300001 ER PT J AU Revilleza, MJ Wang, R Mans, J Hong, MQ Natarajan, K Margulies, DH AF Revilleza, Maria Jamela Wang, Rui Mans, Janet Hong, Manqing Natarajan, Kannan Margulies, David H. TI How the Virus Outsmarts the Host: Function and Structure of Cytomegalovirus MHC-I-Like Molecules in the Evasion of Natural Killer Cell Surveillance SO JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY LA English DT Review ID INHIBITORY RECEPTOR LY49A; MURINE CYTOMEGALOVIRUS; MOUSE CYTOMEGALOVIRUS; CRYSTAL-STRUCTURE; NKG2D RECEPTOR; IMMUNE EVASION; NK CELLS; GLYCOPROTEIN UL16; INFECTED-CELLS; RAE-1 ISOFORMS AB Natural killer (NK) cells provide an initial host immune response to infection by many viral pathogens. Consequently, the viruses have evolved mechanisms to attenuate the host response, leading to improved viral fitness. Onemechanism employed bymembers of the beta-herpesvirus family, which includes the cytomegaloviruses, is to modulate the expression of cell surface ligands recognized by NK cell activation molecules. A novel set of cytomegalovirus (CMV) genes, exemplified by the mouse m145 family, encode molecules that have structural and functional features similar to those of host major histocompatibility-encoded (MHC) class I molecules, some of which are known to contribute to immune evasion. In this review, we explore the function, structure, and evolution of MHC-I-like molecules of the CMVs and speculate on the dynamic development of novel immunoevasive functions based on the MHC-I protein fold. C1 [Revilleza, Maria Jamela; Wang, Rui; Hong, Manqing; Natarajan, Kannan; Margulies, David H.] NIAID, Mol Biol Sect, Immunol Lab, NIH, Bethesda, MD 20892 USA. [Mans, Janet] Univ Witwatersrand, Dept Virol, ZA-2050 Johannesburg, South Africa. [Mans, Janet] Univ Pretoria, Dept Med Virol, ZA-0001 Pretoria, South Africa. RP Margulies, DH (reprint author), NIAID, Mol Biol Sect, Immunol Lab, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. EM dhm@nih.gov RI Margulies, David/H-7089-2013; OI Mans, Janet/0000-0001-6721-1177; Margulies, David/0000-0001-8530-7375 FU Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD FX This work was supported by the Intramural Research Program of the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD. NR 100 TC 14 Z9 14 U1 0 U2 3 PU HINDAWI PUBLISHING CORPORATION PI NEW YORK PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA SN 1110-7243 J9 J BIOMED BIOTECHNOL JI J. Biomed. Biotechnol. PY 2011 AR 724607 DI 10.1155/2011/724607 PG 12 WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental SC Biotechnology & Applied Microbiology; Research & Experimental Medicine GA 816YA UT WOS:000294636800001 ER PT B AU Isogai, S Fujita, M AF Isogai, Sumio Fujita, Misato BE Naruse, K Tanaka, M Takeda, H TI Anatomical Atlas of Blood Vascular System of Medaka SO MEDAKA: A MODEL FOR ORGANOGENESIS, HUMAN DISEASE, AND EVOLUTION LA English DT Article; Book Chapter AB The zebrafish and the medaka provide a number of advantageous features for the analysis of cardiovascular development. To fully exploit the advantages of the teleost fish, there must be detailed knowledge of the normal pattern of the vascular system from the embryo through to the adult, which enables us to detect the mutants, interpret the results of experimental or genetic perturbations, and conduct cross-species comparisons. We visualized the gill, intestinal, renal, and parietal (including brain and spinal cord) blood vascular systems in adult medaka using intravascular resin casting and dye injection methods. Here, we provide an anatomical atlas of blood vascular systems of adult fish with brief descriptions to give a morphological foundation for future cardiovascular research using the medaka. C1 [Isogai, Sumio] Iwate Med Univ, Sch Med, Dept Anat, Morioka, Iwate 0208505, Japan. [Isogai, Sumio; Fujita, Misato] NICHD, Mol Genet Lab, NIH, Bethesda, MD 20892 USA. RP Isogai, S (reprint author), Iwate Med Univ, Sch Med, Dept Anat, Morioka, Iwate 0208505, Japan. EM sisogai@iwate-med.ac.jp NR 4 TC 3 Z9 3 U1 1 U2 2 PU SPRINGER-VERLAG TOKYO PI TOKYO PA 37-3, HONGO 3-CHOME BONKYO-KU, TOKYO, 113, JAPAN BN 978-4-431-92690-0 PY 2011 BP 95 EP 109 DI 10.1007/978-4-431-92691-7_7 D2 10.1007/978-4-431-92691-7 PG 15 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA BVR90 UT WOS:000292615500007 ER PT S AU Pai, VM Stein, A Kozlowski, M George, A Kopace, R Bennett, E Auxier, JA Wen, H AF Pai, Vinay M. Stein, Ashley Kozlowski, Megan George, Ashvin Kopace, Rael Bennett, Eric Auxier, Julie A. Wen, Han BE Pelc, NJ Samei, E Nishikawa, RM TI 3D Diffraction Tomography for Visualization of Contrast Media SO MEDICAL IMAGING 2011: PHYSICS OF MEDICAL IMAGING SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Medical Imaging 2011 - Physics of Medical Imaging CY FEB 13-17, 2011 CL Lake Buena Vista, FL SP Dynasil Corp/RMD Res, Amer Assoc Physicists Med, DQE Instruments, Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc, SPIE DE diffraction; tomography; rat; contrast media; x-ray CT; lung imaging; harmonic imaging; Talbot ID SHEARING INTERFEROMETER; GRATING INTERFEROMETER; BEAM SPLITTER; RAY AB In x-ray CT, the ability to selectively isolate a contrast agent signal from the surrounding soft tissue and bone can greatly enhance contrast visibility and enable quantification of contrast concentration. We present here a 3D diffraction tomography implementation for selectively retaining volumetric diffraction signal from contrast agent particles that are within a banded size range while suppressing the background signal from soft tissue and bone. For this purpose, we developed a CT implementation of a single-shot x-ray diffraction imaging technique utilizing gratings. This technique yields both diffraction and absorption images from a single grating-modulated projection image through analysis in the spatial frequency domain. A solution of iron oxide nano-particles, having very different x-ray diffraction properties from tissue, was injected into ex vivo chicken wing and in vivo rat specimens respectively and imaged in a 3D diffraction CT setup. Following parallel beam reconstruction, it is noted that while the soft tissue, bone and contrast media are observed in the absorption volume reconstruction, only the contrast media is observed in the diffraction volume reconstruction. This 3D diffraction tomographic reconstruction permits the visualization and quantification of the contrast agent isolated from the soft tissue and bone background. C1 [Pai, Vinay M.; Kozlowski, Megan; George, Ashvin; Bennett, Eric; Wen, Han] NHLBI, NIH, Bethesda, MD 20892 USA. RP Pai, VM (reprint author), NHLBI, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. EM paiv@mail.nih.gov NR 12 TC 0 Z9 0 U1 0 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8503-8 J9 PROC SPIE PY 2011 VL 7961 AR 79611K DI 10.1117/12.877390 PG 7 WC Engineering, Electrical & Electronic; Optics; Physics, Applied; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Optics; Physics; Radiology, Nuclear Medicine & Medical Imaging GA BWL08 UT WOS:000294178500051 ER PT B AU Bassetti, M Mikulska, M Gea-Banacloche, J Viscoli, C AF Bassetti, Matteo Mikulska, Malgorzata Gea-Banacloche, Juan Viscoli, Claudio BE Safdar, A TI Invasive Candidiasis in Management of Infections in Cancer Patients SO PRINCIPLES AND PRACTICE OF CANCER INFECTIOUS DISEASES SE Current Clinical Oncology Series LA English DT Article; Book Chapter DE Candida; Beta-D-glucan; Echinocandin; Neutropenia ID LIPOSOMAL AMPHOTERICIN-B; BLOOD-STREAM INFECTIONS; DOUBLE-BLIND TRIAL; MULTICENTER RANDOMIZED-TRIAL; CLINICAL-PRACTICE GUIDELINES; SUCCESSFUL MEDICAL-TREATMENT; NON-NEUTROPENIC PATIENTS; STEM-CELL TRANSPLANTS; INTENSIVE-CARE-UNIT; BETA-D-GLUCAN AB Candida infections are increasing. Nonalbicans Candida are now the most commonly isolated species in immunocompromised patients. The determination of serum beta-D-glucan may allow early diagnosis, but the best implementation of this new technology as screening or diagnostic test remains to be determined. From the therapeutic standpoint, the echinocandins have changed the management of invasive candidiasis due to their effectiveness and excellent safety and drug interaction profile. C1 [Bassetti, Matteo; Mikulska, Malgorzata; Viscoli, Claudio] San Martino Hosp, Div Infect Dis, Genoa, Italy. [Bassetti, Matteo; Mikulska, Malgorzata; Viscoli, Claudio] Univ Genoa, Genoa, Italy. [Gea-Banacloche, Juan] NCI, Expt Transplantat & Immunol Branch, Bethesda, MD 20892 USA. RP Viscoli, C (reprint author), San Martino Hosp, Div Infect Dis, Genoa, Italy. EM viscoli@unige.it NR 84 TC 0 Z9 0 U1 0 U2 0 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA BN 978-1-60761-643-6 J9 CURR CLIN ONCOL PY 2011 BP 273 EP 281 DI 10.1007/978-1-60761-644-3_24 D2 10.1007/978-1-60761-644-3 PG 9 WC Oncology; Infectious Diseases SC Oncology; Infectious Diseases GA BVO36 UT WOS:000292077800024 ER PT B AU Rolston, KVI Greenberg, DE Safdar, A AF Rolston, Kenneth V. I. Greenberg, David E. Safdar, Amar BE Safdar, A TI Infections Caused by Aerobic and Anaerobic Gram-Negative Bacilli SO PRINCIPLES AND PRACTICE OF CANCER INFECTIOUS DISEASES SE Current Clinical Oncology Series LA English DT Article; Book Chapter DE Cancer; Pseudomonas; Stenotrophomonas; Drug-resistance; Antimicrobial therapy; E. coli ID BLOOD-STREAM INFECTIONS; FEBRILE NEUTROPENIC PATIENTS; IN-VITRO SUSCEPTIBILITY; CANCER-PATIENTS; STENOTROPHOMONAS-MALTOPHILIA; PSEUDOMONAS-AERUGINOSA; RISK-FACTORS; ANTIMICROBIAL SUSCEPTIBILITY; HEMATOLOGICAL MALIGNANCIES; ONCOLOGY PATIENTS AB Many cancer treatment centers have documented a decline in the proportion of bacterial infections caused by aerobic Gram-negative bacilli in the past 2 decades. Nevertheless, these organisms still cause a wide spectrum of infection (from benign colonization to disseminated disease) and are associated with substantial morbidity and mortality in patients with cancer, particularly during episodes of neutropenia. The most significant problem developed in the recent years has been the emergence of resistance among most Gram-negative pathogens, with some organisms acquiring multiple resistance mechanisms, which render them multi-drug-resistant. Exacerbating this problem is the fact that the pipeline for new drug development is relatively dry. This has led to the increased use of combination regimens and the revival of older agents such as colistin. Greater emphasis needs to be placed on antimicrobial stewardship and on strict adherence to infection control policies, in order to reduce the frequency of and limit the spread of these organisms. Bacteroides and other anaerobic Gram-negative bacteria may lead to life-threatening infections, presence of refractory hypotension, high-grade fever, acute intravascular hemolysis and disseminated coagulation, and early onset of tissue necrosis are the hallmark of this devastating disease. A high level of suspicion and prompt systemic therapy coupled with surgical excision of devitalized tissue when possible may improve outcomes. C1 [Rolston, Kenneth V. I.; Safdar, Amar] Univ Texas MD Anderson Canc Ctr, Dept Infect Dis Infect Control & Employee Hlth, Houston, TX 77030 USA. [Greenberg, David E.] NIAID, Dept Infect Dis, Bethesda, MD 20892 USA. RP Rolston, KVI (reprint author), Univ Texas MD Anderson Canc Ctr, Dept Infect Dis Infect Control & Employee Hlth, 1515 Holcombe Blvd,Unit 1460, Houston, TX 77030 USA. EM krolston@mdanderson.org NR 101 TC 0 Z9 0 U1 0 U2 0 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA BN 978-1-60761-643-6 J9 CURR CLIN ONCOL PY 2011 BP 423 EP 433 DI 10.1007/978-1-60761-644-3_36 D2 10.1007/978-1-60761-644-3 PG 11 WC Oncology; Infectious Diseases SC Oncology; Infectious Diseases GA BVO36 UT WOS:000292077800036 ER PT B AU Sundaram, AK Oktem, B Razumovskaya, J Jackson, SN Woods, AS Doroshenko, VM AF Sundaram, Appavu K. Oktem, Berk Razumovskaya, Jane Jackson, Shelley N. Woods, Amina S. Doroshenko, Vladimir M. BE Ivanov, AR Lazarev, AV TI Sample Preparation in Biological Analysis by Atmospheric Pressure Matrix Assisted Laser/Desorption Ionization (AP-MALDI) Mass Spectrometry SO SAMPLE PREPARATION IN BIOLOGICAL MASS SPECTROMETRY LA English DT Article; Book Chapter DE AP-MALDI MS; Proteomics; Tandem mass spectrometry; Tissue imaging; Tryptic digestion ID ION MOBILITY-TOFMS; LASER-DESORPTION/IONIZATION; BACILLUS-ANTHRACIS; ARRAY BIOSENSOR; BRAIN-TISSUE; SPORES; IDENTIFICATION; MIXTURES; PROTEINS; PEPTIDES AB Rapid detection and identification of biological molecules is of utmost importance in a number of applications including clinical diagnosis and detection of foodborne pathogens as well as environmental contaminants. Mass spectrometry affords a high degree of accuracy (specificity) and sensitivity without a need for extensive sample purification. Atmospheric-pressure matrix-assisted laser desorption/ionization (AP-MALDI) mass spectrometry has become a useful technique in a number of important applications, including identification of proteins, and structural analysis of oligosaccharides, phosphopepticles, and lipids. Sample preparation methods for AP-MALDI mass spectrometry are relatively simple, rapid and can be easily automated for high throughput sample analysis. AP-MALDI MS/MS analysis has been successfully utilized to identify the presence of different types of bioagents such as Escherichia coli (E. coli), spores of several Bacilli, Saccharomyces cerevisiae (yeast), ovalbumin, and Clostridium botulinum Neurotoxin Type A in environmental samples. AP-MALDI imaging mass spectrometry is an emerging technique for direct analysis of biological tissue sections that can be useful for profiling spatial distribution of drugs, peptides and proteins in tissue sections of plants, animals, and humans. C1 [Sundaram, Appavu K.; Oktem, Berk; Razumovskaya, Jane; Doroshenko, Vladimir M.] Sci & Engn Serv Inc, Columbia, MD 21046 USA. [Jackson, Shelley N.; Woods, Amina S.] Natl Inst Drug Abuse, Intramural Res Program, NIH, Baltimore, MD USA. RP Sundaram, AK (reprint author), Sci & Engn Serv Inc, Columbia, MD 21046 USA. EM asundaram@apmaldi.com; oktem@apmaldi.com; jrazumovski@apmaldi.com; shelley.jackson@nih.hhs.gov; awoods@intra.nida.nih.gov; dorosh@apmaldi.com NR 42 TC 0 Z9 0 U1 0 U2 6 PU SPRINGER PI DORDRECHT PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS BN 978-94-007-0758-0 PY 2011 BP 749 EP 764 DI 10.1007/978-94-007-0828-0_35 D2 10.1007/978-94-007-0828-0 PG 16 WC Biochemical Research Methods SC Biochemistry & Molecular Biology GA BVY63 UT WOS:000293148700036 ER PT B AU Yang, XP O'Shea, JJ Ghoreschi, K Laurence, A AF Yang, Xiang-Ping O'Shea, John J. Ghoreschi, Kamran Laurence, Arian BE Jiang, SP TI Signal Transduction and T(H)17 Cell Differentiation SO TH 17 CELLS IN HEALTH AND DISEASE LA English DT Article; Book Chapter ID ROR-GAMMA-T; ARYL-HYDROCARBON RECEPTOR; INTERFERON-REGULATORY FACTOR-4; HYPER-IGE SYNDROME; GROWTH-FACTOR-BETA; COLLAGEN-INDUCED ARTHRITIS; HELPER TYPE-1 CELLS; TH17 CELLS; TGF-BETA; RETINOIC-ACID AB The discovery of the interleukin (IL-)17-producing T cells (T(H)17) has markedly changed our view of T cell differentiation and T cell-mediated immunity. Characterization of the signaling pathways involved in the T(H)17 commitment has provided exciting new insights into the contributions of CD4(+) T cells to immunoregulation, host defense, and the pathogenesis of auto-immune diseases. Additionally, emerging data on conversion among polarized T helper cells have raised the question how we should view such concepts as lineage commitment, terminal differentiation, and plasticity of different T cell subtypes. The transcriptional regulatory events and epigenetic modifications that control T(H)17 cell differentiation are diverse and complex, and despite the intensive efforts on this subject, many questions remain to be answered. In this chapter, we focus on our current understanding of the signaling "pathways, molecular interactions, transcriptional events, and epigenetic modifications that result in T(H)17 differentiation and effector functions. C1 [Yang, Xiang-Ping; O'Shea, John J.; Ghoreschi, Kamran; Laurence, Arian] NIAMSD, Lymphocyte Cell Biol Sect, Mol Immunol & Inflammat Branch, NIH, Bethesda, MD 20892 USA. RP Yang, XP (reprint author), NIAMSD, Lymphocyte Cell Biol Sect, Mol Immunol & Inflammat Branch, NIH, 10 Ctr Dr,Bldg 10,Room 13C103, Bethesda, MD 20892 USA. EM yangx2@mail.nih.gov NR 148 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4419-9370-0 PY 2011 BP 157 EP 182 DI 10.1007/978-1-4419-9371-7_8 D2 10.1007/978-1-4419-9371-7 PG 26 WC Immunology SC Immunology GA BVY59 UT WOS:000293148300008 ER PT B AU Valdez, P Ouyang, WJ AF Valdez, Patricia Ouyang, Wenjun BE Jiang, SP TI The Roles of IL-22 and Its Related Family Members in the Pathogenesis of Psoriasis SO TH 17 CELLS IN HEALTH AND DISEASE LA English DT Article; Book Chapter ID PLAQUE-TYPE PSORIASIS; DIFFERENTIATION-ASSOCIATED GENE-7; II CYTOKINE RECEPTOR; INDUCER-LIKE CELLS; ROR-GAMMA-T; EPITHELIAL-CELLS; CUTTING EDGE; MELANOMA DIFFERENTIATION; INDUCIBLE FACTOR; INTERLEUKIN 22 AB IL-22 is a T(H)17 cytokine. It belongs to IL-10 family of cytokines that also includes IL-10, IL-19, IL-20, IL-24, and IL-26. IL-26 is also produced by T(H)17 cells, while IL-24 is a T(H)2 cytokine. All of these cytokines can also be produced by other leukocytes. Cytokine networks play essential roles in the pathogenesis of psoriasis. In psoriatic skin, the expression of IL-19, IL-20, IL-22, IL-24 and IL-26 is elevated. Infiltrating immune cells are the primary cellular sources. However, the receptors for these cytokines are expressed mainly on epithelial cells, including keratinocytes, but not on leukocytes. In psoriatic skin, these cytokines induce epidermal keratinocytes to display many pathogenic features, including hyperplasia, abnormal differentiation, and overexpression of psoriasin and other psoriatic markers. These cytokines mediate the crosstalk between infiltrating immune cells and epidermal keratinocytes. C1 [Ouyang, Wenjun] Genentech Inc, Dept Immunol, San Francisco, CA 94080 USA. [Valdez, Patricia] NIAID, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA. RP Ouyang, WJ (reprint author), Genentech Inc, Dept Immunol, San Francisco, CA 94080 USA. EM ouyang.wenjun@gene.com NR 117 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4419-9370-0 PY 2011 BP 445 EP 462 DI 10.1007/978-1-4419-9371-7_24 D2 10.1007/978-1-4419-9371-7 PG 18 WC Immunology SC Immunology GA BVY59 UT WOS:000293148300024 ER PT J AU Boltz, VF Ambrose, Z Kearney, M KewalRamani, V Maldarelli, F Mellors, JW Coffin, JM AF Boltz, V. F. Ambrose, Z. Kearney, M. KewalRamani, V. Maldarelli, F. Mellors, J. W. Coffin, J. M. TI Ultrasensitive allele-specific PCR reveals rare pre-existing drug-resistant variants and a large effective virus population size in macaques infected with RT-SHIV SO ANTIVIRAL THERAPY LA English DT Meeting Abstract CT International Workshop on HIV and Hepatitis Virus Drug Resistance and Curative Strategies CY JUN 07-11, 2011 CL Los Cabos, MEXICO C1 [Boltz, V. F.; Kearney, M.; KewalRamani, V.; Maldarelli, F.] NCI, Bethesda, MD 20892 USA. [Ambrose, Z.; Mellors, J. W.] Univ Pittsburgh, Pittsburgh, PA USA. [Coffin, J. M.] Tufts Univ, Boston, MA 02111 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU INT MEDICAL PRESS LTD PI LONDON PA 2-4 IDOL LANE, LONDON EC3R 5DD, ENGLAND SN 1359-6535 J9 ANTIVIR THER JI Antivir. Ther. PY 2011 VL 16 IS 4 BP A103 EP A103 PG 1 WC Infectious Diseases; Pharmacology & Pharmacy; Virology SC Infectious Diseases; Pharmacology & Pharmacy; Virology GA 813OB UT WOS:000294375700106 ER PT J AU Havens, PL Mulligan, K Hazra, R Van Loan, MD Pan, CG Bethel, J Rutledge, BN Kapogiannis, BG Flynn, PM Lujan-Zilberman, J Kiser, JJ Baker, AM Liu, NX Worrell, C Wilson, CM Stephensen, CB AF Havens, P. L. Mulligan, K. Hazra, R. Van Loan, M. D. Pan, C. G. Bethel, J. Rutledge, B. N. Kapogiannis, B. G. Flynn, P. M. Lujan-Zilberman, J. Kiser, J. J. Baker, A. M. Liu, N. X. Worrell, C. Wilson, C. M. Stephensen, C. B. CA ATN 063 Protocol Team TI Safety and efficacy of once-monthly dosing of vitamin D3 (50,000 IU) in HIV-infected youth: Adolescent Trials Network Study 063 SO ANTIVIRAL THERAPY LA English DT Meeting Abstract C1 [Havens, P. L.; Pan, C. G.] Med Coll Wisconsin, Milwaukee, WI 53226 USA. [Mulligan, K.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Hazra, R.; Kapogiannis, B. G.; Worrell, C.] Eunice Kennedy Shriver NICHD, Pediat Adolescent & Maternal AIDS Branch, NIH, Bethesda, MD USA. [Van Loan, M. D.; Stephensen, C. B.] Univ Calif Davis, USDA, Western Human Nutr Res Ctr, Davis, CA 95616 USA. [Bethel, J.; Rutledge, B. N.] Westat Corp, Bethesda, MD USA. [Flynn, P. M.] St Jude Childrens Hosp, Memphis, TN 38105 USA. [Lujan-Zilberman, J.] Univ S Florida, Coll Med, Tampa, FL USA. [Kiser, J. J.] Univ Colorado Denver, Aurora, CO USA. [Baker, A. M.] Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70118 USA. [Wilson, C. M.] Univ Alabama, Birmingham, AL USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU INT MEDICAL PRESS LTD PI LONDON PA 2-4 IDOL LANE, LONDON EC3R 5DD, ENGLAND SN 1359-6535 J9 ANTIVIR THER JI Antivir. Ther. PY 2011 VL 16 SU 2 BP A9 EP A10 PG 2 WC Infectious Diseases; Pharmacology & Pharmacy; Virology SC Infectious Diseases; Pharmacology & Pharmacy; Virology GA 813OD UT WOS:000294375900012 ER PT J AU Kearney, M Spindler, J Shao, W Stephens, R O'Shea, A Rehm, C Poethke, C Mellors, JW Coffin, JM Maldarelli, F AF Kearney, M. Spindler, J. Shao, W. Stephens, R. O'Shea, A. Rehm, C. Poethke, C. Mellors, J. W. Coffin, J. M. Maldarelli, F. TI HIV-1 populations that persist in plasma after long-term suppressive ART are more closely related to ancestral sequences than are pre-therapy populations SO ANTIVIRAL THERAPY LA English DT Meeting Abstract CT International Workshop on HIV and Hepatitis Virus Drug Resistance and Curative Strategies CY JUN 07-11, 2011 CL Los Cabos, MEXICO C1 [Kearney, M.; Spindler, J.; Poethke, C.; Maldarelli, F.] NIH, HIV Drug Resistance Program, Frederick, MD USA. [Shao, W.; Stephens, R.] SAIC, Adv Boimed Comp Ctr, Frederick, MD USA. [O'Shea, A.; Rehm, C.] NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA. [Mellors, J. W.] Univ Pittsburgh, Dept Med, Pittsburgh, PA USA. [Coffin, J. M.] Tufts Univ, Dept Mol Biol & Microbiol, Boston, MA 02111 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU INT MEDICAL PRESS LTD PI LONDON PA 2-4 IDOL LANE, LONDON EC3R 5DD, ENGLAND SN 1359-6535 J9 ANTIVIR THER JI Antivir. Ther. PY 2011 VL 16 IS 4 BP A38 EP A38 PG 1 WC Infectious Diseases; Pharmacology & Pharmacy; Virology SC Infectious Diseases; Pharmacology & Pharmacy; Virology GA 813OB UT WOS:000294375700054 ER PT J AU Larder, BA Revell, AD Wang, D Hamers, R Tempelman, H Barth, R Wensing, AMJ Morrow, C Wood, R DeWolf, F Kaiser, R Pozniak, A Lane, HC Montaner, JM AF Larder, B. A. Revell, A. D. Wang, D. Hamers, R. Tempelman, H. Barth, R. Wensing, A. M. J. Morrow, C. Wood, R. DeWolf, F. Kaiser, R. Pozniak, A. Lane, H. C. Montaner, J. M. TI Modelling response to antiretroviral therapy without a genotype as a clinical tool for resource-limited settings SO ANTIVIRAL THERAPY LA English DT Meeting Abstract CT International Workshop on HIV and Hepatitis Virus Drug Resistance and Curative Strategies CY JUN 07-11, 2011 CL Los Cabos, MEXICO C1 [Larder, B. A.; Revell, A. D.; Wang, D.] HIV Resistance Response Database Initiat RDI, London, England. [Hamers, R.] Univ Amsterdam, Acad Med Ctr, PharmAccess Fdn, NL-1105 AZ Amsterdam, Netherlands. [Tempelman, H.] Ndlovu Care Grp, Elandsdoorn, South Africa. [Barth, R.; Wensing, A. M. J.] Univ Med Ctr, Utrecht, Netherlands. [Morrow, C.; Wood, R.] Desmond Tutu HIV Ctr, Cape Town, South Africa. [DeWolf, F.] Netherlands HIV Monitoring Fdn, Amsterdam, Netherlands. [Kaiser, R.] Univ Cologne, AREVIR Cohort, Cologne, Germany. [Pozniak, A.] Chelsea & Westminster Hosp, London, England. [Lane, H. C.] NIAID, Bethesda, MD 20892 USA. [Montaner, J. M.] BC Ctr Excellence HIV AIDS, Vancouver, BC, Canada. Royal Free Hosp, London NW3 2QG, England. RI wensing, a.m.j./F-3005-2011; Wood, Robin/G-8509-2011 NR 0 TC 1 Z9 1 U1 0 U2 1 PU INT MEDICAL PRESS LTD PI LONDON PA 2-4 IDOL LANE, LONDON EC3R 5DD, ENGLAND SN 1359-6535 J9 ANTIVIR THER JI Antivir. Ther. PY 2011 VL 16 IS 4 BP A42 EP A42 PG 1 WC Infectious Diseases; Pharmacology & Pharmacy; Virology SC Infectious Diseases; Pharmacology & Pharmacy; Virology GA 813OB UT WOS:000294375700058 ER PT J AU Shao, W Wilson, E Brooks, J Dewar, R Rehman, T Kearney, M Rehm, C Metcalf, J Kottilil, S Mellors, J Coffin, J Maldarelli, F AF Shao, W. Wilson, E. Brooks, J. Dewar, R. Rehman, T. Kearney, M. Rehm, C. Metcalf, J. Kottilil, S. Mellors, J. Coffin, J. Maldarelli, F. TI Comparison of bioinformatic algorithms to identify recent HIV-1 infection SO ANTIVIRAL THERAPY LA English DT Meeting Abstract CT International Workshop on HIV and Hepatitis Virus Drug Resistance and Curative Strategies CY JUN 07-11, 2011 CL Los Cabos, MEXICO C1 [Shao, W.; Kearney, M.] SAIC, Adv Biomed Comp Ctr, Frederick, MD USA. [Wilson, E.; Maldarelli, F.] NCI, HIV Drug Resistance Program, Frederick, MD 21701 USA. [Brooks, J.; Metcalf, J.] Publ Hlth Agcy Canada, Natl HIV & Retrovirol Labs, Ottawa, ON, Canada. [Dewar, R.; Rehman, T.] NCI, Collaborat Clin Resource Branch, SAIC Frederick, Frederick, MD 21701 USA. [Rehm, C.] NIAID, Clin Res Sect, NIH, Bethesda, MD 20892 USA. [Kottilil, S.] NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA. [Mellors, J.] Univ Pittsburgh, Dept Med, Pittsburgh, PA USA. [Coffin, J.] Tufts Univ, Dept Mol Biol & Microbiol, Boston, MA 02111 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU INT MEDICAL PRESS LTD PI LONDON PA 2-4 IDOL LANE, LONDON EC3R 5DD, ENGLAND SN 1359-6535 J9 ANTIVIR THER JI Antivir. Ther. PY 2011 VL 16 IS 4 BP A155 EP A155 PG 1 WC Infectious Diseases; Pharmacology & Pharmacy; Virology SC Infectious Diseases; Pharmacology & Pharmacy; Virology GA 813OB UT WOS:000294375700147 ER PT J AU Tashima, KT Coakley, E Toma, J Mollan, KR Smeaton, L Gandhi, R Fichtenbaum, CJ Eron, JJ Andrade, A Johnson, VA Klingman, KL Manzella, A Napolitano, L Haubrich, RH AF Tashima, K. T. Coakley, E. Toma, J. Mollan, K. R. Smeaton, L. Gandhi, R. Fichtenbaum, C. J. Eron, J. J. Andrade, A. Johnson, V. A. Klingman, K. L. Manzella, A. Napolitano, L. Haubrich, R. H. TI A comparison of DNA and plasma Trofile results in a treatment-experienced study population prior to initiation of new antiretroviral regimens SO ANTIVIRAL THERAPY LA English DT Meeting Abstract CT International Workshop on HIV and Hepatitis Virus Drug Resistance and Curative Strategies CY JUN 07-11, 2011 CL Los Cabos, MEXICO C1 [Tashima, K. T.] Miriam Hosp, Providence, RI 02906 USA. [Mollan, K. R.; Smeaton, L.] Harvard Univ, Sch Publ Hlth, Ctr Biostat AIDS Res, Cambridge, MA 02138 USA. [Gandhi, R.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Fichtenbaum, C. J.] Univ Cincinnati, Cincinnati, OH 45221 USA. [Eron, J. J.] Univ N Carolina, Chapel Hill, NC 27515 USA. [Andrade, A.] Johns Hopkins Univ, Baltimore, MD 21218 USA. [Johnson, V. A.] Birmingham Vet Affairs Med Ctr, Birmingham, AL USA. [Johnson, V. A.] Univ Alabama, Med Sch Birmingham, Tuscaloosa, AL 35487 USA. [Klingman, K. L.] NIAID, HIV Res Branch TRP, DAIDS, NIH, Baltimore, MD USA. [Haubrich, R. H.] Univ Calif San Diego, San Diego, CA 92103 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU INT MEDICAL PRESS LTD PI LONDON PA 2-4 IDOL LANE, LONDON EC3R 5DD, ENGLAND SN 1359-6535 J9 ANTIVIR THER JI Antivir. Ther. PY 2011 VL 16 IS 4 BP A112 EP A112 PG 1 WC Infectious Diseases; Pharmacology & Pharmacy; Virology SC Infectious Diseases; Pharmacology & Pharmacy; Virology GA 813OB UT WOS:000294375700115 ER PT B AU Pinn, VW Blehar, MC AF Pinn, Vivian W. Blehar, Mary C. BE Rayburn, WF Schulkin, J TI Interdisciplinary Women's Health Research and Career Development SO CHANGING LANDSCAPE OF ACADEMIC WOMEN'S HEALTH CARE IN THE UNITED STATES SE International Library of Ethics Law and the New Medicine LA English DT Article; Book Chapter DE Biomedical research careers; Interdisciplinary research; Physician scientists; Women's health research; Sex differences research ID TRANSLATIONAL RESEARCH; INTERNAL-MEDICINE; OPPORTUNITIES; CHALLENGES; SCIENCE; DISEASE; MODEL AB Since the 1970s, many leaders in biomedical research have warned about a looming national shortage of new physician investigators but evidence, especially for Women's Health, has been largely indirect or anecdotal. This chapter discusses the number of junior physician investigators, in either patient-oriented or basic science research, who are present in departments and who are needed to maintain a research mission. C1 [Pinn, Vivian W.] NIH, Off Res Womens Health, US Dept HHS, Bethesda, MD 20817 USA. [Blehar, Mary C.] Off Res Womens Hlth, Potomac, MD USA. [Blehar, Mary C.] NIMH, Womens Programs, NIH, Potomac, MD USA. RP Pinn, VW (reprint author), NIH, Off Res Womens Health, US Dept HHS, Bethesda, MD 20817 USA. EM vivian.pinn@nih.gov; blehar.mary@gmail.com NR 78 TC 3 Z9 3 U1 0 U2 0 PU SPRINGER PI DORDRECHT PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS BN 978-94-007-0930-0 J9 INT LIBR ETH LAW NEW PY 2011 VL 48 BP 53 EP 75 DI 10.1007/978-94-007-0931-7_4 D2 10.1007/978-94-007-0931-7 PG 23 WC Ethics; Public, Environmental & Occupational Health; Law; Medical Ethics SC Social Sciences - Other Topics; Public, Environmental & Occupational Health; Government & Law; Medical Ethics GA BUS90 UT WOS:000290246100004 ER PT J AU Moses, JM AF Moses, Joshua M. BE Brenner, GH Bush, DH Moses, J TI An Anthropologist Among Disaster Caregivers SO CREATING SPIRITUAL AND PSYCHOLOGICAL RESILIENCE: INTEGRATING CARE IN DISASTER RELIEF WORK LA English DT Article; Book Chapter C1 [Moses, Joshua M.] CUNY, Grad Ctr, New York, NY 10021 USA. [Moses, Joshua M.] Natl Inst Mental Hlth Ruth L Kirschstein, Bethesda, MD USA. [Moses, Joshua M.] Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA. RP Moses, JM (reprint author), CUNY, Grad Ctr, New York, NY 10021 USA. NR 4 TC 1 Z9 1 U1 0 U2 1 PU ROUTLEDGE PI LONDON PA 11 NEW FETTER LANE, LONDON EC4P 4EE, ENGLAND BN 978-0-20386-953-6 PY 2011 BP 19 EP 23 PG 5 WC Psychology, Clinical; Social Work; Religion SC Psychology; Social Work; Religion GA BUP96 UT WOS:000290017600004 ER PT J AU Pandya, A AF Pandya, Anand BE Brenner, GH Bush, DH Moses, J TI Ethical and Legal Considerations in Postdisaster Interdisciplinary Collaborations SO CREATING SPIRITUAL AND PSYCHOLOGICAL RESILIENCE: INTEGRATING CARE IN DISASTER RELIEF WORK LA English DT Article; Book Chapter C1 [Pandya, Anand] NYU, Sch Med, New York, NY 10003 USA. [Pandya, Anand] Bellevue Hosp, New York, NY USA. [Pandya, Anand] Amer Psychiat Assoc, Sci Program Comm, Washington, DC 20005 USA. [Pandya, Anand] NIMH, Bethesda, MD USA. [Pandya, Anand] Cedars Sinai Med Ctr, Los Angeles, CA USA. [Pandya, Anand] Natl Alliance Mental Illness NAMI Natl, Arlington, VA USA. [Pandya, Anand] Disaster Psychiat Outreach, New York, NY USA. [Pandya, Anand] Columbia Univ, New York State Psychiat Inst, New York, NY 10027 USA. RP Pandya, A (reprint author), Univ Calif Los Angeles, Los Angeles, CA 90024 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE PI LONDON PA 11 NEW FETTER LANE, LONDON EC4P 4EE, ENGLAND BN 978-0-20386-953-6 PY 2011 BP 75 EP 82 PG 8 WC Psychology, Clinical; Social Work; Religion SC Psychology; Social Work; Religion GA BUP96 UT WOS:000290017600007 ER PT J AU Smith, RP Taylor, J Larkin, GL North, CS Ryan, D Holmes, A AF Smith, Rebecca P. Taylor, Julie Larkin, Gregory Luke North, Carol S. Ryan, Diane Holmes, Anastasia BE Brenner, GH Bush, DH Moses, J TI On Reentering the Chapel Models for Collaborations Between Psychiatrists, Communities of Faith, and Faith-Based Providers After Hurricane Katrina SO CREATING SPIRITUAL AND PSYCHOLOGICAL RESILIENCE: INTEGRATING CARE IN DISASTER RELIEF WORK LA English DT Article; Book Chapter C1 [Smith, Rebecca P.] Mt Sinai Med Ctr, New York, NY 10029 USA. [Smith, Rebecca P.] NIMH, Bethesda, MD USA. [North, Carol S.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA. [North, Carol S.] VA N Texas Hlth Care Syst, Program Trauma & Disaster, Dallas, TX USA. [Larkin, Gregory Luke] Yale Univ, Sch Med, New Haven, CT 06520 USA. [Larkin, Gregory Luke] CDC, Natl Ctr Injury Control & Prevent, Atlanta, GA 30333 USA. [Larkin, Gregory Luke] CDC, NIMH, Atlanta, GA 30333 USA. [Larkin, Gregory Luke] CDC, SAMHSA, Atlanta, GA 30333 USA. [Larkin, Gregory Luke] Guys & St Thomas NHS Trust, London, England. [Larkin, Gregory Luke] British Council, Guys St Thomas Kings Sch Med, London, England. RP Smith, RP (reprint author), Mt Sinai Med Ctr, New York, NY 10029 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE PI LONDON PA 11 NEW FETTER LANE, LONDON EC4P 4EE, ENGLAND BN 978-0-20386-953-6 PY 2011 BP 125 EP 132 PG 8 WC Psychology, Clinical; Social Work; Religion SC Psychology; Social Work; Religion GA BUP96 UT WOS:000290017600011 ER PT B AU Gullo, MJ Dawe, S McHugh, MJ AF Gullo, Matthew J. Dawe, Sharon McHugh, Meredith J. BE Bardo, MT Fishbein, DH Milich, R TI Impulsivity and Adolescent Substance Use: From Self-Report Measures to Neuroimaging and Beyond SO INHIBITORY CONTROL AND DRUG ABUSE PREVENTION: FROM RESEARCH TO TRANSLATION LA English DT Article; Book Chapter ID USE DISORDERS; PERSONALITY-TRAITS; YOUNG ADULTHOOD; BEHAVIORAL ACTIVATION; 5-HTTLPR GENOTYPE; FRONTAL-CORTEX; ALCOHOL; CHILDHOOD; METAANALYSIS; AGE AB The capacity to regulate emotional impulses and pursue appropriate long-term goals is an integral part of adaptive human functioning. Therefore, it is not surprising that this capacity consistently emerges as a core trait in biologically-based models of personality. Variously labeled as "impulsivity," "sensation seeking," or "constraint" amongst other terms, variations in this trait reliably predict the development of substance use problems in prospective studies. Notably, marked increases in this impulsivity trait appear during adolescence a period of life when substance experimentation and abuse typically begins. In recent years, neuroimaging research has identified the orbitofrontal and anterior cingulate cortices as important neural substrates of trait impulsivity. Interestingly, these same brain regions undergo substantial development during the teenage years. Indeed, there is remarkable consistency in the time course of these neural changes with those at the level of personality, suggesting both the imaging scanner and the self-report questionnaire are tapping into the same underlying construct, albeit with a differing degree of precision. Despite its far greater precision, the scanner itself cannot be practically employed in large-scale prevention programs to identify teens at risk. However, in validating the biological basis of impulsivity, along with behavioral and self-report measures of the trait, neuroimaging research allows one to use these more cost-effective tools in primary prevention with greater confidence. Indeed, there is already evidence demonstrating the ability of such "blunt" tools to focus and improve prevention programs. C1 [Dawe, Sharon] Griffith Univ, Sch Psychol, Brisbane, Qld 4101, Australia. [Gullo, Matthew J.] Univ Liverpool, Inst Psychol Hlth & Soc, Liverpool L69 7ZA, Merseyside, England. [McHugh, Meredith J.] NIDA IRP, Neuroimaging Res Branch, NIH, Baltimore, MD 21224 USA. RP Dawe, S (reprint author), Griffith Univ, Sch Psychol, Mt Gravatt Campus, Brisbane, Qld 4101, Australia. EM s.dawe@griffith.edu.au RI Gullo, Matthew/C-3850-2008 OI Gullo, Matthew/0000-0003-3657-5191 NR 67 TC 3 Z9 3 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4419-1267-1 PY 2011 BP 161 EP 175 DI 10.1007/978-1-4419-1268-8_9 D2 10.1007/978-1-4419-1268-8 PG 15 WC Psychology, Clinical; Substance Abuse; Medicine, General & Internal SC Psychology; Substance Abuse; General & Internal Medicine GA BUR10 UT WOS:000290131200009 ER PT S AU Aman, JM Yao, JH Summers, RM AF Aman, Javed M. Yao, Jianhua Summers, Ronald M. BE Summers, RM VanGinneken, B TI Automatic Colonic Polyp Shape Determination using Content-Based Image Retrieval SO MEDICAL IMAGING 2011: COMPUTER-AIDED DIAGNOSIS SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Medical Imaging 2011 - Computer-Aided Diagnosis CY FEB 15-17, 2011 CL Lake Buena Vista, FL SP SPIE, Dynasil Corp/RMD Res, Amer Assoc Physicists Med, DQE Instruments, Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc DE CT colonography; content-based image retrieval; polyp shape ID CT COLONOGRAPHY; POPULATION AB Polyp shape (sessile or pedunculated) may provide important clinical implication. However, the traditional way of determining polyp shape is both invasive and subjective. We present a less-invasive and automated method to predict the shape of colonic polyps on computed tomographic colonography (CTC) using the content-based image retrieval (CBIR) approach. We classify polyps as either sessile (SS) or pedunculated (PS) in shape. The CBIR uses numerical feature vectors generated from our CTC computer aided detection (CTC-CAD) system to describe the polyps. These features relate to physical and visual characteristics of the polyp. Feature selection was done using a support vector machine classifier on a training set of polyp shapes. The system is evaluated using an independent test set. Using receiver operating curve (ROC) analysis, we showed our system is as accurate as a polyp shape classifier. The area under the ROC curve was 0.86 (95% confidence interval [0.77, 0.93]). C1 [Aman, Javed M.; Yao, Jianhua; Summers, Ronald M.] NIH, Imaging Biomarkers & Comp Aided Diag Lab, Radiol & Imaging Sci Dept, Ctr Clin, Bethesda, MD 20892 USA. RP Aman, JM (reprint author), NIH, Imaging Biomarkers & Comp Aided Diag Lab, Radiol & Imaging Sci Dept, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA. EM jyao@cc.nih.gov NR 13 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-505-2 J9 PROC SPIE PY 2011 VL 7963 AR 79632G DI 10.1117/12.878196 PG 7 WC Engineering, Electrical & Electronic; Optics; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Optics; Radiology, Nuclear Medicine & Medical Imaging GA BWL95 UT WOS:000294211100083 ER PT S AU Caban, JJ Liao, D Yao, JH Mollura, DJ Gochuico, B Yoo, T AF Caban, Jesus J. Liao, David Yao, Jianhua Mollura, Daniel J. Gochuico, Bernadette Yoo, Terry BE Summers, RM VanGinneken, B TI Enhancing Image Classification Models with Multi-modal Biomarkers SO MEDICAL IMAGING 2011: COMPUTER-AIDED DIAGNOSIS SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Medical Imaging 2011 - Computer-Aided Diagnosis CY FEB 15-17, 2011 CL Lake Buena Vista, FL SP SPIE, Dynasil Corp/RMD Res, Amer Assoc Physicists Med, DQE Instruments, Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc DE Data fusion; Physiological values; Multi-modal biomarkers; Computer-aided Diagnosis; Pulmonary fibrosis ID COMPUTER-AIDED DIAGNOSIS; LUNG; CT AB Currently, most computer-aided diagnosis (CAD) systems rely on image analysis and statistical models to diagnose, quantify, and monitor the progression of a particular disease. In general, CAD systems have proven to be effective at providing quantitative measurements and assisting physicians during the decision-making process. As the need for more flexible and effective CADs continues to grow, questions about how to enhance their accuracy have surged. In this paper, we show how statistical image models can be augmented with multi-modal physiological values to create more robust, stable, and accurate CAD systems. In particular, this paper demonstrates how highly correlated blood and EKG features can be treated as biomarkers and used to enhance image classification models designed to automatically score subjects with pulmonary fibrosis. In our results, a 3-5% improvement was observed when comparing the accuracy of CADs that use multi-modal biomarkers with those that only used image features. Our results show that lab values such as Erythrocyte Sedimentation Rate and Fibrinogen, as well as EKG measurements such as QRS and I:40, are statistically significant and can provide valuable insights about the severity of the pulmonary fibrosis disease. C1 [Caban, Jesus J.; Liao, David; Yoo, Terry] NLM NIH, Off High Performance Comp, Bethesda, MD 20892 USA. RP Caban, JJ (reprint author), NLM NIH, Off High Performance Comp, Bethesda, MD 20892 USA. NR 13 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-505-2 J9 PROC SPIE PY 2011 VL 7963 AR 79631T DI 10.1117/12.878084 PG 9 WC Engineering, Electrical & Electronic; Optics; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Optics; Radiology, Nuclear Medicine & Medical Imaging GA BWL95 UT WOS:000294211100061 ER PT S AU Ehler, M Dobrosotskaya, J King, EJ Czaja, W Bonner, RF AF Ehler, M. Dobrosotskaya, J. King, E. J. Czaja, W. Bonner, R. F. BE Summers, RM VanGinneken, B TI Modeling Photo-bleaching Kinetics to Map Local Variations in Rod Rhodopsin Density SO MEDICAL IMAGING 2011: COMPUTER-AIDED DIAGNOSIS SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Medical Imaging 2011 - Computer-Aided Diagnosis CY FEB 15-17, 2011 CL Lake Buena Vista, FL SP SPIE, Dynasil Corp/RMD Res, Amer Assoc Physicists Med, DQE Instruments, Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc DE rhodopsin bleaching; rod density; retinal lesions; confocal scanning laser ophthalmoscope ID DARK-ADAPTATION; ELECTRORETINOGRAM; RECOVERY; PIGMENT; WAVE AB Localized rod photoreceptor and rhodopsin losses have been observed in post mortem histology both in normal aging and in age-related maculopathy. We propose to noninvasively map local rod rhodopsin density through analysis of the brightening of the underlying lipofuscin autofluorescence (LAF) in confocal scanning laser ophthalmoscopy (cSLO) imaging sequences starting in the dark adapted eye. The detected LAF increases as rhodopsin is bleached (time constant approximate to 25sec) by the average retinal irradiance of the cSLO 488nm laser beam. We fit parameters of analytical expressions for the kinetics of rhodopsin bleaching that Lamb validated using electroretinogram recordings in human. By performing localized (approximate to 100 mu m) kinetic analysis, we create high resolution maps of the rhodopsin density. This new noninvasive imaging and analysis approach appears well-suited for measuring localized changes in the rod photoreceptors and correlating them at high spatial resolution with localized pathological changes of the retinal pigment epithelium (RPE) seen in steady-state LAF images. C1 [Ehler, M.; King, E. J.; Bonner, R. F.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Sect Med Biophys, Bethesda, MD 20892 USA. RP Ehler, M (reprint author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Sect Med Biophys, 9 Mem Dr, Bethesda, MD 20892 USA. EM ehlermar@mail.nih.gov RI Bonner, Robert/C-6783-2015 NR 13 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-505-2 J9 PROC SPIE PY 2011 VL 7963 AR 79633R DI 10.1117/12.878421 PG 7 WC Engineering, Electrical & Electronic; Optics; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Optics; Radiology, Nuclear Medicine & Medical Imaging GA BWL95 UT WOS:000294211100129 ER PT S AU He, L Long, LR Antani, S Thoma, G AF He, Lei Long, L. Rodney Antani, Sameer Thoma, George BE Summers, RM VanGinneken, B TI Distribution Fitting-based Pixel Labeling for Histology Image Segmentation SO MEDICAL IMAGING 2011: COMPUTER-AIDED DIAGNOSIS SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Medical Imaging 2011 - Computer-Aided Diagnosis CY FEB 15-17, 2011 CL Lake Buena Vista, FL SP SPIE, Dynasil Corp/RMD Res, Amer Assoc Physicists Med, DQE Instruments, Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc DE Image segmentation; labeling; histology; local distribution fitting ID CLASSIFICATION; MODEL AB This paper presents a new pixel labeling algorithm for complex histology image segmentation. For each image pixel, a Gaussian mixture model is applied to estimate its neighborhood intensity distributions. With this local distribution fitting, a set of pixels having a full set of source classes (e.g. nuclei, stroma, connective tissue, and background) in their neighborhoods are identified as the seeds for pixel labeling. A seed pixel is labeled by measuring its intensity distance to each of its neighborhood distributions, and the one with the shortest distance is selected to label the seed. For non-seed pixels, we propose two different labeling schemes: global voting and local clustering. In global voting each seed classifies a non-seed pixel into one of the seed's local distributions, i.e., it casts one vote; the final label for the non-seed pixel is the class which gets the most votes, across all the seeds. In local clustering, each non-seed pixel is labeled by one of its own neighborhood distributions. Because the local distributions in a non-seed pixel neighborhood do not necessarily correspond to distinct source classes (i.e., two or more local distributions may be produced by the same source class), we first identify the "true" source class of each local distribution by using the source classes of the seed pixels and a minimum distance criterion to determine the closest source class. The pixel can then be labeled as belonging to this class. With both labeling schemes, experiments on a set of uterine cervix histology images show encouraging performance of our algorithm when compared with traditional multithresholding and K-means clustering, as well as state-of-the-art mean shift clustering, multiphase active contours, and Markov random field-based algorithms. C1 [He, Lei; Long, L. Rodney; Antani, Sameer; Thoma, George] NIH, Natl Lib Med, Bethesda, MD 20894 USA. RP He, L (reprint author), NIH, Natl Lib Med, 8600 Rockville Pike, Bethesda, MD 20894 USA. OI Antani, Sameer/0000-0002-0040-1387 NR 23 TC 1 Z9 1 U1 0 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-505-2 J9 PROC SPIE PY 2011 VL 7963 AR 79633D DI 10.1117/12.877726 PG 10 WC Engineering, Electrical & Electronic; Optics; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Optics; Radiology, Nuclear Medicine & Medical Imaging GA BWL95 UT WOS:000294211100115 ER PT S AU Liu, JM Hua, J Yao, JH White, JM Summers, RM AF Liu, Jiamin Hua, Jeremy Yao, Jianhua White, Jacob M. Summers, Ronald M. BE Summers, RM VanGinneken, B TI Computer-aided Abdominal Lymph Node Detection Using Contrast-enhanced CT Images SO MEDICAL IMAGING 2011: COMPUTER-AIDED DIAGNOSIS SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Medical Imaging 2011 - Computer-Aided Diagnosis CY FEB 15-17, 2011 CL Lake Buena Vista, FL SP SPIE, Dynasil Corp/RMD Res, Amer Assoc Physicists Med, DQE Instruments, Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc DE lymph node detection; 3D blob detector; Hessian matrix; object scale ID SEGMENTATION AB Many malignant processes cause abdominal lymphadenopathy, and computed tomography (CT) has become the primary modality for its detection. A lymph node is considered enlarged (swollen) if it is more than 1 centimeter in diameter. Which lymph nodes are swollen depends on the type of disease and the body parts involved. Identifying their locations is very important to determine the possible cause. In the current clinical workflow, the detection and diagnosis of enlarged lymph nodes is usually performed manually by examining all slices of CT images, which can be error-prone and time consuming. 3D blob enhancement filter is a usual way for computer-aided node detection. We proposed an improved blob detection method for automatic lymph node detection in contrast-enhanced abdominal CT images. First, spine was automatically extracted to indicate abdominal region. Since lymph nodes are usually next to blood vessels, abdominal blood vessels were then segmented as a reference to set the search region for lymph nodes. Next, lymph node candidates were generated by object-scale Hessian analysis. Finally the detected candidates were segmented and some prior anatomical knowledge was utilized for false positive reduction. We applied our method to 9 patients with 11 enlarged lymph nodes and compared the results with the performance of the original multi-scale Hessian analysis. The sensitivities were 91% and 82% for our method and multi-scale Hessian analysis, respectively. The false positive rates per patient were 17 and 28 for our method and multi-scale Hessian analysis, respectively. Our results indicated that computer-aided lymph node detection with this blob detector may yield a high sensitivity and a relatively low FP rate in abdominal CT. C1 [Liu, Jiamin; Hua, Jeremy; Yao, Jianhua; White, Jacob M.; Summers, Ronald M.] Natl Inst Hlth Clin Ctr, Dept Radiol & Imaging Sci, Imaging Biomarkers & Comp Aided Diag Lab, Bethesda, MD 20892 USA. RP Liu, JM (reprint author), Natl Inst Hlth Clin Ctr, Dept Radiol & Imaging Sci, Imaging Biomarkers & Comp Aided Diag Lab, Bldg 10,Room 1C368X,MSC 1182, Bethesda, MD 20892 USA. NR 17 TC 2 Z9 2 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-505-2 J9 PROC SPIE PY 2011 VL 7963 AR 796313 DI 10.1117/12.878252 PG 7 WC Engineering, Electrical & Electronic; Optics; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Optics; Radiology, Nuclear Medicine & Medical Imaging GA BWL95 UT WOS:000294211100036 ER PT S AU Wang, SJ Petrick, N Van Uitert, RL Periaswamy, S Summers, RM AF Wang, Shijun Petrick, Nicholas Van Uitert, Robert L. Periaswamy, Senthil Summers, Ronald M. BE Summers, RM VanGinneken, B TI 3D Supine and Prone Colon Registration for Computed Tomographic Colonography Scans Based on Graph Matching SO MEDICAL IMAGING 2011: COMPUTER-AIDED DIAGNOSIS SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Medical Imaging 2011 - Computer-Aided Diagnosis CY FEB 15-17, 2011 CL Lake Buena Vista, FL SP SPIE, Dynasil Corp/RMD Res, Amer Assoc Physicists Med, DQE Instruments, Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc DE Computed Tomographic Colonography; graph matching; mean-field theory; colon registration; normalized distance along the colon centerline ID CT COLONOGRAPHY AB In this paper, we propose a new registration method for supine and prone computed tomographic colonography scans based on graph matching. We first formulated 3D colon registration as a graph matching problem and utilized a graph matching algorithm based on mean field theory. During the iterative optimization process, one-to-one matching constraints were added to the system step-by-step. Prominent matching pairs found in previous iterations are used to guide subsequent mean field calculations. The advantage of the proposed method is that it does not require a colon centerline for registration. We tested the algorithm on a CTC dataset of 19 patients with 19 polyps. The average registration error of the proposed method was 4.0cm (std. 2.1cm). The 95% confidence intervals were [3.0cm, 5.0mm]. There was no significant difference between the proposed method and our previous method based on the normalized distance along the colon centerline (p=0.1). C1 [Wang, Shijun; Summers, Ronald M.] Natl Inst Hlth Clin Ctr, Imaging Biomarkers & Comp Aided Diag Lab, Bethesda, MD 20892 USA. RP Wang, SJ (reprint author), Natl Inst Hlth Clin Ctr, Imaging Biomarkers & Comp Aided Diag Lab, Bldg 10,Room 1C224,MSC 1182, Bethesda, MD 20892 USA. NR 10 TC 0 Z9 0 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-505-2 J9 PROC SPIE PY 2011 VL 7963 AR 79631F DI 10.1117/12.878227 PG 8 WC Engineering, Electrical & Electronic; Optics; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Optics; Radiology, Nuclear Medicine & Medical Imaging GA BWL95 UT WOS:000294211100047 ER PT S AU Wei, ZS Yao, JH Wang, SJ Summers, RM AF Wei, Zhuoshi Yao, Jianhua Wang, Shijun Summers, Ronald M. BE Summers, RM VanGinneken, B TI Computer-aided Teniae Coli Detection Using Height Maps from Computed Tomographic Colonography Images SO MEDICAL IMAGING 2011: COMPUTER-AIDED DIAGNOSIS SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Medical Imaging 2011 - Computer-Aided Diagnosis CY FEB 15-17, 2011 CL Lake Buena Vista, FL SP SPIE, Dynasil Corp/RMD Res, Amer Assoc Physicists Med, DQE Instruments, Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc DE CT colonography; teniae coli; Gabor filter banks ID CT COLONOGRAPHY AB Computed tomographic colonography (CTC) is a minimally invasive technique for colonic polyps and cancer screening. Teniae coli are three bands of longitudinal smooth muscle on the colon surface. They are parallel, equally distributed on the colon wall, and form a triple helix structure from the appendix to the sigmoid colon. Because of their characteristics, teniae coli are important anatomical meaningful landmarks on human colon. This paper proposes a novel method for teniae coli detection on CT colonography. We first unfold the three-dimensional (3D) colon using a reversible projection technique and compute the two-dimensional (2D) height map of the unfolded colon. The height map records the elevation of colon surface relative to the unfolding plane, where haustral folds corresponding to high elevation points and teniae to low elevation points. The teniae coli are detected on the height map and then projected back to the 3D colon. Since teniae are located where the haustral folds meet, we break down the problem by first detecting haustral folds. We apply 2D Gabor filter banks to extract fold features. The maximum response of the filter banks is then selected as the feature image. The fold centers are then identified based on piecewise thresholding on the feature image. Connecting the fold centers yields a path of the folds. Teniae coli are finally extracted as lines running between the fold paths. Experiments were carried out on 7 cases. The proposed method yielded a promising result with an average normalized RMSE of 5.66% and standard deviation of 4.79% of the circumference of the colon. C1 [Wei, Zhuoshi; Yao, Jianhua; Wang, Shijun; Summers, Ronald M.] Natl Inst Hlth Clin Ctr, Imaging Biomarkers & Comp Aided Dianosis Lab, Bethesda, MD 20892 USA. RP Wei, ZS (reprint author), Natl Inst Hlth Clin Ctr, Imaging Biomarkers & Comp Aided Dianosis Lab, Bethesda, MD 20892 USA. EM rms@nih.gov NR 13 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-505-2 J9 PROC SPIE PY 2011 VL 7963 AR 79631G DI 10.1117/12.878257 PG 8 WC Engineering, Electrical & Electronic; Optics; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Optics; Radiology, Nuclear Medicine & Medical Imaging GA BWL95 UT WOS:000294211100048 ER PT S AU Yao, JH Dwyer, AJ Summers, RM Mollura, DJ AF Yao, Jianhua Dwyer, Andrew J. Summers, Ronald M. Mollura, Daniel J. BE Summers, RM VanGinneken, B TI Computer-Aided Assessment of Pulmonary Disease in Novel Swine-Origin H1N1 Influenza on CT SO MEDICAL IMAGING 2011: COMPUTER-AIDED DIAGNOSIS SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Medical Imaging 2011 - Computer-Aided Diagnosis CY FEB 15-17, 2011 CL Lake Buena Vista, FL SP SPIE, Dynasil Corp/RMD Res, Amer Assoc Physicists Med, DQE Instruments, Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc DE H1N1 influenza; chest CT; computer aided diagnosis ID LUNG; CLASSIFICATION; INFECTION AB The 2009 pandemic is a global outbreak of novel H1N1 influenza. Radiologic images can be used to assess the presence and severity of pulmonary infection. We develop a computer-aided assessment system to analyze the CT images from Swine-Origin Influenza A virus (S-OIV) novel H1N1 cases. The technique is based on the analysis of lung texture patterns and classification using a support vector machine (SVM). Pixel-wise tissue classification is computed from the SVM value. The method was validated on four H1N1 cases and ten normal cases. We demonstrated that the technique can detect regions of pulmonary abnormality in novel H1N1 patients and differentiate these regions from visually normal lung (area under the ROC curve is 0.993). This technique can also be applied to differentiate regions infected by different pulmonary diseases. C1 [Yao, Jianhua; Dwyer, Andrew J.; Summers, Ronald M.; Mollura, Daniel J.] NIH, Radiol & Imaging Sci Dept, Ctr Clin, Bethesda, MD 20892 USA. RP Yao, JH (reprint author), NIH, Radiol & Imaging Sci Dept, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA. EM jyao@cc.nih.gov NR 18 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-505-2 J9 PROC SPIE PY 2011 VL 7963 AR 79632W DI 10.1117/12.878030 PG 7 WC Engineering, Electrical & Electronic; Optics; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Optics; Radiology, Nuclear Medicine & Medical Imaging GA BWL95 UT WOS:000294211100098 ER PT B AU Higley, JD Suomi, SJ Chaffin, AC AF Higley, J. Dee Suomi, Stephen J. Chaffin, Andrew C. BE Weiss, A King, JE Murray, L TI Impulsivity and Aggression as Personality Traits in Nonhuman Primates SO PERSONALITY AND TEMPERAMENT IN NONHUMAN PRIMATES SE Developments in Primatology-Progress and Prospects LA English DT Article; Book Chapter ID CEREBROSPINAL-FLUID MONOAMINE; MACAQUES MACACA-MULATTA; 5-HYDROXYINDOLEACETIC ACID CONCENTRATIONS; TRANSPORTER GENE VARIATION; PLASMA TESTOSTERONE LEVELS; MALE RHESUS-MONKEYS; OXIDASE-A GENE; SYSTEM SEROTONERGIC RESPONSIVITY; CERCOPITHECUS-AETHIOPS-SABAEUS; EXCESSIVE ALCOHOL-CONSUMPTION AB Studies of macaques show that aggressiveness, along with its related cousin impulsivity, is trait-like, showing stable interindividual differences across time and situations. Two variations of aggressive temperament have been described: The first, aggressive temperament or overall aggressiveness, is characterized as competitive, marked by competition and a goal to win. While competitive and aggressive, such individuals seldom engage in violence. In competitive interchanges they often emerge as winners, and are typically high in social dominance. A second type of aggressive temperament leads to impulsive and unrestrained violence. This form of aggression has a strong relationship with impulse-control deficits. Evidence suggests that the two different forms of aggressiveness are mediated by differing systems, with competitive aggression mediated by testosterone. Impulsive aggression is mediated, at least in part by deficits in the serotonin system, with clear genetic and environmental underpinnings. These serotonin-impaired macaques show a variety of antisocial-like personality differences, exhibiting social alienation, sociosexual impairments, as well as impulse-control deficits, violence, and premature death, typically due to violent means. A variety of new molecular genetic studies show that the second form of aggressiveness is modulated, at least in part, by genetic x environmental interactions. C1 [Higley, J. Dee; Chaffin, Andrew C.] Brigham Young Univ, Dept Psychol, Provo, UT 84602 USA. [Suomi, Stephen J.] NICHHD, Comparat Ethol Lab, Bethesda, MD 20892 USA. RP Higley, JD (reprint author), Brigham Young Univ, Dept Psychol, 1042 SWKT, Provo, UT 84602 USA. EM james_higley@byu.edu; suomis@lce.nichd.nih.gov; andrew_chaffin@byu.edu NR 170 TC 5 Z9 5 U1 1 U2 17 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4614-0175-9 J9 DEV PRIMATOL-PROG PR JI Dev Primatol PY 2011 BP 257 EP 283 DI 10.1007/978-1-4614-0176-6_10 D2 10.1007/978-1-4614-0176-6 PG 27 WC Behavioral Sciences; Zoology SC Behavioral Sciences; Zoology GA BWO19 UT WOS:000294382600010 ER PT B AU Suomi, SJ Chaffin, AC Higley, JD AF Suomi, Stephen J. Chaffin, Andrew C. Higley, J. Dee BE Weiss, A King, JE Murray, L TI Reactivity and Behavioral Inhibition as Personality Traits in Nonhuman Primates SO PERSONALITY AND TEMPERAMENT IN NONHUMAN PRIMATES SE Developments in Primatology-Progress and Prospects LA English DT Article; Book Chapter ID MONKEYS MACACA-MULATTA; INFANT RHESUS-MONKEYS; 5-HYDROXYINDOLEACETIC ACID CONCENTRATIONS; CORTICOTROPIN-RELEASING HORMONE; TRANSPORTER GENE VARIATION; CEREBROSPINAL-FLUID MONOAMINE; EXCESSIVE ALCOHOL-CONSUMPTION; POSITRON-EMISSION-TOMOGRAPHY; DIMINISHED SOCIAL COMPETENCE; FRONTAL BRAIN ACTIVITY AB While the history of the study of personality dates back to the early 1900s, most animal research, particularly on nonhuman primates, is much more recent. That personality in animals reflects our common evolutionary history is not surprising, and given our close genetic relatedness, should be expected. The personality trait that has received the most research in nonhuman primates is what we have called elsewhere, reactivity (others have referred to it as fearfulness, timidity, shyness, etc.). While several methods have been used to study it (including personality rating scales), generally, reactivity in nonhuman primates is most often measured using behavior codings. Two paradigms have received the most research: social separations and the human intruder paradigm. Individual differences in reactivity are stable across time and situations. Reactivity can also predict multiple behavioral outcomes, including enduring anxiety, low social dominance rank and submissiveness, high alcohol intake, and other forms of affective psychopathology. One major advantage of using nonhuman primates to model personality is that the underlying physiology and central nervous system foundations can be more readily studied than in humans. These studies show the importance of the amygdala and frontal cortex, as well as the HPA Axis, central norepinephrine, and serotonin in regulating reactivity. Studies also show the importance of early parental influence and genes on reactivity. Recent studies using molecular genetics show that the serotonin transporter and corticotrophin releasing hormone genes probably play important roles in its etiology but interact with early rearing history and situations to modulate reactivity. C1 [Suomi, Stephen J.] NICHHD, Comparat Ethol Lab, Bethesda, MD 20892 USA. [Chaffin, Andrew C.; Higley, J. Dee] Brigham Young Univ, Dept Psychol, Provo, UT 84602 USA. RP Suomi, SJ (reprint author), NICHHD, Comparat Ethol Lab, 6105 Rockledge Dr,Suite 8030,MSC 7971, Bethesda, MD 20892 USA. EM suomis@lce.nichd.nih.gov; andrew_chaffin@byu.edu; james_higley@byu.edu NR 185 TC 2 Z9 2 U1 3 U2 11 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4614-0175-9 J9 DEV PRIMATOL-PROG PR JI Dev Primatol PY 2011 BP 285 EP 311 DI 10.1007/978-1-4614-0176-6_11 D2 10.1007/978-1-4614-0176-6 PG 27 WC Behavioral Sciences; Zoology SC Behavioral Sciences; Zoology GA BWO19 UT WOS:000294382600011 ER PT J AU Kessler, RC Aguilar-Gaxiola, S Alonso, J Chatterji, S Lee, S Levinson, D Ormel, J Ustun, TB Wang, PS AF Kessler, Ronald C. Aguilar-Gaxiola, Sergio Alonso, Jordi Chatterji, Somnath Lee, Sing Levinson, Daphna Ormel, Johan Uestuen, T. Bedirhan Wang, Philip S. BE Cohen, N Galea, S TI The burden of mental disorders worldwide Results from the World Mental Health surveys SO POPULATION MENTAL HEALTH: EVIDENCE, POLICY, AND PUBLIC HEALTH PRACTICE SE Routledge Studies in Public Health LA English DT Article; Book Chapter ID OF-THE-LITERATURE; PSYCHIATRIC-DISORDERS; ECONOMIC BURDEN; SOCIAL-CONSEQUENCES; SURVEY REPLICATION; ANXIETY DISORDERS; GLOBAL ASSESSMENT; MOOD DISORDERS; PREVALENCE; DISABILITY C1 [Kessler, Ronald C.] Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA. [Aguilar-Gaxiola, Sergio] Univ Calif Davis, Ctr Reducing Hlth Dispar, Sch Med, Sacramento, CA 95817 USA. [Aguilar-Gaxiola, Sergio] Univ Calif Davis, Clin & Translat Sci Ctr, Sch Med, Sacramento, CA 95817 USA. [Alonso, Jordi] Hosp Mar, Hlth Serv Res Unit, IMEM, Res Inst, Barcelona, Spain. [Alonso, Jordi] CIBERESP, Barcelona, Spain. [Chatterji, Somnath] WHO, Dept Measurement & Hlth Informat Syst, CH-1211 Geneva, Switzerland. [Lee, Sing] Chinese Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China. [Levinson, Daphna] Minist Hlth, Mental Hlth Serv, Jerusalem, Israel. [Ormel, Johan] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat & Psychiat Epidemiol, Univ Ctr Psychiat, NL-9713 AV Groningen, Netherlands. [Uestuen, T. Bedirhan] WHO, EIP HFS, CH-1211 Geneva, Switzerland. [Wang, Philip S.] NIMH, Bethesda, MD 20892 USA. RP Kessler, RC (reprint author), Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA. RI Lee, Sing/O-2136-2015 NR 59 TC 0 Z9 0 U1 1 U2 4 PU ROUTLEDGE PI LONDON PA 11 NEW FETTER LANE, LONDON EC4P 4EE, ENGLAND BN 978-0-203-81861-9 J9 ROUT STUD PUB HLTH PY 2011 BP 9 EP 37 PG 29 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA BUV82 UT WOS:000290474800002 ER PT J AU Druss, BG Wang, PS Kessler, RC AF Druss, Benjamin G. Wang, Philip S. Kessler, Ronald C. BE Cohen, N Galea, S TI Mental health service utilization in the United States Past, present, and future SO POPULATION MENTAL HEALTH: EVIDENCE, POLICY, AND PUBLIC HEALTH PRACTICE SE Routledge Studies in Public Health LA English DT Article; Book Chapter ID FEDERAL-EMPLOYEES; INSURANCE PARITY; CARE; DISORDERS; TRENDS; ILLNESS; PSYCHOTHERAPY; INCENTIVES; PREVALENCE; MOVEMENTS C1 [Druss, Benjamin G.] Emory Univ, Dept Hlth Policy & Management, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Wang, Philip S.] NIMH, Bethesda, MD 20892 USA. [Kessler, Ronald C.] Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA. RP Druss, BG (reprint author), Emory Univ, Dept Hlth Policy & Management, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. NR 42 TC 0 Z9 0 U1 0 U2 3 PU ROUTLEDGE PI LONDON PA 11 NEW FETTER LANE, LONDON EC4P 4EE, ENGLAND BN 978-0-203-81861-9 J9 ROUT STUD PUB HLTH PY 2011 BP 195 EP 205 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA BUV82 UT WOS:000290474800011 ER PT B AU Jerome, LW AF Jerome, Leigh W. BE Saad, M Zawdie, G TI Triple Helix Knowledge Clusters Accelerating Innovation and Creating Transformative Networks SO THEORY AND PRACTICE OF THE TRIPLE HELIX SYSTEM IN DEVELOPING COUNTRIES: ISSUES AND CHALLENGES SE Routledge Studies in Innovation Organization and Technology LA English DT Article; Book Chapter ID GLOBAL HEALTH; TECHNOLOGY; MODEL C1 [Jerome, Leigh W.] Inst Triple Helix Innovat, Honolulu, HI 96822 USA. [Jerome, Leigh W.] Amer Psychol Assoc, Washington, DC USA. [Jerome, Leigh W.] WHO, Geneva, Switzerland. [Jerome, Leigh W.] NIH, Bethesda, MD 20892 USA. RP Jerome, LW (reprint author), Inst Triple Helix Innovat, Honolulu, HI 96822 USA. NR 58 TC 0 Z9 0 U1 0 U2 4 PU ROUTLEDGE PI LONDON PA 11 NEW FETTER LANE, LONDON EC4P 4EE, ENGLAND BN 978-0-203-83821-1; 978-0-415-47516-7 J9 ROUT STUD INNOV ORG PY 2011 VL 16 BP 9 EP 24 PG 16 WC Economics; Operations Research & Management Science SC Business & Economics; Operations Research & Management Science GA BUU46 UT WOS:000290378100002 ER PT B AU Tullius, TD Parker, SCJ Margulies, EH AF Tullius, Thomas D. Parker, Stephen C. J. Margulies, Elliott H. BE Pontarotti, P TI Evolutionary Constraint on DNA Shape in the Human Genome SO EVOLUTIONARY BIOLOGY: CONCEPTS, BIODIVERSITY, MACROEVOLUTION AND GENOME EVOLUTION LA English DT Proceedings Paper CT 14th Evolutionary Biology Meeting CY SEP 21-24, 2010 CL Marseilles, FRANCE ID FUNCTIONAL ELEMENTS; IDENTIFICATION; RECOGNITION; PROJECT; SPECIFICITY; MODENCODE; 1-PERCENT; BINDING AB In the age of genomics, DNA is depicted as a string of letters. While this is a useful device for representing the information in a genome, the molecular nature of DNA is obscured. Proteins cannot actually "read" DNA letters they discriminate between DNA binding sites via molecular recognition, which is sensitive to DNA structure. Since shape is essential to DNA's biological function, we hypothesized that natural selection can act to preserve DNA shape without maintaining the exact sequence of nucleotides. To test this hypothesis, we developed a DNA structure database, ORChID, and used it to map structural variation throughout the human genome. We then devised a computational algorithm, Chai, to detect evolutionary constraint on DNA shape. We found that Chai regions correlate better with experimental functional elements than do genomic regions that are sequence-constrained. Our results support the hypothesis that DNA shape can be a substrate for natural selection. C1 [Tullius, Thomas D.] Boston Univ, Dept Chem, 590 Commonwealth Ave, Boston, MA 02215 USA. [Tullius, Thomas D.; Parker, Stephen C. J.] Boston Univ, Program Bioinform, Boston, MA 02215 USA. [Parker, Stephen C. J.; Margulies, Elliott H.] NHGRI, Genome Inform Sec, Genome Tech Branch, NIH, Bethesda, MD 20892 USA. RP Tullius, TD (reprint author), Boston Univ, Dept Chem, 590 Commonwealth Ave, Boston, MA 02215 USA. EM tullius@bu.edu; stephen.parker@nih.gov; elliott@nhgri.nih.gov RI Tullius, Thomas/A-9685-2008 OI Tullius, Thomas/0000-0003-4425-796X FU National Human Genome Research Institute (NHGRI) of the NIH [R01 HG003541]; Intramural Research Program of the NHGRI, NIH; National Academies Ford Foundation Dissertation Fellowship FX This work was funded by a grant to T.D.T. from the National Human Genome Research Institute (NHGRI) of the NIH (R01 HG003541). E.H.M. was supported by the Intramural Research Program of the NHGRI, NIH. S.C.J.P. was the recipient of a National Academies Ford Foundation Dissertation Fellowship. NR 19 TC 0 Z9 0 U1 0 U2 2 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY BN 978-3-642-20762-4 PY 2011 BP 243 EP + DI 10.1007/978-3-642-20763-1_14 PG 3 WC Evolutionary Biology SC Evolutionary Biology GA BWF66 UT WOS:000293822500014 ER PT S AU Bagci, U Udupa, JK Chen, XJ AF Bagci, Ulas Udupa, Jayaram K. Chen, Xinjian BE Dawant, BM Haynor, DR TI Orientation Estimation of Anatomical Structures in Medical Images for Object Recognition SO MEDICAL IMAGING 2011: IMAGE PROCESSING SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Medical Imaging 2011 - Image Processing CY FEB 14-16, 2011 CL Lake Buena Vista, FL SP Dynasil Corp/RMD Res, Amer Assoc Physicists Med, DQE Instruments Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc, SPIE DE Anatomy Segmentation; Object Recognition; Hermitian Matrices; Non-Euclidean metrics; Multiple Object Recognition AB Recognition of anatomical structures is an important step in model based medical image segmentation. It provides pose estimation of objects and information about "where" roughly the objects are in the image and distinguishing them from other object-like entities. In,(1) we presented a general method of model-based multiobject recognition to assist in segmentation (delineation) tasks. It exploits the pose relationship that can be encoded, via the concept of ball scale (b-scale), between the binary training objects and their associated grey images. The goal was to place the model, in a single shot, close to the right pose (position, orientation, and scale) in a given image so that the model boundaries fall in the close vicinity of object boundaries in the image. Unlike position and scale parameters, we observe that orientation parameters require more attention when estimating the pose of the model as even small differences in orientation parameters can lead to inappropriate recognition. Motivated from the non-Euclidean nature of the pose information, we propose in this paper the use of non-Euclidean metrics to estimate orientation of the anatomical structures for more accurate recognition and segmentation. We statistically analyze and evaluate the following metrics for orientation estimation: Euclidean, Log-Euclidean, Root-Euclidean, Procrustes Size-and-Shape, and mean Hermitian metrics. The results show that mean Hermitian and Cholesky decomposition metrics provide more accurate orientation estimates than other Euclidean and non-Euclidean metrics. C1 [Bagci, Ulas] NIH, Ctr Clin, Bethesda, MD 20814 USA. RP Bagci, U (reprint author), NIH, Ctr Clin, Off 1C370, Bethesda, MD 20814 USA. EM ulasbagci@ieee.org OI Bagci, Ulas/0000-0001-7379-6829 NR 7 TC 1 Z9 1 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-504-5 J9 PROC SPIE PY 2011 VL 7962 AR 79622L DI 10.1117/12.878184 PG 9 WC Engineering, Electrical & Electronic; Optics; Physics, Applied; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Optics; Physics; Radiology, Nuclear Medicine & Medical Imaging GA BWK52 UT WOS:000294154900091 ER PT S AU Chen, XJ Summers, RM Yao, JH AF Chen, Xinjian Summers, Ronald M. Yao, Jianhua BE Dawant, BM Haynor, DR TI Automatic 3D Kidney Segmentation Based on Shape Constrained GC-OAAM SO MEDICAL IMAGING 2011: IMAGE PROCESSING SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Medical Imaging 2011 - Image Processing CY FEB 14-16, 2011 CL Lake Buena Vista, FL SP Dynasil Corp/RMD Res, Amer Assoc Physicists Med, DQE Instruments Inc, Ocean Thin Films, Inc, Univ Cent Florida, CREOL - Coll Opt & Photon, VIDA Diagnost, Inc, SPIE DE Kidney Segmentation; Active Appearance Models; Graph Cut; Live Wire ID ALGORITHMS; FRAMEWORK AB kidney can be classified into three main tissue types: renal cortex, renal medulla and renal pelvis (or collecting system). Dysfunction of different renal tissue types may cause different kidney diseases. Therefore, accurate and efficient segmentation of kidney into different tissue types plays a very important role in clinical research. In this paper, we propose an automatic 3D kidney segmentation method which segments the kidney into the three different tissue types: renal cortex, medulla and pelvis. The proposed method synergistically combines active appearance model (AAM), live wire (LW) and graph cut (GC) methods, GC-OAAM for short. Our method consists of two main steps. First, a pseudo 3D segmentation method is employed for kidney initialization in which the segmentation is performed slice-by-slice via a multi-object oriented active appearance model (OAAM) method. An improved iterative model refinement algorithm is proposed for the AAM optimization, which synergistically combines the AAM and LW method. Multi-object strategy is applied to help the object initialization. The 3D model constraints are applied to the initialization result. Second, the object shape information generated from the initialization step is integrated into the GC cost computation. A multi-label GC method is used to segment the kidney into cortex, medulla and pelvis. The proposed method was tested on 19 clinical arterial phase CT data sets. The preliminary results showed the feasibility and efficiency of the proposed method. C1 [Chen, Xinjian; Summers, Ronald M.; Yao, Jianhua] NIH, Radiol & Imaging Sci Dept, Ctr Clin, Bethesda, MD 20892 USA. RP Chen, XJ (reprint author), NIH, Radiol & Imaging Sci Dept, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA. EM chenx6@mail.nih.gov; jyao@mail.nih.gov NR 18 TC 0 Z9 0 U1 0 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-504-5 J9 PROC SPIE PY 2011 VL 7962 AR 79623M DI 10.1117/12.878062 PG 8 WC Engineering, Electrical & Electronic; Optics; Physics, Applied; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Optics; Physics; Radiology, Nuclear Medicine & Medical Imaging GA BWK52 UT WOS:000294154900127 ER PT B AU Elfrey, MK Zieman, SJ AF Elfrey, M. Kate Zieman, Susan J. BE Katlic, MR TI Anticoagulation in the Older Surgical Patient SO CARDIOTHORACIC SURGERY IN THE ELDERLY LA English DT Article; Book Chapter DE Anticoagulation; Heparin; Bleeding; DVT prophylaxis; Warfarin; Direct thrombin inhibitors; Prosthetic valves ID CORONARY-ARTERY-DISEASE; DEEP-VEIN THROMBOSIS; VENA-CAVA FILTERS; ATRIAL-FIBRILLATION; PULMONARY-EMBOLISM; INTRACRANIAL HEMORRHAGE; ANTITHROMBOTIC THERAPY; STROKE PREVENTION; CLINICAL-PRACTICE; GUIDELINE UPDATE AB This chapter covers the delicate balance of the use of anticoagulation in older surgical patients, including those undergoing cardiothoracic (CT) surgery, and those with existing prosthetic valves who undergo other surgeries. Increasing age, alone, augments the risk of thromboembolic events in addition to comorbidities commonly seen in older patients (prior stroke, diabetes, atrial fibrillation and cancer). Older patients are also more prone to bleeding due to inadvertent over-anticoagulation, comorbidites (GI bleeding), and other medications affecting bleeding. Managing the older surgical patient on chronic oral anticoagulation therapy (OAT), when to stop therapy, when to use bridging therapy with heparin, when and how to reverse OAT, and how to resume OAT is covered. This section includes recommendations for patients with prosthetic heart valves. Strategies for venothromoembolism (VTE) prophylaxis in the perioperative period of specific surgeries is presented with multiple agents. Lastly, post-surgical conditions requiring anticoagulation such as VTE, atrial fibrillation, myocardial infarction, and valve implantation are presented. Age-specific reductions in warfarin loading and maintenance doses as well as strategies to reduce major bleeding events and intracranial hemorrhage are covered. C1 [Zieman, Susan J.] NIA, NIH, Bethesda, MD 20892 USA. [Elfrey, M. Kate] Johns Hopkins Bayview Hosp, Dept Internal Med, Baltimore, MD 21224 USA. RP Zieman, SJ (reprint author), NIA, NIH, 7201 Wisconsin Ave,Suite 3C307, Bethesda, MD 20892 USA. EM susan.zieman@nih.gov NR 59 TC 0 Z9 0 U1 1 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4419-0891-9 PY 2011 BP 221 EP 239 DI 10.1007/978-1-4419-0892-6_17 D2 10.1007/978-1-4419-0892-6 PG 19 WC Cardiac & Cardiovascular Systems; Surgery SC Cardiovascular System & Cardiology; Surgery GA BVJ10 UT WOS:000291632500017 ER PT B AU Johnson, JL Hrynkow, S AF Johnson, Joy L. Hrynkow, Sharon BE Kirst, M SchaeferMcDaniel, N Hwang, S OCampo, P TI Funding Agencies and Transdisciplinary Research SO CONVERGING DISCIPLINES: A TRANSDISCIPLINARY RESEARCH APPROACH TO URBAN HEALTH PROBLEMS LA English DT Article; Book Chapter C1 [Johnson, Joy L.] Univ British Columbia, Canadian Inst Hlth Res, Inst Gender & Hlth, Vancouver, BC V5Z 1M9, Canada. [Johnson, Joy L.] Univ British Columbia, Sch Nursing, Vancouver, BC V5Z 1M9, Canada. [Hrynkow, Sharon] Natl Inst Environm Hlth Sci, NIH, Res Triangle Pk, NC 27709 USA. RP Johnson, JL (reprint author), Univ British Columbia, Canadian Inst Hlth Res, Inst Gender & Hlth, Vancouver, BC V5Z 1M9, Canada. NR 8 TC 1 Z9 1 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4419-6329-1 PY 2011 BP 149 EP 160 DI 10.1007/978-1-4419-6330-7_11 D2 10.1007/978-1-4419-6330-7 PG 12 WC Public, Environmental & Occupational Health; Urban Studies SC Public, Environmental & Occupational Health; Urban Studies GA BSN40 UT WOS:000285021000011 ER PT J AU Han, HJ Park, SJ Soh, KS Myoung, HS Lee, KJ Ogay, V Lee, YH AF Han, Hyun-Jung Park, Sang-Jun Soh, Kwang-sup Myoung, Hyoun-Seok Lee, Kyoung-Joung Ogay, Vyacheslav Lee, Yong-Heum TI Electrical Characterization of Proposed Transpositional Acupoints on the Urinary Bladder Meridian in a Rat Model SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE LA English DT Article ID NEUROPEPTIDE-Y EXPRESSION; ACUPUNCTURE POINTS; IMPEDANCE; LOCI; STIMULATION; SKIN AB Specific electrical characteristics of acupoints were investigated on the urinary bladder (BL) meridian in 14 rats. BL acupoints and non-acupoints on the back were selected and their electrical voltages were measured by using a SPAC system. The mean voltages of each point or each line were statistically analyzed by using the ANOVA test. The BL meridian showed voltages higher than those of the reference line (P < .05). Bilateral 1st BL lines presented higher voltages than bilateral 2nd BL lines (P < .05). Most BL acupoints had voltages higher than those for the corresponding reference points (P < .05). In particular, the right BL16 exhibited the biggest difference from the reference point, followed by the left extra BL point-2, the right BL27, the left BL17, and the left BL45. Additionally, the distributions of neurofilamentsfor several points were investigated by using immunohistochemistry. There was a trend for the BL acupoints to have larger numbers of neurofilaments than the reference points, and that trend seemed to be directly proportional to the difference in voltage between the points. In conclusion, BL acupoints on the back in ratsexhibited specific electric and histologic characteristics. Therefore, those acupointsmay be utilized to investigate the efficacy of acupuncture with laboratory animals. C1 [Myoung, Hyoun-Seok; Lee, Kyoung-Joung; Lee, Yong-Heum] Yonsei Univ, Dept Biomed Engn, Wonju 220710, Gangwon Do, South Korea. [Han, Hyun-Jung; Park, Sang-Jun; Soh, Kwang-sup] Seoul Natl Univ, Dept Phys & Astron, Biomed Phys Lab, Seoul 151747, South Korea. [Han, Hyun-Jung; Park, Sang-Jun; Soh, Kwang-sup] Seoul Natl Univ, Ctr Theoret Phys, Seoul 151747, South Korea. [Ogay, Vyacheslav] Natl Biotechnol Ctr, Lab Immunochem & Immunobiotechnol, Astana 010000, Kazakhstan. RP Lee, YH (reprint author), Yonsei Univ, Dept Biomed Engn, 234 Maeji Ri, Wonju 220710, Gangwon Do, South Korea. EM koaim@yonsei.ac.kr OI Soh, Kwang-Sup/0000-0001-8776-7877 FU Ministry of Commerce, Industry, and Energy of the Korean Government [10028424] FX This research was supported by a Grant from the Next Generation New Technology Development Program (10028424) funded by the Ministry of Commerce, Industry, and Energy of the Korean Government. NR 35 TC 2 Z9 2 U1 0 U2 3 PU HINDAWI PUBLISHING CORPORATION PI NEW YORK PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA SN 1741-427X J9 EVID-BASED COMPL ALT JI Evid.-based Complement Altern. Med. PY 2011 AR 295475 DI 10.1155/2011/295475 PG 8 WC Integrative & Complementary Medicine SC Integrative & Complementary Medicine GA 801AL UT WOS:000293408700001 ER PT B AU Okunieff, P Sundararaman, S Metcalfe, S Chen, Y AF Okunieff, Paul Sundararaman, Srinath Metcalfe, Su Chen, Yuhchyau BE Gunderson, LL Willett, CG Calvo, FA Harrison, LB TI Biology of Large Dose per Fraction Irradiation SO INTRAOPERATIVE IRRADIATION: TECHNIQUES AND RESULTS, SECOND EDITION SE Current Clinical Oncology Series LA English DT Article; Book Chapter DE Radiobiology of IORT; Tumor oxygenation; Hypoxic radiation sensitization ID INTRAOPERATIVE RADIATION-THERAPY; BONE-MARROW-TRANSPLANTATION; ADVANCED BREAST-CANCER; HYPOXIC TUMOR-CELLS; DNA TOPOISOMERASE-I; LARGE ANIMAL-MODEL; MURINE FIBROSARCOMA; LOCAL IRRADIATION; MAMMARY-CARCINOMA; PERIPHERAL-NERVE C1 [Okunieff, Paul] Univ Florida, Dept Radiat Oncol, Gainesville, FL 32610 USA. [Metcalfe, Su; Chen, Yuhchyau] Univ Rochester, Sch Med & Dent, Dept Radiat Oncol, Rochester, NY 14642 USA. [Sundararaman, Srinath] NCI, Radiat Oncol Branch, Hollywood, FL 33021 USA. RP Okunieff, P (reprint author), Univ Florida, Dept Radiat Oncol, 2033 Mowry Rd,Suite 145,POB 103633, Gainesville, FL 32610 USA. EM Pokunieff@ufl.edu NR 111 TC 4 Z9 4 U1 0 U2 1 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA BN 978-1-61779-014-0 J9 CURR CLIN ONCOL PY 2011 BP 27 EP 47 DI 10.1007/978-1-61779-015-7_2 D2 10.1007/978-1-61779-015-7 PG 21 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA BVL63 UT WOS:000291828200002 ER PT J AU Goldstein, BA Polley, EC Briggs, FBS AF Goldstein, Benjamin A. Polley, Eric C. Briggs, Farren B. S. TI Random Forests for Genetic Association Studies SO STATISTICAL APPLICATIONS IN GENETICS AND MOLECULAR BIOLOGY LA English DT Article DE machine learning; SNP; genome wide association studies ID GENOME-WIDE ASSOCIATION; VARIABLE IMPORTANCE; LOGISTIC-REGRESSION; MULTIPLE-SCLEROSIS; SELECTION; CLASSIFICATION; SNPS; BIAS AB The Random Forests (RF) algorithm has become a commonly used machine learning algorithm for genetic association studies. It is well suited for genetic applications since it is both computationally efficient and models genetic causal mechanisms well. With its growing ubiquity, there has been inconsistent and less than optimal use of RF in the literature. The purpose of this review is to breakdown the theoretical and statistical basis of RF so that practitioners are able to apply it in their work. An emphasis is placed on showing how the various components contribute to bias and variance, as well as discussing variable importance measures. Applications specific to genetic studies are highlighted. To provide context, RF is compared to other commonly used machine learning algorithms. C1 [Goldstein, Benjamin A.] Stanford Univ, Dept Med, Quantitat Sci Unit, Stanford, CA 94305 USA. [Polley, Eric C.] NCI, Biometr Res Branch, NIH, Bethesda, MD 20892 USA. [Briggs, Farren B. S.] Univ Calif Berkeley, Genet Epidemiol & Genom Lab, Berkeley, CA 94720 USA. RP Goldstein, BA (reprint author), Stanford Univ, Dept Med, Quantitat Sci Unit, Stanford, CA 94305 USA. FU National Institutes of Health NRSA [T32 HG 00047]; Russell M. Grossman Endowment FX Benjamin A. Goldstein, Quantitative Sciences Unit, Department of Medicine, Stanford University. Eric C. Polley, Biometric Research Branch, National Cancer Institute, National Institutes of Health. Farren B. S. Briggs, Genetic Epidemiology and Genomics Laboratory, University of California, Berkeley. The authors acknowledge Alan Hubbard, Lisa Barcellos and Adele Cutler for discussing and reviewing aspects of this work. BAG was funded in part by a National Institutes of Health NRSA Trainee appointment on grant T32 HG 00047 and the Russell M. Grossman Endowment. FBSB is a National Multiple Sclerosis Society PostDoctoral Fellow (FG 1847A1/1) NR 65 TC 21 Z9 21 U1 3 U2 15 PU BERKELEY ELECTRONIC PRESS PI BERKELEY PA 2809 TELEGRAPH AVENUE, STE 202, BERKELEY, CA 94705 USA SN 1544-6115 J9 STAT APPL GENET MOL JI Stat. Appl. Genet. Mol. Biol. PY 2011 VL 10 IS 1 AR 32 DI 10.2202/1544-6115.1691 PG 35 WC Biochemistry & Molecular Biology; Mathematical & Computational Biology; Statistics & Probability SC Biochemistry & Molecular Biology; Mathematical & Computational Biology; Mathematics GA 800XY UT WOS:000293402200005 PM 22889876 ER PT B AU Silva, GS Koroshetz, WJ Gonzalez, RG Schwamm, LH AF Silva, Gisele S. Koroshetz, Walter J. Gonzalez, R. Gilberto Schwamm, Lee H. BE Gonzalez, RG Hirsch, JA Lev, MH Schaefer, PW Schwamm, LH TI Causes of Ischemic Stroke SO ACUTE ISCHEMIC STROKE: IMAGING AND INTERVENTION, SECOND EDITION LA English DT Article; Book Chapter ID CERVICAL ARTERY DISSECTION; INTRACRANIAL ATHEROSCLEROTIC DISEASE; PATENT FORAMEN OVALE; RECURRENT CEREBROVASCULAR EVENTS; SYSTEMIC LUPUS-ERYTHEMATOSUS; HEALTH-CARE PROFESSIONALS; ATRIAL SEPTAL ANEURYSM; CENTRAL-NERVOUS-SYSTEM; OF-NEUROLOGY AFFIRMS; GIANT-CELL ARTERITIS C1 [Schwamm, Lee H.] Massachusetts Gen Hosp, Dept Neurol ACC 720, Boston, MA 02114 USA. [Koroshetz, Walter J.] NINDS, Off Director, NIH, Bethesda, MD 20892 USA. [Silva, Gisele S.] Univ Fed Sao Paulo, UNIFESP EPM, Sao Paulo, Brazil. RP Schwamm, LH (reprint author), Massachusetts Gen Hosp, Dept Neurol ACC 720, 55 Fruit St, Boston, MA 02114 USA. EM lscwamm@partners.org; lscwamm@partners.org OI Schwamm, Lee/0000-0003-0592-9145 NR 94 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY BN 978-3-642-12750-2 PY 2011 BP 25 EP 42 DI 10.1007/978-3-642-12751-9_2 PG 18 WC Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging; Peripheral Vascular Disease SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging; Cardiovascular System & Cardiology GA BSW03 UT WOS:000285942800002 ER PT B AU Rost, NS Koroshetz, WJ Gonzalez, RG Schwamm, LH AF Rost, Natalia S. Koroshetz, Walter J. Gonzalez, R. Gilberto Schwamm, Lee H. BE Gonzalez, RG Hirsch, JA Lev, MH Schaefer, PW Schwamm, LH TI Clinical Management of Acute Stroke SO ACUTE ISCHEMIC STROKE: IMAGING AND INTERVENTION, SECOND EDITION LA English DT Article; Book Chapter ID ACUTE ISCHEMIC-STROKE; AMERICAN-HEART-ASSOCIATION; ANTITHROMBOTIC THERAPY; THROMBOLYTIC THERAPY; GUIDELINES; STATEMENT; COUNCIL; RECOMMENDATIONS; SCALE; UNIT C1 [Gonzalez, R. Gilberto; Schwamm, Lee H.] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA. [Koroshetz, Walter J.] NINDS, NIH, Bethesda, MD 20892 USA. [Rost, Natalia S.] Massachusetts Gen Hosp, J Philip Kistler Stroke Res Ctr, Boston, MA 02114 USA. RP Schwamm, LH (reprint author), Massachusetts Gen Hosp, Dept Neurol, 55 Fruit St, Boston, MA 02114 USA. EM lscwamm@partners.org; lscwamm@partners.org OI Schwamm, Lee/0000-0003-0592-9145 NR 24 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY BN 978-3-642-12750-2 PY 2011 BP 211 EP 220 DI 10.1007/978-3-642-12751-9_10 PG 10 WC Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging; Peripheral Vascular Disease SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging; Cardiovascular System & Cardiology GA BSW03 UT WOS:000285942800010 ER PT B AU Brown, P Reaman, GH Seibel, NL Kearns, P AF Brown, Patrick Reaman, Gregory H. Seibel, Nita L. Kearns, Pamela BE Reaman, GH Smith, FO TI Promising Targeted Agents SO CHILDHOOD LEUKEMIA: A PRACTICAL HANDBOOK SE Pediatric Oncology LA English DT Article; Book Chapter ID ACUTE MYELOID-LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; INTERNAL TANDEM DUPLICATION; HISTONE DEACETYLASE INHIBITOR; ACUTE MYELOGENOUS LEUKEMIA; CHILDRENS ONCOLOGY GROUP; REFRACTORY HEMATOLOGIC MALIGNANCIES; DNA METHYLTRANSFERASE INHIBITORS; ACUTE PROMYELOCYTIC LEUKEMIA; PRECLINICAL TESTING PROGRAM C1 [Brown, Patrick] Sidney Kimmel Comprehens Canc Ctr, Dept Oncol, Baltimore, MD USA. [Brown, Patrick] Sidney Kimmel Comprehens Canc Ctr, Dept Pediat, Baltimore, MD USA. [Brown, Patrick] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Reaman, Gregory H.] George Washington Univ, Childrens Natl Med Ctr, Sch Med & Hlth Sci, Washington, DC 20010 USA. [Seibel, Nita L.] NCI, Canc Therapy Evaluat Program, Bethesda, MD 20892 USA. [Kearns, Pamela] Univ Birmingham, Sch Canc Sci, Birmingham, W Midlands, England. RP Brown, P (reprint author), Sidney Kimmel Comprehens Canc Ctr, Dept Oncol, Baltimore, MD USA. EM pbrown2@jhmi.edu; greaman@childrensoncologygroup.org NR 184 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY BN 978-3-642-13781-5 J9 PEDIATR ONCOL-BERLIN PY 2011 BP 193 EP 214 DI 10.1007/978-3-642-13781-5_7 D2 10.1007/978-3-642-13781-5 PG 22 WC Oncology; Pediatrics SC Oncology; Pediatrics GA BTG39 UT WOS:000286902800007 ER PT B AU Smith, M Devidas, M Wheatley, K Lock, RB Hunsberger, S AF Smith, Malcolm Devidas, Meenakshi Wheatley, Keith Lock, Richard B. Hunsberger, Sally BE Reaman, GH Smith, FO TI Strategies for New Agent Development and Clinical Trial Considerations SO CHILDHOOD LEUKEMIA: A PRACTICAL HANDBOOK SE Pediatric Oncology LA English DT Article; Book Chapter ID ACUTE LYMPHOBLASTIC-LEUKEMIA; PRECLINICAL TESTING PROGRAM; CHILDRENS ONCOLOGY GROUP; ACUTE MYELOID-LEUKEMIA; HUMAN TUMOR XENOGRAFTS; PHASE-I TRIALS; ACUTE PROMYELOCYTIC LEUKEMIA; ACUTE LYMPHOCYTIC-LEUKEMIA; REFRACTORY ACUTE-LEUKEMIA; B-CELL PRECURSOR C1 [Smith, Malcolm] NCI, Pediat Sect, CIB, CTEP, Bethesda, MD 20892 USA. [Devidas, Meenakshi] Childrens Oncol Grp, Ctr Data, Gainesville, FL 32601 USA. [Wheatley, Keith] Univ Birmingham, Canc Res UK Clin Trials Unit, Sch Canc Sci, Coll Med & Dent Sci, Birmingham B15 2TT, W Midlands, England. [Lock, Richard B.] Childrens Canc Inst Australia Med Res, Leukaemia Biol Program, Randwick, NSW 2031, Australia. [Hunsberger, Sally] NCI, Biometr Res Branch, Bethesda, MD 20892 USA. RP Smith, M (reprint author), NCI, Pediat Sect, CIB, CTEP, 6130 Execut Blvd,Execut Plaza N,Rm 7025, Bethesda, MD 20892 USA. EM malcolm.smith@nih.gov; mdevidas@cog.ufl.edu; k.wheatley@bham.ac.uk; richard.lock@unsw.edu.au; sallyh@ctep.nci.nih.gov RI Lock, Richard/G-4253-2013 NR 172 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY BN 978-3-642-13781-5 J9 PEDIATR ONCOL-BERLIN PY 2011 BP 215 EP 241 DI 10.1007/978-3-642-13781-5_8 D2 10.1007/978-3-642-13781-5 PG 27 WC Oncology; Pediatrics SC Oncology; Pediatrics GA BTG39 UT WOS:000286902800008 ER PT B AU Rader, C AF Rader, Christoph BE Medin, J Fowler, D TI Monoclonal Antibody Therapy for Cancer SO EXPERIMENTAL AND APPLIED IMMUNOTHERAPY LA English DT Article; Book Chapter DE Antibody engineering; Cancer; Hematologic malignancy; Solid malignancy; Therapeutic monoclonal antibodies ID METASTATIC COLORECTAL-CANCER; NON-HODGKINS-LYMPHOMA; GROWTH-FACTOR RECEPTOR; B-CELL LYMPHOMA; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; IBRITUMOMAB TIUXETAN RADIOIMMUNOTHERAPY; IMMUNOTOXIN RFB4(DSFV)-PE38 BL22; CHRONIC LYMPHOCYTIC-LEUKEMIA; BREAST-CANCER; FOLLICULAR LYMPHOMA AB Since the approval of rituximab (Rituxan (R)) for the treatment of B-cell non-Hodgkin's lymphoma (B-NHL) in 1997, nine additional monoclonal antibodies (mAbs) have been approved by the FDA for cancer therapy. Currently, more than 1,300 clinical studies registered at ClinicalTrials.gov investigate mAb therapy of cancer, including more than 150 phase III clinical trials. In concert with their clinical acceptance, mAbs in oncology have become commercially attractive. Four out of the ten approved mAbs have reached blockbuster status with annual sales exceeding $1 billion. The top three selling cancer drugs are all mAbs. These numbers indicate the potential of mAbs to play a leading role in cancer therapy for decades to come. Although mAbs provide a proven drug platform beyond the proof-of-concept stage, future success will depend on broadening and potentiating mAb therapy through antigen discovery, antibody engineering, use of mAbs in combination with chemotherapy and radiotherapy, and personalized medicine. C1 NCI, Antibody Technol Sect, Expt Transplantat & Immunol Branch, Ctr Canc Res,NIH, Bethesda, MD 20892 USA. RP Rader, C (reprint author), NCI, Antibody Technol Sect, Expt Transplantat & Immunol Branch, Ctr Canc Res,NIH, Bethesda, MD 20892 USA. EM raderc@mail.nih.gov NR 117 TC 1 Z9 1 U1 0 U2 1 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY BN 978-1-60761-979-6 PY 2011 BP 59 EP 83 DI 10.1007/978-1-60761-980-2_3 D2 10.1007/978-1-60761-980-2 PG 25 WC Oncology; Immunology; Medicine, Research & Experimental; Pathology SC Oncology; Immunology; Research & Experimental Medicine; Pathology GA BSY36 UT WOS:000286130400003 ER PT B AU McKay, MM Bell, CC Blake, CA AF McKay, Mary M. Bell, Carl C. Blake, Clair A. BE Pequegnat, W Stover, E Boyce, CA TI Community-Based Collaborations: Designing, Conducting and Sustaining Prevention Programs SO HOW TO WRITE A SUCCESSFUL RESEARCH GRANT APPLICATION: A GUIDE FOR SOCIAL AND BEHAVIORAL SCIENTISTS, SECOND EDITION LA English DT Article; Book Chapter ID MENTAL-HEALTH-SERVICES; RESEARCH PARTNERSHIPS; BASIC RESEARCH; PARTICIPATION; FAMILIES; CITIZEN; AIDS C1 [McKay, Mary M.] Mt Sinai Sch Med, Dept Psychiat & Preventat Med, New York, NY 10029 USA. [Bell, Carl C.] Univ Cent Lancashire, Fac Hlth, Inst Philosophy Divers & Mental Hlth, Ctr Ethn & Hlth, Preston PR1 2HE, Lancs, England. [Bell, Carl C.] NIMH, CHAMP Family Program, Bethesda, MD 20892 USA. [Blake, Clair A.] Mt Sinai Sch Med, Lab Dr Mary McKay, New York, NY USA. RP McKay, MM (reprint author), Mt Sinai Sch Med, Dept Psychiat & Preventat Med, New York, NY 10029 USA. EM mary.mckay@mssm.edu NR 39 TC 2 Z9 2 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4419-1453-8 PY 2011 BP 9 EP 20 DI 10.1007/978-1-4419-1454-5_2 D2 10.1007/978-1-4419-1454-5 PG 12 WC Social Sciences, Interdisciplinary SC Social Sciences - Other Topics GA BRQ12 UT WOS:000283396000002 ER PT B AU Lyman, W Stanton, B Pequegnat, W AF Lyman, William Stanton, Bonita Pequegnat, Willo BE Pequegnat, W Stover, E Boyce, CA TI Reading Between the Lines of Your Summary Statement SO HOW TO WRITE A SUCCESSFUL RESEARCH GRANT APPLICATION: A GUIDE FOR SOCIAL AND BEHAVIORAL SCIENTISTS, SECOND EDITION LA English DT Article; Book Chapter C1 [Lyman, William] Wayne State Univ, Sch Med, Carman & Ann Adams Dept Pediat, Detroit, MI 48202 USA. [Lyman, William] Childrens Hosp Michigan, Detroit Med Ctr, Detroit, MI 48201 USA. [Pequegnat, Willo] NIMH, Div AIDS, Bethesda, MD USA. RP Lyman, W (reprint author), Wayne State Univ, Sch Med, Carman & Ann Adams Dept Pediat, Detroit, MI 48202 USA. EM wlyman@med.wayne.edu NR 0 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4419-1453-8 PY 2011 BP 105 EP 113 DI 10.1007/978-1-4419-1454-5_9 D2 10.1007/978-1-4419-1454-5 PG 9 WC Social Sciences, Interdisciplinary SC Social Sciences - Other Topics GA BRQ12 UT WOS:000283396000009 ER PT B AU Szapocznik, J Pequegnat, W Prado, G AF Szapocznik, Jose Pequegnat, Willo Prado, Guillermo BE Pequegnat, W Stover, E Boyce, CA TI Designing an Intervention SO HOW TO WRITE A SUCCESSFUL RESEARCH GRANT APPLICATION: A GUIDE FOR SOCIAL AND BEHAVIORAL SCIENTISTS, SECOND EDITION LA English DT Article; Book Chapter ID RANDOMIZED CONTROLLED-TRIAL; HISPANIC ADOLESCENTS; FAMILY-THERAPY; SUBSTANCE USE; PREVENTION; EFFICACY; OUTCOMES C1 [Szapocznik, Jose] Univ Miami, Dept Epidemiol & Publ Hlth, Miami, FL 33136 USA. [Pequegnat, Willo] NIMH, Div AIDS, Bethesda, MD USA. RP Szapocznik, J (reprint author), Univ Miami, Dept Epidemiol & Publ Hlth, Miami, FL 33136 USA. EM Jszapocz@med.miami.edu NR 26 TC 2 Z9 2 U1 2 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4419-1453-8 PY 2011 BP 207 EP 227 DI 10.1007/978-1-4419-1454-5_17 D2 10.1007/978-1-4419-1454-5 PG 21 WC Social Sciences, Interdisciplinary SC Social Sciences - Other Topics GA BRQ12 UT WOS:000283396000017 ER PT B AU Kleiner, DE AF Kleiner, David E. BE Ferrell, LD Kakar, S TI Drug-Induced Liver Injury SO LIVER PATHOLOGY SE Consultant Pathology LA English DT Article; Book Chapter ID TOTAL PARENTERAL-NUTRITION; VANISHING BILE-DUCT; INDUCED INTRAHEPATIC CHOLESTASIS; CHRONIC ACTIVE HEPATITIS; LACTIC-ACIDOSIS; AMIODARONE HEPATOTOXICITY; INDUCED PHOSPHOLIPIDOSIS; HISTOPATHOLOGIC ANALYSIS; SCLEROSING CHOLANGITIS; AUTOIMMUNE HEPATITIS C1 NCI, Pathol Lab, NIH, Bethesda, MD 20892 USA. RP Kleiner, DE (reprint author), NCI, Pathol Lab, NIH, Bldg 10, Bethesda, MD 20892 USA. NR 89 TC 0 Z9 0 U1 0 U2 0 PU DEMOS MEDICAL PUBLICATIONS PI NEW YORK PA 11 WEST 42ND STREET, 15TH FLOOR, NEW YORK, NY 10036 USA BN 978-1-933864-93-8 J9 CONSULT PATHOL PY 2011 VL 4 BP 213 EP 242 PG 30 WC Gastroenterology & Hepatology; Pathology SC Gastroenterology & Hepatology; Pathology GA BUO60 UT WOS:000289931800015 ER PT B AU Moridani, MY Araujo, RP Johnson, CH Lindon, JC AF Moridani, Majid Y. Araujo, Robyn P. Johnson, Caroline H. Lindon, John C. BE Bonate, PL Howard, DR TI The -Omics in Drug Development SO PHARMACOKINETICS IN DRUG DEVELOPMENT, VOL 3: ADVANCES AND APPLICATIONS LA English DT Article; Book Chapter ID ABL TYROSINE KINASE; CHRONIC MYELOID-LEUKEMIA; DNA MICROARRAY DATA; BREAST-CANCER; PROTEIN MICROARRAYS; SIGNALING NETWORKS; H-1-NMR-BASED METABONOMICS; CLINICAL PROTEOMICS; MAGNETIC-RESONANCE; MASS-SPECTROMETRY AB New advancement in genomics, proteomics, and metabonomics created significant excitement about the use of these relatively new technologies in drug design, discovery, development, and molecular-targeted therapeutics by identifying new drug targets and better tools for safety and efficacy studies in preclinical and clinical stages of drug development as well as diagnostics. In this chapter, we will briefly discuss the application of genomics, proteomics, and metabonomics in drug discovery and development. C1 [Moridani, Majid Y.] Texas Tech Univ HSC, Dept Pharmaceut Sci, Sch Pharm, Amarillo, TX 79106 USA. [Moridani, Majid Y.] Texas Tech Univ HSC, Dept Pediat, Sch Med, Amarillo, TX 79106 USA. [Araujo, Robyn P.] George Mason Univ, Ctr Appl Prote & Mol Med, Manassas, VA USA. [Johnson, Caroline H.] NCI, Lab Metab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. [Lindon, John C.] Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Biomol Med, London, England. RP Moridani, MY (reprint author), Texas Tech Univ HSC, Dept Pharmaceut Sci, Sch Pharm, 1406 S Coulter Dr, Amarillo, TX 79106 USA. EM majid.moridani@ttuhsc.edu NR 79 TC 2 Z9 2 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4419-7936-0 PY 2011 BP 145 EP 173 DI 10.1007/978-1-4419-7937-7_7 D2 10.1007/978-1-4419-7937-7 PG 29 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA BTY16 UT WOS:000288417800007 ER PT B AU Doucleff, M Hatcher-Skeers, M Crane, NJ AF Doucleff, Michaeleen Hatcher-Skeers, Mary Crane, Nicole J. BA Doucleff, M HatcherSkeers, M Crane, NJ BF Doucleff, M HatcherSkeers, M Crane, NJ TI Atomic Bells and Frequency Finders SO POCKET GUIDE TO BIOMOLECULAR NMR LA English DT Article; Book Chapter C1 [Doucleff, Michaeleen] NIDDK, NIH, Bethesda, MD 20892 USA. [Crane, Nicole J.] USN, Henry M Jackson Fdn Adv Mil Med, Med Res Ctr, Dept Regenerat Med, Silver Spring, MD 20910 USA. [Hatcher-Skeers, Mary] Claremont Mckenna Coll, WM Keck Sci Ctr, Claremont, CA 91711 USA. RP Doucleff, M (reprint author), NIDDK, NIH, Bldg 5,Ctr Dr 31, Bethesda, MD 20892 USA. EM mcdoucleff@gmail.com; mhatcher@jsd.claremont.edu; Nicole.Crane@med.navy.mil; mcdoucleff@gmail.com; Nicole.Crane@med.navy.mil NR 4 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY BN 978-3-642-16250-3 PY 2011 BP 1 EP 18 DI 10.1007/978-3-642-16251-0_1 D2 10.1007/978-3-642-16251-0 PG 18 WC Biochemistry & Molecular Biology; Biology; Spectroscopy SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Spectroscopy GA BUN31 UT WOS:000289825200001 ER PT B AU Doucleff, M Hatcher-Skeers, M Crane, NJ AF Doucleff, Michaeleen Hatcher-Skeers, Mary Crane, Nicole J. BA Doucleff, M HatcherSkeers, M Crane, NJ BF Doucleff, M HatcherSkeers, M Crane, NJ TI Bonded Bells and Two-Dimensional Spectra SO POCKET GUIDE TO BIOMOLECULAR NMR LA English DT Article; Book Chapter C1 [Doucleff, Michaeleen] NIDDK, NIH, Bethesda, MD 20892 USA. [Crane, Nicole J.] USN, Henry M Jackson Fdn Adv Mil Med, Med Res Ctr, Dept Regenerat Med, Silver Spring, MD 20910 USA. [Hatcher-Skeers, Mary] Claremont Mckenna Coll, WM Keck Sci Ctr, Claremont, CA 91711 USA. RP Doucleff, M (reprint author), NIDDK, NIH, Bldg 5,Ctr Dr 31, Bethesda, MD 20892 USA. EM mcdoucleff@gmail.com; mhatcher@jsd.claremont.edu; Nicole.Crane@med.navy.mil; mcdoucleff@gmail.com; Nicole.Crane@med.navy.mil NR 4 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY BN 978-3-642-16250-3 PY 2011 BP 19 EP 42 DI 10.1007/978-3-642-16251-0_2 D2 10.1007/978-3-642-16251-0 PG 24 WC Biochemistry & Molecular Biology; Biology; Spectroscopy SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Spectroscopy GA BUN31 UT WOS:000289825200002 ER PT B AU Doucleff, M Hatcher-Skeers, M Crane, NJ AF Doucleff, Michaeleen Hatcher-Skeers, Mary Crane, Nicole J. BA Doucleff, M HatcherSkeers, M Crane, NJ BF Doucleff, M HatcherSkeers, M Crane, NJ TI Neighboring Bells and Structure Bundles SO POCKET GUIDE TO BIOMOLECULAR NMR LA English DT Article; Book Chapter C1 [Doucleff, Michaeleen] NIDDK, NIH, Bethesda, MD 20892 USA. [Crane, Nicole J.] USN, Henry M Jackson Fdn Adv Mil Med, Med Res Ctr, Dept Regenerat Med, Silver Spring, MD 20910 USA. [Hatcher-Skeers, Mary] Claremont Mckenna Coll, WM Keck Sci Ctr, Claremont, CA 91711 USA. RP Doucleff, M (reprint author), NIDDK, NIH, Bldg 5,Ctr Dr 31, Bethesda, MD 20892 USA. EM mcdoucleff@gmail.com; mhatcher@jsd.claremont.edu; Nicole.Crane@med.navy.mil; mcdoucleff@gmail.com; Nicole.Crane@med.navy.mil NR 7 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY BN 978-3-642-16250-3 PY 2011 BP 43 EP 73 DI 10.1007/978-3-642-16251-0_3 D2 10.1007/978-3-642-16251-0 PG 31 WC Biochemistry & Molecular Biology; Biology; Spectroscopy SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Spectroscopy GA BUN31 UT WOS:000289825200003 ER PT B AU Doucleff, M Hatcher-Skeers, M Crane, NJ AF Doucleff, Michaeleen Hatcher-Skeers, Mary Crane, Nicole J. BA Doucleff, M HatcherSkeers, M Crane, NJ BF Doucleff, M HatcherSkeers, M Crane, NJ TI Silencing of the Bells: Relaxation Theory Part One SO POCKET GUIDE TO BIOMOLECULAR NMR LA English DT Article; Book Chapter C1 [Doucleff, Michaeleen] NIDDK, NIH, Bethesda, MD 20892 USA. [Crane, Nicole J.] USN, Henry M Jackson Fdn Adv Mil Med, Med Res Ctr, Dept Regenerat Med, Silver Spring, MD 20910 USA. [Hatcher-Skeers, Mary] Claremont Mckenna Coll, WM Keck Sci Ctr, Claremont, CA 91711 USA. RP Doucleff, M (reprint author), NIDDK, NIH, Bldg 5,Ctr Dr 31, Bethesda, MD 20892 USA. EM mcdoucleff@gmail.com; mhatcher@jsd.claremont.edu; Nicole.Crane@med.navy.mil; mcdoucleff@gmail.com; Nicole.Crane@med.navy.mil NR 4 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY BN 978-3-642-16250-3 PY 2011 BP 75 EP 105 DI 10.1007/978-3-642-16251-0_4 D2 10.1007/978-3-642-16251-0 PG 31 WC Biochemistry & Molecular Biology; Biology; Spectroscopy SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Spectroscopy GA BUN31 UT WOS:000289825200004 ER PT B AU Doucleff, M Hatcher-Skeers, M Crane, NJ AF Doucleff, Michaeleen Hatcher-Skeers, Mary Crane, Nicole J. BA Doucleff, M HatcherSkeers, M Crane, NJ BF Doucleff, M HatcherSkeers, M Crane, NJ TI Relaxation Theory Part Two: Moving Atoms and Changing Notes SO POCKET GUIDE TO BIOMOLECULAR NMR LA English DT Article; Book Chapter C1 [Doucleff, Michaeleen] NIDDK, NIH, Bethesda, MD 20892 USA. [Crane, Nicole J.] USN, Henry M Jackson Fdn Adv Mil Med, Med Res Ctr, Dept Regenerat Med, Silver Spring, MD 20910 USA. [Hatcher-Skeers, Mary] Claremont Mckenna Coll, WM Keck Sci Ctr, Claremont, CA 91711 USA. RP Doucleff, M (reprint author), NIDDK, NIH, Bldg 5,Ctr Dr 31, Bethesda, MD 20892 USA. EM mcdoucleff@gmail.com; mhatcher@jsd.claremont.edu; Nicole.Crane@med.navy.mil; mcdoucleff@gmail.com; Nicole.Crane@med.navy.mil NR 3 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY BN 978-3-642-16250-3 PY 2011 BP 107 EP 129 DI 10.1007/978-3-642-16251-0_5 D2 10.1007/978-3-642-16251-0 PG 23 WC Biochemistry & Molecular Biology; Biology; Spectroscopy SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Spectroscopy GA BUN31 UT WOS:000289825200005 ER PT B AU Doucleff, M Hatcher-Skeers, M Crane, NJ AF Doucleff, Michaeleen Hatcher-Skeers, Mary Crane, Nicole J. BA Doucleff, M HatcherSkeers, M Crane, NJ BF Doucleff, M HatcherSkeers, M Crane, NJ TI Protein Dynamics SO POCKET GUIDE TO BIOMOLECULAR NMR LA English DT Article; Book Chapter ID MODEL-FREE APPROACH; NMR-SPECTROSCOPY; RELAXATION C1 [Doucleff, Michaeleen] NIDDK, NIH, Bethesda, MD 20892 USA. [Crane, Nicole J.] USN, Henry M Jackson Fdn Adv Mil Med, Med Res Ctr, Dept Regenerat Med, Silver Spring, MD 20910 USA. [Hatcher-Skeers, Mary] Claremont Mckenna Coll, WM Keck Sci Ctr, Claremont, CA 91711 USA. RP Doucleff, M (reprint author), NIDDK, NIH, Bldg 5,Ctr Dr 31, Bethesda, MD 20892 USA. EM mcdoucleff@gmail.com; mhatcher@jsd.claremont.edu; Nicole.Crane@med.navy.mil; mcdoucleff@gmail.com; Nicole.Crane@med.navy.mil NR 7 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY BN 978-3-642-16250-3 PY 2011 BP 131 EP 156 DI 10.1007/978-3-642-16251-0_6 D2 10.1007/978-3-642-16251-0 PG 26 WC Biochemistry & Molecular Biology; Biology; Spectroscopy SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Spectroscopy GA BUN31 UT WOS:000289825200006 ER PT J AU Qian, HH Ripps, H AF Qian, Haohua Ripps, Harris TI Neurovascular Interaction and the Pathophysiology of Diabetic Retinopathy SO EXPERIMENTAL DIABETES RESEARCH LA English DT Review ID ENDOTHELIAL GROWTH-FACTOR; PROTEIN-KINASE-C; RETINAL GANGLION-CELLS; NITRIC-OXIDE SYNTHASE; RECEPTOR RHO SUBUNITS; BLOOD-BRAIN-BARRIER; WHITE PERCH RETINA; GABA RECEPTOR; OXIDATIVE STRESS; BIPOLAR CELLS AB Diabetic retinopathy (DR) is the most severe of the several ocular complications of diabetes, and in the United States it is the leading cause of blindness among adults 20 to 74 years of age. Despite recent advances in our understanding of the pathogenesis of DR, there is a pressing need to develop novel therapeutic treatments that are both safe and efficacious. In the present paper, we identify a key mechanism involved in the development of the disease, namely, the interaction between neuronal and vascular activities. Numerous pathological conditions in the CNS have been linked to abnormalities in the relationship between these systems. We suggest that a similar situation arises in the diabetic retina, and we propose a logical strategy aimed at therapeutic intervention. C1 [Qian, Haohua; Ripps, Harris] Univ Illinois, Coll Med, Dept Ophthalmol & Visual Sci, Chicago, IL 60612 USA. [Qian, Haohua] NEI, Bethesda, MD 20892 USA. [Ripps, Harris] Univ Illinois, Coll Med, Dept Physiol & Biophys, Chicago, IL 60612 USA. [Ripps, Harris] Univ Illinois, Coll Med, Dept Anat & Cell Biol, Chicago, IL 60612 USA. [Ripps, Harris] Marine Biol Lab, Mol Physiol Program, Woods Hole, MA 02543 USA. RP Qian, HH (reprint author), Univ Illinois, Coll Med, Dept Ophthalmol & Visual Sci, 1855 W Taylor St, Chicago, IL 60612 USA. EM haohua.qian@nih.gov NR 125 TC 14 Z9 14 U1 1 U2 4 PU HINDAWI PUBLISHING CORPORATION PI NEW YORK PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA SN 1687-5214 EI 1687-5303 J9 EXP DIABETES RES JI Exp. Diabetes Res. PY 2011 AR 693426 DI 10.1155/2011/693426 PG 11 WC Endocrinology & Metabolism; Medicine, Research & Experimental SC Endocrinology & Metabolism; Research & Experimental Medicine GA 803FM UT WOS:000293567100001 ER PT J AU Rowzee, AM Cawley, NX Chiorini, JA Di Pasquale, G AF Rowzee, Anne M. Cawley, Niamh X. Chiorini, John A. Di Pasquale, Giovanni TI Glucagon-Like Peptide-1 Gene Therapy SO EXPERIMENTAL DIABETES RESEARCH LA English DT Review ID BETA-CELL PROLIFERATION; IN-VIVO EXPRESSION; INSULIN SENSITIVITY; MOUSE MODEL; PROGLUCAGON; PANCREAS; MICE; SECRETION; GLUCOSE; GLP-1 AB Glucagon-like peptide 1 (GLP-1) is a small peptide component of the prohormone, proglucagon, that is produced in the gut. Exendin-4, a GLP-1 receptor agonist originally isolated from the saliva of H. suspectum or Gila monster, is a peptide that shares sequence and functional homology with GLP-1. Both peptides have been demonstrated to stimulate insulin secretion, inhibit glucagon secretion, promote satiety and slow gastric emptying. As such, GLP-1 and Exendin-4 have become attractive pharmaceutical targets as an adjunctive therapy for individuals with type II diabetes mellitus, with several products currently available clinically. Herein we summarize the cell biology leading to GLP-1 production and secretion from intestinal L-cells and the endocrine functions of this peptide and Exendin-4 in humans. Additionally, gene therapeutic applications of GLP-1 and Exendin-4 are discussed with a focus on recent work using the salivary gland as a gene therapy target organ for the treatment of diabetes mellitus. C1 [Rowzee, Anne M.; Chiorini, John A.; Di Pasquale, Giovanni] Natl Inst Dent & Craniofacial Res, Mol Physiol & Therapeut Branch, Bethesda, MD 20892 USA. [Cawley, Niamh X.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Cellular Neurobiol Sect, Dept Hlth & Human Serv, NIH, Bethesda, MD 20892 USA. RP Di Pasquale, G (reprint author), Natl Inst Dent & Craniofacial Res, Mol Physiol & Therapeut Branch, Bethesda, MD 20892 USA. EM gd78i@nih.gov OI Rowzee, Anne/0000-0003-1969-9133 NR 55 TC 5 Z9 5 U1 0 U2 6 PU HINDAWI PUBLISHING CORPORATION PI NEW YORK PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA SN 1687-5214 J9 EXP DIABETES RES JI Exp. Diabetes Res. PY 2011 AR 601047 DI 10.1155/2011/601047 PG 5 WC Endocrinology & Metabolism; Medicine, Research & Experimental SC Endocrinology & Metabolism; Research & Experimental Medicine GA 803FF UT WOS:000293566400001 ER PT S AU Kozlowski, M Donohue, D Chen, M Daniels, M Connelly, P Jeffries, K Clevenger, R Wen, H Pai, VM AF Kozlowski, M. Donohue, D. Chen, M. Daniels, M. Connelly, P. Jeffries, K. Clevenger, R. Wen, H. Pai, V. M. BE Lin, CP Ntziachristos, V TI Coronary wall imaging in mice using osmium tetroxide and micro-computed tomography SO MOLECULAR IMAGING III SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Molecular Imaging III CY MAY 22-23, 2011 CL Munich, GERMANY SP SPIE, Opt Soc Amer DE Atherosclerosis; osmium tetroxide; microcomputed tomography; mouse ID DISEASE; ATHEROTHROMBOSIS AB Coronary artery disease (CAD) is a major cause of death in the United States and results from the accumulation of atherosclerotic plaques in the arteries of the heart. Plaques accumulate as the result of the retention of low-density lipoprotein (LDL) particles in the sub-endothelium of the arterial wall. In mouse aorta, these lesions form primarily at the branching sites or bifurcations. However, in the coronary system, data has shown that late-stage plaque formation occurs throughout the proximal segments of the arteries. In order to better understand plaque formation in the coronary arteries, we have developed an osmium tetroxide (OsO4) stained coronary wall imaging protocol performed using microcomputed tomography (microCT). OsO4 is a heavy metal contrast agent that readily binds to lipids. Our data in 3- to 25-week old C57BL6 wild-type mice shows that the coronary vessel walls are highlighted by the use of the contrast agent. We expect that this combination of OsO4 and microCT will allow us to investigate the coronary artery wall in atherogenesis models of mice to characterize plaque formation. C1 [Kozlowski, M.; Chen, M.; Wen, H.; Pai, V. M.] NHLBI, Lab Imaging Phys Biochem & Biophys Core, NIH, Bethesda, MD 20892 USA. RP Kozlowski, M (reprint author), NHLBI, Lab Imaging Phys Biochem & Biophys Core, NIH, Bldg 10, Bethesda, MD 20892 USA. RI Wen, Han/G-3081-2010 OI Wen, Han/0000-0001-6844-2997 NR 10 TC 0 Z9 0 U1 0 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-686-8 J9 PROC SPIE PY 2011 VL 8089 AR 80890P DI 10.1117/12.888991 PG 8 WC Optics; Imaging Science & Photographic Technology SC Optics; Imaging Science & Photographic Technology GA BWC12 UT WOS:000293397400011 ER PT J AU Liu, WM Meyer, J Scully, CG Elster, E Gorbach, AM AF Liu, Wei-Min Meyer, Joseph Scully, Christopher G. Elster, Eric Gorbach, Alexander M. TI Observing temperature fluctuations in humans using infrared imaging SO QIRT JOURNAL LA English DT Article DE thermoregulation; skin microvasculature; infrared imaging; low frequency oscillation; wavelet phase coherence ID OSCILLATIONS AB In this work we demonstrate that functional infrared imaging is capable of detecting low frequency temperature fluctuations in intact human skin and revealing spatial, temporal, spectral, and time-frequency based differences among three tissue classes: microvasculature, large sub-cutaneous veins, and the remaining surrounding tissue of the forearm. We found that large veins have stronger contractility in the range of 0.005-0.06 Hz compared to the other two tissue classes. Wavelet phase coherence and power spectrum correlation analysis show that micro vasculature and skin areas without vessels visible by IR have high phase coherence in the lowest three frequency ranges (0.005-0.0095 Hz, 0.0095-0.02 Hz, and 0.02-0.06 Hz), whereas large veins oscillate independently. C1 [Liu, Wei-Min; Elster, Eric] USN, Med Res Ctr, Silver Spring, MD USA. [Liu, Wei-Min; Meyer, Joseph; Scully, Christopher G.; Gorbach, Alexander M.] Natl Inst Biomed Imaging & Bioengn, NIH, Bethesda, MD USA. [Scully, Christopher G.] Worcester Polytech Inst, Worcester, MA 01609 USA. RP Liu, WM (reprint author), USN, Med Res Ctr, Silver Spring, MD USA. EM liuweim@mail.nih.gov; gorbach@helix.nih.gov FU National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health; Naval Medical Research Center; U.S. Navy Bureau of Medicine and Surgery, Office of Naval Research [602227D.0483.01.A0518 (MFEL)] FX This research was supported, in part, by the Intramural Research Program of the National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health and the Naval Medical Research Center.; The views expressed in this manuscript are those of the authors and do not reflect the official policy of the Department of the Army, Department of the Navy, the Department of Defense or the United States Government. This effort was supported (in part) by the U.S. Navy Bureau of Medicine and Surgery under the Medical Development Program and Office of Naval Research work unit number 602227D.0483.01.A0518 (MFEL). We are military service members (or other employees of the U.S. Government). This work was prepared as part of our official duties. Title 17 U.S.C. 105 provides the "Copyright protection under this title is not available for any work of the United States Government." Title 17 U.S.C. 101 defines a U.S. Government work as a work prepared by a military service member or employee of the U.S. Government as part of that person's official duties. NR 16 TC 4 Z9 4 U1 0 U2 0 PU LAVOISIER PI CACHAN PA 14, RUE DE PROVIGNY, 94236 CACHAN, FRANCE SN 1768-6733 J9 QIRT J JI QIRT J. PD JAN-JUN PY 2011 VL 8 IS 1 BP 21 EP 36 PG 16 WC Instruments & Instrumentation; Materials Science, Characterization & Testing; Physics, Applied SC Instruments & Instrumentation; Materials Science; Physics GA 796NN UT WOS:000293058100002 PM 23538682 ER PT B AU Akin, C Metcalfe, DD AF Akin, Cem Metcalfe, Dean D. BE Castells, MC TI Mastocytosis and Mast Cell Activation Syndromes Presenting as Anaphylaxis SO ANAPHYLAXIS AND HYPERSENSITIVITY REACTIONS LA English DT Article; Book Chapter DE Anaphylaxis; Mast cells; Mastocytosis; Mast cell activation disorders; C-kit ID SYSTEMIC MASTOCYTOSIS; IDIOPATHIC ANAPHYLAXIS; URTICARIA PIGMENTOSA; FATAL REACTIONS; BONE-MARROW; TRYPTASE; EXPRESSION; RECEPTOR; DIAGNOSIS; ALLERGY AB Anaphylaxis results from mast cell degranulation induced by allergen-specific IgE as well as various non-IgE-mediated mechanisms. It has been recently demonstrated that intrinsic abnormalities in mast cells, such as presence of activating D816V c-kit mutation, may influence susceptibility to anaphylaxis, especially in patients with "idiopathic" or hymenoptera-induced anaphylaxis. However, despite an improved understanding of the role of clonal mast cell disease in susceptibility to anaphylaxis, the basis of an apparent increase in susceptibility in the majority of patients remains poorly understood. In this chapter, we will review the potential mechanisms of mast cell activation as well as the range of symptoms and the differential diagnosis of patients suspected of having a disease caused by mast cell activation. In addition, we offer a global classification for disorders involving mast cells. C1 [Akin, Cem] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA. [Metcalfe, Dean D.] NIAID, NIH, Bethesda, MD 20892 USA. RP Akin, C (reprint author), Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA. EM dmetcalfe@niaid.nih.gov NR 46 TC 4 Z9 4 U1 0 U2 0 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA BN 978-1-60327-950-5 PY 2011 BP 245 EP 256 DI 10.1007/978-1-60327-951-2_15 D2 10.1007/978-1-60327-951-2 PG 12 WC Medicine, General & Internal SC General & Internal Medicine GA BSZ26 UT WOS:000286149900015 ER PT B AU Kim, P Evans, GW AF Kim, Pilyoung Evans, Gary W. BE Booth, A McHale, SM Landale, NS TI Family Resources, Genes, and Human Development SO BIOSOCIAL FOUNDATIONS OF FAMILY PROCESSES SE National Symposium on Family Issues LA English DT Proceedings Paper CT 17th Annual Penn State Symposium on Family Issues CY OCT 08-09, 2009 CL Penn State Univ, Univ Park Campus, PA SP Populat Res Inst, Children Youth & Families Consortium, Prevent Res Ctr, Women's Studies Program, Dept Social, Labor Studies & Employment Relat, Dept Human Dev & Family Studies, Dept Anthropology & Psychol, Natl Inst Child Hlth & Human Dev HO Penn State Univ ID METHYLTRANSFERASE VAL(158)MET GENOTYPE; TRANSPORTER GENE; ENVIRONMENT INTERACTION; NEURAL MECHANISMS; CHILDHOOD POVERTY; MATERNAL RESPONSIVENESS; GLUCOCORTICOID-RECEPTOR; CUMULATIVE RISK; ALLOSTATIC LOAD; DAILY HASSLES AB We review the effects of genes and family resources on families and children. Poverty increases children's exposures to environmental risk factors such as child abuse, poor quality parenting, and suboptimal physical environment. These environmental risk factors interact with various genes to predict more behavioral problems in childhood. Relations between genes and environments are likely more complex than simple individual gene x environment interactions. In some cases, genetic or environmental factors may have different impacts in low- vs. high-SES groups. Finally, we speculate about biological mechanisms that may account for gene by environment interactions. Poverty and related environmental factors may interact with genes, which may lead to abnormal brain development as well as dysregulation in both neurotransmitters and neuroendocrine stress regulatory systems. C1 [Kim, Pilyoung; Evans, Gary W.] NIMH, Emot & Dev Branch, Bethesda, MD 20892 USA. RP Kim, P (reprint author), NIMH, Emot & Dev Branch, Bethesda, MD 20892 USA. EM pilyoung.kim@nih.gov FU W.T.; John D. and Catherine T. MacArthur Foundation Network FX Preparation of this chapter was partially supported by the W.T. Grant Foundation, the John D. and Catherine T. MacArthur Foundation Network on Socioeconomic Status and Health. NR 46 TC 1 Z9 1 U1 5 U2 10 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4419-7360-3 J9 NATL SYMP FAM ISS PY 2011 BP 221 EP + DI 10.1007/978-1-4419-7361-0_15 PG 4 WC Family Studies SC Family Studies GA BVX83 UT WOS:000293099400015 ER PT J AU Zhou, HB You, JH Qin, GY Longnecker, MP AF Zhou, Haibo You, Jinhong Qin, Guoyou Longnecker, Matthew P. TI A partially linear regression model for data from an outcome-dependent sampling design SO JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES C-APPLIED STATISTICS LA English DT Article DE Estimated likelihood; Outcome-dependent sampling; Penalized spline; Semiparametric method ID EMPIRICAL LIKELIHOOD METHOD; COGNITIVE-DEVELOPMENT; CHILDREN; 2-PHASE; AGE; PENALTIES; RHYTHMS; SPLINES AB The outcome-dependent sampling scheme has been gaining attention in both the statistical literature and applied fields. Epidemiological and environmental researchers have been using it to select the observations for more powerful and cost-effective studies. Motivated by a study of the effect of in utero exposure to poly-chlorinated biphenyls on children's intelligence quotient at age 7 years, in which the effect of an important confounding variable is non-linear, we consider a semiparametric regression model for data from an outcome-dependent sampling scheme where the relationship between the response and covariates is only partially parameterized. We propose a penalized spline maximum likelihood estimation for inference on both the parametric and the non-parametric components and develop their asymptotic properties. Through simulation studies and an analysis of the intelligence study, we compare the proposed estimator with several competing estimators. Practical considerations of implementing those estimators are discussed. C1 [Zhou, Haibo] Univ N Carolina, Dept Biostat, Chapel Hill, NC 27599 USA. [Qin, Guoyou] Fudan Univ, Shanghai, Peoples R China. [Longnecker, Matthew P.] NIH, Res Triangle Pk, NC USA. RP Zhou, HB (reprint author), Univ N Carolina, Dept Biostat, Chapel Hill, NC 27599 USA. EM zhou@bios.unc.edu OI Longnecker, Matthew/0000-0001-6073-5322 FU National Institutes of Health [R01CA 79949]; National Institutes of Health, National Institute of Environmental Health Sciences; National Natural Science Foundation of China [10801039] FX This work is supported by a grant from the National Institutes of Health (R01CA 79949) (for Zhou, You and Qin) and in part by the intramural research programme of the National Institutes of Health, National Institute of Environmental Health Sciences (for Longnecker). Qin's work is also partially supported by the National Natural Science Foundation of China (10801039). NR 38 TC 3 Z9 3 U1 0 U2 10 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0035-9254 J9 J R STAT SOC C-APPL JI J. R. Stat. Soc. Ser. C-Appl. Stat. PY 2011 VL 60 BP 559 EP 574 DI 10.1111/j.1467-9876.2010.00756.x PN 4 PG 16 WC Statistics & Probability SC Mathematics GA 798TT UT WOS:000293235800005 PM 21966030 ER PT J AU Carpenter, J Moore, HM Juhl, H Thomas, G Miranda, LB AF Carpenter, Jane Moore, Helen M. Juhl, Hartmut Thomas, Geraldine Miranda, Lisa B. TI What Improvements Would You Recommend in the Collection of Control Samples? SO BIOPRESERVATION AND BIOBANKING LA English DT Editorial Material C1 [Carpenter, Jane] Univ Sydney, Westmead Millennium Inst, Australian Breast Canc Tissue Bank, Westmead, NSW 2145, Australia. [Moore, Helen M.] NCI, Biospecimen Res Network, Off Biorepositories & Biospecimen Res, Bethesda, MD 20892 USA. [Juhl, Hartmut] Indivumed GmbH, Inostics GmbH, D-20251 Hamburg, Germany. [Thomas, Geraldine] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, London W12 0HS, England. [Miranda, Lisa B.] Trans Hit Biomarkers Inc, Biobank Relat, Montreal, PQ H2V 1B7, Canada. [Miranda, Lisa B.] Bluechiip Ltd, Business Dev, Scoresby, Vic 3179, Australia. RP Carpenter, J (reprint author), Univ Sydney, Westmead Millennium Inst, Australian Breast Canc Tissue Bank, Westmead, NSW 2145, Australia. EM jane.carpenter@sydney.edu.au; moorehe@mail.nih.gov; juhl@indivumed.com; gerry.thomas@imperial.ac.uk; lisa.miranda.007@gmail.com NR 0 TC 1 Z9 1 U1 0 U2 2 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1947-5535 J9 BIOPRESERV BIOBANK JI Biopreserv. Biobank. PY 2011 VL 9 IS 2 SI SI BP 129 EP 131 DI 10.1089/bio.2011.9210 PG 3 WC Cell Biology; Chemistry, Applied; Medical Laboratory Technology SC Cell Biology; Chemistry; Medical Laboratory Technology GA 793FU UT WOS:000292806600001 PM 24846239 ER PT B AU Asthagiri, AR Kanter, AS Oldfield, EH Jane, JA AF Asthagiri, Ashok R. Kanter, Adam S. Oldfield, Edward H. Jane, John A., Jr. BE Mehta, MP Chang, SM Guha, A Newton, HB Vogelbaum, MA TI Transsphenoidal SO PRINCIPLES AND PRACTICE OF NEURO-ONCOLOGY: A MULTIDISCIPLINARY APPROACH LA English DT Article; Book Chapter ID SECRETING PITUITARY-ADENOMAS; HORMONE-RECEPTOR ANTAGONIST; TRANS-SPHENOIDAL REMOVAL; OF-THE-LITERATURE; FOLLOW-UP; STEREOTACTIC RADIOSURGERY; DIFFERENTIAL-DIAGNOSIS; CYTOTOXIC CHEMOTHERAPY; RADIATION-THERAPY; CUSHINGS-SYNDROME C1 [Asthagiri, Ashok R.] Natl Inst Neurol Disorders, Surg Neurol Branch, NIH, Bethesda, MD USA. [Kanter, Adam S.] Univ Pittsburgh, Med Ctr, Dept Neurosurg, Philadelphia, PA USA. [Oldfield, Edward H.] Univ Virginia Hlth Syst, Dept Neurosurg, Charlottesville, VA USA. [Jane, John A., Jr.] Univ Virginia, Dept Neurosurg, Charlottesville, VA USA. RP Asthagiri, AR (reprint author), Natl Inst Neurol Disorders, Surg Neurol Branch, NIH, Bethesda, MD USA. NR 74 TC 0 Z9 0 U1 0 U2 0 PU DEMOS MEDICAL PUBLICATIONS PI NEW YORK PA 11 WEST 42ND STREET, 15TH FLOOR, NEW YORK, NY 10036 USA BN 978-1-933864-78-5 PY 2011 BP 445 EP 452 PG 8 WC Oncology; Clinical Neurology SC Oncology; Neurosciences & Neurology GA BRX16 UT WOS:000283823500054 ER PT S AU Chambers, RA Lipska, BK AF Chambers, R. Andrew Lipska, Barbara K. BE ODonnell, P TI A Method to the Madness: Producing the Neonatal Ventral Hippocampal Lesion Rat Model of Schizophrenia SO ANIMAL MODELS OF SCHIZOPHRENIA AND RELATED DISORDERS SE Neuromethods LA English DT Article; Book Chapter DE Ventral hippocampus; neonatal lesions; ibotenic acid; neurodevelopmental; methods ID AMPHETAMINE; DAMAGE AB The neonatal ventral hippocampal lesion (NVHL) rat model of schizophrenia has demonstrated broad heuristic utility as an investigative platform encompassing many of the behavioral, neurobiological, and developmental aspects of this devastating neuropsychiatric illness affecting 1% of all human beings. This chapter serves as an essential description of materials and methods for generating and verifying the NVHL model in rats, which continues to hold significant potential in helping us understand schizophrenia, comorbid disorders, and their neurodevelopmental dynamics. Many of the approaches described here can be modified or adapted for producing other types of neurodevelopmental models of behavioral disorders. C1 [Chambers, R. Andrew] Indiana Univ Sch Med, Lab Translat Neurosci Dual Diag & Dev, Dept Psychiat, Indianapolis, IN USA. [Lipska, Barbara K.] NIMH, Clin Brain Disorders Branch, NIH, Bethesda, MD 20892 USA. RP Chambers, RA (reprint author), Indiana Univ Sch Med, Lab Translat Neurosci Dual Diag & Dev, Dept Psychiat, Indianapolis, IN USA. NR 9 TC 4 Z9 4 U1 0 U2 0 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA SN 0893-2336 BN 978-1-61779-156-7 J9 NEUROMETHODS JI Neuromethods PY 2011 VL 59 BP 1 EP 24 DI 10.1007/978-1-61779-157-4_1 PG 24 WC Cell Biology; Medicine, Research & Experimental; Neurosciences; Psychiatry; Psychology SC Cell Biology; Research & Experimental Medicine; Neurosciences & Neurology; Psychiatry; Psychology GA BVP49 UT WOS:000292220000001 ER PT S AU Belforte, JE Nakazawa, K AF Belforte, Juan E. Nakazawa, Kazu BE ODonnell, P TI Genetically Engineered Mice for Schizophrenia Research SO ANIMAL MODELS OF SCHIZOPHRENIA AND RELATED DISORDERS SE Neuromethods LA English DT Article; Book Chapter DE NMDA receptor; GABAergic neurons; conditional knockout; schizophrenia; animal model; ketamine; MK-801; NMDAR hypomorph; Cre/IoxP ID NMDA RECEPTOR HYPOFUNCTION; TARGETED POINT MUTATIONS; GLYCINE BINDING-SITE; PREFRONTAL CORTEX; ANIMAL-MODELS; GLUTAMATERGIC NEUROTRANSMISSION; PREPULSE INHIBITION; KETAMINE; PHENCYCLIDINE; PSYCHOSIS AB NMDA receptor (NMDAR) hypofunction theory of schizophrenia has been assessed in rodents with pharmacological intervention and global knockout strategy of NMDAR blockade. However, these manipulations of NMDAR function have been relatively coarse, affecting all NMDA receptors throughout the brain. Here we tested the effects of eliminating NMDA receptors in about half the interneurons located in the cortex and the hippocampus in early postnatal development by engineering "conditional knockout" mice. Remarkably, the mutant mice produced a variety of schizophrenia-related phenotypes. C1 [Belforte, Juan E.] Univ Buenos Aires, Dept Fisiol, Buenos Aires, DF, Argentina. [Nakazawa, Kazu] NIMH, Unit Genet Cognit & Behav, NIH, Bethesda, MD 20892 USA. RP Belforte, JE (reprint author), Univ Buenos Aires, Dept Fisiol, Buenos Aires, DF, Argentina. RI Nakazawa, Kazutoshi/J-6195-2015 OI Nakazawa, Kazutoshi/0000-0001-5699-9093 NR 51 TC 1 Z9 1 U1 0 U2 0 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA SN 0893-2336 BN 978-1-61779-156-7 J9 NEUROMETHODS JI Neuromethods PY 2011 VL 59 BP 231 EP 242 DI 10.1007/978-1-61779-157-4_10 PG 12 WC Cell Biology; Medicine, Research & Experimental; Neurosciences; Psychiatry; Psychology SC Cell Biology; Research & Experimental Medicine; Neurosciences & Neurology; Psychiatry; Psychology GA BVP49 UT WOS:000292220000010 ER PT B AU Panchision, DM AF Panchision, David M. BE Phinney, DG TI Molecular Mechanisms Regulating Adult Stem Cell Self-Renewal SO ADULT STEM CELLS: BIOLOGY AND METHODS OF ANALYSIS SE Stem Cell Biology and Regenerative Medicine LA English DT Article; Book Chapter DE Neural stem cell; Intermediate progenitor cell/Transit amplifying cell; Neuroblast; Self-renewal; Multipotency; Clonal analysis; Cell cycle; Mitogen; Morphogen; Symmetric division; Asymmetric division; Lateral inhibition; Selection; Instruction; Neurogenesis ID EPIDERMAL-GROWTH-FACTOR; SUBVENTRICULAR ZONE ASTROCYTES; SUBCORTICAL WHITE-MATTER; NEURAL PROGENITOR CELLS; NERVOUS-SYSTEM; HIPPOCAMPAL NEUROGENESIS; VASCULAR NICHE; INTERMEDIATE PROGENITORS; TRANSCRIPTION FACTORS; SUBEPENDYMAL ZONE AB Stem cells have defining properties that are suited for tissue homeostasis and repair, but a central issue is how these cells generate mature cell types without exhausting their capacity for self-renewal. This chapter focuses on the central nervous system (CNS) to exemplify the regulation of adult stem cell self-renewal in the service of organ function. Topics will include conventional and novel methods used to distinguish stem cells from other proliferating cell types and the pitfalls in attempting to precisely characterize stem cell function. These methods reveal that stem cells interpret multiple signals to control the balance of self-renewal and quiescence. Among the emerging themes is that stem cell self-renewal is dynamically regulated throughout life, is integrally connected with lineage specification, and reflects a conservation of many intrinsic and extrinsic mechanisms from fetal development. C1 NIMH, Div Neurosci & Basic Behav Sci, NIH, Bethesda, MD 20892 USA. RP Panchision, DM (reprint author), NIMH, Div Neurosci & Basic Behav Sci, NIH, Bethesda, MD 20892 USA. EM panchisiond@mail.nih.gov NR 118 TC 1 Z9 1 U1 0 U2 4 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA BN 978-1-61779-001-0 J9 STEM CELLS BIOL REG JI Stem Cell Biol. Regen. Med. PY 2011 BP 3 EP 33 DI 10.1007/978-1-61779-002-7_1 D2 10.1007/978-1-61779-002-7 PG 31 WC Cell & Tissue Engineering; Developmental Biology SC Cell Biology; Developmental Biology GA BTU50 UT WOS:000288113800001 ER PT B AU Mezey, E AF Mezey, Eva BE Phinney, DG TI Adult Stem Cell Plasticity Revisited SO ADULT STEM CELLS: BIOLOGY AND METHODS OF ANALYSIS SE Stem Cell Biology and Regenerative Medicine LA English DT Article; Book Chapter DE Adult stem cells; Bone marrow-derived stem cells; Chimerism; Neurogenesis; Tissue-specific stem cells; Transdifferentiation ID BONE-MARROW-CELLS; CENTRAL-NERVOUS-SYSTEM; VERSUS-HOST-DISEASE; EPITHELIAL-CELLS; IN-VIVO; MUSCLE REGENERATION; CANCER-THERAPIES; SKELETAL-MUSCLE; STROMAL CELLS; NEUROLOGICAL DISEASES AB Cell biologists have long realized that most cells do not live as long as the organisms they comprise; thus, cells in almost every tissue need to be renewed/replaced during the natural lifespan of the organism. Depending on the turnover rate of cells in any given organ, this process can be very frequent or very rare. Epithelial cells in the mouth and the GI tract are exposed to a variety of insults (such as heat, cold, extreme changes in pH, strong spices, etc.) and have a very fast turnover rate; nerve cells get wired during embryonal development and either do not turn over or have a very low turnover rate. The rest of the tissues are somewhere in between. This kind of tissue regeneration relies on undifferentiated tissue-specific stem cells (also known as somatic stem cells) that are found in all adult animals and humans and multiply by cell division. They replenish cells that die from old age and regenerate those that have been damaged. Scientific interest in adult stem cells has centered on their ability to divide or self-renew indefinitely and generate all the cell types of the organ from which they originate, potentially regenerating the entire organ from a few cells. Unlike embryonic stern cells, the use of adult stem cells in research and therapy is not considered to be controversial as they are derived from adult tissue samples rather than human embryos. They have mainly been studied in humans and model organisms such as mice and rats. Adult stem cells can potentially be used (1) to help us understand basic biological mechanisms (2) to regenerate aged or damaged tissues, and (3) to improve the health of organs by releasing agents that promote growth or differentiation of cells. Below, I will try to summarize the present knowledge of adult stem cells with regard to their (trans)differentiation abilities. Due to the vast amount of literature available, I will focus on human data when they are available and refer the reader to reviews for more details than I can provide in the space available. C1 Natl Inst Dent & Craniofacial Res, NIH, Bethesda, MD 20892 USA. RP Mezey, E (reprint author), Natl Inst Dent & Craniofacial Res, NIH, Bldg 49,5A76 49 Convent Dr, Bethesda, MD 20892 USA. EM mezeye@mail.nih.gov NR 120 TC 1 Z9 1 U1 1 U2 6 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA BN 978-1-61779-001-0 J9 STEM CELLS BIOL REG JI Stem Cell Biol. Regen. Med. PY 2011 BP 113 EP 131 DI 10.1007/978-1-61779-002-7_5 D2 10.1007/978-1-61779-002-7 PG 19 WC Cell & Tissue Engineering; Developmental Biology SC Cell Biology; Developmental Biology GA BTU50 UT WOS:000288113800005 ER PT S AU Bhangoo, SK Petty, L White, FA AF Bhangoo, Sonia K. Petty, Lauren White, Fletcher A. BE Ma, C Zhang, JM TI Animal Models of HIV-Associated Painful Sensory Neuropathy SO ANIMAL MODELS OF PAIN SE Neuromethods LA English DT Article; Book Chapter ID ENVELOPE GLYCOPROTEIN GP120; PERIPHERAL NEUROPATHY; HYPERSENSITIVITY; FACILITATION; INVOLVEMENT; NEURONS; STATES; DRUGS; RAT AB Painful distal sensory neuropathy is the most common neurological complication of HIV1 infection. There are several neuropathic pain syndromes associated with the disease; however, the most common is a sensory neuropathy called HIV sensory neuropathy (HIV-SN). HIV-SN can be subdivided into subacute or chronic distal sensory polyneuropathy (DSP) and subacute antiretroviral-induced toxic neuropathy (ATN). Both forms involve sensory loss and neuropathic pain. DSP occurs in up to 7-35% of HIV1-infected individuals and upwards of 34% of children infected with HIV1, while ATN develops following highly active antiretroviral therapy (HAART) treatment in up to 52% of patients. The mechanisms of HIV-SN remain unclear; however, the advent of several models of HIV1-associated peripheral neuropathy is helping unlock the mysteries surrounding HIV-SN. This chapter describes the known pathology of HIV1 and the resulting neuropathy syndromes, including descriptions of the models used to study this particular type of neuropathic pain. C1 [Bhangoo, Sonia K.] Natl Inst Dent & Craniofacial Res, Lab Sensory Biol, NIH, Bethesda, MD USA. [Petty, Lauren; White, Fletcher A.] Indiana Univ, Sch Med, Dept Anesthesia, Stark Neurosci Res Inst, Indianapolis, IN 46202 USA. RP Bhangoo, SK (reprint author), Natl Inst Dent & Craniofacial Res, Lab Sensory Biol, NIH, Bethesda, MD USA. RI White, Fletcher/F-3203-2015 OI White, Fletcher/0000-0002-8408-9262 NR 29 TC 0 Z9 0 U1 0 U2 0 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA SN 0893-2336 BN 978-1-60761-879-9 J9 NEUROMETHODS JI Neuromethods PY 2011 VL 49 BP 171 EP 179 DI 10.1007/978-1-60761-880-5_10 D2 10.1007/978-1-60761-880-5 PG 9 WC Cell Biology; Neurosciences SC Cell Biology; Neurosciences & Neurology GA BRN76 UT WOS:000283201100010 ER PT B AU Gottesman, S AF Gottesman, Susan BE Storz, G Hengge, R TI Roles of mRNA Stability, Translational Regulation, and Small RNAs in Stress Response Regulation SO BACTERIAL STRESS RESPONSES, 2ND EDITION LA English DT Article; Book Chapter ID SMALL NONCODING RNAS; PSEUDOMONAS-FLUORESCENS CHA0; STAPHYLOCOCCUS-AUREUS RNAIII; OUTER-MEMBRANE PROTEINS; ESCHERICHIA-COLI HFQ; BACTERIAL SMALL RNA; GENE-EXPRESSION; DSRA RNA; DEPENDENT REGULATION; ANTISENSE MECHANISM AB Bacteria use every possible level of regulation for rapid response to stress and rapid readjustment after adaptation. The important roles that regulation of mRNA stability and translation play have only been fully recognized in the past 15 years. Regulatory mechanisms such as attenuation have been known for many years to affect mRNA folding, leading to changes in transcription termination under specific conditions; now small molecule effectors have been found to also lead to changes in folding of 5' untranslated regions (UTRs), affecting termination and translation (riboswitches). In Escherichia. coli, a variety of small regulatory RNAs have been found the majority of these regulate at the level of the mRNA. In many cases, the synthesis of these sRNAs is regulated as part of well-known global regulons. The largest class of sRNAs regulate mRNA stability and translation by pairing with specific target mRNAs. Efficient pairing requires the RNA chaperone Hfq. Other regulatory RNAs act to modulate the activity of translational regulators. Yet others do not yet have defined activities. Approaches used to define sRNAs and their function in E. coli and Salmonella are being applied broadly to other microorganisms. The general conclusion is that many, and possibly all, stress responses will be regulated at the level of mRNA stability and activity, as well as at other levels. C1 NCI, Mol Biol Lab, Bethesda, MD 20892 USA. RP Gottesman, S (reprint author), NCI, Mol Biol Lab, Bldg 37, Bethesda, MD 20892 USA. NR 113 TC 2 Z9 2 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA BN 978-1-55581-621-6 PY 2011 BP 59 EP 73 PG 15 WC Microbiology SC Microbiology GA BSJ67 UT WOS:000284726100005 ER PT B AU Makarova, KS Daly, MJ AF Makarova, Kira S. Daly, Michael J. BE Storz, G Hengge, R TI Comparative Genomics of Stress Response Systems in Deinococcus Bacteria SO BACTERIAL STRESS RESPONSES, 2ND EDITION LA English DT Article; Book Chapter ID DOUBLE-STRAND BREAKS; ESCHERICHIA-COLI; IONIZING-RADIATION; EXTREME RADIORESISTANCE; GAMMA-RADIATION; RADIODURANS R1; DNA-POLYMERASE; HYDROGEN-PEROXIDE; RESISTANT MUTANTS; SP-NOV. AB Bacteria of the genus Deinococcus represent life's outer limits for the bounds of radiation and desiccation resistance. Using a comparative genomic approach, we investigated the genetic determinants of these extremophilic traits in Deinococcus radiodurans, Deinococcus geothermalis, and Deinococcus deserti. Within this group, common evolutionary trends and a putative radiation response regulon were identified. Viewed from this perspective, contemporary hypotheses of extreme resistance are evaluated in this chapter : Arguments are presented that support that the Deinococcus lineage emerged progressively by amassing enzymatic and nonenzymatic cell-cleaning systems, but not by acquisition of novel DNA repair systems. C1 [Makarova, Kira S.] Natl Lib Med, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA. [Daly, Michael J.] Uniformed Serv Univ Hlth Sci, Dept Pathol, Bethesda, MD 20814 USA. RP Makarova, KS (reprint author), Natl Lib Med, Natl Ctr Biotechnol Informat, NIH, 8600 Rockville Pike, Bethesda, MD 20894 USA. NR 93 TC 1 Z9 1 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA BN 978-1-55581-621-6 PY 2011 BP 445 EP 457 PG 13 WC Microbiology SC Microbiology GA BSJ67 UT WOS:000284726100027 ER PT S AU Chen, GA Henter, ID Manji, HK AF Chen, Guang Henter, Ioline D. Manji, Husseini K. BE Manji, HK Zarate, CA TI Partial Rodent Genetic Models for Bipolar Disorder SO BEHAVIORAL NEUROBIOLOGY OF BIPOLAR DISORDER AND ITS TREATMENT SE Current Topics in Behavioral Neurosciences LA English DT Article; Book Chapter DE Bipolar disorder; Mania; Depression; Antidepressants; Mood stabilizers; p11; Vesicular monoamine transporter 2 (VMAT2); Neural cell adhesion molecule (NCAM); Extracellular signal-regulated kinase (ERK); Glutamate receptor 6 (GluR6); Glucocorticoid receptor (GR); B-cell lymphoma 2 (Bcl-2); Bcl-2 associated athanogene (BAG1) ID ANIMAL-MODELS; GLUCOCORTICOID-RECEPTOR; MOOD DISORDERS; MICE LACKING; MUTANT MICE; BEHAVIORAL SENSITIZATION; ANTIDEPRESSANT TREATMENT; MAP KINASE; CLOCK GENE; DEPRESSION AB Bipolar disorder (BPD) is a complex clinical phenomenon This episodic illness comprises at least four features/components depression, mania vulnerability to mood swings in euthymic BPD patients, and spontaneous cyclicity in at least some BPD patients Currently, there is no rodent genetic model capable of encompassing the whole phenotype of BPD exists, however, recent genetic-behavioral studies have delineated partial models for some components of BPD, namely, depression, mania, and vulnerability or resilience to mood swings p11 knockout (KO), vesicular monoamine transporter 2 (VMAT2) heterozygous KO, and neural cell adhesion molecule (NCAM) KO mice display anhedonia-like symptoms, and treatment with antidepressants rescues this anhedonia-related phenotype Mutant CLOCK, glutamate receptor 6 (GluR6) KO, and extracellular signal-regulated kinase 1 (ERK1) KO mice exhibit mania-like behavioral clusters referred to as excessive behavioral excitement, at least some of the exhibited behaviors can be rescued through treatment with mood stabilizers or atypical antipsychotics Neuronal glucocorticoid receptor (GR) overexpressing, B-cell lymphoma 2 (Bcl-2) heterozygous KO, and Bcl-2-associated athanogene (BAG1) heterozygous KO mice show vulnerability to mood swings In contrast, neuronal BAG1 overexpressing mice display resilience to mood swings These mutant mouse strains and the behavioral approaches used to characterize these strains offer an emerging set of research tools for the comprehensive understanding of various components of BPD, and the interrelation of these components at the molecular, cellular, and neuronal circuitry levels These partial genetic models can also be used as complementary tools to augment other existing behavioral tests and paradigms in drug development for BPD C1 [Chen, Guang; Henter, Ioline D.] NIMH, Mood & Anxiety Disorders Program, Intramural Res Program, NIH, Bethesda, MD 20892 USA. [Manji, Husseini K.] Johnson & Johnson Pharmaceut Res & Dev, Titusville, NJ USA. RP Chen, GA (reprint author), NIMH, Mood & Anxiety Disorders Program, Intramural Res Program, NIH, Bldg 35 Rm 1C912 35 Convent Dr, Bethesda, MD 20892 USA. RI Chen, Guang/A-2570-2017 FU Intramural NIH HHS [Z99 MH999999] NR 71 TC 3 Z9 3 U1 0 U2 1 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 1866-3370 BN 978-3-642-15756-1 J9 CURR TOP BEHAV NEURO JI Cur. Top. Behav. Neurosci. PY 2011 VL 5 BP 89 EP 106 DI 10.1007/7854_2010_63 D2 10.1007/978-3-642-15757-8 PG 18 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA BSM87 UT WOS:000284977600006 PM 25236551 ER PT S AU Du, J Machado-Vieira, R Khairova, R AF Du, Jing Machado-Vieira, Rodrigo Khairova, Rushaniya BE Manji, HK Zarate, CA TI Synaptic Plasticity in the Pathophysiology and Treatment of Bipolar Disorder SO BEHAVIORAL NEUROBIOLOGY OF BIPOLAR DISORDER AND ITS TREATMENT SE Current Topics in Behavioral Neurosciences LA English DT Article; Book Chapter DE BDNF; Bipolar disorder; Cytokine; Mood stabilizer; Stress; Synaptic plasticity ID LONG-TERM POTENTIATION; AMPA-RECEPTOR TRAFFICKING; RAT HIPPOCAMPAL SLICES; SUBGENUAL PREFRONTAL CORTEX; MAJOR DEPRESSIVE DISORDER; NECROSIS-FACTOR-ALPHA; FORCED SWIM TEST; GLIAL TNF-ALPHA; DENTATE GYRUS; MOOD DISORDERS AB Emerging evidence suggests that synaptic plasticity is intimately involved in the pathophysiology and treatment of bipolar disorder (BPD) Under certain conditions, over-strengthened and/or weakened synapses at different circuits in the brain could disturb brain functions in parallel, causing manic-like or depressive-like behaviors in animal models In this chapter, we summarize the regulation of synaptic plasticity by medications, psychological conditions, hormones, and neurotrophic factors, and their correlation with mood-associated animal behaviors We conclude that increased serotonin, norepinephrine, dopamine, brain-derived neurotrophic factor (BDNF), acute corticosterone, and antidepressant treatments lead to enhanced synaptic strength in the hippocampus and also correlate with antidepressant-like behaviors In contrast, inhibiting monoaminergic signaling, long-term stress, and pathophysiological concentrations of cytokines weakens glutamatergic synaptic strength in the hippocampus and is associated with depressive-like symptoms C1 [Du, Jing; Machado-Vieira, Rodrigo; Khairova, Rushaniya] NIMH, Mol Pathophysiol Lab, Mood & Anxiety Disorders Program, NIH, Bethesda, MD 20892 USA. [Machado-Vieira, Rodrigo] NIMH, Expt Therapeut Mood & Anxiety Disorders Res Progr, NIH, Mark O Hatfield CRC, Bethesda, MD 20892 USA. [Machado-Vieira, Rodrigo] Univ Sao Paulo, LIM Inst Psychiat, Sao Paulo, Brazil. RP Du, J (reprint author), NIMH, Mol Pathophysiol Lab, Mood & Anxiety Disorders Program, NIH, 9000 Rockville Pike Bldg 35 1BC909, Bethesda, MD 20892 USA. RI MACHADO-VIEIRA, RODRIGO/D-8293-2012 OI MACHADO-VIEIRA, RODRIGO/0000-0002-4830-1190 NR 147 TC 2 Z9 2 U1 2 U2 7 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 1866-3370 BN 978-3-642-15756-1 J9 CURR TOP BEHAV NEURO JI Cur. Top. Behav. Neurosci. PY 2011 VL 5 BP 167 EP 185 DI 10.1007/7854_2010_65 D2 10.1007/978-3-642-15757-8 PG 19 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA BSM87 UT WOS:000284977600010 PM 25236555 ER PT S AU Machado-Vieira, R Manji, HK Zarate, CA AF Machado-Vieira, Rodrigo Manji, Husseini K. Zarate, Carlos A., Jr. BE Manji, HK Zarate, CA TI Potential Novel Therapeutics for Bipolar Disorders SO BEHAVIORAL NEUROBIOLOGY OF BIPOLAR DISORDER AND ITS TREATMENT SE Current Topics in Behavioral Neurosciences LA English DT Article; Book Chapter DE Bipolar disorder; Depression; Mania; Targets; Treatment ID PROTEIN-KINASE-C; MAJOR DEPRESSIVE DISORDER; PLACEBO-CONTROLLED TRIAL; FORCED SWIMMING TEST; AGOMELATINE ADJUNCTIVE THERAPY; LEARNED HELPLESSNESS PARADIGM; GLYCOGEN-SYNTHASE KINASE-3; OPIOID-RECEPTOR-AGONIST; OPEN-LABEL TRIAL; MOOD DISORDERS AB Existing pharmacological treatments for bipolar disorder (BPD), a severe recurrent mood disorder, are in general insufficient for many patients Despite adequate doses and treatment duration many individuals with this disease continue to experience mood episode relapses, residual symptoms, and functional impairment This chapter reviews a number of targets/compounds that could result in putative novel treatments for BPD, including the dynorphin opioid neuropeptide system, the glutamatergic system, the purinergic system, the cholinergic system (muscarinic and nicotinic systems), the oxidative stress system, and the melatonergic system The arachidonic acid cascade and intracellular signaling cascades (including glycogen synthase kinase 3 and protein kinase C) are also reviewed, as are agents that affect multiple targets (e g, modafinil, Undine RG2417) Further study of these and similar agents may improve our understanding of relevant drug targets and their clinical utility as potential therapeutics for this devastating disorder C1 [Zarate, Carlos A., Jr.] NIMH, Expt Therapeut & Pathophysiol Branch, Intramural Res Program, NIH,Mark O Hatfield Clin Res Ctr, Bethesda, MD 20892 USA. [Machado-Vieira, Rodrigo] NIMH, Expt Therapeut Mood & Anxiety Disorders Res Progr, NIH, Mark O Hatfield CRC, Bethesda, MD 20892 USA. [Machado-Vieira, Rodrigo] Univ Sao Paulo, LIM Inst Psychiat, BR-05508 Sao Paulo, Brazil. [Manji, Husseini K.] Johnson & Johnson Pharmaceut Res & Dev, Titusville, NJ USA. [Machado-Vieira, Rodrigo] NIMH, Mol Pathophysiol Lab, Mood & Anxiety Disorders Program, NIH, Bethesda, MD 20892 USA. RP Zarate, CA (reprint author), NIMH, Expt Therapeut & Pathophysiol Branch, Intramural Res Program, NIH,Mark O Hatfield Clin Res Ctr, 10 Ctr Dr,Unit 7 SE,Rm 7 3465, Bethesda, MD 20892 USA. RI MACHADO-VIEIRA, RODRIGO/D-8293-2012 OI MACHADO-VIEIRA, RODRIGO/0000-0002-4830-1190 NR 178 TC 0 Z9 0 U1 2 U2 3 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 1866-3370 BN 978-3-642-15756-1 J9 CURR TOP BEHAV NEURO JI Cur. Top. Behav. Neurosci. PY 2011 VL 5 BP 303 EP 329 DI 10.1007/7854_2010_51 D2 10.1007/978-3-642-15757-8 PG 27 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA BSM87 UT WOS:000284977600017 PM 25236562 ER PT S AU Manji, HK Henter, ID Zarate, CA AF Manji, Husseini K. Henter, Ioline D. Zarate, Carlos A., Jr. BE Manji, HK Zarate, CA TI Bipolar Disorder: A Neurobiological Synthesis SO BEHAVIORAL NEUROBIOLOGY OF BIPOLAR DISORDER AND ITS TREATMENT SE Current Topics in Behavioral Neurosciences LA English DT Article; Book Chapter ID SCHIZOPHRENIA; PLASTICITY; PATHWAYS C1 [Zarate, Carlos A., Jr.] NIMH, Expt Therapeut & Pathophysiol Branch, Intramural Res Program, NIH,Mark O Hatfield Clin Res Ctr, Bethesda, MD 20892 USA. [Manji, Husseini K.] Johnson & Johnson Pharmaceut Res & Dev, Titusville, NJ USA. [Henter, Ioline D.] NIMH, Mood & Anxiety Disorders Program, Intramural Res Program, NIH, Bethesda, MD 20892 USA. RP Zarate, CA (reprint author), NIMH, Expt Therapeut & Pathophysiol Branch, Intramural Res Program, NIH,Mark O Hatfield Clin Res Ctr, 10 Ctr Dr Unit 7 SE Rm 7 3465, Bethesda, MD 20892 USA. FU Intramural NIH HHS [Z99 MH999999] NR 18 TC 1 Z9 1 U1 1 U2 2 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 1866-3370 BN 978-3-642-15756-1 J9 CURR TOP BEHAV NEURO JI Cur. Top. Behav. Neurosci. PY 2011 VL 5 BP 331 EP 340 DI 10.1007/7854_2010_98 D2 10.1007/978-3-642-15757-8 PG 10 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA BSM87 UT WOS:000284977600018 PM 25236563 ER PT B AU Palmer, RJ Darveau, R Lamont, RJ Nyvad, B Teles, RP AF Palmer, Robert J., Jr. Darveau, Richard Lamont, Richard J. Nyvad, Bente Teles, Ricardo P. BE Bjarnsholt, T Moser, C Jensen, PO Hoiby, N TI Human Oral Bacterial Biofilms: Composition, Dynamics, and Pathogenesis SO BIOFILM INFECTIONS LA English DT Article; Book Chapter ID HUMAN PERIODONTAL POCKETS; LIPOPOLYSACCHARIDE-BINDING PROTEIN; EARLY MICROBIAL COLONIZATION; DISEASE-ASSOCIATED BACTERIA; ADHESION MOLECULE-1 ELAM-1; HUMAN GINGIVAL FIBROBLASTS; HUMAN SUBGINGIVAL PLAQUE; MEMBRANE-BOUND CD14; SURFACES IN-VIVO; PORPHYROMONAS-GINGIVALIS C1 [Palmer, Robert J., Jr.] Natl Inst Dent & Craniofacial Res, Oral Infect & Immun Branch, NIH, Bethesda, MD USA. [Darveau, Richard] Univ Washington, Dept Periodont, Seattle, WA 98195 USA. [Lamont, Richard J.] Univ Florida, Coll Dent, Dept Oral Biol, Gainesville, FL 32610 USA. [Nyvad, Bente] Univ Aarhus, Fac Hlth Sci, Sch Dent, Aarhus, Denmark. [Teles, Ricardo P.] Forsyth Inst, Dept Periodontol, Boston, MA USA. RP Palmer, RJ (reprint author), Natl Inst Dent & Craniofacial Res, Oral Infect & Immun Branch, NIH, Bethesda, MD USA. EM rjpalmer@dir.nidcr.nih.gov NR 163 TC 6 Z9 6 U1 0 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4419-6083-2 PY 2011 BP 35 EP 68 DI 10.1007/978-1-4419-6084-9_4 D2 10.1007/978-1-4419-6084-9 PG 34 WC Microbiology SC Microbiology GA BSC47 UT WOS:000284120900004 ER PT S AU Fraley, SI Hale, CM Bloom, RJ Celedon, A Lee, JSH Wirtz, D AF Fraley, Stephanie I. Hale, Christopher M. Bloom, Ryan J. Celedon, Alfredo Lee, Jerry S. H. Wirtz, Denis BE Gerecht, S TI Intra- and Extracellular Microrheology of Endothelial Cells in a 3D Matrix SO BIOPHYSICAL REGULATION OF VASCULAR DIFFERENTIATION AND ASSEMBLY SE Biological and Medical Physics Biomedical Engineering LA English DT Article; Book Chapter ID PARTICLE-TRACKING MICRORHEOLOGY; BALLISTIC INTRACELLULAR NANORHEOLOGY; ANGIOGENESIS IN-VITRO; RHO-KINASE; ACTIN-FILAMENTS; PROTEIN-KINASE; LIVING CELLS; TUMOR-CELLS; MIGRATION; NUCLEUS C1 [Fraley, Stephanie I.; Hale, Christopher M.; Bloom, Ryan J.; Lee, Jerry S. H.; Wirtz, Denis] Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA. [Fraley, Stephanie I.; Hale, Christopher M.; Celedon, Alfredo; Wirtz, Denis] Johns Hopkins Univ, Johns Hopkins Phys Sci Oncol Ctr, Baltimore, MD 21218 USA. [Celedon, Alfredo] Pontificia Univ Catolica Chile, Dept Mech Engn, Santiago 6904411, Chile. [Lee, Jerry S. H.] NCI, Ctr Strateg Sci Initiat, Off Director, NIH, Bethesda, MD 20892 USA. RP Wirtz, D (reprint author), Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA. EM wirtz@jhu.edu NR 61 TC 1 Z9 1 U1 0 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 1618-7210 BN 978-1-4419-7834-9 J9 BIOL MED PHYS BIOMED JI Biol. Med. Phys. Biomed. Eng. PY 2011 BP 69 EP 87 DI 10.1007/978-1-4419-7835-6_4 D2 10.1007/978-1-4419-7835-6 PG 19 WC Biology; Biophysics; Developmental Biology SC Life Sciences & Biomedicine - Other Topics; Biophysics; Developmental Biology GA BTE36 UT WOS:000286639000004 ER PT S AU Finzi, L Manzo, C Zurla, C Wang, HW Lewis, D Adhya, S Dunlap, D AF Finzi, Laura Manzo, Carlo Zurla, Chiara Wang, Haowei Lewis, Dale Adhya, Sankar Dunlap, David BE Williams, MC Maher, LJ TI DNA Looping in Prophage Lambda: New Insight from Single-Molecule Microscopy SO BIOPHYSICS OF DNA- PROTEIN INTERACTIONS: FROM SINGLE MOLECULES TO BIOLOGICAL SYSTEMS SE Biological and Medical Physics Biomedical Engineering LA English DT Article; Book Chapter ID TETHERED PARTICLE MOTION; ION-CHANNEL KINETICS; COOPERATIVE OPERATOR BINDING; BACTERIOPHAGE-LAMBDA; GENE-REGULATION; TRANSCRIPTION ACTIVATION; CRYSTAL-STRUCTURE; CI REPRESSOR; PHAGE-LAMBDA; MODEL C1 [Finzi, Laura; Dunlap, David] Emory Univ, Dept Cell Biol, Atlanta, GA 30322 USA. [Finzi, Laura] Emory Univ, Dept Phys, Atlanta, GA 30322 USA. [Manzo, Carlo] Inst Bioengn Catalonia, Barcelona, Spain. [Zurla, Chiara] Georgia Inst Technol, Dept Bioengn, Atlanta, GA 30332 USA. [Wang, Haowei] Georgia Inst Technol, Dept Phys, Atlanta, GA 30322 USA. [Lewis, Dale; Adhya, Sankar] NCI, Mol Biol Lab, NIH, Bethesda, MD 20892 USA. RP Finzi, L (reprint author), Emory Univ, Dept Cell Biol, 615 Michael St, Atlanta, GA 30322 USA. EM lfinzi@physics.emory.edu RI Manzo, Carlo/B-9745-2012 OI Manzo, Carlo/0000-0002-8625-0996 NR 50 TC 2 Z9 2 U1 0 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 1618-7210 BN 978-0-387-92807-4 J9 BIOL MED PHYS BIOMED JI Biol. Med. Phys. Biomed. Eng. PY 2011 BP 193 EP 212 DI 10.1007/978-0-387-92808-1_9 D2 10.1007/978-0-387-92808-1 PG 20 WC Biology; Biophysics; Engineering, Biomedical SC Life Sciences & Biomedicine - Other Topics; Biophysics; Engineering GA BRS06 UT WOS:000283519500009 ER PT B AU Asagoshi, K Wilson, SH AF Asagoshi, Kenjiro Wilson, Samuel H. BE Penning, TM TI Base-Excision Repair: Role of DNA Polymerase beta in Late-Stage Base Excision Repair SO CHEMICAL CARCINOGENESIS SE Current Cancer Research LA English DT Article; Book Chapter ID CELL NUCLEAR ANTIGEN; PHOSPHATE LYASE ACTIVITY; MAMMALIAN-CELLS; FLAP ENDONUCLEASE-1; ABASIC SITES; IN-VITRO; INDUCED CYTOTOXICITY; PURIFIED PROTEINS; OXIDATIVE STRESS; BOVINE TESTIS AB The cellular DNA repair pathway known as base-excision repair is responsible for removing toxic base lesions and strand breaks from genomic and mitochondrial DNA. The base-excision repair pathway is conserved in organisms throughout nature, but there are many variations probably reflecting the broad range of genotoxic stresses encountered and the gene expression status of the organism. There has been remarkable progress in recent years toward deciphering the various types of base lesions and the multiple steps and subpathways involved in the overall base excision pathway. This progress is reviewed here, and a detailed discussion of current research on the long-patch base-excision repair subpathway is presented. C1 [Asagoshi, Kenjiro; Wilson, Samuel H.] NIEHS, Struct Biol Lab, NIH, Res Triangle Pk, NC 27709 USA. RP Wilson, SH (reprint author), NIEHS, Struct Biol Lab, NIH, POB 12233, Res Triangle Pk, NC 27709 USA. EM kenjiro_asagoshi@med.unc.edu; wilson5@niehs.nih.gov NR 82 TC 2 Z9 2 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-61737-994-9 J9 CURR CANCER RES PY 2011 BP 297 EP 319 DI 10.1007/978-1-61737-995-6_14 D2 10.1007/978-1-61737-995-6 PG 23 WC Oncology; Pharmacology & Pharmacy SC Oncology; Pharmacology & Pharmacy GA BUD31 UT WOS:000288919300014 ER PT S AU Solomon, BD Collmann, H Kress, W Muenke, M AF Solomon, B. D. Collmann, H. Kress, W. Muenke, M. BE Muenke, M Kress, W Collmann, H Solomon, BD TI Craniosynostosis: A Historical Overview SO CRANIOSYNOSTOSES: MOLECULAR GENETICS, PRINCIPLES OF DIAGNOSIS, AND TREATMENT SE Monographs in Human Genetics LA English DT Article; Book Chapter ID SAETHRE-CHOTZEN SYNDROME; PFEIFFER-SYNDROME; CROUZON-SYNDROME; IDENTICAL MUTATIONS; FGFR2; GENE; TWIST AB Craniosynostosis has been recognized since ancient times, and the condition has a colorful and diverse history. In this introductory chapter, we include a description of historical aspects of craniosynostosis, which touches upon ancient depictions of the condition, the advent of modern classification schemes, more recent gene discoveries involving the molecular causes of many types of craniosynostosis, and evolving aspects of the management of affected patients. Copyright (C) 2011 S. Karger AG, Basel C1 [Solomon, B. D.; Muenke, M.] NHGRI, Med Genet Branch, NIH, Bethesda, MD 20892 USA. [Kress, W.] Univ Wurzburg, Inst Human Genet, D-8700 Wurzburg, Germany. [Collmann, H.] Univ Wurzburg, Dept Neurosurg, D-8700 Wurzburg, Germany. RP Muenke, M (reprint author), NHGRI, Med Genet Branch, NIH, MSC 3717,Bldg 35,Room 1B-203, Bethesda, MD 20892 USA. EM mamuenke@mail.nih.gov; mamuenke@mail.nih.gov NR 33 TC 0 Z9 1 U1 0 U2 0 PU KARGER PI BASEL PA POSTFACH, CH-4009 BASEL, SWITZERLAND SN 0077-0876 BN 978-3-8055-9595-7 J9 MONOGR HUM GENET JI Monogr. Hum. Genet. PY 2011 VL 19 BP 1 EP 7 PG 7 WC Genetics & Heredity SC Genetics & Heredity GA BUD41 UT WOS:000288923200001 ER PT S AU Collmann, H Solomon, BD Schweitzer, T Kress, W Muenke, M AF Collmann, H. Solomon, B. D. Schweitzer, T. Kress, W. Muenke, M. BE Muenke, M Kress, W Collmann, H Solomon, BD TI Nonsyndromic Craniosynostoses SO CRANIOSYNOSTOSES: MOLECULAR GENETICS, PRINCIPLES OF DIAGNOSIS, AND TREATMENT SE Monographs in Human Genetics LA English DT Article; Book Chapter ID SINGLE-SUTURE CRANIOSYNOSTOSIS; SAGITTAL SYNOSTOSIS; CORONAL SYNOSTOSIS; METOPIC SYNOSTOSIS; LARGE COHORT; MUTATIONS; GENES; TWINS; MANAGEMENT; PHENOTYPE AB The subtypes of nonsyndromic ('isolated') craniosynostosis are denominated according to the predominant deformity resulting from premature fusion of one of the major cranial sutures: scaphocephaly, trigonocephaly, anterior plagiocephaly, brachycephaly, posterior plagiocephaly, and oxycephaly. In most cases the underlying causes remain unknown although there is some overlap with syndromic craniosynostosis suggesting heterogeneous etiologies. In contrast to the oversimplified nomenclature, isolated craniosynostosis may involve two or more sutures at the same time or may progress with increasing age, thus indicating that the basic nature of craniosynostosis is a failure of growth regulation of the skull rather than a malformation. Copyright (C) 2011 S. Karger AG, Basel C1 [Collmann, H.; Schweitzer, T.] Univ Wurzburg, Dept Pedriatr Neurosurg, Sect Pediat Neurosurg, D-97074 Wurzburg, Germany. [Solomon, B. D.; Muenke, M.] NHGRI, Med Genet Branch, NIH, Bethesda, MD 20892 USA. [Kress, W.] Univ Wurzburg, Inst Human Genet, D-97074 Wurzburg, Germany. RP Collmann, H (reprint author), Univ Wurzburg, Dept Pedriatr Neurosurg, Sect Pediat Neurosurg, Josef Schneider Str 2, D-97074 Wurzburg, Germany. EM collmann.h@nch.uni-wuerzburg.de; collmann.h@nch.uni-wuerzburg.de RI Schweitzer, Tilmann/K-6471-2014 NR 52 TC 1 Z9 1 U1 0 U2 0 PU KARGER PI BASEL PA POSTFACH, CH-4009 BASEL, SWITZERLAND SN 0077-0876 BN 978-3-8055-9595-7 J9 MONOGR HUM GENET JI Monogr. Hum. Genet. PY 2011 VL 19 BP 165 EP 176 PG 12 WC Genetics & Heredity SC Genetics & Heredity GA BUD41 UT WOS:000288923200014 ER PT B AU Hsueh, YP Lin, XR Kwon-Chung, KJ Heitman, J AF Hsueh, Yen-Ping Lin, Xiaorong Kwon-Chung, Kyung J. Heitman, Joseph BE Heitman, J Kozel, TR KwonChung, KJ Perfect, JR Casadevall, A TI Sexual Reproduction of Cryptococcus SO CRYPTOCOCCUS: FROM HUMAN PATHOGEN TO MODEL YEAST LA English DT Article; Book Chapter ID FUNGAL PATHOGEN CRYPTOCOCCUS; PROTEIN-COUPLED RECEPTORS; HOMOBASIDIOMYCETE SCHIZOPHYLLUM-COMMUNE; NEOFORMANS VAR. GRUBII; ALPHA-FACTOR RECEPTOR; MANURE FILTRATE AGAR; MATING-TYPE LOCUS; FILOBASIDIELLA-NEOFORMANS; PHEROMONE RECEPTOR; SACCHAROMYCES-CEREVISIAE C1 [Hsueh, Yen-Ping] CALTECH, Div Biol, Pasadena, CA 91125 USA. [Heitman, Joseph] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA. [Lin, Xiaorong] Texas A&M Univ, Dept Biol, College Stn, TX 77843 USA. [Kwon-Chung, Kyung J.] NIAID, Mol Microbiol Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA. RP Hsueh, YP (reprint author), CALTECH, Div Biol, Pasadena, CA 91125 USA. NR 175 TC 3 Z9 3 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA BN 978-1-55581-501-1 PY 2011 BP 81 EP 96 PG 16 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA BSJ71 UT WOS:000284727500007 ER PT B AU Idnurm, A Williamson, PR AF Idnurm, Alexander Williamson, Peter R. BE Heitman, J Kozel, TR KwonChung, KJ Perfect, JR Casadevall, A TI Genetic and Genomic Approaches to Cryptococcus Environmental and Host Responses SO CRYPTOCOCCUS: FROM HUMAN PATHOGEN TO MODEL YEAST LA English DT Article; Book Chapter ID ORGAN TRANSPLANT RECIPIENTS; NEOFORMANS VAR. GRUBII; CENTRAL-NERVOUS-SYSTEM; MATING-TYPE LOCUS; A MATA STRAIN; AGROBACTERIUM-TUMEFACIENS; INSERTIONAL MUTAGENESIS; SIGNALING PATHWAY; BINDING-PROTEIN; VIRULENCE GENES C1 [Idnurm, Alexander] Univ Missouri, Div Cell Biol & Biophys, Sch Biol Sci, Kansas City, MO 64110 USA. [Williamson, Peter R.] NIAID, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA. RP Idnurm, A (reprint author), Univ Missouri, Div Cell Biol & Biophys, Sch Biol Sci, 5100 Rockhill Rd, Kansas City, MO 64110 USA. NR 72 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA BN 978-1-55581-501-1 PY 2011 BP 127 EP 137 PG 11 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA BSJ71 UT WOS:000284727500010 ER PT B AU Nielsen, K Kwon-Chung, KJ AF Nielsen, Kirsten Kwon-Chung, Kyung J. BE Heitman, J Kozel, TR KwonChung, KJ Perfect, JR Casadevall, A TI A Role for Mating in Cryptococcal Virulence SO CRYPTOCOCCUS: FROM HUMAN PATHOGEN TO MODEL YEAST LA English DT Article; Book Chapter ID FUNGAL PATHOGEN CRYPTOCOCCUS; NEOFORMANS SEROTYPE-A; BRITISH-COLUMBIA; VANCOUVER-ISLAND; SEXUAL CYCLE; FILOBASIDIELLA-NEOFORMANS; ANTIOXIDANT DEFENSE; TUP1 DISRUPTION; ALPHA-STRAINS; MATA STRAIN C1 [Nielsen, Kirsten] Univ Minnesota, Sch Med, Dept Microbiol, Minneapolis, MN 55455 USA. [Kwon-Chung, Kyung J.] NIAID, Mol Microbiol Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA. RP Nielsen, K (reprint author), Univ Minnesota, Sch Med, Dept Microbiol, Minneapolis, MN 55455 USA. NR 88 TC 2 Z9 2 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA BN 978-1-55581-501-1 PY 2011 BP 167 EP + PG 9 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA BSJ71 UT WOS:000284727500013 ER PT S AU Kanungo, J Zheng, YL Rudrabhatla, P Amin, ND Mishra, B Pant, HC AF Kanungo, Jyotshnabala Zheng, Ya-li Rudrabhatla, Parvathi Amin, Niranjana D. Mishra, Bibhutibhushan Pant, Harish C. BE Nixon, RA Yuan, A TI Deregulation of Cytoskeletal Protein Phosphorylation and Neurodegeneration SO CYTOSKELETON OF THE NERVOUS SYSTEM SE Advances in Neurobiology LA English DT Article; Book Chapter DE AD; ALS; Neurodegeneration; Neurofilament; Phosphorylation; Proline-directed kinases; Tau ID CYCLIN-DEPENDENT KINASE-5; AMYOTROPHIC-LATERAL-SCLEROSIS; PAIRED HELICAL FILAMENTS; WEIGHT NEUROFILAMENT PROTEIN; NEURONAL INTERMEDIATE FILAMENTS; MICROTUBULE-ASSOCIATED PROTEINS; GLYCOGEN-SYNTHASE KINASE-3; FETAL-TYPE PHOSPHORYLATION; ALZHEIMERS-DISEASE; TAU-PROTEIN AB Phosphorylation of cytoskeletal proteins is tightly regulated by the activities of multiple protein kinases and phosphatases. Three kinases, Cyclin-dependent kinase 5 (Cdk5), Glycogen synthase kinase 3 beta (GSK3 beta) and MAPKs have been implicated in their direct involvement in neuronal cytoskeletal protein phosphorylation. Cdk5 and GSK3 beta have been identified as prime candidates for pathogenesis. Cdk5 is a proline-directed serine/threonine protein kinase that requires an interaction with its activators, p35 or p39, to be catalytically active. While Cdk5 expression is ubiquitous, p35 and p39 are abundantly expressed in postmitotic neurons which, therefore, exhibit enhanced levels of Cdk5 activity. A pleiotropic kinase, Cdk5 has a multifunctional role in the mammalian central nervous system. Cdk5 was originally identified as a major Tau kinase. It associates with early stages of neurofibrillary tangles (NFTs). NFTs are composed mainly of hyperphosphorylated Tau aggregates, the pathological hallmarks of neurodegenerative tauopathies and Alzheimer's disease (AD). Cdk5, by phosphorylating neuronal cytoskeletal proteins, such as Tau and neurofilaments (NFs), plays a critical role in neurodegeneration. In this review, we focus on the specific roles of Cdk5 phosphorylation of the neuronal cytoskeletal proteins (NFs and Tau) that contribute to neurodegeneration. C1 [Kanungo, Jyotshnabala; Zheng, Ya-li; Rudrabhatla, Parvathi; Amin, Niranjana D.; Pant, Harish C.] Natl Inst Neurol Disorders & Stroke, Neurochem Lab, NIH, Bethesda, MD 20892 USA. [Mishra, Bibhutibhushan] Georgetown Univ, Sch Med, Dev Neurobiol Lab, Washington, DC 20007 USA. RP Pant, HC (reprint author), Natl Inst Neurol Disorders & Stroke, Neurochem Lab, NIH, Bethesda, MD 20892 USA. EM kanungo@fda.hhs.gov; yalinew@yahoo.com; parvathir@ninds.nih.gov; aminn@ninds.nih.gov; bm72@georgetown.edu; panth@ninds.nih.gov NR 167 TC 2 Z9 2 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 2190-5215 BN 978-1-4419-6786-2 J9 ADV NEUROBIOL JI Adv. Neurobiol. PY 2011 VL 3 BP 297 EP 324 DI 10.1007/978-1-4419-6787-9_14 D2 10.1007/978-1-4419-6787-9 PG 28 WC Biology; Neurosciences SC Life Sciences & Biomedicine - Other Topics; Neurosciences & Neurology GA BTS28 UT WOS:000287955100014 ER PT B AU Iozzo, RV Goldoni, S Berendsen, AD Young, MF AF Iozzo, Renato V. Goldoni, Silvia Berendsen, Agnes D. Young, Marian F. BE Mecham, RP TI Small Leucine-Rich Proteoglycans SO EXTRACELLULAR MATRIX: AN OVERVIEW SE Biology of Extracellular Matrix LA English DT Article; Book Chapter ID EPIDERMAL-GROWTH-FACTOR; DECORIN-DEFICIENT MICE; CHONDROITIN SULFATE PROTEOGLYCAN; STATIONARY NIGHT BLINDNESS; ABNORMAL COLLAGEN FIBRILS; CYCLIN-DEPENDENT KINASES; NECROSIS-FACTOR-ALPHA; COMPLETE CDNA CLONING; HUMAN COLON-CARCINOMA; SMOOTH-MUSCLE-CELLS AB The small leucine-rich proteoglycans (SLRPs) comprise an expanding family of proteoglycans and glycoproteins that now encompass five distinct groups including three canonical and two noncanonical classes based on shared structural and functional parameters. SLRPs are tissue organizers by orienting and ordering various collagenous matrices during ontogeny, wound repair, and cancer and interact with a number of surface receptors and growth factors, thereby regulating cell behavior. The focus of this chapter is on novel conceptual and functional advances in our understanding of SLRP biology with special emphasis on genetic diseases, cancer growth, fibrosis, osteoporosis, and other biological processes where these proteoglycans play a central role. C1 [Iozzo, Renato V.; Goldoni, Silvia] Thomas Jefferson Univ, Kimmel Canc Ctr, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA. [Iozzo, Renato V.; Goldoni, Silvia] Thomas Jefferson Univ, Kimmel Canc Ctr, Canc Cell Biol & Signaling Program, Philadelphia, PA 19107 USA. [Berendsen, Agnes D.; Young, Marian F.] NIDCR, Craniofacial & Skeletal Dis Branch, Mol Biol Bones & Teeth Sect, NIH, Bethesda, MD 20892 USA. RP Iozzo, RV (reprint author), Thomas Jefferson Univ, Kimmel Canc Ctr, Dept Pathol Anat & Cell Biol, Room 249 JAH,1020 Locust St, Philadelphia, PA 19107 USA. EM iozzo@mail.jci.tju.edu NR 197 TC 25 Z9 25 U1 0 U2 3 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY BN 978-3-642-16554-2 J9 BIOL EXTRACELL MATR PY 2011 BP 197 EP 231 DI 10.1007/978-3-642-16555-9_6 D2 10.1007/978-3-642-16555-9 PG 35 WC Cell Biology SC Cell Biology GA BTW03 UT WOS:000288227100006 ER PT B AU Roberts, DD Lau, LF AF Roberts, David D. Lau, Lester F. BE Mecham, RP TI Matricellular Proteins SO EXTRACELLULAR MATRIX: AN OVERVIEW SE Biology of Extracellular Matrix LA English DT Article; Book Chapter ID TISSUE-GROWTH-FACTOR; OLIGOMERIC MATRIX PROTEIN; SINGLE-NUCLEOTIDE POLYMORPHISMS; ENDOTHELIAL-CELL PROLIFERATION; THROMBOSPONDIN TYPE-1 REPEATS; SMOOTH-MUSCLE-CELLS; PROGRESSIVE PSEUDORHEUMATOID DYSPLASIA; ANGIOGENESIS INHIBITOR ABT-510; ISCHEMIA-REPERFUSION INJURY; MOUSE EMBRYONIC-DEVELOPMENT AB In addition to its major structural elements, extracellular matrix contains a number of factors that are important for orchestrating developmental morphogenesis, maintaining tissue homeostasis in adults, and regenerating tissue following injury. Several proteins that serve these functions share a complex modular structure that enables them to interact with specific components of the matrix while engaging specific cell surface receptors through which they control cell behavior. These have been named matricellular proteins. Matricellular proteins, including the thrombospondins, some thrombospondin-repeat superfamily members, tenascins, SPARC, CCN proteins, and SIBLING proteins, are increasingly recognized to play important roles in inherited disorders, responses to injury and stress, and the pathogenesis of several chronic diseases of aging. Improved understanding of the functions and mechanisms of action of matricellular proteins is beginning to yield novel therapeutic strategies for prevention or treatment of these diseases. C1 [Roberts, David D.] NCI, Pathol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. [Lau, Lester F.] Univ Illinois, Coll Med, Dept Biochem & Mol Genet, Chicago, IL 60607 USA. RP Roberts, DD (reprint author), NCI, Pathol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. EM droberts@helix.nih.gov; LFLau@uic.edu RI Roberts, David/A-9699-2008 OI Roberts, David/0000-0002-2481-2981 NR 298 TC 3 Z9 3 U1 0 U2 4 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY BN 978-3-642-16554-2 J9 BIOL EXTRACELL MATR PY 2011 BP 369 EP 413 DI 10.1007/978-3-642-16555-9_11 D2 10.1007/978-3-642-16555-9 PG 45 WC Cell Biology SC Cell Biology GA BTW03 UT WOS:000288227100011 ER PT B AU Kaufmann, SHE Rouse, B Sacks, D AF Kaufmann, Stefan H. E. Rouse, Barry Sacks, David BE Kaufmann, SHE Rouse, BT Sacks, DL TI The Immune Response to Infection: Introduction SO IMMUNE RESPONSE TO INFECTION LA English DT Editorial Material; Book Chapter C1 [Kaufmann, Stefan H. E.] Max Planck Inst Infect Biol, Dept Immunol, D-10117 Berlin, Germany. [Rouse, Barry] Univ Tennessee, Dept Pathobiol, Knoxville, TN 37996 USA. [Sacks, David] NIAID, Parasit Dis Lab, Intracellular Parasite Biol Sect, Bethesda, MD 20892 USA. RP Kaufmann, SHE (reprint author), Max Planck Inst Infect Biol, Dept Immunol, Charitepl 1, D-10117 Berlin, Germany. NR 4 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA BN 978-1-55581-514-1 PY 2011 BP 1 EP 4 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA BSQ56 UT WOS:000285482300001 ER PT B AU Belkaid, Y Sehrawat, S Rouse, BT AF Belkaid, Yasmine Sehrawat, Sharvan Rouse, Barry T. BE Kaufmann, SHE Rouse, BT Sacks, DL TI Regulation of Antimicrobial Immunity SO IMMUNE RESPONSE TO INFECTION LA English DT Article; Book Chapter ID T-HELPER TYPE-1; VIRAL-INDUCED IMMUNOPATHOLOGY; TRANSCRIPTION FACTOR FOXP3; TGF-BETA; CELLS CONTROL; IMMUNOINFLAMMATORY LESIONS; PROTECTIVE IMMUNITY; IL-2 PRODUCTION; IN-VIVO; INFECTION C1 [Belkaid, Yasmine] NIH, Mucosal Immunol Unit, Parasit Dis Lab, Div Intramural Res, Bethesda, MD 20892 USA. [Sehrawat, Sharvan; Rouse, Barry T.] Univ Tennessee, Coll Vet Med, Dept Pathobiol, Knoxville, TN 37996 USA. RP Belkaid, Y (reprint author), NIH, Mucosal Immunol Unit, Parasit Dis Lab, Div Intramural Res, 4 Ctr Dr B1-28, Bethesda, MD 20892 USA. NR 79 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA BN 978-1-55581-514-1 PY 2011 BP 109 EP 120 PG 12 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA BSQ56 UT WOS:000285482300009 ER PT B AU Hunter, CA Sher, A AF Hunter, Christopher A. Sher, Alan BE Kaufmann, SHE Rouse, BT Sacks, DL TI Innate Immunity to Parasitic Infections SO IMMUNE RESPONSE TO INFECTION LA English DT Article; Book Chapter ID NATURAL-KILLER-CELLS; COMPLEMENT REGULATORY PROTEIN; TRYPANOSOMA-CRUZI INFECTION; TOXOPLASMA-GONDII INFECTION; MANNOSE-BINDING LECTIN; GROWTH-FACTOR-BETA; HUMAN NK CELLS; DENDRITIC CELLS; LEISHMANIA-MAJOR; ENTAMOEBA-HISTOLYTICA C1 [Hunter, Christopher A.] Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA. [Sher, Alan] NIAID, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA. RP Hunter, CA (reprint author), Univ Penn, Sch Vet Med, Dept Pathobiol, Rm 313,Hill Pavil,380 S Univ Ave, Philadelphia, PA 19104 USA. NR 108 TC 0 Z9 0 U1 0 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA BN 978-1-55581-514-1 PY 2011 BP 225 EP 236 PG 12 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA BSQ56 UT WOS:000285482300019 ER PT B AU Wynn, TA Allen, JE AF Wynn, Thomas A. Allen, Judith E. BE Kaufmann, SHE Rouse, BT Sacks, DL TI Pathogenesis of Helminth Infections SO IMMUNE RESPONSE TO INFECTION LA English DT Article; Book Chapter ID ALTERNATIVELY ACTIVATED MACROPHAGES; SCHISTOSOMA-MANSONI EGGS; ANTIGEN-PRESENTING CELLS; SYNTHASE ARGINASE BALANCE; NITRIC-OXIDE PRODUCTION; CHITINASE-LIKE PROTEINS; NIPPOSTRONGYLUS-BRASILIENSIS; MURINE SCHISTOSOMIASIS; PROTECTIVE IMMUNITY; BRUGIA-MALAYI C1 [Wynn, Thomas A.] NIAID, Immunopathogenesis Sect, NIH, Bethesda, MD 20892 USA. [Allen, Judith E.] Univ Edinburgh, Inst Evolut Immunol & Infect Res, Edinburgh EH9 3JT, Midlothian, Scotland. RP Wynn, TA (reprint author), NIAID, Immunopathogenesis Sect, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. NR 146 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA BN 978-1-55581-514-1 PY 2011 BP 347 EP 359 PG 13 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA BSQ56 UT WOS:000285482300029 ER PT B AU Amaratunga, C Lopera-Mesa, TM Tse, JG Mita-Mendoza, NK Fairhurst, RM AF Amaratunga, Chanaki Lopera-Mesa, Tatiana M. Tse, Jeanette G. Mita-Mendoza, Neida K. Fairhurst, Rick M. BE Kaufmann, SHE Rouse, BT Sacks, DL TI Pathology and Pathogenesis of Malaria SO IMMUNE RESPONSE TO INFECTION LA English DT Article; Book Chapter ID PLASMODIUM-FALCIPARUM MALARIA; HUMAN CEREBRAL MALARIA; RED-BLOOD-CELLS; CAVEOLA-VESICLE COMPLEXES; PAPUA-NEW-GUINEA; VIVAX MALARIA; INFECTED ERYTHROCYTES; HEMOGLOBIN-C; RESPIRATORY-DISTRESS; PARASITIZED ERYTHROCYTES C1 [Amaratunga, Chanaki; Lopera-Mesa, Tatiana M.; Tse, Jeanette G.; Mita-Mendoza, Neida K.; Fairhurst, Rick M.] NIAAA, Lab Malaria & Vector Res, Rockville, MD 20852 USA. RP Amaratunga, C (reprint author), NIAAA, Lab Malaria & Vector Res, Rockville, MD 20852 USA. NR 150 TC 0 Z9 0 U1 0 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA BN 978-1-55581-514-1 PY 2011 BP 361 EP 381 PG 21 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA BSQ56 UT WOS:000285482300030 ER PT B AU Graham, BS Walker, C AF Graham, Barney S. Walker, Christopher BE Kaufmann, SHE Rouse, BT Sacks, DL TI Meeting the Challenge of Vaccine Design To Control HIV and Other Difficult Viruses SO IMMUNE RESPONSE TO INFECTION LA English DT Article; Book Chapter ID HEPATITIS-C VIRUS; RESPIRATORY SYNCYTIAL VIRUS; HUMAN-IMMUNODEFICIENCY-VIRUS; ADAPTIVE IMMUNE-RESPONSES; T-CELL IMMUNITY; NEUTRALIZING ANTIBODIES; INFECTION; CHIMPANZEES; TRANSMISSION; ESCAPE C1 [Graham, Barney S.] NIAID, Vaccine Res Ctr, Bethesda, MD 20892 USA. [Walker, Christopher] Ohio State Univ, Nationwide Childrens Hosp, Columbus, OH 43205 USA. [Walker, Christopher] Ohio State Univ, Dept Pediat, Columbus, OH 43205 USA. [Walker, Christopher] Ohio State Univ, Dept Pathol, Columbus, OH 43205 USA. [Walker, Christopher] Ohio State Univ, Dept Mol Virol, Columbus, OH 43205 USA. RP Graham, BS (reprint author), NIAID, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA. NR 59 TC 2 Z9 2 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA BN 978-1-55581-514-1 PY 2011 BP 559 EP 570 PG 12 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA BSQ56 UT WOS:000285482300045 ER PT B AU Long, CA Zavala, FP AF Long, Carole A. Zavala, Fidel P. BE Kaufmann, SHE Rouse, BT Sacks, DL TI Immune Intervention in Malaria SO IMMUNE RESPONSE TO INFECTION LA English DT Article; Book Chapter ID PLASMODIUM-FALCIPARUM INFECTION; X-IRRADIATED SPOROZOITES; CD8+ T-CELLS; CIRCUMSPOROZOITE PROTEIN; PROTECTIVE IMMUNITY; VACCINE DEVELOPMENT; ACQUIRED-IMMUNITY; VIVAX MALARIA; IN-VITRO; SURFACE C1 [Long, Carole A.] NIAID, Malaria Immunol Sect, Lab Malaria & Vector Res, NIH, Rockville, MD 20852 USA. [Zavala, Fidel P.] Johns Hopkins Univ, Dept Mol Microbiol & Immun, Bloomberg Sch Publ Hlth, Malaria Res Inst, Baltimore, MD 21205 USA. RP Long, CA (reprint author), NIAID, Malaria Immunol Sect, Lab Malaria & Vector Res, NIH, Rockville, MD 20852 USA. NR 69 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA BN 978-1-55581-514-1 PY 2011 BP 587 EP 597 PG 11 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA BSQ56 UT WOS:000285482300047 ER PT B AU McDowell, MA Kamhawi, S AF McDowell, Mary Ann Kamhawi, Shaden BE Kaufmann, SHE Rouse, BT Sacks, DL TI Targeting Components in Vector Saliva SO IMMUNE RESPONSE TO INFECTION LA English DT Article; Book Chapter ID SAND FLY SALIVA; LUTZOMYIA-LONGIPALPIS COMPLEX; ANTI-MOSQUITO ANTIBODIES; HOST IMMUNE-RESPONSE; LEISHMANIA-MAJOR; VISCERAL LEISHMANIASIS; PLASMODIUM-BERGHEI; GLAND EXTRACTS; AEDES-AEGYPTI; IMMUNOMODULATORY PROPERTIES C1 [McDowell, Mary Ann] Univ Notre Dame, Dept Biol Sci, Eck Inst Global Hlth & Infect Dis, Notre Dame, IN 46556 USA. [Kamhawi, Shaden] NIAID, Lab Malaria & Vector Res, NIH, Rockville, MD 20852 USA. RP McDowell, MA (reprint author), Univ Notre Dame, Dept Biol Sci, Eck Inst Global Hlth & Infect Dis, Notre Dame, IN 46556 USA. NR 87 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA BN 978-1-55581-514-1 PY 2011 BP 599 EP 608 PG 10 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA BSQ56 UT WOS:000285482300048 ER PT B AU Shanker, A AF Shanker, Anil BE Marincola, FM Wang, E TI The Immune Rejection: Lessons from Experimental Models SO IMMUNOLOGIC SIGNATURES OF REJECTION LA English DT Article; Book Chapter ID TUMOR-NECROSIS-FACTOR; NATURAL-KILLER-CELLS; REGULATORY T-CELLS; ADIPOSE-TISSUE; INNATE IMMUNITY; IFN-GAMMA; PROTECTIVE IMMUNITY; ANTITUMOR IMMUNITY; OBESITY; CHILDREN AB The mechanisms of immune rejection depend on a complex interplay between the elements of innate and adaptive immunity. Several studies in animal models of cancer and other conditions, including obesity and intestinal microbiome, over the past decade have provided evidence for an intricate cross-regulation of innate resistance and adaptive immunity. More recently, it became apparent that adaptive immunity, besides its effector function, also controls innate immune responses beyond its role in immune complex-Fc receptor interaction. This has led to a paradigm shift from the classical unidirectional notion of the innate instruction of adaptive immunity to a bidirectional partnership of the innate and adaptive immune system in controlling various pathological and physiological conditions. This chapter summarizes the advances in our understanding of the mechanisms of immune reactivity in the models of intestinal microbiota, acute infections, obesity, and cancer. C1 [Shanker, Anil] NCI, Expt Immunol Lab, Canc & Inflammat Program, Frederick, MD 21701 USA. [Shanker, Anil] SAIC Frederick Inc, Basic Sci Program, Frederick, MD USA. RP Shanker, A (reprint author), NCI, Expt Immunol Lab, Canc & Inflammat Program, Frederick, MD 21701 USA. EM shankera@mail.nih.gov OI Shanker, Anil/0000-0001-6372-3669 NR 45 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4419-7218-7 PY 2011 BP 17 EP 25 DI 10.1007/978-1-4419-7219-4_3 D2 10.1007/978-1-4419-7219-4 PG 9 WC Oncology SC Oncology GA BSH95 UT WOS:000284503300003 ER PT B AU Wang, E Marincola, FM AF Wang, Ena Marincola, Francesco M. BE Marincola, FM Wang, E TI Immune-Mediated Tumor Rejection SO IMMUNOLOGIC SIGNATURES OF REJECTION LA English DT Article; Book Chapter ID POSTTRANSPLANT LYMPHOPROLIFERATIVE DISEASE; NATURAL-KILLER-CELLS; SOLID-ORGAN TRANSPLANTATION; VERSUS-HOST-DISEASE; CLASS-I EXPRESSION; CYTOTOXIC T-CELLS; C VIRUS-INFECTION; GENE-EXPRESSION; VACCINIA-VIRUS; SPONTANEOUS REGRESSION AB Fundamental strides in the understanding of the molecular basis of tumor rejection At were made in the last decade thanks to observational studies performed at relevant time points in human cancerous tissues. The following concepts emerged: immune surveillance against tumors is a likely occurrence. When cancer cells evolve to escape the ongoing immune defense, the neoplastic process reaches a clinically observable phase. By necessity, at this stage, escape mechanisms override anti-cancer mechanisms for tumors to be observable. When cancers become established, two molecular phenotypes can usually be observed: one is characterized by a tumor microenvironment infiltrated by immune cells bearing transcriptional signatures consistent with a status of partial activation. Although incapable of dramatically affecting tumor growth, immune infiltration bears a favorable prognostic and/or predictive connotation on the natural history of the disease or its responsiveness to therapy. In this chapter, we will discuss the significance of transcriptional signatures observed in pre-treatment biopsies as predictive of responsiveness to biological therapy. Moreover, we will discuss the transcriptional signatures observable during and after therapy documenting the switch from chronic to acute inflammation that leads to tumor rejection. We will further discuss how chemotherapy and viral oncolytic therapy, both believed to eliminate tumors exclusively through direct cytotoxicity may play an adjuvant role in stimulating this inflammatory switch. Finally, we will discuss how mechanisms leading to tumor rejection, largely overlap those associated with other aspects of immune-mediated tissue-specific destruction (TSD) such as allograft rejection, graft vs. host disease, acute clearance of pathogen and autoimmunity. C1 [Wang, Ena; Marincola, Francesco M.] NIH, IDIS, Dept Transfus Med, Ctr Clin, Bethesda, MD 20892 USA. [Wang, Ena; Marincola, Francesco M.] NIH, Trans NIH Ctr Human Immunol CHI, Bethesda, MD 20892 USA. RP Wang, E (reprint author), NIH, IDIS, Dept Transfus Med, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA. EM ewang@mail.cc.nih.gov; FMarincola@mail.cc.nih.gov; FMarincola@mail.cc.nih.gov; ewang@mail.cc.nih.gov NR 138 TC 3 Z9 3 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4419-7218-7 PY 2011 BP 281 EP 304 DI 10.1007/978-1-4419-7219-4_18 D2 10.1007/978-1-4419-7219-4 PG 24 WC Oncology SC Oncology GA BSH95 UT WOS:000284503300018 ER PT B AU Bedognetti, D AF Bedognetti, Davide BE Marincola, FM Wang, E TI Signatures Associated with Acute Rejection: Allograft Rejection SO IMMUNOLOGIC SIGNATURES OF REJECTION LA English DT Article; Book Chapter ID NF-KAPPA-B; ACUTE CELLULAR REJECTION; CHEMOKINE RECEPTOR CXCR3; HUMAN RENAL-ALLOGRAFTS; KIDNEY-TRANSPLANT REJECTION; TRANSCRIPTION FACTOR IRF-1; ADAPTIVE IMMUNE-RESPONSES; GENE-EXPRESSION PROFILES; TOLL-LIKE RECEPTORS; GROWTH-FACTOR-BETA AB The physiopathology of immune-mediated tissue injury of acute allograft rejection is not completely understood. Although several mechanicistic experiments have been conducted in vitro and in animal models, only few hypotheses have been confirmed in humans and, paradoxically, findings in humans often lack mechanistic explanations. Before high throughput gene expression analysis advent (microarrays), the use of optic microscopy, immunohistochemistry and reverse transcriptase protein chain reaction (RT-PCR), allowed the "in situ" evaluation of only a few variables simultaneously. Conversely, the integration of the aforementioned methodologies with microarrays has cast new lights on unrecognized mechanisms that are now deemed as central for the development of the alloresponse. Pari passu with underlining the molecular heterogeneity between apparently similar lesions, this approach has also unveiled the activation of common mechanisms among clinically and histopathologically different lesions. Universal standardization procedures were slowly and incompletely developed while microarray methodology was at its dawn and in continuing evolution. Moreover, the lack of uniformity among different investigating groups (in terms of sample collect ion, microarray platforms, genes coverage, bioinformatic analysis and study design) has probably been one of the reasons accounting for the relatively small overlap in the relevant genes detected by individual studies. Nevertheless, in spite of the aforementioned limitations, it is difficult to ignore the relevance of those gene/gene pathways consistently detected as simultaneously upregulated among independent studies even in the presence of such technical and analytic limitations. The aim of this chapter is to shed some light on the physiopathology of allorejection, pointing at the activation of genes and molecular pathways thought to play a leading role in the development and/or maintenance of the tissue destructive process, which characterizes acute rejection. Rather than trying to explain the cause of the activation of this acute response, we will try to depict a molecular fresco of the battlefield where tissue destruction is fought. To this purpose, we will focus on human microarray studies performed on tissue biopsies taken during episodes of acute allograft rejection, providing also a brief description of the results obtained with other approaches (RT-PCR or immunohistochemistry). We will apply the knowledge derived from mechanicistic studies and from inductive and deductive reasoning to explain the possible roles and relations of the described pathways. C1 [Bedognetti, Davide] NIH, IDIS, Dept Transfus Med, Ctr Clin, Bethesda, MD 20892 USA. [Bedognetti, Davide] NIH, Trans NIH Ctr Human Immunol CHI, Bethesda, MD 20892 USA. [Bedognetti, Davide] Univ Genoa, Dept Oncol Biol & Genet, Genoa, Italy. [Bedognetti, Davide] Univ Genoa, Dept Internal Med, I-16126 Genoa, Italy. RP Bedognetti, D (reprint author), NIH, IDIS, Dept Transfus Med, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA. EM davide.bedognetti@nih.gov OI Bedognetti, Davide/0000-0002-5857-773X NR 182 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4419-7218-7 PY 2011 BP 305 EP 345 DI 10.1007/978-1-4419-7219-4_19 D2 10.1007/978-1-4419-7219-4 PG 41 WC Oncology SC Oncology GA BSH95 UT WOS:000284503300019 ER PT B AU Simonsen, L Viboud, C Taylor, RJ Miller, MA AF Simonsen, Lone Viboud, Cecile Taylor, Robert J. Miller, Mark A. BE Rappuoli, R DelGiudice, G TI The Epidemiology of Influenza and Its Control SO INFLUENZA VACCINES FOR THE FUTURE, SECOND EDITION SE Birkhauser Advances in Infectious Diseases LA English DT Article; Book Chapter ID RESPIRATORY SYNCYTIAL VIRUS; PANDEMIC INFLUENZA; UNITED-STATES; PUBLIC-HEALTH; HONG-KONG; VACCINATING SCHOOLCHILDREN; ELDERLY PERSONS; CAUSE MORTALITY; A VIRUS; DEATHS AB In this chapter we highlight how recent advances in influenza epidemiology can inform strategies for disease control Given the challenge of direct measurement, influenza epidemiology has benefited greatly from statistical inference from the analysts of large datasets regarding hospitalization, mortality, and outpatient visits associated with seasonal circulation of influenza viruses These data have allowed comparison of the impact of influenza in various climates and the evaluation of the direct and indirect benefits of vaccination, the latter through the vaccination of 'transmitter populations' such as school children, to achieve herd immunity Moreover, the resolution of influenza epidemiology has undergone a leap to the molecular level due to the integration of new antigenic and viral genomic data with classical epidemiological indicators Finally, the new data have led to an infusion of quantitative studies from the fields of evolutionary biology, population genetics and mathematics Molecular influenza epidemiology is providing deeper insight into temporal/spatial patterns of viruses, the important role of reassortment in generating genetic novelty and global diffusion of virus variants - including the role of the tropics as a source of new variants Higher resolution contemporary and historic epidemiological data provide a more detailed picture of the effect of age and other host characteristics on outcomes, as well as better estimates of the transmissibility of pandemic and seasonal influenza viruses New epidemiologic and virologic data from the current A/H1N1pdm 2009 pandemic improve our understanding of the emergence and establishment of new viral subtypes in human populations and their mortality and morbidity burden in the first years of circulation Re-examination of observational studies of vaccine effectiveness in seniors is leading to reconsideration of seasonal and pandemic vaccine priorities, while mathematical modelers have developed tools to explore optimal strategies for mitigating on-going and future pandemics The field of influenza epidemiology has rapidly progressed in the past decade and become truly multidisciplinary Progress could be sustained in the next decade by further interdisciplinary studies between virology, evolutionary biology, immunology, and clinical outcomes C1 [Simonsen, Lone; Viboud, Cecile; Miller, Mark A.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. [Taylor, Robert J.] SAGE Analyt LLC, Bethesda, MD USA. [Simonsen, Lone] George Washington Univ, Sch Publ Hlth & Hlth Serv, Washington, DC USA. RP Miller, MA (reprint author), NIH, Fogarty Int Ctr, Bldg 10, Bethesda, MD 20892 USA. OI Simonsen, Lone/0000-0003-1535-8526 NR 133 TC 6 Z9 7 U1 1 U2 7 PU BIRKHAUSER VERLAG AG PI BASEL PA VIADUKSTRASSE 40-44, PO BOX 133, CH-4010 BASEL, SWITZERLAND BN 978-3-0346-0278-5 J9 BIRKHAUSER ADV INFEC JI Birk. Adv. Infect. Dis. PY 2011 BP 27 EP 54 DI 10.1007/978-3-0346-0279-2_2 D2 10.1007/978-3-0346-0279-2 PG 28 WC Infectious Diseases SC Infectious Diseases GA BSD79 UT WOS:000284236900002 ER PT B AU Luke, CJ Subbarao, K AF Luke, Catherine J. Subbarao, Kanta BE Rappuoli, R DelGiudice, G TI The Role of Animal Models In Influenza Vaccine Research SO INFLUENZA VACCINES FOR THE FUTURE, SECOND EDITION SE Birkhauser Advances in Infectious Diseases LA English DT Article; Book Chapter ID LOWER RESPIRATORY-TRACT; A VIRUS-INFECTION; I RANDOMIZED-TRIAL; H5N1 VIRUSES; HONG-KONG; HETEROSUBTYPIC IMMUNITY; SOUTHERN CHINA; PROTECTIVE IMMUNITY; HEALTHY-ADULTS; INACTIVATED INFLUENZA AB A major challenge for research on influenza vaccines is the selection of an appropriate animal model that accurately reflects the disease and the protective immune response to influenza infection in humans Vaccines for seasonal influenza have been available for decades and there is a wealth of data available on the immune response to these vaccines in humans with well-established correlates of protection for inactivated influenza virus vaccines Many of the seminal studies on vaccines for epidemic influenza have been conducted in human subjects Studies in humans are performed less frequently now than they were in the past Therefore as the quest for improved influenza vaccines continues, it is important to consider the use of animal models for the evaluation of influenza vaccines, and a major challenge is the selection of an appropriate animal model that accurately reflects the disease and the protective immune response to influenza infection in humans The emergence of highly pathogenic H5N1 avian influenza (AI) viruses and the threat of a pandemic caused by AI viruses of this or another subtype has resulted in a resurgence of interest in influenza vaccine research The development of vaccines for pandemic influenza presents a unique set of obstacles not the least of which is that the demonstration of efficacy in humans is not possible As the correlates of protection from pandemic influenza are not known, we rely on extrapolation of the lessons from seasonal influenza vaccines and on data from the evaluation of pandemic influenza vaccines in animal models to guide our decisions on vaccines for use in humans The features and contributions of commonly used animal models for influenza vaccine research are discussed The recent emergence of the pandemic 2009 H1N1 influenza virus underscores the unpredictable nature of influenza viruses and the importance of pandemic preparedness C1 [Luke, Catherine J.; Subbarao, Kanta] NIAID, Infect Dis Lab, NIH, Bethesda, MD 20892 USA. RP Luke, CJ (reprint author), NIAID, Infect Dis Lab, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. NR 184 TC 1 Z9 1 U1 2 U2 3 PU BIRKHAUSER VERLAG AG PI BASEL PA VIADUKSTRASSE 40-44, PO BOX 133, CH-4010 BASEL, SWITZERLAND BN 978-3-0346-0278-5 J9 BIRKHAUSER ADV INFEC JI Birk. Adv. Infect. Dis. PY 2011 BP 223 EP 272 DI 10.1007/978-3-0346-0279-2_10 D2 10.1007/978-3-0346-0279-2 PG 50 WC Infectious Diseases SC Infectious Diseases GA BSD79 UT WOS:000284236900010 ER PT B AU Akagi, K Yi, M Roayaei, J Stephens, RM AF Akagi, Keiko Yi, Ming Roayaei, Jean Stephens, Robert M. BE Dupuy, AJ Largaespada, DA TI Bioinformatics of High-Throughput Insertional Mutagenesis SO INSERTIONAL MUTAGENESIS STRATEGIES IN CANCER GENETICS LA English DT Article; Book Chapter ID GENE SET ENRICHMENT; NEXT-GENERATION; SLEEPING-BEAUTY; SEQUENCE DATABASE; IDENTIFIES GENES; MICROARRAY DATA; SITE SELECTION; ANALYSIS TOOL; MOUSE GENOME; CANCER AB Bioinformatics plays critical roles to handle large amount of sequence data from insertional mutagenesis. First, computational approaches are used to develop rapid sequence analysis pipelines and biological databases. Millions of reads from an insertion mutagenesis screening are mapped to genomic locations and be annotated to their target genes rapidly by pipeline, and such sequence-based data is stored and managed in database to share the information in the scientific community. Second, statistical techniques are used to distinguish true common insertion sites (loci that have been hit by insertions in multiple tumors: candidate loci for cancer genes) from background insertions in large-scale screenings. Finally, the advanced data mining techniques, pathway and network analysis, are used to give further biological meaning to insertion sites by identifying the interaction of genes in cancer. In this chapter, we discuss features of these three topics and address their future roles: (1) development of sequence analysis pipeline and database, (2) detection of common insertion sites, and (3) network and pathway analysis of insertion sites. C1 [Akagi, Keiko] NCI, Mol Canc Genet Program, Ctr Canc Res, Frederick, MD 21702 USA. [Akagi, Keiko] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA. [Yi, Ming; Stephens, Robert M.] NCI, Adv Technol Program, Adv Biomed Comp Ctr, SAIC Frederick Inc, Frederick, MD 21702 USA. [Roayaei, Jean] SAIC Frederick, Stat Consulting Grp, Frederick, MD 21701 USA. RP Akagi, K (reprint author), NCI, Mol Canc Genet Program, Ctr Canc Res, Frederick, MD 21702 USA. EM keiko.akagi@osumc.edu; yiming@mail.nih.gov; roayaei456@mail.nih.gov; stephensr@mail.nih.gov NR 82 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4419-7655-0 PY 2011 BP 167 EP 188 DI 10.1007/978-1-4419-7656-7_7 D2 10.1007/978-1-4419-7656-7 PG 22 WC Oncology; Cell Biology; Genetics & Heredity SC Oncology; Cell Biology; Genetics & Heredity GA BSP87 UT WOS:000285329600007 ER PT B AU Sawitzke, JA AF Sawitzke, James A. BE Maloy, S Hughes, KT Casadesus, J TI RECOMBINEERING: ADVANCED-ADVANCED BACTERIAL GENETICS SO LURE OF BACTERIAL GENETICS: A TRIBUTE TO JOHN ROTH LA English DT Article; Book Chapter ID ESCHERICHIA-COLI; HOMOLOGOUS RECOMBINATION; MISMATCH REPAIR; IN-VIVO; MUTAGENESIS; EFFICIENT; REPLACEMENT; MUTATIONS; SYSTEM C1 NCI, Mol Control & Genet Sect, Gene Regulat & Chromosome Biol Lab, Ctr Canc Res, Frederick, MD 21702 USA. RP Sawitzke, JA (reprint author), NCI, Mol Control & Genet Sect, Gene Regulat & Chromosome Biol Lab, Ctr Canc Res, Frederick, MD 21702 USA. NR 29 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N STREET NW, WASHINGTON, DC 20036-2904 USA BN 978-1-55581-538-7 PY 2011 BP 333 EP 340 PG 8 WC Biochemistry & Molecular Biology; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA BSL44 UT WOS:000284857100032 ER PT B AU Singh, V Amdekar, S Yadav, H Mishra, NN Jain, S AF Singh, Vinod Amdekar, Sarika Yadav, Hariom Mishra, Nagendra Nath Jain, Shailini BE Ahmad, I Ahmad, F Pichtel, J TI Future Application of Probiotics: A Boon from Dairy Biology SO MICROBES AND MICROBIAL TECHNOLOGY: AGRICULTURAL AND ENVIRONMENTAL APPLICATIONS LA English DT Article; Book Chapter ID HUMAN GASTROINTESTINAL-TRACT; LIVE BACTERIAL VACCINES; IMMUNE-SYSTEM; LACTOBACILLUS STRAINS; ROTAVIRUS INFECTION; INTESTINAL MUCUS; FERMENTED MILK; RESPONSES; CELLS; IMMUNIZATION AB Microbes have been used for millenia in food and alcoholic fermentations; in recent years, microbes have undergone scientific scrutiny of their ability for preventive and therapeutic effects in humans. This work has led to the establishment of a new term, "probiotics." Lactic acid bacteria (LAB) are normal microflora of the intestine of most animals. They play an important role in humans and other animals and act as an immunomodulator. LAB are helpful in disease treatment and prevention, as well as for improved digestion and absorption of nutrients. Probiotic microorganisms include LAB i.e., Lactobacillus acidophilus, L. bulgaricus, L. casei, L. plantarum, L. rhamnosus, etc. Use of these live bacteria to elicit an immune response or to carry a vaccine component is a new development in vaccine formulation. The advantages of live bacterial vaccines are their ability to mimic the natural infection, their intrinsic adjuvant properties, and that they can be administered orally. Components of pathogenic and nonpathogenic food-related microbes are currently being evaluated as candidates for oral vaccines. C1 [Singh, Vinod; Amdekar, Sarika] Barkatullah Univ, Dept Microbiol, Bhopal 462026, India. [Yadav, Hariom] NIDDK, Regenerat Biol Sect, Clin Res Ctr, NIH,Diabet Branch, Bethesda, MD 20892 USA. [Mishra, Nagendra Nath] Univ Calif Los Angeles, Los Angeles Biomed Res Inst Harbor, Div Infect Dis, Med Ctr, Torrance, CA 90502 USA. [Jain, Shailini] Univ Illinois, Dept Food Sci & Human Nutr, Urbana, IL 61801 USA. RP Singh, V (reprint author), Barkatullah Univ, Dept Microbiol, Bhopal 462026, India. EM vinodsingh63@yahoo.co.in NR 68 TC 0 Z9 0 U1 0 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4419-7930-8 PY 2011 BP 87 EP 100 DI 10.1007/978-1-4419-7931-5_4 D2 10.1007/978-1-4419-7931-5 PG 14 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA BTP00 UT WOS:000287674400004 ER PT B AU Redon, CE Dickey, JS Nakamura, AJ Martin, OA Bonner, WM AF Redon, Christophe E. Dickey, Jennifer S. Nakamura, Asako J. Martin, Olga A. Bonner, William M. BE DeWeese, TL Laiho, M TI H2AX in DNA Damage Response SO MOLECULAR DETERMINANTS OF RADIATION RESPONSE SE Current Cancer Research LA English DT Article; Book Chapter DE gamma-H2AX foci; Double-strand break repair; Ionizing radiation; Cancer; Clinical applications; Environmental toxins ID DOUBLE-STRAND BREAKS; PHOSPHORYLATED HISTONE H2AX; FIELD GEL-ELECTROPHORESIS; PERIPHERAL-BLOOD LYMPHOCYTES; DOSE-RATE IRRADIATION; GAMMA-H2AX FOCI; ATAXIA-TELANGIECTASIA; CELLULAR SENESCENCE; GENOMIC INSTABILITY; IONIZING-RADIATION AB Histone H2AX is a tumor suppressor, helping to preserve genome integrity. It does this by becoming massively and quickly phosphorylated at the sites of nascent DNA double-strand breaks (DSBs) in chromatin. In this chapter, we discuss the state of current knowledge concerning the various aspects of H2AX metabolism, including DSB formation, H2AX phosphorylation to form foci, foci size, and foci stoichiometry with DSBs. While H2AX is essential for efficient DSB repair, it is not essential for basic DSB repair. Mice lacking H2AX are viable under sterile conditions. However, H2AX plays an essential role in two processes necessary for long-term animal survival: immune system development and male fertility. We discuss the phosphorylation of H2AX during telomere dysfunction, interrupted replication/transcription, virus infection, and apoptosis. Phosphorylated H2AX foci serve as platforms for the recruitment of DNA repair and chromatin remodeling factors as well as factors involved in the cell-cycle checkpoint. Phosphorylated H2AX foci are also useful to detect DSBs related to cancer, senescence, and the radiation-induced bystander effect. We conclude by discussing clinical applications which are also coming to the forefront. These include applications in radiation biodosimetry, individual radiosensitivity, efficiency of chemotherapeutic agents to damage cancer and normal cells, and the evaluation of environmental toxins. C1 [Redon, Christophe E.; Dickey, Jennifer S.; Nakamura, Asako J.; Martin, Olga A.; Bonner, William M.] NCI, Mol Pharmacol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. RP Bonner, WM (reprint author), NCI, Mol Pharmacol Lab, Ctr Canc Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. EM bonnerw@mail.nih.gov NR 180 TC 3 Z9 3 U1 0 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4419-8043-4 J9 CURR CANCER RES PY 2011 BP 3 EP 33 DI 10.1007/978-1-4419-8044-1_1 D2 10.1007/978-1-4419-8044-1 PG 31 WC Oncology SC Oncology GA BUG37 UT WOS:000289213000001 ER PT B AU Wang, XW Grisham, JW Thorgeirsson, SS AF Wang, Xin Wei Grisham, Joe W. Thorgeirsson, Snorri S. BE Wang, XW Grisham, JW Thorgeirsson, SS TI Biology of Hepatocellular Carcinoma: Past, Present and Beyond SO MOLECULAR GENETICS OF LIVER NEOPLASIA SE Cancer Genetics-Series LA English DT Article; Book Chapter DE Primary liver cancer; Hepatocellular carcinoma; Hepatitis B virus; Hepatitis C virus; Aflatoxin; TP53 mutation; Chronic liver disease; Cancer biomarker; Cancer screening; Therapy; Liver transplantation; Alpha fetoprotein; AFP-L3; Tumor staging; Cirrhosis; HCC metastasis; Genetic signature; cDNA microarray; transcriptomics; Hepatocarcinogenesis; Tumor suppressor gene; Oncogene; microRNA; Molecular; Personalized cancer care ID HEPATITIS-B-VIRUS; ABERRANT DNA METHYLATION; GLOBAL CANCER STATISTICS; PRIMARY LIVER-CANCER; MOLECULAR PATHOGENESIS; ALPHA-FETOPROTEIN; TRANSGENIC MICE; ALLELIC LOSSES; UNITED-STATES; BREAST-CANCER AB Primary liver cancer (PLC) is the third most deadly and fifth most common cancer in the world (Parkin et al. 1999), with an estimated 626,000 or 5.7% of new cancer cases and almost as many deaths in 2002 (Parkin et al. 2005). Liver cancer is an ancient disease and its description can be found in Huangdi Neijing, an ancient Chinese medical textbook also known as Yellow Emperor's Inner Canon dated back over 2000 years ago. However, the first mentioned PLC case could be dated as early as 1849 by Carl Rokitansky and the definition of PLC, as referenced to metastatic liver cancer, was only formally established in 1888 by Victor Hanot and Augustin Gilbert, and in 1889 independently by Moriharu Miura (Hanot and Gilbert 1888; Rokitansky 1849; Yamagiwa 1911). Traditionally, PLC was considered as an incurable disease clue to an extremely poor outcome. Patients with PLC have been an underserved population since the. beginning of its discovery and the disease is becoming a major health burden worldwide. Clearly, there is a strong need in expanding basic and translational research on PLC with an ultimate goal to reduce its severity. Recent studies on HCC genetic and genomic analyses feature important advances in the understanding of the complex biological processes underlying tumorigenesis and metastasis of PLC, and demonstrate how these insights might translate into clinical applications. As we approach a golden era in PLC research, we anticipate a significant advance in our understanding of this disease in near future, We are confident that the knowledge gain from continuing research efforts on PLC undoubtedly facilitates the understanding of molecular mechanism and tumor biology to provide the best therapy for each cancer patient and to improve patient management. C1 [Wang, Xin Wei] NCI, Liver Carcinogenesis Sect, Human Carcinogenesis Lab, NIH, Bethesda, MD 20892 USA. [Grisham, Joe W.] Univ N Carolina, Chapel Hill, NC 27599 USA. [Thorgeirsson, Snorri S.] NCI, Ctr Excellence Integrat Canc Biol & Genom Chief, Expt Carcinogenesis Lab, Ctr Canc Res,NIH, Bethesda, MD 20892 USA. RP Wang, XW (reprint author), NCI, Liver Carcinogenesis Sect, Human Carcinogenesis Lab, NIH, 37 Convent Dr,MSC 4258,Bldg 37,Room 3044A, Bethesda, MD 20892 USA. EM xw3u@nih.gov; joe_grisham@med.unc.edu; snorri_thorgeirsson@nih.gov; xw3u@nih.gov; joe_grisham@med.unc.edu; snorri_thorgeirsson@nih.gov NR 95 TC 2 Z9 2 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4419-6081-8 J9 CANCER GENET-SER JI Cancer Genetics PY 2011 BP 3 EP 17 DI 10.1007/978-1-4419-6082-5_1 D2 10.1007/978-1-4419-6082-5 PG 15 WC Oncology; Genetics & Heredity SC Oncology; Genetics & Heredity GA BSJ63 UT WOS:000284723700001 ER PT B AU Grisham, JW Wang, XW Thorgeirsson, SS AF Grisham, Joe W. Wang, Xin Wei Thorgeirsson, Snorri S. BE Wang, XW Grisham, JW Thorgeirsson, SS TI Overview of Cholangiocarcinoma and Evidence for a Primary Liver Carcinoma Spectrum SO MOLECULAR GENETICS OF LIVER NEOPLASIA SE Cancer Genetics-Series LA English DT Article; Book Chapter DE Primary liver cancer; Hepatocellular carcinoma; Intrahepatic cholangiocarcinoma; Overlap of primary liver cancers ID COMBINED HEPATOCELLULAR-CHOLANGIOCARCINOMA; HUMAN INTRAHEPATIC CHOLANGIOCARCINOMA; COMPARATIVE GENOMIC HYBRIDIZATION; PROGENITOR-CELL ORIGIN; BILIARY-TRACT CANCERS; ALBUMIN MESSENGER-RNA; IN-SITU HYBRIDIZATION; WB-F344 RAT-LIVER; HEPATITIS-C; CHOLANGIOCELLULAR CARCINOMA AB Intrahepatic cholangiocarcinoma, second in incidence to hepatocellular carcinoma among the primary liver carcinomas, has an even more dismal prognosis. Intrahepatic cholangiocarcinoma is difficult to diagnose at an early stage of development and advances aggressively, with widespread metastases. Molecular genetic features of intrahepatic cholangiocarcinoma have been partially elucidated, although the specific genetic lesions and molecular processes that drive its development, progression, and metastasis are still obscure. Evidence has accumulated from many sources suggesting that cholangiocarcinoma and hepatocellular carcinoma are components of a spectrum of primary liver carcinomas, including poorly and aberrantly differentiated varieties. Primary liver carcinomas arise from cells in different stages of development that encompass the entire lineage of liver epithelial cells generated from hepatoblasts and/or adult liver stern cells, and share critical genomic aberrations and phenotypes with these progenitor cells. C1 [Grisham, Joe W.] Univ N Carolina, Chapel Hill, NC 27599 USA. [Wang, Xin Wei] NCI, Liver Carcinogenesis Sect, Human Carcinogenesis Lab, NIH, Bethesda, MD 20892 USA. [Thorgeirsson, Snorri S.] NCI, Ctr Excellence Integrat Canc Biol & Genom Chief, Expt Carcinogenesis Lab, Ctr Canc Res,NIH, Bethesda, MD 20892 USA. RP Grisham, JW (reprint author), Univ N Carolina, Chapel Hill, NC 27599 USA. EM joe_grisham@med.unc.edu; xw3u@nih.gov; snorri_thorgeirsson@nih.gov; xw3u@nih.gov; joe_grisham@med.unc.edu; snorri_thorgeirsson@nih.gov NR 95 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4419-6081-8 J9 CANCER GENET-SER JI Cancer Genetics PY 2011 BP 19 EP 33 DI 10.1007/978-1-4419-6082-5_2 D2 10.1007/978-1-4419-6082-5 PG 15 WC Oncology; Genetics & Heredity SC Oncology; Genetics & Heredity GA BSJ63 UT WOS:000284723700002 ER PT B AU Coulouarn, C Thorgeirsson, SS AF Coulouarn, Cedric Thorgeirsson, Snorri S. BE Wang, XW Grisham, JW Thorgeirsson, SS TI Integrative and Functional Genomics of HCC SO MOLECULAR GENETICS OF LIVER NEOPLASIA SE Cancer Genetics-Series LA English DT Article; Book Chapter DE Hepatocellular carcinoma; Gene expression profiling; Comparative-integrative functional genomics; System biology ID HUMAN HEPATOCELLULAR-CARCINOMA; DIFFERENTIAL GENE-EXPRESSION; CDNA MICROARRAY ANALYSIS; HUMAN CANCER; MOUSE MODELS; LIVER-CANCER; HEPATITIS-B; NONALCOHOLIC STEATOHEPATITIS; OLIGONUCLEOTIDE MICROARRAY; THERAPEUTIC TARGETS AB In this chapter, we review the impact of functional and integrative genomics on hepatocellular carcinoma (HCC) research over the last decade. We focus on how genome-wide and high-throughput technologies have been used successfully to classify HCC at a molecular level and became important tools to refine the diagnosis and prognosis predictions of HCC. We also describe how cross-species comparative oncogenomic emerged as a powerful strategy to improve HCC prognostication, as well as to highlight evolutionally conserved regulatory modules or pathways that may be critical in hepatocarcinogenesis. In order to achieve a complete understanding of the molecular mechanisms involved in the disease, the field is now shifting toward integrative genomics, which now combines multi-parametric data reflecting alterations at genomic, genetic and epigenetic levels. Undoubtedly, functional and integrative genomics promise to yield unprecedented biological insights into the pathogenesis of HCC and will ultimately converge toward a personalized medicine that will improve diagnosis, treatment and prevention of liver cancer. C1 [Coulouarn, Cedric] Univ Rennes 1, INSERM, UMR 991, Hop Pontchaillou, F-35033 Rennes, France. [Coulouarn, Cedric] Univ Rennes 1, INSERN, UMR 991, Hop Pontchaillou, F-35033 Rennes, France. [Thorgeirsson, Snorri S.] NCI, Ctr Excellence Integrat Canc Biol & Genom Chief, Expt Carcinogenesis Lab, Ctr Canc Res,NIH, Bethesda, MD 20892 USA. RP Coulouarn, C (reprint author), Univ Rennes 1, INSERM, UMR 991, Hop Pontchaillou, F-35033 Rennes, France. EM cedric.coulouarn@univ-rennes1.fr; snorri_thorgeirsson@nih.gov RI Coulouarn, Cedric/E-5472-2011 NR 68 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4419-6081-8 J9 CANCER GENET-SER JI Cancer Genetics PY 2011 BP 221 EP 240 DI 10.1007/978-1-4419-6082-5_12 D2 10.1007/978-1-4419-6082-5 PG 20 WC Oncology; Genetics & Heredity SC Oncology; Genetics & Heredity GA BSJ63 UT WOS:000284723700012 ER PT S AU Newbold, RR AF Newbold, Retha R. BE Lustig, RH TI Perinatal Exposure to Endocrine Disrupting Chemicals with Estrogenic Activity and the Development of Obesity SO OBESITY BEFORE BIRTH: MATERNAL AND PRENATAL INFLUENCES ON THE OFFSPRING SE Endocrine Updates LA English DT Article; Book Chapter ID EPIGENETIC TRANSGENERATIONAL ACTIONS; IN-UTERO EXPOSURE; BISPHENOL-A; ENVIRONMENTAL ESTROGENS; METABOLIC SYNDROME; ADULT DISEASE; FETAL ORIGINS; CD-1 MICE; DIETHYLSTILBESTROL; EPIDEMIC C1 [Newbold, Retha R.] NIEHS, NIH, Res Triangle Pk, NC 27709 USA. EM newbold1@niehs.nih.gov NR 83 TC 2 Z9 2 U1 0 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 1566-0729 BN 978-1-4419-7033-6 J9 ENDOCR UPDAT PY 2011 BP 367 EP 382 DI 10.1007/978-1-4419-7034-3_18 D2 10.1007/978-1-4419-7034-3 PG 16 WC Endocrinology & Metabolism; Obstetrics & Gynecology SC Endocrinology & Metabolism; Obstetrics & Gynecology GA BRK21 UT WOS:000282900300018 ER PT B AU McTiernan, A Nebeling, L Ballard-Barbash, R AF McTiernan, Anne Nebeling, Linda Ballard-Barbash, Rachel BE McTiernan, A TI Physical Activity, Dietary Calorie Restriction, and Cancer Introduction SO PHYSICAL ACTIVITY, DIETARY CALORIE RESTRICTION, AND CANCER SE Energy Balance and Cancer LA English DT Editorial Material; Book Chapter AB An increasing body of literature has linked overweight, obesity, and a sedentary lifestyle to increased risk for several types of cancers These lifestyle factors have also been associated with prognosis of several types of cancers This volume provides a review of the state of the science on the role of energy balance, physical activity, and cancer incidence and prognosis, as well as mechanisms that may underlie associations of energy balance with cancer risk and prognosis The epidemic of overweight and obesity and the increasing sedentary lifestyles will impact the magnitude and quality of the cancer problem globally Increasing the knowledge of scientists, clinicians, and policy experts will aid in defining new prevention and treatment methods, to reduce the impact of energy balance on cancer, with the goal to eventually reduce the burden of cancer C1 [McTiernan, Anne] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA. [Nebeling, Linda] NCI, Div Canc Control & Populat Sci, Behav Res Program, Bethesda, MD USA. [Ballard-Barbash, Rachel] NCI, Div Canc Control & Populat Sci, Appl Res Program, Bethesda, MD USA. RP McTiernan, A (reprint author), Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4419-7550-8 J9 ENERG BALANCE CANCER JI Energy Balance Canc. PY 2011 VL 3 BP 1 EP 3 DI 10.1007/978-1-4419-7551-5_1 D2 10.1007/978-1-4419-7551-5 PG 3 WC Oncology; Nutrition & Dietetics SC Oncology; Nutrition & Dietetics GA BSP28 UT WOS:000285267100001 ER PT B AU Maley, CC Szabo, E Reid, BJ AF Maley, Carlo C. Szabo, Eva Reid, Brian J. BE Fitzgerald, RC TI Somatic Evolution in Neoplastic Progression and Cancer Prevention SO PRE-INVASIVE DISEASE: PATHOGENESIS AND CLINICAL MANAGEMENT LA English DT Article; Book Chapter ID ACUTE MYELOID-LEUKEMIA; TRANS-RETINOIC ACID; CELL LUNG-CANCER; 2ND PRIMARY TUMORS; GENE AMPLIFICATION; BETA-CAROTENE; INTRAEPITHELIAL NEOPLASIA; COLORECTAL ADENOMA; MULTISTAGE CARCINOGENESIS; ESOPHAGEAL ADENOCARCINOMA AB Cancers develop through a process of somatic evolution Thus, cancer prevention can be viewed as an attempt to change the selective pressures on tissues to either prevent or delay cancer onset. However, chemoprevention efforts have met with mixed success to date. Most of the cancer prevention trials that have failed have been in high risk patients that are either late in progression or have had chronic mutagenic exposures like cigarette smoke We hypothesize that some of these trials fail because they select for clones that are resistant to the intervention and actually benefit those clones by suppressing their competitors. The evolutionary understanding of neoplastic progression leads to a variety of predictions and prescriptions for cancer prevention: We should be measuring the selective impact of our interventions in order to discover and manage the evolution of. resistance Pre-clinical models with extensive intratumor genetic heterogeneity should be developed to better predict clinical outcomes. Resistance is less likely to develop prior to the evolution of genetic and epigenetic instability. We should develop measures of the dynamics of somatic evolution so that we can develop interventions to slow the process of neoplastic progression Multidrug cancer prevention cocktails should be developed that require multiple alterations in order for cells to become resistant to the cocktail. Finally, we should develop cancer prevention interventions with the goal of preventing, channeling of managing somatic evolution. Because somatic evolution is at the heart of neoplastic progression, it must be at the heart of how we manage the disease C1 [Maley, Carlo C.] Wistar Inst Anat & Biol, Mol & Cellular Oncogenesis Program, Philadelphia, PA 19104 USA. [Szabo, Eva] NCI, Lung & Upper Aerodigest Canc Res Grp, Canc Prevent Div, NIH, Bethesda, MD 20892 USA. [Reid, Brian J.] Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA. [Reid, Brian J.] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA. [Reid, Brian J.] Univ Washington, Dept Med, Seattle, WA 98195 USA. [Reid, Brian J.] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA. RP Maley, CC (reprint author), Wistar Inst Anat & Biol, Mol & Cellular Oncogenesis Program, 3600 Spruce St, Philadelphia, PA 19104 USA. NR 88 TC 2 Z9 2 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4419-6693-3 PY 2011 BP 111 EP 127 DI 10.1007/978-1-4419-6694-0_7 D2 10.1007/978-1-4419-6694-0 PG 17 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA BRT38 UT WOS:000283620600007 ER PT B AU Ivy, SP Egorin, MJ Takimoto, CH Wick, JY AF Ivy, S. Percy Egorin, Merrill J. Takimoto, Chris H. Wick, Jeannette Y. BE Hidalgo, M Eckhardt, SG GarrettMayer, E Clendeninn, NJ TI Clinical Trials in Special Populations SO PRINCIPLES OF ANTICANCER DRUG DEVELOPMENT SE Cancer Drug Discovery and Development LA English DT Article; Book Chapter ID GLOMERULAR-FILTRATION-RATE; NATIONAL-CANCER-INSTITUTE; DYSFUNCTION-WORKING-GROUP; IMPAIRED RENAL-FUNCTION; MULTIPLE-MYELOMA PATIENTS; SERUM CYSTATIN-C; CELL LUNG-CANCER; PHASE-I TRIALS; CREATININE CLEARANCE; ELDERLY-PATIENTS C1 [Ivy, S. Percy] NCI, Div Canc Treatment & Diag, Canc Therapy Evaluat Program, Invest Drug Branch, Rockville, MD 20852 USA. [Egorin, Merrill J.] Univ Pittsburgh, Pittsburgh Canc Inst, Pittsburgh, PA 15213 USA. [Takimoto, Chris H.] Ortho Biotech Oncol R&D, Radnork, PA 19087 USA. [Wick, Jeannette Y.] NCI, Canc Therapy Evaluat Program, Pharmaceut Management Branch, Rockville, MD USA. RP Ivy, SP (reprint author), NCI, Div Canc Treatment & Diag, Canc Therapy Evaluat Program, Invest Drug Branch, 6130 Execut Blvd,Suite 7131, Rockville, MD 20852 USA. EM ivyp@ctep.nci.nih.gov; egorinmj@upmc.edu; CTakimot@its.jnj.com; wickj@ctep.nci.nih.gov NR 92 TC 0 Z9 0 U1 0 U2 0 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA BN 978-1-4419-7357-3 J9 CANCER DRUG DISCOV D JI Canc. Drug. Disc. Dev. PY 2011 BP 603 EP 628 DI 10.1007/978-1-4419-7358-0_22 PG 26 WC Oncology; Pharmacology & Pharmacy SC Oncology; Pharmacology & Pharmacy GA BTC93 UT WOS:000286531700022 ER PT B AU Dudley, JP Mertz, JA Bhadra, S Palmarini, M Kozak, CA AF Dudley, Jaquelin P. Mertz, Jennifer A. Bhadra, Sanchita Palmarini, Massimo Kozak, Christine A. BE Dudley, J TI Endogenous Retroviruses and Cancer SO RETROVIRUSES AND INSIGHTS INTO CANCER LA English DT Article; Book Chapter DE Endogenous provirus; Recombination; Host immunity; Pathogenesis; ERVs ID MAMMARY-TUMOR VIRUS; MURINE LEUKEMIA-VIRUS; JAAGSIEKTE SHEEP RETROVIRUS; LONG TERMINAL REPEAT; T-CELL LYMPHOMAS; B LEUKEMOGENIC VIRUS; AVIAN HEMANGIOMA RETROVIRUS; FOCUS-FORMING VIRUSES; ENZOOTIC NASAL TUMOR; HUMAN BREAST-CANCER AB Endogenous retroviruses (ERVs) abound in avian and mammalian genomes, including humans, as a result of germline infections by exogenous retroviruses. Most ERVs are defective for production of infectious virus. The defectiveness of ERVs is generally inversely correlated with the length of their residence in the host germline. These ERVs affect retrovirus-induced disease in a number of ways, including manipulation of the immune response, inhibition or facilitation of entry or other steps of virus replication, or as participants in the generation of infectious pathogenic viruses. Ancient ERVs likely have neutral or beneficial roles for the hosts that carry them. However, multiple examples show that additional pathogenic retroviruses will continue to emerge using ERVs as a source of genetic diversity. C1 [Dudley, Jaquelin P.; Mertz, Jennifer A.; Bhadra, Sanchita] Univ Texas Austin, Sect Mol Genet & Microbiol, Austin, TX 78712 USA. [Dudley, Jaquelin P.; Mertz, Jennifer A.; Bhadra, Sanchita] Univ Texas Austin, Inst Cellular & Mol Biol, Austin, TX 78712 USA. [Dudley, Jaquelin P.] Univ Texas Austin, Inst Cell & Mol Biol, Austin, TX 78712 USA. [Palmarini, Massimo] Univ Glasgow, MRC Univ Glasgow, Inst Infect Immun & Inflammat, Ctr Virus Res,Coll Med Vet & Life Sci, Glasgow G61 1QH, Lanark, Scotland. [Kozak, Christine A.] NIAID, Mol Microbiol Lab, Viral Biol Sect, NIH, Bethesda, MD 20892 USA. RP Dudley, JP (reprint author), Univ Texas Austin, Sect Mol Genet & Microbiol, 1 Univ Stn,A5000, Austin, TX 78712 USA. EM jdudley@uts.cc.utexas.edu; mertzja@gmail.com; sanchitabhadra@yahoo.com; m.palmarini@vet.gla.ac.uk; ckozak@niaid.nih.gov NR 277 TC 3 Z9 3 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-0-387-09580-6 PY 2011 BP 119 EP 162 DI 10.1007/978-0-387-09581-3_5 D2 10.1007/978-0-387-09581-3 PG 44 WC Oncology; Virology SC Oncology; Virology GA BSA42 UT WOS:000284029800005 ER PT B AU Ryall, JG Lynch, GS AF Ryall, James G. Lynch, Gordon S. BE Lynch, GS TI Role of beta-Adrenergic Signalling in Skeletal Muscle Wasting: Implications for Sarcopenia SO SARCOPENIA-AGE-RELATED MUSCLE WASTING AND WEAKNESS: MECHANISMS AND TREATMENTS LA English DT Article; Book Chapter DE beta-adrenoceptor agonist; beta-adrenergic signalling; cardiac muscle; fibre type; G-protein couple receptor; heart; muscle hypertrophy; muscle wasting; skeletal muscle ID PROTEIN-COUPLED RECEPTORS; FOXO TRANSCRIPTION FACTORS; HETEROTRIMERIC G-PROTEINS; GAMMA-SUBUNITS; MESSENGER-RNA; FIBER-TYPE; OLD RATS; MUSCULAR-DYSTROPHY; HEART-FAILURE; KINASE-B AB While the importance of beta-adrenergic signalling in the heart has been well documented for more than half a century and continues to receive significant attention, it is only more recently that we have begun to understand the importance of this signalling pathway in skeletal muscle. There is considerable evidence regarding the stimulation of the beta-adrenergic system with beta-adrenoceptor agonists (beta-agonists) in animals and humans. Although traditionally used for the treatment of bronchospasm, it became apparent that some beta-agonists, such as clenbuterol, had the ability to increase skeletal muscle mass and decrease body fat (Ricks et al. 1984; Beerman et al. 1987). These so-called "repartitioning effects" proved desirable for those working in the livestock industry trying to improve feed efficiency and meat quality (Sillence 2004). Not surprisingly, beta(2)-agonists were soon being used by those engaged in competitive bodybuilding and by other athletes, especially those engaged in strength- and power-related sports (Lynch 2002; Lynch and Ryall 2008). As a consequence of their muscle anabolic actions, the effects of beta-agonist administration on skeletal muscle have been examined in a number of animal models (and in humans) with the hope of discovering therapeutic applications, particularly for muscle wasting conditions including sarcopenia (age-related muscle wasting and associated weakness), cancer cachexia, sepsis, and other forms of metabolic stress, denervation, disuse, inactivity, unloading or microgravity, burns, HIV-acquired immunodeficiency syndrome (AIDS), chronic kidney or heart failure, chronic obstructive pulmonary disease, muscular dystrophies, and other neuromuscular disorders. For many of these conditions, the anabolic properties of beta-agonists have the potential to attenuate (or potentially reverse) the muscle wasting, muscle fibre atrophy, and associated muscle weakness. beta-agonists also have clinical significance for enhancing muscle repair and restoring muscle function after injury or following reconstructive surgery. In addition to having anabolic effects on skeletal muscle, beta-agonists have also been associated with some undesirable side effects, including increased heart rate (tachycardia) and muscle tremor, which have so far limited their therapeutic potential. In this chapter we describe the physiological significance of beta-adrenergic signalling in skeletal muscle and discuss the therapeutic potential of beta-adrenergic stimulation for age-related muscle wasting and weakness. We describe the effects of current beta-agonists on skeletal muscle and identify novel research strategies to minimize the unwanted side-effects associated with systemic beta-adrenergic stimulation. C1 [Lynch, Gordon S.] Univ Melbourne, Dept Physiol, Basic & Clin Myol Lab, Melbourne, Vic 3010, Australia. [Ryall, James G.] Natl Inst Arthrit Musculoskeletal & Skin Dis, Lab Muscle Stem Cells & Gene Regulat, NIH, Bethesda, MD USA. RP Lynch, GS (reprint author), Univ Melbourne, Dept Physiol, Basic & Clin Myol Lab, Melbourne, Vic 3010, Australia. EM ryallj@mail.nih.gov; gsl@unimelb.edu.au RI Lynch, Gordon/G-9553-2015 OI Lynch, Gordon/0000-0001-9220-9810 NR 142 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY BN 978-90-481-9712-5 PY 2011 BP 449 EP 471 DI 10.1007/978-90-481-9713-2_19 D2 10.1007/978-90-481-9713-2 PG 23 WC Geriatrics & Gerontology; Sport Sciences SC Geriatrics & Gerontology; Sport Sciences GA BSR26 UT WOS:000285535100019 ER PT S AU Steven, AC Cardone, G Butan, C Winkler, DC Heymann, JB AF Steven, Alasdair C. Cardone, Giovanni Butan, Carmen Winkler, Dennis C. Heymann, J. Bernard BE AgbandjeMckenna, M McKenna, R TI Three-dimensional Structures of Pleiomorphic Viruses from Cryo-Electron Tomography SO STRUCTURAL VIROLOGY SE RSC Biomolecular Sciences LA English DT Article; Book Chapter ID HERPES-SIMPLEX-VIRUS; RECEPTOR-MEMBRANE COMPLEX; TO-NOISE RATIO; ELECTRON TOMOGRAPHY; INFLUENZA-VIRUS; RESOLUTION CRITERION; CRYSTAL-STRUCTURE; HIV-1 VIRIONS; TILT SERIES; CA PROTEIN C1 [Steven, Alasdair C.; Cardone, Giovanni; Butan, Carmen; Winkler, Dennis C.; Heymann, J. Bernard] NIAMSD, Struct Biol Lab, NIH, Bethesda, MD 20892 USA. RP Steven, AC (reprint author), NIAMSD, Struct Biol Lab, NIH, Bethesda, MD 20892 USA. NR 76 TC 3 Z9 3 U1 0 U2 1 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, CAMBRIDGE CB4 4WF, CAMBS, ENGLAND SN 1757-7152 BN 978-0-85404-171-8 J9 RSC BIOMOL SCI JI RSC Biomol. Sci. PY 2011 IS 21 BP 62 EP 80 PG 19 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA BSV57 UT WOS:000285938100004 ER PT S AU Chen, K Tjandra, N AF Chen, Kang Tjandra, Nico BE AgbandjeMckenna, M McKenna, R TI Solution NMR Spectroscopy in Characterizing Structure, Dynamics and Intermolecular Interactions of Retroviral Structural Proteins SO STRUCTURAL VIROLOGY SE RSC Biomolecular Sciences LA English DT Article; Book Chapter ID HUMAN-IMMUNODEFICIENCY-VIRUS; NUCLEAR-MAGNETIC-RESONANCE; MULTIDIMENSIONAL HETERONUCLEAR NMR; HIV-1 NUCLEOCAPSID PROTEIN; HUMAN CYCLOPHILIN-A; CAPSID PROTEIN; DIPOLAR COUPLINGS; BIOLOGICAL MACROMOLECULES; MATRIX PROTEIN; BIOMOLECULAR NMR C1 [Chen, Kang; Tjandra, Nico] NHLBI, Lab Mol Biophys, NIH, Bethesda, MD 20892 USA. RP Chen, K (reprint author), NHLBI, Lab Mol Biophys, NIH, Bldg 10, Bethesda, MD 20892 USA. NR 68 TC 0 Z9 0 U1 0 U2 1 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, CAMBRIDGE CB4 4WF, CAMBS, ENGLAND SN 1757-7152 BN 978-0-85404-171-8 J9 RSC BIOMOL SCI JI RSC Biomol. Sci. PY 2011 IS 21 BP 135 EP 159 PG 25 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA BSV57 UT WOS:000285938100008 ER PT S AU Schowalter, RM Smith, EC Dutch, RE AF Schowalter, Rachel M. Smith, Everett C. Dutch, Rebecca Ellis BE AgbandjeMckenna, M McKenna, R TI Attachment and Entry: Viral Cell Fusion SO STRUCTURAL VIROLOGY SE RSC Biomolecular Sciences LA English DT Article; Book Chapter ID SEMLIKI-FOREST-VIRUS; VESICULAR STOMATITIS-VIRUS; RESPIRATORY SYNCYTIAL VIRUS; BORNE ENCEPHALITIS-VIRUS; METAPNEUMOVIRUS-F-PROTEIN; MEMBRANE-FUSION; LOW-PH; ENVELOPE GLYCOPROTEIN; PARAMYXOVIRUS FUSION; EBOLA-VIRUS C1 [Schowalter, Rachel M.] NCI, Cellular Oncol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. [Smith, Everett C.; Dutch, Rebecca Ellis] Univ Kentucky, Coll Med, Dept Mol & Cellular Biochem, Lexington, KY 40536 USA. RP Schowalter, RM (reprint author), NCI, Cellular Oncol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. NR 92 TC 2 Z9 2 U1 0 U2 1 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, CAMBRIDGE CB4 4WF, CAMBS, ENGLAND SN 1757-7152 BN 978-0-85404-171-8 J9 RSC BIOMOL SCI JI RSC Biomol. Sci. PY 2011 IS 21 BP 243 EP 260 PG 18 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA BSV57 UT WOS:000285938100013 ER PT B AU Parchment, RE AF Parchment, Ralph E. BE Teicher, BA TI Bone Marrow as a Critical Normal Tissue that Limits Drug Dose/Exposure in Preclinical Models and the Clinic SO TUMOR MODELS IN CANCER RESEARCH, SECOND EDITION SE Cancer Drug Discovery and Development LA English DT Article; Book Chapter DE Bone marrow; Hematopoiesis; Progenitor; Stem cell; Hematotoxicology; Neutropenia; Myelosuppression; Dose limiting toxicity; Adverse drug effect; Therapeutic index; Maximum tolerated dose; Prediction models; CFU GM; Engraftment ID HEMATOPOIETIC PROGENITOR CELLS; COLONY-FORMING CELLS; UMBILICAL-CORD BLOOD; SCID IL2R-GAMMA(NULL) MICE; SOLID TUMOR XENOGRAFTS; VIVO CULTURE-SYSTEM; CFU-GM ASSAY; IN-VIVO; PRECURSOR CELLS; STEM-CELLS AB Mouse models of cancer have played an important role in the discovery and development of cytotoxic and targeted anticancer agents Initially discovery models used transplantable syngeneic tumors that were treated with doses maximally tolerated by the normal tissues of the mouse Thus experimental compounds were selected for development based on their selectivity for murine malignant tissue over murine normal tissue and the discovery method assumed that a murine therapeutic Index closely approximates a human therapeutic index for most compounds When mouse modeling migrated to the use of xenografted human malignancies in order that drug efficacy assessment would be more relevant for clinical disease there was not a corresponding transition to human normal tissue to determine the maximum tolerated dose (MTD) to use in treating the mouse Consequently drug discovery in these models has been based on selectivity for human malignant tissue over murine normal tissue This xeno therapeutic index has an unknown relationship either to a mouse or human therapeutic index these latter ones being determined by efficacy against cancer at the maximum dose tolerated by normal tissues from the same species of origin as the cancer The biological process of producing new blood cells is termed hematopoiesis and this process is a frequent target of toxicity of anticancer drugs including toxicity that limits dose Two recently established methods in experimental hematology and hematotoxicology are useful for deter mining the MTD of human hematopoiesis in the mouse The methods are suitable for implementation in the drug discovery setting and therefore could be used to discover new anticancer compounds that exhibit selectivity for malignant human tissue over normal human hematopoiesis in mouse models This chapter provides background information on hematopoiesis explains why it frequently limits the dose of anticancer drugs describes the two methods and then proposes ways in which the methods might contribute to mouse modeling of cancer therapy to improve predictive accuracy for clinical outcome C1 NCI, Lab Human Toxicol & Pharmacol, SA1C Frederick Inc, Frederick, MD 21702 USA. RP Parchment, RE (reprint author), NCI, Lab Human Toxicol & Pharmacol, SA1C Frederick Inc, Frederick, MD 21702 USA. NR 99 TC 0 Z9 0 U1 0 U2 0 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA BN 978-1-60761-967-3 J9 CANCER DRUG DISCOV D JI Canc. Drug. Disc. Dev. PY 2011 BP 521 EP 552 DI 10.1007/978-1-60761-968-0_21 D2 10.1007/978-1-60761-968-0 PG 32 WC Oncology; Pharmacology & Pharmacy SC Oncology; Pharmacology & Pharmacy GA BSV70 UT WOS:000285939500021 ER PT S AU Kim, YS Pobezinskaya, Y Choksi, S Morgan, M Li, T Liu, CY Liu, ZG AF Kim, You-Sun Pobezinskaya, Yelena Choksi, Swati Morgan, Michael Li, Tao Liu, Chengyu Liu, Zhenggang BE Wallach, D Kovalenko, A Feldman, M TI THE FUNCTION OF TRADD IN SIGNALING THROUGH TUMOR NECROSIS FACTOR RECEPTOR 1 AND TRIF-DEPENDENT TOLL-LIKE RECEPTORS SO ADVANCES IN TNF FAMILY RESEARCH SE Advances in Experimental Medicine and Biology LA English DT Meeting Abstract CT 12th Biennial International TNF Conference CY APR, 2009 CL San Lorenzo del Escorial, SPAIN C1 [Kim, You-Sun; Pobezinskaya, Yelena; Choksi, Swati; Morgan, Michael; Li, Tao; Liu, Zhenggang] NCI, Cell & Canc Biol Branch, Ctr Canc Res, Bethesda, MD 20892 USA. [Liu, Chengyu] NHLBI, Transgen Core Facil, NIH, Bethesda, MD 20892 USA. [Kim, You-Sun] Ajou Univ, Sch Med, Inst Med Sci, Suwon 443421, South Korea. NR 0 TC 0 Z9 0 U1 6 U2 7 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0065-2598 BN 978-1-4419-6611-7 J9 ADV EXP MED BIOL JI Adv.Exp.Med.Biol. PY 2011 VL 691 BP 675 EP 675 PG 1 WC Biochemistry & Molecular Biology; Biology; Immunology; Medicine, Research & Experimental SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Immunology; Research & Experimental Medicine GA BVG74 UT WOS:000291501300113 ER PT S AU Siegel, RM Song, YJ Fuss, I Davidson, T Shevach, E Wang, E Meylan, F AF Siegel, Richard M. Song, Yun-Jeong Fuss, Ivan Davidson, Todd Shevach, Ethan Wang, Eddie Meylan, Francoise BE Wallach, D Kovalenko, A Feldman, M TI TL1A-DR3 INTERACTIONS IN T-CELL MEDIATED AUTOIMMUNITY SO ADVANCES IN TNF FAMILY RESEARCH SE Advances in Experimental Medicine and Biology LA English DT Meeting Abstract CT 12th Biennial International TNF Conference CY APR, 2009 CL San Lorenzo del Escorial, SPAIN C1 [Siegel, Richard M.; Song, Yun-Jeong; Meylan, Francoise] NIAMS, Immunoregulat Grp, Autoimmun Branch, Bethesda, MD 20892 USA. [Fuss, Ivan] NIAID, Mucosal Immunol Sect, LICID, Bethesda, MD 20892 USA. [Davidson, Todd; Shevach, Ethan] NIAID, Cellular Immunol Sect, NIH, Bethesda, MD 20892 USA. [Wang, Eddie] Cardiff Univ, Cardiff, S Glam, Wales. NR 0 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0065-2598 BN 978-1-4419-6611-7 J9 ADV EXP MED BIOL JI Adv.Exp.Med.Biol. PY 2011 VL 691 BP 683 EP 684 PG 2 WC Biochemistry & Molecular Biology; Biology; Immunology; Medicine, Research & Experimental SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Immunology; Research & Experimental Medicine GA BVG74 UT WOS:000291501300122 ER PT S AU Griessl, S Chen, X Oppenheim, JJ Mannel, DN AF Griessl, S. Chen, X. Oppenheim, J. J. Maennel, D. N. BE Wallach, D Kovalenko, A Feldman, M TI THE DUAL ROLE OF TNF ON T CELL ACTIVATION SO ADVANCES IN TNF FAMILY RESEARCH SE Advances in Experimental Medicine and Biology LA English DT Meeting Abstract CT 12th Biennial International TNF Conference CY APR, 2009 CL San Lorenzo del Escorial, SPAIN C1 Univ Regensburg, Inst Immunol, D-8400 Regensburg, Germany. NCI Frederick, Immunoregulat Lab, Frederick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0065-2598 BN 978-1-4419-6611-7 J9 ADV EXP MED BIOL JI Adv.Exp.Med.Biol. PY 2011 VL 691 BP 692 EP 693 PG 2 WC Biochemistry & Molecular Biology; Biology; Immunology; Medicine, Research & Experimental SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Immunology; Research & Experimental Medicine GA BVG74 UT WOS:000291501300133 ER PT S AU Yin, Q Lin, SC Lamothe, B Lu, M Lo, YC Hura, G Zheng, LX Rich, RL Campos, AD Myszka, DG Lenardo, MJ Darnay, BG Wu, H AF Yin, Qian Lin, Su-Chang Lamothe, Betty Lu, Miao Lo, Yu-Chih Hura, Gregory Zheng, Lixin Rich, Rebecca L. Campos, Alejandro D. Myszka, David G. Lenardo, Michael J. Darnay, Bryant G. Wu, Hao BE Wallach, D Kovalenko, A Feldman, M TI CRYSTAL STRUCTURE OF TRAF6 REVEALS SPECIFICITY AND MECHANISM OF TRAF6-MEDIATED UBIQUITINATION SO ADVANCES IN TNF FAMILY RESEARCH SE Advances in Experimental Medicine and Biology LA English DT Meeting Abstract CT 12th Biennial International TNF Conference CY APR, 2009 CL San Lorenzo del Escorial, SPAIN C1 [Yin, Qian; Lin, Su-Chang; Lo, Yu-Chih; Wu, Hao] Cornell Univ, Weill Med Coll, New York, NY 10021 USA. [Yin, Qian; Wu, Hao] Tri Inst Training Program Chem Biol, New York, NY 10021 USA. [Lamothe, Betty; Campos, Alejandro D.; Darnay, Bryant G.] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA. [Lu, Miao; Hura, Gregory] Univ Calif Berkeley, Lawrence Berkeley Lab, Adv Light Source, Berkeley, CA 94720 USA. [Zheng, Lixin; Lenardo, Michael J.] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA. [Rich, Rebecca L.; Myszka, David G.] Univ Utah, Sch Med, Ctr Biomol Interact Anal, Salt Lake City, UT 84132 USA. EM haowu@med.cornell.edu NR 0 TC 0 Z9 0 U1 0 U2 3 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0065-2598 BN 978-1-4419-6611-7 J9 ADV EXP MED BIOL JI Adv.Exp.Med.Biol. PY 2011 VL 691 BP 699 EP 700 PG 2 WC Biochemistry & Molecular Biology; Biology; Immunology; Medicine, Research & Experimental SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Immunology; Research & Experimental Medicine GA BVG74 UT WOS:000291501300142 ER PT S AU Cleland, S Nikolov, NP Shimizu, M Bailey, D Aoki, J Strom, T Schwartzberg, PL Candotti, F Siegel, RM AF Cleland, Sophia Nikolov, Nikolay P. Shimizu, Masaki Bailey, Daniel Aoki, Joseph Strom, Ted Schwartzberg, Pamela L. Candotti, Fabio Siegel, Richard M. BE Wallach, D Kovalenko, A Feldman, M TI FAS LIGAND SECRETION AND SELF-TOLERANCE IS REGULATED BY THE WISKOTT-ALDRICH SYNDROME PROTEIN SO ADVANCES IN TNF FAMILY RESEARCH SE Advances in Experimental Medicine and Biology LA English DT Meeting Abstract CT 12th Biennial International TNF Conference CY APR, 2009 CL San Lorenzo del Escorial, SPAIN C1 [Nikolov, Nikolay P.] NIAMS, Off Clin Director, NIH, Bethesda, MD USA. [Shimizu, Masaki; Candotti, Fabio] NHGRI, Disorders Immun Sect, GMBB, NIH, Bethesda, MD 20892 USA. [Aoki, Joseph; Schwartzberg, Pamela L.] NHGRI, Cell Signaling Sect, Genet Dis Res Branch, NIH, Bethesda, MD 20892 USA. [Strom, Ted] Univ Tennessee, Ctr Hlth Sci, Dept Pathol, Memphis, TN 38163 USA. [Cleland, Sophia; Nikolov, Nikolay P.; Bailey, Daniel; Siegel, Richard M.] NIAMS, Immunoregulat Grp, Autoimmun Branch, NIH, Bethesda, MD USA. [Cleland, Sophia] George Washington Univ, Dept Immunol, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0065-2598 BN 978-1-4419-6611-7 J9 ADV EXP MED BIOL JI Adv.Exp.Med.Biol. PY 2011 VL 691 BP 739 EP 740 PG 2 WC Biochemistry & Molecular Biology; Biology; Immunology; Medicine, Research & Experimental SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Immunology; Research & Experimental Medicine GA BVG74 UT WOS:000291501300190 ER PT S AU Chiodoni, C Sangaletti, S Salcedo, R Tripodo, C Ratti, C Gyulai, Z Nedospasov, S Trinchieri, G Colombo, MP AF Chiodoni, Claudia Sangaletti, Sabina Salcedo, Rosalba Tripodo, Claudio Ratti, Chiara Gyulai, Zsofia Nedospasov, Sergei Trinchieri, Giorgio Colombo, Mario P. BE Wallach, D Kovalenko, A Feldman, M TI LEUKOCYTE-DERIVED TNF-alpha PROMOTES TUMOR GROWTH IN A SPONTANEOUS MODEL OF MAMMARY CARCINOGENESIS SO ADVANCES IN TNF FAMILY RESEARCH SE Advances in Experimental Medicine and Biology LA English DT Meeting Abstract CT 12th Biennial International TNF Conference CY APR, 2009 CL San Lorenzo del Escorial, SPAIN C1 [Chiodoni, Claudia; Sangaletti, Sabina; Ratti, Chiara; Colombo, Mario P.] Fdn IRCCS Ist Nazl Tumori, Immunotherapy & Gene Therapy Unit, Dept Expt Oncol, I-20133 Milan, Italy. [Salcedo, Rosalba; Gyulai, Zsofia; Trinchieri, Giorgio] NCI, Canc & Inflammat Program, Ctr Canc Res, Frederick, MD 21702 USA. [Tripodo, Claudio] Univ Palermo, Dipartimento Patol Umana, Palermo, Italy. [Nedospasov, Sergei] Russian Acad Sci, Lab Mol Immunol, VA Engelhardt Mol Biol Inst, Moscow 119991, Russia. EM sergei.nedospasov@gmail.com RI Nedospasov, Sergei/J-5936-2013; Nedospasov, Sergei/L-1990-2015; Tripodo, Claudio/O-4536-2016; Nedospasov, Sergei/Q-7319-2016 OI Tripodo, Claudio/0000-0002-0821-6231; NR 0 TC 0 Z9 0 U1 0 U2 3 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0065-2598 BN 978-1-4419-6611-7 J9 ADV EXP MED BIOL JI Adv.Exp.Med.Biol. PY 2011 VL 691 BP 754 EP 755 PG 2 WC Biochemistry & Molecular Biology; Biology; Immunology; Medicine, Research & Experimental SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Immunology; Research & Experimental Medicine GA BVG74 UT WOS:000291501300207 ER PT S AU McCarthy, DD Ivanov, II Tumanov, AV Shi, H Koroleva, EP Summers-DeLuca, L Ward, LA Casellas, R Nedospovav, SA Fu, YX Littman, DR Gommerman, JL AF McCarthy, Douglas D. Ivanov, Ivaylo I. Tumanov, Alexei V. Shi, Hang Koroleva, Ekaterina P. Summers-deLuca, Leslie Ward, Lesley A. Casellas, Rafael Nedospovav, Sergei A. Fu, Yang-Xin Littman, Dan R. Gommerman, Jennifer L. BE Wallach, D Kovalenko, A Feldman, M TI LYMPHOTOXIN-beta RECEPTOR SIGNALING SUPPORTS A UNIQUE STROMAL CELL NICHE THAT SUPPORTS IGA CLASS SWITCH RECOMBINATION IN THE INTESTINAL LAMINA PROPRIA SO ADVANCES IN TNF FAMILY RESEARCH SE Advances in Experimental Medicine and Biology LA English DT Meeting Abstract CT 12th Biennial International TNF Conference CY APR, 2009 CL San Lorenzo del Escorial, SPAIN C1 [McCarthy, Douglas D.; Shi, Hang; Summers-deLuca, Leslie; Ward, Lesley A.; Gommerman, Jennifer L.] Univ Toronto, Dept Immunol, Toronto, ON M5S 1A8, Canada. [Ivanov, Ivaylo I.; Littman, Dan R.] NYU, Sch Med, Kimmel Ctr Biol & Med, Skirball Inst, New York, NY 10016 USA. [Littman, Dan R.] NYU, Sch Med, Howard Hughes Med Inst, Dept Microbiol, New York, NY 10016 USA. [Littman, Dan R.] NYU, Sch Med, Howard Hughes Med Inst, Dept Pathol, New York, NY 10016 USA. [Tumanov, Alexei V.; Koroleva, Ekaterina P.; Fu, Yang-Xin] Univ Chicago, Dept Pathol & Immunol, Chicago, IL 60636 USA. [Casellas, Rafael] NIAMSD, NIH, Bethesda, MD 20892 USA. [Nedospovav, Sergei A.] Russian Acad Sci, Engelhardt Inst Mol Biol, Lab Mol Immunol, Moscow 119991, Russia. EM sergei.nedospasov@gmail.com; jen.gommerman@utoronto.ca NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0065-2598 BN 978-1-4419-6611-7 J9 ADV EXP MED BIOL JI Adv.Exp.Med.Biol. PY 2011 VL 691 BP 776 EP 776 PG 1 WC Biochemistry & Molecular Biology; Biology; Immunology; Medicine, Research & Experimental SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Immunology; Research & Experimental Medicine GA BVG74 UT WOS:000291501300232 ER PT J AU Leopold, DA AF Leopold, David A. TI What is it like to be a human? SO COGNITIVE NEUROSCIENCE LA English DT Editorial Material AB The explicit link between awareness and sociality put forward in the accompanying article opens new doors to thinking about the evolutionary origins of consciousness. Human subjective experience undoubtedly has some features that are species-specific and others that are shared over a broad phylogenetic base. The authors' proposal that consciousness depends on high-level neural circuits evolved for social perception begs the question whether animals lacking such circuitry experience a fundamentally different form of consciousness from humans. It also highlights the need for comparative work elucidating neural mechanisms by which animals other than primates perceive and respond to their conspecifics. C1 NIMH, Unit Cognit Neurophysiol & Imaging, NIH, Bethesda, MD 20892 USA. RP Leopold, DA (reprint author), NIMH, Unit Cognit Neurophysiol & Imaging, NIH, Bethesda, MD 20892 USA. EM leopoldd@mail.nih.gov OI Leopold, David/0000-0002-1345-6360 FU Intramural NIH HHS [ZIA MH002838-07] NR 0 TC 0 Z9 0 U1 0 U2 1 PU PSYCHOLOGY PRESS PI HOVE PA 27 CHURCH RD, HOVE BN3 2FA, EAST SUSSEX, ENGLAND SN 1758-8928 J9 COGN NEUROSCI-UK JI Cogn. Neurosci PY 2011 VL 2 IS 2 BP 121 EP 122 AR PII 938734921 DI 10.1080/17588928.2011.585235 PG 2 WC Neurosciences SC Neurosciences & Neurology GA 779UO UT WOS:000291807900013 PM 22081774 ER PT B AU Robbins, JB Schneerson, R Szu, SC Pozsgay, V AF Robbins, John B. Schneerson, Rachel Szu, Shouson C. Pozsgay, Vince BE Plotkin, SA TI Polysaccharide-Protein Conjugate Vaccines SO HISTORY OF VACCINE DEVELOPMENT LA English DT Article; Book Chapter ID INFLUENZAE TYPE-B; SHIGELLA-DYSENTERIAE TYPE-1; O-SPECIFIC POLYSACCHARIDE; HEMOPHILUS-INFLUENZAE; CAPSULAR POLYSACCHARIDE; ANTIBODY-RESPONSES; IMMUNOLOGICAL RESPONSES; SALMONELLA-TYPHIMURIUM; HUMAN IMMUNITY; AGE INCIDENCE C1 [Robbins, John B.; Schneerson, Rachel; Szu, Shouson C.; Pozsgay, Vince] NICHHD, NIH, Bethesda, MD 20892 USA. RP Robbins, JB (reprint author), NICHHD, NIH, Bethesda, MD 20892 USA. EM robbinsjo@mail.nib.gov NR 66 TC 0 Z9 1 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4419-1338-8 PY 2011 BP 91 EP 102 DI 10.1007/978-1-4419-1339-5_12 D2 10.1007/978-1-4419-1339-5 PG 12 WC Immunology SC Immunology GA BVF18 UT WOS:000291365000012 ER PT J AU Xu, XH Xu, MM Jones, OD Chen, XZ Li, YF Yan, GF Pan, YX Davis, HG Xu, Y Bryant, JL Zheng, SE Anthony, DD AF Xu, Xuehong Xu, Mengmeng Jones, Odell D. Chen, Xunzhang Li Yanfei Yan, Guifang Pan, Yuexing Davis, Harry G. Xu, Yi Bryant, Joseph L. Zheng, Shangen Anthony, Donald D. TI Liquid Crystal in Lung Development and Chicken Embryogenesis SO MOLECULAR CRYSTALS AND LIQUID CRYSTALS LA English DT Article DE Embryogenesis; liquid crystal droplet; lung development; phase transition ID LIPOID DROPLETS; RECEPTOR; FIBROBLASTS AB Organogenesis has been given increasing attention in the fields of biomedical and bioengineering. However, the mechanism for a succession process as complex as embryogenesis remains largely unknown. Based on our previous discoveries, liquid crystal may play a crucial role in organogenesis. Here, our results demonstrated that LC droplets were distributed on the pleural area, the bronchus and bronchiole in the developing lung. The lung liquid crystal droplets are capable of phase transitions between liquid crystal, crystal, and isotropic phases which are dependent on the rate of temperature change as previously reported in liver, kidney and other major tissues of the embryo. C1 [Xu, Xuehong; Chen, Xunzhang; Li Yanfei] Univ Maryland, Sch Med, Ctr Biomed & Engn Technol, Dept Physiol, Baltimore, MD 21201 USA. [Xu, Xuehong] Wuhan Univ, Sch Life Sci, Wuhan 430072, Peoples R China. [Xu, Mengmeng] Univ Maryland, Dept Chem & Biochem, Gemstone Program, College Pk, MD 20742 USA. [Xu, Mengmeng] Johns Hopkins Univ Hosp, Sch Med, Dept Pathol, Baltimore, MD 21205 USA. [Jones, Odell D.; Davis, Harry G.; Bryant, Joseph L.] Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA. [Chen, Xunzhang; Li Yanfei; Zheng, Shangen] Gen Hosp, Wuhan, Peoples R China. [Yan, Guifang] Johns Hopkins Univ Hosp, Sch Med, Dept Urol, Baltimore, MD 21205 USA. [Pan, Yuexing; Anthony, Donald D.] Case Western Reserve Univ, Inst Pathol, Cleveland, OH 44106 USA. [Xu, Yi] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Detroit, MI USA. RP Xu, XH (reprint author), Univ Maryland, Sch Med, Ctr Biomed & Engn Technol, Dept Physiol, Baltimore, MD 21201 USA. EM xxu@umarylamd.edu NR 35 TC 2 Z9 2 U1 0 U2 0 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1542-1406 J9 MOL CRYST LIQ CRYST JI Mol. Cryst. Liquid Cryst. PY 2011 VL 547 SI SI BP 164 EP 172 AR PII 938730031 DI 10.1080/15421406.2011.572042 PG 9 WC Crystallography SC Crystallography GA 780MN UT WOS:000291861400020 ER PT J AU Xu, MM Jones, OD Zheng, SE Li, YF Yan, GF Pan, YX Davis, HG Anthony, DD Xu, Y Bryant, JL Xu, XH AF Xu, Mengmeng Jones, Odell D. Zheng, Shangen Li Yanfei Yan, Guifang Pan, Yuexing Davis, Harry G. Anthony, Donald D. Xu, Yi Bryant, Joseph L. Xu, Xuehong TI Cytoplasmic Accumulation of Liquid-Crystal Like Droplets in Post-Infection Sputum Generated by Gram-Positive Bacteria SO MOLECULAR CRYSTALS AND LIQUID CRYSTALS LA English DT Article DE Gram-positive sputum; liquid-crystal like droplets; monocyte; squamous epithelial cell ID ANDERSON-FABRY-DISEASE; MACULAR DEGENERATION; FIBROBLASTS; RECEPTOR; VARIANT AB Massive liquid crystal droplets (LCDs) have been reported in early embryogenesis and implicated in pathological progression of human diseases. The presence of LCDs has even been established as an effective diagnostic hallmark of Fabry-Anderson's disease. In this study, we report the presence of LCDs, identified by established thermal stage phase transition methods, in sputum collected during the recovery phase of respiratory infection by gram-positive bacteria. This finding provides additional insight on the breadth of liquid crystal presence in human pathology. Further study on the formation of these LCDs may lead to new perspectives on post-infection removal of infectious agents. C1 [Li Yanfei; Xu, Xuehong] Univ Maryland, Sch Med, Dept Physiol, Ctr Biomed & Engn Technol, Baltimore, MD 21201 USA. [Xu, Mengmeng] Duke Univ, Sch Med, MSTP Program, Durham, NC USA. [Xu, Mengmeng] Johns Hopkins Univ Hosp, Sch Med, Dept Pathol, Baltimore, MD 21205 USA. [Jones, Odell D.; Davis, Harry G.; Bryant, Joseph L.] Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA. [Zheng, Shangen; Li Yanfei] Gen Hosp, Wuhan, Peoples R China. [Yan, Guifang] Johns Hopkins Univ Hosp, Sch Med, Dept Urol, Baltimore, MD 21205 USA. [Pan, Yuexing; Anthony, Donald D.] Case Western Reserve Univ, Inst Pathol, Cleveland, OH 44106 USA. [Xu, Yi] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Detroit, MI USA. [Xu, Xuehong] Wuhan Univ, Sch Life Sci, Wuhan 430072, Peoples R China. RP Xu, XH (reprint author), Univ Maryland, Sch Med, Dept Physiol, Ctr Biomed & Engn Technol, Baltimore, MD 21201 USA. EM xxu@umarylamd.edu FU TEDCO MD Stem Cell Research Fund; American Heart Association FX This work is supported by the TEDCO MD Stem Cell Research Fund and American Heart Association. NR 23 TC 2 Z9 2 U1 0 U2 0 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1542-1406 J9 MOL CRYST LIQ CRYST JI Mol. Cryst. Liquid Cryst. PY 2011 VL 547 SI SI BP 173 EP 180 AR PII 938726675 DI 10.1080/15421406.2011.572045 PG 8 WC Crystallography SC Crystallography GA 780MN UT WOS:000291861400021 ER PT J AU Cao, JJ Prisinzano, TE Okunola, OM Kopajtic, T Shook, M Katz, JL Newman, AH AF Cao, Jianjing Prisinzano, Thomas E. Okunola, Oluyomi M. Kopajtic, Theresa Shook, Matthew Katz, Jonathan L. Newman, Amy Hauck TI SARs at the Monoamine Transporters for a Novel Series of Modafinil Analogues SO ACS MEDICINAL CHEMISTRY LETTERS LA English DT Article DE SAR; monoamine transporters; modafinil analogues ID DOPAMINE UPTAKE INHIBITORS; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; IN-VIVO; COCAINE; ARMODAFINIL; DEPENDENCE; COGNITION; POTENT AB A series of modafinil (1) analogues were synthesized wherein (1) para-halo substitutents were added to the aryl rings, (2) the sulfoxide function was removed, and (3) the primary amide group was replaced with secondary and tertiary amides and amines to investigate the effects of these chemical modifications on dopamine transporter, serotonin transporter, and norepinephrine transporter binding. In addition, the locomoter-stimulant effects in mice of (+/-) modafinil (1), its R- and S-enantiomers, and its para-chloro sulfinylacetamide analogue (5c) were compared to those of cocaine. C1 [Cao, Jianjing; Okunola, Oluyomi M.; Newman, Amy Hauck] NIDA, Med Chem Sect, Intramural Res Program, NIH, Baltimore, MD 21224 USA. [Kopajtic, Theresa; Shook, Matthew; Katz, Jonathan L.] NIDA, Psychobiol Sect, Intramural Res Program, NIH, Baltimore, MD 21224 USA. [Prisinzano, Thomas E.] Univ Kansas, Dept Med Chem, Lawrence, KS 66045 USA. RP Newman, AH (reprint author), NIDA, Med Chem Sect, Intramural Res Program, NIH, 333 Cassell Dr, Baltimore, MD 21224 USA. EM anewman@intra.nida.nih.gov OI Katz, Jonathan/0000-0002-1068-1159 FU NIDA-IRP; NIH FX This work was funded by the NIDA-IRP. O.M.O. was supported by a NIH Postdoctoral Intramural Research Training Award (IRTA) Fellowship. M.S. was supported by the NIH Summer Internship Program. NR 30 TC 16 Z9 17 U1 5 U2 8 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1948-5875 J9 ACS MED CHEM LETT JI ACS Med. Chem. Lett. PD JAN PY 2011 VL 2 IS 1 BP 48 EP 52 DI 10.1021/ml1002025 PG 5 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 707SL UT WOS:000286306200010 PM 21344069 ER PT J AU Greene, MH Mai, PL Schwartz, PE AF Greene, Mark H. Mai, Phuong L. Schwartz, Peter E. TI Does bilateral salpingectomy with ovarian retention warrant consideration as a temporary bridge to risk-reducing bilateral oophorectomy in BRCA1/2 mutation carriers? SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article DE bilateral oophorectomy; bilateral salpingectomy; BRCA1/2 mutation carrier; ovarian cancer risk; risk-reducing surgery ID PELVIC SEROUS CARCINOMA; PROPHYLACTIC OOPHORECTOMY; CANCER RISK; BREAST-CANCER; FALLOPIAN-TUBE; FOLLOW-UP; INTRAEPITHELIAL CARCINOMA; PATHOLOGICAL FINDINGS; TALC-USE; WOMEN AB Risk-reducing salpingo-oophorectomy (RRSO) is the most definitive surgical intervention for ovarian cancer risk reduction among BRCA1/2 mutation carriers. For women who have completed child-bearing but who are not ready for RRSO, bilateral salpingectomy with ovarian retention (BSOR) might serve as a temporary measure while definitive risk-reducing surgery is being contemplated. Here we summarize recent insights into the pathogenesis of hereditary ovarian cancer that might provide a basis for consideration of the proposed BSOR management strategy and outline the evidence for and against this potential risk-reducing intervention. Based on the evidence, we suggest that there may be sufficient merit in this proposed intervention to consider evaluating it formally, perhaps through an intergroup-based clinical trial. In the meanwhile, we believe that BSOR should be considered an investigational risk management option of unproven clinical usefulness, particularly because delay in bilateral oophorectomy theoretically could reduce the protective effect against breast cancer that has been documented in women who have undergone RRSO. C1 [Greene, Mark H.; Mai, Phuong L.] NCI, Div Canc Epidemiol & Genet, Clin Genet Branch, Rockville, MD USA. [Schwartz, Peter E.] Yale Univ, Sch Med, Div Gynecol Oncol, Dept Obstet Gynecol & Reprod Sci, New Haven, CT USA. RP Greene, MH (reprint author), NCI, Div Canc Epidemiol & Genet, Clin Genet Branch, Rockville, MD USA. FU Intramural NIH HHS [ZIA CP010145-11] NR 44 TC 4 Z9 5 U1 0 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2011 VL 204 IS 1 AR 19.e1 DI 10.1016/j.ajog.2010.05.038 PG 6 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 698VU UT WOS:000285622500008 PM 20619389 ER PT J AU Rodriguez, AC Schiffman, M Herrero, R Hildesheim, A Wacholder, S Burk, RD AF Cecilia Rodriguez, Ana Schiffman, Mark Herrero, Rolando Hildesheim, Allan Wacholder, Sholom Burk, Robert D. TI Re: Longitudinal Study of Human Papillomavirus Persistence and Cervical Intraepithelial Neoplasia Grade 2/3: Critical Role of Duration of Infection, Response SO JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE LA English DT Letter ID PARTICLE VACCINE; YOUNG-WOMEN; TRIAL C1 [Cecilia Rodriguez, Ana; Herrero, Rolando] Fdn INCIENSA, Proyecto Epidemiol Guanacaste, San Jose, Costa Rica. [Schiffman, Mark] NCI, Genet Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Rockville, MD USA. [Hildesheim, Allan] NCI, Infect & Immunoepidemiol Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Rockville, MD USA. [Wacholder, Sholom] NCI, Biostat Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Rockville, MD USA. [Burk, Robert D.] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10467 USA. RP Rodriguez, AC (reprint author), Fdn INCIENSA, Proyecto Epidemiol Guanacaste, 7mo Piso, San Jose, Costa Rica. EM acrodriguez@racsa.co.cr RI Hildesheim, Allan/B-9760-2015 OI Hildesheim, Allan/0000-0003-0257-2363 NR 7 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0027-8874 EI 1460-2105 J9 JNCI-J NATL CANCER I JI JNCI-J. Natl. Cancer Inst. PD JAN PY 2011 VL 103 IS 2 DI 10.1093/jnci/djq485 PG 2 WC Oncology SC Oncology GA 709WT UT WOS:000286472800013 ER PT J AU Wacholder, S Han, SS Weinberg, CR AF Wacholder, Sholom Han, Summer S. Weinberg, Clarice R. TI Inference From a Multiplicative Model of Joint Genetic Effects or Ovarian Cancer Risk SO JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE LA English DT Editorial Material ID ASHKENAZI JEWISH CARRIERS; GENOME-WIDE ASSOCIATION; MULTISTAGE CARCINOGENESIS; BRCA2 MUTATIONS; BLADDER-CANCER C1 [Wacholder, Sholom; Han, Summer S.] NCI, Div Canc Epidemiol & Genet, Biostat Branch, Bethesda, MD 20892 USA. [Weinberg, Clarice R.] NIEHS, Biostat Branch, Res Triangle Pk, NC 27709 USA. RP Wacholder, S (reprint author), NCI, Div Canc Epidemiol & Genet, NIH, 6120 Execut Blvd,EPS 5050,MSC-7244, Rockville, MD 20892 USA. EM Wacholds@mail.nih.gov NR 11 TC 1 Z9 1 U1 0 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0027-8874 EI 1460-2105 J9 JNCI-J NATL CANCER I JI JNCI-J. Natl. Cancer Inst. PD JAN PY 2011 VL 103 IS 2 DI 10.1093/jnci/djq510 PG 2 WC Oncology SC Oncology GA 709WT UT WOS:000286472800002 ER PT J AU Kriegel, C Koehne, J Tinkle, S Maynard, AD Hill, RA AF Kriegel, Christina Koehne, Jessica Tinkle, Sally Maynard, Andrew D. Hill, Rodney A. TI Challenges of Trainees in a Multidisciplinary Research Program: Nano-Biotechnology SO JOURNAL OF CHEMICAL EDUCATION LA English DT Article C1 [Koehne, Jessica] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA. [Koehne, Jessica] NASA, Ames Res Ctr, Moffett Field, CA 94035 USA. [Tinkle, Sally] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC 27709 USA. [Maynard, Andrew D.] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA. [Maynard, Andrew D.] Univ Michigan, Sch Publ Hlth, Risk Sci Ctr, Ann Arbor, MI 48109 USA. [Hill, Rodney A.] Univ Idaho, Dept Anim & Vet Sci, Moscow, ID 83844 USA. [Kriegel, Christina] Univ Massachusetts, Dept Food Sci, Amherst, MA 01003 USA. RP Kriegel, C (reprint author), Northeastern Univ, Dept Pharmaceut Sci, Boston, MA 02115 USA. EM rodhill@uidaho.edu OI Maynard, Andrew/0000-0003-2117-5128 NR 12 TC 1 Z9 1 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0021-9584 J9 J CHEM EDUC JI J. Chem. Educ. PD JAN PY 2011 VL 88 IS 1 BP 53 EP 55 DI 10.1021/ed1001174 PG 3 WC Chemistry, Multidisciplinary; Education, Scientific Disciplines SC Chemistry; Education & Educational Research GA 694WE UT WOS:000285328900014 ER PT J AU Sztein, JM AF Sztein, Jorge M. TI Ovarian transplant for transgenic rescue SO LAB ANIMAL LA English DT Letter ID MOUSE OVARIES; MICE; LINE C1 NIAID, Cryopreservat Unit, NIH, Rockville, MD USA. RP Sztein, JM (reprint author), NIAID, Cryopreservat Unit, NIH, Rockville, MD USA. EM szteinj@niaid.nih.gov OI Sztein, Jorge Mario/0000-0001-7047-2634 NR 10 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0093-7355 J9 LAB ANIMAL JI Lab Anim. PD JAN PY 2011 VL 40 IS 1 BP 9 EP 9 DI 10.1038/laban0111-9a PG 1 WC Veterinary Sciences SC Veterinary Sciences GA 700KM UT WOS:000285737700012 PM 21173762 ER PT J AU McMahon, FJ Akula, N Cichon, S Detera-Wadleigh, SD Edenberg, H Holsboer, F Nothen, MM Nurnberger, JI Potash, J Preisig, M Rietschel, M Schulze, TG AF McMahon, Francis J. Akula, Nirmala Cichon, Sven Detera-Wadleigh, Sevilla D. Edenberg, Howard Holsboer, Florian Noethen, Markus M. Nurnberger, John I. Potash, James Preisig, Martin Rietschel, Marcella Schulze, Thomas G. TI Replication of association of 3p21.1 with susceptibility to bipolar disorder but not major depression Reply SO NATURE GENETICS LA English DT Letter ID GENOME-WIDE ASSOCIATION C1 [McMahon, Francis J.; Akula, Nirmala; Detera-Wadleigh, Sevilla D.; Schulze, Thomas G.] NIMH, Genet Basis Mood & Anxiety Disorders Sect, NIH, US Dept HHS, Bethesda, MD 20892 USA. [Cichon, Sven; Noethen, Markus M.] Univ Bonn, Life & Brain Ctr, Dept Genom, D-5300 Bonn, Germany. [Cichon, Sven; Noethen, Markus M.] Univ Bonn, Inst Human Genet, D-5300 Bonn, Germany. [Edenberg, Howard; Nurnberger, John I.] Indiana Univ Purdue Univ, Indianapolis, IN 46202 USA. [Holsboer, Florian] Max Planck Inst Psychiat, D-80804 Munich, Germany. [Potash, James] Johns Hopkins Univ, Sch Med, Dept Psychiat, Baltimore, MD 21205 USA. [Preisig, Martin] Univ Hosp Ctr, Lausanne, Switzerland. [Preisig, Martin] Univ Lausanne, Dept Psychiat, Lausanne, Switzerland. [Rietschel, Marcella; Schulze, Thomas G.] Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, D-6800 Mannheim, Germany. [Schulze, Thomas G.] Univ Goettingen, Dept Psychiat & Psychotherapy, Gottingen, Germany. RP McMahon, FJ (reprint author), NIMH, Genet Basis Mood & Anxiety Disorders Sect, NIH, US Dept HHS, Bethesda, MD 20892 USA. EM mcmahonf@mail.nih.gov RI Schulze, Thomas/H-2157-2013; Cichon, Sven/H-8803-2013; Cichon, Sven/B-9618-2014; OI Cichon, Sven/0000-0002-9475-086X; Cichon, Sven/0000-0002-9475-086X; McMahon, Francis/0000-0002-9469-305X NR 6 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1061-4036 J9 NAT GENET JI Nature Genet. PD JAN PY 2011 VL 43 IS 1 BP 5 EP 5 DI 10.1038/ng0111-5 PG 1 WC Genetics & Heredity SC Genetics & Heredity GA 699SQ UT WOS:000285683500003 ER PT J AU Patrick, H Canevello, A AF Patrick, Heather Canevello, Amy TI Methodological overview of a self-determination theory-based computerized intervention to promote leisure-time physical activity SO PSYCHOLOGY OF SPORT AND EXERCISE LA English DT Article DE Computerized intervention; Self-determination theory; Autonomy support; Personal trainers; Physical activity ID AUTONOMY SUPPORT; INTRINSIC MOTIVATION; EHEALTH INTERVENTIONS; SMOKING CESSATION; EXERCISE; SPORT; STYLE; BEHAVIORS; MODEL; RISK AB Objectives: To provide a methodological overview of a computerized intervention to promote leisure-time physical activity (PA) and to apply self-determination theory (SDT) to PA initiation to better understand the psychological mechanisms underlying PA frequency, intensity, and duration in previously-sedentary individuals. Design: Based on SDT, two computerized personal trainers were developed for use with sedentary young adults. One personal trainer was designed to be need-supportive, empathic, and structured while the other was designed to be more controlling, evaluative, and judgmental. Method: Participants are randomly assigned to work with either the need-supportive or controlling computerized personal trainer. They complete a series of 7 weekly training sessions. In between training sessions, participants complete daily records of PA behaviors and experiences including autonomous self-regulation and perceived competence for PA and PA frequency, intensity, and duration. Potential contributions: The design of this intervention and its theoretical basis have important implications for advancing the field of exercise science specifically and health behavior change more broadly. Computerized interventions have the benefit of standardizing intervention content as well as reducing clinical contact burden for practitioners. Daily recording procedures reduce the likelihood of retrospection bias and allow for the modeling of (1) daily fluctuations in PA behavior and (2) the psychological mechanisms believed to be involved in PA behavior (e.g., autonomous self-regulation). Finally, as a broad theory of human motivation, SOT is uniquely positioned to offer explanations for the conditions that are likely to promote both the initiation and maintenance of health behavior change. Published by Elsevier Ltd. C1 [Patrick, Heather] Univ Rochester, Dept Med, Rochester, NY USA. [Patrick, Heather] Univ Rochester, Dept Clin & Social Psychol, Rochester, NY USA. [Canevello, Amy] Univ Michigan, Inst Social Res, Ann Arbor, MI USA. RP Patrick, H (reprint author), NCI, DCCPS BRP HPRB, 6130 Execut Blvd,EPN Room 4076,MSC 7335, Rockville, MD 20852 USA. EM patrickha@gmail.nih.gov FU National Cancer Institute [R21 CA 109961] FX This research was supported by R21 CA 109961 from the National Cancer Institute to the first author while she was at Baylor College of Medicine and, subsequently the University of Rochester. NR 75 TC 12 Z9 12 U1 8 U2 37 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1469-0292 J9 PSYCHOL SPORT EXERC JI Psychol. Sport Exerc. PD JAN PY 2011 VL 12 IS 1 BP 13 EP 19 DI 10.1016/j.psychsport.2010.04.011 PG 7 WC Hospitality, Leisure, Sport & Tourism; Psychology, Applied; Psychology; Sport Sciences SC Social Sciences - Other Topics; Psychology; Sport Sciences GA 693OE UT WOS:000285232600003 PM 21103069 ER PT J AU Le, K Coelho, C Mozeiko, J Krueger, F Grafman, J AF Le, Karen Coelho, Carl Mozeiko, Jennifer Krueger, Frank Grafman, Jordan TI Measuring goodness of story narratives: Implications for traumatic brain injury SO APHASIOLOGY LA English DT Article; Proceedings Paper CT 40th Clinical Aphasiology Conference (CAC) CY MAY 23-27, 2010 CL Isle of Palms, SC DE Discourse production; Narrative discourse; Traumatic brain injury; Discourse analysis; Penetrating head injury; Story narratives ID CLOSED-HEAD-INJURY; PRAGMATIC LANGUAGE-SKILLS; DISCOURSE PRODUCTION; WORKING-MEMORY; CHILDREN; ADULTS; COMPREHENSION; ABILITY; NEEDS AB Background: This study examined the utility of story ogoodnesso, a measure of organisation and completeness, in quantifying narrative discourse deficits following traumatic brain injury (TBI). In an initial study, the story goodness measure demonstrated sensitivity and reliability in distinguishing individuals who had TBI from those who were non-brain-injured. Aims: The purpose of the current study was to validate previous findings of the story goodness index, specifically in discriminating performance between groups and identifying performance subgroups, in a larger sample of participants with TBI. Methods Procedures: A total of 46 non-brain-injured adults and 171 adults with TBI participated. Story retellings were analysed for story grammar and story completeness. The two discourse scores were then plotted as coordinates, which allowed for quantification of story goodness. Statistical analyses included a multivariate analysis of variance and calculation of Pearson correlation coefficients for the discourse measures. Outcomes Results: Results indicated that participants' scores clustered differentially across quadrants between groups and discriminated groups into four distinct categories of story ogoodnesso. Conclusions: Findings paralleled those found in the initial study, suggesting that story goodness is a sensitive measure for examining the discourse of individuals with TBI. The story goodness has potential clinical utility and may have implications for investigation of discourse impairments in other clinical populations and treatment of discourse deficits. C1 [Grafman, Jordan] NINDS, Cognit Neurosci Sect, Magnuson Clin Ctr, Bethesda, MD 20892 USA. [Le, Karen; Coelho, Carl; Mozeiko, Jennifer] Univ Connecticut, Dept Commun Sci, Storrs, CT 06268 USA. RP Grafman, J (reprint author), NINDS, Cognit Neurosci Sect, Magnuson Clin Ctr, Bldg 10,7D43,MSC 1440,10 Ctr Dr, Bethesda, MD 20892 USA. EM GrafmanJ@ninds.nih.gov OI Grafman, Jordan H./0000-0001-8645-4457 NR 30 TC 7 Z9 7 U1 4 U2 9 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0268-7038 EI 1464-5041 J9 APHASIOLOGY JI Aphasiology PY 2011 VL 25 IS 6-7 BP 748 EP 760 AR PII 938548156 DI 10.1080/02687038.2010.539696 PG 13 WC Clinical Neurology SC Neurosciences & Neurology GA 775XO UT WOS:000291497000008 ER PT J AU Mozeiko, J Le, K Coelho, C Krueger, F Grafman, J AF Mozeiko, Jennifer Le, Karen Coelho, Carl Krueger, Frank Grafman, Jordan TI The relationship of story grammar and executive function following TBI SO APHASIOLOGY LA English DT Article; Proceedings Paper CT 40th Clinical Aphasiology Conference (CAC) CY MAY 23-27, 2010 CL Isle of Palms, SC DE Traumatic brain injury; penetrating head injury; Discourse analysis; narrative discourse; Story grammar; Executive function ID TRAUMATIC BRAIN-INJURY; DEFICITS; ADULTS AB Background: Story grammar is a super-structural measure of discourse performance that has shown to be sensitive to the deficits seen following traumatic brain injury (TBI). Narrative organisation and identification of logical relationships between events and characters are key components of story grammar. Reports of significant correlations for measures of story grammar and scores from various tests of executive functioning for individuals with TBI are thought to reflect executive control of cognitive and linguistic organisational processes. Aims: The purpose of the present study was to re-examine the relationship between story grammar and executive functions (EF) in a large group of participants with severe TBI secondary to diverse penetrating head wounds. It was hypothesised that participants with TBI would have significantly lower story grammar scores than a comparison group without TBI, and that story grammar performance of the group with TBI would be significantly correlated with their EF scores. Methods Procedures: A total of 167 participants with TBI and a comparison group of 46 adults without TBI were asked to retell a 16-frame story. Transcripts of each story retelling were broken into T-units and were analysed for story grammar. Outcomes Results: Results of MANOVA showed significant effect of group on the discourse measures. Univariate tests showed significant differences between the group with TBI and the comparison group for each of the story grammar measures. Story grammar measures were significantly correlated with executive function (EF) scores. Conclusions: Results indicated that the participants with TBI demonstrated significantly poorer performance on measures of story grammar abilities, lending support to earlier reports of story grammar impairments resulting from closed head injury (CHI). The present study also found significant correlations for measures of story grammar and the Sorting Test. Cognitive skills such as mental flexibility, required for successful performance on this card sorting task are likely the same as those required for episode generation. These findings have clinical implications for the management of cognitive-communication disorders in individuals with TBI. First, story grammar warrants inclusion in analyses of discourse. Second, discourse deficits following brain injury do not resolve spontaneously and persist as social barriers. C1 [Mozeiko, Jennifer; Le, Karen; Coelho, Carl] Univ Connecticut, Dept Commun Disorders, Storrs, CT USA. [Krueger, Frank; Grafman, Jordan] NINDS, Cognit Neurosci Sect, Bethesda, MD 20892 USA. RP Grafman, J (reprint author), Kessler Fdn Res Ctr, Traumat Brain Injury Res Lab, 1199 Pleasant Valley Way, W Orange, NJ 07052 USA. EM jgrafman@kesslerfoundation.org OI Grafman, Jordan H./0000-0001-8645-4457 NR 28 TC 14 Z9 14 U1 0 U2 4 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0268-7038 EI 1464-5041 J9 APHASIOLOGY JI Aphasiology PY 2011 VL 25 IS 6-7 BP 826 EP 835 AR PII 934165989 DI 10.1080/02687038.2010.543983 PG 10 WC Clinical Neurology SC Neurosciences & Neurology GA 775XO UT WOS:000291497000014 ER PT J AU Lee, K Kang, SG Liu, XF Seo, D AF Lee, Keunbaik Kang, Sanggil Liu, Xuefeng Seo, Daekwan TI Likelihood-based approach for analysis of longitudinal nominal data using marginalized random effects models SO JOURNAL OF APPLIED STATISTICS LA English DT Article DE likelihood-based model; random effects; marginal model; Quasi-Newton; Kronecker product ID LOGISTIC-NORMAL MODELS; BINARY DATA; REGRESSION-MODEL; CATEGORICAL-DATA; ORDINAL DATA; INFERENCE AB Likelihood-based marginalized models using random effects have become popular for analyzing longitudinal categorical data. These models permit direct interpretation of marginal mean parameters and characterize the serial dependence of longitudinal outcomes using random effects [12,22]. In this paper, we propose model that expands the use of previous models to accommodate longitudinal nominal data. Random effects using a new covariance matrix with a Kronecker product composition are used to explain serial and categorical dependence. The Quasi-Newton algorithm is developed for estimation. These proposed methods are illustrated with a real data set and compared with other standard methods. C1 [Lee, Keunbaik] Louisiana State Univ, Hlth Sci Ctr, New Orleans, LA 70122 USA. [Kang, Sanggil] Sangji Univ, Dept Data Informat, Wonju, South Korea. [Liu, Xuefeng] E Tennessee State Univ, Coll Publ Hlth, Dept Biostat & Epidemiol, Johnson City, TN 37614 USA. [Seo, Daekwan] NCI, Expt Carcinogenesis Lab, NIH, Bethesda, MD 20892 USA. RP Lee, K (reprint author), Louisiana State Univ, Hlth Sci Ctr, New Orleans, LA 70122 USA. EM klee4@lsuhsc.edu NR 34 TC 4 Z9 4 U1 0 U2 1 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 0266-4763 EI 1360-0532 J9 J APPL STAT JI J. Appl. Stat. PY 2011 VL 38 IS 8 BP 1577 EP 1590 DI 10.1080/02664763.2010.515675 PG 14 WC Statistics & Probability SC Mathematics GA 775MU UT WOS:000291464400003 ER PT S AU Bi, M Summers, RM Yao, JH AF Bi, Mark Summers, Ronald M. Yao, Jianhua BE Weaver, JB Molthen, RC TI 3-Dimensional Automatic Computer-Aided Evaluation of Pleural Effusions on Chest CT Images SO MEDICAL IMAGING 2011: BIOMEDICAL APPLICATIONS IN MOLECULAR, STRUCTURAL, AND FUNCTIONAL IMAGING SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Medical Imaging 2011 - Biomedical Applications in Molecular, Structural, and Functional Imaging CY FEB 13-16, 2011 CL Lake Buena Vista, FL SP SPIE, Dynasil Corp/RMD Res, Amer Assoc Physicists Med (AAPM), DQE Instruments, Inc, Ocean Thin Films Inc, Coll Opt & Photon (CREOL), Univ Cent Florida, VIDA Diagnost, Inc DE pleural effusion; chest CT AB The ability to estimate the volume of pleural effusions is desirable as it can provide information about the severity of the condition and the need for thoracentesis. We present here an improved version of an automated program to measure the volume of pleural effusions using regular chest CT images. First, the lungs are segmented using region growing, mathematical morphology, and anatomical knowledge. The visceral and parietal layers of the pleura are then extracted based on anatomical landmarks, curve fitting and active contour models. The liver and compressed tissues are segmented out using thresholding. The pleural space is then fitted to a Bezier surface which is subsequently projected onto the individual two-dimensional slices. Finally, the volume of the pleural effusion is quantified. Our method was tested on 15 chest CT studies and validated against three separate manual tracings. The Dice coefficients were 0.74+/-0.07, 0.74+/-0.08, and 0.75+/-0.07 respectively, comparable to the variation between two different manual tracings. C1 [Bi, Mark; Summers, Ronald M.; Yao, Jianhua] NIH, Radiol & Imaging Sci Dept, Ctr Clin, Bethesda, MD 20892 USA. RP Bi, M (reprint author), NIH, Radiol & Imaging Sci Dept, Ctr Clin, Bethesda, MD 20892 USA. EM jyao@cc.nih.gov NR 5 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-507-6 J9 PROC SPIE PY 2011 VL 7965 AR 79651W DI 10.1117/12.878047 PG 7 WC Engineering, Electrical & Electronic; Optics; Imaging Science & Photographic Technology; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Optics; Imaging Science & Photographic Technology; Radiology, Nuclear Medicine & Medical Imaging GA BVF69 UT WOS:000291388700064 ER PT S AU Pura, JA Hamilton, AM Vargish, GA Butman, JA Linguraru, MG AF Pura, John A. Hamilton, Allison M. Vargish, Geoffrey A. Butman, John A. Linguraru, Marius George BE Weaver, JB Molthen, RC TI Automated Segmentation of Ventricles from Serial Brain MRI for the Quantification of Volumetric Changes Associated with Communicating Hydrocephalus in Patients with Brain Tumor SO MEDICAL IMAGING 2011: BIOMEDICAL APPLICATIONS IN MOLECULAR, STRUCTURAL, AND FUNCTIONAL IMAGING SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Medical Imaging 2011 - Biomedical Applications in Molecular, Structural, and Functional Imaging CY FEB 13-16, 2011 CL Lake Buena Vista, FL SP SPIE, Dynasil Corp/RMD Res, Amer Assoc Physicists Med (AAPM), DQE Instruments, Inc, Ocean Thin Films Inc, Coll Opt & Photon (CREOL), Univ Cent Florida, VIDA Diagnost, Inc DE Brain imaging; MRI; brain tumor; communicating hydrocephalus; segmentation; monitoring ID NONRIGID REGISTRATION; IMAGES; EXTRACTION; ROBUST AB Accurate ventricle volume estimates could improve the understanding and diagnosis of postoperative communicating hydrocephalus. For this category of patients, associated changes in ventricle volume can be difficult to identify, particularly over short time intervals. We present an automated segmentation algorithm that evaluates ventricle size from serial brain MRI examination. The technique combines serial T1-weighted images to increase SNR and segments the means image to generate a ventricle template. After pre-processing, the segmentation is initiated by a fuzzy c-means clustering algorithm to find the seeds used in a combination of fast marching methods and geodesic active contours. Finally, the ventricle template is propagated onto the serial data via non-linear registration. Serial volume estimates were obtained in an automated robust and accurate manner from difficult data. C1 [Pura, John A.; Hamilton, Allison M.; Vargish, Geoffrey A.; Butman, John A.; Linguraru, Marius George] NIH, Ctr Clin, Bethesda, MD 20892 USA. RP Pura, JA (reprint author), NIH, Ctr Clin, Bethesda, MD 20892 USA. EM lingurarum@mail.nih.gov RI Butman, John/J-2780-2013 OI Butman, John/0000-0002-1547-9195 NR 17 TC 0 Z9 0 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-507-6 J9 PROC SPIE PY 2011 VL 7965 AR 79650P DI 10.1117/12.877679 PG 8 WC Engineering, Electrical & Electronic; Optics; Imaging Science & Photographic Technology; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Optics; Imaging Science & Photographic Technology; Radiology, Nuclear Medicine & Medical Imaging GA BVF69 UT WOS:000291388700023 ER PT S AU Yao, JH Sussman, DL Summers, RM AF Yao, Jianhua Sussman, Daniel L. Summers, Ronald M. BE Weaver, JB Molthen, RC TI Fully Automated Adipose Tissue Measurement on Abdominal CT SO MEDICAL IMAGING 2011: BIOMEDICAL APPLICATIONS IN MOLECULAR, STRUCTURAL, AND FUNCTIONAL IMAGING SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Medical Imaging 2011 - Biomedical Applications in Molecular, Structural, and Functional Imaging CY FEB 13-16, 2011 CL Lake Buena Vista, FL SP SPIE, Dynasil Corp/RMD Res, Amer Assoc Physicists Med (AAPM), DQE Instruments, Inc, Ocean Thin Films Inc, Coll Opt & Photon (CREOL), Univ Cent Florida, VIDA Diagnost, Inc DE subcutaneous adipose tissue; visceral adipose tissue; abdominal CT ID BODY-COMPOSITION AB Obesity has become widespread in America and has been associated as a risk factor for many illnesses. Adipose tissue (AT) content, especially visceral AT (VAT), is an important indicator for risks of many disorders, including heart disease and diabetes. Measuring adipose tissue (AT) with traditional means is often unreliable and inaccurate. CT provides a means to measure AT accurately and consistently. We present a fully automated method to segment and measure abdominal AT in CT. Our method integrates image preprocessing which attempts to correct for image artifacts and inhomogeneities. We use fuzzy c-means to cluster AT regions and active contour models to separate subcutaneous and visceral AT. We tested our method on 50 abdominal CT scans and evaluated the correlations between several measurements. C1 [Yao, Jianhua; Sussman, Daniel L.; Summers, Ronald M.] NIH, Ctr Clin, Radiol & Imaging Sci Dept, Bethesda, MD 20892 USA. RP Yao, JH (reprint author), NIH, Ctr Clin, Radiol & Imaging Sci Dept, Bethesda, MD 20892 USA. EM jyao@cc.nih.gov NR 13 TC 4 Z9 4 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-507-6 J9 PROC SPIE PY 2011 VL 7965 AR 79651Z DI 10.1117/12.878063 PG 6 WC Engineering, Electrical & Electronic; Optics; Imaging Science & Photographic Technology; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Optics; Imaging Science & Photographic Technology; Radiology, Nuclear Medicine & Medical Imaging GA BVF69 UT WOS:000291388700067 ER PT S AU Ptak, K Farrell, D Hinkal, G Panaro, NJ Hook, S Grodzinski, P AF Ptak, Krzysztof Farrell, Dorothy Hinkal, George Panaro, Nicholas J. Hook, Sara Grodzinski, Piotr BE George, T Islam, MS Dutta, AK TI Cancer Nanotechnology: a new commercialization pipeline for diagnostics, imaging agents and therapies SO MICRO- AND NANOTECHNOLOGY SENSORS, SYSTEMS, AND APPLICATIONS III SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Micro- and Nanotechnology Sensors, Systems, and Applications III CY APR 25-29, 2011 CL Orlando, FL SP SPIE DE nanotechnology; oncology; imaging; diagnostic; treatment; multidisciplinary research team ID TARGETED NANOPARTICLES; TOMOSYNTHESIS; DESIGN; FIELD AB Nanotechnology - the science and engineering of manipulating matter at the molecular scale to create devices with novel chemical, physical and biological properties - has the potential to radically change oncology. Research sponsored by the NCI Alliance for Nanotechnology in Cancer has led to the development of nanomaterials as platforms of increasing complexity and devices of superior sensitivity, speed and multiplexing capability. Input from clinicians has guided researchers in the design of technologies to address specific needs in the areas of cancer therapy and therapeutic monitoring, in vivo imaging, and in vitro diagnostics. The promising output from the Alliance has led to many new companies being founded to commercialize their nanomedical product line. Furthermore, several of these technologies, which are discussed in this paper, have advanced to clinically testing. C1 [Ptak, Krzysztof; Farrell, Dorothy; Hinkal, George; Hook, Sara; Grodzinski, Piotr] NCI, Off Canc Nanotechnol Res, Ctr Strateg Sci Initiat, Off Director,NIH, Bethesda, MD 20892 USA. RP Ptak, K (reprint author), NCI, Off Canc Nanotechnol Res, Ctr Strateg Sci Initiat, Off Director,NIH, 31 Ctr Dr, Bethesda, MD 20892 USA. NR 14 TC 0 Z9 0 U1 1 U2 3 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-605-9 J9 PROC SPIE PY 2011 VL 8031 AR 80311S DI 10.1117/12.884607 PG 11 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Optics SC Engineering; Science & Technology - Other Topics; Optics GA BVG10 UT WOS:000291441400056 ER PT J AU Niu, SQ Ichiye, T AF Niu, Shuqiang Ichiye, Toshiko TI Density functional theory calculations of redox properties of iron-sulphur protein analogues SO MOLECULAR SIMULATION LA English DT Article DE density functional theory; iron-sulphur protein; reduction potential; inner-sphere free energy; reorganisation energy ID EXCHANGE-CORRELATION FUNCTIONALS; ELECTRON-TRANSFER REACTIONS; TRANSITION-METAL-COMPLEXES; EFFECTIVE CORE POTENTIALS; CUBANE 4FE-4S CLUSTER; PHOTOELECTRON-SPECTROSCOPY; ACTIVE-SITES; BASIS-SETS; MOLECULAR-DYNAMICS; CLOSTRIDIUM-PASTEURIANUM AB Acentral issue in understanding redox properties of iron-sulphur (Fe-S) proteins is determining the factors that tune the reduction potentials of the Fe-S clusters. Studies of redox site analogues play an important role, particularly because individual factors can be examined independently of the environment by combining calculations and experiments of carefully designed ligands for the analogues. For iron-sulphur analogues, our study has shown that broken-symmetry density functional theory gives good energetics when the geometry is optimised using B3LYP with a double-zeta basis set with polarisation functions, and the energies of these geometries are calculated using B3LYP with additional diffuse functions added to the sulphurs. A comparison of our calculated energies for redox site analogues in the gas phase against electron detachment energies measured by a combination of electrospray ionisation and photoelectron spectroscopy (EI-PES) by Wang and co-workers has been essential because the comparison is for exactly the same molecule with no approximation for the environment. Overall, the correlation of our B3LYP/6-31(++)(S)G**//B3LYP/6-31G** detachment energies with EI-PES experiments is excellent for a wide variety of analogues. Moreover, our calculations at this level have provided insight into a wide variety of properties of iron-sulphur proteins. C1 [Niu, Shuqiang; Ichiye, Toshiko] Georgetown Univ, Dept Chem, Washington, DC 20057 USA. [Ichiye, Toshiko] NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA. RP Ichiye, T (reprint author), Georgetown Univ, Dept Chem, Washington, DC 20057 USA. EM ti9@georgetown.edu FU National Institutes of Health [GM-45303]; US DOE Office of Biological and Environmental Research and located at Pacific Northwest National Laboratory [GC3565, GC20901, EMSL38793] FX This study was supported by a grant from the National Institutes of Health (GM-45303). The calculations were performed at the EMSL, a national user facility sponsored by the US DOE's Office of Biological and Environmental Research and located at Pacific Northwest National Laboratory, operated for DOE by Battelle, under the grant GC3565, GC20901 and EMSL38793. Additional computational resources were provided by the William G. McGowan Foundation. NR 116 TC 8 Z9 8 U1 1 U2 16 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0892-7022 J9 MOL SIMULAT JI Mol. Simul. PY 2011 VL 37 IS 7 BP 572 EP 590 DI 10.1080/08927022.2011.582111 PG 19 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 774YU UT WOS:000291423500006 ER PT J AU Morris, BA Shakespeare-Finch, J AF Morris, Bronwyn A. Shakespeare-Finch, Jane TI Cancer Diagnostic Group Differences in Posttraumatic Growth: Accounting for Age, Gender, Trauma Severity, and Distress SO JOURNAL OF LOSS & TRAUMA LA English DT Article ID BREAST-CANCER; SURVIVORS; STRESS; PREVALENCE; INVENTORY AB The type of cancer diagnosed can have a differential impact on postdiagnosis adjustment (e. g., coping strategies, likelihood to complete treatment). Investigations examining cancer diagnostic differences in posttraumatic growth (PTG) are yet to be published. The current study examined 235 participants who had been treated at a regional hospital for all forms of cancer. Group differences in PTG were assessed through a cross-sectional design between breast, prostate, hematological, and colorectal cancer survivors. Results demonstrated that breast cancer survivors reported significantly higher levels of PTG than those diagnosed with colorectal and hematological malignancies, but not significantly different from prostate cancer survivors. While cancer diagnostic group differences in PTG were evident, PTG levels were also positively associated with trauma severity and distress. These results are discussed in terms of developing a postdiagnosis care model that can be utilized across all cancer type diagnoses in order to assist adaptation during this challenging time. C1 [Shakespeare-Finch, Jane] Queensland Univ Technol, Sch Psychol & Counselling, Kelvin Grove, Qld 4059, Australia. [Morris, Bronwyn A.] NHGRI, NIH, Bethesda, MD 20892 USA. RP Shakespeare-Finch, J (reprint author), Queensland Univ Technol, Sch Psychol & Counselling, Victoria Pk Rd, Kelvin Grove, Qld 4059, Australia. EM j.shakespeare-finch@qut.edu.au OI Shakespeare-Finch, Jane/0000-0003-4237-1320 NR 26 TC 8 Z9 8 U1 2 U2 8 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1532-5024 J9 J LOSS TRAUMA JI J. Loss Trauma PY 2011 VL 16 IS 3 BP 229 EP 242 DI 10.1080/15325024.2010.519292 PG 14 WC Psychology, Social SC Psychology GA 766LQ UT WOS:000290784200003 ER PT J AU Airavaara, M Harvey, BK Voutilainen, MH Chou, J Lindholm, P Lindahl, M Tuominen, RK Saarma, M Wang, Y Hoffer, B AF Airavaara, M. Harvey, B. K. Voutilainen, M. H. Chou, J. Lindholm, P. Lindahl, M. Tuominen, R. K. Saarma, M. Wang, Y. Hoffer, B. TI CDNF Protects the Nigrostriatal Dopamine System and Promotes Recovery After MPTP Treatment n Mice SO CELL TRANSPLANTATION LA English DT Meeting Abstract CT 11th International Neural Transplantation and Repair Meeting/18th Annual Meeting of the American-Society-for-Neural-Therapy-and-Repair CY MAY 04-08, 2011 CL Clearwater, FL SP Amer Soc Neural Therapy & Repair C1 [Airavaara, M.; Harvey, B. K.; Chou, J.; Wang, Y.; Hoffer, B.] Natl Inst Drug Abuse, Intramural Res Program, NIH, Baltimore, MD USA. [Voutilainen, M. H.; Tuominen, R. K.] Univ Helsinki, Dept Pharmacol & Toxicol, Fac Pharm, FIN-00170 Helsinki, Finland. [Lindholm, P.; Lindahl, M.; Saarma, M.] Univ Helsinki, Inst Biotechnol, Helsinki, Finland. OI Airavaara, Mikko/0000-0002-2026-1609 NR 0 TC 0 Z9 0 U1 0 U2 2 PU COGNIZANT COMMUNICATION CORP PI ELMSFORD PA 3 HARTSDALE ROAD, ELMSFORD, NY 10523-3701 USA SN 0963-6897 J9 CELL TRANSPLANT JI Cell Transplant. PY 2011 VL 20 IS 4 BP 544 EP 545 PG 2 WC Cell & Tissue Engineering; Medicine, Research & Experimental; Transplantation SC Cell Biology; Research & Experimental Medicine; Transplantation GA 758VZ UT WOS:000290196600012 ER PT J AU Airavaara, M Harvey, BK Hinzman, J Simons, EM Chiocco, MJ Howard, DB Shen, H Gerhardt, G Hoffer, BJ Wang, Y AF Airavaara, M. Harvey, B. K. Hinzman, J. Simons, E. M. Chiocco, M. J. Howard, D. B. Shen, H. Gerhardt, G. Hoffer, B. J. Wang, Y. TI Intracortical Delivery of an Adeno-Associated Viral Vector Expressing the Glutamate Transporter (GLT-1) Decreases Stroke-Induced Extracellular Glutamate Overflow and Cerebral Infarction After Transient Middle Cerebral Artery Occlusion in Rats SO CELL TRANSPLANTATION LA English DT Meeting Abstract CT 11th International Neural Transplantation and Repair Meeting/18th Annual Meeting of the American-Society-for-Neural-Therapy-and-Repair CY MAY 04-08, 2011 CL Clearwater, FL SP Amer Soc Neural Therapy & Repair C1 [Airavaara, M.; Harvey, B. K.; Simons, E. M.; Chiocco, M. J.; Howard, D. B.; Shen, H.; Hoffer, B. J.; Wang, Y.] Natl Inst Drug Abuse, Intramural Res Program, NIH, Baltimore, MD USA. [Hinzman, J.; Gerhardt, G.] Univ Kentucky, Dept Anat & Neurobiol, Coll Med, Ctr Microelectrode Technol, Lexington, KY 40536 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU COGNIZANT COMMUNICATION CORP PI ELMSFORD PA 3 HARTSDALE ROAD, ELMSFORD, NY 10523-3701 USA SN 0963-6897 J9 CELL TRANSPLANT JI Cell Transplant. PY 2011 VL 20 IS 4 BP 544 EP 544 PG 1 WC Cell & Tissue Engineering; Medicine, Research & Experimental; Transplantation SC Cell Biology; Research & Experimental Medicine; Transplantation GA 758VZ UT WOS:000290196600011 ER PT J AU Subramanian, T Venkiteswaran, K Rowlands, A Ramachandra, R Lieu, C Rao, A Chen, J Freed, W AF Subramanian, T. Venkiteswaran, K. Rowlands, A. Ramachandra, R. Lieu, C. Rao, A. Chen, J. Freed, W. TI Human Retinal Pigment Epithelial Cell (HRPEC) Cografts Improve Survival of Xenografted Dopaminergic Human Embryonic Stem Cells (hES), Diminish Host Inflammation, and Immune Response SO CELL TRANSPLANTATION LA English DT Meeting Abstract CT 11th International Neural Transplantation and Repair Meeting/18th Annual Meeting of the American-Society-for-Neural-Therapy-and-Repair CY MAY 04-08, 2011 CL Clearwater, FL SP Amer Soc Neural Therapy & Repair C1 [Subramanian, T.; Venkiteswaran, K.; Rowlands, A.; Ramachandra, R.; Lieu, C.; Rao, A.] Penn State Coll Med, Hershey, PA USA. [Chen, J.; Freed, W.] NIDA, Baltimore, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU COGNIZANT COMMUNICATION CORP PI ELMSFORD PA 3 HARTSDALE ROAD, ELMSFORD, NY 10523-3701 USA SN 0963-6897 J9 CELL TRANSPLANT JI Cell Transplant. PY 2011 VL 20 IS 4 BP 587 EP 588 PG 2 WC Cell & Tissue Engineering; Medicine, Research & Experimental; Transplantation SC Cell Biology; Research & Experimental Medicine; Transplantation GA 758VZ UT WOS:000290196600132 ER PT J AU Zhang, Y Huh, HKH Shan, L Malik, N Diaz-Ruiz, O Hoffer, BJ Granholm, AC Backman, CM AF Zhang, Y. Huh, H. K-H Shan, L. Malik, N. Diaz-Ruiz, O. Hoffer, B. J. Granholm, A-C Baeckman, C. M. TI Embryonic Dopamine Neurons Genetically Modified to Enhance Akt/PKB Activation Provide Functional Improvements When Transplanted Into the Striata of the MitoPark Mouse Model SO CELL TRANSPLANTATION LA English DT Meeting Abstract CT 11th International Neural Transplantation and Repair Meeting/18th Annual Meeting of the American-Society-for-Neural-Therapy-and-Repair CY MAY 04-08, 2011 CL Clearwater, FL SP Amer Soc Neural Therapy & Repair C1 [Zhang, Y.; Huh, H. K-H; Shan, L.; Malik, N.; Diaz-Ruiz, O.; Hoffer, B. J.; Baeckman, C. M.] NIDA, NIH, Cellular Neurobiol Branch, Baltimore, MD USA. [Granholm, A-C] Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU COGNIZANT COMMUNICATION CORP PI ELMSFORD PA 3 HARTSDALE ROAD, ELMSFORD, NY 10523-3701 USA SN 0963-6897 J9 CELL TRANSPLANT JI Cell Transplant. PY 2011 VL 20 IS 4 BP 591 EP 591 PG 1 WC Cell & Tissue Engineering; Medicine, Research & Experimental; Transplantation SC Cell Biology; Research & Experimental Medicine; Transplantation GA 758VZ UT WOS:000290196600143 ER PT S AU Chow, CC Ong, KM Dougherty, EJ Simons, SS AF Chow, Carson C. Ong, Karen M. Dougherty, Edward J. Simons, S. Stoney, Jr. BE Johnson, ML Brand, L TI INFERRING MECHANISMS FROM DOSE-RESPONSE CURVES SO METHODS IN ENZYMOLOGY, VOL 487: COMPUTER METHODS, PT C SE Methods in Enzymology LA English DT Review; Book Chapter ID GLUCOCORTICOID-RECEPTOR TRANSACTIVATION; INDUCTION PROPERTIES; SECONDARY MEDIATORS; HORMONE-BINDING; GENE INDUCTION; TRANSCRIPTION; SYSTEMS; REPRESSION; MODULATION; DOMAIN AB The steady state dose response curve of ligand-mediated gene induction usually appears to precisely follow a first-order Hill equation (Hill coefficient equal to 1). Additionally, various cofactors/reagents can affect both the potency and the maximum activity of gene induction in a gene-specific manner. Recently, we have developed a general theory for which an unspecified sequence of steps or reactions yields a first-order Hill dose response curve (FHDC) for plots of the final product versus initial agonist concentration. The theory requires only that individual reactions "dissociate" from the downstream reactions leading to the final product, which implies that intermediate complexes are weakly bound or exist only transiently. We show how the theory can be utilized to make predictions of previously unidentified mechanisms and the site of action of cofactors/reagents. The theory is general and can be applied to any biochemical reaction that has a FHDC. C1 [Chow, Carson C.; Ong, Karen M.] NIDDK, Lab Biol Modeling, CEB, NIH, Bethesda, MD 20892 USA. [Dougherty, Edward J.; Simons, S. Stoney, Jr.] NIDDK, Steroid Hormones Sect, CEB, NIH, Bethesda, MD USA. RP Chow, CC (reprint author), NIDDK, Lab Biol Modeling, CEB, NIH, Bethesda, MD 20892 USA. RI Chow, Carson/A-7970-2009; OI Dougherty, Edward/0000-0001-7664-9779 NR 22 TC 12 Z9 12 U1 0 U2 5 PU ELSEVIER ACADEMIC PRESS INC PI SAN DIEGO PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA SN 0076-6879 BN 978-0-12-381270-4 J9 METHOD ENZYMOL JI Methods Enzymol. PY 2011 BP 465 EP 483 DI 10.1016/S0076-6879(11)87016-3 PG 19 WC Biochemical Research Methods; Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA BTC96 UT WOS:000286532000016 ER PT S AU Samuels, Y Waldman, T AF Samuels, Yardena Waldman, Todd BE Rommel, C Vanhaesebroeck, B Vogt, PK TI Oncogenic Mutations of PIK3CA in Human Cancers SO PHOSPHOINOSITIDE 3-KINASE IN HEALTH AND DISEASE, VOL 2 SE Current Topics in Microbiology and Immunology LA English DT Review; Book Chapter ID SQUAMOUS-CELL CARCINOMA; MIDDLE-EASTERN POPULATION; ANAPLASTIC THYROID-CANCER; BREAST-CANCER; COLORECTAL CANCERS; GENE-MUTATIONS; HIGH-FREQUENCY; LUNG-CANCER; ENDOMETRIAL CARCINOMA; COLON-CANCER AB The involvement of the PIK3CA gene product p110 alpha, the catalytic subunit of phosphatidylinositol 3-kinase (PI3K), in human cancer has been suggested for over 15 years, and support for this proposal had been provided by both genetic and functional studies, including most recently the discovery of common activating missense mutations of PIK3CA in a wide variety of common human tumor types. This chapter will focus on the discovery of these mutations and describes their relevance to a wide range of common human tumor types. Of note, the identification and functional analysis of the PIK3CA gene are reviewed in other chapters in this book. However, a brief mention will be made here of its general properties as background to our focus on the discovery of its cancer-specific mutations. C1 [Samuels, Yardena] NHGRI, Canc Genet Branch, NIH, Bethesda, MD 20892 USA. [Waldman, Todd] Georgetown Univ, Sch Med, Lombardi Comprehens Canc Ctr, Dept Oncol, Washington, DC USA. RP Samuels, Y (reprint author), NHGRI, Canc Genet Branch, NIH, Bethesda, MD 20892 USA. EM samuelsy@mail.nih.gov FU Intramural NIH HHS [Z01 HG200337-01]; NCI NIH HHS [R01 CA115699, R01 CA115699-05, R01 CA115699-04] NR 140 TC 11 Z9 12 U1 1 U2 10 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0070-217X BN 978-3-642-14816-3 J9 CURR TOP MICROBIOL JI Curr.Top.Microbiol.Immunol. PY 2011 VL 347 BP 21 EP 41 DI 10.1007/82_2010_68 D2 10.1007/978-3-642-14816-3 PG 21 WC Oncology; Immunology; Medicine, Research & Experimental; Microbiology SC Oncology; Immunology; Research & Experimental Medicine; Microbiology GA BSJ47 UT WOS:000284609400002 PM 20535651 ER PT J AU Li, G Xie, HC Ning, H Citrin, D Kaushal, A Camphausen, K Miller, RW AF Li, Guang Xie, Huchen Ning, Holly Citrin, Deborah Kaushal, Aradhana Camphausen, Kevin Miller, Robert W. TI Correction of motion-induced misalignment in co-registered PET/CT and MRI (T1/T2/FLAIR) head images for stereotactic radiosurgery SO JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS LA English DT Article DE 3D volumetric image registration; co-registered PET/CT and MRI/MRI images; head motion; target delineation and localization; high-precision stereotactic radiosurgery (SRS) ID POSITRON-EMISSION-TOMOGRAPHY; ACCURACY; CT; SYSTEM; REGISTRATION; RADIOTHERAPY; ONCOLOGY; SCANNER; VOLUME; BRAIN AB The purpose was to evaluate and correct the co-registration of diagnostic PET/CT and MRI/MRI images for stereotactic radiosurgery (SRS) using 3D volumetric image registration (3DVIR). The 3DVIR utilizes the homogeneity of color distribution over a volumetric anatomical landmark as the registration criterion with submillimeter accuracy. Fifty-three PET/CT and MRI (T1, T2 and FLAIR) image sets of patients with brain lesions were acquired sequentially from a hybrid PET/CT or an MRI scanner with common diagnostic head holding devices. Twenty-five sets of head (18)F-FDG-PET/CT images were scanned over a 10-minute interval and 14 whole-body sets were scanned over a 30-minute interval. Fourteen sets of MRI images were acquired, and each 3-modal image set (T1, T2 and FLAIR) was scanned in sequence at time 0, similar to 5 and similar to 20 minutes. The misalignments in these "co-registered" images were evaluated and corrected using the 3DVIR. Using the head immobilization devices commonly found in diagnostic PET/CT and MRI/MRI imaging, 80%-100% of these "co-registered" images were identified as misaligned. For PET/CT, the magnitude of misalignment was 0.4 degrees +/- 0.5 degrees and 0.7 +/- 0.4 mm for 10-minute scans, and 0.8 degrees +/- 1.2 degrees and 2.7 +/- 1.7 mm for 30-minute scans. For MRI/MRI, the magnitude was 0.2 degrees +/- 0.4 degrees and 0.3 +/- 0.2 mm for 5-minute scan intervals, and 1.1 degrees +/- 0.7 degrees and 1.2 +/- 1.4 mm for 20-minute intervals. Small, but significant, misalignment is present in the co-registered diagnostic PET/CT and MRI/MRI images and can be corrected in SRS treatment planning using the volumetric image registration for improved target localization within the clinical error tolerance. C1 [Li, Guang; Xie, Huchen; Ning, Holly; Citrin, Deborah; Kaushal, Aradhana; Camphausen, Kevin; Miller, Robert W.] NCI, Radiat Oncol Branch, Clin Res Ctr, NIH, Bethesda, MD 20892 USA. RP Li, G (reprint author), Mem Sloan Kettering Canc Ctr, Dept Med Phys, Box 84,Room 112C,1275 York Ave, New York, NY 10065 USA. EM lig2@mskcc.org OI Li, Guang/0000-0002-9022-2883 NR 26 TC 1 Z9 1 U1 1 U2 2 PU MULTIMED INC PI TORONTO PA 66 MARTIN ST, TORONTO, ON L9T 2R2, CANADA SN 1526-9914 J9 J APPL CLIN MED PHYS JI J. Appl. Clin. Med. Phys PY 2011 VL 12 IS 1 BP 58 EP 67 PG 10 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 750MO UT WOS:000289551600007 ER PT J AU Hiranita, T Tanda, G Kopajtic, T Katz, J AF Hiranita, Takato Tanda, Gianluigi Kopajtic, Theresa Katz, Jonathan TI Cocaine (Coc) self administration (SA) induces the reinforcing effects of the selective sigma 1-receptor (sigma 1R) agonists SO JOURNAL OF PHARMACOLOGICAL SCIENCES LA English DT Meeting Abstract CT 84th Annual Meeting of the Japanese-Pharmacological-Society/11th Southeast Asian Western Pacific Regional Meeting of Pharmacologists CY MAR 22-24, 2011 CL Yokohama, JAPAN SP Japanese Pharmacolog Soc C1 [Hiranita, Takato; Tanda, Gianluigi; Kopajtic, Theresa; Katz, Jonathan] NIDA, Medicat Discovery Res Branch, IRP, NIH,DHHS,Biomed Res Ctr, Baltimore, MD 21224 USA. RI Hiranita, Takato/G-6567-2011; Tanda, Gianluigi/B-3318-2009 OI Tanda, Gianluigi/0000-0001-9526-9878 NR 0 TC 0 Z9 0 U1 0 U2 0 PU JAPANESE PHARMACOLOGICAL SOC PI KYOTO PA EDITORIAL OFF, KANTOHYA BLDG GOKOMACHI-EBISUGAWA NAKAGYO-KU, KYOTO, 604, JAPAN SN 1347-8613 J9 J PHARMACOL SCI JI J. Pharmacol. Sci. PY 2011 VL 115 SU 1 BP 147P EP 147P PG 1 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 743QU UT WOS:000289034600501 ER PT J AU Unno, T Inasaki, M Matsuyama, H Tanahashi, Y Kitazawa, T Yamada, M Wess, Y Komori, S AF Unno, Toshihiro Inasaki, Michiko Matsuyama, Hayato Tanahashi, Yasuyuki Kitazawa, Takio Yamada, Masahisa Wess, Yurgen Komori, Seiichi TI Role of M3 muscarinic receptor-coupled signalling molecule in the activation of muscarinic cation channels in mouse ileal smooth muscle cells SO JOURNAL OF PHARMACOLOGICAL SCIENCES LA English DT Meeting Abstract CT 84th Annual Meeting of the Japanese-Pharmacological-Society/11th Southeast Asian Western Pacific Regional Meeting of Pharmacologists CY MAR 22-24, 2011 CL Yokohama, JAPAN SP Japanese Pharmacolog Soc C1 [Unno, Toshihiro; Inasaki, Michiko; Matsuyama, Hayato; Komori, Seiichi] Gifu Univ, Dept Vet Med, Pharmacol Lab, Gifu 5011193, Japan. [Tanahashi, Yasuyuki] Kyoto Sangyo Univ, Dept Anim Med Sci, Kita Ku, Kyoto 6038555, Japan. [Kitazawa, Takio] Rakuno Gakuen Univ, Dept Pharmacol, Ebetsu, Hokkaido 0698501, Japan. [Yamada, Masahisa] Okinawa Inst Sci Tech, Common Resources Grp, Onna Son, Okonawa 9040412, Japan. [Wess, Yurgen] NIDDKD, Bioorgan Chem Lab, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU JAPANESE PHARMACOLOGICAL SOC PI KYOTO PA EDITORIAL OFF, KANTOHYA BLDG GOKOMACHI-EBISUGAWA NAKAGYO-KU, KYOTO, 604, JAPAN SN 1347-8613 J9 J PHARMACOL SCI JI J. Pharmacol. Sci. PY 2011 VL 115 SU 1 BP 217P EP 217P PG 1 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 743QU UT WOS:000289034601251 ER PT J AU Nemeth, A Stadler, K Jakus, J Vidoczy, T AF Nemeth, A. Stadler, K. Jakus, J. Vidoczy, T. TI KINETICS OF PEROXYNITRITE FORMATION AND DECAY IN DIABETIC RAT AORTA SO OXIDATION COMMUNICATIONS LA English DT Article DE superoxide; nitric oxide; superoxide dismutase (SOD); tyrosine; reaction mechanism ID NITRIC-OXIDE; SUPEROXIDE-DISMUTASE; TYROSINE NITRATION; BIOLOGICAL-SYSTEMS; RADICAL FORMATION; (NO)-N-CENTER-DOT; DECOMPOSITION; CONSUMPTION; CELLS; ONOO AB Detailed reaction mechanism compiled from literature was tested on diabetic rat aorta samples for which nitric oxide, superoxide formations and spin clearance rate were measured by electron paramagnetic resonance (EPR) method. The rate of superoxide formation was 1.0x10(-7) M s(-1). Kinetic calculations predicted ranges of nitric oxide formation rate and of nitric oxide, superoxide, peroxynitrite concentrations viable in the investigated biological entity. C1 [Nemeth, A.; Jakus, J.] Hungarian Acad Sci, Inst Biomol Chem, Chem Res Ctr, H-1025 Budapest, Hungary. [Stadler, K.] NIEHS, NIH, Res Triangle Pk, NC 27709 USA. [Vidoczy, T.] Hungarian Acad Sci, Inst Struct Chem, Chem Res Ctr, H-1025 Budapest, Hungary. RP Nemeth, A (reprint author), Hungarian Acad Sci, Inst Biomol Chem, Chem Res Ctr, 59-67 Pusztaszeri St, H-1025 Budapest, Hungary. EM anemeth@chemres.hu RI Vidoczy, Tamas/H-6177-2012 NR 30 TC 2 Z9 2 U1 0 U2 1 PU SCIBULCOM LTD PI SOFIA PA PO BOX 249, 1113 SOFIA, BULGARIA SN 0209-4541 J9 OXID COMMUN JI Oxid. Commun. PY 2011 VL 34 IS 1 BP 128 EP 135 PG 8 WC Chemistry, Multidisciplinary SC Chemistry GA 749FF UT WOS:000289448500018 ER PT J AU Munster, V Feldmann, H AF Munster, Vincent Feldmann, Heinz TI Ecology of Emerging Viruses: Bridging the Gap Between Field and Experimental Research SO ECOHEALTH LA English DT Meeting Abstract C1 [Munster, Vincent; Feldmann, Heinz] NIAID, Virol Lab, Rocky Mt Labs, Div Intramural Res,NIH, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1612-9202 J9 ECOHEALTH JI EcoHealth PY 2011 VL 7 SU 1 BP S68 EP S68 PG 1 WC Biodiversity Conservation; Ecology; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 728VB UT WOS:000287901500114 ER PT J AU Huebner, RB Kantor, LW AF Huebner, Robert B. Kantor, Lori Wolfgang TI Advances in Alcoholism Treatment SO ALCOHOL RESEARCH & HEALTH LA English DT Article DE Alcohol use disorders; alcohol dependence; alcoholism; treatment; treatment models; treatment research; treatment issues; cost-effectiveness; pharmacotherapy; medication therapy; behavior therapy; emerging technologies; co-treatment; 12-step-model; continuing care; health care delivery ID UNITED-STATES; DEPENDENCE; RECOVERY AB Researchers are working on numerous and varied approaches to improving the accessibility, quality, effectiveness, and cost-effectiveness of treatment for alcohol use disorders (AUDs). This overview article summarizes the approaches reviewed in this issue, including potential future developments for alcoholism treatment, such as medications development, behavioral therapy, advances in technology that are being used to improve treatment, integrated care of patients with AUDs and co-occurring disorders, the role of 12-step programs in the broader realm of treatment, treating patients with recurring and chronic alcohol dependence, strategies to close the gap between treatment need and treatment utilization, and how changes in the health care system may affect the delivery of treatment. This research will not only reveal new medications and behavioral therapies but also will contribute to new ways of approaching current treatment problems. C1 [Huebner, Robert B.] NIAAA, Div Treatment & Recovery Res, Rockville, MD 20852 USA. [Kantor, Lori Wolfgang] Alcohol Res & Hlth, Springfield, VA USA. RP Huebner, RB (reprint author), NIAAA, Div Treatment & Recovery Res, Rockville, MD 20852 USA. NR 7 TC 7 Z9 7 U1 2 U2 7 PU NATL INST ALCOHOL ABUSE ALCOHOLISM PI ROCKVILLE PA 6000 EXECUTIVE BLVD, ROCKVILLE, MD 20892-7003 USA SN 1535-7414 J9 ALCOHOL RES HEALTH JI Alcohol Res. Health PY 2011 VL 33 IS 4 BP 295 EP 299 PG 5 WC Substance Abuse SC Substance Abuse GA 731KO UT WOS:000288105600001 PM 23580014 ER PT J AU Xie, HC Liang, Y Lao, DQ Zhang, TY Ito, Y AF Xie Huichun Liang, Yong Lao, Deqiang Zhang, Tianyou Ito, Yoichiro TI PREPARATIVE SEPARATION OF HIGH-PURITY CORDYCEPIN FROM CORDYCEPS MILITARIS(L.) LINK BY HIGH-SPEED COUNTERCURRENT CHROMATOGRAPHY SO JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES LA English DT Article DE Cordyceps militaris(L; ) link; cordycepin; countercurrent chromatography; preparative chromatography ID PURIFICATION AB A high-speed counter-current chromatography (HSCCC) technique in a preparative scale has been applied to separate and purify cordycepin from the extract of Cordyceps militaris(L.) Link by a one-step separation. A high efficiency of HSCCC separation was achieved on a two-phase solvent system of n-hexane-n-butanol-methanol-water (23:80:30:155, v/v/v/v) by eluting the lower mobile phase at a flow rate of 2mL/min under a revolution speed of 850rpm. HSCCC separation of 216.2mg crude sample (contained cordycepin at 44.7% purity after 732 cation-exchange resin clean-up) yielded 64.8mg cordycepin with purity of 98.9% and 91.7% recovery. Identification of the target compound was performed by UV, IR, MS, 1H NMR, and 13C NMR. C1 [Xie Huichun; Liang, Yong; Lao, Deqiang] S China Normal Univ, Sch Chem & Environm, Guangzhou 510631, Guangdong, Peoples R China. [Zhang, Tianyou] Beijing Inst New Technol Applicat, Beijing, Peoples R China. [Ito, Yoichiro] NHLBI, Biochem & Biophys Ctr, NIH, Bethesda, MD 20892 USA. RP Liang, Y (reprint author), S China Normal Univ, Sch Chem & Environm, Guangzhou 510631, Guangdong, Peoples R China. EM liangy@scnu.edu.cn; itoy2@mail.nih.gov NR 14 TC 0 Z9 0 U1 1 U2 19 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1082-6076 J9 J LIQ CHROMATOGR R T JI J. Liq. Chromatogr. Relat. Technol. PY 2011 VL 34 IS 7 BP 491 EP 499 AR PII 935387120 DI 10.1080/10826076.2011.556965 PG 9 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 742QH UT WOS:000288959000001 ER PT J AU Friedman, A Danis, M AF Friedman, Alex Danis, Marion TI INTRANSITIVITY AND PRIORITY SETTING SO JOURNAL OF PHILOSOPHICAL RESEARCH LA English DT Article AB It is a basic and intuitive assumption that the relation of moral preference must be transitive-if A is overall morally preferable to B; and B is overall morally preferably to C; then, if our views are coherent, it better be the case that A is overall morally preferable to C. However, recent work by Temkin and Rachels has undermined that assumption by showing that common-sense ethical distributive principles that we are unlikely to give up generate intransitive sets of moral preferences. The consequences of this for resource allocation are profound-how can we come up with a just way of rationing limited resources if whatever course of action we adopt, there will be other alternatives that are morally preferable to it? However, regardless of the theoretical challenges, practical resource allocation decisions must be made every day! We explore an approach to dealing with some of the pragmatic aspects of the problem, even though the theoretical problem of intransitivity remains unsolved. We begin by considering whether the ways in which counterexamples to transitivity have (of necessity) been oversimplified actually contribute to the intractability of the problem by taking the possibilities of cost sharing, benefit splitting, and compensation (which are often available in real-life tradeoff situations) off the table. The proposal we end up suggesting does not rely on any assumptions or judgments about interpersonal aggregation, and so has a chance of allowing us to work around the most troubling kind of intransitivity. C1 [Friedman, Alex; Danis, Marion] NIH, Ctr Clin, Bethesda, MD 20892 USA. RP Friedman, A (reprint author), NIH, Ctr Clin, Bethesda, MD 20892 USA. NR 15 TC 1 Z9 1 U1 0 U2 1 PU PHILOSOPHY DOCUMENTATION CENTER PI CHARLOTTESVILLE PA PO BOX 7147, CHARLOTTESVILLE, VA 22906-7147 USA SN 1053-8364 J9 J PHILOS RES JI J. Philos. Res. PY 2011 VL 36 BP 173 EP 189 PG 17 WC Philosophy SC Philosophy GA 738GE UT WOS:000288627500010 ER PT J AU Conde-Agudelo, A Belizan, JM Diaz-Rossello, J AF Conde-Agudelo, A. Belizan, J. M. Diaz-Rossello, J. TI Kangaroo mother care to reduce morbidity and mortality in low birthweight infants SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS LA English DT Review DE Infant Mortality; Infant, Low Birth Weight; Infant Care [methods]; Infant, Newborn; Length of Stay; Physical Stimulation [methods]; Randomized Controlled Trials as Topic; Weight Gain; Humans ID SKIN-TO-SKIN; RANDOMIZED CONTROLLED-TRIAL; CONVENTIONAL INCUBATOR CARE; PRETERM INFANTS; TRADITIONAL CARE; NEONATAL DEATHS; UTTAR-PRADESH; CONTACT; GROWTH; ATTACHMENT AB Background Kangaroo mother care (KMC), originally defined as skin-to-skin contact between a mother and her newborn, frequent and exclusive or nearly exclusive breastfeeding, and early discharge from hospital, has been proposed as an alternative to conventional neonatal care for low birthweight (LBW) infants. Objectives To determine whether there is evidence to support the use of KMC in LBW infants as an alternative to conventional neonatal care. Search strategy The standard search strategy of the Cochrane Neonatal Group was used. This included searches of MEDLINE, EMBASE, LILACS, POPLINE, CINAHL databases (from inception to January 31, 2011), and the Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 1, 2011). In addition, we searched the web page of the Kangaroo Foundation, conference and symposia proceedings on KMC, and Google scholar. Selection criteria Randomized controlled trials comparing KMC versus conventional neonatal care, or early onset KMC (starting within 24 hours after birth) versus late onset KMC (starting after 24 hours after birth) in LBW infants. Data collection and analysis Data collection and analysis were performed according to the methods of the Cochrane Neonatal Review Group. Main results Sixteen studies, including 2518 infants, fulfilled inclusion criteria. Fourteen studies evaluated KMC in LBWinfants after stabilization, one evaluated KMC in LBW infants before stabilization, and one compared early onset KMC with late onset KMC in relatively stable LBW infants. Eleven studies evaluated intermittent KMC and five evaluated continuous KMC. At discharge or 40 -41 weeks' postmenstrual age, KMC was associated with a reduction in the risk of mortality (typical risk ratio (RR) 0.60, 95% confidence interval (CI) 0.39 to 0.93; seven trials, 1614 infants), nosocomial infection/sepsis (typical RR 0.42, 95% CI 0.24 to 0.73), hypothermia (typical RR 0.23, 95% CI 0.10 to 0.55), and length of hospital stay (typical mean difference 2.4 days, 95% CI 0.7 to 4.1). At latest follow up, KMC was associated with a decreased risk of mortality (typical RR 0.68, 95% CI 0.48 to 0.96; nine trials, 1952 infants) and severe infection/sepsis (typical RR 0.57, 95% CI 0.40 to 0.80). Moreover, KMC was found to increase some measures of infant growth, breastfeeding, and mother-infant attachment. Authors' conclusions The evidence from this updated review supports the use of KMC in LBWinfants as an alternative to conventional neonatal care mainly in resource-limited settings. Further information is required concerning effectiveness and safety of early onset continuous KMC in unstabilized LBW infants, long term neurodevelopmental outcomes, and costs of care. C1 [Conde-Agudelo, A.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Perinatol Res Branch, NIH, Dept Hlth & Human Serv, Detroit, MI USA. [Belizan, J. M.] Inst Clin Effectiveness & Hlth Policy IECS, Dept Mother & Child Hlth Res, Buenos Aires, DF, Argentina. [Diaz-Rossello, J.] Univ Hosp, Dept Neonatol, Montevideo, Uruguay. RP Conde-Agudelo, A (reprint author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Perinatol Res Branch, NIH, Dept Hlth & Human Serv, Detroit, MI USA. EM condeagu@hotmail.com FU Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development/National Institutes of Health/Department of Health and Human Services, Bethesda, MD and Detroit, MI, USA; Department of Neonatology, University Hospital, Montevideo, Uruguay; Department of Mother and Child Health Research, Institute for Clinical Effectiveness and Health Policy (IECS), Buenos Aires, Argentina FX (AC-A) Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development/National Institutes of Health/Department of Health and Human Services, Bethesda, MD and Detroit, MI, USA.; (JLD-R) Department of Neonatology, University Hospital, Montevideo, Uruguay.; (JMB) Department of Mother and Child Health Research, Institute for Clinical Effectiveness and Health Policy (IECS), Buenos Aires, Argentina. NR 75 TC 48 Z9 48 U1 5 U2 27 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1469-493X J9 COCHRANE DB SYST REV JI Cochrane Database Syst Rev. PY 2011 IS 3 AR CD002771 DI 10.1002/14651858.CD002771.pub2 PG 117 WC Medicine, General & Internal SC General & Internal Medicine GA 735ZB UT WOS:000288458200016 ER PT J AU Bard, KA Brent, L Lester, B Worobey, J Suomi, SJ AF Bard, Kim A. Brent, Linda Lester, Barry Worobey, John Suomi, Stephen J. TI Neurobehavioural Integrity of Chimpanzee Newborns: Comparisons Across Groups and Across Species Reveal Gene-Environment Interaction Effects SO INFANT AND CHILD DEVELOPMENT LA English DT Article DE ape; infant; epigenesis; social cognition; early development; NBAS; Brazelton test; emotion ID EFE PYGMY INFANTS; PAN-TROGLODYTES; YOUNG CHIMPANZEES; COGNITIVE-DEVELOPMENT; NEONATAL IMITATION; SOCIAL COGNITION; LATERAL BIAS; ORIENTATION; EPIGENESIS; GESTURES AB The aims of this article are to describe the neurobehavioural integrity of chimpanzee newborns, to investigate how early experiences affect the neurobehavioural organization of chimpanzees, and to explore species differences by comparing chimpanzee newborns with a group of typically developing human newborns. Neurobehavioural integrity related to orientation, motor performance, arousal, and state regulation of 55 chimpanzee (raised in four different settings) and 42 human newborns was measured with the Neonatal Behavioral Assessment Scale (NBAS), a semi-structured 25-min interactive assessment. Thirty-eight chimpanzees were tested every other day from birth, and the analyses revealed significant developmental changes in 19 of 27 NBAS scores. The cross-group and cross-species comparisons were conducted at 2 and 30 days of age. Among the four chimpanzee groups, significant differences were found in 23 of 24 NBAS scores. Surprisingly, the cross-species comparisons revealed that the human group was distinct in only 1 of the 25 NBAS scores (the human group had significantly less muscle tone than all the chimpanzee groups). The human group was indistinguishable from at least one of the chimpanzee groups in the remaining 24 of the 25 NBAS scores. The results of this study support the conclusion that the interplay between genes and environment, rather than genes alone or environment alone, accounts for phenotypic expressions of newborn neurobehavioural integrity in hominids. Copyright (C) 2010 John Wiley & Sons, Ltd. C1 [Bard, Kim A.] Univ Portsmouth, Ctr Study Emot, Dept Psychol, Portsmouth PO1 2DY, Hants, England. [Brent, Linda] ChimpHaven, Keithville, LA USA. [Lester, Barry] Brown Univ, Warren Alpert Med Sch, Women & Infants Hosp, Providence, RI USA. [Worobey, John] Rutgers State Univ, Dept Nutr Sci, Piscataway, NJ 08855 USA. [Suomi, Stephen J.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, DHHS, Bethesda, MD USA. RP Bard, KA (reprint author), Univ Portsmouth, Ctr Study Emot, Dept Psychol, King Henry Bldg, Portsmouth PO1 2DY, Hants, England. EM kim.bard@port.ac.uk FU NCRR NIH HHS [U42 RR003591, R24 RR006158, P51 RR000165]; NICHD NIH HHS [F32 HD007105, R01 HD021013, T32 HD007105] NR 100 TC 6 Z9 6 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1522-7227 J9 INFANT CHILD DEV JI Infant Child Dev. PD JAN-FEB PY 2011 VL 20 IS 1 SI SI BP 47 EP 93 DI 10.1002/icd.686 PG 47 WC Psychology, Developmental SC Psychology GA 721TN UT WOS:000287378200005 PM 25110465 ER PT J AU Ozarslan, E Shemesh, N Koay, CG Cohen, Y Basser, PJ AF Oezarslan, Evren Shemesh, Noam Koay, Cheng Guan Cohen, Yoram Basser, Peter J. TI Nuclear magnetic resonance characterization of general compartment size distributions SO NEW JOURNAL OF PHYSICS LA English DT Article ID SELF-DIFFUSION COEFFICIENT; RESTRICTED DIFFUSION; FIELD-GRADIENT; EMULSION SYSTEMS; SPIN ECHOES; PFG-NMR; WATER; TIME; PROPAGATOR; MRI AB The influence of molecular diffusion on the nuclear magnetic resonance (NMR) signal can be exploited to estimate compartment size distributions in heterogeneous specimens. Theoretical relationships between the NMR signal intensity at long diffusion times and the moments of a general distribution of isolated pores with characteristic shapes (planar, cylindrical or spherical) are established. A numerical method based on expressing a general diffusion-attenuated NMR signal profile in a series of complete orthogonal basis functions is introduced and subsequently used to estimate the moments of the compartment size distribution. The results on simulated and real data obtained from controlled water-filled microcapillaries demonstrate the power of the approach to create contrast based not only on the mean of the compartment size but also on its variance. The technique can be used to address a variety of problems such as characterizing distributions of droplet sizes in emulsions and of apparent axon diameters in nerve fascicles. C1 [Oezarslan, Evren; Koay, Cheng Guan; Basser, Peter J.] NICHD, Sect Tissue Biophys & Biomimet, NIH, Bethesda, MD 20892 USA. [Shemesh, Noam; Cohen, Yoram] Tel Aviv Univ, Raymond & Beverly Sackler Fac Exact Sci, Sch Chem, IL-69978 Ramat Aviv, Israel. RP Ozarslan, E (reprint author), NICHD, Sect Tissue Biophys & Biomimet, NIH, 13 South Dr, Bethesda, MD 20892 USA. EM evren@helix.nih.gov RI Ozarslan, Evren/B-4858-2013; Basser, Peter/H-5477-2011; OI Ozarslan, Evren/0000-0003-0859-1311; Shemesh, Noam/0000-0001-6681-5876 FU Eunice Kennedy Shriver National Institute of Child Health and Human Development FX This work was supported by the Intramural Research Program of Eunice Kennedy Shriver National Institute of Child Health and Human Development. NR 38 TC 9 Z9 9 U1 0 U2 12 PU IOP PUBLISHING LTD PI BRISTOL PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND SN 1367-2630 J9 NEW J PHYS JI New J. Phys. PD JAN PY 2011 VL 13 AR 015010 DI 10.1088/1367-2630/13/1/015010 PG 17 WC Physics, Multidisciplinary SC Physics GA 741YK UT WOS:000288903600054 PM 21709780 ER PT J AU Yuan, M Xu, JF Yang, YN Zheng, G AF Yuan, Min Xu, Jinfeng Yang, Yaning Zheng, Gang TI A robust test for multi-ordered 2 x J ordinal contingency tables SO STATISTICS AND ITS INTERFACE LA English DT Article DE Efficiency robustness; Minimum p-values; Ordered categorical data; Scoring; Trend tests; Two-locus model ID CASE-CONTROL ASSOCIATION; GENOME-WIDE SCAN; CATEGORICAL-DATA; TREND TESTS; MACULAR DEGENERATION; SAMPLE-SIZE; MODELS; DISEASE; SCORES; POLYMORPHISM AB Pearson's chi-square test and the Cochran-Armitage trend test are commonly used in the analysis of 2 x J contingency tables. When the J columns are nominal, Pearson's test should be considered. On the other hand, when the J columns are ordinal and the ordering is well defined, the trend test should be used. In practice, however, the columns are often ordered but the ordering may not be uniquely defined, especially the J categories may be ordered in multiple ways according to several different factors. We assume that the columns could be either singly or multi-ordered, either being scientifically plausible, and consequently different scores could be assigned to the columns by the different ordering systems. Then the trend test, if applied, may lose substantial power when the orderings are misspecified. To guard against misspecifications of the scores for the columns, we propose a robust test by combining strengths of both Pearson's test and the trend test. In the trend test, we allow several different score specifications according to different ordering criteria and the scores are chosen to be robust enough. Extensive simulation studies demonstrate the efficiency robustness of the proposed approach. The proposed method is applied to two data sets from the Genetic Association Workshop 15 and an experiment on the use of sulfones and streptomycin drugs in the treatment of leprosy. C1 [Zheng, Gang] NHLBI, Off Biostat Res, DPPS, Bethesda, MD 20892 USA. [Yang, Yaning] Univ Sci & Technol China, Dept Stat & Finance, Hefei 230026, Peoples R China. [Xu, Jinfeng] Natl Univ Singapore, Dept Stat & Appl Probabil, Singapore 117546, Singapore. [Yuan, Min] Fudan Univ, Sch Publ Hlth, Shanghai 200032, Peoples R China. RP Zheng, G (reprint author), NHLBI, Off Biostat Res, DPPS, Bldg 10, Bethesda, MD 20892 USA. EM myuan@fudan.edu.cn; st.axj@nus.edu.sg; ynyang@ustc.edu.cn; zhengg@nhlbi.nih.gov FU China NSF; NUS [R155-000-075-112]; GAW grant [R01 GM031575] FX The work of Y. Yang is supported by China NSF Grant. The work of J. Xu is supported by NUS grant R155-000-075-112. We would like to thank both reviewers, and the editors for helpful comments and suggestions which improved our presentation. The use of GAW data was approved by the GAW grant, R01 GM031575. NR 31 TC 0 Z9 0 U1 1 U2 4 PU INT PRESS BOSTON, INC PI SOMERVILLE PA PO BOX 43502, SOMERVILLE, MA 02143 USA SN 1938-7989 J9 STAT INTERFACE JI Stat. Interface PY 2011 VL 4 IS 1 BP 1 EP 10 PG 10 WC Mathematical & Computational Biology; Mathematics, Interdisciplinary Applications SC Mathematical & Computational Biology; Mathematics GA 738ZS UT WOS:000288681800001 ER PT J AU Zhang, H Ahn, JY Yu, K AF Zhang, Hong Ahn, Jiyoung Yu, Kai TI Comparing statistical methods for removing seasonal variation from vitamin D measurements in case-control studies SO STATISTICS AND ITS INTERFACE LA English DT Article DE 25-hydroxy vitamin D; Partial linear model; Locally weighted polynomial regression; Penalized regression splines; Prostate cancer; Seasonal pattern; Sine curve ID LOCALLY WEIGHTED REGRESSION AB Vitamin D deficiency has been shown to be associated with multiple clinical outcomes, including osteoporosis, multiple sclerosis and colorectal cancer. In studies of vitamin D effect on disease outcome, vitamin D status is usually measured by a serum biomarker, namely 25-hydroxy vitamin D [25(OH)D]. Since the circulating 25(OH)D concentration varies from season to season and not all blood samples are collected at the same time, the disease-vitamin D relationship can be obscured if the seasonal variation is not adjusted properly. In the literature, a two-step procedure is usually adopted, with the vitamin D level adjusted for the seasonal variation being obtained in the first step, and the effect of vitamin D being assessed based on the adjusted vitamin D level at the second step. This two-step method can generate misleading results as the estimation variance arising from the first step is not taken into account in the second step analysis. We consider three alternative procedures that unify the two steps into a single model. We conduct an extensive simulation study to evaluate the performance of these methods and demonstrate their applications in a study of 25(OH)D effect on prostate cancer risk. C1 [Zhang, Hong; Yu, Kai] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA. [Zhang, Hong] Fudan Univ, Inst Biostat, Shanghai, Peoples R China. [Ahn, Jiyoung] NYU, Dept Environm Med, Sch Med, Div Epidemiol, New York, NY 10016 USA. RP Yu, K (reprint author), NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA. EM zhanghfd@fudan.edu.cn; jiyoung.ahn@nyumc.org; yuka@mail.nih.gov FU NIH; National Cancer Institute FX We thank B. J. Stone for her editorial help. This research utilized the high-performance computational capabilities of the Biowulf PC/Linux cluster at the National Institutes of Health, Bethesda, Maryland, USA (http://biowulf.nih.gov). The work of K. Yu and H. Zhang was supported in part by the Intramural Program of the NIH and the National Cancer Institute. NR 14 TC 1 Z9 1 U1 0 U2 5 PU INT PRESS BOSTON, INC PI SOMERVILLE PA PO BOX 43502, SOMERVILLE, MA 02143 USA SN 1938-7989 J9 STAT INTERFACE JI Stat. Interface PY 2011 VL 4 IS 1 BP 85 EP 93 PG 9 WC Mathematical & Computational Biology; Mathematics, Interdisciplinary Applications SC Mathematical & Computational Biology; Mathematics GA 738ZS UT WOS:000288681800009 PM 24089626 ER PT J AU Yuan, A Chen, GJ Xiong, JA He, WQ Jin, W Rotimi, C AF Yuan, Ao Chen, Guanjie Xiong, Juan He, Wenqing Jin, Wen Rotimi, Charles TI Bayesian-frequentist hybrid model with application to the analysis of gene copy number changes SO JOURNAL OF APPLIED STATISTICS LA English DT Article DE Bayesian; gene copy number; frequentist; hybrid model; prior information ID COMPARATIVE GENOMIC HYBRIDIZATION; ARRAY-CGH DATA; MAXIMUM-LIKELIHOOD; LUNG-CANCER; MICROARRAYS; ALGORITHM; REGRESSION; PROGRAM; TUMORS AB Gene copy number (GCN) changes are common characteristics of many genetic diseases. Comparative genomic hybridization (CGH) is a new technology widely used today to screen the GCN changes in mutant cells with high resolution genome-wide. Statistical methods for analyzing such CGH data have been evolving. Existing methods are either frequentist's or full Bayesian. The former often has computational advantage, while the latter can incorporate prior information into the model, but could be misleading when one does not have sound prior information. In an attempt to take full advantages of both approaches, we develop a Bayesian-frequentist hybrid approach, in which a subset of the model parameters is inferred by the Bayesian method, while the rest parameters by the frequentist's. This new hybrid approach provides advantages over those of the Bayesian or frequentist's method used alone. This is especially the case when sound prior information is available on part of the parameters, and the sample size is relatively small. Spatial dependence and false discovery rate are also discussed, and the parameter estimation is efficient. As an illustration, we used the proposed hybrid approach to analyze a real CGH data. C1 [Yuan, Ao] Howard Univ, Natl Human Genome Ctr, Washington, DC 20059 USA. [Chen, Guanjie; Rotimi, Charles] NHGRI, Ctr Res Genom & Global Hlth, NIH, Bethesda, MD 20892 USA. [Xiong, Juan; He, Wenqing] Univ Western Ontario, Dept Stat & Actuarial Sci, London, ON, Canada. [Jin, Wen] Suizhou Cent Hosp, Suizhou 441300, Hubei, Peoples R China. RP Yuan, A (reprint author), Howard Univ, Natl Human Genome Ctr, Washington, DC 20059 USA. EM yuanao@hotmail.com FU National Center for Research Resources at NIH [2G12RR003048]; Center for Research on Genomics and Global Health (CRGGH) at NHGRI/NIH FX This work is supported in part by the National Center for Research Resources at NIH grant 2G12RR003048, and by the Center for Research on Genomics and Global Health (CRGGH) at NHGRI/NIH. NR 35 TC 2 Z9 2 U1 0 U2 0 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0266-4763 J9 J APPL STAT JI J. Appl. Stat. PY 2011 VL 38 IS 5 BP 987 EP 1005 DI 10.1080/02664761003692449 PG 19 WC Statistics & Probability SC Mathematics GA 734WX UT WOS:000288373500010 PM 24014930 ER PT J AU Pearson, LN Kusanovic, JP Romero, R Strauss, JF Shriver, MD AF Pearson, Laurel N. Kusanovic, Juan Pedro Romero, Roberto Strauss, Jerome F., III Shriver, Mark D. TI Using tests for signatures of selection to validate and prioritize admixture mapping results SO AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY LA English DT Meeting Abstract CT 80th Annual Meeting of the American-Association-of-Physical-Anthropologists CY APR 11-16, 2011 CL Minneapolis, MN SP Amer Assoc Phys Anthropol C1 [Pearson, Laurel N.; Shriver, Mark D.] Penn State Univ, Dept Anthropol, University Pk, PA 16802 USA. [Kusanovic, Juan Pedro; Romero, Roberto] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Perinatol Res Branch, NIH, Bethesda, MD USA. [Strauss, Jerome F., III] Virginia Commonwealth Univ, Sch Med, Richmond, VA 23284 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0002-9483 J9 AM J PHYS ANTHROPOL JI Am. J. Phys. Anthropol. PY 2011 VL 144 SU 52 BP 236 EP 236 PG 1 WC Anthropology; Evolutionary Biology SC Anthropology; Evolutionary Biology GA 730LE UT WOS:000288034000643 ER PT J AU Schwandt, ML Nash, LT Marzke, MW AF Schwandt, Melanie L. Nash, Leanne T. Marzke, Mary W. TI Growth, behavior, and morphology: lessons from chimpanzees. SO AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY LA English DT Meeting Abstract CT 80th Annual Meeting of the American-Association-of-Physical-Anthropologists CY APR 11-16, 2011 CL Minneapolis, MN SP Amer Assoc Phys Anthropol C1 [Schwandt, Melanie L.] NIH, Bethesda, MD 20892 USA. [Nash, Leanne T.; Marzke, Mary W.] Arizona State Univ, Sch Human Evolut & Social Change, Tempe, AZ USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0002-9483 J9 AM J PHYS ANTHROPOL JI Am. J. Phys. Anthropol. PY 2011 VL 144 SU 52 BP 267 EP 267 PG 1 WC Anthropology; Evolutionary Biology SC Anthropology; Evolutionary Biology GA 730LE UT WOS:000288034000760 ER PT J AU Li, Y Graubard, BI DiGaetano, R AF Li, Yan Graubard, Barry I. DiGaetano, Ralph TI Weighting methods for population-based case-control studies with complex sampling SO JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES C-APPLIED STATISTICS LA English DT Article DE Analysis of survey data; Complex survey; Frequency matching; Post-stratification ID STRATIFIED CASE-CONTROL; LOGISTIC-REGRESSION; MAXIMUM-LIKELIHOOD; MODELS AB Complex sample designs, involving stratified and/or multistage sampling with sample weighting, along with frequency matching, are used to select controls or cases for case-control studies. Examples that motivated this paper are the Kaposi sarcoma case-control study that was conducted in Sicily and the US kidney cancer case-control study. Survey design-based approaches can be inefficient for the analysis of case-control studies with frequency matching. We propose a weighting method that post-stratifies control sample weights to the estimated population distribution of the matching variables among cases. This weighting maintains the efficiency of frequency matching. The method proposed is evaluated by using simulation studies and is applied to the two case-control studies. C1 [Li, Yan] Univ Texas Arlington, Dept Math, Arlington, TX 76019 USA. [Li, Yan; Graubard, Barry I.] NCI, Bethesda, MD 20892 USA. [DiGaetano, Ralph] WESTAT Corp, Rockville, MD 20850 USA. RP Li, Y (reprint author), Univ Texas Arlington, Dept Math, Room 438,Pickard Hall, Arlington, TX 76019 USA. EM liyanna@uta.edu NR 33 TC 9 Z9 9 U1 2 U2 8 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0035-9254 J9 J R STAT SOC C-APPL JI J. R. Stat. Soc. Ser. C-Appl. Stat. PY 2011 VL 60 BP 165 EP 185 DI 10.1111/j.1467-9876.2010.00731.x PN 2 PG 21 WC Statistics & Probability SC Mathematics GA 730EX UT WOS:000288017300002 ER PT J AU Phillips, KA Epstein, DH Vahabzadeh, M Lin, JL Preston, KL AF Phillips, K. A. Epstein, D. H. Vahabzadeh, M. Lin, J. L. Preston, K. L. TI Hour-by-Hour Cocaine Use Patterns and the Relationship to Work Status and Structure SO SUBSTANCE ABUSE LA English DT Meeting Abstract C1 [Phillips, K. A.; Epstein, D. H.; Preston, K. L.] Natl Inst Drug Abuse, Treatment Sect, Intramural Res Program, NIH, Bethesda, MD USA. [Vahabzadeh, M.; Lin, J. L.] Natl Inst Drug Abuse, Biomed Informat Sect, Intramural Res Program, NIH, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0889-7077 J9 SUBST ABUS JI Subst. Abus. PY 2011 VL 32 IS 1 BP 56 EP 56 PG 1 WC Substance Abuse SC Substance Abuse GA 717GE UT WOS:000287030800028 ER PT J AU Li, H He, JT Liu, Q Huo, ZH Liang, S Liang, Y Ito, Y AF Li, Hang He, Junting Liu, Qin Huo, Zhaohui Liang, Si Liang, Yong Ito, Yoichiro TI Simultaneous Determination of Hydrochlorothiazide and Reserpine in Human Urine by LC with a Simple Pre-Treatment SO CHROMATOGRAPHIA LA English DT Article DE Column liquid chromatography; Sample pre-treatment; Hydrochlorothiazide and reserpine in urine ID CHROMATOGRAPHY/TANDEM MASS-SPECTROMETRY; HUMAN PLASMA; LIQUID-CHROMATOGRAPHY; SPECTROFLUOROMETRIC DETERMINATION; TABLETS; HPLC AB A simple, selective and sensitive reversed-phase liquid chromatography method for simultaneous analysis of hydrochlorothiazide and reserpine in human urine was developed and subjected to primary pharmacokinetic study. After a simple protein precipitation using methanol and extraction with ethyl acetate, the analytes were separated on an Elite C(18) column at a flow rate of 0.8 mL min(-1). The mobile phase was composed of acetonitrile (A) and 0.2% ammonium chloride solution (B) for a gradient elution starting at A:B at 30:70, v/v for 0-6 min, linearly raising the percent of A from 30 to 50% (6-9 min) and ending at 50:50, v/v (9-25 min). The standard curves were linear over the range of 0.05-20 mu g mL(-1) for hydrochlorothiazide and 0.02-5.0 mu g mL(-1) for reserpine, respectively (r > 0.999). The limit of detection (LOD) and the limit of quantification (LOQ) were 5.5 and 18.2 ng mL(-1) for hydrochlorothiazide, and 7.1 and 23.6 ng mL(-1) for reserpine, respectively. The recoveries for both analytes were above 89 +/- A 1.35%. The intra-day and inter-day precision for hydrochlorothiazide were less than 1.91 and 1.38%, and those for reserpine were below 1.61 and 2.64%, respectively. The method indicated good performance in terms of specificity, linearity, detection and quantification limits, precision and accuracy, and was employed successfully for the simultaneous determination of hydrochlorothiazide and reserpine in human urine samples. C1 [Li, Hang; He, Junting; Liu, Qin; Huo, Zhaohui; Liang, Si; Liang, Yong] S China Normal Univ, Inst Analyt Chem, Sch Chem & Environm, Guangzhou 510006, Guangdong, Peoples R China. [Ito, Yoichiro] NHLBI, Bioseparat Technol Lab, Biochem & Biophys Ctr, NIH, Bethesda, MD 20892 USA. RP Liang, Y (reprint author), S China Normal Univ, Inst Analyt Chem, Sch Chem & Environm, Guangzhou 510006, Guangdong, Peoples R China. EM liangy@scnu.edu.cn FU Intramural NIH HHS [Z99 HL999999] NR 17 TC 5 Z9 6 U1 0 U2 9 PU VIEWEG PI WIESBADEN PA ABRAHAM-LINCOLN-STRABE 46, POSTFACH 15 47, D-65005 WIESBADEN, GERMANY SN 0009-5893 J9 CHROMATOGRAPHIA JI Chromatographia PD JAN PY 2011 VL 73 IS 1-2 BP 171 EP 175 DI 10.1007/s10337-010-1821-5 PG 5 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 712MI UT WOS:000286670500024 PM 21297934 ER PT J AU Liu, XD Sun, LG Li, D Wang, YH AF Liu, Xiaodong Sun, Liguang Li, Dan Wang, Yuhong TI Rare earth elements in the ornithogenic sediments from the Maritime Antarctic: A potential new palaeoecology proxy SO GEOCHEMICAL JOURNAL LA English DT Article DE Antarctica; ornithogenic sediments; rare earth elements; palaeoecology; penguin population ID ABANDONED PENGUIN COLONIES; KING-GEORGE-ISLAND; EAST ANTARCTICA; LAKE-SEDIMENTS; CLIMATE-CHANGE; LATE-HOLOCENE; PENINSULA; GEOCHEMISTRY; RECORD; ADELIE AB The ornithogenic sediments in the maritime Antarctic are good archives for studying the changes of historical penguin population. Rare earth elements (REEs) along with biological and lithophile elements in two lacustrine sediment cores (Y2 and Y4) influenced by penguin droppings were analyzed with the aim of evaluating their potential as a new palaeoecological proxy. The relative concentrations of REEs in the two cores show dramatic changes, and the average REE contents are 71.21 +/- 11.56 (n = 37) and 37.18 +/- 10.64 (n = 18) for Y2 and Y4, respectively. The REE light/heavy content ratios (L/H) are 4.48 +/- 0.59 for Y2 and 4.70 +/- 0.62 for Y4, very close to the mean ratio of four pure guano samples. The chondrite-normalized REE patterns in the Y2 and Y4 sediments significantly influenced by penguin droppings are characteristic of more fractionation, obviously negative Ce anomalies and positive Er anomalies, likely imprinting the REE signal of guano input. The total REE concentration has a statistically significant negative correlation with the levels of guano-derived bio- elements and a positive correlation with the levels of Sc and Al mainly originated from weathered soils. The calculated proportion of guano-derived REE based on two-member mixing equation has a change pattern consistent with that of the historical penguin population size, previously reconstructed from bio-element concentrations in the sediments. These results suggest that the non-crustal signature of REE in the ornithogenic sediments may provide a new palaeoecological proxy for studying the palaeoecological processes of Antarctic penguins on a large time scale. C1 [Liu, Xiaodong; Sun, Liguang; Li, Dan] Univ Sci & Technol China, Inst Polar Environm, Hefei 230026, Anhui, Peoples R China. [Wang, Yuhong] NIH, Bethesda, MD 20892 USA. RP Liu, XD (reprint author), Univ Sci & Technol China, Inst Polar Environm, Hefei 230026, Anhui, Peoples R China. EM ycx@ustc.edu.cn FU Polar Office of National Oceanic Bureau of China; National Natural Science Foundation [0876096, 41076123, 40606003, 40730107]; CAAA [20070202]; SOA Key Laboratory for Polar Science [KP2007002]; CAS FX We would like to thank Polar Office of National Oceanic Bureau of China for support and assistance. This study was supported by the National Natural Science Foundation (Grant Nos. 40876096, 41076123, 40606003 and 40730107), the young fund for strategetic research of Chinese polar sciences from CAAA (No. 20070202), open research fund from SOA Key Laboratory for Polar Science (KP2007002) and special fund for excellent Ph.D. Thesis of CAS. We especially appreciate three anonymous reviewers for their critical reviews and careful corrections on this manuscript. NR 48 TC 5 Z9 6 U1 4 U2 17 PU GEOCHEMICAL SOC JAPAN PI TOKYO PA 358-5 YAMABUKI-CHO, SHINJUKU-KU, TOKYO, 162-0801, JAPAN SN 0016-7002 EI 1880-5973 J9 GEOCHEM J JI Geochem. J. PY 2011 VL 45 IS 1 BP 15 EP 26 PG 12 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 728QY UT WOS:000287890800002 ER PT J AU Specht, A Fiske, L Erger, K Cossette, T Verstegen, J Campbell-Thompson, M Struck, MB Lee, YM Chou, JY Byrne, BJ Correia, CE Mah, CS Weinstein, DA Conlon, TJ AF Specht, Andrew Fiske, Laurie Erger, Kirsten Cossette, Travis Verstegen, John Campbell-Thompson, Martha Struck, Maggie B. Lee, Young Mok Chou, Janice Y. Byrne, Barry J. Correia, Catherine E. Mah, Cathryn S. Weinstein, David A. Conlon, Thomas J. TI Glycogen Storage Disease Type Ia in Canines: A Model for Human Metabolic and Genetic Liver Disease SO JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY LA English DT Review ID UNCOOKED CORNSTARCH; GLUCOSE-6-PHOSPHATASE GENE; CONTINUOUS GLUCOSE; CLINICAL COURSE; MUTATIONS; THERAPY; 1A; MANAGEMENT; GROWTH; IDENTIFICATION AB A canine model of Glycogen storage disease type Ia (GSDIa) is described. Affected dogs are homozygous for a previously described M121I mutation resulting in a deficiency of glucose-6-phosphatase-alpha. Metabolic, clinicopathologic, pathologic, and clinical manifestations of GSDIa observed in this model are described and compared to those observed in humans. The canine model shows more complete recapitulation of the clinical manifestations seen in humans including "lactic acidosis", larger size, and longer lifespan compared to other animal models. Use of this model in preclinical trials of gene therapy is described and briefly compared to the murine model. Although the canine model offers a number of advantages for evaluating potential therapies for GSDIa, there are also some significant challenges involved in its use. Despite these challenges, the canine model of GSDIa should continue to provide valuable information about the potential for generating curative therapies for GSDIa as well as other genetic hepatic diseases. C1 [Erger, Kirsten; Cossette, Travis; Byrne, Barry J.; Mah, Cathryn S.; Conlon, Thomas J.] Univ Florida, Powell Gene Therapy Ctr, Gainesville, FL 32610 USA. [Specht, Andrew] Univ Florida, Dept Small Anim Clin Sci, Gainesville, FL 32610 USA. [Fiske, Laurie; Correia, Catherine E.; Weinstein, David A.] Univ Florida, Div Pediat Endocrinol, Dept Pediat, Glycogen Storage Dis Program, Gainesville, FL 32610 USA. [Verstegen, John] Univ Florida, Dept Large Anim Clin Sci, Gainesville, FL 32610 USA. [Campbell-Thompson, Martha] Univ Florida, Dept Pathol Immunol & Lab Med, Gainesville, FL 32610 USA. [Struck, Maggie B.] Univ Florida, Anim Care Serv, Gainesville, FL 32610 USA. [Lee, Young Mok; Chou, Janice Y.] NICHHD, Sect Cellular Differentiat, PDEGEN, NIH, Bethesda, MD 20892 USA. [Byrne, Barry J.; Mah, Cathryn S.] Univ Florida, Div Cellular & Mol Therapy, Dept Pediat, Gainesville, FL 32610 USA. [Conlon, Thomas J.] Univ Florida, Dept Pediat, Coll Med, Gainesville, FL 32610 USA. RP Conlon, TJ (reprint author), Univ Florida, Powell Gene Therapy Ctr, Gainesville, FL 32610 USA. EM conlon@peds.ufl.edu OI Campbell-Thompson, Martha/0000-0001-6878-1235 FU Children's Fund for Glycogen Storage Disease Research; Children's Miracle Network; National Institutes of Health [NHLBI P01 HL59412-06, NIDDK P01 DK58327-03]; Scott Miller Glycogen Storage Disease Program Fund; Matthew Ehrman GSD Research Fund; Type Ib Glycogen Storage Disease Fund; Jonah Pournazarian Type Ib GSD Fund; Green Family Fund for GSD Research; HLH Fund; Canadian Fund for the Cure of GSD FX The authors gratefully acknowledge the UF GSD Puppy Care Team and the University of Florida Animal Care Services and College of Veterinary Medicine Veterinary Staff for their assistance in animal care; they also acknowledge the University of Florida Molecular Pathology Core; and the University of Florida Powell Gene Therapy Center Toxicology Core. This work was supported by Grants from the Children's Fund for Glycogen Storage Disease Research, the Children's Miracle Network, and the National Institutes of Health (nos. NHLBI P01 HL59412-06, NIDDK P01 DK58327-03). Additional philanthropic support was provided from the Scott Miller Glycogen Storage Disease Program Fund, Matthew Ehrman GSD Research Fund, the Type Ib Glycogen Storage Disease Fund, the Jonah Pournazarian Type Ib GSD Fund, Green Family Fund for GSD Research, HLH Fund, and the Canadian Fund for the Cure of GSD. B. J. Byrne the Johns Hopkins University, and the University of Florida could be entitled to patent royalties for inventions described in this paper. D. A. Weinstein and T. Cossette share senior authorship for this work. NR 40 TC 3 Z9 3 U1 0 U2 1 PU HINDAWI PUBLISHING CORPORATION PI NEW YORK PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA SN 1110-7243 J9 J BIOMED BIOTECHNOL JI J. Biomed. Biotechnol. PY 2011 AR 646257 DI 10.1155/2011/646257 PG 9 WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental SC Biotechnology & Applied Microbiology; Research & Experimental Medicine GA 728PC UT WOS:000287885000001 ER PT J AU Jia, L Zhao, YL Liang, XJ AF Jia, Lee Zhao, Yuliang Liang, Xing-Jie TI Fast evolving nanotechnology and relevant programs and entities in China SO NANO TODAY LA English DT Article DE Nanotechnology; Nanomaterials; Nanoscience; Nanosafety ID SCIENCE; RUSSIA AB In recent years, facing serious global competition, the Chinese government has focused on accelerating the growth of the advanced technology sector including nanotechnology in order to lift the country's status from manufacturing raw materials and goods up to innovation technology, information economy and green efficient energy. With trillions in tangible monetary reserves, the government has substantially increased its investment in nanotechnology through several major initiatives. These measures comprise tax incentives and low rents for new facilities within economic development parks to stimulate the growth of new nanotechnology-related companies and attract foreign investment. This article outlines some of the current nanotechnology businesses, programs and markets across China, including its technology focus, collaborations, geography, and funding from central and local governments and from the private sector. Efforts are being made in China to increase the number and quality of nanotechnology-related publications and patents, and to pursue industrial-scale production of nanomaterials with the intention of opening up opportunities for new businesses to sprout and grow. Watching China's shift to a nation that promotes innovation will be an exciting time for the global nanotechnology community. It is hoped that R&D and commercial applications of nanomaterials and nanotechnology will provide new impetus for faltering economies. Published by Elsevier Ltd. C1 [Jia, Lee] NCI, NIH, Rockville, MD 20852 USA. [Zhao, Yuliang; Liang, Xing-Jie] Chinese Acad Sci, Natl Ctr Nanosci & Technol China, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China. RP Jia, L (reprint author), Dev Therapeut Program, Execut Plaza N,Room 8042,6130 Execut Blvd,MSC 745, Rockville, MD 20852 USA. EM jiale@mail.nih.gov NR 16 TC 11 Z9 12 U1 2 U2 28 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1748-0132 J9 NANO TODAY JI Nano Today PY 2011 VL 6 IS 1 BP 6 EP 11 DI 10.1016/j.nantod.2010.11.003 PG 6 WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 729NT UT WOS:000287958200005 ER PT J AU Rahbar, A Rivers, R Boja, E Kinsinger, C Mesri, M Hiltke, T Rodriguez, H AF Rahbar, Amir Rivers, Robert Boja, Emily Kinsinger, Christopher Mesri, Mehdi Hiltke, Tara Rodriguez, Henry TI Realizing individualized medicine: the road to translating proteomics from the laboratory to the clinic SO PERSONALIZED MEDICINE LA English DT Review DE biomarkers; diagnostics; enzyme-linked immunosorbent assay; individualized medicine; mass spectrometry; proteins; proteomics ID TANDEM MASS-SPECTROMETRY; CELL LUNG-CANCER; LINKED-IMMUNOSORBENT-ASSAY; ANTIBODY-BASED PROTEOMICS; LIQUID-CHROMATOGRAPHY; QUANTITATIVE-ANALYSIS; BIOMARKER DISCOVERY; NEXT-GENERATION; PLASMA PROTEOME; FUTURE FIELDS AB The sequencing of the human genome has brought great promise and potential for the future of medicine, as well as providing a strong momentum for the burgeoning field of individualized medicine. Tests based on genetic information can be used to allow physicians to target therapies for those patients most likely to benefit from specific therapies and identify potential risk before the onset of disease. While advances in genomics-based molecular diagnostics are progressing, producing some useful US FDA-approved/-cleared diagnostic tests, protein-based molecular diagnostics have not met its promised potential. This article will provide an overview of protein-based analysis technologies, identify their strengths and limitations, discuss barriers to protein-based biomarker development and identify issues which must be addressed in order to successfully transfer the field of proteomics from the laboratory to the clinic. C1 [Rahbar, Amir; Rivers, Robert; Boja, Emily; Kinsinger, Christopher; Mesri, Mehdi; Hiltke, Tara; Rodriguez, Henry] NCI, Off Canc Clin Proteom Res, Ctr Strateg Sci Initiat, NIH, Bethesda, MD 20892 USA. RP Rodriguez, H (reprint author), NCI, Off Canc Clin Proteom Res, Ctr Strateg Sci Initiat, NIH, 31 Ctr Dr, Bethesda, MD 20892 USA. EM rodriguezh@mail.nih.gov RI Mendez, Pedro /J-8955-2016 OI Mendez, Pedro /0000-0001-6713-7907 NR 91 TC 2 Z9 3 U1 0 U2 1 PU FUTURE MEDICINE LTD PI LONDON PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3 1QB, ENGLAND SN 1741-0541 J9 PERS MED JI Pers. Med. PD JAN PY 2011 VL 8 IS 1 BP 45 EP 57 DI 10.2217/PME.10.76 PG 13 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 716HY UT WOS:000286960900011 ER PT J AU Amaruchkul, K Cooper, WL Gupta, D AF Amaruchkul, Kannapha Cooper, William L. Gupta, Diwakar TI A Note on Air-Cargo Capacity Contracts SO PRODUCTION AND OPERATIONS MANAGEMENT LA English DT Article DE capacity contracts; asymmetric information; informational rents ID SUPPLY CONTRACTS; INFORMATION; ALLOCATION; MECHANISMS; DEMANDS AB Carriers (airlines) use medium-term contracts to allot bulk cargo capacity to forwarders who deliver consolidated loads for each flight in the contractual period (season). Carriers also sell capacity to direct-ship customers on each flight. We study capacity contracts between a carrier and a forwarder when certain parameters such as the forwarder's demand, operating cost to the carrier, margin, and reservation profit are its private information. We propose contracts in which the forwarder pays a lump sum in exchange for a guaranteed capacity allotment and receives a refund for each unit of unused capacity according to a pre-announced refund rate. We obtain an upper bound on the informational rent paid by the carrier for a menu of arbitrary allotments and identify conditions under which it can eliminate the informational rent and induce the forwarder to choose the overall optimal capacity allotment (i.e., one that maximizes the combined profits of the carrier and the forwarder). C1 [Amaruchkul, Kannapha] NIDA, Sch Appl Stat, Bangkok 10240, Thailand. [Cooper, William L.; Gupta, Diwakar] Univ Minnesota, Program Ind & Syst Engn, Minneapolis, MN 55455 USA. RP Amaruchkul, K (reprint author), NIDA, Sch Appl Stat, Bangkok 10240, Thailand. EM kamaruchkul@gmail.com; billcoop@me.umn.edu; guptad@me.umn.edu FU National Science Foundation [DMI-0450359] FX This material is based on work supported, in part, by the National Science Foundation under Grant No. DMI-0450359. The authors are grateful to the referees and the senior editor for their constructive comments on an earlier version of this paper. NR 27 TC 8 Z9 9 U1 0 U2 10 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1059-1478 J9 PROD OPER MANAG JI Prod. Oper. Manag. PD JAN-FEB PY 2011 VL 20 IS 1 BP 152 EP 162 DI 10.1111/j.1937-5956.2010.01158.x PG 11 WC Engineering, Manufacturing; Operations Research & Management Science SC Engineering; Operations Research & Management Science GA 701PJ UT WOS:000285832900012 ER PT J AU Kirkpatrick, B Fleming, LE Bean, JA Nierenberg, K Backer, LC Cheng, YS Pierce, R Reich, A Naar, J Wanner, A Abraham, WM Zhou, Y Hollenbeck, J Baden, DG AF Kirkpatrick, Barbara Fleming, Lora E. Bean, Judy A. Nierenberg, Kate Backer, Lorraine C. Cheng, Yung Sung Pierce, Richard Reich, Andrew Naar, Jerome Wanner, Adam Abraham, William M. Zhou, Yue Hollenbeck, Julie Baden, Daniel G. TI Aerosolized red tide toxins (brevetoxins) and asthma: Continued health effects after 1 h beach exposure SO HARMFUL ALGAE LA English DT Article DE Coastal; Harmful algal blooms (HABs); Inhalation toxicity; Karenia brevis ID MARINE AEROSOL; FLORIDA; BREVIS AB Blooms of the toxic dinoflagellate. Karenia brevis, produce potent neurotoxins in marine aerosols. Recent studies have demonstrated acute changes in both symptoms and pulmonary function in asthmatics after only 1 h of beach exposure to these aerosols. This study investigated if there were latent and/or sustained effects in asthmatics in the days following the initial beach exposure during periods with and without an active Florida red tide. Symptom data and spirometry data were collected before and after 1 h of beach exposure. Subjects kept daily symptom diaries and measured their peak flow each morning for 5 days following beach exposure. During non-exposure periods, there were no significant changes in symptoms or pulmonary function either acutely or over 5 days of follow-up. After the beach exposure during an active Florida red tide, subjects had elevated mean symptoms which did not return to the pre-exposure baseline for at least 4 days. The peak flow measurements decreased after the initial beach exposure, decreased further within 24 h, and continued to be suppressed even after 5 days. Asthmatics may continue to have increased symptoms and delayed respiratory function suppression for several days after 1 h of exposure to the Florida red tide toxin aerosols. (C) 2010 Elsevier B.V. All rights reserved. C1 [Kirkpatrick, Barbara; Nierenberg, Kate; Pierce, Richard] Mote Marine Lab, Sarasota, FL 34236 USA. [Fleming, Lora E.; Hollenbeck, Julie] Univ Miami, Rosenstiel Sch Marine & Atmospher Sci, NSF, Miami, FL 33149 USA. [Fleming, Lora E.; Hollenbeck, Julie] Univ Miami, Rosenstiel Sch Marine & Atmospher Sci, NIEHS Oceans & Human Hlth Ctr, Miami, FL 33149 USA. [Fleming, Lora E.; Wanner, Adam] Univ Miami, Sch Med, Miami, FL 33136 USA. [Bean, Judy A.] Childrens Hosp Med Ctr, Cincinnati, OH USA. [Bean, Judy A.] Univ Cincinnati, Cincinnati, OH USA. [Backer, Lorraine C.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. [Cheng, Yung Sung] Lovelace Resp Res Inst, Albuquerque, NM 87108 USA. [Reich, Andrew] Florida Dept Hlth, Tallahassee, FL 32399 USA. [Naar, Jerome; Baden, Daniel G.] Univ N Carolina, Ctr Marine Sci, Wilmington, NC 28409 USA. [Abraham, William M.] Mt Sinai Med Ctr, Miami Beach, FL 33140 USA. RP Fleming, LE (reprint author), Publ Hlth Univ Miami, Sch Med, Dept Epidemiol, Clin Res Bldg CRB,10th Floor,1120 NW 14th S, Miami, FL 33136 USA. EM lfleming@med.miami.edu FU National Institute of Environmental Health Sciences (NIEHS) [P01 ES 10594, 1 P50 ES12736]; Centers for Disease Control and Prevention (CDC); Florida Department of Health; Florida Dept of Environmental Protection (FL DEP) Florida Red Tide Control and Mitigation; National Science Foundation (NSF); National Institute of Environmental Health Sciences (NIEHS) Oceans and Human Health Center at the University of Miami Rosenstiel School [NSF] [NSF OCE0432368, NSF OCE0911373] FX This research was supported by the National Institute of Environmental Health Sciences (NIEHS) Aerosolized Florida Red Tide PO1 [P01 ES 10594] with a Minority Supplement, as well as by the Centers for Disease Control and Prevention (CDC), and the Florida Department of Health. Additional support was received from the Florida Dept of Environmental Protection (FL DEP) Florida Red Tide Control and Mitigation; the National Science Foundation (NSF) and the National Institute of Environmental Health Sciences (NIEHS) Oceans and Human Health Center at the University of Miami Rosenstiel School [NSF OCE0432368 and NSF OCE0911373];[NIEHS 1 P50 ES12736].[SS] NR 24 TC 11 Z9 11 U1 0 U2 16 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1568-9883 J9 HARMFUL ALGAE JI Harmful Algae PD JAN PY 2011 VL 10 IS 2 BP 138 EP 143 DI 10.1016/j.hal.2010.08.005 PG 6 WC Marine & Freshwater Biology SC Marine & Freshwater Biology GA 714XP UT WOS:000286845300003 PM 21499552 ER PT J AU Chang, R Lozier, JN Horne, MK AF Chang, R. Lozier, J. N. Horne, M. K., III TI Thrombolytic Therapy with Tissue Plasminogen Activator: Why Prolonged Continuous Infusion is not the Best Approach SO JOURNAL OF VASCULAR SURGERY LA English DT Meeting Abstract CT 5th Annual Academic Surgical Congress CY FEB 03-05, 2010 CL San Antonio, TX SP Assoc Acad Surg, Soc Univ Surg C1 [Chang, R.; Lozier, J. N.; Horne, M. K., III] NIH, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD JAN PY 2011 VL 53 IS 1 BP 260 EP 260 DI 10.1016/j.jvs.2010.11.027 PG 1 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 704WB UT WOS:000286085200067 ER PT J AU Mukai, I Bahadur, K Kesavabhotla, K Ungerleider, LG AF Mukai, Ikuko Bahadur, Kandy Kesavabhotla, Kartik Ungerleider, Leslie G. TI Exogenous and endogenous attention during perceptual learning differentially affect post-training target thresholds SO JOURNAL OF VISION LA English DT Article DE perceptual learning; exogenous attention; endogenous attention; contrast threshold; Gabor patch ID PRIMARY VISUAL-CORTEX; CONTRAST RESPONSE FUNCTIONS; SELECTIVE ATTENTION; STAIRCASE-METHOD; TIME-COURSE; DISCRIMINATION; ORIENTATION; PSYCHOPHYSICS; SPECIFICITY; MECHANISMS AB There is conflicting evidence in the literature regarding the role played by attention in perceptual learning. To further examine this issue, we independently manipulated exogenous and endogenous attention and measured the rate of perceptual learning of oriented Gabor patches presented in different quadrants of the visual field. In this way, we could track learning at attended, divided-attended, and unattended locations. We also measured contrast thresholds of the Gabor patches before and after training. Our results showed that, for both exogenous and endogenous attention, accuracy in performing the orientation discrimination improved to a greater extent at attended than at unattended locations. Importantly, however, only exogenous attention resulted in improved contrast thresholds. These findings suggest that both exogenous and endogenous attention facilitate perceptual learning, but that these two types of attention may be mediated by different neural mechanisms. C1 [Mukai, Ikuko; Bahadur, Kandy; Kesavabhotla, Kartik; Ungerleider, Leslie G.] NIMH, Lab Brain & Cognit, NIH, Bethesda, MD 20892 USA. RP Mukai, I (reprint author), NIMH, Lab Brain & Cognit, NIH, Bldg 10,Room 4C104,10 Ctr Dr, Bethesda, MD 20892 USA. EM mukaii@mail.nih.gov FU National Institutes of Health-National Institute of Mental Health FX This work was supported by the Intramural Research Program of the National Institutes of Health-National Institute of Mental Health. We Thank Dr. John Ingeholm for providing technical support for the eye tracker, Dr. Gang Chen for giving us valuable comments on the statistical analyses, and Olivia Wu for assistance with data collection. NR 61 TC 3 Z9 3 U1 0 U2 8 PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC PI ROCKVILLE PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA SN 1534-7362 J9 J VISION JI J. Vision PY 2011 VL 11 IS 1 AR 25 DI 10.1167/11.1.25 PG 15 WC Ophthalmology SC Ophthalmology GA 726OI UT WOS:000287732900025 ER PT J AU Helman, LJ AF Helman, L. J. TI Targeting the IGF1 Pathway in Pediatric Sarcomas SO KLINISCHE PADIATRIE LA English DT Meeting Abstract C1 [Helman, L. J.] NCI, Ctr Canc Res, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0300-8630 J9 KLIN PADIATR JI Klinische Padiatr. PD JAN PY 2011 VL 223 IS 1 MA 3 BP 46 EP 46 DI 10.1055/s-0030-1270296 PG 1 WC Pediatrics SC Pediatrics GA 725ED UT WOS:000287627100015 ER PT J AU Chen, HL Gao, XA Ascherio, A AF Chen, Honglei Gao, Xiang Ascherio, Alberto TI Prospective Research on Parkinson Nonmotor Symptoms SO ARCHIVES OF NEUROLOGY LA English DT Letter ID DISEASE; RISK C1 [Chen, Honglei] NIEHS, Epidemiol Branch, Res Triangle Pk, NC 27709 USA. [Gao, Xiang; Ascherio, Alberto] Harvard Univ, Sch Publ Hlth, Cambridge, MA 02138 USA. RP Chen, HL (reprint author), NIEHS, Epidemiol Branch, Mail Drop A3-05,111 TW Alexander Dr,Rall Bldg 101, Res Triangle Pk, NC 27709 USA. EM chenh2@niehs.nih.gov OI Chen, Honglei/0000-0003-3446-7779 NR 6 TC 2 Z9 2 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0003-9942 J9 ARCH NEUROL-CHICAGO JI Arch. Neurol. PD JAN PY 2011 VL 68 IS 1 BP 137 EP 137 DI 10.1001/archneurol.2010.332 PG 1 WC Clinical Neurology SC Neurosciences & Neurology GA 704MO UT WOS:000286057300026 PM 21220690 ER PT J AU Vexler, A Liu, SL Schisterman, EF AF Vexler, Albert Liu, Shuling Schisterman, Enrique F. TI Nonparametric-likelihood inference based on cost-effectively-sampled-data SO JOURNAL OF APPLIED STATISTICS LA English DT Article DE confidence interval; cost-efficient design; empirical likelihood; nonparametric method; pooling design; power; random sampling; Student's t-test; type-I error ID ROC CURVE ANALYSIS; EMPIRICAL LIKELIHOOD; POOLED ASSESSMENTS; DIAGNOSTIC-ACCURACY; BIOMARKERS; BIOSPECIMENS; SUBJECT; LIMIT AB Costs associated with the evaluation of biomarkers can restrict the number of relevant biological samples to be measured. This common problem has been dealt with extensively in the epidemiologic and biostatistical literature that proposes to apply different cost-efficient procedures, including pooling and random sampling strategies. The pooling design has been widely addressed as a very efficient sampling method under certain parametric assumptions regarding data distribution. When cost is not a main factor in the evaluation of biomarkers but measurement is subject to a limit of detection, a common instrument limitation on the measurement process, the pooling design can partially overcome this instrumental limitation. In certain situations, the pooling design can provide data that is less informative than a simple random sample; however this is not always the case. Pooled-data-based nonparametric inferences have not been well addressed in the literature. In this article, a distribution-free method based on the empirical likelihood technique is proposed to substitute the traditional parametric-likelihood approach, providing the true coverage, confidence interval estimation and powerful tests based on data obtained after the cost-efficient designs. We also consider several nonparametric tests to compare with the proposed procedure. We examine the proposed methodology via a broad Monte Carlo study and a real data example. C1 [Vexler, Albert; Liu, Shuling] SUNY Buffalo, Dept Biostat, Buffalo, NY 14260 USA. [Schisterman, Enrique F.] NICHHD, Div Epidemiol Stat & Prevent Res, NIH, DHHS, Rockville, MD USA. RP Vexler, A (reprint author), SUNY Buffalo, Dept Biostat, Buffalo, NY 14260 USA. EM avexler@buffalo.edu OI Schisterman, Enrique/0000-0003-3757-641X FU Eunice Kennedy Shriver National Institute of Child Health and Human Development FX This work was supported in part with funding from the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development. The authors thank the reviewers for their insightful comments that have greatly helped us improve the article. NR 19 TC 5 Z9 5 U1 1 U2 1 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0266-4763 J9 J APPL STAT JI J. Appl. Stat. PY 2011 VL 38 IS 4 BP 769 EP 783 DI 10.1080/02664761003692290 PG 15 WC Statistics & Probability SC Mathematics GA 717CP UT WOS:000287020600010 ER PT J AU Taylor, J Mariotti, J Fowler, DH AF Taylor, J. Mariotti, J. Fowler, D. H. TI THE PENTOSTATIN PLUS CYCLOPHOSPHAMIDE (PC) NON-MYELOABLATIVE REGIMEN INDUCES DURABLE HOST T CELL FUNCTIONAL DEFICITS AND PREVENTS MARROW ALLOGRAFT REJECTION SO JOURNAL OF INVESTIGATIVE MEDICINE LA English DT Meeting Abstract C1 [Taylor, J.] Univ New Mexico, Sch Med, Albuquerque, NM 87131 USA. [Taylor, J.; Mariotti, J.; Fowler, D. H.] NCI, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1081-5589 J9 J INVEST MED JI J. Invest. Med. PD JAN PY 2011 VL 59 IS 1 MA 100 BP 116 EP 116 PG 1 WC Medicine, General & Internal; Medicine, Research & Experimental SC General & Internal Medicine; Research & Experimental Medicine GA 697TZ UT WOS:000285542500115 ER PT J AU Dolan, JG Wan, X Yeung, C Helman, LJ AF Dolan, J. G. Wan, X. Yeung, C. Helman, L. J. TI TARGETING FOXM1 TRANSCRIPTION FACTOR IN RHABDOMYOSARCOMA SO JOURNAL OF INVESTIGATIVE MEDICINE LA English DT Meeting Abstract C1 [Dolan, J. G.] Univ Washington, Sch Med, Seattle, WA USA. [Wan, X.; Yeung, C.; Helman, L. J.] NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1081-5589 J9 J INVEST MED JI J. Invest. Med. PD JAN PY 2011 VL 59 IS 1 MA 342 BP 183 EP 183 PG 1 WC Medicine, General & Internal; Medicine, Research & Experimental SC General & Internal Medicine; Research & Experimental Medicine GA 697TZ UT WOS:000285542500357 ER PT J AU Shinomiya, K Kobayashi, H Inokuchi, N Nakagomi, K Ito, Y AF Shinomiya, Kazufusa Kobayashi, Hiroko Inokuchi, Norio Nakagomi, Kazuya Ito, Yoichiro TI PARTITION EFFICIENCY OF HIGH-PITCH LOCULAR MULTILAYER COIL FOR COUNTERCURRENT CHROMATOGRAPHIC SEPARATION OF PROTEINS USING SMALL-SCALE CROSS-AXIS COIL PLANET CENTRIFUGE AND APPLICATION TO PURIFICATION OF VARIOUS COLLAGENASES WITH AQUEOUS-AQUEOUS POLYMER PHASE SYSTEMS SO JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES LA English DT Article DE collagenases; countercurrent chromatography; cross-axis coil planet centrifuge; high-pitch multilayer coil; locular tubing; polymer phase system; proteins; purification ID ROTARY SEALS; APPARATUS; ASSEMBLIES; COLUMNS; DESIGN AB Partition efficiency of the high-pitch locular multilayer coil was evaluated in countercurrent chromatographic (CCC) separation of proteins with an aqueous-aqueous polymer phase system using the small-scale cross-axis coil planet centrifuge (X-axis CPC) fabricated in our laboratory. The separation column was specially made by high-pitch (ca 5cm) winding of 1.0mm I.D., 2.0mm O.D. locular tubing compressed at 2cm intervals with a total capacity of 29.5mL. The protein separation was performed using a set of stable proteins including cytochrome C, myoglobin, and lysozyme with the 12.5% (w/w) polyethylene glycol (PEG) 1000 and 12.5% (w/w) dibasic potassium phosphate system (pH 9.2) under 1000rpm of column revolution. This high-pitch locular tubing yielded substantially higher stationary phase retention than the normal locular tubing for both lower and upper mobile phases. In order to demonstrate the capability of the high-pitch locular tubing, the purification of collagenase from the crude commercial sample was carried out using an aqueous-aqueous polymer phase system. Using the 16.0% (w/w) PEG 1000-6.3% (w/w) dibasic potassium phosphate-6.3% (w/w) monobasic potassium phosphate system (pH 6.6), collagenase I, II, IV, V, and X derived from Clostridium histolyticum were separated from other proteins and colored small molecular weight compounds present in the crude commercial sample. Collagenase from C. histolyticum well retained its enzymatic activity in the purified fractions. The overall results demonstrated that the high-pitch locular multilayer coil is effectively used for the CCC purification of bioactive compounds without loss of their enzymatic activities. C1 [Shinomiya, Kazufusa; Kobayashi, Hiroko; Inokuchi, Norio] Nihon Univ, Sch Pharm, Funabashi, Chiba 2748555, Japan. [Nakagomi, Kazuya] Teikyo Univ, Fac Pharmaceut Sci, Kanagawa, Japan. [Ito, Yoichiro] NHLBI, Bioseparat Technol Lab, Biochem & Biophys Ctr, NIH, Bethesda, MD 20892 USA. RP Shinomiya, K (reprint author), Nihon Univ, Sch Pharm, 7-7-1 Narashinodai, Funabashi, Chiba 2748555, Japan. EM shinomiya.kazufusa@nihon-u.ac.jp FU Ministry of Education, Culture, Sports, Science, and Technology of Japan FX This work was supported by a grant from the Ministry of Education, Culture, Sports, Science, and Technology of Japan. The authors would like to thank Mr. Kazunori Yoshida and Mr. Kazuhiro Yanagidaira (College of Science and Technology, Nihon University, Chiba, Japan) for their technical assistance. The authors are also indebted to Mr. Susumu Kasahara (Takacho Co., Tokyo, Japan) for his helpful advice. NR 17 TC 3 Z9 3 U1 1 U2 9 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1082-6076 J9 J LIQ CHROMATOGR R T JI J. Liq. Chromatogr. Relat. Technol. PY 2011 VL 34 IS 3 BP 182 EP 194 AR PII 933012174 DI 10.1080/10826076.2011.546151 PG 13 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 715PA UT WOS:000286895200003 PM 21869859 ER PT J AU Lee, SM Romero, R Lee, KA Yang, HJ Oh, KJ Park, CW Yoon, BH AF Lee, Seung Mi Romero, Roberto Lee, Kyung A. Yang, Hye Jin Oh, Kyung Joon Park, Chan-Wook Yoon, Bo Hyun TI The frequency and risk factors of funisitis and histologic chorioamnionitis in pregnant women at term who delivered after the spontaneous onset of labor SO JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE LA English DT Article DE infection; inflammation; nulliparity; duration of labor; prolonged labour; rupture of membranes; pregnancy ID AMNIOTIC-FLUID; INTRAAMNIOTIC INFLAMMATION; CEREBRAL-PALSY; UMBILICAL-CORD; MICROBIAL INVASION; PRETERM LABOR; INTERLEUKIN-6; INFECTION; PLACENTA; PARTURITION AB Objective. To examine the frequency and risk factors of funisitis and histologic chorioamnionitis in the placentas of term pregnant women who delivered after the spontaneous onset of labor. Methods. The frequency of funisitis and histologic chorioamnionitis was examined in consecutive pregnant women at term with singleton pregnancies who delivered after the spontaneous onset of labor. Nonparametric statistics were used for data analysis. Results. (1) The frequency of funisitis and histologic chorioamnionitis was 6.7% (88/1316) and 23.6% (310/1316), respectively; (2) Patients with funisitis had significantly higher rates of nulliparity, regional analgesia, operative vaginal delivery, longer duration of labor and rupture of membranes (ROM), and higher gestational age and birthweight than those without funisitis (p < 0.05 for each); (3) Patients with histologic chorioamnionitis had significantly higher rates of nulliparity, oxytocin augmentation, regional analgesia, cesarean section or operative vaginal delivery, longer duration of labor and ROM, and higher gestational age and birthweight than those without histologic chorioamnionitis (p < 0.05 for each); (4) Multiple logistic regression analysis indicated that the longer the duration of labor, the higher the risk of funisitis, and that nulliparity and the duration of labor significantly increased the odds of histologic chorioamnionitis (p < 0.05 for each). Conclusion. The longer the duration of labor, the higher the risk of funisitis and histologic chorioamnionitis in pregnant women at term who delivered after the spontaneous onset of labor. C1 [Lee, Seung Mi; Lee, Kyung A.; Yang, Hye Jin; Oh, Kyung Joon; Park, Chan-Wook; Yoon, Bo Hyun] Seoul Natl Univ, Dept Obstet & Gynecol, Coll Med, Seoul 110744, South Korea. [Romero, Roberto] NICHD, Perinatol Res Branch, NIH, DHHS, Detroit, MI USA. RP Yoon, BH (reprint author), Seoul Natl Univ, Dept Obstet & Gynecol, Coll Med, Seoul 110744, South Korea. EM yoonbh@snu.ac.kr RI Yoon, Bo Hyun/H-6344-2011; Park, Chan-Wook/J-5498-2012 FU Korea government (MEST) [2009-0080429]; Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS FX This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (No. 2009-0080429) and in part by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS. NR 37 TC 16 Z9 16 U1 0 U2 4 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1476-7058 J9 J MATERN-FETAL NEO M JI J. Matern.-Fetal Neonatal Med. PD JAN PY 2011 VL 24 IS 1 BP 37 EP 42 DI 10.3109/14767058.2010.482622 PG 6 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 717XJ UT WOS:000287080700004 ER PT J AU Flessner, MF AF Flessner, M. F. TI No Change in Small Molecule Transport with Prolonged Embedding of Peritoneal Dialysis Catheters Response SO PERITONEAL DIALYSIS INTERNATIONAL LA English DT Letter C1 NIDDK, Div Kidney Urol & Hematol Dis, Bethesda, MD 20892 USA. RP Flessner, MF (reprint author), NIDDK, Div Kidney Urol & Hematol Dis, Bethesda, MD 20892 USA. EM flessnermf@niddk.nih.gov NR 1 TC 0 Z9 0 U1 0 U2 0 PU MULTIMED INC PI TORONTO PA 66 MARTIN ST, TORONTO, ON L9T 2R2, CANADA SN 0896-8608 J9 PERITON DIALYSIS INT JI Perit. Dial. Int. PD JAN-FEB PY 2011 VL 31 IS 1 DI 10.3747/pdi.2010.00179 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA 713HN UT WOS:000286726800023 ER PT J AU Starr, JM Scollon, EJ Hughes, MF Graham, SE Ross, DG Crofton, KM Wolansky, M DeVito, MJ Tornero-Velez, R AF Starr, James M. Scollon, Edward J. Hughes, Michael F. Graham, Stephen E. Ross, David G. Crofton, Kevin M. Wolansky, Marcelo DeVito, Michael J. Tornero-Velez, Rogelio TI Using a Chemical Mixture of Pyrethroid Pesticides to Determine Rodent Tissue Clearance Rates SO EPIDEMIOLOGY LA English DT Meeting Abstract CT Joint Conference of International-Society-of-Exposure-Science/International-Society-for-Envi ronmental-Epidemiology CY AUG 28-SEP 01, 2010 CL Seoul, SOUTH KOREA SP Int Soc Exposure Sci, Int Soc Environm Epidemiol C1 [Starr, James M.; Tornero-Velez, Rogelio] US EPA, Human Exposure & Atmospher Sci Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC USA. [Scollon, Edward J.; Hughes, Michael F.; Ross, David G.; Crofton, Kevin M.; Wolansky, Marcelo; DeVito, Michael J.] US EPA, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC USA. [Scollon, Edward J.] US EPA, Div Hlth Effects, Off Pesticide Programs, Arlington, VA USA. [Graham, Stephen E.] US EPA, Hlth & Environm Impacts Div, Off Air Qual Planning & Stand, Res Triangle Pk, NC USA. [Wolansky, Marcelo] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Biol, Lab Toxicol Mezclas Quim LATOMEQ, Buenos Aires, DF, Argentina. [DeVito, Michael J.] Natl Inst Environm Hlth Sci, Toxicol Branch, Natl Toxicol Program, Res Triangle Pk, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1044-3983 EI 1531-5487 J9 EPIDEMIOLOGY JI Epidemiology PD JAN PY 2011 VL 22 IS 1 SU S BP S249 EP S250 DI 10.1097/01.ede.0000392458.01615.b0 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 695VN UT WOS:000285400800766 ER PT J AU Wang, XH Liang, Y Peng, CL Xie, HC Pan, M Zhang, TY Ito, Y AF Wang, Xiaohong Liang, Yong Peng, Cuilin Xie, Huichun Pan, Man Zhang, Tianyou Ito, Yoichiro TI PREPARATIVE ISOLATION AND PURIFICATION OF CHEMICAL CONSTITUENTS OF BELAMCANDA BY MPLC, HSCCC, AND PREP-HPLC SO JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES LA English DT Article DE Belamcanda; high-speed countercurrent chromatography; isoflavonoids; medium-pressure liquid chromatography; preparative high-pressure liquid chromatography ID COUNTER-CURRENT CHROMATOGRAPHY; MASS-SPECTROMETRY; SEPARATION; CHINENSIS AB Combined with medium-pressure liquid chromatography (MPLC) and preparative high-pressure liquid chromatography (Prep-HPLC), high-speed countercurrent chromatography (HSCCC) was successfully applied for separation and purification of isoflavonoids from the extract of belamcanda. HSCCC separation was performed on a two-phase solvent system composed of methyl tert-butyl ether-ethyl acetate-n-butyl alcohol-acetonitrile-0.1% aqueous trifluoroacetic acid at a volume radio of 1:2:1:1:5. Semi-purified peak fractions from HSCCC separation were further purified by Prep-HPLC. Nine well-separated fractions were analyzed by HPLC-UV absorption spectrometry to determine their purities and characterized with ESI-MSn. Except for peaks I and VII (unknown), seven compounds were identified as apocynin (peak II), mangiferin (peak III), 7-O-methylmangiferin (peak IV), hispidulin (peak V), 3'-hydroxyltectoridin (peak VI), iristectorin B (peak VIII), and isoiridin (peak IX). C1 [Ito, Yoichiro] NHLBI, Bioseparat Technol Lab, Biochem & Biophys Ctr, NIH, Bethesda, MD 20892 USA. [Wang, Xiaohong; Liang, Yong; Peng, Cuilin; Xie, Huichun; Pan, Man] S China Normal Univ, Inst Analyt Chem, Sch Chem & Environm, Guangzhou, Guangdong, Peoples R China. [Zhang, Tianyou] Beijing Inst New Technol Applicat, Beijing, Peoples R China. RP Ito, Y (reprint author), NHLBI, Bioseparat Technol Lab, Biochem & Biophys Ctr, NIH, Bldg 10,Room 8N230,10 Ctr Dr MSC 1762, Bethesda, MD 20892 USA. EM itoy2@mail.nih.gov FU Intramural NIH HHS [Z99 HL999999] NR 12 TC 6 Z9 6 U1 0 U2 8 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1082-6076 J9 J LIQ CHROMATOGR R T JI J. Liq. Chromatogr. Relat. Technol. PY 2011 VL 34 IS 4 BP 241 EP 257 AR PII 932996606 DI 10.1080/10826076.2011.547058 PG 17 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 715OY UT WOS:000286895000001 PM 21552369 ER PT J AU Loeb, S Carter, HB Schaeffer, EM Kettermann, A Ferrucci, L Metter, EJ AF Loeb, Stacy Carter, H. Ballentine Schaeffer, Edward M. Kettermann, Anna Ferrucci, Luigi Metter, E. Jeffrey TI Distribution of PSA Velocity by Total PSA Levels: Data From the Baltimore Longitudinal Study of Aging REPLY SO UROLOGY LA English DT Editorial Material ID ANTIGEN VELOCITY; PROSTATE-CANCER C1 [Loeb, Stacy; Carter, H. Ballentine; Schaeffer, Edward M.; Kettermann, Anna] Johns Hopkins Med Inst, James Buchanan Brady Urol Inst, Baltimore, MD 21205 USA. [Ferrucci, Luigi; Metter, E. Jeffrey] NIA, NIH, Baltimore, MD 21224 USA. RP Loeb, S (reprint author), Johns Hopkins Med Inst, James Buchanan Brady Urol Inst, Baltimore, MD 21205 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-4295 J9 UROLOGY JI Urology PD JAN PY 2011 VL 77 IS 1 BP 148 EP 148 DI 10.1016/j.urology.2010.06.032 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA 700XM UT WOS:000285778800046 ER PT J AU Brzezinski, K Tomkiel, AM Lotowski, Z Morzycki, J Dauter, Z AF Brzezinski, Krzysztof Tomkiel, Aneta M. Lotowski, Zenon Morzycki, Jacek Dauter, Zbigniew TI Bis[3 alpha,7 alpha,12 alpha-tris(4-nitrobenzoyloxy)-5 beta-cholan-24-yl] disulfide-ethyl acetate-n-hexane (4/4/1) SO ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE LA English DT Article ID BILE-ACIDS; SUPRAMOLECULAR CHEMISTRY; DERIVATIVES; STEROIDS AB The crystal structure of the title compound, C90H100N6O24S2 center dot C4H8O2 center dot 0.25C(6)H(14), solved and refined against synchrotron diffraction data, contains two formula units in the asymmetric unit with the all-trans n-hexane molecule having half-occupancy and one of the ethyl acetate molecules disordered over two positions. The two symmetry-independent disulfide molecules are assembled by approximate face-to-face and face-to-edge interactions between their 4-nitrobenzoyloxy groups into an intertwined dimer having a double-helix-type structure. The centrally placed disulfide bridges in the two symmetry-independent molecules exhibit different helicity as shown by the C-S-S-C torsion angles of 71.0 (1) and -92.5 (1)degrees. C1 [Brzezinski, Krzysztof; Dauter, Zbigniew] Argonne Natl Lab, Natl Canc Inst, MCL, Synchrotron Radiat Res Sect, Argonne, IL 60439 USA. [Tomkiel, Aneta M.; Lotowski, Zenon; Morzycki, Jacek] Univ Bialystok, Inst Chem, PL-15443 Bialystok, Poland. RP Brzezinski, K (reprint author), Argonne Natl Lab, Natl Canc Inst, MCL, Synchrotron Radiat Res Sect, 9700 S Cass Ave, Argonne, IL 60439 USA. EM kbrzezinski@anl.gov FU University of Bialystok [BST-124]; NIH, National Cancer Institute, Center for Cancer Research; US Department of Energy [W-31-109-Eng-38] FX Financial support from the University of Bialystok within the project BST-124 is gratefully acknowledged. This work was supported in part by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research. X-ray data were collected at the NECAT 24ID-C beamline of the Advanced Photon Source, Argonne National Laboratory. Use of the APS was supported by the US Department of Energy under contract No. W-31-109-Eng-38. NR 20 TC 0 Z9 0 U1 2 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1600-5368 J9 ACTA CRYSTALLOGR E JI Acta Crystallogr. Sect. E.-Struct Rep. Online PD JAN PY 2011 VL 67 BP O74 EP U1990 DI 10.1107/S1600536810050385 PN 1 PG 48 WC Crystallography SC Crystallography GA 698XQ UT WOS:000285628900170 ER PT J AU Branch, D Zhang, J Troendle, J Beaver, J AF Branch, David Zhang, Jun Troendle, James Beaver, Julie TI Current labor outcomes compared to those when I Want to Hold Your Hand was # 1 SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 01-06, 2010 CL Chicago, IL SP Soc Maternal Fetal Med C1 [Branch, David] Intermt Healthcare, Salt Lake City, UT USA. [Branch, David] Univ Utah, Hlth Sci Ctr, Salt Lake City, UT USA. [Zhang, Jun] NICHD, Bethesda, MD USA. [Troendle, James; Beaver, Julie] NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 1 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2011 VL 204 SU 1 MA 298 BP S123 EP S123 DI 10.1016/j.ajog.2010.10.316 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 702WV UT WOS:000285927500297 ER PT J AU Burkman, R Gregory, K Hoffman, M Bailit, JL Van Veldhusien, P Liu, L Branch, W Haberman, S Landy, H Troendle, J Zhang, J Reddy, U Hatjis, C Wilkins, I Kominiarek, M Hibbard, J Gonzalez, V Ramirez, M AF Burkman, Ronald Gregory, Kimberly Hoffman, Matthew Bailit, Jennifer L. Van Veldhusien, Paul Liu, Li Branch, Ware Haberman, Shoshana Landy, Helain Troendle, James Zhang, Jun Reddy, Uma Hatjis, Christos Wilkins, Isabelle Kominiarek, Michelle Hibbard, Judith Gonzalez, Victor Ramirez, Mildred TI Predictors of shoulder dystocia with and without neonatal injury using multivariable modeling SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 01-06, 2010 CL Chicago, IL SP Soc Maternal Fetal Med C1 [Burkman, Ronald] Baystate Med Ctr, Springfield, MA USA. [Gregory, Kimberly] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA. [Hoffman, Matthew] Christiana Care Hlth Syst, Newark, DE USA. [Bailit, Jennifer L.] Case Western Reserve Univ, Dept OB GYN, Div Maternal Fetal Med, MetroHlth Med Ctr, Cleveland, OH 44106 USA. [Van Veldhusien, Paul; Liu, Li] EMMES Corp, Rockville, MD USA. [Branch, Ware] Univ Utah, Salt Lake City, UT USA. [Branch, Ware] Intermt Healthcare, Salt Lake City, UT USA. [Haberman, Shoshana] Maimonides Hosp, Brooklyn, NY 11219 USA. [Landy, Helain] MedStar Hlth Georgetown Univ Hosp, Washington, DC USA. [Troendle, James; Zhang, Jun] NICHHD, Bethesda, MD 20892 USA. [Reddy, Uma] Pregnancy & Perinatol Branch, Bethesda, MD USA. [Hatjis, Christos] Summa Hlth Syst, Akron, OH USA. [Wilkins, Isabelle; Kominiarek, Michelle; Hibbard, Judith] Univ Illinois, Chicago, IL USA. [Gonzalez, Victor] Univ Miami, Miami, FL USA. [Ramirez, Mildred] Univ Texas Houston, Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2011 VL 204 SU 1 MA 314 BP S129 EP S130 PG 3 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 702WV UT WOS:000285927500313 ER PT J AU Carreno, C AF Carreno, Carlos TI Excessive early gestational weight gain and risks of gestational diabetes and large for gestational age infants in nulliparous women SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 01-06, 2010 CL Chicago, IL SP Soc Maternal Fetal Med C1 [Carreno, Carlos] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Maternal Fetal Med Units Network, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2011 VL 204 SU 1 MA 803 BP S314 EP S314 DI 10.1016/j.ajog.2010.10.825 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 702WV UT WOS:000285927500800 ER PT J AU Clark, EAS AF Clark, Erin A. S. TI Interleukin 6 receptor haplotype and neurodevelopmental delay at age 2 years in a cohort at risk for early preterm birth SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 01-06, 2010 CL Chicago, IL SP Soc Maternal Fetal Med C1 [Clark, Erin A. S.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Maternal Fetal Med Units Network, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2011 VL 204 SU 1 MA 66 BP S38 EP S38 DI 10.1016/j.ajog.2010.10.079 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 702WV UT WOS:000285927500067 ER PT J AU Conway, D Parker, A Carter, M Dudley, D Holden, A AF Conway, Deborah Parker, Ashley Carter, Margaret Dudley, Donald Holden, Alan TI Obesity is an independent risk factor for late preterm birth in San Antonio, Texas SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 01-06, 2010 CL Chicago, IL SP Soc Maternal Fetal Med C1 [Conway, Deborah] Eunice Kennedy Shriver NICHD SCRN, San Antonio, TX USA. [Parker, Ashley; Carter, Margaret; Dudley, Donald; Holden, Alan] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2011 VL 204 SU 1 MA 101 BP S55 EP S55 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 702WV UT WOS:000285927500102 ER PT J AU Conway, D AF Conway, Deborah TI Estimating Gestational age at stillbirth using clinical and pathologic data: the stillbirth collaborative research network algorithm SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 01-06, 2010 CL Chicago, IL SP Soc Maternal Fetal Med C1 [Conway, Deborah] Eunice Kennedy Shriver NICHD SCRN, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2011 VL 204 SU 1 MA 106 BP S56 EP S56 DI 10.1016/j.ajog.2010.10.122 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 702WV UT WOS:000285927500106 ER PT J AU Costantine, MM Clark, EAS AF Costantine, Maged M. Clark, Erin A. S. TI Oxidative stress, neuroprotection candidate gene polymorphisms and adverse neurodevelopmental outcomes SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 01-06, 2010 CL Chicago, IL SP Soc Maternal Fetal Med C1 [Costantine, Maged M.; Clark, Erin A. S.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, MFMU Network, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2011 VL 204 SU 1 MA 67 BP S38 EP S38 DI 10.1016/j.ajog.2010.10.080 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 702WV UT WOS:000285927500068 ER PT J AU Figueroa, D AF Figueroa, Dana TI Relationship between the 1-hour glucose loading test results and perinatal outcomes SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 01-06, 2010 CL Chicago, IL SP Soc Maternal Fetal Med C1 [Figueroa, Dana] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Maternal Fetal Med Units Network, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2011 VL 204 SU 1 MA 250 BP S107 EP S107 DI 10.1016/j.ajog.2010.10.268 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 702WV UT WOS:000285927500249 ER PT J AU Graves, SW Esplin, MS AF Graves, Steven W. Esplin, M. Sean TI Validation of predictive preterm birth biomarkers obtained by maternal serum proteomics SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 01-06, 2010 CL Chicago, IL SP Soc Maternal Fetal Med C1 [Graves, Steven W.; Esplin, M. Sean] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Maternal Fetal Med Units Network, Bethesda, MD USA. NR 0 TC 3 Z9 3 U1 0 U2 5 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2011 VL 204 SU 1 MA 80 BP S46 EP S46 DI 10.1016/j.ajog.2010.10.095 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 702WV UT WOS:000285927500081 ER PT J AU Harper, M AF Harper, Margaret TI Omega-3 fatty acids and cytokine production SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 01-06, 2010 CL Chicago, IL SP Soc Maternal Fetal Med C1 [Harper, Margaret] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Maternal Fetal Med Units Network, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2011 VL 204 SU 1 MA 507 BP S202 EP S203 PG 2 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 702WV UT WOS:000285927500505 ER PT J AU Harper, M AF Harper, Margaret TI Tumor necrosis factor alpha-308 genetic polymorphism and cytokine production SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 01-06, 2010 CL Chicago, IL SP Soc Maternal Fetal Med C1 [Harper, Margaret] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Maternal Fetal Med Units Network, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2011 VL 204 SU 1 MA 506 BP S202 EP S202 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 702WV UT WOS:000285927500504 ER PT J AU Harper, M AF Harper, Margaret TI Inflammatory cytokines and recurrent preterm birth SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 01-06, 2010 CL Chicago, IL SP Soc Maternal Fetal Med C1 [Harper, Margaret] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Maternal Fetal Med Units Network, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2011 VL 204 SU 1 MA 508 BP S203 EP S203 DI 10.1016/j.ajog.2010.10.527 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 702WV UT WOS:000285927500506 ER PT J AU Hauth, JC AF Hauth, John C. TI Maternal insulin resistance and preeclampsia SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 01-06, 2010 CL Chicago, IL SP Soc Maternal Fetal Med C1 [Hauth, John C.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Maternal Fetal Med Units Network, Bethesda, MD USA. NR 0 TC 2 Z9 2 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2011 VL 204 SU 1 MA 19 BP S12 EP S12 DI 10.1016/j.ajog.2010.10.027 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 702WV UT WOS:000285927500020 ER PT J AU Hauth, JC AF Hauth, John C. TI Insulin resistance in pregnancy and maternal body mass SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 01-06, 2010 CL Chicago, IL SP Soc Maternal Fetal Med C1 [Hauth, John C.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Maternal Fetal Med Units Network, Bethesda, MD USA. NR 0 TC 5 Z9 5 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2011 VL 204 SU 1 MA 815 BP S318 EP S318 DI 10.1016/j.ajog.2010.10.837 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 702WV UT WOS:000285927500812 ER PT J AU Hoffman, M Sciscione, A Laughon, SK Zhang, J Reddy, U AF Hoffman, Matthew Sciscione, Anthony Laughon, S. Katherine Zhang, Jun Reddy, Uma TI The duration of labor induction and maternal and neonatal outcomes SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 01-06, 2010 CL Chicago, IL SP Soc Maternal Fetal Med C1 [Hoffman, Matthew] Christiana Care Hlth Syst, Newark, DE USA. [Sciscione, Anthony] Christiana Hosp, Newark, DE USA. [Laughon, S. Katherine] Div Epidemiol Stat & Prevent Res, Bethesda, MD USA. [Zhang, Jun] NICHHD, Bethesda, MD 20892 USA. [Reddy, Uma] Pregnancy & Perinatol Branch, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2011 VL 204 SU 1 MA 294 BP S122 EP S122 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 702WV UT WOS:000285927500293 ER PT J AU Johnson, J AF Johnson, Julie TI Outcomes associated with failure to achieve the 2009 Institute of Medicine (IOM) guidelines for weight gain in pregnancy SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 01-06, 2010 CL Chicago, IL SP Soc Maternal Fetal Med C1 [Johnson, Julie] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Maternal Fetal Med Units Network, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2011 VL 204 SU 1 MA 582 BP S232 EP S232 DI 10.1016/j.ajog.2010.10.602 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 702WV UT WOS:000285927500580 ER PT J AU Laughon, SK Zhang, J Troendle, J Reddy, U AF Laughon, S. Katherine Zhang, Jun Troendle, James Reddy, Uma TI Simplifying the bishop score SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 01-06, 2010 CL Chicago, IL SP Soc Maternal Fetal Med C1 [Laughon, S. Katherine] Div Epidemiol Stat & Prevent Res, Bethesda, MD USA. [Zhang, Jun; Troendle, James] NICHHD, Bethesda, MD 20892 USA. [Reddy, Uma] Pregnancy & Perinatol Branch, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2011 VL 204 SU 1 MA 319 BP S131 EP S132 DI 10.1016/j.ajog.2010.10.337 PG 3 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 702WV UT WOS:000285927500318 ER PT J AU Makhlouf, M AF Makhlouf, Michel TI Adverse pregnancy outcomes among women with prior spontaneous or induced abortions SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 01-06, 2010 CL Chicago, IL SP Soc Maternal Fetal Med C1 [Makhlouf, Michel] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Maternal Fetal Med Units Network, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 5 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2011 VL 204 SU 1 MA 513 BP S204 EP S205 DI 10.1016/j.ajog.2010.10.532 PG 2 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 702WV UT WOS:000285927500511 ER PT J AU Peaceman, A AF Peaceman, Alan TI Duration of latency after PPROM by gestational age at time of membrane rupture SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 01-06, 2010 CL Chicago, IL SP Soc Maternal Fetal Med C1 [Peaceman, Alan] NICHHD, Maternal Fetal Med Units Network, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2011 VL 204 SU 1 MA 456 BP S183 EP S183 DI 10.1016/j.ajog.2010.10.475 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 702WV UT WOS:000285927500455 ER PT J AU Rana, S Karumanchi, A Wang, A Powe, C Ecker, J Thadhani, R Levine, R AF Rana, Sarosh Karumanchi, Ananth Wang, Alice Powe, Camille Ecker, Jeffery Thadhani, Ravi Levine, Richard TI Preeclampsia is not independently associated with large for gestational age infants SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 01-06, 2010 CL Chicago, IL SP Soc Maternal Fetal Med C1 [Rana, Sarosh; Karumanchi, Ananth] Harvard Univ, Sch Med, BIDMC, Boston, MA USA. [Wang, Alice] Boston Med Ctr, Boston, MA USA. [Powe, Camille; Ecker, Jeffery; Thadhani, Ravi] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Levine, Richard] NICHD, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2011 VL 204 SU 1 MA 244 BP S105 EP S105 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 702WV UT WOS:000285927500243 ER PT J AU Roberson, R Kuddo, T Benassou, I Spong, C AF Roberson, Robin Kuddo, Thea Benassou, Ines Spong, Catherine TI Cytokine alterations in fetal alcohol syndrome SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 01-06, 2010 CL Chicago, IL SP Soc Maternal Fetal Med C1 [Roberson, Robin; Kuddo, Thea; Benassou, Ines; Spong, Catherine] NICHD, UPDN, DIR, NIH, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 4 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2011 VL 204 SU 1 MA 453 BP S182 EP S182 DI 10.1016/j.ajog.2010.10.472 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 702WV UT WOS:000285927500452 ER PT J AU Roberson, R Kuddo, T Benassou, I Abebe, D Spong, C AF Roberson, Robin Kuddo, Thea Benassou, Ines Abebe, Daniel Spong, Catherine TI Neuroprotective fractalkine in fetal alcohol syndrome SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 01-06, 2010 CL Chicago, IL SP Soc Maternal Fetal Med C1 [Roberson, Robin; Kuddo, Thea; Benassou, Ines; Abebe, Daniel; Spong, Catherine] UPDN DIR NICHD NIH, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2011 VL 204 SU 1 MA 53 BP S32 EP S32 DI 10.1016/j.ajog.2010.10.065 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 702WV UT WOS:000285927500054 ER PT J AU Saade, G AF Saade, George CA Eunice Kennedy Shriver NICHD SCRN TI Risk of stillbirth according to second trimester aneuploidy screen result in the Stillbirth Collaborative Research Network: a population-based study SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 01-06, 2010 CL Chicago, IL SP Soc Maternal Fetal Med C1 [Eunice Kennedy Shriver NICHD SCRN] NICHD, Bethesda, MD USA. [Saade, George] Univ Texas Med Branch, Galveston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2011 VL 204 SU 1 MA 62 BP S37 EP S37 DI 10.1016/j.ajog.2010.10.075 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 702WV UT WOS:000285927500063 ER PT J AU Stuebe, A AF Stuebe, Alison TI Maternal BMI, glucose tolerance, and adverse pregnancy outcomes SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 01-06, 2010 CL Chicago, IL SP Soc Maternal Fetal Med C1 [Stuebe, Alison] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Maternal Fetal Med Units Network, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2011 VL 204 SU 1 MA 537 BP S215 EP S215 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 702WV UT WOS:000285927500535 ER PT J AU Stuebe, A AF Stuebe, Alison TI Is there a threshold OGTT value for predicting adverse neonatal outcome? SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 01-06, 2010 CL Chicago, IL SP Soc Maternal Fetal Med C1 [Stuebe, Alison] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Maternal Fetal Med Units Network, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2011 VL 204 SU 1 MA 538 BP S215 EP S215 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 702WV UT WOS:000285927500536 ER PT J AU VanVeldhuisen, P Zhang, J Troendle, J Beaver, J Kominiarek, M Hibbard, J AF VanVeldhuisen, Paul Zhang, Jun Troendle, James Beaver, Julie Kominiarek, Michelle Hibbard, Judith TI Contemporary labor patterns: the impact of maternal body mass index SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 01-06, 2010 CL Chicago, IL SP Soc Maternal Fetal Med C1 [VanVeldhuisen, Paul] EMMES Corp, Rockville, MD USA. [Zhang, Jun; Troendle, James; Beaver, Julie] NICHHD, Bethesda, MD 20892 USA. [Kominiarek, Michelle; Hibbard, Judith] Univ Illinois, Chicago, IL USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2011 VL 204 SU 1 MA 82 BP S47 EP S47 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 702WV UT WOS:000285927500083 ER PT J AU Varner, M AF Varner, Michael TI Umbilical cord homogenate toxicology and serum cotinine levels in stillbirths and live births SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 01-06, 2010 CL Chicago, IL SP Soc Maternal Fetal Med C1 [Varner, Michael] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Maternal Fetal Med Units Network, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2011 VL 204 SU 1 MA 591 BP S235 EP S236 DI 10.1016/j.ajog.2010.10.611 PG 4 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 702WV UT WOS:000285927500589 ER PT J AU Varner, M AF Varner, Michael TI Influenza-like illness in hospitalized pregnant and immediately postpartum women during the 2009-2010 H1N1 influenza pandemic SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 30th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 01-06, 2010 CL Chicago, IL SP Soc Maternal Fetal Med C1 [Varner, Michael] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Maternal Fetal Med Units Network, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2011 VL 204 SU 1 MA 75 BP S43 EP S43 DI 10.1016/j.ajog.2010.10.089 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 702WV UT WOS:000285927500076 ER PT J AU Baird, DD Steiner, AZ AF Baird, Donna Day Steiner, Anne Z. TI Anti-mullerian hormone (AMH) and repetitive oocyte donation SO FERTILITY AND STERILITY LA English DT Letter C1 [Baird, Donna Day] NIEHS, NIH, Res Triangle Pk, NC 27709 USA. [Steiner, Anne Z.] Univ N Carolina, Dept Obstet & Gynecol, Chapel Hill, NC USA. RP Baird, DD (reprint author), NIEHS, NIH, POB 12233, Res Triangle Pk, NC 27709 USA. RI Baird, Donna/D-5214-2017 OI Baird, Donna/0000-0002-5544-2653 NR 2 TC 0 Z9 0 U1 3 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD JAN PY 2011 VL 95 IS 1 BP E5 EP E5 DI 10.1016/j.fertnstert.2010.09.051 PG 1 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 695ZL UT WOS:000285411600005 PM 21074151 ER PT J AU Kitamura, K Farber, J Kelsall, B AF Kitamura, K. Farber, J. Kelsall, B. TI Possible role for CCR6+regulatory T cell in the T cell-transfer model of colitis SO INFLAMMATORY BOWEL DISEASES LA English DT Meeting Abstract CT Advances in Inflammatory Bowel Diseases Crohns and Colitis Foundations National Clinical and Research Conference CY DEC 09-12, 2010 CL Hollywood, FL C1 [Kitamura, K.] Kanazawa Univ, Kanazawa, Ishikawa, Japan. [Kitamura, K.; Farber, J.; Kelsall, B.] NIAID, LMI, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1078-0998 J9 INFLAMM BOWEL DIS JI Inflamm. Bowel Dis. PD JAN PY 2011 VL 17 SU 1 BP S5 EP S5 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 693WO UT WOS:000285256300018 ER PT J AU Meylan, F Song, Y Fuss, I Villarreal, S Kahle, E Malm, I Acharya, K Ramos, H Lo, L Mentink-Kane, M Wynn, T Migone, T Strober, W Siegel, R AF Meylan, F. Song, Y. Fuss, I Villarreal, S. Kahle, E. Malm, I Acharya, K. Ramos, H. Lo, L. Mentink-Kane, M. Wynn, T. Migone, T. Strober, W. Siegel, R. TI The TNF-family cytokine TL1A drives IL-13-dependent small intestinal inflammation. SO INFLAMMATORY BOWEL DISEASES LA English DT Meeting Abstract CT Advances in Inflammatory Bowel Diseases Crohns and Colitis Foundations National Clinical and Research Conference CY DEC 09-12, 2010 CL Hollywood, FL C1 [Meylan, F.; Song, Y.; Villarreal, S.; Kahle, E.; Malm, I; Acharya, K.; Ramos, H.; Siegel, R.] NIAMS, NIH, Bethesda, MD USA. [Fuss, I; Strober, W.] NIAID, LHD, NIH, Bethesda, MD 20892 USA. [Lo, L.; Migone, T.] HGS, Rockville, MD USA. [Mentink-Kane, M.; Wynn, T.] NIAID, LPD, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1078-0998 J9 INFLAMM BOWEL DIS JI Inflamm. Bowel Dis. PD JAN PY 2011 VL 17 SU 1 BP S16 EP S16 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 693WO UT WOS:000285256300050 ER PT J AU Best, AM Chang, JJ Dull, AB Beutler, JA Martinez, ED AF Best, Anne M. Chang, Jianjun Dull, Angie B. Beutler, John A. Martinez, Elisabeth D. TI Identification of Four Potential Epigenetic Modulators from the NCI Structural Diversity Library Using a Cell-Based Assay SO JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY LA English DT Article ID HISTONE DEACETYLASE INHIBITOR; SMALL-MOLECULE INHIBITOR; REFRACTORY SOLID TUMORS; CANCER; LYMPHOMA; THERAPY; VORINOSTAT; EXPRESSION; ENZYMES AB Epigenetic pathways help control the expression of genes. In cancer and other diseases, aberrant silencing or overexpression of genes, such as those that control cell growth, can greatly contribute to pathogenesis. Access to these genes by the transcriptional machinery is largely mediated by chemical modifications of DNA or histones, which are controlled by epigenetic enzymes, making these enzymes attractive targets for drug discovery. Here we describe the characterization of a locus derepression assay, a fluorescence-based mammalian cellular system which was used to screen the NCI structural diversity library for novel epigenetic modulators using an automated imaging platform. Four structurally unique compounds were uncovered that, when further investigated, showed distinct activities. These compounds block the viability of lung cancer and melanoma cells, prevent cell cycle progression, and/or inhibit histone deacetylase activity, altering levels of cellular histone acetylation. C1 [Best, Anne M.; Chang, Jianjun; Martinez, Elisabeth D.] Univ Texas SW Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA. [Best, Anne M.; Chang, Jianjun; Martinez, Elisabeth D.] Univ Texas SW Med Ctr Dallas, Hamon Ctr Therapeut Oncol Res, Dallas, TX 75390 USA. [Dull, Angie B.] NCI, Mol Targets Lab, Ctr SAIC Frederick, Frederick, MD 21702 USA. [Beutler, John A.] NCI, Mol Targets Lab, Ctr Canc Res, Dallas, TX 75390 USA. RP Martinez, ED (reprint author), Univ Texas SW Med Ctr Dallas, Dept Pharmacol, 6000 Harry Hines Blvd, Dallas, TX 75390 USA. EM elisabeth.martinez@utsouthwestern.edu RI Beutler, John/B-1141-2009 OI Beutler, John/0000-0002-4646-1924 FU NCI [P50-CA70907, K22CA118717-01]; Doctors Cancer Foundation; National Cancer Institute, National Institutes of Health [HHSN26120080001E]; NIH, National Cancer Institute, Center for Cancer Research FX The authors are grateful to Drs. Gordon Hager, John Minna, and Jerry Niederkorn for the generous gift of cell lines. The authors are indebted to Dr. George E. Rottinghaus for the kind gift of secalonic acid D and to Dr. David Schump for providing depsipeptide. This study was partly supported by the NCI (through a career development Award under P50-CA70907, University of Texas SPORE in Lung Cancer to E.D. Martinez, and through K22CA118717-01 Grant to E.D. Martinez) and by the Doctors Cancer Foundation (Nolan Miller Lung Cancer grant to E.D. Martinez). This project has been funded in whole or in part with federal funds from the National Cancer Institute, National Institutes of Health, under Contract no. HHSN26120080001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. This Research was supported in part by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research. NR 35 TC 9 Z9 9 U1 1 U2 3 PU HINDAWI PUBLISHING CORPORATION PI NEW YORK PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA SN 1110-7243 J9 J BIOMED BIOTECHNOL JI J. Biomed. Biotechnol. PY 2011 AR 868095 DI 10.1155/2011/868095 PG 11 WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental SC Biotechnology & Applied Microbiology; Research & Experimental Medicine GA 706WI UT WOS:000286248100001 ER PT J AU Smith, HA Maricque, BB Eberhardt, J Petersen, B Gulley, JL Schlom, J McNeel, DG AF Smith, Heath A. Maricque, Brett B. Eberhardt, John Petersen, Benjamin Gulley, James L. Schlom, Jeffrey McNeel, Douglas G. TI IgG Responses to Tissue-Associated Antigens as Biomarkers of Immunological Treatment Efficacy SO JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY LA English DT Article ID PROSTATE-CANCER PATIENTS; IMMUNE-RESPONSES; TESTIS ANTIGEN; VACCINE; IDENTIFICATION; BLOCKADE; PSA AB We previously demonstrated that IgG responses to a panel of 126 prostate tissue-associated antigens are common in patients with prostate cancer. In the current report we questioned whether changes in IgG responses to this panel might be used as a measure of immune response, and potentially antigen spread, following prostate cancer-directed immune-active therapies. Sera were obtained from prostate cancer patients prior to and three months following treatment with androgen deprivation therapy (n = 34), a poxviral vaccine (n = 31), and a DNA vaccine (n = 21). Changes in IgG responses to individual antigens were identified by phage immunoblot. Patterns of IgG recognition following three months of treatment were evaluated using a machine-learned Bayesian Belief Network (ML-BBN). We found that different antigens were recognized following androgen deprivation compared with vaccine therapies. While the number of clinical responders was low in the vaccine-treated populations, we demonstrate that ML-BBN can be used to develop potentially predictive models. C1 [Smith, Heath A.; Maricque, Brett B.; McNeel, Douglas G.] Univ Wisconsin, Carbone Comprehens Canc Ctr, Madison, WI 53705 USA. [Eberhardt, John; Petersen, Benjamin] DecisionQ Corp, Washington, DC 20007 USA. [Gulley, James L.; Schlom, Jeffrey] NCI, Tumor Immunol & Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. [McNeel, Douglas G.] 7007 Wisconsin Inst Med Res, Madison, WI 53705 USA. RP McNeel, DG (reprint author), Univ Wisconsin, Carbone Comprehens Canc Ctr, 1111 Highland Ave, Madison, WI 53705 USA. EM dm3@medicine.wisc.edu RI Gulley, James/K-4139-2016 OI Gulley, James/0000-0002-6569-2912 FU NIH [K23 RR16489]; US Army Medical Research and Materiel Command [W81XWH-06-1-0184] FX This work was supported by NIH (K23 RR16489), and by the US Army Medical Research and Materiel Command Prostate Cancer Research program (W81XWH-06-1-0184). NR 23 TC 6 Z9 6 U1 0 U2 0 PU HINDAWI PUBLISHING CORPORATION PI NEW YORK PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA SN 1110-7243 J9 J BIOMED BIOTECHNOL JI J. Biomed. Biotechnol. PY 2011 AR 454861 DI 10.1155/2011/454861 PG 10 WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental SC Biotechnology & Applied Microbiology; Research & Experimental Medicine GA 706RX UT WOS:000286236600001 ER PT S AU You, D Antani, S Demner-Fushman, D Govindaraju, V Thoma, GR AF You, Daekeun Antani, Sameer Demner-Fushman, Dina Govindaraju, Venu Thoma, George R. GP IEEE TI Detecting Figure-panel Labels in Medical Journal Articles using MRF SO 11TH INTERNATIONAL CONFERENCE ON DOCUMENT ANALYSIS AND RECOGNITION (ICDAR 2011) SE Proceedings of the International Conference on Document Analysis and Recognition LA English DT Proceedings Paper CT 11th International Conference on Document Analysis and Recognition (ICDAR) CY SEP 18-21, 2011 CL Beijing, PEOPLES R CHINA SP Chinese Acad Sci, FOUNDER, NSFC, FUJITSU, Hanvon Technol, Green Apple Data Ctr, ABBYY, Raytheon BBN Technologies, Nuance, A2iA, ITESOFT, Int Assoc Pattern Recognit, TC10 Graph Recognit & TC11 Reading Syst, CAA, Tsinghua Univ, CASIA, HITACHI DE image-text detection; Markov Random Field; belief propagation; OCR; Neural network; image binarization; CBIR; image classification AB We present a method for figure-panel (subfigure) label detection and recognition in multi-panel figures extracted from biomedical articles. Figures in biomedical articles often comprise several subfigures that are identified by superimposed panel labels (`A', `B', ...) which are referenced in the figure caption and discussion in the article body. Splitting such multi-panel figures into individual subfigures is a necessary step for improved multimodal biomedical information retrieval. Prior to feature extraction for indexing and retrieval of biomedical figures it is necessary to classify image content in each subfigure by its modality (X-ray, MRI, CT, etc.) and other relevant criteria. Subfigure labels are valuable in associating individual panels with relevant text in captions and discussion. We propose a 4-step panel label detection method based on Markov Random Field (MRF). Experiments on 515 multi-panel figures and analysis of the results show promising results. We present the successes and identify critical challenges. C1 [You, Daekeun; Govindaraju, Venu] SUNY Buffalo, Ctr Unified Biometr & Sensors, Dept Comp Sci & Engn, Buffalo, NY 14260 USA. [Antani, Sameer; Demner-Fushman, Dina; Thoma, George R.] NIH, Natl Lib Medicine, Bethesda, MD 20894 USA. RP You, D (reprint author), SUNY Buffalo, Ctr Unified Biometr & Sensors, Dept Comp Sci & Engn, Buffalo, NY 14260 USA. EM dyou@buffalo.edu; santani@mail.nih.gov; ddemner@mail.nih.gov; govind@buffalo.edu; gthoma@mail.nih.gov OI Antani, Sameer/0000-0002-0040-1387 FU Intramural Research Program of the National Institutes of Health (NIH); National Library of Medicine (NLM); Lister Hill National Center for Biomedical Communications (LHNCBC) FX This research is supported by the Intramural Research Program of the National Institutes of Health (NIH), National Library of Medicine (NLM), and Lister Hill National Center for Biomedical Communications (LHNCBC). We would like to thank the CLEF [8] organizers for making the database available for the experiments. NR 9 TC 1 Z9 1 U1 0 U2 0 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 USA SN 1520-5363 BN 978-0-7695-4520-2 J9 PROC INT CONF DOC PY 2011 BP 967 EP 971 DI 10.1109/ICDAR.2011.196 PG 5 WC Computer Science, Artificial Intelligence; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BB4XG UT WOS:000343450700190 ER PT S AU Bourbakis, N Makrogiannis, S Kapogiannis, D AF Bourbakis, N. Makrogiannis, S. Kapogiannis, D. GP IEEE TI A Synergistic Model for Monitoring Brain's Changes: A Case Study SO 2011 23RD IEEE INTERNATIONAL CONFERENCE ON TOOLS WITH ARTIFICIAL INTELLIGENCE (ICTAI 2011) SE Proceedings-International Conference on Tools With Artificial Intelligence LA English DT Proceedings Paper CT 23rd IEEE International Conference on Tools with Artificial Intelligence (ICTAI) CY NOV 07-09, 2011 CL Boca Raton, FL SP IEEE, IEEE Comp Soc, IEEE Comp Soc Tech Comm Multimedia Comp (TCMC), Bio & Artificial Intelligence Soc (BAIS), Florida Atlant Univ (FAU), Univ Technol, Ctr Quantum Comp & Intelligent Syst (UTS-QCIS), Tsinghua Univ, Arnetminer ID IMAGES AB It is known that the early detection of chronic diseases significantly increases the life span of the elderly and improves the quality of life in general. Since the brain is the most valuable part of the human body, it is very important for the physicians to know the stages of aging and changes that take place during these stages and possible implications associated with them in order to more effectively treat their patients. In addition, fMRI provides information (size, density, location, etc) from brain images for the active regions during thinking and/or performing certain tasks. Thus, in this paper a monitoring brain-aging model based on a synergy of methodologies, like image segmentation, registration, local global (L-G) graphs and stochastic Petri net (SPN) graphs is presented. In particular, the synergistic brain-aging model uses fMRI images to detect, extract and associate the way that the brain regions interact regarding thinking and/or executing certain tasks. These brain-region images are extracted and geometrically are represented and associated with the L-G graphs. Then the use of SPN graphs models the regions' functionality. Thus, comparing the L-G and SPN graphs extracted from fMRI images taken in different periods from the same subject, the model has the capability to detect changes and associate them in order the medical expert to monitor the health status and provide a diagnosis or prognosis regarding a human subject. Sets of L-G and SPN graph models generated in time for each particular subject are available in an L-G/SPN graph Database. Here the synergistic model and its proof of concept are presented. C1 [Bourbakis, N.] Wright State Univ, ATR Ctr, Dayton, OH 45435 USA. [Bourbakis, N.] AIIS Inc, Centerville, Ohio. [Makrogiannis, S.; Kapogiannis, D.] NIA, Baltimore, MD 21218 USA. RP Bourbakis, N (reprint author), Wright State Univ, ATR Ctr, Dayton, OH 45435 USA. NR 8 TC 0 Z9 0 U1 0 U2 2 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 USA SN 1082-3409 BN 978-0-7695-4596-7 J9 PROC INT C TOOLS ART PY 2011 BP 1093 EP 1098 DI 10.1109/ICTAI.2011.186 PG 6 WC Computer Science, Artificial Intelligence; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BYJ28 UT WOS:000299009900179 ER PT S AU Nandy, K Gudla, PR Amundsen, R Meaburn, KJ Misteli, T Lockett, SJ AF Nandy, Kaustav Gudla, Prabhakar R. Amundsen, Ryan Meaburn, Karen J. Misteli, Tom Lockett, Stephen J. GP IEEE TI Supervised Learning Framework For Screening Nuclei in Tissue Sections SO 2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) SE IEEE Engineering in Medicine and Biology Society Conference Proceedings LA English DT Proceedings Paper CT 33rd Annual International Conference of the IEEE Engineering-in-Medicine-and-Biology-Society (EMBS) CY AUG 30-SEP 03, 2011 CL Boston, MA SP IEEE, Engn Med & Biol Soc (EMBS) ID AUTOMATIC SEGMENTATION; IMAGES AB Accurate segmentation of cell nuclei in microscope images of tissue sections is a key step in a number of biological and clinical applications. Often such applications require analysis of large image datasets for which manual segmentation becomes subjective and time consuming. Hence automation of the segmentation steps using fast, robust and accurate image analysis and pattern classification techniques is necessary for high throughput processing of such datasets. We describe a supervised learning framework, based on artificial neural networks (ANNs), to identify well-segmented nuclei in tissue sections from a multistage watershed segmentation algorithm. The successful automation was demonstrated by screening over 1400 well segmented nuclei from 9 datasets of human breast tissue section images and comparing the results to a previously used stacked classifier based analysis framework. C1 [Nandy, Kaustav; Gudla, Prabhakar R.; Lockett, Stephen J.] NCI Frederick, Opt Microscopy & Anal Lab, Adv Technol Program, SAIC Frederick Inc, Frederick, MD 21702 USA. RP Nandy, K (reprint author), NCI Frederick, Opt Microscopy & Anal Lab, Adv Technol Program, SAIC Frederick Inc, Frederick, MD 21702 USA. EM nandyk@mail.nih.gov; gudlap@mail.nih.gov; ryan.j.amundsen@gmail.com; meaburnk@mail.nih.gov; mistelit@mail.nih.gov; locketts@mail.nih.gov OI Meaburn, Karen/0000-0002-1327-5957 NR 15 TC 1 Z9 1 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1557-170X BN 978-1-4244-4122-8 J9 IEEE ENG MED BIO PY 2011 BP 5989 EP 5992 PG 4 WC Engineering, Biomedical; Engineering, Electrical & Electronic SC Engineering GA BYH52 UT WOS:000298810004227 ER PT S AU Caban, JJ Yao, JH Bagci, U Mollura, DJ AF Caban, Jesus J. Yao, Jianhua Bagci, Ulas Mollura, Daniel J. GP IEEE TI Monitoring Pulmonary Fibrosis by Fusing Clinical, Physiological, and Computed Tomography Features SO 2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) SE IEEE Engineering in Medicine and Biology Society Conference Proceedings LA English DT Proceedings Paper CT 33rd Annual International Conference of the IEEE Engineering-in-Medicine-and-Biology-Society (EMBS) CY AUG 30-SEP 03, 2011 CL Boston, MA SP IEEE, Engn Med & Biol Soc (EMBS) AB Advances in medical imaging and screening tests have made possible the detection and diagnosis of many diseases in their early stages. Those advances have enabled more effective planning, execution, and monitoring of a treatment plan. However, early detection has also resulted in an increase of the number of longitudinal radiographs requested for most patients, thus increasing the risk for potential long-term effects of ionizing radiation exposure and increasing the cost associated with a specific treatment plan. The aim of this paper is to study the associations between clinical measurements and quantitative image features in patients with pulmonary fibrosis. The association between these multi-modal features could be used to more accurately determine the state of the disease and could potentially be used to predict many of the longitudinal image features when CT images are not available. Our results show how textural image features are highly correlated with the severity of fibrosis, how clinical variables can be combined to monitor progression, and how simple blood features can be used to predict statistical image attributes of the lungs. C1 [Caban, Jesus J.] NIH, Natl Lib Med, Bethesda, MD 20894 USA. RP Caban, JJ (reprint author), NIH, Natl Lib Med, Bethesda, MD 20894 USA. EM jesus.caban@nih.gov OI Bagci, Ulas/0000-0001-7379-6829 NR 9 TC 3 Z9 3 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1557-170X BN 978-1-4244-4122-8 J9 IEEE ENG MED BIO PY 2011 BP 6216 EP 6219 PG 4 WC Engineering, Biomedical; Engineering, Electrical & Electronic SC Engineering GA BYH52 UT WOS:000298810004282 ER PT S AU Bagci, U Yao, JH Caban, J Turkbey, E Aras, O Mollura, DJ AF Bagci, Ulas Yao, Jianhua Caban, Jesus Turkbey, Evrim Aras, Omer Mollura, Daniel J. GP IEEE TI A Graph-Theoretic Approach for Segmentation of PET Images SO 2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) SE IEEE Engineering in Medicine and Biology Society Conference Proceedings LA English DT Proceedings Paper CT 33rd Annual International Conference of the IEEE Engineering-in-Medicine-and-Biology-Society (EMBS) CY AUG 30-SEP 03, 2011 CL Boston, MA SP IEEE, Engn Med & Biol Soc (EMBS) ID VOLUME AB Segmentation of positron emission tomography (PET) images is an important objective because accurate measurement of signal from radio-tracer activity in a region of interest is critical for disease treatment and diagnosis. In this study, we present the use of a graph based method for providing robust, accurate, and reliable segmentation of functional volumes on PET images from standardized uptake values (SUVs). We validated the success of the segmentation method on different PET phantoms including ground truth CT simulation, and compared it to two well-known threshold based segmentation methods. Furthermore, we assessed intra- and inter-observer variation in delineation accuracy as well as reproducibility of delineations using real clinical data. Experimental results indicate that the presented segmentation method is superior to the commonly used threshold based methods in terms of accuracy, robustness, repeatability, and computational efficiency. C1 [Bagci, Ulas; Mollura, Daniel J.] NIH, Ctr Infect Dis Imaging, Bethesda, MD 20892 USA. [Bagci, Ulas; Yao, Jianhua; Turkbey, Evrim; Aras, Omer; Mollura, Daniel J.] NIH, Dept Radiol & Imag Sci, Bethesda, MD 20892 USA. [Caban, Jesus] NIH, Natl Lib Med, Bethesda, MD 20892 USA. [Aras, Omer] Univ Maryland Med Syst, Dept Radiol Nucl Med, Baltimore, MD USA. RP Bagci, U (reprint author), NIH, Ctr Infect Dis Imaging, Bethesda, MD 20892 USA. EM ulas.bagci@nih.gov OI Bagci, Ulas/0000-0001-7379-6829 NR 11 TC 16 Z9 16 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1557-170X BN 978-1-4244-4122-8 J9 IEEE ENG MED BIO PY 2011 BP 8479 EP 8482 PG 4 WC Engineering, Biomedical; Engineering, Electrical & Electronic SC Engineering GA BYH52 UT WOS:000298810006150 ER PT S AU Kim, J Park, HS Damiano, DL AF Kim, Jonghyun Park, Hyung-Soon Damiano, Diane L. GP IEEE TI Accuracy and Reliability of Haptic Spasticity Assessment Using HESS (Haptic Elbow Spasticity Simulator) SO 2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) SE IEEE Engineering in Medicine and Biology Society Conference Proceedings LA English DT Proceedings Paper CT 33rd Annual International Conference of the IEEE Engineering-in-Medicine-and-Biology-Society (EMBS) CY AUG 30-SEP 03, 2011 CL Boston, MA SP IEEE, Engn Med & Biol Soc (EMBS) ID MODIFIED ASHWORTH SCALE; MODIFIED TARDIEU SCALE; SEVERE BRAIN-INJURY; INTERRATER RELIABILITY; CEREBRAL-PALSY; CHILDREN AB Clinical assessment of spasticity tends to be subjective because of the nature of the in-person assessment; severity of spasticity is judged based on the muscle tone felt by a clinician during manual manipulation of a patient's limb. As an attempt to standardize the clinical assessment of spasticity, we developed HESS (Haptic Elbow Spasticity Simulator), a programmable robotic system that can provide accurate and consistent haptic responses of spasticity and thus can be used as a training tool for clinicians. The aim of this study is to evaluate the accuracy and reliability of the recreated haptic responses. Based on clinical data collected from children with cerebral palsy, four levels of elbow spasticity (1, 1+, 2, and 3 in the Modified Ashworth Scale [MAS]) were recreated by HESS. Seven experienced clinicians manipulated HESS to score the recreated haptic responses. The accuracy of the recreation was assessed by the percent agreement between intended and determined MAS scores. The inter-rater reliability among the clinicians was analyzed by using Fleiss's kappa. In addition, the level of realism with the recreation was evaluated by a questionnaire on "how realistic" this felt in a qualitative way. The percent agreement was high (85.7 +/- 11.7%), and for inter-rater reliability, there was substantial agreement (kappa=0.646) among the seven clinicians. The level of realism was 7.71 +/- 0.95 out of 10. These results show that the haptic recreation of spasticity by HESS has the potential to be used as a training tool for standardizing and enhancing reliability of clinical assessment. C1 [Kim, Jonghyun; Park, Hyung-Soon; Damiano, Diane L.] NIH, Dept Rehabil Med, Ctr Clin, Bethesda, MD 20892 USA. RP Park, HS (reprint author), NIH, Dept Rehabil Med, Ctr Clin, Bethesda, MD 20892 USA. EM parkhs@cc.nih.gov RI Damiano, Diane/B-3338-2010 OI Damiano, Diane/0000-0002-2770-5356 NR 18 TC 2 Z9 2 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1557-170X BN 978-1-4244-4122-8 J9 IEEE ENG MED BIO PY 2011 BP 8527 EP 8530 PG 4 WC Engineering, Biomedical; Engineering, Electrical & Electronic SC Engineering GA BYH52 UT WOS:000298810006162 ER PT S AU Chen, Y Wierwille, J Roney, CA Xu, BY Griffiths, GL Summers, RM AF Chen, Yu Wierwille, Jeremiah Roney, Celeste A. Xu, Biying Griffiths, Gary L. Summers, Ronald M. GP IEEE TI Combined OCT and Fluorescence Imaging for Cancer Detection and Therapeutic Monitoring SO 2011 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO) SE Conference on Lasers and Electro-Optics LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics (CLEO) CY MAY 01-06, 2011 CL Baltimore, MD ID OPTICAL COHERENCE TOMOGRAPHY AB We developed a co-registered optical coherence tomography (OCT) and fluorescence molecular imaging (FMI) system for simultaneous morphological and molecular imaging. This system enables real-time imaging of fluorescence-labeled gold nanoparticles and monitoring photothermal therapy. (C) 2011 Optical Society of America C1 [Chen, Yu; Wierwille, Jeremiah] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA. [Roney, Celeste A.; Summers, Ronald M.] NIH, Dept Radiol & Imaging Sci, Clin Sci, Bethesda, MD 20892 USA. [Xu, Biying; Griffiths, Gary L.] NIH, Natl Heart Lung & Blood Inst, Imaging Probe Dev Ctr, Bethesda, MD 20892 USA. RP Chen, Y (reprint author), Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA. EM yuchen@umd.edu NR 5 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2160-9020 BN 978-1-55752-910-7 J9 CONF LASER ELECTR PY 2011 PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BXB77 UT WOS:000295612402237 ER PT S AU Park, HS Kim, J Damiano, DL AF Park, Hyung-Soon Kim, Jonghyun Damiano, Diane L. GP IEEE TI Haptic Recreation of Elbow Spasticity SO 2011 IEEE INTERNATIONAL CONFERENCE ON REHABILITATION ROBOTICS (ICORR) SE International Conference on Rehabilitation Robotics ICORR LA English DT Proceedings Paper CT IEEE International Conference on Rehabilitation Robotics (ICORR)/International Neurorehabilitation Symposium (INRS)/International Conference on Virtual Rehabilitation (ICVR) CY JUN 27-JUL 01, 2011 CL ETH Zurich, Zurich, SWITZERLAND SP IEEE, RA, EMB, Hocoma, You Rehab, Int Soc Virtual Rehabil (ISVR), Zentrum Ambulante Rehabil, MUNDUS, RITZ HO ETH Zurich DE Elbow spasticity; Haptic device; Modified Ashworth Scale ID CEREBRAL-PALSY; ASHWORTH SCALE; CHILDREN; PATHOPHYSIOLOGY; RELIABILITY AB The aim of this paper is to develop a haptic device capable of presenting standardized recreation of elbow spasticity. Using the haptic device, clinicians will be able to repeatedly practice the assessment of spasticity without requiring patient involvement, and these practice opportunities will help improve accuracy and reliability of the assessment itself. Haptic elbow spasticity simulator (HESS) was designed and prototyped according to mechanical requirements to recreate the feel of elbow spasticity. Based on the data collected from subjects with elbow spasticity, a mathematical model representing elbow spasticity is proposed. As an attempt to differentiate the feel of each score in Modified Ashworth Scale (MAS), parameters of the model were obtained respectively for three different MAS scores 1, 1+, and 2. The implemented haptic recreation was evaluated by experienced clinicians who were asked to give MAS scores by manipulating the haptic device. The clinicians who participated in the study were blinded to each other's scores and to the given models. They distinguished the three models and the MAS scores given to the recreated models matched 100% with the original MAS scores from the patients. C1 [Park, Hyung-Soon; Kim, Jonghyun; Damiano, Diane L.] NIH, Dept Rehabil Med, Ctr Clin, Funct & Appl Biomech Sect, Bethesda, MD 20892 USA. RP Park, HS (reprint author), NIH, Dept Rehabil Med, Ctr Clin, Funct & Appl Biomech Sect, Bethesda, MD 20892 USA. EM parkhs@cc.nih.gov RI Damiano, Diane/B-3338-2010 OI Damiano, Diane/0000-0002-2770-5356 NR 20 TC 0 Z9 0 U1 1 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1945-7898 BN 978-1-4244-9862-8 J9 INT C REHAB ROBOT PY 2011 PG 6 WC Robotics; Rehabilitation SC Robotics; Rehabilitation GA BYK51 UT WOS:000299169800124 ER PT S AU Khwaja, AM Daruwalla, P Manseta, K Sultan, E Zhou, L Pourrezaei, K Najafizadeh, L Gandjbakhche, A Daryoush, AS AF Khwaja, A. M. Daruwalla, P. Manseta, K. Sultan, E. Zhou, L. Pourrezaei, K. Najafizadeh, L. Gandjbakhche, A. Daryoush, A. S. GP IEEE TI UWB Wireless Link Design and Implementation Challenges in Broadband Frequency Modulated fNIR Biomedical Imaging SO 2011 IEEE RADIO AND WIRELESS SYMPOSIUM (RWS) SE IEEE Radio and Wireless Symposium LA English DT Proceedings Paper CT IEEE Radio and Wireless Symposium (RWS) CY JAN 16-19, 2011 CL Phoenix, AR SP IEEE, IEEE Commun Soc (ComSoc), IEEE Microwave Theory & Tech Soc (MTT-S), IEEE Antennas & Propagat Soc (APS), IEEE Vehicle Tech Soc (VTS) DE Functional Near Infra Red Imaging (fNIR); Ultra Wide Band Communications; System Architectures; Gilbert Cell Mixer; Fractal Antenna AB Functional spectroscopic measurements of brain matter using near IR wavelengths are characterized by absorption coefficient mu(a) and scattering coefficient mu'(s). To increase the accuracy of parameter extraction, a broadband frequency modulated system is proposed and design and implementation challenges of a completely untethered and field deployable unit and a high speed wireless communication system is considered to complement a free space optical communication system. C1 [Khwaja, A. M.; Daruwalla, P.; Manseta, K.; Sultan, E.; Zhou, L.; Daryoush, A. S.] Drexel Univ, Dept ECE, Philadelphia, PA 19104 USA. [Pourrezaei, K.] Drexel Univ, Sch Biomed Engn & Hlth Syst, Philadelphia, PA 19104 USA. [Najafizadeh, L.; Gandjbakhche, A.] NIH, Bethesda, MD 20892 USA. RP Khwaja, AM (reprint author), Drexel Univ, Dept ECE, Philadelphia, PA 19104 USA. EM daryoush@ece.drexel.edu FU Center for Neuroscience and Regenerative Medicine (CNRM); Intramural Research Program (IRP); National Institute of Child Health and Human Development (NICHD) FX This research is partly supported by the Center for Neuroscience and Regenerative Medicine (CNRM), and the Intramural Research Program (IRP) of Eunice Shriver National Institute of Child Health and Human Development (NICHD) of the National Institutes of Health. We also thank Prathaban Mookiah from Drexel Wireless Systems Laboratory for assisting us with antenna radiation pattern measurement. NR 9 TC 1 Z9 1 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2164-2958 BN 978-1-4244-7685-5 J9 IEEE RADIO WIRELESS PY 2011 BP 394 EP 397 DI 10.1109/RWS.2011.5725495 PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BYM97 UT WOS:000299393600095 ER PT S AU Xia, T Kapoor, A Kazanzides, P Taylor, R AF Xia, Tian Kapoor, Ankur Kazanzides, Peter Taylor, Russell GP IEEE TI A Constrained Optimization Approach to Virtual Fixtures for Multi-Robot Collaborative Teleoperation SO 2011 IEEE/RSJ INTERNATIONAL CONFERENCE ON INTELLIGENT ROBOTS AND SYSTEMS SE IEEE International Conference on Intelligent Robots and Systems LA English DT Proceedings Paper CT IEEE/RSJ International Conference on Intelligent Robots and Systems CY SEP 25-30, 2011 CL San Francisco, CA SP IEEE, Robot Soc Japan (RSJ), BOSCH, HONDA, KUKA, SRI Int, ABB, Willow Garage, ALDEBARAN, Google, INTUITIVE Surg, SCHUNK, IEEE Ind Elect Soc (IES), Soc Instrument & Control Engineers (SICE), New Technol Fdn (NTF), IEEE Robot & Automat Soc (RAS), Inst Control, Robto & Syst (ICROS) AB This paper presents a constrained optimization framework that enables the implementation of multi-robot constraints, as virtual fixtures, to assist human operators, in a teleoperated scenario. The collaborative constraints guide the motion of multiple robots such that the spatial and temporal relationships are maintained between them, while following human input motion objectives. We demonstrate this control architecture for the task of manipulating a surgical knot to a target point. The teleoperation system uses four arms from a da Vinci Surgical System (R) (two master manipulators and two slave manipulators), with custom electronics and software. It extends previous work, which focused on a cooperatively controlled system where the motions of two robots were directly controlled by user-applied forces. Our current system enables us to effectively evaluate the accuracy of the knot positioning task and completion time in a clinically realistic setup for Minimally Invasive Surgery. C1 [Xia, Tian; Kazanzides, Peter; Taylor, Russell] Johns Hopkins Univ, Dept Comp Sci, Lab Computat Sensing & Robot, Baltimore, MD 21218 USA. [Kapoor, Ankur] Natl Inst Hlth, Bethesda, MD USA. RP Xia, T (reprint author), Johns Hopkins Univ, Dept Comp Sci, Lab Computat Sensing & Robot, Baltimore, MD 21218 USA. EM txial@jhu.edu RI Kazanzides, Peter/A-3358-2010; OI Kazanzides, Peter/0000-0002-6117-5467 FU National Science Foundation Graduate Research Fellowship FX he authors gratefully acknowledge Balazs Vagvolgyi and Jim Gwilliam for assistance with robotic calibration and visualization, and MinYang Jung and Anton Deguet for assistance with network communication and cisst library. The funding of this research was provided by the National Science Foundation Graduate Research Fellowship. NR 11 TC 6 Z9 6 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2153-0858 BN 978-1-61284-455-8 J9 IEEE INT C INT ROBOT PY 2011 BP 639 EP 644 PG 6 WC Computer Science, Artificial Intelligence; Computer Science, Information Systems; Engineering, Electrical & Electronic; Robotics SC Computer Science; Engineering; Robotics GA BXX70 UT WOS:000297477500100 ER PT J AU Cheng, RD Senseney, J Pandya, N McCreedy, E McAuliffe, MJ Bokinsky, A AF Cheng, Ruida Senseney, Justin Pandya, Nishith McCreedy, Evan McAuliffe, Matthew J. Bokinsky, Alexandra BE Soda, P Tortorella, F TI A flexible Java GPU-enhanced visualization framework and its applications SO 2012 25TH INTERNATIONAL SYMPOSIUM ON COMPUTER-BASED MEDICAL SYSTEMS (CBMS) LA English DT Proceedings Paper CT 25th International Symposium on Computer-Based Medical Systems (CBMS) CY JUN 20-22, 2012 CL Univ Campus Bio-Medico Rome, Rome, ITALY SP IEEE, IEEE Comp Soc, Gruppo Italiano Ricercatori Pattern Recognit, EMB, IFIP, Univ degli Studi Cassino Lazio Meridionale HO Univ Campus Bio-Medico Rome AB A flexible biomedical visualization framework implemented with Java, OpenGL, and OpenCL performs efficient volume rendering with large, multi-modal datasets. The,framework takes advantage of the parallel processing power on modern graphics hardware with novel Open CL and GLSL shading language implementations. The Java and GPU environment provide portable advanced biomedical image visualization applications. Several applications built on top of the GPU framework are also presented to show the extensibility of the application. These include multi-surface rendering, stereoscopic rendering, image fusion, and diffusion tensor visualization. C1 [Cheng, Ruida; Senseney, Justin; Pandya, Nishith; McCreedy, Evan; McAuliffe, Matthew J.] Natl Inst Hlth, Imaging Sci Lab, Ctr Informat Technol, Bethesda, MD 20892 USA. [Bokinsky, Alexandra] Geometr Tools Inc, Chapel Hill, NC USA. RP Cheng, RD (reprint author), Natl Inst Hlth, Imaging Sci Lab, Ctr Informat Technol, Bethesda, MD 20892 USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4673-2051-1 PY 2011 PG 6 WC Computer Science, Interdisciplinary Applications; Engineering, Electrical & Electronic; Radiology, Nuclear Medicine & Medical Imaging SC Computer Science; Engineering; Radiology, Nuclear Medicine & Medical Imaging GA BDA86 UT WOS:000312384400010 ER PT J AU Resnik, DB Shamoo, AE AF Resnik, David B. Shamoo, Adil E. TI The Singapore Statement on Research Integrity SO ACCOUNTABILITY IN RESEARCH-POLICIES AND QUALITY ASSURANCE LA English DT Article DE Singapore Statement; research integrity; ethics; international research C1 [Resnik, David B.] NIEHS, NIH, Res Triangle Pk, NC 27709 USA. [Shamoo, Adil E.] Univ Maryland, Sch Med, Baltimore, MD 21201 USA. RP Resnik, DB (reprint author), NIEHS, NIH, Box 12233,MD CU 03, Res Triangle Pk, NC 27709 USA. EM resnikd@niehs.nih.gov FU National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH) FX This research was supported by the National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH). It does not represent the views of the NIEHS, NIH, or U.S. government. NR 7 TC 10 Z9 10 U1 0 U2 0 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0898-9621 J9 ACCOUNT RES JI Account. Res. PY 2011 VL 18 IS 2 BP 71 EP 75 AR PII 934341751 DI 10.1080/08989621.2011.557296 PG 5 WC Medical Ethics SC Medical Ethics GA 733JN UT WOS:000288259100001 PM 21390871 ER PT J AU Resnik, DB AF Resnik, David B. TI Disclosure of Individualized Research Results: A Precautionary Approach SO ACCOUNTABILITY IN RESEARCH-POLICIES AND QUALITY ASSURANCE LA English DT Article DE autonomy; beneficence; disclosing research results; precautionary principle; risk ID CLINICAL-RESEARCH; THERAPEUTIC MISCONCEPTION; PARTICIPATORY RESEARCH; PRINCIPLE; SCIENCES; ETHICS; TRIALS; CANCER; SAFE AB Assessing and managing risks to participants is a central point of contention in the debate about disclosing individualized research results. Those who favor disclosure of only clinically significant results think that disclosing clinically insignificant results is risky and costly, and that harm prevention should take precedence over other ethical considerations. Those who favor giving participants the option of full disclosure regard these risks as insubstantial, and think that obligations to benefit participants and promote their autonomy and right to know outweigh the obligation to prevent harm or financial considerations. The risks of disclosing clinically insignificant research results are currently not quantifiable, due to lack of empirical data. The precautionary principle provides some insight into this debate because it applies to decision-making concerning risks that are plausible but not quantifiable. A precautionary approach would favor full disclosure of individualized results with appropriate safeguards to prevent, minimize, or mitigate risks to participants, such as: validating testing methods; informing participants about their options for receiving tests results and the potential benefits and risks related to receiving results; assessing participants' comfort with handling uncertainty; providing counseling and advice to participants; following-up with individuals who receive tests results; and forming community advisory boards to help investigators deal with issues related to disclosure. C1 NIEHS, NIH, Res Triangle Pk, NC 27709 USA. RP Resnik, DB (reprint author), NIEHS, NIH, Box 12233,Mail Drop CU 03, Res Triangle Pk, NC 27709 USA. EM resnikd@niehs.nih.gov FU Intramural NIH HHS [ZIA ES102646-04, ZIA ES102646-03] NR 51 TC 3 Z9 3 U1 2 U2 4 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0898-9621 J9 ACCOUNT RES JI Account. Res. PY 2011 VL 18 IS 6 BP 382 EP 397 DI 10.1080/08989621.2011.622172 PG 16 WC Medical Ethics SC Medical Ethics GA 856NE UT WOS:000297648300002 PM 22011068 ER PT J AU Tang, J Maddali, K Dreis, CD Sham, YY Vince, R Pommier, Y Wang, ZQ AF Tang, Jing Maddali, Kasthuraiah Dreis, Christine D. Sham, Yuk Y. Vince, Robert Pommier, Yves Wang, Zhengqiang TI N-3 Hydroxylation of Pyrimidine-2,4-diones Yields Dual Inhibitors of HIV Reverse Transcriptase and Integrase SO ACS MEDICINAL CHEMISTRY LETTERS LA English DT Article DE HIV; integrase; reverse transcriptase; dual inhibitor; rational design ID IMMUNODEFICIENCY-VIRUS TYPE-1; DESIGNED MULTIPLE LIGANDS; NONNUCLEOSIDE INHIBITORS; ANTI-HIV-1 ACTIVITY; IN-VITRO; ANALOGS; POTENT; RESISTANCE; DISCOVERY; EMIVIRINE AB A new molecular scaffold featuring an N-hydroxyimide functionality and capable of inhibiting both reverse transcriptase (RT) and integrase (IN) of human immunodeficiency virus (HIV) was rationally designed based on 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) non-nucleoside RT inhibitors (NNRTIs). The design involves a minimal 3-N hydroxylation of the pyrimidine ring of HEPT compound to yield a chelating triad which, along with the existing benzyl group, appeared to satisfy major structural requirements for IN binding. In the mean time, this chemical modification did not severely compromise the compound's ability to inhibit RT. A preliminary structure-activity relationship (SAR) study reveals that this N-3 OH is essential for IN inhibition and that the benzyl group on N-1 side chain is more important for IN binding than the one on C-6. C1 [Tang, Jing; Dreis, Christine D.; Sham, Yuk Y.; Vince, Robert; Wang, Zhengqiang] Univ Minnesota, Ctr Drug Design, Acad Hlth Ctr, Minneapolis, MN 55455 USA. [Maddali, Kasthuraiah; Pommier, Yves] NCI, Mol Pharmacol Lab, NIH, Bethesda, MD 20892 USA. RP Wang, ZQ (reprint author), Univ Minnesota, Ctr Drug Design, Acad Hlth Ctr, 516 Delaware St SE, Minneapolis, MN 55455 USA. EM wangx472@umn.edu RI Sham, Yuk/A-6472-2011 FU Center for Drug Design at the University of Minnesota; Center for Cancer Research, National Cancer Institute; IATAP; NIH FX This research was supported by the Center for Drug Design at the University of Minnesota, the Center for Cancer Research, National Cancer Institute and an IATAP grant to Y.P., NIH. NR 27 TC 30 Z9 33 U1 0 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1948-5875 J9 ACS MED CHEM LETT JI ACS Med. Chem. Lett. PD JAN PY 2011 VL 2 IS 1 BP 63 EP 67 DI 10.1021/ml1002162 PG 5 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 707SL UT WOS:000286306200013 PM 21499541 ER PT J AU Gage, JC Ghosh, A Borgonovo, S Follansbee, S Wentzensen, N Gravitt, PE Grabe, N Lahrmann, B Castle, PE AF Gage, Julia C. Ghosh, Arpita Borgonovo, Sylvia Follansbee, Stephen Wentzensen, Nicolas Gravitt, Patti E. Grabe, Niels Lahrmann, Bernd Castle, Philip E. TI A Comparison of Dacron versus Flocked Nylon Swabs for Anal Cytology Specimen Collection SO ACTA CYTOLOGICA LA English DT Article DE Cytology; Anal neoplasia; Human papillomavirus testing; Screening; Cytological techniques ID HUMAN-PAPILLOMAVIRUS; INTRAEPITHELIAL NEOPLASIA; PCR; MEN; SAMPLES; LESIONS AB Objectives: We compared the performance of commonly used Dacron versus flocked nylon swabs for anal cytology. Study Design: From 23 HIV-positive men screened at Kaiser Permanente San Francisco (San Francisco, Calif., USA), 2 anal specimens were collected, 1 with each swab in random order, and placed into liquid cytology medium. Specimens were tested for cellularity by quantifying a genomic DNA (erv-3). The number of cells was assessed from prepared slides by automated image analysis. Performance was compared between swabs using 2-sample t tests and standard crossover trial analysis methods accounting for period effect. Results: Flocked swabs collected slightly more erv-3 cells than Dacron for the first sample although not significantly (p = 0.18) and a similar number of erv-3 cells for the second sample (p = 0.85). Flocked swabs collected slightly more cells per slide than the Dacron swabs at both time periods although this was only significant in the second time period (p = 0.42 and 0.03 for first and second periods, respectively). In crossover trial analysis, flocked swabs outperformed Dacron for cell count per slide based on slide imaging (p = 0.03), but Dacron and flocked swabs performed similarly based on erv-3 quantification (p = 0.14). Conclusions: Further studies should determine whether flocked swabs increase the representation of diagnostically important cells compared to Dacron. Copyright (C) 2011 S. Karger AG, Basel C1 [Gage, Julia C.] NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, NIH,DHHS,EPS, Rockville, MD 20852 USA. [Borgonovo, Sylvia; Follansbee, Stephen] Kaiser Permanente San Francisco, Dept Med, Div Infect Dis, San Francisco, CA USA. [Gravitt, Patti E.] Johns Hopkins Univ, Dept Epidemiol, Baltimore, MD USA. [Gravitt, Patti E.] Johns Hopkins Univ, Dept Mol Microbiol & Immunol, Baltimore, MD USA. [Castle, Philip E.] Amer Soc Clin Pathologists, Washington, DC USA. [Grabe, Niels; Lahrmann, Bernd] Univ Heidelberg Hosp, Inst Med Biometry & Informat, Sect Med Informat, Heidelberg, Germany. [Grabe, Niels; Lahrmann, Bernd] Hamamatsu Tissue Imaging & Anal Ctr, Heidelberg, Germany. RP Gage, JC (reprint author), NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, NIH,DHHS,EPS, 6120 Execut Blvd,MSC 7231, Rockville, MD 20852 USA. EM gagej@mail.nih.gov NR 13 TC 11 Z9 11 U1 0 U2 5 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0001-5547 J9 ACTA CYTOL JI Acta Cytol. PY 2011 VL 55 IS 4 BP 364 EP 367 DI 10.1159/000329488 PG 4 WC Pathology SC Pathology GA 801OE UT WOS:000293448700010 PM 21791907 ER PT J AU Stewart, DM Ramanathan, R Mahanty, S Fedorko, DP Janik, JE Morris, JC AF Stewart, Donn M. Ramanathan, Roshan Mahanty, Siddhartha Fedorko, Daniel P. Janik, John E. Morris, John C. TI Disseminated Strongyloides stercoralis Infection in HTLV-1-Associated Adult T-Cell Leukemia/Lymphoma SO ACTA HAEMATOLOGICA LA English DT Article DE Adult T-cell leukemia; Alemtuzumab; Corticosteroid; Disseminated Strongyloides; HTLV-1; Human T-cell lymphotropic virus type-1 ID EOSINOPHIL COUNT; DIAGNOSIS; HTLV-1; IVERMECTIN; THIABENDAZOLE; ALBENDAZOLE; EXPANSION; RESPONSES; CARRIERS; ANTIGEN AB A 55-year-old woman with human T-cell lymphotropic virus type-1 (HTLV-1)-associated adult T-cell leukemia (ATL) and a history of previously treated Strongyloides stercoralis infection received anti-CD52 monoclonal antibody therapy with alemtuzumab on a clinical trial. After an initial response, she developed ocular involvement by ATL. Alemtuzumab was stopped and high-dose corticosteroid therapy was started to palliate her ocular symptoms. Ten days later, the patient developed diarrhea, vomiting, fever, cough, skin rash, and a deteriorating mental status. She was diagnosed with disseminated S. stercoralis. Corticosteroids were discontinued and the patient received anthelmintic therapy with ivermectin and albendazole with complete clinical recovery. Copyright (C) 2011 S. Karger AG, Basel C1 [Stewart, Donn M.] NCI, Metab Branch, Ctr Canc Res, Mark O Hatfield Clin Res Ctr, Bethesda, MD 20892 USA. [Ramanathan, Roshan; Mahanty, Siddhartha] NIAID, Parasit Dis Lab, Bethesda, MD 20892 USA. [Fedorko, Daniel P.] NIH, Microbiol Serv, Warren G Magnuson Clin Ctr, Bethesda, MD 20892 USA. RP Stewart, DM (reprint author), NCI, Metab Branch, Ctr Canc Res, Mark O Hatfield Clin Res Ctr, Room 4-5330,10 Ctr Dr, Bethesda, MD 20892 USA. EM stewardo@mail.nih.gov OI Mahanty, Siddhartha/0000-0003-1068-0524 FU Center for Cancer Research, National Cancer Institute; National Institute of Allergy and Infectious Diseases, National Institutes of Health FX This study was supported in part by the Intramural Research Program of the Center for Cancer Research, National Cancer Institute, and the National Institute of Allergy and Infectious Diseases, National Institutes of Health. NR 33 TC 12 Z9 12 U1 0 U2 2 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0001-5792 J9 ACTA HAEMATOL-BASEL JI Acta Haematol. PY 2011 VL 126 IS 2 BP 63 EP 67 DI 10.1159/000324799 PG 5 WC Hematology SC Hematology GA 782WW UT WOS:000292044400001 PM 21474923 ER PT S AU Gunzerath, L Hewitt, BG Li, TK Warren, KR AF Gunzerath, Lorraine Hewitt, Brenda G. Li, Ting-Kai Warren, Kenneth R. BE Uhl, GR TI Alcohol research: past, present, and future SO ADDICTION REVIEWS SE Annals of the New York Academy of Sciences LA English DT Article; Book Chapter DE alcohol abuse; alcohol addiction; alcohol dependence; alcohol-use disorders; alcoholism ID COMMUNITY-REINFORCEMENT APPROACH; MANDATED COLLEGE-STUDENTS; COGNITIVE-BEHAVIORAL TREATMENTS; NATIONAL EPIDEMIOLOGIC SURVEY; EMPIRICALLY DERIVED TYPOLOGY; EVENT-RELATED OSCILLATIONS; SUBSTANCE USE DISORDERS; SPECTRUM DISORDERS; UNITED-STATES; RECEPTOR GENE AB Created forty years ago, the National Institute on Alcohol Abuse and Alcoholism (NIAAA) has played a major role in the great strides made in the understanding, treatment, prevention, and public acceptance of alcohol-use disorders. Throughout most of U.S. history "habitual drunkenness" was viewed as a problem of moral degeneracy or character flaw inherent in the individual. However, the wealth of scientific evidence amassed throughout NIAAA's history has established alcoholism as a medical condition, that is, as a disease for which affected individuals should feel no shame or be treated with disdain. We look at the developments in alcohol epidemiology, typology, etiology, prevention, and treatment research over the past 40 years. We also discuss how NIAAA addresses alcohol disorders from a life-course framework, affecting all stages of the lifespan, from fetus through child, adolescent, and young adult, to midlife/senior adult, with each stage involving different risks, consequences, prevention efforts, and treatment strategies. C1 [Gunzerath, Lorraine; Hewitt, Brenda G.; Warren, Kenneth R.] NIAAA, NIH, Rockville, MD 20892 USA. [Li, Ting-Kai] Duke Univ, Med Ctr, Dept Psychiat, Durham, NC 27710 USA. RP Gunzerath, L (reprint author), NIAAA, NIH, 5635 Fishers Lane, Rockville, MD 20892 USA. EM Lg72x@nih.gov NR 209 TC 15 Z9 17 U1 7 U2 22 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA SN 0077-8923 BN 978-1-57331-812-9 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PY 2011 VL 1216 BP 1 EP 23 DI 10.1111/j.1749-6632.2010.05832.x PG 23 WC Substance Abuse; Multidisciplinary Sciences SC Substance Abuse; Science & Technology - Other Topics GA BTN80 UT WOS:000287434400001 PM 21182533 ER PT S AU Hommer, DW Bjork, JM Gilman, JM AF Hommer, Daniel W. Bjork, James M. Gilman, Jodi M. BE Uhl, GR TI Imaging brain response to reward in addictive disorders SO ADDICTION REVIEWS SE Annals of the New York Academy of Sciences LA English DT Article; Book Chapter DE imaging; addiction; alcohol ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; ENVIRONMENTAL RISK-FACTORS; EVENT-RELATED FMRI; CONDUCT DISORDER; SUBSTANCE USE; BEHAVIORAL-INHIBITION; ALCOHOL DEPENDENCE; NUCLEUS-ACCUMBENS; DOPAMINE RELEASE; DETOXIFIED ALCOHOLICS AB We compare the evidence from human neuroimaging studies for and against two of the major hypotheses of how alterations in the brain's reward system underlie addiction. One of these, the impulsivity hypothesis, proposes that addiction is characterized by excessive sensitivity to reward combined with a failure of inhibition. The other, the reward-deficiency hypothesis, proposes that addicted individuals have a reduced response to nondrug rewards that leads them to seek drugs in preference to more socially acceptable goals. Positron emission tomographic (PET) studies of dopamine receptor density and dopamine release strongly support the reward-deficiency hypothesis, while the more recent and numerous functional magnetic resonance imaging (fMRI) studies of goal-directed behavior provide both support and contradiction for each of the hypotheses. Differences in the time scale on which PET and fMRI make measurements probably account for differences in results, at least in part. It is likely that aspects of brain function described by both the impulsivity and reward-deficiency hypotheses contribute to the pathophysiology of addiction. C1 [Hommer, Daniel W.] NIAAA, Lab Clin & Translat Studies, NIH, Bethesda, MD 20892 USA. [Bjork, James M.] Natl Inst Drug Abuse, Clin Neurosci Branch, Div Clin Neurosci & Behav Res, NIH, Bethesda, MD USA. RP Hommer, DW (reprint author), NIAAA, Lab Clin & Translat Studies, NIH, Bethesda, MD 20892 USA. EM danh@mail.nih.gov OI Bjork, James/0000-0003-0593-3291 NR 82 TC 72 Z9 73 U1 1 U2 17 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA SN 0077-8923 BN 978-1-57331-812-9 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PY 2011 VL 1216 BP 50 EP 61 DI 10.1111/j.1749-6632.2010.05898.x PG 12 WC Substance Abuse; Multidisciplinary Sciences SC Substance Abuse; Science & Technology - Other Topics GA BTN80 UT WOS:000287434400004 PM 21272010 ER PT S AU Eiden, LE Weihe, E AF Eiden, Lee E. Weihe, Eberhard BE Uhl, GR TI VMAT2: a dynamic regulator of brain monoaminergic neuronal function interacting with drugs of abuse SO ADDICTION REVIEWS SE Annals of the New York Academy of Sciences LA English DT Article; Book Chapter DE VMAT2; amphetamine; cocaine; addiction; monoamines; vesicular transporter ID VESICULAR AMINE TRANSPORTER; HETEROZYGOTE KNOCKOUT MICE; DOPAMINE TRANSPORTER; NEUROTRANSMITTER TRANSPORTERS; STRIATAL DOPAMINE; NERVOUS-SYSTEM; VESICULAR-MONOAMINE-TRANSPORTER-1 GENE; ACETYLCHOLINE TRANSPORTER; METHAMPHETAMINE USERS; ENDOCRINE-CELLS AB The monoaminergic neuron, in particular the dopaminergic neuron, is central to mediating the hedonic and addictive properties of drugs of abuse. The effects of amphetamine (AMPH) and cocaine (COC), for example, depend on the ability to increase dopamine in the synapse, by effects on either the plasma membrane transporter DAT or the vesicular transporter for monoamine storage, VMAT2. The potential role of DAT as a target for AMPH and COG has been reviewed extensively. Here, we present VMAT2 as a target that enables the rewarding and addictive actions of these drugs, based on imaging, neurochemical, biochemical, cell biological, genetic, and immunohistochemical evidence. The presence of VMAT2 in noradrenergic, serotoninergic, histaminergic, and potentially trace aminergic neurons invites consideration of a wider role for aminergic neurotransmission in AMPH and COC abuse and addiction. C1 [Eiden, Lee E.] NIMH, Mol Neurosci Sect, Lab Cellular & Mol Regulat, NIH, Bethesda, MD 20892 USA. [Weihe, Eberhard] Univ Marburg, Inst Anat & Cell Biol, Marburg, Germany. RP Eiden, LE (reprint author), Bldg 49,Room 5A-38,9000 Rockville Pike, Bethesda, MD 20892 USA. EM eidenl@mail.nih.gov OI Eiden, Lee/0000-0001-7524-944X FU Intramural NIH HHS [ZIA MH002386-28, Z01 MH002386-21, Z01 MH002386-22, Z99 MH999999, ZIA MH002386-23, ZIA MH002386-24, ZIA MH002386-25, ZIA MH002386-26, ZIA MH002386-27] NR 91 TC 39 Z9 41 U1 2 U2 17 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA SN 0077-8923 BN 978-1-57331-812-9 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PY 2011 VL 1216 BP 86 EP + DI 10.1111/j.1749-6632.2010.05906.x PG 4 WC Substance Abuse; Multidisciplinary Sciences SC Substance Abuse; Science & Technology - Other Topics GA BTN80 UT WOS:000287434400007 PM 21272013 ER PT J AU Marshall, MM Kirk, GD Caporaso, NE McCormack, MC Merlo, CA Hague, JC Mehta, SH Engels, EA AF Marshall, Mariah M. Kirk, Gregory D. Caporaso, Neil E. McCormack, Meredith C. Merlo, Christian A. Hague, John C. Mehta, Shruti H. Engels, Eric A. TI Tobacco use and nicotine dependence among HIV-infected and uninfected injection drug users SO ADDICTIVE BEHAVIORS LA English DT Article DE Injection drug use; HIV infection; Smoking; Nicotine dependence; Tobacco ID FAGERSTROM TOLERANCE QUESTIONNAIRE; IMMUNODEFICIENCY-VIRUS-INFECTION; NUTRITION EXAMINATION SURVEY; 3RD NATIONAL-HEALTH; LUNG-CANCER; ANTIRETROVIRAL THERAPY; SMOKING-CESSATION; CIGARETTE-SMOKING; UNITED-STATES; RISK AB Introduction Urban U S populations are burdened by intersecting epidemics of HIV infection injection drug use and cigarette smoking Given the substantial morbidity attributable to tobacco in these populations we characterized smoking behaviors nicotine addiction and tobacco exposure among HIV-infected and HIV uninfected injection drug users (IDUs) in Baltimore Maryland Methods Smoking behaviors among participants in the ALIVE Study were assessed using interviewer administered questionnaires Smoking history and nicotine dependence (Fagerstrom Index scores) were compared by HIV and drug injecting status Serum cotinine (a nicotine metabolite) was measured for a sample of participants by enzyme immunoassay Results Among 1052 participants (29 7% HIV-infected 39 8% active injectors) 85 2% were current smokers and 9 3% were former smokers Smoking prevalence age at smoking initiation and cumulative tobacco exposure were similar by HIV status Median Fagerstrom scores of 4 for HIV infected and HIV uninfected smokers indicated moderate nicotine dependence Daily cigarette consumption was identical by HIV status (median 10 cigarettes) although HIV infected participants were less likely to smoke 1+ pack daily compared to HIV-uninfected participants (18 0% vs 26 9% p = 0 001) Compared to former injectors active injectors had higher smoking prevalence (90 5% vs 81 7% p = 0 0001) greater daily cigarette consumption (30 7% vs 19 6% smoked 1+ pack daily p = 0 0001) and slightly higher Fagerstrom scores (median 5 vs 4) Cotinine levels paralleled self reported cigarette consumption Discussion Tobacco use is extremely common among inner-city IDUs Smoking behavior and nicotine dependence did not materially differ by HIV status but were associated with active drug injection Cessation efforts should target the dual dependence of cigarettes and drugs experienced among this population (C) 2010 Elsevier Ltd All rights reserved C1 [Marshall, Mariah M.; Kirk, Gregory D.; McCormack, Meredith C.; Hague, John C.; Mehta, Shruti H.] Johns Hopkins Univ, Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA. [Kirk, Gregory D.; McCormack, Meredith C.; Merlo, Christian A.; Engels, Eric A.] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA. [Caporaso, Neil E.; Engels, Eric A.] NCI, Div Canc Epidemiol & Genet, NIH, Rockville, MD USA. RP Marshall, MM (reprint author), Johns Hopkins Univ, Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA. FU NIH [R01HL090483, R01DA04334, R01DAl2568]; National Cancer Institute FX Funding for this study was provided by NIH grants R01HL090483 R01DA04334 and R01DAl2568 and by the Intramural Research Program of the National Cancer Institute NR 44 TC 34 Z9 34 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0306-4603 EI 1873-6327 J9 ADDICT BEHAV JI Addict. Behav. PD JAN-FEB PY 2011 VL 36 IS 1-2 BP 61 EP 67 DI 10.1016/j.addbeh.2010.08.022 PG 7 WC Psychology, Clinical; Substance Abuse SC Psychology; Substance Abuse GA 694VK UT WOS:000285326900009 PM 20875704 ER PT B AU Mazaki-Tovi, S Kusanovic, JP Vaisbuch, E Romero, R AF Mazaki-Tovi, Shali Kusanovic, Juan Pedro Vaisbuch, Edi Romero, Roberto BE Preedy, VR Hunter, RJ TI Resistin in Amniotic Fluid SO ADIPOKINES SE Modern Insights into Disease from Molecules to Man LA English DT Article; Book Chapter ID SERUM ADIPONECTIN MULTIMERS; TUMOR-NECROSIS-FACTOR; INSULIN-RESISTANCE; NORMAL-PREGNANCY; PRETERM LABOR; ADIPOSE-TISSUE; COMPLICATED PREGNANCIES; INTRAAMNIOTIC INFECTION; INFLAMMATION; ASSOCIATION AB Resistin, a novel adipocytokine, has been implicated in the regulation of the innate immune response. Specifically, resistin has pro-inflammatory properties that are abrogated by NF-kappa B inhibitor, indicating the importance of NF-kappa B signaling pathway for resistin-induced inflammation. Consistent with this view, circulating plasma resistin concentrations are increased in patients with sepsis, and it has been proposed that plasma concentrations of this adipocytokine can serve as a marker of sepsis severity. Resistin has also been detected in several body fluids, including saliva, urine and synovial fluid. Indeed, resistin accumulates in the inflamed joints of patients with rheumatoid arthritis and its synovial concentrations correlate with other markers of inflammation. Recently, resistin was found to be a physiological constituent of amniotic fluid. In addition, high amniotic fluid resistin concentrations are associated with intra-amniotic infection and/or inflammation, and amniotic fluid resistin concentrations are associated with well-established indices of intra-amniotic inflammation such as amniotic fluid interleukin (IL) 6 concentration and white blood cell count, as well as with amniocentesis-to-delivery interval. The strong association with intra-amniotic infection/inflammation has been corroborated in an unbiased, high-throughput proteomics analysis of amniotic fluid. The aim of this chapter is to present the available evidence regarding amniotic fluid resistin and to discuss their importance and possible implications. C1 [Mazaki-Tovi, Shali; Kusanovic, Juan Pedro; Vaisbuch, Edi; Romero, Roberto] Wayne State Univ, Dept Obstet & Gynecol, Perinatol Res Branch, Intramural Div,NICHD NIH DHHS,Hutzel Womens Hosp, Detroit, MI 48201 USA. RP Romero, R (reprint author), Wayne State Univ, Dept Obstet & Gynecol, Perinatol Res Branch, Intramural Div,NICHD NIH DHHS,Hutzel Womens Hosp, 3990 John R, Detroit, MI 48201 USA. NR 33 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-7988-7; 978-1-57808-689-4 J9 MOD INSIGHTS DIS MOL JI Mod. Insights Dis. Mol. Man PY 2011 BP 404 EP 418 PG 15 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA BC2ZE UT WOS:000351460700037 ER PT J AU Krueger, F Grafman, J AF Krueger, Frank Grafman, Jordan BE Wolf, LE Schreiber, HE Wasserstein, J TI Disorders of Mathematics Implications for Adult Functioning SO ADULT LEARNING DISORDERS: CONTEMPORARY ISSUES SE Neuropsychologists Handbook LA English DT Article; Book Chapter ID LOW-BIRTH-WEIGHT; OF-PROCESSING DIFFERENCES; COTTON-TOP TAMARINS; FRAGILE-X-SYNDROME; DEVELOPMENTAL DYSCALCULIA; LEARNING-DISABILITIES; MENTAL CALCULATION; COGNITIVE NEUROPSYCHOLOGY; CORTICAL ACTIVATION; BRAIN POTENTIALS C1 [Krueger, Frank; Grafman, Jordan] Natl Inst Neurol Disorders & Stroke, Bethesda, MD USA. RP Krueger, F (reprint author), Natl Inst Neurol Disorders & Stroke, Bethesda, MD USA. NR 207 TC 0 Z9 0 U1 3 U2 3 PU TAYLOR & FRANCIS LTD PI LONDON PA 11 NEW FETTER LANE, LONDON EC4P 4EE, ENGLAND BN 978-1-84169-419-1 J9 NEUROPSYCHOLOGIST HB PY 2011 BP 191 EP 218 PG 28 WC Behavioral Sciences; Education, Special; Psychology, Developmental; Neurosciences; Psychology SC Behavioral Sciences; Education & Educational Research; Psychology; Neurosciences & Neurology GA BUQ06 UT WOS:000290022300009 ER PT J AU Amornphimoltham, P Masedunskas, A Weigert, R AF Amornphimoltham, Panomwat Masedunskas, Andrius Weigert, Roberto TI Intravital microscopy as a tool to study drug delivery in preclinical studies SO ADVANCED DRUG DELIVERY REVIEWS LA English DT Review DE Intravital microscopy; Non-linear microscopy; Drug delivery; Cancer ID RAMAN SCATTERING MICROSCOPY; DORSAL SKINFOLD CHAMBER; CELLS IN-VIVO; 2-PHOTON MICROSCOPY; MULTIPHOTON MICROSCOPY; FLUORESCENCE MICROSCOPY; DENDRITIC CELLS; QUANTUM DOTS; LYMPH-NODES; 2ND-HARMONIC GENERATION AB The technical developments in the field of non-linear microscopy have made intravital microscopy one of the most successful techniques for studying physiological and pathological processes in live animals. Intravital microscopy has been utilized to address many biological questions in basic research and is now a fundamental tool for preclinical studies, with an enormous potential for clinical applications. The ability to dynamically image cellular and subcellular structures combined with the possibility to perform longitudinal studies have empowered investigators to use this discipline to study the mechanisms of action of therapeutic agents and assess the efficacy on their targets in vivo. The goal of this review is to provide a general overview of the recent advances in intravital microscopy and to discuss some of its applications in preclinical studies. Published by Elsevier B.V. C1 [Amornphimoltham, Panomwat; Masedunskas, Andrius; Weigert, Roberto] Natl Inst Dent & Craniofacial Res, Intracellular Membrane Trafficking Unit, Oral & Pharyngeal Canc Branch, NIH, Bethesda, MD 20892 USA. RP Weigert, R (reprint author), Natl Inst Dent & Craniofacial Res, Intracellular Membrane Trafficking Unit, Oral & Pharyngeal Canc Branch, NIH, 30 Convent Dr,Room 303A, Bethesda, MD 20892 USA. EM weigertr@mail.nih.gov OI Masedunskas, Andrius/0000-0002-4533-5467 FU NIH, National Institute of Dental and Craniofacial Research. (NIDCR) FX This research was supported by the Intramural Research Program of the NIH, National Institute of Dental and Craniofacial Research. (NIDCR) We apologize to those whose work could not be cited due to space limitations. NR 163 TC 25 Z9 27 U1 2 U2 25 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-409X J9 ADV DRUG DELIVER REV JI Adv. Drug Deliv. Rev. PD JAN-FEB PY 2011 VL 63 IS 1-2 BP 119 EP 128 DI 10.1016/j.addr.2010.09.009 PG 10 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 760WC UT WOS:000290353900008 PM 20933026 ER PT S AU Shears, SB Gokhale, NA Wang, HC Zaremba, A AF Shears, Stephen B. Gokhale, Nikhil A. Wang, Huanchen Zaremba, Angelika BE Cocco, L Weber, G Weber, CEF TI Diphosphoinositol polyphosphates: What are the mechanisms? SO ADVANCES IN ENZYME REGULATION, VOL 51 SE Advances in Enzyme Regulation LA English DT Proceedings Paper CT 51st International Symposium on Regulations of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues CY OCT 04-05, 2010 CL Univ Bologna, Bologna, ITALY HO Univ Bologna ID INOSITOL HEXAKISPHOSPHATE KINASE; ACTIVATED PROTEIN-KINASE; PLECKSTRIN HOMOLOGY DOMAINS; HYPEROSMOTIC STRESS; SACCHAROMYCES-CEREVISIAE; CELL-DEATH; GENE-EXPRESSION; HEAT-SHOCK; PYROPHOSPHATES; TETRAKISPHOSPHATE C1 [Shears, Stephen B.; Gokhale, Nikhil A.; Wang, Huanchen; Zaremba, Angelika] NIEHS, Inositol Signaling Grp, Lab Signal Transduct, NIH,DHHS, Res Triangle Pk, NC 27709 USA. RP Shears, SB (reprint author), NIEHS, Inositol Signaling Grp, Lab Signal Transduct, NIH,DHHS, POB 12233, Res Triangle Pk, NC 27709 USA. EM Shears@niehs.nih.gov FU Intramural NIH HHS [ZIA ES080046-24] NR 91 TC 18 Z9 19 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0065-2571 J9 ADV ENZYME REGUL JI Adv. Enzym. Regul. PY 2011 VL 51 BP 13 EP 25 DI 10.1016/j.advenzreg.2010.09.008 PG 13 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA BWE12 UT WOS:000293715300002 PM 21035493 ER PT B AU Shamir, L AF Shamir, Lior BA Zhang, YJ BF Zhang, YJ TI Pose and Illumination Invariance with Compound Image Transforms SO ADVANCES IN FACE IMAGE ANALYSIS: TECHNIQUES AND TECHNOLOGIES LA English DT Article; Book Chapter ID FACE-RECOGNITION; EIGENFACES AB While current face recognition algorithms have provided convincing performance on frontal face poses, recognition is far less effective when the pose and illumination conditions vary. Here the authors show how compound image transforms can be used for face recognition in various poses and illumination conditions. The method works by first dividing each image into four equal-sized tiles. Then, image features are extracted from the face images, transforms of the images, and transforms of transforms of the images. Finally, each image feature is assigned with a Fisher score, and test images are classified by using a simple Weighted Nearest Neighbor rule such that the Fisher scores are used as weights. Experimental results using the full color FERET dataset show that with no parameter tuning, the accuracy of rank-10 recognition for frontal, quarter-profile, and half-profile images is similar to 98%, similar to 94% and similar to 91%, respectively. The proposed method also achieves perfect accuracy on several other face recognition datasets such as Yale B, ORL and JAFFE. An important feature of this method is that the recognition accuracy improves as the number of subjects in the dataset gets larger. C1 [Shamir, Lior] NIA, NIH, Bethesda, MD 20892 USA. RP Shamir, L (reprint author), NIA, NIH, Bethesda, MD 20892 USA. NR 47 TC 1 Z9 1 U1 0 U2 0 PU IGI GLOBAL PI HERSEY PA 701 E CHOCOLATE AVE, STE 200, HERSEY, PA 17033-1240 USA BN 978-1-61520-992-7; 978-1-61520-991-0 PY 2011 BP 301 EP 315 DI 10.4018/978-1-61520-991-0.ch016 D2 10.4018/978-1-61520-991-0 PG 15 WC Computer Science, Artificial Intelligence SC Computer Science GA BD7PA UT WOS:000363412500017 ER PT S AU Shevach, EM AF Shevach, Ethan M. BE Rudensky, A Sakaguchi, S TI Biological Functions of Regulatory T Cells SO ADVANCES IN IMMUNOLOGY: REGULATORY T-CELLS, VOL 112 SE Advances in Immunology LA English DT Review; Book Chapter ID EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; CENTRAL-NERVOUS-SYSTEM; DENDRITIC CELLS; TGF-BETA; IN-VIVO; CUTTING EDGE; IMMUNE-RESPONSES; LYMPH-NODE; CD4(+)CD25(+); INDUCTION AB The subpopulation of CD4(+) T lymphocytes that co-express the transcription factor Foxp3 plays a unique role as regulatory T lymphocytes (Tregs) that modulate many aspects of the immune response. Multiple mechanisms have been proposed for the suppressor function of CD4(+)Foxp3(+) T cells based on in vitro studies, but much less is known about how Tregs suppress immune responses in vivo. Both polyclonal Tregs and antigen-specific Tregs are capable of exerting potent suppressive effects in vivo, and it is likely that they mediate their biologic functions using different mechanisms. Antigen-specific Tregs primarily target dendritic cells and inhibit dendritic cell functions including the expression of costimulatory molecules and the presentation of antigen early during the generation of the immune response. The end result is a complete inhibition of both the expansion and the differentiation of T effector cells. Polyclonal Tregs also act on dendritic cells, but at a later phase, and do not inhibit expansion of T effector cells, but appear to modulate differentiation and cell trafficking. The cell surface molecules involved in the interaction of Tregs with dendritic cells, as well as the biochemical pathways modified by this interaction remain to be fully elucidated. A complete understand of the biological functions of Tregs in vivo should facilitate the development of pharmacologic and biologic agents that can be used to modulate Treg function in a therapeutic setting. C1 NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA. RP Shevach, EM (reprint author), NIAID, Immunol Lab, NIH, Bldg 10, Bethesda, MD 20892 USA. FU Intramural NIH HHS NR 71 TC 69 Z9 71 U1 3 U2 10 PU ELSEVIER ACADEMIC PRESS INC PI SAN DIEGO PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA SN 0065-2776 BN 978-0-12-387827-4 J9 ADV IMMUNOL JI Adv.Immunol. PY 2011 VL 112 BP 137 EP 176 DI 10.1016/B978-0-12-387827-4.00004-8 PG 40 WC Immunology SC Immunology GA BYN00 UT WOS:000299395600004 PM 22118408 ER PT S AU Liu, ZG AF Liu, Zhenggang BE Wallach, D Kovalenko, A Feldman, M TI ATIA, A MULTI-TASK PROTEIN THAT PROTECTS CELLS AGAINST TNF-INDUCED APOPTOSIS SO ADVANCES IN TNF FAMILY RESEARCH SE Advances in Experimental Medicine and Biology LA English DT Meeting Abstract CT 12th Biennial International TNF Conference CY APR, 2009 CL San Lorenzo del Escorial, SPAIN C1 [Liu, Zhenggang] NCI, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0065-2598 BN 978-1-4419-6611-7 J9 ADV EXP MED BIOL JI Adv.Exp.Med.Biol. PY 2011 VL 691 BP 736 EP 737 PG 2 WC Biochemistry & Molecular Biology; Biology; Immunology; Medicine, Research & Experimental SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Immunology; Research & Experimental Medicine GA BVG74 UT WOS:000291501300186 ER PT J AU Royall, J Lyon, B AF Royall, J. Lyon, B. TI Sea-Change or Change Challenge? Health Information access in Developing Countries: The US National Library of Medicine experience SO AFRICAN HEALTH SCIENCES LA English DT Article AB Health professionals in developing countries want access to information to help them make changes in health care and contribute to medical research. However, they face challenges of technology limitations, lack of training, and, on the village level, culture and language. This report focuses on the U. S. National Library of Medicine experience with access: for the international medical/scientific community to health information which has been published by researchers in developing countries; for scientists and clinicians in developing countries to their own literature and to that of their colleagues around the world; for medical librarians who are a critical conduit for students, faculty, researchers, and, increasingly, the general public; and for the front line workers at the health center in the village at the end of the line. The fundamental question of whether or not information communication technology can make a difference in access and subsequently in health is illustrated by an anecdote regarding an early intervention in Africa in 1992. From that point, we examine programs to improve access involving malaria researchers, medical journal editors, librarians, and medical students working with local health center staff in the village. Although access is a reality, the positive change in health that the information technology intervention might produce often remains a mirage. Information and technology are not static elements in the equation for better access. They must function together, creating a dialectic in which they transform and inform one another and those whom their combination touches. African Health Sciences 2011; 11(3): 457 - 463 C1 [Royall, J.; Lyon, B.] NIH, Natl Lib Med, Bethesda, MD 20894 USA. RP Royall, J (reprint author), NIH, Natl Lib Med, 8600 Rockville Pike Bldg 38,Room 2S-22, Bethesda, MD 20894 USA. EM jroyall@nlm.nih.gov NR 7 TC 6 Z9 6 U1 0 U2 7 PU MAKERERE UNIV, FAC MED PI KAMPALA PA PO BOX 7072, KAMPALA, 00000, UGANDA SN 1680-6905 J9 AFR HEALTH SCI JI Afr. Health Sci. PY 2011 VL 11 IS 3 BP 457 EP 463 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 970ZN UT WOS:000306171400026 PM 22275940 ER PT J AU Kamrava, M Gius, D Casagrande, G Kohn, E AF Kamrava, Mitchell Gius, David Casagrande, Giovanna Kohn, Elise TI Will targeting insulin growth factor help us or hurt us?: An oncologist's perspective SO AGEING RESEARCH REVIEWS LA English DT Review DE Insulin growth factor; Cancer; Aging ID FACTOR-I RECEPTOR; IGF-BINDING PROTEIN-3; LIFE-SPAN EXTENSION; CELL-CELL ADHESION; BREAST-CANCER CELLS; CAENORHABDITIS-ELEGANS; DWARF MICE; CALORIE RESTRICTION; EXTENDED LONGEVITY; FACTOR (IGF)-I AB The insulin/insulin growth factor (IGF) pathway is a critical mediator of longevity and aging. Efforts to extend longevity by altering the insulin/IGF pathway may have varying effects on other physiological processes. Reduced insulin/IGF levels may decrease the incidence of certain cancers as well as the risk of developing metastatic disease. However, it may also increase the risk of developing cardiovascular disease as well as cardiovascular related mortality. Pursuing the right insulin/IGF pathway targets will require striking a balance between inhibiting cancer cell development and progression and avoiding damage to tissues under normal insulin/IGF-mediated control. This review will discuss the roles of the insulin/IGF pathway in aging and longevity and the development of cancer cell metastasis and considerations in taking insulin/IGF directed targets to the oncology clinic. Published by Elsevier Ireland Ltd. C1 [Casagrande, Giovanna; Kohn, Elise] NCI, Med Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA. [Kamrava, Mitchell; Gius, David] NCI, Mol Radiat Oncol Sect, Radiat Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA. RP Kohn, E (reprint author), NCI, Med Oncol Branch, Ctr Canc Res, 10 Ctr Dr,MSC 1906, Bethesda, MD 20892 USA. EM kohne@mail.nih.gov FU NIH, National Cancer Institute, Center for Cancer Research FX This research was supported by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research. NR 99 TC 4 Z9 4 U1 0 U2 1 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 1568-1637 J9 AGEING RES REV JI Ageing Res. Rev. PD JAN PY 2011 VL 10 IS 1 SI SI BP 62 EP 70 DI 10.1016/j.arr.2009.10.007 PG 9 WC Cell Biology; Geriatrics & Gerontology SC Cell Biology; Geriatrics & Gerontology GA 717SY UT WOS:000287068900007 PM 19896561 ER PT J AU Horikawa, I Fujita, K Harris, CC AF Horikawa, Izumi Fujita, Kaori Harris, Curtis C. TI p53 governs telomere regulation feedback too, via TRF2 SO AGING-US LA English DT Article DE telomere uncapping; p53; ubiquitin ligase; TRF2; feedback regulation ID CELLULAR SENESCENCE; DNA-DAMAGE; STEM-CELLS; REPLICATIVE SENESCENCE; HUMAN-CHROMOSOMES; MUTANT P53; ATM; OVERHANG; PATHWAY; CANCER AB p53 takes critical part in a number of positive and negative feedback loops to regulate carcinogenesis, aging and other biological processes. Uncapped or dysfunctional telomeres are an endogenous DNA damage that activates ATM kinase (ataxia telangiectasia mutated) and then p53 to induce cellular senescence or apoptosis. Our recent study shows that p53, a downstream effector of the telomere damage signaling, also functions upstream of the telomere-capping protein complex by inhibiting one of its components, TRF2 (telomeric repeat binding factor 2). Since TRF2 inhibition leads to ATM activation, a novel positive feedback loop exists to amplify uncapped telomere-induced, p53-mediated cellular responses. Siah1 (seven in absentia homolog 1), a p53-inducible E3 ubiquitin ligase, plays a key role in this feedback regulation by targeting TRF2 for ubiquitination and proteasomal degradation. Biological significance and therapeutic implications of this study are discussed. C1 [Horikawa, Izumi; Fujita, Kaori; Harris, Curtis C.] NCI, Human Carcinogenesis Lab, NIH, Bethesda, MD 20892 USA. RP Harris, CC (reprint author), NCI, Human Carcinogenesis Lab, NIH, Bldg 37, Bethesda, MD 20892 USA. EM Curtis_Harris@nih.gov NR 49 TC 24 Z9 25 U1 0 U2 4 PU IMPACT JOURNALS LLC PI ALBANY PA 6211 TIPTON HOUSE, STE 6, ALBANY, NY 12203 USA SN 1945-4589 J9 AGING-US JI Aging-US PD JAN PY 2011 VL 3 IS 1 BP 26 EP 32 PG 7 WC Cell Biology SC Cell Biology GA 722FS UT WOS:000287417900010 PM 21266744 ER PT J AU Newman, AB Glynn, NW Taylor, CA Sebastiani, P Perls, TT Mayeux, R Christensen, K Zmuda, JM Barral, S Lee, JH Simonsick, EM Walston, JD Yashin, AI Hadley, E AF Newman, Anne B. Glynn, Nancy W. Taylor, Christopher A. Sebastiani, Paola Perls, Thomas T. Mayeux, Richard Christensen, Kaare Zmuda, Joseph M. Barral, Sandra Lee, Joseph H. Simonsick, Eleanor M. Walston, Jeremy D. Yashin, Anatoli I. Hadley, Evan TI Health and function of participants in the Long Life Family Study: A comparison with other cohorts SO AGING-US LA English DT Article DE longevity; exceptional survival; family studies; genetics; healthy aging; genome wide association study; multicenter studies; aging phenotypes ID CARDIOVASCULAR-DISEASE; PULMONARY-FUNCTION; LIVED PARENTS; HEART-DISEASE; MORTALITY; AGE; FRAMINGHAM; DISABILITY; LONGEVITY; CENTENARIANS AB Individuals from families recruited for the Long Life Family Study (LLFS) (n=4559) were examined and compared to individuals from other cohorts to determine whether the recruitment targeting longevity resulted in a cohort of individuals with better health and function. Other cohorts with similar data included the Cardiovascular Health Study, the Framingham Heart Study, and the New England Centenarian Study. Diabetes, chronic pulmonary disease and peripheral artery disease tended to be less common in LLFS probands and offspring compared to similar aged persons in the other cohorts. Pulse pressure and triglycerides were lower, high density lipids were higher, and a perceptual speed task and gait speed were better in LLFS. Age-specific comparisons showed differences that would be consistent with a higher peak, later onset of decline or slower rate of change across age in LLFS participants. These findings suggest several priority phenotypes for inclusion in future genetic analysis to identify loci contributing to exceptional survival. C1 [Newman, Anne B.; Glynn, Nancy W.; Taylor, Christopher A.; Zmuda, Joseph M.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Ctr Aging & Populat Hlth, Pittsburgh, PA 15213 USA. [Newman, Anne B.] Univ Pittsburgh, Sch Med, Div Geriatr Med, Pittsburgh, PA 15261 USA. [Sebastiani, Paola] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA. [Perls, Thomas T.] Boston Univ, Med Ctr, Dept Med, Div Geriatr, Boston, MA 02118 USA. [Mayeux, Richard; Barral, Sandra; Lee, Joseph H.] Columbia Univ, Gertrude H Sergievsky Ctr, New York, NY 10032 USA. [Mayeux, Richard; Barral, Sandra; Lee, Joseph H.] Columbia Univ, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10032 USA. [Christensen, Kaare] Univ So Denmark, Danish Aging Res Ctr, Odense, Denmark. [Simonsick, Eleanor M.; Hadley, Evan] NIA, NIH, Bethesda, MD 20892 USA. [Walston, Jeremy D.] Johns Hopkins Med Inst, Bayview Med Ctr, Baltimore, MD 21224 USA. [Yashin, Anatoli I.] Duke Univ, Ctr Demog Studies, Durham, NC 27708 USA. RP Newman, AB (reprint author), Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Ctr Aging & Populat Hlth, Pittsburgh, PA 15213 USA. EM newmana@edc.pitt.edu RI Christensen, Kaare/C-2360-2009; Lee, Joseph/D-2441-2012; Newman, Anne/C-6408-2013; OI Christensen, Kaare/0000-0002-5429-5292; Lee, Joseph/0000-0002-2000-4821; Newman, Anne/0000-0002-0106-1150; sebastiani, paola/0000-0001-6419-1545; Glynn, Nancy/0000-0003-2265-0162 FU National Institute on Aging (NIA) [U01-AG023712, U01-AG23744, U01-AG023746, U01-AG023749, U01-AG023755, AG-023629, R01 AG-15928, R01 AG-20098, AG-027058, 5K24AG025727]; National Heart, Lung, and Blood Institute [N01-HC-85079, N01-HC-85086, N01-HC-35129, N01 HC-15103, N01 HC-55222, N01-HC-75150, N01-HC-45133, U01 HL080295, R01 HL-075366]; University of Pittsburgh Claude; NHLBI; FHS FX LLFS : Sponsored by the National Institute on Aging (NIA cooperative agreements U01-AG023712, U01-AG23744, U01-AG023746, U01-AG023749 and U01-AG023755). CHS: The research reported in this article was supported by the National Institute on Aging AG-023629. CHS was supported by contract numbers N01-HC-85079 through N01-HC-85086, N01-HC-35129, N01 HC-15103, N01 HC-55222, N01-HC-75150, N01-HC-45133, grant number U01 HL080295 from the National Heart, Lung, and Blood Institute, with additional contribution from the National Institute of Neurological Disorders and Stroke. Additional support was provided through R01 AG-15928, R01 AG-20098, and AG-027058 from the National Institute on Aging, R01 HL-075366 from the National Heart, Lung and Blood Institute, and the University of Pittsburgh Claude. D. Pepper Older Americans Independence Center P30-AG-024827. A full list of principal CHS investigators and institutions can be found at http://www.chs-nhlbi.org/pi.htm. FHS: The Framingham Heart Study is conducted and supported by the NHLBI in collaboration with the FHS Investigators. This manuscript was prepared using limited access datasets obtained from the NHLBI and does not necessarily reflect the opinions or views of the FHS or the NHLBI. NECS: This research was supported by the National Institute on Aging (NIA) 5K24AG025727, Characterizing Human Exceptional Longevity. NR 32 TC 50 Z9 51 U1 1 U2 4 PU IMPACT JOURNALS LLC PI ALBANY PA 6211 TIPTON HOUSE, STE 6, ALBANY, NY 12203 USA SN 1945-4589 J9 AGING-US JI Aging-US PD JAN PY 2011 VL 3 IS 1 BP 63 EP 76 PG 14 WC Cell Biology SC Cell Biology GA 722FS UT WOS:000287417900014 PM 21258136 ER PT J AU Imamichi, H DeGray, G Asmuth, DM Fischl, MA Landay, AL Lederman, MM Sereti, I AF Imamichi, Hiromi DeGray, Gerald Asmuth, David M. Fischl, Margaret A. Landay, Alan L. Lederman, Michael M. Sereti, Irini TI HIV-1 viruses detected during episodic blips following interleukin-7 administration are similar to the viruses present before and after interleukin-7 therapy SO AIDS LA English DT Article DE HIV-1; interleukin-7; quasispecies; transient HIV viremia; virus reservoir ID IL-7; TYPE-1; EXPRESSION; MACAQUES AB Background: Administration of recombinant human interleukin (IL)-7 leads to CD4 and CD8 T-cell expansions in HIV-infected individuals, demonstrating promising capacity for immune reconstitution. However, a proportion of patients treated with recombinant human IL-7 experience transient increases in plasma HIV-RNA ('blips'), possibly reflecting 'purging' of a quiescent reservoir that provides a barrier to viral eradication. Objective: To identify the sources of HIV detected during transient viremic episodes following IL-7 administration, viral quasispecies were analyzed in a total of 281 primary sequences derived from seven patients who experienced the episodic blips following IL-7 therapy. Method: The C2-V3 regions of the HIV-1 env gene were sequenced from HIV-1 RNA in plasma and HIV DNA from peripheral blood mononuclear cells (PBMCs) obtained at baseline (day 0 of recombinant human IL-7 therapy), during the episode of viral blips (day 4), and at a time when levels of plasma HIV-RNA had returned to less than 50 copies/ml (day 28). Results: The HIV sequences detected during transient viremia following IL-7 administration were closely related to those of the plasma viruses present before and after cytokine administration. All virus quasispecies detected during blips were also present in proviral sequences in PBMCs. Conclusion: The low level viremia induced by IL-7 likely reflects predominantly transient induction or release of virus from a preexisting pool rather than activation of silent quasispecies. (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins C1 [Imamichi, Hiromi; Sereti, Irini] NIAID, Clin & Mol Retrovirol Sect, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA. [DeGray, Gerald] NCI, Lab Mol Retrovirol, Clin Serv Program, SAIC Frederick Inc, Frederick, MD USA. [Asmuth, David M.] Univ Calif, Davis Med Ctr, Sacramento, CA USA. [Fischl, Margaret A.] Univ Miami, Miller Sch Med, Miami, FL 33136 USA. [Landay, Alan L.] Rush Univ, Med Ctr, Chicago, IL 60612 USA. [Lederman, Michael M.] Case Western Reserve Univ, Univ Hosp, Case Med Ctr, Cleveland, OH 44106 USA. RP Imamichi, H (reprint author), NIAID, Clin & Mol Retrovirol Sect, Immunoregulat Lab, NIH, Bldg 550,Room 201-A,POB B, Frederick, MD 21702 USA. EM himamichi@nih.gov FU National Institute of Allergy and Infectious Diseases; Individual AIDS Clinical Trials Units at Case Western Reserve University [AI 25879]; Rush University [AI 68636]; Northwestern University [AI 25915]; University of California; Davis Medical Center [AI 38858]; University of Miami [AI 27675]; Cytheris; National Cancer Institute, National Institutes of Health [HHSN261200800001E]; National institute of Allergy and infectious Disease (NIAID), National Institutes of Health [HHSN261200800001E]; NIAID FX The present study was supported in part by the AIDS Clinical Trials Group funded by the National Institute of Allergy and Infectious Diseases and the individual AIDS Clinical Trials Units at Case Western Reserve University (AI 25879), Rush University (AI 68636), Northwestern University (AI 25915), University of California, Davis Medical Center (AI 38858), and University of Miami (AI 27675). This work was also supported in part by the Intramural Research Program of the National Institutes of Health, National Institute of Allergy and Infectious Diseases. The authors thank all study participants and the ACTG5214 study team.; M.M.L. has received research support from Cytheris. All other authors have declared no conflict of interest.; This project has been funded in part by federal funds from the National Cancer Institute, National Institutes of Health, under contract HHSN261200800001E, the National institute of Allergy and infectious Disease (NIAID), National Institutes of Health, under contract HHSN261200800001E and by the Intramural Research Program of NIAID. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government. NR 14 TC 26 Z9 27 U1 2 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0269-9370 J9 AIDS JI Aids PD JAN PY 2011 VL 25 IS 2 BP 159 EP 164 DI 10.1097/QAD.0b013e328340a270 PG 6 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 697GT UT WOS:000285501900005 PM 21124203 ER PT J AU Booth, RE Campbell, BK Mikulich-Gilbertson, SK Tillotson, CJ Choi, D Robinson, J Calsyn, DA Mandler, RN Jenkins, LM Thompson, LL Dempsey, CL Liepman, MR McCarty, D AF Booth, Robert E. Campbell, Barbara K. Mikulich-Gilbertson, Susan K. Tillotson, Carrie J. Choi, Dongseok Robinson, James Calsyn, Donald A. Mandler, Raul N. Jenkins, Lindsay M. Thompson, Laetitia L. Dempsey, Catherine L. Liepman, Michael R. McCarty, Dennis TI Reducing HIV-Related Risk Behaviors Among Injection Drug Users in Residential Detoxification SO AIDS AND BEHAVIOR LA English DT Article DE Drug injection; Risk reduction; Treatment entry; Detoxification ID OUT-OF-TREATMENT; HUMAN-IMMUNODEFICIENCY-VIRUS; GENDER-DIFFERENCES; HEPATITIS-C; METHADONE-MAINTENANCE; ABUSE TREATMENT; OUTPATIENT TREATMENT; AIDS-PREVENTION; TREATMENT ENTRY; SAN-FRANCISCO AB This study of 632 drug injectors enrolled in eight residential detoxification centers within the National Drug Abuse Treatment Clinical Trials Network tested three interventions to reduce drug and sex risk behaviors. Participants were randomized to: (a) a two-session, HIV/HCV counseling and education (C&E) model added to treatment as usual (TAU), (b) a one-session, therapeutic alliance (TA) intervention conducted by outpatient counselors to facilitate treatment entry plus TAU, or (c) TAU. Significant reductions in drug and sex risk behaviors occurred for all three conditions over a 6-month follow-up period. C&E participants reported significantly greater rates of attending an HIV testing appointment, but this was not associated with better risk reduction outcomes. Reporting treatment participation within 2 months after detoxification and self-efficacy to practice safer injection behavior predicted reductions in injection risk behaviors. Findings indicate that participation in detoxification was followed by significant decreases in drug injection and risk behaviors for up to 6-months; interventions added to standard treatment offered no improvement in risk behavior outcomes. C1 [Campbell, Barbara K.; Choi, Dongseok; McCarty, Dennis] Oregon Hlth & Sci Univ, Dept Publ Hlth & Prevent Med, Portland, OR 97239 USA. [Booth, Robert E.; Mikulich-Gilbertson, Susan K.; Thompson, Laetitia L.; Dempsey, Catherine L.] Univ Colorado, Dept Psychiat, Denver, CO 80202 USA. [Tillotson, Carrie J.] Oregon Hlth & Sci Univ, Oregon Clin & Translat Res Inst, Portland, OR 97239 USA. [Robinson, James] Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA. [Calsyn, Donald A.] Univ Washington, Inst Alcohol & Drug Abuse, Seattle, WA 98195 USA. [Calsyn, Donald A.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [Jenkins, Lindsay M.] Recovery Ctr King Cty, Seattle, WA USA. [Mandler, Raul N.] Natl Inst Drug Abuse, Clin Trials Network, Bethesda, MD USA. [Liepman, Michael R.] Michigan State Univ, Kalamazoo Ctr Med Studies, Dept Psychiat, Kalamazoo, MI USA. RP Campbell, BK (reprint author), Oregon Hlth & Sci Univ, Dept Publ Hlth & Prevent Med, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA. EM drbarbaracampbell@earthlink.net FU NCRR NIH HHS [UL1 RR024140]; NIDA NIH HHS [U10 DA013716, U10 DA013036, U10 DA013036-08, U10 DA013710, U10 DA013714, U10 DA015831, U10 DA13036, U10 DA13710, U10 DA13714, U10 DA13716, U10 DA15831] NR 78 TC 13 Z9 13 U1 1 U2 6 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1090-7165 J9 AIDS BEHAV JI AIDS Behav. PD JAN PY 2011 VL 15 IS 1 BP 30 EP 44 DI 10.1007/s10461-010-9751-7 PG 15 WC Public, Environmental & Occupational Health; Social Sciences, Biomedical SC Public, Environmental & Occupational Health; Biomedical Social Sciences GA 708TM UT WOS:000286387200005 PM 20652630 ER PT J AU Chan, YF Passetti, LL Garner, BR Lloyd, JJ Dennis, ML AF Chan, Ya-Fen Passetti, Lora L. Garner, Bryan R. Lloyd, Jacqueline J. Dennis, Michael L. TI HIV Risk Behaviors: Risky Sexual Activities and Needle Use Among Adolescents in Substance Abuse Treatment SO AIDS AND BEHAVIOR LA English DT Article DE HIV risk; Sexual risk; Adolescent; Substance use; Mental health ID PSYCHIATRIC-DISORDERS; PSYCHOLOGICAL DISTRESS; GENDER-DIFFERENCES; DELINQUENT YOUTH; UNITED-STATES; YOUNG-ADULTS; INFECTION; DRUGS; COMORBIDITY; PREVALENCE AB This study estimated prevalence of HIV risk behaviors and its association with substance use and mental health problems among adolescents in treatment. A pooled dataset of 9,519 adolescents admitted to substance abuse treatment programs between 2002 and 2006 was analyzed. HIV risk behaviors, substance use, and mental health problems were assessed at treatment intake. Sixty percent of adolescents were engaged in at least one sexual or needle use risk behavior in the year prior to entering treatment. Sex with multiple partners, sex under the influence of alcohol or drugs, and unprotected sex were the most prevalent HIV risk behaviors. Several gender differences were found for specific types of sexual and needle use behaviors. Adolescents with substance dependence or other comorbid mental health problems were at increased odds for HIV risk. Findings suggest treatment programs may benefit adolescents better by screening them consistently for HIV risk behaviors and incorporating tailored interventions. C1 [Chan, Ya-Fen; Passetti, Lora L.; Garner, Bryan R.; Dennis, Michael L.] Chestnut Hlth Syst, ML Dennis Lighthouse Inst, Normal, IL 61761 USA. [Lloyd, Jacqueline J.] Natl Inst Drug Abuse, NIH, Bethesda, MD USA. RP Chan, YF (reprint author), Chestnut Hlth Syst, ML Dennis Lighthouse Inst, 448 Wylie Dr, Normal, IL 61761 USA. EM ychan@chestnut.org FU CSAT SAMHSA HHS [TI13322, TI13344, TI14103, TI14189, TI14196, TI14271, TI14376, TI15348, TI15421, TI15447, TI15458, TI15461, TI15467, TI15469, TI15478, TI15481, TI15483, TI15485, TI15489, TI15511, TI15524, TI15562, TI15577, TI15584, TI15586, TI15670, TI15672, TI15674, TI15678, TI16400, TI16949, TI16961, TI16992, TI1705, TI17070, TI17119, TI17434, TI18406, TI3345, TI11894, TI13340, TI17530, TI17484, TI17475, TI17446, TI17433, TI17334, TI17095, TI17071, TI17046, TI17002, TI16991, TI16984, TI16939, TI16935, TI16928, TI16915, TI16904, TI16418, TI16414, TI16386, TI15686, TI15682, TI15677, TI15671, TI15545, TI15527, TI15514, TI15486, TI15479, TI15475, TI15466, TI15446, TI15433, TI15415, TI15413, TI14355, TI14315, TI14311, TI14283, TI14272, TI14267, TI14261, TI14254, TI14252, TI14214, TI14188, TI14090, TI13356, TI13354, TI13323, TI13309, TI13305, TI11888, TI11871, TI11433, TI11424, TI11422, TI11323, TI11321, TI11892, TI11874, TI11432, TI11423, TI11324, TI11320, TI11317, TI13308, TI13313]; NIDA NIH HHS [R37 DA011323] NR 47 TC 13 Z9 13 U1 2 U2 6 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1090-7165 J9 AIDS BEHAV JI AIDS behav. PD JAN PY 2011 VL 15 IS 1 BP 114 EP 124 DI 10.1007/s10461-010-9702-3 PG 11 WC Public, Environmental & Occupational Health; Social Sciences, Biomedical SC Public, Environmental & Occupational Health; Biomedical Social Sciences GA 708TM UT WOS:000286387200013 PM 20411413 ER PT J AU Nakigozi, G Makumbi, F Reynolds, S Galiwango, R Kagaayi, J Nalugoda, F Ssettuba, A Sekasanvu, J Musuuza, J Serwada, D Gray, R Wawer, M AF Nakigozi, Gertrude Makumbi, Fredrick Reynolds, Steven Galiwango, Ronald Kagaayi, Joseph Nalugoda, Fred Ssettuba, Absalom Sekasanvu, Joseph Musuuza, Jackson Serwada, David Gray, Ron Wawer, Maria TI Non-enrollment for free community HIV care: findings from a population-based study in Rakai, Uganda SO AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV LA English DT Article DE HIV; HIV care; enrollment ID BEHAVIOR AB Improved understanding of HIV-related health-seeking behavior at a population level is important in informing the design of more effective HIV prevention and care strategies. We assessed the frequency and determinants of failure to seek free HIV care in Rakai, Uganda. HIV-positive participants in a community cohort who accepted VCT were referred for free HIV care (cotrimoxazole prophylaxis, CD4 monitoring, treatment of opportunistic infections, and, when indicated, antiretroviral therapy). We estimated proportion and adjusted Prevalence Risk Ratios (adj. PRR) of non-enrollment into care six months after receipt of VCT using log-binomial regression. About 1145 HIV-positive participants in the Rakai Community Cohort Study accepted VCT and were referred for care. However, 31.5% (361/1145) did not enroll into HIV care six months after referral. Non-enrollment was significantly higher among men (38%) compared to women (29%, p = 0.005). Other factors associated with non-enrollment included: younger age (15-24 years, adj. PRR = 2.22; 95% CI: 1.64, 3.00), living alone (adj. PRR = 2.22; 95% CI: 1.57, 3.15); or in households with 1-2 co-residents (adj. PRR = 1.63; 95% CI: 1.31, 2.03) compared to three or more co-residents, or a CD4 count >250 cells/ul (adj. PRR = 1.81; 95% CI: 1.38, 2.46). Median (IQR) CD4 count was lower among enrolled 388 cells/ul (IQR: 211,589) compared to those not enrolled 509 cells/ul (IQR: 321,754). About one-third of HIV-positive persons failed to utilize community-based free services. Non-use of services was greatest among men, the young, persons with higher CD4 counts and the more socially isolated, suggesting a need for targeted strategies to enhance service uptake. C1 [Nakigozi, Gertrude; Galiwango, Ronald; Kagaayi, Joseph; Nalugoda, Fred; Ssettuba, Absalom; Sekasanvu, Joseph; Musuuza, Jackson] Rakai Hlth Sci Program, Kalisizo, Rakai, Uganda. [Makumbi, Fredrick; Serwada, David] Makerere Univ, Sch Publ Hlth, Kampala, Uganda. [Reynolds, Steven] NIAID, NIH, Bethesda, MD 20892 USA. [Gray, Ron; Wawer, Maria] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA. RP Nakigozi, G (reprint author), Rakai Hlth Sci Program, Old Bukoba Rd, Kalisizo, Rakai, Uganda. EM gnakigozi@rhsp.org FU Intramural NIH HHS [Z99 AI999999] NR 16 TC 20 Z9 20 U1 0 U2 0 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0954-0121 J9 AIDS CARE JI Aids Care-Psychol. Socio-Med. Asp. Aids-Hiv PY 2011 VL 23 IS 6 BP 764 EP 770 DI 10.1080/09540121.2010.525614 PG 7 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychology, Multidisciplinary; Respiratory System; Social Sciences, Biomedical SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychology; Respiratory System; Biomedical Social Sciences GA 764FT UT WOS:000290615500015 PM 21293989 ER PT J AU Malee, KM Tassiopoulos, K Huo, YL Siberry, G Williams, PL Hazra, R Smith, RA Allison, SM Garvie, PA Kammerer, B Kapetanovic, S Nichols, S Van Dyke, R Seage, GR Mellins, CA AF Malee, Kathleen M. Tassiopoulos, Katherine Huo, Yanling Siberry, George Williams, Paige L. Hazra, Rohan Smith, Renee A. Allison, Susannah M. Garvie, Patricia A. Kammerer, Betsy Kapetanovic, Suad Nichols, Sharon Van Dyke, Russell Seage, George R., III Mellins, Claude A. CA Pediat HIV AIDS Cohort Study Team TI Mental health functioning among children and adolescents with perinatal HIV infection and perinatal HIV exposure SO AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV LA English DT Article DE mental health problems; children and adolescents; perinatal HIV exposure; HIV infection ID DEPRESSIVE SYMPTOMS; INTELLECTUAL DISABILITY; BEHAVIORAL-PROBLEMS; PSYCHOPATHOLOGY; DISORDERS; MOTHERS; HIV/AIDS; RISK; PREVALENCE; PREDICTORS AB Mental health problems (MHPs) among children with perinatal HIV infection have been described prior to and during the highly active antiretroviral therapy (HAART) era. Yet child, caregiver and socio-demographic factors associated with MHPs are not fully understood. We examined the prevalence of MHPs among older children and adolescents with perinatal HIV exposure, including both perinatally HIV-infected (PHIV+) and perinatally HIV-exposed but uninfected (PHEU) youth. Our aims were to identify the impact of HIV infection by comparing PHIV+ and PHEU youth and to delineate risk factors associated with MHPs, in order to inform development of appropriate prevention and intervention strategies. Youth and their caregivers were interviewed with the Behavior Assessment System for Children, 2nd edition (BASC-2) to estimate rates of at-risk and clinically significant MHPs, including caregiver-reported behavioral problems and youth-reported emotional problems. The prevalence of MHPs at the time of study entry was calculated for the group overall, as well as by HIV status and by demographic, child health, and caregiver characteristics. Logistic regression models were used to identify factors associated with youth MHPs. Among 416 youth enrolled between March 2007 and July 2009 (295 PHIV+, 121 PHEU), the overall prevalence of MHPs at entry was 29% and greater than expected based on recent national surveys of the general population. MHPs were more likely among PHEU than among PHIV+ children (38% versus 25%, p < 0.01). Factors associated with higher odds of MHPs at p < 0.10 included caregiver characteristics (psychiatric disorder, limit-setting problems, health-related functional limitations) and child characteristics (younger age and lower IQ). These findings suggest that PHEU children are at high risk for MHPs, yet current models of care for these youth may not support early diagnosis and treatment. Family-based prevention and intervention programs for HIV affected youth and their caregivers may minimize long-term consequences of MHPs. C1 [Malee, Kathleen M.] Northwestern Univ, Childrens Mem Hosp, Feinberg Sch Med, Chicago, IL 60614 USA. [Tassiopoulos, Katherine; Seage, George R., III] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Huo, Yanling] Harvard Univ, Sch Publ Hlth, Ctr Biostat AIDS Res, Boston, MA 02115 USA. [Siberry, George; Hazra, Rohan] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD USA. [Williams, Paige L.] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. [Smith, Renee A.] Univ Illinois, Dept Pediat, Chicago, IL USA. [Allison, Susannah M.; Kapetanovic, Suad] NIMH, Ctr Mental Hlth Res AIDS, Bethesda, MD 20892 USA. [Garvie, Patricia A.] St Jude Childrens Hosp, Memphis, TN 38105 USA. [Kammerer, Betsy] Childrens Hosp, Dept Psychiat, Boston, MA 02115 USA. [Kammerer, Betsy] Childrens Hosp, Dept Otolaryngol & Commun Disorders, Boston, MA 02115 USA. [Nichols, Sharon] Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA. [Van Dyke, Russell] Tulane Univ, Hlth Sci Ctr, Dept Infect Dis, New Orleans, LA 70118 USA. [Mellins, Claude A.] Columbia Univ, Dept Psychiat & Sociomed Sci, New York, NY USA. RP Malee, KM (reprint author), Northwestern Univ, Childrens Mem Hosp, Feinberg Sch Med, Chicago, IL 60614 USA. EM kmalee@childrensmemorial.org FU NICHD NIH HHS [U01 HD052102-04, U01 HD052102, U01 HD052104, U01 HD052104-01] NR 59 TC 32 Z9 32 U1 4 U2 11 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0954-0121 J9 AIDS CARE JI Aids Care-Psychol. Socio-Med. Asp. Aids-Hiv PY 2011 VL 23 IS 12 BP 1533 EP 1544 DI 10.1080/09540121.2011.575120 PG 12 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychology, Multidisciplinary; Respiratory System; Social Sciences, Biomedical SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychology; Respiratory System; Biomedical Social Sciences GA 881KA UT WOS:000299481400002 PM 21702707 ER PT J AU Larder, BA Revell, A Mican, JM Agan, BK Harris, M Torti, C Izzo, I Metcalf, JA Rivera-Goba, M Marconi, VC Wang, DC Coe, D Gazzard, B Montaner, J Lane, HC AF Larder, Brendan A. Revell, Andrew Mican, JoAnn M. Agan, Brian K. Harris, Marianne Torti, Carlo Izzo, Ilaria Metcalf, Julia A. Rivera-Goba, Migdalia Marconi, Vincent C. Wang, Dechao Coe, Daniel Gazzard, Brian Montaner, Julio Lane, H. Clifford TI Clinical Evaluation of the Potential Utility of Computational Modeling as an HIV Treatment Selection Tool by Physicians with Considerable HIV Experience SO AIDS PATIENT CARE AND STDS LA English DT Article ID PREDICT VIROLOGICAL RESPONSE; SOCIETY-USA PANEL; DRUG-RESISTANCE; ANTIRETROVIRAL TREATMENT; VIRTUAL PHENOTYPE; GENOTYPE; THERAPY; RECOMMENDATIONS; INFECTION; SYSTEMS AB The HIV Resistance Response Database Initiative (RDI), which comprises a small research team in the United Kingdom and collaborating clinical centers in more than 15 countries, has used antiretroviral treatment and response data from thousands of patients around the world to develop computational models that are highly predictive of virologic response. The potential utility of such models as a tool for assisting treatment selection was assessed in two clinical pilot studies: a prospective study in Canada and Italy, which was terminated early because of the availability of new drugs not covered by the system, and a retrospective study in the United States. For these studies, a Web-based user interface was constructed to provide access to the models. Participating physicians entered baseline data for cases of treatment failure and then registered their treatment intention. They then received a report listing the five alternative regimens that the models predicted would be most effective plus their own selection, ranked in order of predicted virologic response. The physicians then entered their final treatment decision. Twenty-three physicians entered 114 cases (75 unique cases with 39 entered twice by different physicians). Overall, 33% of treatment decisions were changed following review of the report. The final treatment decisions and the best of the RDI alternatives were predicted to produce greater virologic responses and involve fewer drugs than the original selections. Most physicians found the system easy to use and understand. All but one indicated they would use the system if it were available, particularly for highly treatment-experienced cases with challenging resistance profiles. Despite limitations, the first clinical evaluation of this approach by physicians with substantial HIV-experience suggests that it has the potential to deliver clinical and economic benefits. C1 [Larder, Brendan A.; Revell, Andrew; Wang, Dechao; Coe, Daniel] HIV Resistance RDI, London, England. [Mican, JoAnn M.; Metcalf, Julia A.; Lane, H. Clifford] NIAID, Bethesda, MD 20892 USA. [Agan, Brian K.; Marconi, Vincent C.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Harris, Marianne; Montaner, Julio] BC Ctr Excellence HIV AIDS, Vancouver, BC, Canada. [Torti, Carlo; Izzo, Ilaria] Univ Brescia, Brescia, Italy. [Rivera-Goba, Migdalia] NIH, Ctr Clin, Bethesda, MD 20892 USA. [Gazzard, Brian] Chelsea & Westminster Hosp, London, England. RP Revell, A (reprint author), RDI, 14 Union Sq, London N1 7DH, England. EM andrewrevell@hivrdi.org RI Marconi, Vincent/N-3210-2014; OI Marconi, Vincent/0000-0001-8409-4689; Agan, Brian/0000-0002-5114-1669 FU National Cancer Institute, National Institutes of Health [HHSN261200800001E]; National Institute of Allergy and Infectious Diseases; Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) [IDCRP-000-15]; National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) [Y1-AI-5072] FX This project has been funded in whole or in part with federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261200800001E. This research was supported in whole or in part by the National Institute of Allergy and Infectious Diseases.; Support for a portion of this work (IDCRP-000-15) was provided by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072. NR 21 TC 15 Z9 15 U1 0 U2 2 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1087-2914 J9 AIDS PATIENT CARE ST JI Aids Patient Care STDS PD JAN PY 2011 VL 25 IS 1 BP 29 EP 36 DI 10.1089/apc.2010.0254 PG 8 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 704PW UT WOS:000286065900005 PM 21214377 ER PT J AU Veronese, F Anton, P Fletcher, CV DeGruttola, V McGowan, I Becker, S Zwerski, S Burns, D AF Veronese, Fulvia Anton, Peter Fletcher, Courtney V. DeGruttola, Victor McGowan, Ian Becker, Stephen Zwerski, Sheryl Burns, David CA Workshop Organizing Comm TI Implications of HIV PrEP Trials Results SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID INFECTION; IDENTIFICATION; PREVENTION AB Six randomized clinical trials have been implemented to examine the efficacy of tenofovir disoproxil fumarate (TDF) and/or TDF/emtricitabine (TDF/FTC) as preexposure prophylaxis for HIV-1 infection (PrEP). Although largely complementary, the six trials have many similar features. As the earliest results become available, an urgent question may arise regarding whether changes should be made in the conduct of the other trials. To consider this in advance, a Consultation on the Implications of HIV Pre-Exposure Prophylaxis (PrEP) Trials Results sponsored by the Division of AIDS (DAIDS) of the National Institute of Allergy and infectious Diseases (NIAID), National Institutes of Health (NTH), and the Bill and Melinda Gates Foundation (BMGF) was held on 'January 29, 2010, at the Natcher Conference Center, NIH, Bethesda, MD. Participants included basic scientists, clinical researchers (including investigators performing the current PrEP trials), and representatives from the U.S. Food and Drug Administration (FDA) and the agencies sponsoring the trials: the U.S. Centers for Disease Control and Prevention (CDC), the U.S. Agency for International Development (USAID), the BMGF, and the U.S. NIH. We report here a summary of the presentations and highlights of salient discussion topics from this workshop. C1 [Veronese, Fulvia; Zwerski, Sheryl; Burns, David] NIAID, PSP, DAIDS, NIH, Bethesda, MD 20892 USA. [Anton, Peter] Univ Calif Los Angeles, Ctr HIV Prevent Res, David Geffen Sch Med, Los Angeles, CA USA. [Fletcher, Courtney V.] Univ Nebraska Med Ctr, Coll Pharm, Omaha, NE USA. [DeGruttola, Victor] Harvard Univ, Harvard Sch Publ Hlth, Boston, MA 02115 USA. [McGowan, Ian] Univ Pittsburgh, Sch Med, Div Gastroenterol Hepatol & Nutr, Magee Womens Res Inst, Pittsburgh, PA USA. [Becker, Stephen] BMGF, Global Hlth HIV, Seattle, WA USA. RP Veronese, F (reprint author), NIAID, PSP, DAIDS, NIH, 5th Floor,Room 5122,6700B Rockledge Dr, Bethesda, MD 20892 USA. EM veronesf@niaid.nih.gov RI Hendrix, Craig/G-4182-2014 OI Hendrix, Craig/0000-0002-5696-8665 FU BMGF; DAIDS; NIAID; NTH; B L Seamon (BLS) Corporation FX The authors wish to thank the BMGF and DAIDS, NIAID, NTH [via its contract for conference planning and support services with B L Seamon (BLS) Corporation] for sponsoring this consultation. The authors also wish to extend their thanks to the organizing committee-Dr. Stephen Becker, BMGF (external member); and Drs. Paul Black, Roberta Black, David Burns, Diana Finzi, Jim Turpin, Fulvia Veronese, and Mrs. Sheryl Zwerski [internal (NIH/NIAID/DAIDS) members]-for their critical contributions in developing the workshop's objectives and agenda. Furthermore, we wish to thank the facilitators of the breakout sessions, Drs. Hoosen Coovadia (University of KwaZulu-Natal) and Veronica Miller (George Washington University), and the rapporteurs, Drs. Victor DeGruttola (Harvard School of Public Health) and Ian McGowan (Magee-Women's Research Institute/University of Pittsburgh School of Medicine) for their outstanding effort in highlighting important issues to consider for the field. Lastly, we wish to thank Ms. Jennifer Coulter and Mrs. Jean Morrow, Henry M. Jackson Foundation (HJF), for their assistance in all aspects of the workshop (in conjunction with BLS), and Mr. Lester Freeman (HJF) for his meticulous editorial assistance and contributions to the workshop. The authors are indeed grateful to all who participated in and supported this workshop in an effort to advance the field. NR 17 TC 11 Z9 13 U1 0 U2 4 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD JAN PY 2011 VL 27 IS 1 BP 81 EP 90 DI 10.1089/aid.2010.0226 PG 10 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 708JL UT WOS:000286358000013 PM 20969483 ER PT J AU Sanders-Beer, BE Spano, YY Golighty, D Lara, A Hebblewaite, D Nieves-Duran, L Rhodes, L Mansfield, KG AF Sanders-Beer, Brigitte E. Spano, Yvette Y. Golighty, Dawn Lara, Abigail Hebblewaite, Diane Nieves-Duran, Lourdes Rhodes, Lowrey Mansfield, Keith G. TI Clinical monitoring and correlates of nephropathy in SIV-infected macaques during high-dose antiretroviral therapy SO AIDS RESEARCH AND THERAPY LA English DT Article AB Background: In many preclinical AIDS research studies, antiretroviral therapy (ART) is administered to experimentally simian immunodeficiency (SIV)-infected rhesus macaques for reduction of viral load to undetectable levels. Prolonged treatment of macaques with a high dose of PMPA (9-[2-(r)-(phosphonomethoxy) propyl] adenine or tenofovir; 30 mg/kg of body weight subcutaneously once daily) can result in proximal renal tubular dysfunction, a Fanconi-like syndrome characterized by glucosuria, aminoaciduria, hypophosphatemia, and bone pathology. In contrast, chronic administration of a low dose of PMPA (10 mg/kg subcutaneously once daily) starting at birth does not seem to be associated with any adverse health effects within 3 years of treatment. In contrast to PMPA, limited information on systemic toxicity in rhesus monkeys is available for FTC (5-fluoro-1-(2R,5S)-[2( hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine; emtricitabine) and stavudine (d4T). Results: In this study, the clinical and biochemical correlates of tubular nephrosis in SIV-infected rhesus macaques associated with systemic administration of high-dose ART consisting of the three nucleoside analog inhibitors PMPA, FTC, and d4T were investigated. It was found that acute renal failure was uncommon (7.1% of treated animals) and that morphologic evidence of nephropathy, which persisted for more than 300 days following discontinuation of the drug cocktail, was more frequent (52.4% of treated animals). While parameters from single time points lacked predictive value, biochemical alterations in Blood Urea Nitrogen (BUN) and phosphorus were frequently identified longitudinally in the blood of ART-treated animals that developed evidence of nephropathy, and these longitudinal changes correlated with disease severity. Conclusions: Recommendations are proposed to limit the impact of drug-induced renal disease in future SIV macaque studies. C1 [Sanders-Beer, Brigitte E.; Golighty, Dawn; Lara, Abigail; Hebblewaite, Diane; Nieves-Duran, Lourdes; Rhodes, Lowrey] So Res Inst, Frederick, MD USA. [Mansfield, Keith G.] Harvard Univ, Sch Med, New England Primate Res Ctr, Southborough, MA 01772 USA. [Sanders-Beer, Brigitte E.] BIOQUAL Inc, Rockville, MD 20850 USA. [Spano, Yvette Y.] NIAID, Vaccine Res Program, Div Aids, NIH, Bethesda, MD 20817 USA. RP Sanders-Beer, BE (reprint author), So Res Inst, Frederick, MD USA. EM bsanders@bioqual.com FU NIH/NIAID [N01-AI-15451] FX This work was supported by NIH/NIAID contract N01-AI-15451. PMPA and FTC were kindly provided by Gilead Corporation, and Zerit (R) was a gift from the AIDS Research and Reference Reagent Program, NIAID, NIH. We would also like to thank Dr. Ron Desrosiers for donating the SIVmac239 challenge stock, and Audra Hachey for tissue processing. NR 21 TC 4 Z9 4 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-6405 J9 AIDS RES THER JI Aids Res. Ther. PY 2011 VL 8 AR 3 DI 10.1186/1742-6405-8-3 PG 11 WC Infectious Diseases SC Infectious Diseases GA V27LK UT WOS:000208614500003 PM 21255437 ER PT J AU Warren, KR Hewitt, BG Thomas, JD AF Warren, Kenneth R. Hewitt, Brenda G. Thomas, Jennifer D. TI Fetal Alcohol Spectrum Disorders Research Challenges and Opportunities SO ALCOHOL RESEARCH & HEALTH LA English DT Article DE Fetal alcohol spectrum disorders; fetal alcohol syndrome; fetal alcohol effects; maternal alcohol consumption; prenatal alcohol exposure; pregnancy; alcohol related birth defects; developmental disorders; diagnosis; research; alcohol-related neurodevelopmental disorder ID ACID ETHYL-ESTERS; PRENATAL ALCOHOL; BRIEF INTERVENTION; BIRTH-DEFECTS; UNITED-STATES; ETHANOL; PREGNANCY; EXPOSURE; PREVALENCE; DIAGNOSIS AB The adverse effects of prenatal alcohol consumption have long been known; however, a formal description and clinical diagnosis of these effects was not introduced until 1973. Since then, the distinction of the wide range of effects that can be induced by prenatal alcohol exposure, and, consequently, the terminology to describe these effects has continued to evolve. Although much progress has been made in understanding the consequences of prenatal alcohol exposure, challenges still remain in properly identifying all affected individuals as well as their individual patterns of alcohol-induced deficits. Also, as the large numbers of women who continue to drink during pregnancy indicate, prevention efforts still require further refinement to enhance their effectiveness. In addition, the mechanisms underlying alcohol-induced damage have not yet been fully elucidated; as knowledge of the mechanisms underlying alcohol-induced deficits continues to grow, the possibility of minimizing potential harm by intervening during prenatal alcohol exposure is enhanced. Finally, researchers are exploring additional ways to improve or fully restore behavioral and cognitive functions disrupted by prenatal alcohol exposure by treating the individuals with fetal alcohol spectrum disorders, thereby reducing the heavy burden for affected individuals and their families. C1 [Warren, Kenneth R.; Hewitt, Brenda G.] NIAAA, Bethesda, MD USA. [Thomas, Jennifer D.] San Diego State Univ, Dept Psychol, Ctr Behav Teratol, San Diego, CA 92182 USA. RP Warren, KR (reprint author), NIAAA, Bethesda, MD USA. FU NIAAA NIH HHS [AA-014811, R01 AA012446, AA-012446, U24 AA014811] NR 41 TC 25 Z9 25 U1 2 U2 9 PU NATL INST ALCOHOL ABUSE ALCOHOLISM PI ROCKVILLE PA 6000 EXECUTIVE BLVD, ROCKVILLE, MD 20892-7003 USA SN 1535-7414 J9 ALCOHOL RES HEALTH JI Alcohol Res. Health PY 2011 VL 34 IS 1 BP 4 EP 14 PG 11 WC Substance Abuse SC Substance Abuse GA 783XJ UT WOS:000292117900001 PM 23580035 ER PT J AU Chen, WJA Maier, SE AF Chen, Wei-Jung A. Maier, Susan E. TI COMBINATION DRUG USE AND RISK FOR FETAL HARM SO ALCOHOL RESEARCH & HEALTH LA English DT Editorial Material ID EPIDEMIOLOGIC ANALYSIS; COOCCURRING ALCOHOL; CONCURRENT USE; COCAINE; EXPOSURE; COCAETHYLENE; DISORDERS; RATS C1 [Chen, Wei-Jung A.] Texas A&M Hlth Sci Ctr, Coll Med, Dept Neurosci & Expt Therapeut, College Stn, TX USA. [Maier, Susan E.] NIAID, Off Initiat Dev, Bethesda, MD 20892 USA. RP Chen, WJA (reprint author), Texas A&M Hlth Sci Ctr, Coll Med, Dept Neurosci & Expt Therapeut, College Stn, TX USA. NR 19 TC 1 Z9 1 U1 0 U2 0 PU NATL INST ALCOHOL ABUSE ALCOHOLISM PI ROCKVILLE PA 6000 EXECUTIVE BLVD, ROCKVILLE, MD 20892-7003 USA SN 1535-7414 J9 ALCOHOL RES HEALTH JI Alcohol Res. Health PY 2011 VL 34 IS 1 BP 27 EP 28 PG 2 WC Substance Abuse SC Substance Abuse GA 783XJ UT WOS:000292117900003 PM 23580037 ER PT J AU Dawson, DA AF Dawson, Deborah A. TI Defining Risk Drinking SO ALCOHOL RESEARCH & HEALTH LA English DT Article DE Alcohol consumption; alcohol use disorder; alcohol-related harm; alcohol and other drug use (AOD) use harm reduction; harm minimization; prevention of harm from AOD use; problematic AOD use; prevention of problematic AOD use; AOD induced risk; attributable risk; risk thresholds; morbidity; AOD risk mortality; AOD risk injury; standard drink; amount of AOD use; responsible AOD use ID ALCOHOL-USE DISORDERS; IDENTIFICATION TEST AUDIT; SINGLE SCREENING QUESTION; ANALYSIS-PROJECT ERCAAP; PRIMARY-CARE VALIDATION; PER-CAPITA CONSUMPTION; US GENERAL-POPULATION; BINGE DRINKING; EMERGENCY-ROOM; CASE-CROSSOVER AB Many efforts to prevent alcohol-related harm are aimed at reducing risk drinking. This article outlines the many conceptual and methodological challenges to defining risk drinking. It summarizes recent evidence regarding associations of various aspects of alcohol consumption with chronic and acute alcohol-related harms, including mortality, morbidity, injury, and alcohol use disorders, and summarizes the study designs most appropriate to defining risk thresholds for these types of harm. In addition, it presents an international overview of low-risk drinking guidelines from more than 20 countries, illustrating the wide range of interpretations of the scientific evidence related to risk drinking. This article also explores the impact of drink size on defining risk drinking and describes variation in what is considered to be a standard drink across populations. Actual and standard drink sizes differ in the United States, and this discrepancy affects definitions of risk drinking and prevention efforts. C1 [Dawson, Deborah A.] NIAAA, Lab Epidemiol & Biometry, NIH, Bethesda, MD USA. FU Intramural NIH HHS NR 119 TC 28 Z9 29 U1 6 U2 17 PU NATL INST ALCOHOL ABUSE ALCOHOLISM PI ROCKVILLE PA 6000 EXECUTIVE BLVD, ROCKVILLE, MD 20892-7003 USA SN 1535-7414 J9 ALCOHOL RES HEALTH JI Alcohol Res. Health PY 2011 VL 34 IS 2 BP 144 EP 156 PG 13 WC Substance Abuse SC Substance Abuse GA 865IM UT WOS:000298304600002 PM 22330212 ER EF