FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Zhao, H Tanegashima, K Ro, H Dawid, IB AF Zhao, Hui Tanegashima, Kosuke Ro, Hyunju Dawid, Igor B. TI Lrig3 regulates neural crest formation in Xenopus by modulating Fgf and Wnt signaling pathways SO DEVELOPMENT LA English DT Article DE Fgf8; MAPK; neural crest; Slug; Wnt3a; Xenopus laevis; leucine-rich repeats protein; animal cap; DNA microarray ID MESODERM INDUCTION; MAP KINASE; NEGATIVE REGULATOR; DISTINCT ELEMENTS; EMBRYOS; EXPRESSION; GENE; RECEPTOR; ACTIVATION; PROTEIN AB Leucine-rich repeats and immunoglobulin-like domains 3 (Lrig3) was identified by microarray analysis among genes that show differential expression during gastrulation in Xenopus laevis. Lrig3 was expressed in the neural plate and neural crest (NC) at neurula stages, and in NC derivatives and other dorsal structures during tailbud stages. A prominent consequence of the morpholino-induced inhibition of Lrig3 expression was impaired NC formation, as revealed by the suppression of marker genes, including Slug, Sox9 and Foxd3. In the NC induction assay involving Chordin plus Wnt3a-injected animal caps, Lrig3 morpholino inhibited expression of Slug, Sox9 and Foxd3, but not of Pax3 and Zic1. In line with this, Lrig3 knockdown prevented NC marker induction by Pax3 and Zic1, suggesting that Lrig3 acts downstream of these two genes in NC formation. Injection of Lrig3 and Wnt3a led to low-level induction of NC markers and enhanced induction of Fgf3, Fgf4 and Fgf8 in animal caps, suggesting a positive role for Lrig3 in Wnt signaling. Lrig3 could attenuate Fgf signaling in animal caps, did interact with Fgf receptor 1 in cultured cells and, according to context, decreased or increased the induction of NC markers by Fgf. We suggest that Lrig3 functions in NC formation in Xenopus by modulating the Wnt and Fgf signaling pathways. C1 [Zhao, Hui; Tanegashima, Kosuke; Ro, Hyunju; Dawid, Igor B.] NICHHD, Mol Genet Lab, NIH, Bethesda, MD 20892 USA. RP Dawid, IB (reprint author), NICHHD, Mol Genet Lab, NIH, Bethesda, MD 20892 USA. EM idawid@nih.gov RI Zhao, Hui/B-8429-2016 FU Intramural NIH HHS [Z01 HD001002-25] NR 78 TC 41 Z9 43 U1 0 U2 4 PU COMPANY OF BIOLOGISTS LTD PI CAMBRIDGE PA BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE CB4 4DL, CAMBS, ENGLAND SN 0950-1991 J9 DEVELOPMENT JI Development PD APR 1 PY 2008 VL 135 IS 7 BP 1283 EP 1293 DI 10.1242/dev.015073 PG 11 WC Developmental Biology SC Developmental Biology GA 287LB UT WOS:000254917500008 PM 18287203 ER PT J AU Lo Iacono, N Mantero, S Chiarelli, A Garcia, E Mills, AA Morasso, MI Costanzo, A Levi, G Guerrini, L Merlo, GR AF Lo Iacono, Nadia Mantero, Stefano Chiarelli, Anna Garcia, Elvin Mills, Alea A. Morasso, Maria I. Costanzo, Antonio Levi, Giovanni Guerrini, Luisa Merlo, Giorgio R. TI Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defects SO DEVELOPMENT LA English DT Article DE Dlx; p63; ectrodactyly; limb development; transcription regulation ID APICAL ECTODERMAL RIDGE; CELL-CYCLE ARREST; SPLIT FOOT LOCUS; TARGET GENES; EPIDERMAL MORPHOGENESIS; DACTYLAPLASIA MOUSE; HOMEOBOX GENES; MICE LACKING; DNA-SEQUENCE; P53 AB The congenital malformation Split Hand-Foot Malformation (SHFM, or ectrodactyly) is characterized by a medial cleft of hands and feet, and missing central fingers. Five genetically distinct forms are known in humans; the most common (type-I) is linked to deletions of DSS1 and the distalless-related homeogenes DLX5 and DLX6. As Dlx5; Dlx6 double-knockout mice show a SHFM-like phenotype, the human orthologs are believed to be the disease genes. SHFM-IV and Ectrodactyly-Ectodermal dysplasia-Cleft lip (EEC) are caused by mutations in p63, an ectoderm-specific p53-related transcription factor. The similarity in the limb phenotype of different forms of SHFM may underlie the existence of a regulatory cascade involving the disease genes. Here, we show that p63 and Dlx proteins colocalize in the nuclei of the apical ectodermal ridge (AER). In homozygous p63(-) (null) and p63(EEC) (R279H) mutant limbs, the AER fails to stratify and the expression of four Dlx genes is strongly reduced; interestingly, the p63(+/EEC) and p63(+/-) hindlimbs, which develop normally and have a normally stratified AER, show reduced Dlx gene expression. The p63(+/EEC) mutation combined with an incomplete loss of Dlx5 and Dlx6 alleles leads to severe limb phenotypes, which are not observed in mice with either mutation alone. In vitro, Delta Np63 alpha induces transcription from the Dlx5 and Dlx6 promoters, an activity abolished by EEC and SHFM-IV mutations, but not by Ankyloblepharon-Ectodermal defects-Cleft lip/palate (AEC) mutations. ChIP analysis shows that p63 is directly associated with the Dlx5 and Dlx6 promoters. Thus, our data strongly implicate p63 and the Dlx5-Dlx6 locus in a pathway relevant in the aetio-pathogenesis of SHFM. C1 [Lo Iacono, Nadia; Chiarelli, Anna; Guerrini, Luisa] Univ Milan, Dept Biomol Sci & Biotechnol, I-20133 Milan, Italy. [Lo Iacono, Nadia; Mantero, Stefano; Merlo, Giorgio R.] Univ Turin, Ctr Mol Biotechnol, Dulbecco Telethon Inst, I-10126 Turin, Italy. [Mantero, Stefano; Merlo, Giorgio R.] CNR, Ist Tecnol Biomed, Milan, Italy. [Garcia, Elvin; Mills, Alea A.] Cold Spring Harbor Lab, New York, NY USA. [Morasso, Maria I.] NIAMS, Dev Skin Biol Unit, NIH, Bethesda, MD USA. [Costanzo, Antonio] Univ Rome, Dept Dermatol, TorVergata, Italy. [Levi, Giovanni] Museum Natl Hist Nat, CNRS, UMR5166, Paris, France. RP Guerrini, L (reprint author), Univ Milan, Dept Biomol Sci & Biotechnol, Via Celoria 26, I-20133 Milan, Italy. EM luisa.guerrini@unimi.it; gmerlo@dti.telethon.it RI Costanzo, Antonio/D-3896-2012; Levi, Giovanni/B-4416-2013; OI Mantero, Stefano/0000-0003-0608-2724; Costanzo, Antonio/0000-0001-9697-2557 FU Telethon [TCP99003] NR 80 TC 55 Z9 56 U1 0 U2 7 PU COMPANY OF BIOLOGISTS LTD PI CAMBRIDGE PA BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE CB4 4DL, CAMBS, ENGLAND SN 0950-1991 J9 DEVELOPMENT JI Development PD APR 1 PY 2008 VL 135 IS 7 BP 1377 EP 1388 DI 10.1242/dev.011759 PG 12 WC Developmental Biology SC Developmental Biology GA 287LB UT WOS:000254917500017 PM 18326838 ER PT J AU Koyama, E Shibukawa, Y Nagayama, M Sugito, H Young, B Yuasa, T Okabe, T Ochiai, T Kamiya, N Rountree, RB Kingsley, DM Iwamoto, M Enomoto-Iwamoto, M Pacifici, M AF Koyama, Eiki Shibukawa, Yoshihiro Nagayama, Motohiko Sugito, Hiroki Young, Blanche Yuasa, Takahito Okabe, Takahiro Ochiai, Takanaga Kamiya, Nobuhiko Rountree, Ryan B. Kingsley, David M. Iwamoto, Masahiro Enomoto-Iwamoto, Motomi Pacifici, Maurizio TI A distinct cohort of progenitor cells participates in synovial Joint and articular cartilage formation during mouse limb skeletogenesis SO DEVELOPMENTAL BIOLOGY LA English DT Article DE synovial joint formation; interzone; limb development; articular cartilage; Gdf5; Wnt9a; signaling pathways ID TRANSCRIPTION FACTOR ERG; SUPERFICIAL ZONE; DOUBLE MUTATIONS; GENE-EXPRESSION; KNEE-JOINT; CHONDROCYTES; OSTEOARTHRITIS; BONE; DIFFERENTIATION; MORPHOGENESIS AB The origin, roles and fate of progenitor cells forming synovial joints during limb skeletogenesis remain largely unclear. Here we produced prenatal and postnatal genetic cell fate-maps by mating ROSA-LacZ-reporter mice with mice expressing Cre-recombinase at prospective joint sites under the control of Gdf5 regulatory sequences (Gdf5-Cre). Reporter-expressing cells initially constituted the interzone, a compact mesenchymal structure representing the first overt sign of joint formation, and displayed a gradient-like distribution along the ventral-to-dorsal axis. The cells expressed genes such as Wnt9a, Erg and collagen IIA, remained predominant in the joint-forming sites over time, gave rise to articular cartilage, synovial lining and other joint tissues, but contributed little if any to underlying growth plate cartilage and shaft. To study their developmental properties more directly, we isolated the joint-forming cells from prospective autopod joint sites using a novel microsurgical procedure and tested them in vitro. The cells displayed a propensity to undergo chondrogenesis that was enhanced by treatment with exogenous rGdf5 but blocked by Wnt9a over-expression. To test roles for such Wnt-mediated anti-chondrogenic capacity in vivo, we created conditional mutants deficient in Wnt/beta-catenin signaling using Co12-Cre or Gdf5-Cre. Synovial joints did form in both mutants; however, the joints displayed a defective flat cell layer normally abutting the synovial cavity and expressed markedly reduced levels of lubricin. In sum, our data indicate that cells present at prospective joint sites and expressing Gdf5 constitute a distinct cohort of progenitor cells responsible for limb joint formation. The cells appear to be patterned along specific limb symmetry axes and rely on local signaling tools to make distinct contributions to joint formation. (C) 2008 Elsevier Inc. All rights reserved. C1 [Koyama, Eiki; Nagayama, Motohiko; Young, Blanche; Yuasa, Takahito; Okabe, Takahiro; Ochiai, Takanaga; Iwamoto, Masahiro; Enomoto-Iwamoto, Motomi; Pacifici, Maurizio] Thomas Jefferson Univ, Coll Med, Dept Orthopaed Surg, Philadelphia, PA 19107 USA. [Shibukawa, Yoshihiro; Sugito, Hiroki] Tokyo Dent Coll, Dept Periodontol, Chiba, Japan. [Kamiya, Nobuhiko] NIES, Mol Dev Biol Grp, Reprod & Dev Toxicol Lab, Res Triangle Pk, NC 27709 USA. [Rountree, Ryan B.; Kingsley, David M.] Stanford Univ, Sch Med, Dept Dev Biol, Stanford, CA 94305 USA. [Rountree, Ryan B.; Kingsley, David M.] Stanford Univ, Sch Med, HHMI, Stanford, CA 94305 USA. RP Enomoto-Iwamoto, M (reprint author), Thomas Jefferson Univ, Coll Med, Dept Orthopaed Surg, Philadelphia, PA 19107 USA. EM motomi.iwamoto@jefferson.edu; maurizio.pacifici@jefferson.edu FU Howard Hughes Medical Institute; NIA NIH HHS [AG025868, R01 AG025868, R01 AG025868-02, R01 AG025868-03]; NIAMS NIH HHS [AR050507, AR042236, AR046000, R01 AR042236, R01 AR046000, R01 AR046000-08, R01 AR046000-09, R01 AR050507, R37 AR042236] NR 52 TC 133 Z9 134 U1 1 U2 11 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0012-1606 J9 DEV BIOL JI Dev. Biol. PD APR 1 PY 2008 VL 316 IS 1 BP 62 EP 73 DI 10.1016/j.ydbio.2008.01.012 PG 12 WC Developmental Biology SC Developmental Biology GA 286KQ UT WOS:000254845200006 PM 18295755 ER PT J AU Covian-Nares, JF Smith, RM Vogel, SS AF Covian-Nares, J. Fernando Smith, Robert M. Vogel, Steven S. TI Two independent forms of endocytosis maintain embryonic cell surface homeostasis during early development SO DEVELOPMENTAL BIOLOGY LA English DT Article DE sea urchin; FM1-43; endocytosis; PAO; agatoxin; src kinase; FK506; Staurosporine; PMA ID SEA-URCHIN EGGS; PROTEIN-KINASE-C; ADRENAL CHROMAFFIN CELLS; SRC FAMILY KINASE; MEMBRANE RETRIEVAL; NERVE-TERMINALS; EXOCYTOSIS; FERTILIZATION; CALCIUM; CYTOKINESIS AB Eukaryotic cells have multiple forms of endocytosis which maintain cell surface homeostasis. One explanation for this apparent redundancy is to allow independent retrieval of surface membranes derived from different types of vesicles. Consistent with this hypothesis we find that sea urchin eggs have at least two types of compensatory endocytosis. One is associated with retrieving cortical vesicle membranes, and formed large endosomes by a mechanism that was inhibited by agatoxin, cadmium, staurosporine and FK506. The second type is thought to compensate for constitutive exocytosis, and formed small endosomes using a mechanism that was insensitive to the above mentioned reagents, but was inhibited by phenylarsine oxide (PAO), and by microinjection of mRNA encoding Src kinase. Both mechanisms could act concurrently, and account for all of the endocytosis occurring during early development. Inhibition of either form did not trigger compensation by the other form, and phorbol ester treatment rescued the endocytotic activity blocked by agatoxin, but not the retrieval blocked by PAO. Published by Elsevier Inc. C1 [Covian-Nares, J. Fernando; Vogel, Steven S.] NIAAA, Lab Mol Physiol, NIH, Bethesda, MD 20892 USA. [Smith, Robert M.] Med Coll Georgia, Dept Med, Inst Mol Med & Genet, Augusta, GA 30912 USA. RP Vogel, SS (reprint author), NIAAA, Lab Mol Physiol, NIH, Bethesda, MD 20892 USA. EM stevevog@mail.nih.gov RI Vogel, Steven/A-3585-2012; OI Vogel, Steven/0000-0002-3005-2667 FU Intramural NIH HHS [Z01 AA000452-05] NR 47 TC 13 Z9 13 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0012-1606 J9 DEV BIOL JI Dev. Biol. PD APR 1 PY 2008 VL 316 IS 1 BP 135 EP 148 DI 10.1016/j.ydbio.2008.01.017 PG 14 WC Developmental Biology SC Developmental Biology GA 286KQ UT WOS:000254845200012 PM 18281031 ER PT J AU Nakano, M Cardinale, S Noskov, VN Gassmann, R Vagnarelli, P Kandels-Lewis, S Larionov, V Earnshaw, WC Masumoto, H AF Nakano, Megumi Cardinale, Stefano Noskov, Vladimir N. Gassmann, Reto Vagnarelli, Paola Kandels-Lewis, Stefanie Larionov, Vladimir Earnshaw, William C. Masumoto, Hiroshi TI Inactivation of a human kinetochore by specific targeting of chromatin modifiers SO DEVELOPMENTAL CELL LA English DT Article ID ZINC-FINGER PROTEINS; ARTIFICIAL CHROMOSOME FORMATION; FUNCTIONAL HUMAN CENTROMERE; FISSION YEAST CENTROMERES; ALPHA-SATELLITE DNA; CENP-A; TRANSCRIPTIONAL REPRESSION; HISTONE DEACETYLATION; ACTIVE GENES; IN-VIVO AB We have used a human artificial chromosome (HAC) to manipulate the epigenetic state of chromatin within an active kinetochore. The HAC has a dimeric alpha-satellite repeat containing one natural monomer with a CENP-B binding site, and one completely artificial synthetic monomer with the CENP-B box replaced by a tetracycline operator (tetO). This HAC exhibits normal kinetochore protein composition and mitotic stability. Targeting of several tet-repressor (tetR) fusions into the centromere had no effect on kinetochore function. However, altering the chromatin state to a more open configuration with the tTA transcriptional activator or to a more closed state with the tTS transcription silencer caused missegregation and loss of the HAC. tTS binding caused the loss of CENP-A, CENP-B, CENP-C, and H3K4me2 from the centromere accompanied by an accumulation of histone H3K9me3. Our results reveal that a dynamic balance between centromeric chromatin and heterochromatin is essential for vertebrate kinetochore activity. C1 [Nakano, Megumi; Noskov, Vladimir N.; Larionov, Vladimir; Masumoto, Hiroshi] NCI, Mol Pharmacol Lab, NIH, Bethesda, MD 20892 USA. [Cardinale, Stefano; Gassmann, Reto; Vagnarelli, Paola; Kandels-Lewis, Stefanie; Earnshaw, William C.] Univ Edinburgh, Welcome Trust Ctr Cell Biol, Edinburgh EH9 3JR, Midlothian, Scotland. RP Larionov, V (reprint author), NCI, Mol Pharmacol Lab, NIH, Bldg 37,Room 5040,9000 Rockville Pike, Bethesda, MD 20892 USA. EM larionov@mail.nih.gov; bill.earnshaw@ed.ac.uk; g44478a@nucc.cc.nagoya-u.ac.jp RI Gassmann, Reto/M-6488-2013; Cardinale, Stefano/F-4024-2014; OI Gassmann, Reto/0000-0002-0360-2977; Cardinale, Stefano/0000-0003-4357-9246 FU Intramural NIH HHS; Wellcome Trust [, 073915] NR 62 TC 130 Z9 132 U1 0 U2 5 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 1534-5807 J9 DEV CELL JI Dev. Cell PD APR PY 2008 VL 14 IS 4 BP 507 EP 522 DI 10.1016/j.devcel.2008.02.001 PG 16 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA 289HR UT WOS:000255046100011 PM 18410728 ER PT J AU Zhu, JJ Nakamura, E Nguyen, MT Bao, XZ Akiyama, H Mackem, S AF Zhu, Jianjian Nakamura, Eiichiro Nguyen, Minh-Thanh Bao, Xiaczhong Akiyama, Haruhiko Mackem, Susan TI Uncoupling sonic hedgehog control of pattern and expansion of the developing limb bud SO DEVELOPMENTAL CELL LA English DT Article ID VERTEBRATE LIMB; MOUSE LIMB; CHOLESTEROL MODIFICATION; CARTILAGE FORMATION; GENE-EXPRESSION; DIGIT IDENTITY; CHICK LIMB; SHH; SKELETON; MICE AB Sonic hedgehog (Shh), which regulates proliferation in many contexts, functions as a limb morphogen to specify a distinct pattern of digits. How Shh's effects on cell number relate to its role in specifying digit identity is unclear. Deleting the mouse Shh gene at different times using a conditional Cre line, we find that Shh functions to control limb development in two phases: a very transient, early patterning phase regulating digit identity, and an extended growth-promoting phase during which the digit precursor mesenchyme expands and becomes recruited into condensing digit primordia. Our analysis reveals an unexpected alternating anterior-posterior sequence of normal mammalian digit formation. The progressive loss of digits upon successively earlier Shh removal mirrors this alternating sequence and highlights Shh's role in cell expansion to produce the normal digit complement. C1 [Zhu, Jianjian; Nakamura, Eiichiro; Nguyen, Minh-Thanh; Bao, Xiaczhong; Mackem, Susan] NCI, Pathol Lab, Bethesda, MD 20892 USA. [Akiyama, Haruhiko] Kyoto Univ, Dept Orthopaed, Kyoto 606, Japan. RP Mackem, S (reprint author), NCI, Pathol Lab, Bethesda, MD 20892 USA. EM mackems@mail.nih.gov NR 37 TC 155 Z9 157 U1 1 U2 14 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 1534-5807 J9 DEV CELL JI Dev. Cell PD APR PY 2008 VL 14 IS 4 BP 624 EP 632 DI 10.1016/j.devcel.2008.01.008 PG 9 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA 289HR UT WOS:000255046100021 PM 18410737 ER PT J AU Varadkar, P Kraman, M Despres, D Ma, G Lozier, J McCright, B AF Varadkar, Prajakta Kraman, Matthew Despres, Daryl Ma, Ge Lozier, Julie McCright, Brent TI Notch2 is required for the proliferation of cardiac neural crest-derived smooth muscle cells SO DEVELOPMENTAL DYNAMICS LA English DT Article DE Notch2; cardiac neural crest; smooth muscle; Notch ID CONGENITAL HEART-DEFECTS; ATRIAL GENE-EXPRESSION; ALAGILLE-SYNDROME; HUMAN JAGGED1; MUTATIONS; MICE; FATE; CHF1/HEY2; DISEASE; LIGAND AB Mutations in Notch receptors and their ligands have been identified as the cause of human congenital heart diseases, indicating the importance of the Notch signaling pathway during heart development. In our study, we use Cre-Lox technology to inactivate Notch2 in several cardiac cell lineages to determine the functional requirements for Notch2 during mammalian heart development. Inactivation of Notch2 in cardiac neural crest cells resulted in abnormally narrow aortas and pulmonary arteries due to a decrease in smooth muscle tissue. The reduction in smooth muscle tissue was not due to cell migration defects but instead was found to be caused by less proliferation in smooth muscle cells during mid to late gestation. Our findings demonstrate that Notch2 is required cell autonomously for proper formation of the heart outflow tract and provides insights into the role of Notch2 in vascular smooth muscle development and the cardiovascular defects associated with Alagille syndrome. C1 [Varadkar, Prajakta; Kraman, Matthew; Ma, Ge; McCright, Brent] US FDA, Div Cellular & Gene Therapies, Bethesda, MD 20892 USA. [Despres, Daryl] NIH, NINDS, MIF, Bethesda, MD 20892 USA. [Lozier, Julie] Jackson Lab, Bar Harbor, ME 04609 USA. RP McCright, B (reprint author), US FDA, Div Cellular & Gene Therapies, Bethesda, MD 20892 USA. EM brenton.mccright@fda.hhs.gov NR 29 TC 26 Z9 28 U1 0 U2 1 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1058-8388 J9 DEV DYNAM JI Dev. Dyn. PD APR PY 2008 VL 237 IS 4 BP 1144 EP 1152 DI 10.1002/dvdy.21502 PG 9 WC Anatomy & Morphology; Developmental Biology SC Anatomy & Morphology; Developmental Biology GA 287FY UT WOS:000254903700025 PM 18330927 ER PT J AU Nansel, TR Gellar, L McGill, A AF Nansel, Tonja R. Gellar, Lauren McGill, Adrienne TI Effect of varying glycemic index meals on blood glucose control assessed with continuous glucose monitoring in youth with type 1 diabetes on basalm-bolus insulin regimens SO DIABETES CARE LA English DT Article ID LIPID PROFILE; DIET; HEMOGLOBIN; CHILDREN; PEOPLE AB OBJECTIVE - The purpose of this study was to test the effect of high glycemic index (HGI) and low glycemic index (LGI) meals on blood glucose levels using continuous blood glucose monitoring in youths with type 1 diabetes. RESEARCH DESIGN AND METHODS - A total of 20 youths on basal-bolus regimens consumed macronutrient-matched HGI and LGI meals 1 day each in a controlled setting in varying order following consumption of a standardized evening meal. Medtronic MiniMed Continuous Glucose Monitoring Systems were used to assess blood glucose (BG) profiles. RESULTS - Participants demonstrated significantly lower daytime mean BG, BG area > 180 mg/dl, and high BG index when consuming LGI meals but no differences for daytime BG area < 70 mg/dl, daytime low BG index, or any nighttime values. Significantly more BG values < 80 mg/dl were treated on LGI days. CONCLUSIONS - Findings indicate that consumption of an LGI diet may reduce glucose excursions, improving glycemic control. C1 [Nansel, Tonja R.] NICHHD, Div Epidemiol Stat & Prevent Res, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA. [Gellar, Lauren] Univ Massachusetts, Sch Med, Clin & Populat Hlth Res Div, Worcester, MA USA. [McGill, Adrienne] Univ Maryland, Sch Med, Dept Pediat, Growth & Nutr Div, Baltimore, MD 21201 USA. RP Nansel, TR (reprint author), 6100 Execut Blvd,Rm 7B13R,MSC 7510, Bethesda, MD 20892 USA. EM nanselt@mail.nih.gov OI Nansel, Tonja/0000-0002-8298-7595 FU Intramural NIH HHS [Z99 HD999999] NR 17 TC 32 Z9 32 U1 0 U2 2 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA SN 0149-5992 J9 DIABETES CARE JI Diabetes Care PD APR PY 2008 VL 31 IS 4 BP 695 EP 697 DI 10.2337/dc07-1879 PG 3 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 282UE UT WOS:000254591900013 PM 18202243 ER PT J AU Koh, KK Quon, M Han, SH Lee, Y Ahn, JY Kim, SJ Koh, Y Shin, EK AF Koh, Kwang Kon Quon, Michael J. Han, Seung Hwan Lee, Yonghee Ahn, Jeong Yeal Kim, Soo Jin Koh, Yesl Shin, Eak Kyun TI Simvastatin improves flow-mediated dilation but reduces adiponectin levels and insulin sensitivity in hypercholesterolemic patients SO DIABETES CARE LA English DT Article; Proceedings Paper CT 80th Annual Scientific Session of the American-Heart-Association CY NOV 04-07, 2007 CL Orlando, FL SP Amer Heart Assoc ID RANDOMIZED CONTROLLED-TRIAL; HYPERTENSIVE PATIENTS; METABOLIC PARAMETERS; NONDIABETIC PATIENTS; ATORVASTATIN; RESISTANCE; PRAVASTATIN; CORONARY; RISK; INHIBITION AB OBJECTIVE - We hypothesized that simvastatin may reduce adiponectin levels and insulin sensitivity in hypercholesterolemic patients. RESEARCH DESIGN AND METHODS - This was a randomized, double-blind, placebo-controlled, parallel study. Age, sex, and BMI were matched. Thirty-two patients were given placebo, and 30, 32, 31, and 31 patients were given daily 10, 20, 40, and 80 mg simvastatin, respectively, during a 2-month treatment period. RESULTS - Simvastatin doses of 10, 20, 40, and 80 mg significantly reduced total cholesterol (mean changes 27, 25, 37, and 38%), LDL cholesterol (39, 38, 52, and 54%), and apolipoprotein B levels (24, 30, 36, and 42%) and improved flow-mediated dilation (FMD) (68, 40, 49, and 63%) after 2 months of therapy compared with baseline (P < 0.001 by paired t test) or compared with placebo (P < 0.001 by ANOVA). Simvastatin doses of 10, 20, 40, and 80 mg significantly decreased plasma adiponectin levels (4, 12, 5, and 10%) and insulin sensitivity (determined by the Quantitative Insulin-Sensitivity Check Index [QUICKI]) (5, 8, 6, and 6%) compared with baseline (P < 0.05 by paired t test) or compared with placebo (P = 0.011 for adiponectin and P = 0.034 for QUICKI by ANOVA). However, the magnitudes of these percent changes (FMD, adiponectin, and QUICKI) were not significantly different among four different doses of simvastatin despite dose-dependent changes in the reduction of apolipoprotein B levels. CONCLUSIONS - Simvastatin significantly improved endothelium-dependent dilation, but reduced adiponectin levels and insulin sensitivity in hypercholesterolemic patients independent of dose and the extent of apolipoprotein B reduction. C1 [Koh, Kwang Kon; Han, Seung Hwan; Ahn, Jeong Yeal; Kim, Soo Jin; Shin, Eak Kyun] Gachon Univ, Gil Med Ctr, Vasc Med & Atherosclerosis Unit, Div Cardiol, Inchon 405760, South Korea. [Koh, Kwang Kon; Han, Seung Hwan; Ahn, Jeong Yeal; Kim, Soo Jin; Shin, Eak Kyun] Gachon Univ, Gil Med Ctr, Vasc Med & Atherosclerosis Unit, Div Lab Med, Inchon 405760, South Korea. [Quon, Michael J.] Natl Inst Hlth, Natl Ctr Complementary & Alternat Med, Diabet Unit, Bethesda, MD USA. [Lee, Yonghee] Ewha Womans Univ, Dept Stat, Seoul, South Korea. [Koh, Yesl] Northwestern Univ, Weinberg Coll Arts & Sci, Evanston, IL USA. RP Koh, KK (reprint author), Gachon Univ, Gil Med Ctr, Vasc Med & Atherosclerosis Unit, Div Cardiol, 1198 Kuwol Dong, Inchon 405760, South Korea. EM kwangk@gilhospital.com RI Quon, Michael/B-1970-2008; OI Quon, Michael/0000-0002-9601-9915; Quon , Michael /0000-0002-5289-3707 FU Intramural NIH HHS [Z01 AT000001-07] NR 28 TC 75 Z9 76 U1 0 U2 0 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA SN 0149-5992 J9 DIABETES CARE JI Diabetes Care PD APR PY 2008 VL 31 IS 4 BP 776 EP 782 DI 10.2337/dc07-2199 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 282UE UT WOS:000254591900029 PM 18184901 ER PT J AU Humphrey, GW Wang, YH Hirai, T Padmanabhan, R Panchision, DM Newell, LF McKay, RDG Howard, BH AF Humphrey, Glen W. Wang, Yong-Hong Hirai, Tazuko Padmanabhan, Raji Panchision, David M. Newell, Laura F. McKay, Ronald D. G. Howard, Bruce H. TI Complementary roles for histone deacetylases 1, 2, and 3 in differentiation of pluripotent stem cells SO DIFFERENTIATION LA English DT Article DE HDAC; dominant negative; transduction; cell fate; MEL; neural stem cell ID HISTONE DEACETYLASE ACTIVITY; TRANSCRIPTIONAL REPRESSION; NEURONAL DIFFERENTIATION; DNA METHYLATION; PPAR-GAMMA; COMPLEX; INHIBITORS; CHROMATIN; SMRT; RB AB In eukaryotic cells, covalent modifications to core histones contribute to the establishment and maintenance of cellular phenotype via regulation of gene expression. Histone acetyltransferases (HATs) cooperate with histone deacetylases (HDACs) to establish and maintain specific patterns of histone acetylation. HDAC inhibitors can cause pluripotent stem cells to cease proliferating and enter terminal differentiation pathways in culture. To better define the roles of individual HDACs in stem cell differentiation, we have constructed "dominant-negative" stem cell lines expressing mutant, Flag-tagged HDACs with reduced enzymatic activity. Replacement of a single residue (His --> Ala) in the catalytic center reduced the activity of HDACs 1 and 2 by 80%, and abolished HDAC3 activity; the mutant HDACs were expressed at similar levels and in the same multiprotein complexes as wild-type HDACs. Hexamethylene bisacetamide-induced MEL cell differentiation was potentiated by the individual mutant HDACs, but only to 2%, versus 60% for an HDAC inhibitor, sodium butyrate, suggesting that inhibition of multiple HDACs is required for full potentiation. Cultured E14.5 cortical stem cells differentiate to neurons, astrocytes, and oligodendrocytes upon withdrawal of basic fibroblast growth factor. Transduction of stem cells with mutant HDACs 1, 2, or 3 shifted cell fate choice toward oligodendrocytes. Mutant HDAC2 also increased differentiation to astrocytes, while mutant HDAC1 reduced differentiation to neurons by 50%. These results indicate that HDAC activity inhibits differentiation to oligodendrocytes, and that HDAC2 activity specifically inhibits differentiation to astrocytes, while HDAC1 activity is required for differentiation to neurons. C1 [Humphrey, Glen W.; Wang, Yong-Hong; Hirai, Tazuko; Howard, Bruce H.] NICHHD, Lab Mol Growth Regulat, Bethesda, MD 20892 USA. [Padmanabhan, Raji; Panchision, David M.; Newell, Laura F.; McKay, Ronald D. G.] NINDS, Mol Biol Lab, NIH, Bethesda, MD 20892 USA. RP Howard, BH (reprint author), NICHHD, Lab Mol Growth Regulat, Bethesda, MD 20892 USA. EM howard@helix.nih.gov FU Intramural NIH HHS; NICHD NIH HHS [P30 HD040677, P30HD40677] NR 48 TC 35 Z9 36 U1 0 U2 10 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0301-4681 J9 DIFFERENTIATION JI Differentiation PD APR PY 2008 VL 76 IS 4 BP 348 EP 356 DI 10.1111/j.1432-0436.2007.00232.x PG 9 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA 286PC UT WOS:000254857100004 PM 18021260 ER PT J AU Falk, DE Yi, HY Hilton, ME AF Falk, Daniel E. Yi, Hsiao-ye Hilton, Michael E. TI Age of onset and temporal sequencing of lifetime DSM-IV alcohol use disorders relative to comorbid mood and anxiety disorders SO DRUG AND ALCOHOL DEPENDENCE LA English DT Article DE age of onset; mood disorders; anxiety disorders; alcohol use disorders; comorbidity; NESARC; epidemiology; temporal Sequencing ID SUBSTANCE USE DISORDERS; NATIONAL EPIDEMIOLOGIC SURVEY; SELF-REPORTED AGE; MENTAL-DISORDERS; PSYCHIATRIC-DISORDERS; SECONDARY DEPRESSION; GENERAL-POPULATION; MAJOR DEPRESSION; ABUSE DIAGNOSES; SEX-DIFFERENCES AB Context: Understanding the temporal sequencing of alcohol use disorders (AUDs) and comorbid mood and anxiety disorders may help to disentangle the etiological underpinnings of comorbidity. Methodological limitations of previous studies, however, may have led to inconsistent or inconclusive findings. Objective: To describe the temporal sequencing of the onset of AUDs relative to the onset of specific comorbid mood and anxiety disorders using a large, nationally representative survey. Results: AUD onset tended to follow the onset of 2 of the 9 mood and anxiety disorders (specific and social phobia). The onset of alcohol abuse tended to precede the onset of 5 of the 9 mood and anxiety disorders (GAD, panic, panic with agoraphobia, major depression, and dysthymia), whereas the onset of alcohol dependence tended to precede the onset of only 2 of the 9 mood and anxiety disorders (GAD and panic). Lag times between primary and subsequent disorders generally ranged from 7 to 16 years. Comorbid individuals whose alcohol dependence came after panic with agoraphobia, hypomania, and GAD had increased risk of persistent alcohol dependence. Conclusion: Alcohol abuse, but not dependence, precedes many mood and anxiety disorders. If the primary disorder does in fact play a causative or contributing role in the development of the subsequent disorder, this role can best be described as "temporally distal." However, in assessing the risk for persistent alcohol dependence, clinicians should not only consider the type of comorbid mood/anxiety disorder, but also the temporal ordering of these disorders. (C) 2007 Elsevier Ireland Ltd. All rights reserved. C1 [Falk, Daniel E.; Yi, Hsiao-ye] CSR Inc, Alcohol Epidemiol Data Syst, Arlington, VA 22201 USA. [Hilton, Michael E.] NIAAA, NIH, Bethesda, MD 20892 USA. RP Falk, DE (reprint author), CSR Inc, Alcohol Epidemiol Data Syst, 2107 Wilson Blvd,Suite 100, Arlington, VA 22201 USA. EM dfalk@csrincorporated.com FU NIAAA NIH HHS [N01 AA032007, N01 AA32007, N01AA32007] NR 49 TC 58 Z9 61 U1 3 U2 10 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0376-8716 J9 DRUG ALCOHOL DEPEN JI Drug Alcohol Depend. PD APR 1 PY 2008 VL 94 IS 1-3 BP 234 EP 245 DI 10.1016/j.drugalcdep.2007.11.022 PG 12 WC Substance Abuse; Psychiatry SC Substance Abuse; Psychiatry GA 273KS UT WOS:000253929700028 PM 18215474 ER PT J AU Catapano, LA Manji, HK AF Catapano, Lisa A. Manji, Husseini K. TI Kinases as drug targets in the treatment of bipolar disorder SO DRUG DISCOVERY TODAY LA English DT Review ID GLYCOGEN-SYNTHASE KINASE-3; REDUCES TAU-PHOSPHORYLATION; WNT SIGNALING PATHWAY; PROTEIN-KINASE; ALZHEIMERS-DISEASE; CELL-SURVIVAL; MOLECULAR-MECHANISM; NEURONAL POLARITY; LITHIUM-CARBONATE; MOOD STABILIZERS AB Bipolar disorder is one of the most severely debilitating of all medical illnesses, and is increasingly recognized as a major public health problem. For many patients with bipolar disorder, current pharmacotherapy is insufficient. Exciting recent data suggest that regulation of signaling molecules may be involved in the pathophysiology of the disorder, and in the mechanisms of action of mood stabilizers and antidepressants. Through our developing understanding of the biochemical targets of effective medications, several potential targets for new therapies have emerged. This short review will focus on two of the most promising such targets: glycogen synthase-3 and protein kinase C. C1 NIH, Lab Mol Pathophysiol Mood, Bethesda, MD 20892 USA. NIH, Anxiety Disorders Program, Bethesda, MD 20892 USA. RP Catapano, LA (reprint author), NIH, Lab Mol Pathophysiol Mood, Bldg 10, Bethesda, MD 20892 USA. EM manji@nih.gov NR 81 TC 16 Z9 16 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-6446 J9 DRUG DISCOV TODAY JI Drug Discov. Today PD APR PY 2008 VL 13 IS 7-8 BP 295 EP 302 DI 10.1016/j.drudis.2008.02.007 PG 8 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 295LI UT WOS:000255475600004 PM 18405841 ER PT J AU De Azambuja, E McCaskill-Stevens, W Quinaux, E Buyse, M Crown, J Francis, P Gelber, R Piccart-Gebhart, M AF De Azambuja, E. McCaskill-Stevens, W. Quinaux, E. Buyse, M. Crown, J. Francis, P. Gelber, R. Piccart-Gebhart, M. TI The effect of body mass index (BMI) on disease-free and overall survival in node-positive breast cancer treated with docetaxel and doxorubicin-containing adjuvant chemotherapy: the experience of the BIG 02-98 trial SO EJC SUPPLEMENTS LA English DT Meeting Abstract CT 6th European Breast Cancer Conference CY APR 15-19, 2008 CL Berlin, GERMANY C1 [De Azambuja, E.] Inst Jules Bordet, Med Oncol Clin, B-1000 Brussels, Belgium. [McCaskill-Stevens, W.] NIH, Canc Prevent Div, Bethesda, MD 20892 USA. [Quinaux, E.; Buyse, M.] Int Inst Drug Dev, Louvain, Belgium. [Crown, J.] Breast Comm, Irish Clin Oncol Res Grp, Dublin, Ireland. [Francis, P.] ANZ BCTG & IBCSG, Peter MacCallum Canc Ctr, Melbourne, Australia. [Gelber, R.] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA. [Piccart-Gebhart, M.] Inst Jules Bordet, Dept Med, B-1000 Brussels, Belgium. NR 0 TC 0 Z9 0 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6349 J9 EJC SUPPL JI EJC Suppl. PD APR PY 2008 VL 6 IS 7 BP 58 EP 59 DI 10.1016/S1359-6349(08)70345-8 PG 2 WC Oncology SC Oncology GA 313TD UT WOS:000256762000052 ER PT J AU Anderson, BO Yip, CH Smith, RA Shyyan, R Sener, SF Enius, AE Carlson, RW Azavedo, E Harford, JB AF Anderson, B. O. Yip, C. H. Smith, R. A. Shyyan, R. Sener, S. F. Enius, A. E. Carlson, R. W. Azavedo, E. Harford, J. B. TI The Breast Health Global Initiative: a catalyst for cancer control in limited resource countries SO EJC SUPPLEMENTS LA English DT Meeting Abstract CT 6th European Breast Cancer Conference CY APR 15-19, 2008 CL Berlin, GERMANY C1 [Anderson, B. O.] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA. [Yip, C. H.] Univ Malaya, Med Ctr, Dept Surg, Kuala Lumpur, Malaysia. [Smith, R. A.] Amer Canc Soc, Canc Control Sci Dept, Atlanta, GA 30329 USA. [Shyyan, R.] Lviv Reg Canc Ctr, Dept Surg, Lvov, Ukraine. [Sener, S. F.] Northwestern Univ, Dept Surg, Evanston, IL USA. [Enius, A. E.] Canc Inst Ion Chirocuta, Dept Breast Tumors, Cluj Napoca, Romania. [Carlson, R. W.] Stanford Univ, Div Med Oncol, Stanford, CA 94305 USA. [Azavedo, E.] Karolinska Univ Hosp, Stockholm, Sweden. [Harford, J. B.] Natl Canc Inst, Off Int Affairs, Bethesda, MD USA. RI Yip, Cheng-Har/B-1909-2010 NR 0 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6349 J9 EJC SUPPL JI EJC Suppl. PD APR PY 2008 VL 6 IS 7 BP 166 EP 167 DI 10.1016/S1359-6349(08)70705-5 PG 2 WC Oncology SC Oncology GA 313TD UT WOS:000256762000408 ER PT J AU Duchnowska, R Jassem, J Szczylik, C Sledge, GW Li, L Czartoryska-Arlukowicz, B Radeckae, B Sosinska, K Steeg, P Badve, S AF Duchnowska, R. Jassem, J. Szczylik, C. Sledge, G. W., Jr. Li, L. Czartoryska-Arlukowicz, B. Radeckae, B. Sosinska, K. Steeg, P. Badve, S. TI Prediction of brain relapse by gene expression analysis in HER2-positive metastatic breast cancer patients SO EJC SUPPLEMENTS LA English DT Meeting Abstract CT 6th European Breast Cancer Conference CY APR 15-19, 2008 CL Berlin, GERMANY C1 [Duchnowska, R.; Szczylik, C.] Mil Inst Med, Dept Oncol, Warsaw, Poland. [Jassem, J.; Sosinska, K.] Med Univ, Dept Radiotherapy & Oncol, Gdansk, Poland. [Sledge, G. W., Jr.] Indiana Univ, Dept Med, Indianapolis, IN USA. [Czartoryska-Arlukowicz, B.] Reg Canc Ctr, Dept Oncol, Bialystok, Poland. [Li, L.] Indiana Univ, Div Biostat, Indianapolis, IN 46204 USA. [Radeckae, B.] Reg Canc Ctr, Dept Oncol, Opole, Poland. [Steeg, P.] NCI, Mol Pharmacol Lab, Bethesda, MD 20892 USA. [Badve, S.] Indiana Univ, Sch Med, Dept Pathol & Lab Med, Indianapolis, IN USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6349 J9 EJC SUPPL JI EJC Suppl. PD APR PY 2008 VL 6 IS 7 BP 193 EP 193 DI 10.1016/S1359-6349(08)70796-1 PG 1 WC Oncology SC Oncology GA 313TD UT WOS:000256762000498 ER PT J AU Verweij, PE Varga, J Houbraken, J Rijs, AJMM VerduynLunel, FM Blijlevens, NMA Shea, YR Holland, SM Warris, A Melchers, WJG Samson, RA AF Verweij, Paul E. Varga, Janos Houbraken, Jos Rijs, Antonius J. M. M. VerduynLunel, Frans M. Blijlevens, Nicole M. A. Shea, Yvonne R. Holland, Steven M. Warris, Adilia Melchers, Willem J. G. Samson, Robert A. TI Emericella quadrilineata as cause of invasive aspergillosis SO EMERGING INFECTIOUS DISEASES LA English DT Article ID CHRONIC GRANULOMATOUS-DISEASE; NIDULANS INFECTION; FUNGAL SINUSITIS; AMPHOTERICIN-B; FUMIGATUS; OSTEOMYELITIS; ONYCHOMYCOSIS; PATIENT; TERREUS AB We noted a cluster of 4 cases of infection or colonization by Emericella spp., identified by sequence-based analysis as E. quadrilineata. Sequence-based analysis of an international collection of 33 Emericella isolates identified 12 as E. nidulans, all 12 of which had previously been identified by morphologic methods as E nidulans. For 12 isolates classified as E. quadrilineata, only 6 had been previously identified accordingly. E. nidulans was less susceptible than E. quadrilineata to amphotericin B (median MICs 2.5 and 0.5 mg/L, respectively, p<0.05); E. quadrilineata was less susceptible than E. nidulans to caspofungin (median MICs, 1.83 and 0.32 mg/L, respectively, p<0.05). These data indicate that sequence-based identification is more accurate than morphologic examination for identifying Emericella spp. and that correct species demarcation and in vitro susceptibility testing may affect patient management. C1 [Verweij, Paul E.; Rijs, Antonius J. M. M.; VerduynLunel, Frans M.; Blijlevens, Nicole M. A.; Warris, Adilia; Melchers, Willem J. G.] Radboud Univ Nijmegen, Med Ctr, NL-6500 HB Nijmegen, Netherlands. [Varga, Janos; Houbraken, Jos; Samson, Robert A.] Cent Bur Schimmelcultures, Fungal Biodiversity Ctr, Utrecht, Netherlands. [Varga, Janos] Univ Szeged, Szeged, Hungary. [Shea, Yvonne R.; Holland, Steven M.] NIH, Bethesda, MD 20892 USA. RP Verweij, PE (reprint author), Radboud Univ Nijmegen, Med Ctr, POB 9101, NL-6500 HB Nijmegen, Netherlands. EM p.verweij@mmb.umcn.nl RI Warris, Adilia/F-4882-2010; Verweij, P.E./H-8108-2014; Blijlevens, N.M.A./H-8012-2014; Warris, A./L-4745-2015; Melchers, Willem/C-8819-2015 OI Melchers, Willem/0000-0002-5446-2230 NR 38 TC 29 Z9 30 U1 0 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD APR PY 2008 VL 14 IS 4 BP 566 EP 572 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 282VJ UT WOS:000254595000005 PM 18394273 ER PT J AU Mbulaiteye, SM Pfeiffer, RM Dolan, B Tsang, VCW Noh, J Mikhail, NNH Abdel-Hamid, M Hashem, M Whitby, D Strickland, GT Goedert, JJ AF Mbulaiteye, Sam M. Pfeiffer, Ruth M. Dolan, Bryan Tsang, Victor C. W. Noh, John Mikhail, Nabiel N. H. Abdel-Hamid, Mohamed Hashem, Mohamed Whitby, Denise Strickland, G. Thomas Goedert, James J. TI Seroprevalence and risk factors for human herpesvirus 8 infection, rural egypt SO EMERGING INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT 9th International Workshop on Kaposis Sarcoma Associated Herpesvirus and Related Agents CY JUL 12-15, 2006 CL Cape Cod, MA ID SARCOMA-ASSOCIATED HERPESVIRUS; HEPATITIS-C VIRUS; SICKLE-CELL-DISEASE; MOTHER-TO-CHILD; KAPOSIS-SARCOMA; SCHISTOSOMA-MANSONI; TRANSMISSION; EPIDEMIOLOGY; AFRICA; ASSAYS AB To determine whether human herpesvirus 8 (HHV-8) is associated with schistosomal and hepatitis C virus infections in Egypt, we surveyed 965 rural household participants who had been tested for HHV-8 and schistosomal infection (seroprevalence 14.2% and 68.6%, respectively, among those <15 years of age, and 24.2% and 72.8%, respectively, among those 2:15 years of age). Among adults, HHV-8 seropositivity was associated with higher age, lower education, dental treatment, tattoos, >10 lifetime injections, and hepatitis C virus seropositivity. In adjusted analyses, HHV-8 seropositivity was associated with dental treatment among men (odds ratio [OR] 2.4, 95% confidence interval [CI] 1.1-5.2) and hepatitis C virus seropositivity among women (OR 3.3, 95% Cl 1.4-7.9). HHV-8 association with antischistosomal antibodies was not significant for men (OR 2.1, 95% CI 0.3-16.4), but marginal for women (OR 1.5, 95% Cl 1.0-2.5). Our findings suggest salivary and possible nosocomial HHV-8 transmission in rural Egypt. C1 [Mbulaiteye, Sam M.; Pfeiffer, Ruth M.; Dolan, Bryan; Goedert, James J.] NCI, Rockville, MD USA. [Whitby, Denise] NCI, Frederick, MD 21701 USA. [Abdel-Hamid, Mohamed; Hashem, Mohamed; Strickland, G. Thomas] Univ Maryland, Sch Med, Baltimore, MD 21201 USA. [Abdel-Hamid, Mohamed; Hashem, Mohamed] Natl Hepatol & Trop Med Res Inst, Cairo, Egypt. [Tsang, Victor C. W.; Noh, John] Ctr Dis Control & Prevent, Atlanta, GA USA. [Mikhail, Nabiel N. H.] Assiut Univ, Cairo, Egypt. RP Mbulaiteye, SM (reprint author), 6120 Execut Blvd,Execut Plaza S,Rm 7080, Rockville, MD 20852 USA. EM mbulaits@mail.nih.gov RI Pfeiffer, Ruth /F-4748-2011 NR 32 TC 11 Z9 11 U1 0 U2 1 PU CENTER DISEASE CONTROL PI ATLANTA PA ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD APR PY 2008 VL 14 IS 4 BP 586 EP 591 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 282VJ UT WOS:000254595000008 PM 18394276 ER PT J AU Gonzalez-Iglesias, AE Murano, T Li, S Tomic, M Stojilkovic, SS AF Gonzalez-Iglesias, Arturo E. Murano, Takayo Li, Shuo Tomic, Melanija Stojilkovic, Stanko S. TI Dopamine inhibits basal prolactin release in pituitary lactotrophs through pertussis toxin-sensitive and insensitive signaling pathways SO ENDOCRINOLOGY LA English DT Article ID PROTEIN-KINASE-C; RAT ANTERIOR-PITUITARY; BINDING-PROTEIN; D2-DOPAMINE RECEPTOR; ADENYLATE-CYCLASE; CALCIUM CURRENTS; CHROMAFFIN CELLS; CA2+ INFLUX; EXOCYTOSIS; SECRETION AB Dopamine D2 receptors signal through the pertussis toxin (PTX)-sensitiveG(i/o) and PTX-insensitive G(z) proteins, as well as through a G protein-independent, beta-arrestin/glycogen synthase kinase-3-dependent pathway. Activation of these receptors in pituitary lactotrophs leads to inhibition of prolactin (PRL) release. It has been suggested that this inhibition occurs through the G(i/o)-alpha protein-mediated inhibition of cAMP production and/or G(i/o)-beta gamma dimer-mediated activation of inward rectifier K+ channels and inhibition of voltage-gated Ca2+ channels. Here we show that the dopamine agonist-induced inhibition of spontaneous Ca2+ influx and release of prestored PRL was preserved when cAMP levels were elevated by forskolin treatment. We further observed that dopamine agonists inhibited both spontaneous and depolarizationinduced Ca2+ influx in untreated but not in PTX-treated cells. This inhibition was also observed in cells with blocked inward rectifier K+ channels, suggesting that the dopamine effect on voltage-gated Ca2+ channel gating is sufficient to inhibit spontaneous Ca2+ influx. However, agonist-induced inhibition of PRL release was only partially relieved in PTX-treated cells, indicating that dopamine receptors also inhibit exocytosis downstream of voltage-gated Ca2+ influx. The PTX-insensitive step in agonist-induced inhibition of PRL release was not affected by the addition of wortmannin, an inhibitor of phosphatidylinositol 3-kinase, and lithium, an inhibitor of glycogen synthase kinase-3, but was attenuated in the presence of phorbol 12-myristate 13-acetate, which inhibits G(z) signaling pathway in a protein kinase C-dependent manner. Thus, dopamine inhibits basal PRL release by blocking voltage-gated Ca2+ influx through the PTX-sensitive signaling pathway and by desensitizing Ca2+ secretion coupling through the PTX-insensitive and protein kinase C-sensitive signaling pathway. C1 [Gonzalez-Iglesias, Arturo E.; Murano, Takayo; Li, Shuo; Tomic, Melanija; Stojilkovic, Stanko S.] NICHHD, Sect Cellular Signaling, Program Dev Neurosci, NIH, Bethesda, MD 20892 USA. RP Stojilkovic, SS (reprint author), NICHHD, Sect Cellular Signaling, Program Dev Neurosci, NIH, Bldg 49,Room 6A-36,49 Convent Dr, Bethesda, MD 20892 USA. EM stankos@helix.nih.gov RI Tomic, Melanija/C-3371-2016 FU Intramural NIH HHS NR 59 TC 18 Z9 18 U1 1 U2 4 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0013-7227 J9 ENDOCRINOLOGY JI Endocrinology PD APR PY 2008 VL 149 IS 4 BP 1470 EP 1479 DI 10.1210/en.2007-0980 PG 10 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 278DO UT WOS:000254264100006 PM 18096663 ER PT J AU Zappala, G Elbi, C Edwards, J Gorenstein, J Rechler, MM Bhattacharyya, N AF Zappala, Giovanna Elbi, Cem Edwards, Joanna Gorenstein, Julie Rechler, Matthew M. Bhattacharyya, Nisan TI Induction of apoptosis in human prostate cancer cells by insulin-like growth factor binding protein-3 does not require binding to retinoid X receptor-alpha SO ENDOCRINOLOGY LA English DT Article ID IGF-INDEPENDENT MECHANISMS; VITAMIN-D-RECEPTOR; NUCLEAR RECEPTOR; RXR-ALPHA; TARGETED DISRUPTION; SURFACE BINDING; CARCINOMA-CELLS; LEUKEMIA-CELLS; BETA RECEPTOR; AMINO-ACIDS AB IGF binding protein (IGFBP)-3 can induce apoptosis inhuman prostate cancer cells directly without sequestering IGF-I and -II. The molecular mechanisms responsible for the IGF-independent actions of IGFBP-3 remain unclear. IGFBP-3, a secreted protein, can be internalized and translocate to the nucleus. It binds to the nuclear retinoid X receptor (RXR)-alpha. Binding to RXR-alpha has been proposed to be required for IGFBP-3 to induce apoptosis. The present study tests this hypothesis in the PC-3 human prostate cancer cell line. PC-3 cells express RXR-alpha, and apoptosis is induced by incubation with RXR-specific ligand. A COOH-terminal region in IGFBP-3 (residues 215-232) contains a nuclear localization signal, and binding domains for RXR-alpha and heparin (HBD). Different combinations of the 11 amino acids in this region that differ from IGFBP-1, a related IGFBP, which does not localize to the nucleus or bind RXR-alpha, were mutated to the IGFBP-1 sequence. By confocal imaging, mutation of residues 228-KGRKR-232 in nonsecreted IGFBP-3 diminished its nuclear localization. IGFBP-3 binding to glutathione S-transferase-RXR-alpha only was lost when all 11 sites were mutated (HBD-11m-IGFBP-3). Expressed nuclear RXR-alpha did not transport cytoplasmic IGFBP-3 nuclear localization signal mutants that can bind RXR-alpha to the nucleus even after treatment with RXR ligand. Expressed HBD-11m-IGFBP-3 still induced apoptosis in PC-3 cells in an IGF-independent manner as determined by flow cytometric analysis of Annexin V staining. We conclude that in PC-3 cells, RXR-alpha is not required for the nuclear translocation of IGFBP-3 and that IGFBP-3 can induce apoptosis in human prostate cancer cells without binding RXR-alpha. C1 [Zappala, Giovanna; Edwards, Joanna; Rechler, Matthew M.; Bhattacharyya, Nisan] NIDDK, Diabet Branch, NIH, Bethesda, MD 20892 USA. [Elbi, Cem; Gorenstein, Julie] Merck Res Labs, Dept Canc Pathways, Boston, MA 02115 USA. RP Rechler, MM (reprint author), NIDDK, Diabet Branch, NIH, Bldg 10,Room 8D12,9000 Rockville Pike,MSC 1758, Bethesda, MD 20892 USA. EM mrechler@helix.nih.gov RI Edwards, Joanna/C-5067-2011 FU Intramural NIH HHS NR 64 TC 16 Z9 17 U1 0 U2 1 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0013-7227 J9 ENDOCRINOLOGY JI Endocrinology PD APR PY 2008 VL 149 IS 4 BP 1802 EP 1812 DI 10.1210/en.2007-1315 PG 11 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 278DO UT WOS:000254264100040 PM 18162523 ER PT J AU Marino, R Hegde, A Barnes, KM Schrier, L Emons, JA Nilsson, O Baron, J AF Marino, Rose Hegde, Anita Barnes, Kevin M. Schrier, Lenneke Emons, Joyce A. Nilsson, Ola Baron, Jeffrey TI Catch-up growth after hypothyroidism is caused by delayed growth plate senescence SO ENDOCRINOLOGY LA English DT Article ID EPIPHYSEAL FUSION; RESTING ZONE; RAT; DIFFERENTIATION; EXPRESSION; CARTILAGE; BONE; OSTEOPROTEGERIN; CHONDROADHERIN; PROLIFERATION AB Catch-up growth is defined as a linear growth rate greater than expected for age after a period of growth inhibition. We hypothesized that catch-up growth occurs because growth-inhibiting conditions conserve the limited proliferative capacity of growth plate chondrocytes, thus slowing the normal process of growth plate senescence. When the growth-inhibiting condition resolves, the growth plates are less senescent and therefore grow more rapidly than normal for age. To test this hypothesis, we administered propylthiouracil to newborn rats for 8 wk to induce hypothyroidism and then stopped the propylthiouracil to allow catch-up growth. In untreated controls, the growth plates underwent progressive, senescent changes in multiple functional and structural characteristics. We also identified genes that showed large changes in mRNA expression in growth plate and used these changes as molecular markers of senescence. In treated animals, after stopping propylthiouracil, these functional, structural, and molecular senescent changes were delayed, compared with controls. This delayed senescence included a delayed decline in longitudinal growth rate, resulting in catch-up growth. The findings demonstrate that growth inhibition due to hypothyroidism slows the developmental program of growth plate senescence, including the normal decline in the rate of longitudinal bone growth, thus accounting for catch-up growth. C1 [Marino, Rose; Hegde, Anita; Barnes, Kevin M.; Schrier, Lenneke; Emons, Joyce A.; Nilsson, Ola; Baron, Jeffrey] NICHHD, NIH, Dev Endocrinol Branch, Bethesda, MD 20892 USA. [Marino, Rose] Massachusetts Gen Hosp Children, Pediat Endocrinol Unit, Boston, MA 02114 USA. [Emons, Joyce A.] Leiden Univ, Med Ctr, Dept Pediat, NL-2300 RC Leiden, Netherlands. [Nilsson, Ola] Karolinska Inst, Ctr Mol Med & Pediat, SE-17176 Stockholm, Sweden. Karolinska Univ Hosp, SE-17176 Stockholm, Sweden. RP Baron, J (reprint author), NICHHD, NIH, Dev Endocrinol Branch, Bldg CRC,Room 1-3330,10 Ctr Dr MSC 1103, Bethesda, MD 20892 USA. EM jeffrey.baron@nih.gov OI Nilsson, Ola/0000-0002-9986-8138 FU Intramural NIH HHS NR 30 TC 29 Z9 30 U1 0 U2 3 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0013-7227 J9 ENDOCRINOLOGY JI Endocrinology PD APR PY 2008 VL 149 IS 4 BP 1820 EP 1828 DI 10.1210/en.2007-0993 PG 9 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 278DO UT WOS:000254264100042 PM 18174286 ER PT J AU Ma, XC Chen, C Krausz, KW Idle, JR Gonzalez, FJ AF Ma, Xiaochao Chen, Chi Krausz, Kristopher W. Idle, Jeffrey R. Gonzalez, Frank J. TI A metabolomic perspective of melatonin metabolism in the mouse SO ENDOCRINOLOGY LA English DT Article ID N-ACETYL-SEROTONIN; URINARY METABOLITES; EXOGENOUS MELATONIN; DRUG-METABOLISM; PINEAL-GLAND; MICE; N-1-ACETYL-N-2-FORMYL-5-METHOXYKYNURAMINE; OXIDATION; 6-HYDROXY-MELATONIN; 6-HYDROXYMELATONIN AB Metabolism of melatonin (MEL) in mouse was evaluated through a metabolomic analysis of urine samples from control and MEL-treated mice. Besides identifying seven known MEL metabolites (6-hydroxymelatonin glucuronide, 6-hydroxymelatonin sulfate, N-acetylserotonin glucuronide, N-acetylserotonin sulfate, 6-hydroxymelatonin, 2-oxomelatonin, 3-hydroxymelatonin), principal components analysis of urinary metabolomes also uncovered seven new MEL metabolites, including MEL glucuronide, cyclic MEL, cyclic N-acetylserotonin glucuronide, cyclic 6-hydroxymelatonin; 5-hydroxyindole-3-acetaldehyde, di-hydroxymelatonin and its glucuronide conjugate. However, N-1-acetyl-N-2-formyl-5-methoxy-kynuramine and N-1-acetyl-(5)-methoxy-kynuramine, known as MEL antioxidant products, were not detected in mouse urine. Metabolite profiling of MEL further indicated that 6-hydroxymelatonin glucuronide was the most abundant MEL metabolite in mouse urine, which comprised 75, 65, and 88% of the total MEL metabolites in CBA, C57/BL6, and 129Sv mice, respectively. Chemical identity of 6-hydroxymelatonin glucuronide was confirmed by deconjugation reactions using beta-glucuronidase and sulfatase. Compared with wild-type and CYP1A2-humanized mice, Cyp1a2-null mice yielded much less 6-hydroxymelatonin glucuronide (similar to 10%) but more N-acetylserotonin glucuronide (similar to 195%) and MEL glucuronide (similar to 220%) in urine. In summary, MEL metabolism in mouse was recharacterized by using a metabolomic approach, and the MEL metabolic map was extended to include seven known and seven novel pathways. This study also confirmed that 6-hydroxymelatonin glucuronide was the major MEL metabolite in the mouse, and suggested that there was no interspecies difference between humans and mice with regard to CYP1A2-mediated metabolism of MEL, but a significant difference in phase II conjugation, yielding 6-hydroxymelatonin glucuronide in the mouse and 6-hydroxymelatonin sulfate in humans. C1 [Ma, Xiaochao; Chen, Chi; Krausz, Kristopher W.; Gonzalez, Frank J.] NCI, Lab Metab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. [Idle, Jeffrey R.] Charles Univ Prague, Fac Med 1, Inst Pharmacol, Prague 12800, Czech Republic. RP Gonzalez, FJ (reprint author), NCI, Lab Metab, Ctr Canc Res, NIH, Bldg 37,Room 3106, Bethesda, MD 20892 USA. EM fjgonz@helix.nih.gov RI Chen, Chi/B-4618-2008; OI Idle, Jeff/0000-0002-6143-1520 FU Intramural NIH HHS; NIAID NIH HHS [U19 AI067773, U19 AI 067773-02] NR 40 TC 31 Z9 31 U1 0 U2 8 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0013-7227 J9 ENDOCRINOLOGY JI Endocrinology PD APR PY 2008 VL 149 IS 4 BP 1869 EP 1879 DI 10.1210/en.2007-1412 PG 11 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 278DO UT WOS:000254264100047 PM 18187545 ER PT J AU Drew, CH Barnes, MI Phelps, J Van Houten, B AF Drew, Christina H. Barnes, Martha I. Phelps, Jerry Van Houten, Bennett TI NIEHS extramural global environmental health portfolio: Opportunities for collaboration SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article DE global health; partnerships; science assessment AB BACKGROUND: Global environmental health has emerged as a critical topic for environmental health researchers and practitioners. Estimates of the environmental contribution of total worldwide disease burden range from 25 to 33%. OBJECTIVE: We reviewed grants funded by the National Institute of Environmental Health Sciences (NIEHS) during 2005-2007 to evaluate the costs and scientific composition of the global environmental health portfolio, with the ultimate aim of strengthening global environmental health research partnerships. METHODS/RESULTS: We examined NIEHS grant research databases to identify the global environmental health portfolio. In the past 3 fiscal years (2005-2007), the NIEHS funded 57 scientific research projects in 37 countries, at an estimated cost of $30 million. Metals such as arsenic, methylmercury, and lead are the most frequently studied toxic agents, but a wide range of stressors, routes of exposure, and agents are addressed in the portfolio. CONCLUSIONS: The portfolio analysis indicates that there is a firm foundation of research activities upon which additional global environmental health partnerships could be encouraged. Current data structures could be strengthened to support more automated analysis of grantee information. C1 [Drew, Christina H.; Barnes, Martha I.; Phelps, Jerry; Van Houten, Bennett] NIEHS, Program Anal Branch, Div Extramural Res & Training, NIH,Dept Hlth Human Serv, Res Triangle Pk, NC 27709 USA. RP Drew, CH (reprint author), NIEHS, Program Anal Branch, Div Extramural Res & Training, NIH,Dept Hlth Human Serv, POB 12233 EC-28,111 TW Alexander Dr, Res Triangle Pk, NC 27709 USA. EM drewc@niehs.nih.gov NR 18 TC 5 Z9 5 U1 0 U2 2 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD APR PY 2008 VL 116 IS 4 BP 421 EP 425 DI 10.1289/ehp.11323 PG 5 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 282KL UT WOS:000254566500020 PM 18414621 ER PT J AU Suk, WA AF Suk, William A. TI A new day for global environmental health SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Editorial Material C1 NIEHS, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC 27709 USA. RP Suk, WA (reprint author), NIEHS, NIH, Dept Hlth & Human Serv, POB 12233, Res Triangle Pk, NC 27709 USA. EM suk@niehs.nih.gov NR 5 TC 3 Z9 3 U1 1 U2 1 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD APR PY 2008 VL 116 IS 4 BP A148 EP A149 DI 10.1289/ehp.11322 PG 2 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 282KL UT WOS:000254566500001 PM 18414601 ER PT J AU Galperin, MY AF Galperin, Michael Y. TI The dawn of synthetic genomics SO ENVIRONMENTAL MICROBIOLOGY LA English DT Editorial Material ID BACILLUS-CEREUS GROUP; BACTERIAL KIDNEY-DISEASE; CHLOROFLEXUS-AURANTIACUS; BORDETELLA-PETRII; METHANE OXIDATION; SP-NOV; RENIBACTERIUM-SALMONINARUM; WEIHENSTEPHANENSIS; VERRUCOMICROBIA; METHYLOTROPHY C1 Natl Inst Hlth, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20894 USA. RP Galperin, MY (reprint author), Natl Inst Hlth, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20894 USA. EM galperin@ncbi.nlm.nih.gov RI Galperin, Michael/B-5859-2013 OI Galperin, Michael/0000-0002-2265-5572 FU Intramural NIH HHS [Z99 LM999999] NR 39 TC 3 Z9 3 U1 0 U2 2 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1462-2912 J9 ENVIRON MICROBIOL JI Environ. Microbiol. PD APR PY 2008 VL 10 IS 4 BP 821 EP 825 DI 10.1111/j.1462-2920.2008.01581.x PG 5 WC Microbiology SC Microbiology GA 276EM UT WOS:000254124100001 PM 18353151 ER PT J AU Miller, MA Sentz, J Rabaa, MA Mintz, ED AF Miller, M. A. Sentz, J. Rabaa, M. A. Mintz, E. D. TI Global epidemiology of infections due to Shigella, Salmonella serotype Typhi, and exterotoxigenic Escherichia coli SO EPIDEMIOLOGY AND INFECTION LA English DT Editorial Material ID PERSISTENT DIARRHEA; CHILDHOOD DIARRHEA; MILLION CHILDREN; GROWTH; BRAZIL; REDUCTION; NORTHEAST; MORTALITY; DISEASES; CHOLERA C1 [Miller, M. A.; Sentz, J.; Rabaa, M. A.] NIH, Div Int Epidemiol & Pupolat Studies, Fogarty Int Ctr, Bethesda, MD 20892 USA. [Mintz, E. D.] Ctr Dis Control & Prevent, Enter Dis Epidemiol Branch, Natl Ctr Zoonot Vectorborne & Enter Dis, Atlanta, GA USA. RP Miller, MA (reprint author), 16 Ctr Dr, Bethesda, MD 20892 USA. EM millemar@mail.nih.gov FU PHS HHS [32143] NR 27 TC 5 Z9 5 U1 0 U2 3 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0950-2688 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD APR PY 2008 VL 136 IS 4 BP 433 EP 435 DI 10.1017/S095026880800040X PG 3 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 350FE UT WOS:000259337200001 PM 18461719 ER PT J AU Crump, JA Ram, PK Gupta, SK Miller, MA Mintz, ED AF Crump, J. A. Ram, P. K. Gupta, S. K. Miller, M. A. Mintz, E. D. TI Part I. Analysis of data gaps pertaining to Salmonella enterica serotype Typhi infections in low and medium human development index countries, 1984-2005 SO EPIDEMIOLOGY AND INFECTION LA English DT Review ID CONTROLLED FIELD TRIAL; VI-CAPSULAR POLYSACCHARIDE; CLINICAL-FEATURES; HOSPITALIZED CHILDREN; RISK-FACTORS; BONE-MARROW; CONJUGATE VACCINE; PARATYPHOID FEVER; COATED CAPSULES; YOUNG-CHILDREN AB There are only 10 contemporary, population-based studies of typhoid fever that evaluate disease incidence using blood Culture for confirmation of cases. Reported incidence ranged from 13 to 976/100000 persons per year. These studies are likely to have been done preferentially in high-incidence sites which makes generalization of data difficult. Only five of these Studies reported mortality. Of these the median (range) mortality was 0% (0-1 center dot 8%). Since study conditions usually involved enhanced clinical management of patients and the studies were not designed to evaluate mortality as an outcome, their usefulness for generalizing case-fatality rates is uncertain. No contemporary population-based studies reported rates of complications. Hospital-based typhoid fever Studies reported median (range) complication rates of 2 center dot 8% (0 center dot 6-4 center dot 9%) for intestinal perforation and case-fatality rates of 2 center dot 0% (0-14 center dot 8%). Rates of complications other than intestinal perforation were not reported in contemporary hospital-based studies. Hospital-based studies capture information on the most severe illnesses among persons who have access to health-care services limiting their generalizability. Only two Studies have informed the current understanding of typhoid fever age distribution Curves. Extrapolation from population-based Studies Suggests that most typhoid Fever occurs among young children in Asia. To reduce gaps in the Current understanding of typhoid fever incidence, complications, and case-fatality rate, large population-based studies using blood Culture confirmation of cases are needed in representative sites, especially in low and medium human development index countries outside Asia. C1 [Crump, J. A.; Ram, P. K.; Gupta, S. K.; Mintz, E. D.] Ctr Dis Control & Prevent, Enter Dis Epidemiol Branch, Natl Ctr Zoonot Vectorborne & Enter Dis, Atlanta, GA 30333 USA. [Miller, M. A.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. RP Crump, JA (reprint author), Ctr Dis Control & Prevent, Enter Dis Epidemiol Branch, Natl Ctr Zoonot Vectorborne & Enter Dis, Atlanta, GA 30333 USA. EM jcrump@cdc.gov FU U.S. National Institutes of Health, Fogarty International Center; Bill and Melinda Gates Foundation [32143] FX This work was supported in part by the U.S. National Institutes of Health Fogarty International Center and by grant number 32143 from the Bill and Melinda Gates Foundation Assessment of diarrhea disease burden and public health programs to control diarrhea in Asian Subcontinent and Africa NR 84 TC 43 Z9 43 U1 0 U2 5 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0950-2688 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD APR PY 2008 VL 136 IS 4 BP 436 EP 448 DI 10.1017/S0950168807009338 PG 13 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 350FE UT WOS:000259337200002 PM 17686194 ER PT J AU Vitiello, B AF Vitiello, Benedetto TI Effectively obtaining informed consent for child and adolescent participation in mental health research SO ETHICS & BEHAVIOR LA English DT Article DE children; research; consent; mental health ID RANDOMIZED CONTROLLED-TRIALS; NONBENEFICIAL RESEARCH; RESEARCH KNOWLEDGE; CLINICAL-RESEARCH; PARENTS; ASSENT; READABILITY; RISK; PSYCHOPHARMACOLOGY; UNDERSTAND AB With the recent expansion of child mental health research, more attention is being paid to the process of informed consent for research participation. For the consent to be truly informed, it is necessary that the relevant information be both disclosed and actually understood. Traditionally, much effort has gone to ensuring the comprehensiveness of consent/assent documents, which have progressively increased in length and complexity, whereas less attention has been paid to the comprehensibility of these documents. Available data indicate that many parent and children have difficulties appreciating the research nature of treatment studies and that a higher level of formal education among the parents is associated with a greater degree of understanding. Promising approaches to achieving truly informed research participation have emerged, such as additional time for parents to meet with the researchers and using postexplanation questionnaires for identifying issues in need of further clarification. Research is needed to develop and test strategies for improving the effectiveness of the informed consent process in child mental health. C1 [Vitiello, Benedetto] NIMH, Child & Adolescent Treatment & Prevent Intervent, Div Serv & Intervent Res, Bethesda, MD 20892 USA. RP Vitiello, B (reprint author), NIMH, Child & Adolescent Treatment & Prevent Intervent, Div Serv & Intervent Res, 6001 Execut Blvd,Room 7147, Bethesda, MD 20892 USA. EM bvitiell@mail.nih.gov NR 50 TC 1 Z9 2 U1 1 U2 3 PU LAWRENCE ERLBAUM ASSOC INC-TAYLOR & FRANCIS PI PHILADELPHIA PA 325 CHESTNUT STREET, STE 800, PHILADELPHIA, PA 19106 USA SN 1050-8422 J9 ETHICS BEHAV JI Ethics Behav. PD APR-SEP PY 2008 VL 18 IS 2-3 BP 182 EP 198 DI 10.1080/10508420802064234 PG 17 WC Ethics; Psychology, Multidisciplinary SC Social Sciences - Other Topics; Psychology GA 320MS UT WOS:000257239800005 ER PT J AU Wheat, LJ Walsh, TJ AF Wheat, L. J. Walsh, T. J. TI Diagnosis of invasive aspergillosis by galactomannan antigenemia detection using an enzyme immunoassay SO EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES LA English DT Review ID LINKED-IMMUNOSORBENT-ASSAY; BRONCHOALVEOLAR LAVAGE FLUID; CELL TRANSPLANT RECIPIENTS; CHAIN-REACTION ASSAY; CARE-UNIT PATIENTS; PULMONARY ASPERGILLOSIS; NEUTROPENIC PATIENTS; FUNGAL-INFECTIONS; CROSS-REACTIVITY; CIRCULATING GALACTOMANNAN AB Invasive aspergillosis is a serious and often fatal infection in patients who are neutropenic or have undergone solid organ or stem cell transplantation. Delayed diagnosis and therapy may lead to poor outcomes. Diagnosis may be facilitated by a test for galactomannan antigen detection using an enzyme immunoassay. Other rapid methods for diagnosis include (1 -> 3)-beta-D-glucan determination and polymerase chain reaction. The sensitivity and specificity of galactomannan antigenemia testing in serum and bronchoalveolar lavage specimens are high in patients with hematological malignancy, neutropenia, and receipt of stem-cell transplants. False positivity can be seen with concomitant administration of some antibiotics and infection by fungi other than Aspergillus. C1 [Wheat, L. J.] MiraVista Diagnost, MiraVista Diagnost & MiraBells Technol, Indianapolis, IN 46241 USA. [Walsh, T. J.] NCI, Pediat Oncol Branch, Immunocompromised Host Sect, Bethesda, MD 20892 USA. RP Wheat, LJ (reprint author), MiraVista Diagnost, MiraVista Diagnost & MiraBells Technol, 4444 Decatur Blvd,Suite 300, Indianapolis, IN 46241 USA. EM jwheat@miravistalabs.com NR 48 TC 67 Z9 76 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0934-9723 J9 EUR J CLIN MICROBIOL JI Eur. J. Clin. Microbiol. Infect. Dis. PD APR PY 2008 VL 27 IS 4 BP 245 EP 251 DI 10.1007/s10096-007-0437-7 PG 7 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA 277XR UT WOS:000254248500001 PM 18193305 ER PT J AU Korswagen, LA Huizing, M Simsek, S Janssen, JJWM Zweegman, S AF Korswagen, Lindy-Anne Huizing, Marjan Simsek, Suat Janssen, Jeroen J. W. M. Zweegman, Sonja TI A novel mutation in a Turkish patient with Hermansky-Pudlak syndrome type 5 SO EUROPEAN JOURNAL OF HAEMATOLOGY LA English DT Article DE Hermansky-Pudlak syndrome; albinism; platelet dysfunction; mutation analysis ID LYSOSOME-RELATED ORGANELLES; PROTEINS; COMPLEX; TRAFFICKING; BIOGENESIS; DEFECTS; BLOC-1; HPS5 AB The Hermansky-Pudlak syndrome (HPS) is a rare genetically heterogeneous autosomal recessive disorder, characterized by tyrosinase-positive oculocutaneous albinism, platelet dysfunction and lysosomal ceroid lipofuscin storage. This is caused by defects in lysosome-related organelles. In humans eight different types of the syndrome are known, of which a short overview is given. The clinical features and a novel mutation of a patient with HPS type 5 are described here. C1 [Korswagen, Lindy-Anne; Janssen, Jeroen J. W. M.; Zweegman, Sonja] Vrije Univ Amsterdam Med Ctr, Dept Haematol, NL-1007 MB Amsterdam, Netherlands. [Huizing, Marjan] NHGRI, Natl Inst Hlth, Med Genet Branch, Bethesda, MD 20892 USA. [Simsek, Suat] Vrije Univ Amsterdam Med Ctr, Dept Endocrinol Diabet Ctr, Amsterdam, Netherlands. RP Korswagen, LA (reprint author), Vrije Univ Amsterdam Med Ctr, Dept Haematol, POB 7057,Boelelaan 1117, NL-1007 MB Amsterdam, Netherlands. EM lindyanne_k@yahoo.com FU Intramural NIH HHS NR 24 TC 5 Z9 5 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0902-4441 J9 EUR J HAEMATOL JI Eur. J. Haematol. PD APR PY 2008 VL 80 IS 4 BP 356 EP 360 DI 10.1111/j.1600-0609.2007.01024.x PG 5 WC Hematology SC Hematology GA 270ZI UT WOS:000253758300014 PM 18182080 ER PT J AU Abban, G Yildirim, NB Jetten, AM AF Abban, G. Yildirim, N. B. Jetten, A. M. TI Regulation of the vitamin D receptor and cornifin beta expression in vaginal epithelium of the rats through vitamin D(3) SO EUROPEAN JOURNAL OF HISTOCHEMISTRY LA English DT Article DE vitamin D; vagina; cornifin beta; vitamin D receptor ID ACTIVATED PROTEIN-KINASE; P38 MAP KINASE; ENDOMETRIAL CANCER; TRANSCRIPTIONAL ACTIVATION; 1,25-DIHYDROXYVITAMIN D-3; POSTMENOPAUSAL WOMEN; HUMAN KERATINOCYTES; GENE-EXPRESSION; MAMMARY-GLAND; ANALOG EB1089 AB The aim of the present study was to determine the respective role of 1,25-dihydroxyvitamin D(3) on vaginal epithelium and 1,25-dihydroxyvitamin D(3) receptor expression in ovariectomized rats and vitamin D(3) treated rats. Bilateral ovariectomies were performed in 20 mature, non-pregnant Wistar female rats. All the animals were divided into 2 groups consisting of 10 rats each. Group I served as control. In group II, animals were injected intramuscularly with vitamin D(3) (50, 00 IU/kg). Two weeks after the injections, vaginas of animals in group I and group II were removed removed and processed for immunohistochemistry. Epithelial differentiation, 1,25-dihydroxyvitamin D(3) receptor and cornifin beta expression were investigated in vaginal epithelium of control group (ovariectomized) and vitamin D(3) treated rats. Vaginal epithelial cells from vitamin D(3) treated animals changed into highly- stratified keratinizing layers. 1,25-dihydroxyvitamin D(3) receptor and cornifin beta as a marker of squamous differentiation were present in ovariectomized rats treated with 1,25dihydroxyvitamin D(3). In contrast, cornifin beta and 1,25-dihydroxyvitamin D(3) receptor were absent in all layers of vaginal epithelium in control group. We demonstrated for the first time that 1,25-dihydroxyvitamin D3 induced proliferation of vaginal epithelium consistent with the cornifin beta expression and 1,25-dihydroxyvitamin D(3) up-regulated 1,25-dihydroxyvitamin D(3) receptor expression in vaginal epithelium. C1 [Yildirim, N. B.] Pamukkale Univ, Fac Med, Dept Obstet & Gynecol, Kinikli, Denizli, Turkey. [Jetten, A. M.] NIEHS, Cell Biol Sect, Pulm Pathobiol Lab, NIH, Res Triangle Pk, NC USA. RP Abban, G (reprint author), Pamukkale Univ, Sch Med, Dept Histol & Embryol, Fac Med, Kinikli, Denizli, Turkey. EM gabban@pau.edu.tr OI Jetten, Anton/0000-0003-0954-4445 NR 53 TC 6 Z9 7 U1 0 U2 0 PU PAGEPRESS PUBL PI PAVIA PA MEDITGROUP, VIA G BELLI, 4, PAVIA, 27100, ITALY SN 1121-760X J9 EUR J HISTOCHEM JI Eur. J. Histochem. PD APR-JUN PY 2008 VL 52 IS 2 BP 107 EP 114 PG 8 WC Cell Biology SC Cell Biology GA 322YE UT WOS:000257410400004 PM 18591157 ER PT J AU Shevach, EM Tran, DQ Davidson, TS Andersson, J AF Shevach, Ethan M. Tran, Dat Q. Davidson, Todd S. Andersson, John TI The critical contribution of TGF-beta to the induction of Foxp3 expression and regulatory T cell function SO EUROPEAN JOURNAL OF IMMUNOLOGY LA English DT Article DE Foxp3; IL-2; Regulatory T cells; TGF-beta ID GROWTH-FACTOR-BETA; DENDRITIC CELLS; CUTTING EDGE; AUTOIMMUNITY; SUPPRESSION; PHENOTYPE; IL-2 AB Stimulation of mouse CD4(+) T cells in the presence of TGF-beta results in the expression of Foxp3 and induction of T(reg) function. Stimulation of human CD4(+) T cells under similar conditions results in the expression of Foxp3, but the cells lack regulatory cell function. TGF-beta expressed on the surface of T(reg) also induces Foxp3 expression and T(reg) function in responder cells. Both of these mechanisms may play a role in vivo in the induction of antigen-specific extra-thymic T(reg). C1 NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA. RP Shevach, EM (reprint author), NIAID, Immunol Lab, NIH, Blg 10,Room 11N315, Bethesda, MD 20892 USA. EM EShevach@niaid.nih.gov RI Andersson, John/A-4436-2009; OI Andersson, John/0000-0003-2799-6349 FU Division of Intramural Research; NIAID FX All studies described in this paper were supported by funds from the Division of Intramural Research, NIAID. NR 16 TC 63 Z9 68 U1 0 U2 2 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 0014-2980 J9 EUR J IMMUNOL JI Eur. J. Immunol. PD APR PY 2008 VL 38 IS 4 BP 915 EP 917 DI 10.1002/eji.200738111 PG 3 WC Immunology SC Immunology GA 293SV UT WOS:000255355900032 PM 18395859 ER PT J AU Belkaid, Y AF Belkaid, Yasmine TI Role of Foxp3-positive regulatory T cells during infection SO EUROPEAN JOURNAL OF IMMUNOLOGY LA English DT Article ID TRANSCRIPTION FACTOR FOXP3; DENDRITIC CELLS; TGF-BETA; IMMUNE REGULATION; SMALL-INTESTINE; RETINOIC-ACID; CD4(+); SUPPRESSION; GENERATION; RECEPTORS AB Surviving an infection requires the generation of an immune response that controls the invading pathogen while limiting collateral damage to self tissues that may result from an exuberant immune response. Various populations of regulatory cells, including Foxp3(+) Treg, have been shown to play a central role in the establishment of these controlled immune responses. In this review, I discuss current hypotheses and points of polemic associated with the origin, mode of action and antigen specificity of Foxp3(+) Treg during infection. C1 NIAID, Mucosal Immunol Unit, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA. RP Belkaid, Y (reprint author), NIAID, Mucosal Immunol Unit, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA. EM ybelkaid@niaid.nih.gov FU Division of Intramural Research; National Institute of Allergy and Infectious Diseases; National Institutes of Health FX This work was supported by the Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health. We would like to thank David B. Chow for the confocal image. We apologize to those authors whose work we were unable to cite because of space limitations. NR 35 TC 61 Z9 62 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0014-2980 J9 EUR J IMMUNOL JI Eur. J. Immunol. PD APR PY 2008 VL 38 IS 4 BP 918 EP 921 DI 10.1002/eji.200738120 PG 4 WC Immunology SC Immunology GA 293SV UT WOS:000255355900033 PM 18395860 ER PT J AU Gupta, A Mishra, P Kashaw, SK Jatav, V Stables, JP AF Gupta, Arun Mishra, Pradeep Kashaw, Sushil K. Jatav, Varsha Stables, J. P. TI Synthesis and anticonvulsant activity of some novel 3-aryl amino/amino-4-aryl-5-imino-Delta(2)-1,2,4-thiadiazoline SO EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article DE thiadiazoline; anticonvulsant; neurotoxicity ID EPILEPSY; DRUGS AB A series of 3-aryl amino/amino-4-aryl-5-imino-Delta(2)-1,2,4-thiadiazoline have been synthesized using an appropriate synthetic route and characterized by elemental analyses and spectral data. The anticonvulsant activity of all the synthesized compounds was evaluated against maximal electroshock induced seizures (MES) and subcutaneous pentylenetetrazole (ScPTZ) induced seizure models in mice. The neurotoxicity was assessed using the rotorod method. All the test compounds were administered at doses of 30, 100, and 300 mg/kg body weight and the anticonvulsant activity was noted at 0.5 and 4 h time intervals after the drug administration. Some of the compounds were evaluated for the Phenobarbitone induced hypnosis potentiation test. Among the compounds tested, all except 2h showed protection from MES seizures, whereas only 3b was found to be active in the ScPTZ test. Published by Elsevier Ltd. C1 [Gupta, Arun; Mishra, Pradeep; Kashaw, Sushil K.; Jatav, Varsha] Dr Hari Singh Gour Vishwavidyalaya, Pharmaceut Chem Div, Dept Pharmaceut Sci, Sagar 470003, MP, India. [Stables, J. P.] NIH, Preclin Pharmacol Sect, Epilepsy Branch, Bethesda, MD 20892 USA. RP Kashaw, SK (reprint author), Dr Hari Singh Gour Vishwavidyalaya, Pharmaceut Chem Div, Dept Pharmaceut Sci, Sagar 470003, MP, India. EM sushitkashaw@gmail.com NR 9 TC 10 Z9 10 U1 0 U2 0 PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER PI PARIS PA 23 RUE LINOIS, 75724 PARIS, FRANCE SN 0223-5234 J9 EUR J MED CHEM JI Eur. J. Med. Chem. PD APR PY 2008 VL 43 IS 4 BP 749 EP 754 DI 10.1016/j.ejmech.2007.05.008 PG 6 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 298YY UT WOS:000255724200007 PM 17624632 ER PT J AU Perjesi, P Das, U De Clercq, E Balzarini, J Kawase, M Sakagami, H Stables, JP Lorand, T Rozmer, Z Dimmock, JR AF Perjesi, Pal Das, Umashankar De Clercq, Erik Balzarini, Jan Kawase, Masame Sakagami, Hiroshi Stables, James P. Lorand, Tamas Rozmer, Zsuzsanna Dimmock, Jonathan R. TI Design, synthesis and antiproliferative activity of some 3-benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells SO EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article DE 3-benzylidene-4-chromanones; alpha,beta-unsaturated ketones; molecular modelling; cytotoxicity; murine toxicity ID MANNICH-BASES; 2-ARYLIDENEBENZOCYCLOALKANONES; 3-BENZYLIDENECHROMAN-4-ONES; TETRALONES; CHALCONES; INDANONES AB A series of 3-benzylidene-4-chromanones 1a-1 were prepared and their cytotoxicity towards human Molt 4/C8 and CEM T-lymphocytes as well as murine L1210 lymphoid leukemia cells were compared to the previously generated biodata in these three assays for the isosteric 2-benzylidene- 1-tetralones 2a-1. Over 40% of the compounds in series 1 were more potent than their counterparts in series 2, while equipotency was noted in one-third of the comparisons made. In general the IC(50) values of 1a-1 towards the human T-lymphocytes were in the low micromolar range. Molecular modelling revealed differences in shapes of representative molecules in series 1 and 2 which may contribute to the variation in cytotoxic potencies. Most of the compounds in series 1 displayed greater potencies towards HSC-2, HSC-3, HSC-4 and HL-60 neoplasms than HGF, HPC, and HPLF normal cells and were well tolerated in mice. (c) 2007 Elsevier Masson SAS. All rights reserved. C1 [Perjesi, Pal; Rozmer, Zsuzsanna] Univ Pecs, Inst Pharmaceut Sci, H-7602 Pecs, Hungary. [Das, Umashankar; Dimmock, Jonathan R.] Univ Saskatchewan, Coll Pharm & Nutr, Saskatoon, SK S7N 5C9, Canada. [De Clercq, Erik; Balzarini, Jan] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium. [Kawase, Masame] Matsuyama Univ, Fac Pharmaceut Sci, Matsuyama, Ehime 7908578, Japan. [Sakagami, Hiroshi] Meikai Univ, Sch Dent, Dept Diagnost & Therapeut Sci, Saitama 3500283, Japan. [Stables, James P.] NINDS, Rockville, MD 20852 USA. [Lorand, Tamas] Univ Pecs, Inst Med Chem & Biochem, H-7602 Pecs, Hungary. RP Perjesi, P (reprint author), Univ Pecs, Inst Pharmaceut Sci, POB 99, H-7602 Pecs, Hungary. EM pal.perjesi@aok.pte.hu; jr.dimmock@usask.ca FU Canadian Institutes of Health Research [53171] NR 23 TC 31 Z9 35 U1 0 U2 9 PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER PI PARIS PA 23 RUE LINOIS, 75724 PARIS, FRANCE SN 0223-5234 J9 EUR J MED CHEM JI Eur. J. Med. Chem. PD APR PY 2008 VL 43 IS 4 BP 839 EP 845 DI 10.1016/j.ejmech.2007.06.017 PG 7 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 298YY UT WOS:000255724200017 PM 17692998 ER PT J AU Kapogiannis, D Campion, P Grafman, J Wassermann, EM AF Kapogiannis, Dimitrios Campion, Paul Grafman, Jordan Wassermann, Eric M. TI Reward-related activity in the human motor cortex SO EUROPEAN JOURNAL OF NEUROSCIENCE LA English DT Article DE motor cortex; reward; stimulation; VTA ID TRANSCRANIAL MAGNETIC STIMULATION; MEDIAL PREFRONTAL CORTEX; CORTICAL EXCITABILITY; CEREBRAL-CORTEX; INTRACORTICAL INHIBITION; FUNCTIONAL MRI; ORBITOFRONTAL CORTEX; PARKINSONS-DISEASE; PREDICTION ERRORS; DOPAMINE NEURONS AB The human primary motor cortex (M1) participates in motor learning and response selection, functions that rely on feedback on the success of behavior (i.e. reward). To investigate the possibility that behavioral contingencies alter M1 activity in humans, we tested intracortical inhibition with single and paired (subthreshold/suprathreshold) transcranial magnetic stimulation during a slot machine simulation that delivered variable money rewards for three-way matches and required no movement. A two-way match before the third barrel had stopped (increased reward expectation) was associated with more paired-pulse inhibition than no match. Receiving a large reward on the preceding trial augmented this effect. A control task that manipulated attention to the same stimuli produced no changes in excitability. The origin of this reward-related activity is not clear, although dopaminergic ventral tegmental area neurons project to M1, where they are thought to inhibit output neurons and could be the source of the finding. Transcranial magnetic stimulation of M1 may be useful as a quantitative measure of reward-related activity. C1 [Kapogiannis, Dimitrios; Campion, Paul; Wassermann, Eric M.] NINDS, NIH, Brain Stimulat Unit, Bethesda, MD 20892 USA. [Grafman, Jordan] NINDS, NIH, Cognit Neurosci Sect, Bethesda, MD 20892 USA. RP Wassermann, EM (reprint author), NINDS, NIH, Brain Stimulat Unit, MSC 1440,10 Ctr Dr, Bethesda, MD 20892 USA. EM wassermanne@ninds.nih.gov OI Grafman, Jordan H./0000-0001-8645-4457; Campion, Paul/0000-0002-9569-5321 FU Intramural NIH HHS NR 92 TC 32 Z9 33 U1 2 U2 2 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0953-816X J9 EUR J NEUROSCI JI Eur. J. Neurosci. PD APR PY 2008 VL 27 IS 7 BP 1836 EP 1842 DI 10.1111/j.1460-9568.2008.06147.x PG 7 WC Neurosciences SC Neurosciences & Neurology GA 282HX UT WOS:000254559600025 PM 18371077 ER PT J AU Hansson, AC Rimondini, R Neznanova, O Sommer, WH Heilig, M AF Hansson, Anita C. Rimondini, Roberto Neznanova, Olga Sommer, Wolfgang H. Heilig, Markus TI Neuroplasticity in brain reward circuitry following a history of ethanol dependence SO EUROPEAN JOURNAL OF NEUROSCIENCE LA English DT Article DE animal model; extended amygdala; immediate early genes; in-situ hybridization; mitogen-activated protein kinase; rat ID SIGNAL-REGULATED KINASE; C-FOS EXPRESSION; CORTICOTROPIN-RELEASING-FACTOR; MEDIAL PREFRONTAL CORTEX; RAT-BRAIN; NUCLEUS-ACCUMBENS; EXTENDED AMYGDALA; PROTEIN-KINASES; MESSENGER-RNA; TRANSCRIPTIONAL REGULATION AB Mitogen-activated and extracellular regulated kinase (MEK) and extracellular signal-regulated protein kinase (ERK) pathways may underlie ethanol-induced neuroplasticity. Here, we used the MEK inhibitor 1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene (UO126) to probe the role of MEK/ERK signaling for the cellular response to an acute ethanol challenge in rats with or without a history of ethanol dependence. Ethanol (1.5 g/kg, i.p.) induced expression of the marker genes c-fos and egr-1 in brain regions associated with both rewarding and stressful ethanol actions. Under non-dependent conditions, ethanol-induced c-fos expression was generally not affected by MEK inhibition, with the exception of the medial amygdala (MeA). In contrast, following a history of dependence, a markedly suppressed c-fos response to acute ethanol was found in the medial pre-frontal/orbitofrontal cortex (OFC), nucleus accumbens shell (AcbSh) and paraventricular nucleus (PVN). The suppressed ethanol response in the OFC and AcbSh, key regions involved in ethanol preference and seeking, was restored by pre-treatment with UO126, demonstrating a recruitment of an ERK/MEK-mediated inhibitory regulation in the post-dependent state. Conversely, in brain areas involved in stress responses (MeA and PVN), an MEK/ERK-mediated cellular activation by acute ethanol was lost following a history of dependence. These data reveal region-specific neuroadaptations encompassing the MEK/ERK pathway in ethanol dependence. Recruitment of MEK/ERK-mediated suppression of the ethanol response in the OFC and AcbSh may reflect devaluation of ethanol as a reinforcer, whereas loss of an MEK/ERK-mediated response in the MeA and PVN may reflect tolerance to its aversive actions. These two neuroadaptations could act in concert to facilitate progression into ethanol dependence. C1 [Hansson, Anita C.; Neznanova, Olga; Sommer, Wolfgang H.; Heilig, Markus] NIAAA, Lab Clin & Translat Studies, NIH, Bethesda, MD 20892 USA. [Rimondini, Roberto] Univ Bologna, Dept Pharmacol, Bologna, Italy. RP Hansson, AC (reprint author), NIAAA, Lab Clin & Translat Studies, NIH, 10 Ctr Dr,10-1-5330, Bethesda, MD 20892 USA. EM anita.hansson@mail.nih.gov RI Rimondini, Roberto/B-2500-2010; OI Rimondini, Roberto/0000-0003-4099-513X; Heilig, Markus/0000-0003-2706-2482; Sommer, Wolfgang/0000-0002-5903-6521 FU Intramural NIH HHS [, NIH0012006624]; PHS HHS [NIH0012006624] NR 70 TC 48 Z9 48 U1 0 U2 2 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0953-816X J9 EUR J NEUROSCI JI Eur. J. Neurosci. PD APR PY 2008 VL 27 IS 8 BP 1912 EP 1922 DI 10.1111/j.1460-9568.2008.06159.x PG 11 WC Neurosciences SC Neurosciences & Neurology GA 287WS UT WOS:000254947900003 PM 18412612 ER PT J AU Schubert, M Beck, S Taube, W Amtage, F Faist, M Gruber, M AF Schubert, M. Beck, S. Taube, W. Amtage, F. Faist, M. Gruber, M. TI Balance training and ballistic strength training are associated with task-specific corticospinal adaptations SO EUROPEAN JOURNAL OF NEUROSCIENCE LA English DT Article DE human; plasticity; posture; TMS; training ID TRANSCRANIAL MAGNETIC STIMULATION; EVOKED MOTOR-RESPONSES; HUMAN SKELETAL-MUSCLE; PRESYNAPTIC INHIBITION; H-REFLEX; FORCE DEVELOPMENT; HUMAN GAIT; BIMANUAL COORDINATION; NEURAL ADAPTATION; BRAIN-STIMULATION AB The aim of this study was to investigate the role of presumably direct corticospinal pathways in long-term training of the lower limb in humans. It was hypothesized that corticospinal projections are affected in a training-specific manner. To assess specificity, balance training was compared to training of explosive strength of the shank muscles and to a nontraining group. Both trainings comprised 16 1-h sessions within 4 weeks. Before and after training, the maximum rate of force development was monitored to display changes in motor performance. Neurophysiological assessment was performed during rest and two active tasks, each of which was similar to one type of training. Hence, both training groups were tested in a trained and a nontrained task. H-reflexes in soleus (SOL) muscle were tested in order to detect changes at the spinal level. Corticospinal adaptations were assessed by colliding subthreshold transcranial magnetic stimulation to condition the SOL H-reflex. The short-latency facilitation of the conditioned H-reflex was diminished in the trained task and enhanced in the nontrained task. This was observable in the active state only. On a functional level, training increased the rate of force development suggesting that corticospinal projections play a role in adaptation of leg motor control. In conclusion, long-term training of shank muscles affected fast corticospinal projections. The significant interaction of task and training indicates context specificity of training effects. The findings suggest reduced motor cortical influence during the trained task but involvement of direct corticospinal control for new leg motor tasks in humans. C1 [Schubert, M.] Univ Hosp Balgrist, Spinal Cord Injury Ctr, Zurich, Switzerland. [Schubert, M.; Amtage, F.; Faist, M.] Univ Freiburg, Dept Clin Neurol & Neurophysiol, D-7800 Freiburg, Germany. [Taube, W.] Univ Freiburg, Dept Sport Sci, D-7800 Freiburg, Germany. [Beck, S.] NINDS, Human Motor Control Sect, Natl Inst Hlth, Bethesda, MD 20892 USA. RP Schubert, M (reprint author), Univ Hosp Balgrist, Spinal Cord Injury Ctr, Zurich, Switzerland. EM martin.schubert@balgrist.ch RI Taube, Wolfgang/E-4018-2012 OI Taube, Wolfgang/0000-0002-8802-2065 NR 56 TC 47 Z9 47 U1 1 U2 15 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0953-816X J9 EUR J NEUROSCI JI Eur. J. Neurosci. PD APR PY 2008 VL 27 IS 8 BP 2007 EP 2018 DI 10.1111/j.1460-9568.2008.06186.x PG 12 WC Neurosciences SC Neurosciences & Neurology GA 287WS UT WOS:000254947900013 PM 18412622 ER PT J AU Ashwell, M Lambert, JP Alles, MS Branca, F Bucchini, L Brzozowska, A de Groot, LCPGM Dhonukshe-Rutten, RAM Dwyer, JT Fairweather-Tait, S Koletzko, B Pavlovic, M Raats, MM Serra-Majem, L Smith, R van Ommen, B Van't Veer, P von Rosen, J Pijls, LTJ AF Ashwell, Margaret Lambert, Janet P. Alles, Martine S. Branca, Francesco Bucchini, Luca Brzozowska, Anna de Groot, Lisette C. P. G. M. Dhonukshe-Rutten, Rosalie A. M. Dwyer, Johanna T. Fairweather-Tait, Sue Koletzko, Berthold Pavlovic, Mirjana Raats, Monique M. Serra-Majem, Lluis Smith, Rhonda van Ommen, Ben van't Veer, Pieter von Rosen, Julia Pijls, Loek T. J. CA EURRECA Network TI How we will produce the evidence-based EURRECA toolkit to support nutrition and food policy SO EUROPEAN JOURNAL OF NUTRITION LA English DT Article DE EURRECA; Network of Excellence; micronutrients; nutrient recommendations; nutrient requirements; food policy; nutrition policy; health; EURRECA toolkit; harmonisation ID EUROPE; RECOMMENDATIONS; VALUES; ENERGY AB Background There is considerable variation in the recommended micronutrient intakes used by countries within Europe, partly due to different methodologies and concepts used to determine requirements and different approaches used to express the recommendations. As populations become more mobile and multinational, and more traditional foods become available internationally, harmonised recommendations based on up to date science are needed. This was recognised by the European Commission's (EC) Directorate-General (DG) Research in their 2005 call for proposals for a Network of Excellence (NoE) on 'nutrient status and requirements of specific vulnerable population groups'. EURopean micronutrient RECommendations Aligned (EURRECA), which has 34 partners representing 17 European countries, started on its 5-year EC-funded programme in January 2007. The programme of work was developed over 2 years prior to submitting an application to the EC. The Network's first integrating Meeting (IM) held in Lisbon in April 2007, and subsequent consultations, has allowed further refinement of the programme. Aim This paper presents the rationale for the EURRECA Network's roadmap, which starts by establishing the status quo for devising micronutrient recommendations. The Network has the opportunity to identify previous barriers and then explore 'evidence-based' solutions that have not been available before to the traditional panels of experts. The network aims to produce the EURRECA 'toolkit' to help address and, in some cases, overcome these barriers so that it can be used by those developing recommendations. Results The status quo has been largely determined by two recent initiatives; the Dietary Reference Intake (DRI) reports from the USA and Canada and suggestions for approaches to international harmonisation of nutrient-based dietary standards from the United Nations University (UNU). In Europe, the European Food Safety Authority (EFSA) has been asked by the EC's Directorate-General for Health and Consumer Protection to produce values for micronutrient recommendations. Therefore, EURRECA will draw on the uniqueness of its consortium to produce the sustainable EURRECA toolkit, which will help make such a task more effective and efficient. Part of this uniqueness is the involvement in EURRECA of small and medium-sized enterprises (SMEs), consumer organisations, nutrition societies and other stakeholders as well as many scientific experts. The EURRECA toolkit will contain harmonised best practice guidance for a more robust science base for setting micronutrient recommendations. Hence, in the future, the evidence base for deriving nutrient recommendations will have greater breadth and depth and will be more transparent. Conclusions The EURRECA Network will contribute to the broader field of food and nutrition policy by encouraging and enabling the alignment of nutrient recommendations. It will do this through the development of a scientific toolkit by its partners and other stakeholders across Europe. This will facilitate and improve the formulation of micronutrient recommendations, based on transparently evaluated and quantified scientific evidence. The Network aims to be sustainable beyond its EC funding period. C1 [von Rosen, Julia] Europe Aisbl, ILSI, B-1200 Brussels, Belgium. [Ashwell, Margaret] Ashwell Associates Europe Ltd, Ashwell SG7 5PZ, Herts, England. [Lambert, Janet P.] Lambert Nutr Consultancy Ltd, Watlington OX49 5JS, Oxon, England. [Alles, Martine S.] Numico Res BV, NL-6700 EV Wageningen, Netherlands. [Branca, Francesco] WHO, Reg Off Europe, DK-2100 Copenhagen, Denmark. [Bucchini, Luca] Hylobates Consulting Srl, I-00135 Rome, Italy. [Brzozowska, Anna] Agr Univ Warsaw, SGGW, Dept Human Nutr, PL-02766 Warsaw, Poland. [de Groot, Lisette C. P. G. M.; Dhonukshe-Rutten, Rosalie A. M.; van't Veer, Pieter] Univ Wageningen & Res Ctr, Div Human Nutr, NL-6700 EV Wageningen, Netherlands. [Dwyer, Johanna T.] NIH, Bethesda, MD 20892 USA. [Fairweather-Tait, Sue] Univ E Anglia, Sch Med Hlth Policy & Practice, Diet & Hlth Grp, Norwich NR4 7TJ, Norfolk, England. [Koletzko, Berthold; von Rosen, Julia] Univ Munich, Dr Von Hauner Childrens Hosp, Div Metab Dis & Nutr Med, D-80337 Munich, Germany. [Pavlovic, Mirjana] Univ Belgrade, Inst Med Res, Dept Nutr & Metab, Belgrade 11000, Serbia. [Raats, Monique M.] Univ Surrey, Dept Food Consumer Behav & Hlth, Guildford GU2 7XH, Surrey, England. [Serra-Majem, Lluis] Univ Las Palmas Gran Canaria, Las Palmas Gran Canaria, Spain. [Smith, Rhonda] Minerva Publ Relat & Commun Ltd, Monxton SP11 8AR, Hants, England. [van Ommen, Ben] TNO, Nutr & Food Res Inst, NL-3700 AJ Zeist, Netherlands. RP Pijls, LTJ (reprint author), Europe Aisbl, ILSI, Avenue E Mounier 83,Box 6, B-1200 Brussels, Belgium. RI Raats, Monique/G-5348-2012; Fairweather-Tait, Susan/K-4251-2012; OI Raats, Monique/0000-0002-8057-2783; Dhonukshe-Rutten, Rosalie/0000-0002-9736-1034; Dwyer, Johanna/0000-0002-0783-1769; de Groot, Lisette /0000-0003-2778-2789; Serra-Majem, Lluis/0000-0002-9658-9061 NR 31 TC 40 Z9 40 U1 1 U2 12 PU DR DIETRICH STEINKOPFF VERLAG PI DARMSTADT PA PO BOX 10 04 62, D-64204 DARMSTADT, GERMANY SN 1436-6207 J9 EUR J NUTR JI Eur. J. Nutr. PD APR PY 2008 VL 47 SU 1 BP 2 EP 16 DI 10.1007/s00394-008-1002-6 PG 15 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 296OC UT WOS:000255554700002 PM 18427857 ER PT J AU Hou, SJ Kovac, P AF Hou, Shujie Kovac, Pavol TI A convenient synthesis of furanose-free D-fucose per-O-acetates and a precursor for anthrose SO EUROPEAN JOURNAL OF ORGANIC CHEMISTRY LA English DT Article DE latent anthrose donor; acetolysis; carbohydrates; synthetic methods; deoxygenation ID BACILLUS-ANTHRACIS EXOSPORIUM; TETRASACCHARIDE SIDE-CHAIN; MAJOR GLYCOPROTEIN; GLYCOSIDES; OLIGOSACCHARIDE; DERIVATIVES; VACCINE; BCLA AB Methyl 3,4-O-isopropylidene-alpha- or beta-D-galactopyranoside was iodinated with triiodoimidazole in the presence of triphenylphosphane and the corresponding 6-deoxy-6-iodo derivatives 5 or 6, respectively, were converted to furanose-free 1,2,3,4 -tetra-O-acetyl-alpha,beta-D-fucopyranose. A key intermediate for chemical synthesis of anthrose, a constituent of the tetrasaccharide of major glycoprotein of Bacillus anthracis exosporium, 1-O-acetyl-4-azido-2-O-benzoyl-3-O-benzyl-4,6-dideoxy-alpha,beta-D-glucopyranose, was synthesized from 5 or 6 in 7 steps. The latter was readily converted into the corresponding 1-O-trichloroacetimidate. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008). C1 [Hou, Shujie; Kovac, Pavol] NIH, LBC, Bethesda, MD 20892 USA. RP Kovac, P (reprint author), NIH, LBC, 8 Ctr Dr, Bethesda, MD 20892 USA. EM houshu@niddk.nih.gov; kpn@helix.nih.gov NR 28 TC 10 Z9 10 U1 0 U2 7 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1434-193X J9 EUR J ORG CHEM JI Eur. J. Org. Chem. PD APR PY 2008 IS 11 BP 1947 EP 1952 DI 10.1002/ejoc.200701173 PG 6 WC Chemistry, Organic SC Chemistry GA 290TC UT WOS:000255144100012 ER PT J AU Elkashef, AM Anderson, A Li, SH Kahn, R Ciraulo, D Reid, M Roache, J Urschel, H Somoza, E Salloum, I AF Elkashef, A. M. Anderson, A. Li, S. H. Kahn, R. Ciraulo, D. Reid, M. Roache, J. Urschel, H. Somoza, E. Salloum, I. TI Modafinil for cocaine addiction: Multi-site clinical trial SO EUROPEAN PSYCHIATRY LA English DT Meeting Abstract C1 [Elkashef, A. M.; Anderson, A.; Li, S. H.; Kahn, R.] NIDA, Dpmc, NIH, Bethesda, MD USA. [Ciraulo, D.] Boston Univ, Dept Psychiat, Boston, MA 02215 USA. [Reid, M.] NYU, Dept Psychiat, New York, NY 10016 USA. [Roache, J.] START Ctr, Dept Psychiat, San Antonio, TX USA. [Urschel, H.] Res Across Amer, Dept Psychiat, Dallas, TX USA. [Somoza, E.] Cincinnati ARC, Dept Psychiat, Cincinnati, OH USA. [Salloum, I.] Univ Pittsburgh, Western Psychiat Inst & Clin, Dept Psychiat, Pittsburgh, PA 15213 USA. NR 0 TC 1 Z9 1 U1 0 U2 7 PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER PI PARIS PA 23 RUE LINOIS, 75724 PARIS, FRANCE SN 0924-9338 J9 EUR PSYCHIAT JI Eur. Psychiat. PD APR PY 2008 VL 23 SU 2 BP S307 EP S308 DI 10.1016/j.eurpsy.2008.01.1056 PG 2 WC Psychiatry SC Psychiatry GA 288LL UT WOS:000254987801331 ER PT J AU Gorelick, DA AF Gorelick, D. A. TI Symposium: Treatment of cocaine dependence : The state of the science SO EUROPEAN PSYCHIATRY LA English DT Meeting Abstract C1 [Gorelick, D. A.] Natl Inst Drug Abuse, Intramural Res Program, Natl Inst Hlth, Baltimore, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER PI PARIS PA 23 RUE LINOIS, 75724 PARIS, FRANCE SN 0924-9338 J9 EUR PSYCHIAT JI Eur. Psychiat. PD APR PY 2008 VL 23 SU 2 BP S16 EP S16 DI 10.1016/j.eurpsy.2008.01.058 PG 1 WC Psychiatry SC Psychiatry GA 288LL UT WOS:000254987800056 ER PT J AU Schulze, TG AF Schulze, T. G. TI Doing research in the USA: Chances and challenges for young European psychiatrists SO EUROPEAN PSYCHIATRY LA English DT Meeting Abstract C1 [Schulze, T. G.] US Govt, Dept Hlth & Human Serv, NIMH, NIH,Unit Genet Basis Mood & Anxiety Disorders, Bethesda, MD USA. [Schulze, T. G.] Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, D-6800 Mannheim, Germany. RI Schulze, Thomas/H-2157-2013 NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER PI PARIS PA 23 RUE LINOIS, 75724 PARIS, FRANCE SN 0924-9338 J9 EUR PSYCHIAT JI Eur. Psychiat. PD APR PY 2008 VL 23 SU 2 BP S33 EP S34 DI 10.1016/j.eurpsy.2008.01.123 PG 2 WC Psychiatry SC Psychiatry GA 288LL UT WOS:000254987800121 ER PT J AU Saha, RN Dudek, SM AF Saha, Ramendra N. Dudek, Serena M. TI Action potentials: To the nucleus and beyond SO EXPERIMENTAL BIOLOGY AND MEDICINE LA English DT Review DE action potentials; Ca2+; synaptic plasticity; LTP; LTD ID LONG-TERM POTENTIATION; TIMING-DEPENDENT PLASTICITY; REGULATED KINASE ACTIVATION; SYNAPTIC PLASTICITY; LATE-PHASE; HIPPOCAMPAL-NEURONS; GENE-EXPRESSION; NMDA-RECEPTORS; CA2+ CHANNELS; TRANSCRIPTION FACTORS AB The neuronal nucleus is now widely accepted as playing a vital role in maintaining long-term changes in synaptic effectiveness. To act, however, the nucleus must be appropriately relayed with information regarding the latest round of synaptic plasticity. Several constraints of doing so in a neuron pertain to the often significant spatial distance of synapses from the nucleus and the number of synapses required for such a signal to reach functional levels in the nucleus. Largely based on the sensitivity of transcriptional responses to NMDA receptor antagonists, it has been postulated that the signals are physically relayed by biochemical messengers from the synapse to the nucleus. Alternatively, a second, less often considered but equally viable method of signal transduction may be initiated by action potentials generated proximal to the nucleus, wherefrom the signal can be relayed directly by calcium or indirectly by biochemical second messengers. We consider action potential-dependent signaling to the nucleus to have its own computational advantages over the synapse-to-nucleus signal for some functions. This minireview summarizes the logic and experimental support for these two modes of signaling and attempts to validate the action potential model as playing an important role in transcriptional regulation relating specifically to long-term synaptic plasticity. C1 [Saha, Ramendra N.; Dudek, Serena M.] NIEHS, Synapt & Dev Plast Grp, Neurobiol Lab, NIH, Res Triangle Pk, NC 27709 USA. RP Dudek, SM (reprint author), NIEHS, Synapt & Dev Plast Grp, Neurobiol Lab, NIH, 111 Alexander Dr, Res Triangle Pk, NC 27709 USA. EM dudek@niehs.nih.gov RI Saha, Ramendra/C-7000-2014; OI Saha, Ramendra/0000-0002-5494-2584; Dudek, Serena M./0000-0003-4094-8368 FU Intramural NIH HHS NR 68 TC 15 Z9 16 U1 0 U2 3 PU SOC EXPERIMENTAL BIOLOGY MEDICINE PI MAYWOOD PA 195 WEST SPRING VALLEY AVE, MAYWOOD, NJ 07607-1727 USA SN 1535-3702 J9 EXP BIOL MED JI Exp. Biol. Med. PD APR PY 2008 VL 233 IS 4 BP 385 EP 393 DI 10.3181/0709-MR-241 PG 9 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 281EF UT WOS:000254479000002 PM 18367626 ER PT J AU Rota, G Veit, R Nardo, D Weiskopf, N Birbaumer, N Dogil, G AF Rota, Giuseppina Veit, Ralf Nardo, Davide Weiskopf, Nikolaus Birbaumer, Niels Dogil, Grzegorz TI Processing of inconsistent emotional information: an fMRI study SO EXPERIMENTAL BRAIN RESEARCH LA English DT Article DE emotional prosody; anterior cingulate cortex; language processing; functional magnetic resonance imaging ID ANTERIOR CINGULATE CORTEX; HUMAN FRONTAL-LOBE; PREFRONTAL CORTEX; INTERFERENCE TASK; COUNTING STROOP; WORKING-MEMORY; FUNCTIONAL MRI; LATERALIZATION; PROSODY; REGIONS AB Previous studies investigating the anterior cingulate cortex (ACC) have relied on a number of tasks which involved cognitive control and attentional demands. In this fMRI study, we tested the model that ACC functions as an attentional network in the processing of language. We employed a paradigm that requires the processing of concurrent linguistic information predicting that the cognitive costs imposed by competing trials would engender the activation of ACC. Subjects were confronted with sentences where the semantic content conflicted with the prosodic intonation (CONF condition) randomly interspaced with sentences which conveyed coherent discourse components (NOCONF condition). We observed the activation of the rostral ACC and the middle frontal gyrus when the NOCONF condition was subtracted from the CONF condition. Our findings provide evidence for the involvement of the rostral ACC in the processing of complex competing linguistic stimuli, supporting theories that claim its relevance as a part of the cortical attentional circuit. The processing of emotional prosody involved a bilateral network encompassing the superior and medial temporal cortices. This evidence confirms previous research investigating the neuronal network that supports the processing of emotional information. C1 [Rota, Giuseppina; Dogil, Grzegorz] Univ Stuttgart, Inst Nat Language Proc, D-70174 Stuttgart, Germany. [Rota, Giuseppina; Veit, Ralf; Nardo, Davide; Weiskopf, Nikolaus; Birbaumer, Niels] Univ Tubingen, Inst Med Psychol & Behav Neurobiol, Tubingen, Germany. [Veit, Ralf] Max Planck Inst Biol Cybernet, Tubingen, Germany. [Nardo, Davide] Univ Rome, Dept Psychol, Rome, Italy. [Weiskopf, Nikolaus] UCL, Inst Neurol, Wellcome Trust Ctr Neuroimaging, London, England. [Birbaumer, Niels] NINDS, NIH, Human Cort Physiol Sect, Bethesda, MD 20892 USA. RP Rota, G (reprint author), Univ Stuttgart, Inst Nat Language Proc, Azenbergstr 12, D-70174 Stuttgart, Germany. EM giuseppina.rota@uni-tuebingen.de RI Weiskopf, Nikolaus/B-9357-2008; Veit, Ralf/F-8907-2012; Nardo, Davide/G-7345-2015 OI Weiskopf, Nikolaus/0000-0001-5239-1881; Veit, Ralf/0000-0001-9860-642X; Nardo, Davide/0000-0002-8158-5738 NR 41 TC 7 Z9 7 U1 1 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0014-4819 J9 EXP BRAIN RES JI Exp. Brain Res. PD APR PY 2008 VL 186 IS 3 BP 401 EP 407 DI 10.1007/s00221-007-1242-3 PG 7 WC Neurosciences SC Neurosciences & Neurology GA 277XT UT WOS:000254248700006 PM 18094962 ER PT J AU Ajiro, K Bortner, CD Westmoreland, J Cidlowski, JA AF Ajiro, Kozo Bortner, Carl D. Westmoreland, Jim Cidlowski, John A. TI An endogenous calcium-dependent, caspase-independent intranuclear degradation pathway in thymocyte nuclei: Antagonism by physiological concentrations of K+ ions SO EXPERIMENTAL CELL RESEARCH LA English DT Article DE apoptosis; nuclease; CaCl2; DNA fragmentation; histone H2B ID SERINE-PROTEASE INHIBITORS; APOPTOTIC RAT THYMOCYTES; PROGRAMMED CELL-DEATH; DNA FRAGMENTATION; HISTONE H2B; CHROMATIN CONDENSATION; ACTIVATION; ENDONUCLEASE; PHOSPHORYLATION; IDENTIFICATION AB Calcium ions have been implicated in apoptosis for many years, however the precise role of this ion in the cell death process remains incomplete. We have extensively examined the role of Ca2+ on nuclear degradation in vitro using highly purified nuclei isolated from non-apoptotic rat thymocytes. We show that these nuclei are devoid of CAD (caspase-activated DNase), and DNA degradation occurs independent of caspase activity. Serine proteases rather than caspase-3 appear necessary for this Ca2+-dependent DNA degradation in nuclei. We analyzed nuclei treated with various concentrations of Ca2+ in the presence of both a physiological (140 mM) and apoptotic (40 mM) concentration of KCl. Our results show that a 5-fold increase in Ca2+ is required to induce DNA degradation at the physiological KCl concentration compared to the lower, apoptotic concentration of the cation. Ca2+-induced internucleosomal DNA degradation was also accompanied by the release of histories, however the apoptotic-specific phosphorylation of histone H2B does not occur in these isolated nuclei. Interestingly, physiological concentrations of K+ inhibit both Ca2+-dependent DNA degradation and histone release suggesting that a reduction of intracellular K+ is necessary for this apoptosis-associated nuclear degradation in cells. Together, these data define an inherent caspase-independent catabolic pathway in thymocyte nuclei that is sensitive to physiological concentrations of intracellular cations. Published by Elsevier Inc. C1 [Cidlowski, John A.] NIEHS, NIH, Lab Signal Transduct, Res Triangle Pk, NC 27709 USA. NIEHS, NIH, Mol Genet Lab, Res Triangle Pk, NC 27709 USA. RP Cidlowski, JA (reprint author), NIEHS, NIH, Lab Signal Transduct, 111 TW Alexander Dr,POB 12233 MD E2-02, Res Triangle Pk, NC 27709 USA. EM cidlows1@niehs.nih.gov FU Intramural NIH HHS [Z01 ES090079-12] NR 47 TC 13 Z9 13 U1 0 U2 1 PU ELSEVIER INC PI SAN DIEGO PA 525 B STREET, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0014-4827 J9 EXP CELL RES JI Exp. Cell Res. PD APR 1 PY 2008 VL 314 IS 6 BP 1237 EP 1249 DI 10.1016/j.yexcr.2007.12.028 PG 13 WC Oncology; Cell Biology SC Oncology; Cell Biology GA 283BX UT WOS:000254612700005 PM 18294629 ER PT J AU Elliot, S Catanuto, P Fernandez, P Espinosa-Heidmann, D Karl, M Korach, K Cousins, SW AF Elliot, Sharon Catanuto, Paola Fernandez, Pedro Espinosa-Heidmann, Diego Karl, Michael Korach, Kenneth Cousins, Scott W. TI Subtype specific estrogen receptor action protects against changes in MMP-2 activation in mouse retinal pigmented epithelial cells SO EXPERIMENTAL EYE RESEARCH LA English DT Article DE estrogen receptor; age related macular degeneration; extracellular matrix; estrogen; matrix metalloproteinases; tissue inhibitors of metalloproteinases ID FINGER TRANSCRIPTION FACTORS; NONLETHAL OXIDANT INJURY; MATRIX METALLOPROTEINASE-2; MESANGIAL CELLS; ER-ALPHA; IN-VIVO; MACULAR DEGENERATION; EXTRACELLULAR-MATRIX; BREAST-CANCER; EXPRESSION AB Eyes with age-related macular degeneration (AMD) demonstrate accumulation of specific deposits and extracellular matrix (ECM) molecules under the retinal pigment epithelium (RPE). AMD is about two times more prevalent in aging postmenopausal women. Therefore we studied whether 17 beta-estradiol (E-2) modulates the expression and activity of the trimolecular complex (MMP-2, TIMP-2 and MMP-14), molecules which are of major importance for ECM turnover in RPE. We used cell lines isolated from estrogen receptor knockout mice (ERKO) to determine which ER (estrogen receptor) subtype was important for ECM regulation in RPE cells. We found that mouse RPE sheets had higher baseline MMP-2 activity in the presence of ER beta. This correlated with higher MMP-2 activity in RPE cell lines isolated from ERKO alpha. mice. Exposure to E-2 increased MMP-2 activity in mouse RPE cell lines, In addition E-2 increased transcriptional activation of the MMP-2 promoter through a functional Sp1 site which required the presence of ER beta, but not ER alpha. E-2 also maintained levels of pro MMP-2, and MMP-14 and TIMP-2 activity after oxidant injury. Since the direct effects of E-2 on MMP-2 transcriptional activation and the regulation of the trimolecular complex after oxidant-induced injury requires ER beta, this receptor subtype may have a role as a potential therapeutic target to prevent changes in activation of MMP-2. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Elliot, Sharon; Catanuto, Paola; Fernandez, Pedro; Espinosa-Heidmann, Diego; Karl, Michael] Univ Miami, Miller Sch Med, Lab Sex & Gender Differences Hlth & Dis, Miami, FL 33136 USA. [Korach, Kenneth] Natl Inst Environm Hlth Sci, Receptor Biol Lab, Res Triangle Pk, NC 27709 USA. [Cousins, Scott W.] Duke Univ, Ctr Eye, Duke Ctr Mascula Dis, Durham, NC USA. RP Elliot, S (reprint author), Univ Miami, Miller Sch Med, Lab Sex & Gender Differences Hlth & Dis, Rosensteil Med Bldg Room 1043,R104, Miami, FL 33136 USA. EM selliot@med.miami.edu OI Korach, Kenneth/0000-0002-7765-418X FU NEI NIH HHS [R01 EY014477, R01 EY014477-03, R01 EY14477-04, P30 EY005722, P30 EY005722-22, R01 EY014477-01A1, R01 EY014477-04, R01 EY014477-02] NR 47 TC 14 Z9 15 U1 1 U2 2 PU ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0014-4835 J9 EXP EYE RES JI Exp. Eye Res. PD APR PY 2008 VL 86 IS 4 BP 653 EP 660 DI 10.1016/j.exer.2008.01.010 PG 8 WC Ophthalmology SC Ophthalmology GA 295DB UT WOS:000255454100012 PM 18313050 ER PT J AU Ross, RJ Zhou, M Shen, D Fariss, RN Ding, XY Bojanowski, CM Tuo, J Chan, CC AF Ross, Robert J. Zhou, Min Shen, Defen Fariss, Robert N. Ding, Xiaoyan Bojanowski, Christine M. Tuo, Jingsheng Chan, Chi-Chao TI Immunological protein expression profile in Ccl2/Cx3cr1 deficient mice with lesions similar to age-related macular degeneration SO EXPERIMENTAL EYE RESEARCH LA English DT Article DE age-related macular degeneration; animal model; chemokine; cytokine; complement factor; toll-like receptor 4; microglia; macrophage ID COMPLEMENT FACTOR-H; ENDOTOXIN-INDUCED UVEITIS; TOLL-LIKE RECEPTOR-4; VISUAL IMPAIRMENT; EPITHELIAL-CELLS; BRUCHS MEMBRANE; UNITED-STATES; VARIANT; SUSCEPTIBILITY; POLYMORPHISM AB Age-related macular degeneration (AMD) is the leading cause of blindness in the United States. Cel2 knock-out (KO) mice sporadically develop the cardinal features of AMD in their senescent stage. Humans bearing a loss of function variant or single nucleotide polymorphism (SNP) in CX3CR1 are at increased risk of developing AMD. We recently developed Ccl2(-/-)/Cx3cr(-/-) mice, which consistently develop retinal degeneration with many AMD features. Since there is strong evidence for an immunological role in AMD pathogenesis, we examined ocular immune protein expression levels in Ccl2(-/-)/Cx3cr1(-/-), Ccl2(-/-), Cx3crl(-/-), and age-matched wild-type (WT) mice. Immunohistochemistry revealed increased complement C3d in Bruch's membrane, retinal pigment epithelium (RPE), choroidal capillaries, and particularly drusen of the Ccl2(-/-) Cx3cr1(-/-) mice relative to the WT controls. No change was detected in single KO mice. Real-time RT-PCR revealed a 2.5-fold increase in C3 expression in the Ccl2(-/-)/Cx3cl(-/-). While the retinas of four month old WT and Ccl2(-/-) showed minimal immunoreactivity for markers of macrophages and microglia, infiltrates of these mononuclear phagocytic cells were detected in the Ccl2(-/-)/Cx3cr(-/-) retinal lesions and a few foci in the Cx3c1(-/-) retina. The Ccl2(-/-)/Cx3cr1(-/-) had reduced toll-like receptor 4 (TLR4) expression in the RPE. Following LPS injection, the Ccl2(-/-)/Cx3cr1(-/-) had significantly reduced endotoxin-induced uveitis scores and showed a diminished increase in Tlr4 mRNA expression. No changes in TLR4 expression were detected in either single KO. Autoantibodies against the retina and photoreceptors were also detected in the Ccl2(-/-) /Cx3cr1(-/-) serum. Real-time RT-PCR revealed significant increases in Ccl5 transcript in the Ccl2(-/-)/Cx3cr1(-/-) relative to the WT. These results suggest that innate immunity and possibly adaptive immunity play an important role in Ccl2(-/-)/Cx3cr1(-/-) retinal degeneration. Moreover, since human AMD patients show similar immunopathological profiles, these results support the Ccl2(-/-)/Cx3Cr1(-/-) as a suitable model for human AMD. Published by Elsevier Ltd. C1 [Ross, Robert J.; Zhou, Min; Shen, Defen; Ding, Xiaoyan; Bojanowski, Christine M.; Tuo, Jingsheng; Chan, Chi-Chao] NEI, NIH, Immunol Lab, Immunopathol Sect, Bethesda, MD 20892 USA. [Fariss, Robert N.] NICHHD, NIH, NEI, Bethesda, MD 20892 USA. [Ding, Xiaoyan] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou 510060, Guangdong, Peoples R China. RP Chan, CC (reprint author), NEI, NIH, Immunol Lab, Immunopathol Sect, 10 Ctr Dr Bldg 10,Room 10N103, Bethesda, MD 20892 USA. EM chanc@nei.nih.gov OI Tuo, Jingsheng/0000-0002-1372-7810 FU Intramural NIH HHS [Z01 EY000222-22, Z01 EY000418-04] NR 46 TC 46 Z9 49 U1 0 U2 7 PU ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0014-4835 J9 EXP EYE RES JI Exp. Eye Res. PD APR PY 2008 VL 86 IS 4 BP 675 EP 683 DI 10.1016/j.exer.2008.01.014 PG 9 WC Ophthalmology SC Ophthalmology GA 295DB UT WOS:000255454100015 PM 18308304 ER PT J AU Komatsu, T Chiba, T Yamaza, H Yamashita, K Shimada, A Hoshiyama, Y Henmi, T Ohtani, H Higami, Y de Cabo, R Ingram, DK Shimokawa, I AF Komatsu, Toshimitsu Chiba, Takuya Yamaza, Haruyoshi Yamashita, Kimihiro Shimada, Atsuyoshi Hoshiyama, Yasuyo Henmi, Tomoko Ohtani, Hiroshi Higami, Yoshikazu de Cabo, Rafael Ingram, Donald K. Shimokawa, Isao TI Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-accelerated mouse strain P8 SO EXPERIMENTAL GERONTOLOGY LA English DT Article DE calorie restriction; neurodegeneration; ketogenic diet; metabolism; oxidative stress ID KETOGENIC DIET; SAMP8 MOUSE; RESTRICTION; AGE; MICE; METABOLISM; DISEASE; BRAIN; RAT; AVOIDANCE AB Calorie restriction (CR) is an experimental intervention in laboratory animals that attenuates age-associated increases in morbidity, mortality, and functional impairment. It is characterized by mild ketosis, hypoinsulinemia and hypoglycemia. In this study, we examined whether metabolic simulation of CR by a diet of isocaloric ketogenic or hypoinsulinemic diets ameliorated the learning and memory deficit in a strain of senescence-accelerated prone mice (SAMP8), a mouse model of age-dependent impairments in learning and memory. Male SAMP8 mice were fed high carbohydrate (CHO), high fat (FAT), or high protein (PRO) diets after weaning, and calorie intake was adjusted to 95% (sub ad libitum, sAL) or 70% (CR) of the mean calorie intake of control mice. At 28 weeks of age, We found CR ameliorated the performance defects of SAMP8 mice in a passive avoidance task. Neither FAT nor PRO diets affected performance of the task when fed sAL level, although a diet of these compositions partially mimicked the serum parameters of CR mice. These results suggest restriction of calorie intake is important for the prevention of learning and memory deficits, and that the simulation of serum changes induced by CR is not sufficient to prevent the cognitive defects of SAMP8 mice. (C) 2008 Elsevier Inc. All rights reserved. C1 [Komatsu, Toshimitsu; Chiba, Takuya; Hoshiyama, Yasuyo; Henmi, Tomoko; Ohtani, Hiroshi; Shimokawa, Isao] Nagasaki Univ, Grad Sch Biomed Sci, Dept Investigat Pathol, Nagasaki 8528523, Japan. [Yamashita, Kimihiro] Nagasaki Univ, Fac Environm Studies, Dept Environm Conservat, Pharmacol Sect, Nagasaki 8528521, Japan. [Shimada, Atsuyoshi] Aichi Human Serv Ctr, Inst Dev Res, Dept Pathol, Kasugai, Aichi 4800392, Japan. [Higami, Yoshikazu] Tokyo Univ Sci, Fac Pharmaceut Sci, Drug Metab & Mol Pathol, Noda, Chiba 2788510, Japan. [de Cabo, Rafael; Ingram, Donald K.] NIA, Lab Expt Gerontol, Intramural Res Program, NIH, Baltimore, MD 21224 USA. [Ingram, Donald K.] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Nutrit Neurosci & Aging Lab, Baton Rouge, LA 70708 USA. RP Chiba, T (reprint author), Nagasaki Univ, Grad Sch Biomed Sci, Dept Investigat Pathol, 1-12-4 Sakamoto, Nagasaki 8528523, Japan. EM takuya@net.nagasaki-u.ac.jp RI de Cabo, Rafael/E-7996-2010; de Cabo, Rafael/J-5230-2016; OI de Cabo, Rafael/0000-0002-3354-2442; , rafael/0000-0003-2830-5693 FU Intramural NIH HHS NR 36 TC 32 Z9 33 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0531-5565 J9 EXP GERONTOL JI Exp. Gerontol. PD APR PY 2008 VL 43 IS 4 BP 339 EP 346 DI 10.1016/j.exger.2008.01.008 PG 8 WC Geriatrics & Gerontology SC Geriatrics & Gerontology GA 292KS UT WOS:000255265500010 PM 18316167 ER PT J AU Engels, EA AF Engels, Eric A. TI Inflammation in the development of lung cancer: epidemiological evidence SO EXPERT REVIEW OF ANTICANCER THERAPY LA English DT Review DE biomarker; HIV; immunity; immunodeficiency; infection; inflammation; lung cancer; tuberculosis ID C-REACTIVE PROTEIN; IDIOPATHIC PULMONARY-FIBROSIS; UNITED-STATES; INCREASED RISK; CHLAMYDIA-PNEUMONIAE; GENETIC-VARIANTS; NONSMOKING WOMEN; HIV-INFECTION; DISEASE; POLYMORPHISM AB The lung is a site for repeated or chronic inflammatory insults. Epidemiologic research has provided evidence to support the hypothesis that tissue damage caused by inflammation can initiate or promote the development of lung cancer, possibly in conjunction with tobacco use. For example, some studies suggest an increased risk of lung cancer among persons with lung infections, such as tuberculosis, bacterial pneumonia, or inflammatory lung diseases. Elevated serum levels of C-reactive protein, an inflammation marker, are associated with heightened lung cancer risk. Recent studies also demonstrate increased lung cancer risk among immunosuppressed individuals infected with HIV Other research indicates an association between genetic polymorphisms in the inflammation pathway, which might modulate the inflammatory response and lung cancer risk. C1 NCI, Div Canc Epidemiol & Genet, Infect & Immunoepidemiol Branch, Rockville, MD 20892 USA. RP Engels, EA (reprint author), NCI, Div Canc Epidemiol & Genet, Infect & Immunoepidemiol Branch, 6120 Execut Blvd,EPS 7076, Rockville, MD 20892 USA. EM engelse@exchange.nih.gov NR 55 TC 128 Z9 136 U1 1 U2 9 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1473-7140 J9 EXPERT REV ANTICANC JI Expert Rev. Anticancer Ther PD APR PY 2008 VL 8 IS 4 BP 605 EP 615 DI 10.1586/14737140.8.4.605 PG 11 WC Oncology SC Oncology GA 343EY UT WOS:000258836900011 PM 18402527 ER PT J AU Lodish, MB Stratakis, CA AF Lodish, Maya B. Stratakis, Constantine A. TI RET oncogene in MEN2, MEN2B, MTC and other forms of thyroid cancer SO EXPERT REVIEW OF ANTICANCER THERAPY LA English DT Review DE clinical trial; multiple endocrine neoplasia; oncogene; thyroid cancer; tyrosine kinase inhibitor ID RECEPTOR TYROSINE KINASE; NEOPLASIA TYPE 2A; PHASE-II TRIAL; NEUROENDOCRINE TUMORS; PROGNOSTIC-FACTORS; PROPHYLACTIC THYROIDECTOMY; CLINICAL-CHARACTERISTICS; TRANSFORMING GENE; MEDULLARY; CARCINOMA AB Hereditary medullary thyroid carcinoma (MTC) is caused by specific autosomal dominant gain-of-function mutations in the RET proto-oncogene. Genotype-phenotype correlations exist that help predict the presence of other associated endocrine neoplasms as well as the timing of thyroid cancer development. MTC represents a promising model for targeted cancer therapy, as the oncogenic event responsible for initiating malignancy has been well characterized. The RET proto-oncogene has become the target for molecularly designed drug therapy. Tyrosine kinase inhibitors targeting activated RET are currently in clinical trials for the treatment of patients with MTC. This review will provide a brief overview of MTC and the associated RET oncogenic mutations, and will summarize the therapies designed to strategically interfere with the pathologic activation of the RET oncogene. C1 [Lodish, Maya B.] CRC, Pediat Endocrinol & Sect Endocrinol & Genet, Program Dev Endocrinol & Genet, Bethesda, MD 20892 USA. [Stratakis, Constantine A.] NICHHD, NIH, Sect Endocrinol & Genet, Pediat Endocrinol Inter Inst Training Fellowship, Bethesda, MD 20892 USA. [Stratakis, Constantine A.] NICHHD, NIH, Program Dev Endocrinol & Genet, Bethesda, MD 20892 USA. RP Lodish, MB (reprint author), CRC, Pediat Endocrinol & Sect Endocrinol & Genet, Program Dev Endocrinol & Genet, Bldg 10,Room 1-3330,10 Ctr Dr,MSC1103, Bethesda, MD 20892 USA. EM lodishma@mail.nih.gov FU Intramural NIH HHS [Z99 HD999999]; NICHD NIH HHS [Z01 HD000642] NR 67 TC 44 Z9 49 U1 0 U2 1 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1473-7140 J9 EXPERT REV ANTICANC JI Expert Rev. Anticancer Ther PD APR PY 2008 VL 8 IS 4 BP 625 EP 632 DI 10.1586/14737140.8.4.625 PG 8 WC Oncology SC Oncology GA 343EY UT WOS:000258836900013 PM 18402529 ER PT J AU Veenstra, TD Marcus, K AF Veenstra, Timothy D. Marcus, Katrin TI Multidimensional advancement of neuroproteomics SO EXPERT REVIEW OF PROTEOMICS LA English DT Editorial Material ID DEMENTIA C1 [Marcus, Katrin] Ruhr Univ Bochum, Funct Prote Med Proteom Ctr, D-44780 Bochum, Germany. [Veenstra, Timothy D.] NCI, SAIC Frederick Inc, Adv Technol Program, Lab Prote & Analyt Technol, Frederick, MD 21701 USA. RP Marcus, K (reprint author), Ruhr Univ Bochum, Funct Prote Med Proteom Ctr, Univ Str 150, D-44780 Bochum, Germany. EM veenstra@ncifcrf.gov; katrin.marcus@rub.de NR 3 TC 4 Z9 4 U1 0 U2 0 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1478-9450 J9 EXPERT REV PROTEOMIC JI Expert Rev. Proteomics PD APR PY 2008 VL 5 IS 2 BP 149 EP 151 DI 10.1586/14789450.5.2.149 PG 3 WC Biochemical Research Methods SC Biochemistry & Molecular Biology GA 313KV UT WOS:000256740400001 PM 18466109 ER PT J AU Prieto, DA Ye, XY Veenstra, TD AF Prieto, DaRue A. Ye, Xiaoying Veenstra, Timothy D. TI Proteomic analysis of traumatic brain injury: the search for biomarkers SO EXPERT REVIEW OF PROTEOMICS LA English DT Review DE biomarker discovery; biomarkers; diagnosis; plasma and serum; proteomics; traumatic brain injury; validation ID HUMAN CEREBROSPINAL-FLUID; CONTROLLED CORTICAL IMPACT; MILD HEAD-INJURY; MASS-SPECTROMETRY; PLASMA-PROTEINS; SERUM S-100B; IDENTIFICATION; SPECT; NEUROPROTEOMICS; STROKE AB Iraq and Afghanistan has brought this disorder to the attention of the global community. A biomarker that would enable army medics to rapidly diagnose the severity of TBI on the battlefield would be a huge asset. Unfortunately, the study of TBI has not historically attracted the proteomic research community's interest as other disorders have, such as cancer. On the positive side, however, many of the analytical and technological challenges that were overcome in the development of biofluid proteomic methods are now being applied to the study of TBI. In this review, we discuss and highlight select examples of discovery-driven proteomic studies focused on finding effective biomarkers for TBI. C1 [Prieto, DaRue A.; Ye, Xiaoying; Veenstra, Timothy D.] NCI, SAIC Frederick Inc, Adv Technol Program, Lab Prote & Analyt Technol, Frederick, MD 21702 USA. RP Veenstra, TD (reprint author), NCI, SAIC Frederick Inc, Adv Technol Program, Lab Prote & Analyt Technol, Frederick, MD 21702 USA. EM veenstra@ncifcrf.gov FU NCI NIH HHS [N01-CO-12400] NR 38 TC 12 Z9 14 U1 1 U2 4 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1478-9450 J9 EXPERT REV PROTEOMIC JI Expert Rev. Proteomics PD APR PY 2008 VL 5 IS 2 BP 283 EP 291 DI 10.1586/14789450.5.2.283 PG 9 WC Biochemical Research Methods SC Biochemistry & Molecular Biology GA 313KV UT WOS:000256740400012 PM 18466057 ER PT J AU Bratter, JL King, RB AF Bratter, Jenifer L. King, Rosalind B. TI "But Will It Last?": Marital instability among interracial and same-race couples SO FAMILY RELATIONS LA English DT Article DE divorce; family; interracial marriages; marital dissolution; race ID UNITED-STATES; MATE SELECTION; MARRIAGE; BLACK; DISRUPTION; STABILITY; DIVORCE; WHITE; COHABITATION; WOMEN AB The literature on interracial families has examined social stigmas attached to interracial relationships but has not thoroughly documented whether crossing racial boundaries increases the risk of divorce. Using the 2002 National Survey of Family Growth (Cycle VI), we compare the likelihood of divorce for interracial couples to that of same-race couples. Comparisons across marriage cohorts reveal that, overall, interracial couples have higher rates of divorce, particularly for those marrying during the late-1980s. We also find race and gender variation. Compared to White/White couples, White female/Black male, and White female/Asian male marriages were more prone to divorce; meanwhile, those involving non-White females and White males and Hispanics and non-Hispanic persons had similar or lower risks of divorce. C1 [Bratter, Jenifer L.] Rice Univ, Dept Sociol, Houston, TX 77005 USA. [King, Rosalind B.] NICHHD, Demograph & Behav Sci Branch, Populat Res Ctr, Bethesda, MD 20892 USA. RP Bratter, JL (reprint author), Rice Univ, Dept Sociol, POB 1892-MS 28,6100 Main St, Houston, TX 77005 USA. EM jlb1@rice.edu; kingros@mail.nih.gov NR 56 TC 65 Z9 65 U1 4 U2 26 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0197-6664 J9 FAM RELAT JI Fam. Relat. PD APR PY 2008 VL 57 IS 2 BP 160 EP 171 DI 10.1111/j.1741-3729.2008.00491.x PG 12 WC Family Studies; Social Work SC Family Studies; Social Work GA 282IC UT WOS:000254560100005 ER PT J AU Yamaguchi, Y Passeron, T Hoashi, T Watabe, H Rouzaud, F Yasumoto, K Hara, T Tohyama, C Katayama, I Miki, T Hearing, VJ AF Yamaguchi, Yuji Passeron, Thierry Hoashi, Toshihiko Watabe, Hidenori Rouzaud, Franocois Yasumoto, Ken-ichi Hara, Takahiko Tohyama, Chiharu Katayama, Ichiro Miki, Toru Hearing, Vincent J. TI Dickkopf 1 (DKK1) regulates skin pigmentation and thickness by affecting Wnt/beta-catenin signaling in keratinocytes SO FASEB JOURNAL LA English DT Article DE keratin 9; epithelial cell transforming sequence 2; protease-activated receptor 2; glucose synthase kinase; melanocyte ID PROTEINASE-ACTIVATED RECEPTOR-2; MESENCHYMAL-EPITHELIAL INTERACTIONS; EXPOSING BONE-MARROW; ADULT STEM-CELLS; PALMOPLANTAR FIBROBLASTS; GENE-EXPRESSION; WNT; DIFFERENTIATION; PATHWAY; PHOSPHORYLATION AB The epidermis (containing primarily keratinocytes and melanocytes) overlies the dermis (containing primarily fibroblasts) of human skin. We previously reported that dickkopf 1 (DKK1) secreted by fibroblasts in the dermis elicits the hypopigmented phenotype of palmoplantar skin due to suppression of melanocyte function and growth via the regulation of two important signaling factors, microphthalmia-associated transcription factor (MITF) and beta-catenin. We now report that treatment of keratinocytes with DKK1 increases their proliferation and decreases their uptake of melanin and that treatment of reconstructed skin with DKK1 induces a thicker and less pigmented epidermis. DNA microarray analysis revealed many genes regulated by DKK1, and several with critical expression patterns were validated by reverse transcriptase-polymerase chain reaction and Western blotting. DKK1 induced the expression of keratin 9 and a-Kelch-like ECT2 interacting protein (alpha KLEIP) but down-regulated the expression of beta-catenin, glycogen synthase kinase 3(3, protein kinase C, and proteinase-activated receptor-2 (PAR-2), which is consistent with the expression patterns of those proteins in human palmoplantar skin. Treatment of reconstructed skin with DKK1 reproduced the expression patterns of those key proteins observed in palmoplantar skin. These findings further elucidate why human skin is thicker and paler on the palms and soles than on the trunk through topographical and site-specific differences in the secretion of DKK1 by dermal fibroblasts that affects the overlying epidermis. C1 [Yamaguchi, Yuji] Nagoya City Univ, Grad Sch Med Sci, Dept Geriatr & Environm Dermatol, Mizuho Ku, Nagoya, Aichi 4678601, Japan. [Yamaguchi, Yuji; Passeron, Thierry; Hoashi, Toshihiko; Watabe, Hidenori; Rouzaud, Franocois; Yasumoto, Ken-ichi; Hara, Takahiko; Miki, Toru; Hearing, Vincent J.] NCI, Cell Biol Lab, NIH, Bethesda, MD 20892 USA. [Yamaguchi, Yuji; Tohyama, Chiharu; Katayama, Ichiro] Osaka Univ, Grad Sch Med, Dept Dermatol, Osaka, Japan. RP Yamaguchi, Y (reprint author), Nagoya City Univ, Grad Sch Med Sci, Dept Geriatr & Environm Dermatol, Mizuho Ku, 1 Kawasumi,Mizuho Cho, Nagoya, Aichi 4678601, Japan. EM jaijin@med.nagoya-cu.ac RI Yamaguchi, Yuji/B-9312-2008 FU Intramural NIH HHS NR 53 TC 65 Z9 68 U1 1 U2 7 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 IS 4 BP 1009 EP 1020 DI 10.1096/fj.07-9475com PG 12 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 282PZ UT WOS:000254581000007 PM 17984176 ER PT J AU Bousquet, M Saint-Pierre, M Julien, C Salem, N Cicchetti, F Calon, F AF Bousquet, M. Saint-Pierre, M. Julien, C. Salem, N., Jr. Cicchetti, F. Calon, F. TI Beneficial effects of dietary omega-3 polyunsaturated fatty acid on toxin-induced neuronal degeneration in an animal model of Parkinson's disease SO FASEB JOURNAL LA English DT Article DE MPTP; neuroprotection; DHA; dopamine ID DOCOSAHEXAENOIC ACID; DOPAMINE TRANSPORTER; ALZHEIMERS-DISEASE; OXIDATIVE STRESS; MOUSE MODEL; TYROSINE-HYDROXYLASE; MONOAMINERGIC NEUROTRANSMISSION; INDUCED DYSKINESIAS; SUBSTANTIA-NIGRA; LEARNING-ABILITY AB In this study, we examined whether omega-3 (n-3) polyunsaturated fatty acids (PUFAs) may exert neuroprotective action in Parkinson's disease, as previously shown in Alzheimer's disease. We exposed mice to either a control or a high n-3 PUFA diet from 2 to 12 months of age and then treated them with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; 140 mg/kg in 5 days). High n-3 PUFA dietary consumption completely prevented the MPTP-induced decrease of tyrosine hydroxylase (TH)-labeled nigral cells (P<0.01 vs. MPTP mice on control diet), Nurr1 mRNA (P<0.01 vs. MPTP mice on control diet), and dopamine transporter mRNA levels (P<0.05 vs. MPTP mice on control diet) in the substantia nigra. Although n-3 PUFA dietary treatment had no effect on striatal dopaminergic terminals, the high n-3 PUFA diet protected against the MPTP-induced decrease in dopamine (P<0.05 vs. MPTP mice on control diet) and its metabolite dihydroxyphenylacetic acid (P<0.05 vs. MPTP mice on control diet) in the striatum. Taken together, these data suggest that a high n-3 PUFA dietary intake exerts neuroprotective actions in an animal model of Parkinsonism. C1 [Bousquet, M.; Julien, C.; Calon, F.] CHUQ, CHU Laval, Ctr Res Endocrinol Mol & Oncol, Quebec City, PQ G1V 4G2, Canada. [Saint-Pierre, M.; Cicchetti, F.] CHUQ, CHU Laval, Ctr Res Neurosci, Quebec City, PQ, Canada. [Bousquet, M.; Julien, C.; Calon, F.] Univ Laval, Fac Pharm, Quebec City, PQ, Canada. [Cicchetti, F.] Univ Laval, Dept Med, Quebec City, PQ G1K 7P4, Canada. [Salem, N., Jr.] NIAAA, Sect Nutr Neurosci, Lab Membrane Biochem & Biophys, Div Intramural Clin & Biol Res, Rockville, MD 20852 USA. RP Calon, F (reprint author), CHUQ, CHU Laval, Res Ctr, T2-05,2705 Blvd Laurier, Quebec City, PQ G1V 4G2, Canada. EM francesca.cicchetti@crchul.ulaval.ca; frederic.calon@crchul.ulaval.ca NR 89 TC 106 Z9 111 U1 6 U2 15 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 IS 4 BP 1213 EP 1225 DI 10.1096/fj.07-9677com PG 13 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 282PZ UT WOS:000254581000026 PM 18032633 ER PT J AU Abdala, APL Rybak, IA Smith, JC Paton, JFR AF Abdala, Ana Paula Lima Rybak, Ilya A. Smith, Jeffrey C. Paton, Julian F. R. TI Thinking outside the BotC (Botzinger complex): possible brainstem origins of abdominal (AB) expiratory activity in the rat in situ SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Abdala, Ana Paula Lima; Paton, Julian F. R.] Univ Bristol, Dept Physiol & Pharmacol, Bristol Heart Inst, Bristol, Avon, England. [Rybak, Ilya A.] Drexel Univ, Coll Med, Dept Neurobiol & Anat, Philadelphia, PA 19104 USA. [Smith, Jeffrey C.] NINDS, Cellular & Syst Neurobiol Sect, Neural Control Lab, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467805764 ER PT J AU Achat-Mendes, C Platt, DM Spealman, RD Newman, AH AF Achat-Mendes, Cindy Platt, Donna M. Spealman, Roger D. Newman, Amy H. TI Modulation of the Reinforcing and Discriminative Stimulus Effects of Cocaine by the Dopamine D3 Receptor Partial Agonist CJB 090 [N-(4-(4-(2,3-DichlorophenyBpiperazin-4(pyridine-2-yl)benzamide] in Squirrel Monkeys SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Achat-Mendes, Cindy; Platt, Donna M.; Spealman, Roger D.] Harvard Univ, Sch Med, NEPRC, Southborough, MA 01772 USA. [Newman, Amy H.] NIDA, IRP, Baltimore, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801223 ER PT J AU Anderson, AL Sahyoun, NR Tylavsky, FA Goodpaster, BH Lee, JS Sellmeyer, DE Houston, DK Harris, TB AF Anderson, Amy L. Sahyoun, Nadine R. Tylavsky, Frances A. Goodpaster, Bret H. Lee, Jung Sun Sellmeyer, Deborah E. Houston, Denise K. Harris, Tamara B. TI Dietary patterns and body fat distribution in older adults SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Anderson, Amy L.; Sahyoun, Nadine R.] Univ Maryland, Dept Nutr & Food Sci, College Pk, MD 20742 USA. [Tylavsky, Frances A.] Univ Tennessee, Memphis, TN USA. [Goodpaster, Bret H.] Univ Pittsburgh, Pittsburgh, PA USA. [Lee, Jung Sun] Univ Georgia, Athens, GA 30602 USA. [Sellmeyer, Deborah E.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Houston, Denise K.] Wake Forest Univ, Winston Salem, NC 27109 USA. [Harris, Tamara B.] NIH, Bethesda, MD 20892 USA. RI Sahyoun, Nadine/G-2608-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806071 ER PT J AU Anderson, SK Li, HC Sharma, N Wright, PW Woll, P Kaufman, D AF Anderson, Stephen Kent Li, Hongchuan Sharma, Neeraj Wright, Paul W. Woll, Petter Kaufman, Dan TI Are the KIR genes actively silenced prior to their tissue-specific activation? A KIR intronic promoter produces spliced antisense transcripts in human ES cells SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Anderson, Stephen Kent; Li, Hongchuan; Wright, Paul W.] NCI, Lab Expt Immunol, SAIC Frederick Inc, Frederick, MD 21701 USA. [Sharma, Neeraj] NCI, Canc & Inflammat Program, CCR, Frederick, MD 21701 USA. [Woll, Petter; Kaufman, Dan] Univ Minnesota, Stem Cell Inst, Minneapolis, MN USA. [Woll, Petter; Kaufman, Dan] Univ Minnesota, Dept Med, Minneapolis, MN 55455 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806322 ER PT J AU Andersson, J Tran, D Shevach, EM AF Andersson, John Tran, Dat Shevach, Ethan M. TI CD4+FoxP3+regulatory T cells confer infectious tolerance in a TGF-beta dependent manner SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Andersson, John; Tran, Dat; Shevach, Ethan M.] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801403 ER PT J AU Andrews, K Roseland, J Zhao, CW Schweitzer, A Holden, JM Perry, C Dwyer, J Picciano, MF Fisher, K Saldanha, L Yetley, E Douglass, L AF Andrews, Karen Roseland, Janet Zhao, Cuiwei Schweitzer, Amy Holden, Joanne M. Perry, Charles Dwyer, Johanna Picciano, Mary Frances Fisher, Kenneth Saldanha, Leila Yetley, Elizabeth Douglass, Larry TI Commonly reported US adult multivitamin/mineral (MVM) products: analysis of labeled vs. analytical values for 19 vitamins and minerals SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Andrews, Karen; Roseland, Janet; Zhao, Cuiwei; Schweitzer, Amy; Holden, Joanne M.] USDA ARS, BHNRC NDL, Beltsville, MD USA. [Perry, Charles] NASS, Fairfax, VA USA. [Dwyer, Johanna; Picciano, Mary Frances; Fisher, Kenneth; Saldanha, Leila; Yetley, Elizabeth] NIH ODS, Rockville, MD USA. [Douglass, Larry] Univ Maryland, Beltsville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467807819 ER PT J AU Ansari, HR Teng, BY Nadeem, A Schnermann, J Mustafa, SJ AF Ansari, Habib R. Teng, Bunyen Nadeem, Ahmed Schnermann, J. Mustafa, S. Jamal TI A1 adenosine receptor-activated protein kinase C signaling in A1 knock-out mice coronary artery smooth muscle cells SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Ansari, Habib R.; Teng, Bunyen; Nadeem, Ahmed; Mustafa, S. Jamal] W Virginia Univ, Ctr Interdisciplinary Res Cardiovasc Sci, Morgantown, WV 26506 USA. [Schnermann, J.] NIDDK, NIH, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806722 ER PT J AU Bagattin, A Hugendubler, L Hayes, S Mueller, E AF Bagattin, Alessia Hugendubler, Lynne Hayes, Schantel Mueller, Elisabetta TI Conditional knock-down of the transcriptional coactivator PGC-1 alpha in mice using Cre-LoxP induced RNA interference SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Bagattin, Alessia; Hugendubler, Lynne; Hayes, Schantel; Mueller, Elisabetta] NIDDK, NIH, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467804606 ER PT J AU Bailey, RL Miller, PE Hartman, TJ Mitchell, DC Smiciklas-Wright, H AF Bailey, Regan Lucas Miller, Paige E. Hartman, Terryl J. Mitchell, Diane C. Smiciklas-Wright, Helen TI Assessment of the effects of dietary supplement use (DSU) on Estimated Average Requirement (EAR) and Adequate Intake (AI) in older adults SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Bailey, Regan Lucas] NIH, Off Dietary Supplements, Bethesda, MD 20892 USA. [Miller, Paige E.; Hartman, Terryl J.; Mitchell, Diane C.; Smiciklas-Wright, Helen] Penn State Univ, University Pk, PA 16802 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467803816 ER PT J AU Bansal, G Xie, ZH Rao, S Nocka, K Druey, K AF Bansal, Geetanjali Xie, Zhihui Rao, Sudhir Nocka, Karl Druey, Kirk TI Suppression of IgE-mediated allergic responses by Rgs13 SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Bansal, Geetanjali; Xie, Zhihui; Druey, Kirk] NIAID, NIH, Bethesda, MD 20892 USA. [Rao, Sudhir] Merck Res Labs, Boston, MA USA. [Nocka, Karl] Wyeth Ayerst Res, Cambridge, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802134 ER PT J AU Bansal, G Rao, S Nocka, K Druey, K AF Bansal, Geetanjali Rao, Sudhir Nocka, Karl Druey, Kirk TI RGS13 restricts G-protein-coupled receptor-induced responses in mast cells SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Bansal, Geetanjali; Druey, Kirk] NIAID, NIH, Bethesda, MD 20892 USA. [Rao, Sudhir] Merck Res Labs, Boston, MA USA. [Nocka, Karl] Wyeth Res, Cambridge, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801450 ER PT J AU Barber, DL Antonelli, LR Feng, CG Sharpe, AH Freeman, GJ Sher, A AF Barber, Daniel L. Antonelli, Lis R. Feng, Carl G. Sharpe, Arlene H. Freeman, Gordon J. Sher, Alan TI PD-L1 interaction limits excessive Th1 effector function during Mycobacterium tuberculosis infection SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Barber, Daniel L.; Antonelli, Lis R.; Feng, Carl G.] NIAID, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA. [Sharpe, Arlene H.] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA. [Sharpe, Arlene H.] Brigham & Womens Hosp, Boston, MA 02115 USA. [Freeman, Gordon J.] Harvard Univ, Sch Med, Dept Med, Boston, MA USA. [Freeman, Gordon J.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MD USA. RI Antonelli, Lis/G-2907-2012 NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806008 ER PT J AU Batchu, N Pawa, J Zhang, YF Myers, P Clark, J Miller-Degraff, L Zeldin, DC Sinal, CJ Goralski, K Seubert, JM AF Batchu, Sri Nagarjun Pawa, Jasmine Zhang, Yunfang Myers, Page Clark, James Miller-Degraff, Laura Zeldin, Darryl C. Sinal, Christopher J. Goralski, Kerry Seubert, John M. TI Androgen Effects On Soluble Epoxide Hydrolase Expression And Cardioprotection SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Batchu, Sri Nagarjun; Pawa, Jasmine; Zhang, Yunfang; Seubert, John M.] Univ Alberta, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2N8, Canada. [Myers, Page; Clark, James; Miller-Degraff, Laura; Zeldin, Darryl C.] NIEHS, Div Intramural Res, Res Triangle Pk, NC 27709 USA. [Sinal, Christopher J.] Dalhousie Univ, Fac Med, Halifax, NS, Canada. [Goralski, Kerry] Dalhousie Univ, Fac Pharm, Halifax, NS, Canada. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467807768 ER PT J AU Batkai, S Mukhopadhyay, P Rajesh, M Csiszar, A Cravatt, BF Hasko, G Liaudet, L Ungvari, Z Pacher, P AF Batkai, Sandor Mukhopadhyay, Partha Rajesh, Mohanraj Csiszar, Anna Cravatt, Benjamin F. Hasko, George Liaudet, Lucas Ungvari, Zoltan Pacher, Pal TI Genetic deletion of fatty acid amide hydrolase is associated with anti-inflammatory cardiovascular phenotype in mice SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Batkai, Sandor; Mukhopadhyay, Partha; Rajesh, Mohanraj] NIAAA, LPS, NIH, Bethesda, MD 10595 USA. [Csiszar, Anna; Ungvari, Zoltan] New York Med Coll, Dept Physiol, Valhalla, NY USA. [Cravatt, Benjamin F.] Scripps Res, Dept Physiol Chem, La Jolla, CA 07103 USA. [Hasko, George] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Surg, Newark, NJ USA. [Liaudet, Lucas] Univ Lausanne Hosp, Dept Intens Care Med, Lausanne, Switzerland. RI Batkai, Sandor/H-7983-2014; Liaudet, Lucas/E-1322-2017 OI Liaudet, Lucas/0000-0003-2670-4930 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467809037 ER PT J AU Batkai, S Mukhopadhyay, P Pacher, P Kunos, G AF Batkai, Sandor Mukhopadhyay, Partha Pacher, Pal Kunos, George TI The role of the endocannabinoid system in cirrhotic cardiomyopathy SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Batkai, Sandor; Mukhopadhyay, Partha; Pacher, Pal; Kunos, George] NIAAA, LPS, NIH, Bethesda, MD USA. RI Batkai, Sandor/H-7983-2014 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467808786 ER PT J AU Beck, JC Ferruci, L Sun, K Linda, F Varadhan, R Walston, J Guralnik, J Semba, R AF Beck, Justine C. Ferruci, Luigi Sun, Kai Linda, Fried Varadhan, Ravi Walston, Jeremy Guralnik, Jack Semba, Richard TI Circulating oxidized low-density lipoproteins are associated with overweight, obesity, and low serum carotenoids in older community-dwelling women SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Beck, Justine C.; Sun, Kai; Linda, Fried; Varadhan, Ravi; Walston, Jeremy; Semba, Richard] Johns Hopkins Med Inst, Baltimore, MD 21205 USA. [Ferruci, Luigi] NIA, Longitudinal Studies Sect, Clin Res Branch, Baltimore, MD 21224 USA. [Guralnik, Jack] NIA, Demog & Biometry Branch, Baltimore, MD 21224 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467804013 ER PT J AU Bennett, MP Bergman, C Mitchell, DC AF Bennett, Michael P. Bergman, Christian Mitchell, Drake C. TI Modulation of GPCR Function by alpha-Tocopherol SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Bennett, Michael P.; Bergman, Christian; Mitchell, Drake C.] NIAAA, NIH, Rockville, MD 20852 USA. NR 0 TC 0 Z9 0 U1 0 U2 4 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802046 ER PT J AU Bergamaschi, C Valentin, A Jalah, R Rosati, M Kulkarni, V Alicea, C Patel, V Zhang, GM Kjeken, R Felber, BK Pavlakis, GN AF Bergamaschi, Cristina Valentin, Antonio Jalah, Rashmi Rosati, Margherita Kulkarni, Viraj Alicea, Candido Patel, Vainav Zhang, Gen-Mu Kjeken, Rune Felber, Barbara K. Pavlakis, George N. TI Improved expression and delivery of IL-15 DNA vectors in combination with IL-15 receptor alpha in mice and macaques provide a potent growth signal for NK and T cells SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Bergamaschi, Cristina; Valentin, Antonio; Jalah, Rashmi; Rosati, Margherita; Kulkarni, Viraj; Alicea, Candido; Patel, Vainav; Zhang, Gen-Mu; Felber, Barbara K.; Pavlakis, George N.] NCI, Ctr Canc Res, Frederick, MD 21701 USA. [Kjeken, Rune] Inovio Inc, San Diego, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700626 ER PT J AU Berger, AC Roche, PA AF Berger, Adam Craig Roche, Paul A. TI Cholesterol regulates the loading of foreign antigens onto MHC class II in dendritic cells SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Berger, Adam Craig; Roche, Paul A.] NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467807622 ER PT J AU Berglund, ED Li, CY Lynes, SE Ayala, JE Wasserman, DH AF Berglund, Eric D. Li, Candice Y. Lynes, Sara E. Ayala, Julio E. Wasserman, David H. TI FVB/N mice are hypersensitive to moderate insulin-induced hypoglycemia while 129X1 mice are completely insensitive SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Berglund, Eric D.; Li, Candice Y.; Lynes, Sara E.; Ayala, Julio E.; Wasserman, David H.] Vanderbilt Univ, Nashville, TN USA. [Ayala, Julio E.; Wasserman, David H.] NIH, Vanderbilt Mouse Metab Phenotyping Ctr, Nashville, TN USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467807013 ER PT J AU Bermudez-Millan, A Hromi-Fiedler, A Damio, G Segura-Perez, S Perez-Escamilla, R AF Bermudez-Millan, Angela Hromi-Fiedler, Amber Damio, Grace Segura-Perez, Sofia Perez-Escamilla, Rafael TI Food group intake patterns differ between low-income Puerto Ricans and Non-Puerto Rican pregnant Latinas SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Perez-Escamilla, Rafael] Univ Connecticut, Connecticut NIH EXPORT Ctr Excellence Eliminating, Storrs, CT USA. [Damio, Grace] Hispan Hlth Council, Ctr Women & Childrens Hlth, Hartford, CT USA. [Segura-Perez, Sofia] Hispan Hlth Council, Ctr Community Nutr, Hartford, CT USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802477 ER PT J AU Bhatia, S Hodes, RJ AF Bhatia, Sumeena Hodes, Richard J. TI Structural requirements of B7 ligands for regulation of Indoleamine 2,3-dioxygenase in dendritic cells SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Bhatia, Sumeena] NCI, Expt Immunol Branch, Bethesda, MD 20892 USA. [Hodes, Richard J.] NIA, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700356 ER PT J AU Biehl, JK Yamanaka, S Boheler, KR Russell, B AF Biehl, Jesse K. Yamanaka, Satoshi Boheler, Kenneth R. Russell, Brenda TI Microprojections regulate proliferation and activity of cardiomyocytes derived from mouse embryonic stem cells SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Biehl, Jesse K.; Russell, Brenda] Univ Illinois, Chicago, IL USA. [Yamanaka, Satoshi; Boheler, Kenneth R.] NIA, Cardiovasc Sci Lab, NIH, Baltimore, MD 21224 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467804619 ER PT J AU Biragyn, A Anderson, RL Olkhanud, PB AF Biragyn, Arya Anderson, Robin L. Olkhanud, Purevdorj B. TI Elucidation of the role of chemokine receptors in the control of lung metastasis of breast cancer cells. SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Biragyn, Arya; Olkhanud, Purevdorj B.] NIA, Immunotherapeut Unit, LI, Baltimore, MD 21224 USA. [Anderson, Robin L.] Peter MacCallum Canc Ctr, Canc Biol Lab, Melbourne, Vic, Australia. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806532 ER PT J AU Bobe, G Weinstein, SJ Albanes, D Hirvonen, T Ashby, J Taylor, PR Virtamo, J Stolzenberg, RZ AF Bobe, Gerd Weinstein, Stephanie J. Albanes, Demetrius Hirvonen, Tero Ashby, Jason Taylor, Phil R. Virtamo, Jarmo Stolzenberg, Rachael Z. TI Flavonoid intake and risk of pancreatic cancer in male smokers (Finland) SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Bobe, Gerd; Weinstein, Stephanie J.; Albanes, Demetrius; Stolzenberg, Rachael Z.] NCI, Nutr Epidemiol Branch, Rockville, MD USA. [Bobe, Gerd] NCI, Off Prevent Oncol, Rockville, MD USA. [Taylor, Phil R.] NCI, Genet Epidemiol Branch, Rockville, MD USA. [Hirvonen, Tero; Virtamo, Jarmo] Natl Publ Hlth Inst, Dept Hlth Promot & Chron Dis Prevent, Helsinki, Finland. [Ashby, Jason] Informat Management Serv Inc, Rockville, MD USA. RI Albanes, Demetrius/B-9749-2015 NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802881 ER PT J AU Bornemann, A Mittelbronn, M Sullivan, T Stewart, CL AF Bornemann, Antje Mittelbronn, Michel Sullivan, Teresa Stewart, Colin L. TI Myonuclear degeneration in LMNA null mice SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Bornemann, Antje] Univ Tubingen, Inst Brain Res, D-7400 Tubingen, Germany. [Mittelbronn, Michel] Univ Zurich, Zurich, Switzerland. [Sullivan, Teresa; Stewart, Colin L.] NCI, Frederick Canc Res & Dev Ctr, Frederick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806415 ER PT J AU Bowen, SE Difilippantonio, MJ Livak, F AF Bowen, Steven E. Difilippantonio, Michael J. Livak, Ferenc TI Timing of rearrangement of multiple T-cell receptor loci in individual thymocyte precursors SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Bowen, Steven E.; Livak, Ferenc] Univ Maryland, Sch Med, Baltimore, MD 21201 USA. [Difilippantonio, Michael J.] NCI, Sect Canc Genom, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700830 ER PT J AU Boyaka, PN Duverger, A Tang, WJ Leppla, SH AF Boyaka, Prosper N. Duverger, Alexandra Tang, Wei-Jen Leppla, Stephen H. TI An edema toxin-based sublingual vaccine promotes immunity against both anthrax toxin and yersinia pestis antigens SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Boyaka, Prosper N.; Duverger, Alexandra] OSU, Columbus, OH USA. [Tang, Wei-Jen] Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA. [Leppla, Stephen H.] NIAID, Lab Bacterial Dis, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467808425 ER PT J AU Bradbury, JA Carey, MA Seubert, JM Myers, P Rouse, C Edin, M DeGraff, LM Germolec, D Zeldin, DC AF Bradbury, J. Alyce Carey, Michelle A. Seubert, John M. Myers, Page Rouse, Clay Edin, Matt DeGraff, Laura M. Germolec, Dori Zeldin, Darryl C. TI Cardiac effects of pulmonary influenza A viral infection SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Bradbury, J. Alyce; Carey, Michelle A.; Myers, Page; Rouse, Clay; Edin, Matt; DeGraff, Laura M.; Germolec, Dori; Zeldin, Darryl C.] NIEHS, NIH, Res Triangle Pk, NC 27709 USA. [Seubert, John M.] Univ Alberta, Edmonton, AB, Canada. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800370 ER PT J AU Brauer, PR Stetler-Stevenson, WG Tran, LU Reedy, MV AF Brauer, Philip R. Stetler-Stevenson, William G. Lan Uyen Tran Reedy, Mark V. TI A MMP-independent role for TIMP-2 during cardiac neural crest cell migration SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Brauer, Philip R.; Lan Uyen Tran; Reedy, Mark V.] Creighton Univ, Omaha, NE 68178 USA. [Stetler-Stevenson, William G.] NCI, Bethesda, MD 20892 USA. RI Stetler-Stevenson, William/H-6956-2012 OI Stetler-Stevenson, William/0000-0002-5500-5808 NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800337 ER PT J AU Bubier, JA Sproule, TJ Foreman, O Spolski, R Shaffer, DJ Morse, HC Leonard, WJ Roopenian, DC AF Bubier, Jason A. Sproule, Thomas J. Foreman, Oded Spolski, Rosanne Shaffer, Daniel J. Morse, Herbert C. Leonard, Warren J. Roopenian, Derry C. TI IL-21 Receptor Signaling Is Essential for BXSB-Yaa SLE Pathogenesis SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Bubier, Jason A.; Sproule, Thomas J.; Foreman, Oded; Roopenian, Derry C.] Jackson Lab, Bar Harbor, ME 04609 USA. [Spolski, Rosanne; Leonard, Warren J.] NHLBI, Lab Mol Immunol, Bethesda, MD 20892 USA. [Shaffer, Daniel J.] Bar Harbor BioTechnol, Trenton, ME USA. [Morse, Herbert C.] NIAID, Lab Immunopathol, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467807512 ER PT J AU Buccafusca, R Venditti, C Kenyon, L Johanson, RA Golden, JA Coady, MJ Berry, GT AF Buccafusca, Roberto Venditti, Charles Kenyon, Lawrence Johanson, Roy A. Golden, Jeffrey A. Coady, Michael J. Berry, Gerard T. TI The neonatal brain mitochondrial ribosomal protein subunit 6 gene expression is normal in the lethal Smit1 knockout and independent of the rescue of the phenotype with prenatal myoinositol treatment SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Buccafusca, Roberto; Berry, Gerard T.] Childrens Hosp, Boston, MA 02115 USA. [Venditti, Charles] NIH, Bethesda, MD 20892 USA. [Kenyon, Lawrence; Johanson, Roy A.; Golden, Jeffrey A.] Thomas Jefferson Univ, Philadelphia, PA 19107 USA. [Coady, Michael J.] Univ Montreal, Montreal, PQ, Canada. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467809211 ER PT J AU Butts, CL Belyavskaya, E Sternberg, EM AF Butts, Cherie L. Belyavskaya, Elena Sternberg, Esther M. TI Progesterone polarization of dendritic cell function varies during the estrus cycle SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Butts, Cherie L.; Belyavskaya, Elena; Sternberg, Esther M.] NIH, Sect Neuroendocrine Immunol & Behav, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467804713 ER PT J AU Cao, HP Lin, R Ghosh, S Anderson, RA Urban, JF AF Cao, Heping Lin, Rui Ghosh, Sanjukta Anderson, Richard A. Urban, Joseph F., Jr. TI Production and characterization of ZFP36L1 antiserum against recombinant protein from Escherichia coli SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Cao, Heping; Anderson, Richard A.; Urban, Joseph F., Jr.] ARS, Diet Gen & Immunol Lab, Beltsville Human Nutr Res Ctr, USDA, Beltsville, MD USA. [Cao, Heping; Lin, Rui; Ghosh, Sanjukta] NIEHS, NIH, DHHS, Res Triangle Pk, NC 27709 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467803024 ER PT J AU Caragacianu, DL Rao, M Hussain, M Schrump, D AF Caragacianu, Diana L. Rao, Mahadev Hussain, Mustafa Schrump, David TI Functional analysis of BORIS in immortalized bronchioepithelial cells (BEAS) SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Caragacianu, Diana L.; Rao, Mahadev; Hussain, Mustafa; Schrump, David] NCI, Surg Branch, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700658 ER PT J AU Carlson, BA Xu, XM Lee, BJ Gladyshev, VN Hatfield, DL AF Carlson, Bradley A. Xu, Xue-Ming Lee, Byeong Jae Gladyshev, Vadim N. Hatfield, Dolph L. TI The adaptor for stress-related selenoprotein synthesis does not require aminoacylation for its maturation SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Carlson, Bradley A.; Xu, Xue-Ming; Hatfield, Dolph L.] NCI, LCP, CCR, NIH, Bethesda, MD 20892 USA. [Lee, Byeong Jae] Seoul Natl Univ, Sch Biol Sci, Seoul, South Korea. [Lee, Byeong Jae] Seoul Natl Univ, Inst Mol Biol & Genet, Seoul, South Korea. [Gladyshev, Vadim N.] Univ Nebraska, Dept Biochem, Lincoln, NE 68583 USA. RI Gladyshev, Vadim/A-9894-2013 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467804521 ER PT J AU Caspi, RR Rachitskaya, AV Horai, R Li, ZQ Luger, D Villasmil, R Nussenblatt, RB Hansen, AM AF Caspi, Rachel R. Rachitskaya, Aleksandra V. Horai, Reiko Li, Zhuqing Luger, Dror Villasmil, Rafael Nussenblatt, Robert B. Hansen, Anna M. TI NKT cells constitutively express IL-23 receptor and ROR gamma t, and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Rachitskaya, Aleksandra V.] NEI, Immunol Lab, HHMI NIH Res Scholars Program, Bethesda, MD 20892 USA. [Villasmil, Rafael] NEI, Flow Cytometry Core, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467804174 ER PT J AU Charron, CS Clevidence, BA Milner, JA Kramer, M Baer, DJ Albaugh, G Davis, CD Ross, SA Seifried, H Kim, YS Emenaker, N Novotny, JA AF Charron, Craig S. Clevidence, Beverly A. Milner, John A. Kramer, Matthew Baer, David J. Albaugh, George Davis, Cindy D. Ross, Sharon A. Seifried, Harold Kim, Young S. Emenaker, Nancy Novotny, Janet A. TI Effect of dietary allyl isothiocyanate from Brassica vegetables on serum glutathione S-transferase-alpha concentration SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Charron, Craig S.; Clevidence, Beverly A.; Baer, David J.; Albaugh, George; Novotny, Janet A.] USDA, Beltsville Human Nutr Res Ctr, Beltsville, MD 20705 USA. [Kramer, Matthew] USDA, Biometr Consulting Serv, Beltsville, MD USA. [Milner, John A.; Davis, Cindy D.; Ross, Sharon A.; Seifried, Harold; Kim, Young S.; Emenaker, Nancy] NCI, Canc Prevent Div, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 4 U2 4 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806330 ER PT J AU Chaturvedi, A Pierce, S AF Chaturvedi, Akanksha Pierce, Susan TI The B cell receptor governs the subcellular location of Toll-like receptor 9 leading to hyper-responses to DNA-containing antigens SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Chaturvedi, Akanksha; Pierce, Susan] NIH, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700684 ER PT J AU Chaudhary, K Batchu, N Das, D Suresh, M Graves, J Zeldin, DC Seubert, JM AF Chaudhary, Ketul Batchu, Nagarjun Das, Dipankar Suresh, Mavanur Graves, Joan Zeldin, Darryl C. Seubert, John M. TI B-type Natriuretic Peptide and EET Mediated Cardioprotection SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Chaudhary, Ketul; Batchu, Nagarjun; Das, Dipankar; Suresh, Mavanur; Seubert, John M.] Univ Alberta, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2N8, Canada. [Graves, Joan; Zeldin, Darryl C.] Natl Inst Environm Hlth Sci, Lab Resipatory Biol, Res Triangle Pk, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467807522 ER PT J AU Chen, KQ Le, YY Hu, JY Huang, J Gong, WH Bauchiero, S Howard, OMZ Tessarollo, L Wang, JM AF Chen, Keqiang Le, Yingying Hu, Jinyue Huang, Jiang Gong, Wanghua Bauchiero, Samantha Howard, O. M. Zack Tessarollo, Lino Wang, Ji Ming TI An essential role of the G protein-coupled formylpeptide receptor mRPR2 in the development of allergic airway inflammation SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Chen, Keqiang; Huang, Jiang; Howard, O. M. Zack; Wang, Ji Ming] NCI, Mol Immunoregulat Lab, Frederick, MD 21701 USA. [Tessarollo, Lino] NCI, Mouse Canc Genet Program, Frederick, MD 21701 USA. [Le, Yingying] Shanghai Inst Biol Sci, Lab Immunol & Inflammatory Dis, Shanghai, Peoples R China. [Hu, Jinyue] Xiang Ya Sch Med, Canc Res Inst, Changsha, Hunan, Peoples R China. [Gong, Wanghua] SAIC Frederick, Mol Immunoregulat Lab, Frederick, MD USA. [Bauchiero, Samantha] NCI, Expt Immunol Lab, Frederick, MD 21701 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800813 ER PT J AU Chen, LW Caballero, B Loria, C Lin, PH Champagne, C Elmer, P Ard, J Svetkey, L Appel, L AF Chen, Liwei Caballero, Benjamin Loria, Catherine Lin, Pao-Hwa Champagne, Catherine Elmer, Patricia Ard, Jamy Svetkey, Laura Appel, Lawrence TI Effect of sugar-sweetened drink consumption on blood pressure in US adults: results from the PREMIER trial SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Chen, Liwei; Caballero, Benjamin] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD 20892 USA. [Loria, Catherine] NHLBI, Bethesda, MD USA. [Lin, Pao-Hwa; Svetkey, Laura] Duke Univ, Durham, NC USA. [Champagne, Catherine] Pennington Biomed Res Ctr, Baton Rouge, LA USA. [Elmer, Patricia] Kaiser Permanente Ctr Hlth Res, Portland, OR USA. [Ard, Jamy] Univ Alabama Birmingham, Birmingham, AL 21205 USA. [Appel, Lawrence] Johns Hopkins Med Inst, Baltimore, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700180 ER PT J AU Chen, QY Akiba, H Paton, JC Cannons, J Schwartzberg, PL Snapper, C AF Chen, Quanyi Akiba, Hisaya Paton, James C. Cannons, Jennifer Schwartzberg, Pamela L. Snapper, Clifford TI The CD4+T cell- and SAP-dependent IgG anti-polysaccharide response to intact Streptococcus pneumoniae, in contrast to pneumococcal conjugate vaccine, is ICOS-independent SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Chen, Quanyi; Snapper, Clifford] Uniformed Serv Univ Hlth Sci, Dept Pathol, Bethesda, MD 20814 USA. [Akiba, Hisaya] Juntendo Univ, Sch Med, Dept Immunol, Tokyo 113, Japan. [Paton, James C.] Univ Adelaide, Dept Mol Biosci, Adelaide, SA, Australia. [Schwartzberg, Pamela L.] NHGRI, NIH, Bethesda, MD 20892 USA. RI Paton, James/A-9920-2008 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467804408 ER PT J AU Chen, YP Coulter, S Jetten, AM Goldstein, JA AF Chen, Yuping Coulter, Sherry Jetten, Anton M. Goldstein, Joyce A. TI The retinoic acid receptor-related orphan receptors (RORs) regulates human CYP2C8 SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Chen, Yuping; Coulter, Sherry; Goldstein, Joyce A.] NIEHS, LPC, NIH, Res Triangle Pk, NC USA. [Jetten, Anton M.] NIEHS, LRB, NIH, Res Triangle Pk, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700622 ER PT J AU Chen, YP Coulter, S Jetten, AM Goldstein, JA AF Chen, Yuping Coulter, Sherry Jetten, Anton M. Goldstein, Joyce A. TI The retinoic acid receptor-related orphan receptors (RORs) regulate human CYP2C8 SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Chen, Yuping; Coulter, Sherry] NIEHS, LPC, NIH, Res Triangle Pk, NC USA. [Jetten, Anton M.] NIEHS, LRB, NIH, Res Triangle Pk, NC 27709 USA. [Goldstein, Joyce A.] NIEHS, LPC, NIH, Res Triangle Pk, NC 27709 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700614 ER PT J AU Cho, HY Miller-DeGraff, L Talalay, P Yamamoto, M Kleeberger, S AF Cho, Hye-Youn Miller-DeGraff, Laura Talalay, Paul Yamamoto, Masayuki Kleeberger, Steven TI Enhanced resistance to oxidative lung injury by an Nrf2-ARE inducer in mice SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Cho, Hye-Youn; Miller-DeGraff, Laura; Kleeberger, Steven] NIEHS, Lab Resp Biol, Res Triangle Pk, NC 27709 USA. [Talalay, Paul] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Yamamoto, Masayuki] Tohoku Univ, Grad Sch Med, Sendai, Miyagi 980, Japan. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467803249 ER PT J AU Cho, H Park, C Hwang, IY Han, SB Kehrl, JH AF Cho, Hyeseon Park, Chung Hwang, Il-Young Han, Sang-Bae Kehrl, John H. TI Hypotension in RGS5-deficient mice SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Cho, Hyeseon; Park, Chung; Hwang, Il-Young; Kehrl, John H.] NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA. [Han, Sang-Bae] Chungbuk Natl Univ, Coll Pharm, Cheongju, Chungbuk, South Korea. NR 0 TC 0 Z9 0 U1 0 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800585 ER PT J AU Choi, JH Williams, J Cho, J Falck, J Shears, SB AF Choi, Jae H. Williams, Jason Cho, Jaiesoon Falck, J. Shears, Stephen B. TI Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Choi, Jae H.; Cho, Jaiesoon; Shears, Stephen B.] NIEHS, LST, NIH, Res Triangle Pk, NC USA. [Williams, Jason] NIEHS, PMCF, NIH, Res Triangle Pk, NC USA. [Falck, J.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467804102 ER PT J AU Chung, YW Bin Yim, M Chock, PB AF Chung, Youn Wook Bin Yim, Moon Chock, P. Boon TI Protein Kinase C-dependent Manganese Superoxide Dismutase (MnSOD) Regulation in A549 cells SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Chung, Youn Wook] NHLBI, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801766 ER PT J AU Combs, GF Watts, JC Johnson, LK Canfield, WK Davis, CD Milner, JA AF Combs, Gerald F. Watts, Jennifer C. Johnson, LuAnn K. Canfield, Wesley K. Davis, Cindy D. Milner, John A. TI Responses to selenium supplementation in healthy Americans SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Combs, Gerald F.; Watts, Jennifer C.; Johnson, LuAnn K.; Canfield, Wesley K.] ARS, USDA, GF Human Nutr Res Ctr, Grand Forks, ND USA. [Davis, Cindy D.] NCI, NIH, Bethesda, MD 20892 USA. [Milner, John A.] NCI, NIH, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802356 ER PT J AU Combs, GF Watts, JC Johnson, LK Canfield, WK Davis, CD Milner, JA AF Combs, Gerald F. Watts, Jennifer C. Johnson, Luann K. Canfield, Wesley K. Davis, Cindy D. Milner, John A. TI Absence of diabetes indicators in a selenium-supplementation trial SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Combs, Gerald F.; Watts, Jennifer C.; Johnson, Luann K.; Canfield, Wesley K.] ARS, USDA, GF Human Nutr Res Ctr, Grand Forks, ND USA. [Davis, Cindy D.] NCI, NIH, Bethesda, MD 20892 USA. [Milner, John A.] NCI, NIH, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802337 ER PT J AU Coppola, V Tessarollo, L AF Coppola, Vincenzo Tessarollo, Lino TI Tamalin may cooperate with Cybr in modulating leukocyte migration in vivo SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Coppola, Vincenzo; Tessarollo, Lino] NCI Ctr Canc Res, Mouse Canc Genet Program, Frederick, MD USA. RI Coppola, Vincenzo/E-2917-2011 OI Coppola, Vincenzo/0000-0001-6163-1779 NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806424 ER PT J AU Crotty, S Moutaftsi, M McCausland, M Quiroz, JM Garboczi, D Felgner, P Sette, A AF Crotty, Shane Moutaftsi, Magdalini McCausland, Megan Quiroz, Juan Moyron Garboczi, David Felgner, Philip Sette, Alessandro TI Selective CD4 T cell help for B cell and antibody responses to vaccinia SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Crotty, Shane; Moutaftsi, Magdalini; McCausland, Megan; Quiroz, Juan Moyron; Sette, Alessandro] La Jolla Inst Allergy & Immunol LIAI, La Jolla, CA USA. [Garboczi, David] NIH Twinbrook, Rockville, MD USA. [Felgner, Philip] UC Irvine, Irvine, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467808765 ER PT J AU Cruz, AC Ramaswamy, M Siegel, RM AF Cruz, Anthony C. Ramaswamy, Madhu Siegel, Richard M. TI Human CD4+effector memory T cells are pre-sensitized to Fas-induced apoptosis due to more efficient receptor signaling SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Cruz, Anthony C.; Ramaswamy, Madhu; Siegel, Richard M.] NIAMS, NIH, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467807430 ER PT J AU Cui, YZ Mackall, C AF Cui, Yongzhi Mackall, Crystal TI Depletion of CD25+T cells and IL-7 administration enhanced anti-tumor effects in mice with B16 melanoma SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Cui, Yongzhi; Mackall, Crystal] NCI, Pediat Oncol Branch, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467805456 ER PT J AU Dalal, MS Ferrucci, L Sun, K Fried, L Varadhan, R Walston, J Guralnik, J Semba, R AF Dalal, Mansi Sunil Ferrucci, Luigi Sun, Kai Fried, Linda Varadhan, Ravi Walston, Jermey Guralnik, Jack Semba, Richard TI Elevated serum advanced glycation end products and poor grip strength in older community-dwelling women SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Dalal, Mansi Sunil; Sun, Kai; Fried, Linda; Varadhan, Ravi; Walston, Jermey; Semba, Richard] Johns Hopkins Med Inst, Baltimore, MD 21205 USA. [Ferrucci, Luigi] NIA, Longitudinal Studies Sect, Baltimore, MD 21224 USA. [Guralnik, Jack] NIA, Epidemiol Demog & Biometry Branch, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467804055 ER PT J AU Das, A Long, E AF Das, Asmita Long, Eric TI Granule polarization is the preferred target for inhibition by NK cell inhibitory receptors SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Das, Asmita; Long, Eric] NIAID, LIG, NIH, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800151 ER PT J AU Davis, JS Zhang, D Cherry, S Tropea, J Waugh, D Wlodawer, A AF Davis, Jamaine S. Zhang, Di Cherry, Scott Tropea, Joseph Waugh, David Wlodawer, Alexander TI Crystallization and preliminary X-ray analysis of the secreted VirA effector protein from Shigella SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Davis, Jamaine S.; Zhang, Di; Cherry, Scott; Tropea, Joseph; Waugh, David; Wlodawer, Alexander] NCI, Macromol Crystallog Lab, Frederick, MD 21701 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801632 ER PT J AU de la Rosa, G Tewary, P Yang, D Oppenheim, JJ AF de la Rosa, Gonzalo Tewary, Poonam Yang, De Oppenheim, Joost J. TI Human Lactoferrin attracts monocytes and activates monocyte-derived Dendritic Cells to become mature antigen-presenting cells SO FASEB JOURNAL LA English DT Meeting Abstract C1 [de la Rosa, Gonzalo; Tewary, Poonam; Oppenheim, Joost J.] NCI, Mol Immunoregulat Lab, Frederick, MD 21701 USA. [Yang, De] SAIC Frederick, Mol Immunoregulat Lab, Frederick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700004 ER PT J AU DeKeyser, JG Bryant, SD Omiecinski, CJ AF DeKeyser, Joshua G. Bryant, Sharon D. Omiecinski, Curtis J. TI Distinct pharmacological activities associated with naturally occurring splice variants of the human constitutive androstane receptor SO FASEB JOURNAL LA English DT Meeting Abstract C1 [DeKeyser, Joshua G.; Omiecinski, Curtis J.] Penn State Univ, University Pk, PA 16802 USA. [Bryant, Sharon D.] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806305 ER PT J AU Dessalines, M Finnigan, M Hromi-Fiedler, A Pachon, H Perez-Escamilla, R AF Dessalines, Michael Finnigan, Mousson Hromi-Fiedler, Amber Pachon, Helena Perez-Escamilla, Rafael TI Dietary food intake patterns among women in rural South Haiti SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Dessalines, Michael; Hromi-Fiedler, Amber; Perez-Escamilla, Rafael] Univ Connecticut, Storrs, CT USA. [Finnigan, Mousson] ORE, Camp Perrin, Haiti. [Hromi-Fiedler, Amber; Perez-Escamilla, Rafael] Connecticut NIH EXPORT Ctr Excellence Eliminating, Storrs, CT USA. [Pachon, Helena] CIAT, Cali, Colombia. NR 0 TC 0 Z9 0 U1 0 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467809282 ER PT J AU Dmitrieva, NI Chen, H Nussenzweig, A Burg, MB AF Dmitrieva, Natalia I. Chen, Henry Nussenzweig, Andre Burg, Maurice B. TI Disturbed water balance in Ku86(-/-) mice SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Dmitrieva, Natalia I.; Burg, Maurice B.] NHLBI, NIH, Bethesda, MD 20892 USA. [Chen, Henry; Nussenzweig, Andre] NCI, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467804474 ER PT J AU Dmitrieva, NI Burg, MB AF Dmitrieva, Natalia I. Burg, Maurice B. TI Histone H2AX becomes phosphorylated in response to high NaCl in apoptotic cells, but not in viable ones SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Dmitrieva, Natalia I.; Burg, Maurice B.] NHLBI, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802804 ER PT J AU Dwyer, DM Owings, JP Joshi, MB AF Dwyer, Dennis M. Owings, Joshua P. Joshi, Manju B. TI Molecular and Functional Characterization of a Unique Secretory Nuclease [LdNuc(s)] from the Human Protozoan Pathogen, Leishmania donovani SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Dwyer, Dennis M.; Owings, Joshua P.; Joshi, Manju B.] NIAID, Cell Biol Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800740 ER PT J AU Fedorova, I Hussein, N Salem, N AF Fedorova, Irina Hussein, Nahed Salem, Norman, Jr. TI Deficit of Prepulse Inhibition in Mice Caused by Dietary n-3 Fatty Acid Deficiencies SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Fedorova, Irina; Hussein, Nahed; Salem, Norman, Jr.] NIAAA, NIH, Rockville, MD 20852 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801473 ER PT J AU Fenton, RA Moller, HB Nielsen, S Hoffert, JD Knepper, MA AF Fenton, Robert A. Moller, Hanne B. Nielsen, Soren Hoffert, Jason D. Knepper, Mark A. TI Localization and Regulation of Phosphorylated forms of Aquaporin-2 in vivo SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Fenton, Robert A.; Moller, Hanne B.; Nielsen, Soren] Univ Aarhus, Water & Salt Res Ctr, Aarhus, Denmark. [Hoffert, Jason D.; Knepper, Mark A.] NHLBI, LKEM, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467805619 ER PT J AU Franco, R Cidlowski, JA AF Franco, Rodrigo Cidlowski, John A. TI Glutathione Transport Regulates FasL-induced Apoptosis in Lymphoma Cells by Modulating Apoptotic Volume Decrease and Changes in Ionic Homeostasis SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Franco, Rodrigo; Cidlowski, John A.] NIEHS, Lab Signal Transduct, NIH, Res Triangle Pk, NC 27709 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700005 ER PT J AU Gaffen, S Kramer, JM Hanel, W Shen, F Malone, JP Maitra, A Isik, N Swart, D Tocker, J Jin, T AF Gaffen, Sarah Kramer, Jill M. Hanel, Walter Shen, Fang Malone, James P. Maitra, Amarnath Isik, Nilgun Swart, David Tocker, Joel Jin, Tian TI Subunit Dynamics in the IL-17 Receptor Complex: Identification of a Pre-ligand Assembly Domain (PLAD) and Ligand Binding site in IL-17RA SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Gaffen, Sarah; Kramer, Jill M.; Hanel, Walter; Shen, Fang; Malone, James P.; Maitra, Amarnath] SUNY Buffalo, Buffalo, NY 14260 USA. [Isik, Nilgun; Jin, Tian] NIAID, Rockville, MD USA. [Swart, David; Tocker, Joel] Amgen Inc, Seattle, WA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800221 ER PT J AU Gallazzini, M Kunin, M Burg, MB Ferraris, JD AF Gallazzini, Morgan Kunin, Margarita Burg, Maurice B. Ferraris, Joan D. TI Role of cyclin dependent kinase 5 (CDK5) and c-Abl in high NaCl-induced nuclear localization of the osmoprotective transcription factor, TonEBP/OREBP SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Gallazzini, Morgan; Kunin, Margarita; Burg, Maurice B.; Ferraris, Joan D.] NHLBI, LKEM, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802864 ER PT J AU Galloway-Yunusah, M Stadtman, TC AF Galloway-Yunusah, Michelle Stadtman, Thressa C. TI Specific Binding of GAPDH in the Presence or Absence of Selenium to SPS Monitored by Affinity Chromatography SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Galloway-Yunusah, Michelle; Stadtman, Thressa C.] NHLBI, Biochem Lab, BBC, DIR,NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467809447 ER PT J AU Gautam, D Jeon, J Starost, MF Han, SJ Hamdan, F Gavrilova, O Parlow, AF Cui, YH Wess, J AF Gautam, Dinesh Jeon, Jongrye Starost, Matthew F. Han, Sung-Jun Hamdan, Fadi Gavrilova, Oksana Parlow, Albert F. Cui, Yinghong Wess, Jurgen TI Brain-specific deletion of M3 muscarinic acetylcholine receptor causes dwarfism in mice SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Gautam, Dinesh; Jeon, Jongrye; Han, Sung-Jun; Hamdan, Fadi; Cui, Yinghong; Wess, Jurgen] NIDDK, LBC, NIH, Bethesda, MD USA. [Starost, Matthew F.] NIH, OD, Bethesda, MD 20892 USA. [Gavrilova, Oksana] NIDDK, Mouse Metab Core Lab, NIH, Bethesda, MD USA. [Parlow, Albert F.] Harbor UCLA Med Ctr, Torrance, CA 90509 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801606 ER PT J AU Gerdin, MJ Eiden, LE AF Gerdin, Matthew J. Eiden, Lee E. TI PACAP regulates transcription of the Ier3 gene during PC12 cell differentiation via calcium-dependent activation of a non-canonical (PKA-independent) cAMP signaling pathway that activates ERK and Elk SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Gerdin, Matthew J.; Eiden, Lee E.] NIMH, Lab Cellular & Mol Regulat, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806846 ER PT J AU Ghosh, MC Collins, GD Carter, A Vandanmagsar, B Brill, M Lustig, A Becker, KG Wood, WW Emeche, CD French, AD O'Connell, MP Dissanayake, SK Weeraratne, AT Taub, DD AF Ghosh, Manik C. Collins, Gary D. Carter, Arnell Vandanmagsar, Bolormaa Brill, Margaret Lustig, Ana Becker, Kevin G. Wood, William W., III Emeche, Chineya D. French, Amanda D. O'Connell, Michael P. Dissanayake, Samudra K. Weeraratne, Ashani T. Taub, Dennis D. TI CXCL12 mediates T-cell migration via activation of the non-canonical Wnt signaling pathway SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Ghosh, Manik C.; Collins, Gary D.; Carter, Arnell; Vandanmagsar, Bolormaa; Brill, Margaret; Lustig, Ana; Becker, Kevin G.; Wood, William W., III; Emeche, Chineya D.; French, Amanda D.; O'Connell, Michael P.; Dissanayake, Samudra K.; Weeraratne, Ashani T.; Taub, Dennis D.] NIA, Immunol Lab, Baltimore, MD 21224 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467804384 ER PT J AU Gibbs, BC Schimel, D Yu, Q Chatterjee, B Lo, C AF Gibbs, Brian Clemon Schimel, Dan Yu, Qing Chatterjee, Bishwanath Lo, Cecilia TI Skeletal malformations associated with mutations causing left-right patterning defects SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Gibbs, Brian Clemon; Yu, Qing; Chatterjee, Bishwanath; Lo, Cecilia] NHLBI, Dev Biol Lab, NIH, Bethesda, MD 20892 USA. [Schimel, Dan] NIH, Mouse Imaging Facil, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467807181 ER PT J AU Goldstein, DS Holmes, C Sharabi, Y AF Goldstein, David S. Holmes, Courtney Sharabi, Yehonatan TI Pharmacologic Probes to Differentiate Chronic Autonomic Failure Syndromes SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Goldstein, David S.; Holmes, Courtney; Sharabi, Yehonatan] NINDS, Clin Neurocardiol Sect, CNP, DIR,NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806792 ER PT J AU Gonzales, PA Pisitkun, T Hoffert, J Star, RA Wang, NS Knepper, MA AF Gonzales, Patricia A. Pisitkun, Trairak Hoffert, Jason Star, Robert A. Wang, Nam Sun Knepper, Mark A. TI Phosphoproteomics of Human Urinary Exosomes SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Gonzales, Patricia A.; Wang, Nam Sun] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. [Gonzales, Patricia A.; Pisitkun, Trairak; Hoffert, Jason; Knepper, Mark A.] NHLBI, LKEM, Bethesda, MD 20892 USA. [Star, Robert A.] NIDDK, Renal Diagnost & Therapeut Unit, Bethesda, MD USA. RI Wang, Nam Sun/E-4253-2016 NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467808719 ER PT J AU Graves, JP Zhang, DH Maestro, MA Servitja, JM King, LM Swope, DL Korach, KS Ferrer, J Zeldin, DC AF Graves, Joan P. Zhang, Donghui Maestro, Miguel A. Servitja, Joan M. King, Lorraine M. Swope, Deborah L. Korach, Kenneth S. Ferrer, Jorge Zeldin, Darryl C. TI Molecular mechanisms involved in the regulation of the cytochrome P450 epoxygenase CYP2J5 SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Graves, Joan P.; Zhang, Donghui; King, Lorraine M.; Swope, Deborah L.; Korach, Kenneth S.; Zeldin, Darryl C.] NIEHS, NIH, Res Triangle Pk, NC 27709 USA. [Maestro, Miguel A.; Servitja, Joan M.; Ferrer, Jorge] Inst Invest August Pi i Sunyer, Barcelona, Spain. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800371 ER PT J AU Grimley, PM Henson, DE Schwartz, AM Anderson, WF AF Grimley, Philip M. Henson, Donald E. Schwartz, Arnold M. Anderson, William F. TI Pathobiology of ovarian epithelial cancers (OEC) in relation to age-specific incidence rates (ASIR) SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Grimley, Philip M.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Henson, Donald E.] George Washington Univ, Off Canc Prevent & Control, Inst Canc, Washington, DC USA. [Anderson, William F.] NCI, Div Canc Epidemiol & Genet, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806696 ER PT J AU Guenther, PM Juan, WY Reedy, J Britten, P Lino, M Carlson, A Hiza, HH Krebs-Smith, SM AF Guenther, Patricia M. Juan, WenYen Reedy, Jill Britten, Patricia Lino, Mark Carlson, Andrea Hiza, Hazel H. Krebs-Smith, Susan M. TI Diet quality of Americans in 1994-1996 and 2001-2002 as measured by the Healthy Eating Index-2005 SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Guenther, Patricia M.; Juan, WenYen; Britten, Patricia; Lino, Mark; Carlson, Andrea; Hiza, Hazel H.] USDA, Ctr Nutr Policy & Promot, Alexandria, VA USA. [Reedy, Jill; Krebs-Smith, Susan M.] NCI, Appl Res Program, Div Canc Prevent & Control, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 3 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467803706 ER PT J AU Gustchina, A AF Gustchina, Alla TI Eukaryotic and retroviral aspartic proteases: similarities and differences SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Gustchina, Alla] NCI, Frederick, MD 21701 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800191 ER PT J AU Gutti, RK Tsai-Morris, CH Dufau, ML AF Gutti, Ravi Kumar Tsai-Morris, Chon-Hwa Dufau, Maria L. TI Gonadotropin-Regulated Testicular Helicase (GRTH/Ddx25): A Negative Regulator of Apoptosis in Male Germ Cells SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Gutti, Ravi Kumar; Tsai-Morris, Chon-Hwa; Dufau, Maria L.] NICHD, ERRB, PDEGEN, NIH, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801736 ER PT J AU Gyulai, Z Salcedo, R Dai, RM Anderson, K Lyakh, L Mazzoni, A Young, M Colburn, N Oshima, A Grivennikov, S Nedospasov, S AF Gyulai, Zsofia Salcedo, Rosalba Dai, Ren-Ming Anderson, Kimberley Lyakh, Lyudmila Mazzoni, Alessandra Young, Matthew Colburn, Nancy Oshima, Akira Grivennikov, Sergei Nedospasov, Sergei TI Role of TNF in colon carcinogenesis SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Gyulai, Zsofia; Anderson, Kimberley; Lyakh, Lyudmila; Mazzoni, Alessandra] NCI, LEI, CIP, CCR, Frederick, MD 21701 USA. [Young, Matthew; Colburn, Nancy; Grivennikov, Sergei] NCI, LCP, CCR, Frederick, MD 21701 USA. [Salcedo, Rosalba; Dai, Ren-Ming] SAIC Frederick, LEI, CIP, Frederick, MD USA. [Oshima, Akira] NCI, LCBG, Bethesda, MD 20892 USA. [Nedospasov, Sergei] VA Engelhardt Mol Biol Inst, Moscow 117984, Russia. RI Nedospasov, Sergei/J-5936-2013; Nedospasov, Sergei/L-1990-2015; Nedospasov, Sergei/Q-7319-2016 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467803205 ER PT J AU Hall, JA Sun, CM Bouladoux, N Belkaid, Y AF Hall, Jason Alan Sun, Cheng-Ming Bouladoux, Nicolas Belkaid, Yasmine TI Generation and modulation of Foxp3+Treg conversion by gut-resident tissue factors SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Hall, Jason Alan; Sun, Cheng-Ming; Bouladoux, Nicolas; Belkaid, Yasmine] NIH, Lab Parasist Dis, Bethesda, MD 20892 USA. [Hall, Jason Alan] Univ Penn, Immunol Grad Grp, Philadelphia, PA 19104 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467808314 ER PT J AU Hall, KD Jordan, PN AF Hall, Kevin D. Jordan, Peter N. TI Dynamic coordination of macronutrient balance during infant growth: Insights from a mathematical model SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Hall, Kevin D.; Jordan, Peter N.] NIDDK, NIH, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467807895 ER PT J AU Hall, KD Hallgreen, CE AF Hall, Kevin D. Hallgreen, Christine E. TI Changes of Visceral Fat Mass are Allometrically Related to Total Body Fat Independent of Gender or Weight Loss Intervention SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Hall, Kevin D.] NIDDK, NIH, Bethesda, MD USA. [Hallgreen, Christine E.] Tech Univ Denmark, Copenhagen, Denmark. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806613 ER PT J AU Hattab, EM Cheng, L Al-Khatib, SM Steeg, PS AF Hattab, Eyas M. Cheng, Liang Al-Khatib, Sohaib M. Steeg, Patricia S. TI Metastasizing breast carcinoma to the brain: a clinicopathologic and immunohistochemical study of 14 matched pairs. SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Hattab, Eyas M.; Cheng, Liang; Al-Khatib, Sohaib M.] Indiana Univ, Indianapolis, IN 46204 USA. [Steeg, Patricia S.] NCI, Mol Pharmacol Lab, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467805301 ER PT J AU Haymaker, CL Divekar, R Cascio, J Yu, P Zaghouani, H AF Haymaker, Cara L. Divekar, Rohit Cascio, Jason Yu, Ping Zaghouani, Habib TI High affinity interactions promote T regulatory positive selection in the thymus SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Haymaker, Cara L.; Divekar, Rohit; Cascio, Jason; Zaghouani, Habib] Univ Missouri, Columbia, MO USA. [Yu, Ping] NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467803145 ER PT J AU Hazelwood, LA Free, RB Cabrera, DM Sibley, DR AF Hazelwood, Lisa A. Free, R. Benjamin Cabrera, David M. Sibley, David R. TI Dopamine receptor interacting proteins: unraveling the receptor signalplex SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Hazelwood, Lisa A.; Free, R. Benjamin; Cabrera, David M.; Sibley, David R.] NINDS, Mol Neuropharmacol Sect, NIH, Rockville, MD USA. RI Cabrera, David/I-1013-2014 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801712 ER PT J AU Hegde, R AF Hegde, Ramanujan TI The biosynthesis of secretory and membrane proteins SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Hegde, Ramanujan] NICHHD, Cell Biol & Metab Branch, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800630 ER PT J AU Hesse, M Wilson, MS Mahamed, D Cheever, AW Wynn, TA Bajracharya, S AF Hesse, Matthias Wilson, Mark S. Mahamed, Deeqa Cheever, Allen W. Wynn, Thomas A. Bajracharya, Siddhartha TI Expression of CD103 by Foxp3+regulatory T cells is critical for protective immune regulation in schistosomiasis SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Hesse, Matthias; Mahamed, Deeqa; Bajracharya, Siddhartha] Cornell Univ, Vet Coll, Ithaca, NY USA. [Wilson, Mark S.; Wynn, Thomas A.] NIAID, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA. [Cheever, Allen W.] Biomed Res Inst, Rockville, MD 20852 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467808729 ER PT J AU Hiranita, T Newman, AH Katz, JL AF Hiranita, Takato Newman, Amy H. Katz, Jonathan L. TI Assessment of Reinforcing Effects of Benztropine Analogues and Their Effects on Cocaine Self-Administration: Comparisons with Monoamine Uptake Inhibitors SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Hiranita, Takato; Katz, Jonathan L.] NIDA Intramural Res Program, MDRB Psychobiol Sect, Baltimore, MD USA. [Newman, Amy H.] NIDA Intramural Res Program, MDRB Med Chem Sect, Baltimore, MD USA. RI Hiranita, Takato/G-6567-2011 NR 0 TC 0 Z9 0 U1 0 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467809341 ER PT J AU Hoffert, J Pisitkun, T McDill, B Chen, F Fenton, R Knepper, M AF Hoffert, Jason Pisitkun, Trairak McDill, Brad Chen, Feng Fenton, Rob Knepper, Mark TI Vasopressin regulates phosphorylation of aquaporin-2 (AQP2) at ser-264 and ser-269 SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Hoffert, Jason; Pisitkun, Trairak; Knepper, Mark] NIH, Bethesda, MD 20892 USA. [McDill, Brad; Chen, Feng] Washington Univ, St Louis, MO USA. [Fenton, Rob] Univ Aarhus, Aarhus, Denmark. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467803390 ER PT J AU Hong, SH Ren, L Khanna, C AF Hong, Sung-Hyeok Ren, Ling Khanna, Chand TI Ezrin enhances survival of single metastatic osteosarcoma cells that reach the lung in an AKT-independent manner SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Hong, Sung-Hyeok; Ren, Ling; Khanna, Chand] NCI, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800461 ER PT J AU Hromi-Fiedler, A Bermudez-Millan, A Chapman, D Perez-Escamilla, S Damio, G Melgar-Quinonez, H Perez-Escamilla, R AF Hromi-Fiedler, Amber Bermudez-Millan, Angela Chapman, Donna Perez-Escamilla, Sofia Damio, Grace Melgar-Quinonez, Hugo Perez-Escamilla, Rafael TI A U shaped relationship exists between food insecurity and excessive gestational weight gain among low-income Latinas SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Hromi-Fiedler, Amber; Bermudez-Millan, Angela; Chapman, Donna; Perez-Escamilla, Rafael] Univ Connecticut, Dept Nutr Sci, Storrs, CT USA. [Hromi-Fiedler, Amber; Bermudez-Millan, Angela; Chapman, Donna; Perez-Escamilla, Rafael] Connecticut NIH EXPORT Ctr Excellence Eliminating, Storrs, CT USA. [Perez-Escamilla, Sofia; Damio, Grace] Hispan Hlth Council, Hartford, CT USA. [Melgar-Quinonez, Hugo] Ohio State Univ, Dept Human Nutr, Columbus, OH 43210 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801474 ER PT J AU Hromi-Fiedler, A Bermudez-Millan, A Chapman, D Segura-Perez, S Damio, G Melgar-Quinonez, H Perez-Escamilla, R AF Hromi-Fiedler, Amber Bermudez-Millan, Angela Chapman, Donna Segura-Perez, Sofia Damio, Grace Melgar-Quinonez, Hugo Perez-Escamilla, Rafael TI Household food security status before pregnancy as a risk factor for delivering a low birthweight infant SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Hromi-Fiedler, Amber; Bermudez-Millan, Angela; Chapman, Donna; Perez-Escamilla, Rafael] Univ Connecticut, Dept Nutr Sci, Storrs, CT USA. [Hromi-Fiedler, Amber; Bermudez-Millan, Angela; Chapman, Donna; Perez-Escamilla, Rafael] Connecticut NIH EXPORT Ctr Excellence Eliminating, Storrs, CT USA. [Segura-Perez, Sofia; Damio, Grace] Hispan Hlth Council, Hartford, CT USA. [Melgar-Quinonez, Hugo] Ohio State Univ, Dept Human Nutr, Columbus, OH 43210 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800744 ER PT J AU Hu, JX Li, JH Costanzi, S Zhang, XH Wess, J AF Hu, Jianxin Li, Jianhua Costanzi, Stefano Zhang, Xiaohong Wess, Jurgen TI Mapping of Contact Sites Between the M3 Muscarinic Acetylcholine Receptor and Gq by Cross-linking Approaches SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Hu, Jianxin; Li, Jianhua; Zhang, Xiaohong; Wess, Jurgen] NIDDK, Bioorgan Chem Lab, Bethesda, MD 20892 USA. [Costanzi, Stefano] NIDDK, Lab Biol Modeling, NIH, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700205 ER PT J AU Huang, J Zhou, Y Bian, X Le, YY Gong, W Chen, K Wang, JM AF Huang, Jian Zhou, Y. Bian, X. Le, Y. Y. Gong, W. Chen, K. Wang, J. M. TI The formylpeptide receptor FPR exploits the function of the epidermal growth factor receptor to promote the progression of glioblastoma SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Zhou, Y.] Fudan Univ, Canc Hosp, Shanghai 200433, Peoples R China. [Huang, Jian; Chen, K.; Wang, J. M.] NCI, LMI, Frederick, MD 21701 USA. [Bian, X.] South West Hosp, Inst Pathol, Chongqing, Peoples R China. [Le, Y. Y.] Inst Nutr Sci, Lab Immunol & Inflammatory Dis, Shanghai, Peoples R China. [Gong, W.] NCI, SAIC Frederick, BRP, Frederick, MD 21701 USA. RI Bian, Xiu-wu/D-4736-2017 OI Bian, Xiu-wu/0000-0003-4383-0197 NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801435 ER PT J AU Huang, MC Liao, JJ Bonasera, S Longo, DL Goetzl, EJ AF Huang, Mei-Chuan Liao, Jia-Jun Bonasera, Stephen Longo, Dan L. Goetzl, Edward J. TI Aging-Induced NF-kappa B-Dependent Alterations in T Cell Cytokines SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Huang, Mei-Chuan; Liao, Jia-Jun; Bonasera, Stephen; Goetzl, Edward J.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Longo, Dan L.] NIA, Lab Immunol, NIH, Baltimore, MD 21224 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802332 ER PT J AU Iacono, D O'Brien, R Resnick, SM Zonderman, A Pletnikova, O Rudow, G Yang, A West, MJ Crain, B Troncoso, JC AF Iacono, Diego O'Brien, Richard Resnick, Susan M. Zonderman, Alan Pletnikova, Olga Rudow, Gay Yang, An West, Mark J. Crain, Barbara Troncoso, Juan C. TI Neuronal hypertrophy in asymptomatic Alzheimer's Disease in the BLSA SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Iacono, Diego; Pletnikova, Olga; Rudow, Gay; Crain, Barbara; Troncoso, Juan C.] Johns Hopkins Univ, Div Neuropathol, Baltimore, MD USA. [Resnick, Susan M.; Zonderman, Alan; Yang, An] NIA, Lab Personal & Cognit, Baltimore, MD 21224 USA. [West, Mark J.] Inst Anat, DK-8000 Aarhus, Denmark. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802080 ER PT J AU Isik, N Brzostowski, J Jin, T AF Isik, Nilgun Brzostowski, Joseph Jin, Tian TI An Elmo-like protein that negatively regulates F-actin dynamics SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Isik, Nilgun; Brzostowski, Joseph; Jin, Tian] NIAID, NIH, LIG, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700158 ER PT J AU Jacobson, KA Fricks, I Melman, A Carter, R Ivanov, AA Harden, TK Ko, H AF Jacobson, Kenneth A. Fricks, Ingrid Melman, Artem Carter, Rhonda Ivanov, Andrei A. Harden, T. Kendall Ko, Hyojin TI The glucose moiety of uridine 5 '-diphosphoglucose is structurally permissive in activation of the human P2Y14 receptor SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Jacobson, Kenneth A.; Melman, Artem; Ivanov, Andrei A.; Ko, Hyojin] NIDDK, Bioorgan Chem Lab, NIH, Bethesda, MD 20892 USA. [Fricks, Ingrid; Carter, Rhonda; Harden, T. Kendall] Univ N Carolina, Sch Med, Chapel Hill, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802012 ER PT J AU Jeon, J Wortwein, G Fink-Jensen, A Woldbye, DPD Schulein, C Schutz, G Davis, AA Rees, HD Levey, AI Li, CL Deng, CX Cui, YH Wess, J AF Jeon, Jongrye Woertwein, Gitta Fink-Jensen, Anders Woldbye, David P. D. Schulein, Christina Schuetz, Guenther Davis, Albert A. Rees, Howard D. Levey, Allan I. Li, Cuiling Deng, Chuxia Cui, Yinghong Wess, Juergen TI Molecular and behavioral phenotypes caused by selective disruption of M4 muscarinic acetylcholine receptors in D1 dopamine receptor-expressing cells SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Jeon, Jongrye; Cui, Yinghong; Wess, Juergen] NIDDK, LBC, NIH, Bethesda, MD 20892 USA. [Li, Cuiling; Deng, Chuxia] NIDDK, GDDB, NIH, Bethesda, MD 20892 USA. [Woertwein, Gitta; Fink-Jensen, Anders; Woldbye, David P. D.; Schulein, Christina] Univ Copenhagen, Lab Neuropsychiat, Copenhagen, Denmark. [Schuetz, Guenther] German Canc Res Ctr, D-6900 Heidelberg, Germany. [Davis, Albert A.; Rees, Howard D.; Levey, Allan I.] Emory Univ, Sch Med, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801588 ER PT J AU Jia, Y Suzuki, N Yamamoto, M Gassmann, M Noguchi, CT AF Jia, Yi Suzuki, Norio Yamamoto, Masayuki Gassmann, Max Noguchi, Constance Tom TI Erythropoietin in myoblast maintenance and muscle regeneration SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Jia, Yi; Noguchi, Constance Tom] NIH, Mol Med Branch, Bethesda, MD 20892 USA. [Suzuki, Norio] Univ Tsukuba, Ctr TARA, Sendai, Miyagi, Japan. [Suzuki, Norio] Univ Tsukuba, ERATO, JST, Sendai, Miyagi, Japan. [Yamamoto, Masayuki] Univ Tsukuba, Dept Med Biochem, Sendai, Miyagi, Japan. [Gassmann, Max] Univ Zurich, Inst Vet Physiol, Zurich, Switzerland. RI Suzuki, Norio/F-3456-2010 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700244 ER PT J AU Jirmanova, L Sarma, DN Jankovic, D Mittelstadt, P Ashwell, JD AF Jirmanova, Ludmila Sarma, Dandapantula N. Jankovic, Dragana Mittelstadt, Paul Ashwell, Jonathan D. TI Disruption of the p38aTyr323 alternative pathway prevents T cell receptor-mediated p38aTyr323 activation in primary T cells SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Jirmanova, Ludmila; Sarma, Dandapantula N.; Mittelstadt, Paul; Ashwell, Jonathan D.] NIH, Lab Immune Cell Biol, Bethesda, MD 20892 USA. [Jankovic, Dragana] NIH, Parasit Dis Lab, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700349 ER PT J AU Johnson, LA Kaiser, A Paulos, CM Powell, DJ Heemskerk, B Restifo, NP Rosenberg, SA AF Johnson, Laura Alexandra Kaiser, Andrew Paulos, Chrystal M. Powell, Daniel J., Jr. Heemskerk, Bianca Restifo, Nicholas P. Rosenberg, Steven A. TI IL12 polarization of mouse and human T-cells: implications for adoptive immunotherapy SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Johnson, Laura Alexandra; Kaiser, Andrew; Paulos, Chrystal M.; Powell, Daniel J., Jr.; Heemskerk, Bianca; Restifo, Nicholas P.; Rosenberg, Steven A.] NCI, Surg Branch, Bethesdsa, MD USA. [Paulos, Chrystal M.] Abramson Family Canc Res Inst, Philadelphia, PA USA. RI Restifo, Nicholas/A-5713-2008; Johnson, Laura/H-4861-2013 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467807076 ER PT J AU Jozwiak, K Wainer, IW AF Jozwiak, Krzysztof Wainer, Irving W. TI Fenoterol derivatives show multitarget interactions with beta2 adrenergic and 5-HT receptors SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Jozwiak, Krzysztof] Med Univ Lublin, Lublin, Poland. [Wainer, Irving W.] NIA, Baltimore, MD 21224 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806343 ER PT J AU Jozwiak, K Moaddel, R Wainer, IW Arias, H AF Jozwiak, Krzysztof Moaddel, Ruin Wainer, Irving W. Arias, Hugo TI Interaction of ibogaine analogs with the nicotinic acetylcholine receptor SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Jozwiak, Krzysztof] Med Univ Lublin, Lublin, Poland. [Moaddel, Ruin; Wainer, Irving W.] NIA, Clin Invest Lab, Baltimore, MD 21224 USA. [Arias, Hugo] Midwestern Univ, Dept Pharmaceut Sci, Glendale, AZ USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700744 ER PT J AU Kassai, EM Yu, MJ Knepper, MA Chou, CL AF Kassai, Eliza M. Yu, Ming-Jiun Knepper, Mark A. Chou, Chung-Lin TI NKCC1 Is Phosphorylated in Rat Inner Medullary Collecting Duct (IMCD) SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Kassai, Eliza M.; Yu, Ming-Jiun; Knepper, Mark A.; Chou, Chung-Lin] NHLBI, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467809127 ER PT J AU Kawakami, Y Hasegawa, S Yumoto, K Yao, LB Tomimori, Y Tagaya, Y Crotty, S Kawakami, T AF Kawakami, Yuko Hasegawa, Shunji Yumoto, Kenji Yao, Libo Tomimori, Yoshiaki Tagaya, Yutaka Crotty, Shane Kawakami, Toshiaki TI Protection from vaccinia virus-induced severe skin lesions by natural killer cells in a mouse model of eczema vaccinatum SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Kawakami, Yuko; Hasegawa, Shunji; Yumoto, Kenji; Yao, Libo; Tomimori, Yoshiaki; Crotty, Shane; Kawakami, Toshiaki] La Jolla Inst Allergy & Immunol, La Jolla, CA USA. [Tagaya, Yutaka] NCI, Metab Branch, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467808156 ER PT J AU Keay, S Kaczmarek, P Zhang, CO Michejda, C AF Keay, Susan Kaczmarek, Piotr Zhang, Chen-Ou Michejda, Christopher TI Normalization of proliferation and paracellular permeability of bladder epithelial cells from interstitial cystitis patients by a synthetic inhibitor of antiproliferative factor SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Keay, Susan; Zhang, Chen-Ou] Univ Maryland, Sch Med, Baltimore, MD 21201 USA. [Keay, Susan] Univ Maryland, Baltimore VA Med Ctr, Baltimore, MD 21201 USA. [Kaczmarek, Piotr; Michejda, Christopher] NCI, Frederick, MD 21701 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467807614 ER PT J AU Kelly, JA Fava, R Spolski, R Leonard, W Morse, H Bessette, K AF Kelly, John A. Fava, Roy Spolski, Rosanne Leonard, Warren Morse, Herbert Bessette, Katherine TI A STAT5b Transgene is Capable of Inducing CD8+Lymphoblastic Lymphoma in the Absence of Normal TCR/MHC signaling or pre-TCR signaling. SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Kelly, John A.; Fava, Roy; Bessette, Katherine] WRJ VA Dartmouth Med Sch, White River Jct, VT USA. [Spolski, Rosanne; Leonard, Warren] NHLBI, LMI, Bethesda, MD 20892 USA. [Morse, Herbert] NIAID, LIP, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467807506 ER PT J AU Khan, FA Lindh, R Tang, Y Ruishalme, L Ost, A Stalfors, P Degerman, E Manganiello, V AF Khan, Faiyaz Ahmad Lindh, Rebecka Tang, Yan Ruishalme, Lida Ost, Anita Stalfors, Peter Degerman, Eva Manganiello, Vincent TI Differential regulation of adipocyte PDE3B in distinct membrane compartments in response to insulin and CL316243 SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Khan, Faiyaz Ahmad; Tang, Yan; Manganiello, Vincent] NHLBI, TMB, NIH, Bethesda, MD 20892 USA. [Lindh, Rebecka; Degerman, Eva] Lund Univ, Lund, Sweden. [Ruishalme, Lida; Ost, Anita; Stalfors, Peter] Lindkoping Univ, Div Cell Biol, Lindkoping, Sweden. [Ruishalme, Lida; Ost, Anita; Stalfors, Peter] Lindkoping Univ, Diabet Res Ctr, Lindkoping, Sweden. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467808020 ER PT J AU Kibe, R Zvonic, S Iwakuma, T Durum, SK Cui, Y AF Kibe, Ryoko Zvonic, Sanjin Iwakuma, Tomoo Durum, Scott K. Cui, Yan TI P53-dependent and -independent components of IL-2 mediated radioprotection in IL-2 dependent T cell lines SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Kibe, Ryoko; Zvonic, Sanjin; Iwakuma, Tomoo; Cui, Yan] Louisiana State Univ, Hlth Sci Ctr, New Orleans, LA USA. [Durum, Scott K.] NCI, Sect Cytokines & Immun, Frederick, MD 21701 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467809249 ER PT J AU Kim, Y Kai, K Sills, RC AF Kim, Yongbaek Kai, Kiyonori Sills, Robert C. TI The inhibition of insulin-like growth factor 1 receptor pathway targets putative cancer stem cells in human malignant mesothelioma SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Kim, Yongbaek; Kai, Kiyonori] N Carolina State Univ, Raleigh, NC 27695 USA. [Sills, Robert C.] NIEHS, Lab Expt Pathol, Res Triangle Pk, NC USA. NR 0 TC 0 Z9 0 U1 1 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467803725 ER PT J AU Koffarnus, MN Katz, JL AF Koffarnus, Mikhail N. Katz, Jonathan L. TI Drug effects on degraded on non-degraded performance on the 5-choice serial-reaction-time task (5-CSRTT) in rats SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Koffarnus, Mikhail N.; Katz, Jonathan L.] NIDA, DHHS, NIH, Baltimore, MD USA. [Koffarnus, Mikhail N.] Univ Michigan, Ann Arbor, MI 48109 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467803294 ER PT J AU Kole, H Bolland, S AF Kole, Hemanta Bolland, Silvia TI Anti-RNA Antibodies with Differential Specificity towards Polyribonucleotides from a Murine Model of Lupus SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Kole, Hemanta; Bolland, Silvia] NIAID, AFGS, LIG, NIH, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467804388 ER PT J AU Kolli, N Mikolajczyk, J Mukhopadhyay, D Dasso, M Salvesen, G Wilkinson, KD AF Kolli, Nagamalleswari Mikolajczyk, Jowita Mukhopadhyay, Debaditya Dasso, Mary Salvesen, Guy Wilkinson, Keith D. TI Para log specificity of mammalian SENPs for SUMO-1 and SUMO-2 SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Kolli, Nagamalleswari; Wilkinson, Keith D.] Emory Univ, Atlanta, GA 30322 USA. [Mikolajczyk, Jowita; Salvesen, Guy] Burnham Inst, La Jolla, CA 92037 USA. [Mukhopadhyay, Debaditya; Dasso, Mary] NICHD, Lab Gene Regulat & Dev, NIH, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467804726 ER PT J AU Kotsyfakis, M Karim, S Anderson, J Andersen, J Valenzuela, J Mather, T Ribeiro, J AF Kotsyfakis, Michail Karim, Shahid Anderson, Jennifer Andersen, John Valenzuela, Jesus Mather, Thomas Ribeiro, Jose TI Selective human cysteine protease inhibition mediates Ixodes scapularis blood feeding success SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Kotsyfakis, Michail; Anderson, Jennifer; Andersen, John; Valenzuela, Jesus; Ribeiro, Jose] NIAID, Lab Malaria & Vector Res, NIH, Rockville, MD USA. [Karim, Shahid; Mather, Thomas] Univ Rhode Isl, Ctr Vector Borne Dis, Kingston, RI 02881 USA. RI Kotsyfakis, Michail/G-9525-2014 OI Kotsyfakis, Michail/0000-0002-7526-1876 NR 0 TC 0 Z9 0 U1 1 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801660 ER PT J AU Krebs, NF Mazariegos, M Westcott, JE Wright, L Das, A Goco, N Hartwell, T Solomons, NW Raboy, V Angel, L Hambidge, KM AF Krebs, Nancy F. Mazariegos, Manolo Westcott, Jamie E. Wright, Linda Das, Abhik Goco, Norman Hartwell, Tyler Solomons, Noel W. Raboy, Victor Angel, Luis Hambidge, K. Michael TI Effects of zinc (Zn) supplementation and phytate-reduced maize in 6-12 mo infants in Guatemala SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Krebs, Nancy F.; Westcott, Jamie E.; Hambidge, K. Michael] Univ Colorado, Hlth Sci Ctr, Sect Nutr, Denver, CO USA. [Mazariegos, Manolo; Solomons, Noel W.] CeSSIAM, Guatemala City, Guatemala. [Mazariegos, Manolo; Angel, Luis] FANCAP, Guatemala City, Guatemala. [Wright, Linda] NICHD, NIH, Rockville, MD USA. [Das, Abhik] RTI Int, Rockville, MD USA. [Goco, Norman; Hartwell, Tyler] RTI Int, Res Triangle Pk, NC USA. [Raboy, Victor] USDA ARS, Aberdeen, ID USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806701 ER PT J AU Kunin, M Simons, BL Irarrazabal, C Shen, RF Wang, GH Burg, MB Ferraris, JD AF Kunin, Margarita Simons, Brigitte L. Irarrazabal, Carlos Shen, Rong-Fong Wang, Guanghui Burg, Maurice B. Ferraris, Joan D. TI LC-MS/MS identification of amino acids that are phosphorylated in the osmoprotective transcription factor, TonEBP/OREBP SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Kunin, Margarita; Simons, Brigitte L.; Irarrazabal, Carlos; Shen, Rong-Fong; Wang, Guanghui; Burg, Maurice B.; Ferraris, Joan D.] NHLBI, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467803422 ER PT J AU Labunskyy, VM Hatfield, DL Gladyshev, VN AF Labunskyy, Vyacheslav M. Hatfield, Dolph L. Gladyshev, Vadim N. TI Impact of selenium and selenoproteins on regulation of glucose homeostasis and insulin sensitivity in mice SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Labunskyy, Vyacheslav M.; Gladyshev, Vadim N.] Univ Nebraska, Dept Biochem, Lincoln, NE 68583 USA. [Hatfield, Dolph L.] NCI, Lab Canc Prevent, NIH, Bethesda, MD 20892 USA. RI Gladyshev, Vadim/A-9894-2013 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806524 ER PT J AU Leung, WH Biesova, Z Bolland, S AF Leung, Wai-Hang Biesova, Zuzana Bolland, Silvia TI The inositol phosphatase SHIP negatively regulates late stage B-cell development and class switch recombination SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Leung, Wai-Hang; Biesova, Zuzana; Bolland, Silvia] NIAID, Immunogenet Lab, NIH, Rockville, MD 20852 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467804221 ER PT J AU Li, DY Isenberg, JS Pendrak, ML Roberts, DD AF Li, Dayan Isenberg, Jeff S. Pendrak, Michael L. Roberts, David D. TI Quantitative regulation of gene expression of human endothelial tumor markers by thrombospondin-1 and nitric oxide crosstalk SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Li, Dayan] Harvard Univ, Cambridge, MA 02138 USA. [Li, Dayan; Isenberg, Jeff S.; Pendrak, Michael L.; Roberts, David D.] NCI, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467805363 ER PT J AU Li, JX Rice, KC France, CP AF Li, Jun-Xu Rice, Kenner C. France, Charles P. TI Apparent pA2 analysis of 5-HT2A receptor antagonists in rhesus monkeys discriminating DOM SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Li, Jun-Xu; France, Charles P.] Univ Texas Hlth Sci Ctr San Antonio, Dept Pharmacol, San Antonio, TX 78229 USA. [Rice, Kenner C.] NIDA, Lab Med Chem, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802188 ER PT J AU Li, TW Santockyte, R Yu, SQ Yang, DCH Chock, PB AF Li, Tianwei Santockyte, Rasa Yu, Shiqin Yang, David C. H. Chock, P. Boon TI Overexpression of FAT10 upregulates p53 transcriptional activity SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Li, Tianwei; Yu, Shiqin; Chock, P. Boon] NHLBI, Bethesda, MD 20892 USA. [Santockyte, Rasa; Yang, David C. H.] Georgetown Univ, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467804319 ER PT J AU Li, WQ Hixon, J Durum, S AF Li, Wenqing Hixon, Julie Durum, Scott TI Interleukin (IL)-7 promotes T-cell survival by stabilization of Mcl-1 SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Li, Wenqing; Hixon, Julie; Durum, Scott] NCI, LMI, Frederick, MD 21701 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467803097 ER PT J AU Li, WQ Guszczynski, T Xiao, Z Veenstra, T Durum, S AF Li, Wenqing Guszczynski, T. Xiao, Z. Veenstra, T. Durum, S. TI Interleukin (IL)-7 inactivates pro-apoptotic protein Bim at the posttranslational level in association with peripheral T-cell survival SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Li, Wenqing; Durum, S.] NCI, LMI, Frederick, MD 21701 USA. [Guszczynski, T.] NCI, Prot Chem Core, Lab Cell & Dev Sig, Frederick, MD 21701 USA. [Xiao, Z.; Veenstra, T.] SAIC Frederick, Lab Prote & Analyt Tech, Frederick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467803076 ER PT J AU Li, XR AF Li, Xuri TI VEGF-B is an apoptosis inhibitor via suppression of BH3-only protein gene SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Li, Xuri] NEI, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467809331 ER PT J AU Liao, MJ Zhang, Y Dufau, ML AF Liao, Mingjuan Zhang, Ying Dufau, Maria L. TI PKC alpha-Induced Derepression of the Human Luteinizing Hormone Receptor (LHR) through ERK-Mediated Sp1 Phosphorylation SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Liao, Mingjuan; Zhang, Ying; Dufau, Maria L.] NICHD, ERRB, PDEGEN, NIH, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801422 ER PT J AU Limmon, GV McCann, KL Ducharme, DM Imani, F AF Limmon, Gino V. McCann, Kelly L. Ducharme, Danica M. Imani, Farhad TI Comparative analysis of genes induced by respiratory syncytial virus and dsRNA in primary human bronchial epithelial cells SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Limmon, Gino V.; McCann, Kelly L.; Ducharme, Danica M.; Imani, Farhad] NIEHS, LRB, NIH, Res Triangle Pk, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 5 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467807420 ER PT J AU Lu, JH Marnell, LL Mold, C Du Clos, TW Sun, PD AF Lu, Jinghua Marnell, Lorraine L. Mold, Carolyn Du Clos, Terry W. Sun, Peter D. TI Structure of SAP Bound to Fc gamma RIIa Suggests the Regulation of Inflammation by Pentraxins SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Lu, Jinghua; Sun, Peter D.] NIAID, Immunogenet Lab, NIH, Rockville, MD 20852 USA. [Marnell, Lorraine L.; Mold, Carolyn; Du Clos, Terry W.] Univ New Mexico, Dept Internal Med, Albuquerque, NM 87131 USA. [Marnell, Lorraine L.; Mold, Carolyn; Du Clos, Terry W.] Univ New Mexico, Dept Mol Genet & Microbiol, Albuquerque, NM 87131 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700132 ER PT J AU Lu, TY Kim, YC Andersson, J Shevach, EM AF Lu, Tangying (Lily) Kim, Yong Chan Andersson, John Shevach, Ethan M. TI Antigen-specific TGF-beta-induced regulatory T cells modulate mouse splenic dendritic cell function SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Lu, Tangying (Lily); Kim, Yong Chan; Andersson, John; Shevach, Ethan M.] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806234 ER PT J AU Lu, ZP Sack, MN AF Lu, Zhongping Sack, Michael N. TI ATF-1 is a hypoxia responsive transcriptional activator of UCP3 SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Lu, Zhongping; Sack, Michael N.] NHLBI, Translat Med Branch, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700173 ER PT J AU Luo, S Levine, RL AF Luo, Shen Levine, Rodney L. TI Testing The Hypothesis That "Methionine Residues In Proteins Are Antioxidants" SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Luo, Shen; Levine, Rodney L.] NHLBI, Biochem Lab, Bethesda, MD 20892 USA. RI Levine, Rodney/D-9885-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467807791 ER PT J AU Madala, SK Hodges, M Shweta, T Virgilio, B Urban, JF Keane-Myers, A AF Madala, Satish Kumar Hodges, Marcus Shweta, Trivedi Virgilio, Bundoc Urban, Joseph F., Jr. Keane-Myers, Andrea TI The parasitic nematode Ascaris suum secretes a hemoglobin that scavenges host derived free radicals and activates dendritic cells through TLR4 SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Madala, Satish Kumar; Hodges, Marcus; Shweta, Trivedi; Virgilio, Bundoc; Keane-Myers, Andrea] NIAID, Lab Allerg Dis, NIH, Rockville, MD USA. [Urban, Joseph F., Jr.] USDA, Diet Genom & Immunol Lab, Beltsville, MD 20705 USA. NR 0 TC 0 Z9 0 U1 3 U2 4 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806796 ER PT J AU Mage, RG AF Mage, Rose G. TI Rabbit genome sequencing update: genes of immunological interest found in the 2x genome assemblies, ENCODE, and the 7x trace archive SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Mage, Rose G.] NIAID, MIS, Immunol Lab, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700069 ER PT J AU Matthews, AGW Kuo, AJ Ramon-Maiques, S Han, SM Champagne, KS Kutateladze, TG Yang, W Gozani, O Oettinger, MA AF Matthews, Adam Goon Wai Kuo, Alex J. Ramon-Maiques, Santiago Han, Sunmi Champagne, Karen S. Kutateladze, Tatiana G. Yang, Wei Gozani, Or Oettinger, Marjorie A. TI RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Matthews, Adam Goon Wai; Han, Sunmi; Oettinger, Marjorie A.] Harvard Univ, Sch Med, MGH Dept Mol Biol, Boston, MA USA. [Kuo, Alex J.; Gozani, Or] Stanford Univ, Dept Biol Sci, Stanford, CA 94305 USA. [Ramon-Maiques, Santiago; Yang, Wei] NIDDKD, Mol Biol Lab, NIH, Bethesda, MD 20892 USA. [Champagne, Karen S.; Kutateladze, Tatiana G.] Univ Colorado, Hlth Sci Ctr, Aurora, CO USA. NR 0 TC 0 Z9 0 U1 10 U2 10 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802229 ER PT J AU Mazariegos, M Westcott, J Krebs, NF Goco, N Gonzalez, M Kraushaar, H Wright, L Solomons, NW Hambidge, KM AF Mazariegos, Manolo Westcott, Jamie Krebs, Nancy F. Goco, Norman Gonzalez, Michelle Kraushaar, Hatai Wright, Linda Solomons, Noel W. Hambidge, K. Michael TI Complementary feeding practices in contemporary Guatemalan infants: zinc (Zn) and iron (Fe) intakes SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Westcott, Jamie; Krebs, Nancy F.; Kraushaar, Hatai; Hambidge, K. Michael] Univ Colorado, Denver, CO 80202 USA. [Mazariegos, Manolo; Solomons, Noel W.] CeSSIAM, Guatemala City, Guatemala. [Goco, Norman] RTI Int, Stats Epi, Res Triangle Pk, NC USA. [Gonzalez, Michelle] FANCAP INCAP, Guatemala City, Guatemala. [Wright, Linda] NICHD, Ctr Res Mothers & Children, NIH, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467805387 ER PT J AU Mentink-Kane, MM Wynn, TA Cheever, A AF Mentink-Kane, Margaret M. Wynn, Thomas A. Cheever, Allen TI Accelerated fibrosis in the combined absence of Interleukin-13 regulatory molecules: IL-13 receptor alpha 2, IL-10 and IL-12 SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Mentink-Kane, Margaret M.; Wynn, Thomas A.; Cheever, Allen] NIAID, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700843 ER PT J AU Meyer-Manlapat, AK Segal, DM AF Meyer-Manlapat, Anna Katrina Segal, David M. TI Mast cells are critical for the degranulation-induced shift from Th1 to Th2 immune responses in vivo SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Meyer-Manlapat, Anna Katrina; Segal, David M.] NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467804608 ER PT J AU Miletic, AV Anzelon-Mills, AN Mills, DM Omori, SA Pedersen, IM Ravetch, JV Bolland, S Rickert, RC AF Miletic, Ana V. Anzelon-Mills, Amy N. Mills, David M. Omori, Sidne A. Pedersen, Irene M. Ravetch, Jeffrey V. Bolland, Silvia Rickert, Robert C. TI Coordinate suppression of B cell lymphoma by PTEN and SHIP SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Miletic, Ana V.; Anzelon-Mills, Amy N.; Mills, David M.; Omori, Sidne A.; Rickert, Robert C.] Burnham Inst Med Res, Infect & Inflammatory Dis Ctr, Program Inflammatory Dis Res, La Jolla, CA USA. [Pedersen, Irene M.] Univ Calif San Diego, Dept Mol Biol, San Diego, CA 92103 USA. [Ravetch, Jeffrey V.] Rockefeller Univ, Lab Mol Genet & Immunol, New York, NY 10021 USA. [Bolland, Silvia] NIAID, Immunogenet Lab, Rockville, MD 20852 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467808677 ER PT J AU Minor, RAC Croom, B Imani, F AF Minor, Radiah Ann Corn Croom, Brittany Imani, Farhad TI Anti RSV immunoglobulin isotype selection requires dsRNA-activated protein kinase (PKR) SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Minor, Radiah Ann Corn; Imani, Farhad] NIEHS, LRB, NIH, Res Triangle Pk, NC USA. [Croom, Brittany] UNC, Chapel Hill, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467807196 ER PT J AU Minor, R Percival, S de Cabo, R AF Minor, Robin Percival, Susan de Cabo, Rafael TI Dietary restriction and induced tumorigenesis in mice with altered hypothalamic appetite regulation SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Minor, Robin; de Cabo, Rafael] NIA, Lab Expt Gerontol, Baltimore, MD 21224 USA. [Minor, Robin; Percival, Susan] Univ Florida, Dept Food Sci & Human Nutr, Gainesville, FL 32611 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467807020 ER PT J AU Moaddel, R Oliveira, R Kimura, T Hyppolite, P Juhaszova, M Bernier, M Wainer, I AF Moaddel, Ruin Oliveira, Regina Kimura, Tomoko Hyppolite, Patrick Juhaszova, Magdalena Bernier, Michel Wainer, Irving TI Initial synthesis and characterization of an alpha7 nicotinic receptor cellular membrane affinity chromatography column: Effect of receptor subtype and cell type SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Moaddel, Ruin; Kimura, Tomoko; Hyppolite, Patrick; Juhaszova, Magdalena; Bernier, Michel; Wainer, Irving] NIA, Lab Clin Invest, NIH, Baltimore, MD 21224 USA. [Oliveira, Regina] Univ Fed Sao Carlos, Dept Quim, BR-13560 Sao Carlos, Brazil. NR 0 TC 0 Z9 0 U1 1 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467804635 ER PT J AU Moller, HB Hoffert, JD Rutzler, M Praetorius, J Knepper, MA Fenton, RA AF Moller, Hanne B. Hoffert, Jason D. Rutzler, Michael Praetorius, Jeppe Knepper, Mark A. Fenton, Robert A. TI Phosphorylation of Serine-256 is essential for downstream polyphosphorylation of AQP2 SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Moller, Hanne B.; Rutzler, Michael; Praetorius, Jeppe; Fenton, Robert A.] Univ Aarhus, Water & Salt Res Ctr, Aarhus, Denmark. [Hoffert, Jason D.; Knepper, Mark A.] NHLBI, LKEM, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467805645 ER PT J AU Mukhopadhyay, P Rajesh, M Yoshihiro, K Hawkins, BJ Madesh, M Pacher, P AF Mukhopadhyay, Partha Rajesh, Mohanraj Yoshihiro, Kashiwaya Hawkins, Brian J. Madesh, Muniswamy Pacher, Pal TI Simultaneous quantitative detection of mitochondrial superoxide production and apoptosis in live cells SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Mukhopadhyay, Partha; Rajesh, Mohanraj; Pacher, Pal] NIH, SOSTI LPS, Rockville, MD USA. [Yoshihiro, Kashiwaya] NIH, LMC, Rockville, MD USA. [Hawkins, Brian J.; Madesh, Muniswamy] Univ Penn, Dept Canc Biol, Philadelphia, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802244 ER PT J AU Mukoyama, Y AF Mukoyama, Yosuke TI Neuro-vascular interaction during mouse development SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Mukoyama, Yosuke] NHLBI, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800509 ER PT J AU Nagata, S Ise, T Pastan, I AF Nagata, Satoshi Ise, Tomoko Pastan, Ira TI IL-2 non-responsive subset of human natural regulatory T cells expresses Fc receptor-like 3 protein SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Nagata, Satoshi; Ise, Tomoko] Sanford Res USD, Canc Biol Res Ctr, Sioux Falls, SD USA. [Nagata, Satoshi; Ise, Tomoko; Pastan, Ira] NCI, Mol Biol Lab, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700065 ER PT J AU Nakae, H Hanyu, O Fuda, H Strott, CA AF Nakae, Hanako Hanyu, Osamu Fuda, Hirotoshi Strott, Charles A. TI Novel role of cholesterol sulfate in gene regulation during skin development SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Nakae, Hanako; Fuda, Hirotoshi; Strott, Charles A.] NICHD, NIH, Bethesda, MD USA. [Hanyu, Osamu] Niigata Univ, Grad Sch Med & Dent Sci, Chuo Ku, Niigata, Japan. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800090 ER PT J AU Nayeem, MA Poloyac, SM Falck, JR Zeldin, DC Ledent, C Mustafa, SJ AF Nayeem, Mohammed A. Poloyac, Samuel M. Falck, John R. Zeldin, Darryl C. Ledent, Catherine Mustafa, S. Jamal TI Role of CYP2C generated metabolites in adenosine-mediated relaxation using A2A AR-/- mice SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Nayeem, Mohammed A.; Mustafa, S. Jamal] W Virginia Univ, Morgantown, WV 26506 USA. [Poloyac, Samuel M.] Univ Pittsburgh, Pittsburgh, PA USA. [Falck, John R.] UTSWMC, Dallas, TX USA. [Zeldin, Darryl C.] NIEHS, NIH, Res Triangle Pk, NC USA. [Ledent, Catherine] Univ Libre Brussels, Brussels, Belgium. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806251 ER PT J AU Negus, SS Rice, KC AF Negus, S. Stevens Rice, Kenner C. TI Role of delta receptor efficacy as a determinant of delta/mu opioid interactions in rhesus monkeys SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Negus, S. Stevens] Virginia Commonwealth Univ, Richmond, VA USA. [Rice, Kenner C.] NIAAA, Chem Biol Res Branch, NIDA, Rockville, MD 20852 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800033 ER PT J AU Neuman, KC AF Neuman, Keir Cajal TI Untwisting and untangling DNA: Symmetry breaking by topoisomerases SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Neuman, Keir Cajal] NHLBI, NIH, Bethesda, MD 20892 USA. RI Neuman, Keir/F-7400-2011 OI Neuman, Keir/0000-0002-0863-5671 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802394 ER PT J AU Nielsen, J Hoffert, J Knepper, MA Nielsen, S Fenton, RA AF Nielsen, Jakob Hoffert, Jason Knepper, Mark A. Nielsen, Soren Fenton, Robert A. TI Proteomic analysis of lithium induced changes in rat inner medulla collecting duct SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Nielsen, Jakob; Nielsen, Soren; Fenton, Robert A.] Univ Aarhus, Water & Salt Res Ctr, Aarhus, Denmark. [Hoffert, Jason; Knepper, Mark A.] NHLBI, LKEM, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467804292 ER PT J AU Olkhanud, PB Baatar, D Biragyn, A AF Olkhanud, Purevdorj B. Baatar, Dolgor Biragyn, Arya TI Immune cells facilitate lung metastasis of breast cancer cells SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Olkhanud, Purevdorj B.; Baatar, Dolgor; Biragyn, Arya] NIA, LI, Baltimore, MD 21224 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467807382 ER PT J AU Olsen, RJ Sitkiewicz, I Ayeras, A Tart, A Lei, BF Blasdel, T Humbird, T Beres, S Green, N Cagle, P Montgomery, C Whitney, A DeLeo, F Musser, JM AF Olsen, Randall J. Sitkiewicz, Izabela Ayeras, Ara Tart, Anne Lei, Benfang Blasdel, Terry Humbird, Tammy Beres, Stephen Green, Nicole Cagle, Philip Montgomery, Charles Whitney, Adeline DeLeo, Frank Musser, James M. TI A Naturally Occurring Single Nucleotide Mutation Significantly Impairs Necrotizing Fasciitis ("Flesh Eating") Capacity of Group A Streptococcus (GAS) SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Olsen, Randall J.; Sitkiewicz, Izabela; Ayeras, Ara; Tart, Anne; Beres, Stephen; Green, Nicole; Cagle, Philip; Musser, James M.] Methodist Hosp, Res Inst, Houston, TX 77030 USA. [Lei, Benfang] Montana State Univ, Bozeman, MT 59717 USA. [Blasdel, Terry; Humbird, Tammy] Univ Houston, Houston, TX USA. [Montgomery, Charles] Compath, Conroe, TX USA. [Whitney, Adeline; DeLeo, Frank] NIAID, Pathogen Host Cell Biol Sect, Hamilton, MT USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700116 ER PT J AU Oppermann, M Lorenz, J Wall, S Schnermann, J AF Oppermann, Mona Lorenz, John Wall, Susan Schnermann, Jurgen TI Impaired autoregulation and TGF responses in NKCC1-deficient mice SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Oppermann, Mona; Schnermann, Jurgen] NIDDK, NIH, Bethesda, MD USA. [Oppermann, Mona] Univ Erlangen Nurnberg, D-91054 Erlangen, Germany. [Lorenz, John] Univ Cincinnati, Cincinnati, OH USA. [Wall, Susan] Emory Univ, Atlanta, GA 30322 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806717 ER PT J AU Pacher, P Mukhopadhyay, P Rajesh, M Batkai, S Kunos, G AF Pacher, Pal Mukhopadhyay, Partha Rajesh, Mohanraj Batkai, Sandor Kunos, George TI Role of CB2 cannabinoid receptors in interplay between endothelium and inflammatory cells: implications for ischemia-reperfusion injury and atherosclerosis SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Pacher, Pal; Mukhopadhyay, Partha; Rajesh, Mohanraj] NIAAA, SOSTI, Lab Physiol Studies, NIH, Rockville, MD 20852 USA. RI Batkai, Sandor/H-7983-2014 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802387 ER PT J AU Pacher, P Mukhopadhyay, P Rajesh, M Batkai, S Hasko, G Szabo, C AF Pacher, Pal Mukhopadhyay, Partha Rajesh, Mohanraj Batkai, Sandor Hasko, Gyoergy Szabo, Csaba TI Interplay of superoxide, nitric oxide and peroxynitrite in doxorubicin-induced cell death SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Pacher, Pal; Mukhopadhyay, Partha; Rajesh, Mohanraj; Batkai, Sandor] NIAAA, SOSTI, Lab Physiol Studies, NIH, Rockville, MD 20852 USA. [Hasko, Gyoergy] UMDNJ New Jersey Med Sch, Dept Surg, Newark, MD USA. RI Batkai, Sandor/H-7983-2014 NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802383 ER PT J AU Pacher, P Mukhopadhyay, P Batkai, S Rajesh, M Hasko, G Kunos, G AF Pacher, Pal Mukhopadhyay, Partha Batkai, Sandor Rajesh, Mohanraj Hasko, Gyoergy Kunos, George TI Cannabinoid receptor-1 deletion or inhibition protects against doxorubicin-induced cardiotoxicity SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Pacher, Pal; Mukhopadhyay, Partha; Rajesh, Mohanraj] NIAAA, SOSTI, Lab Physiol Studies, NIH, Rockville, MD 20852 USA. [Hasko, Gyoergy] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Surg, Newark, NJ 07103 USA. RI Batkai, Sandor/H-7983-2014 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802377 ER PT J AU Padilla, PI Uhart, M Peculis, B Moss, J Vaughan, M AF Padilla, Philip Ian Uhart, Marina Peculis, Brenda Moss, Joel Vaughan, Martha TI Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) associates with nucleolin and U3 snoRNA in HepG2 cell nuclei SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Padilla, Philip Ian; Uhart, Marina; Moss, Joel; Vaughan, Martha] NHLBI, NIH, Bethesda, MD 20892 USA. [Peculis, Brenda] Univ Missouri, Dept Biochem, Columbia, MO USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806861 ER PT J AU Pandiyan, P Lenardo, M AF Pandiyan, Pushpa Lenardo, Michael TI CD4+CD25+Foxp3+regulatory T cells induce cytokine deprivation apoptosis of the effector CD4+T cells SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Pandiyan, Pushpa; Lenardo, Michael] NIAID, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800674 ER PT J AU Parent, CA AF Parent, Carole A. TI Molecular Insight into Chemotactic Signaling SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Parent, Carole A.] NCI, Cellular & Mol Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801655 ER PT J AU Park, H Simon, A Maddipati, R Bulua, A Komarow, H Kastner, D Siegel, RM AF Park, Heiyoung Simon, Anna Maddipati, Ravikanth Bulua, Ariel Komarow, Hirsh Kastner, Daniel Siegel, Richard M. TI Intracellular accumulation of mutant TNFR1 potentiates MAP-Kinase signaling and innate immune responses in the TNF-receptor associated Periodic Syndrome (TRAPS) SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Park, Heiyoung; Simon, Anna; Maddipati, Ravikanth; Bulua, Ariel; Komarow, Hirsh; Kastner, Daniel; Siegel, Richard M.] NIAMS, NIH, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467804286 ER PT J AU Park, O Jeong, WI Gao, B AF Park, Ogyi Jeong, Won-Il Gao, Bin TI Type I Natural Killer T (iNKT) Cells Regulate Inflammatory Immune Response in Mice Liver Injury Induced by CCl4 SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Park, Ogyi; Jeong, Won-Il; Gao, Bin] NIAAA, Sect Liver Biol, LPS, NIH, Rockville, MD 20852 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806740 ER PT J AU Pawelczyk, E Jordan, EK Johnson-Barelo, J Smith, M Chaudhry, A Frank, JA AF Pawelczyk, Edyta Jordan, Eleine Kay Johnson-Barelo, Janna Smith, Melissa Chaudhry, Aneeka Frank, Joseph Alan TI In vivo Uptake of BrdU, GFP and Iron Oxide Nanoparticles by Local Tissue Macrophages from Labeled Stem Cells. Implications for Cell Transplantation SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Pawelczyk, Edyta; Jordan, Eleine Kay; Johnson-Barelo, Janna; Smith, Melissa; Chaudhry, Aneeka; Frank, Joseph Alan] NIH, Expt Neuroimaging Sect, Ctr Clin, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806572 ER PT J AU Pesce, JT Cheever, AW Ramalingam, TR Wilson, MS Mentink-Kane, MM El Kasmi, KC Smith, AM Murray, PJ Wynn, TA AF Pesce, John T. Cheever, Allen W. Ramalingam, Thirumalai R. Wilson, Mark S. Mentink-Kane, Margaret M. El Kasmi, Karim C. Smith, Amber M. Murray, Peter J. Wynn, Thomas A. TI Macrophage/neutrophil specific Arginase-1 is a critical survival factor and regulator of liver fibrosis during Schistosoma mansoni infection SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Pesce, John T.; Ramalingam, Thirumalai R.; Wilson, Mark S.; Mentink-Kane, Margaret M.; Wynn, Thomas A.] NIAID, NIH, LPD, Bethesda, MD 20892 USA. [El Kasmi, Karim C.] Univ Colorado, Hlth Sci Ctr, Denver, CO USA. [Cheever, Allen W.] BRI, Rockville, MD USA. [Smith, Amber M.; Murray, Peter J.] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467804039 ER PT J AU Peterson, ME Long, EO AF Peterson, Mary E. Long, Eric O. TI Tyrosine phosphorylation of an adapter protein induced by NK cell inhibitory receptor contributes to inhibition of cytotoxicity SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Peterson, Mary E.; Long, Eric O.] NIAID, LIG, NIH, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806243 ER PT J AU Phang, JM Pandhare, J Borchert, G Donald, SP Liu, YM AF Phang, James Ming Pandhare, Jui Borchert, Greg Donald, Steven P. Liu, Yongmin TI Pro line - A Critical "Stress Substrate" for Bioenergetics and Programmed Cell Death SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Phang, James Ming; Pandhare, Jui; Donald, Steven P.] NCI Frederick, Comparat Carcinogenesis Lab, NIH, Frederick, MD USA. [Borchert, Greg; Liu, Yongmin] SAIC Frederick, Basic Res Program, Frederick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800315 ER PT J AU Pietroni, V Radoja, N Rivera, Y Stimpson, SJ Anderson, DE Blumenberg, M Morasso, MI AF Pietroni, Valentina Radoja, Nadezda Rivera, Yesenia Stimpson, Sarah Jo Anderson, David Eric Blumenberg, Miroslav Morasso, Maria I. TI Regulation of CDKN1A expression in keratinocytes by Distal-less 3 SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Pietroni, Valentina; Radoja, Nadezda; Rivera, Yesenia; Stimpson, Sarah Jo; Morasso, Maria I.] DSBU, Bethesda, MD USA. [Anderson, David Eric] NIDDK, NIH, Bethesda, MD USA. [Blumenberg, Miroslav] NYU, Dept Dermatol & Biochem, New York, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800679 ER PT J AU Pillai, VC Chen, YQ Crumley, J Bazinet, RP Rapoport, SI Weis, MT AF Pillai, Venkateswaran C. Chen, Yi Qing Crumley, Jason Bazinet, Richard P. Rapoport, Stanley I. Weis, Margaret T. TI Triacsin C is a time dependent inhibitor of Long Chain Fatty Acyl CoA Synthetase (Acsl) in endothelial cells SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Pillai, Venkateswaran C.; Chen, Yi Qing; Crumley, Jason; Weis, Margaret T.] Texas Tech Univ, Hlth Sci Ctr, Amarillo, TX USA. [Bazinet, Richard P.] Univ Toronto, Toronto, ON, Canada. [Rapoport, Stanley I.] NIA, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 1 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467805081 ER PT J AU Pinto, LA Kemp, TJ Hildesheim, A Garcia-Pineres, A Williams, MC Rodriguez, AC Schiffman, M Burk, R Freer, E Bonilla, J Herrero, R AF Pinto, Ligia A. Kemp, Troy J. Hildesheim, Allan Garcia-Pineres, Alfonso Williams, Marcus C. Cecilia Rodriguez, Ana Schiffman, Mark Burk, Robert Freer, Enrique Bonilla, Jose Herrero, Rolando TI Increased Circulating Proinflammatory Cytokines in Older Women with Persistent HPV Infection SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Pinto, Ligia A.; Kemp, Troy J.; Garcia-Pineres, Alfonso; Williams, Marcus C.] NCI, HPV Immunol Lab, SAIC Frederick Inc, Frederick, MD 21701 USA. [Hildesheim, Allan; Schiffman, Mark] NIH, DCEG, Bethesda, MD 20892 USA. [Cecilia Rodriguez, Ana; Herrero, Rolando] PEG, Guanacaste, Costa Rica. [Burk, Robert] Albert Einstein Coll Med, Bronx, NY 10467 USA. [Freer, Enrique; Bonilla, Jose] UCR, San Jose, Costa Rica. RI Hildesheim, Allan/B-9760-2015 OI Hildesheim, Allan/0000-0003-0257-2363 NR 0 TC 0 Z9 0 U1 0 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806135 ER PT J AU Pinto, LA Garcia-Pineres, AJ Hildesheim, A Dodd, L Kemp, TJ Yang, J Fullmer, B Harro, C Lowy, DR Schiller, JT Lempicki, RA AF Pinto, Ligia A. Garcia-Pineres, Alfonso J. Hildesheim, Allan Dodd, Lori Kemp, Troy J. Yang, Jun Fullmer, Brandie Harro, Clayton Lowy, Douglas R. Schiller, John T. Lempicki, Richard A. TI Gene expression patterns induced by HPV-16 L1 VLP in leukocytes from vaccine recipients SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Pinto, Ligia A.; Garcia-Pineres, Alfonso J.; Kemp, Troy J.] NCI, HPV Immunol Lab, SAIC Frederick Inc, Frederick, MD 21701 USA. [Hildesheim, Allan] NIH, DCEG, Bethesda, MD USA. [Dodd, Lori] NIH, DCTD, Bethesda, MD USA. [Lowy, Douglas R.; Schiller, John T.] NIH, CCR, Bethesda, MD USA. [Harro, Clayton] JHU, Baltimore, MD USA. RI Lempicki, Richard/E-1844-2012; Hildesheim, Allan/B-9760-2015 OI Lempicki, Richard/0000-0002-7059-409X; Hildesheim, Allan/0000-0003-0257-2363 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806061 ER PT J AU Pisitkun, P Deane, JA Bolland, S AF Pisitkun, Prapaporn Deane, Jonathan A. Bolland, Silvia TI CD40L is crucial for the development of autoimmunity induced by TLR7 overexpression SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Pisitkun, Prapaporn; Deane, Jonathan A.; Bolland, Silvia] NIAID, LIG, AFGS, NIH, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467803315 ER PT J AU Pisitkun, T Jacob, V Yu, MJ Chou, CL Knepper, MA AF Pisitkun, Trairak Jacob, Vinitha Yu, Ming-Jiun Chou, Chung-Lin Knepper, Mark A. TI Vasopressin Activates Akt1 Through PI-3K in Rat Inner Medullary Collecting Duct (IMCD) SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Pisitkun, Trairak; Jacob, Vinitha; Yu, Ming-Jiun; Chou, Chung-Lin; Knepper, Mark A.] NHLBI, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802471 ER PT J AU Pluznick, JL Zou, DJ Zhang, X Yan, Q Rodriguez-Gil, D Eisner, C Wells, EK Greer, C Schnermann, J Wang, T Firestein, S Caplan, MJ AF Pluznick, J. L. Zou, D. J. Zhang, X. Yan, Q. Rodriguez-Gil, D. Eisner, C. Wells, E. K. Greer, C. Schnermann, J. Wang, T. Firestein, S. Caplan, M. J. TI The olfactory isoform of adenylyl cyclase (AC3) in the renal macula densa serves as a key regulator of glomerular filtration rate SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Pluznick, J. L.; Yan, Q.; Rodriguez-Gil, D.; Wells, E. K.; Greer, C.; Wang, T.; Caplan, M. J.] Yale Univ, Sch Med, New Haven, CT USA. [Zou, D. J.; Zhang, X.; Firestein, S.] Columbia Univ, New York, NY USA. [Eisner, C.; Schnermann, J.] NIDDK, Kidney Dis Sect, NIH, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467804507 ER PT J AU Pries, AR Cornelissen, AJM Sloot, AA Dreher, M Hinkeldey, M Hopfner, M Dewhirst, MW Secomb, TW AF Pries, Axel R. Cornelissen, Annemiek J. M. Sloot, Anouk A. Dreher, Matthew Hinkeldey, Marlene Hoepfner, Michael Dewhirst, Mark W. Secomb, Timothy W. TI Changed microvascular adaptation characteristics may explain heterogeneity and hypoxia of tumor perfusion SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Pries, Axel R.; Cornelissen, Annemiek J. M.; Hinkeldey, Marlene; Hoepfner, Michael] Charite, Dept Physiol CBF, Berlin, Germany. [Pries, Axel R.] DHZB Berlin, Berlin, Germany. [Cornelissen, Annemiek J. M.] Univ Paris Diderot, Paris, France. [Sloot, Anouk A.] Delft Univ Technol, Dept Med Technol, Delft, Netherlands. [Dreher, Matthew] NCI, Radiol Branch, NIH, Bethesda, MD 20892 USA. [Dewhirst, Mark W.] Duke Univ, Med Ctr, Durham, NC USA. [Secomb, Timothy W.] Univ Arizona, Dept Physiol, Tucson, AZ USA. NR 0 TC 0 Z9 0 U1 0 U2 5 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467805650 ER PT J AU Punkosdy, G Ahmed, R Shevach, E AF Punkosdy, George Ahmed, Rafi Shevach, Ethan TI Marked Expansion of Foxp3+, Vbeta5+Regulatory T cells during Chronic Lymphocytic Choriomeningitis Virus (LCMV) Infection SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Punkosdy, George; Shevach, Ethan] NIAID, NIH, Bethesda, MD 20892 USA. [Ahmed, Rafi] Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA USA. [Ahmed, Rafi] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806656 ER PT J AU Putnik, P Calle, MC Fernandez, ML Damio, G Segura-Perez, S Vega-Lopez, S Chhabra, J Perez-Escamilla, R AF Putnik, Predrag Calle, Mariana C. Fernandez, Maria-Luz Damio, Grace Segura-Perez, Sofia Vega-Lopez, Sonia Chhabra, Jyoti Perez-Escamilla, Rafael TI Influence of Acculturation on Food Label Use and Nutrient Intakes among Latinos Participating In the DIALBEST Trial: Preliminary Results SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Putnik, Predrag; Calle, Mariana C.; Fernandez, Maria-Luz; Perez-Escamilla, Rafael] Univ Connecticut, Storrs, CT USA. [Damio, Grace; Segura-Perez, Sofia; Vega-Lopez, Sonia] Hispan Hlth Council Inc, Hartford, CT USA. [Chhabra, Jyoti] Hartford Hosp, Hartford, CT 06115 USA. [Perez-Escamilla, Rafael] Latino Hlth Dispar NIH EXPORT Ctr, Storrs, CT USA. RI Putnik, Predrag/B-6495-2016 OI Putnik, Predrag/0000-0003-0342-6114 NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802802 ER PT J AU Rafii-El-Idrissi, MB McCausland, M Su, HP Singh, K Hoffmann, J Davies, DH Felgner, P Head, S Sette, A Garboczi, D Crotty, S AF Rafii-El-Idrissi, Mohammed Benhnia McCausland, M. Su, Hua-Poo Singh, K. Hoffmann, J. Davies, D. Huw Felgner, P. Head, S. Sette, A. Garboczi, D. Crotty, S. TI Diversity of neutralizing antibody responses in human smallpox vaccinees SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Rafii-El-Idrissi, Mohammed Benhnia; McCausland, M.; Sette, A.; Crotty, S.] LIAI, Div Vaccine Discovery, La Jolla, CA USA. [Su, Hua-Poo; Singh, K.; Garboczi, D.] NIH, Immunogenet Lab, Rockville, MD USA. [Hoffmann, J.; Head, S.] Scripps Res Inst, DNA Array Core Facil, La Jolla, CA 92037 USA. [Davies, D. Huw; Felgner, P.] UC Irvine, Dept Med, Irvine, CA USA. NR 0 TC 0 Z9 0 U1 2 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467809012 ER PT J AU Raghuram, V Yang, Y Yaemsiri, S AF Raghuram, Viswanathan Yang, Yu Yaemsiri, Sirin TI Physiological role of NHERF family proteins in the regulation of CFTR SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Raghuram, Viswanathan; Yang, Yu; Yaemsiri, Sirin] NHLBI, Lab Kidney & Electrolyte Metab, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467809248 ER PT J AU Rajesh, M Mukhopadhyay, P Batkai, S Huffman, J Csiszar, A Ungvari, Z Chatterjee, S Pacher, P AF Rajesh, Mohanraj Mukhopadhyay, Partha Batkai, Sandor Huffman, John Csiszar, Anna Ungvari, Zoltan Chatterjee, Subroto Pacher, Pal TI CB2 cannabinoid receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Rajesh, Mohanraj; Mukhopadhyay, Partha; Batkai, Sandor; Pacher, Pal] NIH, SOSTI LPS, Rockville, MD USA. [Huffman, John] Clemson Univ, Howard L Hunter Chem Lab, Clemson, SC 29634 USA. [Csiszar, Anna; Ungvari, Zoltan] New York Med Coll, Dept Physiol, Valhalla, NY 10595 USA. [Chatterjee, Subroto] Johns Hopkins Univ, Dept Pediat, Baltimore, MD 21218 USA. RI Batkai, Sandor/H-7983-2014 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802358 ER PT J AU Rajesh, M Mukhopadhyay, P Godlewski, G Batkai, S Pacher, P AF Rajesh, Mohanraj Mukhopadhyay, Partha Godlewski, Grzegorz Batkai, Sandor Pacher, Pal TI Poly(ADP-ribose)polymerase inhibition decreases angiogenesis. SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Rajesh, Mohanraj; Mukhopadhyay, Partha; Godlewski, Grzegorz; Batkai, Sandor; Pacher, Pal] NIH, SOSTI LPS, Rockville, MD USA. RI Batkai, Sandor/H-7983-2014 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802351 ER PT J AU Rajesh, M Mukhopadhyay, P Batkai, S Hasko, G Huffman, J Mackie, K Pacher, P AF Rajesh, Mohanraj Mukhopadhyay, Partha Batkai, Sandor Hasko, Gyoergy Huffman, John Mackie, Ken Pacher, Pal TI CB2 receptor agonists attenuate TNF-alpha induced human vascular smooth muscle cell proliferation and migration SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Rajesh, Mohanraj; Mukhopadhyay, Partha; Batkai, Sandor; Pacher, Pal] NIH, SOSTI LPS, Rockville, MD USA. [Hasko, Gyoergy] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Surg, Newark, NJ 07103 USA. [Huffman, John] Clemson Univ, Clemson, SC USA. [Mackie, Ken] Indiana Univ, Bloomington, IN 47405 USA. RI Batkai, Sandor/H-7983-2014 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802309 ER PT J AU Ramalingam, TR Pesce, JT Sheikh, FA Cheever, AW Mentink-Kane, MM Wilson, MS Stevens, S Valenzuela, DM Murphy, AJ Yancopoulos, GD Urban, JF Donnelly, RP Wynn, TA AF Ramalingam, Thirumalai Rajan Pesce, John T. Sheikh, Farukh A. Cheever, Allen W. Mentink-Kane, Margaret M. Wilson, Mark S. Stevens, Sean Valenzuela, David M. Murphy, Andrew J. Yancopoulos, George D. Urban, Joeseph F., Jr. Donnelly, Raymond P. Wynn, Thomas A. TI Unique functions of the type II interleukin 4 receptor revealed in mice lacking the interleukin 13 receptor alpha 1 chain SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Ramalingam, Thirumalai Rajan; Pesce, John T.; Mentink-Kane, Margaret M.; Wilson, Mark S.; Wynn, Thomas A.] NIAID, LPD, Bethesda, MD 20892 USA. [Sheikh, Farukh A.; Donnelly, Raymond P.] US FDA, CDER, Bethesda, MD 20014 USA. [Cheever, Allen W.] Biomed Res Inst, Rockville, MD 20852 USA. [Stevens, Sean; Valenzuela, David M.; Murphy, Andrew J.; Yancopoulos, George D.] Regenron, Tarrytown, NY USA. [Urban, Joeseph F., Jr.] USDA, Diet Genom & Immunol Lab, Beltsville, MD 20705 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467804247 ER PT J AU Rand, E Cheruk-Uri, S Bustin, M AF Rand, Eyal Cheruk-Uri, Srujana Bustin, Michael TI High Mobility Group Nucleosome binding protein1 (HMGN1) is a dynamic player in differentiation and gene regulation SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Rand, Eyal; Cheruk-Uri, Srujana; Bustin, Michael] NCI, NIH, Bethesda, MD 20892 USA. RI Bustin, Michael/G-6155-2015 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700064 ER PT J AU Raychaudhuri, S Tsourkas, P Tolar, P AF Raychaudhuri, Subhadip Tsourkas, Phiippos Tolar, Pavel TI Immunological synapse formation modulates affinity discrimination in Bcells SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Raychaudhuri, Subhadip; Tsourkas, Phiippos] Univ Calif Davis, Davis, CA USA. [Tolar, Pavel] NIAID, NIH, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467808772 ER PT J AU Revilleza, MJR Levin, D Mage, MG Teyton, L Robinson, H Shevach, EM Natarajan, K Margulies, DH AF Revilleza, Maria Jamela R. Levin, Ditza Mage, Michael G. Teyton, Luc Robinson, Howard Shevach, Ethan M. Natarajan, Kannan Margulies, David H. TI The X-ray Structure of IAd in Complex with a Self Peptide Offers New Insights Into the Basis of Autoimmune Gastritis (AIG) SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Revilleza, Maria Jamela R.; Mage, Michael G.; Natarajan, Kannan; Margulies, David H.] NIAID, LI, MBS, Bethesda, MD 20892 USA. [Shevach, Ethan M.] NIAID, LI, NIH, Bethesda, MD 20892 USA. [Levin, Ditza] Ort Braude Engn Coll, Biotechnol Engn Dept, Karmiel, Israel. [Teyton, Luc] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA. [Robinson, Howard] Brookhaven Natl Lab, Dept Biol, Upton, NY 11973 USA. RI Margulies, David/H-7089-2013 NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467807481 ER PT J AU Rosemond, E Scarselli, M De Azua, IR Wess, J AF Rosemond, Erica Scarselli, Marco De Azua, Inigo Ruiz Wess, Jurgen TI Identification of a novel protein partner of the M3 muscarinic acetylcholine receptor SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Rosemond, Erica; De Azua, Inigo Ruiz; Wess, Jurgen] NIH NIDDK, Bethesda, MD USA. [Scarselli, Marco] NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700204 ER PT J AU Ryan, JJ Bamstein, B Macey, M Leonard, W Shevach, E Thornton, A Kashyap, M AF Ryan, John J. Bamstein, Brian Macey, Matthew Leonard, Warren Shevach, Ethan Thornton, Angela Kashyap, Mohit TI Regulation of Mast Cell Function by Regulatory T Cells SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Ryan, John J.; Bamstein, Brian; Macey, Matthew] Virginia Commonwealth Univ, Richmond, VA USA. [Leonard, Warren; Shevach, Ethan; Thornton, Angela; Kashyap, Mohit] NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467807082 ER PT J AU Sakthivel, SK Singh, UP Singh, S Taub, DD Lillard, JW AF Sakthivel, Senthilkumar K. Singh, Udai P. Singh, Shailesh Taub, Dennis D. Lillard, James W. TI CXCL10 blockade protects mice from cyclophosphamide-induced cystitis SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Sakthivel, Senthilkumar K.] Emory Univ, Atlanta, GA 30322 USA. [Singh, Udai P.] Morehouse Sch Med, Atlanta, GA 30310 USA. [Singh, Shailesh; Lillard, James W.] Univ Louisville, Louisville, KY 40292 USA. [Taub, Dennis D.] NIA, Gerontol Res Ctr, Baltimore, MD 21224 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801139 ER PT J AU Santosa, S Hensrud, DD Votruba, SB Jensen, MD AF Santosa, Sylvia Hensrud, Donald D. Votruba, Susanne B. Jensen, Michael D. TI The Influence of Sex and Obesity Phenotype on Meal Fatty Acid Metabolism Before and After Weight Loss SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Santosa, Sylvia; Hensrud, Donald D.; Jensen, Michael D.] Mayo Clin, Endocrine Res Unit, Rochester, MN USA. [Votruba, Susanne B.] NIDDK, Obes & Diabet Clin Res Sect, NIH, Phoenix, AZ USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467803791 ER PT J AU Selvaraj, PK Mattson, MP Arumugam, TV AF Selvaraj, Pradeep Kumar Mattson, Mark P. Arumugam, Thiruma V. TI Role for Notch1 signaling in ischemic stroke-induced endothelial cell dysfunction SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Selvaraj, Pradeep Kumar; Arumugam, Thiruma V.] Texas Tech Univ, Dept Pharmaceut Sci, Hlth Sci Ctr, Amarillo, TX USA. [Mattson, Mark P.] NIA, Neurosci Lab, Intramural Res Program, Baltimore, MD 21224 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806403 ER PT J AU Sengupta, A Lichti, UF Carlson, BA Yuspa, SH Hatfield, DL AF Sengupta, Aniruddha Lichti, Ulrike F. Carlson, Bradley A. Yuspa, Stuart H. Hatfield, Dolph L. TI Targeted removal of the selenocysteine tRNA gene (trsp) in epidermis modulates skin function and development. SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Sengupta, Aniruddha; Carlson, Bradley A.; Hatfield, Dolph L.] NCI, LCP, Bethesda, MD 20892 USA. [Lichti, Ulrike F.; Yuspa, Stuart H.] NCI, LCBG, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802576 ER PT J AU Sengupta, A Lichti, UF Carlson, BA Yuspa, SH Hatfield, DL AF Sengupta, Aniruddha Lichti, Ulrike F. Carlson, Bradley A. Yuspa, Stuart H. Hatfield, Dolph L. TI Targeted removal SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Sengupta, Aniruddha; Carlson, Bradley A.; Hatfield, Dolph L.] NCI, CCR, LCP, Bethesda, MD 20892 USA. [Lichti, Ulrike F.; Yuspa, Stuart H.] NCI, LCBG, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801564 ER PT J AU Shafer-Weaver, KA Malyguine, A Hurwitz, AA AF Shafer-Weaver, Kimberly Ann Malyguine, Anatoli Hurwitz, Arthur A. TI Provision of tumor-specific CD4+T cells to enhance tumor immunity in a murine model of prostate cancer SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Shafer-Weaver, Kimberly Ann; Malyguine, Anatoli] NCI, SAIC Frederick Inc, Frederick, MD 21701 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801567 ER PT J AU Shea, MK Dallal, GE Dawson-Hughes, B Ordovas, JM O'Donnell, CJ Gundberg, CM Peterson, JW Booth, SL AF Shea, M. Kyla Dallal, Gerard E. Dawson-Hughes, Bess Ordovas, Jose M. O'Donnell, Christopher J. Gundberg, Caren M. Peterson, James W. Booth, Sarah L. TI Associations between vitamin K and circulating cytokines in older men and women SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Shea, M. Kyla; Peterson, James W.; Booth, Sarah L.] Tufts Univ HNRCA, Vitamin Lab K, Boston, MA USA. [Dawson-Hughes, Bess] Tufts Univ HNRCA, Calcium & Bone Lab, Boston, MA USA. [O'Donnell, Christopher J.] NHLBI, Framingham Heart Study, NIH, Framingham, MA USA. [Gundberg, Caren M.] Yale Univ, Sch Med, Dept Orthopaed, New Haven, CT USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467803147 ER PT J AU Shi, GP Cox, CA Vistica, BP Wawrousek, EF Gery, I AF Shi, Guangpu Cox, Catherine A. Vistica, Barbara P. Wawrousek, Eric F. Gery, Igal TI Phenotype switching by inflammation-inducing polarized Th17 cells, but not by Th1 cells SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Shi, Guangpu; Cox, Catherine A.; Vistica, Barbara P.; Wawrousek, Eric F.; Gery, Igal] NEI, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802290 ER PT J AU Shi, YB AF Shi, Yun-Bo TI Control of metamorphic timing by unliganded thyroid hormone receptor through the recruitment of histone deacetylase-containing corepressor complexes during frog development SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Shi, Yun-Bo] NIH, LGRD, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800106 ER PT J AU Shirey, JK Xiang, ZX Orton, D Brady, AE Johnson, KA Williams, R Ayala, JE Rodriguez, AL Wess, J Weaver, D Niswender, CM Conn, PJ AF Shirey, Jana K. Xiang, Zixiu Orton, Darren Brady, Ashley E. Johnson, Kari A. Williams, Richard Ayala, Jennifer E. Rodriguez, Alice L. Wess, Jurgen Weaver, David Niswender, Colleen M. Conn, P. Jeffrey TI An allosteric potentiator suggests a role for M4 muscarinic acetylcholine receptor (mAChR) in modulating excitatory hippocampal synaptic transmission SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Orton, Darren; Williams, Richard; Weaver, David] Vanderbilt Univ, Vanderbilt Inst Chem Biol, Nashville, TN USA. [Wess, Jurgen] NIDDK, NIH, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467807068 ER PT J AU Shriner, AK Sun, GZ Leonard, W Alugupalli, KR AF Shriner, Anne K. Sun, Guizhi Leonard, Warren Alugupalli, Kishore R. TI Distinct and Overlapping Functions for Thymic Stromal Lymphopoietin- and Interleukin 7-driven B cells in T cell-independent Antibody Responses SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Shriner, Anne K.; Sun, Guizhi; Alugupalli, Kishore R.] Thomas Jefferson Univ, Philadelphia, PA 19107 USA. [Leonard, Warren] NHLBI, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467803105 ER PT J AU Singh, A Zarember, KA Jain, AK Gallin, JI AF Singh, Anjali Zarember, Kol A. Jain, Ashish K. Gallin, John I. TI Impaired Priming and Activation of the NADPH Oxidase in Patients with TLR Signaling Defects SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Singh, Anjali; Zarember, Kol A.; Jain, Ashish K.; Gallin, John I.] NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800634 ER PT J AU Singh, S Zhang, HW Foley, J Hedrick, M Farber, J AF Singh, Satya Zhang, Hongwei Foley, John Hedrick, Michael Farber, Joshua TI Human T cells that are able to produce IL-17 express the chemokine receptor CCR6 SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Singh, Satya; Zhang, Hongwei; Foley, John; Hedrick, Michael; Farber, Joshua] NIAID, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801398 ER PT J AU Singh, V Feigenbaum, L Hurwitz, A AF Singh, Vinod Feigenbaum, Lionel Hurwitz, Arthur TI Tumor progression despite the presence of functional tumor-infiltrating CD8+T cells SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Singh, Vinod; Hurwitz, Arthur] NCI, LMI, Frederick, MD 21701 USA. [Feigenbaum, Lionel] SAIC Frederick, Transgen Mouse Model Lab, Frederick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467803031 ER PT J AU Snyder, MD Cassilly, D Samaroo, D Walk, A Sanborn, K AF Snyder, Michelle Dykstra Cassilly, Daniel Samaroo, Dave Walk, Alex Sanborn, Keri TI Dictyostelium discoideum amoeboid cells respond to microbial ligands SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Snyder, Michelle Dykstra; Cassilly, Daniel; Samaroo, Dave; Walk, Alex] Towson Univ, Towson, MD USA. [Snyder, Michelle Dykstra; Sanborn, Keri] NIAID, NIH, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467807516 ER PT J AU Sportes, C Hakim, FT Memon, SA Zhang, H Brown, MR Fleisher, TA Krumlauf, MC Babb, RR Chow, CK Fry, TJ Engels, J Buffet, R Morre, M Venzon, DJ Korngold, R Pecora, A Mackall, CL Gress, RE AF Sportes, Claude Hakim, Frances T. Memon, Sarfraz A. Zhang, Hua Brown, Margaret R. Fleisher, Thomas A. Krumlauf, Michael C. Babb, Rebecca R. Chow, Catherine K. Fry, Terry J. Engels, Julie Buffet, Renaud Morre, Michel Venzon, David J. Korngold, Robert Pecora, Andrew Mackall, Crystal L. Gress, Ronald E. TI Recombinant human IL-7 (rhIL-7) preferentially expands CD4+and CD8+naive T cells and enhances T cell receptor (TCR) repertoire diversity SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Sportes, Claude; Hakim, Frances T.; Memon, Sarfraz A.; Krumlauf, Michael C.; Babb, Rebecca R.; Gress, Ronald E.] NCI, ETIB, Bethesda, MD 20892 USA. [Zhang, Hua; Fry, Terry J.; Mackall, Crystal L.] NCI, POB, Bethesda, MD 20892 USA. [Brown, Margaret R.; Fleisher, Thomas A.; Chow, Catherine K.] NIH, Ctr Clin, Bethesda, MD 20892 USA. [Engels, Julie; Buffet, Renaud; Morre, Michel] Cytheris Inc, Issy Les Moulineaux, France. [Korngold, Robert; Pecora, Andrew] Hackensack Univ, Hackensack, NJ USA. RI Memon, Sarfraz/E-1198-2013 NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467808203 ER PT J AU States, JC Singh, AV Miller, HL Piao, YL Ko, MSH Knudsen, TB AF States, J. Christopher Singh, Amar V. Miller, Heather L. Piao, Yulan Ko, Minoru S. H. Knudsen, Thomas B. TI Prenatal arsenic exposure altered liver gene expression associated with accelerated atherosclerosis SO FASEB JOURNAL LA English DT Meeting Abstract C1 [States, J. Christopher; Singh, Amar V.; Miller, Heather L.; Knudsen, Thomas B.] Univ Louisville, Louisville, KY 40292 USA. [Piao, Yulan; Ko, Minoru S. H.] NIA, Baltimore, MD 21224 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806472 ER PT J AU Steele-Mortimer, O AF Steele-Mortimer, Olivia TI The Salmonella effector SopB affects phospholipid content of Salmonella-induced membrane ruffles SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Steele-Mortimer, Olivia] NIAID, Intracellular Parasites Lab, Rocky Mt Lab, Hamilton, MT USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467805255 ER PT J AU Storz, G Opdyke, JA Fozo, EM Waters, LS Kawano, M Zhang, AX AF Storz, Gisela Opdyke, Jason A. Fozo, Elizabeth M. Waters, Lauren S. Kawano, Mitsuoki Zhang, Aixia TI Varied functions of small, non-coding RNAs in bacteria SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Storz, Gisela; Opdyke, Jason A.; Fozo, Elizabeth M.; Waters, Lauren S.; Kawano, Mitsuoki; Zhang, Aixia] NICHD, Cell Biol & Metab Branch, NIH, Bethesda, MD USA. [Kawano, Mitsuoki] RIKEN Yokohama Inst, Genome Explorat Res Grp, Kanagawa, Japan. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802020 ER PT J AU Strbo, N Pahwa, S Kolber, M Fisher, E Franchini, G Podack, E AF Strbo, Natasa Pahwa, Savita Kolber, Michael Fisher, Eva Franchini, Genoveffa Podack, Eckhard TI HLA A2 restricted HIV specific mucosal and systemic immunity induced with secreted heat shock protein gp96-Ig SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Strbo, Natasa; Pahwa, Savita; Kolber, Michael; Fisher, Eva; Podack, Eckhard] Univ Miami, Miller Sch Med, Miami, FL 33136 USA. [Franchini, Genoveffa] NCI Bethesda, Vaccine Branch, NIH, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806263 ER PT J AU Sun, P Tropea, JE Austin, BP Cherry, S Waugh, DS AF Sun, Ping Tropea, Joseph E. Austin, Brian P. Cherry, Scott Waugh, David S. TI Structural characterization of the Yersinia pestis type III secretion system needle protein YscF in complex with its heterodimeric chaperone YscE/YscG SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Sun, Ping; Tropea, Joseph E.; Austin, Brian P.; Cherry, Scott; Waugh, David S.] NCI, Frederick, MD 21701 USA. NR 0 TC 0 Z9 0 U1 7 U2 10 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700237 ER PT J AU Talan, MI Ahmet, I Wan, RQ Mattson, MP Lakatta, EG AF Talan, Mark I. Ahmet, Ismayil Wan, Ruiqian Mattson, Mark P. Lakatta, Edward G. TI Intermittent fasting: fly in the oatmeal SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Talan, Mark I.; Ahmet, Ismayil; Lakatta, Edward G.] NIA, Cardiovasc Sci Lab, Baltimore, MD 21224 USA. [Wan, Ruiqian; Mattson, Mark P.] NIA, Neurosci Lab, Baltimore, MD 21224 USA. NR 0 TC 0 Z9 0 U1 0 U2 10 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700193 ER PT J AU Tauseef, M Kim, V Knezevic, N Vogel, S Malik, A Birnbaumer, L Mehta, D AF Tauseef, Mohammad Kim, Vidisha Knezevic, Nebojsa Vogel, Stephen Malik, Asrar Birnbaumer, Lutz Mehta, Dolly TI An indispensable role of TRPC6-mediated Ca2+entry in increasing lung microvascular permeability and acute lung injury SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Tauseef, Mohammad; Kim, Vidisha; Knezevic, Nebojsa; Vogel, Stephen; Malik, Asrar; Mehta, Dolly] Univ Illinois, Coll Med, Dept Pharmacol, Chicago, IL USA. [Birnbaumer, Lutz] NIH, Div Intramural Res, Bethesda, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467808002 ER PT J AU Tchapyjnikov, D Li, YD Pisitkun, T Knepper, MA AF Tchapyjnikov, Dmitry Li, Yuedan Pisitkun, Trairak Knepper, Mark A. TI Nuclear Proteomics of the Inner Medullary Collecting Duct (IMCD) SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Tchapyjnikov, Dmitry; Li, Yuedan; Pisitkun, Trairak; Knepper, Mark A.] NHLBI, Lab Kidney & Electrolyte Metab, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467807586 ER PT J AU Tewary, P Li, ZH de la Rosa, G Chen, Q Oppenheim, J Yang, D AF Tewary, Poonam Li, Zhenhua de la Rosa, Gonzalo Chen, Qian Oppenheim, Joost Yang, De TI Human Beta Defensin 3 (HBD3) induces migration and activation of antigen presenting cells and acts as an immune enhancer SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Tewary, Poonam; Li, Zhenhua; de la Rosa, Gonzalo; Chen, Qian; Oppenheim, Joost] NCI, Mol Immunoregulat Lab, Frederick, MD 21701 USA. [Yang, De] SAIC Frederick, Basic Res Program LMI, Frederick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801656 ER PT J AU Thomas, A Voltz, J Fubara, B Driehuys, B Zeldin, D AF Thomas, Abraham Voltz, James Fubara, Boma Driehuys, Bastiaan Zeldin, Darryl TI Hyperpolarized He-3 magnetic resonance imaging of ventilation after bacterial lipopolysaccharide exposure in mice SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Thomas, Abraham; Voltz, James; Zeldin, Darryl] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA. [Thomas, Abraham; Fubara, Boma; Driehuys, Bastiaan] Duke Univ, Med Ctr, Durham, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467807372 ER PT J AU Tiwari, N Wang, CC Brochetta, C Zabucchi, G Rivera, J Hong, WJ Blank, U AF Tiwari, Neeraj Wang, Cheng-Chun Brochetta, Cristiana Zabucchi, Giuliano Rivera, Juan Hong, Wanjin Blank, Ulrich TI Vesicular Associated Membrane Protein-8 is required for Mast Cell Degranulation but not Cytokine Secretion. SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Tiwari, Neeraj; Brochetta, Cristiana; Blank, Ulrich] INSERM, U699, Paris, France. [Tiwari, Neeraj; Brochetta, Cristiana; Blank, Ulrich] Univ Paris 07, Fac Med Site Bichat, Paris, France. [Wang, Cheng-Chun; Hong, Wanjin] IMCB, Singapore, Singapore. [Zabucchi, Giuliano] Univ Trieste, Trieste, Italy. [Rivera, Juan] NIAMSD, Lab Immune Cell Signaling, NIH, Bethesda, MD 20892 USA. RI Tiwari, Neeraj/F-7489-2014 OI Tiwari, Neeraj/0000-0003-3911-4809 NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700445 ER PT J AU Tiwari, S Mattson, MP Arumugam, TV AF Tiwari, Samata Mattson, Mark P. Arumugam, Thiruma V. TI Role of Toll-like receptors in ischemic stroke induced endothelial cell dysfunction SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Tiwari, Samata; Arumugam, Thiruma V.] Texas Tech Univ, Hlth Sci Ctr, Amarillo, TX USA. [Mattson, Mark P.] NIA, Neurosci Lab, Intramural Res Program, Baltimore, MD 21224 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467804313 ER PT J AU Tran, D Glass, D Shevach, E AF Tran, Dat Glass, Deborah Shevach, Ethan TI Human FOXP3+T regulatory cells suppress mouse T cell activation by targeting mouse dendritic cells via a human LFA-1/mouse ICAM-1 mediated interaction SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Tran, Dat; Glass, Deborah; Shevach, Ethan] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800365 ER PT J AU Trindade, CJ Heraue, JM Cecchinato, V Laurence, A Brenchley, J Tryniszewska, E Ferrari, MG Tsai, WP Vaccari, M Washington-Parks, R Douek, DC O'Shea, J Franchini, G AF Trindade, Christopher Julius Heraue, Jean-Michel Cecchinato, Valentina Laurence, Arian Brenchley, Jason Tryniszewska, Elzbieta Ferrari, Maria Grazia Tsai, Wen-Po Vaccari, Monica Washington-Parks, Robyn Douek, Daniel C. O'Shea, John Franchini, Genoveffa TI Preferential Loss Of Th17 T-cells At Mucosal Sites Predicts AIDS Progression In Simian Immunodeficiency Virus-Infected Macaques SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Trindade, Christopher Julius; Heraue, Jean-Michel; Cecchinato, Valentina; Tryniszewska, Elzbieta; Tsai, Wen-Po; Vaccari, Monica; Washington-Parks, Robyn; Franchini, Genoveffa] NCI, Anim Models Retroviral Vaccine Sect, Bethesda, MD 20892 USA. [Heraue, Jean-Michel] Inst Pasteur Madagascar, WHO Natl Influenza Lab, Antananarivo, Madagascar. [Laurence, Arian; O'Shea, John] Natl Inst Arthrit, Mol Immunol & Inflammat Branch, Bethesda, MD USA. [Brenchley, Jason; Douek, Daniel C.] NIAID, Vaccine Res Ctr, Bethesda, MD 20892 USA. [Tryniszewska, Elzbieta] Med Univ Bialystok, Dept Microbiol Diagnost, Bialystok, Poland. [Ferrari, Maria Grazia] Adv BioSci Labs, Kensington, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467803467 ER PT J AU Turanov, AA Kehr, S Carlson, BA Hatfield, DL Gladyshev, VN AF Turanov, Anton A. Kehr, Sebastian Carlson, Bradley A. Hatfield, Dolph L. Gladyshev, Vadim N. TI Mammalian thioredoxin reductases: roles in redox homeostasis and analysis of cellular targets SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Turanov, Anton A.; Kehr, Sebastian; Gladyshev, Vadim N.] Univ Nebraska, Dept Biochem, Lincoln, NE 68583 USA. [Carlson, Bradley A.; Hatfield, Dolph L.] NCI, Mol Biol Selenium Sect, NIH, Bethesda, MD 20892 USA. RI Gladyshev, Vadim/A-9894-2013 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467809168 ER PT J AU Uawithya, P Pisitkun, T Ruttenberg, BE Knepper, MA AF Uawithya, Panapat Pisitkun, Trairak Ruttenberg, Brian E. Knepper, Mark A. TI Transcriptional Profiling of Native Inner Medullary Collecting Duct Cells from Rat Kidney SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Uawithya, Panapat; Pisitkun, Trairak; Ruttenberg, Brian E.; Knepper, Mark A.] NHLBI, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467803047 ER PT J AU Ungvari, Z Mukhopadhyay, P Labinskyy, N Podlutsky, A Pacher, P Csiszar, A AF Ungvari, Zoltan Mukhopadhyay, Parta Labinskyy, Nazar Podlutsky, Andrej Pacher, Pal Csiszar, Anna TI Resveratrol attenuates mitochondrial ROS generation in endothelial cells treated with cigarette smoke extract SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Ungvari, Zoltan; Labinskyy, Nazar; Csiszar, Anna] New York Med Coll, Dept Physiol, Valhalla, NY 10595 USA. [Mukhopadhyay, Parta; Pacher, Pal] NIAAA, Lab Physiol Studies, NIH, Rockville, MD 20852 USA. [Podlutsky, Andrej] Sam & Ann Barshop Inst Longev & Aging Studies, San Antonio, TX USA. RI Podlutsky, Andrej/F-5421-2015 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801794 ER PT J AU Ungvari, Z Labinskyy, N Pacher, P Zhang, CH Podlutsky, A Csiszar, A AF Ungvari, Zoltan Labinskyy, Nazar Pacher, Pal Zhang, Cuihua Podlutsky, Andrej Csiszar, Anna TI Resveratrol attenuates cigarette smoking-induced pro-inflammatory alterations in the endothelial phenotype SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Ungvari, Zoltan; Labinskyy, Nazar; Csiszar, Anna] New York Med Coll, Dept Physiol, Valhalla, NY 10595 USA. [Pacher, Pal] NIAAA, Lab Physiol Studie, NIH, Rockville, MD 20852 USA. [Zhang, Cuihua] Texas A&M Univ, Dept Vet Physiol & Pharmacol, College Stn, TX 77843 USA. [Podlutsky, Andrej] Sam & Ann Barshop Inst Longev & Aging Studies, San Antonio, TX USA. RI Podlutsky, Andrej/F-5421-2015 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801762 ER PT J AU Uthus, EO Ross, SA AF Uthus, Eric O. Ross, Sharon A. TI Dietary selenium (Se) and copper (Cu) interact to affect homocysteine metabolism in rats SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Uthus, Eric O.] USDA ARS, GF Human Nutr Res Ctr, Grand Forks, ND USA. [Ross, Sharon A.] NCI, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801734 ER PT J AU Vandanmagsar, B Carter, A Lustig, A Collins, G Pyle, R Taub, D AF Vandanmagsar, Bolormaa Carter, Arne Lustig, Ana Collins, Gary Pyle, Robert Taub, Dennis TI Effects of T-cell derived Leptin on Thymic Function and Immune Regulation SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Vandanmagsar, Bolormaa] NIA, Immunol Lab, NIH, Baltimore, MD 21224 USA. [Carter, Arne; Lustig, Ana; Collins, Gary; Pyle, Robert; Taub, Dennis] NIA, LI, NIH, Baltimore, MD 21224 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700048 ER PT J AU Wang, NN Symons, JD Zhang, H Yang, GR Jia, ZJ Gonzalez, FJ Litwin, SE Soodvilai, S Yang, TX AF Wang, Ningning Symons, John D. Zhang, Hui Yang, Guangrui Jia, Zhanjun Gonzalez, Frank J. Litwin, Sheldon E. Soodvilai, Sunhapas Yang, Tianxin TI Distinct Functions of Vascular Endothelial and Smooth Muscle PPAR gamma in Regulation of Blood Pressure and Vascular Tone SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Symons, John D.] Univ Utah, Coll Hlth, Salt Lake City, UT USA. [Wang, Ningning; Yang, Tianxin] Vet Affairs Med Ctr, Salt Lake City, UT 84148 USA. [Gonzalez, Frank J.] NIH, Bethesda, MD 20892 USA. RI YANG, GUANGRUI/F-9693-2013 OI YANG, GUANGRUI/0000-0002-8310-8257 NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467809132 ER PT J AU Wang, PM Martin, WJ AF Wang, Ping Ming Martin, William J., II TI Bleomycin Clearance from the murine lung after a single intratracheal administration SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Wang, Ping Ming; Martin, William J., II] NIEHS, Lab Resp Biol, Res Triangle Pk, NC 27709 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801635 ER PT J AU Wansapura, AN Fedorova, OV Lasko, V Lingrel, JB Bagrov, AY Lorenz, JN AF Wansapura, Arshani N. Fedorova, Olga V. Lasko, Valerie Lingrel, Jerry B. Bagrov, Alexei Y. Lorenz, John N. TI Marinobufagenin enhances cardiac contractility in mice with ouabain-sensitive alpha 1 Na,K-ATPase (NKA) SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Wansapura, Arshani N.; Lasko, Valerie; Lingrel, Jerry B.; Lorenz, John N.] Univ Cincinnati, Cincinnati, OH USA. [Fedorova, Olga V.; Bagrov, Alexei Y.] NIA, Baltimore, MD 21224 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467804537 ER PT J AU Whittaker, P Clarke, JJ San, RHC Betz, JM Mazzola, EP Dunkel, VC AF Whittaker, Paul Clarke, Jane J. San, Richard H. C. Betz, Joseph M. Mazzola, Eugene P. Dunkel, Virginia C. TI Evaluating kava extracts and kavalactones for mutagenicity and toxicity SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Whittaker, Paul; Mazzola, Eugene P.; Dunkel, Virginia C.] US FDA, College Pk, MD USA. [Clarke, Jane J.; San, Richard H. C.] BioReliance, Rockville, MD USA. [Betz, Joseph M.] NIH, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801081 ER PT J AU Williams, JA Lumsden, J Yu, X Feigenbaum, L Zhang, JJ Steinberg, S Hodes, R AF Williams, Joy Ann Lumsden, Joanne Yu, Xiang Feigenbaum, Lionel Zhang, Jingjing Steinberg, Seth Hodes, Richard TI Regulation of thymic NKT cell development by the B7-CD28 costimulatory pathway SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Williams, Joy Ann; Zhang, Jingjing; Hodes, Richard] NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA. [Lumsden, Joanne] US Mil Malaria Vaccine Program, WRAIR NMRC, Silver Spring, MD USA. [Yu, Xiang] Superarrray Biosci Corp, Frederick, MD USA. [Feigenbaum, Lionel] NCI Frederick, NIH, Frederick, MD USA. [Steinberg, Seth] NCI, Biostat & Data Management Sect, NIH, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700509 ER PT J AU Wilson, MS Elnekave, E Mentink-Kane, M Pesce, J Ramalingam, T Thompson, R Flavell, R Cheever, A Wynn, T AF Wilson, Mark Stephen Elnekave, Eldad Mentink-Kane, Margaret Pesce, John Ramalingam, Thirumalai Thompson, Robert Flavell, Richard Cheever, Allen Wynn, Thomas TI IL-13R alpha 2 and IL-10 coordinately suppress Th2-dependent Inflammation and Immunopathology. SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Wilson, Mark Stephen; Elnekave, Eldad; Mentink-Kane, Margaret; Pesce, John; Ramalingam, Thirumalai; Thompson, Robert; Wynn, Thomas] NIAID, LPD, NIH, Bethesda, MD 20892 USA. [Flavell, Richard] Yale Univ, Sch Med, New Haven, CT USA. [Cheever, Allen] Biomed Res Ctr, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800593 ER PT J AU Wlodawer, A Li, M Melnikov, EE Rotanova, TV Maurizi, M Gustchina, A AF Wlodawer, Alexander Li, Mi Melnikov, Edward E. Rotanova, Tatyana V. Maurizi, Michael Gustchina, Alla TI Structural Features of Lon Proteases Deduced from Investigations of Isolated Domains of the Enzyme SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Wlodawer, Alexander; Li, Mi; Gustchina, Alla] NCI, Macromol Crystallog Lab, Frederick, MD 21701 USA. [Li, Mi] SAIC Frederick, Frederick, MD USA. [Melnikov, Edward E.; Rotanova, Tatyana V.] Shemyakin Ovchinnikov Inst, Moscow, Russia. [Maurizi, Michael] NCI, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800167 ER PT J AU Xia, D Esser, L Yu, CA AF Xia, Di Esser, Lothar Yu, Chang-An TI Inhibitor Complexed Structures of the Cytochrome bc1 from the Photosynthetic Bacterium Rhodobacter sphaeroides SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Xia, Di; Esser, Lothar] NCI, Cell Biol Lab, NIH, Bethesda, MD 20892 USA. [Yu, Chang-An] Oklahoma State Univ, Dept Biochem & Mol Biol, Still Water, OK USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467805571 ER PT J AU Xie, YL Hassan, SA Qazi, AM Tsai-Morris, CH Dufau, ML AF Xie, Yili Hassan, Sergio A. Qazi, Aamer M. Tsai-Morris, C. H. Dufau, Maria L. TI Intramolecular Disulfide Bridges of the Prolactin Receptor (PRLR) Short Form are Required for its Inhibitory Action on the Function of the Long form of the Receptor SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Xie, Yili; Qazi, Aamer M.; Tsai-Morris, C. H.; Dufau, Maria L.] NICHD, ERRB, PDEGEN, NIH, Bethesda, MD USA. [Hassan, Sergio A.] NIH, CMM DCB, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802231 ER PT J AU Xie, ZH Johnson, EJ Druey, KM AF Xie, Zhihui Johnson, Eric J. Druey, Kirk M. TI RGS13 suppresses CREB-dependent gene transcription SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Xie, Zhihui; Druey, Kirk M.] NIH, Bethesda, MD 20892 USA. [Johnson, Eric J.] Merck & Co Inc, N Wales, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800688 ER PT J AU Xu, XM Carlson, BA Zhang, Y Berry, MJ Gladyshev, VN Hatfield, DL AF Xu, Xue-Ming Carlson, Bradley A. Zhang, Yan Berry, Marla J. Gladyshev, Vadim N. Hatfield, Dolph L. TI Functional analysis of mammalian selenocysteine synthase SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Xu, Xue-Ming; Carlson, Bradley A.; Hatfield, Dolph L.] NCI, LCP, NIH, Bethesda, MD 20892 USA. [Zhang, Yan; Gladyshev, Vadim N.] Univ Nebraska, Lincoln, NE USA. [Berry, Marla J.] Univ Hawaii Manoa, Honolulu, HI 96822 USA. RI Gladyshev, Vadim/A-9894-2013 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467804714 ER PT J AU Yamada, S Anderson, SA Samtani, RR Lee, ES Lockett, EC Uwabe, C Shiota, K Lo, CW AF Yamada, Shigehito Anderson, Stasia A. Samtani, Rajeev R. Lee, Elaine S. Lockett, Elizaqbeth C. Uwabe, Chigako Shiota, Kohei Lo, Cecilia W. TI Digital Atlas of Human Embryonic Development by High Resolution Imaging SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Yamada, Shigehito; Samtani, Rajeev R.; Lee, Elaine S.; Lo, Cecilia W.] NHLBI, Lab Dev Biol, NIH, Bethesda, MD 20892 USA. [Anderson, Stasia A.] NHLBI, NHLBI Anim MRI Imaging Core, NIH, Bethesda, MD 20892 USA. [Yamada, Shigehito; Uwabe, Chigako; Shiota, Kohei] Kyoto Univ, Grad Sch Med, Congenital Anomaly Res Ctr, Kyoto, Japan. [Shiota, Kohei] Kyoto Univ, Grad Sch Med, Dept Anat & Dev Biol, Kyoto, Japan. [Lockett, Elizaqbeth C.] Natl Museum Hlth & Med, Human Dev Anat Ctr, Washington, DC USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801428 ER PT J AU Yang, D Chen, Q Su, SB Zhang, P Caspi, RR Micchalek, SM Rosenberg, HR Oppenheim, JJ AF Yang, De Chen, Qian Su, Shao-Bo Zhang, Ping Caspi, Rachel R. Micchalek, Suzanne M. Rosenberg, Helene R. Oppenheim, Joost J. TI Eosinophil-derived neurotoxin acts as an alarmin to activate TLR2-MyD88 signal pathway in dendritic cells and enhance Th2 immune responses SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Yang, De] NCI, Basic Res Program, SAIC Frederick, Frederick, MD 21701 USA. [Chen, Qian; Oppenheim, Joost J.] NCI, Lab Mol Immunoregulat, Frederick, MD 21701 USA. [Su, Shao-Bo; Caspi, Rachel R.] NEI, Immunol Lab, Bethesda, MD 20892 USA. [Zhang, Ping; Micchalek, Suzanne M.] UAB, Dept Microbiol, Birmingham, AL USA. [Rosenberg, Helene R.] NIAID, Lab Allerg Dis, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467803334 ER PT J AU Yang, JH Pospisil, R Ray, S Mage, R AF Yang, Jiahui Pospisil, Richard Ray, Satyajit Mage, Rose TI B-cell activating factor (BAFF) in a model of systemic lupus erythematosis: expression and rabbit homologue identification SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Yang, Jiahui; Pospisil, Richard; Ray, Satyajit; Mage, Rose] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800697 ER PT J AU Yang, W AF Yang, Wei TI Stop-action movie of UvrD helicase unwinding DNA SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Yang, Wei] NIH, Mol Biol Lab, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800572 ER PT J AU Yoo, MH Patterson, AD Xu, XM Carlson, BA Gladyshev, VN Hatfield, DL AF Yoo, Min-Hyuk Patterson, Andrew D. Xu, Xue-Ming Carlson, Bradley A. Gladyshev, Vadim N. Hatfield, Dolph L. TI Functional analysis of phospholipid hydroperoxide glutathione peroxidase by targeting its expression SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Yoo, Min-Hyuk; Xu, Xue-Ming; Carlson, Bradley A.; Hatfield, Dolph L.] NCI, CCR, Bethesda, MD 20892 USA. [Patterson, Andrew D.] NIH, Lab Metab, Bethesda, MD 20892 USA. [Gladyshev, Vadim N.] Univ Nebraska, Dept Biochem, Lincoln, NE 68583 USA. RI Gladyshev, Vadim/A-9894-2013; Patterson, Andrew/G-3852-2012 OI Patterson, Andrew/0000-0003-2073-0070 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467807378 ER PT J AU Yu, CI Gallego, M Marches, F Zurawski, S Ramilo, O Zurawski, G Garcia-Sastre, A Banchereau, J Palucka, AK AF Yu, Chun I. Gallego, Mike Marches, Florentina Zurawski, Sandra Ramilo, Octavio Zurawski, Gerard Garcia-Sastre, Adolfo Banchereau, Jacques Palucka, A. Karolina TI Cross-presentation of Influenza virus vaccine antigens to CD8+T cells in humanized mice SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Yu, Chun I.; Gallego, Mike; Marches, Florentina; Zurawski, Sandra; Zurawski, Gerard; Banchereau, Jacques; Palucka, A. Karolina] Baylor Inst Immunol Res, Baylor NIAID Cooperat Ctr Translat Res Human Immu, Dallas, TX USA. [Garcia-Sastre, Adolfo] Mt Sinai Sch Med, New York, NY USA. [Ramilo, Octavio] UT SW, Dallas, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801527 ER PT J AU Yu, MJ McCoy, JP Shen, RF Knepper, MA AF Yu, Ming-Jiun McCoy, J. Philip, Jr. Shen, Rong-Fong Knepper, Mark A. TI Production of an AQP2-Enriched Clonal mpkCCD Cell Line SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Yu, Ming-Jiun; Knepper, Mark A.] NHLBI, LKEM, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806810 ER PT J AU Yu, QG Shikuma, C Shiramizu, B Yewdell, JW Moss, B Hu, NJ AF Yu, Qigui Shikuma, Cecilia Shiramizu, Bruce Yewdell, Jonathan W. Moss, Bernaid Hu, Ningjie TI Effects of Antiretroviral Protease Inhibitors on Live Poxvirus-mediated Target Antigen Expression SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Yu, Qigui; Shikuma, Cecilia; Shiramizu, Bruce; Hu, Ningjie] Univ Hawaii Manoa, Dept Med, Honolulu, HI 96822 USA. [Yewdell, Jonathan W.; Moss, Bernaid] Natl Inst Allergies & Infect Dis, Viral Dis Lab, NIH, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467805335 ER PT J AU Yu, QG Shikuma, C Shiramizu, B Yewdell, J Moss, B Hu, NJ AF Yu, Qigui Shikuma, Cecilia Shiramizu, Bruce Yewdell, Jonathan Moss, Bernard Hu, Ningjie TI A Potentially Negative Impact of Antiretroviral Therapy on Efficacy of Live Poxvirus-based Vaccines SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Yu, Qigui; Shikuma, Cecilia; Shiramizu, Bruce; Hu, Ningjie] Univ Hawaii Manoa, Dept Med, Honolulu, HI 96822 USA. [Yewdell, Jonathan; Moss, Bernard] NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467803475 ER PT J AU Zamora, D Gordon-Larsen, P Jacobs, DR Loria, C Popkin, BM AF Zamora, Daisy Gordon-Larsen, Penny Jacobs, David R., Jr. Loria, Catherine Popkin, Barry M. TI Long-term adherence to the 2005 Dietary Guidelines for Americans is associated with lower risk of diabetes: 20-year findings from the Coronary Artery Risk Development in Young Adults (CARDIA) study SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Zamora, Daisy; Gordon-Larsen, Penny; Popkin, Barry M.] Univ N Carolina, Chapel Hill, NC USA. [Jacobs, David R., Jr.] Univ Minnesota, Minneapolis, MN USA. [Loria, Catherine] NHLBI, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806344 ER PT J AU Zeng, HW Uthus, EO Ross, SA Davis, CD AF Zeng, Huawei Uthus, Eric O. Ross, Sharon A. Davis, Cindy D. TI High dietary intake of sodium selenite does not affect gene mutation frequency in rat colon and liver SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Zeng, Huawei; Uthus, Eric O.] USDA ARS, Grand Forks Human Nutr Res Ctr, Grand Forks, ND 58202 USA. [Ross, Sharon A.; Davis, Cindy D.] NCI, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801709 ER PT J AU Zhang, Y Zhou, Y Schweizer, U Savaskan, NE Hua, D Kipnis, J Hatfield, DL Gladyshev, VN AF Zhang, Yan Zhou, You Schweizer, Ulrich Savaskan, Nicolai E. Hua, Deame Kipnis, Jonathan Hatfield, Dolph L. Gladyshev, Vadim N. TI Comparative analysis of selenocysteine machinery and selenoproteome gene expression in mouse brain identifies neurons as key functional sites of selenium in mammals SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Zhou, You] Univ Nebraska, Ctr Biotechnol, Lincoln, NE USA. [Schweizer, Ulrich] Charite, Neurosci Res Ctr, D-13353 Berlin, Germany. [Savaskan, Nicolai E.] ETH, Brain Res Inst, Zurich, Switzerland. [Savaskan, Nicolai E.] Univ Zurich, Zurich, Switzerland. [Kipnis, Jonathan] Univ Virginia, Charlottesville, VA USA. [Hatfield, Dolph L.] NCI, Mol Biol Selenium Sect, Lab Canc Prevent, Ctr Canc Res,NIH, Bethesda, MD 20892 USA. RI Gladyshev, Vadim/A-9894-2013; Schweizer, Ulrich/E-8105-2013 NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467804839 ER PT J AU Zhang, Y Liao, MJ Dufau, ML AF Zhang, Ying Liao, Mingjuan Dufau, Maria L. TI TRICHOSTATIN A INDUCED DEREPRESSION OF THE HUMAN LUTEINIZING HORMONE RECEPTOR GENE BY CELL-SPECIFIC PHOSPHATASE RELEASE FROM THE PROMOTER SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Zhang, Ying; Liao, Mingjuan; Dufau, Maria L.] NICHD, NIH, ERRB, PDEGEN, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801276 ER PT J AU Zhang, ZY Bagshaw, D Rovine, M Kris-Etherton, P Lanza, E Hartman, T AF Zhang, Zhiying Bagshaw, Deborah Rovine, Michael Kris-Etherton, Penny Lanza, Elaine Hartman, Terryl TI The Legume Inflammation Feeding Experiment (LIFE): Effects of Serum Lipid Levels SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Zhang, Zhiying; Bagshaw, Deborah; Kris-Etherton, Penny; Hartman, Terryl] Dept Nutr Sci, University Pk, PA USA. [Rovine, Michael] Dept Human Dev & Family Sci, University Pk, PA USA. [Lanza, Elaine] NCI, Bathesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467808169 ER PT J AU Zhao, HT Li, TW Yu, SQ Chock, B AF Zhao, Hongtao Li, Tianwei Yu, Shiqin Chock, Boon TI The effect of overexpressing mutant amyloid-(a)over-cap protein precursor and its A(a)over-cap fragments in SH-SY5Y cells SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Zhao, Hongtao; Li, Tianwei; Yu, Shiqin; Chock, Boon] NHLBI, Biochem Lab, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700718 ER PT J AU Zhou, XM Ferraris, JD Dmitrieva, N Liu, YS Burg, MB AF Zhou, Xiaoming Ferraris, Joan D. Dmitrieva, Natasha Liu, Yusen Burg, Maurice B. TI MKP-1 inhibits high NaCl-induced phosphorylation of p38, but does not inhibit high NaCl-induced activation of TonEBP: opposite roles of p38alpha and p38delta in activation of TonEBP. SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Zhou, Xiaoming] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Ferraris, Joan D.; Dmitrieva, Natasha; Burg, Maurice B.] NIH, LKEM, Bethesda, MD 20892 USA. [Liu, Yusen] Ohio State Univ, Columbus, OH 43210 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800692 ER PT J AU Zhuang, XL Northup, JK Ray, K AF Zhuang, Xiaolei Northup, John K. Ray, Kausik TI Human CaR trafficking is dependent on COPII transport pathway SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Zhuang, Xiaolei; Northup, John K.; Ray, Kausik] NIDCD, NIH, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700153 ER PT J AU Zhuravleva, M Sun, P AF Zhuravleva, Marina Sun, Peter TI Structural implications of Siglec-5 mediated sialo-glycan recognition SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Zhuravleva, Marina; Sun, Peter] NIAID, Struct Immunol Sect, NIH, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700195 ER PT J AU Dias, CAO Cano, VSP Rangel, SM Apponi, LH Frigieri, MC Muniz, JRC Garcia, W Park, MH Garratt, RC Zanelli, CF Valentini, SR AF Dias, Camila A. O. Cano, Veridiana S. P. Rangel, Suzana M. Apponi, Luciano H. Frigieri, Mariana C. Muniz, Joao R. C. Garcia, Wanius Park, Myung H. Garratt, Richard C. Zanelli, Cleslei F. Valentini, Sandro R. TI Structural modeling and mutational analysis of yeast eukaryotic translation initiation factor 5A reveal new critical residues and reinforce its involvement in protein synthesis SO FEBS JOURNAL LA English DT Article DE eIF5A; hypusine; mutational analysis; structural modeling; translation ID ELONGATION-FACTOR-P; SACCHAROMYCES-CEREVISIAE; HYPUSINE MODIFICATION; CRYSTAL-STRUCTURE; MESSENGER-RNA; FACTOR EIF-4D; AMINO-ACID; CELL-CYCLE; EIF5A; IDENTIFICATION AB Eukaryotic translation initiation factor 5A (eIF5A) is a protein that is highly conserved and essential for cell viability. This factor is the only protein known to contain the unique and essential amino acid residue hypusine. This work focused on the structural and functional characterization of Saccharomyces cerevisiae eIF5A. The tertiary structure of yeast eIF5A was modeled based on the structure of its Leishmania mexicana homologue and this model was used to predict the structural localization of new site-directed and randomly generated mutations. Most of the 40 new mutants exhibited phenotypes that resulted from eIF-5A protein-folding defects. Our data provided evidence that the C-terminal alpha-helix present in yeast eIF5A is an essential structural element, whereas the eIF5A N-terminal 10 amino acid extension not present in archaeal eIF5A homologs, is not. Moreover, the mutants containing substitutions at or in the vicinity of the hypusine modification site displayed nonviable or temperature-sensitive phenotypes and were defective in hypusine modification. Interestingly, two of the temperature-sensitive strains produced stable mutant eIF5A proteins - eIF5A(K56A) and eIF5A(Q22H,L93F)- and showed defects in protein synthesis at the restrictive temperature. Our data revealed important structural features of eIF5A that are required for its vital role in cell viability and underscored an essential function of eIF5A in the translation step of gene expression. C1 [Valentini, Sandro R.] Univ Estadual Paulista, Fac Ciencias Farmaceut, Dept Biol Sci, Sch Pharmaceut Sci, BR-14801902 Sao Paulo, Brazil. [Park, Myung H.] Natl Inst Dent & Craniofacial Res, Oral & Pharyngeal Canc Branch, NIH, Bethesda, MD USA. [Muniz, Joao R. C.; Garcia, Wanius; Garratt, Richard C.] Univ Sao Paulo, Inst Phys, Dept Phys & Informat, Ctr Struct Mol Biotechnol, BR-05508 Sao Paulo, Brazil. RP Valentini, SR (reprint author), Univ Estadual Paulista, Fac Ciencias Farmaceut, Dept Biol Sci, Sch Pharmaceut Sci, Rodovia Araraquara Jau,Km 1, BR-14801902 Sao Paulo, Brazil. EM valentsr@fcfar.unesp.br RI garratt, richard/F-6921-2011; Valentini, Sandro/C-4353-2012; Dias, Camila/G-3494-2012; zanelli, cleslei/C-1916-2013; Frigieri, Mariana/A-9801-2014; Silva, Wanius/L-3948-2016; Sao Carlos Institute of Physics, IFSC/USP/M-2664-2016 FU Intramural NIH HHS [Z01 DE000608-15, Z99 DE999999, Z01 DE000608-14] NR 45 TC 27 Z9 32 U1 0 U2 2 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1742-464X J9 FEBS J JI FEBS J. PD APR PY 2008 VL 275 IS 8 BP 1874 EP 1888 DI 10.1111/j.1742-4658.2008.06345.x PG 15 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 281LQ UT WOS:000254499500025 PM 18341589 ER PT J AU Browne, HN Sherry, R Stratton, P AF Browne, Hyacinth N. Sherry, Richard Stratton, Pamela TI Obturator hernia as a cause of recurrent pain in a patient with previously diagnosed endometriosis SO FERTILITY AND STERILITY LA English DT Editorial Material DE obturator hernia; chronic pelvic pain; endometriosis AB Recurrent chronic pelvic pain should prompt physicians to reassess the patient. The threshold to perform laparoscopy, and to consider and surgically treat all potential disease associated with pain, even non-gynecologic etiologies, should be low, especially in those whose pain is focal or unresponsive to hormone therapy. (Fertil Steril (R) 2008;89:962-3. (c) 2008 by American Society for Reproductive Medicine.) C1 [Browne, Hyacinth N.; Stratton, Pamela] NICHHD, Reprod Biol & Med Branch, NIH, Bethesda, MD 20892 USA. [Sherry, Richard] NCI, Surg Branch, NIH, Bethesda, MD 20892 USA. RP Browne, HN (reprint author), NICHHD, Reprod Biol & Med Branch, NIH, 10 Ctr Dr,Bldg 10,CRC 1E-3140, Bethesda, MD 20892 USA. EM brownehy@mail.nih.gov FU Intramural NIH HHS [ZIA HD008769-06] NR 3 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD APR PY 2008 VL 89 IS 4 BP 962 EP 963 DI 10.1016/j.fertnstert.2007.07.1381 PG 2 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 292EU UT WOS:000255250100029 PM 17880958 ER PT J AU Levens, ED Stegmann, BJ Feinberg, EC Larsen, FW AF Levens, Eric D. Stegmann, Barbara J. Feinberg, Eve C. Larsen, Frederick W. TI Ultrasonographic characteristics of the endometrium among patients with fibroids undergoing ART SO FERTILITY AND STERILITY LA English DT Editorial Material ID IN-VITRO FERTILIZATION; EMBRYO-TRANSFER; ASSISTED REPRODUCTION; UTERINE FIBROIDS; THICKNESS; IMPLANTATION; GONADOTROPIN; RECEPTIVITY; LEIOMYOMATA; MYOMECTOMY AB A retrospective cohort study examining all completed nondonor first ART cycles was performed to evaluate the ultrasonographic appearance of the endometrial pattern and thickness at time of hCG administration among precycle screened patients with uterine fibroids compared with patients without fibroids. There was no difference in the endometrial thickness (10.3 +/- 2.0 mm vs. 10.0 +/- 2.6 mm) between those with fibroids and controls; however, the rate of nonproliferative endometrial pattern (3.1% vs. 1.0%) and live birth rates (34.4% vs. 43.0%) were significantly different, most notably among those patients with intramural fibroids. (Fertil Steril (R) 2008; 89:1005-7. (c) 2008 by American Society for Reproductive Medicine.) C1 [Levens, Eric D.; Stegmann, Barbara J.; Feinberg, Eve C.] NICHHD, Reprod Biol & Med Branch, NIH, Bethesda, MD 20892 USA. [Levens, Eric D.; Stegmann, Barbara J.; Feinberg, Eve C.; Larsen, Frederick W.] Walter Reed Army Med Ctr, ART Program, Washington, DC 20307 USA. [Levens, Eric D.; Stegmann, Barbara J.; Feinberg, Eve C.; Larsen, Frederick W.] Walter Reed Army Med Ctr, Natl Naval Med Ctr, Washington, DC 20307 USA. [Levens, Eric D.; Stegmann, Barbara J.; Feinberg, Eve C.; Larsen, Frederick W.] Uniformed Serv Univ Hlth Sci, Washington, DC USA. RP Levens, ED (reprint author), NICHHD, Reprod Biol & Med Branch, NIH, Bldg 10,CRC,Room E1-3140,10 Ctr Dr, Bethesda, MD 20892 USA. EM levense@mail.nih.gov FU Intramural NIH HHS [Z99 HD999999] NR 20 TC 4 Z9 6 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD APR PY 2008 VL 89 IS 4 BP 1005 EP 1007 DI 10.1016/j.fertnstert.2007.03.096 PG 3 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 292EU UT WOS:000255250100039 PM 17662279 ER PT J AU Feinberg, E Larsen, F Wah, R Alvero, R Armstrong, A AF Feinberg, Eve Larsen, Frederick Wah, Robert Alvero, Ruben Armstrong, Alicia TI The utilization of assisted reproductive technology - Reply SO FERTILITY AND STERILITY LA English DT Letter ID INFERTILITY C1 [Feinberg, Eve; Armstrong, Alicia] NICHD, Reprod Biol & Med Branch, NIH, Bethesda, MD 20892 USA. [Feinberg, Eve; Larsen, Frederick; Wah, Robert; Armstrong, Alicia] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Feinberg, Eve; Larsen, Frederick; Wah, Robert; Armstrong, Alicia] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Alvero, Ruben] Univ Colorado, Hlth Sci Ctr, Aurora, CO USA. RP Feinberg, E (reprint author), NICHD, Reprod Biol & Med Branch, NIH, Bethesda, MD 20892 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD APR PY 2008 VL 89 IS 4 BP 1026 EP 1027 DI 10.1016/j.fertnstert.2008.02.107 PG 2 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 292EU UT WOS:000255250100048 ER PT J AU Wang, XD Kettenhofen, NJ Shiva, S Hogg, N Gladwin, MT AF Wang, Xunde Kettenhofen, Nicholas J. Shiva, Sruti Hogg, Neil Gladwin, Mark T. TI Copper dependence of the biotin switch assay: Modified assay for measuring cellular and blood nitrosated proteins SO FREE RADICAL BIOLOGY AND MEDICINE LA English DT Article DE nitric oxide; S-nitrosothiols; biotin switch assay; Hb-SNO; HSA-SNO; cyanine dye labeling; free radicals ID CYSTEINE-SULFINIC ACID; NITRIC-OXIDE; S-NITROSYLATION; ASCORBIC-ACID; NITROSOTHIOLS; HEMOGLOBIN; REDOX; MECHANISM; CHEMILUMINESCENCE; PEROXIREDOXINS AB Studies have shown that modification of critical cysteine residues in proteins leads to the regulation of protein function. These modifications include disulfide bond formation, glutathionylation, sulfenic and sulfinic acid formation, and S-nitrosation. The biotin switch assay was developed to specifically detect protein S-nitrosation (S. R. Jaffrey et al., Nat. Cell Biol. 3:193-197; 200 1). In this assay, proteins are denatured with SDS in the presence of methyl methane thiosulfonate (MMTS) to block free thiols. After acetone precipitation or Sephadex G25 separation to remove excess MMTS, HPDP-biotin and 1 mM ascorbate are added to reduce the S-nitrosothiol bonds and label the reduced thiols with biotin. The proteins are then separated by nonreducing SDS PAGE and detected using either streptavidin-HRP or anti-biotin-HRP conjugate. Our examination of this labeling scheme has revealed that the extent of labeling depends on the buffer composition and, importantly, on the choice of metal-ion chelator (DTPA vs EDTA). Unexpectedly, using purified S-nitrosated albumin, we have found that "contaminating" copper is required for the ascorbate-dependent degradation of S-nitrosothiol; this is consistent with the fact that ascorbate itself does not rapidly reduce S-nitrosothiols. Removal of copper from buffers by DTPA and other copper chelators preserves approximately 90% of the S-nitrosothiol, whereas the inclusion of copper and ascorbate completely eliminates the S-nitrosothiol in the preparation and increases the specific biotin labeling. These biotin switch experiments were confirmed using triiodide-based and copper-based reductive chemiluminescence. Additional modifications of the assay using N-ethylmaleimide for thiol blockade, ferricyanide pretreatment to stabilize S-nitrosated hemoglobin, and cyanine dye labeling instead of biotin are presented for the measurement of cellular and blood S-nitrosothiols. These results indicate that degradation of S-nitrosothiol in the standard biotin switch assay is metal-ion dependent and that experimental variability in S-nitrosothiol yields using this assay occurs secondary to the inclusion of metal-ion chelators in reagents and variable metal-ion contamination of buffers and labware. The addition of copper to ascorbate allows for a simple assay modification that dramatically increases sensitivity while maintaining specificity. (c) 2008 Elsevier Inc. All rights reserved. C1 [Gladwin, Mark T.] NHLBI, Pulm & Vasc Med Branch, Ctr Clin, NIH, Bethesda, MD 20892 USA. [Wang, Xunde; Gladwin, Mark T.] NIH, Ctr Clin, Dept Crit Care Med, Bethesda, MD 20892 USA. [Kettenhofen, Nicholas J.; Hogg, Neil] Med Coll Wisconsin, Dept Biophys, Milwaukee, WI 53226 USA. Med Coll Wisconsin, Free Rad Res Ctr, Milwaukee, WI 53226 USA. RP Gladwin, MT (reprint author), NHLBI, Pulm & Vasc Med Branch, Ctr Clin, NIH, Bldg 10, Bethesda, MD 20892 USA. EM mgladwin@nih.gov FU Intramural NIH HHS [Z01 CL008050-05]; NIGMS NIH HHS [GM55792, R01 GM055792, R29 GM055792] NR 47 TC 70 Z9 70 U1 3 U2 16 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0891-5849 J9 FREE RADICAL BIO MED JI Free Radic. Biol. Med. PD APR 1 PY 2008 VL 44 IS 7 BP 1362 EP 1372 DI 10.1016/j.freeradbiomed.2007.12.032 PG 11 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism SC Biochemistry & Molecular Biology; Endocrinology & Metabolism GA 287IK UT WOS:000254910600014 PM 18211831 ER PT J AU He, XJ Azarov, I Jeffers, A Presley, T Richardson, J King, SB Gladwin, MT Kim-Shapiro, DB AF He, Xiaojun Azarov, Ivan Jeffers, Anne Presley, Tennille Richardson, Jodi King, S. Bruce Gladwin, Mark T. Kim-Shapiro, Daniel B. TI The potential of Angeli's salt to decrease nitric oxide scavenging by plasma hemoglobin SO FREE RADICAL BIOLOGY AND MEDICINE LA English DT Review DE hemoglobin; nitric oxide; nitroxyl; Angeli's salt; red blood cell; hemolysis; free radicals ID SICKLE-CELL-DISEASE; CROSS-LINKED HEMOGLOBIN; RED-BLOOD-CELLS; ERYTHROCYTE CONSUMPTION; PULMONARY-HYPERTENSION; RELAXING FACTOR; SUPEROXIDE-DISMUTASE; BIOLOGICAL-ACTIVITY; VASCULAR-RESPONSE; HEME-PROTEINS AB Release of hemoglobin from the erythrocyte during intravascular hemolysis contributes to the pathology of a variety of diseased states. This effect is partially due to the enhanced ability of cell-free plasma hemoglobin, which is primarily found in the ferrous, oxygenated state, to scavenge nitric oxide. Oxidation of the cell-free hemoglobin to methemoglobin, which does not effectively scavenge nitric oxide, using inhaled nitric oxide has been shown to be effective in limiting pulmonary and systemic vasoconstriction. However, the ferric heme species may be reduced back to ferrous hemoglobin in plasma and has the potential to drive injurious redox chemistry. We propose that compounds that selectively convert cell-free hemoglobin to ferric, and ideally iron-nitrosylated heme species that do not actively scavenge nitric oxide, would effectively treat intravascular hemolysis. We show here that nitroxyl generated by Angeli's salt (sodium alpha-oxyhyponitrite, Na2N2O3) preferentially reacts with cell-free hemoglobin compared to that encapsulated in the red blood cell under physiologically relevant conditions. Nitroxyl oxidizes oxygenated ferrous hemoglobin to methemoglobin and can convert the methemoglobin to a more stable, less toxic species, iron-nitrosyl hemoglobin. These results support the notion that Angeli's salt or a similar compound could be used to effectively treat conditions associated with intravascular hemolysis. (c) 2007 Elsevier Inc. All rights reserved. C1 [Gladwin, Mark T.; Kim-Shapiro, Daniel B.] NHLBI, Vasc Med Branch, Ctr Clin, NIH, Bethesda, MD 20892 USA. [He, Xiaojun; Azarov, Ivan; Jeffers, Anne; Presley, Tennille; Richardson, Jodi] Wake Forest Univ, Dept Phys, Winston Salem, NC 27109 USA. [King, S. Bruce] Wake Forest Univ, Dept Chem, Winston Salem, NC 27109 USA. [Gladwin, Mark T.] NIH, Ctr Clin, Dept Crit Care Med, Bethesda, MD 20892 USA. RP Kim-Shapiro, DB (reprint author), NHLBI, Vasc Med Branch, Ctr Clin, NIH, Bldg 10, Bethesda, MD 20892 USA. EM shapiro@wfu.edu OI Azarov, Ivan/0000-0002-9886-3298 FU NHLBI NIH HHS [R37 HL058091-11, HL087891, R29 HL058091, K02 HL078706-04, R21 HL087891-01A1, HL62198, HL58091, K02 HL078706, R01 HL058091, R01 HL062198, R01 HL062198-07, R37 HL058091, R21 HL087891] NR 107 TC 11 Z9 14 U1 0 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0891-5849 J9 FREE RADICAL BIO MED JI Free Radic. Biol. Med. PD APR 1 PY 2008 VL 44 IS 7 BP 1420 EP 1432 DI 10.1016/j.freeradbiomed.2007.12.038 PG 13 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism SC Biochemistry & Molecular Biology; Endocrinology & Metabolism GA 287IK UT WOS:000254910600019 PM 18243145 ER PT J AU McCutchan, TF AF McCutchan, Thomas F. TI Is a monkey malaria from Borneo an emerging human disease? SO FUTURE MICROBIOLOGY LA English DT Editorial Material ID PLASMODIUM-KNOWLESI; TRANSMISSION C1 NIAID, NIH, Bethesda, MD 20892 USA. RP McCutchan, TF (reprint author), NIAID, NIH, Bethesda, MD 20892 USA. EM tmccutchan@niaid.nih.gov NR 8 TC 4 Z9 4 U1 0 U2 0 PU FUTURE MEDICINE LTD PI LONDON PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3 1QB, ENGLAND SN 1746-0913 J9 FUTURE MICROBIOL JI Future Microbiol. PD APR PY 2008 VL 3 IS 2 BP 115 EP 118 DI 10.2217/17460913.3.2.115 PG 4 WC Microbiology SC Microbiology GA 343EO UT WOS:000258835900002 PM 18366329 ER PT J AU Loomba, R Hwang, SJ O'Donnell, CJ Ellison, RC Vasan, RS D'Agostino, RB Liang, TJ Fox, CS AF Loomba, Rohit Hwang, Shih-Jen O'Donnell, Christopher J. Ellison, R. Curtis Vasan, Ramachandran S. D'Agostino, Ralph B., Sr. Liang, T. Jake Fox, Caroline S. TI Parental obesity and offspring serum alanine and aspartate aminotransferase levels: The Framingham heart study SO GASTROENTEROLOGY LA English DT Article ID FATTY LIVER-DISEASE; MIDDLE-AGED MEN; BODY-MASS INDEX; NONALCOHOLIC STEATOHEPATITIS; UNITED-STATES; INSULIN-RESISTANCE; CRYPTOGENIC CIRRHOSIS; METABOLIC SYNDROME; 7 COUNTRIES; PREVALENCE AB Background & Aims: Obesity is an important correlate of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. We sought to examine the relations between parental obesity and the serum ALT and AST levels among offspring in a community-based sample. Methods: Participants (n = 1732) of the Framingham Offspring Study (50% women; mean age, 42 years) who had serum ALT and AST measurements and both parents in the original Framingham cohort were studied. Study participants were grouped into early-onset parental obesity (n = 193) (at least one parent obese), later-onset parental obesity (n = 460), and no parental obesity (n = 1079) subgroups. The association between elevated ALT or AST levels and parental obesity was tested using generalized estimating equations to account for familial correlations. Results: In multivariable analysis including adjustment for offspring obesity, significantly higher ALT levels were observed among individuals with paternal early-onset obesity as compared with those without paternal obesity (P =.02). Offspring with early-onset paternal obesity were more likely to have elevated ALT levels compared with those without paternal obesity (odds ratio, 1.75; 95% confidence interval, 1.06-2.89; P =.03). There was no association with elevated ALT levels among offspring with maternal early-onset obesity (odds ratio, 1.10; 95% confidence interval, 0.76-1.59; P =.61). There was no association between parental obesity and serum AST levels. Conclusions: Earlyonset paternal obesity, but not maternal obesity, increases the odds of elevated serum ALT levels in offspring, suggesting a predisposition to developing elevated serum ALT levels that may be mediated through familial early-onset obesity. C1 [Loomba, Rohit; Liang, T. Jake] NIDDK, Liver Dis Branch, NIH, Bethesda, MD USA. [Hwang, Shih-Jen; O'Donnell, Christopher J.; Ellison, R. Curtis; Vasan, Ramachandran S.; D'Agostino, Ralph B., Sr.; Fox, Caroline S.] NHLBI, NIH, Framingham, MA USA. [O'Donnell, Christopher J.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Med,Cardiol Div, Boston, MA USA. [Ellison, R. Curtis] Boston Univ, Sch Med, Sect Prevent Med, Boston, MA 02118 USA. [Vasan, Ramachandran S.] Boston Univ, Sch Med, Cardiol Sect, Boston, MA 02118 USA. [Vasan, Ramachandran S.] Boston Univ, Sch Med, Dept Med, Prevent Med & Epidemiol Sect, Boston, MA 02118 USA. [D'Agostino, Ralph B., Sr.] Boston Univ, Dept Math, Boston, MA 02215 USA. [Fox, Caroline S.] Harvard Univ, Brigham & Womens Hosp, Dept Endocrinol Diabet & Hypertens, Boston, MA 02115 USA. RP Fox, CS (reprint author), 73 Mt Wayte Ave,Suite 2, Framingham, MA 01702 USA. EM foxca@nhlbl.nih.gov FU Intramural NIH HHS [Z99 HL999999]; NHLBI NIH HHS [K-24-HL-04334, K24 HL004334, N01-HC-25195, N01HC25195] NR 41 TC 26 Z9 27 U1 0 U2 2 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 2008 VL 134 IS 4 BP 953 EP 959 DI 10.1053/j.gastro.2008.0:L.037 PG 7 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 286NY UT WOS:000254853800015 PM 18395076 ER PT J AU Horiguchi, N Wang, L Mukhopadhyay, P Park, O Jeong, WI Lafdil, F Osei-Hyiaman, D Moh, A Fu, XY Pacher, P Kunos, G Gao, B AF Horiguchi, Norio Wang, Lei Mukhopadhyay, Partha Park, Ogyi Jeong, Won Il Lafdil, Fouad Osei-Hyiaman, Douglas Moh, Akira Fu, Xin Yuan Pacher, Pal Kunos, George Gao, Bin TI Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury SO GASTROENTEROLOGY LA English DT Article ID FATTY-ACID SYNTHESIS; HEPATIC STEATOSIS; BINDING PROTEIN; TNF-ALPHA; IN-VITRO; MICE; STAT3; DISEASE; INTERLEUKIN-6; ETHANOL AB Background & Aims: Signal transducer and activator of transcription 3 (STAT3) is known to be activated in human alcoholic liver disease, but its role in the pathogenesis of alcoholic liver injury remains obscure. Methods: The role of STAT3 in alcoholic liver injury was investigated in hepatocyte-specific STAT3 knockout (H-STAT3KO) mice and macrophage/neutrophil-specific STAT3 KO (M/N-STAT3KO) mice. Alcoholic liver injury was achieved by feeding mice a liquid diet containing 5% ethanol for up to 8 weeks. Results: Compared with wild-type mice, feeding H-STAT3KO mice with an ethanol-containing diet induced greater hepatic steatosis, hypertriglyceridemia, and hepatic expression of lipogenic genes (sterol regulatory element-binding protein, fatty acid synthase, acetylCoA carboxylase-1, and stearoyl-CoA desaturase 1), but less inflammation and lower expression of hepatic proinflammatory cytokines. In contrast, ethanol-fed M/N-STAT3KO mice showed more hepatic inflammation, worse injury, and increased hepatic expression of proinflammatory cytokines compared with wild-type mice. Kupffer cells isolated from ethanol-fed H-STAT3KO mice produced similar amounts of reactive oxygen species and tumor necrosis factor a, whereas Kupffer cells from M/N-STAT3KO mice produced more reactive oxygen species and tumor necrosis factor a compared with wild-type controls. Conclusions: These findings suggest that STAT3 regulates hepatic inflammation in a cell type-dependent manner during alcoholic liver injury: STAT3 in hepatocytes promotes whereas STAT3 in macrophages/Kupffer cells suppresses inflammation. In addition, activation of hepatocellular STAT3 ameliorates alcoholic fatty liver via inhibition of sterol regulatory element-binding protein 1c expression. C1 [Horiguchi, Norio; Wang, Lei; Park, Ogyi; Jeong, Won Il; Lafdil, Fouad; Gao, Bin] NIAAA, NIH, Lab Physiol Studies, Sect Liver Biol, Bethesda, MD 20892 USA. [Mukhopadhyay, Partha; Pacher, Pal] NIAAA, NIH, Lab Physiol Studies, Sect Oxidat Stress & Tissue Injury, Bethesda, MD 20892 USA. [Osei-Hyiaman, Douglas; Kunos, George] NIAAA, NIH, Lab Physiol Studies, Sect Neuroendocrinol, Bethesda, MD 20892 USA. [Moh, Akira; Fu, Xin Yuan] Indiana Univ, Sch Med, Dept Microbiol & Immunol, Indianapolis, IN 46202 USA. RP Gao, B (reprint author), NIAAA, NIH, Lab Physiol Studies, Sect Liver Biol, 5625 Fishers Lane,Room 2S-33, Bethesda, MD 20892 USA. EM bgao@mail.nih.gov RI MUKHOPADHYAY, PARTHA/G-3890-2010; Pacher, Pal/B-6378-2008; JEONG, WON IL/B-6615-2011 OI MUKHOPADHYAY, PARTHA/0000-0002-1178-1274; Pacher, Pal/0000-0001-7036-8108; FU Intramural NIH HHS [Z01 AA000368-06, Z01 AA000369-06, Z01 AA000375-02, Z99 AA999999] NR 51 TC 91 Z9 92 U1 0 U2 10 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 2008 VL 134 IS 4 BP 1148 EP 1158 DI 10.1053/j.gastro.2008.01.016 PG 11 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 286NY UT WOS:000254853800034 PM 18395093 ER PT J AU Flood, A Mai, V Pfeiffer, R Kahle, L Remaley, AT Lanza, E Schatzkin, A AF Flood, Andrew Mai, Volker Pfeiffer, Ruth Kahle, Lisa Remaley, Alan T. Lanza, Elaine Schatzkin, Arthur TI Insulin resistance and colorectal adenomas - Reply SO GASTROENTEROLOGY LA English DT Letter C1 [Flood, Andrew] Univ Minnesota, Div Epidemiol & Community Hlth, Minneapolis, MN 55455 USA. [Flood, Andrew] Univ Minnesota, Ctr Canc, Minneapolis, MN USA. [Mai, Volker] Univ Florida, Dept Microbiol & Cell Sci, Gainesville, FL 32611 USA. [Pfeiffer, Ruth; Schatzkin, Arthur] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. [Kahle, Lisa] Informat Management Serv Inc, Silver Spring, MD USA. [Remaley, Alan T.] NIH, Dept Lab Med, Ctr Clin, Bethesda, MD USA. [Lanza, Elaine] NCI, Ctr Canc Res, Bethesda, MD 20892 USA. RP Flood, A (reprint author), Univ Minnesota, Div Epidemiol & Community Hlth, Minneapolis, MN 55455 USA. RI Pfeiffer, Ruth /F-4748-2011 NR 2 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 2008 VL 134 IS 4 BP 1269 EP 1270 DI 10.1053/j.gastro.2008.02.004 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 286NY UT WOS:000254853800050 ER PT J AU Kazuki, Y Hoshiya, H Kai, Y Abe, S Takiguchi, M Osaki, M Kawazoe, S Katoh, M Kanatsu-Shinohara, M Inoue, K Kajitani, N Yoshino, T Shirayoshi, Y Ogura, A Shinohara, T Barrett, JC Oshimura, M AF Kazuki, Y. Hoshiya, H. Kai, Y. Abe, S. Takiguchi, M. Osaki, M. Kawazoe, S. Katoh, M. Kanatsu-Shinohara, M. Inoue, K. Kajitani, N. Yoshino, T. Shirayoshi, Y. Ogura, A. Shinohara, T. Barrett, J. C. Oshimura, M. TI Correction of a genetic defect in multipotent germline stem cells using a human artificial chromosome SO GENE THERAPY LA English DT Article DE human artificial chromosome; multipotent germline stem cell; microcell-mediated chromosome transfer ID EXPRESSION SYSTEM; MOUSE TESTIS; THERAPY; CLONING; VECTOR; CONSTRUCTION; GENOME; MICE AB Human artificial chromosomes (HACs) have several advantages as gene therapy vectors, including stable episomal maintenance that avoids insertional mutations and the ability to carry large gene inserts including regulatory elements. Multipotent germline stem (mGS) cells have a great potential for gene therapy because they can be generated from an individual's testes, and when reintroduced can contribute to the specialized function of any tissue. As a proof of concept, we herein report the functional restoration of a genetic deficiency in mouse p53(-/-) mGS cells, using a HAC with a genomic human p53 gene introduced via microcell-mediated chromosome transfer. The p53 phenotypes of gene regulation and radiation sensitivity were complemented by introducing the p53-HAC and the cells differentiated into several different tissue types in vivo and in vitro. Therefore, the combination of using mGS cells with HACs provides a new tool for gene and cell therapies. The next step is to demonstrate functional restoration using animal models for future gene therapy. C1 [Kazuki, Y.; Hoshiya, H.; Kai, Y.; Abe, S.; Takiguchi, M.; Osaki, M.; Kawazoe, S.; Kajitani, N.; Oshimura, M.] Tottori Univ, Dept Biomed Sci, Inst Regenerat Med & Biofunct, Grad Sch Med Sci, Yonago, Tottori 6838503, Japan. [Katoh, M.] Tottori Univ, Grad Sch Med Sci, Dept Human Genome Sci, Yonago, Tottori 6838503, Japan. [Kanatsu-Shinohara, M.; Shinohara, T.] Kyoto Univ, Grad Sch Med, Dept Mol Genet, Kyoto, Japan. [Inoue, K.] RIKEN, Bioresource Ctr, Ibaraki, Japan. [Yoshino, T.] Tottori Univ, Res Ctr Biosci & Technol, Div Funct Genom, Yonago, Tottori 6838503, Japan. [Shirayoshi, Y.] Tottori Univ, Grad Sch Med Sci, Dept Genet Med & Regenerat Therapeut, Inst Regenerat Med & Biofunct, Yonago, Tottori 6838503, Japan. [Barrett, J. C.] NCI, Lab Biosyst & Canc, Bethesda, MD 20892 USA. RP Oshimura, M (reprint author), Tottori Univ, Dept Biomed Sci, Inst Regenerat Med & Biofunct, Grad Sch Med Sci, 56 Nishicho,Nishimachi 86, Yonago, Tottori 6838503, Japan. EM oshimura@grape.med.tottori-u.ac.jp RI Ogura, Atsuo/J-3916-2014 OI Ogura, Atsuo/0000-0003-0447-1988 NR 32 TC 31 Z9 31 U1 1 U2 3 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0969-7128 J9 GENE THER JI Gene Ther. PD APR PY 2008 VL 15 IS 8 BP 617 EP 624 DI 10.1038/sj.gt.3303091 PG 8 WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine, Research & Experimental SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Genetics & Heredity; Research & Experimental Medicine GA 282IN UT WOS:000254561200007 PM 18305578 ER PT J AU Wu, H Romieu, I Sienra-Monge, JJ del Rio-Navarro, BE Burdett, L Yuenger, J Li, H Chanock, SJ London, SJ AF Wu, H. Romieu, I. Sienra-Monge, J-J del Rio-Navarro, B. E. Burdett, L. Yuenger, J. Li, H. Chanock, S. J. London, S. J. TI Lack of association between genetic variation in G-protein-coupled receptor for asthma susceptibility and childhood asthma and atopy SO GENES AND IMMUNITY LA English DT Article DE GPR154; allergy; asthma; genetic predisposition to disease; single nucleotide polymorphism ID GENOTYPE-PHENOTYPE ASSOCIATIONS; CASE-PARENT TRIADS; BRONCHIAL HYPERRESPONSIVENESS; LINKAGE DISEQUILIBRIUM; DISEASE GENES; POPULATION; HAPLOTYPES; POLYMORPHISMS; CHILDREN; DERMATITIS AB G-protein-coupled receptor for asthma susceptibility (GPRA or GPR154) was identified as an asthma and atopy candidate gene by positional cloning. Some subsequent studies suggest associations of GPRA single nucleotide polymorphisms ( SNPs) and haplotypes with asthma or atopy susceptibility. However, the associated SNPs or haplotypes vary among studies. The role of GPRA genetic variation in asthma and atopy remains unsolved. Published data on GRPA variants and asthma come exclusively from Caucasian and Asian populations. We examined whether GPRA SNPs and haplotypes are associated with asthma and atopy in a Mexican population. We genotyped and analyzed 27 GPRA SNPs in 589 nuclear families consisting of asthmatic children aged 4-17 years of age and their parents in Mexico City. Atopy was determined by skin prick tests to 25 aeroallergens. The 27 SNPs examined provided excellent coverage of the GPRA gene. GPRA SNPs and haplotypes were not associated with childhood asthma and the degree of atopy to aeroallergens in a Mexican population. Our review of studies of GPRA variants in relation to asthma phenotypes shows considerable heterogeneity. Accordingly, our results suggest that GPRA variants are not an important contributor to childhood asthma and atopy susceptibility in a Mexican population. C1 [London, S. J.] NIEHS, Epidemiol Branch,Div Intramural Res, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC 27709 USA. [Romieu, I.] Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico. [Sienra-Monge, J-J; del Rio-Navarro, B. E.] Hosp Infantil Mexico Fed Gomez, Mexico City, DF, Mexico. [Burdett, L.; Yuenger, J.; Chanock, S. J.] NCI, Adv Technol Ctr, Gaithersburg, MD USA. [Wu, H.; Li, H.; London, S. J.] NIEHS, Div Intramural Res, Lab Resp Biol, NIH, Res Triangle Pk, NC USA. RP London, SJ (reprint author), NIEHS, Epidemiol Branch,Div Intramural Res, NIH, Dept Hlth & Human Serv, 111 TW Alexander Dr,POB 12233,MD A3-05, Res Triangle Pk, NC 27709 USA. EM london2@niehs.nih.gov OI London, Stephanie/0000-0003-4911-5290 FU Intramural NIH HHS [Z01 ES025045-08, Z01 ES049019-12]; NIEHS NIH HHS [Z01 ES049019] NR 38 TC 11 Z9 13 U1 0 U2 3 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1466-4879 J9 GENES IMMUN JI Genes Immun. PD APR PY 2008 VL 9 IS 3 BP 224 EP 230 DI 10.1038/gene.2008.8 PG 7 WC Genetics & Heredity; Immunology SC Genetics & Heredity; Immunology GA 292LP UT WOS:000255267800005 PM 18340359 ER PT J AU Korman, BD Alba, MI Le, JM Alevizos, I Smith, JA Nikolov, NP Kastner, DL Remmers, EF Illei, GG AF Korman, B. D. Alba, M. I. Le, J. M. Alevizos, I. Smith, J. A. Nikolov, N. P. Kastner, D. L. Remmers, E. F. Illei, G. G. TI Variant form of STAT4 is associated with primary Sjogren's syndrome SO GENES AND IMMUNITY LA English DT Article DE primary Sjogren's syndrome; Sjogren's syndrome; STAT4; genetic polymorphism; association study ID SINGLE-NUCLEOTIDE POLYMORPHISM; RHEUMATOID-ARTHRITIS; GENE; PTPN22; IL23R; HAPLOTYPES; PSORIASIS; DISEASES; IL12B; RISK AB Single nucleotide polymorphisms in the STAT4 gene have recently been shown to be associated with rheumatoid arthritis ( RA) and systemic lupus erythematosus (SLE). Primary Sjogren's sydrome (pSS) is a related autoimmune disease thought to have a pathogenesis similar to these diseases. To test the hypothesis that the variant haplotype of STAT4 seen in RA and SLE is also associated with pSS, we genotyped rs7574865, the most strongly disease-associated SNP in the variant STAT4 haplotype, in 124 Caucasian pSS subjects and compared them to 1143 Caucasian controls. The disease-associated T allele was more common in chromosomes of the pSS patients (29.6%) than in controls (22.3%), leading to a P-value for association of 0.01. These results implicate polymorphisms in the STAT4 gene in the pathogenesis of pSS. C1 [Korman, B. D.; Le, J. M.; Kastner, D. L.; Remmers, E. F.] NIAMSD, Genet & Genom Branch, Complex Dis Genet Unit, Bethesda, MD 20892 USA. [Alba, M. I.; Alevizos, I.; Nikolov, N. P.; Illei, G. G.] Natl Inst Dent & Craniofacial Res, Mol Physiol & Therapeut Branch, Sjogrens Syndrome Clin, Bethesda, MD USA. [Smith, J. A.] NEI, Off Clin Director, Bethesda, MD 20892 USA. [Korman, B. D.] NIH, Clin Res Training Program, Bethesda, MD 20892 USA. RP Remmers, EF (reprint author), NIAMS, Genet & Genom Branch, 9 Mem Dr MSC-0908, Bethesda, MD 20892 USA. EM remmerse@mail.nih.gov FU Intramural NIH HHS; NCI NIH HHS [R01 CA121197]; NHGRI NIH HHS [N01-HG-65403] NR 19 TC 107 Z9 110 U1 0 U2 5 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1466-4879 J9 GENES IMMUN JI Genes Immun. PD APR PY 2008 VL 9 IS 3 BP 267 EP 270 DI 10.1038/gene.2008.1 PG 4 WC Genetics & Heredity; Immunology SC Genetics & Heredity; Immunology GA 292LP UT WOS:000255267800011 PM 18273036 ER PT J AU Bell, D Luna, MA Weber, RS Kaye, FJ El-Naggar, AK AF Bell, Diana Luna, Mario A. Weber, Randal S. Kaye, Frederic J. El-Naggar, Adel K. TI CRTCI/MAML2 fusion transcript in Warthin's tumor and Mucoepidermoid carcinoma: Evidence for a common genetic association SO GENES CHROMOSOMES & CANCER LA English DT Article ID MINOR SALIVARY-GLAND; PAROTID-GLAND; MECT1-MAML2; CYSTADENOLYMPHOMA; REARRANGEMENTS; ADENOLYMPHOMA; ABNORMALITY; DIAGNOSIS; CANCER; CHILD AB Translocations and gene fusions have an important early role in tumorigenesis. The t(11;19) translocation and its CRTCII MAML2 fusion transcript have been identified in several examples of both Warthin's tumor and mucoepidermoid carcinoma and are believed to be associated with the development of a subset of these tumors. To determine whether Warthin's tumor and mucoepidermoid carcinoma are genetically related, we used reverse transcriptase-polymerase chain reaction and DNA sequencing to analyze microdissected components of three tumors consisting of Warthin's tumor and mucoepidermoid carcinoma. We also investigated a metastatic melanoma to Warthin's tumor and a Warthin's carcinoma of the parotid gland for comparison. The fusion transcript was identified in both Warthin's tumor and matching mucoepidermoid carcinoma components of all three tumors, in the Warthin's carcinoma, and in the Warthin's tumor component but not in the metastatic melanoma. The results provide evidence for a link between the t(11; 19) fusion gene and the development of a subset of Warthin's tumors with concurrent mucoepidermoid carcinoma and possible malignant transformation to Warthin's carcinoma. C1 [Bell, Diana; Luna, Mario A.; El-Naggar, Adel K.] Univ Texas Houston, MD Anderson Canc Ctr, Dept Pathol, Unit 85, Houston, TX 77030 USA. [Weber, Randal S.; El-Naggar, Adel K.] Univ Texas Houston, MD Anderson Canc Ctr, Dept Head & Neck Surg, Houston, TX 77030 USA. [Kaye, Frederic J.] NCI, Bethesda, MD 20892 USA. [Kaye, Frederic J.] Naval Hosp, Bethesda, MD USA. RP El-Naggar, AK (reprint author), Univ Texas Houston, MD Anderson Canc Ctr, Dept Pathol, Unit 85, 1515 Holcombe Blvd, Houston, TX 77030 USA. EM anaggar@mdanderson.org RI kaye, frederic/E-2437-2011 FU NCI NIH HHS [CA-16672] NR 47 TC 32 Z9 32 U1 1 U2 3 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1045-2257 J9 GENE CHROMOSOME CANC JI Gene Chromosomes Cancer PD APR PY 2008 VL 47 IS 4 BP 309 EP 314 DI 10.1002/gcc.20534 PG 6 WC Oncology; Genetics & Heredity SC Oncology; Genetics & Heredity GA 267PA UT WOS:000253519900005 PM 18181164 ER PT J AU Li, QZ Yu, K AF Li, Qizhai Yu, Kai TI Improved correction for population stratification in genome-wide association studies by identifying hidden population structures SO GENETIC EPIDEMIOLOGY LA English DT Article DE population stratification; genome-wide association studies; likelihood ratio test; multidimensional scaling ID GENETIC ASSOCIATION; CANCER; INFERENCE; CLUSTERS; RISK; BIAS AB Hidden population substructure can cause population stratification and lead to false-positive findings in population-based genome-wide association (GWA) studies. Given a large panel of markers scanned in a GWA study, it becomes increasingly feasible to uncover the hidden population substructure within the study sample based on measured genotypes across the genome. Recognizing that population substructure can be displayed as clustered and/or continuous patterns of genetic variation, we propose a method that aims at the detection and correction of the confounding effect resulting from both patterns of population substructure. The proposed method is an extension of the EIGENSTRAT method (Price et al. [2006] Nat Genet 38:904-909). This approach is computationally feasible and easily applied to large-scale GWA studies. We show through simulation studies that, compared with the EIGENSTRAT method, the new method requires a smaller number of markers and yields a more appropriate correction for population stratification. C1 [Li, Qizhai; Yu, Kai] NCI, NIH, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. [Li, Qizhai] Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100864, Peoples R China. RP Yu, K (reprint author), NCI, NIH, Div Canc Epidemiol & Genet, 6120 Execut Blvd,EPS 8050, Rockville, MD 20852 USA. EM yuka@mail.nih.gov FU Intramural NIH HHS NR 29 TC 57 Z9 61 U1 1 U2 5 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0741-0395 J9 GENET EPIDEMIOL JI Genet. Epidemiol. PD APR PY 2008 VL 32 IS 3 BP 215 EP 226 DI 10.1002/gepi.20296 PG 12 WC Genetics & Heredity; Mathematical & Computational Biology SC Genetics & Heredity; Mathematical & Computational Biology GA 284EW UT WOS:000254690500003 PM 18161052 ER PT J AU Seyfert, AL Cristescu, MEA Frisse, L Schaack, S Thomas, WK Lynch, M AF Seyfert, Amanda L. Cristescu, Melania E. A. Frisse, Linda Schaack, Sarah Thomas, W. Kelley Lynch, Michael TI The rate and spectrum of microsatellite mutation in Caenorhabditis elegans and Daphnia pulex SO GENETICS LA English DT Article ID SIMPLE REPETITIVE DNA; MISMATCH REPAIR PROFICIENT; SACCHAROMYCES-CEREVISIAE; Y-CHROMOSOME; DROSOPHILA-MELANOGASTER; DINUCLEOTIDE REPEATS; GERMLINE MUTATIONS; POLYMERASE-ALPHA; POINT MUTATIONS; TANDEM REPEAT AB The effective use of microsatellite loci as tools for microevolutionary analysis requires knowledge of the factors influencing the rate and pattern of mutation, much of which is derived from indirect inference from population samples. Interspecific variation in microsatellite stability also provides a glimpse into aspects of phylogenetic constancy of mutational processes. Using long-term series of mutation-accumulation lines, we have obtained direct estimates of the spectrum of microsatellite mutations in two model systems: the nematode Caenorhabditis elegans and the microcrustacean Daphnia pulex. Although the scaling of the mutation rate with the number of tandem repeats is highly consistent across distantly related species, including yeast and human, the per-cell-division mutation rate appears to be elevated in multicellular species. Contrary to the expectations under the stepwise mutation model, most microsatellite mutations in C. elegans and D. pulex involve changes of multiple repeat units, with expansions being much more common than contractions. C1 [Seyfert, Amanda L.; Schaack, Sarah; Lynch, Michael] Indiana Univ, Dept Biol, Bloomington, IN 47405 USA. [Cristescu, Melania E. A.] Univ Windsor, Great Lakes Inst Environm Res, Windsor, ON N9B 3P4, Canada. [Frisse, Linda] US Natl Lib Med, Natl Ctr Biotechnol & Informat, Bethesda, MD 20894 USA. [Thomas, W. Kelley] Univ New Hampshire, Hubbard Ctr Genome Studies, Durham, NH 03824 USA. RP Seyfert, AL (reprint author), Indiana Univ, Dept Biol, 1001 E 3rd St, Bloomington, IN 47405 USA. EM aseyfert@indiana.edu FU Howard Hughes Medical Institute; NIGMS NIH HHS [R01 GM036827] NR 86 TC 45 Z9 48 U1 1 U2 16 PU GENETICS SOC AM PI BETHESDA PA 9650 ROCKVILLE AVE, BETHESDA, MD 20814 USA SN 0016-6731 J9 GENETICS JI Genetics PD APR PY 2008 VL 178 IS 4 BP 2113 EP 2121 DI 10.1534/genetics.107.081927 PG 9 WC Genetics & Heredity SC Genetics & Heredity GA 292AT UT WOS:000255239600022 PM 18430937 ER PT J AU Cheng, YZ Nash, HA AF Cheng, Yuzhong Nash, Howard A. TI Visual mutations reveal opposing effects of illumination on arousal in drosophila SO GENETICS LA English DT Article ID VOLATILE GENERAL-ANESTHETICS; TRP CHANNELS; MELANOGASTER; BEHAVIOR; PROTEIN; BRAIN; INAF AB The effect of illumination on alertness can be assessed by comparing the efficacy of an anesthetic under light vs. dark conditions. Results from such tests on wild-type flies and visual mutants demonstrate that, surprisingly, light has both positive and negative influences on arousal. These dual effects may explain aspects of the fly's daily activity and have potential clinical implications. C1 [Cheng, Yuzhong; Nash, Howard A.] NIH, Mol Biol Lab, Bethesda, MD 20892 USA. RP Nash, HA (reprint author), NIH, Mol Biol Lab, Bldg 35,Room 1B-1002,9000 Rockville Pike, Bethesda, MD 20892 USA. EM howardnash@mail.nih.gov FU Intramural NIH HHS NR 25 TC 5 Z9 5 U1 1 U2 1 PU GENETICS PI BALTIMORE PA 428 EAST PRESTON ST, BALTIMORE, MD 21202 USA SN 0016-6731 J9 GENETICS JI Genetics PD APR PY 2008 VL 178 IS 4 BP 2413 EP 2416 DI 10.1534/genetics.107.085324 PG 4 WC Genetics & Heredity SC Genetics & Heredity GA 292AT UT WOS:000255239600046 PM 18430958 ER PT J AU Mittal, P Hassan, SS Espinoza, J Kusanovic, JP Edwin, S Gotsch, F Erez, O Than, NG Mazaki-Tovi, S Romero, R AF Mittal, P. Hassan, S. S. Espinoza, J. Kusanovic, J. P. Edwin, S. Gotsch, F. Erez, O. Than, N. G. Mazaki-Tovi, S. Romero, R. TI The effect of gestational age and labor on placental growth hormone in amniotic fluid SO GROWTH HORMONE & IGF RESEARCH LA English DT Article DE placental growth hormone; amniotic fluid; gestational age; labor; pregnancy ID FETAL-GROWTH; INTRAUTERINE GROWTH; INSULIN-LIKE; TRANSGENIC MICE; VARIANT GENE; GH; PREGNANCIES; SERUM; LOCALIZATION; PROTEIN AB Objective: Placental growth hormone (PGH) is produced by trophoblast. This hormone becomes detectable in maternal serum during the first trimester of pregnancy. Its concentration increases as term approaches and becomes undetectable within one hour of delivery. PGH has important biological properties, including somatogenic (growth promotion), lactogenic, and lipolytic activity. Recently, PGH has been detected in amniotic fluid (AF) of midtrimester pregnancies. The purpose of this study was to determine whether PGH concentrations in AF change with advancing gestational age and in labor at term. Design: AF was assayed for PGH concentrations in samples obtained from patients undergoing genetic amniocentesis between 14 and 18 weeks of gestation (n = 67), normal patients at term not in labor (n = 24), and pregnant women at term in labor (n = 51). PGH concentrations were determined by ELISA. Non-parametric statistics were used for analysis. Results: (1) PGH was detected in all AF samples; (2) patients in the midtrimester had a higher median concentration of PGH in AF than those at term (midtrimester: median: 3140.5 pg/ml; range: 1124.2-13886.5 vs. term: median: 2021.1 pg/ml; range: 181.6-8640.8; p < 0.01); (3) there was no difference in the median concentration of PGH between women at term, not in labor, and those in labor (term not in labor: median: 2113.4 pg/ml; range: 449.3-8640.8 vs. term in labor: median: 2004.1 pg/ml; range: 181.6-8531.5; p = 0.73). Conclusions: (1) PGH is detectable in AF at both mid- and third trimesters; (2) the median AF concentration of PGH is significantly lower at term when compared to the second trimester; (3) labor at term is not associated with changes in the AF concentration of PGH. The role of this unique placental hormone now found in the fetal compartment requires further investigation. (C) 2007 Elsevier Ltd. All rights reserved. C1 [Mittal, P.; Hassan, S. S.; Espinoza, J.; Kusanovic, J. P.; Edwin, S.; Gotsch, F.; Erez, O.; Than, N. G.; Mazaki-Tovi, S.; Romero, R.] NICHD, Perinat Res Branch, NIH, DHHS, Bethesda, MD 20892 USA. [Mittal, P.; Hassan, S. S.; Espinoza, J.; Mazaki-Tovi, S.] Wayne State Univ, Sch Med, Dept Obstet & Gynecol, Detroit, MI 48201 USA. [Romero, R.] Wayne State Univ, Ctr Mol Med & Genet, Detroit, MI 48201 USA. [Mittal, P.; Hassan, S. S.; Espinoza, J.; Kusanovic, J. P.; Edwin, S.; Gotsch, F.; Erez, O.; Than, N. G.; Mazaki-Tovi, S.; Romero, R.] NICHD, Perinat Res Branch, NIH, DHHS, Detroit, MI 48201 USA. RP Mittal, P (reprint author), NICHD, Perinat Res Branch, NIH, DHHS, Bethesda, MD 20892 USA. EM nichdprbchiefstaff@mail.nih.gov FU Intramural NIH HHS [Z01 HD002401-15, Z01 HD002400-16] NR 35 TC 9 Z9 9 U1 0 U2 0 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1096-6374 J9 GROWTH HORM IGF RES JI Growth Horm. IGF Res. PD APR PY 2008 VL 18 IS 2 BP 174 EP 179 DI 10.1016/j.ghir.2007.08.003 PG 6 WC Cell Biology; Endocrinology & Metabolism SC Cell Biology; Endocrinology & Metabolism GA 278PN UT WOS:000254298900008 PM 17910928 ER PT J AU Young, NS Kaufman, DW AF Young, Neal S. Kaufman, David W. TI The epidemiology of acquired aplastic anemia SO HAEMATOLOGICA-THE HEMATOLOGY JOURNAL LA English DT Editorial Material ID BONE-MARROW-TRANSPLANTATION; POPULATION; CYCLOSPORINE; ETIOLOGY; RISK C1 [Young, Neal S.] NHLBI, Hematol Branch, Bethesda, MD 20892 USA. Boston Univ, Slone Epidemiol Ctr, Boston, MA 02215 USA. RP Young, NS (reprint author), NHLBI, Hematol Branch, Bethesda, MD 20892 USA. NR 25 TC 40 Z9 41 U1 3 U2 4 PU FERRATA STORTI FOUNDATION PI PAVIA PA VIA GIUSEPPE BELLI 4, 27100 PAVIA, ITALY SN 0390-6078 J9 HAEMATOL-HEMATOL J JI Haematol-Hematol. J. PD APR PY 2008 VL 93 IS 4 BP 489 EP 492 DI 10.3324/haematol.12855 PG 4 WC Hematology SC Hematology GA 284KL UT WOS:000254705200003 PM 18379007 ER PT J AU Rosenberg, PS Alter, BP Ebell, W AF Rosenberg, Philip S. Alter, Blanche P. Ebell, Wolfram TI Cancer risks in Fanconi anemia: findings from the German Fanconi Anemia Registry SO HAEMATOLOGICA-THE HEMATOLOGY JOURNAL LA English DT Article DE acute myeloid leukemia; neoplasms; bone marrow failure; Fanconi anemia; bone marrow transplantation; epidemiology ID BONE-MARROW-TRANSPLANTATION; PATHWAY AB Background Fanconi anemia is an inherited genomic instability syndrome associated with progressive bone marrow failure leading to death or the requirement for hematopoietic stem cell transplantation, acute myeloid leukemia, and solid tumors. Prior epidemiological studies have quantified the risks of bone marrow failure, acute myeloid leukemia and solid tumors, but these estimates have not been replicated. Design and Methods We assembled a cohort of 181 patients with Fanconi anemia mostly from Germany. We calculated the ratio of observed to expected cancers, and the risks of bone marrow failure, acute myeloid leukemia, and solid tumors by age. Results The first adverse event was bone marrow failure in 66 patients, acute meyloid leukemia in 14 patients and solid tumors in 10 patients. The ratio of observed to expected cancers was 44 for all cancers, 26 for all solid tumors, and 868 for acute myeloid leukemia; these increased risks were statistically significant. Significantly elevated ratios of observed to expected cancers were observed for esophageal (6281), vulvar (2411), head and neck (240), breast (34) and brain (23) tumors. Absent or abnormal radii, and a five-item congenital abnormality score, were Significant risk factors for bone marrow failure. The cumulative incidence of bone marrow failure by the age of 10 years varied from 12.6% in the lowest bone marrow failure risk group to 84% in the highest. The relative hazard of bone marrow failure was significantly higher in complementation group G versus A (relative hazard=2.2) and in C versus A (relative hazard=5.4). Conclusions Findings from the German Fanconi Anemia Registry cohort validate prior risk estimates, and strongly support the concept that Fanconi anemia is a highly penetrant cancer susceptibility syndrome with early onset of acute myeloid leukemia and slightly later onset of specific solid tumors. C1 [Rosenberg, Philip S.] NCI, Biostat Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Rockville, MD 20852 USA. [Alter, Blanche P.] NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Rockville, MD 20852 USA. [Ebell, Wolfram] Charite Univ Med Berlin, Dept Pediat, Berlin, Germany. RP Rosenberg, PS (reprint author), NCI, Biostat Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, 6120 Execut Blvd,Execut Plaza S,Room 8022, Rockville, MD 20852 USA. EM rosenbep@mail.nih.gov FU Intramural NIH HHS NR 20 TC 81 Z9 82 U1 0 U2 3 PU FERRATA STORTI FOUNDATION PI PAVIA PA VIA GIUSEPPE BELLI 4, 27100 PAVIA, ITALY SN 0390-6078 J9 HAEMATOL-HEMATOL J JI Haematol-Hematol. J. PD APR PY 2008 VL 93 IS 4 BP 511 EP 517 DI 10.3324/haematol.12234 PG 7 WC Hematology SC Hematology GA 284KL UT WOS:000254705200007 PM 18322251 ER PT J AU Backinger, CL Michaels, CN Jefferson, AM Fagan, P Hurd, AL Grana, R AF Backinger, Cathy L. Michaels, Carol N. Jefferson, Anne Marie Fagan, Pebbles Hurd, Ami L. Grana, Rachel TI Factors associated with recruitment and retention of youth into smoking cessation intervention studies - a review of the literature SO HEALTH EDUCATION RESEARCH LA English DT Review ID SUBSTANCE-ABUSING ADOLESCENTS; RANDOMIZED CONTROLLED-TRIAL; NICOTINE PATCH THERAPY; TOBACCO CESSATION; FUTURE-DIRECTIONS; FOLLOW-UP; SMOKERS; PROGRAM; PREVENTION; EFFICACY AB This paper examines factors associated with high levels of recruitment and retention of youth into smoking cessation interventions. Fifty-five articles published from 1976 to June 2004 reported cessation outcomes were analyzed to examine the associations between selected variables and recruitment and retention rates. Studies with participants who smoked <= 5 cigarettes per day (cpd) were more likely to have recruitment rates >= 85%. Yet, studies with participants who smoked >= 6 cpd were more likely to have high retention rates. Studies that did not use incentives were more likely to have retention rates at end of intervention >= 85%. Findings indicate a lack of information reported about recruitment and retention procedures in adolescent tobacco cessation studies. Additional analyses and research need to be conducted to identify successful methods. C1 [Backinger, Cathy L.; Fagan, Pebbles] NCI, Div Canc Control & Populat Sci, Behav Res Program, Tobacco Control Branch, Bethesda, MD 20892 USA. RP Backinger, CL (reprint author), NCI, Div Canc Control & Populat Sci, Behav Res Program, Tobacco Control Branch, Bethesda, MD 20892 USA. EM backingc@mail.nih.gov NR 68 TC 14 Z9 14 U1 1 U2 8 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0268-1153 J9 HEALTH EDUC RES JI Health Educ. Res. PD APR PY 2008 VL 23 IS 2 BP 359 EP 368 DI 10.1093/her/cym053 PG 10 WC Education & Educational Research; Public, Environmental & Occupational Health SC Education & Educational Research; Public, Environmental & Occupational Health GA 278NR UT WOS:000254294100016 PM 17884834 ER PT J AU Travis, LB Yahalom, J AF Travis, Lois B. Yahalom, Joachim TI Cancer survivorship - Preface SO HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA LA English DT Editorial Material C1 [Travis, Lois B.] NCI, NIH, Div Canc Epidemiol & Genet, Dept Hlth & Human Derv, Bethesda, MD 20892 USA. [Yahalom, Joachim] Mem Sloan Kettering Canc Ctr, Dept Radiat Oncol, New York, NY 10021 USA. RP Travis, LB (reprint author), NCI, NIH, Div Canc Epidemiol & Genet, Dept Hlth & Human Derv, Bethesda, MD 20892 USA. EM travls1122@optoiiline.net; yahalomj@mskcc.org NR 0 TC 3 Z9 3 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0889-8588 J9 HEMATOL ONCOL CLIN N JI Hematol. Oncol. Clin. North Am. PD APR PY 2008 VL 22 IS 2 BP XI EP XII DI 10.1016/j.hoc.2008.02.001 PG 2 WC Oncology; Hematology SC Oncology; Hematology GA 293GS UT WOS:000255324200001 PM 18395143 ER PT J AU Rowland, JH Bellizzi, KM AF Rowland, Julia H. Bellizzi, Keith M. TI Cancer survivors and survivorship research: A reflection on today"s successes and tomorrows challenges SO HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; BREAST-CANCER; SOCIAL SUPPORT; LONG-TERM; TEACHABLE MOMENT; HEALTH BEHAVIORS; UNITED-STATES; PATIENT; AGE; INTERVENTION AB As advances in cancer medicine turn this once uniformly fatal illness into a curable disease for growing numbers and a chronic illness for many, understanding and meeting the needs of long-term cancer survivors and their caregivers has become a major public health challenge, a challenge made more urgent by the aging of the population. This article reviews the profile of today's cancer survivors along with the demographic information on what this profile might look like in the future. Current directions in and the knowledge gained from the growing body of cancer survivorship research and the science of the long-term and late consequences to individuals, families, and society of people living longer with a cancer history are delineated. C1 [Rowland, Julia H.; Bellizzi, Keith M.] NCI, NIH, Div Canc Control & Populat Sci, Dept Hlth & Human Serv,Off Canc Survivorship, Bethesda, MD 20892 USA. RP Rowland, JH (reprint author), NCI, NIH, Div Canc Control & Populat Sci, Dept Hlth & Human Serv,Off Canc Survivorship, 6116 Execut Blvd,Suite 404,MSC 8336, Bethesda, MD 20892 USA. EM rowlancli@mail.nih.gov NR 80 TC 39 Z9 40 U1 2 U2 6 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0889-8588 J9 HEMATOL ONCOL CLIN N JI Hematol. Oncol. Clin. North Am. PD APR PY 2008 VL 22 IS 2 BP 181 EP + DI 10.1016/j.hoc.2008.01.008 PG 21 WC Oncology; Hematology SC Oncology; Hematology GA 293GS UT WOS:000255324200002 PM 18395144 ER PT J AU Ng, AK Travis, LB AF Ng, Andrea K. Travis, Lois B. TI Second primary cancers: An overview SO HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA LA English DT Review ID NON-HODGKINS-LYMPHOMA; SURGICAL ADJUVANT BREAST; LONG-TERM SURVIVORS; MALIGNANCIES FOLLOWING TREATMENT; MULTIPLE PRIMARY TUMORS; ACUTE MYELOID-LEUKEMIA; SOFT-TISSUE SARCOMA; RADIATION-THERAPY; CONTRALATERAL BREAST; TESTICULAR-CANCER AB Substantial improvements in die past few decades in cancer detection and supportive care along with advances in therapy have led to growing numbers of cancer survivors. In view of the prolongation of survival in increasing numbers of patients, identification and quantification of the late effects of cancer and its therapy have become critical. One of die most serious events experienced by cancer survivors is the diagnosis of a new cancer. The number of patients who have second or higher-order cancers is increasing, and solid tumors are a leading cause of mortality among several populations of long-term survivors, including patients who have Hodgkin lymphoma. The focus of this article is treatment-associated malignancies in survivors of selected adult cancers. C1 [Ng, Andrea K.] Brigham & Womens Hosp, Dana Faber Canc Inst, Dept Radiat Oncol, Boston, MA 02115 USA. [Travis, Lois B.] NCI, NIH, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, Bethesda, MD 20892 USA. RP Ng, AK (reprint author), Brigham & Womens Hosp, Dana Faber Canc Inst, Dept Radiat Oncol, 75 Francis St, Boston, MA 02115 USA. EM ang@lroc.harvord.edu NR 119 TC 32 Z9 33 U1 3 U2 5 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0889-8588 J9 HEMATOL ONCOL CLIN N JI Hematol. Oncol. Clin. North Am. PD APR PY 2008 VL 22 IS 2 BP 271 EP + DI 10.1016/j.hoc.2008.01.007 PG 20 WC Oncology; Hematology SC Oncology; Hematology GA 293GS UT WOS:000255324200008 PM 18395150 ER PT J AU Travis, LB Yahalom, J AF Travis, Lois B. Yahalom, Joachim TI Cancer survivorship: Facing forward SO HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA LA English DT Article ID BREAST-CANCER; BIG SCIENCE; SUSCEPTIBILITY; CHEMOTHERAPY; CARE AB In the last three decades, die number of cancer survivors in the United States has tripled and is growing by 2% each year. In 2004, there were an estimated 10.7 million cancer survivors (representing 3.5% of the United States population) with a concomitant effect on public health. The growing and heterogeneous population of cancer survivors provides important opportunities for clinical and epidemiologic research into cancer biology, long-term treatment effects, prevention, and interventional research. In this article, the authors briefly review the history of the efforts that served to coalesce efforts to champion survivorship research, identify future challenges, and provide a perspective on future recommendations. C1 [Travis, Lois B.] NCI, NIH, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, Bethesda, MD USA. [Yahalom, Joachim] Mem Sloan Kettering Canc Ctr, Dept Radiat Oncol, New York, NY 10021 USA. RP Travis, LB (reprint author), 1275 E 1st Ave, New York, NY 10065 USA. EM travis1122@optonline.net NR 25 TC 1 Z9 1 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0889-8588 J9 HEMATOL ONCOL CLIN N JI Hematol. Oncol. Clin. North Am. PD APR PY 2008 VL 22 IS 2 BP 365 EP + DI 10.1016/j.hoc.2008.01.009 PG 8 WC Oncology; Hematology SC Oncology; Hematology GA 293GS UT WOS:000255324200014 PM 18395156 ER PT J AU Lai, JP Sandhu, DS Yu, CR Han, T Moser, CD Jackson, KK Guerrero, RB Aderca, I Isomoto, H Garrity-Park, MM Zou, HZ Shire, AM Nagorney, DM Sanderson, SO Adjei, AA Lee, JS Thorgeirsson, SS Roberts, LR AF Lai, Jin-Ping Sandhu, Dalbir S. Yu, Chunrong Han, Tao Moser, Catherine D. Jackson, Kenard K. Guerrero, Ruben Bonilla Aderca, Ileana Isomoto, Hajime Garrity-Park, Megan M. Zou, Hongzhi Shire, Abdirashid M. Nagorney, David M. Sanderson, Schuyler O. Adjei, Alex A. Lee, Ju-Seog Thorgeirsson, Snorri S. Roberts, Lewis R. TI Sulfatase 2 up-regulates glypican 3, promotes fibroblast growth factor signaling, and decreases survival in hepatocellular carcinoma SO HEPATOLOGY LA English DT Article ID MITOGENIC ACTIVITY; PANCREATIC-CANCER; BREAST-CANCER; TUMOR-GROWTH; IN-VIVO; HSULF-1; CELLS; OLIGOSACCHARIDES; INHIBITORS; INVASION AB It has been shown that the heparin-degrading endosulfatase, sulfatase 1 (SULF1), functions as a liver tumor suppressor, but the role of the related sulfatase, sulfatase 2 (SULF2), in liver carcinogenesis remains to be elucidated. We investigated the effect of SULF2 on liver tumorigenesis. Expression of SULF2 was increased in 79 (57%) of 139 hepatocellular carcinomas (HCCs) and 8 (73%) of 11 HCC cell lines. Forced expression of SULF2 increased HCC cell growth and migration, whereas knockdown of SULF2 using short hairpin RNA targeting SULF2 abrogated HCC cell proliferation and migration in vitro. Because SULF1 and SULF2 desulfate heparan sulfate proteoglycans (HSPGs) and the HSPG glypican 3 (GPC3) is up-regulated in HCC, we investigated the effects of SULF2 on GPC3 expression and the association of SULF2 with GPC3. SULF2-mediated cell growth was associated with increased binding of fibroblast growth factor 2 (FGF2), phosphorylation of extracellular signal-regulated kinase and AKT, and expression of GPC3. Knockdown of GPC3 attenuated FGF2 binding in SULF2-expressing H CC cells. The effects of SULF2 on up-regulation of GPC3 and tumor growth were confirmed in nude mouse xenografts. Moreover, HCC patients with increased SULF2 expression in resected HCC tissues had a worse prognosis and a higher rate of recurrence after surgery. Conclusion: In contrast to the tumor suppressor effect of SULF1, SULF2 has an oncogenic effect in HCC mediated in part through up-regulation of FGF signaling and GPC3 expression. C1 [Lai, Jin-Ping; Sandhu, Dalbir S.; Han, Tao; Moser, Catherine D.; Jackson, Kenard K.; Guerrero, Ruben Bonilla; Aderca, Ileana; Isomoto, Hajime; Zou, Hongzhi; Shire, Abdirashid M.; Roberts, Lewis R.] Mayo Clin, Miles & Shirley Fiterman Ctr Digest Dis, Coll Med, Rochester, MN 55905 USA. [Yu, Chunrong; Adjei, Alex A.] Mayo Clin, Dept Oncol, Coll Med, Rochester, MN 55905 USA. [Garrity-Park, Megan M.; Sanderson, Schuyler O.] Mayo Clin, Dept Lab Med & Pathol, Coll Med, Rochester, MN 55905 USA. [Nagorney, David M.] Mayo Clin, Div Gastroenterol & Gen Surg, Coll Med, Rochester, MN 55905 USA. Mayo Clin Canc Ctr, Rochester, MN USA. [Thorgeirsson, Snorri S.] NCI, Expt Carcinogenesis Lab, Bethesda, MD 20892 USA. RP Lai, JP (reprint author), Mayo Clin, Miles & Shirley Fiterman Ctr Digest Dis, Coll Med, 200 1st St SW, Rochester, MN 55905 USA. EM lai.jinping@mayo.edu; roberts.lewis@mayo.edu OI Roberts, Lewis/0000-0001-7885-8574 FU NCI NIH HHS [K08 CA082862, CA100882, K08 CA082862-05, R01 CA100882, R01 CA100882-01A1, R01 CA100882-02, R01 CA100882-03, R01 CA100882-03S1, R01 CA100882-03S2, R01 CA100882-04, R01 CA100882-04S1, R01 CA100882-04S2, R01 CA100882-04S3, R01 CA100882-04S4, R01 CA100882-05, R01 CA100882-05S1, R01 CA100882-05S2, R01 CA100882-05S3, R56 CA100882] NR 32 TC 103 Z9 107 U1 0 U2 12 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD APR PY 2008 VL 47 IS 4 BP 1211 EP 1222 DI 10.1002/bep.22202 PG 12 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 283LG UT WOS:000254637100013 PM 18318435 ER PT J AU Lee, WM Squires, RH Nyberg, SL Doo, E Hoofnagle, JH AF Lee, William M. Squires, Robert H., Jr. Nyberg, Scott L. Doo, Edward Hoofnagle, Jay H. TI Acute liver failure: Summary of a workshop SO HEPATOLOGY LA English DT Editorial Material ID FULMINANT HEPATIC-FAILURE; HIGH-VOLUME PLASMAPHERESIS; SYNTHETIC EXTRACELLULAR MATRICES; UNCONTROLLED INTRACRANIAL HYPERTENSION; ACETAMINOPHEN-PROTEIN ADDUCTS; PROMISING TREATMENT MODALITY; BOUND SOLUTE DIALYSIS; EMBRYONIC STEM-CELLS; INTENSIVE-CARE-UNIT; B-VIRUS-INFECTION AB Acute liver failure (ALF) is a rare but challenging clinical syndrome with multiple causes; a specific etiology cannot be identified in 15% of adult and 50% of pediatric cases. The course of ALF is variable and the mortality rate is high. Liver transplantation is the only therapy of proven benefit, but the rapidity of progression and the variable course of ALF limit its use. Currently in the United States, spontaneous survival occurs in approximately 45%, liver transplantation in 25%, and death without transplantation in 30% of adults with ALF. Higher rates of spontaneous recovery (56%) and transplantation (31%) with lower rates of death (13%) occur in children. The outcome of ALF varies by etiology, favorable prognoses being found with acetaminophen overdose, hepatitis A, and ischemia (approximate to 60% spontaneous survival), and poor prognoses with drug-induced ALF, hepatitis B, and indeterminate cases (approximate to 25% spontaneous survival). Excellent intensive care is critical in management of patients with ALF. Nonspecific therapies are of unproven benefit. Future possible therapeutic approaches include N-acetylcysteine, hypothermia, liver assist devices, and hepatocyte transplantation. Advances in stem cell research may allow provision of cells for bioartificial liver support. ALF presents many challenging opportunities in both clinical and basic research. C1 [Lee, William M.] Univ Texas SW Med Ctr Dallas, Div Digest & Liver Dis, Dallas, TX 75390 USA. [Squires, Robert H., Jr.] Univ Pittsburgh, Childrens Hosp, Pittsburgh, PA 15260 USA. [Nyberg, Scott L.] Mayo Clin, Rochester, MN USA. [Doo, Edward; Hoofnagle, Jay H.] NIDDK, Liver Dis Res Branch, Div Digest Dis & Nutr, NIH, Bethesda, MD USA. RP Lee, WM (reprint author), Univ Texas SW Med Ctr Dallas, Div Digest & Liver Dis, 5959 harry Hines Blvd,Suite 420, Dallas, TX 75390 USA. EM William.Lee@utsouthwestern.edu FU NIDDK NIH HHS [R01 DK058369, U01 DK072146, R01 DK058369-05, U01 DK072146-05, U01-DK-072146, U01-DK-58639, U01 DK058369] NR 175 TC 268 Z9 294 U1 1 U2 14 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD APR PY 2008 VL 47 IS 4 BP 1401 EP 1415 DI 10.1002/hep.22177 PG 15 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 283LG UT WOS:000254637100032 PM 18318440 ER PT J AU Chander, G Josephs, J Fleishman, JA Korthuis, PT Gaist, P Hellinger, J Gebo, K AF Chander, G. Josephs, J. Fleishman, J. A. Korthuis, P. T. Gaist, P. Hellinger, J. Gebo, K. CA HIV Res Network TI Alcohol use among HIV-infected persons in care: results of a multi-site survey SO HIV MEDICINE LA English DT Article DE alcohol use; hazardous drinking; HIV; HIV Research Network; moderate alcohol use ID ACTIVE ANTIRETROVIRAL THERAPY; PRIMARY-HEALTH-CARE; UNITED-STATES; COLLABORATIVE PROJECT; SERVICES UTILIZATION; HEAVY DRINKING; CONSUMPTION; RISK; HARMFUL; MULTISTATE AB Objective We sought to determine the prevalence of any alcohol use and hazardous alcohol consumption among HIV-infected individuals engaged in care and to identify factors associated with hazardous alcohol use. Methods During 2003, 951 patients were interviewed at 14 HIV primary care sites in the USA. Hazardous drinking was defined as > 14 drinks/week or >= 5 drinks/occasion for men and > 7 drinks/week or >= 4 drinks/occasion for women. Moderate alcohol use was consumption at less than hazardous levels. We used logistic regression to identify factors associated with any alcohol use and hazardous alcohol use. Results Forty per cent of the sample reported any alcohol use in the 4 weeks prior to the interview; 11% reported hazardous use. In multivariate regression, male sex [adjusted odds ratio (AOR) 1.52 (95% confidence interval, CI, 1.07-2.16)], a college education (compared to < high school) [AOR 1.87 (1.10-3.18)] and illicit drug use [AOR 2.69 (1.82-3.95)] were associated positively with any alcohol use, while CD4 nadir >= 500 cells/mu L [AOR 2.65 (1.23-5.69)] and illicit drug use [AOR 2.67 (1.48-4.82)] were associated with increased odds of hazardous alcohol use (compared to moderate and none). Conclusions Alcohol use is prevalent among HIV-infected individuals and is associated with a variety of socioeconomic and demographic characteristics. Screening for alcohol use should be routine practice in HIV primary care settings. C1 [Chander, G.; Josephs, J.; Gebo, K.] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA. [Fleishman, J. A.] Agcy Hlthcare Res & Quality, Rockville, MD USA. [Korthuis, P. T.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [Gaist, P.] NIMH, Off AIDS Res, Bethesda, MD USA. [Hellinger, J.] Commun Med Alliance, Boston, MA USA. RP Chander, G (reprint author), 1830 E Monument St 8060, Baltimore, MD 21287 USA. EM gchande1@jhmi.edu RI Gebo, Kelly/B-9223-2009 FU NIAAA NIH HHS [K23 AA015313-04, K23 AA015313]; NIDA NIH HHS [K23-DA00523, K23 DA019809, K23 DA000523]; PHS HHS [290-01-0012] NR 31 TC 28 Z9 28 U1 1 U2 3 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1464-2662 J9 HIV MED JI HIV Med. PD APR PY 2008 VL 9 IS 4 BP 196 EP 202 DI 10.1111/j.1468-1293.2008.00545.x PG 7 WC Infectious Diseases SC Infectious Diseases GA 278SC UT WOS:000254305600003 PM 18366443 ER PT J AU Capparelli, EV Aweeka, F Hitti, J Stek, A Hu, C Burchett, SK Best, B Smith, E Read, JS Watts, H Nachman, N Thorpe, EM Spector, SA Jimenez, E Shearer, WT Foca, M Mirochnick, M AF Capparelli, E. V. Aweeka, F. Hitti, J. Stek, A. Hu, C. Burchett, S. K. Best, B. Smith, E. Read, J. S. Watts, H. Nachman, N. Thorpe, E. M., Jr. Spector, S. A. Jimenez, E. Shearer, W. T. Foca, M. Mirochnick, M. CA PACTG 1026S P1022 Study Teams TI Chronic administration of nevirapine during pregnancy: impact of pregnancy on pharmacokinetics SO HIV MEDICINE LA English DT Article DE HIV; nevirapine; non-nucleoside reverse transcriptase; pharmacokinetics; pregnancy ID HIV-1-INFECTED INDIVIDUALS; VIROLOGICAL RESPONSE; PROTEASE INHIBITORS; WOMEN; EXPOSURE; BIOTRANSFORMATION; COMBINATION; LOPINAVIR; DELIVERY; THERAPY AB Objectives To determine the impact of pregnancy on the pharmacokinetics (PK) of nevirapine (NVP) during chronic dosing in HIV-infected women and appropriate NVP dosing in this population. Methods Twenty-six pregnant women participating in two open-label Pediatric AIDS Clinical Trials Group studies (P1022 and P1026S) were evaluated. Each patient received 200 mg NVP every 12 h and had PK evaluations during the second or third trimester; these evaluations were repeated postpartum. Paired maternal and cord blood NVP concentrations were collected at delivery in nine patients. Ante- and postpartum comparisons were made using paired t-tests and using a 'bioequivalence' approach to determine confidence interval (CI). Results The average NVP Area Under the Curve (AUC) was 56 +/- 13 mcg(*)h/mL antepartum and 61 +/- 15 mcg(*)h/mL postpartum. The typical parameters +/- standard error were apparent clearance (CL/F)=3.51 +/- 0.18 L/h and apparent volume of distribution (Vd/F)=121 +/- 19.8 L. There were no significant differences between antepartum and postpartum AUC or pre-dose concentrations. The AUC ratio was 0.90 with a 90% CI of the mean equal to 0.80-1.02. The median (+/- standard deviation) cord blood to maternal NVP concentration ratio was 0.91 +/- 0.90. Conclusions Pregnancy does not alter NVP PK and the standard dose (200 mg every 12 h) is appropriate during pregnancy. C1 [Capparelli, E. V.; Best, B.] Univ Calif San Diego, San Diego Sch Med, San Diego, CA USA. [Capparelli, E. V.; Best, B.] Univ Calif San Diego, San Diego Sch Pharm & Pharmaceuit Sci, San Diego, CA USA. [Aweeka, F.] Univ Calif San Francisco, San Francisco Sch Pharm, San Francisco, CA 94143 USA. [Hitti, J.] Univ Washington, Seattle, WA 98195 USA. [Stek, A.] Univ So Calif, Sch Med, Dept Obstet & Gynecol, Los Angeles, CA USA. [Hu, C.] Harvard Univ, Sch Publ Hlth, Statist & Data Anal Ctr, Boston, MA 02115 USA. [Burchett, S. K.] Childrens Hosp, Boston, MA USA. [Smith, E.] NAID, Bethesda, MD USA. [Read, J. S.; Watts, H.] NIH, NICHD, Pediat Adolescent & Maternal AIDS Branch, DHHS, Bethesda, MD USA. [Nachman, N.] HSC SUNY, Stony Brook, NY USA. [Thorpe, E. M., Jr.] Univ Tennessee, Childrens Hosp, Memphis, TN USA. [Jimenez, E.] City Hosp, San Juan, PR USA. [Shearer, W. T.] Texas Childrens Hosp, Baylor Coll Med, Houston, TX 77030 USA. [Foca, M.] Columbia Univ, Coll Phys & Surg, New York, NY USA. [Mirochnick, M.] Boston Univ, Boston, MA 02215 USA. RP Capparelli, EV (reprint author), Univ Calif San Diego, Pediat Pharmacol Res Unit, 200 Arbor Dr MC 8214, San Diego, CA 92103 USA. EM ecapparelli@ucsd.edu RI Hu, Chengcheng/A-8391-2017 FU NIAID NIH HHS [U01AI41089, U01 AI041089, U01 AI04189, U01 AI068632-03, UM1 AI069477]; NICHD NIH HHS [N01-HD-3-3365, U10 HD031318, U10-HD-031318-11] NR 24 TC 27 Z9 27 U1 0 U2 1 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1464-2662 J9 HIV MED JI HIV Med. PD APR PY 2008 VL 9 IS 4 BP 214 EP 220 DI 10.1111/j.1468-1293.2008.00553.x PG 7 WC Infectious Diseases SC Infectious Diseases GA 278SC UT WOS:000254305600006 PM 18366444 ER PT J AU Tu, L Xu, XZ Wan, HB Zhou, CQ Deng, JJ Xu, G Xiao, X Chen, YP Edin, ML Voltz, JW Zeldin, DC Wang, DW AF Tu, Ling Xu, Xizhen Wan, Huaibing Zhou, Changqing Deng, Juanjuan Xu, Gang Xiao, Xiao Chen, Yipu Edin, Matthew L. Voltz, James W. Zeldin, Darryl C. Wang, Dao Wen TI Delivery of recombinant adeno-associated virus-mediated human tissue kallikrein for therapy of chronic renal failure in rats SO HUMAN GENE THERAPY LA English DT Article ID BRADYKININ B-2 RECEPTOR; SALT-SENSITIVE RATS; ATTENUATES HYPERTENSION; MOLECULAR-MECHANISMS; TRANSGENIC MICE; ANGIOTENSIN-II; KININ SYSTEM; EXPRESSION; INJURY; VECTORS AB The tissue kallikrein - kinin system is important in regulating cardiovascular and renal function, and dysregulation of the system has been implicated in heart and kidney pathologies. These findings suggest that if balance can be restored to the kallikrein - kinin axis, then associated disease progression may be attenuated. To test this hypothesis, recombinant adeno-associated virus (rAAV)-mediated human tissue kallikrein (HK) expression was induced in a rodent model of chronic renal failure involving 5/6 nephrectomy (nephrectomy plus 70% reduction of remaining kidney). rAAV-HK treatment attenuated the rise in blood pressure, glomerular sclerosis, and tubulointerstitial injury observed in this model. rAAV-HK treatment also attenuated renal function decline as measured by urinary microalbumin, osmolarity, and cGMP levels. Reverse transcriptase-polymerase chain reaction analysis showed that rAAV-HK-treated rats had higher levels of bradykinin receptor-2 (B2R) and dopamine receptor-1 mRNAs. In contrast, angiotensin II receptor-1, endothelin receptor-A, and vasopressin receptor-2 mRNAs were markedly downregulated in kidneys from HK-treated rats. Bradykinin induced similar changes in receptor levels and prevented transforming growth factor-beta(1)-induced tubulointerstitial fibrosis. The effects of bradykinin could be reversed with the B2R antagonist HOE-140. Together, these findings suggest that restoration of the kallikrein - kinin system reduces kidney injury and protects renal function in 5/6-nephrectomized rats via changes in the expression and activation of G protein-coupled receptors including B2R. C1 [Tu, Ling; Xu, Xizhen; Wan, Huaibing; Zhou, Changqing; Deng, Juanjuan; Xu, Gang; Xiao, Xiao; Wang, Dao Wen] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Internal Med, Wuhan 430030, Peoples R China. [Tu, Ling; Xu, Xizhen; Wan, Huaibing; Zhou, Changqing; Deng, Juanjuan; Xu, Gang; Xiao, Xiao; Wang, Dao Wen] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Inst Hypertens, Wuhan 430030, Peoples R China. [Chen, Yipu] China Japan Friendship Hosp, Dept Internal Med, Beijing 100029, Peoples R China. [Edin, Matthew L.; Voltz, James W.; Zeldin, Darryl C.] NIEHS, Natl Inst Hlth, Div Intramural Res, Res Triangle Pk, NC 27709 USA. RP Wang, DW (reprint author), Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Internal Med, 1095 Jiefang Ave, Wuhan 430030, Peoples R China. EM dwwang@tjh.tjmu.edu.cn OI Edin, Matthew/0000-0002-7042-500X FU Intramural NIH HHS [Z01 ES025034-13] NR 50 TC 23 Z9 28 U1 0 U2 4 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1043-0342 J9 HUM GENE THER JI Hum. Gene Ther. PD APR PY 2008 VL 19 IS 4 BP 318 EP 330 DI 10.1089/hum.2007.138 PG 13 WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine, Research & Experimental SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research & Experimental Medicine GA 293SP UT WOS:000255355300002 PM 18402547 ER PT J AU Parker, AL McVey, JH Waddington, SN Buckley, SMK Francischetti, IMB Monteiro, RQ Nicklin, SA Baker, AH AF Parker, A. L. McVey, J. H. Waddington, S. N. Buckley, S. M. K. Francischetti, I. M. B. Monteiro, R. Q. Nicklin, S. A. Baker, A. H. TI An exosite within the human FX serine protease domain mediates cell transduction of AD5: FX complexes SO HUMAN GENE THERAPY LA English DT Meeting Abstract CT 5th Annual Conference of the British-Society-for-Gene-Therapy CY APR 07-09, 2008 CL Edinburgh, SCOTLAND SP British Soc Gene Therapy C1 [Parker, A. L.; Baker, A. H.] BHF Glasgow Cardiovasc Res Ctr, Glasgow, Lanark, Scotland. [McVey, J. H.] Univ London Imperial Coll Sci Technol & Med, MRC Clin Sci Ctr, London SW7 2AZ, England. [Waddington, S. N.; Buckley, S. M. K.] Haemophilia Ctr, Dept Haematol, London, England. [Waddington, S. N.; Buckley, S. M. K.] UCL Royal Free & Univ Coll Med Sch, Haemostasis Unit, London, England. [Francischetti, I. M. B.] NIAID, NIH, Lab Malaria & Vector Res, Rockville, MD USA. [Monteiro, R. Q.] Univ Fed Rio de Janeiro, Inst Bioquim, BR-21941 Rio De Janeiro, Brazil. RI Parker, Alan/B-8187-2009 OI Parker, Alan/0000-0002-9302-1761 NR 1 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1043-0342 J9 HUM GENE THER JI Hum. Gene Ther. PD APR PY 2008 VL 19 IS 4 MA P34 BP 407 EP 407 PG 1 WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine, Research & Experimental SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research & Experimental Medicine GA 293SP UT WOS:000255355300043 ER PT J AU Waddington, SN Mcvey, JH Bhella, D Parker, AL Barker, K Atoda, K Pink, R Buckley, SMK Greig, JA Denby, L Custers, J Morita, T Francischetti, IMB Monteiro, RQ Barouch, DH van Rooijen, N Napoli, C Havenga, M Nicklin, SA Baker, AH AF Waddington, S. N. Mcvey, J. H. Bhella, D. Parker, A. L. Barker, K. Atoda, K. Pink, R. Buckley, S. M. K. Greig, J. A. Denby, L. Custers, J. Morita, T. Francischetti, I. M. B. Monteiro, R. Q. Barouch, D. H. van Rooijen, N. Napoli, C. Havenga, M. Nicklin, S. A. Baker, A. H. TI A critical role for the adenovirus serotype 5 hexon in liver gene transfer SO HUMAN GENE THERAPY LA English DT Meeting Abstract CT 5th Annual Conference of the British-Society-for-Gene-Therapy CY APR 07-09, 2008 CL Edinburgh, SCOTLAND SP British Soc Gene Therapy C1 [Waddington, S. N.; Buckley, S. M. K.] UCL Royal Free & Univ Coll Med Sch, Haemostasis Unit, London, England. [Waddington, S. N.; Buckley, S. M. K.] Haemophilia Ctr, Dept Haematol, London, England. [Mcvey, J. H.] Univ London Imperial Coll Sci Technol & Med, MRC, Ctr Clin Sci, London SW7 2AZ, England. [Bhella, D.; Pink, R.] Univ Glasgow, Virol Unit, MRC, Glasgow, Lanark, Scotland. [Parker, A. L.; Barker, K.; Greig, J. A.; Denby, L.; Baker, A. H.] Univ Glasgow, Glasgow Cardiovasc Res Ctr, British Heart Fdn, Glasgow, Lanark, Scotland. [Atoda, K.; Morita, T.] Meiji Pharmaceut Univ, Dept Biochem, Tokyo, Japan. [Francischetti, I. M. B.] NIAID, NIH, Lab Malaria & Vector Res, Rockville, MD USA. [Custers, J.; Havenga, M.] Crucell, Leiden, Netherlands. [Monteiro, R. Q.] Univ Fed Rio de Janeiro, Inst Bioquim, BR-21941 Rio De Janeiro, Brazil. [Barouch, D. H.] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Viral Pathogenesis, Boston, MA USA. [van Rooijen, N.] Vrije Univ Amsterdam, VUMC, Dept Mol Cell Biol, Amsterdam, Netherlands. [Napoli, C.] Univ Naples 2, Dept Gen Pathol, Naples, Italy. [Napoli, C.] Temple Univ, Coll Sci & Technol, Sbarri Inst Canc Res & Mol Med, Philadelphia, PA 19122 USA. RI Parker, Alan/B-8187-2009; Bhella, David/J-8514-2012; OI Parker, Alan/0000-0002-9302-1761; bhella, david/0000-0003-2096-8310 NR 0 TC 0 Z9 0 U1 1 U2 2 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1043-0342 J9 HUM GENE THER JI Hum. Gene Ther. PD APR PY 2008 VL 19 IS 4 MA P40 BP 409 EP 409 PG 1 WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine, Research & Experimental SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research & Experimental Medicine GA 293SP UT WOS:000255355300049 ER PT J AU Paisan-Ruiz, C Nath, P Washecka, N Gibbs, JR Singleton, AB AF Paisan-Ruiz, Coro Nath, Priti Washecka, Nicole Gibbs, J. Raphael Singleton, Andrew B. TI Comprehensive analysis of LRRK2 in publicly available Parkinson's disease cases and neurologically normal controls SO HUMAN MUTATION LA English DT Article DE LRRK2; association studies; linkage disequilibrium; tagging SNPs; Parkinson's disease ID AUTOSOMAL-DOMINANT PARKINSONISM; G2019S MUTATION; COMMON FOUNDER; EARLY-ONSET; ASSOCIATION; GENE; COHORT; FREQUENCY; VARIANTS; FAMILIES AB Mutation of LRRK2, encoding dardarin, is the most common known genetic cause of Parkinson's disease (PD). The large size of this gene and the relative ease with which the most common mutations can be screened means that although more than 50 LRRK2 screening papers have been published, few have analyzed the entire coding sequence. Furthermore, no comprehensive sequence,based analysis has been performed on control samples. Here, we present sequencing of all coding exons in a series of 275 PD cases and 275 neurologically normal controls and analysis of the LRRK2 locus for whole gene multiplications or deletions. We also present case-control SNP association results using 74 SNPs genotyped across LRRK2. We identified six novel disease-associated missense mutations, including two that altered the same residue of the protein. These data and analysis of previously reported disease. segregating mutations shows that the majority of disease-causing mutations lie in the C-terminal half of the protein. C1 [Paisan-Ruiz, Coro; Nath, Priti; Washecka, Nicole; Singleton, Andrew B.] NIA, Mol Genet Unit, NIH, Bethesda, MD 20892 USA. [Gibbs, J. Raphael] NIA, Neurogenet Lab, NIH, Bethesda, MD 20892 USA. [Gibbs, J. Raphael] Dept Mol Neurosci, London, England. [Gibbs, J. Raphael] Inst Neurol, Reta Lila Weston Labs, London WC1N 3BG, England. [Gibbs, J. Raphael] Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, England. [Gibbs, J. Raphael] Inst Neurol, Dept Neurodegenerat Dis, London WC1N 3BG, England. RP Paisan-Ruiz, C (reprint author), NIA, Mol Genet Unit, NIH, Bethesda, MD 20892 USA. EM C.Paisan-Ruiz@ion.ucl.ac.uk RI Paisan-Ruiz, Coro/C-2912-2009; Gibbs, J. Raphael/A-3984-2010; Singleton, Andrew/C-3010-2009 FU Intramural NIH HHS NR 28 TC 57 Z9 59 U1 1 U2 4 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1059-7794 J9 HUM MUTAT JI Hum. Mutat. PD APR PY 2008 VL 29 IS 4 BP 485 EP 490 DI 10.1002/humu.20668 PG 6 WC Genetics & Heredity SC Genetics & Heredity GA 285TZ UT WOS:000254800400006 PM 18213618 ER PT J AU Riazuddin, S Nazli, S Ahmed, ZM Yang, Y Zulfiqar, F Shaikh, RS Zafar, AU Khan, SN Sabar, F Javid, FT Wilcox, ER Tsilou, E Boger, ET Sellers, JR Belyantseva, IA Riazuddin, S Friedmanl, TB AF Riazuddin, Saima Nazli, Sabiha Ahmed, Zubair M. Yang, Yi Zulfiqar, Fareeha Shaikh, Rehan S. Zafar, Ahmed U. Khan, Shaheen N. Sabar, Farooq Javid, Fouzia T. Wilcox, Edward R. Tsilou, Ekaterini Boger, Erich T. Sellers, James R. Belyantseva, Inna A. Riazuddin, Sheikh Friedmanl, Thomas B. TI Mutation spectrum of MYO7A and evaluation of a novel nonsyndromic deafness DFNB2 allele with residual function SO HUMAN MUTATION LA English DT Article DE deafness; nonsyndromic hearing loss; DFNB2; MYO7A; Usher syndrome; hair cell; stereocilia ID MYOSIN-VIIA GENE; USHER 1B SYNDROME; SYNDROME TYPE 1F; RECESSIVE DEAFNESS; MOTOR DOMAIN; HAIR-CELLS; HETEROGENEITY; PROTEIN; FAMILY; PCDH15 AB Recessive mutations of MYO7A, encoding unconventional myosin VIIA,, can cause either a deaf-blindness syndrome (type 1 Usher syndrome; USH1B) or nonsyndromic deafness (DFNB2). In our study, deafness segregating as a recessive trait in 24 consanguineous families showed linkage to markers for the DFNB2/USH1B locus on chromosome 11q13.5. A total of 23 of these families segregate USH1 due to 17 homozygous mutant MYO7A alleles, of which 14 are novel. One family segregated nonsyndromic hearing loss DFNB2 due to a novel three-nucleotide deletion in an exon of MYO7A (p.E1716del) encoding a region of the tail domain. We hypothesized that DFNB2 alleles of MYO7A have residual myosin VIIA. To address this question we investigated the effects of several mutant alleles by making green fluorescent protein (GFP) tagged cDNA expression constructs containing engineered mutations of mouse Myo7a at codons equivalent to pathogenic USH1B and DFNB2 alleles of human MYO7A. We show that in transfected mouse hair cells an USH1B mutant GFP-myosin VIIa does not localize properly to inner ear hair cell stereocilia. However, a GFP-myosin VIIa protein engineered to have an equivalent DFNB2 mutation to p.E1716del localizes correctly in transfected mouse hair cells. This finding is consistent with the hypothesis that p.E1716del causes a less severe phenotype (DFNB2) than the USH1B-associated alleles because the resulting protein retains some degree of normal function. C1 [Riazuddin, Saima; Ahmed, Zubair M.; Wilcox, Edward R.; Boger, Erich T.; Belyantseva, Inna A.; Friedmanl, Thomas B.] NIDCD, Sect Human Genet, Genet Mol Lab, NIH, Rockville, MD 20850 USA. [Nazli, Sabiha; Zulfiqar, Fareeha; Shaikh, Rehan S.; Zafar, Ahmed U.; Khan, Shaheen N.; Sabar, Farooq; Javid, Fouzia T.; Riazuddin, Sheikh] Univ Punjab, Natl Ctr Excellence Mol Biol, Lahore, Pakistan. [Yang, Yi; Sellers, James R.] NHLBI, Mol Pathophysiol Lab, NIH, Bethesda, MD 20892 USA. [Tsilou, Ekaterini] NEI, Opthalm Genet & Visual Funct Branch, NIH, Bethesda, MD 20892 USA. [Boger, Erich T.] Univ Maryland, Dept Biol, College Pk, MD 20742 USA. RP Friedmanl, TB (reprint author), NIDCD, Sect Human Genet, Genet Mol Lab, NIH, 5 Res Court,Room 2A-19, Rockville, MD 20850 USA. EM friedman@nidcd.nih.gov RI Shaikh, Rehan Sadiq/B-9101-2009; Nasim Khan, Shaheen/F-2135-2015; SHEIKH, RIAZUDDIN/L-2406-2015 FU Intramural NIH HHS NR 42 TC 48 Z9 50 U1 0 U2 1 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1059-7794 J9 HUM MUTAT JI Hum. Mutat. PD APR PY 2008 VL 29 IS 4 BP 502 EP 511 DI 10.1002/humu.20677 PG 10 WC Genetics & Heredity SC Genetics & Heredity GA 285TZ UT WOS:000254800400008 PM 18181211 ER PT J AU Emaus, A Espetvedt, S Veierod, MB Ballard-Barbash, R Furberg, AS Ellison, PT Jasienska, G Hjartaker, A Thune, I AF Emaus, A. Espetvedt, S. Veierod, M. B. Ballard-Barbash, R. Furberg, A. -S. Ellison, P. T. Jasienska, G. Hjartaker, A. Thune, I. TI 17-beta-Estradiol in relation to age at menarche and adult obesity in premenopausal women SO HUMAN REPRODUCTION LA English DT Article DE 17-beta-estradiol; age at menarche; adult body fatness; breast cancer risk; Norway ID BREAST-CANCER RISK; BODY-MASS INDEX; PHYSICAL-ACTIVITY; POSTMENOPAUSAL WOMEN; MENSTRUAL-CYCLE; SEX-HORMONES; REPRODUCTIVE FACTORS; ESTROGEN EXPOSURE; ADOLESCENT GIRLS; FAT DISTRIBUTION AB BACKGROUND: We hypothesize that premenopausal endogenous estradiol may be associated with age at menarche and adult overweight and obesity, potentially contributing to breast cancer risk. METHODS: We assessed age at menarche by questionnaire among 204 healthy Norwegian women, aged 25-35 years. Measures of body composition included body mass index (BMI, kg/m(2)), waist circumference (WC, cm), waist-to-hip ratio (WHR) and fat percentage dual energy X-ray absorptiometry, (DEXA). Daily salivary 17-beta-estradiol (E-2) concentrations were collected throughout one entire menstrual cycle and assessed by radioimmunoassay (RIA). Linear regression analyses and linear mixed models for repeated measures were used and potential confounding factors and effect modifiers were tested. RESULTS: Among women with an early age at menarche (<= 12 years), the overall mean salivary E-2 concentration increased by 3.7 pmol/l (95% confidence interval, 1.8-5.7 pmol/l) with each 9.8 cull (1SD) increase in WC, which represents a 20.7% change in the mean for the total group. Among the same early maturers, a 1SD (0.06) change in WHR was directly associated with a 24.0% change in mean E-2 concentration for the total group. CONCLUSIONS: Our findings support the hypothesis that early age at menarche, together with adult overweight and obesity, result in high levels of 17-beta-estradiol throughout the menstrual cycle. C1 [Emaus, A.; Espetvedt, S.; Thune, I.] Ullevaal Univ Hosp, Dept Oncol, Oslo 0407, Norway. [Veierod, M. B.] Univ Oslo, Inst Basic Med Sci, Dept Biostat, Oslo, Norway. [Ballard-Barbash, R.] NCI, Div Canc Control & Populat Sci, Appl Res Program, Bethesda, MD 20892 USA. [Furberg, A. -S.] Univ Hosp N Norway, Dept Microbiol & Infect Control, NORM Surveillance Program Antimicrobial Resistanc, N-9038 Tromso, Norway. [Furberg, A. -S.] Univ Tromso, Fac Med, Inst Commun Med, N-9037 Tromso, Norway. [Ellison, P. T.] Harvard Univ, Dept Anthropol, Cambridge, MA 02138 USA. [Jasienska, G.] Jagiellonian Univ, Coll Med, Dept Epidemiol & Populat Studies, Krakow, Poland. [Hjartaker, A.] Canc Registry Norway, Inst Populat Based Canc Res, N-0310 Oslo, Norway. [Thune, I.] Res Council Norway, N-0131 Oslo, Norway. RP Emaus, A (reprint author), Ullevaal Univ Hosp, Dept Oncol, Oslo 0407, Norway. EM aina.emaus@medisin.uio.no RI Hjartaker, Anette/D-6220-2011; OI Veierod, Marit B./0000-0002-2083-2758 NR 45 TC 39 Z9 39 U1 0 U2 2 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0268-1161 J9 HUM REPROD JI Hum. Reprod. PD APR PY 2008 VL 23 IS 4 BP 919 EP 927 DI 10.1093/humrep/dem432 PG 9 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 296OG UT WOS:000255555100027 PM 18227106 ER PT J AU Hiby, SE Regan, L Lo, W Farrell, L Carrington, M Moffett, A AF Hiby, S. E. Regan, L. Lo, W. Farrell, L. Carrington, M. Moffett, A. TI Association of maternal killer-cell immunoglobulin-like receptors and parental HLA-C genotypes with recurrent miscarriage SO HUMAN REPRODUCTION LA English DT Article DE recurrent miscarriage; natural killer cells; HLA-C; trophoblast; killei-immunoglobulin-like receptor ID 3 ETHNIC-GROUPS; SPONTANEOUS-ABORTION; TRIMESTER MISCARRIAGE; EARLY-PREGNANCY; PREECLAMPSIA; PLACENTATION; POPULATION; GENES; ALLELES; KIR2DL4 AB BACKGROUND: The natural killer (NK) cells at the site of placentation express killer-cell immunoglobulin-like receptors (KIR) that can bind to human leukocyte antigen (HLA)-C molecules on trophoblast cells. Both these gene systems are polymorphic and an association of particular maternal KIR/fetal HLA-C genotypes has been shown in pre-eclampsia. Pre-eclampsia and recurrent miscarriage (RM) share the pathogenesis of defective placentation and therefore we have now genotyped couples with RM. METHODS AND RESULTS: DNA was obtained from the male (n = 67) and female (n = 95) partners of couples with three or more spontaneous miscarriages and genotyped for HLA-C groups and 11 KIR genes using the PCR-sequence-specific primer method (SSP). The frequency of the HLA-C2 group was increased in both parents (reaching significance only in the male partners, P = 0.018) compared with a parous control population. The KIR gene frequencies of the male partners were similar to controls, but the women had a high frequency of KIR AA haplotypes that lack activating KIR. In particular, the activating KIR for HLA-C2 groups (KIR2DS1) was significantly lower in these women (P = 0.00035, odds ratio 2.63, confidence interval 1.54-4.49). CONCLUSIONS: This is the first report to identify a genetic male factor that confers risk in RM. These findings support the idea that successful placentation depends on the correct balance of NK cell inhibition and activation in response to trophoblast. C1 [Hiby, S. E.; Farrell, L.; Moffett, A.] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England. [Regan, L.; Lo, W.] St Marys Hosp, Sch Med, Dept Obstet & Gynecol, London W2 1PG, England. [Carrington, M.] SAIC Frederick Inc, NCI Frederick, Lab Genome Divers, Ft Detrick, MD 21702 USA. RP Moffett, A (reprint author), Univ Cambridge, Dept Pathol, Tennis Court Rd, Cambridge CB2 1QP, England. EM am485@cam.ac.uk OI Farrell, Lydia/0000-0002-7643-6009 FU British Heart Foundation; Intramural NIH HHS; NCI NIH HHS [N01-CO-12400]; Wellcome Trust NR 38 TC 137 Z9 149 U1 2 U2 8 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0268-1161 J9 HUM REPROD JI Hum. Reprod. PD APR PY 2008 VL 23 IS 4 BP 972 EP 976 DI 10.1093/humrep/den011 PG 5 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 296OG UT WOS:000255555100034 PM 18263639 ER PT J AU Wassertheil-Smoller, S Kooperberg, C McGinn, AP Kaplan, RC Hsia, J Hendrix, SL Manson, JE Berger, JS Kuller, LH Allison, MA Baird, AE AF Wassertheil-Smoller, Sylvia Kooperberg, Charles McGinn, Aileen P. Kaplan, Robert C. Hsia, Judith Hendrix, Susan L. Manson, JoAnn E. Berger, Jeffrey S. Kuller, Lewis H. Allison, Matthew A. Baird, Alison E. TI Lipoprotein-associated phospholipase A(2), hormone use, and the risk of ischemic stroke in postmenopausal women SO HYPERTENSION LA English DT Article DE stroke; lipoprotein; associated phospholipase A(2); Lp-PLA(2); postmenopausal women; stroke biomarkers; hormones; Women's Health Initiative; WHI ID RANDOMIZED CONTROLLED-TRIAL; ESTROGEN PLUS PROGESTIN; CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; MIDDLE-AGED MEN; EQUINE ESTROGEN; ATHEROSCLEROSIS; EVENTS AB Few studies have investigated the role of elevated lipoprotein-associated phospholipase A2 (Lp-PLA2) with stroke risk, and those that have are based on small numbers of strokes. No study has evaluated the effect of hormone therapy use on the association of Lp-PLA2 and stroke. We assessed the relationship between Lp-PLA2 and the risk of incident ischemic stroke in 929 stroke patients and 935 control subjects in the Hormones and Biomarkers Predicting Stroke Study, a nested case-control study from the Women's Health Initiative Observational Study. Mean (SD) levels of Lp-PLA2 were significantly higher among case subjects (309.0 [97.1]) than control subjects (296.3 [87.3]; P < 0.01). Odds ratio for ischemic stroke for the highest quartile of Lp-PLA2, compared with lowest, controlling for multiple covariates, was 1.08 (95% CI: 0.75 to 1.55). However, among 1137 nonusers of hormone therapy at baseline, the corresponding odds ratio was 1.55 (95% CI: 1.05 to 2.28), whereas there was no significant association among 737 hormone users (odds ratio: 0.70; 95% CI: 0.42 to 1.17; P for interaction = 0.055). Moreover, among nonhormone users, women with high C-reactive protein and high Lp-PLA2 had more than twice the risk of stroke (odds ratio: 2.26; 95% CI: 1.55 to 3.35) compared with women low levels in both biomarkers. Furthermore, different stroke cases were identified as high risk by Lp-PLA2 rather than by C-reactive protein. Lp-PLA2 was associated with incident ischemic stroke independently of C-reactive protein and traditional cardiovascular risk factors among nonusers of hormone therapy with highest risk in those who had both high C-reactive protein and high Lp-PLA2. C1 [Wassertheil-Smoller, Sylvia; McGinn, Aileen P.; Kaplan, Robert C.] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA. [Kooperberg, Charles] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Hsia, Judith] AstraZeneca, Wilmington, DE USA. [Hendrix, Susan L.] Wayne State Univ, Sch Med, Hutzel Womens Hosp, Dept Obstet & Gynecol, Detroit, MI USA. [Manson, JoAnn E.] Brigham & Womens Hosp, Harvard Med Sch, Div Prevent Med, Boston, MA 02115 USA. [Berger, Jeffrey S.] Duke Univ, Dept Cardiovasc Med, Durham, NC USA. [Kuller, Lewis H.] Univ Pittsburgh, Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA. [Allison, Matthew A.] Univ Calif San Diego, Dept Family & Prevent Med, San Diego, CA 92103 USA. [Baird, Alison E.] Natl Inst Neurol Disorders & Stroke, Stroke Neurosci Unit, Bethesda, MD USA. RP Wassertheil-Smoller, S (reprint author), Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, 1300 Morris Pk Ave,Belfer 1312A, Bronx, NY 10467 USA. EM smoller@aecom.yu.edu RI Kaplan, Robert/A-2526-2011; OI Allison, Matthew/0000-0003-0777-8272 NR 20 TC 34 Z9 38 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0194-911X J9 HYPERTENSION JI Hypertension PD APR PY 2008 VL 51 IS 4 BP 1115 EP 1122 DI 10.1161/HYPERTENSIONAHA.107.103721 PG 8 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 276SA UT WOS:000254161300055 PM 18259035 ER PT J AU Mitchell, GF Gudnason, V Launer, LJ Aspelund, T Harris, TB AF Mitchell, Gary F. Gudnason, Vilmundur Launer, Lenore J. Aspelund, Thor Harris, Tamara B. TI Hemodynamics of increased pulse pressure in older women in the community-based age, Gene/Environment susceptibility-reykjavik study SO HYPERTENSION LA English DT Article DE hypertension; hemodynamics; pulse pressure; aorta; vascular stiffness; pulse wave velocity ID SPONTANEOUSLY HYPERTENSIVE-RATS; AORTIC INPUT IMPEDANCE; CORONARY-HEART-DISEASE; ARTERIAL STIFFNESS; SYSTOLIC HYPERTENSION; PULSATILE HEMODYNAMICS; WAVE REFLECTION; DIAMETER; RISK; VELOCITY AB Pulse pressure increases with advancing age particularly in women. As a result, women have a higher pulse pressure than men from midlife onward. Higher pulse pressure in older women as compared to men is often attributed to increased aortic wall stiffness and premature wave reflection. To evaluate this hypothesis, we measured central aortic input impedance, pulse wave velocity, and wave reflection in 408 older men and women (age range, 69 to 94 yr, mean 75 yr) participating in the community-based Age, Gene/Environment Susceptibility-Reykjavik Study (AGES-Reykjavik). Women as compared to men had higher pulse pressure (75.8 +/- 18.7 versus 69.5 +/- 16.8 mm Hg, P < 0.001) and smaller aortic diameters (2.74 +/- 0.24 versus 2.97 +/- 0.28 cm, P < 0.001). Augmentation index (AI) was higher (11.0 +/- 15.9 versus 7.9 +/- 12.9%, P = 0.032) in women whereas proximal aortic elastance-wall thickness product ( Eh) did not differ (P = 0.61). In a stepwise model for pulse pressure that included age and sex and offered aortic diameter, Eh, mean pressure, AI, pulse wave velocity, height, weight, and body surface area as additional covariates, higher pulse pressure was associated with increased wall stiffness, smaller aortic diameter, higher mean pressure, and increased AI (Model R(2) = 0.59, P < 0.001). The sex difference in pulse pressure (6.6 +/- 1.7 mm Hg, P < 0.001) persisted after Eh entered the model (6.9 +/- 1.5 mm Hg, P < 0.001) but not after aortic diameter entered the model (-0.4 +/- 1.4 mm Hg, P = 0.75). Thus, reduced aortic diameter and impaired matching between diameter and flow accounts for the sex difference in pulse pressure in an unselected community-based cohort of older people. C1 [Mitchell, Gary F.] Cardiovasc Engn Inc, Waltham, MA 02453 USA. [Gudnason, Vilmundur; Aspelund, Thor] Iceland Heart Assoc, Kopavogur, Iceland. [Launer, Lenore J.; Harris, Tamara B.] NIH, NIA, Bethesda, MD 20892 USA. RP Mitchell, GF (reprint author), Cardiovasc Engn Inc, 51 Sawyer Rd,Suite 100, Waltham, MA 02453 USA. EM GaryFMitchell@mindspring.com RI Aspelund, Thor/C-5983-2008; Aspelund, Thor/F-4826-2011; Gudnason, Vilmundur/K-6885-2015 OI Aspelund, Thor/0000-0002-7998-5433; Gudnason, Vilmundur/0000-0001-5696-0084 FU Intramural NIH HHS; NIA NIH HHS [N01-AG-12100] NR 29 TC 38 Z9 39 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0194-911X J9 HYPERTENSION JI Hypertension PD APR PY 2008 VL 51 IS 4 BP 1123 EP 1128 DI 10.1161/HYPERTENSIONAHA.107.108175 PG 6 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 276SA UT WOS:000254161300056 PM 18259005 ER PT J AU Maia, AL Hwang, SJ Levy, D Larson, MG Larsen, PR Fox, CS AF Maia, Ana Luiza Hwang, Shih-Jen Levy, Daniel Larson, Martin G. Larsen, P. Reed Fox, Caroline S. TI Lack of association between the type 2 deiodinase A/G polymorphism and hypertensive traits: The framingham heart study SO HYPERTENSION LA English DT Letter ID DIABETES-MELLITUS PATIENTS; THR92ALA POLYMORPHISM; ARTERIAL-HYPERTENSION C1 [Maia, Ana Luiza] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Div Endocrine, Thyroid Sect, Porto Alegre, RS, Brazil. [Hwang, Shih-Jen; Levy, Daniel; Fox, Caroline S.] NHLBI, Framingham Heart Study, Framingham, MA USA. [Larson, Martin G.] Boston Univ, Sch Med, Boston, MA 02118 USA. [Larsen, P. Reed] Harvard Univ, Sch Med, Boston, MA 02115 USA. [Larsen, P. Reed; Fox, Caroline S.] Brigham & Womens Hosp, Div Endocrinol Diabet & Hypertens, Boston, MA 02115 USA. [Fox, Caroline S.] NHLBI, Ctr Populat Studies, Bethesda, MD USA. RP Maia, AL (reprint author), Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Div Endocrine, Thyroid Sect, Porto Alegre, RS, Brazil. RI Maia, Ana Luiza/F-9201-2012; OI Maia, Ana Luiza/0000-0002-4186-5532; Larson, Martin/0000-0002-9631-1254 FU FIC NIH HHS [FIC TW007559, R03 TW007559, R03 TW007559-01A1]; NHLBI NIH HHS [N01 HC025195, N01-HC-25195]; NIDDK NIH HHS [DK 36256, R01 DK036256, R01 DK036256-16S1] NR 6 TC 6 Z9 6 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0194-911X J9 HYPERTENSION JI Hypertension PD APR PY 2008 VL 51 IS 4 BP E22 EP E23 DI 10.1161/HYPERTENSIONAHA.107.109454 PG 2 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 276SA UT WOS:000254161300074 PM 18285610 ER PT J AU O'Shea, JJ Murray, PJ AF O'Shea, John J. Murray, Peter J. TI Cytokine signaling modules in inflammatory responses SO IMMUNITY LA English DT Review ID COLONY-STIMULATING FACTOR; T-CELL DIFFERENTIATION; HYPER-IGE SYNDROME; SOCS BOX; G-CSF; TH17 CELLS; ANTIINFLAMMATORY RESPONSE; NEGATIVE REGULATOR; IN-VIVO; INTERLEUKIN-10-DEFICIENT MICE AB Cytokine signaling via a restricted number of Jak-Stat pathways positively and negatively regulates all cell types involved in the initiation, propagation, and resolution of inflammation. Here, we focus on Jak-Stat signaling in three major cell types involved in inflammatory responses: T cells, neutrophils, and macrophages. We summarize how the Jak-Stat pathways in these cells are negatively regulated by the Suppressor of cytokine signaling (Socs) proteins. We emphasize that common Jak-Stat-Socs signaling modules can have diverse developmental, pro- and anti-inflammatory outcomes depending on the cytokine receptor activated and which genes are accessible at a given time in a cell's life. Because multiple components of Jak-Stat-Socs pathways are mutated or closely associated with human inflammatory diseases, and cytokine-based therapies are increasingly deployed to treat inflammation, understanding cytokine signaling will continue to advance our ability to manipulate chronic and acute inflammatory diseases. C1 [O'Shea, John J.] NIAMSD, Mol Immunol & Inflammat Branch, NIH, Bethesda, MD 20852 USA. [Murray, Peter J.] St Jude Childrens Hosp, Dept Infect Dis, Memphis, TN 38105 USA. [Murray, Peter J.] St Jude Childrens Hosp, Dept Immunol, Memphis, TN 38105 USA. RP O'Shea, JJ (reprint author), NIAMSD, Mol Immunol & Inflammat Branch, NIH, Bethesda, MD 20852 USA. EM osheajo@mail.nih.gov; peter.murray@stjude.org FU Intramural NIH HHS [Z01 AR041106-13]; NCI NIH HHS [P30 CA021765, P30 CA21765] NR 101 TC 312 Z9 328 U1 4 U2 54 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 1074-7613 J9 IMMUNITY JI Immunity PD APR PY 2008 VL 28 IS 4 BP 477 EP 487 DI 10.1016/j.immuni.2008.03.002 PG 11 WC Immunology SC Immunology GA 287TM UT WOS:000254939400006 PM 18400190 ER PT J AU Kulkarni, S Single, RM Martin, MP Rajalingam, R Badwe, R Joshi, N Carrington, M AF Kulkarni, S. Single, R. M. Martin, M. P. Rajalingam, R. Badwe, R. Joshi, N. Carrington, M. TI Comparison of the rapidly evolving KIR locus in Parsis and natives of India SO IMMUNOGENETICS LA English DT Article DE KIR; Genotyping; Western Indian Hindus; Parsis; India ID 3 ETHNIC-GROUPS; RECEPTOR GENES; HAPLOTYPE ANALYSIS; GENOMIC DIVERSITY; CELL; POPULATIONS; COEVOLUTION; SEQUENCES; FAMILIES; DISEASE AB The extreme variability at the Killer cell Immunoglobulin-like Receptor (KIR) locus along with that of the genes encoding their ligands, HLA class I, appears to modulate risk for viral, autoimmune, and malignant diseases, and reproductive failure. Differences in KIR gene and haplotype frequencies across world populations may reflect some combination of ancestral genotypes, locale-specific selection pressures, and genetic drift. We genotyped unrelated healthy Parsis and Maharashtrian Hindus, neighboring peoples from Western India. These two populations showed remarkable similarity in KIR gene frequencies despite their distinct ethnic background and the fairly recent migration of Parsis to Western India from Persia around 900 A.D. One clear exception is KIR3DS1, which is found at a significantly higher frequency in the Parsis than in the Maharashtrians, previously characterized North Indians, and most other world populations. The high KIR3DS1 frequency of Parsis corresponds with a low frequency of its putative HLA-B ligand group, an inverse correlation that has been observed previously across other world populations. Thus, KIR3DS1 frequency in Parsis may be a remnant of their distinct ancestral Persian origin. KIR gene frequencies and profiles of the Parsis and Maharashtrians were more similar to one another than they were to North Indians, suggesting a potential effect of local environmental factors on KIR evolution and/or some degree of admixture between Parsis and populations from Western India. Overall, these data support other studies indicating the rapid evolution of the KIR locus and the apparent dependency of this evolution on the loci encoding HLA class I ligands. C1 [Kulkarni, S.; Joshi, N.] ACTREC, Tata Mem Ctr, Canc Res Inst, Navi Mumbai 410208, Maharashtra, India. [Single, R. M.] Univ Vermont, Dept Math & Stat, Burlington, VT 05405 USA. [Martin, M. P.; Carrington, M.] SAIC Frederick Inc, NCI, Canc & Inflammat Program, Expt Immunol Lab, Frederick, MD 21702 USA. [Rajalingam, R.] Univ Calif Los Angeles, David Geffen Sch Med, UCLA Immunogenet Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA. [Badwe, R.] Tata Mem Hosp, Tata Mem Ctr, Bombay 400012, Maharashtra, India. RP Joshi, N (reprint author), ACTREC, Tata Mem Ctr, Canc Res Inst, Navi Mumbai 410208, Maharashtra, India. EM njoshi@actrec.gov.in; carringt@ncifcrf.gov FU NCI NIH HHS [N01-CO-12400] NR 35 TC 24 Z9 24 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0093-7711 J9 IMMUNOGENETICS JI Immunogenetics PD APR PY 2008 VL 60 IS 3-4 BP 121 EP 129 DI 10.1007/s00251-008-0279-1 PG 9 WC Genetics & Heredity; Immunology SC Genetics & Heredity; Immunology GA 290HG UT WOS:000255113300001 PM 18351333 ER PT J AU Wu, B Huang, CH Kato-Maeda, M Hopewell, PC Daley, CL Krensky, AM Clayberger, C AF Wu, Bo Huang, Chunhong Kato-Maeda, Midori Hopewell, Philip C. Daley, Charles L. Krensky, Alan M. Clayberger, Carol TI IL-24 modulates IFN-gamma expression in patients with tuberculosis SO IMMUNOLOGY LETTERS LA English DT Article DE Mycobacterium tuberculosis; cytokine; human ID MYCOBACTERIUM-TUBERCULOSIS; IMMUNITY; GENE; CELLS; INTERLEUKIN-24; INFECTION; RESPONSES; RECEPTOR; DISEASE; GROWTH AB IL-24 is a newly described member of the IL-10 family. We previously demonstrated that PBMC from TB patients exhibited low levels of IL-24 and IFN-gamma compared to subjects with latent tuberculosis infection (LTBI). In order to investigate the role of IL-24 in IFN-gamma expression in TB patients, we stimulated PBMC from individuals with LTBI or TB patients with the Mtb-specific antigen, early secretory antigenic target-6 (ESAT-6) and measured cytokine expression using quantitative real-time PCR (qPCR). Exogenous IL-24 increased IFN-gamma expression in PBMC obtained from TB patients while neutralization of IL-24 reduced IFN--y expression in PBMC from subjects with LTBI. Exogenous IL-24 enhanced IFN--y expression by increasing expression of IL-12 family cytokines, including IL-12 alpha, IL-12 beta, IL-23 alpha and IL-27, and by reducing FOXP3 expression in PBMC from TB patients. This is the first demonstration that IL-24 may play an important role in IFN--y expression following infection with Mtb. (C) 2007 Elsevier B.V. All rights reserved. C1 [Wu, Bo; Huang, Chunhong; Krensky, Alan M.; Clayberger, Carol] Stanford Univ, Sch Med, Dept Pediat, Stanford, CA 94305 USA. [Kato-Maeda, Midori; Hopewell, Philip C.] Univ Calif San Francisco, Francis J Curry Natl TB Ctr, Div Pulm & Crit Care Med, San Francisco, CA 94143 USA. [Daley, Charles L.] Natl Jewish Med & Res Ctr, Div Mycobacterial & Resp Infect, Denver, CO USA. RP Clayberger, C (reprint author), NCI, LCMB, NIH, Bldg 37,Room 4016,37 Convent Dr, Bethesda, MD 20892 USA. EM claybergerc@mail.nih.gov FU NIAID NIH HHS [R01 AI043348-07, 1 AI-75320] NR 24 TC 5 Z9 6 U1 1 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-2478 J9 IMMUNOL LETT JI Immunol. Lett. PD APR PY 2008 VL 117 IS 1 BP 57 EP 62 DI 10.1016/j.imlet.2007.11.018 PG 6 WC Immunology SC Immunology GA 291GV UT WOS:000255183400008 PM 18199488 ER PT J AU Lupo, P Chang, YC Kelsall, BL Farber, JM Pietrella, D Vecchiarelli, A Leon, F Kwon-Chung, KJ AF Lupo, P. Chang, Y. C. Kelsall, B. L. Farber, J. M. Pietrella, D. Vecchiarelli, A. Leon, F. Kwon-Chung, K. J. TI The presence of capsule in Cryptococcus neoformans influences the gene expression profile in dendritic cells during interaction with the fungus SO INFECTION AND IMMUNITY LA English DT Article ID NECROSIS-FACTOR-ALPHA; IN-VITRO; TRANSENDOTHELIAL MIGRATION; CANDIDA-ALBICANS; INTERFERON-GAMMA; IMMUNE-RESPONSE; TNF-ALPHA; T-CELLS; POLYSACCHARIDE; BINDING AB The aim of this investigation was to study the effect of polysaccharide capsule on the gene expression in dendritic cells (DC) during their interaction with Cryptococcus neoformans. To this end, we used an encapsulated virulent strain of C. neoformans and a cap59 gene-disrupted acapsular avirullent strain derived from the same genetic background. DC were exposed to encapsulated and acapsular C. neoformans strains for 4 It and 18 h, and their transcriptional profiles were analyzed using the Affymetrix mouse gene chip U74Av2. A large number of DC genes were up-regulated after treatment with the acapsular strain. In particular, we observed the up-regulation of the genes involved in DC maturation, such as cell surface receptors, cytokines, and chemokines (interleukin-12 [IL-12], IL-2, IL-1 alpha, IL-1 beta, IL-6, IL-10, tumor necrosis factor alpha, CCR7, CCL17, CCL22, CCU, CCU, CCL7, and CXCL10), membrane proteins, and the genes involved in antigen processing and presentation as well as cell cycle or apoptosis. The chemokine gene expression data were confirmed by real-time reverse transcription-PCR, while the expression of cytokine genes was correlated with their secretion. A completely different pattern of gene expression was observed for DC treated with an encapsulated strain of C. neoformans. In particular, no significant induction was observed in the expression of the genes mentioned above. Moreover, a number of genes, such as those coding for chemokines, were down-regulated. These results suggest that the polysaccharide capsule shrouding the cell wall of C. neoformans plays a fundamental role in inducing DC response, highlighting the molecular basis of the true nature of immune silencing exerted by capsular material. C1 [Lupo, P.; Chang, Y. C.; Kwon-Chung, K. J.] NIAID, Clin Invest Lab, Bethesda, MD 20892 USA. [Kelsall, B. L.; Farber, J. M.; Leon, F.] NIAID, Lab Mol Immunol, Bethesda, MD 20892 USA. [Lupo, P.; Pietrella, D.] Univ Perugia, Dept Expt Med & Biochem Sci, Microbiol Sect, I-06123 Perugia, Italy. RP Kwon-Chung, KJ (reprint author), NIAID, LCID, NIH, Bldg 10,Rm 11N234, Bethesda, MD 20892 USA. EM June-Kwon-Chung@nih.gov OI Vecchiarelli, Anna/0000-0002-3185-6720; Leon, Francisco/0000-0002-5064-2381 FU Intramural NIH HHS NR 49 TC 16 Z9 16 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD APR PY 2008 VL 76 IS 4 BP 1581 EP 1589 DI 10.1128/IAI.01184-07 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 284SI UT WOS:000254725700026 PM 18250173 ER PT J AU Whiston, EA Sugi, N Kamradt, MC Sack, C Heimer, SR Engelbert, M Wawrousek, EF Gilmore, MS Ksander, BR Gregory, MS AF Whiston, Emily A. Sugi, Norito Kamradt, Merideth C. Sack, Coralynn Heimer, Susan R. Engelbert, Michael Wawrousek, Eric F. Gilmore, Michael S. Ksander, Bruce R. Gregory, Meredith S. TI alpha B-crystallin protects retinal tissue during Staphylococcus aureus-induced endophthalmitis SO INFECTION AND IMMUNITY LA English DT Article ID HEAT-SHOCK-PROTEIN; BACTERIAL ENDOPHTHALMITIS; EXTRACELLULAR PROTEASES; MYOGENIC DIFFERENTIATION; PIGMENT EPITHELIUM; INDUCED APOPTOSIS; IMMUNE PRIVILEGE; ACTIVATION; EXPRESSION; CELLS AB Bacterial infections of the eye highlight a dilemma that is central to all immune-privileged sites. On the one hand, immune privilege limits inflammation to prevent bystander destruction of normal tissue and loss of vision. On the other hand, bacterial infections require a robust inflammatory response for rapid clearance of the pathogen. We demonstrate that the retina handles this dilemma, in part, by activation of a protective heat shock protein. During Staphylococcus aureus-induced endophthalmitis, the small heat shock protein alpha B-crystallin is upregulated in the retina and prevents apoptosis during immune clearance of the bacteria. In the absence of alpha B-crystallin, mice display increased retinal apoptosis and retinal damage. We found that S. aureus produces a protease capable of cleaving alpha B-crystallin to a form that coincides with increased retinal apoptosis and tissue destruction. We conclude that alpha B-crystallin is important in protecting sensitive retinal tissue during destructive inflammation that occurs during bacterial endophthalmitis. C1 [Whiston, Emily A.; Sugi, Norito; Sack, Coralynn; Heimer, Susan R.; Gilmore, Michael S.; Ksander, Bruce R.; Gregory, Meredith S.] Harvard Univ, Sch Med, Schepens Eye Res Inst, Dept Ophthalmol, Boston, MA 02114 USA. [Kamradt, Merideth C.] Bridgewater State Coll, Sch Arts & Sci, Bridgewater, MA 02325 USA. [Engelbert, Michael] Columbia Univ Coll Phys & Surg, Edward S Harkness Eye Inst, New York, NY 10032 USA. [Wawrousek, Eric F.] NEI, Natl Inst Hlth, Bethesda, MD 20892 USA. RP Gregory, MS (reprint author), Harvard Univ, Sch Med, Schepens Eye Res Inst, Dept Ophthalmol, 20 Staniford St, Boston, MA 02114 USA. EM meredith.gregory@schepens.harvard.edu FU NEI NIH HHS [R01 EY008289, R01-EY016145, R01 EY016145, EY08289] NR 44 TC 46 Z9 50 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD APR PY 2008 VL 76 IS 4 BP 1781 EP 1790 DI 10.1128/IAI.01285-07 PG 10 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 284SI UT WOS:000254725700048 PM 18227158 ER PT J AU Avril, M Kulasekara, BR Gose, SO Rowe, C Dahlback, M Duffy, PE Fried, M Salanti, A Misher, L Narum, DL Smith, JD AF Avril, Marion Kulasekara, Bridget R. Gose, Severin O. Rowe, Chris Dahlback, Madeleine Duffy, Patrick E. Fried, Michal Salanti, Ali Misher, Lynda Narum, David L. Smith, Joseph D. TI Evidence for globally shared, cross-reacting polymorphic epitopes in the pregnancy-associated malaria vaccine candidate VAR2CSA SO INFECTION AND IMMUNITY LA English DT Article ID CHONDROITIN-SULFATE-A; FALCIPARUM-INFECTED ERYTHROCYTES; VARIANT SURFACE-ANTIGENS; CSA-BINDING PARASITES; PLASMODIUM-FALCIPARUM; VAR GENES; PLACENTAL MALARIA; PICHIA-PASTORIS; IMMUNOGLOBULIN-G; STRUCTURAL BASIS AB Pregnancy-associated malaria (PAM) is characterized by the placental sequestration of Plasmodium falciparum-infected erythrocytes (IEs) with the ability to bind to chondroitin sulfate A (CSA). VAR2CSA is a leading candidate for a pregnancy malaria vaccine, but its large size (similar to 350 kDa) and extensive polymorphism may pose a challenge to vaccine development. In this study, rabbits were immunized with individual VAR2CSA Duffy binding-like (DBL) domains expressed in Pichia pastoris or var2csa plasmid DNA and sera were screened on different CSA-binding parasite lines. Rabbit antibodies to three recombinant proteins (DBL1, DBL3, and DBL6) and four plasmid DNAs (DBL1, DBL3, DBL5, and DBL6) reacted with homologous FCR3-CSA IEs. By comparison, antibodies to the DBL4 domain were unable to react with native VAR2CSA protein unless it was first partially proteolyzed with trypsin or chymotrypsin. To investigate the antigenic relationship of geographically diverse CSA-binding isolates, rabbit immune sera were screened on four heterologous CSA-binding lines from different continental origins. Antibodies did not target conserved epitopes exposed in all VAR2CSA alleles; however, antisera to several DBL domains cross-reacted on parasite isolates that had polymorphic loops in common with the homologous immunogen. This study demonstrates that VAR2CSA contains common polymorphic epitopes that are shared between geographically diverse CSA-binding lines. C1 [Avril, Marion; Kulasekara, Bridget R.; Gose, Severin O.; Duffy, Patrick E.; Fried, Michal; Misher, Lynda; Smith, Joseph D.] Seattle Biomed Res Inst, Seattle, WA 98109 USA. [Rowe, Chris; Narum, David L.] NIAID, Malaria Vaccine Dev Branch, Natl Inst Hlth, Rockville, MD 20852 USA. [Dahlback, Madeleine; Salanti, Ali] Univ Copenhagen, Ctr Med Parasitol, Copenhagen, Denmark. [Smith, Joseph D.] Univ Washington, Dept Pathobiol, Seattle, WA 98195 USA. RP Smith, JD (reprint author), Seattle Biomed Res Inst, 307 Westlake Ave N,Suite 500, Seattle, WA 98109 USA. EM joseph.smith@sbri.org OI Gose, Severin/0000-0002-8044-9347 NR 46 TC 31 Z9 31 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD APR PY 2008 VL 76 IS 4 BP 1791 EP 1800 DI 10.1128/IAI.01470-07 PG 10 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 284SI UT WOS:000254725700049 PM 18250177 ER PT J AU Henderson, DK AF Henderson, David K. TI Patient-to-patient transmission of bloodborne pathogens in health care: The price and perils of progress? SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Editorial Material ID HEPATITIS-C VIRUS; NOSOCOMIAL TRANSMISSION; HIV-TRANSMISSION; INFECTION; OUTBREAK; WARD; HCV; BRONCHOSCOPES; VIALS C1 [Henderson, David K.] NIH, Ctr Clin, Bethesda, MD 20892 USA. RP Henderson, DK (reprint author), Bldg 10,Room 6-1480,10 Ctr Dr, Bethesda, MD 20892 USA. EM dkh@nih.gov NR 21 TC 2 Z9 2 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0899-823X J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD APR PY 2008 VL 29 IS 4 BP 294 EP 296 DI 10.1086/587440 PG 3 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 271VP UT WOS:000253817100002 PM 18462139 ER PT J AU Steinert, AF Noth, U Tuan, RS AF Steinert, Andre F. Noeth, Ulrich Tuan, Rocky S. TI Concepts in gene therapy for cartilage repair SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED LA English DT Review DE articular cartilage; gene therapy; chondrocyte; mesenchymal stem cell; growth factor ID MESENCHYMAL STEM-CELLS; GROWTH-FACTOR-I; COLLAGEN-INDUCED ARTHRITIS; HUMAN ARTICULAR CHONDROCYTES; RECEPTOR-ANTAGONIST PROTEIN; MARROW STROMAL CELLS; BONE MORPHOGENETIC PROTEIN-2; OLIGOMERIC MATRIX PROTEIN; NITRIC-OXIDE SYNTHASE; EX-VIVO MODEL AB Once articular cartilage is injured, it has a very limited capacity for self repair. Although current surgical therapeutic procedures for cartilage repair are clinically useful, they cannot restore a normal articular surface. Current research offers a growing number of bioactive reagents, including proteins and nucleic acids, that may be used to augment various aspects of the repair process. As these agents are difficult to administer effectively, gene-transfer approaches are being developed to provide their sustained synthesis at sites of repair. To augment regeneration of articular cartilage, therapeutic genes can be delivered to the synovium or directly to the cartilage lesion. Gene delivery to the cells of the synovial lining is generally considered more suitable for chondroprotective approaches, based on the expression of anti -inflammatory mediators. Gene transfer targeted at cartilage defects can be achieved by either direct vector administration to cells located at or surrounding the defects, or by transplantation of genetically modified chondrogenic cells into the defect. Several studies have shown that exogenous cDNAs encoding growth factors can be delivered locally to sites of cartilage damage, where they are expressed at therapeutically relevant levels. Furthermore, data is beginning to emerge indicating that efficient delivery and expression of these genes is capable of influencing a repair response toward the synthesis of a more hyaline cartilage repair tissue in vivo. This review presents the current status of gene therapy for cartilage heating and highlights some of the remaining challenges. C1 [Tuan, Rocky S.] Natl Inst Arthrit & Musculoskeletal & Skin Dis, NIH, Cartilage Biol & Orthopaed Branch, Bethesda, MD 20892 USA. [Steinert, Andre F.; Noeth, Ulrich] Univ Wurzburg, Orthopaed Ctr Musuloskeletal Res, Wurzburg, Germany. RP Tuan, RS (reprint author), Natl Inst Arthrit & Musculoskeletal & Skin Dis, NIH, Cartilage Biol & Orthopaed Branch, Bldg 50,Room 1523,50 South Dr MSC 8022, Bethesda, MD 20892 USA. EM tuanr@mail.nih.gov RI Steinert, Prof. Dr. , Andre/P-4559-2015 OI Steinert, Prof. Dr. , Andre/0000-0002-4397-8434 FU Intramural NIH HHS [Z01 AR041131-06]; NIAMS NIH HHS [Z01 AR 41131, Z01 AR041131] NR 198 TC 60 Z9 70 U1 1 U2 12 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0020-1383 J9 INJURY JI Injury-Int. J. Care Inj. PD APR PY 2008 VL 39 SU 1 BP S97 EP S113 DI 10.1016/j.injury.2008.01.034 PG 17 WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery GA 293UW UT WOS:000255361900013 PM 18313477 ER PT J AU Newbold, RR Padilla-Banks, E Jefferson, WN Heindel, JJ AF Newbold, Retha R. Padilla-Banks, Elizabeth Jefferson, Wendy N. Heindel, Jerrold J. TI Effects of endocrine disruptors on obesity SO INTERNATIONAL JOURNAL OF ANDROLOGY LA English DT Article; Proceedings Paper CT 4th Copenhagen Workshop on Endocrine Disrupters CY MAY 28-31, 2007 CL Copenhagen Univ Hosp, Copenhagen, DENMARK HO Copenhagen Univ Hosp DE adipocytes; environmental estrogens; leptin; metabolic disease; obesogens; xenoestrogens ID BODY-FAT DISTRIBUTION; BISPHENOL-A; DEVELOPMENTAL EXPOSURE; ENVIRONMENTAL ESTROGENS; FETAL ORIGINS; 3T3-L1 CELLS; RISK-FACTORS; DIETHYLSTILBESTROL; EPIDEMIC; ADIPOCYTES AB Environmental chemicals with hormone-like activity can disrupt the programming of endocrine signalling pathways that are established during perinatal life and result in adverse consequences that may not be apparent until much later in life. Increasing evidence implicates developmental exposure to environmental hormone mimics with a growing list of adverse health consequences in both males and females. Most recently, obesity has been proposed to be yet another adverse health effect of exposure to endocrine disrupting chemicals (EDCs) during critical stages of development. Obesity is quickly becoming a significant human health crisis because it is reaching epidemic proportions worldwide, and is associated with chronic illnesses such as diabetes and cardiovascular disease. In this review, we summarize the literature reporting an association of EDCs and the development of obesity, and further describe an animal model of exposure to diethylstilbestrol that has proven useful in studying mechanisms involved in abnormal programming of various oestrogen target tissues during differentiation. Together, these data suggest new targets (i.e. adipocyte differentiation and mechanisms involved in weight homeostasis) of abnormal programming by EDCs, and provide evidence that support the scientific term 'the developmental origins of adult disease'. The emerging idea of an association of EDCs and obesity expands the focus on obesity from intervention and treatment to include prevention and avoidance of these chemical modifiers. C1 [Newbold, Retha R.; Padilla-Banks, Elizabeth; Jefferson, Wendy N.] NIEHS, Dev Endocrinol & Endocrine Disruptor Sect, Mol Toxicol Lab, Div Intramural Res, Res Triangle Pk, NC 27709 USA. [Heindel, Jerrold J.] NIEHS, Div Extramural Res, Res Triangle Pk, NC 27709 USA. RP Newbold, RR (reprint author), NIEHS, Dev Endocrinol & Endocrine Disruptor Sect, Mol Toxicol Lab, Div Intramural Res, Mail Drop E4-02, Res Triangle Pk, NC 27709 USA. EM newbold1@niehs.nih.gov FU Intramural NIH HHS NR 41 TC 169 Z9 173 U1 3 U2 36 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0105-6263 J9 INT J ANDROL JI Int. J. Androl. PD APR PY 2008 VL 31 IS 2 BP 201 EP 207 DI 10.1111/j.1365-2605.2007.00858.x PG 7 WC Andrology SC Endocrinology & Metabolism GA 270GW UT WOS:000253710200030 PM 18315718 ER PT J AU McLean, L Soto, U Agama, K Francis, J Jimenez, R Pommier, Y Sowers, L Brantley, E AF McLean, Lancelot Soto, Ubaldo Agama, Keli Francis, Jawad Jimenez, Randi Pommier, Yves Sowers, Lawrence Brantley, Eileen TI Aminoflavone induces oxidative DNA damage and reactive oxidative species-mediated apoptosis in breast cancer cells SO INTERNATIONAL JOURNAL OF CANCER LA English DT Article; Proceedings Paper CT 97th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 01-05, 2006 CL Washington, DC SP Amer Assoc Canc Res DE DNA damage; oxidative stress; apoptosis; breast cancer; aminoflavone ID PROTEIN CROSS-LINKS; P21(WAF1/CIP1) EXPRESSION; ANTICANCER PROPERTIES; ANTITUMOR AGENT; S-PHASE; P53; ACTIVATION; NSC-686288; INDUCTION; LINES AB Aminoflavone (5-amino-2-(4-amino-3-fluorophenyl)-6,8-difluoro7-methylehromen-4-one; AF; NSC 686288), a novel anticancer candidate agent, is undergoing clinical evaluation. AF induces DNA-protein cross-links (DPCs), gamma-H2AX phosphorylation, aryl hydrocarbon receptor (AhR) signaling, apoptosis and its own metabolism via cytochrome P4501A1 and 1A2 (CYP1A1/1A2) activation in sensitive estrogen receptor positive (ER+) MCF7 breast cancer cells. Estrogen receptor negative (ER-) breast cancer is typically more aggressive with a poorer prognosis. In this investigation, we evaluated the ability of AF to induce reactive oxygen species (ROS) formation, oxidative DNA damage and apoptosis in ER- MDA-MB-468 breast cancer cells. The antioxidant, N-acetyl-L-Cysteine (NAC), attenuated the cytotoxic effects of AF in MDA-MB-468 cells; an effect is also observed in ER+ T47D breast cancer cells. Nonmalignant MCF10A breast epithelial cells were resistant to the cytotoxic effects of AF. AF increased intracellular ROS, an effect blocked by NAC and the CYP1A1/1A2 inhibitor, a-Naphthoflavone (alpha-NF). AF induced oxidative DNA damage as evidenced by increased 8-oxo-7,8-dihydroguanine (8-oxodG) levels and DPC formation in these cells. AF caused S-phase arrest corresponding to an increase in p21((waf1/cip1)) protein expression. AF induced caspase 3, 8 and 9 activation, caspase-dependent apoptotic body formation and poly [ADP-ribose] polymerase (PARP) cleavage. Pretreatment with the pan-caspase inhibitor, benzyloxy-carbonyl-Val-Ala-DL-Asp(OMe)-fluoromethylketone inhibited apoptosis and partially inhibited ROS formation and oxidative DNA damage. Pretreatment with NAC attenuated AF-induced apoptotic body formation and caspase 3 activation. These studies suggest AF inhibits the growth of breast cancer cells in part, by inducing ROS production, oxidative DNA damage and apoptosis and has the potential to treat hormone-independent breast cancer. (c) 2007 Wiley-Liss, Inc. C1 [Jimenez, Randi; Sowers, Lawrence; Brantley, Eileen] Loma Linda Univ, Sch Med, Dept Physiol & Pharmacol, Loma Linda, CA 92350 USA. [McLean, Lancelot; Soto, Ubaldo; Francis, Jawad; Sowers, Lawrence] Loma Linda Univ, Sch Med, Dept Biochem & Microbiol, Loma Linda, CA 92350 USA. [Agama, Keli; Pommier, Yves] NCI, Mol Pharmacol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. [Jimenez, Randi; Brantley, Eileen] Loma Linda Univ, Sch Med, Ctr Hlth Dispar & Mol Med, Loma Linda, CA 92350 USA. [Brantley, Eileen] Loma Linda Univ, Sch Pharm, Dept Pharmaceut Sci, Loma Linda, CA 92350 USA. RP Brantley, E (reprint author), Loma Linda Univ, Sch Med, Dept Physiol & Pharmacol, Alumni Hall Room 119, Loma Linda, CA 92350 USA. EM ebrantley@llu.edu FU Intramural NIH HHS; NIGMS NIH HHS [R25 GM060507-02, R25 GM060507-01A1, 5R01GM41336, R01 GM041336, R01 GM041336-16, R25 GM060507]; NIMHD NIH HHS [P20 MD001632, P20 MD006988, 5P20 MD001632, P20 MD001632-01] NR 45 TC 30 Z9 30 U1 0 U2 4 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0020-7136 J9 INT J CANCER JI Int. J. Cancer PD APR 1 PY 2008 VL 122 IS 7 BP 1665 EP 1674 DI 10.1002/ijc.23244 PG 10 WC Oncology SC Oncology GA 266MW UT WOS:000253441100027 PM 18059023 ER PT J AU Manolio, TA AF Manolio, Teri A. TI Biorepositories - at the bleeding edge SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY LA English DT Editorial Material ID GENETICS; BIOBANK C1 [Manolio, Teri A.] NHGRI, NIH, Bethesda, MD 20892 USA. RP Manolio, TA (reprint author), NHGRI, NIH, Bethesda, MD 20892 USA. EM manoliot@nhgri.nih.gov NR 20 TC 8 Z9 8 U1 1 U2 2 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0300-5771 J9 INT J EPIDEMIOL JI Int. J. Epidemiol. PD APR PY 2008 VL 37 IS 2 BP 231 EP 233 DI 10.1093/ije/dym282 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 284NP UT WOS:000254713400003 PM 18381397 ER PT J AU Geller, SE Goudar, SS Adams, MG Naik, VA Patel, A Bellad, MB Patted, SS Edlavitch, SA Moss, N Kodkany, BS Derman, RJ AF Geller, Stacie E. Goudar, Shivaprasad S. Adams, Marci G. Naik, Vijaya A. Patel, Ashlesha Bellad, MrUtyunjaya B. Patted, Shobhana S. Edlavitch, Stanley A. Moss, Nancy Kodkany, Bhalchandra S. Derman, Richard J. TI Factors associated with acute postpartum hemorrhage in low-risk women delivering in rural India SO INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS LA English DT Article DE India; maternal mortality; postpartum hemorrhage ID RANDOMIZED CONTROLLED-TRIAL; ORAL MISOPROSTOL; 3RD STAGE; LABOR; MANAGEMENT; 3RD-STAGE; SETTINGS AB Objective: Postpartum hemorrhage (PPH), a major cause of maternal mortality and morbidity in low-income countries, can occur unpredictably. This study examined the sociodemographic, clinical, and perinatal. characteristics of low-risk women who experienced PPH. Methods: This analysis was conducted using data on 1620 women from a randomized trial testing oral misoprostol. for prevention of PPH in rural India. Results: Of the women, 9.2% experienced PPH. No maternal or sociodemographic factors and few perinatal factors differed between women with PPH and those without, other than treatment with misoprostol. Having fewer than 4 prenatal visits and Lack of iron supplementation increased the risk for PPH (P<0.001 and P=0.037, respectively). Several factors unknown until the second stage of tabor (perineal tear and birth weight) were also associated (P=0.003). Conclusions: Among women at Low risk for PPH, there were few factors associated with further risk. Given that PPH can occur without warning, rural communities should consider ways to increase both primary prevention (iron supplementation, AMTSL) and secondary prevention of PPH (availability of obstetric first aid, availability of transport, and availability of emergency obstetric care). (C) 2008 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved. C1 [Geller, Stacie E.; Adams, Marci G.] Univ Illinois, Coll Med, Chicago, IL 60607 USA. [Goudar, Shivaprasad S.; Naik, Vijaya A.; Bellad, MrUtyunjaya B.; Patted, Shobhana S.; Kodkany, Bhalchandra S.] Jawaharlal Nehru Univ, Coll Med, Belgaum, Karnataka, India. [Patel, Ashlesha] John H Stroger Jr Hosp Cook Cty, Chicago, IL USA. [Edlavitch, Stanley A.; Derman, Richard J.] Univ Missouri, City Sch Med, Kansas City, MO 64110 USA. [Moss, Nancy] Natl Inst Hlth, Bethesda, MD USA. RP Geller, SE (reprint author), Univ Illinois, Coll Med, Chicago, IL 60607 USA. EM SGetter@uic.edu OI GOUDAR, SHIVAPRASAD/0000-0002-8680-7053 FU NICHD NIH HHS [U01 HD042372-01, 1 U01 HD42372-01, U01 HD042372] NR 25 TC 16 Z9 16 U1 0 U2 6 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0020-7292 J9 INT J GYNECOL OBSTET JI Int. J. Gynecol. Obstet. PD APR PY 2008 VL 101 IS 1 BP 94 EP 99 DI 10.1016/j.ijgo.2007.08.025 PG 6 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 290VE UT WOS:000255150000025 PM 18291401 ER PT J AU Soares-Souza, GB Tarazona-Santos, E Chanock, SJ AF Soares-Souza, G. B. Tarazona-Santos, E. Chanock, S. J. TI Characterization of a candidate locus for malaria susceptibility in human populations: a (TA)(n) microsatellite in the promoter region of the CYBB gene, the gp91(phox) subunit of the NADPH oxidase SO INTERNATIONAL JOURNAL OF IMMUNOGENETICS LA English DT Article ID CHRONIC GRANULOMATOUS-DISEASE; EXPRESSION; REPRESSES; COMPLEX AB We have analysed the linkage disequilibrium pattern between the promoter TA microsatellite and Single Nucleotide Polymorphism (SNP) haplotypes for the CYBB gene. None of the CYBB SNPs serve as good surrogates for the microsatellite alleles, previously associated with mild malaria. Thus, the candidate (TA)(n) microsatellite should be directly tested in genetic epidemiology studies. C1 [Soares-Souza, G. B.; Tarazona-Santos, E.] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Biol Geral, BR-31270910 Belo Horizonte, MG, Brazil. [Soares-Souza, G. B.] Fundacao Hemominas, Serv Pesquisa, Minas Gerais, Brazil. [Tarazona-Santos, E.; Chanock, S. J.] NIH, Sect Genom Variat, Pediat Oncol Branch, Natl Canc Inst, Gaithersburg, MD USA. RP Tarazona-Santos, E (reprint author), Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Biol Geral, 6627 Pampulha,Caixa Postal 486, BR-31270910 Belo Horizonte, MG, Brazil. EM edutars@icb.ufmg.br FU Intramural NIH HHS NR 13 TC 1 Z9 1 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1744-3121 J9 INT J IMMUNOGENET JI Int. J. Immunogenet. PD APR PY 2008 VL 35 IS 2 BP 107 EP 109 DI 10.1111/j.1744-313X.2008.00750.x PG 3 WC Genetics & Heredity; Immunology SC Genetics & Heredity; Immunology GA 270ZJ UT WOS:000253758400004 PM 18321306 ER PT J AU Hall, KD Hallgreen, CE AF Hall, K. D. Hallgreen, C. E. TI Increasing weight loss attenuates the preferential loss of visceral compared with subcutaneous fat: a predicted result of an allometric model SO INTERNATIONAL JOURNAL OF OBESITY LA English DT Letter C1 [Hall, K. D.] NIDDK, Natl Inst Hlth, Lab Biol Modeling, Bethesda, MD 20892 USA. [Hallgreen, C. E.] Tech Univ Denmark, Dept Phys, Kongens Lyngby, Denmark. RP Hall, KD (reprint author), NIDDK, Natl Inst Hlth, Lab Biol Modeling, Bethesda, MD 20892 USA. EM kevinh@niddk.nih.gov RI Hall, Kevin/F-2383-2010 FU Intramural NIH HHS [Z01 DK013036-01] NR 3 TC 11 Z9 12 U1 0 U2 4 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0307-0565 J9 INT J OBESITY JI Int. J. Obes. PD APR PY 2008 VL 32 IS 4 BP 722 EP 722 DI 10.1038/ijo.2008.14 PG 1 WC Endocrinology & Metabolism; Nutrition & Dietetics SC Endocrinology & Metabolism; Nutrition & Dietetics GA 287JY UT WOS:000254914600019 PM 18301391 ER PT J AU Riddle, MA Walekup, JT Vitiello, B AF Riddle, Mark A. Walekup, John T. Vitiello, Benedetto TI Introduction: Issues and viewpoints in pediatric psychopharmacology SO INTERNATIONAL REVIEW OF PSYCHIATRY LA English DT Editorial Material C1 [Riddle, Mark A.; Walekup, John T.] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Div Child & Adolescent Psychiat, Baltimore, MD 21205 USA. [Vitiello, Benedetto] NIMH, Baltimore, MD USA. RP Riddle, MA (reprint author), Johns Hopkins Univ Hosp, CMSC 346,600 N Wolfe St, Baltimore, MD 21287 USA. EM mriddle1@jhmi.edu NR 2 TC 1 Z9 1 U1 1 U2 1 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0954-0261 J9 INT REV PSYCHIATR JI Int. Rev. Psych. PD APR PY 2008 VL 20 IS 2 BP 119 EP 120 DI 10.1080/09540260801887694 PG 2 WC Psychiatry SC Psychiatry GA 297DZ UT WOS:000255598600001 PM 18386200 ER PT J AU Vitiello, B AF Vitiello, Benedetto TI An international perspective on pediatric psychopharmacology SO INTERNATIONAL REVIEW OF PSYCHIATRY LA English DT Article ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; STIMULANT MEDICATION USE; PSYCHIATRIC-DISORDERS; BIPOLAR DISORDER; MENTAL-DISORDERS; NATIONAL TRENDS; US CHILDREN; PREVALENCE; ADHD; ADOLESCENTS AB The use of pharmacotherapy for children and adolescents with mental disorders varies widely across countries. More than 80% of the world use of stimulant medications occurs in the USA. The use of antidepressants and antipsychotics is many times greater in the USA than in other countries. Factors likely to influence the pediatric use of psychotropic medications are here examined and discussed. Variability in use reflects differences in diagnostic systems, clinical practice guidelines, drug regulation, health services organization, availability and allocation of financial resources, and cultural attitudes towards childhood behavioral and emotional disturbances. Cultural context seems to exert a greater influence on the identification and management of psychiatric disorders than on other areas of medicine. It is currently unknown if the heterogeneity in treatment approaches results in differential clinical outcomes and prognosis. A better understanding of the factors underlying international variability may help clarify the process of diagnosis and treatment selection in child and adolescent psychiatry. C1 NIMH, Bethesda, MD 20892 USA. RP Vitiello, B (reprint author), NIMH, Room 7147,6001 Execut Blvd, Bethesda, MD 20892 USA. EM bvitiell@mail.nih.gov NR 40 TC 22 Z9 22 U1 2 U2 7 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0954-0261 J9 INT REV PSYCHIATR JI Int. Rev. Psych. PD APR PY 2008 VL 20 IS 2 BP 121 EP 126 DI 10.1080/09540260801887710 PG 6 WC Psychiatry SC Psychiatry GA 297DZ UT WOS:000255598600002 PM 18386201 ER PT J AU Knox, JJ Chen, XE Feld, R Nematollahi, M Cheiken, R Pond, G Zwiebel, JA Gill, S Moore, M AF Knox, J. J. Chen, X. E. Feld, R. Nematollahi, M. Cheiken, R. Pond, G. Zwiebel, J. A. Gill, S. Moore, M. TI A phase I-II study of oblimersen sodium (G3139, Genasense) in combination with doxorubicin in advanced hepatocellular carcinoma (NCI # 5798) SO INVESTIGATIONAL NEW DRUGS LA English DT Article; Proceedings Paper CT Gastrointestinal Cancers Symposium CY JAN, 2004 CL San Francisco, CA SP ASCO DE phase I-II; hepatocellular carcinoma; G3139; antisense oligonucleotide; Bcl-2; hepatoma ID CELL-LINE; LIVER; APOPTOSIS; QGY-7703; DISEASES; PATHWAY; TRIAL C1 [Knox, J. J.] Univ Toronto, Princess Margaret Hosp, Univ Hlth Network, Toronto, ON M5G 2M9, Canada. [Knox, J. J.; Chen, X. E.; Feld, R.; Nematollahi, M.; Cheiken, R.; Pond, G.; Moore, M.] Princess Margaret Hosp Phase Consortium 2, Toronto, ON, Canada. [Zwiebel, J. A.] Natl Canc Inst, Canc Therapy Evaluat Program, Bethesda, MD USA. [Gill, S.] British Columbia Canc Agcy, Vancouver, BC V5Z 4E6, Canada. RP Knox, JJ (reprint author), Univ Toronto, Princess Margaret Hosp, Univ Hlth Network, 610 Univ Ave, Toronto, ON M5G 2M9, Canada. EM jennifer.knox@uhn.on.ca NR 12 TC 8 Z9 9 U1 0 U2 4 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0167-6997 J9 INVEST NEW DRUG JI Invest. New Drugs PD APR PY 2008 VL 26 IS 2 BP 193 EP 194 DI 10.1007/s10637-007-9104-1 PG 2 WC Oncology; Pharmacology & Pharmacy SC Oncology; Pharmacology & Pharmacy GA 271CB UT WOS:000253765400011 PM 18060598 ER PT J AU Shan, X Tian, J Ying, HS Walker, MF Guyton, D Quaia, C Optican, LM Tamargo, RJ Zee, DS AF Shan, Xiaoyan Tian, Jing Ying, Howard S. Walker, Mark F. Guyton, David Quaia, Christian Optican, Lance M. Tamargo, Rafael J. Zee, David S. TI The effect of acute superior oblique palsy on torsional optokinetic nystagmus in monkeys SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Article ID SACCADES AB PURPOSE. To investigate the effects of acquired superior oblique palsy (SOP) and corrective strabismus surgery on torsional optokinetic nystagmus (tOKN) in monkeys. METHODS. The trochlear nerve was severed intracranially in two rhesus monkeys (M1 and M2). For each monkey, more than 4 months after the SOP, the ipsilateral inferior oblique muscle was denervated and extirpated. For M2, 4 months later, the contralateral inferior rectus muscle was recessed by 2 mm. tOKN was elicited during monocular viewing of a rotating stimulus that was rear projected onto a screen 43.5 cm in front of the animal. Angular rotation of the stimulus about the center was 40 deg/s clockwise or counterclockwise. RESULTS. The main findings after trochlear nerve sectioning were (1) the amplitude and peak velocity of torsional quick and slow phases of the paretic eye was less than that in the normal eye for both intorsion and extorsion, and (2) the vertical motion of the paretic eye increased during both torsional slow and quick phases. After corrective inferior oblique surgery, both of these effects were even greater. CONCLUSIONS. Acquired SOP and corrective inferior oblique weakening surgery create characteristic patterns of change in tOKN that reflect alterations in the dynamic properties of the extraocular muscles involved in eye torsion. tOKN also provides information complementary to that provided by the traditional Bielschowsky head-tilt test and potentially can help distinguish among different causes of vertical ocular misalignment. C1 [Shan, Xiaoyan; Tian, Jing; Walker, Mark F.; Zee, David S.] Johns Hopkins Univ Hosp, Dept Neurol, Sch Med, Baltimore, MD 21287 USA. [Ying, Howard S.; Walker, Mark F.; Guyton, David; Zee, David S.] Johns Hopkins Univ Hosp, Dept Ophthalmol, Sch Med, Baltimore, MD 21287 USA. [Tamargo, Rafael J.] Johns Hopkins Univ Hosp, Dept Neurosurg, Sch Med, Baltimore, MD 21287 USA. [Quaia, Christian; Optican, Lance M.] NEI, Sensorimotor Res Lab, NIH, Bethesda, MD 20892 USA. RP Zee, DS (reprint author), Johns Hopkins Univ Hosp, Dept Neurol, Sch Med, Path 2-210,600 N Wolfe St, Baltimore, MD 21287 USA. EM dzee@jhmi.edu FU NEI NIH HHS [K23EY00400, K12 EY015025, K12EY015025, R01 EY001849, R01 EY001849-31, R01 EY001849-32, R01-EY001849] NR 9 TC 4 Z9 4 U1 0 U2 0 PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC PI ROCKVILLE PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD APR PY 2008 VL 49 IS 4 BP 1421 EP 1428 DI 10.1167/iovs.07-0989 PG 8 WC Ophthalmology SC Ophthalmology GA 282ON UT WOS:000254577200021 PM 18385059 ER PT J AU Alur, RP Cox, TA Crawford, MA Gong, XH Brooks, BP AF Alur, Ramakrishna P. Cox, Terry A. Crawford, Mary Alice Gong, Xiaohua Brooks, Brian P. TI Optic nerve axon number in mouse is regulated by PAX2 SO JOURNAL OF AAPOS LA English DT Article; Proceedings Paper CT 33rd Annual Meeting of the American-Association-for-Pediatric-Ophthalmology-and-Strabismus CY APR 11-15, 2007 CL Seattle, WA SP Amer Assoc Pediat Ophthalmol & Strabismus ID RENAL-COLOBOMA SYNDROME; VESICOURETERAL REFLUX; MISSENSE MUTATION; GENE; EXPRESSION; DEFECTS; TYROSINASE; ANOMALIES; KIDNEY; TISSUE AB BACKGROUND Papillorenal syndrome is an autosomal-dominant disease caused by mutations in the PAX2 transcription factor gene. Patients often exhibit congenital excavation of the optic nerve and a spectrum of congenital kidney abnormalities. Using a novel mouse model of this syndrome (C57BL/6J PAX2(A220G/+)), we investigated the effect of PAX2 haploinsuffciency on optic nerve axon number. Because PAX2 expression and retinal pigment epithelium pigmentation have a mutually exclusive relationship during development and because tyrosinase (Tyr) has been shown to modify the penetrance of other ocular development genes, we also investigated whether tyrosinase modified the mutant PAX2 phenotype. METHODS C57BL/6J PAX2(A220G/+) Tyr(+/+) mice were crossed with mice of the same genetic background (C57BL/6J) that are homozygous for an effective null allele of tyrosinase (Tyz(c-2F/c-2F)) over two generations to create mice with four distinct genotypes: PAX2(A220G/+) Tyr(+/-2F,) PAX2(A220G/+) Tyr(c-2F/c-2F), PAX2(+/+) Tyr(c-2F/+), and PAX2(+/+) Tyr(c-2F/c-2F). Mouse optic nerves were examined clinically and histologically. Axon number was assessed in a masked fashion in optic nerves from mice of all four genotypes and compared with parental strains. RESULTS Mice heterozygous for a PAX2 mutation show reduced optic nerve axon number compared with age-matched controls. Tyrosinase does not appear to modify this phenotype. CONCLUSIONS Our results show that PAX2 is important in determining axon number in mouse optic nerve. The developmental effects of tyrosinase and PAX2 mutation appear to act via different pathways. C1 [Alur, Ramakrishna P.; Brooks, Brian P.] NEI, Ophthalm Gent & Visual Funct Branch, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA. [Cox, Terry A.] NEI, Div Epidemiol & Clin Res, NIH, Dept Hlth & Human Serv, Bethesda, MD USA. [Crawford, Mary Alice] NEI, Immunol Lab, NIH, Dept Hlth & Human Serv, Bethesda, MD USA. [Gong, Xiaohua] Univ Calif Berkeley, Sch Optometry, Berkeley, CA 94720 USA. [Gong, Xiaohua] Univ Calif Berkeley, Vis Sci Program, Berkeley, CA 94720 USA. RP Brooks, BP (reprint author), NEI, Ophthalm Gent & Visual Funct Branch, NIH, Dept Hlth & Human Serv, Bldg 10,Room 10N226,MSC 1860,10 Ctr Dr, Bethesda, MD 20892 USA. EM brooksb@mail.nih.gov FU Intramural NIH HHS [Z99 EY999999]; NEI NIH HHS [R01 EY013849, R01 EY013849-02, EY013849] NR 23 TC 5 Z9 5 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 1091-8531 J9 J AAPOS JI J. AAPOS PD APR PY 2008 VL 12 IS 2 BP 117 EP 121 DI 10.1016/j.jaapos.2007.08.007 PG 5 WC Ophthalmology; Pediatrics SC Ophthalmology; Pediatrics GA 293BK UT WOS:000255309600004 PM 18083586 ER PT J AU Giedd, JN AF Giedd, Jay N. TI The teen brain: Insights from neuroimaging SO JOURNAL OF ADOLESCENT HEALTH LA English DT Review DE child; adolescent; development; MRI; DTI; MT; fMRI; gray matter; white matter ID AGE-RELATED-CHANGES; WHITE-MATTER; MAGNETIZATION-TRANSFER; CORPUS-CALLOSUM; COGNITIVE-DEVELOPMENT; CORTICAL DEVELOPMENT; SEXUAL-DIMORPHISM; READING-ABILITY; CEREBRAL-CORTEX; EARLY ADULTHOOD AB Few parents of a teenager are surprised to bear that the brain of a 16-year-old is different from the brain of an 8-year-old. Yet to pin down these differences in a rigorous scientific way has been elusive. Magnetic resonance imaging, with the capacity to provide exquisitely accurate quantifications of brain anatomy and physiology without the use of ionizing radiation, has launched a new era of adolescent neuroscience. Longitudinal studies of subjects from ages 3-30 years demonstrate a general pattern of childhood peaks of gray matter followed by adolescent declines, functional and structural increases in connectivity and integrative processing, and a changing balance between limbic/subcortical and frontal lobe functions, extending well into young adulthood. Although overinterpretation and premature application of neuroimaging findings for diagnostic purposes remains a risk, converging data from multiple imaging modalities is beginning to elucidate the implications of these brain changes on cognition, emotion, and behavior. (c) 2008 Society for Adolescent Medicine. All rights reserved. C1 NIMH, Child Psychiat Branch, Brain Imaging Unit, Bethesda, MD 20892 USA. RP Giedd, JN (reprint author), NIMH, Child Psychiat Branch, Brain Imaging Unit, Bldg 10,Room 4C110,10 Ctr Dr, Bethesda, MD 20892 USA. EM jg@nih.gov RI Giedd, Jay/A-3080-2008; Giedd, Jay/B-7302-2012; Giedd, Jay/J-9644-2015 OI Giedd, Jay/0000-0003-0827-3460; Giedd, Jay/0000-0003-2002-8978 NR 87 TC 291 Z9 300 U1 7 U2 68 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1054-139X J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD APR PY 2008 VL 42 IS 4 BP 335 EP 343 DI 10.1016/j.jadohealth.2008.01.007 PG 9 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA 282CV UT WOS:000254546100005 PM 18346658 ER PT J AU Casolaro, V Fang, X Tancowny, B Fan, JS Wu, F Srikantan, S Asaki, SY De Fani, U Huang, SK Gorospe, M Atasoy, UX Stellato, C AF Casolaro, Vincenzo Fang, Xi Tancowny, Brian Fan, Jinshui Wu, Fan Srikantan, Subramanya Asaki, S. Yukiko De Fani, Umberto Huang, Shau-Ku Gorospe, Myriam Atasoy, Ulus X. Stellato, Cristiana TI Posttranscriptional regulation of IL-13 in T cells: Role of the RNA-binding protein HuR SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Article DE asthma; inflammation; mRAA turnover; posttranscriptional gene regulation; RNA-binding proteins; IL-13; T(H)2 cytokines; T cells ID INTERLEUKIN-2 MESSENGER-RNA; STABILIZING FACTOR HUR; GENE-EXPRESSION; RICH ELEMENT; 3'-UNTRANSLATED REGION; TNF-ALPHA; ACTIVATION; TURNOVER; DECAY; INVOLVEMENT AB Background: IL-13, a critical cytokine in allergy, is regulated by as-yet-elusive mechanisms. Objective: We investigated IL-13 posttranscriptional regulation by HuR, a protein associating with adenylate-uridylate-rich elements in the 3' untranslated regions (UTRs) of mRNA, promoting mRNA stability and translation. Methods: IL-13 mRNA decay was monitored in human T(H)2-skewed cells by using the transcriptional inhibitor actinomycin D. The IL-13 3'UTR was subcloned into an inducible beta-globin reporter transiently expressed in H2 cells in the absence or presence of overexpressed HuR. Association of HuR with IL-13 mRNA was detected by means of immunoprecipitation of ribonucleoprotein complexes and a biotin pull-down assay. The effects of HuR transient overexpression and silencing on IL-13 expression were investigated. Results: IL-13 mRNA half-life increased significantly in restimulated T(H)2-skewed cells compared with baseline values. Decay of beta-globin mRNA was significantly faster in H2 cells transfected with the IL-13 3'UTR-containing plasmid than in those carrying a control vector. HuR overexpression increased the beta-globin IL-13 3'-UTR reporter half-life. Significant enrichment of IL-13 mRNA was produced by means of immunoprecipitation of Jurkat cell ribonucleoprotein complexes with anti-HuR. HuR binding to the IL-13 3'UTR was confirmed by means of pull-down assay of biotin-labeled RNA probes spanning the IL-13 3'UTR. Two-dimensional Western blot analysis showed stimulus-induced posttranslational modification of HuR. In Jurkat cells mitogen-induced IL-13 mRNA was significantly affected by HuR overexpression and silencing. Conclusions: Mitogen-induced IL-13 expression involves changes in transcript turnover and a change in phosphorylation of HuR and its association with the mRNA 3'UTR. C1 [Casolaro, Vincenzo; Fang, Xi; Tancowny, Brian; Fan, Jinshui; Wu, Fan; Asaki, S. Yukiko; De Fani, Umberto; Huang, Shau-Ku; Stellato, Cristiana] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Atasoy, Ulus X.] Univ Missouri, Columbia, MO 65211 USA. [Srikantan, Subramanya; Gorospe, Myriam] NIH, NIA, Baltimore, MD USA. RP Stellato, C (reprint author), Johns Hopkins Asthma & Allergy Ctr, Div Clin Immunol & Allergy, 5501 Hopkins Bayview Circle, Baltimore, MD 21224 USA. EM stellato@jhmi.edu RI Casolaro, Vincenzo/E-9144-2010; Huang, Shau-Ku/F-5509-2010; Stellato, Cristiana/P-3001-2015; OI Casolaro, Vincenzo/0000-0001-9810-0488; Stellato, Cristiana/0000-0002-1294-8355; srikantan, subramanya/0000-0003-1810-6519 FU NIAID NIH HHS [R01 AI041463-07, R01 AI041463-10, R01 AI041463-09, R01 AI041463, R01 AI060990, R01 AI041463-06A2, R01 AI041463-08] NR 51 TC 29 Z9 30 U1 0 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0091-6749 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD APR PY 2008 VL 121 IS 4 BP 853 EP 859 DI 10.1016/j.jaci.2007.12.1166 PG 7 WC Allergy; Immunology SC Allergy; Immunology GA 286YY UT WOS:000254884000007 PM 18279945 ER PT J AU Salt, BH Niemela, JE Pandey, R Hanson, EP Deering, RP Quinones, R Jain, A Orange, JS Gelfand, EW AF Salt, Bryn H. Niemela, Julie E. Pandey, Rahul Hanson, Eric P. Deering, Raquel P. Quinones, Ralph Jain, Ashish Orange, Jordan S. Gelfand, Erwin W. TI IKBKG (nuclear factor-kappa B essential modulator) mutation can be associated with opportunistic infection without impairing Toll-like receptor function SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Article DE NEMO; Toll-like receptors ID ANHIDROTIC ECTODERMAL DYSPLASIA; HYPER-IGM SYNDROME; IKK-GAMMA GENE; INCONTINENTIA PIGMENTI; T-CELL; IMMUNE-DEFICIENCY; HUMAN-DISEASE; NEMO; IMMUNODEFICIENCY; ACTIVATION AB Background: Patients with hypomorphic nuclear factor-kappa B essential modulator (NEMO) mutations have extensive phenotypic variability that can include atypical infectious susceptibility. Objective: This study may provide important insight into immunologic mechanisms of host defense. Methods: Immunologic evaluation, including studies of Toll-like receptor (TLR) function, was performed in a 6-month-old boy with normal ectodermal development who was diagnosed with Pneumocystis pneumonia and cytomegalovirus sepsis. Results: Genomic and cDNA sequencing demonstrated a novel NEMO missense mutation, 337G->A, predicted to cause a D113N (aspartic acid to asparagine) substitution in the first coiled-coil region of the NEMO protein. Quantitative serum immunoglobulins, lymphocyte subset numbers, and mitogen-induced lymphocyte proliferation were essentially normal. The PBMC responses to TLR ligands were also surprisingly normal, whereas natural killer cell cytolytic activity, T-cell proliferative responses to specific antigens, and T-cell receptor-induced NF-kappa B activation were diminished. Conclusion: Unlike the unique NEMO mutation described here, the most commonly reported mutations are clustered at the 3' end in the tenth exon, which encodes a zinc finger domain. Because specific hypomorphic variants of NEMO are associated with distinctive phenotypes, this particular NEMO mutation highlights a dispensability of the region including amino acid 113 for TLR signaling and ectodysplasin A receptor function. This region is required for certain immunoreceptor functions as demonstrated by his susceptibility to infections as well as natural killer cell and T-cell defects. C1 [Pandey, Rahul; Hanson, Eric P.; Deering, Raquel P.; Orange, Jordan S.] Childrens Hosp Philadelphia, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USA. [Salt, Bryn H.; Gelfand, Erwin W.] Natl Jewish Med & Res Ctr, Dept Pediat, Denver, CO USA. [Niemela, Julie E.; Jain, Ashish] NIH, Bethesda, MD 20892 USA. [Quinones, Ralph] Childrens Hosp, Denver, CO 80218 USA. RP Orange, JS (reprint author), Childrens Hosp Philadelphia, Joseph Stokes Jr Res Inst, 3615 Civ Ctr Blvd,ARC 1016H, Philadelphia, PA 19104 USA. EM orange@mail.med.upenn.edu; gelfande@njc.org RI Orange, Jordan/D-5239-2009; OI Niemela, Julie/0000-0003-4197-3792; orange, jordan/0000-0001-7117-7725 FU NCI NIH HHS [T32 CA009140, T32 CA009140-34] NR 30 TC 20 Z9 21 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0091-6749 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD APR PY 2008 VL 121 IS 4 BP 976 EP 982 DI 10.1016/j.jaci.2007.11.014 PG 7 WC Allergy; Immunology SC Allergy; Immunology GA 286YY UT WOS:000254884000024 PM 18179816 ER PT J AU Lodge, JW Fletcher, BL Brown, SS Parham, AJ Fernando, RA Collins, BJ AF Lodge, Jon W. Fletcher, Brenda L. Brown, Sherri S. Parham, Angela J. Fernando, Reshan A. Collins, Bradley J. TI Determination of lovastatin hydroxy acid in female B6C3F(1) mouse serum SO JOURNAL OF ANALYTICAL TOXICOLOGY LA English DT Article ID LIQUID-CHROMATOGRAPHY; REDUCTASE; ATORVASTATIN; PRAVASTATIN; METABOLISM; INHIBITOR; PLASMA C1 [Lodge, Jon W.; Fletcher, Brenda L.; Brown, Sherri S.; Parham, Angela J.; Fernando, Reshan A.] RTI Int, Res Triangle Pk, NC 27709 USA. [Collins, Bradley J.] NIEHS, Natl Toxicol Program, Res Triangle Pk, NC 27709 USA. RP Lodge, JW (reprint author), RTI Int, POB 12194, Res Triangle Pk, NC 27709 USA. FU NIEHS NIH HHS [N01-ES-05455] NR 8 TC 5 Z9 6 U1 0 U2 3 PU PRESTON PUBL INC PI NILES PA 7800 MERRIMAC AVE PO BOX 48312, NILES, IL 60648 USA SN 0146-4760 J9 J ANAL TOXICOL JI J. Anal. Toxicol. PD APR PY 2008 VL 32 IS 3 BP 248 EP 252 PG 5 WC Chemistry, Analytical; Toxicology SC Chemistry; Toxicology GA 297MN UT WOS:000255620900007 PM 18397577 ER PT J AU Dotis, J Simitsopoulou, M Dalakiouridou, M Konstantinou, T Panteliadis, C Walsh, TJ Roilides, E AF Dotis, John Simitsopoulou, Maria Dalakiouridou, Maria Konstantinou, Thomai Panteliadis, Christos Walsh, Thomas J. Roilides, Emmanuel TI Amphotericin B formulations variably enhance antifungal activity of human neutrophils and monocytes against Fusarium solani: comparison with Aspergillus fumigatus SO JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY LA English DT Article DE filamentous fungi; phagocytes; hyphal damage; oxidative burst ID LIPID FORMULATIONS; FUNGAL-INFECTIONS; SUPEROXIDE ANION; HUMAN PHAGOCYTES; DAMAGE; PHARMACOKINETICS; EPIDEMIOLOGY; CYTOKINES; INVITRO; AGENTS AB Objectives: Lipid formulations of amphotericin B (AMBF) are widely used in the treatment of life-threatening infections caused by Aspergillus fumigatus and Fusarium solani. We aimed to compare the immunomodulatory effects of four AMBF, deoxycholate (DAMB), liposomal (LAMB), lipid complex (ABLC) and colloidal dispersion (ABCD), on the oxidative antifungal activities of human neutrophils (PMNs) and monocytes (MNCs) against hyphae of A. fumigatus and F. solani. Methods: Human PMNs and MNCs were pre-incubated with 1 or 5 mg/L DAMB and 5 or 25 mg/L for each of LAMB, ABLC and ABCD. Hyphal damage was then assessed by XTT assay, and O-2(-) production was assessed by cytochrome c assay. Results: All agents resulted in increased hyphal damage induced by phagocytes against both A. fumigatus and F. solani (P < 0.05). The high concentrations of AMBF elicited higher phagocyte-induced hyphal damage of both fungi than the low concentrations. There was, however, no consistent superiority of any of the AMBF or substantial effector cell:target ratio-dependent differences in the degree of hyphal damage enhancement. By comparison, O-2(-) produced by PMNs or MNCs upon hyphal challenge was not generally affected by any of the AMBF. F. solani hyphae were significantly more resistant to H2O2 than A. fumigatus. Conclusions: These findings suggest that AMBF have enhancing effects of variable degree on phagocyte-induced hyphal damage of A. fumigatus and F. solani. Other fungicidal mechanisms, perhaps non-oxidative, are more likely to mediate these immunomodulatory effects of AMBF on host defence against the two medically important filamentous fungi. C1 [Dotis, John; Simitsopoulou, Maria; Dalakiouridou, Maria; Konstantinou, Thomai; Panteliadis, Christos; Roilides, Emmanuel] Aristotle Univ Thessaloniki, Hippokrat Hosp, Dept Paediat 3, Infect Dis Lab,Sch Med, GR-54642 Thessaloniki, Greece. [Simitsopoulou, Maria] Inst Educ Technol, Dept Med Labs, Lab Med Biotechnol, Thessaloniki 57400, Greece. [Walsh, Thomas J.; Roilides, Emmanuel] NCI, Immunocompromised Host Sect, Bethesda, MD 20892 USA. RP Roilides, E (reprint author), Aristotle Univ Thessaloniki, Hippokrat Hosp, Dept Paediat 3, Infect Dis Lab,Sch Med, Konstantinoupoleos 49, GR-54642 Thessaloniki, Greece. EM roilides@med.auth.gr FU Intramural NIH HHS NR 33 TC 11 Z9 12 U1 0 U2 1 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0305-7453 J9 J ANTIMICROB CHEMOTH JI J. Antimicrob. Chemother. PD APR PY 2008 VL 61 IS 4 BP 810 EP 817 DI 10.1093/jac/dkn036 PG 8 WC Infectious Diseases; Microbiology; Pharmacology & Pharmacy SC Infectious Diseases; Microbiology; Pharmacology & Pharmacy GA 278NW UT WOS:000254294600009 PM 18272514 ER PT J AU Rubinson, KA Stanley, C Krueger, S AF Rubinson, Kenneth A. Stanley, Christopher Krueger, Susan TI Small-angle neutron scattering and the errors in protein structures that arise from uncorrected background and intermolecular interactions SO JOURNAL OF APPLIED CRYSTALLOGRAPHY LA English DT Article ID X-RAY; WATER; HYDRATION; EXCHANGE; DENSITY; CHARGE; LIGHT; SANS AB Small-angle neutron scattering ( SANS) provides a unique method to probe soft matter in the 10-100 nm length scale in solutions. In order to determine the shape and size of biological macromolecular structures correctly with SANS, a background-subtracted, undistorted scattering curve must be measured, and the required accuracy and precision is especially needed at the short-length-scale limit. A true scattering curve is also needed to discern whether intermolecular interactions are present, which also are probed in the SANS experiment. This article shows how to detect intermolecular interactions so that subsequent structure modeling can be performed using only data that do not contain such contributions. It is also shown how control of many factors can lead to an accurate baseline, or background, correction for scattering from proteins, especially to account for proton incoherent scattering. Failure to make this background correction properly from proteins, polymers, nucleic acids and lipids can result in incorrect values for the calculated shapes and sizes of the molecules as well as the derived magnitudes of the intermolecular interactions. C1 [Rubinson, Kenneth A.; Stanley, Christopher; Krueger, Susan] NIST, NIST Ctr Neutron Res, Gaithersburg, MD 20899 USA. [Rubinson, Kenneth A.] Wright State Univ, Dept Biochem & Mol Biol, Dayton, OH 45435 USA. [Stanley, Christopher] NICHHD, Lab Phys & Struct Biol, NIH, Bethesda, MD 20892 USA. RP Rubinson, KA (reprint author), NIST, NIST Ctr Neutron Res, Gaithersburg, MD 20899 USA. EM rubinson@nist.gov; susan.krueger@nist.gov OI Stanley, Christopher/0000-0002-4226-7710 NR 27 TC 14 Z9 14 U1 1 U2 13 PU INT UNION CRYSTALLOGRAPHY PI CHESTER PA 2 ABBEY SQ, CHESTER, CH1 2HU, ENGLAND SN 1600-5767 J9 J APPL CRYSTALLOGR JI J. Appl. Crystallogr. PD APR PY 2008 VL 41 BP 456 EP 465 DI 10.1107/S0021889808004950 PN 2 PG 10 WC Chemistry, Multidisciplinary; Crystallography SC Chemistry; Crystallography GA 274HP UT WOS:000253992700026 ER PT J AU Sviridov, D Mukhamedova, N Remaley, AT Chin-Dusting, J Nestel, P AF Sviridov, Dmitri Mukhamedova, Nigora Remaley, Alan T. Chin-Dusting, Jaye Nestel, Paul TI Antiatherogenic functionality of high density lipoprotein: how much versus how good SO JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS LA English DT Review DE atherosclerosis; inflammation; oxidation; thrombosis ID APOLIPOPROTEIN-A-I; REVERSE CHOLESTEROL TRANSPORT; CORONARY-ARTERY-DISEASE; SCAVENGER RECEPTOR BI; ACUTE-PHASE RESPONSE; SERUM-AMYLOID-A; ANTIINFLAMMATORY PROPERTIES; ENDOTHELIAL-CELLS; PRE-BETA; INFLAMMATORY/ANTIINFLAMMATORY PROPERTIES AB Plasma concentration of high density lipoprotein (HDL) is one of the most reliable negative risk factors for CVD. There is however convincing experimental and clinical evidence that plasma concentration of HDL does not convey the full picture of atheroprotective properties of HDL. HDL functionality, i.e. the ability of HDL to perform its many atheroprotective functions, is partly independent of HDL concentration and may be as important, if not more important, in determining the atheroprotective capacity of HDL. The capacity of HDL to support cholesterol efflux, its anti-inflammatory, anti-oxidant, anti-thrombotic and other atheroprotective functions are affected dramatically in conditions like coronary artery disease, chronic and acute inflammation, diabetes as well as through various interventions. The mechanisms connecting changes in HDL functionality to HDL structure are only beginning to emerge. Modifications of HDL proteins and lipids, such as advanced glycation. and oxidation, changes in HDL composition and size of HDL particles, changes in abundance of various proteins and lipids carried by HDL are among factors affecting HDL functionality. A single common denominator reflecting the multiple HDL functions is yet to be found and may not exist leaving direct measurements of each HDL function as the way to assess atheroprotective capacity of HDL. C1 [Sviridov, Dmitri; Mukhamedova, Nigora; Chin-Dusting, Jaye; Nestel, Paul] Baker Heart Res Inst, Melbourne, Vic 8008, Australia. [Remaley, Alan T.] NHLBI, NIH, Bethesda, MD 20892 USA. RP Sviridov, D (reprint author), Baker Heart Res Inst, POB 6492 St Kilda Rd Cent, Melbourne, Vic 8008, Australia. EM Dmitri.Sviridov@baker.edu.au RI Sviridov, Dmitri/E-7943-2010 NR 100 TC 73 Z9 81 U1 0 U2 3 PU JAPAN ATHEROSCLEROSIS SOC PI TOKYO PA NICHINAI-KAIKAN B1, 3-28-8 HONGO BUNKYO-KU, TOKYO, 113-0033, JAPAN SN 1340-3478 EI 1880-3873 J9 J ATHEROSCLER THROMB JI J. Atheroscler. Thromb. PD APR PY 2008 VL 15 IS 2 BP 52 EP 62 PG 11 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 304PB UT WOS:000256120300002 PM 18385533 ER PT J AU Idol, JR Addington, AM Long, RT Rapoport, JL Green, ED AF Idol, Jacquelyn R. Addington, Anjene M. Long, Robert T. Rapoport, Judith L. Green, Eric D. TI Sequencing and analyzing the t(1;7) reciprocal translocation breakpoints associated with a case of childhood-onset schizophrenia/autistic disorder SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS LA English DT Article DE schizophrenia; autism; translocation; genetics; genome analysis; cytogenetics ID HUMAN INHERITED DISEASE; AUTISM SPECTRUM; PHYSICAL MAP; HUMAN GENOME; 7Q; IDENTIFICATION; CHROMOSOME-1; POPULATION; FAMILIES; CHILDREN AB We characterized a t(1;7)(p22;q21) reciprocal translocation in a patient with childhood-onset schizophrenia (COS) and autism using genome mapping and sequencing methods. Based on genomic maps of human chromosome 7 and fluorescence in situ hybridization (FISH) studies, we delimited the region of 7q21 harboring the translocation breakpoint to a similar to 16-kb interval. A cosmid containing the translocation-associated 1:7 junction on der(1) was isolated and sequenced, revealing the positions on chromosomes 1 and 7, respectively, where the translocation occurred. PCR-based studies enabled the isolation and sequencing of the reciprocal 7:1 junction on der(7). No currently recognized gene on either chromosome appears to be disrupted by the translocation. We further found no evidence for copy-number differences in the genomic regions flanking the translocation junctions in the patient. Our efforts provide sequence-based information about a schizophrenia/autism-associated translocation, and may facilitate future studies investigating the genetic bases of these disorders. C1 [Idol, Jacquelyn R.; Green, Eric D.] NHGRI, Genome Technol Branch, NIH, Bethesda, MD 20892 USA. [Green, Eric D.] NHGRI, NIH Intramural Sequencing Ctr, NIH, Bethesda, MD 20892 USA. [Addington, Anjene M.; Long, Robert T.; Rapoport, Judith L.] NIMH, Child Psychiat Branch, NIH, Bethesda, MD 20892 USA. RP Green, ED (reprint author), NHGRI, Genome Technol Branch, NIH, 50 South Dr,Bldg 50 Rm, Bethesda, MD 20892 USA. EM egreen@nhgri.nih.gov FU Intramural NIH HHS NR 34 TC 5 Z9 5 U1 2 U2 3 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0162-3257 J9 J AUTISM DEV DISORD JI J. Autism Dev. Disord. PD APR PY 2008 VL 38 IS 4 BP 668 EP 677 DI 10.1007/s10803-007-0435-8 PG 10 WC Psychology, Developmental SC Psychology GA 275XO UT WOS:000254105700008 PM 17879154 ER PT J AU Borgnia, MJ Subramaniam, S Milne, JLS AF Borgnia, Mario J. Subramaniam, Sriram Milne, Jacqueline L. S. TI Three-dimensional imaging of the highly bent architecture of Bdellovibrio bacteriovorus by using cryo-electron tomography SO JOURNAL OF BACTERIOLOGY LA English DT Article ID ATOMIC-FORCE MICROSCOPY; ESCHERICHIA-COLI; INORGANIC POLYPHOSPHATE; BACTERIAL CYTOSKELETON; LIFE-CYCLE; CELL-SHAPE; MUREIN; VISUALIZATION; MORPHOGENESIS; PENETRATION AB Bdellovibrio bacteriovorus cells are small deltaproteobacterial cells that feed on other gram-negative bacteria, including human pathogens. Using cryo-electron tomography, we demonstrated that B. bacteriovorus cells are capable of substantial flexibility and local deformation of the outer and inner membranes without loss of cell integrity. These shape changes can occur in less than 2 min, and analysis of the internal architecture of highly bent cells showed that the overall distribution of molecular machines and the nucleoid is similar to that in moderately bent cells. B. bacteriovorus cells appear to contain an extensive internal network of short and long filamentous structures. We propose that rearrangements of these structures, in combination with the unique properties of the cell envelope, may underlie the remarkable ability of B. bacteriovorus cells to find and enter bacterial prey. C1 [Borgnia, Mario J.; Subramaniam, Sriram; Milne, Jacqueline L. S.] NCI, Cell Biol Lab, Natl Inst Hlth, Ctr Canc Res, Bethesda, MD 20892 USA. RP Milne, JLS (reprint author), NCI, Cell Biol Lab, Natl Inst Hlth, Ctr Canc Res, Bldg 50,Room 4306,50 South Dr, Bethesda, MD 20892 USA. EM jmilne@nih.gov NR 39 TC 28 Z9 28 U1 0 U2 13 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0021-9193 J9 J BACTERIOL JI J. Bacteriol. PD APR PY 2008 VL 190 IS 7 BP 2588 EP 2596 DI 10.1128/JB.01538-07 PG 9 WC Microbiology SC Microbiology GA 278YX UT WOS:000254323300038 PM 18203829 ER PT J AU Boroumand, S Garcia, AI Selwitz, RH Goodman, HS AF Boroumand, Shahdokht Garcia, A. Isabel Selwitz, Robert H. Goodman, Harold S. TI Knowledge and opinions regarding oral cancer among Maryland dental students SO JOURNAL OF CANCER EDUCATION LA English DT Article ID HUMAN-PAPILLOMAVIRUS; SOCIETY GUIDELINES; RISK; STATISTICS; NECK; HEAD AB Background. Most oral cancers are diagnosed at late stages. Health care providers, particularly dentists, play a critical role in early detection of oral cancers and should be knowledgeable and skillful in oral cancer diagnosis. In this study, we assessed knowledge and opinions regarding oral cancer among dental students in Maryland. Methods. A cross-sectional survey was conducted among Maryland dental students in 2005. Results. The response rate was 59.6%. Knowledge of oral cancer was low among freshmen and significantly different from other classes. There was no statistically significant difference between 2nd-, 3rd- and 4th-year students in terms of level of oral cancer knowledge. The results revealed inadequate confidence among junior and senior students with regard to oral cancer examination and lymph node palpation. Conclusions. Findings from this study identify areas that need reinforcement in Maryland dental school's curriculum regarding oral cancer education. This survey approach could be a model for other dental schools in the United States or overseas. C1 [Boroumand, Shahdokht; Garcia, A. Isabel] Natl Inst Dent & Craniofacial Res, NIH, Bethesda, MD 20892 USA. [Selwitz, Robert H.] Univ Florida, Coll Dent, Duval Cty Hlth Dept, Jacksonville, FL USA. [Goodman, Harold S.] Univ Maryland, Baltimore Coll Dent Surg, Baltimore, MD 21201 USA. RP Boroumand, S (reprint author), Natl Inst Dent & Craniofacial Res, NIH, 6701 Democracy Blvd,6th Floor,Room 663, Bethesda, MD 20892 USA. EM boroumands@nidcr.nih.gov NR 28 TC 9 Z9 9 U1 0 U2 0 PU LAWRENCE ERLBAUM ASSOC INC-TAYLOR & FRANCIS PI PHILADELPHIA PA 325 CHESTNUT STREET, STE 800, PHILADELPHIA, PA 19106 USA SN 0885-8195 J9 J CANCER EDUC JI J. Cancer Educ. PD APR-JUN PY 2008 VL 23 IS 2 BP 85 EP 91 DI 10.1080/08858190701821238 PG 7 WC Oncology; Education, Scientific Disciplines; Public, Environmental & Occupational Health SC Oncology; Education & Educational Research; Public, Environmental & Occupational Health GA 319WT UT WOS:000257196400005 PM 18569243 ER PT J AU Thompson, VLS Cavazos-Rehg, P Tate, KY Gaier, A AF Thompson, Vetta L. Sanders Cavazos-Rehg, Patricia Tate, Kimberly Y. Gaier, Amy TI Cancer information seeking among African Americans SO JOURNAL OF CANCER EDUCATION LA English DT Article ID HEALTH-CARE PROVIDERS; CHRONIC ILLNESS; BREAST-CANCER; SERVICE; DISPARITIES; IMPACT AB Background. Relatively little is known about the factors that impact African Americans' health information seeking, a behavior relevant to cancer disparity. Methods. In this article, we examine African American cancer information seeking using data from Cancer Information Service (CIS) call data (N = 32,834 African American callers). Results. Compared to members of other racial groups, fewer African American callers sought information on prevention and psychosocial support. African American calls were likely to result in information on medical referrals and support services. Conclusions. Increased knowledge of CIS resources relevant to treatment and support may increase African American use of CIS. C1 [Thompson, Vetta L. Sanders; Tate, Kimberly Y.] St Louis Univ, Sch Publ Hlth, Dept Community Hlth, Hlth Commun Res Lab, St Louis, MO 63104 USA. [Cavazos-Rehg, Patricia] Washington Univ, Sch Med, Div Hlth Behav Res, St Louis, MO USA. [Gaier, Amy] NCI, Canc Informat Serv, Bethesda, MD 20892 USA. RP Thompson, VLS (reprint author), St Louis Univ, Sch Publ Hlth, Dept Community Hlth, Hlth Commun Res Lab, 3545 Lafayette Ave, St Louis, MO 63104 USA. EM sandervs@slu.edu FU NCI NIH HHS [CA-P50-95815] NR 28 TC 8 Z9 8 U1 1 U2 5 PU LAWRENCE ERLBAUM ASSOC INC-TAYLOR & FRANCIS PI PHILADELPHIA PA 325 CHESTNUT STREET, STE 800, PHILADELPHIA, PA 19106 USA SN 0885-8195 J9 J CANCER EDUC JI J. Cancer Educ. PD APR-JUN PY 2008 VL 23 IS 2 BP 92 EP 101 DI 10.1080/08858190701849429 PG 10 WC Oncology; Education, Scientific Disciplines; Public, Environmental & Occupational Health SC Oncology; Education & Educational Research; Public, Environmental & Occupational Health GA 319WT UT WOS:000257196400006 PM 18569244 ER PT J AU Strong, CD Segre, JA AF Strong, Cristina de Guzman Segre, Julia A. TI Navigating the genome SO JOURNAL OF CELL SCIENCE LA English DT Editorial Material ID SEQUENCES; ELEMENTS; TOOLS C1 [Strong, Cristina de Guzman; Segre, Julia A.] NHGRI, Natl Inst Hlth, Bethesda, MD 20892 USA. RP Segre, JA (reprint author), NHGRI, Natl Inst Hlth, 49 Convent Dr, Bethesda, MD 20892 USA. EM jsegre@mail.nih.gov NR 15 TC 0 Z9 0 U1 0 U2 1 PU COMPANY OF BIOLOGISTS LTD PI CAMBRIDGE PA BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE CB4 4DL, CAMBS, ENGLAND SN 0021-9533 EI 1477-9137 J9 J CELL SCI JI J. Cell Sci. PD APR PY 2008 VL 121 IS 7 BP 921 EP 923 DI 10.1242/jcs.022400 PG 3 WC Cell Biology SC Cell Biology GA 283TV UT WOS:000254660300001 ER PT J AU Sagelius, H Rosengardten, Y Hanif, M Erdos, MR Rozell, B Collins, FS Eriksson, M AF Sagelius, Hanna Rosengardten, Ylva Hanif, Mubashir Erdos, Michael R. Rozell, Bjoern Collins, Francis S. Eriksson, Maria TI Targeted transgenic expression of the mutation causing Hutchinson-Gilford progeria syndrome leads to proliferative and degenerative epidermal disease SO JOURNAL OF CELL SCIENCE LA English DT Article DE Hutchinson-Gilford progeria syndrome; progerin; LMNA gene; lamin A/C; prelamin a; tet-off system; K5tTA; epidermal hyperplasia ID LAMIN-A; NUCLEAR-ENVELOPE; GENE-EXPRESSION; MICE; PHENOTYPES; DEFECTS; SKIN; FIBROBLASTS; DEFICIENCY; DYSTROPHY AB Hutchinson-Gilford progeria syndrome (HGPS) is a rare human genetic disorder characterized by striking progeroid features. Clinical findings in the skin include scleroderma, alopecia and loss of subcutaneous fat. HGPS is usually caused by a dominant-negative mutation in LMNA, a gene that encodes two major proteins of the inner nuclear lamina: lamin A and lamin C. We have generated tetracycline-inducible transgenic lines that carry a minigene of human LMNA under the control of a tet-operon. Two mouse lines were created: one carrying the wildtype sequence of LMNA and the other carrying the most common HGPS mutation. Targeted expression of the HGPS mutation in keratin-5-expressing tissues led to abnormalities in the skin and teeth, including fibrosis, loss of hypodermal adipocytes, structural defects in the hair follicles and sebaceous glands, and abnormal incisors. The severity of the defects was related to the level of expression of the transgene in different mouse lines. These transgenic mice appear to be good models for studies of the molecular mechanisms of skin abnormalities in HGPS and other related disorders. C1 [Sagelius, Hanna; Rosengardten, Ylva; Hanif, Mubashir; Eriksson, Maria] Karolinska Univ Hosp, Karolinska Inst, Dept Biosci & Nutr, SE-14186 Stockholm, Sweden. [Erdos, Michael R.; Collins, Francis S.] NHGRI, Genome Technol Branch, Natl Inst Hlth, Bethesda, MD 20892 USA. [Rozell, Bjoern] Karolinska Univ Hosp, Karolinska Inst, Dept Lab Med, Clin Res Ctr, SE-14186 Stockholm, Sweden. RP Eriksson, M (reprint author), Karolinska Univ Hosp, Karolinska Inst, Dept Biosci & Nutr, SE-14186 Stockholm, Sweden. EM maria.eriksson@mednut.ki.se NR 41 TC 38 Z9 38 U1 3 U2 8 PU COMPANY OF BIOLOGISTS LTD PI CAMBRIDGE PA BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE CB4 4DL, CAMBS, ENGLAND SN 0021-9533 J9 J CELL SCI JI J. Cell Sci. PD APR PY 2008 VL 121 IS 7 BP 969 EP 978 DI 10.1242/jcs.022913 PG 10 WC Cell Biology SC Cell Biology GA 283TV UT WOS:000254660300007 PM 18334552 ER PT J AU Jensen, ED Niu, L Caretti, G Nicol, SM Teplyuk, N Stein, GS Sartorelli, V van Wijnen, AJ Fuller-Pace, FV Westendorf, JJ AF Jensen, Eric D. Niu, Lingling Caretti, Giuseppina Nicol, Samantha M. Teplyuk, Nadiya Stein, Gary S. Sartorelli, Vittorio van Wijnen, Andre J. Fuller-Pace, Frances V. Westendorf, Jennifer J. TI p68 (Ddx5) interacts with Runx2 and regulates osteoblast differentiation SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Article DE CBFa1; DEAD box; Ddx5; osteocalcin; mesodermal cell differentiation ID ESTROGEN-RECEPTOR-ALPHA; BOX RNA HELICASES; BREAST-CANCER; TRANSCRIPTIONAL COACTIVATORS; OSTEOCALCIN PROMOTER; BINDING PROTEINS; NUCLEAR MATRIX; GENE; EXPRESSION; IDENTIFICATION AB Runx2 is an essential transcription factor for osteoblast development from mesenchymal progenitors. Runx2 regulates gene expression by interacting with numerous transcription factors and co-activators to integrate signaling events within the nucleus. In this study we used affinity purification and proteomic techniques to identify novel Runx2 interacting proteins. One of these proteins is the DEAD box RNA helicase, p68 (Ddx5). p68 regulates many aspects of RNA expression, including transcription and splicing. p68 co-localized with Runx2 in punctate foci within the nucleus. In transcription assays, p68 functioned as a co-activator of Runx2, but its helicase activity was not essential for coactivation. In accordance, Runx2 transcriptional activity was muted in p68-suppressed cells. Surprisingly, osteoblast differentiation of the multipotent progenitor C2C12 cell line was accelerated by p68 suppression and Runx2 suppressed p68 expression in calvarial progenitor cells. Together these data demonstrate that p68 is a novel co-activator for Runx2, but it inhibits osteogenic differentiation of progenitor cells. Moreover Runx2 has an active role in regulating p68 levels in osteoblast precursors. Thus, crosstalk between Runx2 and p68 controls osteoblast specification and maturation at multiple levels. C1 [Westendorf, Jennifer J.] Mayo Clin, Dept Orthoped Surg, Rochester, MN 55905 USA. [Jensen, Eric D.; Niu, Lingling] Univ Minnesota, Ctr Canc, Minneapolis, MN 55455 USA. [Jensen, Eric D.; Niu, Lingling] Univ Minnesota, Dept Orthoped Surg, Minneapolis, MN 55455 USA. [Caretti, Giuseppina; Sartorelli, Vittorio] NIAMSD, Lab Muscle Stem Cells & Gene Regulat, Natl Inst Hlth, Bethesda, MD 20829 USA. [Nicol, Samantha M.; Fuller-Pace, Frances V.] Univ Dundee, Canc Biol Grp, Div Pathol & Neurosci, Ninewells Hosp & Med Sch, Dundee DD1 9SY, Scotland. [Teplyuk, Nadiya; Stein, Gary S.; van Wijnen, Andre J.] Univ Massachusetts, Sch Med, Dept Cell Biol, Worcester, MA 01655 USA. RP Westendorf, JJ (reprint author), Mayo Clin, Dept Orthoped Surg, 200 1st St SW, Rochester, MN 55905 USA. EM westendorf.jennifer@mayo.edu FU Intramural NIH HHS; NIAMS NIH HHS [AR050938, R01 AR48818, T32 AR050938, R01 AR48147, R01 AR49069, R01 AR050074, R01 AR049069] NR 40 TC 39 Z9 44 U1 0 U2 8 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD APR 1 PY 2008 VL 103 IS 5 BP 1438 EP 1451 DI 10.1002/jcb.21526 PG 14 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA 285HP UT WOS:000254768200010 PM 17960593 ER PT J AU Alessandro, R Fontana, S Giordano, M Corrado, C Colomba, P Flugy, AM Santoro, A Kohn, EC Leo, G AF Alessandro, Riccardo Fontana, Simona Giordano, Margherita Corrado, Chiara Colomba, Paolo Flugy, Anna Maria Santoro, Alessandra Kohn, Elise C. De Leo, Giacomo TI Effects of carboxyamidotriazole on in vitro models of imatinib-resistant chronic myeloid leukemia SO JOURNAL OF CELLULAR PHYSIOLOGY LA English DT Article ID CHRONIC MYELOGENOUS LEUKEMIA; SIGNAL-TRANSDUCTION INHIBITOR; TYROSINE KINASE; CALCIUM INFLUX; CELL-PROLIFERATION; CHRONIC PHASE; CANCER CELLS; APOPTOSIS; TRIAZOLE; BCR/ABL AB Although imatinib mesylate (IM) has revolutionized the treatment of chronic myeloid leukemia (CML), some patients develop resistance with progression of leukemia. Alternative or additional targeting of signaling pathways deregulated in bcr-abl-driven CML cells may provide a feasible option for improving clinical response and overcoming resistance. In this study, we show that carboxyamidotriazole (CAI), an orally bioavailable calcium influx and signal transduction inhibitor, is equally effective in inhibiting the proliferation and bcr-abl dependent- and independent-signaling pathways in imatinib-resistant CML cells. CAI inhibits phosphorylation of cellular proteins including STATS and CrkL at concentrations that induce apoptosis in IM-resistant CML cells. The combination of imatinib and CAI also down-regulated bcr-abl protein levels. Since CAI is already available for clinical use, these results suggest that it may be an effective addition to the armamentarium of drugs for the treatment of CML. C1 [Alessandro, Riccardo; Fontana, Simona; Giordano, Margherita; Corrado, Chiara; Colomba, Paolo; Flugy, Anna Maria; De Leo, Giacomo] Univ Palermo, Dipartimento Biopatol & Metodol Biomed, Sezione Biol & Genet, I-90133 Palermo, Italy. [Santoro, Alessandra] Dipartimento Ric Clin & Biotecnol AO V Cervello, Lab Ematol, Palermo, Italy. [Kohn, Elise C.] NCI, Ctr Canc Res, Pathol Lab, Mol Signalling Sect, Bethesda, MD 20892 USA. RP Alessandro, R (reprint author), Univ Palermo, Dipartimento Biopatol & Metodol Biomed, Sezione Biol & Genet, Via Divisi 83, I-90133 Palermo, Italy. EM ricale@unipa.it OI Fontana, Simona/0000-0003-4681-2170 FU Associazione Italiana per la Ricerca sul Cancro NR 52 TC 13 Z9 13 U1 2 U2 3 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0021-9541 J9 J CELL PHYSIOL JI J. Cell. Physiol. PD APR PY 2008 VL 215 IS 1 BP 111 EP 121 DI 10.1002/jcp.21290 PG 11 WC Cell Biology; Physiology SC Cell Biology; Physiology GA 280LI UT WOS:000254427900012 PM 17924401 ER PT J AU Mancino, M Strizzi, L Wechselberger, C Watanabe, K Gonzales, M Hamada, S Normanno, N Salomon, DS Bianco, C AF Mancino, Mario Strizzi, Luigi Wechselberger, Christian Watanabe, Kazuhide Gonzales, Monica Hamada, Shin Normanno, Nicola Salomon, David S. Bianco, Caterina TI Regulation of human cripto-1 gene expression by TGF-beta 1 and BMP-4 in embryonal and colon cancer cells SO JOURNAL OF CELLULAR PHYSIOLOGY LA English DT Article ID MAMMARY EPITHELIAL-CELLS; GROWTH-FACTOR-BETA; BONE MORPHOGENETIC PROTEIN-4; TGF-BETA; STEM-CELLS; TYROSINE PHOSPHORYLATION; SIGNALING PATHWAY; CARCINOMA-CELLS; TUMOR-GROWTH; DIFFERENTIATION AB Human Cripto-1 (CR-1) is a cell membrane protein that is overexpressed in several different types of human carcinomas. In the present study we investigated the mechanisms that regulate the expression of CR-1 gene in cancer cells. We cloned a 2,481 bp 5'-flanking region of the human CR-1 gene into a luciferase reporter vector and transfected NTERA-2 human embryonal carcinoma cells and LS174-T colon cancer cells to test for promoter activity. Activity of CR-1 promoter in both cell lines was modulated by two TGF-beta family members, TGF-beta 1 and BMP-4. In particular, TGF-beta 1 significantly up-regulated CR-1 promoter activity, whereas a dramatic reduction in CR-1 promoter activity was observed with BMP-4 in NTERA-2 and LS174-T cells. Changes in the CR-1 promoter activity following TGF-beta 1 and BMPA treatments correlated with changes in CR-1 mRNA and protein expression in NTEKA-2 and LS174-T cells. We also identified three Smad binding elements (SBEs) within the CR- I promoter and point mutation of SBE1 (-2,197/-2,189) significantly reduced response of the CR-1 promoter to both TGF-beta I and BMP-4 in NTERA-2 and LS174-T cells. Chromatin immunoprecipitation assay also demonstrated binding of Smad-4 to a CR- I promoter DNA sequence containing SBE1 in LSI74-T cells. Finally, BMP-4 inhibited migration of LS174-T cells and F9 mouse embryonal carcinoma cells by downregulation of CR-1 protein. In conclusion, these results suggest a differential modulation of CR-1 gene expression in embryonal and colon cancer cells by two different members of the TGF-beta family. C1 [Mancino, Mario; Strizzi, Luigi; Watanabe, Kazuhide; Gonzales, Monica; Hamada, Shin; Salomon, David S.; Bianco, Caterina] NCI, NIH, Mammary Biol & Tumorigenesis Lab, Tumor Growth Factor Sect, Bethesda, MD 20832 USA. [Wechselberger, Christian] Ctr Biomed Nanotechnol, Upper Austrian Res GmbH, Linz, Austria. [Normanno, Nicola] ITN Fdn Pascale, Cell Biol & Preclin Models Unit, Naples, Italy. RP Salomon, DS (reprint author), NCI, NIH, Mammary Biol & Tumorigenesis Lab, Tumor Growth Factor Sect, 37 Convent Dr,Bldg 37 Room 1112, Bethesda, MD 20832 USA. EM salomond@mail.nih.gov; Biancoc@mail.nih.gov FU Intramural NIH HHS; Associazione Italiana per la Ricerca sul Cancro NR 56 TC 22 Z9 22 U1 0 U2 1 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0021-9541 J9 J CELL PHYSIOL JI J. Cell. Physiol. PD APR PY 2008 VL 215 IS 1 BP 192 EP 203 DI 10.1002/jcp.21301 PG 12 WC Cell Biology; Physiology SC Cell Biology; Physiology GA 280LI UT WOS:000254427900020 PM 17941089 ER PT J AU Milner, R Hung, S Wang, X Spatz, M del Zoppo, GJ AF Milner, Richard Hung, Stephanie Wang, Xiaoyun Spatz, Maria del Zoppo, Gregory J. TI The rapid decrease in astrocyte-associated dystroglycan expression by focal cerebral ischemia is protease-dependent SO JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM LA English DT Article DE astrocytes; dystroglycan; endothelial cells; focal ischemia; microvessels; neurovascular unit ID WATER CHANNEL PROTEIN; BLOOD-BRAIN-BARRIER; EXTRACELLULAR-MATRIX; ALPHA-DYSTROGLYCAN; MUSCULAR-DYSTROPHY; BASEMENT-MEMBRANE; BETA-DYSTROGLYCAN; LAMININ ALPHA-1; CELL-MEMBRANE; COMPLEX AB During focal cerebral ischemia, the detachment of astrocytes from the microvascular basal lamina is not completely explained by known integrin receptor expression changes. Here, the impact of experimental ischemia (oxygen-glucose deprivation (OGD)) on dystroglycan expression by murine endothelial cells and astrocytes grown on vascular matrix laminin, perlecan, or collagen and the impact of middle cerebral artery occlusion on alpha beta-dystroglycan within cerebral microvessels of the nonhuman primate were examined. Dystroglycan was expressed on all cerebral microvessels in cortical gray and white matter, and the striatum. Astrocyte adhesion to basal lamina proteins was managed in part by alpha-dystroglycan, while ischemia significantly reduced expression of dystroglycan both in vivo and in vitro. Furthermore, dystroglycan and integrin alpha(6)beta(4) expressions on astrocyte end-feet decreased in parallel both in vivo and in vitro. The rapid loss of astrocyte dystroglycan during OGD appears protease-dependent, involving an matrix metalloproteinase-like activity. This may explain the rapid detachment of astrocytes from the microvascular basal lamina during ischemic injury, which could contribute to significant changes in microvascular integrity. C1 [del Zoppo, Gregory J.] Univ Washington, Med Ctr, Dept Med, Seattle, WA 98104 USA. [del Zoppo, Gregory J.] Univ Washington, Med Ctr, Dept Neurol, Seattle, WA 98104 USA. [Milner, Richard; Hung, Stephanie; Wang, Xiaoyun; del Zoppo, Gregory J.] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA USA. [Spatz, Maria] NINDS, Stroke Branch, Bethesda, MD 20892 USA. RP del Zoppo, GJ (reprint author), Univ Washington, Med Ctr, Dept Med, 325 9th Ave, Seattle, WA 98104 USA. EM grgdlzop@u.washington.edu FU NINDS NIH HHS [R01 NS53716, R01 NS26945, R01 NS053716, R37 NS038710, R01 NS026945, R37 NS38710, R37 NS038710-08, R01 NS053716-04] NR 39 TC 41 Z9 42 U1 2 U2 3 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0271-678X J9 J CEREBR BLOOD F MET JI J. Cereb. Blood Flow Metab. PD APR PY 2008 VL 28 IS 4 BP 812 EP 823 DI 10.1038/sj.jcbfm.9600585 PG 12 WC Endocrinology & Metabolism; Hematology; Neurosciences SC Endocrinology & Metabolism; Hematology; Neurosciences & Neurology GA 280GS UT WOS:000254414500014 PM 18030304 ER PT J AU Whitelock, J Ma, JL Davies, N Nielsen, N Chuang, C Rees, M Iozzo, RV Knox, S Lord, M AF Whitelock, John Ma, J. Leo Davies, Neil Nielsen, Natasja Chuang, Christine Rees, Martin Iozzo, Renato V. Knox, Sarah Lord, Megan TI Recombinant heparan sulfate for use in tissue engineering applications SO JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY LA English DT Article DE heparan sulfate; recombinant; growth factor; tissue engineering ID PERLECAN DOMAIN-I; FIBROBLAST-GROWTH-FACTOR; CARBOHYDRATE ELECTROPHORESIS FACE; TRANSGENIC PLANTS; CHONDROITIN SULFATE; ATTACHMENT SITES; FGF RECEPTORS; PROTEOGLYCAN; EXPRESSION; COLLAGEN AB BACKGROUND: Heparan sulfate (HS) is an important component of many extracellular matrices that interacts with mitogens and morphogens to guide and control tissue and organ development. These interactions are controlled by its structure, which varies when produced by different cell types and different species. The major aim of the studies reported here was to isolate and characterize the HS expressed on the N-terminal domain of human perlecan when it is expressed in human cells. RESULTS: The recombinant proteoglycan was expressed in greatest quantities when the cells were grown as monolayers in the presence of Medium 199. It was purified as a proteoglycan with a molecular weight between 75 and 150kDa, which was decorated with HS, chondroitin sulfate (CS) and keratan sulfate (KS) in a similar way to the full-length perlecan from the same cells. Compositional analysis of the glycosaminoglycan (GAG) chains suggested that it contained the same amount of CS and HS, suggesting that one of the attachment sites may not be glycosylated. The HS chains were responsible for the binding of fibroblast growth factor 2 (FGF2), while the specific roles of the CS and KS remain unclear. CONCLUSION: Expressing the N-terminal domain of the proteoglycan perlecan results in a hybrid truncated molecule that binds to growth factors via it's HS and may prove useful to add to scaffolds to encourage cells to respond to growth signals, such as those produced by the FGFs. (c) 2008 Society of Chemical Industry. C1 [Whitelock, John; Ma, J. Leo; Davies, Neil; Nielsen, Natasja; Chuang, Christine; Knox, Sarah; Lord, Megan] Univ New S Wales, Grad Sch Biomed Engn, Sydney, NSW 2052, Australia. [Rees, Martin] Heart Res Inst, Camperdown, NSW 2006, Australia. [Iozzo, Renato V.] Thomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA. [Iozzo, Renato V.] Thomas Jefferson Univ, Kimmel Canc Ctr, Philadelphia, PA 19107 USA. [Knox, Sarah] Natl Inst Dent & Craniofacial Res, Bethesda, MD USA. RP Whitelock, J (reprint author), Univ New S Wales, Grad Sch Biomed Engn, Sydney, NSW 2052, Australia. EM j.whitelock@unsw.edu.au RI Lord, Megan/D-4673-2013; OI Lord, Megan/0000-0002-0506-9811; Knox, Sarah/0000-0002-7567-083X; Rees, Martin/0000-0002-3564-5736; Iozzo, Renato/0000-0002-5908-5112 NR 39 TC 7 Z9 7 U1 0 U2 8 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 0268-2575 J9 J CHEM TECHNOL BIOT JI J. Chem. Technol. Biotechnol. PD APR PY 2008 VL 83 IS 4 BP 496 EP 504 DI 10.1002/jctb.1835 PG 9 WC Biotechnology & Applied Microbiology; Chemistry, Multidisciplinary; Engineering, Environmental; Engineering, Chemical SC Biotechnology & Applied Microbiology; Chemistry; Engineering GA 285GB UT WOS:000254764200009 ER PT J AU Rau, G Blair, KS Berghorst, L Knopf, L Skup, M Luckenbaugh, DA Pine, DS Leibenluft, E Blair, RJ AF Rau, Geoff Blair, Karina S. Berghorst, Lisa Knopf, Lisa Skup, Martha Luckenbaugh, David A. Pine, Daniel S. Leibenluft, Ellen Blair, Robert J. TI Processing of differentially valued rewards and punishments in youths with bipolar disorder or severe mood dysregulation SO JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY LA English DT Article ID SCHOOL-AGE-CHILDREN; CONDUCT PROBLEMS; RATING-SCALE; PSYCHOPATHY; COMORBIDITY; RELIABILITY; PHENOTYPES; VALIDITY; MANIA; PERSONALITY AB Background: Youths with chronic irritability and hyperarousal (i.e., severe mood dysregulation, SMD) have reward- and punishment-processing deficits distinct from those exhibited by children with episodic symptoms of mania (i.e., narrow-phenotype bipolar disorder, BD). Additionally, youths with SMD, like those with psychopathy, have prominent reactive aggression. Therefore, we hypothesized that SMD, but not BD, youths would be impaired on a decision-making task that has identified reward-and punishment-processing deficits in individuals with psychopathy. Methods: A decision-making task was used in which BD (n = 23), SMD (n = 37), and control subjects (n = 31) were asked to choose between two images associated with different levels of reward or punishment. Results: No between-group differences in task performance were found. Conclusion: These results suggest that BD, SMD, and normal youths do not differ in their ability to select between rewards and punishments of different value. Effect-size analyses suggest that this finding is not secondary to a type II error. Unlike individuals with psychopathy, neither SMD subjects nor those with BD differ from controls in their ability to select between differentially valued rewards and punishments. C1 [Rau, Geoff; Blair, Karina S.; Berghorst, Lisa; Knopf, Lisa; Skup, Martha; Luckenbaugh, David A.; Pine, Daniel S.; Leibenluft, Ellen; Blair, Robert J.] NIMH, Mood & Anxiety Program, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA. RP Rau, G (reprint author), NIMH, Mood & Anxiety Program, NIH, Dept Hlth & Human Serv, Bldg 10,Room 3N-234 10 Ctr Dr,MSC 1289, Bethesda, MD 20892 USA. EM gmr@duke.edu FU Intramural NIH HHS [Z99 MH999999, Z01 MH002786-06, Z01 MH002778-08] NR 37 TC 12 Z9 12 U1 3 U2 9 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1044-5463 J9 J CHILD ADOL PSYCHOP JI J. Child Adolesc. Psychopharmacol. PD APR PY 2008 VL 18 IS 2 BP 185 EP 196 DI 10.1089/cap.2007.0053 PG 12 WC Pediatrics; Pharmacology & Pharmacy; Psychiatry SC Pediatrics; Pharmacology & Pharmacy; Psychiatry GA 300LT UT WOS:000255826000006 PM 18439115 ER PT J AU Chen, XH Gardner, ER Price, DK Figg, WD AF Chen, Xiaohong Gardner, Erin R. Price, Douglas K. Figg, William D. TI Development and validation of an LC-MS assay for finasteride and its application to prostate cancer prevention trial sample analysis SO JOURNAL OF CHROMATOGRAPHIC SCIENCE LA English DT Article ID PERFORMANCE LIQUID-CHROMATOGRAPHY; HUMAN-PLASMA; BIOLOGICAL-FLUIDS; HYPERPLASIA; EXTRACTION; PICOGRAM C1 [Chen, Xiaohong; Figg, William D.] NCI, Clin Pharmacol Program, Ctr Canc Res, Bethesda, MD 20892 USA. [Gardner, Erin R.] NCI Frederick, Clin Pharmacol Program, SAIC Frederick Inc, Ft Detrick, MD 21702 USA. [Price, Douglas K.] NCI, Mol Pharmacol Sect, Ctr Canc Res, Bethesda, MD 20892 USA. RP Figg, WD (reprint author), NCI, Clin Pharmacol Program, Ctr Canc Res, 9000 Rockville Pike,Bldg 10,Room 5A01, Bethesda, MD 20892 USA. EM wdfigg@helix.nih.gov FU Intramural NIH HHS [NIH0011335962]; NCI NIH HHS [P01 CA 106451, P01 CA106451, P01 CA108964-02, N01 CO 12400, N01CO12400, P01 CA108964]; PHS HHS [NIH0011335962] NR 19 TC 7 Z9 7 U1 0 U2 1 PU PRESTON PUBL INC PI NILES PA 7800 MERRIMAC AVE PO BOX 48312, NILES, IL 60648 USA SN 0021-9665 J9 J CHROMATOGR SCI JI J. Chromatogr. Sci. PD APR PY 2008 VL 46 IS 4 BP 356 EP 361 PG 6 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 280MB UT WOS:000254429800013 PM 18402729 ER PT J AU Chen, XH Gardner, ER Figg, WD AF Chen, Xiaohong Gardner, Erin R. Figg, William D. TI Determination of the cyclic depsipeptide FK228 in human and mouse plasma by liquid chromatography with mass-spectrometric detection SO JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES LA English DT Article DE depsipeptide; human plasma; mouse plasma; LC/MS ID CHROMOBACTERIUM-VIOLACEUM NO-968; HISTONE DEACETYLASE INHIBITOR; FR901228; TRIAL AB An analytical method was developed and validated for the quantitative determination of the cyclic depsipeptide FK228 (romidepsin, formerly FR901228; NSC 630176), a histone deacetylase inhibitor, in human and mouse plasma. Calibration curves were linear in the concentration range of 2-1000 ng/mL. Sample pretreatment involved a liquid-liquid extraction of 0.1 mL aliquots of plasma with ethyl acetate. FK228 and the internal standard, harmine, were separated on a Zorbax SB C18 column (75 mm x 2.1 mm, 3.5 mu m), using a mobile phase composed of methanol and 0.2% formic acid. The column eluent was monitored by mass spectrometry with electrospray ionization. Accuracy and precision of four concentrations of quality control samples ranged from 101.5 to 106.4% and 0.7 to 3.5% in human plasma and 93.6 to 100.6% and 0.6 to 6.5%, in mouse plasma, respectively. This method represents a significant improvement over our previously published analytical assay for this agent, decreasing the sample volume requirements, increasing the accuracy and precision (through addition of a suitable internal standard), expanding the analytical range and validating in additional biological matrices. The developed method was applied to study the pharmacokinetics of FK228 in over 1000 clinical and preclinical samples. (c) 2008 Elsevier B.V. All rights reserved. C1 [Chen, Xiaohong; Figg, William D.] NCI, Clin Pharmacol Res Core, Bethesda, MD 20892 USA. [Gardner, Erin R.] NCI, SAIC Frederick Inc, Clin Pharmacol Program, Frederick, MD 21702 USA. RP Figg, WD (reprint author), NCI, Clin Pharmacol Res Core, 9000 Rockville Pike,Bldg 10,Room 5A01, Bethesda, MD 20892 USA. EM wdfigg@helix.nih.gov RI Figg Sr, William/M-2411-2016 FU Intramural NIH HHS [NIH0011335962, Z01 SC006536-06]; NCI NIH HHS [N01-CO-12400, N01CO12400] NR 10 TC 10 Z9 10 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1570-0232 J9 J CHROMATOGR B JI J. Chromatogr. B PD APR 1 PY 2008 VL 865 IS 1-2 BP 153 EP 158 DI 10.1016/j.jchromb.2008.02.015 PG 6 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 292XW UT WOS:000255300400022 PM 18342585 ER PT J AU Lodish, MB Powell, AC Abu-Asab, M Cochran, C Lenz, P Libutti, SK Pingpank, JF Tsokos, M Gorden, P AF Lodish, Maya B. Powell, Anathea C. Abu-Asab, Mones Cochran, Craig Lenz, Petra Libutti, Steven K. Pingpank, James F. Tsokos, Maria Gorden, Phillip TI Insulinoma and gastrinoma syndromes from a single intrapancreatic neuroendocrine tumor SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM LA English DT Article ID ZOLLINGER-ELLISON-SYNDROME; ISLET CELL-CARCINOMA; SOMATOSTATIN; PANCREAS; CURE AB Context: The insulinoma syndrome is marked by fasting hypoglycemia and inappropriate elevations of insulin. The gastrinoma syndrome is characterized by hypergastrinemia, ulcer disease, and/or diarrhea. Rarely, insulinoma and gastrinoma coexist in the same patient simultaneously. Objective: Our objective was to determine the cause of a patient's hypoglycemic episodes and peptic ulcer disease. Design and Setting: This is a clinical case report from the Clinical Research Center of the National Institutes of Health. Patient and Intervention: One patient with hypoglycemic episodes and peptic ulcer disease had a surgical resection of neuroendocrine tumor. Results: The patient was found to have a single tumor cosecreting both insulin and gastrin. Resection of this single tumor was curative. Conclusions: A single pancreatic neuroendocrine tumor may lead to the expression of both the hyperinsulinemic and hypergastrinemic syndromes. C1 [Lodish, Maya B.] NCI, NICHHD, Bethesda, MD 20892 USA. [Powell, Anathea C.; Libutti, Steven K.; Pingpank, James F.] NCI, Surg Branch, Bethesda, MD 20892 USA. [Abu-Asab, Mones; Lenz, Petra; Tsokos, Maria] NCI, Pathol Lab, Bethesda, MD 20892 USA. [Cochran, Craig; Gorden, Phillip] NIDDK, Natl Inst Hlth, Div Intramural Res, Clin Endocrinol Branch, Bethesda, MD 20892 USA. RP Gorden, P (reprint author), CRC, 10 Ctr Dr,Room 6-5940, Bethesda, MD 20892 USA. EM PhillipG@intra.niddk.nih.gov OI Abu-Asab, Mones/0000-0002-4047-1232 FU Intramural NIH HHS NR 17 TC 9 Z9 9 U1 0 U2 0 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0021-972X J9 J CLIN ENDOCR METAB JI J. Clin. Endocrinol. Metab. PD APR PY 2008 VL 93 IS 4 BP 1123 EP 1128 DI 10.1210/jc.2007-2449 PG 6 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 284AI UT WOS:000254677200004 PM 18252785 ER PT J AU Shaw, LJ Merz, CNB Azziz, R Stanczyk, FZ Sopko, G Braunstein, GD Kelsey, SF Kip, KE Cooper-DeHoff, RM Johnson, BD Vaccarino, V Reis, SE Bittner, V Hodgson, TK Rogers, W Pepine, CJ AF Shaw, Leslee J. Merz, C. Noel Bairey Azziz, Ricardo Stanczyk, Frank Z. Sopko, George Braunstein, Glenn D. Kelsey, Sheryl F. Kip, Kevin E. Cooper-DeHoff, Rhonda M. Johnson, B. Delia Vaccarino, Viola Reis, Steven E. Bittner, Vera Hodgson, T. Keta Rogers, William Pepine, Carl J. TI Postmenopausal women with a history of irregular menses and elevated androgen measurements at high risk for worsening cardiovascular event-free survival: Results from the National Institutes of Health - National heart, lung, and blood institute sponsored women's ischemia syndrome evaluation SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM LA English DT Article ID POLYCYSTIC-OVARY-SYNDROME; SYNDROME EVALUATION WISE; ENDOGENOUS SEX-HORMONES; TERM-FOLLOW-UP; MYOCARDIAL-INFARCTION; DIABETES-MELLITUS; FREE TESTOSTERONE; DISEASE; ATHEROSCLEROSIS; ASSOCIATION AB Background: Women with polycystic ovary syndrome (PCOS) have a greater clustering of cardiac risk factors. However, the link between PCOS and cardiovascular (CV) disease is incompletely described. Objective: The aim of this analysis was to evaluate the risk of CV events in 390 postmenopausal women enrolled in the National Institutes of Health-National Heart, Lung, and Blood Institute (NIH-NHLBI) sponsored Women's Ischemia Syndrome Evaluation (WISE) study according to clinical features of PCOS. Methods: A total of 104 women had clinical features of PCOS defined by a premenopausal history of irregular menses and current biochemical evidence of hyperandrogenemia. Hyperandrogenemia was defined as the top quartile of androstenedione (>= 701 pg/ml), testosterone (>= 30.9 ng/dl), or free testosterone (>= 4.5 pg/ml). Cox proportional hazard model was fit to estimate CV death or myocardial infarction (n = 55). Results: Women with clinical features of PCOS were more often diabetic (P < 0.0001), obese (P = 0.005), had the metabolic syndrome (P < 0.0001), and had more angiographic coronary artery disease (CAD) (P = 0.04) compared to women without clinical features of PCOS. Cumulative 5-yr CV event-free survival was 78.9% for women with clinical features of PCOS (n = 104) vs. 88.7% for women without clinical features of PCOS (n = 286) (P = 0.006). PCOS remained a significant predictor (P < 0.01) in prognostic models including diabetes, waist circumference, hypertension, and angiographic CAD as covariates. Conclusion: Among postmenopausal women evaluated for suspected ischemia, clinical features of PCOS are associated with more angiographic CAD and worsening CV event-free survival. Identification of postmenopausal women with clinical features of PCOS may provide an opportunity for risk factor intervention for the prevention of CAD and CV events. C1 [Shaw, Leslee J.; Merz, C. Noel Bairey] Cedars Sinai Med Ctr, Div Cardiol, Dept Med, Cedars Sinai Res Inst, Los Angeles, CA 90048 USA. [Azziz, Ricardo] Cedars Sinai Med Ctr, Dept Obstet & Gynecol, Los Angeles, CA 90048 USA. [Stanczyk, Frank Z.] Univ So Calif, Los Angeles, CA 90089 USA. [Sopko, George] NHLBI, NIH, Bethesda, MD 20814 USA. [Braunstein, Glenn D.; Hodgson, T. Keta] Cedars Sinai Med Ctr, Dept Med, Los Angeles, CA 90048 USA. [Kelsey, Sheryl F.; Kip, Kevin E.; Johnson, B. Delia] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15213 USA. [Cooper-DeHoff, Rhonda M.; Pepine, Carl J.] Univ Florida, Dept Med, Div Cardiol, Gainesville, FL 32611 USA. [Vaccarino, Viola] Emory Univ, Sch Med, Dept Med, Div Cardiol, Atlanta, GA 30332 USA. [Reis, Steven E.] Univ Pittsburgh, Ctr Med, Cardiovasc Inst, Pittsburgh, PA 15213 USA. [Bittner, Vera; Rogers, William] Univ Alabama, Dept Med, Div Cardiovasc Dis, Birmingham, AL 35294 USA. RP Shaw, LJ (reprint author), Univ Pittsburgh, WISE Coordinating Ctr, Grad Sch Publ Hlth, 127 Parran Hall,130 DeSoto St, Pittsburgh, PA 15261 USA. EM lshaw3@emory.edu RI Reis, Steven/J-3957-2014; Azziz, Ricardo/N-7229-2014 OI Azziz, Ricardo/0000-0002-3917-0483 FU NCRR NIH HHS [M01-RR00425, M01 RR000425]; NHLBI NIH HHS [N01 HV068161, N01 HV068162, N01 HV068163, N01 HV068164, N01-HV-68163, N01-HV68162, N01HV68162, N01HV68163, U01 HL064829, U01 HL064914, U01 HL064924, U01 HL64914, U01 HL64924]; PHS HHS [U0164829] NR 42 TC 274 Z9 283 U1 0 U2 6 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0021-972X J9 J CLIN ENDOCR METAB JI J. Clin. Endocrinol. Metab. PD APR PY 2008 VL 93 IS 4 BP 1276 EP 1284 DI 10.1210/jc.2007-0425 PG 9 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 284AI UT WOS:000254677200030 PM 18182456 ER PT J AU Fauci, AS AF Fauci, Anthony S. TI The ASCI, the spring meetings, and growing up in academic medicine: a personal perspective SO JOURNAL OF CLINICAL INVESTIGATION LA English DT Article AB For many young physician-scientists, the American Society for Clinical Investigation spring meetings are the backdrop to their initiation into academic medicine. Membership in the ASCI is a high honor and represents one's maturation and accomplishment in clinical research. The ASCI continues to provide this meeting forum for young investigators who aspire to emulate their idols and mentors just as I did in 1969 when I attended the spring meetings in Atlantic City for the first time. C1 NIAID, NIH, Bethesda, MD USA. RP Fauci, AS (reprint author), NIAID, NIH, Bldg 31,Room 7A-03,9000 Rockville Pike,31 Ctr Dr, Bethesda, MD USA. EM afauci@niaid.nih.gov NR 4 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC CLINICAL INVESTIGATION INC PI ANN ARBOR PA 35 RESEARCH DR, STE 300, ANN ARBOR, MI 48103 USA SN 0021-9738 J9 J CLIN INVEST JI J. Clin. Invest. PD APR PY 2008 VL 118 IS 4 BP 1214 EP 1217 DI 10.1172/JCI34724 PG 4 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 282SX UT WOS:000254588600003 PM 18382723 ER PT J AU Nabel, EG AF Nabel, Elizabeth G. TI The physician-scientist: a value proposition SO JOURNAL OF CLINICAL INVESTIGATION LA English DT Article ID GENE-EXPRESSION INVIVO; ARTERIAL-WALL AB The American Society for Clinical Investigation has supported the career development of physician-scientists for the past 100 years. As the ASCI looks to its next 100 years, it must be a leading force, not only for advancing the research of physician-scientists, but also for stimulating public advocacy for biomedical research in this country. C1 NHLBI, NIH, Bethesda, MD 20892 USA. RP Nabel, EG (reprint author), NHLBI, NIH, Bldg 31-Room 5A48, Bethesda, MD 20892 USA. EM nabele@nih.gov NR 8 TC 3 Z9 3 U1 0 U2 1 PU AMER SOC CLINICAL INVESTIGATION INC PI ANN ARBOR PA 35 RESEARCH DR, STE 300, ANN ARBOR, MI 48103 USA SN 0021-9738 J9 J CLIN INVEST JI J. Clin. Invest. PD APR PY 2008 VL 118 IS 4 BP 1233 EP 1235 DI 10.1172/JCI35074 PG 3 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 282SX UT WOS:000254588600013 PM 18382733 ER PT J AU Petri, WA Miller, M Binder, HJ Levine, MM Dillingham, R Guerrant, RL AF Petri, William A., Jr. Miller, Mark Binder, Henry J. Levine, Myron M. Dillingham, Rebecca Guerrant, Richard L. TI Enteric infections, diarrhea, and their impact on function and development SO JOURNAL OF CLINICAL INVESTIGATION LA English DT Review ID ENTEROAGGREGATIVE ESCHERICHIA-COLI; EARLY-CHILDHOOD DIARRHEA; ORAL REHYDRATION THERAPY; SHIGELLA-FLEXNERI 2A; ENTAMOEBA-HISTOLYTICA INFECTION; HELICOBACTER-PYLORI INFECTION; CATCH-UP GROWTH; RANDOMIZED CONTROLLED-TRIAL; CELLULAR IMMUNE-RESPONSES; O-SPECIFIC POLYSACCHARIDE AB Enteric infections, with or without overt diarrhea, have profound effects on intestinal absorption, nutrition, and childhood development as well as on global mortality. Oral rehydration therapy has reduced the number of deaths from dehydration caused by infection with an enteric pathogen, but it has not changed the morbidity caused by such infections. This Review focuses on the interactions between enteric pathogens and human genetic determinants that alter intestinal function and inflammation and profoundly impair human health and development. We also discuss specific implications for novel approaches to interventions that are now opened by our rapidly growing molecular understanding. C1 [Petri, William A., Jr.; Dillingham, Rebecca; Guerrant, Richard L.] Univ Virginia, Sch Med, Ctr Global Hlth, Div Infect Dis & Int Hlth, Charlottesville, VA 22908 USA. [Miller, Mark] Fogarty Int Ctr, NIH, Bethesda, MD USA. [Binder, Henry J.] Yale Univ, New Haven, CT USA. [Levine, Myron M.] Univ Maryland, Sch Med, Ctr Vaccine Dev, Baltimore, MD 21201 USA. RP Guerrant, RL (reprint author), Univ Virginia, Sch Med, Ctr Global Hlth, Div Infect Dis & Int Hlth, MRA,409 Lane Rd,Room 3148, Charlottesville, VA 22908 USA. EM guerrant@virginia.edu NR 169 TC 139 Z9 144 U1 1 U2 11 PU AMER SOC CLINICAL INVESTIGATION INC PI ANN ARBOR PA 35 RESEARCH DR, STE 300, ANN ARBOR, MI 48103 USA SN 0021-9738 J9 J CLIN INVEST JI J. Clin. Invest. PD APR PY 2008 VL 118 IS 4 BP 1277 EP 1290 DI 10.1172/JCI34005 PG 14 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 282SX UT WOS:000254588600020 PM 18382740 ER PT J AU Larochelle, A Dunbar, CE AF Larochelle, Andre Dunbar, Cynthia E. TI HOXB4 and retroviral vectors: adding fuel to the fire SO JOURNAL OF CLINICAL INVESTIGATION LA English DT Editorial Material ID SEVERE COMBINED IMMUNODEFICIENCY; HEMATOPOIETIC STEM-CELLS; ACUTE MYELOID-LEUKEMIA; BLOOD CD34(+) CELLS; GENE-THERAPY; IN-VITRO; INSERTIONAL MUTAGENESIS; DIFFERENTIATION; VIVO; OVEREXPRESSION AB The transcription factor homeobox B4 (HOXB4) is a promising agent capable of providing a growth advantage to genetically modified hematopoietic stem and progenitor cells (HSPCs). In this issue of the JCI, Zhang and colleagues overexpressed HOXB4 in HSPCs from large animals using retroviral vectors (see the related article beginning on page 1502). Two years after transplantation, most animals developed leukemia, a consequence of combined HOXB4 and deregulated protooncogene expression. These results highlight the risks of combining integrating vectors and growth-promoting genes for clinical applications. C1 [Larochelle, Andre; Dunbar, Cynthia E.] NHLBI, Mol Hematopoiesis Sect, Hematol Branch, NIH, Bethesda, MD 20892 USA. RP Dunbar, CE (reprint author), NHLBI, Mol Hematopoiesis Sect, Hematol Branch, NIH, Bldg 10CRC,Room 4-5132,10 Ctr Dr, Bethesda, MD 20892 USA. EM dunbarc@nhlbi.nih.gov NR 21 TC 4 Z9 4 U1 0 U2 0 PU AMER SOC CLINICAL INVESTIGATION INC PI ANN ARBOR PA 35 RESEARCH DR, STE 300, ANN ARBOR, MI 48103 USA SN 0021-9738 J9 J CLIN INVEST JI J. Clin. Invest. PD APR PY 2008 VL 118 IS 4 BP 1350 EP 1353 DI 10.1172/JCI35326 PG 4 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 282SX UT WOS:000254588600028 PM 18357348 ER PT J AU Carneiro, AMD Cook, EH Murphy, DL Blakely, RD AF Carneiro, Ana Marin D. Cook, Edwin H. Murphy, Dennis L. Blakely, Randy D. TI Interactions between integrin alpha IIb beta 3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans SO JOURNAL OF CLINICAL INVESTIGATION LA English DT Article ID ACTIVATED PROTEIN-KINASE; WHOLE-BLOOD SEROTONIN; MYOCARDIAL-INFARCTION; REUPTAKE INHIBITORS; SELECTIVE SEROTONIN; PROTHROMBOTIC RISK; GLYCOPROTEIN IIIA; P38 MAPK; PHOSPHORYLATION; POLYMORPHISM AB The essential contribution of the antidepressant-sensitive serotonin (5-HT) transporter SERT (which is encoded by the SLC6A4 gene) to platelet 5-HT stores suggests an important role of this transporter in platelet function. Here, using SERT-deficient mice, we have established a role for constitutive SERT expression in efficient ADP-and thrombin-triggered platelet aggregation. Additionally, using pharmacological blockers of SERT and the vesicular monoamine transporter (VMAT), we have identified a role for ongoing 5-HT release and SERT activity in efficient human platelet aggregation. We have also demonstrated that fibrinogen, an activator of integrin alpha IIb beta 3, enhances SERT activity in human platelets and that integrin alpha IIb beta 3 interacts directly with the C terminus of SERT. Consistent with these findings, knockout mice lacking integrin beta 3 displayed diminished platelet SERT activity. Conversely, HEK293 cells engineered to express human SERT and an activated form of integrin beta 3 exhibited enhanced SERT function that coincided with elevated SERT surface expression. Our results support an unsuspected role of alpha IIb beta 3/SERT associations as well as alpha IIb beta 3 activation in control of SERT activity in vivo that may have broad implications for hyperserotonemia, cardiovascular disorders, and autism. C1 [Carneiro, Ana Marin D.; Blakely, Randy D.] Vanderbilt Univ, Sch Med, Dept Pharmacol, Nashville, TN 37232 USA. [Cook, Edwin H.] Univ Illinois, Chicago, IL USA. [Murphy, Dennis L.] NIMH, Clin Sci Lab, Bethesda, MD 20892 USA. [Blakely, Randy D.] Vanderbilt Univ, Sch Med, Dept Psychiat, Nashville, TN 37212 USA. [Blakely, Randy D.] Vanderbilt Univ, Sch Med, Ctr Mol Neurosci, Nashville, TN 37212 USA. RP Blakely, RD (reprint author), Vanderbilt Univ, Sch Med, Dept Pharmacol, 7140 MRBIII, Nashville, TN 37232 USA. EM randy.blakely@vanderbilt.edu FU Intramural NIH HHS; NICHD NIH HHS [U19 HD035482, U19 HD35482]; NIDA NIH HHS [DA007390, R01 DA007390]; NIMH NIH HHS [P50 MH078028] NR 50 TC 86 Z9 87 U1 0 U2 3 PU AMER SOC CLINICAL INVESTIGATION INC PI ANN ARBOR PA 35 RESEARCH DR, STE 300, ANN ARBOR, MI 48103 USA SN 0021-9738 J9 J CLIN INVEST JI J. Clin. Invest. PD APR PY 2008 VL 118 IS 4 BP 1544 EP 1552 DI 10.1172/JCI33374 PG 9 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 282SX UT WOS:000254588600047 PM 18317590 ER PT J AU Conville, PS Brown, JM Steigerwalt, AG Brown-Elliott, BA Witebsky, FG AF Conville, Patricia S. Brown, June M. Steigerwalt, Arnold G. Brown-Elliott, Barbara A. Witebsky, Frank G. TI Nocardia wallacei sp nov and Nocardia blacklockiae sp nov., Human Pathogens and Members of the "Nocardia transvalensis Complex" SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID RESTRICTION-ENDONUCLEASE ANALYSIS; ASTEROIDES; IDENTIFICATION; GENE; RECOGNITION; STRAINS; DNA AB Nocardia isolates that share the property of in vitro amikacin resistance are grouped together by some authors in the Nocardia transvalensis complex. Our examination of 13 isolates that are amikacin resistant has revealed the existence of three distinct species. Sequence analysis of the 16S rRNA, 65-kDa heat shock protein, and secA1 genes, coupled with DNA-DNA hybridization, indicated that "N. asteroides drug pattern IV," "N. transvalensis new taxon I," and N. transvalensis sensu stricto should each be considered a distinct species. The phenotypic and molecular characteristics of the proposed new species Nocardia wallacei (N. asteroides drug pattern IV) and N. blacklockiae (N. transvalensis new taxon 1) are presented and compared with those of N. transvalensis sensu stricto. The relative genetic diversity of isolates best placed with the species N. blacklockiae is also discussed. Case studies demonstrating the pathogenicity of N. wallacei and N. blacklockiae are presented. The type strain of N. wallacei is ATCC 49873 (DSM 45136), and that of N. blacklockiae is ATCC 700035 (DSM 45135). C1 [Conville, Patricia S.; Witebsky, Frank G.] US Dept HHS, Microbiol Serv, Dept Lab Med, Warren G Magnuson Clin Ctr,NIH, Bethesda, MD 20892 USA. [Brown, June M.; Steigerwalt, Arnold G.] US Dept HHS, Bacterial Zoonoses Branch, Div Foodborne Bacterial & Mycot Dis, Natl Ctr Zoonot Vector Borne & Enter Dis,Ctr Dis, Atlanta, GA USA. [Brown-Elliott, Barbara A.] Univ Texas Tyler, Ctr Hlth, Dept Microbiol, Tyler, TX 75799 USA. RP Conville, PS (reprint author), US Dept HHS, Microbiol Serv, Dept Lab Med, Warren G Magnuson Clin Ctr,NIH, 10 Ctr Dr,MSC 1508, Bethesda, MD 20892 USA. EM pconville@nih.gov FU Intramural NIH HHS NR 25 TC 23 Z9 27 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD APR PY 2008 VL 46 IS 4 BP 1178 EP 1184 DI 10.1128/JCM.02011-07 PG 7 WC Microbiology SC Microbiology GA 286SN UT WOS:000254866400004 PM 18256227 ER PT J AU Bohnsack, JF Whiting, A Gottschalk, M Dunn, DM Weiss, R Azimi, PH Philips, JB Weisman, LE Rhoads, GG Lin, FYC AF Bohnsack, John F. Whiting, April Gottschalk, Marcelo Dunn, Diane Marie Weiss, Robert Azimi, Parvin H. Philips, Joseph B., III Weisman, Leonard E. Rhoads, George G. Lin, Feng-Ying C. TI Population structure of invasive and colonizing strains of Streptococcus agalactiae from Neonates of six US academic Centers from 1995 to 1999 SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID GROUP-B-STREPTOCOCCUS; PHYLOGENETIC LINEAGES; UNITED-STATES; DISEASE; SEROTYPE; BOVINE; IDENTIFICATION; DNA; COLONIZATION; MULTICENTER AB The purpose of this study was to describe the population structure of group B streptococci (GBS) isolated from infected and colonized neonates during a prospective active-surveillance study of early-onset disease in six centers in the United States from July 1995 to June 1999 and to examine its relationship to bovine strains of GBS. The phylogenetic lineage of each GBS isolate was determined by multilocus sequence typing, and isolates were clustered into clonal complexes (CCs) using the eBURST software program. A total of 899 neonatal GBS isolates were studied, of which 129 were associated with invasive disease. Serotype la, Ib, and V isolates were highly clonal, with 92% to 96% of serotype la, Ib, and V isolates being confined to single clonal clusters. In contrast, serotype II and III isolates were each comprised of two major clones, with 39% of serotype II and 41% of serotype III isolates in CC 17 and 41% of serotype 11 and 54% of serotype III isolates in CC 19. Further analysis demonstrates that the CC 17 serotype 11 and III GBS are closely related to a previously described "ancestral" lineage of bovine GBS. While 120 (93%) of invasive GBS were confined to the same lineages that colonized neonates, 9 (7%) of the invasive GBS isolates were from rare lineages that comprised only 2.7% of colonizing lineages. These results are consistent with those for other geographic regions that demonstrate the highly clonal nature of GBS infecting and colonizing human neonates. C1 [Bohnsack, John F.; Whiting, April] Univ Utah, Hlth Sci Ctr, Dept Pediat, Salt Lake City, UT 84132 USA. [Dunn, Diane Marie; Weiss, Robert] Univ Utah, Hlth Sci Ctr, Genome Ctr, Salt Lake City, UT 84132 USA. [Gottschalk, Marcelo] Univ Montreal, Fac Med Vet, St Hyacinthe, PQ J2S 7C6, Canada. [Azimi, Parvin H.] Childrens Hosp Med Ctr No Calif, Dept Infect Dis, Oakland, CA USA. [Philips, Joseph B., III] Univ Alabama, Birmingham, AL USA. [Weisman, Leonard E.] Baylor Coll Med, Houston, TX 77030 USA. [Rhoads, George G.] Univ Med & Dent New Jersey, Piscataway, NJ 08854 USA. [Lin, Feng-Ying C.] NICHHD, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA. RP Bohnsack, JF (reprint author), Univ Utah, Hlth Sci Ctr, Dept Pediat, 50 N Med Dr, Salt Lake City, UT 84132 USA. EM john.bohnsack@hsc.utah.edu RI Gottschalk, Marcelo/I-8116-2012 FU NICHD NIH HHS [HD-43215, HD-43217, HD-43218, HD-43219, HD-43220, HD-43214, HD-53233, R01 HD043215] NR 35 TC 59 Z9 60 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD APR PY 2008 VL 46 IS 4 BP 1285 EP 1291 DI 10.1128/JCM.02105-07 PG 7 WC Microbiology SC Microbiology GA 286SN UT WOS:000254866400020 PM 18287314 ER PT J AU Sharma, S Ray, P Gentsch, JR Glass, RI Kalra, V Bhan, MK AF Sharma, S. Ray, P. Gentsch, J. R. Glass, R. I. Kalra, V. Bhan, M. K. TI Emergence of G12 rotavirus strains in Delhi, India, in 2000 to 2007 SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID GROUP-A ROTAVIRUS; SOUTH-INDIA; MOLECULAR EPIDEMIOLOGY; PORCINE ROTAVIRUS; HIGH-FREQUENCY; P-TYPE; CHILDREN; DIARRHEA; SEROTYPE; VACCINE AB The prospect that rotavirus diarrhea in children may soon be prevented by vaccines has placed a new priority on understanding the diversity of rotavirus strains and the mechanism by which these strains evolve over time. We have characterized a total of 465 rotavirus strains collected in North India from 2000 to 2007 for G and P types by reverse transcription-PCR and sequencing. The novel G12 rotavirus strains recently detected in other countries were first detected in India in 2001 and have emerged as the predominant strains in Delhi, India, during 2005 to 2007. While the VP7 sequence was highly homologous among G12 strains isolated in Delhi, suggesting recent emergence from a common ancestor, the strains had a diverse constellation of other gene segments, demonstrating substantial reassortment. For the entire period, the common rotavirus G types G1 (26%), G2 (25%), and G9 (14%) comprised 65% of the strains, and common P types, P[4] (19%), P[6] (22%), and P[8] (35%), comprised 76% of the total P types. Of note, we detected a high percentage of unusual (17%) strains and fecal specimens with mixed (12% G and 15% P) rotavirus infections having a variety of genomic constellations. For the first time, we identified two novel rotavirus strains with unusual G/P combinations, G2P[11] and G3P[11], in patients with diarrhea. The study highlights the great diversity among rotaviruses isolated from Indian children, the opportunity for genetic reassortment between strains, and the emergence of a novel G12 strain in our country. Due to the demonstrated effect of antigenic diversity on rotavirus vaccines, it will be important to continue careful monitoring of these strains as rotavirus vaccine programs are implemented in India. C1 [Sharma, S.; Ray, P.; Kalra, V.; Bhan, M. K.] All India Inst Med Sci, Dept Pediat, New Delhi 110029, India. [Gentsch, J. R.] Ctr Dis Control & Prevent, Gastroenteritis & Resp Virus Lab Branch, Atlanta, GA USA. [Glass, R. I.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. RP Ray, P (reprint author), All India Inst Med Sci, Dept Pediat, New Delhi 110029, India. EM pratimaray@gmail.com OI Ray, Pratima/0000-0002-2182-2279 NR 56 TC 52 Z9 54 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD APR PY 2008 VL 46 IS 4 BP 1343 EP 1348 DI 10.1128/JCM.02358-07 PG 6 WC Microbiology SC Microbiology GA 286SN UT WOS:000254866400028 PM 18272705 ER PT J AU Seiwert, TY Haraf, DJ Cohen, EEW Stenson, K Witt, ME Dekker, A Kocherginsky, M Weichselbaum, RR Chen, HX Vokes, EE AF Seiwert, Tanguy Y. Haraf, Daniel J. Cohen, Ezra E. W. Stenson, Kerstin Witt, Mary Ellyn Dekker, Allison Kocherginsky, Masha Weichselbaum, Ralph R. Chen, Helen X. Vokes, Everett E. TI Phase I study of bevacizumab added to fluorouracil- and hydroxyurea-based concomitant chemoradiotherapy for poor-prognosis head and neck cancer SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID SQUAMOUS-CELL CARCINOMA; ENDOTHELIAL GROWTH-FACTOR; METASTATIC COLORECTAL-CANCER; STIMULATING FACTOR SUPPORT; FULL-DOSE REIRRADIATION; RECURRENT HEAD; ANTIANGIOGENIC THERAPY; IONIZING-RADIATION; PLUS IRINOTECAN; TUMOR RESPONSE AB Purpose We conducted a phase I dose escalation study to determine the maximum-tolerated dose (MTD) and dose-limiting toxicity (DLT) of bevacizumab, when added to the standard FHX (fluorouracil [FU], hydroxyurea [HU], radiation) chemoradiotherapy platform in poor-prognosis head and neck cancer (HNC) patients. Patients and Methods Patients with recurrent, previously radiated or poor-prognosis, treatment-naive HNC were eligible. Treatment was repeated every 14 days for seven cycles: Bevacizumab was escalated 2.5 to 10 mg/kg, FU 600 to 800 mg/m(2) (120 hours continuous infusion), and hydroxyurea from 500 to 1,000 mg (twice daily for 5 days), starting day 1. At the MTD, the cohort was expanded. Results Forty-three patients were treated. DLT was reached at level 3 (bevacizumab 5 mg/kg, FU 800 mg/m(2), HU 1,000 mg) with two grade 3 transaminase elevations and one grade 4 neutropenia, attributed to the combination of chemotherapy with bevacizumab. For level 4, chemotherapy doses were reduced (FU 600 mg/2, HU 500 mg), and bevacizumab escalation continued to 10 mg/kg. Treatment of six assessable patients resulted in one venous thrombosis; this dose level was expanded to 26 patients. Late complications included five patients with fistula formation (11.6%) and four with ulceration/tissue necrosis (9.3%). Serious toxicities (hemorrhage/thrombosis/death) were comparable to prior reirradiation reports. Median overall survival for reirradiated patients with recurrent, nonmetastatic disease was 10.3 months [95% CI, 5.6 to 13.5]; 2-year cumulative incidence of death resulting from disease was 51.7% (95% CI, 31.7 to 68.5). Conclusion Bevacizumab can be integrated with FHX chemoradiotherapy at a dose of 10 mg/m(2) every 2 weeks with decreased chemotherapy doses because of neutropenia. The regimen shows antitumor activity. Observed fistula formation/tissue necrosis may be bevacizumab related, and further investigation should proceed with careful monitoring. C1 [Vokes, Everett E.] Univ Chicago, Dept Med, Hematol Oncol Sect, Chicago, IL 60637 USA. Univ Chicago, Dept Radiat & Cellular Oncol, Chicago, IL 60637 USA. Univ Chicago, Sect Otorhinolaryngol, Dept Surg, Chicago, IL 60637 USA. Univ Chicago, Dept Hlth Studies, Chicago, IL 60637 USA. Univ Chicago, Canc Res Ctr, Chicago, IL 60637 USA. NCI, Canc Therapy Evaluat Program, Bethesda, MD 20892 USA. RP Vokes, EE (reprint author), Univ Chicago, Dept Med, Hematol Oncol Sect, 5841 S Maryland Ave,MC2115, Chicago, IL 60637 USA. EM evokes@medicine.bsd.uchicago.edu FU NCI NIH HHS [N01 CM-622201, K12 CA132783] NR 50 TC 91 Z9 95 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 330 JOHN CARLYLE ST, STE 300, ALEXANDRIA, VA 22314 USA SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD APR 1 PY 2008 VL 26 IS 10 BP 1732 EP 1741 DI 10.1200/JCO.2007.13.1706 PG 10 WC Oncology SC Oncology GA 281WY UT WOS:000254530800026 PM 18375903 ER PT J AU Grant, BF Chou, SP Goldstein, RB Huang, B Stinson, FS Saha, TD Smith, SM Dawson, DA Pulay, AJ Pickering, RP Ruan, WJ AF Grant, Bridget F. Chou, S. Patricia Goldstein, Rise B. Huang, Boji Stinson, Frederick S. Saha, Tulshi D. Smith, Sharon M. Dawson, Deborah A. Pulay, Attila J. Pickering, Roger P. Ruan, W. June TI Prevalence, correlates, disability, and comorbidity of DSM-IV borderline personality disorder: Results from the Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions SO JOURNAL OF CLINICAL PSYCHIATRY LA English DT Review ID OBSESSIVE-COMPULSIVE DISORDER; INTERVIEW SCHEDULE AUDADIS; GENERAL-POPULATION SAMPLE; PSYCHIATRIC DIAGNOSTIC MODULES; SUBSTANCE USE DISORDERS; PROSPECTIVE FOLLOW-UP; AXIS-II COMORBIDITY; UNITED-STATES; PANIC DISORDER; DRUG MODULES AB Objectives: To present nationally representative findings on prevalence, sociodemographic correlates, disability, and comorbidity of borderline personality disorder (BPD) among men and women. Method: Face-to-face interviews were conducted with 34,653 adults participating in the 2004-2005 Wave 2 National Epidermiologic Survey on Alcohol and Related Conditions. Personality disorder diagnoses were made using the Wave 2 Alcohol Use Disorder and Associated Disabilities Interview Schedule-DSM-IV Version. Results: Prevalence of lifetime BPD was 5.9% (99% CI = 5.4 to 6.4). There were no differences in the rates of BPD among men (5.6%, 99% CI = 5.0 to 6.2) and women (6.2%, 99% CI = 5.6 to 6.9). BPD was more prevalent among Native American men, younger and separated/divorced/widowed adults, and those with lower incomes and education and was less prevalent among Hispanic men and women and Asian women. BPD was associated with substantial mental and physical disability, especially among women. High co-occurrence rates of mood and anxiety disorders with BPD were similar. With additional comorbidity controlled for, associations with bipolar disorder and schizotypal and narcissistic personality disorders remained strong and significant (odds ratios >= 4.3). Associations of BPD with other specific disorders were no longer significant or were considerably weakened. Conclusions: BPD is much more prevalent in the general population than previously recognized, is equally prevalent among men and women, and is associated with considerable mental and physical disability, especially among women. Unique and common factors may differentially contribute to disorder-specific comorbidity with BPD, and some of these associations appear to be sex-specific. There is a need for future epidemiologic, clinical, and genetically informed studies to identify unique and common factors that underlie disorder-specific comorbidity with BPD. Important sex differences observed in rates of BPD and associations with BPD can inform more focused, hypothesis-driven investigations of these factors. C1 [Grant, Bridget F.; Chou, S. Patricia; Goldstein, Rise B.; Huang, Boji; Stinson, Frederick S.; Saha, Tulshi D.; Smith, Sharon M.; Dawson, Deborah A.; Pulay, Attila J.; Pickering, Roger P.; Ruan, W. June] NIAAA, Lab Epidemiol & Biometry, Div Intramural Clin & Biol Res, NIH, Bethesda, MD 20892 USA. RP Grant, BF (reprint author), NIAAA, Lab Epidemiol & Biometry, Div Intramural Clin & Biol Res, NIH, Room 3077,MS 9304,5635 Fishers Lane, Bethesda, MD 20892 USA. EM bgrant@willco.niaaa.nih.gov RI Pulay, Attila/B-6155-2011; OI Goldstein, Rise/0000-0002-9603-9473 FU Intramural NIH HHS [Z01 AA000449-04, Z99 AA999999] NR 101 TC 454 Z9 457 U1 8 U2 78 PU PHYSICIANS POSTGRADUATE PRESS PI MEMPHIS PA P O BOX 240008, MEMPHIS, TN 38124 USA SN 0160-6689 J9 J CLIN PSYCHIAT JI J. Clin. Psychiatry PD APR PY 2008 VL 69 IS 4 BP 533 EP 545 PG 14 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA 291RT UT WOS:000255215200004 PM 18426259 ER PT J AU Klimes-Dougan, B Lee, CYS Ronsaville, D Martinez, P AF Klimes-Dougan, Bonnie Lee, Chih-Yuan S. Ronsaville, Donna Martinez, Pedro TI Suicidal risk in young adult offspring of mothers with bipolar or major depressive disorder: A longitudinal family risk study SO JOURNAL OF CLINICAL PSYCHOLOGY LA English DT Article DE suicide; bipolar; major depressive disorder; family risk; early adulthood ID CHILDREN; PARENTS; PREVALENCE; BEHAVIOR; PSYCHOPATHOLOGY; IDEATION; ADOLESCENCE; POPULATION; DISABILITY; ECA AB Recent evidence has highlighted suicidal risk associated with bipolar disorder (BD). Using a family risk approach, the goal of this study was to evaluate suicidal thoughts and behaviors longitudinally from childhood to young adulthood in children of mothers with BD, Major depressive disorder (MDD), and well mothers. Few group differences were found for cross-sectional assessments of suicidal thoughts and behavior in young adulthood; the offspring of MDD demonstrate an earlier onset and more persistent suicidality than other groups, but by young adulthood, BD offspring appear to be comparable to MDD offspring in their rates of suicidality. The longitudinal assessments reveal a pattern of higher suicidal risk in MDD offspring, more intermediate risk in BD offspring, and lower risk in well offspring. Precursors and correlates of suicidal thoughts and behaviors were also examined. These findings suggest diverse developmental trajectories based on family risk and have implications for planning preventive intervention. (C) 2008 Wiley Periodicals, Inc. C1 [Klimes-Dougan, Bonnie; Lee, Chih-Yuan S.] Univ Minnesota, Dept Psychiat, Div Cchild Adolescent Psychiat, Minneapolis, MN 55455 USA. [Ronsaville, Donna; Martinez, Pedro] NIH, NIMH, DHHS, Bethesda, MD USA. RP Klimes-Dougan, B (reprint author), Univ Minnesota, Dept Psychiat, Div Cchild Adolescent Psychiat, Minneapolis, MN 55455 USA. EM klimes@umn.edu NR 36 TC 12 Z9 12 U1 0 U2 1 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0021-9762 J9 J CLIN PSYCHOL JI J. Clin. Psychol. PD APR PY 2008 VL 64 IS 4 BP 531 EP 540 DI 10.1002/jclp.20468 PG 10 WC Psychology, Clinical SC Psychology GA 283KA UT WOS:000254633900012 PM 18357577 ER PT J AU Cha, J Kwak, T Butmarc, J Kim, TA Yufit, T Carson, P Kim, SJ Falanga, V AF Cha, Jisun Kwak, Taehee Butmarc, Janet Kim, Tae-Aug Yufit, Tatyana Carson, Polly Kim, Seong-Jin Falanga, Vincent TI Fibroblasts from non-healing human chronic wounds show decreased expression of beta ig-h3, a TGF-beta inducible protein SO JOURNAL OF DERMATOLOGICAL SCIENCE LA English DT Article DE wound healing; TGF-beta; big-h3; chronic wounds; fibroblasts ID GROWTH-FACTOR-BETA; CONTROL PRIMER SYSTEM; EXTRACELLULAR-MATRIX; DERMAL FIBROBLASTS; CELL ATTACHMENT; IN-VITRO; INTEGRIN; IDENTIFICATION; TISSUES; MICE AB Background: Increasing evidence shows persistent phenotypic alterations in fibroblasts from non-healing human chronic wounds, which may result in faulty extracellular matrix deposition and keratinocyte migration. We have previously shown that these cells are characterized by morphological changes, tow proliferative potential and unresponsiveness to TGF-beta 1, and down regulated phosphorylation of Smad 2/3 and p42/44 MAPK from decreased expression of the TGF-beta type II receptor. Objective: To identify genes and proteins that may be differentially expressed in chronic wounds and their cultured fibroblasts. Methods: Differential display analysis with 120 random primer sets was used in fibroblasts from human venous ulcers and acute wounds created on the ipsilateral thighs of the same patients. Positive differential results were confirmed by RT-PCR. Immunohistochemistry of cultured fibroblasts and tissues was used to determine the expression of differentially expressed proteins. Results: A total of 16 differentially expressed genes were identified and cloned. The only candidate gene that was differentially expressed in all patients and confirmed by repeated differential. display testing and RT-PCR was beta ig-h3, a TGF-beta-induced gene involved in cell adhesion, migration, and proliferation. Decreased expression of beta ig-h3 in chronic wounds and their fibroblasts was further confirmed by Western blot and immunostaining. Conclusion: These findings point to beta ig-h3 as an important gene characterizing the abnormal phenotype of chronic wound fibroblasts. Corrective measures to increase the expression of this protein might have therapeutic potential. (C) 2007 Published by Elsevier Ireland Ltd on behalf of Japanese Society for Investigative Dermatology. C1 [Cha, Jisun; Kwak, Taehee; Butmarc, Janet; Yufit, Tatyana; Carson, Polly; Falanga, Vincent] Roger Williams Med Ctr, Dept Dermatol & Skin Surg, Providence, RI 02908 USA. [Kwak, Taehee; Kim, Tae-Aug; Kim, Seong-Jin] NCI, NIH, Bethesda, MD 20892 USA. [Kwak, Taehee; Yufit, Tatyana; Falanga, Vincent] NIH Funded Ctr Biomed Res COBRE, Roger Williams Med Ctr, Providence, RI 02908 USA. [Falanga, Vincent] Boston Univ, Dept Dermatol, Boston, MA 02215 USA. [Falanga, Vincent] Boston Univ, Dept Biochem, Boston, MA 02215 USA. RP Falanga, V (reprint author), Roger Williams Med Ctr, Dept Dermatol & Skin Surg, 50 Maude St, Providence, RI 02908 USA. EM vfalanga@bu.edu FU NCRR NIH HHS [P20RR018757]; NIDDK NIH HHS [DK067836] NR 32 TC 18 Z9 18 U1 2 U2 7 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0923-1811 J9 J DERMATOL SCI JI J. Dermatol. Sci. PD APR PY 2008 VL 50 IS 1 BP 15 EP 23 DI 10.1016/j.jdermsci.2007.10.010 PG 9 WC Dermatology SC Dermatology GA 272QG UT WOS:000253873900002 PM 18078741 ER PT J AU Kravitz, DJ Behrmann, M AF Kravitz, Dwight Jacob Behrmann, Marlene TI The space of an object: Object attention alters the spatial gradient in the surround SO JOURNAL OF EXPERIMENTAL PSYCHOLOGY-HUMAN PERCEPTION AND PERFORMANCE LA English DT Article DE object-based attention; spatial attention; attentional gradients; visual perception ID HUMAN VISUAL-CORTEX; NEURAL MECHANISMS; GROUPED ARRAYS; SELECTION; LOCATIONS; REPRESENTATIONS; INVARIANCE; SEARCH; LOCALIZATION; INHIBITION AB Although object-based attention enhances perceptual processing of information appearing within the boundaries of a selected object, little is known about the consequences for information in the object's surround. The authors show that distance from an attended object's center of mass determines reaction time (RT) to targets in the surround. Of 2 targets in the surround, both equidistant from a cue, the target closer to the center of mass was detected faster. Moreover, RT was shown to be a linear function of distance from the center of mass of a fixed, attended object, and changes to the shape of the object and its center of mass predictably altered RT. Object-based attention leads to a pattern of facilitation in the surround that may contribute to the organization of visual scenes. C1 [Kravitz, Dwight Jacob; Behrmann, Marlene] Carnegie Mellon Univ, Dept Psychol, Pittsburgh, PA 15213 USA. [Kravitz, Dwight Jacob; Behrmann, Marlene] Ctr Neural Basis Cognit, Pittsburgh, PA USA. RP Kravitz, DJ (reprint author), NIMH, Lab Brain & Cognit, Unit Learning & Plast, NIH, 10 Ctr Dr,Room 3N228, Bethesda, MD 20892 USA. EM kravitz@mail.nih.gov RI Kravitz, Dwight/B-8430-2012; OI Behrmann, Marlene/0000-0002-3814-1015 FU PHS HHS [54246] NR 67 TC 22 Z9 22 U1 1 U2 7 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0096-1523 J9 J EXP PSYCHOL HUMAN JI J. Exp. Psychol.-Hum. Percept. Perform. PD APR PY 2008 VL 34 IS 2 BP 298 EP 309 DI 10.1037/0096-1523.34.2.298 PG 12 WC Psychology; Psychology, Experimental SC Psychology GA 277JQ UT WOS:000254208900004 PM 18377172 ER PT J AU Kawai, T Choi, U Liu, PC Lantz, LM Malech, HL AF Kawai, Toshinao Choi, Uimook Liu, Po-Ching Lantz, Larry M. Malech, Harry L. TI Transient expression of whim-associated mutant CXCR4 by transduced human hematopoietic stem cells enhances the engraftment in nod/scid mice xenograft model SO JOURNAL OF GENE MEDICINE LA English DT Meeting Abstract CT 13th Annual Meeting of the Japan-Society-of-Gene-Therapy CY JUN 28-30, 2007 CL Nagoya, JAPAN SP Japan Soc Gene Therapy C1 [Kawai, Toshinao; Choi, Uimook; Liu, Po-Ching; Malech, Harry L.] NIAID, Host Def Lab, NIH, Bethesda, MD 20892 USA. [Lantz, Larry M.] NIAID, Res Technol Branch, NIH, Bethesda, MD 20892 USA. [Kawai, Toshinao] Jikei Univ, Sch Med, Inst DNA Med, Dept Gene Therapy, Tokyo, Japan. NR 0 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 1099-498X J9 J GENE MED JI J. Gene. Med. PD APR PY 2008 VL 10 IS 4 BP 443 EP 443 PG 1 WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine, Research & Experimental SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research & Experimental Medicine GA 290SG UT WOS:000255141900042 ER PT J AU Rios, E Zhou, J Brum, G Launikonis, BS Stern, MD AF Rios, Eduardo Zhou, Jingsong Brum, Gustavo Launikonis, Bradley S. Stern, Michael D. TI Calcium-dependent inactivation terminates calcium release in skeletal muscle of amphibians SO JOURNAL OF GENERAL PHYSIOLOGY LA English DT Article ID SARCOPLASMIC-RETICULUM CA2+; 20 MM EGTA; RYANODINE RECEPTOR CHANNELS; CUT TWITCH FIBERS; CARDIAC-MUSCLE; FROG-MUSCLE; CALSEQUESTRIN DETERMINES; VOLTAGE-DEPENDENCE; LUMINAL CA2+; TIME-COURSE AB In skeletal muscle of amphibians, the cell-wide cytosolic release of calcium that enables contraction in response to an action potential appears to be built of Ca2+ sparks. The mechanism that rapidly terminates this release was investigated by studying the termination of Ca2+ release underlying sparks. In groups of thousands of sparks occurring spontaneously in membrane-permeabilized frog muscle cells a complex relationship was found between amplitude a and rise time T, which in sparks corresponds to the active time of the underlying Ca2+ release. This relationship included a range of T where a paradoxically decreased with increasing T. Three different methods were used to estimate Ca2+ release flux in groups of sparks of different T. Using every method, it was found that T and flux were inversely correlated, roughly inversely proportional. A simple model in which release sources were inactivated by cytosolic Ca2+ was able to explain the relationship. The predictive value of the model, evaluated by analyzing the variance of spark amplitude, was found to be high when allowance was made for the out-of-focus error contribution to the total variance. This contribution was estimated rising a theory of confocal scanning (Rios, E., N. Shirokova, W.G. Kirsch, G. Pizarro, M.D. Stern, H. Cheng, and A. Gonzalez. Biophys. J. 2001. 80:169-183), which was confirmed in the present work by simulated line scanning of simulated sparks. Considering these results and other available evidence it is concluded that Ca2+-dependent inactivation, or CDI, provides the crucial mechanism for termination of sparks and cell-wide Ca2+ release in amphibians. Given the similarities in kinetics of release termination observed in cell-averaged records of amphibian and mammalian muscle, and in spite of differences in activation mechanisms, CDI is likely to play a central role in mammals as well. Trivially, an inverse proportionality between release flux and duration, in sparks or in global release of skeletal muscle, maintains constancy of the amount of released Ca2+. C1 [Rios, Eduardo; Zhou, Jingsong] Rush Univ, Dept Physiol & Mol Biophys, Sect Cellular Signaling, Chicago, IL 60612 USA. [Stern, Michael D.] NIA, Gerontol Res Ctr, Cardiovasc Sci Lab, Baltimore, MD 21224 USA. [Launikonis, Bradley S.] Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia. [Brum, Gustavo] Univ Republica, Fac Med, Dept Biofis, Montevideo 11800, Uruguay. RP Rios, E (reprint author), Rush Univ, Dept Physiol & Mol Biophys, Sect Cellular Signaling, Chicago, IL 60612 USA. EM erios@rush.edu RI Launikonis, Bradley/K-6256-2015 FU NIAMS NIH HHS [R01 AR032808, R01 AR049184] NR 60 TC 11 Z9 11 U1 0 U2 2 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021 USA SN 0022-1295 J9 J GEN PHYSIOL JI J. Gen. Physiol. PD APR PY 2008 VL 131 IS 4 BP 335 EP 348 DI 10.1085/jgp.200709870 PG 14 WC Physiology SC Physiology GA 292ET UT WOS:000255250000005 PM 18347079 ER PT J AU Simmons, HE Holmes, EC Stephenson, AG AF Simmons, Heather E. Holmes, Edward C. Stephenson, Andrew G. TI Rapid evolutionary dynamics of zucchini yellow mosaic virus SO JOURNAL OF GENERAL VIROLOGY LA English DT Article ID RNA VIRUSES; GENETIC BOTTLENECKS; MOLECULAR ANALYSIS; COAT PROTEIN; TRANSMISSION; POTYVIRUS; VARIABILITY; POPULATIONS; ZYMV; SUBSTITUTION AB Zucchini yellow mosaic virus (ZYMV) is an economically important virus of cucurbit crops. However, little is known about the rate at which this virus has evolved within members of the family Cucurbitaceae, or the timescale of its epidemiological history. Herein, we present the first analysis of the evolutionary dynamics of ZYMV. Using a Bayesian coalescent approach we show that the coat protein of ZYMV has evolved at a mean rate of 5.0x10(-4) nucleotide substitutions per site, per year. Notably, this rate is equivalent to those observed in animal RNA viruses. Using the same approach we show that the lineages of ZYMV sampled here have an ancestry that dates back no more than 800 years, suggesting that human activities have played a central role in the dispersal of ZYMV. Finally, an analysis of phylogeographical structure provides strong evidence for the in situ evolution of ZYMV within individual countries. C1 [Simmons, Heather E.; Holmes, Edward C.; Stephenson, Andrew G.] Penn State Univ, Dept Biol, Ctr Infect Dis Dynam, University Pk, PA 16802 USA. [Holmes, Edward C.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. RP Holmes, EC (reprint author), Penn State Univ, Dept Biol, Ctr Infect Dis Dynam, University Pk, PA 16802 USA. EM ech15@psu.edu OI Holmes, Edward/0000-0001-9596-3552 NR 39 TC 32 Z9 33 U1 0 U2 5 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 0022-1317 J9 J GEN VIROL JI J. Gen. Virol. PD APR PY 2008 VL 89 BP 1081 EP 1085 DI 10.1099/vir.0.83543-0 PN 4 PG 5 WC Biotechnology & Applied Microbiology; Virology SC Biotechnology & Applied Microbiology; Virology GA 287BI UT WOS:000254890900029 PM 18343852 ER PT J AU Choi, YH Vay, SA Vadrevu, KP Soja, AJ Woo, JH Nolf, SR Sachse, GW Diskin, GS Blake, DR Blake, NJ Singh, HB Avery, MA Fried, A Pfister, L Fuelberg, HE AF Choi, Yonghoon Vay, Stephanie A. Vadrevu, Krishna P. Soja, Amber J. Woo, Jung-Hun Nolf, Scott R. Sachse, Glen W. Diskin, Glenn S. Blake, Donald R. Blake, Nicola J. Singh, Hanwant B. Avery, Melody A. Fried, Alan Pfister, Leonhard Fuelberg, Henry E. TI Characteristics of the atmospheric CO2 signal as observed over the conterminous United States during INTEX-NA SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Review ID TRACE GAS-TRANSPORT; CARBON-DIOXIDE; NORTH-AMERICA; NITROGEN DEPOSITION; ASIAN EMISSIONS; SULFUR-DIOXIDE; ATLANTIC-OCEAN; AIR-POLLUTANTS; BOREAL FORESTS; PACIFIC AB High resolution in situ measurements of atmospheric CO2 were made from the NASA DC-8 aircraft during the Intercontinental Chemical Transport Experiment-North America (INTEX-NA) campaign, part of the wider International Consortium for Atmospheric Research on Transport and Transformation (ICARTT). During the summer of 2004, eighteen flights comprising 160 h of measurements were conducted within a region bounded by 27 to 53 degrees N and 36 to 139 degrees W over an altitude range of 0.15 to 12 km. These large-scale surveys provided the opportunity to examine the characteristics of the atmospheric CO2 signal over sparsely sampled areas of North America and adjacent ocean basins. The observations showed a high degree of variability (<= 18%) due to the myriad source and sink processes influencing the air masses intercepted over the INTEX-NA sampling domain. Surface fluxes had strong effects on continental scale concentration gradients. Clear signatures of CO2 uptake were seen east of the Mississippi River, notably a persistent CO2 deficit in the lowest 2-3 km. When combining the airborne CO2 measurements with LANDSAT and MODIS data products, the lowest CO2 mixing ratios observed during the campaign (337 ppm) were tied to mid-continental agricultural fields planted in corn and soybeans. We used simultaneous measurements of CO, O-3, C2Cl4, C2H6, C2H2 and other unique chemical tracers to differentiate air mass types. Coupling these distinct air mass chemical signatures with transport history permitted identification of convection, stratosphere-troposphere exchange, long-range transport from Eastern Asia, boreal wildfires, and continental outflow as competing processes at multiple scales influencing the observed concentrations. Our results suggest these are important factors contributing to the large-scale distribution in CO2 mixing ratios thus these observations offer new constraints in the computation of the North American carbon budget. C1 [Choi, Yonghoon; Soja, Amber J.] NIA, NASA, Langley Res Ctr, Hampton, VA 23666 USA. [Woo, Jung-Hun] Konkuk Univ, Dept Adv Technol Fus, Seoul, South Korea. [Vadrevu, Krishna P.] Ohio State Univ, Ohio Agr Res & Dev Ctr, Agroecosyst Management Program, Wooster, OH 44691 USA. [Nolf, Scott R.] Comp Sci Corp, Hampton, VA USA. [Blake, Donald R.; Blake, Nicola J.] Univ Calif Irvine, Dept Chem, Irvine, CA 92717 USA. [Singh, Hanwant B.; Pfister, Leonhard] Natl Ctr Atmospher Res, Boulder, CO 80307 USA. [Fuelberg, Henry E.] Florida State Univ, Dept Meteorol, Tallahassee, FL 32306 USA. RP Choi, YH (reprint author), NIA, NASA, Langley Res Ctr, 100 Explorat Way, Hampton, VA 23666 USA. EM ychoi@nianet.org OI Vadrevu, Krishna/0000-0003-4407-5605 NR 106 TC 19 Z9 19 U1 2 U2 5 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X EI 2169-8996 J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD APR 1 PY 2008 VL 113 IS D7 AR D07301 DI 10.1029/2007JD008899 PG 16 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 284OY UT WOS:000254716900001 ER PT J AU Winkler-Pickett, R Young, HA Cherry, JM Diehl, J Wine, J Back, T Bere, WE Mason, AT Ortaldo, JR AF Winkler-Pickett, Robin Young, Howard A. Cherry, James M. Diehl, John Wine, John Back, Timothy Bere, William E. Mason, Anna T. Ortaldo, John R. TI In vivo regulation of experimental autoimmune encephalomyelitis by NK cells: Alteration of primary adaptive responses SO JOURNAL OF IMMUNOLOGY LA English DT Article ID NATURAL-KILLER-CELLS; CENTRAL-NERVOUS-SYSTEM; AUTOREACTIVE T-CELLS; INTERFERON-GAMMA; IFN-GAMMA; IMMUNE-RESPONSE; ACTIVATING LY-49D; VIRAL-INFECTION; DENDRITIC CELLS; INNATE IMMUNITY AB Innate immune responses provide the host with its first line of defense against infections. Signals generated by subsets of lymphocytes, including NK cells, NKT cells, and APC during this early host response determine the nature of downstream adaptive immune responses. In the present study, we have examined the role of innate NK cells in an autoimmune model through the use of primary immunization with the myelin oligodendrocyte glycoprotein peptide to induce experimental autoimmune encephalomyelitis (EAE). Our studies have shown that in vivo depletion of INK cells can affect the adaptive immune responses, because NK cells were found to regulate the degree of clinical paralysis and to alter immune adaptive responses to the myelin oligodendrocyte glycoprotein peptide. The requirement for NK cells was reflected by changes in the T cell responses and diminished clinical disease seen in mice treated with anti-NK1.1, anti-asialo GM1, and selected Ly49 subtype-depleted mice. In addition to alteration in T cell responses, the maturational status of dendritic cells in lymph nodes was altered both quantitatively and qualitatively. Finally, examination of TCR V beta usage of the brain lymphocytes from EAE mice indicated a spectra-type change in receptor expression in NK- depleted mice as compared with non-NK-depleted EAE mice. These findings further establish a recently postulated link between NK cells and the generation of autoreactive T cells. C1 [Winkler-Pickett, Robin; Young, Howard A.; Wine, John; Back, Timothy; Mason, Anna T.; Ortaldo, John R.] NCI, Expt Immunol Lab, Canc & Inflammat Program, Ctr Canc Res, Frederick, MD 21702 USA. [Cherry, James M.; Diehl, John] NCI, SAIC, Gene Express Lab, Frederick, MD 21702 USA. [Bere, William E.] NCI, Basic Res Lab, SAIC Frederick, Frederick, MD 21702 USA. RP Young, HA (reprint author), NCI, Expt Immunol Lab, Canc & Inflammat Program, Ctr Canc Res, 1050 Boyles St, Frederick, MD 21702 USA. EM younghow@mail.nih.gov FU Intramural NIH HHS; NCI NIH HHS [N01 CO 12400] NR 71 TC 51 Z9 53 U1 0 U2 1 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD APR 1 PY 2008 VL 180 IS 7 BP 4495 EP 4506 PG 12 WC Immunology SC Immunology GA 324GT UT WOS:000257506700020 PM 18354171 ER PT J AU Usharauli, D Kamala, T AF Usharauli, David Kamala, Tirumalai TI Brief antigenic stimulation generates effector CD8 T cells with low cytotoxic activity and high IL-2 production SO JOURNAL OF IMMUNOLOGY LA English DT Article ID PROMOTES DIFFERENTIATION; CLONAL EXPANSION; DENDRITIC CELLS; CUTTING EDGE; MEMORY CELLS; EXPRESSION; SIGNALS; TCR; INFECTION; RESPONSES AB It is currently believed that a brief antigenic stimulation is sufficient to induce CD8 T cells to complete their differentiation program, become effector T cells, and subsequently generate memory. Because this concept was derived from studies in which only a single effector function was analyzed (either IFN-gamma production or target cell lysis), we wondered whether monitoring for multiple effector functions might reveal novel characteristics of effector CD8 T cells elicited by brief or prolonged Ag exposure. Using an in vitro system to generate effector T cells and an in vivo adoptive transfer model to track donor CD8 T cells, we found that the differentiation programs acquired by CD8 T cells after brief or prolonged antigenic stimulation were different. Although the frequencies of IFN-gamma and TNF-alpha producers were comparable for both effector CD8 T cell populations, there were major differences in cytotoxic potential and IL-2 production. Whereas prolonged (> 24 h) Ag exposure stimulated effector CD8 T cells with high cytotoxic activity and low IL-2 production, brief (< 24 h) stimulation generated effector CD8 T cells with low cytotoxic activity and high IL-2 production. The latter effector T cells rapidly converted into central memory-like CD8 T cells, exhibited long-term survival in adoptively transferred hosts, and gave robust recall responses upon Ag challenge. These data suggest that not all functions of effector CD8 T cells are equally inherited after brief or prolonged antigenic stimulation. C1 [Usharauli, David; Kamala, Tirumalai] NIAID, T Cell Tolerance & Memory Sect, Ghost Lab, Cellular & Mol Immunol Lab,NIH, Bethesda, MD 20892 USA. RP Usharauli, D (reprint author), NIAID, T Cell Tolerance & Memory Sect, Ghost Lab, Cellular & Mol Immunol Lab,NIH, Bldg 4,Room 111,9000 Rockville Pike, Bethesda, MD 20892 USA. EM dusharauli@niaid.nih.gov FU Intramural NIH HHS NR 40 TC 5 Z9 5 U1 0 U2 2 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD APR 1 PY 2008 VL 180 IS 7 BP 4507 EP 4513 PG 7 WC Immunology SC Immunology GA 324GT UT WOS:000257506700021 PM 18354172 ER PT J AU Kim, MS Kuehn, HS Metcalfe, DD Gilfillan, AM AF Kim, Mi-Sun Kuehn, Hye Sun Metcalfe, Dean D. Gilfillan, Alasdair M. TI Activation and function of the mTORC1 pathway in mast cells SO JOURNAL OF IMMUNOLOGY LA English DT Article ID FC-EPSILON-RI; C-KIT; PHOSPHATIDYLINOSITOL 3-KINASE; ALLERGIC RESPONSE; PHOSPHOINOSITIDE 3-KINASE; SIGNALING PATHWAYS; IMMUNE-RESPONSES; BINDING PARTNER; GROWTH; SURVIVAL AB Little is known about the signals downstream of PI3K which regulate mast cell homeostasis and function following Fc epsilon RI aggregation and Kit ligation. In this study, we investigated the role of the mammalian target of rapamycin complex 1 (mTORC1) pathway in these responses. In human and mouse mast cells, stimulation via Fc epsilon RI or Kit resulted in a marked PI3K-dependent activation of the mTORC1 pathway, as revealed by the wortmannin-sensitive sequential phosphorylation of tuberin, mTOR, p70S6 kinase (p70S6K), and 4E-BP1. In contrast, in human tumor mast cells, the mTORC1 pathway was constitutively activated and this was associated with markedly elevated levels of mTORC1 pathway components. Rapamycin, a specific inhibitor of mTORC1, selectively and completely blocked the Fc epsilon RI- and Kit-induced mTORC1-dependent p70S6K phosphorylation and partially blocked the 4E-BP1 phosphorylation. In parallel, although rapamycin had no effect on Fc epsilon RI-mediated degranulation or Kit-mediated cell adhesion, it inhibited cytokine production, and kit-mediated chemotaxis and cell survival. Furthermore, Rapamycin also blocked the constitutive activation of the mTORC1 pathway and inhibited cell survival of tumor mast cells. These data provide evidence that mTORC1 is a point of divergency for the PI3K-regulated downstream events of Fc epsilon RI and Kit for the selective regulation of mast cell functions. Specifically, the mTORC1 pathway may play a critical role in normal and dysregulated control of mast cell homeostasis. C1 [Kim, Mi-Sun; Kuehn, Hye Sun; Metcalfe, Dean D.; Gilfillan, Alasdair M.] NIAID, Lab Allerg Dis, NIH, Bethesda, MD 20892 USA. RP Gilfillan, AM (reprint author), NIAID, Lab Allerg Dis, NIH, Bldg 10,Room 11C206,10 Ctr Dr MSC 1881, Bethesda, MD 20892 USA. EM agilfillan@niaid.nih.gov FU Intramural NIH HHS [Z01 AI000965-02] NR 49 TC 59 Z9 59 U1 2 U2 3 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD APR 1 PY 2008 VL 180 IS 7 BP 4586 EP 4595 PG 10 WC Immunology SC Immunology GA 324GT UT WOS:000257506700030 PM 18354181 ER PT J AU Hisatsune, J Nakayama, M Isomoto, H Kurazono, H Mukaida, N Mukhopadhyay, AK Azuma, T Yamaoka, Y Sap, J Yamasaki, E Yahiro, K Moss, J Hirayama, T AF Hisatsune, Junzo Nakayama, Masaaki Isomoto, Hajime Kurazono, Hisao Mukaida, Naofumi Mukhopadhyay, Asish K. Azuma, Takeshi Yamaoka, Yoshio Sap, Jan Yamasaki, Eiki Yahiro, Kinnosuke Moss, Joel Hirayama, Toshiya TI Molecular characterization of Helicobacter pylori VacA induction of IL-8 in U937 cells reveals a prominent role for p38MAPK in activating transcription factor-2, cAMP response element binding protein, and NF-kappa B activation SO JOURNAL OF IMMUNOLOGY LA English DT Article ID CAG PATHOGENICITY ISLAND; GASTRIC EPITHELIAL-CELLS; MONOCYTE CHEMOATTRACTANT PROTEIN-1; HUMAN ENDOTHELIAL-CELLS; VACUOLATING CYTOTOXIN; AZ-521 CELLS; INTERLEUKIN-8 PRODUCTION; INFLAMMATORY RESPONSE; CHEMOKINE EXPRESSION; VIRULENCE FACTORS AB Helicobacterpylori VacA induces multiple effects on susceptible cells, including vacuolation, mitochondrial damage, inhibition of cell growth, and enhanced cyclooxygenase-2 expression. To assess the ability of H. pylori to modulate the production of inflammatory mediators, we examined the mechanisms by which VacA enhanced IL-8 production by promonocytic U937 cells, which demonstrated the greatest VacA-induced IL-8 release of the cells tested. Inhibitors of p38 MAPK (SB203580), ERK1/2 (PD98059), IKBa ((E)-3-(4-methylphenyisulfonyl)-2-propenenitrile), Ca2+ entry (SKF96365), and intracellular Ca 21 channels (dantrolene) blocked VacA-induced IL-8 production. Furthermore, an intracellular Ca2+ chelator (BAPTA-AM), which inhibited VacA-activated p38 MAPK, caused a dose-dependent reduction in VacA-induced IL-8 secretion by U937 cells, implying a role for intracellular Ca 21 in mediating activation of MAPK and the canonical NF-kappa B pathway. VacA stimulated translocation of NF-kappa Bp65 to the nucleus, consistent with enhancement of IL-8 expression by activation of the NF-kappa B pathway. In addition, small interfering RNA of activating transcription factor (ATF)-2 or CREB, which is a p38MAPK substrate and binds to the AP-1 site of the IL-8 promoter, inhibited VacA-induced IL-8 production. VacA activated an IL-8 promoter containing an NF-IL-6 site, but not a mutated AP-1 or NF-kappa B site, suggesting direct involvement of the ATF-2/CREB binding region or NF-kappa B-binding regions in VacA-induced IL-8 promoter activation. Thus, in U937 cells, VacA directly increases IL-8 production by activation of the p38 MAPK via intracellular Ca2+ release, leading to activation of the transcription factors, ATF-2, CREB, and NF-kappa B. C1 [Hisatsune, Junzo; Nakayama, Masaaki; Mukhopadhyay, Asish K.; Hirayama, Toshiya] Nagasaki Univ, Dept Bacteriol, Inst Trop Med, Nagasaki 8528523, Japan. [Isomoto, Hajime] Nagasaki Univ, Dept Endoscopy, Sch Med, Nagasaki 852, Japan. [Kurazono, Hisao] Obihiro Univ Agr & Vet Med, Dept Appl Vet Med & Publ Hlth, Obihiro, Hokkaido 080, Japan. [Mukaida, Naofumi] Kanazawa Univ, Canc Res Inst, Div Mol Bioregualt, Kanazawa, Ishikawa 920, Japan. [Azuma, Takeshi] Kobe Univ, Sch Med, Dept Gastroenterol, Kobe, Hyogo 650, Japan. [Yamaoka, Yoshio] Michael E DeBakey VA Med Ctr, Dept Med Gastroenterol, Houston, TX 77030 USA. [Yamaoka, Yoshio] Baylor Coll Med, Houston, TX 77030 USA. [Sap, Jan] Univ Copenhagen, Copenhagen Bioctr Biotechnol & Innovat Ctr, Copenhagen, Denmark. [Yamasaki, Eiki; Yahiro, Kinnosuke; Moss, Joel] NHLBI, Translat Med Branch, Natl Inst Hlth, Bethesda, MD 20892 USA. RP Hirayama, T (reprint author), Nagasaki Univ, Dept Bacteriol, Inst Trop Med, Nagasaki 8528523, Japan. EM hirayama@net.nagasaki-u.ac.jp RI Mukaida, Naofumi/D-7623-2011 OI Mukaida, Naofumi/0000-0002-4193-1851 FU Intramural NIH HHS [Z01 HL000659-15] NR 63 TC 55 Z9 56 U1 0 U2 2 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD APR 1 PY 2008 VL 180 IS 7 BP 5017 EP 5027 PG 11 WC Immunology SC Immunology GA 324GT UT WOS:000257506700076 PM 18354227 ER PT J AU Mostbock, S Lutsiak, MEC Milenic, DE Baidoo, K Schlom, J Sabzevari, H AF Mostboeck, Sven Lutsiak, M. E. Christine Milenic, Diane E. Baidoo, Kwamena Schlom, Jeffrey Sabzevari, Helen TI IL-2/anti-IL-2 antibody complex enhances vaccine-mediated antigen-specific CD8(+) T cell responses and increases the ratio of effector/memory CD8(+) T cells to regulatory T cells SO JOURNAL OF IMMUNOLOGY LA English DT Article ID RECOMBINANT INTERLEUKIN-2 RIL-2; IN-VIVO; MONOCLONAL-ANTIBODY; HOMEOSTATIC PROLIFERATION; INFLUENZA NUCLEOPROTEIN; ANTITUMOR EFFICACY; IL-2; MICE; CYTOKINES; THERAPY AB IL-2 is well described as a cytokine with two markedly distinct functionalities: as a necessary signal during CD4(+) and CD8(+) T cell activation/expansion and as an essential cytokine for the maintenance of CD4(+)CD25(+)FoxP3(+) T cells (regulatory T (T-REG) cells) during homeostasis. In this study we demonstrate for the first time that, compared with the use of IL-2 alone, a complex of IL-2 and anti-IL-2 Ab (IL-2 complex) enhances the effectiveness of a viral vaccine in a mouse model with known Ag specificity. IL-2 complex led to an increase in the number of Ag-specific effector/memory CD8(+) T cells, cytokine production, and CTL lysis following Ag-specific restimulation in a vaccination setting. Our results further demonstrate that this effect is temporary and declines over the course of a few days after the IL-2 complex treatment cycle. Moreover, in contrast to the use of IL-2 alone, IL-2 complex greatly increased the ratio of effector/memory CD8(+) T cells to T-REG cells. This phenomenon can thus potentially be used in the enhancement of immune responses to vaccination. C1 [Mostboeck, Sven; Lutsiak, M. E. Christine; Schlom, Jeffrey; Sabzevari, Helen] NCI, Tumor Immunol & Biol Lab, Ctr Canc Res, Natl Inst Hlth, Bethesda, MD 20892 USA. [Milenic, Diane E.; Baidoo, Kwamena] NCI, Radioimmune & Inorgan Chem Sect, Radiat Oncol Branch, Natl Inst Hlth, Bethesda, MD 20892 USA. RP Schlom, J (reprint author), NCI, Tumor Immunol & Biol Lab, Ctr Canc Res, Natl Inst Hlth, Bldg 10,Room 8B09,10 Ctr Dr, Bethesda, MD 20892 USA. EM js141c@nih.gov FU Intramural NIH HHS NR 45 TC 28 Z9 30 U1 0 U2 1 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 EI 1550-6606 J9 J IMMUNOL JI J. Immunol. PD APR 1 PY 2008 VL 180 IS 7 BP 5118 EP 5129 PG 12 WC Immunology SC Immunology GA 324GT UT WOS:000257506700087 PM 18354238 ER PT J AU Sadun, RE Hsu, WE Zhang, N Nien, YC Bergeld, SA Sabzevari, H Lutsiak, MEC Khawli, L Hu, PS Epstein, AL AF Sadun, Rebecca E. Hsu, Wen-En Zhang, Nan Nien, Yu-Chih Bergeld, Scott A. Sabzevari, Helen Lutsiak, M. E. Christine Khawli, Leslie Hu, Peisheng Epstein, Alan L. TI Fc-mOX40L fusion protein produces complete remission and enhanced survival in 2 murine tumor models SO JOURNAL OF IMMUNOTHERAPY LA English DT Article DE Fc-mOX40L; OX40L; CD134L; antibody immunotherapy; TNFSF; fusion proteins ID EXPERIMENTAL SOLID TUMORS; T-CELL RESPONSES; OX40-OX40 LIGAND INTERACTION; OX40 LIGAND; IN-VIVO; ANTITUMOR IMMUNITY; OX-40 LIGAND; IFN-GAMMA; MEMORY; IMMUNOTHERAPY AB OX40L is a member of the tumor necrosis factor superfamily that provides a costimulatory signal to CD4(+) and CD8(+) T cells while inhibiting the effects of suppressive CD4(+)CD25(+) regulatory T cells. Because of this dual activity, OX40L may provide significant antitumor immunity in tumor-bearing mice. To study its clinical potential, a fusion protein consisting of mOX40L linked to the C-terminus of the Fc fragment of immunoglobulin was genetically engineered. After demonstrating its potency in vitro, several assays were performed to evaluate its antitumor effect in comparison to the OX40 agonist antibody OX86. Dosing studies in Colon 26-bearing and renal cell carcinoma (RENCA)-bearing mice showed that although OX86 produced modest tumor regression, Fc-mOX40L produced complete remission in both tumor models. Survival studies confirmed these results and showed that Fc-mOX40L treatment produced lasting responses throughout the 5-month observation period. Flow cytometric analysis of treated and untreated tumors and tumor-draining lymph nodes identified a qualitative difference in the activity of Fc-mOX40L compared with OX86 treatment as evidenced by differences in lymphoid and macrophage populations. These studies reflect the profound therapeutic potential of Fc-mOX40L, which substantially exceeds the agonist antibody OX86 in ability to produce complete tumor remissions and promote long-term survival in solid tumor models. C1 [Sadun, Rebecca E.; Hsu, Wen-En; Zhang, Nan; Bergeld, Scott A.; Hu, Peisheng; Epstein, Alan L.] Univ So Calif, Dept Pathol, Keck Sch Med, Los Angeles, CA 90033 USA. [Nien, Yu-Chih] Univ So Calif, Dept Microbiol, Keck Sch Med, Los Angeles, CA 90033 USA. [Khawli, Leslie] Genentech Inc, San Francisco, CA 94080 USA. [Sabzevari, Helen; Lutsiak, M. E. Christine] NCI, Tumor Immunol & Biol Lab, NIH, Bethesda, MD 20892 USA. RP Epstein, AL (reprint author), Univ So Calif, Dept Pathol, Keck Sch Med, 2011 Zonal Ave,HMR 205, Los Angeles, CA 90033 USA. EM aepstein@usc.edu NR 52 TC 20 Z9 20 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1524-9557 J9 J IMMUNOTHER JI J. Immunother. PD APR PY 2008 VL 31 IS 3 BP 235 EP 245 PG 11 WC Oncology; Immunology; Medicine, Research & Experimental SC Oncology; Immunology; Research & Experimental Medicine GA 279JC UT WOS:000254350500002 PM 18317364 ER PT J AU Morris, JC Waldmann, TA Janik, JE AF Morris, John C. Waldmann, Thomas A. Janik, John E. TI Receptor-directed and lymphomas therapy of T-cell leukemias and lymphomas SO JOURNAL OF IMMUNOTOXICOLOGY LA English DT Review DE antibody; leukemia; lymphoma; receptor; T-cell ID NON-HODGKINS-LYMPHOMA; ANTI-CD52 MONOCLONAL-ANTIBODY; ACUTE LYMPHOBLASTIC-LEUKEMIA; REED-STERNBERG CELLS; A-CHAIN IMMUNOTOXIN; PHASE-I TRIAL; IL-2 RECEPTOR; MURINE MODEL; BETA-CHAIN; HUMANIZED ANTIBODY AB T-Cell leukemias and lymphomas represent a less common and heterogeneous group of lymphoid neoplasms. Overall, they respond less well to chemotherapy and have a poorer prognosis than their B-cell counterparts. T-Cell tumors express a number of potential targets for receptor-directed antibody therapy; however, there is no available therapeutic monoclonal antibody for these diseases with comparable activity to that of rituximab in B-cell disorders. Despite this, alemtuzumab, a humanized anti-CD52 monoclonal antibody has demonstrated meaningful anti-tumor activity in a variety of T-cell malignancies. A number of other antibodies, modified antibodies and immunotoxins directed against targets such as CD2, CD4, CD5, CD25, CD30 and CD122 expressed on malignant T-cells are under investigation. The current status of receptor-directed antibody therapy for T-cell leukemia and lymphoma is reviewed. C1 [Morris, John C.; Waldmann, Thomas A.; Janik, John E.] Natl Canc Inst, Mark O Hatfield Clin Res Ctr, Ctr Canc Res, Metab Branch, Bethesda, MD 20892 USA. RP Morris, JC (reprint author), Natl Canc Inst, Mark O Hatfield Clin Res Ctr, Ctr Canc Res, Metab Branch, Room 4-5330,10 Ctr Dr, Bethesda, MD 20892 USA. EM jmorris@mail.nih.gov NR 135 TC 17 Z9 19 U1 1 U2 2 PU INFORMA HEALTHCARE PI NEW YORK PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA SN 1547-691X EI 1547-6901 J9 J IMMUNOTOXICOL JI J. Immunotoxicol. PD APR-JUN PY 2008 VL 5 IS 2 BP 235 EP 248 DI 10.1080/15476910802129661 PG 14 WC Toxicology SC Toxicology GA 321UM UT WOS:000257332000019 PM 18569395 ER PT J AU Brenner, M Coelho, SG Beer, JZ Miller, SA Hearing, VJ AF Brenner, M. Coelho, S. G. Beer, J. Z. Miller, S. A. Hearing, V. J. TI Persistent molecular changes after repetitive in situ UV exposure of human skin SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Brenner, M.] Univ Munich, Dept Dermatol, D-8000 Munich, Germany. [Coelho, S. G.; Hearing, V. J.] NCI, Cell Biol Lab, NIH, Bethesda, MD 20892 USA. [Beer, J. Z.; Miller, S. A.] US FDA, Ctr Devices & Radiol Hlth, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 MA 1270 BP S212 EP S212 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353801266 ER PT J AU Cataisson, C Pearson, A Michalowska, A Patel, G Yuspa, S AF Cataisson, C. Pearson, A. Michalowska, A. Patel, G. Yuspa, S. TI Defining PKC alpha transcriptome in transgenic keratinocytes reveals unique signatures for downstream signaling in the AP-1 and NF-kappa B pathways SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Cataisson, C.; Pearson, A.; Michalowska, A.; Patel, G.; Yuspa, S.] NCI, Lab Canc Biol & Genet, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 MA 802 BP S134 EP S134 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353800799 ER PT J AU Cho, Y Miyagawa, F Gutermuth, I Udey, MC Katz, SI AF Cho, Y. Miyagawa, F. Gutermuth, I. Udey, M. C. Katz, S. I. TI Expression of self-antigens on hone marrow-derived dendritic cells induce peripheral tolerance to self-antigen-specific TCR-transgenic CD8(+) T cells SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Cho, Y.; Miyagawa, F.; Gutermuth, I.; Udey, M. C.; Katz, S. I.] NCI, NIH, CCR, Dermatol Branch, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 MA 1031 BP S172 EP S172 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353801024 ER PT J AU Farasat, S Wei, MH Liewehr, DJ Steinberg, SM Bale, SJ Fleckman, P Toro, JR AF Farasat, S. Wei, M. H. Liewehr, D. J. Steinberg, S. M. Bale, S. J. Fleckman, P. Toro, J. R. TI Transglutaminase-1 gene mutations in autosomal recessive congenital ichthyosis: clinical anti genetic investigations in a large cohort of 108 patients SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Farasat, S.; Wei, M. H.; Liewehr, D. J.; Steinberg, S. M.; Toro, J. R.] NIH, Bethesda, MD 20892 USA. [Bale, S. J.] GeneDx Inc, Gaithersburg, MD USA. [Fleckman, P.] Univ Washington, Seattle, WA 98195 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 MA 666 BP S111 EP S111 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353800662 ER PT J AU Fargnoli, M Pike, K Pfeiffer, RM Tsang, S Rozenblum, E Munroe, DJ Golubeva, Y Calista, D Seidenari, S Massi, D Carli, P Bauer, J Elder, DE Bastian, BC Peris, K Landi, M AF Fargnoli, M. Pike, K. Pfeiffer, R. M. Tsang, S. Rozenblum, E. Munroe, D. J. Golubeva, Y. Calista, D. Seidenari, S. Massi, D. Carli, P. Bauer, J. Elder, D. E. Bastian, B. C. Peris, K. Landi, M. TI MC1R variants increase risk of melanomas harboring BRAF mutations SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Fargnoli, M.; Pfeiffer, R. M.; Peris, K.] Univ LAquila, Laquila, 94143, Italy. [Pike, K.; Tsang, S.; Rozenblum, E.; Munroe, D. J.] NCI, SAIC Frederick, Lab Mol Technol, Frederick, MD 19104 USA. [Landi, M.] NCI, Div Canc Epidemiol & Genet, Bethesda, MD USA. [Golubeva, Y.] NCI, SAIC Frederick, Pathol Histotechnol Lab, Frederick, MD USA. [Calista, D.] Bufalini Hosp, Cesena, Italy. [Seidenari, S.] Univ Modena & Reggio Emilia, Modena, Italy. [Massi, D.; Carli, P.] Univ Florence, Florence, Italy. [Bauer, J.; Bastian, B. C.] Univ Calif San Francisco, San Francisco, CA USA. [Elder, D. E.] Univ Penn, Philadelphia, PA USA. RI Pfeiffer, Ruth /F-4748-2011 NR 0 TC 2 Z9 2 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 BP S31 EP S31 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353800181 ER PT J AU Grice, FA Kong, HH Renaud, G Young, AC Program, N Bouffard, GG Blakesley, RW Wolfsberg, TG Tumer, ML Segre, JA AF Grice, F. A. Kong, H. H. Renaud, G. Young, A. C. Program, N. Bouffard, G. G. Blakesley, R. W. Wolfsberg, T. G. Tumer, M. L. Segre, J. A. TI Genomic analysis of the cutaneous skin microflora SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Grice, F. A.; Segre, J. A.] NHGRI, Genet & Mol Biol Branch, Natl Inst Hlth, Bethesda, MD 20892 USA. [Kong, H. H.; Tumer, M. L.] NCI, Dermatol Branch, Natl Inst Hlth, Bethesda, MD 20892 USA. [Bouffard, G. G.; Blakesley, R. W.; Wolfsberg, T. G.] NHGRI, Genome Technol Branch, Natl Inst Hlth, Bethesda, MD 20892 USA. [Young, A. C.; Program, N.; Bouffard, G. G.; Blakesley, R. W.] NHGRI, NIH Intramural Sequencing Ctr, Natl Inst Hlth, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 1 U2 3 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 MA 721 BP S121 EP S121 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353800717 ER PT J AU Gutermuth, L Nograles, K Miyagawa, F Cho, Y Katz, S AF Gutermuth, L. Nograles, K. Miyagawa, F. Cho, Yh Katz, Sl TI Self-peptide administration attenuates the course of disease in a mouse model of autoimmunity SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Gutermuth, L.; Nograles, K.; Miyagawa, F.; Cho, Yh; Katz, Sl] NCI, CCR, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 MA 77 BP S13 EP S13 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353800076 ER PT J AU Hastings, KT Irvine, KR Antony, PA Restifo, NP Cresswell, P AF Hastings, K. T. Irvine, K. R. Antony, P. A. Restifo, N. P. Cresswell, P. TI Lysosomal thiol reductase GILT is essential for MHC class II-restricted processing of melanoma antigen TRP-1 SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Hastings, K. T.] Univ Arizona, Coll Med, Phoenix, AZ USA. [Irvine, K. R.; Restifo, N. P.] NCI, Surg Branch, Bethesda, MD 20892 USA. [Antony, P. A.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Cresswell, P.] Yale Univ, Sch Med, New Haven, CT USA. RI Restifo, Nicholas/A-5713-2008 NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 MA 1120 BP S187 EP S187 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353801116 ER PT J AU Hoashi, T Muller, J Tamaki, K Ohara, K Hearing, VJ AF Hoashi, T. Muller, J. Tamaki, K. Ohara, K. Hearing, V. J. TI The internal repeat domain of the melanosomal matrix protein PMEL17/GP100 is required for fibrillogenesis SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Hoashi, T.; Tamaki, K.] Univ Tokyo, Fac Med, Dept Dermatol, Tokyo 113, Japan. [Hoashi, T.; Hearing, V. J.] NCI, Cell Biol Lab, NIH, Bethesda, MD 20892 USA. [Hoashi, T.; Ohara, K.] Toranomon Gen Hosp, Dept Dermatol, Tokyo, Japan. [Muller, J.] US FDA, Div Viral Prod, Rockville, MD 20857 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 MA 1327 BP S222 EP S222 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353801322 ER PT J AU Hwang, H Diwakar, G Jiang, S Michalowska, A Zaidi, R Merlino, G Hornyak, T AF Hwang, H. Diwakar, G. Jiang, S. Michalowska, A. Zaidi, R. Merlino, G. Hornyak, T. TI Characterization of melanocyte label-retaining cells (LRCs) by microarray analysis SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Hwang, H.; Diwakar, G.; Jiang, S.; Hornyak, T.] NCI, Dermatol Branch, Canc Res Ctr, Bethesda, MD 20892 USA. [Michalowska, A.; Zaidi, R.; Merlino, G.] NCI, Lab Canc Biol & Genet, Canc Res Ctr, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 MA 1341 BP S224 EP S224 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353801335 ER PT J AU Imoto, K Nadem, C Moriwaki, S Nishigori, C Oh, K Khan, SG Goldstein, AM Kraemer, KH AF Imoto, K. Nadem, C. Moriwaki, S. Nishigori, C. Oh, K. Khan, S. G. Goldstein, A. M. Kraemer, K. H. TI Ancient origin of a Japanese xeroderma pigmentosum founder mutation SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Imoto, K.; Nadem, C.; Oh, K.; Khan, S. G.; Goldstein, A. M.; Kraemer, K. H.] NCI, Natl Inst Hlth, Bethesda, MD 20892 USA. [Imoto, K.] Nara Med Univ, Nara, Japan. [Moriwaki, S.] Osaka Med Coll, Osaka, Japan. [Nishigori, C.] Kobe Univ, Kobe, Hyogo, Japan. NR 0 TC 1 Z9 1 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 BP S28 EP S28 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353800167 ER PT J AU King, KE Ponnamperuma, RM Allen, C Chen, Z Van Waes, C Weinberg, WC AF King, K. E. Ponnamperuma, R. M. Allen, C. Chen, Z. Van Waes, C. Weinberg, W. C. TI Delta Np63 alpha modulates keratinocyte growth regulation via activation of NF-kappa B/c-Rel SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [King, K. E.; Ponnamperuma, R. M.; Weinberg, W. C.] US FDA, CDER, Off Biotechnol Prod, Bethesda, MD 20014 USA. [Allen, C.; Chen, Z.; Van Waes, C.] NIDCD, Head & Neck Surg Branch, NIH, Bethesda, MD USA. RI Weinberg, Wendy/A-8920-2009 NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 MA 202 BP S34 EP S34 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353800203 ER PT J AU Kong, HH Azad, NS Aragon-Ching, JB Gutierrez, M Dahut, WL Kohn, EC Turner, ML AF Kong, H. H. Azad, N. S. Aragon-Ching, J. B. Gutierrez, M. Dahut, W. L. Kohn, E. C. Turner, M. L. TI Spectrum of soraienib-induced dermatologic adverse effects SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Kong, H. H.; Turner, M. L.] NCI, NIH, Dermatol Branch, Bethesda, MD 20892 USA. [Azad, N. S.; Aragon-Ching, J. B.; Gutierrez, M.; Dahut, W. L.; Kohn, E. C.] NCI, NIH, Med Oncol Branch, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 MA 465 BP S78 EP S78 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353800460 ER PT J AU Kwak, T Yufit, T Butmarc, I Carson, P Panuncialman, I Kim, S Falanga, V AF Kwak, T. Yufit, T. Butmarc, I. Carson, P. Panuncialman, I. Kim, S. Falanga, V. TI Generation of transgenic mice that inducibly express beta IG-H3 in the epidermis SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Kwak, T.; Yufit, T.; Butmarc, I.; Carson, P.; Panuncialman, I.; Falanga, V.] Roger Williams Med Ctr, Dept Dermatol & Skin Surg, Providence, RI USA. [Kwak, T.; Yufit, T.; Carson, P.; Falanga, V.] Roger Williams Med Ctr, COBRE, Providence, RI USA. [Falanga, V.] Boston Univ, Dept Dermatol & Biochem, Boston, MA 02215 USA. [Kim, S.] NIH, Lab Canc Biol & Genet, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 MA 599 BP S100 EP S100 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353800593 ER PT J AU Leitner, WW Baker, MC Lu, M Dejesus, GL Yannie, PJ Utley, MC AF Leitner, W. W. Baker, M. C. Lu, M. Dejesus, G. L. Yannie, P. J. Utley, M. C. TI Enhancement of DNA vaccine induced protection against lymphoma using limiting amounts of helper plasmid-encoded antigen SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Leitner, W. W.; Baker, M. C.; Lu, M.; Dejesus, G. L.; Yannie, P. J.; Utley, M. C.] NCI, Dermatol Branch, NIH, Bethesda, MD 20892 USA. RI Leitner, Wolfgang/F-5741-2011 OI Leitner, Wolfgang/0000-0003-3125-5922 NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 MA 1033 BP S173 EP S173 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353801028 ER PT J AU Li, L Shukla, S Yuspa, SH AF Li, L. Shukla, S. Yuspa, S. H. TI The skin tumor chemotherapeutic agent PEP005 is a substrate for the multidrug resistance protein MDR1 and damages tumor vascularity SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Li, L.; Shukla, S.; Yuspa, S. H.] NCI, LCBG, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 MA 440 BP S74 EP S74 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353800439 ER PT J AU Li, S Wang, J Rajesh, S Moss, J Darling, TN AF Li, S. Wang, J. Rajesh, S. Moss, J. Darling, T. N. TI A xenograft model replicates features of skin tumors in tuberous sclerosis complex SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Li, S.; Wang, J.; Rajesh, S.; Darling, T. N.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Moss, J.] NHLBI, Translat Med Branch, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 MA 706 BP S118 EP S118 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353800703 ER PT J AU Lonsdorf, A Hedrick, M Shirakawa, A Farber, J Hwang, ST AF Lonsdorf, A. S. Hedrick, M. N. Shirakawa, A. Farber, J. M. Hwang, S. T. TI CC chemokine receptor-6 (CCR6) is essential for IL-23-mediated psoriasiform dermatitis in a murine model of psoriasis SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Lonsdorf, A. S.; Hwang, S. T.] NCI, Dept Dermatol, NIH, Bethesda, MD 20892 USA. [Hedrick, M. N.; Shirakawa, A.; Farber, J. M.] NIAID, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 MA 62 BP S11 EP S11 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353800065 ER PT J AU Mahindra, P Faghri, S DiGiovanna, JJ Tamura, D Kraemer, KH AF Mahindra, P. Faghri, S. DiGiovanna, J. J. Tamura, D. Kraemer, K. H. TI Trichothiodystrophy: A multisystem genetic disease with striking phenotypic diversity SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Mahindra, P.; Faghri, S.; DiGiovanna, J. J.; Tamura, D.; Kraemer, K. H.] NCI, BRL, Bethesda, MD 20892 USA. [Mahindra, P.] Suny Downstate Med Sch, Brooklyn, NY USA. [DiGiovanna, J. J.] Brown Univ, Sch Med, Providence, RI 02912 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 MA 873 BP S146 EP S146 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353800868 ER PT J AU Mascia, F Cataisson, C Chandrasekhara, C Girolomoni, G Mariani, V Yuspa, SH Pastore, S AF Mascia, F. Cataisson, C. Chandrasekhara, C. Girolomoni, G. Mariani, V. Yuspa, S. H. Pastore, S. TI EGFR regulates keratinocytes GM-CSF expression in vitro and in vivo: updates on the role of EGFR in skin immune regulation SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Mascia, F.; Cataisson, C.; Chandrasekhara, C.; Yuspa, S. H.] NCI, NIH, Lab Canc Biol & Genet, Bethesda, MD 20892 USA. [Girolomoni, G.] Univ Verona, Dept Biomed & Surg Sci, I-37100 Verona, Italy. [Mariani, V.; Pastore, S.] Ist Dermopatico Immacolata, Lab Cutaneous Physiopathol, Rome, Italy. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 MA 803 BP S134 EP S134 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353800797 ER PT J AU Miyagawa, F Tagaya, Y Katz, SI AF Miyagawa, F. Tagaya, Y. Katz, S. I. TI IL-15 is a critical costimulator in determining the activity of autoreactive CD8 T cells SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Miyagawa, F.; Katz, S. I.] NCI, Dermatol Branch, NIH, Bethesda, MD 20892 USA. [Tagaya, Y.] NCI, Metab Branch, CCR, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 MA 1035 BP S173 EP S173 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353801029 ER PT J AU Morasso, MI Hwang, J Millar, SE Mehrani, T AF Morasso, M. I. Hwang, J. Millar, S. E. Mehrani, T. TI The role of DIx3 in hair development SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Morasso, M. I.; Hwang, J.; Mehrani, T.] NIAMS, NIH, Dev Skin Biol Unit, Bethesda, MD USA. [Millar, S. E.] Univ Penn, Sch Med, Dept Dermatol & Cell Dev Biol, Philadelphia, PA 19104 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 MA 920 BP S154 EP S154 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353800917 ER PT J AU Nagao, K Ginhoux, F Clausen, BE Merad, M Udey, MC AF Nagao, K. Ginhoux, F. Clausen, B. E. Merad, M. Udey, M. C. TI Differential EpCAM expression and growth factor requirements reveal heterogeneity of dendritic cells in murine skin SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Nagao, K.; Udey, M. C.] NCI, Dermatol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. [Ginhoux, F.; Merad, M.] Mt Sinai Sch Med, Depg Gene & Cell Med, New York, NY USA. [Ginhoux, F.; Merad, M.] Mt Sinai Sch Med, Dept Med, New York, NY USA. [Clausen, B. E.] Univ Amsterdam, Acad Med Ctr, Dept Cell Biol & Histol, NL-1105 AZ Amsterdam, Netherlands. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 MA 1034 BP S173 EP S173 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353801031 ER PT J AU Patel, AR Turner, ML Pavletic, SZ Cowen, EW AF Patel, A. R. Turner, M. L. Pavletic, S. Z. Cowen, E. W. TI The isomorphic response in sclerotic-type chronic graft-versus-host disease SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Patel, A. R.; Turner, M. L.; Cowen, E. W.] NCI, NIH, CCR, Dermatol Branch, Bethesda, MD 20892 USA. [Pavletic, S. Z.] NCI, NIH, CCR, Expt Transplantat & Immunol Branch, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 MA 365 BP S61 EP S61 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353800362 ER PT J AU Patel, GK Lee, CL Montemarano, A Maggio, K Vogel, JC AF Patel, G. K. Lee, C. L. Montemarano, A. Maggio, K. Vogel, J. C. TI Development of human non-melanoma skin cancer stem cell assays SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Patel, G. K.; Lee, C. L.; Vogel, J. C.] NCI, Dermatol Branch, Bethesda, MD 20892 USA. [Montemarano, A.] Rockledge Skin Canc Ctr, Bethesda, MD USA. [Maggio, K.] Walter Reed Army Med Ctr, Dermatol Serv, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 BP S33 EP S33 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353800198 ER PT J AU Rouhani, P Fletcher, CD Devesi, S Toro, JR AF Rouhani, P. Fletcher, C. D. Devesi, S. Toro, J. R. TI Cutaneous soft tissue sarcoma incidence patterns in the surveillance, epidemiology, and end results program, 1978-2004: An analysis of 12,114 cases SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Rouhani, P.; Devesi, S.; Toro, J. R.] NCI, Div Canc Epidemiol & Genet, Rockville, MD USA. [Fletcher, C. D.] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 2 U2 3 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 BP S87 EP S87 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353800518 ER PT J AU Shukla, A Ho, Y Friesen, T Malik, M Suh, KS Yuspa, SH AF Shukla, A. Ho, Y. Friesen, T. Malik, M. Suh, K. S. Yuspa, S. H. TI CLIC4, in association with Schnurri-2 regulates TGF-beta signaling in skin keratinocytes SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Shukla, A.; Ho, Y.; Friesen, T.; Malik, M.; Suh, K. S.; Yuspa, S. H.] NIH, Lab Canc Biol & Genet, Bethesda, MD 20892 USA. RI Shukla, Anjali/G-4046-2014 NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 MA 786 BP S131 EP S131 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353800782 ER PT J AU Stewart, L Glenn, GM Stratton, P Goldstein, A Merino, MJ Tucker, MA Linehan, W Toro, JR AF Stewart, L. Glenn, G. M. Stratton, P. Goldstein, A. Merino, M. J. Tucker, M. A. Linehan, W. Toro, J. R. TI Germline mutations in the fumarate hydratase gene confer a predisposition to uterine fibroids in women with hereditary leiomyomatosis and renal cell cancer SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Stewart, L.; Glenn, G. M.; Goldstein, A.; Merino, M. J.; Tucker, M. A.; Linehan, W.; Toro, J. R.] NCI, Rockville, MD USA. [Stratton, P.] Natl Inst Child Hlth & Human Dev, Rockville, MD USA. RI Tucker, Margaret/B-4297-2015 NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 BP S87 EP S87 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353800515 ER PT J AU Strong, CD Sears, K Segre, JA AF Strong, C. de Guzman Sears, K. Segre, J. A. TI A genomics approach to identify cis-regulatory elements in the Epidermal Differentiation Complex (EDC) SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Strong, C. de Guzman; Segre, J. A.] NHGRI, Bethesda, MD 20892 USA. [Sears, K.] Univ Illinois, Urbana, IL 61801 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 MA 766 BP S128 EP S128 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353800763 ER PT J AU Therrien, JP Kim, S Terunuma, A Qin, Y Tock, CL Pfutzner, W Schernmann, J Vogel, JC AF Therrien, J. P. Kim, S. Terunuma, A. Qin, Y. Tock, C. L. Pfutzner, W. Schernmann, J. Vogel, J. C. TI Human skin gene therapy can be used to deliver anti-hypertensive atrial natriuretic peptide (ANP) in order to prevent blood pressure elevation in high-salt diet immunocompromised mice SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Therrien, J. P.; Terunuma, A.; Tock, C. L.; Vogel, J. C.] NCI, Bethesda, MD 20892 USA. [Kim, S.; Qin, Y.; Schernmann, J.] NIDDK, NIH, Bethesda, MD USA. [Pfutzner, W.] Univ Marburg, Marburg, Germany. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 MA 724 BP S121 EP S121 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353800721 ER PT J AU Toro, JR AF Toro, J. R. TI BHD mutations, clinical and genotype-phenotype investigations of 351 cases with Birt-Hogg-Dube syndrome SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Toro, J. R.] NCI, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 MA 773 BP S129 EP S129 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353800767 ER PT J AU Wright, LN Riss, J Ryscavage, A Yuspa, SH AF Wright, L. N. Riss, J. Ryscavage, A. Yuspa, S. H. TI Microarray analysis of ras-transformed keratinocytes genetically or pharmacologically ablated for the epidermal growth factor receptor (EGFR) reveals genetic signature and off-target drug effects. SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Wright, L. N.; Riss, J.; Ryscavage, A.; Yuspa, S. H.] NCI, NIH, LCBG, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 BP S33 EP S33 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353800193 ER PT J AU Rosenberg, HF AF Rosenberg, Helene F. TI The immunobiology of eosinophils - it's a whole new world out there: an interview with Dr. Peter F. Weller SO JOURNAL OF LEUKOCYTE BIOLOGY LA English DT Editorial Material C1 NIAID, Lab Allerg Dis, NIH, Bethesda, MD 20892 USA. RP Rosenberg, HF (reprint author), NIAID, Lab Allerg Dis, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. EM hrosenberg@niaid.nih.gov NR 2 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0741-5400 J9 J LEUKOCYTE BIOL JI J. Leukoc. Biol. PD APR 1 PY 2008 VL 83 IS 4 BP 822 EP 823 DI 10.1189/jlb.1307392 PG 2 WC Cell Biology; Hematology; Immunology SC Cell Biology; Hematology; Immunology GA 331NP UT WOS:000258019200004 ER PT J AU Watte, CM Nakamura, T Lau, CH Ortaldo, JR Stein-Streilein, J AF Watte, C. M. Nakamura, T. Lau, C. H. Ortaldo, J. R. Stein-Streilein, J. TI Ly49 C/I-dependent NKT cell-derived IL-10 is required for corneal graft survival and peripheral tolerance SO JOURNAL OF LEUKOCYTE BIOLOGY LA English DT Article DE NK inhibitory receptors; cytokines; immunosuppression ID T-REGULATORY CELLS; IMMUNE DEVIATION ACAID; ANTERIOR-CHAMBER; SYSTEMIC TOLERANCE; PRIVILEGED SITE; MARGINAL ZONE; B-CELLS; INDUCTION; ANTIGEN; RECEPTORS AB Similar to their activity on NK cells, Ly49 molecules play a pivotal role in influencing how NKT cells respond. It is known that Ly49 C/I is an inhibitory receptor capable of down-modulating proliferation, IFN-gamma response, and cytotoxic activity in cells that express it. In a model of peripheral tolerance induced via the eye, we observed that Ly49 C/I-positive, invariant NKT cells were required. To test if the NK inhibitory receptor functionally contributed to tolerance development, we used blocking antibody, in vivo and in vitro, to interfere with the development of antigen-specific suppression. A result of blocking ligation of Ly49 C/I inhibitory receptor prevented NKT cell production of IL-10 and the subsequent development of tolerance. Ly49 C/I-blocking antibodies also prevented corneal graft survival, a phenomenon dependent on eye-induced tolerance. Furthermore, in the presence of TCR stimulation, cross-linking of Ly49 C/I on CD4(+) NKT cells stimulated an increase in IL-10 mRNA and a decrease in IFN-gamma. The concept of Ly49 inhibitory receptors regulating immune reactivity to self by regulating immune activity of individual cells is thus expanded to include a role for the inhibitory receptors in the more global process of peripheral tolerance to foreign antigens. C1 [Watte, C. M.; Nakamura, T.; Lau, C. H.; Stein-Streilein, J.] Harvard Univ, Sch Med, Schepens Eye Res Inst, Dept Ophthalmol, Boston, MA 02114 USA. [Ortaldo, J. R.] NCI, Ctr Canc Res, Expt Immunol Lab, Frederick, MD USA. RP Stein-Streilein, J (reprint author), Harvard Univ, Sch Med, Schepens Eye Res Inst, Dept Ophthalmol, 20 Staniford St, Boston, MA 02114 USA. EM joan.stein@schepens.harvard.edu FU NEI NIH HHS [EY11983, EY016476] NR 39 TC 16 Z9 17 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0741-5400 J9 J LEUKOCYTE BIOL JI J. Leukoc. Biol. PD APR 1 PY 2008 VL 83 IS 4 BP 928 EP 935 DI 10.1189/jlb.0807579 PG 8 WC Cell Biology; Hematology; Immunology SC Cell Biology; Hematology; Immunology GA 331NP UT WOS:000258019200016 PM 18192489 ER PT J AU Wang, SB Zhang, JH Zhang, Y Kern, S Danner, RL AF Wang, Shuibang Zhang, Jianhua Zhang, Yi Kern, Steven Danner, Robert L. TI Nitric oxide-p38 MAPK signaling stabilizes mRNA through AU-rich element-dependent and -independent mechanisms SO JOURNAL OF LEUKOCYTE BIOLOGY LA English DT Article DE signal transduction; post-transcriptional gene regulation; HuR; hnRNP A0 ID ACTIVATED PROTEIN-KINASE; 3' UNTRANSLATED REGION; CYTOPLASMIC ACCUMULATION; RESPONSE ELEMENT; CELL-CYCLE; INHIBITION; HUR; EXPRESSION; ALPHA; DEGRADATION AB Regulation of mRNA stability by p38 MAPK has been linked to adenosine-uridine-rich elements (AURE) within the 3'-untranslated region (3'UTR) of mRNA. Using microarrays, we previously found that AURE-containing mRNA is over-represented among transcripts up-regulated by NO(center dot) ,an activator of p38 MAPK. Here, we investigated NO(center dot)-induced mRNA stabilization of specific AURE-containing genes to determine the sequence specificity and protein-binding interactions associated with this effect. IL-8, TNF-alpha, and p21/Waf1 3'UTRs were inserted into a luciferase (LUC) reporter gene system and found to decrease LUC activity and mRNA half-life in transfected THP-1 cells. The inhibitory effect of these 3'UTRs on LUC expression inversely correlated with the number of AUUUA motifs. Sequence truncation of the IL-8 3'UTR revealed that two segments, one with AURE sites and another without, contributed to mRNA destabilization. NO(center dot) activation of p38 MAPK increased LUC activity and mRNA half-life for reporter constructs that contained either of these IL-8 3'UTR segments. AURE-dependent and -independent NO(center dot) effects were blocked by p38 MAPK inhibition, and AURE-dependent effects were also blocked by site-directed mutagenesis of AUUUA sites. Two proteins, HuR and heterogeneous nuclear ribonucleoprotein A0, were identified, which bound to the AURE-containing region of exogenous and endogenous IL-8 mRNA in a NO(center dot)-p38 MAPK-dependent manner. These results demonstrate that NO(center dot)-p38 MAPK signaling can stabilize mRNA via AURE-dependent and -independent mechanisms. C1 [Wang, Shuibang; Zhang, Jianhua; Zhang, Yi; Kern, Steven; Danner, Robert L.] NIH, Dept Crit Care Med, Ctr Clin, Bethesda, MD 20892 USA. RP Danner, RL (reprint author), NIH, Dept Crit Care Med, Ctr Clin, Bldg 10,Rm 2C145, Bethesda, MD 20892 USA. EM rdanner@cc.nih.gov NR 37 TC 21 Z9 21 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0741-5400 J9 J LEUKOCYTE BIOL JI J. Leukoc. Biol. PD APR 1 PY 2008 VL 83 IS 4 BP 982 EP 990 DI 10.1189/jlb.0907641 PG 9 WC Cell Biology; Hematology; Immunology SC Cell Biology; Hematology; Immunology GA 331NP UT WOS:000258019200022 PM 18218858 ER PT J AU Biragyn, A Coscia, M Nagashima, K Sanford, M Young, HA Olkhanud, P AF Biragyn, Arya Coscia, Marta Nagashima, Kunio Sanford, Michael Young, Howard A. Olkhanud, Purevdorj TI Murine beta-defensin 2 promotes TLR-4/MyD88-mediated and NF-kappa B-dependent atypical death of APCs via activation of TNFR2 SO JOURNAL OF LEUKOCYTE BIOLOGY LA English DT Article DE antimicrobial peptide; DC maturation; immunomodulation ID TUMOR-NECROSIS-FACTOR; AIRWAY EPITHELIAL-CELLS; DENDRITIC CELLS; POLYMYXIN-B; MAST-CELLS; ANTIMICROBIAL ACTIVITY; ANTITUMOR IMMUNITY; INNATE IMMUNITY; LINKING INNATE; BETA-DEFENSINS AB Mammalian antimicrobial peptides, including beta-defensins, represent an ancient arm of innate immunity designed to directly neutralize invading microbes. Previously, we demonstrated that murine beta-defensin 2 (mDF2 beta) also acted as an endogenous ligand for TLR-4-activating maturation of dendritic cells (DCs). Herein, we report that this TLR-4-dependent activation leads to induction of an atypical cell death that is unexpectedly exaggerated by the inhibition of caspases. Experiments using APCs with nonfunctional TNF-alpha or its receptors suggest that this is a NF-kappa B- and TNF-alpha-dependent process that does not require TNFR1. We demonstrate that mDF2 beta triggers a TNFR2-mediated signaling cascade of "self-destruction" through up-regulation of membrane-bound TNF-alpha and TNFR2. This appears not to be an isolated phenomenon, as human synthetic beta-defenisn 3 was also able to activate and kill DCs. We propose that beta-defenins may play an important immunoregulatory role as controllers of the natural process of elimination of activated APCs. C1 [Biragyn, Arya; Olkhanud, Purevdorj] NIA, Immunol Lab, Gerontol Res Ctr, NIH, Baltimore, MD 21224 USA. [Nagashima, Kunio] Sci Applicat Int Corp Frederick Inc, Frederick, MD USA. [Sanford, Michael; Young, Howard A.] NCI, Expt Immunol Lab, Canc & Inflammat Program, Frederick, MD 21701 USA. [Coscia, Marta] Univ Turin, CeRMS, Azienda Osped San Giovanni Battista, Div Ematol,Lab Ematol Oncol, Turin, Italy. RP Biragyn, A (reprint author), NIA, Immunol Lab, Gerontol Res Ctr, NIH, 5600 Nathan Shock Dr,Box 21, Baltimore, MD 21224 USA. EM biragyna@mail.nih.gov RI coscia, marta/K-4832-2016 OI coscia, marta/0000-0003-2123-7675 FU Intramural NIH HHS [Z01 AG000770-04] NR 51 TC 38 Z9 40 U1 0 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0741-5400 J9 J LEUKOCYTE BIOL JI J. Leukoc. Biol. PD APR 1 PY 2008 VL 83 IS 4 BP 998 EP 1008 DI 10.1189/jlb.1007700 PG 11 WC Cell Biology; Hematology; Immunology SC Cell Biology; Hematology; Immunology GA 331NP UT WOS:000258019200024 PM 18192488 ER PT J AU Brock, JWC Jenkins, AJ Lyons, TJ Klein, RL Yim, E Lopes-Virella, M Carter, RE Thorpe, SR Baynes, JW AF Brock, Jonathan W. C. Jenkins, Alicia J. Lyons, Timothy J. Klein, Richard L. Yim, Eunsil Lopes-Virella, Maria Carter, Rickey E. Thorpe, Suzanne R. Baynes, John W. CA DCCT EDIC Res Grp TI Increased methionine sulfoxide content of apoA-I in type 1 diabetes SO JOURNAL OF LIPID RESEARCH LA English DT Article DE apolipoprotein A-I; high density lipoprotein; oxidation; oxidative stress ID HIGH-DENSITY-LIPOPROTEIN; APOLIPOPROTEIN-A-I; HUMAN BLOOD-PLASMA; OXIDATIVE STRESS; CHOLESTEROL EFFLUX; LIPID HYDROPEROXIDES; CELLULAR CHOLESTEROL; RECEPTOR BLOCKERS; SERUM PARAOXONASE; DCCT/EDIC COHORT AB Cardiovascular disease is a major cause of morbidity and premature mortality in diabetes. HDL plays an important role in limiting vascular damage by removing cholesterol and cholesteryl ester hydroperoxides from oxidized low density lipoprotein and foam cells. Methionine (Met) residues in apolipoprotein A-I (apoA-I), the major apolipoprotein of HDL, reduce peroxides in HDL lipids, forming methionine sulfoxide [Met(O)]. We examined the extent and sites of Met(O) formation in apoA-I of HDL isolated from plasma of healthy control and type I diabetic subjects to assess apoA-I exposure to lipid peroxides and the status of oxidative stress in the vascular compartment in diabetes. Three tryptic peptides of apoA-I contain Met residues: 84 M-86-K-88,W-108-M-112-R-116, and L-144-M-148-R-149. These peptides and their Met(O) analogs were identified and quantified by mass spectrometry. Relative to controls, Met(O) formation was significantly increased at all three locations (Met 86, Met(112), and Met(148)) in diabetic patients. The increase in Met(O) in the diabetic group did not correlate with other biomarkers of oxidative stress, such as N-is an element of-malondialdehyde-lysine or N-is an element of-(carboxymethyl)lysine, in plasma or lipoproteins. The higher Met(O) content in apoA-I from diabetic patients is consistent with increased levels of lipid peroxidation products in plasma in diabetes.W Using the methods developed here, future studies can address the relationship between Met(O) in apoA-I and the risk, development, or progression of the vascular complications of diabetes. C1 [Brock, Jonathan W. C.; Thorpe, Suzanne R.; Baynes, John W.] Univ S Carolina, Dept Chem & Biochem, Columbia, SC 29208 USA. [Jenkins, Alicia J.; Lyons, Timothy J.; Klein, Richard L.; Lopes-Virella, Maria] Med Univ S Carolina, Dept Endocrinol & Med Genet, Charleston, SC 29425 USA. [Yim, Eunsil; Carter, Rickey E.] Med Univ S Carolina, Dept Epidemiol & Biostat, Charleston, SC 29425 USA. [Jenkins, Alicia J.] Univ Melbourne, Dept Med, Melbourne, Vic, Australia. [DCCT EDIC Res Grp] NIH, Bethesda, MD 20892 USA. [Jenkins, Alicia J.; Lyons, Timothy J.] Univ Oklahoma, Hlth Sci Ctr, Oklahoma Diabet Ctr, Oklahoma City, OK USA. RP Baynes, JW (reprint author), Univ S Carolina, Dept Chem & Biochem, Columbia, SC 29208 USA. EM john.baynes@sc.edu RI Jenkins, Alicia/N-2482-2015 FU NIDDK NIH HHS [DK-19971] NR 59 TC 28 Z9 28 U1 0 U2 1 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0022-2275 EI 1539-7262 J9 J LIPID RES JI J. Lipid Res. PD APR PY 2008 VL 49 IS 4 BP 847 EP 855 DI 10.1194/jlr.M800015-JLR200 PG 9 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 280IV UT WOS:000254420800015 PM 18202432 ER PT J AU Camp, EA Coker, AL Troisi, R Robboy, SJ Noller, KL Goodman, KJ Titus-Ernstoff, LT Hatch, EE Herbst, AL Kaufman, RH Adam, E AF Camp, Elizabeth A. Coker, Ann L. Troisi, Rebecca Robboy, Stanley J. Noller, Kenneth L. Goodman, Karen J. Titus-Ernstoff, Linda T. Hatch, Elizabeth E. Herbst, Arthur L. Kaufman, Raymond H. Adam, Ervin TI Cervical Screening and General Physical Examination Behaviors of Women Exposed In Utero to Diethylstilbestrol SO JOURNAL OF LOWER GENITAL TRACT DISEASE LA English DT Article DE diethylstilbestrol; physical examination; vaginal smears ID YOUNG-WOMEN; CANCER; VAGINA AB Objective. To estimate whether women exposed in utero to diethylstilbestrol (DES) report receiving more cervical and general physical examinations compared to unexposed women. Materials and Methods. 1994 Diethylstilbestrol Adenosis cohort data are used to assess the degree of recommended compliance of cervical screenings found in 3,140 DESexposed and 826 unexposed women. Participants were enrolled at 4 sites: Houston, Boston, Rochester, and Los Angeles. Logistic regression modeling was used to analyze mailed questionnaire data, which included reported frequency over the preceding 5 years (1990-1994) of Papanicolaou smears and general physical examinations. Results. Diethylstilbestrol-exposed women exceeded the recommended frequency of Papanicolaou smear screenings [adjusted odds ratio (aOR) = 2.15, 95% Cl (confidence interval) = 1.60-2.88] compared to the unexposed. This association held among those without a history of cervical intraepithelial neoplasia (aOR = 1.88, 95% Cl = 1.35-2.62). Diethylstilbestrol-exposed women exceeded annual recommendations for physical examinations (aOR = 2.27, 95% Cl = 1.16-4.43) among women without a history of chronic disease when compared to unexposed women. Conclusions. Most DES-exposed women are receiving cervical cancer screening at least at recommended intervals, but one third of the women are not receiving annual Papanicolaou smear examinations. C1 [Camp, Elizabeth A.; Coker, Ann L.; Goodman, Karen J.] Univ Texas Hlth Sci Ctr, Sch Publ Hlth, Houston, TX USA. [Troisi, Rebecca] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. [Robboy, Stanley J.] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA. [Robboy, Stanley J.] Duke Univ, Med Ctr, Dept Obstet & Gynecol, Durham, NC 27710 USA. [Noller, Kenneth L.] Univ Massachusetts, Med Ctr, Dept Obstet & Gynecol, Worcester, MA USA. [Titus-Ernstoff, Linda T.] Dartmouth Hitchcock Med Ctr, Norris Cotton Canc Ctr, Lebanon, NH 03766 USA. [Hatch, Elizabeth E.] Boston Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Boston, MA USA. [Herbst, Arthur L.] Univ Chicago, Dept Obstet & Gynecol, Chicago, IL 60637 USA. [Kaufman, Raymond H.; Adam, Ervin] Baylor Coll Med, Dept Obstet & Gynecol, Houston, TX 77030 USA. [Kaufman, Raymond H.] Methodist Hosp, Dept Obstet & Gynecol, Houston, TX 77030 USA. [Adam, Ervin] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA. RP Kaufman, RH (reprint author), 6550 Fannin,Suite 900, Houston, TX 77030 USA. EM rkaufman@tmh.tmc.edu RI Goodman, Karen/D-6823-2013 OI Goodman, Karen/0000-0002-3790-3217 FU National Cancer Institute [1-CP-21166] FX This study was supported by the National Cancer Institute under contract #1-CP-21166. NR 22 TC 3 Z9 3 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1089-2591 J9 J LOW GENIT TRACT DI JI J. Low. Genit. Tract. Dis. PD APR PY 2008 VL 12 IS 2 BP 111 EP 117 PG 7 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 382GJ UT WOS:000261593300007 PM 18369304 ER PT J AU Hsu, LY Kellman, P Arai, AE AF Hsu, Li-Yueh Kellman, Peter Arai, Andrew E. TI Nonlinear myocardial signal intensity correction improves quantification of contrast-enhanced first-pass MR perfusion in humans SO JOURNAL OF MAGNETIC RESONANCE IMAGING LA English DT Article DE myocardial perfusion; myocardial blood flow; myocardial perfusion reserve; contrast agent; gadolinium; dipyridamole ID CORONARY-ARTERY-DISEASE; CARDIOVASCULAR MAGNETIC-RESONANCE; POSITRON-EMISSION-TOMOGRAPHY; NONINVASIVE DETECTION; FLOW RESERVE; ANGIOGRAPHY; BOLUS; ATHEROSCLEROSIS; MULTISLICE; SEQUENCE AB Purpose: To study the nonlinearity of myocardial signal intensity and gadolinium contrast concentration during first-pass perfusion MRI, and to compare quantitative perfusion estimates using nonlinear myocardial signal intensity correction. Materials and Methods: The nonlinearity of signal intensity and contrast concentration was simulated by magnetization modeling and evaluated in phantom measurements. A total of 10 healthy volunteers underwent rest and stress dual-bolus perfusion studies using an echo-planar imaging sequence at both short and long saturation-recovery delay times (TD70 and TD150). Perfusion estimates were compared before and after the correction. Results: The phantom data showed a linear relationship (R-2 = 1.00 and 0.99) of corrected signal intensity vs. contrast concentrations. Peak myocardial contrast concentration averaged 0.64 +/- 0.10 mmol . L-1 at rest and 0.91 +/- 0.21 mmol . L-1 during stress for TD70 and were similar for TD150 (P = not significant [NS]). The corrections were larger for stress than rest perfusion and larger for TD150 than TD70 studies (both P < 0.01). Perfusion estimates of TD70 and TD150 stress studies were significantly different before the correction (P < 0.01) but equivalent after the correction (P = NS). Conclusion: The nonlinearity between signal intensity and myocardial contrast concentration in perfusion MRI can be corrected through magnetization modeling. A nonlinear correction of myocardial signal intensity is feasible and improves quantitative perfusion analysis. C1 [Hsu, Li-Yueh; Kellman, Peter; Arai, Andrew E.] NHLBI, Cardiac Energet Lab, Natl Inst Hlth, Bethesda, MD 20892 USA. RP Hsu, LY (reprint author), NHLBI, Cardiac Energet Lab, Natl Inst Hlth, 10 Ctr Dr,MSC 1061Bldg 10,Room B1D-416, Bethesda, MD 20892 USA. EM lyhsu@nhlbi.nih.gov NR 40 TC 31 Z9 31 U1 0 U2 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1053-1807 J9 J MAGN RESON IMAGING JI J. Magn. Reson. Imaging PD APR PY 2008 VL 27 IS 4 BP 793 EP 801 DI 10.1002/jmri.21286 PG 9 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 284MC UT WOS:000254709500015 PM 18302205 ER PT J AU Sampath, S Kim, JH Lederman, RJ McVeigh, ER AF Sampath, Smita Kim, June H. Lederman, Robert J. McVeigh, Elliot R. TI Simultaneous imaging of myocardial motion and chamber blood flow with SPAMM n' EGGS (Spatial Modulation of Magnetization with Encoded Gradients for Gauging Speed) SO JOURNAL OF MAGNETIC RESONANCE IMAGING LA English DT Article DE myocardial motion; blood flow; velocity; tagging; phase-contrast; SPAMM; MRI ID MITRAL REGURGITATION; HUMAN-HEART; TRACKING; VELOCITY; MRI; CONTRAST; QUANTIFICATION; CARDIOMYOPATHY; DYSSYNCHRONY; DENSE AB Purpose: To provide simultaneous measurements of one-dimensional (1-D) myocardial displacement and 1-D chamber blood flow in a single breath-held acquisition using an MR imaging technique, SPAMM n' EGGS (Spatial Modulation of Magnetization With Encoded Gradients for Gauging Speed). Materials and Methods: Velocity encoding bipolar gradients sensitive to chamber blood flow were played out before the readout gradient in a 1 - 1 SPAMM-tagged MR imaging pulse sequence. For any given motion-flow encoded direction, the acquired image sequence was later postprocessed to separate the tag motion and blood flow terms. Experiments were performed on seven normal volunteers, and two pigs with moderate ischemic mitral regurgitation. Left-ventricular motion and trans-valvular flow obtained using the SPAMM n' EGGS pulse sequence was compared against measurements obtained using standard tagging and phase-contrast pulse sequences, respectively. Results: Results in normal volunteers and diseased pigs demonstrate multiphase correlated measurements of myocardial motion and chamber blood flow using SPAMM n' EGGS. A close correspondence in these measurements to conventional tagging and phase-contrast sequences is confirmed. Conclusion: We have demonstrated that simultaneous acquisition of myocardial motion and chamber blood flow is possible within a single breath-hold. The data obtained using the SPAMM n' EGGS pulse sequence may be useful in the planning and evaluation of mitral-valve repair procedures. C1 [Sampath, Smita; Lederman, Robert J.; McVeigh, Elliot R.] NHLBI, Natl Inst Hlth, Cardiac Energet Lab, DHHS, Bethesda, MD 20892 USA. [Kim, June H.] NHLBI, Cardiovasc Branch, Div Intramural Res, Natl Inst Hlth,DHHS, Bethesda, MD 20892 USA. RP McVeigh, ER (reprint author), NHLBI, Natl Inst Hlth, Cardiac Energet Lab, DHHS, Bldg 10,Room B1D-416 MSC 1061, Bethesda, MD 20892 USA. EM sampaths@mail.nih.gov OI lederman, robert/0000-0003-1202-6673 FU Intramural NIH HHS [NIH0012028025, Z01 HL005062-05] NR 25 TC 7 Z9 7 U1 0 U2 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1053-1807 J9 J MAGN RESON IMAGING JI J. Magn. Reson. Imaging PD APR PY 2008 VL 27 IS 4 BP 809 EP 817 DI 10.1002/jmri.21295 PG 9 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 284MC UT WOS:000254709500017 PM 18383258 ER PT J AU Bingjun, T Yoshida, H Yan, W Lin, L Tsuji, T Shimizu, H Miyamura, T AF Bingjun, Tian Yoshida, Hirornu Yan, Wu Lin, Lu Tsuji, Takao Shimizu, Hiroyuki Miyamura, Tatsuo TI Molecular typing and epidemiology of non-polio enteroviruses isolated from Yunnan Province, the People's Republic of China SO JOURNAL OF MEDICAL VIROLOGY LA English DT Article DE enterovirus; molecular typing; epidemiology ID ACUTE FLACCID PARALYSIS; UNTYPABLE ENTEROVIRUSES; SPECIES-C; SURVEILLANCE; IDENTIFICATION; SEQUENCE; VP1; SUBSTITUTIONS; ENCEPHALITIS; INFECTION AB This report presents an overview of human enteroviruses in Yunnan Province, the People's Republic of China. A total of 210 non-polioviruses isolated under acute flaccid paralysis (AFP) surveillance during a total study period of 5 years-1997 to 2000 and 2004-were examined. Of the 210 non-poliovirus isolates, 12 adenoviruses were serologically identified, and the remaining 198 isolates were used for molecular typing. The viral genomes of 195 non-polio enteroviruses (NPEVs) on VP1 partial region of virus capsid were translated to the corresponding amino acid sequences; these were compared with those of prototype strains. Based on molecular typing, 5 isolates were classified into 5 serotypes of the human enterovirus A species, 158 isolates, into 35 serotypes of the human enterovirus B species; and 32 isolates, into 6 serotypes of the human enterovirus C species. Viruses belonging to the human enterovirus D species were not isolated. Thus, under AFP surveillance, the human enterovirus B species accounted for 75.2% of the 210 isolates, and it was considered the predominant species. This was followed by human enterovirus C(12.2%), adenovirus (5.7%), and human enterovirus A (2.4%). Further, molecular analysis suggested that several serotypes of human enteroviruses B and C that exhibited genetic polymorphism were indigenous. Molecular typing methods may aid in understanding the epidemiology of NPEVs in Yunnan Province. C1 [Yoshida, Hirornu; Shimizu, Hiroyuki] NIAID, Dept Virol 2, Tokyo 2080011, Japan. [Bingjun, Tian; Yan, Wu; Lin, Lu] Yunnan Ctr Dis Control & Prevent, Polio Lab, Kunming, Yunnan Province, Peoples R China. [Tsuji, Takao] Fujita Hlth Univ, Sch Med, Dept Microbiol, Toyoake, Aichi 47011, Japan. RP Yoshida, H (reprint author), NIAID, Dept Virol 2, 4-7-1 Gakuen,Musashimurayama Shi, Tokyo 2080011, Japan. EM hyoshida@nih.go.jp NR 41 TC 45 Z9 55 U1 1 U2 2 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0146-6615 J9 J MED VIROL JI J. Med. Virol. PD APR PY 2008 VL 80 IS 4 BP 670 EP 679 DI 10.1002/jmv.21122 PG 10 WC Virology SC Virology GA 271LL UT WOS:000253789800016 PM 18297723 ER PT J AU Ma, YB Sun, CP Fields, M Li, Y Haake, DA Churchill, BM Ho, CM AF Ma, Yanbao Sun, Chien-Pin Fields, Michael Li, Yang Haake, David A. Churchill, Bernard M. Ho, Chih-Ming TI An unsteady microfluidic T-form mixer perturbed by hydrodynamic pressure SO JOURNAL OF MICROMECHANICS AND MICROENGINEERING LA English DT Article ID ELECTROOSMOTIC FLOW; CHAOTIC MIXER; MICROCHANNELS; MICROMIXERS; GEOMETRY; CHANNELS; DEVICES; DRIVEN; CHIP AB An unsteady microfluidic T-form mixer driven by pressure disturbances was designed and investigated. The performance of the mixer was examined both through numerical simulation and experimentation. Linear Stokes equations were used for these low Reynolds number flows. Unsteady mixing in a micro-channel of two aqueous solutions differing in concentrations of chemical species was described using a convection-dominated diffusion equation. The task was greatly simplified by employing linear superimposition of a velocity field for solving a scalar species concentration equation. Low-order-based numerical codes were found not to be suitable for simulation of a convection-dominated mixing process due to erroneous computational dissipation. The convection-dominated diffusion problem was addressed by designing a numerical algorithm with high numerical accuracy and computational-cost effectiveness. This numerical scheme was validated by examining a test case prior to being applied to the mixing simulation. Parametric analysis was performed using this newly developed numerical algorithm to determine the best mixing conditions. Numerical simulation identified the best mixing condition to have a Strouhal number (St) of 0.42. For a T-junction mixer (with channel width = 196 mu m), about 75% mixing can be finished within a mixing distance of less than 3 mm (i.e. 15 channel width) at St = 0.42 for flow with a Reynolds number less than 0.24. Numerical results were validated experimentally by mixing two aqueous solutions containing yellow and blue dyes. Visualization of the flow field under the microscope revealed a high level of agreement between numerical simulation and experimental results. C1 [Ma, Yanbao; Sun, Chien-Pin; Fields, Michael; Ho, Chih-Ming] Univ Calif Los Angeles, Dept Mech & Aerosp Engn, Los Angeles, CA 90095 USA. [Li, Yang; Haake, David A.; Churchill, Bernard M.] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA. [Haake, David A.] Vet Affairs Greater Los Angeles Healthcare Ctr, Los Angeles, CA 90073 USA. [Ho, Chih-Ming] NIH, Ctr Cell Control, Nanomed Dev Ctr, Bethesda, MD USA. RP Ma, YB (reprint author), Univ Calif Los Angeles, Dept Mech & Aerosp Engn, Los Angeles, CA 90095 USA. EM yanbao@seas.ucla.edu FU NIAID NIH HHS [U01 AI075565, U01 AI075565-01, U54 AI065359, U54 AI065359-030019]; NIBIB NIH HHS [R01 EB000127]; NIDDK NIH HHS [R33 DK070328, R33 DK070328-02] NR 43 TC 8 Z9 8 U1 1 U2 19 PU IOP PUBLISHING LTD PI BRISTOL PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND SN 0960-1317 J9 J MICROMECH MICROENG JI J. Micromech. Microeng. PD APR PY 2008 VL 18 IS 4 AR 045015 DI 10.1088/0960-1317/18/4/045015 PG 14 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Applied SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA 276OL UT WOS:000254151800015 PM 19177174 ER PT J AU Fisher, MJ Basu, S Dombi, E Yu, JQ Widemann, BC Pollock, AN Cnaan, A Zhuang, HM Phillips, PC Alavi, A AF Fisher, Michael J. Basu, Sandip Dombi, Eva Yu, Jian Q. Widemann, Brigitte C. Pollock, Avrum N. Cnaan, Avital Zhuang, Hongming Phillips, Peter C. Alavi, Abass TI The role of [18F]-fluorodeoxyglucose positron emission tomography in predicting plexiform neurofibroma progression SO JOURNAL OF NEURO-ONCOLOGY LA English DT Article DE FDG; fluorodeoxyglucose; MRI; neurofibroma; neurofibromatosis type 1; NF1; PET; plexiform; positron emission tomography ID NERVE SHEATH TUMORS; FDG-PET; SARCOMATOUS TRANSFORMATION; MUSCULOSKELETAL TUMORS; (18)FDG PET; TYPE-1; LESIONS; GENE; LYMPHOMA; THERAPY AB Background The role of FDG-PET for managing patients with plexiform neurofibromas (PN) is unclear. While many PN tumors exhibit periods of rapid growth, others grow slowly or unpredictably and may have periods of relative quiescence. The ability to predict which PN are likely to progress should facilitate a more timely initiation of medical treatments. Since conventional radiographic techniques have limited prognostic value, the use of a functional imaging modality to predict tumor progression is desirable. We hypothesized that PN tumors with high metabolic activity as demonstrated by FDG-PET are more likely to progress in the following year. Methods All patients were clinically stable, but were considered at high-risk for progression based on anatomical location of PN. FDG-PET scans were performed within two weeks of the baseline MRI study. Standardized uptake values (SUV) were calculated for all focally active index lesions and analyzed for correlation with changes in quantitative MRI over the ensuing year. Results Fifteen of the 18 enrolled patients showed various degrees of FDG uptake as focal abnormalities, and these abnormalities corresponded to those noted on the MRI scans. Thirteen patients and 19 lesions were evaluable for PN volume change. The SUVmax ranged from 0.9 to 4 (median 1.5). There was a significant difference in the percent increase in PN volume in the following year for lesions that had an SUV > 2 compared to those with lower values (P = 0.016). Conclusions These findings support the hypothesis that FDG-PET imaging predicts PN growth rate, and, therefore, may assist clinician decision making with regard to treatment of PN and enrollment in clinical trials. C1 [Fisher, Michael J.; Phillips, Peter C.] Childrens Hosp Philadelphia, Div Oncol, Philadelphia, PA 19104 USA. [Fisher, Michael J.; Pollock, Avrum N.; Cnaan, Avital; Zhuang, Hongming; Phillips, Peter C.; Alavi, Abass] Univ Penn, Sch Med, Philadelphia, PA 19104 USA. [Basu, Sandip; Yu, Jian Q.; Zhuang, Hongming; Alavi, Abass] Hosp Univ Penn, Div Nucl Med, Philadelphia, PA 19104 USA. [Dombi, Eva; Widemann, Brigitte C.] NCI, Pediat Oncol Branch, Bethesda, MD 20892 USA. [Pollock, Avrum N.] Childrens Hosp Philadelphia, Dept Radiol, Philadelphia, PA 19104 USA. [Cnaan, Avital] Childrens Hosp Philadelphia, Div Biostat & Epidemiol, Philadelphia, PA 19104 USA. RP Fisher, MJ (reprint author), Childrens Hosp Philadelphia, Div Oncol, 34th St & Civ Ctr Blvd, Philadelphia, PA 19104 USA. EM fisherm@email.chop.edu FU NCI NIH HHS [CA 15488] NR 32 TC 14 Z9 15 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-594X J9 J NEURO-ONCOL JI J. Neuro-Oncol. PD APR PY 2008 VL 87 IS 2 BP 165 EP 171 DI 10.1007/s11060-007-9501-5 PG 7 WC Oncology; Clinical Neurology SC Oncology; Neurosciences & Neurology GA 279NF UT WOS:000254361200005 PM 18071635 ER PT J AU Park, JK Ngo, T Peng, T AF Park, John K. Ngo, Teri Peng, Tien TI The role of stathmin in the chemosensitivity of malignant gliomas with 1p LOH SO JOURNAL OF NEURO-ONCOLOGY LA English DT Meeting Abstract C1 [Park, John K.] NINDS, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-594X J9 J NEURO-ONCOL JI J. Neuro-Oncol. PD APR PY 2008 VL 87 IS 2 BP 209 EP 209 PG 1 WC Oncology; Clinical Neurology SC Oncology; Neurosciences & Neurology GA 279NF UT WOS:000254361200042 ER PT J AU Calabrese, M De Stefano, N Atzori, M Bernardi, V Mattisi, I Barachino, L Rinaldi, L Morra, A McAuliffe, MMJ Perini, P Battistin, L Gallo, P AF Calabrese, Massimiliano De Stefano, Nicola Atzori, Matteo Bernardi, Valentina Mattisi, Irene Barachino, Luigi Rinaldi, Luciano Morra, Aldo McAuliffe, Matthew M. J. Perini, Paola Battistin, Leontino Gallo, Paolo TI Extensive cortical inflammation is associated with epilepsy in multiple sclerosis SO JOURNAL OF NEUROLOGY LA English DT Article DE cortical lesions; multiple sclerosis; epilepsy ID DIAGNOSTIC-CRITERIA; LESIONS; SEIZURES; BRAIN; PROGNOSIS; ATROPHY AB Introduction Epilepsy is three to six times more frequent in MS than in the general population. Previous studies based on conventional magnetic resonance (MR) imaging have suggested a possible correlation between cortical inflammatory pathology and epileptic seizures. However, pure intracortical lesions (ICLs) are unlikely to be demonstrated with conventional MR. We applied the double inversion recovery (DIR) sequence in relapsing remitting MS (RRMS) patients with or without epileptic seizures in order to clarify the relationship between ICLs and epilepsy in MS in vivo. Methods Twenty RRMS patients who had epileptic seizures (RRMS/E) during the course of the disease were studied for the presence of ICLs. A group of 80 RRMS patients with no history of seizures and matched for gender, age, disease duration, Expanded Disability Status Scale (EDSS) grading, and T2 lesion volume (T2-WMLV) was selected as reference population. ICLs were detected by applying the DIR sequence. Results ICLs were observed in 18/20 (90%) RRMS/E and in 39/80 (48%) RRMS (p = 0.001). RRMS/E showed five times more ICLs (7.2 +/- 8.4) than RRMS (1.5 +/- 2.4; p = 0.015). The total ICLs volume was 6 times larger in RRMS/E than in RRMS (1.2 +/- 1.7cm(3) versus 0.2 +/- 0.2cm(3), p = 0.016). No significant difference was observed between RRMS and RRMS/E with regard to the number and volume of juxtacortical lesions and T2-WMLV. Discussion Our findings indicate that RRMS/E have more extensive cortical inflammation than RRMS patients with no history of epilepsy. Inflammatory ICLs may be responsible for epilepsy in MS. C1 [Calabrese, Massimiliano; Atzori, Matteo; Bernardi, Valentina; Mattisi, Irene; Rinaldi, Luciano; Perini, Paola; Battistin, Leontino; Gallo, Paolo] Univ Hosp Padova, Dept Neurosci, Neurol Clin 1, Multiple Sclerosis Ctr Veneto Reg, I-35128 Padua, Italy. [De Stefano, Nicola; Battistin, Leontino] Univ Siena, Dept Neurol & Behav Sci, Quantitat Neuroimaging Lab, I-53100 Siena, Italy. [Barachino, Luigi; Morra, Aldo; Battistin, Leontino] Euganea Med, Neuroradiol Unit, Padua, Italy. [McAuliffe, Matthew M. J.; Battistin, Leontino] NIH, Biomed Imaging Res Serv Sect, Bethesda, MD 20892 USA. [Battistin, Leontino] IRCCS San Camillo, Lido Di Venezia, Italy. RP Calabrese, M (reprint author), Univ Hosp Padova, Dept Neurosci, Neurol Clin 1, Multiple Sclerosis Ctr Veneto Reg, Via Giustiniani 5, I-35128 Padua, Italy. EM calabresem@hotmail.it NR 27 TC 62 Z9 62 U1 0 U2 0 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0340-5354 J9 J NEUROL JI J. Neurol. PD APR PY 2008 VL 255 IS 4 BP 581 EP 586 DI 10.1007/s00415-008-0752-7 PG 6 WC Clinical Neurology SC Neurosciences & Neurology GA 292GU UT WOS:000255255300017 PM 18227989 ER PT J AU Schofield, GG Puhl, HL Ikeda, SR AF Schofield, Geoffrey G. Puhl, Henry L., III Ikeda, Stephen R. TI Properties of wild-type and fluorescent protein-tagged mouse tetrodotoxin-resistant sodium channel (Na(V)1.8) heterologously expressed in rat sympathetic neurons SO JOURNAL OF NEUROPHYSIOLOGY LA English DT Article ID PRIMARY SENSORY NEURONS; DORSAL-ROOT GANGLIA; ALPHA-SUBUNIT; FUNCTIONAL EXPRESSION; NA-CHANNEL; SNS; CURRENTS; CELLS; BRAIN; PAIN AB The tetrodotoxin (TTX)-resistant Na+ current arising from Na(V)1.8-containing channels participates in nociceptive pathways but is difficult to functionally express in traditional heterologous systems. Here, we show that injection of cDNA encoding mouse Na(V)1.8 into the nuclei of rat superior cervical ganglion (SCG) neurons results in TTX-resistant Na+ currents with amplitudes equal to or exceeding the currents arising from natively expressing channels of mouse dorsal root ganglion (DRG) neurons. The activation and inactivation properties of the heterologously expressed Na(V)1.8 Na+ channels were similar but not identical to native TTX-resistant channels. Most notably, the half-activation potential of the heterologously expressed Na(V)1.8 channels was shifted about 10 mV toward more depolarized potentials. Fusion of fluorescent proteins to the N- or C-termini of Na(V)1.8 did not substantially affect functional expression in SCG neurons. Unexpectedly, fluorescence was not concentrated at the plasma membrane but found throughout the interior of the neuron in a granular pattern. A similar expression pattern was observed in nodose ganglion neurons expressing the tagged channels. In contrast, expression of tagged Na(V)1.8 in HeLa cells revealed a fluorescence pattern consistent with sequestration in the endoplasmic reticulum, thus providing a basis for poor functional expression in clonal cell lines. Our results establish SCG neurons as a favorable surrogate for the expression and study of molecularly defined Na(V)1.8-containing channels. The data also indicate that unidentified factors may be required for the efficient functional expression of Na(V)1.8 with a biophysical phenotype identical to that found in sensory neurons. C1 [Puhl, Henry L., III; Ikeda, Stephen R.] NIAAA, Sect Transmitter Signaling, Lab Mol Physiol, NIH, Bethesda, MD 20892 USA. [Schofield, Geoffrey G.] Tulane Univ, Hlth Sci Ctr, Dept Physiol, New Orleans, LA 70118 USA. RP Ikeda, SR (reprint author), NIAAA, Sect Transmitter Signaling, Lab Mol Physiol, NIH, 5625 Fishes Lane,MSC 9411, Bethesda, MD 20892 USA. EM sikeda@mail.nih.gov OI Ikeda, Stephen/0000-0002-4088-9508; Puhl, Henry/0000-0003-3095-7201 FU Intramural NIH HHS NR 49 TC 4 Z9 5 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-3077 J9 J NEUROPHYSIOL JI J. Neurophysiol. PD APR PY 2008 VL 99 IS 4 BP 1917 EP 1927 DI 10.1152/jn.01170.2007 PG 11 WC Neurosciences; Physiology SC Neurosciences & Neurology; Physiology GA 286EX UT WOS:000254829800030 PM 18272876 ER PT J AU Lonser, RR Baggenstos, M Kim, HJ Butman, JA Vortmeyer, AO AF Lonser, Russell R. Baggenstos, Martin Kim, H. Jeffrey Butman, John A. Vortmeyer, Alexander O. TI The vestibular aqueduct: site of origin of endolymphatic sac tumors SO JOURNAL OF NEUROSURGERY LA English DT Article DE anatomy; endolymphatic sac tumor; origin; pathology; vestibular aqueduct ID HIPPEL-LINDAU-DISEASE AB Object. Although endolymphatic sac tumors (ELSTs) frequently destroy the posterior petrous bone and cause hearing loss, the anatomical origin of these neoplasms is unknown. To determine the precise topographic origin of ELSTs, the authors analyzed the imaging, operative, and pathological findings in patients with von Hippel-Lindau disease (VHL) and ELSTs. Methods. Consecutive VHL patients with small (<= 1.5 cm) ELSTs who underwent resection at the National Institutes of Health were included. Clinical, imaging, operative, and pathological findings were analyzed. Results. Ten consecutive VHL patients (6 male and 4 female) with 10 small ELSTs (<= 1.5 cm; 9 left, 1 right) were included. Serial imaging captured the development of 6 ELSTs and revealed that they originated within the intraosseous (vestibular aqueduct) portion of the endolymphatic duct/sac system. Imaging just before surgery demonstrated that the epicenters of 9 ELSTs (1 ELST was not visible on preoperative imaging) were in the vestibular aqueduct. Inspection during surgery established that all 10 ELSTs were limited to the intraosseous endolymphatic duct/sac and the immediately surrounding region. Histological analysis confirmed tumor within the intraosseous portion (vestibular aqueduct) of the endolymphatic duct/sac in all 10 patients. Conclusions. ELSTs originate from endolymphatic epithelium within the vestibular aqueduct. High-resolution imaging through the region of the vestibular aqueduct is essential for diagnosis. Surgical exploration of the endolymphatic duct and sac is required for complete resection. C1 [Lonser, Russell R.; Baggenstos, Martin; Vortmeyer, Alexander O.] Natl Inst Disorders & Stroke, NIH, Surg Neurol Branch, Bethesda, MD 20892 USA. [Kim, H. Jeffrey] Natl Inst Deafness & Other Commun Disorders, NIH, Dept Otolaryngol, Bethesda, MD USA. [Butman, John A.] NIH, Ctr Clin, Dept Diagnost Radiol, Bethesda, MD 20892 USA. [Kim, H. Jeffrey] Georgetown Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, Washington, DC 20007 USA. RP Lonser, RR (reprint author), Natl Inst Disorders & Stroke, NIH, Surg Neurol Branch, Bldg 10,Room 5D37, Bethesda, MD 20892 USA. EM lonseff@ninds.nih.gov RI Butman, John/A-2694-2008; OI Butman, John/0000-0002-1547-9195 FU Intramural NIH HHS [Z01 NS003053-01] NR 10 TC 20 Z9 23 U1 0 U2 1 PU AMER ASSOC NEUROLOGICAL SURGEONS PI ROLLING MEADOWS PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA SN 0022-3085 J9 J NEUROSURG JI J. Neurosurg. PD APR PY 2008 VL 108 IS 4 BP 751 EP 756 DI 10.3171/JNS/2008/108/4/0751 PG 6 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 279AA UT WOS:000254326200019 PM 18377255 ER PT J AU Zoghbi, SS Liow, JS Yasuno, F Hong, J Tuan, E Lazarova, N Gladding, RL Pike, VW Innis, RB AF Zoghbi, Sami S. Liow, Jeih-San Yasuno, Furnihiko Hong, Jinsoo Tuan, Edward Lazarova, Neva Gladding, Robert L. Pike, Victor W. Innis, Robert B. TI C-11-loperamide and its N-desmethyl radiometabolite are avid substrates for brain permeability-glycoprotein efflux SO JOURNAL OF NUCLEAR MEDICINE LA English DT Article DE C-11-loperamide; P-gp; brain efflux pump; PET; blood-brain barrier ID P-GLYCOPROTEIN; MULTIDRUG-RESISTANCE; NONHUMAN-PRIMATES; BLOOD; PET; TRANSPORTER; REVERSAL; BARRIER; RADIOLIGAND; SENSITIVITY AB Loperamide, an opiate receptor agonist, does not cross the blood-brain barrier because it is a substrate for the permeability-glycoprotein (P-gp) efflux pump. We evaluated C-11-loperamide as a PET radiotracer to measure P-gp function in vivo. Methods: Monkeys were injected with C-11-loperamide, and PET brain images were acquired for 120 min. The baseline scans were followed by scans acquired after administration of either of 2 P-gp inhibitors, (2R)-anti-5-{3-[4-(10,11-dichloromethanodibenzo-suber-5-yl)piperazin-1-yl]-2-hydroxypropoxy} quinoline trihydrochloride (DCPQ) or tariquidar. Both the PET scans and ex vivo measurements were obtained in P-gp knockout and wildtype mice. Results: Pharmacologic inhibition of P-gp in monkeys dose-dependently increased brain activity, with a 3.7-fold effect at the highest DCPQ dose (8 mg/kg intravenously). This increase of brain activity was not caused peripherally, because DCPQ insignificantly changed the plasma concentration and plasma protein binding of radiotracer. Furthermore, the structurally dissimilar inhibitor, tariquidar, also increased brain uptake with potency equal to that of DCPQ. P-gp knockout mice had 3-fold higher brain activity on PET than did wild-type animals. Four radiometabolites were detected in the plasma and brains of ex vivo mice. The most lipophilic radiometabolite was found to be comobile with reference dLop on high-performance liquid chromatography. The brain concentrations of 11 C-loperamide and the putative C-11-dLop were about 16-fold greater in P-gp knockout mice than in wild-type mice. Conclusion: Both C-11-loperamide and its putative radiometabolite C-11-dLop are avid P-gp substrates. C-11-dLop may be superior to C-11-loperamide in measuring P-gp function at the blood-brain barrier, because further demethylation of C-11-dLop will generate radiometabolites that have little entry into the brain. C1 [Zoghbi, Sami S.; Liow, Jeih-San; Yasuno, Furnihiko; Hong, Jinsoo; Tuan, Edward; Lazarova, Neva; Gladding, Robert L.; Pike, Victor W.; Innis, Robert B.] NIMH, NIH, Mol Imaging Branch, Bethesda, MD 20892 USA. RP Zoghbi, SS (reprint author), NIMH, NIH, Mol Imaging Branch, 31 Ctr Dr,Room B2-B37,MSC 2035, Bethesda, MD 20892 USA. EM sami.zoghbi@nih.gov FU Intramural NIH HHS NR 29 TC 64 Z9 64 U1 0 U2 3 PU SOC NUCLEAR MEDICINE INC PI RESTON PA 1850 SAMUEL MORSE DR, RESTON, VA 20190-5316 USA SN 0161-5505 J9 J NUCL MED JI J. Nucl. Med. PD APR PY 2008 VL 49 IS 4 BP 649 EP 656 DI 10.2967/jnumed.107.047308 PG 8 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 285ZB UT WOS:000254813600026 PM 18344435 ER PT J AU Sano, A Le, DSNT Tran, MHT Pham, HTN Kaneda, M Murai, E Kamiyama, H Oota, Y Yamamoto, S AF Sano, Ayami Le, Duc-Son Nguyen Trung Tran, Minh-Hanh Thi Pham, Ha Thi Ngan Kaneda, Masayo Murai, Eiko Kamiyama, Hisao Oota, Yumiko Yamamoto, Shigeru TI Study on factors of body image in Japanese and Vietnamese adolescents SO JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY LA English DT Article DE body image; thinness; adolescents; Japan; Vietnam AB Over-concern about thinness, especially among young girls including adolescents, is common in Japan. Behind the problem, there is a complicated social phenomenon and an effective strategy is not known yet. In this study, we tried to rind a clue by comparing body image between two countries which have different social backgrounds. Subjects were Japanese and Vietnamese junior high school students from 12 to 15 y old. Three schools each and 1-2 classes from each grade were randomly selected to involve 374 (boys 1.96, girls 178) and 71.4 (boys 352, girls 362), respectively, in Japan and Vietnam. Height and weight of subjects were measured and their satisfaction about their body shape and experience with dieting were asked by a questionnaire. Questions about their body image concerning their desire, liking of the opposite sex, own liking and health were answered by marking silhouettes. About 60%, of Japanese thought that obese (silhouette 9) is unhealthy, while about 85% of Vietnamese thought that thinness (silhouette 1) is unhealthy. Most of the Japanese girls overestimated their body weight and were dissatisfied with their body shape and 78.3% wanted to lose weight. About 30% of them experienced weight loss including 2.8%, of the low BMI students. Vietnamese girls also had similar tendencies in their desire about their body image as the Japanese but they were less serious. The girls in both countries preferred the thinner body image to the healthy body image and thought that boys liked the thinner body image. Japanese boys were mostly satisfied with their body shape; however. about half (46'%) of the Vietnamese boys wanted a bigger and more muscular body image. In conclusion, the biggest problem with body image was the over-concern about thinness of the Japanese girls. which was based on their own misconception. Therefore, as the strategy to correct their body image, education about good health and also information about the boys' favorite body image are recommended. C1 [Sano, Ayami; Yamamoto, Shigeru] Univ Tokushima, Grad Sch, Dept Int Publ Hlth Nutr, Tokushima 7708503, Japan. [Sano, Ayami] Univ Shizuoka, Sch Food & Nutr Sci, Dept Food Management, Shizuoka 4228526, Japan. [Le, Duc-Son Nguyen Trung] NIDDKD, NIH, Phoenix, AZ 85016 USA. [Le, Duc-Son Nguyen Trung; Tran, Minh-Hanh Thi; Pham, Ha Thi Ngan] Nutr Ctr Ho Chi Minh City, Ho Chi Minh City, Vietnam. [Kaneda, Masayo] Kagawa Nutr Univ, Jr Coll, Tokyo 1708481, Japan. [Murai, Eiko] Kokubunji Nanbu Elementary Sch, Kagawa 7690103, Japan. [Kamiyama, Hisao] Educ Board Tochigi Prefecture, Tochigi 3208501, Japan. [Oota, Yumiko] Educ Board Toyama Prefecture, Toyama 9308501, Japan. [Yamamoto, Shigeru] Ochanomizu Univ, Grad Sch Humanities & Sci, Bunkyo Ku, Tokyo 1128610, Japan. RP Yamamoto, S (reprint author), Univ Tokushima, Grad Sch, Dept Int Publ Hlth Nutr, Tokushima 7708503, Japan. EM yamamoto.shigeru@ocha.ac.jp NR 12 TC 11 Z9 11 U1 0 U2 3 PU CENTER ACADEMIC PUBL JAPAN PI TOKYO PA 2-4-16 YAYOI, BUNKYO-KU, TOKYO, 113-0032, JAPAN SN 0301-4800 EI 1881-7742 J9 J NUTR SCI VITAMINOL JI J. Nutr. Sci. Vitaminol. PD APR PY 2008 VL 54 IS 2 BP 169 EP 175 DI 10.3177/jnsv.54.169 PG 7 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 296PO UT WOS:000255558500009 PM 18490848 ER PT J AU Fukuda, MN Sugihara, K AF Fukuda, Michiko N. Sugihara, Kazuhiro TI An integrated view of L-selectin and trophinin function in human embryo implantation SO JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH LA English DT Article ID SCANNING ELECTRON-MICROSCOPY; ENDOMETRIAL EPITHELIAL-CELLS; HUMAN CHORIONIC-GONADOTROPIN; HUMAN TERATOCARCINOMA CELLS; HIGH ENDOTHELIAL VENULES; EPIDERMAL-GROWTH-FACTOR; SIALYL-LEWIS-X; MOUSE BLASTOCYSTS; LIGAND BIOSYNTHESIS; SIGNAL-TRANSDUCTION AB Determining molecular mechanisms of human embryo implantation is an extremely challenging task due to the limitation of materials and significant differences underlying this process among mammalian species. Recently, L-selectin and its ligand carbohydrate have been proposed as a system that mediates initial adhesion of human blastocysts to the uterine epithelia. We have also identified trophinin as a unique apical cell adhesion molecule potentially involved in the initial adhesion of trophectoderm of the human blastocyst to endometrial surface epithelia. In the mouse, the binding between ErbB4 on the blastocyst and heparin-binding epidermal growth factor-like growth factor on the endometrial surface enables the initial step of the blastocyst implantation. The evidence suggests that L-selectin and trophinin are included in human embryo implantation. This review summarizes findings relevant to the functions of L-selectin and trophinin in human embryo implantation, and proposes a model that reconciles these cell adhesion mechanisms. C1 [Fukuda, Michiko N.] Burnham Inst Med Res, NCI, Ctr Canc, Tumor Microenvironm Program,Glycobiol Unit, La Jolla, CA 92037 USA. [Sugihara, Kazuhiro] Hamamatsu Univ Sch Med, Dept Obstet & Gynecol, Hamamatsu, Shizuoka, Japan. RP Fukuda, MN (reprint author), Burnham Inst Med Res, NCI, Ctr Canc, Tumor Microenvironm Program,Glycobiol Unit, 10901 N Torrey Pines Rd, La Jolla, CA 92037 USA. EM michiko@burnham.org FU NCI NIH HHS [P01 CA071932, P01 CA071932-11A2] NR 84 TC 24 Z9 27 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1341-8076 EI 1447-0756 J9 J OBSTET GYNAECOL RE JI J. Obstet. Gynaecol. Res. PD APR PY 2008 VL 34 IS 2 BP 129 EP 136 DI 10.1111/j.1447-0756.2008.00776.x PG 8 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 288MQ UT WOS:000254990900001 PM 18412772 ER PT J AU Kessler, RC Merikangas, KR Wang, PS AF Kessler, Ronald C. Merikangas, Kathleen R. Wang, Philip S. TI The prevalence and correlates of workplace depression in the National Comorbidity Survey Replication SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Review ID WORLD-HEALTH-ORGANIZATION; PERFORMANCE QUESTIONNAIRE HPQ; DIAGNOSTIC INTERVIEW CIDI; COMMON MENTAL-DISORDERS; BIPOLAR-II-DISORDER; DSM-IV DISORDERS; UNITED-STATES; EPIDEMIOLOGIC SURVEY; ANXIETY DISORDERS; MAJOR DEPRESSION AB Objective: To review evidence on the workplace prevalence and correlates of major depressive episodes, with a particular focus on the National Comorbidity Survey Replication, the most recent national survey to focus on these issues. Method: Nationally representative survey of Diagnostic and Statistical Manual, 4th Revision Mental Disorders. Results: A total of 6.4% of employed National Comorbidity Survey Replication respondents had 12-month major depressive disorder. An additional 1.1% had major depressive episodes due to bipolar disorder or mania-hypomania. Only about half of depressed workers received treatment. Fewer than half of treated workers received care consistent with published treatment guidelines. Conclusions: Depression disease management programs can have a positive return-on-investment from the employer perspective, but only when they are based on best practices. Given the generally low depression treatment quality documented here, treatment quality guarantees are needed before expanding workplace depression screening, outreach, and treatment programs. C1 [Kessler, Ronald C.; Wang, Philip S.] Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA. [Merikangas, Kathleen R.] NIMH, Intramural Res Program, Sect Dev Genet Epidemiol, Bethesda, MD 20892 USA. [Wang, Philip S.] NIMH, Div Serv & Intervent Res, Bethesda, MD 20892 USA. [Wang, Philip S.] Brigham & Womens Hosp, Div Pharmacoepidemiol & Pharmacoecon, Boston, MA 02115 USA. RP Kessler, RC (reprint author), Harvard Univ, Sch Med, Dept Hlth Care Policy, 180 Longwood Ave, Boston, MA 02115 USA. EM Kesller@hcp.med.harvard.edu FU Intramural NIH HHS [Z01 MH002806-05]; NIDA NIH HHS [R01DA016558, R01 DA016558]; NIMH NIH HHS [R01 MH061941-04, R01-MH061941, R01-MH069864, U01 MH060220, R01 MH069864, R13 MH066849, U01-MH60220, 1R13MH066849, R01 MH061941, U01 MH060220-01] NR 103 TC 38 Z9 39 U1 3 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD APR PY 2008 VL 50 IS 4 BP 381 EP 390 DI 10.1097/JOM.0b013e31816ba9b8 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 290FG UT WOS:000255108100002 PM 18404010 ER PT J AU Wang, PS Simon, GE Kessler, RC AF Wang, Philip S. Simon, Gregory E. Kessler, Ronald C. TI Making the business case for enhanced depression care: The National Institute of Mental Health-Harvard Work Outcomes Research and Cost-Effectiveness Study SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; COMORBIDITY SURVEY REPLICATION; PERFORMANCE QUESTIONNAIRE HPQ; UNITED-STATES; COLLABORATIVE CARE; ECONOMIC BURDEN; PSYCHIATRIC-DISORDERS; TELEPHONE PSYCHOTHERAPY; ORGANIZATION HEALTH; SYMPTOMATOLOGY IDS AB Objective: Explore the business case for enhanced depression care and establish a return on investment rationale for increased organizational involvement by employer-purchasers. Method. Literature review, focused on the National Institute of Mental Health-sponsored Work Outcomes Research and Cost-effectiveness Study. Results: This randomized controlled trial compared telephone outreach, care management, and optional psychotherapy to usual care among depressed workers in large national corporations. By 12 months, the intervention significantly improved depression outcomes, work retention, and hours worked among the employed Conclusion: Results of the Work Outcomes Research and Cost-effectiveness Study trial and other studies suggest that enhanced depression care programs represent a human capital investment opportunity for employers. C1 [Wang, Philip S.] NIMH, Div Serv & Intervent Res, Rockville, MD 20857 USA. [Wang, Philip S.] Brigham & Womens Hosp, Div Pharmacoepidemiol & Pharmacoecon, Boston, MA 02115 USA. [Wang, Philip S.; Kessler, Ronald C.] Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA. [Simon, Gregory E.] Grp Hlth Cooperat Puget Sound, Ctr Hlth Studies, Seattle, WA 98101 USA. RP Wang, PS (reprint author), NIMH, Div Serv & Intervent Res, 6001 Execut Blvd,Rm 7141,MSC 9629, Bethesda, MD 20892 USA. EM wangphi@mail.nih.gov FU NIMH NIH HHS [R01 MH61941] NR 92 TC 27 Z9 27 U1 6 U2 20 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD APR PY 2008 VL 50 IS 4 BP 468 EP 475 DI 10.1097/JOM.0b013e31816a8931 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 290FG UT WOS:000255108100012 PM 18404020 ER PT J AU Meert, KL Eggly, S Dean, JM Pollack, M Zimmerman, J Anand, KJS Newth, CJL Willson, DF Nicholson, C AF Meert, Kathleen Lynn Eggly, Susan Dean, J. Michael Pollack, Murray Zimmerman, Jerry Anand, K. J. S. Newth, Christopher J. L. Willson, Douglas F. Nicholson, Carol TI Ethical and logistical considerations of multicenter parental bereavement research SO JOURNAL OF PALLIATIVE MEDICINE LA English DT Article ID CONGENITAL HEART-SURGERY; PALLIATIVE CARE; INTENSIVE-CARE; ILL PATIENTS; DEATH; CAREGIVERS; MORTALITY; SUPPORT; ISSUES; BOARDS AB Background: Multicenter research has the potential to recruit participants with diverse racial, ethnic, and geographic backgrounds and is essential for understanding heterogeneity in bereavement. The National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN) is a multicenter network charged with conducting research on the pathophysiology and management of critical illness in childhood. Among its research activities, the CPCCRN has undertaken research in parental bereavement because most childhood deaths in the United States occur in hospitals, primarily in critical care units. Objective: The purpose of this paper is to discuss ethical and logistical issues found by the CPCCRN to be problematic to multicenter research with bereaved parents and to explore research strategies that may be practicably implemented. Results: Ethical and logistical challenges encountered by the CPCCRN included issues of privacy; confidentiality; voluntariness; minimizing risks; working with multiple institutional review boards; researcher qualifications, training and support; and methods of data collection. Strategies to address these challenges included local recruitment of participants; flexibility in consent methods across sites; participant options for methods of data collection; involvement of local bereavement support services; central training of researchers with systematic monitoring and opportunitieas for support; and use of a secure Web-based collaborative workspace. Conclusions: Multicenter parental bereavement research has distinct ethical issues that must be addressed by the logistics of the research plan. Greater attention to the issues identified may facilitate research to reduce adverse mental and physical health outcomes in a diverse population of bereaved individuals. C1 [Meert, Kathleen Lynn] Wayne State Univ, Dept Pediat, Childrens Hosp Michigan, Detroit, MI 48201 USA. [Eggly, Susan] Wayne State Univ, Karmanos Canc Ctr, Detroit, MI 48201 USA. [Dean, J. Michael] Univ Utah, Div Crit Care, Dept Pediat, Salt Lake City, UT USA. [Pollack, Murray] Childrens Natl Med Ctr, Washington, DC 20010 USA. [Zimmerman, Jerry] Seattle Childrens Hosp, Seattle, WA USA. [Anand, K. J. S.] Arkansas Childrens Hosp, Little Rock, AR 72202 USA. [Newth, Christopher J. L.] Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA. [Willson, Douglas F.] Univ Virginia, Childrens Hosp, Charlottesville, VA USA. [Nicholson, Carol] NICHHD, Bethesda, MD 20892 USA. RP Meert, KL (reprint author), Wayne State Univ, Dept Pediat, Childrens Hosp Michigan, 3901 Beaubien, Detroit, MI 48201 USA. EM kmeert@med.wayne.edu OI Anand, Kanwaljeet/0000-0001-6498-1483; Eggly, Susan/0000-0002-8137-6098 FU NICHD NIH HHS [U10 HD050096, UG1 HD050096, U10 HD050096-02] NR 33 TC 7 Z9 7 U1 0 U2 3 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1096-6218 J9 J PALLIAT MED JI J. Palliat. Med. PD APR PY 2008 VL 11 IS 3 BP 444 EP 450 DI 10.1089/jpm.2007.0120 PG 7 WC Health Care Sciences & Services SC Health Care Sciences & Services GA 283QO UT WOS:000254651800012 PM 18363487 ER PT J AU Wendler, D AF Wendler, David TI Is it possible to protect pediatric research subjects without blocking appropriate research? SO JOURNAL OF PEDIATRICS LA English DT Editorial Material ID MINIMAL RISK; STANDARD; TRIALS C1 NIH, Dept Bioeth, Bethesda, MD 20892 USA. RP Wendler, D (reprint author), NIH, Dept Bioeth, Bldg 10,Room IC118, Bethesda, MD 20892 USA. EM dwendler@nih.gov FU Intramural NIH HHS [Z99 CL999999] NR 17 TC 8 Z9 8 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 J9 J PEDIATR JI J. Pediatr. PD APR PY 2008 VL 152 IS 4 BP 467 EP 470 DI 10.1016/j.jpeds.2007.09.027 PG 4 WC Pediatrics SC Pediatrics GA 282BS UT WOS:000254543200015 PM 18346497 ER PT J AU Purdy, JB Gafni, RI Reynolds, JC Zeichner, S Hazra, R AF Purdy, Julia B. Gafni, Rachel I. Reynolds, James C. Zeichner, Steven Hazra, Rohan TI Decreased bone mineral density with off-label use of tenofovir in children and adolescents infected with human immunodeficiency virus SO JOURNAL OF PEDIATRICS LA English DT Article ID OPTIMIZED BACKGROUND REGIMEN; DISOPROXIL FUMARATE; ANTIRETROVIRAL AGENTS; SALVAGE THERAPY AB 5 of 6 children infected with human immunodeficiency virus (HIV) receiving Tenofovir disoproxil fumarate (TDF) experienced absolute decreases in bone mineral density (BMD). 2 pre-pubertal subjects experienced > 6% BMD decreases. 1 subject was the smallest child and experienced a 27% decrease, necessitating withdrawal of TDF. Subsequently, her BMD recovered. Monitoring of children infected with HIV who require treatment with TDF is warranted. C1 [Purdy, Julia B.; Gafni, Rachel I.; Zeichner, Steven; Hazra, Rohan] NCI, HIV & AIDS Malignancy Branch, NIH, Bethesda, MD 20892 USA. [Gafni, Rachel I.] Natl Inst Dent & Craniofacial Res, Craniofacial & Skeletal Dis Branch, NIH, Bethesda, MD USA. [Reynolds, James C.] NIH, Warren G Magnuson Clin Ctr, Bethesda, MD 20892 USA. [Hazra, Rohan] NCI, Pediat Oncol Branch, NIH, Bethesda, MD 20892 USA. [Hazra, Rohan] NICHHD, Pediat Adolescent & Maternal AIDS Branch, Bethesda, MD 20892 USA. RP Hazra, R (reprint author), NICHHD, Pediat Adolescent & Maternal AIDS Branch, 6100 Execut Blvd,Room 4B11, Bethesda, MD 20892 USA. EM hazrar@mail.nih.gov FU Intramural NIH HHS [Z99 HD999999] NR 7 TC 67 Z9 70 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 J9 J PEDIATR JI J. Pediatr. PD APR PY 2008 VL 152 IS 4 BP 582 EP 584 DI 10.1016/j.jpeds.2007.12.020 PG 3 WC Pediatrics SC Pediatrics GA 282BS UT WOS:000254543200037 PM 18346519 ER PT J AU Zhao, XB Wu, JM Muthusamy, N Byrd, JC Lee, RJ AF Zhao, Xiaobin Wu, Jianmei Muthusamy, Natarajan Byrd, John C. Lee, Robert J. TI Liposomal coencapsulated fludarabine and mitoxantrone for lymphoproliferative disorder treatment SO JOURNAL OF PHARMACEUTICAL SCIENCES LA English DT Article DE liposomes; nanotechnology; cancer chemotherapy; drug interactions; formulation ID CHRONIC LYMPHOCYTIC-LEUKEMIA; NON-HODGKINS-LYMPHOMA; ADVANCED BREAST-CANCER; ACUTE MYELOID-LEUKEMIA; LOW-GRADE LYMPHOMA; FOLLICULAR LYMPHOMA; ELDERLY-PATIENTS; SYNERGISTIC INTERACTION; INDOLENT LYMPHOMAS; PRIMARY THERAPY AB Fludarabine (FLU)-based combination therapies are commonly used to treat low-grade lymphoma and chronic lymphocytic leukemia (CLL) patients. In vitro and clinical studies have indicated advantages when FLU and mitoxantrone (MTO) are applied in combination. To further enhance this effect, these two agents were coencapsulated. in liposomes. FLU was passively encapsulated during liposome formation, and MTO was loaded with a transmembrane pH gradient. Entrapment efficiency, particle size, stability, and drug release kinetics were characterized. In vitro cytotoxicity study was carried out in two representative B-cell lines: Wac3CD5 and Raji. Synergism as measured by combination index (Cl) was observed in cells treated with liposomes coencapsulating FLU and MTO. Annexin V/propidium iodide (PI) analysis further confirmed that coencapsulated FLU and MTO improved the percentage of apoptosis among primary CLL cells. These data suggest that adopting liposomes containing coencapsulated drug combinations constitutes a potential strategy to promote drug synergism and may have utility in the treatment of leukemia and lymphoma. (C) 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm. Sci 97:1508-1518, 2008. C1 [Zhao, Xiaobin; Wu, Jianmei; Lee, Robert J.] Ohio State Univ, Coll Med, Div Pharmaceut, Columbus, OH 43210 USA. [Zhao, Xiaobin; Muthusamy, Natarajan; Byrd, John C.] Ohio State Univ, Coll Med, Div Hematol Oncol, Columbus, OH 43210 USA. [Muthusamy, Natarajan; Byrd, John C.; Lee, Robert J.] Ohio State Univ, NCI, Ctr Comprehens Canc, Columbus, OH 43210 USA. [Lee, Robert J.] Ohio State Univ, NSF, Ctr Affordable Nanoengn Polymer Biomed Devices, Columbus, OH 43210 USA. RP Byrd, JC (reprint author), Ohio State Univ, Coll Med, Div Pharmaceut, B302 Starling Loving Hall,30 W 10th Ave, Columbus, OH 43210 USA. EM John.Byrd@osumc.edu; lee.1339@osu.edu RI Muthusamy, Natarajan/A-6915-2009 NR 49 TC 9 Z9 9 U1 3 U2 8 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0022-3549 J9 J PHARM SCI-US JI J. Pharm. Sci. PD APR PY 2008 VL 97 IS 4 BP 1508 EP 1518 DI 10.1002/jps.21046 PG 11 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology & Pharmacy SC Pharmacology & Pharmacy; Chemistry GA 280LN UT WOS:000254428400014 PM 17722102 ER PT J AU Woo, AYH Waye, MMY Tsui, SKW Yeung, STW Cheng, CHK AF Woo, Anthony Y. H. Waye, Mary M. Y. Tsui, Stephen K. W. Yeung, Sandy T. W. Cheng, Christopher H. K. TI Andrographolide up-regulates cellular-reduced glutathione level and protects cardiomyocytes against hypoxia/reoxygenation injury SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS LA English DT Article ID ANTIOXIDANT RESPONSE ELEMENT; GENE-EXPRESSION; SUBUNIT GENE; PANICULATA; INDUCTION; ELECTROPHILE; ENZYMES; CARCINOGENESIS; IDENTIFICATION; INFLAMMATION AB Recent studies revealed that the herb Andrographis paniculata possesses cardioprotective activities. Using neonatal rat cardiomyocytes, the cardioprotective actions of several diterpene lactones derived from A. paniculata including andrographolide, 14-deoxyandrographolide, 14-deoxy-11,12-didehydroandrographolide, and sodium 14-deoxyandrographolide-12-sulfonate were investigated. Pretreatment with andrographolide but not with the other compounds protected the cardiomyocytes against hypoxia/reoxygenation injury and up-regulated the cellular-reduced glutathione (GSH) level and antioxidant enzyme activities. The cardioprotective action of andrographolide was found to coincide in a time-dependent manner with the up-regulation of GSH, indicating the important role of GSH. The cardioprotective action of andrographolide was also completely abolished by buthionine sulfoximine, which acts as a specific gamma-glutamate cysteine ligase (GCL) inhibitor to deplete cellular GSH level. It was subsequently found that the mRNA and protein levels of the GCL catalytic subunit (GCLC) and modifier subunit (GCLM) were up-regulated by andrographolide. Luciferase reporter assay also demonstrated that andrographolide activated both the GCLC and the GCLM promoters in the transfected rat H9C2 cardiomyocyte cell line. The 12-O-tetradecanoylphorbo-13-acetate response element or the antioxidant response element may be involved in the transactivating actions of andrographolide on the GCLC and GCLM promoters. The present study pinpoints andrographolide as a cardioprotective principle in A. paniculata and reveals its cytoprotective mechanism. C1 [Woo, Anthony Y. H.] NIA, NIH, Cardiovasc Sci Lab, Baltimore, MD 21224 USA. [Woo, Anthony Y. H.; Waye, Mary M. Y.; Tsui, Stephen K. W.; Yeung, Sandy T. W.; Cheng, Christopher H. K.] Chinese Univ Hong Kong, Dept Biochem, Shatin, Hong Kong, Peoples R China. [Cheng, Christopher H. K.] Chinese Univ Hong Kong, Ctr Novel Funct Mol, Shatin, Hong Kong, Peoples R China. RP Cheng, CHK (reprint author), Chinese Univ Hong Kong, Dept Biochem, Shatin, Hong Kong, Peoples R China. EM chkcheng@cuhk.edu.hk RI Woo, Anthony/D-4305-2014; Waye 韋妙宜教授, Mary Miu Yee /A-9674-2008; Tsui, Stephen Kwok-Wing/E-4385-2015 OI Woo, Anthony/0000-0003-0662-698X; Waye 韋妙宜教授, Mary Miu Yee /0000-0002-2582-4917; Tsui, Stephen Kwok-Wing/0000-0003-0686-4259 NR 40 TC 53 Z9 58 U1 2 U2 10 PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA SN 0022-3565 EI 1521-0103 J9 J PHARMACOL EXP THER JI J. Pharmacol. Exp. Ther. PD APR PY 2008 VL 325 IS 1 BP 226 EP 235 DI 10.1124/jpet.107.133918 PG 10 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 275IJ UT WOS:000254064800025 PM 18174384 ER PT J AU Avninder, S Ylaya, K Hewitt, SM AF Avninder, S. Ylaya, K. Hewitt, S. M. TI Tissue microarray: A simple technology that has revolutionized research in pathology SO JOURNAL OF POSTGRADUATE MEDICINE LA English DT Review DE high-throughput; immunohistochemistry; pathology; proteomics; tissue microarray ID PROSTATE-CANCER; EXPRESSION; CARCINOMA; PLATFORM AB Tissue microarray (TMA) technology is a high-throughput research tool, which has greatly facilitated and accelerated tissue analyses by in-situ technologies. TMAs are amenable to every research method that can be applied on the standard whole sections at enhanced speed. It plays a central role in target verification of results from cDNA arrays, expression profiling of tumors and tissues, and is proving to be a powerful platform for proteomic research. In this review article, primarily meant for students of pathology and oncology, we briefly discuss its basic methodology, applications and merits and limitations. C1 [Avninder, S.] Inst Pathol ICMR, New Delhi, India. [Ylaya, K.; Hewitt, S. M.] NCI, Tissue Array Res Program, Pathol Lab, Ctr Canc Res,NIH, Bethesda, MD 20892 USA. RP Avninder, S (reprint author), Inst Pathol ICMR, New Delhi, India. EM dravninder@yahoo.co.in OI Hewitt, Stephen/0000-0001-8283-1788 NR 27 TC 29 Z9 32 U1 0 U2 2 PU MEDKNOW PUBLICATIONS PI MUMBAI PA A-108-109 KANARA BUSINESS CENTRE, GHAKTOPAR, MUMBAI, 400075, INDIA SN 0022-3859 J9 J POSTGRAD MED JI J. Postgrad. Med. PD APR-JUN PY 2008 VL 54 IS 2 BP 158 EP 162 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 310EQ UT WOS:000256512100026 PM 18480540 ER PT J AU Wulfkuhle, JD Speer, R Pierobon, M Laird, J Espina, V Deng, J Mammano, E Yang, SX Swain, SM Nitti, D Esserman, LJ Belluco, C Liotta, LA Petricoin, EF AF Wulfkuhle, Julia D. Speer, Runa Pierobon, Mariaelena Laird, Julie Espina, Virginia Deng, Jianghong Mammano, Enzo Yang, Sherry X. Swain, Sandra M. Nitti, Donato Esserman, Laura J. Belluco, Claudio Liotta, Lance A. Petricoin, Emanuel F., III TI Multiplexed cell signaling analysis of human breast cancer applications for personalized therapy SO JOURNAL OF PROTEOME RESEARCH LA English DT Article DE breast cancer; proteomics; cell signaling; phosphoproteomics; tailored therapy; protein microarray ID PHASE PROTEIN MICROARRAYS; LASER-CAPTURE MICRODISSECTION; TARGETED THERAPIES; ESTROGEN-RECEPTOR; PROSTATE-CANCER; CLINICAL-APPLICATIONS; COMBINATION THERAPY; MOLECULAR MEDICINE; PROTEOMIC ANALYSIS; ENDOCRINE THERAPY AB Phosphoprotein driven cellular signaling events represent most of the new molecular targets for cancer treatment. Application of reverse-phase protein microarray technology for the study of ongoing signaling activity within breast tumor specimens holds great potential for elucidating and profiling signaling activity in real-time for patient-tailored therapy. Analysis of laser capture microdissection primary human breast tumors and metastatic lesions reveals pathway specific profiles and a new way to classify cancer based on functional signaling portraits. Moreover, the data demonstrate the requirement of laser capture microdissection for analysis and reveal the metastasis-specific changes that occur within a new microenvironment. Analysis of biopsy material from clinical trials for targeted therapeutics demonstrates the feasibility and utility of comprehensive signal pathway activation profiling for molecular analysis. C1 [Wulfkuhle, Julia D.; Pierobon, Mariaelena; Espina, Virginia; Deng, Jianghong; Liotta, Lance A.; Petricoin, Emanuel F., III] George Mason Univ, Ctr Appl Proteom & Mol Med, Manassas, VA 20110 USA. [Speer, Runa] NCI, Pathol Lab, Ctr Canc Res, Natl Inst Hlth, Bethesda, MD 20892 USA. [Speer, Runa] Univ Tubingen, Dept Obstet & Gynecol, D-72076 Tubingen, Germany. [Laird, Julie; Esserman, Laura J.] Univ Calif San Francisco, Sch Med, Dept Surg, San Francisco, CA 94115 USA. [Mammano, Enzo; Nitti, Donato] Univ Padua, Dept Oncol & Surg Sci, I-35128 Padua, Italy. [Yang, Sherry X.; Swain, Sandra M.] Natl Canc Inst, Canc Therapeut Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. [Belluco, Claudio] Natl Canc Inst, CRO IRCCS, I-33081 Aviano, Italy. RP Petricoin, EF (reprint author), George Mason Univ, Ctr Appl Proteom & Mol Med, 10900 Univ Blvd,MS 4E3, Manassas, VA 20110 USA. EM epetrico@gmu.edu OI belluco, claudio/0000-0001-5972-9574; Espina, Virginia/0000-0001-5080-5972; Swain, Sandra/0000-0002-1320-3830 NR 72 TC 93 Z9 94 U1 0 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1535-3893 J9 J PROTEOME RES JI J. Proteome Res. PD APR PY 2008 VL 7 IS 4 BP 1508 EP 1517 DI 10.1021/pr7008127 PG 10 WC Biochemical Research Methods SC Biochemistry & Molecular Biology GA 284MR UT WOS:000254711000016 PM 18257519 ER PT J AU Pincus, SM Schmidt, PJ Palladino-Negro, P Rubinow, DR AF Pincus, Steven M. Schmidt, Peter J. Palladino-Negro, Paula Rubinow, David R. TI Differentiation of women with premenstrual dysphoric disorder, recurrent brief depression, and healthy controls by daily mood rating dynamics SO JOURNAL OF PSYCHIATRIC RESEARCH LA English DT Article DE mood disorders; premenstrual dysphoric disorder; premenstrual syndrome; recurrent brief depression; approximate entropy; spikiness ID APPROXIMATE ENTROPY; RESPIRATORY IRREGULARITY; LUTEINIZING-HORMONE; NONLINEAR MEASURES; PANIC DISORDER; MENSTRUAL-CYCLE; SYMPTOMS; EPIDEMIOLOGY; REGULARITY; PULSATILITY AB Enhanced statistical characterization of mood-rating data holds the potential to more precisely classify and sub-classify recurrent mood disorders like premenstrual dysphoric disorder (PMDD) and recurrent brief depressive disorder (RBD). We applied several complementary statistical methods to differentiate mood rating dynamics among women with PMDD, RBD, and normal controls (NC). We compared three subgroups of women: NC (n = 8); PMDD (n = 15); and RBD (n = 9) on the basis of daily self-ratings of sadness, study lengths between 50 and 120 days. We analyzed mean levels; overall variability, SD; sequential irregularity, approximate entropy (ApEn); and a quantification of the extent of brief and staccato dynamics, denoted 'Spikiness'. For each of SD, irregularity (ApEn), and Spikiness, we showed highly significant subgroup differences, ANOVA <= 0.001 for each statistic; additionally, many paired subgroup comparisons showed highly significant differences. In contrast, mean levels were indistinct among the subgroups. For SD, normal controls had much smaller levels than the other subgroups, with RBD intermediate. ApEn showed PMDD to be significantly more regular than the other subgroups. Spikiness showed NC and RBD data sets to be much more staccato than their PMDD counterparts, and appears to suitably characterize the defining feature of RBD dynamics. Compound criteria based on these statistical measures discriminated diagnostic subgroups with high sensitivity and specificity. Taken together, the statistical suite provides well-defined specifications of each subgroup. This can facilitate accurate diagnosis, and augment the prediction and evaluation of response to treatment. The statistical methodologies have broad and direct applicability to behavioral studies for many psychiatric disorders, and indeed to similar analyses of associated biological signals across multiple axes. (C) 2007 Elsevier Ltd. All rights reserved. C1 [Schmidt, Peter J.; Palladino-Negro, Paula; Rubinow, David R.] NIMH, Behav Endocrinol Branch, Bethesda, MD 20892 USA. RP Pincus, SM (reprint author), 990 Moose Hill Rd, Guilford, CT 06437 USA. EM stevepincus@alum.mit.edu NR 50 TC 20 Z9 21 U1 0 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-3956 J9 J PSYCHIATR RES JI J. Psychiatr. Res. PD APR PY 2008 VL 42 IS 5 BP 337 EP 347 DI 10.1016/j.jpsychires.2007.01.001 PG 11 WC Psychiatry SC Psychiatry GA 284QN UT WOS:000254721000001 PM 17336329 ER PT J AU Fee, E Parry, M AF Fee, Elizabeth Parry, Manon TI Jonathan Mann, HIV/AIDS, and human rights SO JOURNAL OF PUBLIC HEALTH POLICY LA English DT Article; Proceedings Paper CT 134th Annual Meeting of the American-Public-Health-Association CY NOV 04-08, 2006 CL Boston, MA SP Amer Public Hlth Assoc DE AIDS; health; human rights; Jonathan Mann; World Health Organization AB The early association of HIV/AIDS with marginal groups - homosexuals and IV drug users - structured social and political responses to the disease. Many countries began to enact restrictive travel policies and to contemplate compulsory testing or quarantine for those infected. In Africa, Jonathan Mann became convinced that the disease was heterosexually transmitted and had the potential to become a worldwide pandemic. He convinced Halfden Mahler, Director General of WHO, who appointed him director of the WHO's Global Programme on AIDS. In this position, and because of his eloquence and passion, Mann was able to mobilize ministers of health around the world. Mann argued that AIDS was a social disease, flourishing in conditions of poverty, oppression, urban migration, gender inequality, and violence. He advanced a new way of understanding AIDS and AIDS policies based on a human rights framework. C1 [Parry, Manon] Univ Maryland, Bethesda, MD 20742 USA. [Fee, Elizabeth] Natl Lib Med, Natl Inst Hlth, Bethesda, MD USA. RP Fee, E (reprint author), Univ Maryland, 1102 Holzapfel Hall Coll Pk, Bethesda, MD 20742 USA. EM feee@mail.nih.gov; mparry@umd.edu NR 46 TC 16 Z9 16 U1 1 U2 4 PU PALGRAVE MACMILLAN LTD PI BASINGSTOKE PA BRUNEL RD BLDG, HOUNDMILLS, BASINGSTOKE RG21 6XS, HANTS, ENGLAND SN 0197-5897 J9 J PUBLIC HEALTH POL JI J. Public Health Policy PD APR PY 2008 VL 29 IS 1 BP 54 EP 71 DI 10.1057/palgrave.jphp.3200160 PG 18 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA 280ZK UT WOS:000254465400007 PM 18368019 ER PT J AU Wakitani, S Hondo, E Phichitraslip, T Stewart, CL Kiso, Y AF Wakitani, Shoichi Hondo, Eiichi Phichitraslip, Thanmaporn Stewart, Colin Lawson Kiso, Yasuo TI Upregulation of Indian hedgehog gene in the uterine epithelium by leukemia inhibitory factor during mouse implantation SO JOURNAL OF REPRODUCTION AND DEVELOPMENT LA English DT Article DE embryo implantation; Indian hedgehog; leukemia inhibitory factor (LIF); mouse; progesterone receptor; uterine luminal epithelium ID BLASTOCYST IMPLANTATION; EMBRYO IMPLANTATION; STAT3 ACTIVATION; UTERUS; EXPRESSION; RECEPTOR; PROTEIN; ESTROGEN; MICE; ACYLTRANSFERASE AB Leukemia inhibitory factor (LIF) and Indian hedgehog (Ihh) are essential for embryo implantation in mice and are regulated by the actions of 17 beta-estradiol (E2) and progesterone, respectively. The present study examined the effect of LIF on Ihh and Ihh-related factors in the uterine luminal epithelium during the implantation period using a DNA microarray. Expression of Ihh mRNA reached its peak on the forth day of pregnancy, and progesterone receptor (Pgr) mRNA decreased on the fifth day of pregnancy in wildtype mice. On the other hand, these changes in expression were not seen in LIF-/- mice. Ihh and Pgr mRNA were upregulated by LIF injection in delayed implantation mice. This upregulation of Pgr was transient and preceded an increase of Ihh mRNA. Ihh mRNA also increased after E2 injection in delayed implantation mice of the LIF-/- genotype. E2 did not affect transcription of Pgr mRNA in the uterine luminal epithelium of delayed implantation LIF-/- mice. Using an antibody against the C-terminal epitope of Ihh, unprocessed Ihh proteins, but not C-terminal peptides, by autoproteolytic cleavage of Ihh were detected by western blot analysis. Unprocessed Ihh did not show quantitative changes between the wildtype and LIF-/- mice during the implantation period. Transcription of hedgehog acyltransferase was not influenced by LIF and E2 injection. In conclusion, LIF, which has a crucial role in E2 action for initiation of implantation, caused transient induction of Pgr mRNA and subsequent upregulation of Ihh mRNA, which mediates progesterone-Pgr actions for successful implantation. C1 [Wakitani, Shoichi; Hondo, Eiichi; Kiso, Yasuo] Yamaguchi Univ, Fac Agr, Dept Vet Anat, Yamaguchi 7538511, Japan. [Hondo, Eiichi; Phichitraslip, Thanmaporn; Kiso, Yasuo] Yamaguchi Univ, United Grad Sch Vet Sci, Lab Basic Vet Sci, Yamaguchi 7538511, Japan. [Stewart, Colin Lawson] NCI, Canc & Dev Biol Lab, Frederick, MD 21702 USA. RP Hondo, E (reprint author), Yamaguchi Univ, Fac Agr, Dept Vet Anat, Yamaguchi 7538511, Japan. EM ehondo@yamaguchi-u.ac.jp NR 29 TC 23 Z9 23 U1 0 U2 0 PU SOCIETY REPRODUCTION & DEVELOPMENT-SRD PI TSUKUBA PA C/O KAZUHIRO KIKUCHI, PHD DVM, NATL INST AGROBIOLOGICAL SCIENCES KANNONDAI 2-1-2, TSUKUBA, IBARAKI 305-8602, JAPAN SN 0916-8818 J9 J REPROD DEVELOP JI J. Reprod. Dev. PD APR PY 2008 VL 54 IS 2 BP 113 EP 116 DI 10.1262/jrd.19120 PG 4 WC Agriculture, Dairy & Animal Science; Reproductive Biology SC Agriculture; Reproductive Biology GA 293BT UT WOS:000255310500004 PM 18239353 ER PT J AU Han, QB Wong, L Yang, NY Song, JZ Qiao, CF Yiu, H Ito, Y Xu, HX AF Han, Quan-Bin Wong, Lina Yang, Nian-Yun Song, Jing-Zheng Qiao, Chun-Feng Yiu, Hillary Ito, Yoichiro Xu, Hong-Xi TI A simple method to optimize the HSCCC two-phase solvent system by predicting the partition coefficient for target compound SO JOURNAL OF SEPARATION SCIENCE LA English DT Article DE high-speed counter-current chromatography; partition coefficient; preparative isolation; Pseudolarix kaempferi Gordon (Pinaceae); pseudolaric acid B ID COUNTER-CURRENT CHROMATOGRAPHY; PSEUDOLARIC ACID-B; PREPARATIVE ISOLATION; PURIFICATION; KAEMPFERI; SELECTION; HERB; CCC AB A simple method was developed to optimize the solvent ratio of the two-phase solvent system used in the high-speed counter-current chromatography (HSCCC) separation. Some mathematic equations, such as the exponential and the power equations, were established to describe the relationship between the solvent ratio and the partition coefficient. Using this new method, the two-phase solvent system was easily optimized to obtain a proper partition coefficient for the CCC separation of the target compound. Furthermore, this method was satisfactorily applied in determining the two-phase solvent system for the HSCCC preparation of pseudolaric acid B from the Chinese herb Pseudolarix kaempferi Gordon (Pinaceae). The two-phase solvent system of n-hexane/EtOAc/MeOH/H2O (5:5:5:5 by volume) was used with a good partition coefficient K = 1.08. As a result, 232.05 mg of pseudolaric acid B was yielded from 0.5 g of the crude extract with a purity of 97.26% by HPLC analysis. C1 [Han, Quan-Bin; Wong, Lina; Yang, Nian-Yun; Song, Jing-Zheng; Qiao, Chun-Feng; Yiu, Hillary; Xu, Hong-Xi] Hong Kong Jockey Club Inst Chinese Med, Bioinformat Ctr, Chinese Med Lab, Hong Kong, Hong Kong, Peoples R China. [Ito, Yoichiro] NHLBI, Ctr Biochem & Biophys, Natl Inst Hlth, Bethesda, MD USA. RP Xu, HX (reprint author), Hong Kong Jockey Club Inst Chinese Med, Bioinformat Ctr, Chinese Med Lab, Unit 703,7th Floor,2 Sci Pk W Ave,Hong Kong Sci P, Hong Kong, Hong Kong, Peoples R China. EM xuhongxi@hkjcicm.org NR 18 TC 26 Z9 27 U1 2 U2 16 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 1615-9306 J9 J SEP SCI JI J. Sep. Sci. PD APR PY 2008 VL 31 IS 6-7 BP 1189 EP 1194 DI 10.1002/jssc.200700582 PG 6 WC Chemistry, Analytical SC Chemistry GA 297JU UT WOS:000255613800037 PM 18306210 ER PT J AU Lowell, SY Barkmeier-Kraemer, JM Hoit, JD Story, BH AF Lowell, Soren Y. Barkmeier-Kraemer, Julie M. Hoit, Jeannette D. Story, Brad H. TI Respiratory and laryngeal function during spontaneous speaking in teachers with voice disorders SO JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH LA English DT Article DE voice; voice disorders; respiratory system; larynx ID RANDOMIZED CLINICAL-TRIAL; LUNG-VOLUME INITIATION; VOCAL FATIGUE; RIB CAGE; SUPRAGLOTTIC ACTIVITY; INTENSITY VARIATION; GENERAL-POPULATION; OBJECTIVE MEASURES; SPEECH PRODUCTION; CONNECTED SPEECH AB Purpose: To determine if respiratory and laryngeal function during spontaneous speaking were different for teachers with voice disorders compared with teachers without voice problems. Method: Eighteen teachers, 9 with and 9 without voice disorders, were included in this study. Respiratory function was measured with magnetometry, and laryngeal function was measured with electroglottography during 3 spontaneous speaking tasks: a simulated teaching task at a typical loudness level, a simulated teaching task at an increased loudness level, and a conversational speaking task. Electroglottography measures were also obtained for 3 structured speaking tasks: a paragraph reading task, a sustained vowel, and a maximum phonation time vowel. Results: Teachers with voice disorders started and ended their breath groups at significantly smaller lung volumes than teachers without voice problems during teaching-related speaking tasks; however, there were no between-group differences in laryngeal measures. Task-related differences were found on several respiratory measures and on one laryngeal measure. Conclusions: These findings suggest that teachers with voice disorders used different speech breathing strategies than teachers without voice problems. Implications for clinical management of teachers with voice disorders are discussed. C1 [Lowell, Soren Y.] Natl Inst Neurol Disorders & Stroke, Laryngeal & Speech Sect, NIH, Bethesda, MD 20892 USA. [Barkmeier-Kraemer, Julie M.; Hoit, Jeannette D.; Story, Brad H.] Univ Arizona, Tucson, AZ USA. RP Lowell, SY (reprint author), Natl Inst Neurol Disorders & Stroke, Laryngeal & Speech Sect, NIH, Bethesda, MD 20892 USA. EM lowells@ninds.nih.gov NR 83 TC 12 Z9 13 U1 2 U2 5 PU AMER SPEECH-LANGUAGE-HEARING ASSOC PI ROCKVILLE PA 10801 ROCKVILLE PIKE, ROCKVILLE, MD 20852-3279 USA SN 1092-4388 J9 J SPEECH LANG HEAR R JI J. Speech Lang. Hear. Res. PD APR 1 PY 2008 VL 51 IS 2 BP 333 EP 349 DI 10.1044/1092-4388(2008/025) PG 17 WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation GA 281WN UT WOS:000254529700003 PM 18367681 ER PT J AU Ghosh, K Tiwari, RC AF Ghosh, Kaushik Tiwari, Ram C. TI Estimating the distribution function using k-tuple ranked set samples SO JOURNAL OF STATISTICAL PLANNING AND INFERENCE LA English DT Article DE empirical process; extreme ranked set sample; cost of sampling; imperfect ranking ID EXTREME AB The basic assumption underlying the concept of ranked set sampling is that actual measurement of units is expensive, whereas ranking is cheap. This may not be true in reality in certain cases where ranking may be moderately expensive. in such situations, based on total cost considerations, k-tuple ranked set sampling is known to be a viable alternative, where one selects k units (instead of one) from each ranked set. In this article, we consider estimation of the distribution function based on k-tuple ranked set samples when the cost of selecting and ranking units is not ignorable. We investigate estimation both in the balanced and unbalanced data case. Properties of the estimation procedure in the presence of ranking error are also investigated. Results of simulation studies as well as an application to a real data set are presented to illustrate some of the theoretical findings. (C) 2007 Elsevier B.V. All rights reserved. C1 [Ghosh, Kaushik] New Jersey Inst Technol, Dept Math Sci, Newark, NJ 07102 USA. [Tiwari, Ram C.] NCI, Bethesda, MD 20892 USA. RP Ghosh, K (reprint author), New Jersey Inst Technol, Dept Math Sci, Newark, NJ 07102 USA. EM ghoshl@verizon.net NR 19 TC 4 Z9 4 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3758 J9 J STAT PLAN INFER JI J. Stat. Plan. Infer. PD APR 1 PY 2008 VL 138 IS 4 BP 929 EP 949 DI 10.1016/j.spi.2007.02.012 PG 21 WC Statistics & Probability SC Mathematics GA 262XL UT WOS:000253181600010 ER PT J AU Sousa, AA Hohmann-Marriott, M Aronova, MA Zhang, G Leapman, RD AF Sousa, A. A. Hohmann-Marriott, M. Aronova, M. A. Zhang, G. Leapman, R. D. TI Determination of quantitative distributions of heavy-metal stain in biological specimens by annular dark-field STEM SO JOURNAL OF STRUCTURAL BIOLOGY LA English DT Article DE scanning transmission electron microscopy; STEM; elastic scattering; cross sections; electron tomography; gold clusters; immunolabeling; heavy-metal staining ID TRANSMISSION ELECTRON-MICROSCOPY; CRYOELECTRON MICROSCOPY; VITREOUS SECTIONS; TOMOGRAPHY; CELLS; IMMUNOCYTOCHEMISTRY; MACROMOLECULES; SPECTROSCOPY; CONTRAST; LABELS AB It is shown that dark-field images collected in the scanning transmission electron microscope (STEM) at two different camera lengths yield quantitative distributions of both the heavy and light atoms in a stained biological specimen. Quantitative analysis of the paired STEM images requires knowledge of the elastic scattering cross sections, which are calculated from the NIST elastic scattering cross section database. The results reveal quantitative information about the distribution of fixative and stain within the biological matrix, and provide a basis for assessing detection limits for heavy-metal clusters used to label intracellular proteins. In sectioned cells that have been stained only with osmium tetroxide, we find an average of 1.2 +/- 0.1 Os atom per nm(3), corresponding to an atomic ratio of Os:C atoms of approximately 0.02, which indicates that small heavy atom clusters of Undecagold and Nanogold can be detected in lightly stained specimens. Published by Elsevier Inc. C1 [Sousa, A. A.; Hohmann-Marriott, M.; Aronova, M. A.; Zhang, G.; Leapman, R. D.] Natl Inst Biomed Imaging & Bioengn, NIH, Lab Bioengn & Phys Sci, Bethesda, MD 20892 USA. RP Leapman, RD (reprint author), Natl Inst Biomed Imaging & Bioengn, NIH, Lab Bioengn & Phys Sci, Bldg 13,Room 3N17,13 S Dr, Bethesda, MD 20892 USA. EM leapmanr@mail.nih.gov FU Intramural NIH HHS [Z01 EB000046-01] NR 43 TC 21 Z9 21 U1 1 U2 7 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1047-8477 J9 J STRUCT BIOL JI J. Struct. Biol. PD APR PY 2008 VL 162 IS 1 BP 14 EP 28 DI 10.1016/j.jsb.2008.01.007 PG 15 WC Biochemistry & Molecular Biology; Biophysics; Cell Biology SC Biochemistry & Molecular Biology; Biophysics; Cell Biology GA 292WA UT WOS:000255295600002 PM 18359249 ER PT J AU Waters, AM Mogg, K Bradley, BP Pine, DS AF Waters, Allison M. Mogg, Karin Bradley, Brendan P. Pine, Daniel S. TI Attentional bias for emotional faces in children with generalized anxiety disorder SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY LA English DT Article DE attentional bias; anxiety disorders ID THREATENING FACIAL EXPRESSIONS; SELECTIVE ATTENTION; DEPRESSIVE DISORDER; SOCIAL PHOBIA; ANGRY FACES; ADOLESCENTS; INFORMATION; PSYCHOPATHOLOGY; CHILDHOOD; STRESS AB Objective: To examine attentional bias for angry and happy faces in 7- to 12-year-old children with generalized anxiety disorder (GAD; n = 23) and nonanxious controls (n = 25). Method: Children completed a visual probe task in which pairs of face stimuli were displayed for 500 milliseconds and were replaced by a visual probe in the spatial location of one of the faces. Results: Severely anxious children with GAD showed an attentional bias toward both angry and happy faces. Children with GAD with a milder level of anxiety and nonanxious controls did not show an attentional bias toward emotional faces. Moreover, within the GAD group, attentional bias for angry faces was associated with increased anxiety severity and the presence of social phobia. Conclusions: Biased attention toward threat as a function of increased severity in pediatric GAD may reflect differing threat appraisal processes or emotion regulation strategies. C1 [Waters, Allison M.] Griffith Univ, Sch Psychol, Southport, Qld 4222, Australia. [Mogg, Karin; Bradley, Brendan P.] Univ Southampton, Sch Psychol, Ctr Study Emot & Motivat, Southampton SO9 5NH, Hants, England. [Pine, Daniel S.] NIMH, NIH, Sect Dev & Affect Neurosci, Bethesda, MD USA. RP Waters, AM (reprint author), Griffith Univ, Sch Psychol, Gold Coast Campus, Southport, Qld 4222, Australia. EM a.waters@griffith.edu.au RI Mogg, Karin/C-1181-2008; Bradley, Brendan/B-9724-2008; OI Mogg, Karin/0000-0002-2738-7378; Bradley, Brendan/0000-0003-2801-4271; Waters, Allison/0000-0003-2453-793X NR 36 TC 84 Z9 85 U1 10 U2 44 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0890-8567 J9 J AM ACAD CHILD PSY JI J. Am. Acad. Child Adolesc. Psychiatr. PD APR PY 2008 VL 47 IS 4 BP 435 EP 442 DI 10.1097/CHI.0b013e3181642992 PG 8 WC Psychology, Developmental; Pediatrics; Psychiatry SC Psychology; Pediatrics; Psychiatry GA 278EF UT WOS:000254266100012 PM 18388762 ER PT J AU Garcia, I Tabak, LA AF Garcia, Isabel Tabak, Lawrence A. TI Beyond the "omics" - Translating science into improved health SO JOURNAL OF THE AMERICAN DENTAL ASSOCIATION LA English DT Editorial Material ID BREAST-CANCER C1 [Garcia, Isabel; Tabak, Lawrence A.] Natl Inst Dent & Craniofacial Res, Bethesda, MD 20892 USA. RP Garcia, I (reprint author), Natl Inst Dent & Craniofacial Res, 31 Ctr Dr Bldg 31,Room 2C39, Bethesda, MD 20892 USA. EM GarciaI@mail.nih.gov FU Intramural NIH HHS [Z99 OD999999] NR 5 TC 3 Z9 3 U1 0 U2 1 PU AMER DENTAL ASSOC PI CHICAGO PA 211 E CHICAGO AVE, CHICAGO, IL 60611 USA SN 0002-8177 J9 J AM DENT ASSOC JI J. Am. Dent. Assoc. PD APR PY 2008 VL 139 IS 4 BP 392 EP + PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 286YA UT WOS:000254881300001 PM 18385018 ER PT J AU Deshpande, N Metter, EJ Lauretani, F Bandinelli, S Guralnik, J Ferrucci, L AF Deshpande, Nandini Metter, E. Jeffrey Lauretani, Fulvio Bandinelli, Stefania Guralnik, Jack Ferrucci, Luigi TI Activity restriction induced by fear of falling and objective and subjective measures of physical function: A prospective cohort study SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Article DE fear of falling; activity restriction; aging; disability; physical function ID LOWER-EXTREMITY FUNCTION; LIVING OLDER-PEOPLE; ELDERLY PERSONS; SUBSEQUENT DISABILITY; COMMUNITY; AVOIDANCE; INCHIANTI; PERFORMANCE; PREVALENCE; FRAILTY AB OBJECTIVES: To examine whether activity restriction specifically induced by fear of falling (FF) contributes to greater risk of disability and decline in physical function. DESIGN: Prospective cohort study. SETTING: Population-based older cohort. PARTICIPANTS: Six hundred seventy-three community-living elderly (>= 65) participants in the Invecchiare in Chianti Study who reported FF. MEASUREMENTS: FF, fear-induced activity restriction, cognition, depressive symptoms, comorbidities, smoking history, and demographic factors were assessed at baseline. Disability in activities of daily living (ADLs) and instrumental activities of daily living (IADLs) and performance on the Short Performance Physical Battery (SPPB) were evaluated at baseline and at the 3-year follow-up. RESULTS: One-quarter (25.5%) of participants did not report any activity restriction, 59.6% reported moderate activity restriction (restriction or avoidance of <3 activities), and 14.9% reported severe activity restriction (restriction or avoidance of >= 3 activities). The severe restriction group reported significantly higher IADL disability and worse SPPB scores than the no restriction and moderate restriction groups. Severe activity restriction was a significant independent predictor of worsening ADL disability and accelerated decline in lower extremity performance on SPPB over the 3-year follow-up. Severe and moderate activity restriction were independent predictors of worsening IADL disability. Results were consistent even after adjusting for multiple potential confounders. CONCLUSION: In an elderly population, activity restriction associated with FF is an independent predictor of decline in physical function. Future intervention studies in geriatric preventive care should directly address risk factors associated with FF and activity restriction to substantiate long-term effects on physical abilities and autonomy of older persons. C1 [Deshpande, Nandini] Univ Kansas, Dept Phys Theraphy & Rehabil Sci, Med Ctr, Kansas City, KS 66160 USA. [Metter, E. Jeffrey; Ferrucci, Luigi] NIA, Longitudinal Studies Sect, Clin Res Branch, Baltimore, MD 21224 USA. [Lauretani, Fulvio] Tuscany Reg Hlth Agcy, Florence, Italy. [Bandinelli, Stefania] Azienda Sanitaria Firenze, Geriatr Rehabil Unit, Florence, Italy. [Guralnik, Jack] NIA, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA. RP Deshpande, N (reprint author), Univ Kansas, Dept Phys Theraphy & Rehabil Sci, Med Ctr, MS 2002 3901 Rainbow Blvd, Kansas City, KS 66160 USA. EM ndeshpande@kumc.edu RI Lauretani, Fulvio/K-5115-2016 OI Lauretani, Fulvio/0000-0002-5287-9972 FU Intramural NIH HHS [Z99 AG999999]; NIA NIH HHS [N01-AG-5-0002, N01-AG-821336, N01-AG-916413, R01 AG027012] NR 25 TC 99 Z9 104 U1 4 U2 23 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-8614 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2008 VL 56 IS 4 BP 615 EP 620 DI 10.1111/j.1532-5415.2007.01639.x PG 6 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA 282IX UT WOS:000254562200004 PM 18312314 ER PT J AU Volpato, S Ble, A Metter, EJ Lauretani, F Bandinelli, S Zuliani, G Fellin, R Ferrucci, L Guralnik, JM AF Volpato, Stefano Ble, Alessandro Metter, E. Jeffrey Lauretani, Fulvio Bandinelli, Stefania Zuliani, Giovanni Fellin, Renato Ferrucci, Luigi Guralnik, Jack M. TI High-density lipoprotein cholesterol and objective measures of lower extremity performance in older nondisabled persons: The InChianti study SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Article DE HDL-C; cytokines; aging; disablement process; strength ID NITRIC-OXIDE SYNTHASE; MOBILITY LIMITATION; BODY-COMPOSITION; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; PHYSICAL-ACTIVITY; HDL CHOLESTEROL; AGE; ASSOCIATION; DISABILITY AB OBJECTIVES: To evaluate the independent association between high-density lipoprotein cholesterol (HDL-C) levels and objective measures of lower extremity performance. DESIGN: Cross-sectional cohort study. SETTING: Community-based. PARTICIPANTS: Eight hundred thirty-six nondisabled women and men aged 65 and older enrolled in the Invecchiare in Chianti study. MESASUREMENTS: Lower extremity performance was assessed using 4-m walking speed at fast pace, 400-m walking speed, and knee extension torque. Fasting HDL-C levels were determined using commercial enzymatic tests. RESULTS: The mean age of participants was 73.7 (65-92), and 55.6% were women. After adjusting for potential confounders (sociodemographic factors, smoking, physical activity, body composition, and clinical conditions including cardiovascular and cerebrovascular disease, inflammatory markers, and serum testosterone) HDL-C levels were significantly associated with knee extension torque in men and women and with 4-m and 400-m walking speed in men. Men in the highest tertile of the HDL-C distribution (> 55 mg/dL) had, on average, a three times greater probability of belonging to the best tertile of all indexes of lower extremity performance, including 4-m fast walking speed (odds ratio (OR)=2.57, 95%=confidence interval (CI)=1.07-6.17), 400-m walking speed (OR=3.74, 95% CI=1.20-11.7), and knee extension torque (OR=3.63, 95%=CI 1.41-9.33). Path analysis suggested a direct relationship between HDL-C and knee extension torque. In older nondisabled persons, HDL-C levels are highly correlated with knee extension torque and walking speed. Further research should focus on the biological mechanism of this association. C1 [Volpato, Stefano; Zuliani, Giovanni; Fellin, Renato] Univ Ferrara, Dept Clin & Expt Med, Sect Internal Med & Geriatr, I-44100 Ferrara, Italy. [Ble, Alessandro; Metter, E. Jeffrey; Ferrucci, Luigi] NIA, Longitudinal Studies Sect, Clin Res Branch, Baltimore, MD 21224 USA. [Lauretani, Fulvio] Tuscany Reg Hlth Agcy, Florence, Italy. [Bandinelli, Stefania] Azienda Sanitaria Firenze, Geriat Rehabil Unit, Florence, Italy. [Guralnik, Jack M.] NIA, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA. RP Volpato, S (reprint author), Univ Ferrara, Dept Clin & Expt Med, Sect Internal Med & Geriatr, Via Savonarola 9, I-44100 Ferrara, Italy. EM vlt@unife.it RI VOLPATO, STEFANO/H-2977-2014; Lauretani, Fulvio/K-5115-2016 OI VOLPATO, STEFANO/0000-0003-4335-6034; Lauretani, Fulvio/0000-0002-5287-9972 FU Intramural NIH HHS [Z99 AG999999] NR 41 TC 14 Z9 14 U1 1 U2 2 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-8614 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2008 VL 56 IS 4 BP 621 EP 629 DI 10.1111/j.1532-5415.2007.01608.x PG 9 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA 282IX UT WOS:000254562200005 PM 18205758 ER PT J AU Koster, A Patel, KV Visser, M Van Eijk, JTM Kanaya, AM De Rekeneire, N Newman, AB Tylavsky, FA Kritchevsky, SB Harris, TB AF Koster, Annemarie Patel, Kushang V. Visser, Marjolein Van Eijk, Jacques Th. M. Kanaya, Alka M. De Rekeneire, Nathalie Newman, Anne B. Tylavsky, Frances A. Kritchevsky, Stephen B. Harris, Tamara B. CA Hlth Aging Body Composition Study TI Joint effects of adiposity and physical activity on incident mobility limitation in older adults SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Article DE adiposity; obesity; physical activity; physical function; aged ID BODY-MASS INDEX; CARDIOVASCULAR-DISEASE MORTALITY; LIFE-STYLE INTERVENTION; CORONARY-HEART-DISEASE; CARDIORESPIRATORY FITNESS; WEIGHT CHANGE; RISK-FACTORS; ELDERLY-MEN; ALL-CAUSE; OBESITY AB OBJECTIVES: To examine joint associations of physical activity and adiposity measures (body mass index (BMI), waist circumference, percentage body fat) with incident mobility limitation. DESIGN: Prospective observational cohort study. SETTING: Memphis, Tennessee and Pittsburgh, Pennsylvania. PARTICIPANTS: Two thousand nine hundred and eighty-two black and white men and women aged 70 to 79 participating in the Health, Aging and Body Composition (Health ABC) study. MEASUREMENTS: Mobility limitation was defined as reported difficulty walking one-quarter of a mile or climbing 10 steps during two consecutive semiannual assessments over 6.5 years. Three measures of adiposity were included in this study: BMI, total percentage body fat, and waist circumference. Physical activity was assessed using a modified leisure-time physical activity questionnaire. RESULTS: Forty-six percent of the cohort developed mobility limitation. White and black men with a high BMI (>= 30 kg/m(2)), high total percentage body fat (>31.3%), or high waist circumference (>= 102 cm) had an approximately 60%, 40%, and 40%, respectively, higher risk of incident mobility limitation than those with low adiposity. In women, high adiposity was also associated with a significantly higher mobility limitation risk than in those with low adiposity. Low physical activity (lowest quartile) was associated with a 70% higher risk of mobility limitation in all groups. Persons with high adiposity and low physical activity were at particularly high risk of mobility limitation. People with high adiposity who were physically active had an equally high risk of mobility limitation as inactive people with low adiposity. CONCLUSION: High adiposity and low self-reported physical activity predicted the onset of mobility limitation in well-functioning older persons. Preventing weight gain in old age and promoting physical activity in obese and non-obese older persons may therefore be effective strategies to prevent mobility loss and future disability. C1 [Koster, Annemarie; Patel, Kushang V.; Harris, Tamara B.] NIA, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA. [Koster, Annemarie; Van Eijk, Jacques Th. M.] Univ Maastricht, Dept Hlth Care Studies, Maastricht, Netherlands. [Visser, Marjolein] Vrije Univ Amsterdam, Fac Earth & Life Sci, Inst Hlth Sci, Amsterdam, Netherlands. [Kanaya, Alka M.] Univ Calif San Francisco, Div Gen Internal Med, San Francisco, CA 94143 USA. [De Rekeneire, Nathalie] Ctr Dis Control & Prevent, Diabetes Translat Div, Atlanta, GA USA. [Newman, Anne B.] Univ Pittsburgh, Dept Epidemiol, Grad Sch Publ Hlth, Pittsburgh, PA USA. [Tylavsky, Frances A.] Univ Tennessee, Dept Prevent Med, Memphis, TN USA. [Kritchevsky, Stephen B.] Wake Forest Univ, Sticht Ctr Aging, Sect Gerontol & Geriat Med, Sch Med, Winston Salem, NC USA. RP Koster, A (reprint author), NIA, Lab Epidemiol Demog & Biometry, 7201 Wisconsin Ave Gateway Bldg,Suite 3C309, Bethesda, MD 20892 USA. EM kostera@mail.nih.gov RI Koster, Annemarie/E-7438-2010; Newman, Anne/C-6408-2013; OI Newman, Anne/0000-0002-0106-1150; Kritchevsky, Stephen/0000-0003-3336-6781 FU Intramural NIH HHS; NIA NIH HHS [N01-AG-6-2101, N01-AG-6-2103, N01-AG-6-2106] NR 38 TC 47 Z9 47 U1 10 U2 16 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-8614 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2008 VL 56 IS 4 BP 636 EP 643 DI 10.1111/j.1532-5415.2007.01632.x PG 8 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA 282IX UT WOS:000254562200007 PM 18284534 ER PT J AU Chen, HL Guo, XG AF Chen, Honglei Guo, Xuguang TI Obesity and functional disability in elderly Americans SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Article DE functional disability; obesity; waist circumference; body mass index ID BODY-MASS INDEX; EXAMINATION SURVEY NHANES; LATE-LIFE DISABILITY; PHYSICAL-DISABILITY; WAIST CIRCUMFERENCE; NATIONAL-HEALTH; OLDER PERSONS; WEIGHT CHANGE; US ADULTS; WOMEN AB OBJECTIVES: To investigate whether indicators of obesity are associated with functional disabilities in elderly American women and men. DESIGN: Cross-sectional. SETTING: National Health and Nutrition Examination Survey (NHANES) 1999 to 2004, United States. PARTICIPANTS: One thousand six hundred eighty-four elderly (aged >= 60) women and 1,611 elderly men. MEASUREMENTS: Functional disabilities. RESULTS: In women, body mass index (BMI) and waist circumference were each related to higher prevalence of all measures of disabilities. Compared with the lowest quartile of waist circumference, the multivariate odds ratios (ORs) of the highest quartile for having difficulties in functional domains were 2.4 (95% confidence interval (CI)=1.6-3.6) for activities of daily living, 2.3 (95% CI=1.6-3.3) for instrumental activities of daily living, 2.6 (95% CI=1.6-4.1) for leisure and social activities, 4.8 (95% CI=3.4-6.9) for lower extremity mobility, and 2.9 (95% CI=2.1-4.0) for general physical activity. In men, these associations were moderate; the corresponding ORs were 1.2 (95% CI=0.8-2.0), 1.3 (95% CI=0.9-2.1), 2.1 (95% CI=1.2-3.7), 1.8 (95% CI=1.2-2.7), and 2.1 (95% CI=1.5-2.8), respectively. Similar results were obtained for BMI. These associations could not be explained by the presence of major chronic conditions. When adjusted simultaneously, waist circumference appeared to be a better predictor than BMI of disability in women. CONCLUSION: The results suggest that indicators of obesity are related to functional disabilities in elderly Americans. C1 [Chen, Honglei] Natl Inst Environm Hlth Sci, Epidemiol Branch, Res Triangle Pk, NC 27709 USA. [Guo, Xuguang] Ctr Hlth Res, Stat Sci & Epidemiol Res Div, Durham, NC USA. RP Chen, HL (reprint author), Natl Inst Environm Hlth Sci, Epidemiol Branch, 111 T W Alexander Dr,POB 12233 Mail Drop-A3-05, Res Triangle Pk, NC 27709 USA. EM chenh2@niehs.nih.gov OI Chen, Honglei/0000-0003-3446-7779 FU Intramural NIH HHS [Z01 ES101986-02]; NIEHS NIH HHS [N01ES55547] NR 25 TC 73 Z9 75 U1 1 U2 5 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-8614 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2008 VL 56 IS 4 BP 689 EP 694 DI 10.1111/j.1532-5415.2007.01624.x PG 6 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA 282IX UT WOS:000254562200014 PM 18266843 ER PT J AU McDermott, MM Tian, L Ferrucci, L Liu, K Guralnik, JM Liao, Y Pearce, WH Criqui, MH AF McDermott, Mary M. Tian, Lu Ferrucci, Luigi Liu, Kiang Guralnik, Jack M. Liao, Yihua Pearce, William H. Criqui, Michael H. TI Associations between lower extremity ischemia, upper and lower extremity strength, and functional impairment with peripheral arterial disease SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Article DE intermittent claudication; peripheral arterial disease; physical functioning; limb ischemia; limb strength ID ANKLE-BRACHIAL INDEX; SKELETAL-MUSCLE; INTERMITTENT CLAUDICATION; LEG SYMPTOMS; PERFORMANCE; CLASSIFICATION; OSTEOARTHRITIS; DISABILITY; CRITERIA; WALKING AB OBJECTIVES: To identify associations between lower extremity ischemia and leg strength, leg power, and hand grip in persons with and without lower extremity peripheral arterial disease (PAD). To determine whether poorer strength may mediate poorer lower extremity performance in persons with lower arterial brachial index (ABI) levels. DESIGN: Cross-sectional. SETTING: Academic medical centers. PARTICIPANTS: Four hundred twenty-four persons with PAD and 271 without PAD. MEASUREMENTS: Isometric knee extension and plantarflexion strength and handgrip strength were measured using a computer-linked strength chair. Knee extension power was measured using the Nottingham leg rig. ABI, 6-minute walk, and usual and fastest 4-m walking velocity were measured. Results were adjusted for potential confounders. RESULTS: Lower ABI values were associated with lower plantarflexion strength (P trend=.04) and lower knee extension power (P trend <.001). There were no significant associations between ABI and handgrip or knee extension isometric strength. Significant associations between ABI and measures of lower extremity performance were attenuated after additional adjustment for measures of strength. CONCLUSION: These results are consistent with the hypothesis that lower extremity ischemia impairs strength specifically in distal lower extremity muscles. Associations between lower extremity ischemia and impaired lower extremity strength may mediate associations between lower ABI values and greater functional impairment. C1 [McDermott, Mary M.] Lab Clin Epidemiol, Dept Med, Bethesda, MD USA. [McDermott, Mary M.; Tian, Lu; Liu, Kiang; Liao, Yihua] Lab Clin Epidemiol, Dept Prevent Med, Bethesda, MD USA. [Guralnik, Jack M.] NIA, Lab Epidemiol Degmog & Biometry, Bethesda, MD 20892 USA. [Pearce, William H.] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA. [Criqui, Michael H.] Univ Calif San Diego, Dept Family & Prevent Med, San Diego, CA 92103 USA. RP McDermott, MM (reprint author), 750 N Lake Shore Dr 10th Floor, Chicago, IL 60611 USA. EM mdm608@northwestern.edu FU Intramural NIH HHS [Z99 AG999999]; NCRR NIH HHS [M01 RR000048, RR-00048]; NHLBI NIH HHS [R01-HL073351, R01-HL58099, R01-HL64739, R01-HL71223, R01 HL064739, R01 HL071223, R01 HL073351, R01-HL076298, R01 HL076298] NR 27 TC 33 Z9 34 U1 1 U2 2 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-8614 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2008 VL 56 IS 4 BP 724 EP 729 DI 10.1111/j.1532-5415.2008.01633.x PG 6 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA 282IX UT WOS:000254562200020 PM 18284536 ER PT J AU Cawthon, PM Fox, KM Delmonico, MJ Chiou, CF Gandra, SR Anthony, MS Sewall, A Goodpaster, B Satterfield, S Cummings, SR Harris, T AF Cawthon, P. M. Fox, K. M. Delmonico, M. J. Chiou, C. F. Gandra, S. R. Anthony, M. S. Sewall, A. Goodpaster, B. Satterfield, S. Cummings, S. R. Harris, T. TI Muscle strength, physical function and risk of hospitalization in healthy older adults SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Meeting of the American-Geriatrics-Society CY APR 30-MAY 04, 2008 CL Washington, DC SP Amer Geriatr Soc C1 [Cawthon, P. M.; Cummings, S. R.] CPMC, San Francisco, CA USA. [Fox, K. M.] Strateg Healthcare Solut LLC, Monkton, MD USA. [Delmonico, M. J.; Goodpaster, B.] Univ Pittsburgh, Pittsburgh, PA USA. [Chiou, C. F.; Gandra, S. R.; Anthony, M. S.] The Amgen, Thousand Oaks, CA USA. [Sewall, A.] Sewall Inc, Bethesda, MD USA. [Satterfield, S.] Univ Tennessee, Memphis, TN USA. [Harris, T.] NIA, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-8614 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2008 VL 56 IS 4 SU S MA B67 BP S86 EP S87 PG 2 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA 286IT UT WOS:000254840300252 ER PT J AU Devonshire, AL Ling, SM Bos, A Metter, E Lauretani, F Simonsick, EM Ferrucci, L AF Devonshire, A. L. Ling, S. M. Bos, A. Metter, E. Lauretani, F. Simonsick, E. M. Ferrucci, L. TI Associations of leg muscle quality and motor nerve function with walking speed: data from the Baltimore Longitudinal Study of Aging (BLSA) SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Meeting of the American-Geriatrics-Society CY APR 30-MAY 04, 2008 CL Washington, DC SP Amer Geriatr Soc C1 [Devonshire, A. L.; Ling, S. M.; Bos, A.; Metter, E.; Simonsick, E. M.; Ferrucci, L.] NIA, Clin Res Branch, Baltimore, MD 21224 USA. [Lauretani, F.] Tuscany Reg Hlth Agcy, Florence, Italy. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-8614 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2008 VL 56 IS 4 SU S MA D10 BP S162 EP S162 PG 1 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA 286IT UT WOS:000254840300470 ER PT J AU Fujikami, G Masaki, K Chen, R Schatz, I Laurin, D Abbott, R Ross, G Petrovitch, H White, L Blanchette, P Laurier, L AF Fujikami, G. Masaki, K. Chen, R. Schatz, I. Laurin, D. Abbott, R. Ross, G. Petrovitch, H. White, L. Blanchette, P. Laurier, L. TI Clinical student research awardee association between low blood pressure and cognitive function in late life: The Honolulu-Asia aging study SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Meeting of the American-Geriatrics-Society CY APR 30-MAY 04, 2008 CL Washington, DC SP Amer Geriatr Soc C1 [Fujikami, G.; Masaki, K.; Schatz, I.; Abbott, R.; Ross, G.; Petrovitch, H.; White, L.; Blanchette, P.] Univ Hawaii, John A Burns Sch Med, Honolulu, HI 96822 USA. [Masaki, K.; Chen, R.; Abbott, R.; Petrovitch, H.; White, L.] Pacific Hlth Res Inst, Honolulu, HI USA. [Ross, G.] Dept Vet Affairs, Honolulu, HI USA. [Laurin, D.; Laurier, L.] NIA, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-8614 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2008 VL 56 IS 4 SU S MA P10 BP S4 EP S4 PG 1 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA 286IT UT WOS:000254840300011 ER PT J AU Hardy, SE Ferrucci, L Harris, T Satterfield, S Schwartz, A Simonsick, E Visser, M Newman, A AF Hardy, S. E. Ferrucci, L. Harris, T. Satterfield, S. Schwartz, A. Simonsick, E. Visser, M. Newman, A. TI Fatigue and decline in gait speed: Data from the health, aging and body composition study SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Meeting of the American-Geriatrics-Society CY APR 30-MAY 04, 2008 CL Washington, DC SP Amer Geriatr Soc C1 [Hardy, S. E.; Newman, A.] Univ Pittsburgh, Pittsburgh, PA USA. [Ferrucci, L.; Harris, T.; Simonsick, E.; Visser, M.] NIA, Bethesda, MD 20892 USA. [Satterfield, S.] Univ Tennessee, Memphis, TN USA. [Schwartz, A.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Visser, M.] Vrije Univ Amsterdam, Amsterdam, Netherlands. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-8614 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2008 VL 56 IS 4 SU S MA D48 BP S175 EP S175 PG 1 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA 286IT UT WOS:000254840300508 ER PT J AU Ju, YL Bos, A Simonsick, EM Scott, W Lincoln, A Hochberg, M Ling, SM AF Ju, Y. L. Bos, A. Simonsick, E. M. Scott, W. Lincoln, A. Hochberg, M. Ling, S. M. TI Are adults with a knee replacement more physically active than those with knee osteoarthritis and intact knees? SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Meeting of the American-Geriatrics-Society CY APR 30-MAY 04, 2008 CL Washington, DC SP Amer Geriatr Soc C1 [Ju, Y. L.; Bos, A.; Simonsick, E. M.; Ling, S. M.] NIA, Clin Res Branch, Baltimore, MD 21224 USA. [Ju, Y. L.; Lincoln, A.] Medstar Res Inst, Hyattsville, MD USA. [Scott, W.] Johns Hopkins Univ, Baltimore, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-8614 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2008 VL 56 IS 4 SU S MA A140 BP S64 EP S65 PG 2 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA 286IT UT WOS:000254840300185 ER PT J AU Kiel, DP Hannan, MT Barton, BA Lang, TF Bouxsein, ML Brown, K Shane, E Magaziner, J Zimmerman, S Harris, T Rubin, CT AF Kiel, D. P. Hannan, M. T. Barton, B. A. Lang, T. F. Bouxsein, M. L. Brown, K. Shane, E. Magaziner, J. Zimmerman, S. Harris, T. Rubin, C. T. TI The "VIBES" trial: Low magnitude mechanical stimulation (LMMS) to improve bone mineral density(BMD) SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Meeting of the American-Geriatrics-Society CY APR 30-MAY 04, 2008 CL Washington, DC SP Amer Geriatr Soc C1 [Kiel, D. P.; Hannan, M. T.] HSL, Inst Aging Res, Boston, MA USA. [Barton, B. A.; Brown, K.] Maryland Med Res Inst, Baltimore, MD USA. [Bouxsein, M. L.] BIDMIC, Ortho Biomech Lab, Boston, MA USA. [Lang, T. F.] UCSF, San Francisco, CA USA. [Rubin, C. T.] SUNY Stony Brook, Stony Brook, NY 11794 USA. [Magaziner, J.] Univ Texas MD Anderson Canc Ctr, Baltimore, MD USA. [Zimmerman, S.] UNC, Cecil G Sheps Ctr Hlth Serv Rsch, Chapel Hill, NC USA. [Harris, T.] Columbia Univ, Dept Med, New York, NY USA. [Harris, T.] NIA, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-8614 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2008 VL 56 IS 4 SU S MA C41 BP S125 EP S125 PG 1 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA 286IT UT WOS:000254840300364 ER PT J AU Manini, T Cesari, M Hardy, S Newman, A Bauer, D Ryder, K Harris, T Shorr, R AF Manini, T. Cesari, M. Hardy, S. Newman, A. Bauer, D. Ryder, K. Harris, T. Shorr, R. TI Recovering from mobility limitation: A common practice among older adults SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Meeting of the American-Geriatrics-Society CY APR 30-MAY 04, 2008 CL Washington, DC SP Amer Geriatr Soc C1 [Manini, T.; Cesari, M.; Shorr, R.] Univ Florida, Gainesville, FL USA. [Harris, T.] NIA, Bethesda, MD 20892 USA. [Hardy, S.; Newman, A.] Univ Pittsburgh, Pittsburgh, PA USA. [Ryder, K.] Univ Tennessee, Memphis, TN USA. [Bauer, D.] Univ Calif San Francisco, San Francisco, CA 94143 USA. RI Cesari, Matteo/A-4649-2008 OI Cesari, Matteo/0000-0002-0348-3664 NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-8614 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2008 VL 56 IS 4 SU S MA D52 BP S176 EP S177 PG 2 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA 286IT UT WOS:000254840300512 ER PT J AU Nesbitt, MJ Bos, A Padilha, DM Ling, SM Reynolds, MA AF Nesbitt, M. J. Bos, A. Padilha, D. M. Ling, S. M. Reynolds, M. A. TI Is tooth loss associated with lower hip bone mineral density? SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Meeting of the American-Geriatrics-Society CY APR 30-MAY 04, 2008 CL Washington, DC SP Amer Geriatr Soc C1 [Nesbitt, M. J.; Bos, A.; Ling, S. M.] NIA, Clin Res Branch, Baltimore, MD 21224 USA. [Reynolds, M. A.] Univ Maryland, Baltimore, MD 21201 USA. [Padilha, D. M.] Univ Fed Rio Grande do Sul, Porto Alegre, RS, Brazil. NR 0 TC 0 Z9 0 U1 0 U2 1 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-8614 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2008 VL 56 IS 4 SU S MA B42 BP S78 EP S78 PG 1 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA 286IT UT WOS:000254840300227 ER PT J AU Ruby, CM Boudreau, RM Roumani, YF Newman, AB Wright, R Shorr, R Baucr, D Simonsick, E Hilmer, S Resnick, N Hanlon, JT AF Ruby, C. M. Boudreau, R. M. Roumani, Y. F. Newman, A. B. Wright, R. Shorr, R. Baucr, D. Simonsick, E. Hilmer, S. Resnick, N. Hanlon, J. T. TI The impact of medication use on urinary incontinence in community dwelling elderly women SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Meeting of the American-Geriatrics-Society CY APR 30-MAY 04, 2008 CL Washington, DC SP Amer Geriatr Soc C1 [Ruby, C. M.] Univ Pittsburgh, Dept Pharm & Therapeut, Pittsburgh, PA USA. [Ruby, C. M.; Roumani, Y. F.; Newman, A. B.; Wright, R.; Resnick, N.; Hanlon, J. T.] Univ Pittsburgh, Dept Geriatr Med, Pittsburgh, PA USA. [Boudreau, R. M.; Newman, A. B.] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA USA. [Hanlon, J. T.] Vet Affairs Hlth Care Syst, GRECC, Pittsburgh, PA USA. [Hanlon, J. T.] Ctr Hlth Equ Res & Promot, Pittsburgh, PA USA. [Shorr, R.] Vet Affairs Hlth Care Syst, N Florida S Georgia VHS GRECC, Gainesville, FL USA. [Baucr, D.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Simonsick, E.] NIA, Bethesda, MD 20892 USA. [Hilmer, S.] Univ Sydney, Sydney, NSW 2006, Australia. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-8614 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2008 VL 56 IS 4 SU S MA P39 BP S15 EP S15 PG 1 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA 286IT UT WOS:000254840300040 ER PT J AU Sink, KM Lovato, J Williamson, J Atkinson, H Carlson, MC Lopez, O Nahin, R DeKosky, ST Goff, D AF Sink, K. M. Lovato, J. Williamson, J. Atkinson, H. Carlson, M. C. Lopez, O. Nahin, R. DeKosky, S. T. Goff, D. TI Anticholinergic burden is associated with worse physical function: The ginkgo evaluation of memory study (GEMS) SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Meeting of the American-Geriatrics-Society CY APR 30-MAY 04, 2008 CL Washington, DC SP Amer Geriatr Soc C1 [Sink, K. M.; Lovato, J.; Williamson, J.; Atkinson, H.; Goff, D.] Wake Forest Univ, Winston Salem, NC 27109 USA. [Carlson, M. C.] Johns Hopkins, Baltimore, MD USA. [Lopez, O.; DeKosky, S. T.] U Pittsburgh, Pittsburgh, PA USA. [Nahin, R.] NCCAM, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-8614 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2008 VL 56 IS 4 SU S MA P28 BP S11 EP S11 PG 1 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA 286IT UT WOS:000254840300029 ER PT J AU Tummala, M Kanapuru, B Prabhaker, M Patel, KV Patel, WB AF Tummala, M. Kanapuru, B. Prabhaker, M. Patel, K. V. Patel, W. B. TI Aging in India: Urban/rural divide SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Meeting of the American-Geriatrics-Society CY APR 30-MAY 04, 2008 CL Washington, DC SP Amer Geriatr Soc C1 [Tummala, M.; Kanapuru, B.; Prabhaker, M.; Patel, K. V.; Patel, W. B.] NIA, Clin Res Branch, Baltimore, MD 21224 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-8614 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2008 VL 56 IS 4 SU S MA B48 BP S80 EP S80 PG 1 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA 286IT UT WOS:000254840300233 ER PT J AU Whitt, KJ Roth, SM Bos, A Muller, D Ferrucci, L Ling, SM AF Whitt, K. J. Roth, S. M. Bos, A. Muller, D. Ferrucci, L. Ling, S. M. TI Associations between vitamin D receptor polymorphisms, serum vitamin D, and markers of calcium homeostasis in the Baltimore Longitudinal Study of Aging (BLSA) SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Meeting of the American-Geriatrics-Society CY APR 30-MAY 04, 2008 CL Washington, DC SP Amer Geriatr Soc C1 [Whitt, K. J.; Bos, A.; Muller, D.; Ferrucci, L.; Ling, S. M.] NIA, Intramural Res Program, NIH, Baltimore, MD 21224 USA. [Whitt, K. J.] George Mason Univ, Fairfax, VA 22030 USA. [Roth, S. M.] Univ Maryland, College Pk, MD 20742 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-8614 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2008 VL 56 IS 4 SU S MA A7 BP S20 EP S20 PG 1 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA 286IT UT WOS:000254840300053 ER PT J AU Singh, SR Hou, SX AF Singh, Shree Ram Hou, Steven X. TI Lessons learned about adult kidney stem cells from the malpighian tubules of Drosophila SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Review ID RENAL TUBULE; POSTISCHEMIC KIDNEY; EPITHELIAL-CELLS; PROGENITOR CELLS; SELF-RENEWAL; JAK-STAT; REPAIR; CAPACITY; NICHE; MESENCHYME AB All multicellular organisms have a specialized organ to concentrate and excrete wastes from the body. The kidneys in vertebrates and the malpighian tubules in Drosophila accomplish these functions. Mammals and Drosophila share some similar features during renal tubular development. Vertebrate kidneys are derived through the mutual induction of the ureteric bud and metanephric mesoderm, whereas the malpighian tubules of Drosophila develop from the hindgut primordium and visceral mesoderm. The vertebrate kidney also has the capacity to recover and regenerate following episodes of acute injury. Previous studies suggest that stem cells and progenitor cells may be involved in the repair and regeneration of injured renal tissue. However, studies differ as to the source of the regenerating renal cells. Recently, multipotent stem cells in Drosophila malpighian tubules were identified, and it was demonstrated that several differentiated cells in the malpighian tubules arise from these stem cells. In this article, the current understanding of kidney development and stem cell fate in mammal and Drosophila is compared. Furthermore, the potential application of the adult renal stem cells in kidney repair and the treatment of kidney cancers are discussed. C1 [Singh, Shree Ram; Hou, Steven X.] NCI, NIH, Mouse Canc Genet Program, Frederick, MD 21702 USA. RP Singh, SR (reprint author), NCI, NIH, Mouse Canc Genet Program, Frederick, MD 21702 USA. EM shou@mail.ncifcrf.gov RI Singh, Shree Ram/B-7614-2008 OI Singh, Shree Ram/0000-0001-6545-583X FU Intramural NIH HHS [Z99 CA999999] NR 50 TC 12 Z9 14 U1 0 U2 4 PU AMER SOC NEPHROLOGY PI WASHINGTON PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA SN 1046-6673 J9 J AM SOC NEPHROL JI J. Am. Soc. Nephrol. PD APR PY 2008 VL 19 IS 4 BP 660 EP 666 DI 10.1681/ASN-2007121307 PG 7 WC Urology & Nephrology SC Urology & Nephrology GA 283TJ UT WOS:000254659100006 PM 18287558 ER EF