FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU VAUPEL, DB
KIMES, AS
LONDON, ED
AF VAUPEL, DB
KIMES, AS
LONDON, ED
TI COMPARISON OF 7-NITROINDAZOLE WITH OTHER NITRIC-OXIDE SYNTHASE
INHIBITORS AS ATTENUATORS OF OPIOID WITHDRAWAL
SO PSYCHOPHARMACOLOGY
LA English
DT Article
DE NITRIC OXIDE SYNTHASE; MORPHINE; DEPENDENCE; OPIOID WITHDRAWAL;
7-NITROINDAZOLE; L-IMINOETHYL ORNITHINE; L-N-G-NITROARGININE; NITRIC
OXIDE; RATS; BLOOD PRESSURE
ID MEDIATED HYPERTENSIVE RESPONSE; RECEPTOR ANTAGONIST MK-801; NORMOTENSIVE
RATS; BLOOD-PRESSURE; DEPENDENT RATS; MORPHINE; BUPRENORPHINE;
CLONIDINE; ACTIVATION; NEURONS
AB Previously, we demonstrated that two nonselective inhibitors of nitric oxide synthase (NOS), L-N-G-nitroarginine (L-NNA) and L-N-G-nitroarginine methyl ester (L-NAME), reduced some signs of morphine withdrawal in rats. The present work extended these studies to include 7-nitroindazole (7-NI), an inhibitor specific for cerebral NOS, and N(5)-(1-iminoethyl)-L-ornithine (L-NIO), a potent inhibitor of endothelial NOS. Behavioral effects of these four NOS inhibitors and clonidine, an alpha(2)-adrenoceptor, agonist, on morphine withdrawal in rats were assessed. Rats received one 75-mg morphine pellet subcutaneously (SC). Three days later, NOS inhibitors were administered IP 1 h before withdrawal was precipitated with naloxone (0.5 mg/kg, SC) and scored. 7-NI, L-NIO, L-NAME and L-NNA produced dose-related decreases in weight loss, diarrhea, wet dog shakes and grooming. 7-NI also reduced mastication, salivation and genital effects. Clonidine produced effects similar to 7-NI. In awake, morphine-naive and morphine-dependent rats not subjected to withdrawal, 7-NI was the only NOS inhibitor that did not increase blood pressure. Because 7-NI attenuated more signs of opioid withdrawal than L-NNA, L-NAME or L-NIO without causing hypertension, 7-NI appears to warrant further testing as a potential candidate for human use.
C1 UNIV MARYLAND,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,BALTIMORE,MD 21201.
JOHNS HOPKINS MED INST,DEPT RADIOL,BALTIMORE,MD 21205.
RP VAUPEL, DB (reprint author), NIDA,INTRAMURAL RES PROGRAM,NEUROIMAGING & DRUG ACT SECT,BALTIMORE,MD 21224, USA.
NR 25
TC 60
Z9 62
U1 0
U2 1
PU SPRINGER VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010
SN 0033-3158
J9 PSYCHOPHARMACOLOGY
JI Psychopharmacology
PD APR
PY 1995
VL 118
IS 4
BP 361
EP 368
PG 8
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA QY586
UT WOS:A1995QY58600001
PM 7568621
ER
PT J
AU RESNICK, SM
COSTA, PT
AF RESNICK, SM
COSTA, PT
TI COMMENTS ON USE OF H-1 MR SPECTROSCOPY FOR DIAGNOSIS OF PROBABLE
ALZHEIMER-DISEASE
SO RADIOLOGY
LA English
DT Editorial Material
DE AGING; BRAIN, METABOLISM; DEMENTIA; EDITORIALS; MAGNETIC RESONANCE (MR),
SPECTROSCOPY
RP RESNICK, SM (reprint author), NIA,GERONTOL RES CTR,PERSONAL & COGNIT LAB,4940 EASTERN AVE,BALTIMORE,MD 21224, USA.
NR 9
TC 6
Z9 6
U1 0
U2 0
PU RADIOLOGICAL SOC NORTH AMER
PI EASTON
PA 20TH AND NORTHAMPTON STS, EASTON, PA 18042
SN 0033-8419
J9 RADIOLOGY
JI Radiology
PD APR
PY 1995
VL 195
IS 1
BP 14
EP 15
PG 2
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA QM663
UT WOS:A1995QM66300005
PM 7892455
ER
PT J
AU DAVIDSON, AJ
CHOYKE, PL
HARTMAN, DS
DAVIS, CJ
AF DAVIDSON, AJ
CHOYKE, PL
HARTMAN, DS
DAVIS, CJ
TI RENAL MEDULLARY CARCINOMA-ASSOCIATED WITH SICKLE-CELL TRAIT - RADIOLOGIC
FINDINGS
SO RADIOLOGY
LA English
DT Article
DE KIDNEY NEOPLASMS, DIAGNOSIS; SICKLE CELL TRAIT
ID COMPUTED-TOMOGRAPHY; ULTRASOUND; LYMPHOMA; KIDNEY
AB PURPOSE: To correlate the radiologic and pathologic findings in patients with renal medullary carcinoma and sickle cell trait.
MATERIALS AND METHODS: Radiologic studies of five pathologically proved cases of renal medullary carcinoma were retrospectively correlated with gross pathologic findings. Excretory urograms, computed tomographic (CT) scans, sonograms, photographs of the gross surgical specimens, and an angiogram were available for review. Each case was analyzed for tumor location, pattern of growth, contrast enhancement and echotexture, angiographic pattern, and stage.
RESULTS: All tumors arose centrally within the kidney, grew in an infiltrative pattern, and invaded the renal sinus. Caliectasis without pelviectasis was present in three cases. Contrast enhancement and echotexture were heterogeneous in all patients. Tumor necrosis with communication into the collecting system occurred in one patient. The one available angiogram demonstrated hypovascularity.
CONCLUSION: Patients with renal medullary carcinoma share particular demographic, clinical, and radiologic features that might enable radiologists to suggest a specific diagnosis.
C1 ARMED FORCES INST PATHOL,DEPT GENITOURINARY PATHOL,WASHINGTON,DC 20306.
NIH,CTR CLIN,DEPT RADIOL,BETHESDA,MD 20892.
PENN STATE UNIV,SCH MED,DEPT RADIOL,HERSHEY,PA.
RP DAVIDSON, AJ (reprint author), ARMED FORCES INST PATHOL,AMER REGISTRY PATHOL,DEPT RADIOL PATHOL,14TH & ALASKA AVE NW,WASHINGTON,DC 20306, USA.
NR 18
TC 59
Z9 61
U1 0
U2 1
PU RADIOLOGICAL SOC NORTH AMER
PI EASTON
PA 20TH AND NORTHAMPTON STS, EASTON, PA 18042
SN 0033-8419
J9 RADIOLOGY
JI Radiology
PD APR
PY 1995
VL 195
IS 1
BP 83
EP 85
PG 3
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA QM663
UT WOS:A1995QM66300016
PM 7892499
ER
PT J
AU COSMIDES, GJ
AF COSMIDES, GJ
TI ELECTRONIC SURVEILLANCE OF THE PHARMACOLOGY-TOXICOLOGY LITERATURE - THE
NEED FOR CONTROLLED VOCABULARIES AND REGISTRY SYSTEMS
SO REGULATORY TOXICOLOGY AND PHARMACOLOGY
LA English
DT Article
ID CLASSIFICATION
AB Controlled vocabularies of ''preferred names'' and registry systems are essential in electronic indexing, storing, searching, and retrieving the world's published literature. The most efficient and comprehensive search is accomplished by using the preferred name. Without a controlled vocabulary or a registry system, it would be necessary to remember every name that might have been used by authors since January 1966, in order to retrieve all the citations on a chemical from over 7.8 million citations currently in the National Library of Medicine's MEDLINE and its backfiles. The task of creating the list of subject descriptors that make possible the surveillance of published literature via electronic databases requires the participation of the scientific community in developing domain-specific nomenclature, drug classification, controlled vocabularies, and registry systems as well. The biological unions of the International Council of Scientific Unions and its Committee on Data for Science and Technology are major contributors to the establishment and dissemination of standards for biological terminology and nomenclature. The objectives of the IUPHAR Nomenclature Committee include the development of a rational framework for the nomenclature of receptor classes or families and a classification for therapeutic agents. This will help define rules for the characterization and classification of receptors that are stable and easy to comprehend. The International Union of Pharmacology publishes guidelines for the classification of drugs and the nomenclature of receptors and ion channels. (C) 1995 Academic Press, Inc.
RP COSMIDES, GJ (reprint author), NATL LIB MED,BETHESDA,MD 20894, USA.
RI Henrich, Joseph/A-2403-2009
NR 11
TC 1
Z9 1
U1 0
U2 0
PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
PI SAN DIEGO
PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495
SN 0273-2300
J9 REGUL TOXICOL PHARM
JI Regul. Toxicol. Pharmacol.
PD APR
PY 1995
VL 21
IS 2
BP 208
EP 210
DI 10.1006/rtph.1995.1029
PG 3
WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology
SC Legal Medicine; Pharmacology & Pharmacy; Toxicology
GA QY863
UT WOS:A1995QY86300002
PM 7644707
ER
PT J
AU BOORMAN, GA
SEELY, JC
AF BOORMAN, GA
SEELY, JC
TI THE LACK OF AN OVARIAN EFFECT OF LIFETIME TALC EXPOSURE IN F344/N RATS
AND B6C3F1 MICE
SO REGULATORY TOXICOLOGY AND PHARMACOLOGY
LA English
DT Article; Proceedings Paper
CT International-Society-of-Regulatory-Toxicology-and-Pharmacology/US-FDA
Workshop on Talc - Consumer Uses and Health Perspectives
CY JAN 31-FEB 01, 1994
CL NIH, BETHESDA, MD
SP NIH
HO NIH
C1 NIEHS,PATHCO INC,RES TRIANGLE PK,NC 27709.
RP BOORMAN, GA (reprint author), NIEHS,ENVIRONM TOXICOL PROGRAM,PATHOL BRANCH,RES TRIANGLE PK,NC 27709, USA.
NR 5
TC 6
Z9 6
U1 0
U2 0
PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
PI SAN DIEGO
PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495
SN 0273-2300
J9 REGUL TOXICOL PHARM
JI Regul. Toxicol. Pharmacol.
PD APR
PY 1995
VL 21
IS 2
BP 242
EP 243
DI 10.1006/rtph.1995.1035
PG 2
WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology
SC Legal Medicine; Pharmacology & Pharmacy; Toxicology
GA QY863
UT WOS:A1995QY86300008
PM 7644712
ER
PT J
AU HARLOW, BL
HARTGE, PA
AF HARLOW, BL
HARTGE, PA
TI A REVIEW OF PERINEAL TALC EXPOSURE AND RISK OF OVARIAN-CANCER
SO REGULATORY TOXICOLOGY AND PHARMACOLOGY
LA English
DT Article; Proceedings Paper
CT International-Society-of-Regulatory-Toxicology-and-Pharmacology/US-FDA
Workshop on Talc - Consumer Uses and Health Perspectives
CY JAN 31-FEB 01, 1994
CL NIH, BETHESDA, MD
SP NIH
HO NIH
ID FOLLOW-UP; MORTALITY; WORKERS; TUMORS; WOMEN
AB The authors provide a detailed review of the events that led to the interest in talc as a possible ovarian carcinogen, the epidemiological studies published to date, and their perspective on the interpretation of the findings including potential limitations, biases, and issues surrounding the plausibility of a causal association. The authors conclude that the range of relative risk estimates from epidemiology, 1.0 to 1.8, is plausible, but that additional epidemiologic studies, especially prospective investigations are needed, In addition, clinicopathological studies are needed to confirm or deny the reports of talc embedded in human ovarian tissue and reports of talc migration through the human female reproductive tract. (C) 1995 Academic Press, Inc.
C1 NCI,DIV CANC ETIOL,BETHESDA,MD 20205.
RP HARLOW, BL (reprint author), HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,CTR OBSTET & GYNECOL EPIDEMIOL,BOSTON,MA 02115, USA.
NR 35
TC 26
Z9 26
U1 2
U2 3
PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
PI SAN DIEGO
PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495
SN 0273-2300
J9 REGUL TOXICOL PHARM
JI Regul. Toxicol. Pharmacol.
PD APR
PY 1995
VL 21
IS 2
BP 254
EP 260
DI 10.1006/rtph.1995.1039
PG 7
WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology
SC Legal Medicine; Pharmacology & Pharmacy; Toxicology
GA QY863
UT WOS:A1995QY86300012
PM 7644715
ER
PT J
AU BENFIELD, TL
VANSTEENWIJK, R
NIELSEN, TL
DICHTER, JR
LIPSCHIK, GY
JENSEN, BN
JUNGE, J
SHELHAMER, JH
LUNDGREN, JD
AF BENFIELD, TL
VANSTEENWIJK, R
NIELSEN, TL
DICHTER, JR
LIPSCHIK, GY
JENSEN, BN
JUNGE, J
SHELHAMER, JH
LUNDGREN, JD
TI INTERLEUKIN-8 AND EICOSANOID PRODUCTION IN THE LUNG DURING MODERATE TO
SEVERE PNEUMOCYSTIS-CARINII PNEUMONIA IN AIDS - A ROLE OF INTERLEUKIN-8
IN THE PATHOGENESIS OF PNEUMOCYSTIS-CARINII PNEUMONIA
SO RESPIRATORY MEDICINE
LA English
DT Article
ID ACQUIRED-IMMUNODEFICIENCY-SYNDROME; CONTROLLED TRIAL; VIRUS INFECTION;
CELL-LINE; CORTICOSTEROIDS; CYTOKINE; THERAPY
AB Pneumocystis carinii pneumonia (PCP) may cause severe respiratory distress. This is believed to be partly caused by the accumulation of neutrophils in the lung. Interleukin-8 (IL-8) and leukotriene B-4 (LTB(4)) are potent neutrophil chemo-attractants and activators. Eicosanoids [i.e. prostaglandins (PG) and leukotrienes (LT)] are pro-inflammatory mediators released from arachidonic acid by action of phospholipase A(2) (PLA(2)) and have been implicated in the host response to micro-organisms, Bronchoalveolar lavage (BAL) was performed on patients with PCP as part of a randomized study of adjuvant corticosteroids vs. placebo, in addition to standard antimicrobial therapy. Re-bronchoscopy was offered at day 10. BAL fluid was available for 26 patients who had follow-up bronchoscopy performed. At diagnosis, IL-8 levels were elevated in patients with PCP, compared to healthy controls, and correlated with relative BAL neutrophilia and P(A-a)O-2. LTB(4) was also elevated in PCP, but failed to correlate with either BAL neutrophilia or P(A-a)O-2. PLA, activity in patients correlated with IL-8 levels and BAL neutrophilia, but not with P(A-a)O-2. A trend towards a decrease in IL-8 levels in BAL fluid was detected in the corticosteroid-treated patients from days 0-10, whereas no change was detected in the placebo group. No change in levels of LTB(4), LTC(4), PGE(2), PGF(2 alpha), and PLA(2) were detected over time in either treatment group. This study establishes a correlation between IL-8, BAL neutrophilia and P(A-a)O-2, and suggests a role of IL-8 as a mediator in the pathogenesis of PCP, whereas the role of eicosanoids seems less clear.
C1 UNIV COPENHAGEN,HVIDOVRE HOSP,DEPT PATHOL,DK-2650 HVIDOVRE,DENMARK.
UNIV COPENHAGEN,RIGSHOSP,DEPT INFECT DIS,DK-2650 HVIDOVRE,DENMARK.
UNIV AMSTERDAM,ACAD MED CTR,DEPT PULMONOL,1105 AZ AMSTERDAM,NETHERLANDS.
NIH,WARREN G MAGNUSON CLIN CTR,DEPT CRIT CARE MED,BETHESDA,MD 20892.
RP BENFIELD, TL (reprint author), UNIV COPENHAGEN,HVIDOVRE HOSP,DEPT INFECT DIS 144,DK-2650 HVIDOVRE,DENMARK.
NR 27
TC 26
Z9 29
U1 0
U2 0
PU W B SAUNDERS CO LTD
PI LONDON
PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX
SN 0954-6111
J9 RESP MED
JI Respir. Med.
PD APR
PY 1995
VL 89
IS 4
BP 285
EP 290
DI 10.1016/0954-6111(95)90089-6
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System
SC Cardiovascular System & Cardiology; Respiratory System
GA QU714
UT WOS:A1995QU71400006
PM 7597268
ER
PT J
AU ROBERTS, B
SCHOOLER, C
HOMMER, D
COHEN, R
AF ROBERTS, B
SCHOOLER, C
HOMMER, D
COHEN, R
TI CONFIRMATORY FACTOR-ANALYSIS OF THE NEUROLOGICAL EVALUATION SCALE
SO SCHIZOPHRENIA RESEARCH
LA English
DT Meeting Abstract
C1 NIMH,SOCIOENVIRONM STUDIES LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD APR
PY 1995
VL 15
IS 1-2
BP 20
EP 20
DI 10.1016/0920-9964(95)95074-J
PG 1
WC Psychiatry
SC Psychiatry
GA QN952
UT WOS:A1995QN95200053
ER
PT J
AU GEJMAN, PV
GELERNTER, J
CRAVCHIK, A
GERSHON, ES
PICKAR, D
AF GEJMAN, PV
GELERNTER, J
CRAVCHIK, A
GERSHON, ES
PICKAR, D
TI TESTING PATHOPHYSIOLOGIC HYPOTHESES OF PSYCHIATRIC-ILLNESS BY
MOLECULAR-GENETIC APPROACHES
SO SCHIZOPHRENIA RESEARCH
LA English
DT Meeting Abstract
C1 NIMH,CNG,MOLEC CLIN INVEST UNIT,BETHESDA,MD 20892.
NR 1
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD APR
PY 1995
VL 15
IS 1-2
BP 39
EP 39
DI 10.1016/0920-9964(95)95126-T
PG 1
WC Psychiatry
SC Psychiatry
GA QN952
UT WOS:A1995QN95200101
ER
PT J
AU INGRAHAM, LJ
AF INGRAHAM, LJ
TI PREVALENCE OF DSM-IV CRITERIA FOR SCHIZOTYPAL PERSONALITY-DISORDER AMONG
THE BIOLOGICAL RELATIVES OF ADOPTEES WITH CHRONIC-SCHIZOPHRENIA
SO SCHIZOPHRENIA RESEARCH
LA English
DT Meeting Abstract
C1 NIMH,PSYCHOL & PSYCHOPATHOL LAB,INTRAMURAL RES PROGRAM,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD APR
PY 1995
VL 15
IS 1-2
BP 41
EP 41
DI 10.1016/0920-9964(95)95133-T
PG 1
WC Psychiatry
SC Psychiatry
GA QN952
UT WOS:A1995QN95200109
ER
PT J
AU HITRI, A
WYATT, RJ
AF HITRI, A
WYATT, RJ
TI DECREASED DOPAMINE TRANSPORTER RECEPTORS IN THE ANTERIOR CINGULATE
CORTEX OF SCHIZOPHRENIC-PATIENTS
SO SCHIZOPHRENIA RESEARCH
LA English
DT Meeting Abstract
C1 DEPT VET AFFAIRS MED CTR,WASHINGTON,DC 20422.
GEORGETOWN UNIV,SCH MED,WASHINGTON,DC 20422.
NIMH,NEUROPSYCHIAT BRANCH,WASHINGTON,DC 20422.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD APR
PY 1995
VL 15
IS 1-2
BP 59
EP 60
DI 10.1016/0920-9964(95)95188-F
PG 2
WC Psychiatry
SC Psychiatry
GA QN952
UT WOS:A1995QN95200164
ER
PT J
AU LIPSKA, BK
LILLRANK, SM
WEINBERGER, DR
AF LIPSKA, BK
LILLRANK, SM
WEINBERGER, DR
TI DISRUPTION OF CORTICAL AND SUBCORTICAL FUNCTION FOLLOWING DEVELOPMENTAL
HIPPOCAMPAL DAMAGE - A RAT MODEL OF SCHIZOPHRENIA
SO SCHIZOPHRENIA RESEARCH
LA English
DT Meeting Abstract
C1 NIMH,INTRAMURAL RES PROGRAM,CLIN BRAIN DISORDERS BRANCH,WASHINGTON,DC 20032.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD APR
PY 1995
VL 15
IS 1-2
BP 65
EP 65
DI 10.1016/0920-9964(95)95204-M
PG 1
WC Psychiatry
SC Psychiatry
GA QN952
UT WOS:A1995QN95200180
ER
PT J
AU NATSUKARI, N
WYATT, RJ
BAKER, I
TORREY, EF
KULAGA, H
MASSERANO, JM
AF NATSUKARI, N
WYATT, RJ
BAKER, I
TORREY, EF
KULAGA, H
MASSERANO, JM
TI ALTERED CYCLIC-AMP RESPONSE TO FORSKOLIN AND CHOLERA-TOXIN AFTER
PROTEIN-KINASE-C ACTIVATION IN EBV-TRANSFORMED B-LYMPHOCYTES FROM
SCHIZOPHRENICS
SO SCHIZOPHRENIA RESEARCH
LA English
DT Meeting Abstract
C1 NIMH,ST ELIZABETHS HOSP,CTR NEUROSCI,NEUROPSYCHIAT BRANCH,WASHINGTON,DC 20032.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD APR
PY 1995
VL 15
IS 1-2
BP 67
EP 67
DI 10.1016/0920-9964(95)95212-R
PG 1
WC Psychiatry
SC Psychiatry
GA QN952
UT WOS:A1995QN95200186
ER
PT J
AU BREIER, A
CARSON, R
ECKELMAN, W
DEBARTOLOMEIS, A
SAUNDERS, RC
WEINBERGER, D
SU, TP
PICKAR, D
AF BREIER, A
CARSON, R
ECKELMAN, W
DEBARTOLOMEIS, A
SAUNDERS, RC
WEINBERGER, D
SU, TP
PICKAR, D
TI IN-VIVO ESTIMATES OF SYNAPTIC DOPAMINE CONCENTRATIONS WITH C-11
RACLOPRIDE/PET - A DIRECT TEST OF THE DOPAMINE HYPOTHESIS
SO SCHIZOPHRENIA RESEARCH
LA English
DT Meeting Abstract
C1 NIMH,EXPTL THERAPEUT BRANCH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD APR
PY 1995
VL 15
IS 1-2
BP 76
EP 77
DI 10.1016/0920-9964(95)95240-A
PG 2
WC Psychiatry
SC Psychiatry
GA QN952
UT WOS:A1995QN95200216
ER
PT J
AU BREIER, A
MALHOTRA, A
PINALS, D
CHUNG, IW
HIDARY, J
SU, TP
HSIAO, J
PICKAR, D
AF BREIER, A
MALHOTRA, A
PINALS, D
CHUNG, IW
HIDARY, J
SU, TP
HSIAO, J
PICKAR, D
TI NEUROANATOMICAL LOCALIZATION OF NMDA RECEPTOR-MEDIATED PSYCHOSIS IN
HEALTHY CONTROLS AND SCHIZOPHRENIC-PATIENTS
SO SCHIZOPHRENIA RESEARCH
LA English
DT Meeting Abstract
C1 NIMH,EXPTL THERAPEUT BRANCH,BETHESDA,MD 20892.
NR 0
TC 2
Z9 2
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD APR
PY 1995
VL 15
IS 1-2
BP 77
EP 77
DI 10.1016/0920-9964(95)95242-2
PG 1
WC Psychiatry
SC Psychiatry
GA QN952
UT WOS:A1995QN95200217
ER
PT J
AU ELKASHEF, AM
DOUDET, D
COHEN, RM
WYATT, RJ
AF ELKASHEF, AM
DOUDET, D
COHEN, RM
WYATT, RJ
TI PRESYNAPTIC DOPAMINE FUNCTION IN SCHIZOPHRENIA - AN F-18 DOPA PET STUDY
SO SCHIZOPHRENIA RESEARCH
LA English
DT Meeting Abstract
C1 NIMH,NEUROPSYCHIAT BRANCH,WASHINGTON,DC 20032.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD APR
PY 1995
VL 15
IS 1-2
BP 82
EP 82
DI 10.1016/0920-9964(95)95257-A
PG 1
WC Psychiatry
SC Psychiatry
GA QN952
UT WOS:A1995QN95200231
ER
PT J
AU HSIAO, JK
CHUNG, IW
COHEN, R
PICKAR, D
AF HSIAO, JK
CHUNG, IW
COHEN, R
PICKAR, D
TI REGIONALLY SPECIFIC CHANGES IN BRAIN GLUCOSE-METABOLISM ASSOCIATION WITH
RESPONSE TO CLOZAPINE TREATMENT
SO SCHIZOPHRENIA RESEARCH
LA English
DT Meeting Abstract
C1 NIMH,EXPTL THERAPEUT BRANCH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD APR
PY 1995
VL 15
IS 1-2
BP 85
EP 86
DI 10.1016/0920-9964(95)95266-C
PG 2
WC Psychiatry
SC Psychiatry
GA QN952
UT WOS:A1995QN95200242
ER
PT J
AU KNABLE, MB
GONZALEZ, J
COPPOLA, R
JONES, DW
NAWROZ, S
GOREY, J
WEINBERGER, DR
AF KNABLE, MB
GONZALEZ, J
COPPOLA, R
JONES, DW
NAWROZ, S
GOREY, J
WEINBERGER, DR
TI I-123 IBZM SPECT IN NEUROLEPTIC-FREE SCHIZOPHRENIC-PATIENTS
SO SCHIZOPHRENIA RESEARCH
LA English
DT Meeting Abstract
C1 NIMH,CLIN BRAIN DISORDERS BRANCH,WASHINGTON,DC 20032.
NR 0
TC 2
Z9 2
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD APR
PY 1995
VL 15
IS 1-2
BP 88
EP 88
DI 10.1016/0920-9964(95)95274-D
PG 1
WC Psychiatry
SC Psychiatry
GA QN952
UT WOS:A1995QN95200250
ER
PT J
AU NOGA, JT
BARTLEY, AB
JONES, DW
TORREY, EF
WEINBERGER, DR
AF NOGA, JT
BARTLEY, AB
JONES, DW
TORREY, EF
WEINBERGER, DR
TI CORTICAL GYRAL ANATOMY AND GROSS BRAIN DIMENSIONS IN MONOZYGOTIC TWINS
DISCORDANT FOR SCHIZOPHRENIA EXAMINED WITH 3-D MRI
SO SCHIZOPHRENIA RESEARCH
LA English
DT Meeting Abstract
C1 ST ELIZABETH HOSP,NIMH,CTR NEUROSCI,DIRP,CLIN BRAIN DISORDERS BRANCH,WASHINGTON,DC 20032.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD APR
PY 1995
VL 15
IS 1-2
BP 93
EP 93
DI 10.1016/0920-9964(95)95289-L
PG 1
WC Psychiatry
SC Psychiatry
GA QN952
UT WOS:A1995QN95200266
ER
PT J
AU PICKAR, D
SU, TP
COPPOLA, R
LEE, CS
HSIAO, JK
BREIER, A
WEINBERGER, DR
AF PICKAR, D
SU, TP
COPPOLA, R
LEE, CS
HSIAO, JK
BREIER, A
WEINBERGER, DR
TI DA OCCUPANCY AND DOPAMINE RELEASE DETERMINED BY I-123 IBZM SPECT
FOLLOWING CLOZAPINE DOSE REDUCTION
SO SCHIZOPHRENIA RESEARCH
LA English
DT Meeting Abstract
C1 NIMH,EXPTL THERAPEUT BRANCH,BETHESDA,MD 20892.
NR 0
TC 3
Z9 3
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD APR
PY 1995
VL 15
IS 1-2
BP 96
EP 96
DI 10.1016/0920-9964(95)95298-N
PG 1
WC Psychiatry
SC Psychiatry
GA QN952
UT WOS:A1995QN95200274
ER
PT J
AU KOTRLA, KJ
MATTAY, VS
NAWROZ, S
SEXTON, RH
SANTHA, AKS
VANGELDEREN, P
DUYN, JH
MOONEN, CTW
FRANK, JA
WEINBERGER, DR
AF KOTRLA, KJ
MATTAY, VS
NAWROZ, S
SEXTON, RH
SANTHA, AKS
VANGELDEREN, P
DUYN, JH
MOONEN, CTW
FRANK, JA
WEINBERGER, DR
TI FUNCTIONAL MAGNETIC-RESONANCE-IMAGING IN NORMAL CONTROLS AND
SCHIZOPHRENICS
SO SCHIZOPHRENIA RESEARCH
LA English
DT Meeting Abstract
C1 NIMH,CLIN BRAIN DISORDERS BRANCH,WASHINGTON,DC 20032.
RI Duyn, Jozef/F-2483-2010; Moonen, Chrit/K-4434-2016
OI Moonen, Chrit/0000-0001-5593-3121
NR 0
TC 1
Z9 1
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD APR
PY 1995
VL 15
IS 1-2
BP 103
EP 103
DI 10.1016/0920-9964(95)95321-Y
PG 1
WC Psychiatry
SC Psychiatry
GA QN952
UT WOS:A1995QN95200296
ER
PT J
AU GOLD, J
CARPENTER, C
RANDOLPH, C
GOLDBERG, T
WEINBERGER, D
AF GOLD, J
CARPENTER, C
RANDOLPH, C
GOLDBERG, T
WEINBERGER, D
TI AUDITORY WORKING-MEMORY AND THE WISCONSIN CARD SORTING TEST
SO SCHIZOPHRENIA RESEARCH
LA English
DT Meeting Abstract
C1 NIMH,NEUROSCI CTR ST ELIZABETHS,WASHINGTON,DC 20032.
NR 0
TC 1
Z9 1
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD APR
PY 1995
VL 15
IS 1-2
BP 117
EP 118
DI 10.1016/0920-9964(95)95361-C
PG 2
WC Psychiatry
SC Psychiatry
GA QN952
UT WOS:A1995QN95200337
ER
PT J
AU GOLDBERG, TE
GOLD, JM
TORREY, EF
WEINBERGER, DR
AF GOLDBERG, TE
GOLD, JM
TORREY, EF
WEINBERGER, DR
TI SEX-DIFFERENCES AND NEUROCOGNITION IN SCHIZOPHRENIA
SO SCHIZOPHRENIA RESEARCH
LA English
DT Meeting Abstract
C1 NIMH,NEUROSCI CTR ST ELIZABETHS,CLIN BRAIN DISORDERS BRANCH,WASHINGTON,DC 20032.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD APR
PY 1995
VL 15
IS 1-2
BP 118
EP 118
DI 10.1016/0920-9964(95)95363-E
PG 1
WC Psychiatry
SC Psychiatry
GA QN952
UT WOS:A1995QN95200338
ER
PT J
AU SCHOOLER, C
ROBERTS, B
COHEN, R
AF SCHOOLER, C
ROBERTS, B
COHEN, R
TI OCULAR, COGNITIVE AND SOCIAL INTERFERENCE IN SCHIZOPHRENIA
SO SCHIZOPHRENIA RESEARCH
LA English
DT Meeting Abstract
C1 NIMH,SOCIOENVIRONM STUDIES LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD APR
PY 1995
VL 15
IS 1-2
BP 133
EP 133
DI 10.1016/0920-9964(95)95412-3
PG 1
WC Psychiatry
SC Psychiatry
GA QN952
UT WOS:A1995QN95200389
ER
PT J
AU BREIER, A
AF BREIER, A
TI NEGATIVE SYMPTOMS AND NORADRENERGIC FUNCTION
SO SCHIZOPHRENIA RESEARCH
LA English
DT Meeting Abstract
C1 NIMH,EXPTL THERAPEUT BRANCH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD APR
PY 1995
VL 15
IS 1-2
BP 143
EP 144
DI 10.1016/0920-9964(95)95445-F
PG 2
WC Psychiatry
SC Psychiatry
GA QN952
UT WOS:A1995QN95200421
ER
PT J
AU MALHOTRA, AK
WEINGARTNER, H
SIROCCO, K
PINALS, D
MISSAR, CD
PICKAR, D
BREJER, A
AF MALHOTRA, AK
WEINGARTNER, H
SIROCCO, K
PINALS, D
MISSAR, CD
PICKAR, D
BREJER, A
TI THE COGNITIVE EFFECTS OF KETAMINE, AN NMDA ANTAGONIST, IN NORMAL
CONTROLS AND DRUG-FREE SCHIZOPHRENIC-PATIENTS
SO SCHIZOPHRENIA RESEARCH
LA English
DT Meeting Abstract
C1 NIMH,EXPTL THERAPEUT BRANCH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD APR
PY 1995
VL 15
IS 1-2
BP 158
EP 158
DI 10.1016/0920-9964(95)95491-Q
PG 1
WC Psychiatry
SC Psychiatry
GA QN952
UT WOS:A1995QN95200467
ER
PT J
AU NOGA, JT
RODEFFER, CJ
WEINBERGER, DR
KLEINMAN, JE
AF NOGA, JT
RODEFFER, CJ
WEINBERGER, DR
KLEINMAN, JE
TI COMPARISON OF POLYDIPSIC BEHAVIOR IN SCHIZOPHRENIA-PATIENTS ON CLOZAPINE
VERSUS HALOPERIDOL
SO SCHIZOPHRENIA RESEARCH
LA English
DT Meeting Abstract
C1 ST ELIZABETH HOSP,NIMH,CTR NEUROSCI,DIRP,CLIN BRAIN DISORDERS BRANCH,WASHINGTON,DC 20032.
NR 0
TC 2
Z9 2
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD APR
PY 1995
VL 15
IS 1-2
BP 160
EP 160
DI 10.1016/0920-9964(95)95496-V
PG 1
WC Psychiatry
SC Psychiatry
GA QN952
UT WOS:A1995QN95200472
ER
PT J
AU PICKAR, D
AF PICKAR, D
TI MECHANISM OF ACTION OF CLOZAPINE - IMPLICATIONS FOR A NEW-GENERATION OF
ANTIPSYCHOTICS
SO SCHIZOPHRENIA RESEARCH
LA English
DT Meeting Abstract
C1 NIMH,EXPTL THERAPEUT BRANCH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD APR
PY 1995
VL 15
IS 1-2
BP 161
EP 161
DI 10.1016/0920-9964(95)95499-Y
PG 1
WC Psychiatry
SC Psychiatry
GA QN952
UT WOS:A1995QN95200476
ER
PT J
AU PINALS, DA
MALHOTRA, AK
MISSAR, CD
BREIER, A
PICKAR, D
AF PINALS, DA
MALHOTRA, AK
MISSAR, CD
BREIER, A
PICKAR, D
TI THE ROLE OF GENDER IN THE PHARMACOTHERAPY OF SCHIZOPHRENIA
SO SCHIZOPHRENIA RESEARCH
LA English
DT Meeting Abstract
C1 NIMH,EXPTL THERAPEUT BRANCH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD APR
PY 1995
VL 15
IS 1-2
BP 161
EP 161
DI 10.1016/0920-9964(95)95501-Y
PG 1
WC Psychiatry
SC Psychiatry
GA QN952
UT WOS:A1995QN95200477
ER
PT J
AU SU, TP
TUSKAN, J
TSAO, L
PICKAR, D
AF SU, TP
TUSKAN, J
TSAO, L
PICKAR, D
TI AGGRESSION DURING DRUG-FREE AND ANTIPSYCHOTIC TREATMENT IN INPATIENTS
WITH CHRONIC-SCHIZOPHRENIA, USING THE OVERT AGGRESSION SCALE
SO SCHIZOPHRENIA RESEARCH
LA English
DT Meeting Abstract
C1 NIMH,EXPTL THERAPEUT BRANCH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD APR
PY 1995
VL 15
IS 1-2
BP 166
EP 166
DI 10.1016/0920-9964(95)95515-B
PG 1
WC Psychiatry
SC Psychiatry
GA QN952
UT WOS:A1995QN95200492
ER
PT J
AU WYATT, RJ
AF WYATT, RJ
TI EARLY INTERVENTION IN SCHIZOPHRENIA IMPROVES THE LONG-TERM COURSE OF THE
ILLNESS
SO SCHIZOPHRENIA RESEARCH
LA English
DT Meeting Abstract
C1 NIMH,NEUROSCI CTR ST ELIZABETHS,NEUROPSYCHIAT BRANCH,WASHINGTON,DC 20032.
NR 1
TC 1
Z9 1
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD APR
PY 1995
VL 15
IS 1-2
BP 170
EP 170
DI 10.1016/0920-9964(95)95528-H
PG 1
WC Psychiatry
SC Psychiatry
GA QN952
UT WOS:A1995QN95200503
ER
PT J
AU TORREY, EF
RAWLINGS, R
AF TORREY, EF
RAWLINGS, R
TI BIRTH SEASONALITY IN BIPOLAR DISORDER, SCHIZOPHRENIA, SCHIZOAFFECTIVE
DISORDER, AND STILLBIRTHS
SO SCHIZOPHRENIA RESEARCH
LA English
DT Meeting Abstract
C1 ST ELIZABETH HOSP,NIMH,CTR NEUROSCI,WASHINGTON,DC 20032.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD APR
PY 1995
VL 15
IS 1-2
BP 199
EP 200
DI 10.1016/0920-9964(95)95617-I
PG 2
WC Psychiatry
SC Psychiatry
GA QN952
UT WOS:A1995QN95200593
ER
PT J
AU TORREY, EF
AF TORREY, EF
TI IS SCHIZOPHRENIA INCREASING IN THE UNITED-STATES
SO SCHIZOPHRENIA RESEARCH
LA English
DT Meeting Abstract
C1 ST ELIZABETH HOSP,NIMH,CTR NEUROSCI,WASHINGTON,DC 20032.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD APR
PY 1995
VL 15
IS 1-2
BP 200
EP 200
DI 10.1016/0920-9964(95)95618-J
PG 1
WC Psychiatry
SC Psychiatry
GA QN952
UT WOS:A1995QN95200594
ER
PT J
AU LU, YY
BLAIR, DG
AF LU, YY
BLAIR, DG
TI STABLE ONCOGENIC TRANSFORMATION-INDUCED BY MICROCELL-MEDIATED
GENE-TRANSFER
SO SCIENCE IN CHINA SERIES B-CHEMISTRY LIFE SCIENCES & EARTH SCIENCES
LA English
DT Article
DE ONCOGENE; MICROCELL; CELL TRANSFORMATION; GENE MAPPING; MET
ID INSITU HYBRIDIZATION; TYROSINE KINASE; CYSTIC-FIBROSIS; CELLS; MET;
CHROMOSOME; ACTIVATION; SEQUENCES; HYBRIDS
AB Oncogenes have been identified using DNA-mediated transfection, but the size of the transferable and unrearranged DNA gene rearrangement and amplification which occur during the transfection process limit the use of the techniques. We have evaluated microcell-mediated gene transfer techniques for the transfer and analysis of dominant oncogenes. MNNG-HOS, a transformed human cell line which contained the met oncogene mapping to human chromosome 7 was infected with retroviruses carrying drug resistance markers and used to optimize microcell preparation and transfer. Stable and drug-resistant hybrids containing single human chromosomes as well as the fod of the transformed cells containing the activated met oncogene and intact human chromosomes were obtained. Hybridization analysis with probes (i.e. collA2 pJ3.11) mapping up to 1 Mb away from met shows that the cells from the individual foci contain different amounts of apparently unrearranged human DNA associated with the oncogene, and the microcell-generated transformants retain more distal markers than those observed in either DNA- or chromosome-mediated transfers. In conjunction with other techniques, microcell fusion should be useful for gene mapping as well as the study of gene function and expression in cell transformation and malignancy.
C1 NCI,MOLEC ONCOL LAB,FREDERICK,MD 21702.
RP LU, YY (reprint author), BEIJING INST CANC RES,BEIJING 100034,PEOPLES R CHINA.
NR 18
TC 0
Z9 1
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 1001-652X
J9 SCI CHINA SER B
JI Sci. China Ser. B-Chem. Life Sci. Earth Sci.
PD APR
PY 1995
VL 38
IS 4
BP 448
EP 456
PG 9
WC Chemistry, Multidisciplinary
SC Chemistry
GA QY027
UT WOS:A1995QY02700008
PM 7786413
ER
PT J
AU WRIGHT, LL
MCNELLIS, D
AF WRIGHT, LL
MCNELLIS, D
TI NATIONAL-INSTITUTE-OF-CHILD-HEALTH-AND-HUMAN-DEVELOPMENT
(NICHD)-SPONSORED PERINATAL RESEARCH NETWORKS
SO SEMINARS IN PERINATOLOGY
LA English
DT Review
ID RESPIRATORY-DISTRESS SYNDROME; SYNTHETIC SURFACTANT; TRIAL; BIRTH;
MULTICENTER; PHYSICIANS; INFANTS; GRAMS
RP WRIGHT, LL (reprint author), NICHHD,RM 4B03F,6100 EXECUT BLVD,ROCKVILLE,MD 20852, USA.
NR 36
TC 6
Z9 6
U1 0
U2 3
PU W B SAUNDERS CO
PI PHILADELPHIA
PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA
19106-3399
SN 0146-0005
J9 SEMIN PERINATOL
JI Semin. Perinatol.
PD APR
PY 1995
VL 19
IS 2
BP 112
EP 123
DI 10.1016/S0146-0005(05)80031-X
PG 12
WC Obstetrics & Gynecology; Pediatrics
SC Obstetrics & Gynecology; Pediatrics
GA QV878
UT WOS:A1995QV87800003
PM 7604302
ER
PT J
AU COLE, GW
SINDELAR, WF
AF COLE, GW
SINDELAR, WF
TI IATROGENIC TRANSPLANTATION OF OSTEOSARCOMA
SO SOUTHERN MEDICAL JOURNAL
LA English
DT Note
ID METASTASES
AB We report a case in which a patient having curettage and resection of a presumed benign lesion of the tibia (later recognized as osteosarcoma) had probable iatrogenic transplantation of tumor to the contralateral iliac crest, which had served as a donor site for bone chips used to pack the tibial lesion. The patient later had above-knee amputation for the primary tumor and eventually required contralateral hemipelvectomy when tumor developed in the iliac crest donor site. We discuss the literature of tumor transplantation and seeding in operative settings and stress the clinical importance of avoiding possible tumor contamination of operative fields by meticulous instrument changes and by isolation of multiple surgical fields.
C1 NCI,SURG BRANCH,BETHESDA,MD 20892.
NR 12
TC 13
Z9 14
U1 0
U2 0
PU SOUTHERN MEDICAL ASSN
PI BIRMINGHAM
PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219
SN 0038-4348
J9 SOUTHERN MED J
JI South.Med.J.
PD APR
PY 1995
VL 88
IS 4
BP 485
EP 488
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA QT269
UT WOS:A1995QT26900023
PM 7716608
ER
PT J
AU POTEMBER, RS
MATSUZAWA, M
LIESI, P
AF POTEMBER, RS
MATSUZAWA, M
LIESI, P
TI CONDUCTING NETWORKS FROM CULTURED-CELLS ON SELF-ASSEMBLED MONOLAYERS
SO SYNTHETIC METALS
LA English
DT Article; Proceedings Paper
CT International Conference on Science and Technology of Synthetic Metals
(ICSM 94)
CY JUL 24-29, 1994
CL SEOUL, SOUTH KOREA
ID COPLANAR MOLECULAR ASSEMBLIES; GROWTH; OUTGROWTH
AB A combination of photolithographic and chemical techniques were used to prepare biologically active patterned substrates to guide the development of neurons in culture. A synthetic peptide, derived from the B2 chain of laminin was chemically attached to patterned silicon surfaces to promote the development and guidance of embryonic rat hippocampal neurons. On parallel lines, neurons developed a mature bipolar morphology. These modified surfaces may be an important element of future biosensors and neural prosthetic devices.
C1 NIAAA,MOLEC & CELLULAR NEUROBIOL LAB,ROCKVILLE,MD 20852.
RP POTEMBER, RS (reprint author), JOHNS HOPKINS UNIV,APPL PHYS LAB,LAUREL,MD 20723, USA.
NR 8
TC 2
Z9 2
U1 0
U2 0
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0379-6779
J9 SYNTHETIC MET
JI Synth. Met.
PD APR 1
PY 1995
VL 71
IS 1-3
BP 1997
EP 1999
DI 10.1016/0379-6779(94)03137-U
PG 3
WC Materials Science, Multidisciplinary; Physics, Condensed Matter; Polymer
Science
SC Materials Science; Physics; Polymer Science
GA QT326
UT WOS:A1995QT32600195
ER
PT J
AU GOMEZ, DE
NASON, AM
THORGEIRSSON, UP
AF GOMEZ, DE
NASON, AM
THORGEIRSSON, UP
TI THROMBIN TREATMENT OF ENDOTHELIAL-CELLS STIMULATES ADHESION OF
ONCOGENE-TRANSFORMED BUT NOT PARENT RAT-LIVER EPITHELIAL-CELLS
SO THROMBOSIS RESEARCH
LA English
DT Note
DE THROMBIN; ADHESION; ENDOTHELIAL CELLS; TUMOR CELLS
ID METASTASIS INVIVO; TUMOR-CELLS; INVITRO; NEUTROPHILS; PLATELETS;
PROTEINS; RECEPTOR; BINDING; GMP-140
RP GOMEZ, DE (reprint author), NCI,DIV CANC ETIOL,OFF DIRECTOR,BLDG 37,ROOM 2D-02,BETHESDA,MD 20892, USA.
OI Gomez, Daniel E/0000-0002-8629-0787
NR 21
TC 1
Z9 1
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0049-3848
J9 THROMB RES
JI Thromb. Res.
PD APR 1
PY 1995
VL 78
IS 1
BP 87
EP 94
DI 10.1016/0049-3848(95)00037-2
PG 8
WC Hematology; Peripheral Vascular Disease
SC Hematology; Cardiovascular System & Cardiology
GA QN155
UT WOS:A1995QN15500007
PM 7778069
ER
PT J
AU CUNNINGHAM, ML
PIPPIN, LL
ANDERSON, NL
WENK, ML
AF CUNNINGHAM, ML
PIPPIN, LL
ANDERSON, NL
WENK, ML
TI THE HEPATOCARCINOGEN METHAPYRILENE BUT NOT THE ANALOG PYRILAMINE INDUCES
SUSTAINED HEPATOCELLULAR REPLICATION AND PROTEIN ALTERATIONS IN F344
RATS IN A 13-WEEK FEED STUDY
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
ID CELL-PROLIFERATION; GENOTOXIC CARCINOGENESIS; CHEMICAL CARCINOGENESIS;
DNA-SYNTHESIS; LIVER-TUMORS; TOXICITY; HYDROCHLORIDE; MUTAGENICITY;
EXPOSURE; RODENTS
AB Methapyrilene (MPH) was a widely used antihistamine until it was found to produce hepatocellular carcinoma and cholangiocarcinoma in Fischer 344 rats. The structurally similar antihistamine pyrilamine (PYR) was marginally or noncarcinogenic in a similar study. The peroxisome proliferator Wy-14,643 was included in this study as a positive control. As part of a program to investigate the mechanisms whereby structurally similar chemicals produce different toxicities, we studied these three chemicals for the induction of cell proliferation in the liver of F344 rats. Male rats were treated for up to 13 weeks with feed dosed with MPH (HCl salt) at 0, 50, 100, 250, or 1000 ppm or PYR (maleate salt) at 1000 ppm to duplicate the route of administration and high-dose groups used in the carcinogenesis assay. In addition, the nongenotoxic hepatocarcinogen peroxisome proliferator Wy-14,643 was included as a positive cell-proliferating chemical. Cell proliferation was quantitated by measuring the incorporation of bromodeoxyuridine (BrDU) administered by osmotic minipump for 7 days and the appearance of proliferating cell nuclear antigen (PCNA) immunohistochemically. The BrDU-labeling index showed a large and sustained increase in rats treated with MPH at 250 and 1000 ppm, sustaining greater than 50% labeling in the higher dose group of 4-, 6-, and 13-week treatment groups. PYR at 1000 ppm demonstrated no significant increase in labeling above control levels at any time point. PCNA-labeling indexes showed similar but reduced increases for MPH and were comparable to control for the PYR dose groups. Two-dimensional gel electrophoresis was used for the detection of quantitative changes in gene expression and qualitative changes in the charges of specific mitochondrial and cytosolic proteins. Quantitative changes in 32 proteins induced by MPH and 39 changes induced by Wy-14,643 were detected throughout the 13-week study. Specific mitochondrial protein charge shifts were associated with high-dose MPH treatment that were not observed in animals treated with Wy-14,643. PYR induced no significant qualitative or quantitative protein alterations. Hepatocellular proliferation of the large magnitude observed following dietary administration of MPH, and not PYR may contribute to the mechanism of carcinogenesis of MPH. (C) 1995 Academic Press, Inc.
C1 PATHOL ASSOCIATES INC,FREDERICK,MD 21701.
LARGE SCALE BIOL CORP,ROCKVILLE,MD 20850.
MICROBIOL ASSOCIATES INC,ROCKVILLE,MD 20850.
RP CUNNINGHAM, ML (reprint author), NIEHS,CHEM BRANCH,POB 12233,MAIL DROP B3-10,RES TRIANGLE PK,NC 27709, USA.
NR 38
TC 35
Z9 35
U1 0
U2 1
PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
PI SAN DIEGO
PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495
SN 0041-008X
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD APR
PY 1995
VL 131
IS 2
BP 216
EP 223
DI 10.1006/taap.1995.1064
PG 8
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA QU176
UT WOS:A1995QU17600005
PM 7716764
ER
PT J
AU KAYAMA, F
YOSHIDA, T
ELWELL, MR
LUSTER, MI
AF KAYAMA, F
YOSHIDA, T
ELWELL, MR
LUSTER, MI
TI ROLE OF TUMOR-NECROSIS-FACTOR-ALPHA IN CADMIUM-INDUCED HEPATOTOXICITY
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
ID LIVER MACROPHAGES; GENE-EXPRESSION; ACETAMINOPHEN HEPATOTOXICITY;
ACTIVATED MACROPHAGES; ALCOHOLIC HEPATITIS; ENDOTHELIAL-CELLS; POTENTIAL
ROLE; KUPFFER CELLS; INTERLEUKIN-1; MICE
AB Liver and kidney injury following acute or chronic exposure to cadmium is well characterized. While hepatocytes and endothelial cells of the sinusoids are thought to be the primary cellular targets in the liver, ultrastructural changes may vary depending upon the exposure regimen and the time following administration. Since acute and chronic liver disease is often associated with the presence of cytokines, we investigated the role of proinflammatory cytokines in cadmium-induced hepatotoxicity. Supernatants from cultured liver slices obtained from acute or subchronic cadmium-exposed rats and mice were collected and cytokine secretion was examined. In addition, mRNA transcripts for IL-1 alpha, IL-1 beta, IL-6, TNF-alpha, MIP-2, IFN-gamma, and ICAM-1 from livers of treated mice were quantitated by reverse transcription-polymerase chain reaction. Modest increases in secretion of TNF-alpha, IL-1 alpha, and IL-6 were observed in response to cadmium which were enhanced in LPS-primed mice. Additionally, cadmium exposure increased IL-1 alpha, IL-1 beta, TNF-alpha, MIP-2, IL-6, and ICAM-1 mRNA transcripts in the liver. Immunohistochemical analysis revealed that TNF-alpha was associated with nonparenchymal cells in livers of cadmium-treated mice. Cadmium exposure produced a marked increase in plasma hepatocellular enzyme levels (i.e., AST, LDH, SDH), acute phase proteins (i.e., serum amyloid A), and foci formation in the liver, while focal inflammation and serum amyloid A (SAA) secretion, but not plasma enzymes, were further increased in cadmium-exposed mice primed with LPS. SAA secretion and focal inflammation were prevented by pretreatment with antibodies to TNF-alpha, indicating that these pathological manifestations are cytokine dependent. These data indicate that TNF-alpha, released from nonparenchymal cells as well as associated cytokines, are responsible for certain manifestations observed with cadmium-induced hepatotoxicity.
C1 NIEHS,ENVIRONM TOXICOL BRANCH,RES TRIANGLE PK,NC 27709.
UNIV OCCUPAT & ENVIRONM HLTH,DEPT ENVIRONM HLTH,KITAKYUSHU,FUKUOKA 807,JAPAN.
TOKAI UNIV,SCH MED,DEPT ENVIRONM HLTH,ISEHARA,KANAGAWA 25911,JAPAN.
RP KAYAMA, F (reprint author), NIEHS,ENVIRONM IMMUNOL & NEUROBIOL SECT,RES TRIANGLE PK,NC 27709, USA.
NR 45
TC 136
Z9 136
U1 0
U2 8
PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
PI SAN DIEGO
PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495
SN 0041-008X
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD APR
PY 1995
VL 131
IS 2
BP 224
EP 234
DI 10.1006/taap.1995.1065
PG 11
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA QU176
UT WOS:A1995QU17600006
PM 7536360
ER
PT J
AU HOLLADAY, SD
SMITH, BJ
LUSTER, MI
AF HOLLADAY, SD
SMITH, BJ
LUSTER, MI
TI B-LYMPHOCYTE PRECURSOR CELLS REPRESENT SENSITIVE TARGETS OF T2 MYCOTOXIN
EXPOSURE
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
ID DIETARY T-2 TOXIN; THYMIC ATROPHY; MICE; INFECTION; RESISTANCE;
TOXICITY; EXPRESSION; FUSARIUM; DNA
AB Exposure of experimental animals and humans to the Fusarium trichothecene metabolite, T2 toxin, has been associated with a variety of immunosuppressive effects, including altered parameters of humoral-mediated immunity. Although T2 toxin is cytotoxic in vitro to lymphocytic cells, limited information is presently available regarding the contribution of such a mechanism to immunosuppression in vivo, or to potential immune cell targets. In the present report, subchronic T2 toxin treatment of timed-pregnant B6C3F1 mice resulted in significant and selective depletion of fetal liver cells expressing low levels of surface CD44 and CD45 antigens, suggestive of possible lymphoid progenitor cell sensitivity to this agent. Evaluation of CD45R antigen expression in fetal liver supported such a hypothesis, demonstrating a significant reduction in fetal liver B lymphocytic cells in animals exposed to T2 toxin. Subsequent in vitro T2 toxin exposure of fetal liver cells enriched for prolymphocytes by differential density gradient centrifugation demonstrated the presence of a highly sensitive subpopulation of cells that was eliminated in a selective, and near-complete, manner by T2 toxin exposure. This sensitive cell population was observed to have light-scatter characteristics of CD45R(+) B-lineage lymphocytes. Additional studies in adult mice demonstrated a reduction in CD44(lo) and CD45R(+) bone marrow cells similar to that seen in fetal liver, indicating that T2 toxin may also target immature B lymphocytes in this hematopoietic compartment. Taken together, these data suggest that the precursors of B cells may represent, for unknown reasons, highly sensitive targets of T2 toxin exposure. (C) 1995 Academic Press, Inc.
C1 NIEHS,ENVIRONM IMMUNOL & MICROBIOL SECT,RES TRIANGLE PK,NC 27709.
RP HOLLADAY, SD (reprint author), VIRGINIA POLYTECH INST & STATE UNIV,VIRGINIA MARYLAND REG COLL VET MED,BLACKSBURG,VA 24061, USA.
NR 31
TC 26
Z9 27
U1 0
U2 0
PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
PI SAN DIEGO
PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495
SN 0041-008X
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD APR
PY 1995
VL 131
IS 2
BP 309
EP 315
DI 10.1006/taap.1995.1073
PG 7
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA QU176
UT WOS:A1995QU17600014
PM 7716771
ER
PT J
AU GRIFFIN, RJ
BURKA, LT
CUNNINGHAM, ML
AF GRIFFIN, RJ
BURKA, LT
CUNNINGHAM, ML
TI ACTIVITY OF HEPATIC DRUG-METABOLIZING-ENZYMES FOLLOWING OXAZEPAM-DOSED
FEED TREATMENT IN B6C3F1 MICE
SO TOXICOLOGY LETTERS
LA English
DT Article
DE OXAZEPAM; BENZODIAZEPINE; ENZYME INDUCTION; CYTOCHROME P450
ID MOUSE-LIVER; RAT-LIVER; INDUCTION; DIAZEPAM; SERIES
AB Oxazepam has been determined to be a potent hepatocarcinogen in mice. Evidence in the literature indicates that oxazepam is capable of inducing drug metabolizing enzymes in rodents and an association between enzyme induction and carcinogenesis has been proposed for other compounds such as phenobarbital. We examined the pattern of enzyme induction that occurs under bioassay conditions in male B6C3F1 mice. The results indicate that oxazepam is capable of inducing multiple drug metabolizing enzymes under bioassay conditions. Closer examination of the most induced samples suggests that oxazepam is a phenobarbital-type enzyme inducer.
RP GRIFFIN, RJ (reprint author), NIEHS,CHEM BRANCH,MD C3-02,POB 12233,RES TRIANGLE PK,NC 27709, USA.
NR 25
TC 12
Z9 12
U1 0
U2 0
PU ELSEVIER SCI PUBL IRELAND LTD
PI CLARE
PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE,
IRELAND
SN 0378-4274
J9 TOXICOL LETT
JI Toxicol. Lett.
PD APR
PY 1995
VL 76
IS 3
BP 251
EP 256
DI 10.1016/0378-4274(95)80010-B
PG 6
WC Toxicology
SC Toxicology
GA QX651
UT WOS:A1995QX65100009
PM 7762012
ER
PT J
AU JEFFERSON, WN
SHIGETA, H
NEWBOLD, RR
AF JEFFERSON, WN
SHIGETA, H
NEWBOLD, RR
TI ENHANCED CHEMILUMINESCENT DETECTION OF FLUORESCEIN-LABELED NUCLEIC-ACIDS
COMPARED TO P-32 LABELING METHODS - LACTOFERRIN AS A MARKER
SO TOXICOLOGY METHODS
LA English
DT Article
DE NORTHERN BLOTTING; ENHANCED CHEMILUMINESCENCE (ECL); FLUORESCEIN RANDOM
PRIME LABELING; LACTOFERRIN (LF); P-32 (P-32)
ID REPRODUCTIVE-TRACT; RIBONUCLEIC-ACID; MOUSE; PROTEIN
AB This study evaluated the ability of nonradioactive, sensitive Northern blotting methods to detect small amounts of messenger RNA. The more traditional P-32 labeling and detection method was compared to enhanced chemiluminescent (ECL) detection of fluorescein labeled nucleic acids, The results show that the ECL method is equally as sensitive as P-32, and both methods are highly quantitative by image analysis. The fluorescein generated probes can be stored for several months as compared to several days storage for P-32 labeled probes. The ECL method of detecting fluorescein labeled nucleic acid probes should prove useful for many applications in biochemistry, molecular biology, and toxicology.
C1 NIEHS,ENVIRONM TOXICOL PROGRAM,TOXICOL BRANCH,REPROD TOXICOL GRP,RES TRIANGLE PK,NC 27709.
NIEHS,REPROD LAB,DEV ENDOCRINOL & PHARMACOL SECT,RES TRIANGLE PK,NC 27709.
NIEHS,DIV INTRAMURAL RES,DEV TOXICOL ENVIRONM BIOL & MED PROGRAM,RES TRIANGLE PK,NC 27709.
NR 8
TC 2
Z9 2
U1 0
U2 0
PU TAYLOR & FRANCIS
PI BRISTOL
PA 1900 FROST ROAD, SUITE 101, BRISTOL, PA 19007-1598
SN 1051-7235
J9 TOXICOL METHOD
JI Toxicol. Method.
PD APR-JUN
PY 1995
VL 5
IS 2
BP 81
EP 87
DI 10.3109/15376519509045903
PG 7
WC Toxicology
SC Toxicology
GA RV750
UT WOS:A1995RV75000002
ER
PT J
AU LENFANT, C
AF LENFANT, C
TI NEW GENETIC APPROACHES - ESTABLISHING RESOURCES FOR RESEARCH
SO TRANSFUSION
LA English
DT Note
RP LENFANT, C (reprint author), NHLBI,BLDG 31,ROOM 5A52,BETHESDA,MD 20892, USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC BLOOD BANKS
PI BETHESDA
PA 8101 GLENBROOK RD, BETHESDA, MD 20814-2749
SN 0041-1132
J9 TRANSFUSION
JI Transfusion
PD APR
PY 1995
VL 35
IS 4
BP 346
EP 347
DI 10.1046/j.1537-2995.1995.35495216085.x
PG 2
WC Hematology
SC Hematology
GA QQ300
UT WOS:A1995QQ30000012
PM 7701554
ER
PT J
AU CANNON, GW
REMMERS, EF
WILDER, RL
HIBBS, JB
GRIFFITHS, MM
AF CANNON, GW
REMMERS, EF
WILDER, RL
HIBBS, JB
GRIFFITHS, MM
TI NITRIC-OXIDE PRODUCTION DURING ADJUVANT-INDUCED ARTHRITIS IS ASSOCIATED
WITH TUMOR-NECROSIS-FACTOR GENOTYPE
SO TRANSPLANTATION PROCEEDINGS
LA English
DT Article; Proceedings Paper
CT 10th International Workshop on Alloantigenic Systems in the Rat
CY AUG 23-26, 1994
CL HOKKAIDO UNIV, SAPPORO, JAPAN
SP TRANSPLANTAT SOC
HO HOKKAIDO UNIV
C1 UNIV UTAH,DEPT MED,DIV RHEUMATOL,SALT LAKE CITY,UT 84112.
UNIV UTAH,DEPT MED,DIV INFECT DIS,SALT LAKE CITY,UT 84112.
NIAMSD,ARTHRITIS & RHEUMATISM BRANCH,INFLAMMATORY JOINT DIS SECT,BETHESDA,MD 20892.
RP CANNON, GW (reprint author), VET AFFAIRS MED CTR,SALT LAKE CITY,UT 84148, USA.
NR 4
TC 2
Z9 2
U1 0
U2 0
PU APPLETON & LANGE
PI E NORWALK
PA 25 VAN ZANT ST, E NORWALK, CT 06855
SN 0041-1345
J9 TRANSPLANT P
JI Transplant. Proc.
PD APR
PY 1995
VL 27
IS 2
BP 1543
EP 1544
PG 2
WC Immunology; Surgery; Transplantation
SC Immunology; Surgery; Transplantation
GA QT729
UT WOS:A1995QT72900020
PM 7725404
ER
PT J
AU KOONIN, EV
AF KOONIN, EV
TI A PROTEIN SPLICE-JUNCTION MOTIF IN HEDGEHOG FAMILY PROTEINS
SO TRENDS IN BIOCHEMICAL SCIENCES
LA English
DT Note
ID ARCHAEA DNA-POLYMERASE; ADENOSINE-TRIPHOSPHATASE; INTERVENING SEQUENCES;
CATALYTIC SUBUNIT; GENE; ENDONUCLEASES; INTRONS; VMA1
RP KOONIN, EV (reprint author), NATL LIB MED,NATL CTR BIOTECHNOL INFORMAT,BETHESDA,MD 20894, USA.
NR 24
TC 40
Z9 40
U1 0
U2 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB
SN 0968-0004
J9 TRENDS BIOCHEM SCI
JI Trends Biochem.Sci.
PD APR
PY 1995
VL 20
IS 4
BP 141
EP 142
DI 10.1016/S0968-0004(00)88989-6
PG 2
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QU082
UT WOS:A1995QU08200004
PM 7770912
ER
PT J
AU BOMAN, AL
KAHN, RA
AF BOMAN, AL
KAHN, RA
TI ARF PROTEINS - THE MEMBRANE TRAFFIC POLICE
SO TRENDS IN BIOCHEMICAL SCIENCES
LA English
DT Review
ID ADP-RIBOSYLATION FACTOR; GTP-BINDING-PROTEIN; GOLGI MEMBRANES; DEPENDENT
BINDING; PHOSPHOLIPASE-D; BETA-COP; FAMILY; MYRISTOYLATION; DROSOPHILA;
TRANSPORT
AB Cofactor for cholera toxin; activator of phospholipase D; regulator of coat-protein assembly; inhibitor of membrane traffic; ability to cause expansion of the endoplasmic reticulum and vesiculation of the Golgi; sensitivity to membrane phospholipids - each of these activities has been attributed to Arf proteins. Can a single molecular mechanism link them all?
RP BOMAN, AL (reprint author), NCI,DIV CANC TREATMENT,BIOL CHEM LAB,DEV THERAPEUT PROGRAM,BETHESDA,MD 20892, USA.
NR 38
TC 223
Z9 228
U1 0
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB
SN 0968-0004
J9 TRENDS BIOCHEM SCI
JI Trends Biochem.Sci.
PD APR
PY 1995
VL 20
IS 4
BP 147
EP 150
DI 10.1016/S0968-0004(00)88991-4
PG 4
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QU082
UT WOS:A1995QU08200006
PM 7770914
ER
PT J
AU HENGEN, PN
AF HENGEN, PN
TI METHODS AND REAGENTS - CARING FOR YOUR HYBRIDIZATION MEMBRANES
SO TRENDS IN BIOCHEMICAL SCIENCES
LA English
DT Editorial Material
RP HENGEN, PN (reprint author), NCI,FREDERICK CANC RES & DEV CTR,FREDERICK,MD 21702, USA.
NR 3
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB
SN 0968-0004
J9 TRENDS BIOCHEM SCI
JI Trends Biochem.Sci.
PD APR
PY 1995
VL 20
IS 4
BP 160
EP 161
DI 10.1016/S0968-0004(00)88994-X
PG 2
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QU082
UT WOS:A1995QU08200013
PM 7770917
ER
PT J
AU LIPTON, SA
BRENNEMAN, DE
SILVERSTEIN, FS
MASLIAH, E
MUCKE, L
AF LIPTON, SA
BRENNEMAN, DE
SILVERSTEIN, FS
MASLIAH, E
MUCKE, L
TI GP120 AND NEUROTOXICITY IN-VIVO
SO TRENDS IN PHARMACOLOGICAL SCIENCES
LA English
DT Letter
ID ENVELOPE
C1 CHILDRENS HOSP, BOSTON, MA 02115 USA.
NICHHD, DEV & MOLEC PHARMACOL SECT, BETHESDA, MD 20892 USA.
UNIV MICHIGAN, DEPT NEUROL, ANN ARBOR, MI 48109 USA.
UNIV CALIF SAN DIEGO, DEPT NEUROSCI, LA JOLLA, CA 92093 USA.
Scripps Res Inst, DEPT NEUROPHARMACOL, LA JOLLA, CA 92037 USA.
RP LIPTON, SA (reprint author), HARVARD UNIV, SCH MED, DEPT NEUROL, BOSTON, MA 02115 USA.
NR 10
TC 15
Z9 15
U1 0
U2 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB
SN 0165-6147
J9 TRENDS PHARMACOL SCI
JI Trends Pharmacol. Sci.
PD APR
PY 1995
VL 16
IS 4
BP 122
EP 122
DI 10.1016/S0165-6147(00)88998-1
PG 1
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA QY937
UT WOS:A1995QY93700003
PM 7610496
ER
PT J
AU HUNT, JA
DISKO, MM
BEHAL, SK
LEAPMAN, RD
AF HUNT, JA
DISKO, MM
BEHAL, SK
LEAPMAN, RD
TI ELECTRON-ENERGY-LOSS CHEMICAL IMAGING OF POLYMER PHASES
SO ULTRAMICROSCOPY
LA English
DT Article; Proceedings Paper
CT Workshop on Materials Science Opportunities for Field Emission Electron
Sources
CY JAN 05-08, 1994
CL SCOTTSDALE, AZ
SP NATL SCI FDN, CTR HIGH RESOLUT ELECTRON MICROSCOPY, ARIZONA STATE UNIV, CTR SOLID STATE SCI
ID POLYETHYLENE POLYSTYRENE BLENDS; BLOCK COPOLYMER; DIBLOCK COPOLYMER;
MOLECULAR DESIGN; SPECTROSCOPY; HOMOPOLYMER; MORPHOLOGY; MICROSCOPY;
SURFACES; SYSTEMS
AB Transmission electron energy-loss spectrum-imaging investigations of a low-density polyethylene blend with polystyrene show that chemical imaging is possible with high spatial resolution for polymers in a dedicated scanning transmission electron microscope. Spectrum-imaging provides highly accurate phase identifications without staining. This polymer blend also contains a small amount of styrene-hydrogenated polyisoprene diblock copolymer (Kraton G 1701) as a compatibilizer. Detection of this compatibilizer at interfaces was expected to be difficult because of its chemical similarity to the pure components. We were unable to detect the copolymer with EELS imaging unambiguously, but were able to accurately map regions rich in either polyethylene or polystyrene. Chemical imaging techniques that we develop here are of use for polymer mixtures that exhibit variations in either carbon bonding or distribution of heteroatoms.
C1 EXXON RES & ENGN CO,ANNANDALE,NJ 08801.
NIH,BETHESDA,MD 20892.
RP HUNT, JA (reprint author), GATAN INC,RES & DEV,PLEASANTON,CA 94588, USA.
NR 30
TC 26
Z9 26
U1 0
U2 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-3991
J9 ULTRAMICROSCOPY
JI Ultramicroscopy
PD APR
PY 1995
VL 58
IS 1
BP 55
EP 64
DI 10.1016/0304-3991(94)00178-P
PG 10
WC Microscopy
SC Microscopy
GA QV106
UT WOS:A1995QV10600008
ER
PT J
AU CARTER, HB
PEARSON, JD
WACLAWIW, Z
METTER, EJ
CHAN, DW
GUESS, HA
WALSH, PC
AF CARTER, HB
PEARSON, JD
WACLAWIW, Z
METTER, EJ
CHAN, DW
GUESS, HA
WALSH, PC
TI PROSTATE-SPECIFIC ANTIGEN VARIABILITY IN MEN WITHOUT PROSTATE-CANCER -
EFFECT OF SAMPLING INTERVAL ON PROSTATE-SPECIFIC ANTIGEN VELOCITY
SO UROLOGY
LA English
DT Article
AB Objectives. To evaluate short-term and long-term variability between prostate-specific antigen (PSA) measurements to determine the most appropriate PSA sampling interval and rate of PSA change (PSA velocity) to distinguish between men with and without prostate cancer.
Methods. Retrospective study of PSA variability and PSA velocity in three groups of men without a diagnosis of prostate cancer and PSA levels less than 10 ng/mL: 56 men with a histologic diagnosis of benign prostatic hyperplasia (BPH; histologic BPH group) and 527 men with no history of cancer (noncancer group) who were part of the Baltimore Longitudinal Study of Aging and had PSA sampled at 2-year intervals (long-term), and 223 men with a clinical diagnosis of BPH (clinical BPH group) who had PSA sampled at 3-month intervals (short-term). PSA variability (deviation between consecutive measurements) and PSA velocity based on both two consecutive measurements and three consecutive measurements (average velocity) were calculated for each study group.
Results. PSA velocity is the deviation in PSA measurements relative to the elapsed time between the measurements. Because the variability in PSA between measurements was similar for the groups, the major factors that influenced PSA velocity were the sampling interval between PSA measurements, and to a lesser extent, the number of repeat PSA measurements. The 99th percentile for PSA velocity was 0.7 (histologic BPH group) and 0.75 ng/mL per year for the noncancer group when three measurements with a 24-month PSA sampling interval were used. However, the 99th percentile for PSA velocity was 5.8 and 2.4 ng/mL per year when three measurements with 3-month and 6-month PSA sampling intervals were used. Using three measurements, the percentage of subjects with a PSA velocity more than 0.75 ng/mL per year was 1% for the groups with a 24-month PSA sampling interval and 28% and 17% for 3-month and 6-month PSA sampling intervals, respectively. The 99th percentile for PSA velocity and the percentage of subjects with a PSA velocity more than 0.75 ng/mL per year was higher using two measurements compared to three measurements regardless of PSA sampling interval.
Conclusions. PSA velocity is inversely related to the interval between PSA measurements. A PSA velocity more than 0.75 ng/mL per year is useful in distinguishing between men with and without prostate cancer when: (1) velocity is based on three consecutive measurements; and (2) PSA is sampled long-term (2 years) but not short-term (3 to 6 months).
C1 JOHNS HOPKINS UNIV HOSP,SCH MED,JAMES BUCHANAN BRADY UROL INST,DEPT PATHOL,BALTIMORE,MD 21287.
NIA,GERONTOL RES CTR,BALTIMORE,MD 21224.
MERCK RES LABS,DEPT EPIDEMIOL,BLUE BELL,PA.
RP CARTER, HB (reprint author), JOHNS HOPKINS UNIV HOSP,SCH MED,JAMES BUCHANAN BRADY UROL INST,DEPT UROL,403 MARBURG,BALTIMORE,MD 21287, USA.
NR 10
TC 107
Z9 109
U1 0
U2 1
PU CAHNERS PUBL CO
PI NEW YORK
PA 249 WEST 17 STREET, NEW YORK, NY 10011
SN 0090-4295
J9 UROLOGY
JI UROLOGY
PD APR
PY 1995
VL 45
IS 4
BP 591
EP 596
DI 10.1016/S0090-4295(99)80049-1
PG 6
WC Urology & Nephrology
SC Urology & Nephrology
GA QQ902
UT WOS:A1995QQ90200010
PM 7536366
ER
PT J
AU HSU, KHL
CROWE, JE
LUBECK, MD
DAVIS, AR
HUNG, PP
CHANOCK, RM
MURPHY, BR
AF HSU, KHL
CROWE, JE
LUBECK, MD
DAVIS, AR
HUNG, PP
CHANOCK, RM
MURPHY, BR
TI ISOLATION AND CHARACTERIZATION OF A HIGHLY ATTENUATED RESPIRATORY
SYNCYTIAL VIRUS (RSV) VACCINE CANDIDATE BY MUTAGENESIS OF THE
INCOMPLETELY ATTENUATED RSV A2 TS-1 NG-1 MUTANT VIRUS
SO VACCINE
LA English
DT Article
DE RESPIRATORY SYNCYTIAL VIRUS; LIVE VACCINE; VIRUS ATTENUATION
ID TEMPERATURE-SENSITIVE MUTANT; F-GLYCOPROTEIN; COTTON RATS; CHILDREN;
INFANTS; LIVE; IMMUNOGENICITY; INFECTION; EPITOPES; ADULTS
AB Ts-1, a temperature sensitive (ts) mutant of RSV was previously derived from RSV A2 virus by mutagenesis with 5-fluorouracil (5-FU). Ts-1 was attenuated for adult volunteers and seropositive children but retained a low level of virulence in seronegative infant vaccinees as indicated by the occurrence of upper respiratory tract disease. Ts-1 NG-1, a more defective derivative of ts-1, has produced by mutagenesis of ts-1 with nitrosoguanidine. However, ts-1 NG-1 still retained a low level of virulence for the upper respiratory tract and showed some genetic instability in chimpanzees. With renewed interest in the goal of developing a live, attenuated RSV vaccine, we have now attempted to further attenuate ts-1 NG-1 by mutagenesis with 5-FU and 5-azacytidine. Four mutants that are phenotypically different from the ts-1 NG-1 parental virus were identified. Each of the four mutants was more restricted in replication in BALB/c mice compared with the ts-1 NG-1 parental virus. One of the ts-1 NG-1 derivatives, termed A-20-4, which showed the lowest (35 degrees C) in vitro shutoff temperature and which was also completely restricted in replication in BALB/c mice, was selected for further evaluation in seronegative chimpanzees, A-20-4 did not cause rhinorrhea in chimpanzees but induced detectable titers of serum RSV neutralizing antibodies in 2 of 4 chimpanzees. Apparent complete protection to subsequent challenge with, wild-type RSV was observed in each of the four chimpanzees previously immunized with A-20-4, The ts-1 NG-1 A-20-4 mutant thus represents a promising live attenuated RSV vaccine candidate.
C1 NIAID,INFECT DIS LAB,BETHESDA,MD 20892.
RP HSU, KHL (reprint author), WYETH AYERST RES,145-R-2,POB 8299,PHILADELPHIA,PA 19101, USA.
RI Crowe, James/B-5549-2009
OI Crowe, James/0000-0002-0049-1079
NR 27
TC 10
Z9 10
U1 0
U2 2
PU BUTTERWORTH-HEINEMANN LTD
PI OXFORD
PA LINACRE HOUSE JORDAN HILL, OXFORD, OXON, ENGLAND OX2 8DP
SN 0264-410X
J9 VACCINE
JI Vaccine
PD APR
PY 1995
VL 13
IS 5
BP 509
EP 515
DI 10.1016/0264-410X(94)00002-5
PG 7
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA QR844
UT WOS:A1995QR84400013
PM 7543716
ER
PT J
AU TAYLOR, J
MEIGNIER, B
TARTAGLIA, J
LANGUET, B
VANDERHOEVEN, J
FRANCHINI, G
TRIMARCHI, C
PAOLETTI, E
AF TAYLOR, J
MEIGNIER, B
TARTAGLIA, J
LANGUET, B
VANDERHOEVEN, J
FRANCHINI, G
TRIMARCHI, C
PAOLETTI, E
TI BIOLOGICAL AND IMMUNOGENIC PROPERTIES OF A CANARYPOX-RABIES RECOMBINANT,
ALVAC RG (VCP65) IN NON-AVIAN SPECIES
SO VACCINE
LA English
DT Article
DE POXVIRUS-BASED VACCINES; CANARYPOX VIRUS (ALVAC); ALVAC-RC(VCP65);
SAFETY; IMMUNOGENICITY
ID FOWLPOX VIRUS RECOMBINANT; VACCINIA VIRUS; PROTECTIVE IMMUNITY; FUSION
PROTEIN; GLYCOPROTEIN; EXPRESSION; NYVAC; GENE
AB A canarypox-based (ALVAC) recombinant expressing the rabies G glycoprotein has been utilized to assess in vitro and in vivo biological properties of the canarypox virus vector system. In vitro studies have shown that no replication of the virus can be detected on six human-derived cell lines, nor can the virus be readily adapted to replicate on nonavian cells. Expression of the rabies G can be detected on all cell lines analyzed in the absence of productive viral replication Analysis of viral-specific DNA accumulation indicated that the block in the replication cycle in the human cell lines analyzed occurred prior to DNA replication The exact nature of the block, however, remains unknown. The concept of using a non-replicating immunization vehicle has been demonstrated through extensive in vivo studies in a range of species including non-human primates and humans. The results of such in vivo studies have exemplified the safety and immunogenicity of the ALVAC vaccine vector.
C1 PASTEUR MERIEUX SERUMS & VACCINS,F-69280 MARCY LETOILE,FRANCE.
RHONE MERIEUX,LYON 07,FRANCE.
NCI,TUMOR CELL BIOL LAB,BETHESDA,MD 20892.
NEW YORK STATE DEPT HLTH,WADSWORTH CTR LABS & RES,GRIFFIN LABS,ALBANY,NY 12201.
RP TAYLOR, J (reprint author), VIROGENET CORP,465 JORDAN RD RENSSELAER TECHNOL PK,TROY,NY 12180, USA.
NR 28
TC 82
Z9 83
U1 1
U2 2
PU BUTTERWORTH-HEINEMANN LTD
PI OXFORD
PA LINACRE HOUSE JORDAN HILL, OXFORD, OXON, ENGLAND OX2 8DP
SN 0264-410X
J9 VACCINE
JI Vaccine
PD APR
PY 1995
VL 13
IS 6
BP 539
EP 549
DI 10.1016/0264-410X(94)00028-L
PG 11
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA RB419
UT WOS:A1995RB41900004
PM 7483774
ER
PT J
AU MEISTER, GE
ROBERTS, CGP
BERZOFSKY, JA
DEGROOT, AS
AF MEISTER, GE
ROBERTS, CGP
BERZOFSKY, JA
DEGROOT, AS
TI 2 NOVEL T-CELL EPITOPE PREDICTION ALGORITHMS BASED ON MHC-BINDING MOTIFS
- COMPARISON OF PREDICTED AND PUBLISHED EPITOPES FROM
MYCOBACTERIUM-TUBERCULOSIS AND HIV PROTEIN SEQUENCES
SO VACCINE
LA English
DT Article
DE MHC-BINDING; T-CELL EPITOPES; VACCINE
ID CYTOTOXIC LYMPHOCYTES-T; CLASS-II MOLECULES; ALLELE-SPECIFIC MOTIFS;
HEAT-SHOCK PROTEIN; IMMUNODOMINANT EPITOPE; ANCHOR RESIDUES; B-CELL;
LISTERIA-MONOCYTOGENES; 65-KILODALTON PROTEIN; REVERSE-TRANSCRIPTASE
AB We have designed two computer-based algorithms for T cell epitope prediction, OptiMer and EpiMer, which incorporate current knowledge of MHC-binding motifs. OptiMer locates amphipathic segments of protein antigens with a high density of MHC-binding motifs. EpiMer identifies peptides with a high density of MHC-binding motifs alone. These algorithms exploit the striking tendency for MHC-binding motifs to cluster within short segments of each protein. Putative epitopes predicted by these algorithms contain motifs corresponding to many different MHC alleles, and may contain both class I and class II motifs, features thought to be ideal for the peptide components of synthetic subunit vaccines. In this study, we describe the use of OptiMer and EpiMer for the prediction of putative T cell epitopes from Mycobacterium tuberculosis and human immunodeficiency virus protein antigens, and demonstrate that these two algorithms may provide sensitive and efficient means for the prediction of promiscuous T cell epitopes that may be critical to the development of vaccines against these and other pathogens.
C1 NCI,METAB BRANCH,MOLEC IMMUNOGENET & VACCINE RES SECT,BETHESDA,MD 20892.
RP MEISTER, GE (reprint author), BROWN UNIV,TB HIV RES LAB,PROVIDENCE,RI 02912, USA.
OI De Groot, Annie/0000-0001-5911-1459
FU NIAID NIH HHS [R01-AI35271]
NR 79
TC 115
Z9 119
U1 0
U2 2
PU BUTTERWORTH-HEINEMANN LTD
PI OXFORD
PA LINACRE HOUSE JORDAN HILL, OXFORD, OXON, ENGLAND OX2 8DP
SN 0264-410X
J9 VACCINE
JI Vaccine
PD APR
PY 1995
VL 13
IS 6
BP 581
EP 591
DI 10.1016/0264-410X(94)00014-E
PG 11
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA RB419
UT WOS:A1995RB41900009
PM 7483779
ER
PT J
AU LIMJOCO, T
NIHRANE, A
SILVER, J
AF LIMJOCO, T
NIHRANE, A
SILVER, J
TI RESISTANCE TO RETROVIRAL INFECTION IN TRANSGENIC AND BONE-MARROW
CHIMERIC MICE CONTAINING FV4-ENV-EXPRESSING HEMATOPOIETIC-CELLS
SO VIROLOGY
LA English
DT Article
ID MURINE LEUKEMIA-VIRUS; FRIEND-VIRUS; ERYTHROLEUKEMIA-CELLS;
ENDOPLASMIC-RETICULUM; SURFACE ANTIGENS; FV-4 RESISTANCE;
DOWN-REGULATION; RFV-3 GENE; EXPRESSION; CD4
AB Mice and chickens that inherit certain retroviral envelope genes are resistant to infection with related retroviruses. Previously, we described two transgenic mouse strains bearing a retroviral envelope gene, Fv4 that confers resistance to infection with ecotropic retroviruses (T. I. Limjoco et al., 1993, 1. Virol 67, 4163-4168). Here, we present results with these and an additional transgenic strain that show that (1) the level of resistance is correlated with level of expression of the transgene, (2) low-level expression of the transgene is associated with an unexpected and possibly immune-mediated phenotype of recovery from viremia, (3) resistance can be transferred by bone marrow transplantation and is ''dominant'' in chimeras containing mixtures of transgenic resistant plus control bone marrow, and (4) transplantation after infection with Friend Virus is much less effective than transplantation before infection. We discuss the implications of these results for gene therapy of retroviral infection.
C1 NIAID,MOLEC MICROBIOL LAB,BETHESDA,MD 20892.
OI Silver, Jonathan/0000-0001-9231-6368
NR 39
TC 9
Z9 9
U1 0
U2 0
PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
PI SAN DIEGO
PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495
SN 0042-6822
J9 VIROLOGY
JI Virology
PD APR 1
PY 1995
VL 208
IS 1
BP 75
EP 83
DI 10.1006/viro.1995.1131
PG 9
WC Virology
SC Virology
GA QQ934
UT WOS:A1995QQ93400009
PM 11831733
ER
PT J
AU KLAASSEN, VA
BOESHORE, ML
KOONIN, EV
TIAN, TY
FALK, BW
AF KLAASSEN, VA
BOESHORE, ML
KOONIN, EV
TIAN, TY
FALK, BW
TI GENOME STRUCTURE AND PHYLOGENETIC ANALYSIS OF LETTUCE INFECTIOUS YELLOWS
VIRUS, A WHITEFLY-TRANSMITTED, BIPARTITE CLOSTEROVIRUS
SO VIROLOGY
LA English
DT Article
ID STRAND RNA VIRUSES; HEAT-SHOCK PROTEINS; NUCLEOTIDE-SEQUENCE; DNA;
DOMAIN; GENE; CONSERVATION; MEMBRANE
AB We report the complete nucleotide sequences of lettuce infectious yellows virus (LIYV) RNAs 1 and 2. LIYV RNA 1 is 8118 nucleotides and includes three open reading frames (ORFs). Computer-assisted analysis of LIYV RNA 1 ORFs identified domains for a papain-like protease, methyltransferase (MTR), RNA helicase (HEL), and RNA-dependent RNA polymerase (RdRp). We suggest that the RdRp domain is expressed independently of the other replication-associated domains via a +1 ribosomal frameshift. Amino acid sequences of the MTR, HEL and RdRp show highly significant similarity to the homologous sequences from other closteroviruses and tower similarity to the respective proteins of tobamoviruses, tobraviruses, hordeiviruses, bromoviruses, and furoviruses. LIYV RNA 2 is 7193 nucleotides and includes six ORFs. These ORFs include a gene array that is characteristic of the closteroviruses: ORFs encoding a small membrane protein, a homologue of the HSP70 family of chaperone proteins, a protein whose function is unknown, the coat protein, and a diverged duplicate of the coat protein. LIYV is distinguished from the monopartite closteroviruses in the following ways: its genome consists of two RNAs, the positions of the coat protein gene and its diverged duplicate are reversed, and LIYV includes ORFs that are unrelated to ORFs found in other closteroviruses. (C) 1995 Academic Press, Inc.
C1 ASGROW SEED CO,KALAMAZOO,MI 49001.
NATL LIB MED,NATL CTR BIOTECHNOL INFORMAT,BETHESDA,MD 20894.
RP KLAASSEN, VA (reprint author), UNIV CALIF DAVIS,DEPT PLANT PATHOL,DAVIS,CA 95616, USA.
NR 45
TC 110
Z9 123
U1 0
U2 4
PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
PI SAN DIEGO
PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495
SN 0042-6822
J9 VIROLOGY
JI Virology
PD APR 1
PY 1995
VL 208
IS 1
BP 99
EP 110
DI 10.1006/viro.1995.1133
PG 12
WC Virology
SC Virology
GA QQ934
UT WOS:A1995QQ93400011
PM 11831736
ER
PT J
AU CARA, A
GUARNACCIA, F
REITZ, MS
GALLO, RC
LORI, F
AF CARA, A
GUARNACCIA, F
REITZ, MS
GALLO, RC
LORI, F
TI SELF-LIMITING, CELL TYPE-DEPENDENT REPLICATION OF AN INTEGRASE-DEFECTIVE
HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 IN HUMAN PRIMARY MACROPHAGES BUT NOT
T-LYMPHOCYTES
SO VIROLOGY
LA English
DT Article
ID MURINE LEUKEMIA-VIRUS; PROVIRAL INTEGRATION; VIRAL-DNA; INFECTION;
PROTEIN; COMPLEMENTATION; ACCUMULATION; ACTIVATION; EXPRESSION; CLEAVAGE
AB Integration of retroviral DNA into the host cell genome, catalyzed by the integrase (IN) protein, is thought to be required for replication. We show here that one IN-minus defective mutant of human immunodeficiency virus type 1 (HIV-1) is able to replicate in macrophages but not in peripheral blood lymphocytes (PBLs). Replication of the HIV-1 defective mutant, however, was inefficient and self-limiting. The absence of integration in the HIV-1 IN mutant in contrast to the wild-type implies that the replication of the IN mutant depends on the transcription of the extrachromosomal forms of viral DNA. In both PBLs and macrophages circular forms of DNA were detected at significant levels, indicating that the lack of a complete functional IN protein does not preclude nuclear import of HIV-1 DNA. Cell-associated p24 was absent in the IN-defective-infected PBLs, suggesting a transcriptional block of the extrachromosomal forms of HIV-1. These results show the existence of different strategies for HIV-1. replication depending upon the cell type, and indicate the necessity of integration of viral DNA for the self-maintained progression of the infection.
C1 NCI,TUMOR CELL BIOL LAB,BETHESDA,MD 20892.
RI Cara, Andrea/M-4865-2015
OI Cara, Andrea/0000-0003-4967-1895
NR 29
TC 50
Z9 51
U1 0
U2 0
PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
PI SAN DIEGO
PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495
SN 0042-6822
J9 VIROLOGY
JI Virology
PD APR 1
PY 1995
VL 208
IS 1
BP 242
EP 248
DI 10.1006/viro.1995.1148
PG 7
WC Virology
SC Virology
GA QQ934
UT WOS:A1995QQ93400026
PM 11831706
ER
PT J
AU MORIUCHI, M
MORIUCHI, H
DEBRUS, S
PIETTE, J
COHEN, JI
AF MORIUCHI, M
MORIUCHI, H
DEBRUS, S
PIETTE, J
COHEN, JI
TI THE ACIDIC AMINO-TERMINAL REGION OF VARICELLA-ZOSTER VIRUS OPEN READING
FRAME-4 PROTEIN IS REQUIRED FOR TRANSACTIVATION AND CAN FUNCTIONALLY
REPLACE THE CORRESPONDING REGION OF HERPES-SIMPLEX VIRUS ICP27
SO VIROLOGY
LA English
DT Note
ID COMPLETE DNA-SEQUENCE; ALPHA PROTEIN-ICP27; GENE-EXPRESSION;
TRANS-REPRESSOR; TYPE-1; PROMOTERS; ACTIVATOR; HOMOLOG; MUTANTS; ACT
AB Both varicella-zoster virus open reading frame 4 (ORF4) protein and its herpes simplex virus type 1 homolog ICP27 have highly acidic amino-terminal regions and cysteine-rich carboxy-terminal regions. To investigate the functional domains of these proteins, mutants were constructed and their transregulatory functions were tested in transient expression assays using two reporter plasmids, pTK-CAT-SV40A and pTK-CAT-synA, containing the same promoter sequences but different mRNA processing signals. ORF4 transactivates both pTK-CAT-SV40A and pTK-CAT-synA, while ICP27 transrepresses pTK-CAT-SV40A and transactivates pTK-CAT-synA. Deletion of the ORF4 amino-terminal region abolished most of the transactivating activity for pTK-CAT-synA but retained most of the transactivating activity for pTK-CAT-SV40A. Construction of chimeric ORF4-ICP27 molecules indicated that the ORF4 amino-terminal region was able to replace the corresponding region of ICP27 which is required for both transrepression of pTK-CAT-SV40A and transactivation of pTK-CAT-synA. Similarly, the ICP27 amino-terminal region was able to partially replace the corresponding region of ORF4 which is required for transactivation of pTK-CAT-synA. Thus, while ORF4 and ICP27 have different properties in transient expression assays, the aminoterminal regions of ORF4 and ICP27 are functionally homologous to each other and are important in regulating gene expression. (C) 1995 Academic Press, Inc.
C1 NIAID,CLIN INVEST LAB,MED VIROL SECT,BETHESDA,MD 20892.
UNIV LIEGE,INST PATHOL B23,DEPT MICROBIOL,FUNDAMENTAL VIROL LAB,B-4000 LIEGE,BELGIUM.
NR 36
TC 16
Z9 16
U1 0
U2 0
PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
PI SAN DIEGO
PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495
SN 0042-6822
J9 VIROLOGY
JI Virology
PD APR 1
PY 1995
VL 208
IS 1
BP 376
EP 382
DI 10.1006/viro.1995.1164
PG 7
WC Virology
SC Virology
GA QQ934
UT WOS:A1995QQ93400042
PM 11831723
ER
PT J
AU DUFFY, CJ
WURTZ, RH
AF DUFFY, CJ
WURTZ, RH
TI MECHANISM OF THE ILLUSORY TRANSFORMATION OF OPTIC FLOW-FIELDS
SO VISION RESEARCH
LA English
DT Letter
C1 NEI,SENSORIMOTOR RES LAB,BETHESDA,MD 20892.
UNIV ROCHESTER,MED CTR,DEPT NEUROL,ROCHESTER,NY 14642.
UNIV ROCHESTER,MED CTR,DEPT NEUROBIOL & ANAT,ROCHESTER,NY 14642.
UNIV ROCHESTER,MED CTR,DEPT OPHTHALMOL,ROCHESTER,NY 14642.
UNIV ROCHESTER,MED CTR,CTR VISUAL SCI,ROCHESTER,NY 14642.
NR 3
TC 2
Z9 2
U1 0
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0042-6989
J9 VISION RES
JI Vision Res.
PD APR
PY 1995
VL 35
IS 7
BP 985
EP 985
DI 10.1016/0042-6989(94)00191-N
PG 1
WC Neurosciences; Ophthalmology
SC Neurosciences & Neurology; Ophthalmology
GA QN962
UT WOS:A1995QN96200011
ER
PT J
AU MCCAIN, NL
CELLA, DF
AF MCCAIN, NL
CELLA, DF
TI CORRELATES OF STRESS IN HIV DISEASE
SO WESTERN JOURNAL OF NURSING RESEARCH
LA English
DT Article
ID GAY MEN; EVENT SCALE; AIDS; INFECTION; UNCERTAINTY; NUMBER; IMMUNE;
IMPACT; SEROPOSITIVITY; DEPRESSION
AB A group of 53 men with HIV disease participated in this correlational study of the relationships among psychological distress, quality of life, uncertainty, coping patterns, stress, and CD4+ T-lymphocyte levels. Meaningful correlations (r > .40, p < .01) indicated that higher levels of negative-impact stressful experiences were associated with more frequent use of emotion-focused coping; both higher levels of negative stress and more frequent use of emotion-focused coping were associated with lower quality of life, higher psychological distress, and more uncertainty; lower quality of life was associated with higher psychological distress and more uncertainty; and lower CD4+ counts were associated with higher levels of positive-impact stressful experiences.
C1 RUSH CANC INST,DIV PSYCHOSOCIAL ONCOL,CHICAGO,IL.
RUSH PRESBYTERIAN ST LUKES MED CTR,CHICAGO,IL 60612.
RUSH CANC INST,DEPT PSYCHOL & SOCIAL SCI,CHICAGO,IL.
RP MCCAIN, NL (reprint author), RUSH UNIV,COLL NURSING,DEPT MED NURSING,NATL INST NURSING RES,SSH 301,1743 W HARRISON ST,CHICAGO,IL 60612, USA.
FU NINR NIH HHS [T32 NR07052]
NR 61
TC 29
Z9 29
U1 5
U2 5
PU SAGE PUBL INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320
SN 0193-9459
J9 WESTERN J NURS RES
JI West. J. Nurs. Res.
PD APR
PY 1995
VL 17
IS 2
BP 141
EP 155
DI 10.1177/019394599501700203
PG 15
WC Nursing
SC Nursing
GA RF476
UT WOS:A1995RF47600005
PM 7732682
ER
PT J
AU LEIDY, NK
DARLINGFISHER, CS
AF LEIDY, NK
DARLINGFISHER, CS
TI RELIABILITY AND VALIDITY OF THE MODIFIED ERIKSON PSYCHOSOCIAL STAGE
INVENTORY IN DIVERSE SAMPLES
SO WESTERN JOURNAL OF NURSING RESEARCH
LA English
DT Article
ID SPAN DEVELOPMENTAL-PSYCHOLOGY; CHRONIC PHYSICAL ILLNESS;
PERSONALITY-TRAITS; SOCIAL-ADJUSTMENT; HEMOPHILIC BOYS; SEX-DIFFERENCES;
SELF-REPORT; INTIMACY; GENDER; ADULTHOOD
AB The Modified Erikson Psychosocial Stage Inventory (MEPSI) is a relatively simple survey measure designed to assess the strength of psychosocial attributes that arise from progression through Erikson's eight stages of development. The purpose of this study was to employ secondary analysis to evaluate the internal-consistency reliability and construct validity of the MEPSI across four diverse samples: healthy young adults, hemophilic men, healthy older adults, and older adults with chronic obstructive pulmonary disease. Special attention was given to the performance of the measure across gender, with exploratory analyses examining possible age cohort and health status effects. Internal-consistency estimates for the aggregate measure were high, whereas subscale reliability levels varied across age groups. Construct validity was supported across samples. Gender, cohort, and health effects offered interesting psychometric and theoretical insights and direction for further research. Findings indicated that the MEPSI might be a useful instrument for operationalizing and testing Eriksonian developmental theory in adults.
C1 UNIV MICHIGAN,SCH NURSING,ANN ARBOR,MI 48109.
RP LEIDY, NK (reprint author), NINR,STUDY HUMAN RESPONSES HLTH & ILLNESS LAB,BLDG 31,ROOM 5B25,9000 ROCKVILLE PIKE,BETHESDA,MD 20892, USA.
RI Darling-Fisher, Cynthia/B-5796-2015
OI Darling-Fisher, Cynthia/0000-0002-2145-4875
FU BHP HRSA HHS [F31-NU05685, F31-NU05758]
NR 73
TC 6
Z9 6
U1 2
U2 4
PU SAGE PUBL INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320
SN 0193-9459
J9 WESTERN J NURS RES
JI West. J. Nurs. Res.
PD APR
PY 1995
VL 17
IS 2
BP 168
EP 187
DI 10.1177/019394599501700205
PG 20
WC Nursing
SC Nursing
GA RF476
UT WOS:A1995RF47600007
PM 7732684
ER
PT J
AU EILS, R
SARACOGLU, K
MUNKEL, C
IMHOFF, J
SATZLER, K
BERTIN, E
DIETZEL, S
SCHROCK, E
RIED, T
CREMER, T
CREMER, C
AF EILS, R
SARACOGLU, K
MUNKEL, C
IMHOFF, J
SATZLER, K
BERTIN, E
DIETZEL, S
SCHROCK, E
RIED, T
CREMER, T
CREMER, C
TI 3-DIMENSIONAL IMAGING APPROACHES AND MONTE-CARLO SIMULATIONS -
DEVELOPMENT OF TOOLS TO STUDY THE MORPHOLOGY AND DISTRIBUTION OF
CHROMOSOME TERRITORIES AND SUBCHROMOSOMAL TARGETS IN HUMAN CELL-NUCLEI
SO ZOOLOGICAL STUDIES
LA English
DT Article; Proceedings Paper
CT Focus on Microscopy 95 Conference
CY APR 18-20, 1995
CL TAIPEI, TAIWAN
SP ACADEMIA SINICA, ROC, ACADEMIA SINICA, INST ZOOL, NANKANG, LIFE SCI RES PROMOT CTR NSC, ROC, ELECTRON MICROSCOPY SOC CHINA, TAIPEI, ROC, SOC 3 D IMAGING SCI MICROSCOPY, AMSTERDAM, SUNY, AMIL, BUFFALO, NY
C1 UNIV HEIDELBERG,INST PHYS APPL,D-69115 HEIDELBERG,GERMANY.
UNIV HEIDELBERG,INST THEORET PHYS,D-69115 HEIDELBERG,GERMANY.
UNIV GRENOBLE 1,EQUIPE DYOGEN & LAB TIMC,CNRS,URA 1618,GRENOBLE,FRANCE.
UNIV HEIDELBERG,INST HUMAN GENET & ANTHROPOL,D-69120 HEIDELBERG,GERMANY.
NIH,NATL CTR HUMAN GENOME RES,BETHESDA,MD 20892.
RP EILS, R (reprint author), UNIV HEIDELBERG,DISCIPLINARY CTR SCI COMP IWR 1,GRADUIERTENKOLLEG MODELING & SCI COMP MATH & SCI,D-69120 HEIDELBERG,GERMANY.
RI Satzler, Kurt/E-9910-2012; Eils, Roland/B-6121-2009
OI Eils, Roland/0000-0002-0034-4036
NR 6
TC 7
Z9 7
U1 0
U2 2
PU ACAD SINICA INST ZOOLOGY
PI TAIWAN 115
PA EDITORIAL OFFICE TAIPEI, TAIWAN 115, REP OF CHINA
SN 1021-5506
J9 ZOOL STUD
JI Zool. Stud.
PD APR
PY 1995
VL 34
SU 1
BP 7
EP 10
PG 4
WC Zoology
SC Zoology
GA RA786
UT WOS:A1995RA78600003
ER
PT J
AU JUNG, K
KWON, M
LEE, HY
LEE, HW
HONG, S
AF JUNG, K
KWON, M
LEE, HY
LEE, HW
HONG, S
TI PURIFICATION AND CHARACTERIZATION OF PROTEIN METHYLASE-II FROM PORCINE
TESTIS
SO JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY
LA English
DT Article
DE PORCINE TESTIS; PROTEIN METHYLASE II
ID CARBOXYL METHYLTRANSFERASE; SIGNAL TRANSDUCTION; BOVINE BRAIN;
WHEAT-GERM; CARBOXYMETHYLASE; ISOZYMES
AB Protein methylase II (S-adenosyl-L-methionine : protein O-methyl-transferase, EC 2.1.1.24; PM II) was purified approximately 1250-fold from porcine testis by fractional precipitation and DEAE-cellulose chromatography, followed by gel filtration on a Sephadex G-75 column and HPLC on a Protein Pak 125 column. The molecular weight of the enzyme was estimated to be 33,000 daltons by SDS-PAGE, which agreed with the value determined by gel filtration. Isoelectric focusing of purified PM II showed a single protein species with an isoelectric point of 6.2. The optimum pH for the reaction was 6.0. The K-m value of the enzyme was 1X10(-5) M with a V-max value of 769 pmol/min/mg of enzyme. S-adenosyl-L-homosysteine is a competitive inhibitor of PM II with a K-i value of 1.38X10(-6) M.
C1 NCI, PATHOL LAB, BETHESDA, MD 20892 USA.
SUNGKYUNKWAN UNIV, COLL PHARM, BIOCHEM LAB, SUWON 440746, SOUTH KOREA.
SUNGKYUNKWAN UNIV, COLL LIFE SCI & NAT RESOURCES, DEPT GENET ENGN, SUWON 440746, SOUTH KOREA.
NR 30
TC 3
Z9 3
U1 0
U2 0
PU SPRINGER SINGAPORE PTE LTD
PI SINGAPORE
PA #04-01 CENCON I, 1 TANNERY RD, SINGAPORE 347719, SINGAPORE
SN 1225-8687
J9 J BIOCHEM MOL BIOL
JI J. Biochem. Mol. Biol.
PD MAR 31
PY 1995
VL 28
IS 2
BP 149
EP 154
PG 6
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QW387
UT WOS:A1995QW38700011
ER
PT J
AU YU, JC
LI, WQ
WANG, LM
UREN, A
PIERCE, JH
HEIDARAN, MA
AF YU, JC
LI, WQ
WANG, LM
UREN, A
PIERCE, JH
HEIDARAN, MA
TI DIFFERENTIAL REQUIREMENT OF A MOTIF WITHIN THE CARBOXYLTERMINAL DOMAIN
OF ALPHA-PLATELET-DERIVED GROWTH-FACTOR (ALPHA-PDGF) RECEPTOR FOR PDGF
FOCUS-FORMING ACTIVITY CHEMOTAXIS, OR GROWTH
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Note
ID KINASE INSERT DOMAIN; SIGNALING PATHWAYS; PHOSPHOLIPASE-C; EXPRESSION;
SEQUENCE; PROTEIN
AB To determine the molecular basis for the transforming function of platelet derived growth factor (PDGF)-A in NIH/3T3 cells, we have constructed chimerae consisting of the extracellular domain of the human CSF-1R (fms) linked to the cytoplasmic domain of the alpha PDGF receptor (alpha R) containing a series of deletion or point mutations. The ability of fms/alpha R chimerae to mediate CSF-l-dependent anchorage-independent growth, focus formation, and chemotaxis of NIH/3T3 cells was then examined. Our results provide evidence that a domain encompassing amino acid residues 977-1024 of the alpha PDGFR is required for ligand-dependent focus formation, but not chemotaxis or anchorage-independent growth, and that tyrosine residues within this domain constitute the major binding site for phospholipase C gamma. Therefore, our findings suggest that: (i) the focus forming function of alpha PDGFR correlates well with the ability of the receptor to bind phospholipase C gamma, and (ii) the mechanism of focus formation mediated by (alpha PDGFR may be distinguished from that required for chemotaxis or anchorage-independent growth.
C1 NCI,CELLULAR & MOLEC BIOL LAB,BETHESDA,MD 20892.
NR 23
TC 22
Z9 22
U1 0
U2 2
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 31
PY 1995
VL 270
IS 13
BP 7033
EP 7036
PG 4
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QQ431
UT WOS:A1995QQ43100006
PM 7706238
ER
PT J
AU GHOSH, M
HOWARD, KJ
CAMERON, CE
BENKOVIC, SJ
HUGHES, SH
LEGRICE, SFJ
AF GHOSH, M
HOWARD, KJ
CAMERON, CE
BENKOVIC, SJ
HUGHES, SH
LEGRICE, SFJ
TI TRUNCATING ALPHA-HELIX E' OF P66 HUMAN-IMMUNODEFICIENCY-VIRUS
REVERSE-TRANSCRIPTASE MODULATES RNASE-H FUNCTION AND IMPAIRS DNA STRAND
TRANSFER
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID HIV-1 RIBONUCLEASE-H; AMINO-ACID-RESIDUES; ESCHERICHIA-COLI;
CRYSTAL-STRUCTURE; ANGSTROM RESOLUTION; MUTATIONAL ANALYSIS; DOMAIN;
POLYMERASE; MUTAGENESIS; INHIBITOR
AB The properties of recombinant p66/p51 human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) containing C-terminal truncations in its p66 polypeptide were evaluated, Deletion end points partly or completely removed alpha-helix E' of the RNase H domain (p66 Delta 8/p51 and p66 Delta 16/p51, respectively), while mutant p66 Delta 23/p51 lacked alpha E' and the beta 5'-alpha E' connecting loop. Although dimerization and DNA polymerase properties of all mutants were not significantly different from those of the parental enzyme, p66 Delta 16/p51 and p66 Delta 23/p51 RT lacked ribonuclease H (RNase H) activity, In contrast, RT mutant p66 Delta 8/p51 retained endonuclease activity but lacked the directional processing feature of the parental enzyme, Despite retaining full endoribonuclease function, p66 Delta 8/p51 RT barely supported transfer of nascent (-)-strand DNA between RNA templates representing the 5' and 3' ends of retroviral genome, shedding light on the requirement for the endonuclease and directional processing functions of the RNase H domain during replication.
C1 CASE WESTERN RESERVE UNIV,SCH MED,DIV INFECT DIS,CLEVELAND,OH 44106.
PENN STATE UNIV,DEPT CHEM,UNIVERSITY PK,PA 16802.
NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,FREDERICK,MD 21702.
FU NCI NIH HHS [N01-CO-74101]; NIGMS NIH HHS [GM46623, GM13306]
NR 47
TC 48
Z9 48
U1 0
U2 1
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 31
PY 1995
VL 270
IS 13
BP 7068
EP 7076
PG 9
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QQ431
UT WOS:A1995QQ43100013
PM 7535765
ER
PT J
AU SCHULTZCHERRY, S
CHEN, H
MOSHER, DF
MISENHEIMER, TM
KRUTZSCH, HC
ROBERTS, DD
MURPHYULLRICH, JE
AF SCHULTZCHERRY, S
CHEN, H
MOSHER, DF
MISENHEIMER, TM
KRUTZSCH, HC
ROBERTS, DD
MURPHYULLRICH, JE
TI REGULATION OF TRANSFORMING GROWTH-FACTOR-BETA ACTIVATION BY DISCRETE
SEQUENCES OF THROMBOSPONDIN-1
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID HEPARIN-BINDING PEPTIDES; MELANOMA CELL-ADHESION; I REPEATS;
CALCINEURIN-A; IDENTIFICATION; FIBRONECTIN; PHYSIOLOGY; EXPRESSION;
PROPERDIN; PROTEINS
AB Transforming growth factor-beta (TGF-beta) is a potent growth regulatory protein secreted by virtually all cells in a latent form. A major mechanism of regulating TGF-beta activity occurs through factors that central the process ing of the latent to the biologically active form of the molecule. We have shown previously that thrombospondin 1 (TSP1), a platelet alpha-granule and extracellular matrix protein, activates latent TGF-beta via a protease and cell-independent mechanism and have localized the TGF-beta binding/activation region to the type 1 repeats of platelet TSP1. We now report that recombinant human TSP1, but not recombinant mouse TSP2, activates latent TGF-beta. Activation was further localized to the unique sequence RFK found between the first and the second type 1 repeats of TSP1 (amino acids 412-415) by the use of synthetic peptides. A peptide with the corresponding sequence in TSP2, RLR, was inactive. In addition, a hexapeptide GGWSHW, based on a sequence present in the type 1 repeats of both TSP1 and TSP2, inhibited the activation of latent TGF-beta by TSP1. This peptide bound to I-125-active TGF-beta and inhibited interactions of TSP1 with latent TGF-beta. TSP2 also inhibited activation of latent TGF-beta by TSP1, presumably by competitively binding to TGF-beta through the WSHW sequence. These studies show that activation of latent TGF-beta is mediated by two sequences present in the type 1 repeats of TSP1, a sequence (GGWSHW) that binds active TGF-beta and potentially orients the TSP molecule and a second sequence (RFK) that activates latent TGF-beta. Peptides based on these sites have potential therapeutic applications for modulation of TGF-beta activation.
C1 UNIV ALABAMA,DEPT PATHOL,DIV MOLEC & CELLULAR PATHOL,BIRMINGHAM,AL 35294.
UNIV WISCONSIN,DEPT BIOMOLEC CHEM,MADISON,WI 53706.
UNIV WISCONSIN,DEPT MED,MADISON,WI 53706.
NCI,PATHOL LAB,BETHESDA,MD 20892.
RI Roberts, David/A-9699-2008
OI Roberts, David/0000-0002-2481-2981
FU NHLBI NIH HHS [HL08640, HL49111, HL50061, R01 HL050061]
NR 36
TC 292
Z9 299
U1 0
U2 2
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 31
PY 1995
VL 270
IS 13
BP 7304
EP 7310
PG 7
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QQ431
UT WOS:A1995QQ43100044
PM 7706271
ER
PT J
AU FIERER, DS
CHALLBERG, MD
AF FIERER, DS
CHALLBERG, MD
TI THE STOICHIOMETRY OF BINDING OF THE HERPES-SIMPLEX VIRUS TYPE-1
ORIGIN-BINDING PROTEIN, UL9, TO ORI(S)
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID VIRAL-DNA REPLICATION; ESCHERICHIA-COLI; GEL RETARDATION; LAC PROMOTER;
DOMAIN; ORIS; SEQUENCE; HELICASE; GENE; PURIFICATION
AB A number of studies have demonstrated that the herpes simplex virus type 1 (HSV-1) UL9 protein, which is a homodimer in solution, binds to two high affinity binding sites in each origin of replication. Interaction between the proteins bound at the two sites leads to the formation of a complex nucleoprotein structure. The simplest models for this binding interaction predict two possible binding stoichiometries: 1) one UL9 dimer is bound at each site; or 2) one UL9 monomer is bound at each site so that one UL9 dimer occupies both sites, Two recent papers have addressed this issue by using indirect methods to measure the binding stoichiometry, Martin et al. (Martin, D. W., Munoz, R. M., Oliver, D., Subler, M. A., and Deb, S. (1994) Virology 198, 71-80) reported that a monomer of UL9 binds to a single high affinity site, and Stabell and Olive (Stabell, E. C., and Olive, P. D. (1993) Nucleic Acids Res. 21, 5203-5211) concluded that a dimer of UL9 binds to a single high affinity site. We have directly measured the stoichiometry of binding of the carboxyl terminal DNA binding domain of UL9 (t-UL9) to the origin of replication using a double-label gel shift assay. Using a short synthetic double-stranded oligonucleotide containing a single UL9 binding site, one protein-DNA complex was detected in the gel shift assay, and the molar ratio of UL9 DNA binding domains to DNA binding sites in this complex was determined to be 2.0 +/- 0.1 (n = 13). Using the minimal origin sequence excised from plasmid DNA, two protein-DNA complexes were detected, The binding stoichiometry of the faster migrating complex was 1.8 +/- 0.1 (n = 15), and the stoichiometry of the more slowly migrating band was 3.7 +/- 0.4 (n = 15), The simplest explanation for these data is that UL9 binds to the origin of replication as a homodimer with one dimer bound at both high affinity sites.
C1 NIAID,VIRAL DIS LAB,BETHESDA,MD 20892.
NR 40
TC 20
Z9 20
U1 0
U2 0
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 31
PY 1995
VL 270
IS 13
BP 7330
EP 7334
PG 5
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QQ431
UT WOS:A1995QQ43100047
PM 7706274
ER
PT J
AU BROWN, JA
BHARATHI, A
GHOSH, A
WHALEN, W
FITZGERALD, E
DHAR, R
AF BROWN, JA
BHARATHI, A
GHOSH, A
WHALEN, W
FITZGERALD, E
DHAR, R
TI A MUTATION IN THE SCHIZOSACCHAROMYCES-POMBE RAE1 GENE CAUSES DEFECTS IN
POLY(A)(+) RNA EXPORT AND IN THE CYTOSKELETON
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID MESSENGER-RNA; FISSION YEAST; SACCHAROMYCES-CEREVISIAE; CHROMOSOME
CONDENSATION; MICROTUBULE FUNCTION; BETA-SUBUNITS; PROTEIN; TRANSPORT;
MUTANT; INITIATION
AB A collection of fission yeast Schizosaccharomyces pombe conditional mutants was screened for defective nucleocytoplasmic transport of poly(A)(+) RNA by fluorescence in situ hybridization, We identified a temperature-sensitive mutant that accumulated poly(A)(+) RNA in the nucleus and have named it rae1-1, for ribonucleic acid export. All rae1-1 cells exhibit the defect in poly(A)(+) RNA export within 30 min following a shift to the nonpermissive temperature, In addition, in the rae1-1 mutant, actin and tubulin become disorganized, and cells undergo an irreversible cycle arrest, Results from experiments in which rae1-1 cells were arrested in various phases of the cell division cycle and then shifted to nonpermissive temperature suggest that cells are particularly vulnerable to loss of rae1 function during G(2)/M. However, the inability to export RNA from the nucleus to the cytoplasm was not limited to a particular phase of the cell division cycle, The rae1 gene was isolated by complementation and encodes a predicted protein of 352 amino acids with four beta-transducin/WD40 repeats.
C1 NCI, MOLEC VIROL LAB, BETHESDA, MD 20892 USA.
NCI, SURG BRANCH, BETHESDA, MD 20892 USA.
NR 42
TC 113
Z9 116
U1 1
U2 1
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0021-9258
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 31
PY 1995
VL 270
IS 13
BP 7411
EP 7419
PG 9
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QQ431
UT WOS:A1995QQ43100060
PM 7706287
ER
PT J
AU TSAIMORRIS, CH
GENG, Y
BUCZKO, E
DUFAU, ML
AF TSAIMORRIS, CH
GENG, Y
BUCZKO, E
DUFAU, ML
TI CHARACTERIZATION OF DIVERSE FUNCTIONAL ELEMENTS IN THE UPSTREAM SP1
DOMAIN OF THE RAT LUTEINIZING-HORMONE RECEPTOR GENE PROMOTER
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID TRANSCRIPTION; DNA; BOX; RECOGNITION; ACTIVATION; SEQUENCE; PROTEINS;
CLONING; BINDS; SITES
AB Transcription of the luteinizing hormone receptor gene is dependent on Sp1-induced promoter activation from two Sp1 binding domains (Sp1(2) and Sp1(4)) within the 173-base pair promoter. Of the two Sp1 binding domains, the canonical GC box (GGGCGG) was determined by mutation to be the binding element for only the Sp1(2) domain. The Sp1 binding element within the Sp1(4) domain was identified by mutation and immunological/competition studies as the 5'-GGG GTG GGG that conforms to a Zif-268 like three zinc finger binding domain, rather than the canonical 3' Sp1(4) GC box (GGGCGG). The guanines in the third trinucleotide (GGG GTG GGG) were not required for Sp1 binding, although they increased binding affinity, Non-Sp1 protein(s) bind the 3' Sp1(4), GC box, and by themselves exhibit transcriptional activity, Tissue specific differences were localized to this non-Sp1 binding domain, which functionally substituted for the downstream activating M1 regulatory domain in non expressing but not in expressing cells, Mutations of both non-Sp1 and M1 domains were required for inhibition of promoter activity in constructs that retained the Sp1 binding elements in non expressing cells, indicating that together these domains may play a role in regulation of luteinizing hormone receptor gene expression.
C1 NICHHD,ENDOCRINOL & REPROD RES BRANCH,MOLEC ENDOCRINOL SECT,BETHESDA,MD 20892.
NR 27
TC 26
Z9 26
U1 1
U2 1
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 31
PY 1995
VL 270
IS 13
BP 7487
EP 7494
PG 8
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QQ431
UT WOS:A1995QQ43100070
PM 7706295
ER
PT J
AU GENTRYWEEKS, CR
SPOKES, J
THOMPSON, J
AF GENTRYWEEKS, CR
SPOKES, J
THOMPSON, J
TI BETA-CYSTATHIONASE FROM BORDETELLA-AVIUM - ROLE(S) OF LYSINE-214 AND
CYSTEINE RESIDUES IN ACTIVITY AND CYTOTOXICITY
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID ALANINE-SCANNING MUTAGENESIS; PYRIDOXAL-PHOSPHATE; BINDING-SITE;
TRYPTOPHAN SYNTHASE; ESCHERICHIA-COLI; SULFANE SULFUR; SUBSTITUTION;
POLYMERASE; SUBUNIT; GENES
AB beta-Cystathionase (EC 4.4.1.8) from Bordetella avium is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catalyzes the hydrolysis of L-cystine to yield pyruvic acid, NH3, and thiocysteine. The latter compound is highly toxic toward MC3T3-E1 osteogenic cells, rat os teosarcoma cells, and other cell lines maintained in tissue culture (Gentry-Weeks, C. R., Keith, J. M., and Thompson, J. (1993) J. Biol. Chem. 268, 7298-7314). Site directed mutagenesis has established that lysine 214 of the sequence TKYVGGHSD, is primarily responsible for internal aldimine binding of PLP in the holoenzyme. Translation of the DNA sequence of the beta-cystathionase gene (metC) from B. avium, reveals 4 cysteine residues/enzyme subunit (M(r) = 42,600), and spectrophotometric analysis with 4,4' dithiodipyridine showed that there were no disulfide linkages in the native protein. beta-Cystathionase is inhibited by sulfhydryl-reactive agents, including N-ethyhmaleimide (NEM). To elucidate the mechanism of NEM inhibition, each of the 4 cysteine residues at positions 88, 117, 279, and 309 was individually replaced by alanine or glycine. The mutant proteins C88A, C117G, C279G, and C309A were purified to homogeneity, and each was assayed for enzyme activity, PLP-binding, NEM sensitivity, and susceptibility to chymotrypsin digestion. The activities of mutant proteins C88A and C279G were comparable with that of the native enzyme, and since both forms were inhibited by NEM, neither cysteine 88 nor 279 are prerequisite for enzyme activity. By elimination, cysteine residues 117 and 309 must be the targets for alkylation, and resultant inactivation of beta-cystathionase, by the -SH reactive agent. Substitution of cysteine 117 and 309 with glycine and alanine, respectively, yielded the inactive proteins C117G and C309A. PLP was not detectable in these proteins, and their absorption spectra lacked the peak (at 420 nm) that is characteristic of internal PLP-Schiff base formation. Edman degradation revealed that C117G (M(r) similar to 36,000) also lacked the first 63 amino acids comprising the N terminus of the native protein. The beta-cystathionase mutants C117G and C309A showed enhanced susceptibility to chymotrypsin digestion. Cysteine residues 117 and 309 may reside in conformationally sensitive environments, and in the native enzyme these amino acids most probably serve a structural function. Toxicity assays performed with the various mutant proteins obtained by site-directed mutagenesis established that only catalytically active forms of beta-cystathionase were cytotoxic for tissue culture cells.
RP GENTRYWEEKS, CR (reprint author), NIDR,MICROBIAL ECOL LAB,BLDG 30,RM 532,30 CONVENT DR,MSC 4350,BETHESDA,MD 20892, USA.
NR 31
TC 9
Z9 9
U1 0
U2 7
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 31
PY 1995
VL 270
IS 13
BP 7695
EP 7702
PG 8
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QQ431
UT WOS:A1995QQ43100096
PM 7706318
ER
PT J
AU BAI, G
KUSIAK, JW
AF BAI, G
KUSIAK, JW
TI FUNCTIONAL-ANALYSIS OF THE PROXIMAL 5'-FLANKING REGION OF THE
N-METHYL-D-ASPARTATE RECEPTOR SUBUNIT GENE, NMDAR1
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID TRANSCRIPTION FACTOR; MESSENGER-RNA; BINDING PROTEIN; NERVOUS-SYSTEM;
GABA-A; PROMOTER; RAT; EXPRESSION; CELLS; CLONING
AB The NMDAR1 receptor subunit is a common subunit of N-methyl-D-aspartate receptors. We have previously characterized 3 kilobases (kb) of 5'-flanking sequence of the NMDAR1 gene and now report on the ability of this region to direct transcription of a reporter gene and on its interaction with nuclear proteins, The sequence 356 base pairs (bp) 5' of the first nucleotide of codon 1 was sufficient to express a luciferase reporter gene in rat PC12 pheochromocytoma cells, Additional sequences upstream of nucleotide -356 influenced the activity approximately 2-fold. A labeled 112-bp fragment (position -356 to -245) formed six complexes (C1A and -B, C2A and -B, and C3A and -B), grouped as three double bands, with nuclear extracts from PC12 cells, Competition with Sp1 oligonucleotides abolished formation of C2A and -B and C3A and -B complexes. Sp1 antibody recognized the C3A complex in supershift experiments, Prior immunoprecipitation of nuclear extracts with Spl antibody abolished formation of C2A and -B and C3A and -B complexes. Purified Sp1 protein alone did not form a C3A complex but potentiated its formation when PC12 nuclear extract was added, A CC-rich sequence in this fragment was protected from DNase I digestion by nuclear extract, These results suggest that a 356-bp sequence comprises the NMDAR1 basal promoter, and that NMDAR1 gene expression may be regulated by Sp1-like nuclear factors.
RP BAI, G (reprint author), NIA,GERONTOL RES CTR,MOLEC NEUROBIOL UNIT,4940 EASTERN AVE,BALTIMORE,MD 21224, USA.
NR 55
TC 72
Z9 73
U1 0
U2 0
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 31
PY 1995
VL 270
IS 13
BP 7737
EP 7744
PG 8
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QQ431
UT WOS:A1995QQ43100102
PM 7706322
ER
PT J
AU SIDDIQI, SM
JACOBSON, KA
ESKER, JL
OLAH, ME
JI, XD
MELMAN, N
TIWARI, KN
SECRIST, JA
SCHNELLER, SW
CRISTALLI, G
STILES, GL
JOHNSON, CR
IJZERMAN, AP
AF SIDDIQI, SM
JACOBSON, KA
ESKER, JL
OLAH, ME
JI, XD
MELMAN, N
TIWARI, KN
SECRIST, JA
SCHNELLER, SW
CRISTALLI, G
STILES, GL
JOHNSON, CR
IJZERMAN, AP
TI SEARCH FOR NEW PURINE-MODIFIED AND RIBOSE-MODIFIED ADENOSINE-ANALOGS AS
SELECTIVE AGONISTS AND ANTAGONISTS AT ADENOSINE RECEPTORS
SO JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Article
ID CARBOCYCLIC ANALOGS; RAT-BRAIN; NUCLEOSIDES; DERIVATIVES; ARISTEROMYCIN;
ENANTIOMERS; RESOLUTION
AB The binding affinities at rat A(1), A(2a), and A(3) adenosine receptors of a wide range of derivatives of adenosine have been determined. Sites of modification include the purine moiety (1-, 3-, and 7-deaza; halo, alkyne, and amino substitutions at the 2- and 8-positions; and N6(-)CH(2)-ring, -hydrazino, and -hydroxylamino) and the ribose moiety (2'-, 3'-, and 5'-deoxy; 2'- and 3'-O-methyl;2'-deoxy 2'-fluoro;6'-thio;5'-uronamide;carbocyclic;4'- or 3'-methyl; and inversion of configuration. (-)- and (+)-5'-Noraristeromycin were 48- and 21-fold selective, respectively, for A(2a), vs A(1) receptors. 2-Chloro-6'-thioadenosine displayed a K-i value of 20 nM at A(2a) receptors (15-fold selective vs A(1)). 2-Chloroadenin-9-yl(beta-L-2'-deoxy-6'-thiolyxofuranoside) displayed a K-i value of 8 mu M at A(1) receptors and appeared to be an antagonist, on the basis of the absence of a GTP-induced shift in binding vs a radiolabeled antagonist (8-cyclopentyl-1,3-dipropylxanthine). 2-Chloro-2'-deoxyadenosine and 2-chloroadenin-9-yl(beta-D-6'-thioarabinoside) were putative partial agonists at A(1) receptors, with K-i values of 7.4 and 5.4 mu M, respectively. The A(2a) selective agonist 2-(1-hexynyl)-5'-(N-ethylcarbamoyl)adenosine displayed a K-i value of 26 nM at A(3) receptors. The 4'-methyl substitution of adenosine was poorly tolerated, yet when combined with other favorable modifications, potency was restored. Thus, N-6-benzyl-4'methyladenosine-5'-(N-methyluronamide) displayed a K-i value of 604 nM at A(3) receptors and was 103- and 88-fold selective vs A(1) and A(2a) receptors, respectively. This compound was a full agonist in the A(3)-mediated inhibition of adenylate cyclase in transfected CHO cells. The carbocyclic analogue of N-6-(3-iodobenzyl)adenosine-5'-(N-methyluronamide) was 2-fold selective for A(3) VS A(1) receptors and was nearly inactive at A(2a) receptors.
C1 NIDDK, LBC, MRS, BETHESDA, MD 20892 USA.
SO RES INST, ORGAN CHEM RES DEPT, BIRMINGHAM, AL 35255 USA.
WAYNE STATE UNIV, DEPT CHEM, DETROIT, MI 48202 USA.
DUKE UNIV, MED CTR, DEPT MED, DURHAM, NC 27710 USA.
UNIV CAMERINO, DIPARTIMENTO SCI CHIM, I-62032 CAMERINO, ITALY.
LEIDEN AMSTERDAM CTR DRUG RES, DIV MED CHEM, 2300 RA LEIDEN, NETHERLANDS.
AUBURN UNIV, DEPT CHEM, AUBURN, AL 36849 USA.
RI Jacobson, Kenneth/A-1530-2009
OI Jacobson, Kenneth/0000-0001-8104-1493
FU Intramural NIH HHS [Z01 DK031117-20, Z99 DK999999]; NIAID NIH HHS
[N01-AI-72645, R01 AI072645]
NR 65
TC 81
Z9 82
U1 0
U2 5
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0022-2623
EI 1520-4804
J9 J MED CHEM
JI J. Med. Chem.
PD MAR 31
PY 1995
VL 38
IS 7
BP 1174
EP 1188
DI 10.1021/jm00007a014
PG 15
WC Chemistry, Medicinal
SC Pharmacology & Pharmacy
GA QQ921
UT WOS:A1995QQ92100014
PM 7707320
ER
PT J
AU FORD, H
SIDDIQUI, MA
DRISCOLL, JS
MARQUEZ, VE
KELLEY, JA
MITSUYA, H
SHIRASAKA, T
AF FORD, H
SIDDIQUI, MA
DRISCOLL, JS
MARQUEZ, VE
KELLEY, JA
MITSUYA, H
SHIRASAKA, T
TI LIPOPHILIC, ACID-STABLE, ADENOSINE DEAMINASE-ACTIVATED ANTI-HIV PRODRUGS
FOR CENTRAL-NERVOUS-SYSTEM DELIVERY .2. 6-HALO AND 6-ALKOXY PRODRUGS OF
2'-BETA-FLUORO-2',3'-DIDEOXYINOSINE
SO JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Article
ID BLOOD-BRAIN-BARRIER; CEREBROSPINAL-FLUID; 2',3'-DIDEOXYPURINE
NUCLEOSIDES; TUBERCULOUS MENINGITIS; CATALYZED HYDROLYSIS; ADENINE
NUCLEOSIDES; HTLV-III; INFECTION; AIDS; 2',3'-DIDEOXYADENOSINE
AB A series of 6-halo-(F-, Cl-, Br-, I-) and 6-alkoxy-(OMe-, OEt-) 9-(2,3-dideoxy-2-fluoro-beta-D-threo-pentofuranosyl) purines (F-ddN) have been synthesized and characterized with the objective of finding compounds which might be superior to existing drugs for the treatment of HIV in the central nervous system. These compounds, which contain lipophilic 6-substituents, were chosen as acid-stable prodrugs for the anti-HIV-active F-ddN, 9-(2,3-dideoxy-2-fluoro-beta-D-threo-pentofuranosyl) hypoxanthine (F-ddI), because of their potential to increase blood-brain-barrier penetration relative to F-ddI. All the new compounds were more lipophilic than the currently approved anti-AIDS drugs. Partition coefficient increases of 30- and 110-fold were achieved, relative to didanosine (ddI), for the 6-chloro- and 6-ethoxy analogues; 2'-Fluoro substitution abolished the pH 1, acid-catalyzed cleavage of the nucleoside glycosylic bond. However, pH 1, acid-catalyzed hydrolysis of the 6-fluoro substituent to produce: F-ddI was observed to occur at a rate (t(1/2) 0.54 h) which was ca. 40-170 times faster than that of the other prodrugs. The utility of the F-dCLNs as prodrugs for F-ddI depends upon their ability to act as substrates for. adenosine deaminase. The relative rates of adenosine deaminase-catalyzed prodrug hydrolysis to F-ddI varied by a factor of >25 000 with the 6-fluoro- and 6-ethoxy analogues reacting the fastest and slowest, respectively. All of the prodrugs possessed anti-HIV activity in the phytohemagglutinin-stimulated peripheral blood mononuclear cell test system and a qualitative correlation exists between prodrug anti-HIV activity and adenosine deaminase hydrolysis rates.
C1 NCI,MED CHEM LAB,DEV THERAPEUT PROGRAM,BETHESDA,MD 20892.
NCI,DIV CANC TREATMENT,CLIN ONCOL PROGRAM,MED BRANCH,EXPTL RETROVIROL SECT,BETHESDA,MD 20892.
NR 53
TC 30
Z9 31
U1 0
U2 0
PU AMER CHEMICAL SOC
PI WASHINGTON
PA PO BOX 57136, WASHINGTON, DC 20037-0136
SN 0022-2623
J9 J MED CHEM
JI J. Med. Chem.
PD MAR 31
PY 1995
VL 38
IS 7
BP 1189
EP 1195
DI 10.1021/jm00007a015
PG 7
WC Chemistry, Medicinal
SC Pharmacology & Pharmacy
GA QQ921
UT WOS:A1995QQ92100015
PM 7707321
ER
PT J
AU MOORE, SA
SIELECKI, AR
CHERNAIA, MM
TARASOVA, NI
JAMES, MNG
AF MOORE, SA
SIELECKI, AR
CHERNAIA, MM
TARASOVA, NI
JAMES, MNG
TI CRYSTAL AND MOLECULAR-STRUCTURES OF HUMAN PROGASTRICSIN AT 1.62 ANGSTROM
RESOLUTION
SO JOURNAL OF MOLECULAR BIOLOGY
LA English
DT Article
DE PROGASTRICSIN; ZYMOGEN; ASPARTIC PROTEINASE; CRYSTALLOGRAPHY
ID AMINO-ACID-SEQUENCE; PEPSINOGEN-C PROGASTRICSIN; MULTIWIRE AREA
DETECTOR; PORCINE PEPSINOGEN; GASTRIC-MUCOSA; MACROMOLECULAR STRUCTURES;
ASPARTIC PROTEINASES; TRANSLATION-FUNCTION; GENE DUPLICATION; 1.8-A
RESOLUTION
AB The crystal and molecular structures of human progastricsin (hPGC) have been determined using multiple isomorphous replacement methods and anomalous scattering in conjunction with a phased translation function. The structure has been refined to a conventional R-factor (=Sigma parallel to F-o\ - \F-c parallel to/Sigma\F-o\) of 0.179 with data to 1.62 Angstrom resolution. The first 37 amino acid residues of the prosegment are similar in conformation to the equivalent residues of porcine pepsinogen (pPGN). As in pPGN, the N-zeta atom of Lys37p sits between the active-site carboxylate groups of Asp32 and Asp217, thereby preventing catalysis. The side-chains of Tyr38p and Tyr9 sit in the S1' and S1 substrate-binding pockets of hPGC, respectively, in an analogous manner to what is observed in porcine pepsinogen. There are large conformational differences centered around the region containing residues Arg39p to Pro6, relative to the equivalent region in the structure of pPGN. Two surface loops in the vicinity of this segment are also displaced relative to those in pPGN and in mature aspartic proteinases (Phe71 to Thr81 (the ''flap''), and Tyr125 to Thr131). In hPGC, Tyr75 O-eta does not make its usual hydrogen bond to Trp39 N-epsilon l. Rather, the ''flap'' containing Tyr75 is excluded from the active site by the polypeptide segment Arg39p to Pro6. However, the conformation of the inhibitory segment, Lys37p to Tyr38p, is virtually identical with that observed in pPGN. Hence the structures of these two proteins indicate that aspartic proteinase zymogens keep themselves inactive at neutral pH by a very similar mechanism in human progastricsin and porcine pepsinogen. This similarity likely carries over to all members of both the pepsinogen A and C families of aspartic proteinase zymogens.
C1 UNIV ALBERTA,DEPT BIOCHEM,CANADA GRP PROT STUCT & FUNCT,MRC,EDMONTON,AB T6G 2H7,CANADA.
RUSSIAN ACAD SCI,VA ENGELHARDT MOLEC BIOL INST,MOSCOW,RUSSIA.
NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,MOLEC ASPECTS DRUG DESIGN SECT,FREDERICK,MD 21702.
FU NCI NIH HHS [N01-CO-74101]
NR 75
TC 53
Z9 56
U1 0
U2 0
PU ACADEMIC PRESS (LONDON) LTD
PI LONDON
PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX
SN 0022-2836
J9 J MOL BIOL
JI J. Mol. Biol.
PD MAR 31
PY 1995
VL 247
IS 3
BP 466
EP 485
DI 10.1006/jmbi.1994.0154
PG 20
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QQ236
UT WOS:A1995QQ23600009
PM 7714902
ER
PT J
AU VARMUS, H
AF VARMUS, H
TI NIH REVIEW OF GENE-THERAPY PROTOCOLS
SO SCIENCE
LA English
DT Letter
RP VARMUS, H (reprint author), NIH,BLDG 10,BETHESDA,MD 20892, USA.
NR 2
TC 4
Z9 4
U1 1
U2 1
PU AMER ASSOC ADVAN SCIENCE
PI WASHINGTON
PA 1333 H ST NW, WASHINGTON, DC 20005
SN 0036-8075
J9 SCIENCE
JI Science
PD MAR 31
PY 1995
VL 267
IS 5206
BP 1889
EP 1889
DI 10.1126/science.7701310
PG 1
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA QQ068
UT WOS:A1995QQ06800002
PM 7701310
ER
PT J
AU ZEROMSKI, J
JEZEWSKA, E
SIKORA, J
KASPRZAK, KS
AF ZEROMSKI, J
JEZEWSKA, E
SIKORA, J
KASPRZAK, KS
TI THE EFFECT OF NICKEL COMPOUNDS ON IMMUNOPHENOTYPE AND
NATURAL-KILLER-CELL FUNCTION OF NORMAL HUMAN-LYMPHOCYTES
SO TOXICOLOGY
LA English
DT Article
DE NICKEL SALTS; NICKEL IMMUNOTOXICITY; HUMAN IMMUNE CELLS;
IMMUNOPHENOTYPE; NATURAL KILLER CELLS
ID MAGNESIUM; IMMUNITY; CHLORIDE
AB In order to elucidate effects of nickel on human lymphocytes in vitro, peripheral blood mononuclear cells from normal donors were initially tested for viability in the presence of increasing concentrations of two selected nickel salts, sparingly-soluble nickel subsulfide (Ni3S2), and promptly-soluble nicker sulfate (NiSO4). After establishing the toxicity profile, the cells were cultured for 24 h with each compound at three nontoxic concentrations, 0.01 mM, 0.02 mM, and 0.04 mM, to determine its effect on lymphocyte immunophenotype and function. Cells were also cultured in the presence of 0.01-0.04 mM magnesium acetate, Mg(CH3COO)(2) while still other cell samples were subjected to a mixture of Mg(CH3COO)(2) plus either Ni3S2 or NiSO4 at equimolar concentration. Following the culture, the immunophenotype of the cells was determined by indirect immunofluorescence, using monoclonal antibodies to major differentiation antigens of peripheral blood mononuclear cells, and their natural killer activity toward K562 target cells was measured. Both nickel salts were found to exert distinct effects on lymphocyte phenotype. Exposure of cells to Ni3S2 resulted in the decline of CD4 and natural killer cell populations. NiSO4 diminished the abundance of natural killer cells and, to a limited extent, also of CD4 cells. The nickel salts tested suppressed natural cytotoxicity of peripheral blood mononuclear cells, with Ni3S2 acting more strongly than NiSO4. The addition of Mg(CH3COO)(2) to a nickel salt during in vitro culture abolished the above inhibitory-effects. Nickel and magnesium salts did not affect CD3, CD8, CD20, and CD11a cell populations. The results indicate that nickel salts have deleterious effects on human peripheral blood mononuclear cells in short-term in vitro culture, but the magnitude of these effects varies, depending on the cell subsets.
C1 NCI,FREDERICK CANC RES & DEV CTR,COMPARAT CARCINOGENESIS LAB,FREDERICK,MD 21702.
POZNAN UNIV,SCH MED,DEPT IMMUNOPATHOL,PL-60355 POZNAN,POLAND.
NR 26
TC 13
Z9 14
U1 0
U2 1
PU ELSEVIER SCI PUBL IRELAND LTD
PI CLARE
PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE,
IRELAND
SN 0300-483X
J9 TOXICOLOGY
JI Toxicology
PD MAR 31
PY 1995
VL 97
IS 1-3
BP 39
EP 48
PG 10
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA QT012
UT WOS:A1995QT01200006
PM 7716791
ER
PT J
AU CLEAVELAND, ES
MONKS, A
VAIGROWOLFF, A
ZAHAREVITZ, DW
PAULL, K
ARDALAN, K
COONEY, DA
FORD, H
AF CLEAVELAND, ES
MONKS, A
VAIGROWOLFF, A
ZAHAREVITZ, DW
PAULL, K
ARDALAN, K
COONEY, DA
FORD, H
TI SITE OF ACTION OF 2 NOVEL PYRIMIDINE BIOSYNTHESIS INHIBITORS ACCURATELY
PREDICTED BY THE COMPARE PROGRAM
SO BIOCHEMICAL PHARMACOLOGY
LA English
DT Article
DE BREQUINAR; BNID; DCL; CYTIDINE; URIDINE; MOLT-4 LYMPHOBLASTS;
CHEMOTHERAPY; ANTIMETABOLITES
ID TUMOR-CELL-LINES; DIHYDROOROTATE DEHYDROGENASE; BREQUINAR SODIUM;
NUCLEOTIDE BIOSYNTHESIS; DENOVO; MECHANISM; CANCER
AB The computer algorithm COMPARE provides information regarding the biological mechanism of action of a compound. In this study, excellent correlations were obtained for 2,2'-[3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)diimino]bis-benzoic acid (redoxal) and 1-(p-bromophenyl)-2-methyl-1H-naphth[2,3-d]imidazole-4,9-dione (BNID) and two well-studied dihydroorotate dehydrogenase (DHOD) inhibitors, dichloroallyl lawsone and brequinar, in terms of antiproliferative activity against tumor cell lines in vitro. When redoxal and BNID were incubated with MOLT-4 cells for 72 hr, 50% growth inhibition was achieved at 0.7 and 3.5 mu M, respectively. After 24 hr of incubation, pyrimidine triphosphate pools were shown to be decreased by 50% by redoxal (1 mu M) and BNID (0.25 mu M) Addition of either uridine (50 mu M) or cytidine (100 mu M) antagonized the cellular cytotoxicity caused by either drug; uridine corrected the UTP and CTP deficit, whereas cytidine corrected only the CTP deficit. Exposure of MOLT-4 cells to a 1 mu M concentration of either drug for 18 hr followed by a 1-hr exposure to [C-14]bicarbonate showed a 97% decrease of incorporation of [C-14] into pyrimidine triphosphates accompanied by a 91- and 82-fold increase in radioactive incorporation into L-dihydroorotate and N-carbamyl-L-aspartate, respectively. By direct exposure of DHOD prepared from MOLT-4 cell mitochondria to a range of concentrations of the two drugs, apparent K-i values of 0.33 mu M (redoxal) and 0.53 mu M (BNID) were determined. These data provide direct evidence for inhibition of DHOD by redoxal and BNID in MOLT-4 lymphoblasts.
C1 NCI,DIV CANC TREATMENT,DEV THERAPEUT PROGRAM,INFORMAT TECHNOL BRANCH,BETHESDA,MD 20892.
NCI,FREDERICK CANC RES & DEV CTR,PRI DYNCORP,FREDERICK,MD 21702.
RP CLEAVELAND, ES (reprint author), NCI,MED CHEM LAB,BLDG 37,ROOM 5B22,9000 ROCKVILLE PIKE,BETHESDA,MD 20892, USA.
NR 14
TC 34
Z9 34
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
SN 0006-2952
J9 BIOCHEM PHARMACOL
JI Biochem. Pharmacol.
PD MAR 30
PY 1995
VL 49
IS 7
BP 947
EP 954
DI 10.1016/0006-2952(95)00009-O
PG 8
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA QR216
UT WOS:A1995QR21600010
PM 7741767
ER
PT J
AU ADAMS, JD
YAGI, H
LEVIN, W
JERINA, DM
AF ADAMS, JD
YAGI, H
LEVIN, W
JERINA, DM
TI STEREOSELECTIVITY AND REGIOSELECTIVITY IN THE METABOLISM OF
7,8-DIHYDROBENZO[A]PYRENE BY CYTOCHROME-P450, EPOXIDE HYDROLASE AND
HEPATIC MICROSOMES FROM 3-METHYLCHOLANTHRENE-TREATED RATS
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article
DE 7,8-DIHYDROBENZO[A]PYRENE; BAY-REGION EPOXIDES; CYTOCHROME P450 1A1;
EPOXIDE HYDROLASE
ID DIOL-EPOXIDES; STEREOSELECTIVE METABOLISM; EXCEPTIONAL ACTIVITY; LIVER
ENZYMES; MUTAGENICITY; BENZOPYRENE; BENZANTHRACENE;
7,8-DIHYDRODIOL; TUMORIGENICITY; CHROMATOGRAPHY
AB The active site of cytochrome P450 1A1 has been probed with the substrate, 7,8-dihydrobenzo[a]pyrene using a purified, reconstituted system composed of cytochrome P450 1A1, NADPH-cytochrome c reductase and lipid in the presence or absence of epoxide hydrolase. The turnover of the substrate was found to be 38 nmol/nmol of cytochrome P450/min. The metabolic products that were identified are: a phenolic 7,8-dihydrobenzo[a]pyrene (20-29%); 9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (17-28%); benzo[a]pyrene (12-19%); 7-hydroxy-7,8-dihydrobenzo[a]pyrene (13-16%); 8-hydroxy-7,8-dihydrobenzo[a]pyrene (7-15%); 3-hydroxybenzo[a]pyrene (7-15%); 4,5-epoxy-4,5,7,8-tetrahydrobenzo[a]pyrene (0-4%); and a triol of 7,8,9,10-tetrahydrobenzo[a]pyrene (0-4%). 9,10-Epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene undergoes rapid hydrolysis to cis- and trans-9,10-dihydroxy-7,8,9,1O-tetrahydrobenzo[a]pyrene (2:1) by benzylic attack of water at C-10. Approximately 71% of the trans diols are derived from (+)-(9S,10R)-9,10-epoxy-7,8,9,1O-tetrahydrobenzo[a]pyrene, indicating that cytochrome P450 1A1 has more than a 2:1 preference for selective epoxidation of an enantiotopic face of 7,8-dihydrobenzo[a]pyrene. This stereo-selectivity agrees with the postulated stereo-selectivity predicted by a previously described active site model for cytochrome P450 1A1. Epoxide hydrolase in pure form or in hepatic microsomes catalyzes the hydrolysis of 9,10-epoxy-7,8,9, 10-tetrahydrobenzo[a]pyrene, which is inhibited by 1,1,1-trichloropropane 2,3-oxide. The (+)-(9S,10R)-isomer of the epoxide is slightly preferred as a substrate over its enantiomer and is cleaved by benzylic and nonbenzylic attack. Only benzylic attack was found with (-)-(9R,10S)-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.
C1 NIDDKD,BIOORGAN CHEM LAB,BETHESDA,MD 20892.
HOFFMANN LA ROCHE INC,DEPT INFLAMMAT AUTO IMMUNE DIS,NUTLEY,NJ 07110.
RP ADAMS, JD (reprint author), UNIV SO CALIF,SCH PHARM,1985 ZONAL AVE,PSC 508,LOS ANGELES,CA 90033, USA.
NR 41
TC 12
Z9 13
U1 0
U2 0
PU ELSEVIER SCI PUBL IRELAND LTD
PI CLARE
PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE,
IRELAND
SN 0009-2797
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD MAR 30
PY 1995
VL 95
IS 1-2
BP 57
EP 77
DI 10.1016/0009-2797(94)03354-4
PG 21
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA QL916
UT WOS:A1995QL91600005
PM 7697754
ER
PT J
AU MTIMAVALYE, L
BIGGAR, RJ
TAHA, TE
CHIPHANGWI, J
AF MTIMAVALYE, L
BIGGAR, RJ
TAHA, TE
CHIPHANGWI, J
TI MATERNAL-INFANT TRANSMISSION OF HIV-1
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Letter
C1 NCI,BETHESDA,MD 20852.
JOHNS HOPKINS UNIV,MINIST HLTH RES PROJECT,BALTIMORE,MD 21218.
UNIV MALAWI,SCH MED,BLANTYRE,MALAWI.
RP MTIMAVALYE, L (reprint author), QUEEN ELIZABETH CENT HOSP,BLANTYRE,MALAWI.
NR 4
TC 6
Z9 6
U1 0
U2 0
PU MASS MEDICAL SOC
PI BOSTON
PA 10 SHATTUCK, BOSTON, MA 02115
SN 0028-4793
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD MAR 30
PY 1995
VL 332
IS 13
BP 890
EP 891
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA QP228
UT WOS:A1995QP22800019
PM 7726969
ER
PT J
AU CONNOR, E
SPERLING, R
GELBER, RD
BALSLEY, J
AF CONNOR, E
SPERLING, R
GELBER, RD
BALSLEY, J
TI MATERNAL-INFANT TRANSMISSION OF HIV-1 - REPLY
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Letter
C1 CUNY MT SINAI SCH MED,NEW YORK,NY 10029.
HARVARD UNIV,SCH PUBL HLTH,BOSTON,MA 02115.
NIAID,BETHESDA,MD 20892.
RP CONNOR, E (reprint author), MEDIMMUNE INC,GAITHERSBURG,MD 20878, USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU MASS MEDICAL SOC
PI BOSTON
PA 10 SHATTUCK, BOSTON, MA 02115
SN 0028-4793
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD MAR 30
PY 1995
VL 332
IS 13
BP 891
EP 891
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA QP228
UT WOS:A1995QP22800020
ER
PT J
AU STRICKLER, HD
RATTRAY, C
ESCOFFERY, C
MANNS, A
SCHIFFMAN, MH
BROWN, C
CRANSTON, B
HANCHARD, B
PALEFSKY, JM
BLATTNER, WA
AF STRICKLER, HD
RATTRAY, C
ESCOFFERY, C
MANNS, A
SCHIFFMAN, MH
BROWN, C
CRANSTON, B
HANCHARD, B
PALEFSKY, JM
BLATTNER, WA
TI HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-I AND SEVERE NEOPLASIA OF THE
CERVIX IN JAMAICA
SO INTERNATIONAL JOURNAL OF CANCER
LA English
DT Article
ID HUMAN PAPILLOMAVIRUS INFECTION; CANCER
AB Human T-cell lymphotropic virus type I (HTLV-I) was associated with carcinoma of the cervix in Japan in a recent study that compared hospital cases with healthy population-based controls. To test this relationship in women more alike for cervical neoplasia risk factors (including sexual behavior and human papilloma virus; HPV), we enrolled consecutive patients from a colposcopy clinic in Kingston, Jamaica (an HTLV-I endemic area). Patients underwent Pap smear, colposcopy, biopsy and cervical swab for detection of HPV by polymerase chain reaction. Cases were defined as women with CIN-3 or invasive cancer (CIN-3/CA). Controls included all patients with either CIN-I or koilocytotic atypia, atypical squamous cells of undetermined significance or benign cervical pathology (all but one had at least inflammatory changes). Patients with CIN-2 were excluded to minimize risk of case-control misclassification. Cases were much more likely to be HTLV-I seropositive than controls. Although mean age differed significantly between cases (mean age 39 years) and controls (mean age = 33 years), control for age did not explain the relation of CIN-3/CA with HTLV-I. Among HPV DNA positive subjects the age-adjusted association was not diminished but lost statistical significance. HTLV-I seroprevalence may be independently associated with progression to severe neoplasia of the cervix. (C) 1995 Wiley-Liss, Inc*
C1 NATL CANC INST,ENVIRONM EPIDEMIOL BRANCH,ROCKVILLE,MD 20852.
UNIV W INDIES,DEPT PATHOL,KINGSTON 7,JAMAICA.
UNIV W INDIES,DEPT GYNECOL,KINGSTON 7,JAMAICA.
UNIV CALIF SAN FRANCISCO,DEPT LAB MED,SAN FRANCISCO,CA 94143.
RP STRICKLER, HD (reprint author), NATL CANC INST,VIRAL BRANCH,6130 EXECUT BLVD,EPN 434,ROCKVILLE,MD 20852, USA.
NR 22
TC 21
Z9 21
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0020-7136
J9 INT J CANCER
JI Int. J. Cancer
PD MAR 29
PY 1995
VL 61
IS 1
BP 23
EP 26
DI 10.1002/ijc.2910610105
PG 4
WC Oncology
SC Oncology
GA QQ317
UT WOS:A1995QQ31700004
PM 7705929
ER
PT J
AU CARDINALI, M
PIETRASZKIEWICZ, H
ENSLEY, JF
ROBBINS, KC
AF CARDINALI, M
PIETRASZKIEWICZ, H
ENSLEY, JF
ROBBINS, KC
TI TYROSINE PHOSPHORYLATION AS A MARKER FOR ABERRANTLY REGULATED
GROWTH-PROMOTING PATHWAYS IN CELL-LINES DERIVED FROM HEAD AND NECK
MALIGNANCIES
SO INTERNATIONAL JOURNAL OF CANCER
LA English
DT Article
ID FACTOR RECEPTOR GENE; FACTOR-ALPHA; AMPLIFICATION; EXPRESSION; KINASES;
TRANSFORMATION; CARCINOMAS; ONCOGENE; CANCER
AB We have utilized a broad approach to address whether tyrosine kinases and the growth pathways they regulate might be functionally aberrant in squamous cell carcinomas (SCC) of the upper aerodigestive tract. This strategy involved assaying for evidence of tyrosine kinase action in lysates of cell lines representing SCC. Our findings revealed a spectrum of elevated tyrosine phosphorylation in SCC lines ranging from less than 2-fold to more than 10-fold above that of control human epidermal keratinocytes. Thus the ability to regulate growth and other pathways controlled by tyrosine phosphorylation was impaired in all the 19 lines examined. Assessment of the receptor for epidermal growth factor (EGF) revealed that its activity was elevated above normal in 14 of the 19 cell lines examined, suggesting that at least a portion of the increased tyrosine phosphorylation observed could be attributed to excessive EGF receptor activity. Our findings provide functional evidence that growth pathways are aberrantly regulated in cell lines representing SCC of the upper aerodigestive tract. (C) 1995 Wiley-Liss, Inc.*
C1 NIDR,CELLULAR DEV & ONCOL LAB,BETHESDA,MD 20892.
WAYNE STATE UNIV,HARPER HOSP,DEPT INTERNAL MED,DIV HEMATOL & ONCOL,DETROIT,MI 48201.
NR 25
TC 86
Z9 86
U1 0
U2 3
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0020-7136
J9 INT J CANCER
JI Int. J. Cancer
PD MAR 29
PY 1995
VL 61
IS 1
BP 98
EP 103
DI 10.1002/ijc.2910610117
PG 6
WC Oncology
SC Oncology
GA QQ317
UT WOS:A1995QQ31700016
PM 7705939
ER
PT J
AU BUBB, MR
KORN, ED
AF BUBB, MR
KORN, ED
TI KINETIC-MODEL FOR THE INHIBITION OF ACTIN POLYMERIZATION BY ACTOBINDIN
SO BIOCHEMISTRY
LA English
DT Article
ID ACANTHAMOEBA ACTOBINDIN; F-ACTIN; BINDING
AB Although Acanthamoeba actobindin binds actin monomers, its inhibition of actin polymerization differs from that of a simple monomer-sequestering protein in that actobindin inhibits nucleation very much more than elongation [Lambooy, P. K., and Korn, E. D. (1988) J. Biol, Chem. 263, 12836-12843] and can induce the accumulation of actin dimers in stoichiometric excess of the actobindin concentration [Bubb, M. R., Knutson, J. R., Porter, D. M,, and Kern, E. D. (1994) J. Biol. Chem, 269, 25592-25597]. We now describe a ''catalytic'' model for the interaction of actobindin with actin monomer that quantitatively accounts for the effects of actobindin on the kinetics of actin polymerization de novo and the elongation of actin filaments. We propose that, in a polymerizing buffer, actobindin binds to two actin subunits forming an heterotrimeric complex that is incompetent for nucleation, self-association, and elongation. Actobindin can, however, dissociate from this complex, leaving a novel actin dimer that can participate in elongation but remains incompetent for nucleation and self-association. Under appropriate conditions, the concentration of this novel actin dimer can exceed the actobindin concentration; thus, the model is catalytic rather than stoichiometric. The experimentally observed time course of actin polymerization de novo, the rate of elongation of filaments, and the amount of actin dimer formed as a function of actobindin concentration are all consistent with the catalytic model and inconsistent with the stoichiometric model. The rate of actobindin-induced actin dimer formation is consistent with the hypothesis that the rate-limiting step is this pathway is the formation of a precursor heterotrimeric complex.
C1 NHLBI, CELL BIOL LAB, BETHESDA, MD 20892 USA.
RI Korn, Edward/F-9929-2012
NR 14
TC 12
Z9 12
U1 1
U2 1
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0006-2960
J9 BIOCHEMISTRY-US
JI Biochemistry
PD MAR 28
PY 1995
VL 34
IS 12
BP 3921
EP 3926
DI 10.1021/bi00012a008
PG 6
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QP971
UT WOS:A1995QP97100008
PM 7696256
ER
PT J
AU GROVER, S
RIMOLDI, JM
MOLINERO, AA
CHAUDHARY, AG
KINGSTON, DGI
HAMEL, E
AF GROVER, S
RIMOLDI, JM
MOLINERO, AA
CHAUDHARY, AG
KINGSTON, DGI
HAMEL, E
TI DIFFERENTIAL-EFFECTS OF PACLITAXEL (TAXOL) ANALOGS MODIFIED AT POSITIONS
C-2, C-7, AND C-3' ON TUBULIN POLYMERIZATION AND POLYMER STABILIZATION -
IDENTIFICATION OF A HYPERACTIVE PACLITAXEL DERIVATIVE
SO BIOCHEMISTRY
LA English
DT Article
ID MICROTUBULE-ASSOCIATED PROTEINS; BIOLOGICAL EVALUATION; ASSEMBLY
INVITRO; TAXOTERE(R); PRECURSOR; TAXANES; BINDS; NMR
AB Our finding that an analog of paclitaxel (Taxol) modified at position C-2 (2-debenzoyl-2-(m-azidobenzoyl)paclitaxel) was substantially more active than paclitaxel in promoting tubulin assembly [Chaudhary et al. (1994) J. Am. Chem. Sec. 116, 4097-4098] led us to perform an analysis of the modulating effects of microtubule-associated proteins, GTP, and temperature on assembly and polymer stability. The analog always showed superior activity to paclitaxel in inducing polymerization where it fails to occur without drug: probably indicating a greater ability than paclitaxel to ''hypernucleate'' assembly. In contrast, much smaller differences in effects on polymer stability were observed. The analysis was extended to a large series of derivatives modified at positions C-2, C-7, C-10, and C-3', including docetaxel, a clinically important analog of paclitaxel. While analog stabilization of polymer was frequently observed, neither qualitative nor quantitative analysis of this property reliably predicted whether a compound would have enhanced hypernucleation activity relative to that of paclitaxel. Stabilization was often observed at substoichiometric analog concentrations, while even superstoichiometric concentrations of most compounds failed to induce extensive tubulin polymerization at low temperatures or in the absence of microtubule-associated proteins or GTP. Docetaxel was intermediate in activity between paclitaxel and 2-debenzoyl-2-(m-azidobenzoyl)paclitaxel in promoting assembly reactions, We conclude that the hypernucleation of tubulin assembly and polymer stabilization observed with paclitaxel represent two distinct properties of the drug. Our findings suggest that paclitaxel, docetaxel, and 2-debenzoyl-2-(m-azidobenzoyl)paclitaxel are able to interact with progressively smaller assemblages of tubulin at low temperatures or in the absence of microtubule-associated proteins or GTP.
C1 NCI,DIV CANC TREATMENT,DEV THERAPEUT PROGRAM,MOLEC PHARMACOL LAB,BETHESDA,MD 20892.
VIRGINIA POLYTECH INST & STATE UNIV,DEPT CHEM,BLACKSBURG,VA 24061.
OI Kingston, David/0000-0001-8944-246X
FU NCI NIH HHS [CA-48974, CA-55131]
NR 40
TC 37
Z9 37
U1 0
U2 3
PU AMER CHEMICAL SOC
PI WASHINGTON
PA PO BOX 57136, WASHINGTON, DC 20037-0136
SN 0006-2960
J9 BIOCHEMISTRY-US
JI Biochemistry
PD MAR 28
PY 1995
VL 34
IS 12
BP 3927
EP 3934
DI 10.1021/bi00012a009
PG 8
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QP971
UT WOS:A1995QP97100009
PM 7696257
ER
PT J
AU AOKI, I
KINZER, C
SHIRAI, A
PAUL, WE
KLINMAN, DM
AF AOKI, I
KINZER, C
SHIRAI, A
PAUL, WE
KLINMAN, DM
TI IGE - RECEPTOR-POSITIVE NON-B/NON-T CELLS DOMINATE THE PRODUCTION OF
INTERLEUKIN-4 AND INTERLEUKIN-6 IN IMMUNIZED MICE
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
ID SPLENIC NON-B; INTERFERON-GAMMA; FC-EPSILON; MURINE LEISHMANIASIS;
STIMULATING FACTOR; CROSS-LINKAGE; IL-4; LYMPHOKINES; EXPRESSION;
BASOPHILS
AB The phenotype and antigenic specificity of cells secreting interleukin (IL) 4, IL-6, and interferon gamma was studied in mice during primary and secondary immune responses. T lymphocytes were the major source of interferon gamma, whereas non-B/non-T cells were the dominant source of IL-4 and IL-6 in the spleens of immunized animals. Cytokine-secreting non-B/non-T cells expressed surface receptors for IgE and/or IgG types II/III. Exposing these cells to antigen-specific IgE or IgG in vivo (or in vitro) ''armed'' them to release IL-4 and IL-6 upon subsequent antigenic challenge. These findings suggest that non-B/non-T cells may represent the ''natural immunity'' analogue of CD4(+) T helper type 2 cells and participate in a positive feedback loop involved in the perpetuation of T helper type 2 cell responses.
C1 NIAID,IMMUNOL LAB,BETHESDA,MD 20892.
RP AOKI, I (reprint author), US FDA,CTR BIOL EVALUAT & RES,DIV VIRAL PROD,RETROVIRAL IMMUNOL SECT,BETHESDA,MD 20892, USA.
NR 39
TC 37
Z9 37
U1 0
U2 0
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAR 28
PY 1995
VL 92
IS 7
BP 2534
EP 2538
DI 10.1073/pnas.92.7.2534
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA QP889
UT WOS:A1995QP88900026
PM 7708680
ER
PT J
AU SANDERSON, N
FACTOR, V
NAGY, P
KOPP, J
KONDAIAH, P
WAKEFIELD, L
ROBERTS, AB
SPORN, MB
THORGEIRSSON, SS
AF SANDERSON, N
FACTOR, V
NAGY, P
KOPP, J
KONDAIAH, P
WAKEFIELD, L
ROBERTS, AB
SPORN, MB
THORGEIRSSON, SS
TI HEPATIC EXPRESSION OF MATURE TRANSFORMING GROWTH-FACTOR-BETA-1 IN
TRANSGENIC MICE RESULTS IN MULTIPLE TISSUE LESIONS
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
ID FACTOR-ALPHA; TGF-BETA; FACTOR-BETA-1; LIVER; PURIFICATION; INDUCTION;
FIBROSIS; SITE
AB Aberrant expression of transforming growth factor beta 1 (TGF-beta 1) has been implicated in a number of disease processes, particularly those involving fibrotic and inflammatory lesions. To determine the in vivo effects of overexpression of TGF-beta 1 on the function and structure of hepatic as well as extrahepatic tissues, transgenic mice were generated containing a fusion gene (Alb/TGF-beta 1) consisting of modified porcine TGF-beta 1 cDNA under the control of the regulatory elements of the mouse albumin gene. Five transgenic lines were developed, all of which expressed the Alb/TGF-beta 1 transgene selectively in hepatocytes. The transgenic line 25 expressing the highest level of the transgene in the liver also had high (>10-fold over control) plasma levels of TGF-beta 1. Hepatic fibrosis and apoptotic death of hepatocytes developed in all the transgenic lines but was more pronounced in line 25. The fibrotic process was characterized by deposition of collagen around individual hepatocytes and within the space of Disse in a radiating linear pattern. Several extrahepatic lesions developed in line 25, including glomerulonephritis and renal failure, arteritis and myocarditis, as well as atrophic changes in pancreas and testis. The results from this transgenic model strongly support the proposed etiological role for TGF-beta 1 in a variety of fibrotic and inflammatory disorders, The transgenic model may also provide an appropriate paradigm for testing therapeutic interventions aimed at neutralizing the detrimental effects of this important cytokine.
C1 NCI, EXPTL CARCINOGENESIS LAB, BETHESDA, MD 20892 USA.
NCI, DIV CANC ETIOL, CHEMOPREVENT LAB, BETHESDA, MD 20892 USA.
NIDR, ORAL MED LAB, BETHESDA, MD 20892 USA.
NR 27
TC 515
Z9 531
U1 1
U2 4
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAR 28
PY 1995
VL 92
IS 7
BP 2572
EP 2576
DI 10.1073/pnas.92.7.2572
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA QP889
UT WOS:A1995QP88900034
PM 7708687
ER
PT J
AU YUAN, DS
STEARMAN, R
DANCIS, A
DUNN, T
BEELER, T
KLAUSNER, RD
AF YUAN, DS
STEARMAN, R
DANCIS, A
DUNN, T
BEELER, T
KLAUSNER, RD
TI THE MENKES-WILSON-DISEASE GENE HOMOLOG IN YEAST PROVIDES COPPER TO A
CERULOPLASMIN-LIKE OXIDASE REQUIRED FOR IRON UPTAKE
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
ID SACCHAROMYCES-CEREVISIAE; CANDIDATE GENE; TRANSPORTING ATPASE; FERRIC
REDUCTASE; PROTEIN; METABOLISM; ENCODES; CLONING
AB The CCC2 gene of the yeast Saccharomyces cerevisiae is homologous to the human genes defective in Wilson disease and Menkes disease. A biochemical hallmark of these diseases is a deficiency of copper in ceruloplasmin and other copper proteins found in extracytosolic compartments. Here we demonstrate that disruption of the yeast CCC2 gene results in defects in respiration and iron uptake. These defects could be reversed by supplementing cells with copper. suggesting that CCC2 mutant cells were copper deficient, However, cytosolic copper levels and copper uptake were normal. Instead, CCC2 mutant cells lacked a copper-dependent oxidase activity associated with the estracytosolic domain of the FET3-encoded protein, a ceruloplasmin homologue previously shown to be necessary for high-affinity iron uptake in yeast. Copper restored oxidase activity both in vitro and in vivo, paralleling the ability of copper to restore respiration and iron uptake. These results suggest that the CCC2-encoded protein is required for the export of copper from the cytosol into an estracytosolic compartment, supporting the proposal that intracellular copper transport is impaired in Wilson disease and Menkes disease.
C1 NICHHD, CELL BIOL & METAB BRANCH, BETHESDA, MD 20892 USA.
UNIFORMED SERV UNIV HLTH SCI, DEPT BIOCHEM, BETHESDA, MD 20814 USA.
NR 40
TC 358
Z9 363
U1 2
U2 8
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAR 28
PY 1995
VL 92
IS 7
BP 2632
EP 2636
DI 10.1073/pnas.92.7.2632
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA QP889
UT WOS:A1995QP88900046
PM 7708696
ER
PT J
AU PASTAN, IH
ARCHER, GE
MCLENDON, RE
FRIEDMAN, HS
FUCHS, HE
WANG, QC
PAI, LH
HERNDON, J
BIGNER, DD
AF PASTAN, IH
ARCHER, GE
MCLENDON, RE
FRIEDMAN, HS
FUCHS, HE
WANG, QC
PAI, LH
HERNDON, J
BIGNER, DD
TI INTRATHECAL ADMINISTRATION OF SINGLE-CHAIN IMMUNOTOXIN, LMB-7
[B3(FV)-PE38], PRODUCES CURES OF CARCINOMATOUS MENINGITIS IN A RAT MODEL
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
ID MONOCLONAL-ANTIBODIES; NEOPLASTIC MENINGITIS; TUMOR XENOGRAFTS; FV;
BINDING; MACROMOLECULES; PENETRATION; FRAGMENT; THERAPY; MICE
AB LMB-7 [B3(Fv)-PE38] is a single-chain immunotoxin constructed from the murine monoclonal antibody B3 and a truncated form of Pseudomonas exotoxin PE38. Antibody B3 recognizes a carbohydrate epitope found on solid tumors that frequently invade the intrathecal space and cause neoplastic meningitis. We tested the therapeutic value of intrathecally administered LMB-7 by using a model of human neoplastic meningitis in athymic rats. This model is representative of a clinical situation in that antibody B3 cross-reacts with a number of normal tissues that can be used to monitor potential systemic toxicity. Treatment was begun 3 days after A431 tumor implantation. Without treatment, the animals median survival was 10 days. Intrathecal administration of 10 mu g of LMB-7 in 40 mu l on days 3, 5, and 7 produced 4 of 10 and 8 of 10 long-term survivors (> 170 days) in two experiments. Of the long-term survivors, 2 of 4 and 7 of 8 survivors had no microscopic evidence of tumor and were considered histologic cures. Lack of significant toxicity in the effective dose range and specificity make LMB-7 an excellent candidate for intrathecal treatment of neoplastic meningitis in humans.
C1 DUKE UNIV,MED CTR,DEPT PATHOL,DURHAM,NC 27710.
DUKE UNIV,MED CTR,PREUSS LAB BRAIN TUMOR RES,DURHAM,NC 27710.
DUKE UNIV,MED CTR,DIV BIOMETRY,DURHAM,NC 27710.
RP PASTAN, IH (reprint author), NCI,DIV CANC BIOL DIAG & CTR,MOLEC BIOL LAB,37 CONVENT DR,MSC 4255,BETHESDA,MD 20892, USA.
FU NCI NIH HHS [CA 56115, CA 11898]; NINDS NIH HHS [NS 20023]
NR 31
TC 33
Z9 35
U1 0
U2 2
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAR 28
PY 1995
VL 92
IS 7
BP 2765
EP 2769
DI 10.1073/pnas.92.7.2765
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA QP889
UT WOS:A1995QP88900073
PM 7708720
ER
PT J
AU MATTHEW, E
ANDREASON, P
PETTIGREW, K
CARSON, RE
HERSCOVITCH, P
COHEN, R
KING, C
JOHANSON, CE
GREENBLATT, DJ
PAUL, SM
AF MATTHEW, E
ANDREASON, P
PETTIGREW, K
CARSON, RE
HERSCOVITCH, P
COHEN, R
KING, C
JOHANSON, CE
GREENBLATT, DJ
PAUL, SM
TI BENZODIAZEPINE RECEPTORS MEDIATE REGIONAL BLOOD-FLOW CHANGES IN THE
LIVING HUMAN BRAIN
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE (H2O)-O-15 POSITRON-EMISSION TOMOGRAPHY
ID POSITRON EMISSION TOMOGRAPHY; CEREBRAL GLUCOSE-UTILIZATION; CENTRAL
NERVOUS-SYSTEM; ANTAGONIST RO 15-1788; DIAZEPAM; METABOLISM; BINDING;
LORAZEPAM; AGONISTS; DISORDER
AB We studied the effects of a high-affinity gamma-aminobutyric acid (GABA) -benzodiazepine-receptor agonist (lorazepam) and an antagonist (flumazenil) in humans, using (H2O)-O-15 positron-emission tomography. Administration of lorazepam to healthy volunteers caused time- and dose-dependent reductions in regional cerebral blood flow and self-reported alterations in behavioral/mood parameters. Flumazenil administration reversed these changes. These observations indicated that benzodiazepine-induced effects on regional cerebral blood flow and mood/behavior are mediated at some level through GABA-benzodiazepine receptors, although the specific mechanism remains unclear. The approach described here provides a method for quantifying GABA-benzodiazepine-receptor-mediated neurotransmission in the living human brain and mag be useful for studying the role of these receptors in a variety of neuropsychiatric disorders.
C1 NIMH,CLIN NEUROSCI BRANCH,BETHESDA,MD 20892.
NIMH,CLIN BRAIN IMAGING SECT,CEREBRAL BLOOD FLOW & METAB LAB,BETHESDA,MD 20892.
NIMH,DIV EPIDEMIOL & SERV RES,BETHESDA,MD 20892.
NIH,DEPT NUCL MED,PET SECT,BETHESDA,MD 20892.
NIH,DEPT NUCL MED,PET SECT,BETHESDA,MD 20892.
UNIFORMED SERV UNIV HLTH SCI,DEPT PSYCHIAT,BETHESDA,MD 20215.
TUFTS UNIV,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,BOSTON,MA 02111.
RI Carson, Richard/H-3250-2011
OI Carson, Richard/0000-0002-9338-7966
NR 32
TC 35
Z9 36
U1 0
U2 2
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAR 28
PY 1995
VL 92
IS 7
BP 2775
EP 2779
DI 10.1073/pnas.92.7.2775
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA QP889
UT WOS:A1995QP88900075
PM 7708722
ER
PT J
AU PEOPLES, RW
WEIGHT, FF
AF PEOPLES, RW
WEIGHT, FF
TI CUTOFF IN POTENCY IMPLICATES ALCOHOL INHIBITION OF N-METHYL-D-ASPARTATE
RECEPTORS IN ALCOHOL-INTOXICATION
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE GLUTAMATE RECEPTOR; ION CHANNEL; NEUROTRANSMITTER
ID LONG-TERM POTENTIATION; CHANNEL COMPLEX; CHAIN ALCOHOLS; MEMBRANES;
DRUGS
AB As the number of carbon atoms in an aliphatic n-alcohol is increased from one to five, intoxicating potency, lipid solubility, and membrane lipid disordering potency all increase in a similar exponential manner. However, the potency of aliphatic n-alcohols for producing intoxication reaches a maximum at six to eight carbon atoms and then decreases. The molecular basis of this ''cutoff'' effect is not understood, as it is not correlated with either the lipid solubility or the membrane disordering potency of the alcohols, which continue to increase exponentially. Since it has been suggested that inhibition of N-methyt-D-aspartate (NR-IDA) receptors by alcohols may play a role in alcohol intoxication, we investigated whether a series of aliphatic n-alcohols would exhibit a cutoff in potency for inhibition of NMDA receptors. We found that although potency for inhibition of NMDA receptors increased exponentially for alcohols with one to five carbon atoms, potency for inhibition of NMDA receptors reached a maximum at six to eight carbon atoms and then abruptly disappeared. This cutoff for alcohol inhibition of NMDA receptors is consistent with an interaction of the alcohols with a hydrophobic pocket on the receptor protein. In addition, the similarity of the cutoffs for alcohol inhibition of NMDA receptors and alcohol intoxication suggests that the cutoff for NMDA receptor inhibition may contribute to the cutoff for alcohol intoxication, which is consistent with an important role of NMDA receptors in alcohol intoxication.
RP PEOPLES, RW (reprint author), NIAAA,MOLEC & CELLULAR NEUROBIOL LAB,12501 WASHINTON AVE,ROCKVILLE,MD 20852, USA.
NR 30
TC 97
Z9 98
U1 0
U2 0
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAR 28
PY 1995
VL 92
IS 7
BP 2825
EP 2829
DI 10.1073/pnas.92.7.2825
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA QP889
UT WOS:A1995QP88900085
PM 7708732
ER
PT J
AU WOODWORTH, CD
MCMULLIN, E
IGLESIAS, M
PLOWMAN, GD
AF WOODWORTH, CD
MCMULLIN, E
IGLESIAS, M
PLOWMAN, GD
TI INTERLEUKIN-1-ALPHA AND TUMOR-NECROSIS-FACTOR-ALPHA STIMULATE AUTOCRINE
AMPHIREGULIN EXPRESSION AND PROLIFERATION OF HUMAN
PAPILLOMAVIRUS-IMMORTALIZED AND CARCINOMA-DERIVED CERVICAL
EPITHELIAL-CELLS
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE KERATINOCYTE; EPIDERMAL GROWTH FACTOR; PROINFLAMMATORY CYTOKINES;
CERVICAL CANCER
ID GROWTH FACTOR-ALPHA; HUMAN KERATINOCYTES; TRANSFORMED-CELLS;
HUMAN-FIBROBLASTS; FACTOR RECEPTOR; CANCER; TYPE-16; LINES;
INFLAMMATION; CYTOKINES
AB Infection with multiple sexually transmitted agents has been associated with inflammation of the cervix and an increased risk of cervical cancer in women infected with human papillomaviruses (HPVs). Two proinflammatory cytokines, interleukin 1 alpha (IL-1 alpha) and tumor necrosis factor alpha (TNF-alpha), inhibited proliferation of normal epithelial cells cultured from human cervix. In contrast, both cytokines significantly stimulated proliferation of cervical cell lines (5 of 7) immortalized by transfection with HPV-16 or -18 DNAs or lines derived from cervical carcinomas (7 of 11). Stimulation was dose dependent from 0.01 to 1.0 nM and was blocked by specific inhibitors, such as the IL-1 receptor antagonist or the TNF type 1 or 2 soluble receptors. Growth stimulation by IL-1 alpha or TNF-alpha was accompanied by a 6- to 10-fold increase in RNA encoding amphiregulin, an epidermal growth factor (EGF) receptor ligand. Recombinant human amphiregulin (0.1 nM) was as effective as IL-1 alpha or TNF-alpha in promoting proliferation. Monoclonal antibodies that blocked signal transduction by the EGF receptor or that neutralized amphiregulin activity prevented mitogenic stimulation by IL-1 alpha or TNF-alpha. These studies indicate that IL-1 alpha and TNF-alpha stimulate proliferation of immortal and malignant cervical epithelial cells by an EGF receptor-dependent pathway requiring autocrine stimulation by amphiregulin. Furthermore, they suggest that chronic inflammation and release of proinflammatory cytokines might provide a selective growth advantage for abnormal cervical cells in vivo.
C1 SUGEN INC,REDWOOD CITY,CA 94063.
RP WOODWORTH, CD (reprint author), NCI,BIOL LAB,BETHESDA,MD 20892, USA.
RI PLOWMAN, Greg/E-2012-2011
NR 35
TC 110
Z9 113
U1 0
U2 6
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAR 28
PY 1995
VL 92
IS 7
BP 2840
EP 2844
DI 10.1073/pnas.92.7.2840
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA QP889
UT WOS:A1995QP88900088
PM 7708734
ER
PT J
AU SCHWAN, TG
PIESMAN, J
GOLDE, WT
DOLAN, MC
ROSA, PA
AF SCHWAN, TG
PIESMAN, J
GOLDE, WT
DOLAN, MC
ROSA, PA
TI INDUCTION OF AN OUTER SURFACE PROTEIN ON BORRELIA-BURGDORFERI DURING
TICK FEEDING
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE IXODES SCAPULARIS; LYME DISEASE; BLOOD MEAL; OUTER SURFACE PROTEIN C;
TEMPERATURE
ID LYME-DISEASE; IXODES-DAMMINI; MONOCLONAL-ANTIBODY; OSPC GENE;
TRANSMISSION; EXPRESSION; VIRULENCE; LIPOPROTEIN; ATTACHMENT; BACTERIA
AB Lyme disease spirochetes, Borrelia burgdorferi sensu lato, are maintained in zoonotic cycles involving ticks and small mammals. In unfed ticks, the spirochetes produce one outer surface protein, OspA, but not OspC. During infection in mammals, immunological data suggest that the spirochetes have changed their surface, now expressing OspC but little or no OspA. We find by in vitro growth experiments that this change is regulated in part by temperature; OspC is produced by spirochetes at 32-37 degrees C but not at 24 degrees C. Furthermore, spirochetes in the midgut of ticks that have fully engorged on mice now have OspC on their surface. Thus two environmental cues, an increase in temperature and tick feeding, trigger a major alteration of the spirochetal outer membrane. This rapid synthesis of OspC by spirochetes during tick feeding may play an essential role in the capacity of these bacteria to successfully infect mammalian hosts, including humans, when transmitted by ticks.
C1 CTR DIS CONTROL & PREVENT,NATL CTR INFECT DIS,DIV VECTOR BORNE INFECT DIS,FT COLLINS,CO 80522.
RP SCHWAN, TG (reprint author), NIAID,ROCKY MT LABS,MICROBIAL STRUCT & FUNCT LAB,HAMILTON,MT 59840, USA.
NR 46
TC 638
Z9 644
U1 0
U2 27
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAR 28
PY 1995
VL 92
IS 7
BP 2909
EP 2913
DI 10.1073/pnas.92.7.2909
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA QP889
UT WOS:A1995QP88900102
PM 7708747
ER
PT J
AU YANG, YL
BAILEY, J
VACCHIO, MS
YARCHOAN, R
ASHWELL, JD
AF YANG, YL
BAILEY, J
VACCHIO, MS
YARCHOAN, R
ASHWELL, JD
TI RETINOIC ACID INHIBITION OF EX-VIVO HUMAN IMMUNODEFICIENCY
VIRUS-ASSOCIATED APOPTOSIS OF PERIPHERAL-BLOOD CELLS
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
ID ACTIVATION-INDUCED APOPTOSIS; ACUTE PROMYELOCYTIC LEUKEMIA; MATURE
T-CELLS; DEATH APOPTOSIS; HIV-INFECTION; EXPRESSION; AIDS; DYSFUNCTION;
RECEPTOR; ANTIGEN
AB T cells from human immunodeficiency virus (HIV)-infected individuals undergo spontaneous and activation-induced ex vivo apoptosis, Here we report that peripheral blood mononuclear cells (PBMCs) obtained from six HIV-infected individuals exhibited reduced ex vivo DNA fragmentation and cell death after ingestion of all-trans-retinoic acid (tRA). These effects were attenuated with continued daily RA administration, which correlated with a >5-fold decrease in serum peak RA concentrations, Incubation of PBMCs from HIV+ individuals with tRA in vitro resulted in decreased DNA fragmentation in a subset of patients, especially those having <500 CD4(+) T cells per mm(3). tRA also inhibited apoptosis of preactivated normal PBMCs induced to die by restimulation, which raises the possibility of a common mechanism between activation-induced apoptosis of activated normal PBMCs and apoptosis associated with HIV infection, Whether HIV-associated apoptosis of PBMCs, and its prevention by RA, has an impact on T-cell survival or the course of disease in patients infected with HIV will require further evaluation.
C1 NCI,CLIN ONCOL PROGRAM,BETHESDA,MD 20892.
RP YANG, YL (reprint author), NCI,BIOL RESPONSE MODIFIERS PROGRAM,IMMUNE CELL BIOL LAB,BETHESDA,MD 20892, USA.
NR 39
TC 44
Z9 46
U1 0
U2 0
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAR 28
PY 1995
VL 92
IS 7
BP 3051
EP 3055
DI 10.1073/pnas.92.7.3051
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA QP889
UT WOS:A1995QP88900131
PM 7708773
ER
PT J
AU HONG, JX
ZHANG, XK
MOSS, J
VAUGHAN, M
AF HONG, JX
ZHANG, XK
MOSS, J
VAUGHAN, M
TI ISOLATION OF AN AMINO-TERMINAL DELETED RECOMBINANT ADP-RIBOSYLATION
FACTOR-1 IN AN ACTIVATED NUCLEOTIDE-FREE STATE
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
ID GUANINE-NUCLEOTIDE; CHOLERA-TOXIN; BINDING PROTEINS; BREFELDIN-A; GOLGI
MEMBRANES; BOVINE BRAIN; HUMAN GENE; GTP; ARF; RIBOSYLTRANSFERASE
AB ADP-ribosylation factors (ARFs) are approximate to 20-kDa guanine nucleotide-binding proteins that activate cholera toxin ADP-ribosyltransferase in vitro and participate in intracellular vesicular membrane trafficking. ARFs are activated when bound GDP is replaced by GTP and inactivated by hydrolysis of bound GTP to yield ARF-GDP. Usually, ARFs are isolated in an inactive GDP-bound state and require addition of GTP along with detergent or phospholipid for activity, Purified mutant recombinant ARF1 lacking the first 13 amino acids (r Delta 13ARF1-P) stimulated cholera toxin activity essentially equally with or without added GTP (and phospholipid or detergent), at least in part due to the presence of bound nucleotides, which later were identified as GTP and GDP. Nucleotide-free r Delta 13ARF1 (r Delta 13ARF1-F), prepared by dialysis against 7 M urea, was active without added GTP in the absence of SDS but inactive without added GTP in its presence. Renaturation of r Delta 13ARF1-F in the presence of GTP, ITP, or GDP yielded, respectively, r Delta 13ARF1-GTP and r Delta 13ARF1-ITP, which were active, and r Delta 13ARF1-GDP, which was inactive, Effects of phospholipids and detergents on nucleotide exchangeability evaluated as effects on activity of rARF1 and r Delta 13ARF1-F differed. With r Delta 13ARF1-F, 100 mu M ITP and 100 mu M GTP were essentially equally effective in the presence of cardiolipin or SDS. The finding that r Delta 13ARF1 differs from rARF1 in the effects of phospholipids and detergents on nucleotide binding is consistent with the conclusion that the ARF amino terminus plays an important role in nucleotide binding and its specificity as well as the molecular conformation and associated activity,
C1 NHLBI,BIOPHYS CHEM LAB,BETHESDA,MD 20892.
RP HONG, JX (reprint author), NHLBI,PULM CRIT CARE MED BRANCH,BLDG 10,BETHESDA,MD 20892, USA.
NR 28
TC 12
Z9 15
U1 0
U2 0
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAR 28
PY 1995
VL 92
IS 7
BP 3056
EP 3059
DI 10.1073/pnas.92.7.3056
PG 4
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA QP889
UT WOS:A1995QP88900132
PM 7708774
ER
PT J
AU SEPEHRNIA, B
PREZANT, TR
ROTTER, JI
PETTITT, DJ
KNOWLER, WC
FISCHELGHODSIAN, N
AF SEPEHRNIA, B
PREZANT, TR
ROTTER, JI
PETTITT, DJ
KNOWLER, WC
FISCHELGHODSIAN, N
TI SCREENING FOR MTDNA DIABETES MUTATIONS IN PIMA-INDIANS WITH NIDDM
SO AMERICAN JOURNAL OF MEDICAL GENETICS
LA English
DT Article
DE MITOCHONDRIAL MUTATIONS; DIABETES MELLITUS; PIMA INDIANS
ID MITOCHONDRIAL-DNA; MELLITUS; DEAFNESS; GENE; SUSCEPTIBILITY;
TRANSMISSION; PREVALENCE; DELETION; OBESITY; LINKAGE
AB More than half of the Pima Indians over age 35 years have non-insulin-dependent (type II) diabetes mellitus (NIDDM). Extensive data indicate the importance of maternal diabetes in determining their risk for diabetes. Generally, the risk of having NIDDM is higher in patients with affected mothers than affected fathers. This has been attributed to intrauterine factors, but recently mitochondrial inheritance has been raised as an alternative hypothesis. In other populations, several families and individuals with diabetes due to a mitochondrial DNA point mutation at nucleotide 3243 in the tRNA(leu(UUR)), gene have been described, as has one family with a 10.4 kb mitochondrial DNA duplication/deletion. We tested whether these specific mitochondrial gene mutations could explain a portion of the excess maternal transmission seen in the Pima Indians. Mitochondrial DNA obtained from blood lymphocytes of 148 Pima Indians with NIDDM was screened both for the point mutation at nt 3243, and the 10.4 kb duplication/deletion. Neither of these mutations was detected, and although a small proportion of the excess maternal transmission in Pima Indians could still be due to yet undescribed mitochondrial mutations or imprinted nuclear genes, our data support the role of the intrauterine environment in this population. (C) 1995 Wiley-Liss, Inc.
C1 CEDARS SINAI RES INST,CTR MED GENET BIRTH DEFECTS,STEVEN SPIELBERG PEDIAT RES CTR,LOS ANGELES,CA.
UNIV CALIF LOS ANGELES,SCH MED,LOS ANGELES,CA.
NIDDKD,DIABET & ARTHRITIS EPIDEMIOL SECT,PHOENIX,AZ.
FU NHLBI NIH HHS [HL 07386]
NR 32
TC 13
Z9 14
U1 0
U2 1
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0148-7299
J9 AM J MED GENET
JI Am. J. Med. Genet.
PD MAR 27
PY 1995
VL 56
IS 2
BP 198
EP 202
DI 10.1002/ajmg.1320560217
PG 5
WC Genetics & Heredity
SC Genetics & Heredity
GA QQ365
UT WOS:A1995QQ36500016
PM 7625445
ER
PT J
AU PRIEL, E
AFLALO, E
SERI, I
HENDERSON, LE
ARTHUR, LO
ABOUD, M
SEGAL, S
BLAIR, DG
AF PRIEL, E
AFLALO, E
SERI, I
HENDERSON, LE
ARTHUR, LO
ABOUD, M
SEGAL, S
BLAIR, DG
TI DNA-BINDING PROPERTIES OF THE ZINC-BOUND AND ZINC-FREE HIV NUCLEOCAPSID
PROTEIN - SUPERCOILED DNA UNWINDING AND DNA-PROTEIN CLEAVABLE
COMPLEX-FORMATION
SO FEBS LETTERS
LA English
DT Article
DE HIV NUCLEOCAPSID PROTEIN; SUPERCOILED DNA; DNA-PROTEIN COMPLEX
ID IMMUNODEFICIENCY-VIRUS TYPE-1; LEUKEMIA-VIRUS; TOPOISOMERASE-I;
NUCLEIC-ACIDS; GENOMIC RNA; VIRAL-DNA; RETROVIRUSES; SEQUENCES;
MUTATIONS; MUTANTS
AB The HIV nucleocapsid (NC) protein contains, as those of other retroviruses, two Cys-His arrays which function as zinc finger binding domains. The nucleic acid binding properties of retroviral NC have been previously demonstrated. In this study, we characterized the DNA binding ability of the zinc-bound and zinc-free forms of HIV NC. We found that in addition to binding single-stranded DNA, both forms bind and unwind supercoiled plasmid DNA. The binding ability of the zinc-bound form was higher than the zinc-free form. In addition we showed the formation of NC protein-DNA cleavable complex which is the result of a presumably covalent bond formed between the protein and the phosphate moiety of the DNA backbone. The NC unwinding activity and the protein-DNA cleavable complex formation resembles the first step of the relaxing mechanism of DNA topoisomerase. Our results shed light on the possibility of a novel physiological function for the HIV NC protein in the viral life cycle.
C1 NCI,FREDERICK CANC RES & DEV CTR,PRI DYNCORP,AIDS VACCINE PROGRAM,FREDERICK,MD 21702.
NCI,FREDERICK CANC RES & DEV CTR,MOLEC ONCOL LAB,MICROBIOL SECT,FREDERICK,MD 21702.
RP PRIEL, E (reprint author), BEN GURION UNIV NEGEV,FAC HLTH SCI,CANC RES CTR,DEPT IMMUNOL & MICROBIOL,BEER SHEVA,ISRAEL.
NR 30
TC 14
Z9 14
U1 0
U2 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-5793
J9 FEBS LETT
JI FEBS Lett.
PD MAR 27
PY 1995
VL 362
IS 1
BP 59
EP 64
DI 10.1016/0014-5793(95)00208-Q
PG 6
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA QQ058
UT WOS:A1995QQ05800014
PM 7698354
ER
PT J
AU PU, LP
HAYES, WP
MILL, JF
GHOSE, S
FRIEDMAN, TC
LOH, YP
AF PU, LP
HAYES, WP
MILL, JF
GHOSE, S
FRIEDMAN, TC
LOH, YP
TI FROG PROHORMONE CONVERTASE PC2 MESSENGER-RNA HAS A MAMMALIAN-LIKE
EXPRESSION PATTERN IN THE CENTRAL-NERVOUS-SYSTEM AND IS COLOCALIZED WITH
A SUBSET OF THYROTROPIN-RELEASING HORMONE-EXPRESSING NEURONS
SO JOURNAL OF COMPARATIVE NEUROLOGY
LA English
DT Article
DE BRAIN; IN SITU HYBRIDIZATION HISTOCHEMISTRY; NEUROPEPTIDES; PROCESSING
ENZYME; XENOPUS LAEVIS
ID XENOPUS-LAEVIS; RANA-ESCULENTA; RAT-BRAIN; IMMUNOHISTOCHEMICAL
LOCALIZATION; IMMUNOCYTOCHEMICAL EVIDENCE; PROPROTEIN CONVERTASES;
PROCESSING PROTEINASES; MEDIAN-EMINENCE; MESSENGER-RNAS; CDNA STRUCTURE
AB The prohormone convertase (PC2) is expressed in the mammalian central nervous system (CNS) and has been shown to play an important role in the processing of certain neuropeptide precursors and prohormones at paired basic residues. Amphibian PC2 cDNA was recently cloned for the frog Xenopus laevis, and both its sequence and its pituitary expression pattern were shown to be very similar to those of mammalian PC2. To investigate further the function of PC2 in the vertebrate CNS, we used in situ hybridization histochemistry to localize the distribution of cells expressing PC2 mRNA in the frog brain and the spinal cord. The distribution of PC2-expressing cells was also compared with that of cells expressing thyrotropin-releasing hormone (TRH) mRNA or peptide. PC2-expressing cells were detected in specific nuclei that were widely distributed in the frog CNS. In forebrain, telencephalic PC2 mRNA was found in the olfactory bulb, pallium, striatum, amygdala, and septum, and diencephalic PC2 mRNA was seen in the preoptic area, thalamus, and hypothalamus. More posteriorly, PC2 cells were localized to midbrain tegmentum, the torus semicircularis, and the optic tectum, as well as the cerebellum, brainstem, and spinal cord. Despite this wide distribution, steady-state levels of PC2 mRNA were clearly different in various brain nuclei. Regions with higher levels showed good correspondence to areas shown by others in frog to contain large numbers of neuropeptide expressing cells, including TRH cells. On the other hand, not all brain areas with high levels of TRH mRNA had high levels of PC2 mRNA. Localization studies combining in situ hybridization and immunocytochemistry showed that, at least in optic tectum and brainstem, PC2 mRNA and pro-TRH peptide coexist. These findings suggest that pro-TRH is processed by PC2 in some, but possibly not all, brain regions. Thus, different converting enzymes may be involved in pro-TRH processing in different brain regions. (C) 1995 Wiley-Liss, Inc.*
C1 NICHHD,DEV NEUROBIOL LAB,CELLULAR NEUROBIOL SECT,BETHESDA,MD 20892.
NINCDS,MOLEC BIOL LAB,BETHESDA,MD 20892.
RI Ghose, Subroto/J-6732-2016
NR 65
TC 12
Z9 12
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0021-9967
J9 J COMP NEUROL
JI J. Comp. Neurol.
PD MAR 27
PY 1995
VL 354
IS 1
BP 71
EP 86
DI 10.1002/cne.903540107
PG 16
WC Neurosciences; Zoology
SC Neurosciences & Neurology; Zoology
GA QL999
UT WOS:A1995QL99900006
PM 7615876
ER
PT J
AU DANIELPOUR, D
ROBERTS, AB
AF DANIELPOUR, D
ROBERTS, AB
TI SPECIFIC AND SENSITIVE QUANTITATION OF TRANSFORMING GROWTH-FACTOR BETA-3
BY SANDWICH ENZYME-LINKED-IMMUNOSORBENT-ASSAY
SO JOURNAL OF IMMUNOLOGICAL METHODS
LA English
DT Article
DE ELISA; TRANSFORMING GROWTH FACTOR BETA-3; IGY, CHICKEN; PURIFICATION;
UMBILICAL CORD; (SERUM)
ID DIFFERENTIAL REGULATION; EXPRESSION; IDENTIFICATION; FACTOR-BETA-2;
PROMOTER; SEQUENCE; ACID
AB Transforming growth factors beta (TGF-beta) consist of a highly homologous family of 25 kDa dimers involved in a diverse array of biological functions. Progress in understanding the biology of the third isoform (TGF-beta 3) of this family has been limited by the absence of a quantitative assay for TGF-beta 3. Here we report the development of a sensitive and specific sandwich enzyme-linked immunosorbent assay (SELISA), which is based on an anti-TGF-beta mouse monoclonal IgG as the capture antibody and chicken anti-recombinant-hTGF-beta 3 IgY as the secondary antibody. This assay can quantitate TGF-beta 3 in complex biological fluids, with a detection limit of 2 pg and no cross-reactivity or inteference with as high as 1000-fold molar excesses of either TGF-beta s 1, 2 or 1.2. This TGF-beta 3 SELISA is the first reported assay for the direct and sensitive quantitation of TGF-beta 3 in complex biological fluids.
RP DANIELPOUR, D (reprint author), NCI,CHEMOPREVENT LAB,BLDG 41,ROOM C629,BETHESDA,MD 20892, USA.
NR 19
TC 21
Z9 23
U1 1
U2 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-1759
J9 J IMMUNOL METHODS
JI J. Immunol. Methods
PD MAR 27
PY 1995
VL 180
IS 2
BP 265
EP 272
DI 10.1016/0022-1759(94)00322-N
PG 8
WC Biochemical Research Methods; Immunology
SC Biochemistry & Molecular Biology; Immunology
GA QQ910
UT WOS:A1995QQ91000012
PM 7714341
ER
PT J
AU FLEMING, K
GOLDBERG, TE
GOLD, JM
WEINBERGER, DR
AF FLEMING, K
GOLDBERG, TE
GOLD, JM
WEINBERGER, DR
TI VERBAL WORKING-MEMORY DYSFUNCTION IN SCHIZOPHRENIA - USE OF A
BROWN-PETERSON PARADIGM
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE NEUROPSYCHOLOGY; COGNITION; FRONTAL LOBE; MNEMONIC PERFORMANCE
ID MONKEY PREFRONTAL CORTEX; DELAYED-RESPONSE TASK; CONNECTIONIST APPROACH;
COGNITIVE DEFICIT; DOPAMINE; INTERFERENCE; INVOLVEMENT; REHEARSAL;
DEMENTIA
AB Recent studies of schizophrenia have implicated deficits in processes related to working memory, but the cognitive features of these deficits have been incompletely characterized. We used a modified Brown-Peterson paradigm to compare working memory in patients with schizophrenia and in normal control subjects. Distracter conditions differed in processing demand, increasing in complexity from no distracter to counting backwards (serial threes). We found significant effects of group, of distracter condition, and of a group x distracter condition interaction. The significant interaction was the result of a more rapid decline in the performance of schizophrenic patients with concurrent articulation. In addition, the schizophrenic group also made significantly more intrusion errors. The study suggests that schizophrenic patients exhibit dysfunction of the verbal working memory system due to a diminution in its overall processing resources.
C1 NIMH,NEUROSCI CTR ST ELIZABETHS,WASHINGTON,DC 20032.
NR 43
TC 85
Z9 85
U1 1
U2 3
PU ELSEVIER SCI PUBL IRELAND LTD
PI CLARE
PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE,
IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD MAR 27
PY 1995
VL 56
IS 2
BP 155
EP 161
DI 10.1016/0165-1781(95)02589-3
PG 7
WC Psychiatry
SC Psychiatry
GA RB753
UT WOS:A1995RB75300006
PM 7667440
ER
PT J
AU BAXEVANIS, AD
BRYANT, SH
LANDSMAN, D
AF BAXEVANIS, AD
BRYANT, SH
LANDSMAN, D
TI HOMOLOGY MODEL-BUILDING OF THE HMG-1 BOX STRUCTURAL DOMAIN
SO NUCLEIC ACIDS RESEARCH
LA English
DT Article
ID TESTIS-DETERMINING GENE; HISTONE CHROMOSOMAL-PROTEINS; TRANSCRIPTION
FACTOR UBF; DNA-BINDING PROTEIN; MINOR-GROOVE; CRYSTAL-STRUCTURE;
SEQUENCE; SRY; MOTIF; COMPLEX
AB Nucleoproteins belonging to the HMG-1/-2 family possess homologous domains similar to 75 amino acids in length. These domains, termed HMG-1 boxes, are highly structured, compact, and mediate the interaction between HMG-1 box-containing proteins and DNA in a variety of biological contexts. Homology model building experiments on HMG-1 box sequences 'threaded' through the H-1-NMR structure of an HMG-1 box from rat indicate that the domain does not have rigid sequence requirements for its formation. Energy calculations indicate that the structure of all HMG-1 box domains is stabilized primarily through hydrophobic interactions. We have found structural relationships in the absence of statistically significant sequence similarity, identifying several candidate proteins which could possibly assume the same three-dimensional conformation as the rat HMG-1 box motif. The threading technique provides a method by which significant structural similarities in a diverse protein family can be efficiently detected, and the 'structural alignment' derived by this method provides a rational basis through which phylogenetic relationships and the precise sites of interaction between HMG-1 box proteins and DNA can be deduced.
C1 NATL INST HLTH,NATL LIB MED,NATL CTR BIOTECHNOL INFORMAT,BETHESDA,MD 20894.
RI Landsman, David/C-5923-2009;
OI Landsman, David/0000-0002-9819-6675
NR 57
TC 23
Z9 23
U1 0
U2 1
PU OXFORD UNIV PRESS UNITED KINGDOM
PI OXFORD
PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP
SN 0305-1048
J9 NUCLEIC ACIDS RES
JI Nucleic Acids Res.
PD MAR 25
PY 1995
VL 23
IS 6
BP 1019
EP 1029
DI 10.1093/nar/23.6.1019
PG 11
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QU682
UT WOS:A1995QU68200020
PM 7731789
ER
PT J
AU ABOUSSEKHRA, A
BIGGERSTAFF, M
SHIVJI, MKK
VILPO, JA
MONCOLLIN, V
PODUST, VN
PROTIC, M
HUBSCHER, U
EGLY, JM
WOOD, RD
AF ABOUSSEKHRA, A
BIGGERSTAFF, M
SHIVJI, MKK
VILPO, JA
MONCOLLIN, V
PODUST, VN
PROTIC, M
HUBSCHER, U
EGLY, JM
WOOD, RD
TI MAMMALIAN DNA NUCLEOTIDE EXCISION-REPAIR RECONSTITUTED WITH PURIFIED
PROTEIN-COMPONENTS
SO CELL
LA English
DT Article
ID CELL NUCLEAR ANTIGEN; PIGMENTOSUM GROUP-F; BINDING-PROTEIN; DAMAGED DNA;
REPLICATION PROTEIN; POLYMERASE-DELTA; TRANSCRIPTION FACTOR; PRIMATE
CELLS; LIGASE-I; PURIFICATION
AB Nucleotide excision repair is the principal way by which human cells remove UV damage from DNA. Human cell extracts were fractionated to locate active components, including xeroderma pigmentosum (XP) and ERCC factors. The incision reaction was then reconstituted with the purified proteins RPA, XPA, TFIIH (containing XPB and XPD), XPC, UV-DDB, XPG, partially purified ERCC1/XPF complex, and a factor designated IF7. UV-DDB (related to XPE protein) stimulated repair but was not essential. ERCC1- and XPF-correcting activity copurified with an ERCC1-binding polypeptide of 110 kDa that was absent in XP-F cell extract. Complete repair synthesis was achieved by combining these factors with DNA polymerase epsilon, RFC, PCNA, and DNA ligase I. The reconstituted core reaction requires about 30 polypeptides.
C1 IMPERIAL CANC RES FUND,CLARE HALL LABS,S MIMMS EN6 3LD,HERTS,ENGLAND.
INST GENET & BIOL MOLEC & CELLULAIRE,F-67404 ILLKIRCH GRAFFENS,FRANCE.
UNIV ZURICH IRCHEL,DEPT VET BIOCHEM,CH-8057 ZURICH,SWITZERLAND.
NICHHD,DNA REPLICAT REPAIR & MUTAGENESIS,BETHESDA,MD 20892.
TAMPERE UNIV HOSP,DEPT CLIN CHEM,SF-33521 TAMPERE,FINLAND.
RI Wood, Richard/E-7855-2011
OI Wood, Richard/0000-0002-9495-6892
NR 57
TC 678
Z9 692
U1 6
U2 19
PU CELL PRESS
PI CAMBRIDGE
PA 50 CHURCH ST CIRCULATION DEPT, CAMBRIDGE, MA 02138
SN 0092-8674
J9 CELL
JI Cell
PD MAR 24
PY 1995
VL 80
IS 6
BP 859
EP 868
DI 10.1016/0092-8674(95)90289-9
PG 10
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QP612
UT WOS:A1995QP61200005
PM 7697716
ER
PT J
AU JUSTICE, JM
BLIZIOTES, MM
STEVENS, LA
MOSS, J
VAUGHAN, M
AF JUSTICE, JM
BLIZIOTES, MM
STEVENS, LA
MOSS, J
VAUGHAN, M
TI INVOLVEMENT OF N-MYRISTOYLATION IN MONOCLONAL-ANTIBODY RECOGNITION SITES
ON CHIMERIC G-PROTEIN ALPHA-SUBUNITS
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID NUCLEOTIDE-BINDING-PROTEINS; ADP-RIBOSYLATION FACTOR; ROD OUTER
SEGMENTS; BETA-GAMMA; ESCHERICHIA-COLI; PLASMA-MEMBRANE; AMINO TERMINUS;
TRANSDUCIN; RHODOPSIN; RECONSTITUTION
AB Monoclonal antibody, LAS-2, directed against the alpha subunit of transducin (G(t alpha)), inhibited G(t beta gamma-)dependent, pertussis toxin-catalyzed ADP ribosylation of G(t alpha) and was specific for G(t alpha). Immunoblotting studies on proteolytic fragments of G(t alpha) were consistent with an aminoterminal epitope. To define the antibody recognition site, recombinant G(t alpha) was synthesized in Escherichia coli cotransfected with or without yeast N-myristoyltransferase. Amino-terminal fatty acylation of G(t alpha), verified by use of radiolabeled fatty acid, was required for immunoreactivity. LAS-2 did not react with a chimeric protein consisting of residues 1-9 of G(t alpha) and the remainder G(o alpha), regardless of its myristoylation. Immunoreactivity was observed when amino acids 1-17 of G(t alpha) were present in a G(o alpha) chimera and the protein was amino-terminally myristoylated; there was no reactivity without myristoylation. It appears that the LAS-S epitope requires both G(t alpha)-specific sequence in amino acids 10-17 and a fatty acyl group in proximity to these residues. These results are consistent with the hypothesis that the myristoyl group is essential for protein structure; conceivably it ''folds back'' on and stabilizes the amino-terminal structure of G(t alpha), as opposed to protruding from an amino-terminal alpha-helix and serving as an amino terminal membrane anchor.
RP JUSTICE, JM (reprint author), NHLBI,PULM CRIT CARE MED BRANCH,BLDG 10,RM 5N-307,10 CTR DR,MSC 1434,BETHESDA,MD 20892, USA.
NR 38
TC 14
Z9 14
U1 0
U2 1
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 24
PY 1995
VL 270
IS 12
BP 6436
EP 6439
PG 4
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QQ855
UT WOS:A1995QQ85500005
PM 7534763
ER
PT J
AU RYBA, NJP
TIRINDELLI, R
AF RYBA, NJP
TIRINDELLI, R
TI A NOVEL GTP-BINDING PROTEIN GAMMA-SUBUNIT, G-GAMMA-8, IS EXPRESSED
DURING NEUROGENESIS IN THE OLFACTORY AND VOMERONASAL NEUROEPITHELIA
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID ADRENERGIC-RECEPTOR KINASE; HETEROTRIMERIC G-PROTEINS;
CENTRAL-NERVOUS-SYSTEM; BETA-GAMMA; SIGNAL TRANSDUCTION;
MOLECULAR-CLONING; ADENYLYL CYCLASE; TYROSINE-PHOSPHATASE; ODORANT
RECEPTORS; GENE-EXPRESSION
AB A novel heterotrimeric G-protein gamma-subunit has been cloned, and its function has been confirmed by expression and purification. This gamma-subunit is only detected in the olfactory epithelium, the vomeronasal epithelium and, to a lesser extent, the olfactory bulb. It is absent from all other tissues studied including the nasal respiratory epithelium, During development, expression of G gamma 8 in the olfactory epithelium parallels neurogenesis, peaking shortly after birth and declining in the adult. In situ hybridization studies localize expression of this novel gamma-subunit to the sensory neurons; hybridization is strongest in the region of the epithelium that contains immature neurons, Unlike proteins that are expressed only in mature olfactory neurons (e.g. olfactory marker protein or Golf alpha), expression of G gamma 8 in the olfactory epithelium is relatively unaffected by olfactory bulbectomy. In the vomeronasal epithelium expression of G gamma 8 is also highest in the developing neurons. Taken together, these findings are consistent with a very specific role for G gamma 8 in the development and turnover of olfactory and vomeronasal neurons.
C1 UNIV PARMA,I-43100 PARMA,ITALY.
RP RYBA, NJP (reprint author), NIDR,IMMUNOL LAB,BLDG 10,RM 1A09,BETHESDA,MD 20892, USA.
NR 60
TC 60
Z9 62
U1 0
U2 1
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 24
PY 1995
VL 270
IS 12
BP 6757
EP 6767
PG 11
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QQ855
UT WOS:A1995QQ85500052
PM 7896821
ER
PT J
AU TAYLOR, ICA
ROY, S
YASWEN, P
STAMPFER, MR
VARMUS, HE
AF TAYLOR, ICA
ROY, S
YASWEN, P
STAMPFER, MR
VARMUS, HE
TI MOUSE MAMMARY-TUMORS EXPRESS ELEVATED LEVELS OF RNA-ENCODING THE MURINE
HOMOLOG OF SKY, A PUTATIVE RECEPTOR TYROSINE KINASE
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID HUMAN-BREAST-CANCER; PP60C-SRC PROTEIN-KINASE; EPITHELIAL-CELL LINE;
SIGNAL TRANSDUCTION; TRANSGENIC MICE; GROWTH-FACTOR; GENE; ONCOGENE;
TRANSFORMATION; VIRUS
AB To gain insight into the signal transduction pathways utilized by the Wnt-1-responsive mammary epithelial cell line C57MG, we screened for non-src family member tyrosine kinases expressed in these cells using a polymerase chain reaction-based technique. We identified five cDNA clones encoding receptor tyrosine kinases for which the ligand is known (fibroblast growth factor receptor, platelet-derived growth factor receptor, epithelial growth factor receptor, insulin receptor, and insulin-like growth factor receptor), two putative receptor tyrosine kinases for which the ligand remains to be identified (the products of ryk and the mouse klg homolog), and a novel tyrosine kinase. We cloned cDNAs encoding both the murine and human homologs of this kinase, the sequences of which were subsequently published under the names sky (Ohashi, K., Mizuno, K., Kuma, K., Miyata, T., and Nakamura, T. (1994) Oncogene 9, 699-705) and rse (Mark, M. R., Scadden, D. T., Wang, Z., Gu, Q., Goddard, A., and Godowski, P. J. (1994) J. Biol. Chem. 269, 10720-10728). Mouse sky RNA levels are abundant in mammary tumors derived from transgenic mice that express wnt-1, fgf-3, or both oncogenes in their mammary glands. However, little or no expression of sky is detected in mammary glands from virgin animals or in preneoplastic mammary glands from wnt-1 transgenic mice. Moreover, we find that the human homolog of sky is expressed at elevated levels when normal human mammary epithelial cells are rendered tumorigenic by the introduction of two viral oncogenes. Transient transfection of the human SKY cDNA into the quail fibrosarcoma cell line QT6 reveals that SKY is an active tyrosine kinase that augments the level of cellular phosphotyrosine. Introduction of murine Sky into RatB1a fibroblasts by retrovirus-mediated gene transfer results in morphological transformation, growth in soft agar, and the formation of tumors in nude mice. These data raise the possibility that the Sky tyrosine kinase is involved in the development and/or progression of mammary tumors.
C1 NCI,BETHESDA,MD 20892.
UNIV CALIF SAN FRANCISCO,DEPT MICROBIOL & IMMUNOL,SAN FRANCISCO,CA 94143.
UNIV CALIF BERKELEY,LAWRENCE BERKELEY LAB,BERKELEY,CA 94720.
FU NCI NIH HHS [CA-24844, CA-54247, CA-39832]
NR 37
TC 43
Z9 44
U1 0
U2 2
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 24
PY 1995
VL 270
IS 12
BP 6872
EP 6880
PG 9
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QQ855
UT WOS:A1995QQ85500066
PM 7896835
ER
PT J
AU ERNST, JA
CLUBB, RT
ZHOU, HX
GRONENBORN, AM
CLORE, GM
AF ERNST, JA
CLUBB, RT
ZHOU, HX
GRONENBORN, AM
CLORE, GM
TI DEMONSTRATION OF POSITIONALLY DISORDERED WATER WITHIN A PROTEIN
HYDROPHOBIC CAVITY BY NMR
SO SCIENCE
LA English
DT Article
ID 3-DIMENSIONAL STRUCTURE; FOLDING THERMODYNAMICS; TRYPSIN-INHIBITOR;
CRYSTAL-STRUCTURE; AQUEOUS-SOLUTION; INTERLEUKIN-1-BETA; HYDRATION;
SPECTROSCOPY; RESOLUTION; MOLECULES
AB The presence and location of water of hydration (thai is, bound water) in the solution structure of human interleukin-1 beta (hIL-1 beta) was investigated with water-selective two-dimensional heteronuclear magnetic resonance spectroscopy. It is shown here that in addition to water al the surface of the protein and ordered internal water molecules involved in bridging hydrogen bonds, positionally disordered water is present within a large, naturally occurring hydrophobic cavity located at the center oi the molecule. These water molecules of hydration have residency times in the range of 1 to 2 nanoseconds to 100 to 200 microseconds and can be readily detected by nuclear magnetic resonance (NMR). Thus, large hydrophobic cavities in proteins may not be truly empty, as analysis oi crystal structures appears to show, but may contain mobile water molecules that are crystallographically invisible but detectable by NMR.
C1 NIDDKD,CHEM PHYS LAB,BETHESDA,MD 20892.
RI Clore, G. Marius/A-3511-2008; Zhou, Huan-Xiang/M-5170-2016
OI Clore, G. Marius/0000-0003-3809-1027; Zhou,
Huan-Xiang/0000-0001-9020-0302
NR 49
TC 202
Z9 205
U1 1
U2 16
PU AMER ASSOC ADVAN SCIENCE
PI WASHINGTON
PA 1333 H ST NW, WASHINGTON, DC 20005
SN 0036-8075
J9 SCIENCE
JI Science
PD MAR 24
PY 1995
VL 267
IS 5205
BP 1813
EP 1817
DI 10.1126/science.7892604
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA QN702
UT WOS:A1995QN70200037
PM 7892604
ER
PT J
AU BOURASSA, MG
ROUBIN, GS
DETRE, KM
SOPKO, G
KRONE, RJ
ATTABUTO, MJ
BJERREGAAD, P
BOLLING, S
HERMAN, MV
FRYE, R
AF BOURASSA, MG
ROUBIN, GS
DETRE, KM
SOPKO, G
KRONE, RJ
ATTABUTO, MJ
BJERREGAAD, P
BOLLING, S
HERMAN, MV
FRYE, R
TI BYPASS ANGIOPLASTY REVASCULARIZATION INVESTIGATION - PATIENT SCREENING,
SELECTION, AND RECRUITMENT
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
AB Percutaneous transluminal coronary angioplasty (PTCA) is currently performed in many patients seeking care because of severe manifestations of multivessel coronary artery disease. Previously, the majority of such patients would have undergone coronary artery bypass grafting (CABG). No definitive evidence is available as to which initial revascularization strategy has the best long-term clinical and economic outcomes. The Bypass Angioplasty Revascularization Investigation (BARI) is the largest of several recent clinical trials that were designed to test the hypothesis that an initial strategy of PTCA in selected patients with multivessel coronary artery disease does not compromise long-term clinical outcome compared with an initial strategy of CABG. This report describes how patients were screened, selected, and recruited in BARI and how this process may influence the results and the interpretation of the trial. During the enrollment period, 25,200 patients undergoing diagnostic coronary angiography at the participating institutions or with off-site angiograms referred to BARI investigators were screened for BARI eligibility. Excluded from screening were patients without coronary artery disease, those with single-vessel disease, prior revascularization, primary congenital, valvular, or myocardial disease, and age >80 years, Slightly more than half of the patients screened (12,670) were not clinically eligible for BARI because of left main disease, insufficient symptoms, emergency revascularization, or other logistic reasons. Thus, 12,530 patients had severe angina and/or ischemia and were clinically eligible for BARI. Nearly 33% of them (4,110) had multivessel disease, which was suitable for both PTCA and CABG. Of the 8,420 patients (67%) who were technically unsuitable, 60% were judged not to be candidates for PTCA, only 3% for CABG, and 3% for both procedures. Nearly half (1,829) of the patients who were clinically and angiographically eligible were randomly assigned to either PTCA (915) or CABG (914). The remaining 2,281 patients did not consent to randomization but 2,013 (88%) agreed to be followed in the eligible, not randomized registry. In addition, a random sample of 422 patients judged to be technically unsuitable for PTCA and/or CABG was enrolled in a registry of angiographic exclusions. Finally, to document ongoing revascularization practice patterns, the BARI investigators have provided semiannual 1-week surveys of all revascularizations at their respective centers as well as a 1-time survey at other institutions in the United States and Canada. Interpretation of the results of the BARI requires understanding the patient population entered into the study. Of the 25,200 patients with multivessel coronary artery disease age <80 years screened for the study, 12,670 were excluded for a variety of reasons (mostly left main disease or insufficient angina to warrant revascularization), and 8,420 were excluded because of technical unsuitability for both procedures. Of the eligible patients, 1,829 were entered into the study and randomized. Nonrandomized patients and a sample of ineligible patients were enrolled into registries. The data from the BARI registries and surveys will be important to put into perspective the relative long-term efficacy and safety of PTCA and CABG in patients who are suitable for both procedures.
C1 UNIV ALABAMA,BIRMINGHAM,AL.
UNIV PITTSBURGH,CTR COORDINATING,PITTSBURGH,PA.
NHLBI,PROGRAM OFF,BETHESDA,MD 20892.
JEWISH HOSP ST LOUIS,ST LOUIS,MO 63110.
NYU,MED CTR,NEW YORK,NY.
ST LOUIS UNIV,MED CTR,ST LOUIS,MO.
UNIV MICHIGAN,MED CTR,ANN ARBOR,MI.
NEW YORK MED COLL,VALHALLA,NY 10595.
MAYO CLIN & MAYO FDN,OFF STUDY CHAIR,ROCHESTER,MN 55905.
RP BOURASSA, MG (reprint author), MONTREAL HEART INST,5000 BELANGER ST E,MONTREAL,PQ H1T 1C8,CANADA.
OI Bourassa, Martial G./0000-0002-4439-8650
NR 11
TC 78
Z9 81
U1 0
U2 0
PU CAHNERS PUBL CO
PI NEW YORK
PA 249 WEST 17 STREET, NEW YORK, NY 10011
SN 0002-9149
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD MAR 23
PY 1995
VL 75
IS 9
BP C3
EP C8
DI 10.1016/S0002-9149(99)80389-0
PG 6
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA QM422
UT WOS:A1995QM42200002
PM 7892820
ER
PT J
AU FRYE, RL
KING, SB
SOPKO, G
DETRE, KM
AF FRYE, RL
KING, SB
SOPKO, G
DETRE, KM
TI A SYMPOSIUM - MULTIVESSEL PTCA VERSUS CABG - BASE-LINE DATA FROM THE
BYPASS ANGIOPLASTY REVASCULARIZATION INVESTIGATION (BARI) AND THE EMORY
ANGIOPLASTY SURGERY TRIAL (EAST) - INTRODUCTION
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Editorial Material
C1 EMORY UNIV HOSP,ATLANTA,GA 30322.
UNIV PITTSBURGH,PITTSBURGH,PA.
NHLBI,BETHESDA,MD 20892.
RP FRYE, RL (reprint author), MAYO CLIN & MAYO FDN,ROCHESTER,MN 55906, USA.
NR 0
TC 5
Z9 5
U1 0
U2 0
PU CAHNERS PUBL CO
PI NEW YORK
PA 249 WEST 17 STREET, NEW YORK, NY 10011
SN 0002-9149
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD MAR 23
PY 1995
VL 75
IS 9
BP C1
EP C2
PG 2
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA QM422
UT WOS:A1995QM42200001
ER
PT J
AU ROGERS, WJ
ALDERMAN, EL
CHAITMAN, BR
DISCIASCIO, G
HORAN, M
LYTLE, B
MOCK, MB
ROSEN, AD
SUTTONTYRRELL, K
WEINER, BH
WHITLOW, PL
AF ROGERS, WJ
ALDERMAN, EL
CHAITMAN, BR
DISCIASCIO, G
HORAN, M
LYTLE, B
MOCK, MB
ROSEN, AD
SUTTONTYRRELL, K
WEINER, BH
WHITLOW, PL
TI BYPASS ANGIOPLASTY REVASCULARIZATION INVESTIGATION (BARI) - BASE-LINE
CLINICAL AND ANGIOGRAPHIC DATA
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
AB This report presents baseline clinical and angiographic data from the Bypass Angioplasty Revascularization Investigation (BARI), a multicenter international trial assessing the relative efficacy of percutaneous transluminal coronary angioplasty (PTCA) versus coronary artery bypass graft surgery (CABG) in selected patients with multivessel coronary artery disease. PTCA is commonly performed in patients with multivessel coronary artery disease, yet its long-term efficacy in comparison to CABG is unknown. From August 1988 through August 1991, 1,829 qualifying patients with multivessel disease suitable for either procedure were randomized to PTCA or CABG; sample size estimates were based on anticipated 5-year mortality. Two registry populations were also defined for follow-up: (1) 2,013 patients eligible for randomization but not randomized; and (2) 422 patients considered by angiography as unsuitable for randomization. Patients randomized in BARI were at relatively high risk for subsequent cardiac events: 39% were greater than or equal to 65 years old, 55% had prior myocardial infarction, 69% presented with unstable angina or non-Q wave myocardial infarction, and 43% had 3-vessel coronary artery disease. Patients randomized to PTCA and CABG were equally matched in all the important baseline variables. The randomized and the eligible but not randomized groups were similar in most respects. However, the nonrandomized group had a higher proportion with college education; fewer with a history of myocardial infarction, heart failure, diabetes, and smoking; and a somewhat better average ejection fraction. At the 3-month follow-up, PTCA had been performed more commonly in the nonrandomized eligible patients, especially those with 2-vessel disease. In comparison to the randomized patients, angiographically excluded patients were older; had more prior myocardial infarctions, heart failure, stable angina, complex coronary anatomy; and were less likely to undergo PTCA. The BARI randomized population is suitably composed to yield a meaningful comparison of the 5-year outcome of patients with multivessel disease eligible for either PTCA or CABG. The registry of eligible, nonrandomized patients and the registry of angiographically excluded patients should provide important ancillary data to complement the randomized trial.
C1 STANFORD UNIV,MED CTR,STANFORD,CA 94305.
VIRGINIA COMMONWEALTH UNIV MED COLL VIRGINIA,RICHMOND,VA.
ST LOUIS UNIV,SCH MED,ST LOUIS,MO.
NIH,BETHESDA,MD 20892.
CLEVELAND CLIN FDN,CLEVELAND,OH 44195.
MAYO CLIN & MAYO FDN,ROCHESTER,MN 55905.
UNIV PITTSBURGH,PITTSBURGH,PA.
UNIV MASSACHUSETTS,WORCESTER,MA 01605.
RP ROGERS, WJ (reprint author), UNIV ALABAMA,MED CTR,334 LHR BLDG,BIRMINGHAM,AL 35294, USA.
NR 11
TC 39
Z9 40
U1 0
U2 2
PU CAHNERS PUBL CO
PI NEW YORK
PA 249 WEST 17 STREET, NEW YORK, NY 10011
SN 0002-9149
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD MAR 23
PY 1995
VL 75
IS 9
BP C9
EP C17
PG 9
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA QM422
UT WOS:A1995QM42200003
PM 7892823
ER
PT J
AU SCHAFF, HV
ROSEN, AD
SHEMIN, RJ
LECLERC, Y
WAREING, TH
AGUIRRE, FV
SOPKO, G
VANDERSALM, TJ
LOOP, FD
AF SCHAFF, HV
ROSEN, AD
SHEMIN, RJ
LECLERC, Y
WAREING, TH
AGUIRRE, FV
SOPKO, G
VANDERSALM, TJ
LOOP, FD
TI CLINICAL AND OPERATIVE CHARACTERISTICS OF PATIENTS RANDOMIZED TO
CORONARY-ARTERY BYPASS-SURGERY IN THE BYPASS ANGIOPLASTY
REVASCULARIZATION INVESTIGATION (BARI)
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID VEIN-GRAFT PATENCY; INTERNAL-MAMMARY-ARTERY; CHRONIC STABLE ANGINA;
MYOCARDIAL-INFARCTION; FOLLOW-UP; SURGICAL THERAPY; UNSTABLE ANGINA;
NATIONAL-HEART; ANGIOGRAPHIC PREDICTORS; ANTIPLATELET THERAPY
AB The surgical cohort of the Bypass Angioplasty Revascularization Investigation (BARI) is the largest group of patients with multivessel coronary artery disease randomly assigned to surgical treatment. This report presents baseline and operative characteristics of the cohort and describes some aspects of the variability in surgical practice among the 14 primary clinical centers and 4 so-investigational sites participating in BARI. Preoperative clinical and angiographic data and intraoperative variables were reviewed in 892 patients who were randomly assigned to coronary artery bypass grafting (CABG) and underwent operation. Associations between patient/lesion variables and operative characteristics are described. Of patients assigned to CABG, 87% underwent an operation within 2 weeks of randomization, as recommended in the protocol. Mean age of the 892 patients was 61 years, and mean age of the 235 women was greater than that of men (64 years vs 60 years); 64% of the surgical patients were classified as having unstable angina during the 6 weeks prior to randomization. Coronary angiography demonstrated 3-vessel disease (50% diameter narrowing by caliper measurement) in 41% of patients, and disease of the left anterior descending coronary artery was present in 87% of patients. A mean of 3.1 coronary arteries per patient were bypassed, and 82% of patients received 1 (70%) or 2 (12%) internal thoracic artery grafts. Prevalence of infernal thoracic grafts was lower in elderly patients (74% of patients greater than or equal to 70 years), in women (72% vs 85% in men; p < 0.01), and in black participants (65%). There was significant center-to-center variation in duration of cardiopulmonary bypass and aortic cross-clamping, methods of intraoperative myocardial protection, and in graft usage. Surgical patients in BARI differ considerably from patients entered into previous randomized trials in that the operative methods and graft usage reflect contemporary practice of coronary artery surgery, although significant variations among institutions were observed.
C1 UNIV PITTSBURGH,CTR COORDINATING,PITTSBURGH,PA.
BOSTON UNIV,MED CTR,BOSTON,MA.
MONTREAL HEART INST,MONTREAL,PQ H1T 1C8,CANADA.
JEWISH HOSP ST LOUIS,ST LOUIS,MO 63110.
ST LOUIS UNIV,MED CTR,ST LOUIS,MO.
NHLBI,BETHESDA,MD 20892.
UNIV MASSACHUSETTS,WORCESTER,MA 01605.
CLEVELAND CLIN FDN,CLEVELAND,OH 44195.
RP SCHAFF, HV (reprint author), MAYO CLIN & MAYO FDN,200 1ST ST SW,ROCHESTER,MN 55905, USA.
NR 73
TC 27
Z9 28
U1 0
U2 0
PU CAHNERS PUBL CO
PI NEW YORK
PA 249 WEST 17 STREET, NEW YORK, NY 10011
SN 0002-9149
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD MAR 23
PY 1995
VL 75
IS 9
BP C18
EP C26
PG 9
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA QM422
UT WOS:A1995QM42200004
PM 7892818
ER
PT J
AU WILLIAMS, DO
BAIM, DS
BATES, E
BONAN, R
BOST, JE
COWLEY, M
FAXON, DP
FEIT, F
JONES, R
KELLETT, MA
KELSEY, SF
SOPKO, G
STADIUS, M
TOPOL, EJ
AF WILLIAMS, DO
BAIM, DS
BATES, E
BONAN, R
BOST, JE
COWLEY, M
FAXON, DP
FEIT, F
JONES, R
KELLETT, MA
KELSEY, SF
SOPKO, G
STADIUS, M
TOPOL, EJ
TI CORONARY ANATOMIC AND PROCEDURAL CHARACTERISTICS OF PATIENTS RANDOMIZED
TO CORONARY ANGIOPLASTY IN THE BYPASS ANGIOPLASTY REVASCULARIZATION
INVESTIGATION (BARI)
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID ARTERY OCCLUSION
AB The Bypass Angioplasty Revascularization Investigation (BARI) is a randomized multicenter clinical trial that compares a strategy of initial coronary angioplasty to initial coronary bypass surgery for patients with multivessel coronary artery disease. The purpose of this report is to describe the coronary anatomic characteristics of the 915 patients assigned to the angioplasty arm of the trial and the manner in which angioplasty was performed. Patients were eligible for BARI if they demonstrated multivessel coronary artery disease, had a clinical indication for revascularization, and were suitable for both coronary angioplasty and bypass surgery. Clinical and technical features of angioplasty procedures were systematically recorded. Coronary cineangiograms obtained before and during the angioplasty were interpreted by a central radiographic laboratory. Angioplasty was performed in 904 (98.8%) of the 915 patients assigned to that initial strategy. Of 6,530 coronary arterial lesions identified, 3,427 (52.5%) were significant (>50% diameter reduction). The majority of patients had 2-6 significant lesions, with 3 being most common. Angioplasty was attempted in 92.2% of the lesions for which it was intended. Lesions most frequently attempted ranged between 50% and 79% in severity. Multilesion angioplasty was performed in 77.5% of patients and 69.7% had multivessel angioplasty. Factors that influenced whether a lesion was attempted included lesion severity, clinical significance, and complexity. For lesions presenting as total occlusions, a history of recent infarction and postinfarction angina favored attempting angioplasty. Patients assigned to the angioplasty arm of BARI had evidence of extensive multilesion and multivessel coronary artery disease. An important component in performing angioplasty in such patients was lesion selection. Lesion morphology and the perceived clinical significance of lesions exerted the greatest influence on lesion selection. Observations of the manner in which angioplasty was performed in BARI provide insight into the contemporary application of angioplasty for patients with multivessel coronary artery disease.
C1 BETH ISRAEL HOSP,BOSTON,MA 02215.
MONTREAL HEART INST,MONTREAL,PQ H1T 1C8,CANADA.
UNIV MICHIGAN,MED CTR,ANN ARBOR,MI.
UNIV PITTSBURGH,CTR COORDINATING,PITTSBURGH,PA.
VIRGINIA MED COLL,RICHMOND,VA.
UNIV BOSTON HOSP,BOSTON,MA 02118.
DUKE UNIV,MED CTR,DURHAM,NC.
BELLEVUE HOSP CTR,NEW YORK,NY 10016.
MAINE MED CTR,PORTLAND,ME 04102.
NHLBI,BETHESDA,MD 20892.
STANFORD UNIV,MED CTR,STANFORD,CA 94305.
CLEVELAND CLIN FDN,CLEVELAND,OH 44195.
RP WILLIAMS, DO (reprint author), BROWN UNIV,RHODE ISL HOSP,DIV CARDIOL,PROVIDENCE,RI 02903, USA.
FU NHLBI NIH HHS [5 U01 HL 38532-07]
NR 9
TC 19
Z9 22
U1 0
U2 1
PU CAHNERS PUBL CO
PI NEW YORK
PA 249 WEST 17 STREET, NEW YORK, NY 10011
SN 0002-9149
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD MAR 23
PY 1995
VL 75
IS 9
BP C27
EP C33
PG 7
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA QM422
UT WOS:A1995QM42200005
PM 7892819
ER
PT J
AU CROOP, CS
AF CROOP, CS
TI MUTATIONS IN BREAST-CANCER
SO CANCER LETTERS
LA English
DT Article; Proceedings Paper
CT 20th Meeting of the International-Association-for-Breast-Cancer-Research
CY SEP 25-28, 1994
CL SENDAI, JAPAN
SP INT ASSOC BREAST CANC RES
DE BREASTS; CANCER; TUMOR SUPPRESSOR GENES; DELETIONS; BRCAI
ID NM23 PROTEIN EXPRESSION; GOOD PROGNOSIS; GENE; CARCINOMAS; TUMORS;
HETEROZYGOSITY; AMPLIFICATION; INT-2; MYC; CHROMOSOME-17Q21
AB The genetics of spontaneous breast cancer is reviewed. We have identified three regions of amplification and nine chromosomal arms with deletions in the genome. The significance and interrelations of these mutations is discussed with respect to the complex genetics of breast carcinoma. Recent work identifying a commonly deleted region between D17S846 and D17S746 is presented, which is approximately 0.5-1.0 Mb centromeric to the newly described BRCA1 gene candidate. Possible explanations for the different locations of our deleted region and the BRCA1 gene are presented.
RP CROOP, CS (reprint author), NCI,TUMOR IMMUNOL & BIOL LAB,BLDG 10,BETHESDA,MD 20892, USA.
NR 45
TC 0
Z9 0
U1 2
U2 3
PU ELSEVIER SCI PUBL IRELAND LTD
PI CLARE
PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE,
IRELAND
SN 0304-3835
J9 CANCER LETT
JI Cancer Lett.
PD MAR 23
PY 1995
VL 90
IS 1
BP 51
EP 56
PG 6
WC Oncology
SC Oncology
GA QU505
UT WOS:A1995QU50500008
ER
PT J
AU GERGEN, P
MCQUILLAN, GM
KIELY, M
EZZATIRICE, TM
SUTTER, RW
VIRELLA, G
AF GERGEN, P
MCQUILLAN, GM
KIELY, M
EZZATIRICE, TM
SUTTER, RW
VIRELLA, G
TI A POPULATION-BASED SEROLOGIC SURVEY OF IMMUNITY TO TETANUS IN THE
UNITED-STATES
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Article
ID DIPHTHERIA IMMUNITY; VACCINATION; CHILDREN; REVACCINATION; IMMUNIZATION;
ADULTS
AB Background. Vaccination rates are frequently considered a surrogate measure of protection. To provide more accurate estimates, serum levels of antibody against tetanus were measured as part of the third National Health and Nutrition Examination Survey (NHANES III), which studied a representative sample of the civilian, noninstitutionalized population of the United States.
Methods. We measured tetanus antitoxin using a solid-phase enzyme immunoassay in serum samples from 10,618 persons six years of age and older who were examined during phase 1 of NHANES III in 1988 to 1991.
Results. Overall, 69.7 percent of Americans six years of age and older had protective levels of tetanus antibodies (>0.15 IU per milliliter). The rate decreased from 87.7 percent among those 6 to 11 years of age to 27.8 percent among those 70 years of age or older, Among children 6 to 16 years of age, 82.2 percent had protective levels of tetanus antibodies, with little variation according to race or ethnicity. More men than women were immune (79.0 percent vs. 62.4 percent). Mexican Americans had a significantly lower rate of immunity (57.9 percent, P<0.05) than either non-Hispanic whites (72.7 percent) or non-Hispanic blacks (68.1 percent). Those with a history of military service, higher levels of education, or incomes above the poverty level were more likely to have protective antibody levels. Although the prevalence of immunity declined rapidly starting at the age of 40 years, most of the 107 cases of tetanus (with 20 deaths) reported in 1989 and 1990 occurred in persons 60 years of age or older,
Conclusions. Despite the fact that effective vaccines against tetanus have been available since the 1940s, many Americans do not have immunity to tetanus, and the rates are lowest among the elderly There is an excellent correlation between vaccination rates (96 percent) and immunity (96 percent) among six-year-olds. However, antibody levels decline over time, and one fifth of older children (10 to 16 years of age) do not have protective antibody levels.
C1 NIAID,BETHESDA,MD 20892.
CTR DIS CONTROL & PREVENT,NATL CTR HLTH STAT,HYATTSVILLE,MD 20782.
US MATERNAL & CHILD HLTH BUR,ROCKVILLE,MD.
CTR DIS CONTROL & PREVENT,NATL IMMUNIZATION PROGRAM,ATLANTA,GA 30333.
MED UNIV S CAROLINA,DEPT MICROBIOL & IMMUNOL,CHARLESTON,SC 29425.
NR 33
TC 208
Z9 211
U1 1
U2 4
PU MASS MEDICAL SOC
PI BOSTON
PA 10 SHATTUCK, BOSTON, MA 02115
SN 0028-4793
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD MAR 23
PY 1995
VL 332
IS 12
BP 761
EP 766
DI 10.1056/NEJM199503233321201
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA QN442
UT WOS:A1995QN44200001
PM 7862178
ER
PT J
AU PERRIENS, JH
STLOUIS, ME
MUKADI, YB
BROWN, C
PRIGNOT, J
POUTHIER, F
PORTAELS, F
WILLAME, JC
MANDALA, JK
KABOTO, M
RYDER, RW
ROSCIGNO, G
PIOT, P
AF PERRIENS, JH
STLOUIS, ME
MUKADI, YB
BROWN, C
PRIGNOT, J
POUTHIER, F
PORTAELS, F
WILLAME, JC
MANDALA, JK
KABOTO, M
RYDER, RW
ROSCIGNO, G
PIOT, P
TI PULMONARY TUBERCULOSIS IN HIV-INFECTED PATIENTS IN ZAIRE - A CONTROLLED
TRIAL OF TREATMENT FOR EITHER 6 OR 12 MONTHS
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Article
ID IMMUNODEFICIENCY-VIRUS INFECTION; HIV-1-INFECTED PATIENTS; CHEMOTHERAPY;
MORTALITY; KINSHASA; KENYA
AB Background. We studied the efficacy of a short-course regimen of chemotherapy for pulmonary tuberculosis in Kinshasa, Zaire. We also assessed whether, among patients with human immunodeficiency virus (HIV) infection, treatment should be extended from 6 to 12 months.
Methods. HIV-seropositive and HIV-seronegative outpatients with pulmonary tuberculosis were treated with rifampin, isoniazid, pyrazinamide, and ethambutol daily for two months, followed by rifampin plus isoniazid twice weekly for four months. The HIV-positive patients who had no evidence of tuberculosis were then randomly assigned to receive either rifampin plus isoniazid or placebo twice weekly for a further six months. We also followed a comparison group of HIV-seronegative patients who received no further treatment for tuberculosis after six months.
Results. After six months, 260 of 335 HIV-seropositive and 186 of 188 HIV-seronegative participants could be evaluated, and their rates of treatment failure were similar: 3.8 and 2.7 percent, respectively. At 24 months, the HIV-seropositive patients who received extended treatment had a relapse rate of 1.9 percent, as compared with 9 percent among the HIV-seropositive patients who received placebo for the second 6 months (P<0.01). Extended treatment did not improve survival, however. Among the HIV-seronegative patients, 5.3 percent relapsed.
Conclusions. Among HIV-seropositive patients with pulmonary tuberculosis, extending treatment from 6 to 12 months reduces the rate of relapse but does not improve survival. The six-month program of partly intermittent antituberculous treatment may be an acceptable alternative when resources are limited.
C1 PROJET SIDA,KINSHASA,ZAIRE.
INST TROP MED,B-2000 ANTWERP,BELGIUM.
BELGIAN AGCY DEV & COOPERAT,BRUSSELS,BELGIUM.
CTR DIS CONTROL & PREVENT,DIV HIV & AIDS,ATLANTA,GA 30341.
NIAID,BETHESDA,MD 20892.
UNIV CATHOLIQUE LOUVAIN,MT GODINNE,BELGIUM.
BUR NATL TB,KINSHASA,ZAIRE.
CTR DEPISTAGE TB,KINSHASA,ZAIRE.
NR 30
TC 225
Z9 229
U1 0
U2 0
PU MASS MEDICAL SOC
PI BOSTON
PA 10 SHATTUCK, BOSTON, MA 02115
SN 0028-4793
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD MAR 23
PY 1995
VL 332
IS 12
BP 779
EP 784
DI 10.1056/NEJM199503233321204
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA QN442
UT WOS:A1995QN44200004
PM 7862181
ER
PT J
AU BARRETT, AJ
POLLOCK, BH
BUCHANAN, GR
AF BARRETT, AJ
POLLOCK, BH
BUCHANAN, GR
TI TREATMENT OF ACUTE LYMPHOBLASTIC-LEUKEMIA IN A 2ND REMISSION - REPLY
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Letter
C1 UNIV FLORIDA,COLL MED,GAINESVILLE,FL 32610.
UNIV TEXAS,SW MED CTR,DALLAS,TX 75235.
RP BARRETT, AJ (reprint author), NIH,BETHESDA,MD 20892, USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MASS MEDICAL SOC
PI BOSTON
PA 10 SHATTUCK, BOSTON, MA 02115
SN 0028-4793
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD MAR 23
PY 1995
VL 332
IS 12
BP 824
EP 824
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA QN442
UT WOS:A1995QN44200028
ER
PT J
AU CARDENAS, AM
KUIJPERS, GAJ
POLLARD, HB
AF CARDENAS, AM
KUIJPERS, GAJ
POLLARD, HB
TI EFFECT OF PROTEIN-SYNTHESIS INHIBITORS ON SYNEXIN LEVELS AND SECRETORY
RESPONSE IN BOVINE ADRENAL-MEDULLARY CHROMAFFIN CELLS
SO BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
LA English
DT Article
DE CHROMAFFIN; SYNEXIN; PROTEIN SYNTHESIS; SECRETION; CYCLOHEXIMIDE;
ACTINOMYCIN D
ID MEMBRANE-FUSION; ANNEXIN-VII; CALCIUM; SYNAPTOTAGMIN; CYCLOHEXIMIDE;
EXPRESSION; GRANULES; RELEASE
AB The effects of the protein synthesis inhibitors actinomycin D and cycloheximide on the cellular content of the calcium binding protein synexin, and on the secretory response of cultured bovine adrenal medullary chromaffin cells were determined. Both protein synthesis inhibitors produced a slow decrease in the cellular synexin content. The synexin level was reduced by 50% after 133 h of incubation in the presence of 2 mu g/ml actinomycin D or 5 mu g/ml cycloheximide. However, this was partly due to an artefactual stabilization of synexin, since metabolic labelling of synexin with [S-35]methionine showed that the half-time of degradation was only 40 h. The secretory response of chromaffin cells was quickly diminished in the presence of protein synthesis inhibitors. Catecholamine secretion induced by membrane depolarization or barium stimulation of intact cells, or by calcium stimulation of digitonin-permeabilized cells was decreased by 77-82% after 24 h of incubation in the presence of 5 mu g/ml cycloheximide. These results suggest that, in addition to synexin, at least one or more proteins with a shorter half-time of degradation than synexin are involved in the secretory response of adrenal chromaffin cells.
C1 NIDDK,CELL BIOL & GENET LAB,BETHESDA,MD 20892.
NR 32
TC 8
Z9 8
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0005-2736
J9 BBA-BIOMEMBRANES
JI Biochim. Biophys. Acta-Biomembr.
PD MAR 22
PY 1995
VL 1234
IS 2
BP 255
EP 260
DI 10.1016/0005-2736(94)00283-U
PG 6
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA QN667
UT WOS:A1995QN66700015
PM 7696302
ER
PT J
AU KHAN, AS
TAYLOR, BR
FILIE, JD
RINGER, DP
KOZAK, CA
AF KHAN, AS
TAYLOR, BR
FILIE, JD
RINGER, DP
KOZAK, CA
TI RAT PHENOL-PREFERRING SULFOTRANSFERASE GENES (STP AND STP2) -
LOCALIZATION TO MOUSE CHROMOSOME-7 AND CHROMOSOME-17
SO GENOMICS
LA English
DT Note
ID COMPLEMENTARY-DNA; N-HYDROXY-2-ACETYLAMINOFLUORENE;
HEPATOCARCINOGENESIS; EXPRESSION; METABOLITE; IV
AB The phenol-preferring sulfotransferases aryl sulfotransferase IV and N-hydroxyarylamine sulfotransferase catalyze sulfate conjugation of N-hydroxy-2-acetylaminofluorene, a metabolite capable of causing hepatocarcinogenesis in rats. We utilized published cDNA sequences of these sulfotransferases to type the progeny of two multilocus crosses and determined that the genes, aryl sulfotransferase (Stp) and N-hydroxyarylamine sulfotransferase (Stp2), map to positions on mouse chromosomes 7 and 17. (C) 1995 Academic Press, Inc.
C1 NIH,BETHESDA,MD 20892.
RP KHAN, AS (reprint author), OKLAHOMA MED RES FDN,NOBEL CTR BIOMED RES,825 NE 13TH ST,MAILSTOP 38,OKLAHOMA CITY,OK 73104, USA.
NR 19
TC 3
Z9 3
U1 0
U2 0
PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
PI SAN DIEGO
PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495
SN 0888-7543
J9 GENOMICS
JI Genomics
PD MAR 20
PY 1995
VL 26
IS 2
BP 417
EP 419
DI 10.1016/0888-7543(95)80233-C
PG 3
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA QR156
UT WOS:A1995QR15600036
PM 7601475
ER
PT J
AU SCIAKY, D
JENKINS, NA
GILBERT, DJ
COPELAND, NG
SONODA, G
TESTA, JR
COHEN, MB
AF SCIAKY, D
JENKINS, NA
GILBERT, DJ
COPELAND, NG
SONODA, G
TESTA, JR
COHEN, MB
TI MAPPING OF GUANYLIN TO MURINE CHROMOSOME-4 AND HUMAN-CHROMOSOME 1P34-P35
SO GENOMICS
LA English
DT Note
ID FLUORESCENCE INSITU HYBRIDIZATION; ENDOGENOUS ACTIVATOR; DNA-SEQUENCES;
MESSENGER-RNA; RAT COLON; MOUSE; CYCLASE; LOCALIZATION; CDNA
C1 CHILDRENS HOSP,MED CTR,DIV PEDIAT GASTROENTEROL & NUTR,CINCINNATI,OH 45229.
UNIV CINCINNATI,CINCINNATI,OH.
NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,MAMMALIAN GENET LAB,FREDERICK,MD.
FOX CHASE CANC CTR,DEPT MED ONCOL,PHILADELPHIA,PA 19111.
OI Cohen, Mitchell/0000-0002-4412-350X
FU NCI NIH HHS [CA-06927, N01-CO-74101, CA-45745]
NR 20
TC 16
Z9 17
U1 0
U2 0
PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
PI SAN DIEGO
PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495
SN 0888-7543
J9 GENOMICS
JI Genomics
PD MAR 20
PY 1995
VL 26
IS 2
BP 427
EP 429
DI 10.1016/0888-7543(95)80238-H
PG 3
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA QR156
UT WOS:A1995QR15600041
PM 7601480
ER
PT J
AU SUKHOV, RR
WALKER, LC
RANCE, NE
PRICE, DL
YOUNG, WS
AF SUKHOV, RR
WALKER, LC
RANCE, NE
PRICE, DL
YOUNG, WS
TI OPIOID PRECURSOR GENE-EXPRESSION IN THE HUMAN HYPOTHALAMUS
SO JOURNAL OF COMPARATIVE NEUROLOGY
LA English
DT Article
DE BASAL FOREBRAIN; DYNORPHIN; ENKEPHALIN; INTERMEDIATE NUCLEUS;
PROOPIOMELANOCORTIN
ID SEXUALLY DIMORPHIC NUCLEUS; MESSENGER-RIBONUCLEIC-ACID; HYPOPHYSEAL
PORTAL BLOOD; CENTRAL NERVOUS-SYSTEM; RHESUS-MONKEY BRAIN;
LUTEINIZING-HORMONE SECRETION; MEDIAL BASAL HYPOTHALAMUS;
BETA-NEO-ENDORPHIN; RAT-BRAIN; INSITU HYBRIDIZATION
AB Using in situ hybridization histochemistry, we studied the distribution of neurons that express preproopiomelanocortin (pre-POMC), preprodynorphin (pre-PDYN), and preproenkephalin (pre-PENK) gene transcripts within the human hypothalamus and surrounding structures. Of the three opioid systems, pre-POMC neurons have the most restricted distribution. Pre-POMC cells are most numerous in the infundibular nucleus and retrochiasmatic area of the mediobasal hypothalamus; a few labeled cells are present within the boundaries of the ventromedial nucleus and infundibular stalk. Pre-POMC message was not found in the limited samples of structures adjacent to the hypothalamus.
In contrast to neurons that express pre-POMC, neurons expressing pre-PDYN and pre-PENK are more widely represented throughout the hypothalamus and extrahypothalamic structures. However, pre-PDYN and pre-PENK cells differ from one another in distribution. Pre-PDYN message is especially abundant in neurons of the tuberal and mammillary regions, with a distinct population of labeled cells in the premammillary nucleus and dorsal posterior hypothalamus. Pre-PDYN gene expression also is found in neurons of the dorsomedial nucleus, ventromedial nucleus, caudal magnocellular portion of the paraventricular nucleus, dorsolateral supraoptic nucleus, tuberomammillary nucleus, caudal lateral hypothalamus, and retrochiasmatic area. In structures immediately adjacent to the hypothalamus, pre-PDYN neurons were observed in the caudate nucleus, putamen, cortical nucleus of the amygdala, and bed nucleus of the stria terminalis.
Pre-PENK neurons occur in varying numbers in all hypothalamic nuclei except the mammillary bodies. The chiasmatic region is particularly rich in pre-PENK neurons, with the highest packing density in the intermediate nucleus [the intermediate nucleus (Braak and Braak [1987] Anat. Embryol. 176:315-330) has also been termed the sexually dimorphic nucleus of the preoptic area (SDA-POA; Swaab and Fliers [1985] Science 228:1112-1115) or the interstitial nucleus of the anterior hypothalamus 1 (Allen et al. [1989] J. Neurosci. 9:497-506)], dorsal suprachiasmatic nucleus, medial preoptic area, and rostral lateral hypothalamic area. Pre-PENK neurons are numerous in the infundibular nucleus, ventromedial nucleus, dorsomedial nucleus, caudal parvicellular portion of the paraventricular nucleus, tuberomammillary nucleus, lateral hypothalamus, and retrochiasmatic area. Only a few lightly labeled cells were found in the periphery of the supraoptic nucleus and lateral tuberal nucleus. In areas adjacent to the hypothalamus, cells that contain pre-PENK message occur in the nucleus basalis of Meynert, central nucleus of amygdala, bed nucleus of the stria terminalis, caudate nucleus, and putamen. The differential distribution of pre-POMC, pre-PDYN, and pre-PENK neurons in the human hypothalamus suggests that these three opioid systems influence hypothalamic functions in quite different ways. (C) 1995 Wiley-Liss, Inc.
C1 JOHNS HOPKINS UNIV,SCH MED,DEPT PATHOL,BALTIMORE,MD 21205.
JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL,BALTIMORE,MD 21205.
JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21205.
JOHNS HOPKINS UNIV,DEPT PSYCHOL,BALTIMORE,MD 21218.
UNIV ARIZONA,COLL MED,DEPT PATHOL,TUCSON,AZ 85724.
UNIV ARIZONA,COLL MED,DEPT NEUROL,TUCSON,AZ 85724.
UNIV ARIZONA,COLL MED,DEPT ANAT,TUCSON,AZ 85724.
NIMH,CELL BIOL LAB,BETHESDA,MD 20892.
RP SUKHOV, RR (reprint author), JOHNS HOPKINS UNIV,SCH MED,NEUROPATHOL LAB,558 ROSS RES BLDG,720 RUTLAND AVE,BALTIMORE,MD 21205, USA.
RI Young, W Scott/A-9333-2009; Walker, L/J-6541-2015
OI Young, W Scott/0000-0001-6614-5112; Walker, L/0000-0001-9166-3261
FU NINDS NIH HHS [NS 20471, NS AG 05146, NS07179]
NR 141
TC 35
Z9 36
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0021-9967
J9 J COMP NEUROL
JI J. Comp. Neurol.
PD MAR 20
PY 1995
VL 353
IS 4
BP 604
EP 622
DI 10.1002/cne.903530410
PG 19
WC Neurosciences; Zoology
SC Neurosciences & Neurology; Zoology
GA QJ296
UT WOS:A1995QJ29600009
PM 7759618
ER
PT J
AU PANTALEO, G
EMBRETSON, J
AF PANTALEO, G
EMBRETSON, J
TI HOT PAPERS - AIDS RESEARCH - MASSIVE COVERT INFECTION OF HELPER
T-LYMPHOCYTES AND MICROPHAGES BY HIV DURING INCUBATION PERIOD OF AIDS BY
EMBRETSON,J., ZUPANCIC,M., RIBAS,J.L., BURKE,A., RACZ,P., TENNERRACZ,K.,
HAASE,A.T.
SO SCIENTIST
LA English
DT Editorial Material
C1 SCHWEGMAN LUNDBERG & WOESSNER PA,MINNEAPOLIS,MN.
RP PANTALEO, G (reprint author), NIAID,BETHESDA,MD 20892, USA.
RI Pantaleo, Giuseppe/K-6163-2016
NR 1
TC 0
Z9 0
U1 0
U2 2
PU SCIENTIST INC
PI PHILADELPHIA
PA 3600 MARKET ST SUITE 450, PHILADELPHIA, PA 19104
SN 0890-3670
J9 SCIENTIST
JI Scientist
PD MAR 20
PY 1995
VL 9
IS 6
BP 15
EP 15
PG 1
WC Information Science & Library Science; Multidisciplinary Sciences
SC Information Science & Library Science; Science & Technology - Other
Topics
GA QM423
UT WOS:A1995QM42300016
ER
PT J
AU PANTALEO, G
EMBRESTSON, J
AF PANTALEO, G
EMBRESTSON, J
TI HOT PAPERS - AIDS RESEARCH - HIV-INFECTION IS ACTIVE AND PROGRESSIVE IN
LYMPHOID-TISSUE DURING THE CLINICALLY LATENT STAGE OF DISEASE BY
PANTALEO,G., GRAZIOSI,C., DEMAREST,J.M., BUTINI,L., MONTRONI,M.,
FOX,C.H., ORENSTEIN,J.M., KOTLER,D.P., FAUCI,A.S.
SO SCIENTIST
LA English
DT Editorial Material
C1 SCHWEGMAN LUNDBERG & WOESSNER PA,MINNEAPOLIS,MN.
RP PANTALEO, G (reprint author), NIAID,BETHESDA,MD 20892, USA.
RI Pantaleo, Giuseppe/K-6163-2016
NR 1
TC 0
Z9 0
U1 0
U2 2
PU SCIENTIST INC
PI PHILADELPHIA
PA 3600 MARKET ST SUITE 450, PHILADELPHIA, PA 19104
SN 0890-3670
J9 SCIENTIST
JI Scientist
PD MAR 20
PY 1995
VL 9
IS 6
BP 15
EP 15
PG 1
WC Information Science & Library Science; Multidisciplinary Sciences
SC Information Science & Library Science; Science & Technology - Other
Topics
GA QM423
UT WOS:A1995QM42300015
ER
PT J
AU ROMANOV, VI
WRATHALL, LS
SIMMONS, TD
DASILVA, PP
SOBEL, ME
AF ROMANOV, VI
WRATHALL, LS
SIMMONS, TD
DASILVA, PP
SOBEL, ME
TI PROTEIN-SYNTHESIS IS REQUIRED FOR LAMININ-INDUCED EXPRESSION OF THE
67-KDA LAMININ RECEPTOR AND ITS 37-KDA PRECURSOR
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
ID TUMOR INVASION; METASTASIS
AB The high affinity 67-kDa laminin receptor (67LR) is highly expressed in metastatically active human cancers. A 37 - kDa polypeptide has been identified as its precursor (37LRP). Antibodies raised against 37LRP-derived synthetic peptides were used in immunogold electron microscopy and immunoblot studies to assess the effect of laminin on expression of the 67LR and the 37LRP. Laminin (15 mu g/ml) treatment of suspended A2058 human melanoma cells doubled the expression of both 37LRP and the 67LR. Fibronectin had no effect. There was no effect of laminin on the expression of actin or galectin-3. Cycloheximide treatment. of cells prior to laminin abrogated its inducible effect. The results suggest that binding of laminin by cell surface laminin receptors induces synthesis of the 37LRP and mature 67LR, with a consequent delivery to the cell surface of more laminin binding proteins for potentiated attachment of the melanoma cell to the basement membrane during invasion and metastasis.
C1 NCI,MOLEC PATHOL SECT,BETHESDA,MD 20892.
NCI,FREDERICK CANC RES & DEV CTR,MEMBRANE BIOL SECT,FREDERICK,MD 21702.
NR 12
TC 20
Z9 20
U1 0
U2 2
PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
PI SAN DIEGO
PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495
SN 0006-291X
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD MAR 17
PY 1995
VL 208
IS 2
BP 637
EP 643
DI 10.1006/bbrc.1995.1386
PG 7
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA QM952
UT WOS:A1995QM95200027
PM 7695618
ER
PT J
AU ROSENBERG, HF
MORRISON, RP
LI, F
AF ROSENBERG, HF
MORRISON, RP
LI, F
TI IDENTIFICATION OF A 40-KDA HUMAN PROTEIN THAT CROSS-REACTS WITH
PROKARYOTIC HSP60 CHAPERONINS
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
ID HEAT-SHOCK PROTEIN; RHEUMATOID-ARTHRITIS; ESCHERICHIA-COLI; STRESS
PROTEINS; MYCOBACTERIUM-TUBERCULOSIS; NUCLEOTIDE-SEQUENCE;
ANTIBODY-LEVELS; GENE; ANTIGEN; CELL
AB Cross-reactivity between the immunodominant bacterial hsp60 proteins and heterologous human target proteins has led to numerous hypotheses on the role of hsp60 in the pathogenesis of autoimmune disease. In this work, we describe a novel 40-kDa human protein that crossreacts with bacterial hsp60 proteins. CCP40 (chaperone cross-reacting protein, 40-kDa) was identified in extracts from HL-60 (human promyelocytic leukemia) cells on Western blots probed with A57-E4, a monoclonal antibody specifying a linear polypeptide epitope common among the bacterial hsp60 proteins (Yuan et. al. (1992) Inf. Immun. 60, 2288-2296). CCP40 was detected in other human hematopoietic cell lines, but could not be detected in mature peripheral blood leukocytes. CCP40 was also expressed in human CD34+ peripheral blood progenitor cells, disappearing with cytokine-induced cellular maturation. (C) 1995 Academic Press. Inc.
C1 NIAID,ROCKY MT LABS,INTRACELLULAR PARASITES LAB,HAMILTON,MT 59840.
RP ROSENBERG, HF (reprint author), NIAID,HOST DEF LAB,BETHESDA,MD 20892, USA.
NR 34
TC 1
Z9 1
U1 0
U2 0
PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
PI SAN DIEGO
PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495
SN 0006-291X
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD MAR 17
PY 1995
VL 208
IS 2
BP 697
EP 703
DI 10.1006/bbrc.1995.1394
PG 7
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA QM952
UT WOS:A1995QM95200035
PM 7695625
ER
PT J
AU AHMED, AH
JACOBSON, KA
KIM, JH
HEPPEL, LA
AF AHMED, AH
JACOBSON, KA
KIM, JH
HEPPEL, LA
TI PRESENCE OF BOTH A(1) AND A(2A) ADENOSINE RECEPTORS IN HUMAN-CELLS AND
THEIR INTERACTION
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
ID BETA-GAMMA-SUBUNITS; ADENYLYL CYCLASE; PERTUSSIS TOXIN; DNA-SYNTHESIS;
RAT-BRAIN; PROTEIN; STIMULATION; BINDING
AB We have obtained pharmacological evidence for the expression of both A(1)- (inhibitory) and A(2a)- (stimulatory) adenosine receptors in cultured human foreskin fibroblasts and lung fibroblasts. The Al receptors were sufficiently abundant in foreskin fibroblasts so that binding studies with a radioactively labeled specific ligand confirmed their existence. Both receptors were activated during the stimulation of cAMP accumulation and DNA synthesis by adenosine. (C) 1995 Academic Press, Inc.
C1 NIDDK,CHEM LAB,BETHESDA,MD 20892.
RP AHMED, AH (reprint author), CORNELL UNIV,BIOCHEM MOLEC & CELL BIOL SECT,ITHACA,NY 14853, USA.
RI Jacobson, Kenneth/A-1530-2009
OI Jacobson, Kenneth/0000-0001-8104-1493
FU Intramural NIH HHS [Z01 DK031117-20, Z99 DK999999]; NCI NIH HHS [5 RO1
CA58518]
NR 17
TC 13
Z9 13
U1 0
U2 0
PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
PI SAN DIEGO
PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495
SN 0006-291X
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD MAR 17
PY 1995
VL 208
IS 2
BP 871
EP 878
DI 10.1006/bbrc.1995.1416
PG 8
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA QM952
UT WOS:A1995QM95200057
PM 7695645
ER
PT J
AU ZHANG, LX
MILLS, KJ
DAWSON, MI
COLLINS, SJ
JETTEN, AM
AF ZHANG, LX
MILLS, KJ
DAWSON, MI
COLLINS, SJ
JETTEN, AM
TI EVIDENCE FOR THE INVOLVEMENT OF RETINOIC ACID RECEPTOR
RAR-ALPHA-DEPENDENT SIGNALING PATHWAY IN THE INDUCTION OF TISSUE
TRANSGLUTAMINASE AND APOPTOSIS BY RETINOIDS
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID HUMAN NEUROBLASTOMA-CELLS; LUNG-CARCINOMA CELLS; GENE-EXPRESSION;
NUCLEAR RECEPTORS; EPIDERMAL-CELLS; HL-60 CELLS; DEATH; RXR;
DIFFERENTIATION; IDENTIFICATION
AB In this study, we show that all-trans-retinoic acid (RA) is a potent inducer of tissue transglutaminase (TGase II) and apoptosis in the rat tracheobronchial epithelial cell line SPOC-1. We demonstrate that these cells express the retinoid receptors RAR alpha, RAR gamma, and RXR beta. To identify which of these receptors are involved in regulating these processes, we analyzed the effects of several receptor-selective agonists, an antagonist, and a dominant-negative RAR alpha. We show that the RAR-selective retinoid SRI-6751-84 strongly increased TGase II expression at both the protein and mRNA levels, whereas the RXR-selective retinoid SR11217 had little effect. The RAR alpha-selective retinoid Ro40-6055 was also able to induce TGase II, whereas the RAR gamma-selective retinoid CD437 was inactive. The induction of TGase II by the RAR-selective retinoid was completely inhibited by the RAR alpha-antagonist Ro41-5253. Overexpression of a truncated RAR alpha gene with dominant-negative activity also inhibited the induction of TGase II expression. The increase in TGase II is associated with an induction of apoptosis as revealed by DNA fragmentation and the generation of apoptotic cells. We demonstrate that apoptosis is affected by retinoids in a manner similar to TGase II. Our results suggest that the induction of TGase II expression and apoptosis in SPOC-1 cells are mediated through an RAR alpha-dependent signaling pathway.
C1 NIEHS,PULM PATHOBIOL LAB,CELL BIOL SECT,RES TRIANGLE PK,NC 27709.
SRI INT,BIOORGAN CHEM LAB,MENLO PK,CA 94025.
FRED HUTCHINSON CANC RES CTR,PROGRAM MOLEC MED,SEATTLE,WA 98104.
OI Jetten, Anton/0000-0003-0954-4445
FU NCI NIH HHS [CA-55397]
NR 54
TC 128
Z9 132
U1 0
U2 1
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 17
PY 1995
VL 270
IS 11
BP 6022
EP 6029
PG 8
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QM945
UT WOS:A1995QM94500049
PM 7890733
ER
PT J
AU HUH, HY
LO, SK
YESNER, LM
SILVERSTEIN, RL
AF HUH, HY
LO, SK
YESNER, LM
SILVERSTEIN, RL
TI CD36 INDUCTION ON HUMAN MONOCYTES UPON ADHESION TO TUMOR NECROSIS
FACTOR-ACTIVATED ENDOTHELIAL-CELLS
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID GENE-EXPRESSION; GLYCOPROTEIN-IV; MELANOMA-CELLS; GROWTH-FACTOR;
RECEPTOR; IDENTIFICATION; SPECIFICITY; RECOGNITION; NEUTROPHILS; BINDING
AB Cell adhesion between circulating monocytes and the endothelium is a critical component of vascular thromboregulation and atherogenesis. The biochemical and genetic consequences of adhesion are poorly understood, We have found that monocyte surface expression of CD36, an integral membrane receptor for thrombospondin, collagen, and oxidized low density lipoprotein, increased dramatically upon adhesion to tumor necrosis factor-activated human umbilical vein endothelial cells (HUVEC), Expression was assessed by indirect immunofluorescence microscopy and immunoblotting using monoclonal antibodies to CD36, Steady-state CD36 mRNA levels, detected by RNase protection assay, also showed a similar pattern of up-regulation, To verify the adhesion dependence of the observed phenomenon, monocytes were co-cultured with tumor necrosis factor-activated HUVEC in a transwell apparatus that physically separated monocytes from the endothelial cells, Under these conditions, no increase in CD36 expression was detected, demonstrating that the enhanced monocyte CD36 expression observed is not due to soluble factors released by HUVEC, To characterize the specific adhesion molecules involved in the process, co culture assays were performed on murine L cells transfected with either human E-selectin or intercellular adhesion molecule-1 cDNAs, A dramatic increase in CD36 mRNA was seen upon monocyte adhesion to E-selectin-transfected L cells compared with adhesion to intercellular adhesion molecule-1 or control transfectants, Furthermore, monoclonal antibodies to E-selectin inhibited the adhesion-dependent up-regulation of CD36 mRNA induced by transfected L cells or cytokine-activated endothelial cells, These findings demonstrate adhesion-dependent gene regulation of monocyte CD36 and suggest the possible involvement of E-selectin in initiating this process.
C1 CORNELL UNIV,COLL MED,DEPT MED,DIV HEMATOL & ONCOL,NEW YORK,NY 10021.
CORNELL UNIV,COLL MED,CELL BIOL & GENET PROGRAM,NEW YORK,NY 10021.
CORNELL UNIV,COLL MED,NATL INST HLTH,SPECIALIZED CTR RES THROMBOSIS,NEW YORK,NY 10021.
FU NHLBI NIH HHS [HL 18828, HL 46403, HL 42540]
NR 22
TC 46
Z9 47
U1 0
U2 1
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 17
PY 1995
VL 270
IS 11
BP 6267
EP 6271
PG 5
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QM945
UT WOS:A1995QM94500083
PM 7534309
ER
PT J
AU RUVINOV, SB
YANG, XJ
PARRIS, KD
BANIK, U
AHMED, SA
MILES, EW
SACKETT, DL
AF RUVINOV, SB
YANG, XJ
PARRIS, KD
BANIK, U
AHMED, SA
MILES, EW
SACKETT, DL
TI LIGAND-MEDIATED CHANGES IN THE TRYPTOPHAN SYNTHASE INDOLE TUNNEL PROBED
BY NILE-RED FLUORESCENCE WITH WILD-TYPE, MUTANT, AND CHEMICALLY-MODIFIED
ENZYMES
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID SITE-SPECIFIC MUTAGENESIS; ESCHERICHIA-COLI; ALPHA-SUBUNIT;
BETA-SUBUNIT; SALMONELLA-TYPHIMURIUM; BIENZYME COMPLEX; ALPHA-2-BETA-2
COMPLEX; FLEXIBLE LOOP; CONFORMATIONAL-CHANGES; ENZYMATIC-ACTIVITIES
AB The bacterial tryptophan synthase alpha(2) beta(2) complex contains an unusual structural feature: an intramolecular tunnel that channels indole from the active site of the alpha subunit to the active site of the beta subunit 25 Angstrom A away, Here we investigate the role of the tunnel in communication between the alpha and beta subunits using the polarity-sensitive fluorescent probe, Nile Red. Interaction of Nile Red in the nonpolar tunnel near beta subunit residues Cys-170 and Phe-280 is supported by studies with enzymes altered at these positions. Restricting the tunnel by enlarging Cys-170 by chemical modification or mutagenesis decreases the fluorescence of Nile Red by 30-70%. Removal of a partial restriction in the tunnel by replacing Phe-280 by Cys or Ser increases the fluorescence of Nile Red more than 2-fold. A binding site for Nile Red in this region near the pyridoxal phosphate coenzyme of the beta subunit is further supported by iodide quenching and fluorescence energy transfer experiments and by molecular modeling based on the three-dimensional structure of the alpha(2) beta(2) complex. Finally, studies using Nile Red as a sensitive probe of conformational changes in the tunnel reveal that allosteric ligands (alpha subunit) or active site ligands (beta subunit) decrease the fluorescence of Nile Red. We speculate that allosteric and active site ligands induce a tunnel restriction near Phe-280 that serves as a gate to control passage of indole through the tunnel.
C1 NIH, NIDDK, BIOCHEM PHARMACOL LAB, BETHESDA, MD 20892 USA.
NIH, NIDDK, MOLEC BIOL LAB, BETHESDA, MD 20892 USA.
NR 63
TC 51
Z9 52
U1 0
U2 4
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0021-9258
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 17
PY 1995
VL 270
IS 11
BP 6357
EP 6369
PG 13
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QM945
UT WOS:A1995QM94500096
PM 7890774
ER
PT J
AU BONNER, JC
BADGETT, A
HOFFMAN, M
LINDROOS, PM
AF BONNER, JC
BADGETT, A
HOFFMAN, M
LINDROOS, PM
TI INHIBITION OF PLATELET-DERIVED GROWTH FACTOR-BB-INDUCED FIBROBLAST
PROLIFERATION BY PLASMIN-ACTIVATED ALPHA(2)-MACROGLOBULIN IS MEDIATED
VIA AN ALPHA(2)-MACROGLOBULIN RECEPTOR LOW-DENSITY-LIPOPROTEIN
RECEPTOR-RELATED PROTEIN-DEPENDENT MECHANISM
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID IDIOPATHIC PULMONARY FIBROSIS; RAT LUNG FIBROBLASTS; SMOOTH-MUSCLE
CELLS; ALPHA-2-MACROGLOBULIN RECEPTOR; ALPHA-MACROGLOBULIN; FACTOR PDGF;
ALVEOLAR MACROPHAGES; CYTOKINE BINDING; GENE-EXPRESSION; FACTOR-BETA
AB alpha(2)-Macroglobulin (alpha(2)M) is a potentially important regulator of platelet-derived growth factor-BB (PDGF-BB)stimulated cell growth due to our previous observation that PDGF-BB binds to alpha(2)M noncovalently (Bonner, J. C., Goodell, A. L., Lasky, J. A., and Hoffman, M. R. (1992) J. Biol. Chem. 267, 12837-12844). We examined the in vitro effect of native and plasmin activated (receptor-recognized) alpha(2)M on the PDGF-BB-induced proliferation of mouse Swiss 3T3 and rat lung fibroblasts. Nondenaturing polyacrylamide gel electrophoresis showed that plasmin converted alpha(2)M to its electrophoretically ''fast'' form at a 2:1 molar ratio and that I-125-PDGF-BB bound both alpha(2)M and alpha(2)M-plasmin. PDGF-BB-induced growth was not affected by native alpha(2)M (0.3 mu M) or plasmin (0.6 mu M). The combination of plasmin and alpha(2)M (2:1 molar ratio) inhibited PDGF-BB induced cell proliferation 80-90%. Complexes of PDGF-BB .alpha(2)M purified by gel filtra tion chromatography retained growth promoting activity, but the PDGF-BB .alpha(2)M-plasmin complex did not, Preincubation of fibroblasts (37 degrees C for 24 h) with alpha(2)M-plasmin did not change I-125-PDGF BB binding or affect gene expression of the 6.5 kilobase PDGF-alpha receptor or 5.2-kilobase PDGF-beta receptor mRNA However, preincubation with alpha(2)M-plasmin (0-4 degrees C for 4 h) increased I-125-PDGF-BB binding a fold, and this increase was blocked by a receptor-associated protein antagonist of the alpha(2)M-receptor/low density lipoprotein receptor-related protein, The receptor-associated protein antagonist blocked I-125-alpha(2)M-methylamine binding, inhibited PDGF-BB-alpha(2)M-plasmin uptake from fibroblast-cultured supernatants, and abolished the inhibitory effect of alpha(2)M-plasmin on PDGF-stimulated growth, These data suggest that inhibition of PDGF-stimulated proliferation by alpha(2)M-plasmin is mediated in part by clearance of PDGF-BB-alpha(2)M-plasmin through the lipoprotein receptor-related protein.
C1 DUKE UNIV,MED CTR,DURHAM VET AFFAIRS MED CTR,DEPT PATHOL,SERV LAB,DURHAM,NC 27705.
RP BONNER, JC (reprint author), NIEHS,PULM PATHOBIOL LAB,POB 12233,RES TRIANGLE PK,NC 27709, USA.
NR 60
TC 24
Z9 24
U1 0
U2 0
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 17
PY 1995
VL 270
IS 11
BP 6389
EP 6395
PG 7
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QM945
UT WOS:A1995QM94500099
PM 7534312
ER
PT J
AU XU, ZQ
QIU, YL
CHOKEKIJCHAI, S
MITSUYA, H
ZEMLICKA, J
AF XU, ZQ
QIU, YL
CHOKEKIJCHAI, S
MITSUYA, H
ZEMLICKA, J
TI UNSATURATED ACYCLIC ANALOGS OF 2'-DEOXYADENOSINE AND THYMIDINE
CONTAINING FLUORINE - SYNTHESIS AND BIOLOGICAL-ACTIVITY
SO JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Article
ID PROTECTED ALPHA-FLUOROGLYCINES; NUCLEOSIDE ANALOGS; ANTIVIRAL ACTIVITY;
HYDROGENATION; REPLICATION; ACIDS
AB The syntheses and biological activities of fluorobutynol 11 and (E)- and (Z)-fluorobutenols 8a,d and 9a,d are described. Alkylation of adenine with bromofluorobutyne 13a afforded intermediate 14 which was converted to fluorobutynol 11. Aldehyde 16a and (carbothoxyfluoromethyl)triphenylphosphonium bromide furnished (E)- and (Z)-fluorobutenoates 19a and 20a accompanied by regioisomer 21a. A similar reaction of compound 16d afforded Z- and E-esters 19d and 20d. Reduction of the mixture of 19a and 20a with DIBALH gave (E)- and (Z)-fluoroalkenols 8a and 9a. Similarly, the Z-ester 19d gave (Z)-fluoroalkenol 9d. Both 19d and 20d were reduced with NaBH4 to give (Z)- and (E)-fluoroalkenols 9d and 8d. Hydrogenation of 19a and 20a afforded fluoro ester 23. A similar reduction of 8a and 9a led to fluoro alcohol 24 and the defluorinated product 25 which were separated by chromatography on a Bio-Rad AG 1-X2 (OH-) column. (Z)-Fluorobutenol 9a is a substrate for adenosine deaminase, whereas the E-isomer 8a is inert toward the enzyme. By contrast, analogue 8a inhibited the replication and cytopathic effect of HN-1 in ATH8 cells with an IC50 Of approximately 100 mu M, but the Z-isomer 9a was inactive. This effect was accompanied by 36% cytotoxicity at 100 mu M. Compounds 11 and 8d inhibited the growth of murine leukemia L1210 culture with IC50 = 89 and 60 mu M, respectively.
C1 MICHIGAN CANC FDN,DEPT CHEM,DETROIT,MI 48201.
WAYNE STATE UNIV,SCH MED,DEPT INTERNAL MED,DETROIT,MI 48201.
WAYNE STATE UNIV,SCH MED,DEPT BIOCHEM,DETROIT,MI 48201.
NCI,MED BRANCH,EXPTL RETROVIROL SECT,BETHESDA,MD 20892.
FU NCI NIH HHS [CA32779]
NR 36
TC 17
Z9 17
U1 0
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA PO BOX 57136, WASHINGTON, DC 20037-0136
SN 0022-2623
J9 J MED CHEM
JI J. Med. Chem.
PD MAR 17
PY 1995
VL 38
IS 6
BP 875
EP 882
DI 10.1021/jm00006a004
PG 8
WC Chemistry, Medicinal
SC Pharmacology & Pharmacy
GA QN521
UT WOS:A1995QN52100004
PM 7699702
ER
PT J
AU RAGHAVAN, K
BUOLAMWINI, JK
FESEN, MR
POMMIER, Y
KOHN, KW
WEINSTEIN, JN
AF RAGHAVAN, K
BUOLAMWINI, JK
FESEN, MR
POMMIER, Y
KOHN, KW
WEINSTEIN, JN
TI 3-DIMENSIONAL QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP (QSAR) OF HIV
INTEGRASE INHIBITORS - A COMPARATIVE MOLECULAR-FIELD ANALYSIS (COMFA)
STUDY
SO JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Article
ID DNA INTEGRATION; RETROVIRAL DNA; BINDING; VALIDATION; PREDICTION;
RECEPTORS
AB We present the results from a comparative molecular field analysis (CoMFA) of a set of flavone analogs that inhibit HIV-1 integrase-mediated cleavage (3'-processing step) and integration (strand transfer step) in vitro. The results indicate a strong correlation between the inhibitory activity of these flavones and the steric and electrostatic fields around them. CoMFA quantitative structure-activity relationship models with considerable predictive ability (cross-validated r(2) as high as 0.8) were obtained.
C1 NCI, DEV THERAPEUT PROGRAM, MOLEC PHARMACOL LAB, DIV CANC TREATMENT, BETHESDA, MD 20892 USA.
NR 30
TC 93
Z9 95
U1 0
U2 1
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0022-2623
EI 1520-4804
J9 J MED CHEM
JI J. Med. Chem.
PD MAR 17
PY 1995
VL 38
IS 6
BP 890
EP 897
DI 10.1021/jm00006a006
PG 8
WC Chemistry, Medicinal
SC Pharmacology & Pharmacy
GA QN521
UT WOS:A1995QN52100006
PM 7699704
ER
PT J
AU PRASAD, JVN
PARA, KS
TUMMINO, PJ
FERGUSON, D
MCQUADE, TJ
LUNNEY, EA
RAPUNDALO, ST
BATLEY, BL
HINGORANI, G
DOMAGALA, JM
GRACHECK, SJ
BHAT, TN
LIU, BS
BALDWIN, ET
ERICKSON, JW
SAWYER, TK
AF PRASAD, JVN
PARA, KS
TUMMINO, PJ
FERGUSON, D
MCQUADE, TJ
LUNNEY, EA
RAPUNDALO, ST
BATLEY, BL
HINGORANI, G
DOMAGALA, JM
GRACHECK, SJ
BHAT, TN
LIU, BS
BALDWIN, ET
ERICKSON, JW
SAWYER, TK
TI NONPEPTIDIC POTENT HIV-1 PROTEASE INHIBITORS -
(4-HYDROXY-6-PHENYL-2-OXO-2H-PYRAN-3-YL)THIOMETHANES THAT SPAN P-1-P-2'
SUBSITES IN A UNIQUE MODE OF ACTIVE-SITE BINDING
SO JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Article
ID HUMAN-IMMUNODEFICIENCY-VIRUS; DIPEPTIDE ISOSTERES; DESIGN; PROTEINASE;
AIDS; ACID
AB Using molecular modeling and the information derived from the X-ray crystal structure of HIV-1 protease (HIV PR) complexed with the pyran-2-one 1, a series of (4-hydroxy-6-phenyl-2-oxo-2H-pyran-3-yl)thiomethanes was designed and analyzed as novel, nonpeptidic inhibitors of HIV PR. Structure-activity studies led to the discovery of inhibitor 19 having (RS)-1-(cyclopentylthio)-3-methylbutyl functionalization at the C-3 position, which exhibited a K-c of 33 nM. A X-ray crystallographic structure of 19 bound to HIV PR showed that structural water-301 (inhibitor-flap-bridging water) was displaced by the inhibitor. Interestingly, the enol moiety of the pyran-2-one formed a hydrogen bond directly with Asp125 and with Asp25 via a bridging water molecule, thus illustrating a unique mode of active site binding by an HIV PR inhibitor. The pendant cyclopentyl and isobutyl groups of 19 occupied the S-1' and S-2' binding sites, respectively, whereas the 6-phenyl group occupied a region in between the S-1 and S-3 pockets of HIV PR. Selected compounds were tested for antiviral activity on H9 cells infected with HIV-1(IIIb). A correlation between enzymatic activity and antiviral activity was not found in this series. The best antiviral compound in this series, 18, contained (RS)-3-[cyclopentyl(cyclopentylthio )methyl] functionalization at the C-3 position of the pyran-2-one ring and exhibited a CIC50 of 14 mu M and TC50 of 70 mu M. These studies demonstrate that potent enzyme inhibition can be achieved by inhibitors that span only three subsites.
C1 WARNER LAMBERT PARKE DAVIS, PARKE DAVIS PHARMACEUT RES DIV, DEPT BIOCHEM, ANN ARBOR, MI 48106 USA.
WARNER LAMBERT PARKE DAVIS, PARKE DAVIS PHARMACEUT RES DIV, DEPT INFECT DIS, ANN ARBOR, MI 48106 USA.
WARNER LAMBERT PARKE DAVIS, PARKE DAVIS PHARMACEUT RES DIV, DEPT CARDIOVASC THERAPEUT, ANN ARBOR, MI 48106 USA.
PRI DYNCORP, NCI, FREDERICK CANC RES & DEV CTR, STRUCT BIOCHEM PROGRAM, FREDERICK, MD 21702 USA.
RP PRASAD, JVN (reprint author), WARNER LAMBERT PARKE DAVIS, PARKE DAVIS PHARMACEUT RES DIV, DEPT CHEM, 2800 PLYMOUTH RD, ANN ARBOR, MI 48106 USA.
NR 55
TC 37
Z9 38
U1 0
U2 1
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0022-2623
EI 1520-4804
J9 J MED CHEM
JI J. Med. Chem.
PD MAR 17
PY 1995
VL 38
IS 6
BP 898
EP 905
DI 10.1021/jm00006a007
PG 8
WC Chemistry, Medicinal
SC Pharmacology & Pharmacy
GA QN521
UT WOS:A1995QN52100007
PM 7699705
ER
PT J
AU WANG, CG
LANGER, T
KAMATH, PG
GU, ZQ
SKOLNICK, P
FRYER, RI
AF WANG, CG
LANGER, T
KAMATH, PG
GU, ZQ
SKOLNICK, P
FRYER, RI
TI COMPUTER-AIDED MOLECULAR MODELING, SYNTHESIS, AND BIOLOGICAL EVALUATION
OF 8-(BENZYLOXY-2-PHENYLPYRAZOLO[4,3-C]QUINOLINE AS A NOVEL
BENZODIAZEPINE RECEPTOR AGONIST LIGAND
SO JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Article
ID BENZODIAZEPINE RECEPTOR; BINDING; ANALOGS
AB Using computer-aided conformational analysis, based on molecular dynamics simulation, cluster analysis, and Monte Carlo techniques, we have designed and synthesized compounds in which a benzyloxy substituent has been incorporated into a series of pyrazoloquinoline benzodiazepine receptor (BZR) ligands, Earlier studies had shown that the benzyloxy group could act as part of the agonist pharmacophoric determinant in the beta-carboline ring system. Furthermore, the agonist beta-carboline had been correlated with a binding site orientation and volume fit for an agonist 6-phenylimidazobenzodiazepine carboxylate. The present study was undertaken to determine whether the benzyloxy substituent could be used as an agonist pharmacophoric descriptor for the phenylpyrazolo[4,3-c]quinolin-3-one BZR ligands, The results of a determination of GABA shift ratios for the synthetic ligands indicate that 8-(benzyloxy)-2-phenylpyrazolo[4,3-c]quinolin-3-one can be predicted to be an agonist at the BZR.
C1 RUTGERS STATE UNIV, DEPT CHEM, NEWARK, NJ 07102 USA.
UNIV INNSBRUCK, INST PHARMAZEUT CHEM, A-6020 INNSBRUCK, AUSTRIA.
NIDDKD, NEUROSCI LAB, BETHESDA, MD 20892 USA.
NR 20
TC 18
Z9 18
U1 0
U2 3
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0022-2623
J9 J MED CHEM
JI J. Med. Chem.
PD MAR 17
PY 1995
VL 38
IS 6
BP 950
EP 957
DI 10.1021/jm00006a014
PG 8
WC Chemistry, Medicinal
SC Pharmacology & Pharmacy
GA QN521
UT WOS:A1995QN52100014
PM 7699711
ER
PT J
AU GORIN, AA
ZHURKIN, VB
OLSON, WK
AF GORIN, AA
ZHURKIN, VB
OLSON, WK
TI B-DNA TWISTING CORRELATES WITH BASE-PAIR MORPHOLOGY
SO JOURNAL OF MOLECULAR BIOLOGY
LA English
DT Article
DE DNA CONFORMATION; HETEROGENEITY; TWISTING; BASE SEQUENCE DEPENDENCE
ID T-G-G; CRYSTAL-STRUCTURE; MOLECULAR-STRUCTURE; C-G; CONFORMATIONAL
FLEXIBILITY; ANISOTROPIC FLEXIBILITY; POLYNUCLEOTIDE CHAINS; ATOMIC
RESOLUTION; HELIX STRUCTURE; ADENINE TRACT
AB The observed sequence dependence of the mean twist angles in 38 B-DNA crystal structures can be understood in terms of simple geometrical features of the constituent base-pairs. Structures with low twist appear to unwind in response to severe steric clashes of large exocyclic groups (such as NH2-NH2) in the major and minor grooves, while those with high twist are subjected to lesser contacts (H-O and H-H).
We offer a simple clash function that depends on base-pair morphology (i.e. the chemical constitution of base-pairs) and satisfactorily accounts for the twist angles of the ten common Watson-Crick dimer steps both in the solid state and in solution. The twist-clash correlation that we find here still holds when extended to modified bases. In addition to Calladine's purine-purine clashes, we add other close contacts between bases in the grooves, and consider the conformational restrictions on the geometry of the sugar-phosphate backbone (namely, we emphasize the tendency of DNA to conserve virtual backbone length).
The significance of this finding is threefold: (1) sequence-dependent DNA twisting is directly involved in protein-DNA interactions; (2) strong correlation between Twist and Roll helps to elucidate the bending of the double helix as a function of base sequence; (3) it is possible to anticipate the effects of chemical modifications on twisting and bending. The mutual correlations of other structural parameters with the twist make this angle a primary determinant of DNA conformational heterogeneity.
C1 RUTGERS STATE UNIV,DEPT CHEM,NEW BRUNSWICK,NJ 08903.
NCI,MATH BIOL LAB,BETHESDA,MD 20892.
RI Gorin, Andrey/B-1545-2014
FU NCI NIH HHS [N10-CO74102]; NIGMS NIH HHS [GM34809, GM20861]
NR 93
TC 327
Z9 336
U1 1
U2 8
PU ACADEMIC PRESS (LONDON) LTD
PI LONDON
PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX
SN 0022-2836
J9 J MOL BIOL
JI J. Mol. Biol.
PD MAR 17
PY 1995
VL 247
IS 1
BP 34
EP 48
DI 10.1006/jmbi.1994.0120
PG 15
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QM944
UT WOS:A1995QM94400006
PM 7897660
ER
PT J
AU FOLEY, TD
LINNOILA, M
AF FOLEY, TD
LINNOILA, M
TI NANOMOLAR CONCENTRATIONS OF OUABAIN BLOCK ETHANOL-INDUCIBLE NA+,
K+-ATPASE ACTIVITY IN BRAIN
SO EUROPEAN JOURNAL OF PHARMACOLOGY-ENVIRONMENTAL TOXICOLOGY AND
PHARMACOLOGY SECTION
LA English
DT Article
DE NA+,K+-ATPASE; ETHANOL; OUABAIN; K+ SYNAPTOSOME
ID CARDIAC-GLYCOSIDES; PURKINJE-FIBERS; SODIUM; NA,K-ATPASE; INHIBITION;
SENSITIVITY; STIMULATION; MEMBRANES; PUMP
AB The effect of low concentrations of ethanol on Na+,K+-ATPase activity, defined as ouabain-inhibitable Rb-86(+) (K+) uptake, was investigated in a crude synaptosome preparation which was subject to minimal subcellular fractionation procedures. Moderate (20-30%) but potent (EC(50) = 3.8 mM) stimulation of total ouabain (1 mM)-inhibitable K+ uptake by ethanol was observed following incubation periods of up to 20 min. The activity of the ethanol-induced component of K+ uptake was antagonized by nanomolar concentrations of ouabain. Thus, the moderate stimulation of total ouabain-inhibitable K+ uptake by ethanol was attributable to the activation of a component of K+ uptake which was very sensitive (VS; IC50 = 2.8 x 10(-10) M) to inhibition by ouabain. Slightly higher concentrations of ouabain (10(-9)-10(-6.6) M) stimulated K+ uptake above control (no ethanol or ouabain) in both the absence and presence of ethanol. The selectivity of the VS-ethanol interaction was demonstrated by the lack of any ethanol effect on two other components of ouabain-inhibitable K+ uptake which accounted for inhibition of K+ uptake by concentrations of ouabain above 10(-6.6) M and were defined as sensitive (S; IC50 = 10(-6) M) and insensitive (I; IC50 = 10(-4) M) to ouabain. These results define the ethanol-inducible component of ouabain-inhibitable Na+,K+-ATPase activity and promote the view that changes in Na+,K+-ATPase-dependent ion translocation may contribute to ethanol intoxication in vivo.
RP FOLEY, TD (reprint author), NIAAA,DIV INTRAMURAL CLIN & BIOL RES,LCS,12501 WASHINGTON AVE,ROCKVILLE,MD 20852, USA.
NR 37
TC 4
Z9 4
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0926-6917
J9 EUR J PHARM-ENVIRON
JI Eur. J. Pharmacol.-Environ. Toxicol. Pharmacol. Sect.
PD MAR 16
PY 1995
VL 292
IS 3-4
BP 287
EP 292
DI 10.1016/0926-6917(95)90034-9
PG 6
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA QP913
UT WOS:A1995QP91300011
PM 7796868
ER
PT J
AU LAVECCHIA, C
DAVANZO, B
NEGRI, E
DECARLI, A
BENICHOU, J
AF LAVECCHIA, C
DAVANZO, B
NEGRI, E
DECARLI, A
BENICHOU, J
TI ATTRIBUTABLE RISKS FOR STOMACH-CANCER IN NORTHERN ITALY
SO INTERNATIONAL JOURNAL OF CANCER
LA English
DT Article
ID GASTRIC-CANCER; DIET; EPIDEMIOLOGY
AB The proportions of gastric cancer cases attributable (or attributable risks, AR) to consumption of traditional foods (i.e., pasta, rice and maize), low intake of beta-carotene and vitamin C, short duration of use of an electric refrigerator, low educational level, and family history of gastric cancer were computed using data from a case-control study conducted in Northern Italy. Between 1985 and lune 1993 a total of 746 incident, histologically confirmed gastric cancer cases and 2,053 controls admitted to the same network of hospitals for acute, nonneoplastic, non-digestive-tract diseases, unrelated to long-term modifications of diet, were interviewed. The ARs were 48% for low intake of beta-carotene, 40% for high consumption of traditional foods, and 16% for low intake of vitamin C. Overall, these 3 dietary factors explained 73% of the gastric cancer cases in the population. Five percent of all cases were attributable to less than 30 years' use of an electric refrigerator, 15% to low educational level, and 5% to family history of gastric cancer. In individuals over age 60, a greater proportion of cases was attributable to traditional foods, low education and late adoption of electric refrigeration (58% vs. 32% aged under 60), suggesting that correlates of lower social class, influenced lifestyle and dietary habits more markedly in earlier than in more recent generations. According to our estimates, over 3 quarters of the gastric cancer cases in this area are explainable in terms of the risk factors considered. Increased consumption of vitamin C and beta-carotene, and reduced consumption of traditional foods, would help to avoid over 10,000 out of 14,000 stomach-cancer deaths in Italy every year. Consequently, stomach cancer, which is still the third leading cause of cancer death in Italy, would represent only about 2% of all cancer deaths. (C) 1995 Wiley-Liss, Inc.
C1 UNIV MILAN,IST NAZL TUMORI,IST STAT MED & BIOMETRIA,I-20133 MILAN,ITALY.
NCI,EPIDEMIOL METHODS SECT,ROCKVILLE,MD 20892.
RP LAVECCHIA, C (reprint author), IST RIC FARMACOL MARIO NEGRI,VIA ERITREA 62,I-20157 MILAN,ITALY.
RI Negri, Eva/B-7244-2013; Decarli, Adriano/C-3129-2017;
OI Negri, Eva/0000-0001-9712-8526; Decarli, Adriano/0000-0003-1451-8292; La
Vecchia, Carlo/0000-0003-1441-897X
NR 22
TC 26
Z9 26
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0020-7136
J9 INT J CANCER
JI Int. J. Cancer
PD MAR 16
PY 1995
VL 60
IS 6
BP 748
EP 752
PG 5
WC Oncology
SC Oncology
GA QN875
UT WOS:A1995QN87500002
PM 7896439
ER
PT J
AU CRAVEN, RJ
XU, LH
WEINER, TM
FRIDELL, YW
DENT, GA
SRIVASTAVA, S
VARNUM, B
LIU, ET
CANCE, WG
AF CRAVEN, RJ
XU, LH
WEINER, TM
FRIDELL, YW
DENT, GA
SRIVASTAVA, S
VARNUM, B
LIU, ET
CANCE, WG
TI RECEPTOR TYROSINE KINASES EXPRESSED IN METASTATIC COLON-CANCER
SO INTERNATIONAL JOURNAL OF CANCER
LA English
DT Article
ID GROWTH-FACTOR RECEPTOR; PP60C-SRC PROTEIN-KINASE; HUMAN-BREAST-CANCER;
NIH 3T3 CELLS; CARCINOMA CELLS; OVEREXPRESSION; TRANSFORMATION;
TUMORIGENESIS; AMPLIFICATION; ACTIVATION
AB Using a PCR-based cloning technique, we have isolated a series of DNA fragments coding for tyrosine kinases that are expressed in a metastatic human colon tumor, and have subsequently analyzed their expression pattern at the protein level in human tumors. We identified both the alpha and the beta forms of the platelet-derived growth factor receptor (PDGFR), axl and 8 other genes, including 3 cytoplasmic tyrosine kinases. To study their expression in human colon cancer, we performed Western blots of matched sets of normal tissues and of carcinomas from the same patient. These revealed that the alpha-PDGFR migrates predominantly as a 200-kDa band in 8/8 normal tissues, and as a 170-kDa band in 17/17 malignant tissues, as well as in colonic polyps, suggesting that expression of an isoform of this receptor may be a marker for the progression of colon cancer. Additional studies showed that the Axl receptor tyrosine kinase was expressed at 10-fold higher levels in a peritoneal metastatic nodule than in other normal and malignant tissues. Immunohistochemistry revealed Axl over-expression specifically in the malignant cells of the tumor. This indicates that over-expression and possibly a differential processing event of tyrosine kinase receptors may be involved in colon cancer, and that they are potential markers for the progression of this disease. (C) 1995 Wiley-Liss, Inc.
C1 UNIV N CAROLINA,SCH MED,LINEBERGER COMPREHENS CANC CTR,CHAPEL HILL,NC 27599.
UNIV N CAROLINA,SCH MED,CURRICULUM GENET & MOLEC BIOL,CHAPEL HILL,NC 27599.
UNIV N CAROLINA,SCH MED,DEPT SURG,CHAPEL HILL,NC 27599.
UNIV N CAROLINA,SCH MED,DEPT PATHOL,CHAPEL HILL,NC 27599.
UNIV N CAROLINA,SCH MED,DEPT MED,CHAPEL HILL,NC 27599.
NCI,BETHESDA,MD 20892.
AMGEN CORP,THOUSAND OAKS,CA 91320.
RI Liu, Edison/C-4141-2008
FU NCI NIH HHS [K08-CA01625, N-01-CN-25421-02, T32-CA09688]
NR 29
TC 106
Z9 114
U1 0
U2 1
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0020-7136
J9 INT J CANCER
JI Int. J. Cancer
PD MAR 16
PY 1995
VL 60
IS 6
BP 791
EP 797
DI 10.1002/ijc.2910600611
PG 7
WC Oncology
SC Oncology
GA QN875
UT WOS:A1995QN87500010
PM 7896447
ER
PT J
AU MISIK, V
MIYOSHI, N
RIESZ, P
AF MISIK, V
MIYOSHI, N
RIESZ, P
TI EPR SPIN-TRAPPING STUDY OF THE SONOLYSIS OF H2O/D2O MIXTURES - PROBING
THE TEMPERATURES OF CAVITATION REGIONS
SO JOURNAL OF PHYSICAL CHEMISTRY
LA English
DT Article
ID SONOCHEMISTRY; RADICALS; TRAPS; ULTRASOUND; MOLECULES
AB High temperatures and pressures are generated during the violent collapse of acoustic cavitation bubbles produced by ultrasound in liquids. The semiclassical model of the temperature dependence of the kinetic isotope effect for H-. and D-. atom formation was used to estimate the effective temperature of the hot cavitation regions in which H-. and D-. atoms are formed by ultrasound-induced pyrolysis of water molecules. The H-. and D-. atoms were formed in argon-saturated H2O and D2O mixtures (1:1) exposed to 50 kHz ultrasound and were detected by spin trapping with the nitrone spin traps N-tert-butyl-alpha-phenylnitrone (PEN), alpha-(4-pyridyl-1 -oxy)-N-tert-butylnitrone (POBN), alpha-(4-pyridyl-1-methyl)-N-tert-butylnitrone (PYBN), and 5,5-dimethyl-1-pyrroline N-oxide (DMPO). The resulting spin adducts were identified and quantified by EPR spectroscopy. Because of the higher stability of H- and D-adducts, the PEN-type spin traps were found to be more suitable than DMPO for the measurement of H-. and D-. atoms (in our experimental system the half-lifes of PBN/H-. and DMPO/H-. were similar to 600 and similar to 40 s, respectively). An isotope effect on spin adduct stability was also observed: the decay rates of PEN-type H-adducts were similar to 1.2 times higher than those of the corresponding D-adducts, and the decay rate of DMPO/H-. was 2.4 times higher than that of DMPO/D-.. The effective temperatures of O-H bond pyrolysis determined from the semiclassical treatment are in the region of similar to 2000-4000 K using the PEN-type spin traps. This estimate may be compared to the temperatures (similar to 5000 K) determined by Suslick ct al. for the gas phase of the cavitation bubbles in alkanes and (approximate to 1900 K) for the interfacial region of the cavitation bubbles [Suslick, K. S., ct al. J. Am. Chem. Sec. 1986, 108, 5641].
C1 NCI,RADIAT BIOL BRANCH,BETHESDA,MD 20892.
NR 33
TC 114
Z9 115
U1 3
U2 10
PU AMER CHEMICAL SOC
PI WASHINGTON
PA PO BOX 57136, WASHINGTON, DC 20037-0136
SN 0022-3654
J9 J PHYS CHEM-US
JI J. Phys. Chem.
PD MAR 16
PY 1995
VL 99
IS 11
BP 3605
EP 3611
DI 10.1021/j100011a030
PG 7
WC Chemistry, Physical
SC Chemistry
GA QN284
UT WOS:A1995QN28400030
ER
PT J
AU BORICK, SS
DEBENEDETTI, PG
SASTRY, S
AF BORICK, SS
DEBENEDETTI, PG
SASTRY, S
TI A LATTICE MODEL OF NETWORK-FORMING FLUIDS WITH ORIENTATION-DEPENDENT
BONDING - EQUILIBRIUM, STABILITY, AND IMPLICATIONS FOR THE
PHASE-BEHAVIOR OF SUPERCOOLED WATER
SO JOURNAL OF PHYSICAL CHEMISTRY
LA English
DT Article
ID LONG-TIME REGIME; LIQUID WATER; MOLECULAR-DYNAMICS; HEAVY-WATER;
ISOTHERMAL COMPRESSIBILITY; AQUEOUS-SOLUTIONS; LOW-TEMPERATURES; ICE-I;
TRANSITIONS; DENSITY
AB We use a lattice model with orientation-dependent interactions to study network-forming fluids, such as water and silica. Bonds can form between pairs of molecules that have correct mutual orientation and correct separation; they can be weakened by the presence of other molecules sufficiently close to a bonded pair. These interactions give rise to competition between bonded states of low energy, density, and entropy and nonbonded states of high energy, density, and entropy. By suitable choice of parameters, the mean-field solution of the model yields the two different scenarios (stability limit conjecture and second critical point) that have been proposed to explain the anomalous behavior of supercooled water. The model's generality suggests that similar behavior can occur in other network-forming fluids.
C1 PRINCETON UNIV,DEPT CHEM ENGN,PRINCETON,NJ 08544.
NIH,DIV COMP RES & TECHNOL,PHYS SCI LAB,BETHESDA,MD 20892.
NR 85
TC 95
Z9 95
U1 2
U2 11
PU AMER CHEMICAL SOC
PI WASHINGTON
PA PO BOX 57136, WASHINGTON, DC 20037-0136
SN 0022-3654
J9 J PHYS CHEM-US
JI J. Phys. Chem.
PD MAR 16
PY 1995
VL 99
IS 11
BP 3781
EP 3792
DI 10.1021/j100011a054
PG 12
WC Chemistry, Physical
SC Chemistry
GA QN284
UT WOS:A1995QN28400054
ER
PT J
AU BOZZETTE, SA
FINKELSTEIN, DM
SPECTOR, SA
FRAME, P
POWDERLY, WG
HE, WL
PHILLIPS, L
CRAVEN, D
VANDERHORST, C
FEINBERG, J
AF BOZZETTE, SA
FINKELSTEIN, DM
SPECTOR, SA
FRAME, P
POWDERLY, WG
HE, WL
PHILLIPS, L
CRAVEN, D
VANDERHORST, C
FEINBERG, J
TI A RANDOMIZED TRIAL OF 3 ANTIPNEUMOCYSTIS AGENTS IN PATIENTS WITH
ADVANCED HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Article
ID PNEUMOCYSTIS-CARINII PNEUMONIA; AEROSOLIZED PENTAMIDINE;
TRIMETHOPRIM-SULFAMETHOXAZOLE; PRIMARY PROPHYLAXIS; SECONDARY
PROPHYLAXIS; DAPSONE-PYRIMETHAMINE; PRIMARY PREVENTION; AIDS;
COTRIMOXAZOLE; ZIDOVUDINE
AB Background. We evaluated the effectiveness of three treatment strategies for the prevention of a first episode of Pneumocystis carinii pneumonia in patients infected with the human immunodeficiency virus (HIV).
Methods. In an open-label trial, 843 patients with HIV infection and fewer than 200 CD4+ cells per cubic millimeter received zidovudine plus one of three randomly assigned prophylactic agents, beginning with trimethoprim-sulfamethoxazole, dapsone, or aerosolized pentamidine and followed by a defined sequence of other drugs to be used in cases of intolerance.
Results. The estimated 36-month cumulative risks of P. carinii pneumonia were 18 percent, 17 percent, and 21 percent in the trimethoprim-sulfamethoxazole, dapsone, and aerosolized-pentamidine groups, respectively (P = 0.22). The difference in risk among treatment strategies was negligible in patients entering the study with 100 or more CD4+ lymphocytes per cubic millimeter. In those entering with fewer than 100 CD4+ cells per cubic millimeter, the risk was 33 percent with aerosolized pentamidine, as compared with 19 percent with trimethoprim-sulfamethoxazole and 22 percent with dapsone (P=0.04). The lowest failure rates occurred in patients receiving trimethoprim-sulfamethoxazole, acid failures were more common with 50 mg of dapsone than with 100 mg. Toxoplasmosis developed in less than 3 percent of patients. Of the patients assigned to the two systemic therapies, only 23 percent were receiving their assigned drug and dose when they completed the study. The median survival was approximately 39 months in all three groups, and the mortality attributable to P. carinii pneumonia was only 1 percent.
Conclusions. In patients with advanced HIV infection, the three treatment strategies we examined have similar effectiveness in preventing P. carinii pneumonia. Strategies that start with trimethoprim-sulfamethoxazole or with high-dose dapsone, rather than aerosolized pentamidine, are superior in patients with fewer than 100 CD4+ lymphocytes per cubic millimeter.
C1 UNIV CALIF SAN DIEGO,LA JOLLA,CA 92093.
RAND CORP,SANTA MONICA,CA.
HARVARD UNIV,SCH PUBL HLTH,BOSTON,MA 02115.
UNIV CINCINNATI,CINCINNATI,OH.
WASHINGTON UNIV,SCH MED,ST LOUIS,MO.
FRONTIER SCI TECHNOL & RES FDN,BUFFALO,NY.
BOSTON UNIV,BOSTON,MA 02215.
UNIV N CAROLINA,CHAPEL HILL,NC.
NIAID,BETHESDA,MD 20892.
JOHNS HOPKINS UNIV,BALTIMORE,MD.
RP BOZZETTE, SA (reprint author), VET AFFAIRS MED CTR,MAIL CODE 111N-1,3350 LA JOLLA VILLAGE DR,SAN DIEGO,CA 92161, USA.
NR 24
TC 226
Z9 230
U1 0
U2 0
PU MASS MEDICAL SOC
PI BOSTON
PA 10 SHATTUCK, BOSTON, MA 02115
SN 0028-4793
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD MAR 16
PY 1995
VL 332
IS 11
BP 693
EP 699
DI 10.1056/NEJM199503163321101
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA QL788
UT WOS:A1995QL78800001
PM 7854375
ER
PT J
AU POWDERLY, WG
FINKELSTEIN, DM
FEINBERG, J
FRAME, P
HE, WL
VANDERHORST, C
KOLETAR, SL
EYSTER, ME
CAREY, J
WASKIN, H
HOOTON, TM
HYSLOP, N
SPECTOR, SA
BOZZETTE, SA
AF POWDERLY, WG
FINKELSTEIN, DM
FEINBERG, J
FRAME, P
HE, WL
VANDERHORST, C
KOLETAR, SL
EYSTER, ME
CAREY, J
WASKIN, H
HOOTON, TM
HYSLOP, N
SPECTOR, SA
BOZZETTE, SA
TI A RANDOMIZED TRIAL COMPARING FLUCONAZOLE WITH CLOTRIMAZOLE TROCHES FOR
THE PREVENTION OF FUNGAL-INFECTIONS IN PATIENTS WITH ADVANCED
HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Article
ID PNEUMOCYSTIS-CARINII PNEUMONIA; AEROSOLIZED PENTAMIDINE; CRYPTOCOCCAL
MENINGITIS; TRIMETHOPRIM SULFAMETHOXAZOLE; AMPHOTERICIN-B; PROPHYLAXIS;
AIDS; COMPLEX; THERAPY; RELAPSE
AB Background. Cryptococcal meningitis and other serious fungal infections are common complications in patients infected with the human immunodeficiency virus (HIV). Fluconazole is effective for long-term suppression of many fungal infections, but its effectiveness as primary prophylaxis had not been adequately evaluated.
Methods. We conducted a prospective, randomized trial that compared fluconazole (200 mg per day) with clotrimazole troches (10 mg taken five times daily) in patients who were also participating in a randomized trial of primary prophylaxis for Pneumocystis carinii pneumonia.
Results. After a median follow-up of 35 months, invasive fungal infections had developed in 4.1 percent of the patients in the fluconazole group (9 of 217) and in 10.9 percent of those in the clotrimazole group (23 of 211, relative hazard, as adjusted for the CD4+ count, 3.3; 95 percent confidence interval, 1.5 to 7.6). Of the 32 invasive fungal infections, 17 were cryptococcosis (2 in the fluconatole group and 15 in the clotrimazole group; adjusted relative hazard, 8.5; 95 percent confidence interval, 1.9 to 37.6). The benefit of fluconazole was greater for the patients with 50 or fewer CD4+ cells per cubic millimeter than for the patients with higher counts. Fluconazole was also effective in preventing esophageal candidiasis (adjusted relative hazard, 5.8; 95 percent confidence interval, 1.7 to 20.0; P=0.004) and confirmed and presumed oropharyngeal candidiasis (5.7 and 38.1 cases per 100 person-years of follow-up in the fluconazole and clotrimazole groups, respectively; P < 0.001). Survival was similar in the two groups.
Conclusions. Fluconazole taken prophylactically reduces the frequency of cryptococcosis, esophageal candidiasis, and superficial fungal infections in HIV-infected patients, especially those with 50 or fewer CD4+ lymphocytes per cubic millimeter, but the drug does not reduce overall mortality.
C1 VET AFFAIRS MED CTR,SAN DIEGO,CA 92161.
WASHINGTON UNIV,SCH MED,ST LOUIS,MO.
HARVARD UNIV,SCH PUBL HLTH,CTR STAT & DATA ANAL,BOSTON,MA 02115.
NIAID,BETHESDA,MD 20892.
JOHNS HOPKINS UNIV,BALTIMORE,MD.
UNIV CINCINNATI,CINCINNATI,OH.
UNIV N CAROLINA,CHAPEL HILL,NC.
OHIO STATE UNIV,COLUMBUS,OH 43210.
PENN STATE UNIV,COLL MED,HERSHEY,PA.
CASE WESTERN RESERVE UNIV,SCH MED,CLEVELAND,OH.
DUKE UNIV,DURHAM,NC.
UNIV WASHINGTON,SEATTLE,WA 98195.
TULANE UNIV,NEW ORLEANS,LA 70118.
UNIV CALIF SAN DIEGO,LA JOLLA,CA 92093.
RAND CORP,SANTA MONICA,CA.
NR 18
TC 241
Z9 247
U1 0
U2 0
PU MASS MEDICAL SOC
PI BOSTON
PA 10 SHATTUCK, BOSTON, MA 02115
SN 0028-4793
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD MAR 16
PY 1995
VL 332
IS 11
BP 700
EP 705
DI 10.1056/NEJM199503163321102
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA QL788
UT WOS:A1995QL78800002
PM 7854376
ER
PT J
AU MOFENSON, LM
NUGENT, R
AF MOFENSON, LM
NUGENT, R
TI PROPHYLACTIC IMMUNE GLOBULIN IN CHILDREN WITH HIV DISEASE
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Letter
RP MOFENSON, LM (reprint author), NIH,BETHESDA,MD 20892, USA.
NR 8
TC 1
Z9 1
U1 0
U2 0
PU MASS MEDICAL SOC
PI BOSTON
PA 10 SHATTUCK, BOSTON, MA 02115
SN 0028-4793
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD MAR 16
PY 1995
VL 332
IS 11
BP 750
EP 751
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA QL788
UT WOS:A1995QL78800020
PM 7854391
ER
PT J
AU PEEBLES, RS
MALISZEWSKI, CR
SATO, TA
HANLEYHYDE, J
MAROULAKOU, IG
HUNZIKER, R
SCHNECK, JP
GREEN, JE
AF PEEBLES, RS
MALISZEWSKI, CR
SATO, TA
HANLEYHYDE, J
MAROULAKOU, IG
HUNZIKER, R
SCHNECK, JP
GREEN, JE
TI ABNORMAL B-CELL FUNCTION IN HTLV-I-TAX TRANSGENIC MICE
SO ONCOGENE
LA English
DT Article
DE HTLV-I; GROWTH FACTORS; B-CELLS; TRANSGENIC MICE; LYMPHOPROLIFERATION;
AUTOIMMUNE DISEASE
ID VIRUS TYPE-I; TROPICAL SPASTIC PARAPARESIS; COLONY-STIMULATING FACTOR;
PRIMARY SJOGRENS-SYNDROME; EPSTEIN-BARR-VIRUS; HEPATITIS-C VIRUS;
INTERLEUKIN-2 RECEPTOR; MOUSE MODEL; ACTIVATION; GENE
AB Transgenic mice that carry the HTLV-I Tax gene develop an exocrinopathy with some similarities to Sjoegren's syndrome. Our experiments reveal that these mice have lymphadenopathy and splenomegaly composed primarily of B lymphocytes, as well as abnormal levels of secreted immunoglobulins. To gain insight into whether the lymphadenopathy manifested by these transgenic mice was the result of induction of cytokines by Tax, we utilized cell lines from these mice to study in vitro B-cell responses. Conditioned media (CM) derived from the cell lines caused B-cells to proliferate when a second signal, surface Ig cross-linking, was provided. The CM also caused a marked enhancement of IgM secretion by spleen cells or by purified B-cells treated with supplemental cytokines. The B-cell proliferative response and enhanced IgM secretion have not been attributed to a known cytokine. These results suggest that the CM from the cell lines contain a factor(s) involved in novel pathways of B-cell growth and differentiation that may participate in the pathologic development of autoimmune disease.
C1 NCI,MOLEC ONCOL LAB,FREDERICK,MD 21702.
JOHNS HOPKINS UNIV,SCH MED,DEPT MED,DIV CLIN IMMUNOL,BALTIMORE,MD 21224.
NCI,GENET LAB,BETHESDA,MD 20892.
IMMUNEX CORP,DEPT CELLULAR IMMUNOL,BETHESDA,MD 20892.
NR 40
TC 17
Z9 17
U1 1
U2 1
PU STOCKTON PRESS
PI BASINGSTOKE
PA HOUNDMILLS, BASINGSTOKE, HANTS, ENGLAND RG21 2XS
SN 0950-9232
J9 ONCOGENE
JI Oncogene
PD MAR 16
PY 1995
VL 10
IS 6
BP 1045
EP 1051
PG 7
WC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics &
Heredity
SC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics &
Heredity
GA QN353
UT WOS:A1995QN35300003
PM 7700628
ER
PT J
AU SMITH, ML
CHEN, IT
ZHAN, QM
OCONNOR, PM
FORNACE, AJ
AF SMITH, ML
CHEN, IT
ZHAN, QM
OCONNOR, PM
FORNACE, AJ
TI INVOLVEMENT OF THE P53 TUMOR-SUPPRESSOR IN REPAIR OF UV-TYPE DNA-DAMAGE
SO ONCOGENE
LA English
DT Article
DE P53; UV; DNA REPAIR; GADD45; HPV E6; CHECKPOINTS
ID EXCISION REPAIR; IONIZING-RADIATION; CELLULAR-RESPONSE;
ESCHERICHIA-COLI; PROTEIN; GENE; ACTIVATION; CHECKPOINT; APOPTOSIS;
AGENTS
AB The tumor suppressor p53 plays a central role in the cellular responses to genotoxic stress. Besides its well known role in activation of the G(1) checkpoint after exposure to agents like ionizing radiation and its role in apoptosis, the possibility exists that p53 may have additional roles, such as in DNA repair. For example, p53, is known to bind to single strand DNA such as would occur during repair events, and the proteins encoded by two p53-regulated genes have previously been found to bind to at least one protein involved in DNA damage processing including nucleotide excision repair (NER). NER is an important and versatile DNA repair mechanism, which is the major pathway for repair of u.v.-type lesions and damage by a variety of important carcinogens and mutagens. If components of the p53 pathway are involved in NER, then disruption of p53 function by mutations or expression of certain viral proteins could have important implications in carcinogenesis and cancer treatment. In the present study we show that disruption of normal p53 function in human colon carcinoma RKO cells with either the human papillomavirus E6 oncoprotein or a dominant-negative mutant p53 transgene results in reduced repair of u.v.-induced DNA damage. The E6 and mutant p53-containing cell lines demonstrated reduced repair of u.v.-induced DNA lesions in host cell reactivation experiments with reporter plasmids, and reduced repair in in vitro DNA repair assays. With this in vitro assay, extracts from the E6- and mutant p53-containing lines also showed loss of induced repair following cellular u.v.-irradiation. The reduced DNA repair activity of the transfected cell lines also correlated with reduced clonogenic survival following u.v.-irradiation. These results indicate that p53 and/or p53-regulated gene products function in the NER pathway and that this process is inducible by DNA damage.
RP SMITH, ML (reprint author), NCI,DIV CANC TREATMENT,MOLEC PHARMACOL LAB,DEV THERAPEUT PROGRAM,BLDG 37,ROOM 5C09,BETHESDA,MD 20892, USA.
RI Fornace, Albert/A-7407-2008
OI Fornace, Albert/0000-0001-9695-085X
NR 64
TC 355
Z9 357
U1 2
U2 11
PU STOCKTON PRESS
PI BASINGSTOKE
PA HOUNDMILLS, BASINGSTOKE, HANTS, ENGLAND RG21 2XS
SN 0950-9232
J9 ONCOGENE
JI Oncogene
PD MAR 16
PY 1995
VL 10
IS 6
BP 1053
EP 1059
PG 7
WC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics &
Heredity
SC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics &
Heredity
GA QN353
UT WOS:A1995QN35300004
PM 7700629
ER
PT J
AU JONES, TL
KARAVANOVA, I
MAENO, M
ONG, RC
KUNG, HF
DAAR, IO
AF JONES, TL
KARAVANOVA, I
MAENO, M
ONG, RC
KUNG, HF
DAAR, IO
TI EXPRESSION OF AN AMPHIBIAN HOMOLOG OF THE EPH FAMILY OF RECEPTOR
TYROSINE KINASES IS DEVELOPMENTALLY-REGULATED
SO ONCOGENE
LA English
DT Article
DE EPH; TYROSINE KINASE; XENOPUS LAEVIS
ID XENOPUS-EMBRYOS; PROTEIN-KINASES; CDNA CLONING; W-LOCUS; GENE; MOUSE;
DROSOPHILA; IDENTIFICATION; ENCODES; CHICKEN
AB In order to study the function of tyrosine kinase receptors during Xenopus development, we have isolated Xek (Xenopus Elk-like kinase), a tyrosine kinase receptor, which shows significant homology to rat Elk and chicken cek5, members of the Eph family. Xek exists as a maternally expressed mRNA which decreases in expression at the mid blastula transition and reappears at late neurulation in Xenopus, Xek mRNA is expressed at higher levels in the anterior and dorsal regions of embryonic stages 16, 24 and 37. In adult Xenopus tissues, Xek appears to be ubiquitously expressed with higher expression observed in brain and ovary, In situ hybridization analysis demonstrates localized mRNA expression in the brain, brachial arches, trigeminal facial ganglion, and the retina of the swimming tadpole stage of development. The similarities in sequence and expression pattern suggest that Xek is an amphibian member of the Eph family and may play a role in the development or function of the central nervous system.
C1 NCI,FREDERICK CANC RES & DEV CTR,LEUKOCYTE BIOL LAB,BIOL RESPONSE MODIFIERS PROGRAM,FREDERICK,MD 21702.
NCI,FREDERICK CANC RES & DEV CTR,COMPARAT CARCINOGENESIS LAB,FREDERICK,MD 21702.
NCI,FREDERICK CANC RES & DEV CTR,BIOCHEM PHYSIOL LAB,FREDERICK,MD 21702.
OI Daar, Ira/0000-0003-2657-526X
NR 48
TC 28
Z9 31
U1 0
U2 0
PU STOCKTON PRESS
PI BASINGSTOKE
PA HOUNDMILLS, BASINGSTOKE, HANTS, ENGLAND RG21 2XS
SN 0950-9232
J9 ONCOGENE
JI Oncogene
PD MAR 16
PY 1995
VL 10
IS 6
BP 1111
EP 1117
PG 7
WC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics &
Heredity
SC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics &
Heredity
GA QN353
UT WOS:A1995QN35300011
PM 7700636
ER
PT J
AU ZIMONJIC, DB
ALIMANDI, M
MIKI, T
POPESCU, NC
KRAUS, MH
AF ZIMONJIC, DB
ALIMANDI, M
MIKI, T
POPESCU, NC
KRAUS, MH
TI LOCALIZATION OF THE HUMAN HER4/ERBB-4 GENE TO CHROMOSOME-2
SO ONCOGENE
LA English
DT Note
DE RECEPTOR TYROSINE KINASE; ERBB FAMILY; GENE MAPPING; FISH
ID FACTOR RECEPTOR FAMILY; FRAGILE SITES; TRANSLOCATION (2-13)(Q37-Q14);
ALVEOLAR RHABDOMYOSARCOMA; NERVOUS-SYSTEM; ONCOGENE; MEMBER;
HER4/P180(ERBB4); EXPRESSION; HEREGULIN
AB The HER4/erbB-4 gene has been isolated as the fourth member of the human EGFR subfamily of tyrosine kinases and has been reported to encode a receptor for NDF/heregulin. In the present study we determined the chromosomal location of the HER4/erbB-4 gene within the human genome. Using human cDNA probes in fluorescence in situ hybridization (FISH), we mapped the HER4/erbB-4 gene to human chromosome 2q33.3-34. This finding established that also the HER4/erbB-4 gene is located in close vicinity of homeobox and collagen gene loci, as is the case for the related EGFR, erbB-2/neu and erbB-3. Aberrations of this chromosomal region associated with T cell leukemias and lymphomas as well as alveolar rhabdomyosarcomas raise the possibility that HER4/erbB-4 might be activated in these tumour types.
C1 NCI,CELLULAR & MOLEC BIOL LAB,BETHESDA,MD 20892.
NCI,BIOL LAB,BETHESDA,MD 20892.
NR 31
TC 26
Z9 30
U1 1
U2 3
PU STOCKTON PRESS
PI BASINGSTOKE
PA HOUNDMILLS, BASINGSTOKE, HANTS, ENGLAND RG21 2XS
SN 0950-9232
J9 ONCOGENE
JI Oncogene
PD MAR 16
PY 1995
VL 10
IS 6
BP 1235
EP 1237
PG 3
WC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics &
Heredity
SC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics &
Heredity
GA QN353
UT WOS:A1995QN35300026
PM 7700649
ER
PT J
AU BATES, MN
SMITH, AH
CANTOR, KP
AF BATES, MN
SMITH, AH
CANTOR, KP
TI CASE-CONTROL STUDY OF BLADDER-CANCER AND ARSENIC IN DRINKING-WATER
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE ARSENIC; BLADDER NEOPLASMS; SMOKING; WATER POLLUTANTS; WATER SUPPLY
ID DISEASE ENDEMIC AREA; MALIGNANT NEOPLASMS; RESPIRATORY CANCER; SODIUM
ARSENITE; COPPER SMELTER; LUNG-CANCER; WELL WATER; MORTALITY; EXPOSURE;
CARCINOGENESIS
AB Mortality from several cancers, including bladder cancer, is elevated in a Taiwanese population exposed to high levels of arsenic in drinking water. Data from the Utah respondents to the National Bladder Cancer Study conducted in 1978 were used to evaluate these associations in a US population exposed to measurable, but much lower, levels of drinking water arsenic. Two indices of cumulative arsenic exposure were used, one representing total cumulative exposure (index 1) and the other, intake concentration (index 2). Overall, there was no association of bladder cancer with either measure; however, among smokers, but not among nonsmokers, positive trends in risk were found for exposures estimated for decade-long time periods, especially in the 30- to 39-year period prior to diagnosis. Exposures were in the range 0.5-160 mu g/liter (mean, 5.0 mu g/liter). The data raise the possibility that smoking potentiates the effect of arsenic on risk of bladder cancer. However, the risk estimates obtained are much higher than predicted on the basis of the results of the Taiwanese studies, raising concerns about bias or the role of chance. Confirmatory studies are needed.
C1 UNIV CALIF BERKELEY,SCH PUBL HLTH,DEPT BIOMED & ENVIRONM HLTH SCI,BERKELEY,CA 94720.
NCI,ENVIRONM EPIDEMIOL BRANCH,BETHESDA,MD 20892.
RI Smith, Allan/F-9249-2011
FU NIEHS NIH HHS [ES-01896, P42 ES-04705]
NR 36
TC 168
Z9 169
U1 0
U2 2
PU AMER J EPIDEMIOLOGY
PI BALTIMORE
PA 624 N BROADWAY RM 225, BALTIMORE, MD 21205
SN 0002-9262
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD MAR 15
PY 1995
VL 141
IS 6
BP 523
EP 530
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA QN480
UT WOS:A1995QN48000006
PM 7900719
ER
PT J
AU ROWLAND, AS
BAIRD, DD
SHORE, DL
WEINBERG, CR
SAVITZ, DA
WILCOX, AJ
AF ROWLAND, AS
BAIRD, DD
SHORE, DL
WEINBERG, CR
SAVITZ, DA
WILCOX, AJ
TI NITROUS-OXIDE AND SPONTANEOUS-ABORTION IN FEMALE DENTAL ASSISTANTS
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE ABORTION, SPONTANEOUS; AIR POLLUTANTS, OCCUPATIONAL; COHORT STUDIES;
DENTAL STAFF; NITROUS OXIDE; OCCUPATIONAL DISEASES
ID SPRAGUE-DAWLEY RATS; ANESTHETIC-GASES; OCCUPATIONAL EXPOSURE; FOLINIC
ACID; NITRIC-OXIDE; WOMEN; MALFORMATIONS; HOMOCYSTEINE; EMPLOYMENT;
PREGNANCY
AB The relation between anesthetic gas exposure and spontaneous abortion remains unresolved. We examined the effect of nitrous oxide on spontaneous abortion among female dental assistants. Questionnaires were sent to 7,000 dental assistants aged 18-39 years who were registered in California in 1987; 4,856 (69%) responded. Analysis was based on 1,465 respondents whose most recent pregnancy was conceived while working full time. Women were asked how many times a week they worked with nitrous oxide during this pregnancy and whether the excess gas was scavenged (vented). Relative risk of spontaneous abortion (through week 20) was calculated using a person-week model. This allowed women with current pregnancies (13%) or induced abortions (10%) to be included for appropriate time periods of risk. A total of of 101 pregnancies (7%) ended as spontaneous abortions. An elevation of risk of spontaneous abortions was seen among women who worked with nitrous oxide for 3 or more per week in offices not using scavenging equipment (relative risk = 2.6, 95% confidence interval 1.3-5.0, adjusted for age, smoking and number of amalgams prepared per week), but not among those using nitrous oxide in offices with scavenging equipment. This relation changed little when analyses were restricted to confirmed pregnancies or examined for several types of potential bias. Scavenging equipment appears to be important in protecting the reproductive health of women working with nitrous oxide.
C1 WESTAT CORP,DURHAM,NC.
NIEHS,STAT & BIOMATH BRANCH,RES TRIANGLE PK,NC 27709.
UNIV N CAROLINA,SCH PUBL HLTH,DEPT EPIDEMIOL,CHAPEL HILL,NC.
RP ROWLAND, AS (reprint author), NIEHS,EPIDEMIOL BRANCH A3 05,POB 12233,RES TRIANGLE PK,NC 27709, USA.
OI Wilcox, Allen/0000-0002-3376-1311; Baird, Donna/0000-0002-5544-2653
NR 53
TC 115
Z9 116
U1 0
U2 5
PU AMER J EPIDEMIOLOGY
PI BALTIMORE
PA 624 N BROADWAY RM 225, BALTIMORE, MD 21205
SN 0002-9262
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD MAR 15
PY 1995
VL 141
IS 6
BP 531
EP 538
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA QN480
UT WOS:A1995QN48000007
PM 7900720
ER
PT J
AU DAQUILA, RT
JOHNSON, VA
WELLES, SL
JAPOUR, AJ
KURITZKES, DR
DEGRUTTOLA, V
REICHELDERFER, PS
COOMBS, RW
CRUMPACKER, CS
KAHN, JO
RICHMAN, DD
AF DAQUILA, RT
JOHNSON, VA
WELLES, SL
JAPOUR, AJ
KURITZKES, DR
DEGRUTTOLA, V
REICHELDERFER, PS
COOMBS, RW
CRUMPACKER, CS
KAHN, JO
RICHMAN, DD
TI ZIDOVUDINE RESISTANCE AND HIV-1 DISEASE PROGRESSION DURING
ANTIRETROVIRAL THERAPY
SO ANNALS OF INTERNAL MEDICINE
LA English
DT Article
DE ZIDOVUDINE; DRUG RESISTANCE; HUMAN IMMUNODEFICIENCY VIRUS-1; ANTIVIRAL
AGENTS; DIDANOSINE
ID HUMAN-IMMUNODEFICIENCY-VIRUS; SYNCYTIUM-INDUCING PHENOTYPE;
REVERSE-TRANSCRIPTASE; SENSITIVITY; CAPACITY; CHILDREN; MUTATION;
INVITRO; AIDS
AB Objective: To evaluate the association between resistance of human immunodeficiency virus type 1 (HIV-1) to zidovudine and clinical progression.
Design: Retrospective analysis of specimens from patients in the AIDS Clinical Trials Group (ACTG) protocol 116B/117, a randomized comparison of didanosine with continued zidovudine therapy in patients with advanced HIV-1 disease who had received 16 weeks or more of previous zidovudine therapy.
Setting: Participating ACTG virology laboratories.
Patients: 187 patients with baseline HIV-1 isolates.
Measurements: Zidovudine susceptibility testing and assays for syncytium-inducing phenotype were done on baseline HIV-1 isolates. Relative hazards for clinical progression or death associated with baseline clinical, virologic, and immunologic factors were determined from Cox proportional hazards regression models.
Results: Compared with other patients, 15% (26 of 170) with isolates showing high-level zidovudine resistance (50% inhibitory zidovudine concentration greater than or equal to 1.0 mu M) had 1.74 times the risk for progressing to a new AIDS-defining event or death (95% CI, 1.00 to 3.03) and 2.78 times the risk for death (CI, 1.21 to 6.39) in analyses that controlled for baseline CD4(+) T-lymphocyte count, syncytium-inducing HIV-1 phenotype, disease stage, and randomized treatment assignment. The clinical benefit of didanosine was not limited to patients with highly zidovudine-resistant baseline HIV-1 isolates.
Conclusions: High-level resistance of HIV-1 to zidovudine predicted more rapid clinical progression and death when adjusted for other factors. However, patients with advanced HIV-1 disease may benefit from a change in monotherapy from zidovudine to didanosine whether high-level HIV-1 resistance to zidovudine is present or absent, and laboratory assessment of zidovudine resistance is not necessary for deciding when to switch monotherapy from zidovudine to didanosine.
C1 HARVARD UNIV,SCH PUBL HLTH,BOSTON,MA 02115.
UNIV ALABAMA,SCH MED,BIRMINGHAM,AL.
VET AFFAIRS MED CTR,BIRMINGHAM,AL.
UNIV COLORADO,HLTH SCI CTR,DENVER,CO.
VET AFFAIRS MED CTR,DENVER,CO.
NIAID,BETHESDA,MD 20892.
UNIV CALIF SAN FRANCISCO,SAN FRANCISCO,CA 94143.
SAN FRANCISCO GEN HOSP,AIDS PROGRAM,SAN FRANCISCO,CA.
UNIV CALIF SAN DIEGO,SAN DIEGO,CA 92103.
VET AFFAIRS MED CTR,LA JOLLA,CA.
HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,BOSTON,MA.
HARVARD UNIV,BETH ISRAEL HOSP,SCH MED,BOSTON,MA.
FU NIAID NIH HHS [AI 27659, AI 32775, AI 29193]
NR 38
TC 231
Z9 232
U1 0
U2 1
PU AMER COLL PHYSICIANS
PI PHILADELPHIA
PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572
SN 0003-4819
J9 ANN INTERN MED
JI Ann. Intern. Med.
PD MAR 15
PY 1995
VL 122
IS 6
BP 401
EP 408
PG 8
WC Medicine, General & Internal
SC General & Internal Medicine
GA QM266
UT WOS:A1995QM26600001
PM 7856987
ER
PT J
AU OHASHI, T
MASUDA, M
RUSCETTI, SK
AF OHASHI, T
MASUDA, M
RUSCETTI, SK
TI INDUCTION OF SEQUENCE-SPECIFIC DNA-BINDING FACTORS BY ERYTHROPOIETIN AND
THE SPLEEN FOCUS-FORMING VIRUS
SO BLOOD
LA English
DT Note
ID SIGNAL-TRANSDUCTION PATHWAY; TYROSINE PHOSPHORYLATION; CYTOKINE
RECEPTORS; INTERFERON-ALPHA; ENVELOPE GENE; GROWTH-FACTOR; PROTEIN;
ERYTHROLEUKEMIA; TRANSCRIPTION; ACTIVATION
AB The signal transduction mechanism of erythropoietin (Epo), which regulates growth and differentiation of erythroid cells, is still unclear. Recent studies showing the activation by various ligands of a group of proteins called Stat (signal transducers and activators of transcription) proteins raised the possibility that such proteins may also be involved in the Epo signal transduction pathway. In this report, we show that Epo induces factors that specifically bind to the sis-inducible element and the gamma response region of the Fc gamma receptor factor I gene in the Epo-dependent mouse erythroleukemia cell line HCD-57. These factors contain phosphotyrosine and antibodies against Stat1 and Stat3 proteins reacted with them. In HCD-57 cells infected with Friend spleen focus-forming virus, which now grow in an Epo-independent manner, the DNA-binding factors were constitutively activated even in the absence of Epo. These results suggest that the factors induced by Epo contain components identical or related to known Stat proteins. It is also suggested that continuous activation of these DNA-binding factors may be responsible for the ability of spleen focus-forming virus to abrogate the Epo-dependence of HCD-57 cells and cause erythroleukemia in susceptible mice. (C) 1995 by The American Society of Hematology.
C1 NCI,FREDERICK CANC RES & DEV CTR,MOLEC ONCOL LAB,FREDERICK,MD 21702.
RI Ohashi, Takashi/C-4671-2012
OI Ohashi, Takashi/0000-0002-3769-4224
NR 47
TC 63
Z9 64
U1 0
U2 2
PU W B SAUNDERS CO
PI PHILADELPHIA
PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA
19106-3399
SN 0006-4971
J9 BLOOD
JI Blood
PD MAR 15
PY 1995
VL 85
IS 6
BP 1454
EP 1462
PG 9
WC Hematology
SC Hematology
GA QN289
UT WOS:A1995QN28900006
PM 7888668
ER
PT J
AU KNIPPING, E
DEBATIN, KM
STRICKER, K
HEILIG, B
EDER, A
KRAMMER, PH
AF KNIPPING, E
DEBATIN, KM
STRICKER, K
HEILIG, B
EDER, A
KRAMMER, PH
TI IDENTIFICATION OF SOLUBLE APO-1 IN SUPERNATANTS OF HUMAN B-CELL AND
T-CELL LINES AND INCREASED SERUM LEVELS IN B-CELL AND T-CELL LEUKEMIAS
SO BLOOD
LA English
DT Article
ID TUMOR-NECROSIS-FACTOR; IMMUNOLOGICAL CROSS-REACTIVITY; GROWTH-FACTOR
RECEPTOR; FACTOR-ALPHA; HUMAN-URINE; LYMPHOCYTIC-LEUKEMIA;
MONOCLONAL-ANTIBODY; MOLECULAR-CLONING; APOPTOSIS GENE; TNF RECEPTOR
AB The cell-surface protein APO-1 is a member of the nerve growth factor (NGF)/tumor necrosis factor (TNF) receptor superfamily. APO-1 mediates apoptosis in susceptible cells upon stimulation with the monoclonal antibody anti-APO-1 or upon binding of its natural ligand. Soluble receptors had previously been identified for most members of the NGF/TNF receptor superfamily. Recently, a soluble form of APO-1 (sAPO-1) was described. We established a sandwich enzyme-linked immunosorbent assay to detect sAPO-1 in culture supernatants of human cell lines and in human sera. sAPO-1 was found in culture supernatants of different human B- and T-cell lines. Molecular weights of sAPO-1 and membrane APO-1 were similar. In addition, in comparison to healthy donors, sera from patients with different high- and low-grade malignant B- and T-cell leukemias and lymphomas contained increased levels of sAPO-1. These findings may have implications for the growth of leukemias and the diagnostic monitoring of individual patients. (C) 1995 by The American Society of Hematology.
C1 GERMAN CANC RES CTR,DIV IMMUNOGENET,TUMORIMMUNOL PROGRAM,D-69120 HEIDELBERG,GERMANY.
UNIV HEIDELBERG,CHILDRENS HOSP,HEMATOL ONCOL SECT,W-6900 HEIDELBERG,GERMANY.
UNIV HEIDELBERG,MED KLIN 5,HEIDELBERG,GERMANY.
NIH,BIOL MODIFIERS PROGRAM,BETHESDA,MD 20892.
BENDER MEDSYST,VIENNA,AUSTRIA.
RI Debatin, Klaus-Michael/J-9704-2014
OI Debatin, Klaus-Michael/0000-0002-8397-1886
NR 64
TC 137
Z9 143
U1 0
U2 0
PU W B SAUNDERS CO
PI PHILADELPHIA
PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA
19106-3399
SN 0006-4971
J9 BLOOD
JI Blood
PD MAR 15
PY 1995
VL 85
IS 6
BP 1562
EP 1569
PG 8
WC Hematology
SC Hematology
GA QN289
UT WOS:A1995QN28900020
PM 7534137
ER
PT J
AU KINGMA, DW
RAFFELD, M
JAFFE, ES
AF KINGMA, DW
RAFFELD, M
JAFFE, ES
TI DIFFERENTIAL-DIAGNOSIS OF CD3(+), CD56(+) T-CELL LEUKEMIAS
SO BLOOD
LA English
DT Letter
ID GAMMA-DELTA; LOCALIZATION; EXPRESSION; SUBSET; BETA
RP KINGMA, DW (reprint author), NCI,PATHOL LAB,BLDG 10,BETHESDA,MD 20892, USA.
NR 8
TC 1
Z9 1
U1 0
U2 0
PU W B SAUNDERS CO
PI PHILADELPHIA
PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA
19106-3399
SN 0006-4971
J9 BLOOD
JI Blood
PD MAR 15
PY 1995
VL 85
IS 6
BP 1675
EP 1676
PG 2
WC Hematology
SC Hematology
GA QN289
UT WOS:A1995QN28900037
PM 7534142
ER
PT J
AU ZARATEOSORNO, A
ROMAN, LN
KINGMA, DW
MENESESGARCIA, A
JAFFE, ES
AF ZARATEOSORNO, A
ROMAN, LN
KINGMA, DW
MENESESGARCIA, A
JAFFE, ES
TI HODGKINS-DISEASE IN MEXICO - PREVALENCE OF EPSTEIN-BARR-VIRUS SEQUENCES
AND CORRELATIONS WITH HISTOLOGIC SUBTYPE
SO CANCER
LA English
DT Article
DE HODGKINS DISEASE; LYMPHOMAS; EPSTEIN-BARR VIRUS; EPIDEMIOLOGY; IN SITU
HYBRIDIZATION; IMMUNOPHENOTYPE
ID REED-STERNBERG CELLS; POLYMERASE CHAIN-REACTION; INSITU HYBRIDIZATION;
BIOTINYLATED PROBES; LYMPH-NODE; B-CELL; EXPRESSION; GENOMES; EBV;
ASSOCIATION
AB Background. The Epstein-Barr virus (EBV) has been linked to several human malignancies, including Hodgkin's disease (HD). In addition, epidemiologic studies have shown differences in HD occurrence in different parts of the world. The authors studied 27 cases of Hodgkin's disease from Mexico to determine the prevalence of EBV in HD in this developing nation.
Methods. The Epstein-Barr virus was investigated using in situ hybridization with the EBER1 probe. Immunohistochemical studies were performed on paraffin sections. Cases from both adult and pediatric age groups were included. Correlations with histologic subtype, clinicopathologic features, and immunophenotype were determined.
Results. Epstein-Barr virus sequences were identified in 18/27 (67%) cases. Positivity correlated with histologic subtype: 0/1 lymphocyte predominant; 6/13 (46%) nodular sclerosis; 7/7 mixed cellularity (MC) (100%); and 5/6 (83%) lymphocyte depleted (LD), The proportion of cases classified as MC and LD (13 of 27) was greater than that found in the United States and other developed countries. The immunophenotypic profile was appropriate for Hodgkin's disease, with all cases of classic Hodgkin's disease positive for CD30 (Ber-H2) and 18 cases expressing CD15. One case of lymphocyte-predominant Hodgkin's disease was CD20 (L26)-positive as were three cases of classic Hodgkin's disease. Patient age ranged from 5 to 65 years, with a median of 29 years.
Conclusions. The EBV is associated highly with HD in Mexico, and this prevalence rate is found in all age groups. A strong correlation between EBV expression and histologic subtype was confirmed, with 92% of MC and LD subtypes found to be positive.
C1 HOSP CENT MIL,DEPT PATHOL,MEXICO CITY,DF,MEXICO.
NCI,HEMATOPATHOL SECT,BETHESDA,MD 20892.
RP ZARATEOSORNO, A (reprint author), INST NACL CANCEROL,DIV CLIN INVEST,AVE SAN FERNANDO 22,MEXICO CITY 14000,DF,MEXICO.
NR 45
TC 39
Z9 40
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0008-543X
J9 CANCER
JI Cancer
PD MAR 15
PY 1995
VL 75
IS 6
BP 1360
EP 1366
DI 10.1002/1097-0142(19950315)75:6<1360::AID-CNCR2820750619>3.0.CO;2-U
PG 7
WC Oncology
SC Oncology
GA QL728
UT WOS:A1995QL72800018
PM 7882287
ER
PT J
AU EYRE, H
SONDIK, E
SMITH, RA
KESSLER, L
AF EYRE, H
SONDIK, E
SMITH, RA
KESSLER, L
TI JOINT MEETING ON THE FEASIBILITY OF A STUDY OF SCREENING PREMENOPAUSAL
WOMEN (40-49 YEARS) FOR BREAST-CANCER - APRIL 20-21, 1994
SO CANCER
LA English
DT Editorial Material
C1 NCI,BETHESDA,MD 20892.
RP EYRE, H (reprint author), AMER CANC SOC,1599 CLIFTON RD NE,ATLANTA,GA 30329, USA.
NR 1
TC 12
Z9 12
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0008-543X
J9 CANCER
JI Cancer
PD MAR 15
PY 1995
VL 75
IS 6
BP 1391
EP 1403
DI 10.1002/1097-0142(19950315)75:6<1391::AID-CNCR2820750623>3.0.CO;2-4
PG 13
WC Oncology
SC Oncology
GA QL728
UT WOS:A1995QL72800022
PM 7882290
ER
PT J
AU SEKIDO, Y
PASS, HI
BADER, S
MEW, DJY
CHRISTMAN, MF
GAZDAR, AF
MINNA, JD
AF SEKIDO, Y
PASS, HI
BADER, S
MEW, DJY
CHRISTMAN, MF
GAZDAR, AF
MINNA, JD
TI NEUROFIBROMATOSIS TYPE-2 (NF2) GENE IS SOMATICALLY MUTATED IN
MESOTHELIOMA BUT NOT IN LUNG-CANCER
SO CANCER RESEARCH
LA English
DT Note
ID FREE DEFINED MEDIUM; MALIGNANT MESOTHELIOMA; CELL-LINES; CLINICAL
SPECIMENS; CHROMOSOME CHANGES; TUMOR SUPPRESSOR; ABNORMALITIES; PROTEIN;
GROWTH
AB We have found 16 of 28 small cell lung cancers, 17 of 31 non-small cell lung cancers, 2 of 3 carcinoids, and 12 of 14 mesotheliomas that had chromosome 22 cytogenetic abnormalities. To determine whether the neurofibromatosis type 2 (NF2) gene located on chromosome 22 participates in the oncogenesis of these malignancies, we studied DNAs from lung cancer cell lines and mesotheliomas using Southern blot analysis and the single-strand conformation polymorphism (SSCP) technique for mutations covering 8 of the 16 known NF2 exons. We detected 7 mutations in 17 mesotheliomas (41%) within the coding region of NF2 but none in 75 lung cancer cell lines (38 small cell lung cancers, 34 non-small cell lung cancers, and 3 carcinoids). These mutations were found to be somatic when normal tissue was available for testing. Four mesothelioma cell lines had relatively large deletions (similar to 10-50 kilobases) in the NF2 gene detectable by Southern blot analysis. Two mesothelioma cell lines had nonsense mutations at codons 57 and 341, respectively. Another mesothelioma obtained as a specimen directly from a patient, had a 10-base pair microdeletion from nucleotide 1004 to nucleotide 1013 causing a frameshift mutation. These results suggest that the NF2 gene participates in the oncogenesis in a subset of mesotheliomas but not in lung cancers.
C1 UNIV TEXAS,SW MED CTR,SIMMONS CANC CTR,DALLAS,TX 75235.
NCI,SURG BRANCH,THORAC ONCOL SECT,BETHESDA,MD 20892.
UNIV CALIF SAN FRANCISCO,DEPT RADIAT ONCOL,SAN FRANCISCO,CA 94143.
FU NCI NIH HHS [P20 CA58220-01]
NR 27
TC 183
Z9 184
U1 0
U2 4
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W.,
PHILADELPHIA, PA 19106
SN 0008-5472
J9 CANCER RES
JI Cancer Res.
PD MAR 15
PY 1995
VL 55
IS 6
BP 1227
EP 1231
PG 5
WC Oncology
SC Oncology
GA QL405
UT WOS:A1995QL40500007
PM 7882313
ER
PT J
AU DABHOLKAR, MD
BERGER, MS
VIONNET, JA
EGWUAGU, C
SILBER, JR
YU, JJ
REED, E
AF DABHOLKAR, MD
BERGER, MS
VIONNET, JA
EGWUAGU, C
SILBER, JR
YU, JJ
REED, E
TI MALIGNANT AND NONMALIGNANT BRAIN-TISSUES DIFFER IN THEIR MESSENGER-RNA
EXPRESSION PATTERNS FOR ERCC1 AND ERCC2
SO CANCER RESEARCH
LA English
DT Article
ID EXCISION REPAIR GENE; A XERODERMA-PIGMENTOSUM; DNA-REPAIR; MOLECULAR
CHARACTERIZATION; CANCER-PATIENTS; CDNA CLONING; HOMOLOGY; YEAST; CELLS
AB Perturbation of the DNA repair process appears to be responsible for the occurrence of a number of human diseases, which are usually associated with a propensity to develop internal malignancies and/or disorders of the central nervous system. We have been interested in the possibility that a subtle abnormality in DNA repair competency might be associated with the transformation of nonmalignant cells to the malignant state. To study this question, we assayed malignant and nonmalignant brain tissues from 19 individuals for mRNA expression levels of the human DNA repair genes ERCC1, ERCC2, and XPAC and for differential splicing of the ERCC1 transcript. We separately compared expression levels of these genes in the following situations: concordance of expression within malignant tissues; concordance of expression within nonmalignant tissues; concordance between malignant and nonmalignant tissues within individuals of the cohort; and concordance of gene expression between two nonmalignant tissue sites within a single individual. Linear regression analyses of mRNA values obtained suggested orderly concordance of these three DNA repair genes in nonmalignant tissues within the patient cohort and an excellent concordance of these genes between two separate biopsy sites from the same individual. In contrast, malignant tissues showed disruption of concordance between the full-length ERCC1 transcript and ERCC2, which have excision and helicase functions, respectively. Furthermore, within the same individuals, malignant tissues were discordant with nonmalignant tissues for ERCC1 and ERCC2, although concordance for XPAC was preserved. These data suggest that one molecular characteristic of human malignancy may be the disruption of the normal relationship between the excision and the helicase functions of the nucleotide excision repair pathway.
C1 NCI, CLIN PHARMACOL BRANCH, MED OVARIAN CANC SECT, BETHESDA, MD 20892 USA.
UNIV WASHINGTON, MED CTR, DEPT NEUROL SURG, SEATTLE, WA 98195 USA.
NEI, IMMUNOL LAB, BETHESDA, MD 20892 USA.
NR 27
TC 45
Z9 46
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
J9 CANCER RES
JI Cancer Res.
PD MAR 15
PY 1995
VL 55
IS 6
BP 1261
EP 1266
PG 6
WC Oncology
SC Oncology
GA QL405
UT WOS:A1995QL40500014
PM 7882319
ER
PT J
AU VIOLA, JJ
AGBARIA, R
WALBRIDGE, S
OSHIRO, EM
JOHNS, DG
KELLEY, JA
OLDFIELD, EH
RAM, Z
AF VIOLA, JJ
AGBARIA, R
WALBRIDGE, S
OSHIRO, EM
JOHNS, DG
KELLEY, JA
OLDFIELD, EH
RAM, Z
TI IN-SITU CYCLOPENTENYL CYTOSINE INFUSION FOR THE TREATMENT OF
EXPERIMENTAL BRAIN-TUMORS
SO CANCER RESEARCH
LA English
DT Article
ID TRIPHOSPHATE; ANTITUMOR
AB Cyclopentenylcytosine (CPEC; NSC 375575) is a pyrimidine nucleoside analogue that has potent antitumor effects when tested in vitro and also when tested in experimental tumors outside the central nervous system. CPEC exerts its antiproliferative effect through inhibition of CTP synthetase and consequent depletion of CTP and dCTP pools required for cell replication. Due to its poor penetration of the blood-brain barrier, CPEC has failed to demonstrate therapeutic efficacy in experimental brain tumors after systemic administration. We therefore examined the in vivo activation, distribution, and antitumor effect of CPEC after long-term regional infusion of the drug directly into experimental brain tumors in rats.
HPLC analysis of CPEC incubated with homogenized human brain and brain tumor tissue showed minimal degradation of the drug over 24 h. Analysis of rat cerebral 9L gliosarcoma infused with tritium-labeled CPEC demonstrated intratunoral accumulation of the active metabolite CPEC-triphosphate and concomitant depletion of CTP to a much greater extent in tumor tissue than in the adjacent brain. Tumor tissue UTP also decreased, but no significant effects on other ribonucleoside hiphosphates were detected. Only trace amounts (<1%) of CPEC and its metabolites reached peripheral sites, including the liver and kidneys, after intratumoral infusion. Rats treated with continuous intratumoral infusion of CPEC for 4 weeks using s.c. implanted osmotic pumps survived significantly longer than control rats receiving intratumoral saline or i.p. CPEC (P < 0.0001). Long-term intratumoral infusion of CPEC was not associated with any detectable toxicity.
Our results support the feasibility of using intratumoral administration of CPEC as a regional therapy for malignant brain tumors.
C1 NINCDS,SURG NEUROL BRANCH,BETHESDA,MD 20892.
NCI,DEV THERAPEUT PROGRAM,BETHESDA,MD 20892.
NR 15
TC 27
Z9 29
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W.,
PHILADELPHIA, PA 19106
SN 0008-5472
J9 CANCER RES
JI Cancer Res.
PD MAR 15
PY 1995
VL 55
IS 6
BP 1306
EP 1309
PG 4
WC Oncology
SC Oncology
GA QL405
UT WOS:A1995QL40500022
PM 7882327
ER
PT J
AU FUJIMORI, A
HARKER, WG
KOHLHAGEN, G
HOKI, Y
POMMIER, Y
AF FUJIMORI, A
HARKER, WG
KOHLHAGEN, G
HOKI, Y
POMMIER, Y
TI MUTATION AT THE CATALYTIC SITE OF TOPOISOMERASE-I IN CEM/C2, A HUMAN
LEUKEMIA-CELL LINE RESISTANT TO CAMPTOTHECIN
SO CANCER RESEARCH
LA English
DT Article
ID HAMSTER DC3F CELLS; DNA TOPOISOMERASE; DRUG CAMPTOTHECIN; POINT
MUTATION; LUNG-CANCER; GENE; IDENTIFICATION; CLONING; CDNA; MECHANISM
AB We developed previously a resistant cell line, CEM/C2, from the human leukemia cell line CCRF-CEM by stepwise selection in camptothecin. This cell line is 974-fold more resistant to camptothecin than parental cells. Resistance is only partially explained by 2-fold reductions in topoisomerase I protein and mRNA levels. We further investigated biochemical and molecular features of topoisomerase I in the resistant cell line. Sequence analyses of the top1 cDNA from CEM/C2 identified mutations corresponding to two amino acid substitutions, Met370Thr and Asn722Ser. Asn722Ser is next to the catalytic Tyr723 in a region highly conserved among type I eukargotic DNA topoisomerases. Recombinant top1 with the corresponding substitution was found to be catalytically active and resistant to camptothecin. These results indicate that camptothecin resistance of CEM/C2 is due to the mutation Asn722Ser and strongly suggest that the asparagine immediately flanking the catalytic tyrosine is important for the camptothecin action.
C1 NCI, DIV CANC TREATMENT, MOLEC PHARMACOL LAB, BETHESDA, MD 20892 USA.
DEPT VET AFFAIRS MED CTR, SALT LAKE CITY, UT 84148 USA.
NR 39
TC 147
Z9 150
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD MAR 15
PY 1995
VL 55
IS 6
BP 1339
EP 1346
PG 8
WC Oncology
SC Oncology
GA QL405
UT WOS:A1995QL40500028
PM 7882333
ER
PT J
AU PANZA, JA
GARCIA, CE
KILCOYNE, CM
QUYYUMI, AA
CANNON, RO
AF PANZA, JA
GARCIA, CE
KILCOYNE, CM
QUYYUMI, AA
CANNON, RO
TI IMPAIRED ENDOTHELIUM-DEPENDENT VASODILATION IN PATIENTS WITH
ESSENTIAL-HYPERTENSION - EVIDENCE THAT NITRIC-OXIDE ABNORMALITY IS NOT
LOCALIZED TO A SINGLE SIGNAL-TRANSDUCTION PATHWAY
SO CIRCULATION
LA English
DT Article
DE ENDOTHELIUM; HYPERTENSION; BRADYKININ; ACETYLCHOLINE; PROTEINS
ID PROTEIN-LINKED RECEPTORS; RELAXING FACTOR; VASCULAR RELAXATION;
CORONARY-ARTERIES; PULMONARY-ARTERY; SMOOTH-MUSCLE; L-ARGININE;
PHOSPHOINOSITIDE TURNOVER; MUSCARINIC RECEPTOR; ALPHA-SUBUNITS
AB Background Patients with essential hypertension have abnormal endothelium-dependent vascular relaxation, largely related to reduced bioactivity of nitric oxide (NO). The purpose of the present investigation was to determine whether this defect is due to a deficit at the specific intracellular signal-transduction pathway level or is a consequence of a more generalized endothelial abnormality.
Methods and Results The responses of the forearm vasculature to acetylcholine and bradykinin (endothelium-dependent agents that act through different signal transduction pathways) and to sodium nitroprusside (a direct dilator of vascular smooth muscle) were studied in 10 hypertensive patients (5 men, 5 women; aged 48+/-9 years old [mean+/-SD]) and 12 control subjects (6 men, 6 women; aged 48+/-7 years old). To determine the contribution of NO to bradykinin-induced vasodilation, the vascular responses to bradykinin were also measured after administration of N-G-monomethyl-L-arginine, an arginine analogue that inhibits the synthesis of NO. Drugs were infused into the brachial artery, and forearm blood flow was measured by strain-gauge plethysmography. The response to acetylcholine was significantly blunted in hypertensive patients (maximal blood flow, 7.5+/-2 versus 16.6+/-8 mL . min(-1). 100 mL(-1) in control subjects [mean+/-SD]; P<.005). Similarly, the vasodilator effect of bradykinin was significantly reduced in hypertensive patients compared with control subjects (maximal blood flow, 8.7+/-2 versus 15.8+/-6 mL . min(-1). 100 mL(-1) in control subjects; P<.005). A significant correlation was found between the maximal blood flow with acetylcholine and that with bradykinin (r=.89). No significant differences were found between the two groups for vascular response to sodium nitroprusside. N-G-monomethyl-L-arginine significantly blunted the response to bradykinin in control subjects (maximal blood flow decreased from 15.8+/-6 to 10.1+/-2 mL . min(-1). 100 mL(-1), P<.003). In contrast, inhibition of NO synthesis did not modify the response to bradykinin in hypertensive patients (maximal blood flow, 8.7+/-2 and 8.5+/-3 before and during infusion of N-G-monomethyl-L-arginine, respectively; P=NS). As a consequence, the response to bradykinin after inhibition of NO synthesis was not significantly different between the two groups.
Conclusions Patients with essential hypertension have impaired endothelium-dependent vasodilator responses to both acetylcholine and bradykinin. These findings indicate that the endothelial dysfunction in this condition is not related to a specific defect of a single intracellular signal-transduction pathway and suggest a more generalized abnormality of endothelial vasodilator function.
RP PANZA, JA (reprint author), NHLBI, CARDIOL BRANCH, BLDG 10, ROOM 7B-15, BETHESDA, MD 20892 USA.
NR 58
TC 275
Z9 286
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD MAR 15
PY 1995
VL 91
IS 6
BP 1732
EP 1738
PG 7
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA QL458
UT WOS:A1995QL45800017
PM 7882481
ER
PT J
AU GARDIN, JM
SISCOVICK, D
ANTONCULVER, H
LYNCH, JC
SMITH, VE
KLOPFENSTEIN, HS
BOMMER, WJ
FRIED, L
OLEARY, D
MANOLIO, TA
AF GARDIN, JM
SISCOVICK, D
ANTONCULVER, H
LYNCH, JC
SMITH, VE
KLOPFENSTEIN, HS
BOMMER, WJ
FRIED, L
OLEARY, D
MANOLIO, TA
TI SEX, AGE, AND DISEASE AFFECT ECHOCARDIOGRAPHIC LEFT-VENTRICULAR MASS AND
SYSTOLIC FUNCTION IN THE FREE-LIVING ELDERLY - THE CARDIOVASCULAR HEALTH
STUDY
SO CIRCULATION
LA English
DT Article
DE ECHOCARDIOGRAPHY; MULTICENTER STUDY; AGING; CARDIOVASCULAR DISEASES;
VENTRICLES
ID HEART-DISEASE; POPULATION; ADULTS; IMPACT
AB Background Left ventricular (LV) hypertrophy, as measured by M-mode echocardiography, is an independent predictor of mortality and/or morbidity from coronary heart disease (CHD). LV global and segmental systolic dysfunction also have been associated with myocardial ischemia and cardiovascular morbidity and mortality. Echocardiographic data, especially two-dimensional, have not been available previously from multicenter-based studies of the elderly. This report describes the distribution and relation at baseline of echocardiographic LV mass and global and segmental LV wall motion to age, sex, and clinical disease category in the Cardiovascular Health Study (CHS), a cohort of 5201 men and women (4850 white) 65 years of age and older.
Methods and Results M-mode LV mass adjusted for body weight increased modestly with age (P<.0001), increasing less than one gram per year increase in age for both men and women. After adjustment for weight, LV mass was significantly greater in men than in women and in participants with clinical CHD compared with participants with neither clinical heart disease nor hypertension (both P<.001). Across all CHS age subgroups, the difference in weight-adjusted LV mass by sex was greater in magnitude than the difference related to clinical CHD. M-mode measurements of LV mass could not be made in 34% of CHS participants, and this was highly related to age (29% in the 65 to 69 year versus 50% in the 85+ year age group, P<.001) and other risk factors. In participants with clinical CHD and with neither clinical heart disease nor hypertension, LV ejection fraction and segmental wall motion abnormalities were more prevalent in men than women (all P<.001). Of interest, 0.5% of men and 0.4% of women with neither clinical heart disease nor hypertension had LV segmental wall motion abnormalities, suggesting silent disease, compared with 26% of men and 10% of women in the clinical CHD group (P<.0001). Multivariate analyses revealed male sex and presence of clinical CHD (both P<.001) to be independent predictors of LV akinesis or dyskinesis.
Conclusions Significant baseline relations were detected between differences in sex, prevalent disease status, and echocardiographic measurements of LV mass and systolic function in the CHS cohort. Age was weakly associated with LV mass measurements and LV ejection fraction abnormalities. These relations should be considered in evaluating the preclinical and clinical effects of CHD risk factors in the elderly.
C1 UNIV CALIF IRVINE,DEPT MED,DIV CARDIOL,IRVINE,CA.
UNIV CALIF IRVINE,DEPT MED,DIV EPIDEMIOL,IRVINE,CA.
UNIV WASHINGTON,HARBORVIEW MED CTR,DEPT MED,SEATTLE,WA.
UNIV WASHINGTON,HARBORVIEW MED CTR,DEPT EPIDEMIOL,SEATTLE,WA.
UNIV WASHINGTON,HARBORVIEW MED CTR,DEPT BIOSTAT,SEATTLE,WA.
ALBANY MED COLL,DIV CARDIOL,ALBANY,NY.
BOWMAN GRAY SCH MED,DEPT MED,DIV CARDIOL,WINSTON SALEM,NC.
UNIV CALIF DAVIS,DEPT MED,DIV CARDIOL,SACRAMENTO,CA.
JOHNS HOPKINS MED INST,DEPT MED,BALTIMORE,MD.
JOHNS HOPKINS MED INST,DEPT EPIDEMIOL,BALTIMORE,MD.
GEISINGER MED CTR,DEPT RADIOL,DANVILLE,PA.
NHLBI,DIV EPIDEMIOL & CLIN APPLICAT,BETHESDA,MD.
FU NHLBI NIH HHS [HC-85086, N01-HC85079]
NR 24
TC 181
Z9 185
U1 0
U2 1
PU AMER HEART ASSOC
PI DALLAS
PA 7272 GREENVILLE AVENUE, DALLAS, TX 75231-4596
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD MAR 15
PY 1995
VL 91
IS 6
BP 1739
EP 1748
PG 10
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA QL458
UT WOS:A1995QL45800018
PM 7882482
ER
PT J
AU YAMAGUCHIIWAI, Y
DANCIS, A
KLAUSNER, RD
AF YAMAGUCHIIWAI, Y
DANCIS, A
KLAUSNER, RD
TI AFT1 - A MEDIATOR OF IRON-REGULATED TRANSCRIPTIONAL CONTROL IN
SACCHAROMYCES-CEREVISIAE
SO EMBO JOURNAL
LA English
DT Article
DE FERRIC REDUCTASE; IRON; TRANSCRIPTION; TRANSPORT
ID ELEMENT BINDING-PROTEIN; FERRIC REDUCTASE; MOLECULAR CHARACTERIZATION;
SIDEROPHORE BIOSYNTHESIS; USTILAGO-MAYDIS; MAMMALIAN-CELLS; GENE; YEAST;
RNA; EXPRESSION
AB Using a scheme for selecting mutants of Saccharomyces cerevisiae with abnormalities of iron metabolism, we have identified a gene, AFT1, that mediates the control of iron uptake. AFT1 encodes a 78 kDa protein with a highly basic amino terminal domain and a glutamine-rich C-terminal domain, reminiscent of transcriptional activators. The protein also contains an amino terminal and a C-terminal region with 10% His residues. A dominant mutant allele of this gene, termed AFT1-1(up), results in high levels of ferric reductase and ferrous iron uptake that are not repressed by exogenous iron. The increased iron uptake is associated with enhanced susceptibility to iron toxicity. These effects may be explained by the failure of iron to repress transcription of FRE1, FRE2 and FET3. FRE1 and FRE2 encode plasma membrane ferric reductases, obligatory for ferric iron assimilation, and FET3 encodes a copper-dependent membrane-associated oxidase required for ferrous iron uptake. Conversely, a strain with interruption of the AFT1 gene manifests low ferric reductase and ferrous iron uptake and is susceptible to iron deprivation, because of deficient expression of FRE1 and negligible expression of FRE2 and FET3. Thus, AFT1 functions to activate transcription of target genes in response to iron deprivation and thereby plays a central role in iron homeostasis.
C1 NICHHD, CELL BIOL & METAB BRANCH, BETHESDA, MD 20892 USA.
NR 41
TC 223
Z9 232
U1 1
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0261-4189
EI 1460-2075
J9 EMBO J
JI Embo J.
PD MAR 15
PY 1995
VL 14
IS 6
BP 1231
EP 1239
PG 9
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QR037
UT WOS:A1995QR03700019
PM 7720713
ER
PT J
AU GARNER, MM
RAU, DC
AF GARNER, MM
RAU, DC
TI WATER RELEASE ASSOCIATED WITH SPECIFIC BINDING OF GAL REPRESSOR
SO EMBO JOURNAL
LA English
DT Article
DE GAL REPRESSOR; HYDRATION; OSMOTIC STRESS; PROTEIN-DNA INTERACTIONS
ID PROTEIN-DNA INTERACTIONS; MOBILITY-SHIFT ASSAY; STABILIZATION;
SOLVATION; ELEMENTS; INVITRO; COMPLEX
AB Water release coupled to the association of gal repressor with DNA is measured from the sensitivity of the binding constant to the solution osmotic pressure, using neutral solutes that are typically excluded from polar protein and DNA surfaces. Differences in water release for binding of repressor to different sequences are linked with differences in specificity and binding energies. With sucrose, the specific binding of repressor to operator sequences is accompanied by the release of 130 water molecules. No water release is seen for the weak, non-specific binding of repressor to poly(dI-dC).(dI-dC). A difference in the release of six water molecules is seen even for the binding of gal repressor to two different operator sequences that differ in affinity by only a factor of two.
C1 NIDDK,OFF INTRAMURAL RES,BETHESDA,MD 20892.
NICHHD,THEORET & PHYS BIOL LAB,BETHESDA,MD 20892.
NR 33
TC 87
Z9 89
U1 0
U2 1
PU OXFORD UNIV PRESS UNITED KINGDOM
PI OXFORD
PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP
SN 0261-4189
J9 EMBO J
JI Embo J.
PD MAR 15
PY 1995
VL 14
IS 6
BP 1257
EP 1263
PG 7
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QR037
UT WOS:A1995QR03700022
PM 7720716
ER
PT J
AU ANGLADE, E
SULLIVAN, D
NUSSENBLATT, R
CSAKY, K
AF ANGLADE, E
SULLIVAN, D
NUSSENBLATT, R
CSAKY, K
TI PRODUCTION OF AN IMMUNOADHESIN WITH ANTAGONIST ACTIVITY TOWARDS THE
MURINE INTERLEUKIN-2 RECEPTOR
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,IMMUNOL LAB,BETHESDA,MD 20892.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S542
EP S542
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91502515
ER
PT J
AU AYYAGARI, R
SMITH, RJH
POLYJMEROPOLOUS, M
DAIGER, S
PELIAS, MZ
WOZENCRAFT, L
KAISERKUPFER, M
NESTOROWICZ, A
PERMUTT, A
LEE, Y
HEJTMANCIK, JF
AF AYYAGARI, R
SMITH, RJH
POLYJMEROPOLOUS, M
DAIGER, S
PELIAS, MZ
WOZENCRAFT, L
KAISERKUPFER, M
NESTOROWICZ, A
PERMUTT, A
LEE, Y
HEJTMANCIK, JF
TI A YAC CONTIG ENCOMPASSING THE USHIC LOCUS ON THE SHORT ARM OF
CHROMOSOME-11
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
UNIV IOWA,DEPT OTOLARYNGOL,IOWA CITY,IA 52242.
NIH,NATL CTR HUMAN GENOME RES,BETHESDA,MD 20892.
UNIV TEXAS,HLTH SCI CTR,HOUSTON,TX 77225.
LOUISIANA STATE UNIV,MED CTR,DEPT BIOMETRY & GENET,NEW ORLEANS,LA 70112.
WASHINGTON UNIV,DEPT INTERNAL MED,ST LOUIS,MO 63130.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S1045
EP S1045
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91504822
ER
PT J
AU BERNSTEIN, SL
BORST, DE
WONG, P
AF BERNSTEIN, SL
BORST, DE
WONG, P
TI CHARACTERIZATION OF A HUMAN FOVEAL PRIMARY CDNA LIBRARY AND ISOLATION OF
CANDIDATE GENES FOR MACULAR DYSTROPHIES
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S621
EP S621
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91502852
ER
PT J
AU BLAKE, DA
YU, H
NEGRE, E
ROBERTS, DD
VOGEL, T
AF BLAKE, DA
YU, H
NEGRE, E
ROBERTS, DD
VOGEL, T
TI INTEGRIN-DEPENDENT MIGRATION OF HUMAN AND BOVINE CORNEAL
ENDOTHELIAL-CELLS
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 TULANE UNIV,SCH MED,DEPT OPHTHALMOL,NEW ORLEANS,LA 70112.
NCI,PATHOL LAB,BETHESDA,MD 20892.
BIOTECHNOL GEN LTD,REHOVOT,ISRAEL.
RI Roberts, David/A-9699-2008
OI Roberts, David/0000-0002-2481-2981
NR 1
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S294
EP S294
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91501353
ER
PT J
AU BOATRIGHT, JH
BORST, DE
LIN, ZY
SI, JS
BHATI, M
PATEL, D
BRUNO, J
NICKERSON, JM
AF BOATRIGHT, JH
BORST, DE
LIN, ZY
SI, JS
BHATI, M
PATEL, D
BRUNO, J
NICKERSON, JM
TI FUNCTIONAL-CHARACTERIZATION OF CIS-ACTING REGULATORY ELEMENTS OF THE
IRBP GENE PROMOTER REGION
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 EMORY UNIV,SCH MED,ATLANTA,GA 30322.
NEI,BETHESDA,MD 20892.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S123
EP S123
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91500599
ER
PT J
AU BORRAS, T
ZIGLER, JS
AF BORRAS, T
ZIGLER, JS
TI ADENOVIRUS-MEDIATED GENE-TRANSFER INTO WHOLE MONKEY LENS IN
ORGAN-CULTURE
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,MECHANISMS OCULAR DIS LAB,BETHESDA,MD 20892.
NR 2
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S844
EP S844
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91503872
ER
PT J
AU CARPER, DA
OLD, SE
ELKABBANI, O
HOHMAN, TC
AF CARPER, DA
OLD, SE
ELKABBANI, O
HOHMAN, TC
TI STRUCTURE-FUNCTION STUDIES OF HUMAN ALDOSE REDUCTASE
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 WYETH AVERST LAB,PRINCETON,NJ.
NEI,BETHESDA,MD 20892.
UNIV ALABAMA,BIRMINGHAM,AL 35294.
NR 2
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S821
EP S821
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91503792
ER
PT J
AU CARUSO, RC
KAISERKUPFER, MI
GOODMAN, LA
ZUJEWSKI, JA
OSHAUGNESSY, JA
AF CARUSO, RC
KAISERKUPFER, MI
GOODMAN, LA
ZUJEWSKI, JA
OSHAUGNESSY, JA
TI EFFECTS OF FENRETINIDE (4-HPR) ON DARK-ADAPTATION
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NCI,BETHESDA,MD 20892.
NEI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S923
EP S923
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91504236
ER
PT J
AU CHAN, CC
FACTOR, V
LI, Q
NAGY, P
PENG, B
THORGEIRSSON, S
AF CHAN, CC
FACTOR, V
LI, Q
NAGY, P
PENG, B
THORGEIRSSON, S
TI THE EYES OF TGF-BETA-1 TRANSGENIC MICE - HISTOLOGY AND IMMUNE-RESPONSES
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,IMMUNOL LAB,BETHESDA,MD 20892.
NCI,EXPTL CARCINOGENESIS LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S202
EP S202
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91500933
ER
PT J
AU CHEN, PW
SALGALLER, ML
ROSENBERG, SA
MURRAY, T
KSANDER, BR
AF CHEN, PW
SALGALLER, ML
ROSENBERG, SA
MURRAY, T
KSANDER, BR
TI INCREASED EXPRESSION OF GENES ENCODING TUMOR-SPECIFIC ANTIGENS IN OCULAR
MELANOMA - POTENTIAL TARGETS FOR IMMUNOTHERAPY
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 SCHEPENS EYE RES INST,BOSTON,MA.
NCI,SURG BRANCH,BETHESDA,MD 20892.
UNIV MIAMI,DEPT OPHTHALMOL,MIAMI,FL 33152.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S221
EP S221
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91501008
ER
PT J
AU CHEPELINSKY, AB
PARKERWILSON, DM
KUANG, K
FISCHBARG, J
AF CHEPELINSKY, AB
PARKERWILSON, DM
KUANG, K
FISCHBARG, J
TI A NEW WATER CHANNEL EXPRESSED IN CORNEAL ENDOTHELIAL-CELLS
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
COLUMBIA UNIV COLL PHYS & SURG,NEW YORK,NY 10032.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S7
EP S7
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91500031
ER
PT J
AU CHEUNG, MK
WALTON, RC
CHAN, CC
PARKS, DJ
WHITCUP, SM
NUSSENBLATT, RB
AF CHEUNG, MK
WALTON, RC
CHAN, CC
PARKS, DJ
WHITCUP, SM
NUSSENBLATT, RB
TI SUBRETINAL FIBROSIS IN VOGT-KOYANAGI-HARADA SYNDROME
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,IMMUNOL LAB,BETHESDA,MD 20892.
NEI,CLIN BRANCH,BETHESDA,MD 20892.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S782
EP S782
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91503604
ER
PT J
AU CHOUDHURY, A
CHALAM, KV
PAKALNIS, VA
CASPI, RR
BOWERS, WE
AF CHOUDHURY, A
CHALAM, KV
PAKALNIS, VA
CASPI, RR
BOWERS, WE
TI PROCESSING AND PRESENTATION OF S-ANTIGEN BY RAT CHOROIDAL DENDRITIC
CELLS
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 UNIV S CAROLINA,SCH MED,DEPT MICROBIOL & IMMUNOL,COLUMBIA,SC 29208.
UNIV S CAROLINA,SCH MED,DEPT OPHTHALMOL,COLUMBIA,SC 29208.
NEI,IMMUNOL LAB,BETHESDA,MD 20892.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S543
EP S543
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91502520
ER
PT J
AU CHRISTOFORIDIS, JB
CARUSO, RC
CHOI, R
KAISERKUPFER, MI
AF CHRISTOFORIDIS, JB
CARUSO, RC
CHOI, R
KAISERKUPFER, MI
TI THE VOLUME OF THE VISUAL-FIELD ASSESSED WITH KINETIC PERIMETRY
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,OPHTHALM GENET & CLIN SERV BRANCH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S451
EP S451
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91502071
ER
PT J
AU CHUNG, H
LI, Q
WHITCUP, SM
NUSSENBLATT, RB
CHAN, CC
AF CHUNG, H
LI, Q
WHITCUP, SM
NUSSENBLATT, RB
CHAN, CC
TI EXPRESSION OF TGF-BETA-1 MESSENGER-RNA ON IRIDECTOMY SPECIMENS FROM
PATIENTS WITH UVEITIS
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
SEOUL NATL UNIV,COLL MED,DEPT OPHTHALMOL,SEOUL,SOUTH KOREA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S101
EP S101
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91500486
ER
PT J
AU CORDAHI, GJ
PEARSON, PA
MARTIN, DF
SCHMEISSER, ET
NUSSENBLATT, RB
ASHTON, P
AF CORDAHI, GJ
PEARSON, PA
MARTIN, DF
SCHMEISSER, ET
NUSSENBLATT, RB
ASHTON, P
TI TOXICITY OF SUSTAINED-RELEASE CYCLOSPORINE-A IN NONHUMAN PRIMATE EYES
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 UNIV KENTUCKY,DEPT OPHTHALMOL,LEXINGTON,KY 40506.
EMORY UNIV,DEPT OPHTHALMOL,ATLANTA,GA 30322.
NEI,BETHESDA,MD 20892.
TUFTS UNIV,DEPT OPHTHALMOL,BOSTON,MA 02111.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S539
EP S539
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91502501
ER
PT J
AU COURTNEY, SM
CLARK, VP
KARNI, A
MARTIN, A
UNGERLEIDER, LG
HAXBY, JV
AF COURTNEY, SM
CLARK, VP
KARNI, A
MARTIN, A
UNGERLEIDER, LG
HAXBY, JV
TI FMRI STUDIES REVEAL THAT ATTENTION, WORKING-MEMORY, AND LEARNING
MODULATE ACTIVITY IN HUMAN VISUAL NEURAL SYSTEMS
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NIMH,BETHESDA,MD 20892.
RI martin, alex/B-6176-2009
NR 0
TC 1
Z9 1
U1 0
U2 1
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S612
EP S612
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91502823
ER
PT J
AU CRABBE, MJC
CHEPELINSKY, AB
DILSIZ, N
AF CRABBE, MJC
CHEPELINSKY, AB
DILSIZ, N
TI IN-VIVO INSERTION OF RAT LENS MIP INTO THE ESCHERICHIA-COLI CYTOPLASMIC
MEMBRANE
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 UNIV READING,DEPT MICROBIOL,READING RG6 2AH,BERKS,ENGLAND.
NEI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S198
EP S198
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91500920
ER
PT J
AU DASTGHEIB, K
LI, Q
CHAN, CC
ROBERGE, FG
CSAKY, K
GREEN, WR
AF DASTGHEIB, K
LI, Q
CHAN, CC
ROBERGE, FG
CSAKY, K
GREEN, WR
TI VASCULAR ENDOTHELIAL GROWTH-FACTOR (VEGF) IN NEOVASCULAR AGE-RELATED
MACULAR DEGENERATION
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
GRAD HOSP PHILADELPHIA,PHILADELPHIA,PA 19146.
JOHNS HOPKINS MED INST,WILNER OPHTHALMOL INST,BALTIMORE,MD 21205.
NR 0
TC 8
Z9 8
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S102
EP S102
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91500493
ER
PT J
AU DEREVIANIK, NL
VINORES, SA
PENG, B
MAHLOW, J
CHIU, C
CAMPOCHIARO, PA
CHAN, CC
AF DEREVIANIK, NL
VINORES, SA
PENG, B
MAHLOW, J
CHIU, C
CAMPOCHIARO, PA
CHAN, CC
TI EFFECTS OF CYCLOSPORINE-A (CSA), DEXAMETHASONE, AND THROMBOXANE
SYNTHETASE INHIBITOR (CGS-13080) ON BLOOD-RETINAL BARRIER BREAKDOWN IN
EXPERIMENTAL AUTOIMMUNE UVEORETINITIS - AN ULTRASTRUCTURAL-STUDY
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 JOHNS HOPKINS UNIV,SCH MED,WILMER OPHTHALMOL INST,BALTIMORE,MD 21205.
NEI,IMMUNOL LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S544
EP S544
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91502524
ER
PT J
AU DILLON, J
GAILLARD, EA
BILSKI, P
CHIGNELL, C
RESZKA, K
AF DILLON, J
GAILLARD, EA
BILSKI, P
CHIGNELL, C
RESZKA, K
TI THE PHOTOCHEMISTRY OF THE RETINOIDS AS STUDIED BY STEADY-STATE AND
PULSED METHODS
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 COLUMBIA UNIV,DEPT OPHTHALMOL,NEW YORK,NY 10027.
UNIV ROCHESTER,DEPT CHEM,ROCHESTER,NY 14627.
NIEHS,MOLEC BIOPHYS LAB,RES TRIANGLE PK,NC 27709.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S124
EP S124
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91500603
ER
PT J
AU DUNCAN, T
PALMER, K
CHADER, GJ
WIGGERT, B
AF DUNCAN, T
PALMER, K
CHADER, GJ
WIGGERT, B
TI A PUTATIVE RETINAL-PIGMENT EPITHELIAL-CELL SURFACE-RECEPTOR FOR
INTERPHOTORECEPTOR RETINOID-BINDING PROTEIN (IRBP)
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,RETINAL CELL & MOLEC BIOL LAB,BETHESDA,MD 20892.
NR 0
TC 3
Z9 3
U1 0
U2 1
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S122
EP S122
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91500593
ER
PT J
AU EGWUAGU, CE
OHTAKAMARAYUMA, C
MAHDI, R
SMITH, J
CHEPELINSKY, AB
AF EGWUAGU, CE
OHTAKAMARAYUMA, C
MAHDI, R
SMITH, J
CHEPELINSKY, AB
TI CONSTITUTIVE SYNTHESIS OF GAMMA-INTERFERON IN THE LENS OF TRANSGENIC
MICE ALTERS THE PATTERN OF LENS GENE-EXPRESSION
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S879
EP S879
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91504016
ER
PT J
AU FERRIS, FL
AF FERRIS, FL
TI ANTIOXIDANTS AND THE EYE - CLINICAL-TRIALS
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,DIV BIOMETRY & EPIDEMIOL,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S193
EP S193
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91500901
ER
PT J
AU FONG, DS
MYERS, FL
SEGAL, PP
HUBBARD, LM
DAVIS, MD
FERRIS, FL
AF FONG, DS
MYERS, FL
SEGAL, PP
HUBBARD, LM
DAVIS, MD
FERRIS, FL
TI SUBRETINAL FIBROSIS IN PATIENTS WITH DIABETIC-RETINOPATHY
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 UNIV WISCONSIN,CTGR FUNDUS PHOTOGRAPH READING,MADISON,WI 53706.
NEI,CLIN TRIALS BRANCH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S819
EP S819
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91503786
ER
PT J
AU FREDERIKSE, P
PIATIGORSKY, J
AF FREDERIKSE, P
PIATIGORSKY, J
TI H2O2 AND UV STRESS INDUCTION OF AP-1 BINDING IN VERTEBRATE LENSES
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,LMDB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S843
EP S843
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91503869
ER
PT J
AU FUKUSHIMA, A
LAI, JC
SHILOACH, J
GUEZCROSIER, Y
WHITCUP, SM
NUSSENBLATT, RB
GERY, I
AF FUKUSHIMA, A
LAI, JC
SHILOACH, J
GUEZCROSIER, Y
WHITCUP, SM
NUSSENBLATT, RB
GERY, I
TI PROMISCUOUS EPITOPES OF HUMAN S-ANTIGEN (H-SAG) STIMULATE LYMPHOCYTES
WITH DIFFERENT MHC RESTRICTIONS
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
NIDDK,BETHESDA,MD.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S543
EP S543
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91502519
ER
PT J
AU FUREYKURKJIAN, M
PIETRINI, P
GRAFFRADFORD, NR
ALEXANDER, GE
FREO, U
GRADY, CL
DANI, A
MENTIS, M
SZCZEPANIK, J
HODOS, W
SCHAPIRO, MB
AF FUREYKURKJIAN, M
PIETRINI, P
GRAFFRADFORD, NR
ALEXANDER, GE
FREO, U
GRADY, CL
DANI, A
MENTIS, M
SZCZEPANIK, J
HODOS, W
SCHAPIRO, MB
TI CORTICAL VISUAL IMPAIRMENT AS AN EARLY AND PROMINENT SIGN IN
ALZHEIMER-DISEASE (AD) - A NEUROPSYCHOLOGICAL AND POSITRON EMISSION
TOMOGRAPHY (PET) STUDY
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NIA,NEUROSCI LAB,BETHESDA,MD 20892.
MAYO CLIN,DEPT NEUROL,JACKSONVILLE,FL.
UNIV MARYLAND,DEPT PSYCHOL,COLLEGE PK,MD 20742.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S682
EP S682
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91503122
ER
PT J
AU GARLAND, DL
DUGLASTABOR, Y
DATILES, MB
ZIGLER, JS
MAGNO, B
AF GARLAND, DL
DUGLASTABOR, Y
DATILES, MB
ZIGLER, JS
MAGNO, B
TI ANALYSIS OF HUMAN LENS PROTEINS DURING FIBER CELL MATURATION
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
NR 0
TC 2
Z9 3
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S822
EP S822
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91503795
ER
PT J
AU GEORGE, RK
VISTICA, BP
NUSSENBLATT, RB
WHITCUP, SM
AF GEORGE, RK
VISTICA, BP
NUSSENBLATT, RB
WHITCUP, SM
TI HIGH SERUM LEVELS OF SOLUBLE ICAM-1 (CD54) IN UVEITIS PATIENTS PREDICT
UNDERLYING SYSTEMIC-DISEASE
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S536
EP S536
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91502489
ER
PT J
AU GOMES, JAP
SCHWARTING, R
RIZZO, L
ARBIZO, V
DONOSO, LA
DUA, HS
AF GOMES, JAP
SCHWARTING, R
RIZZO, L
ARBIZO, V
DONOSO, LA
DUA, HS
TI MECHANISM OF EXPRESSION OF THE HUMAN MUCOSAL LYMPHOCYTE ANTIGEN (HML-1)
IN CONJUNCTIVA ASSOCIATED LYMPHOID-TISSUE (CALT)
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 DEPT SANTA CASA OPHTHALMOL,SANTA CASA,SP,BRAZIL.
WILLS EYE HOSP & RES INST,PHILADELPHIA,PA 19107.
THOMAS JEFFERSON UNIV,PHILADELPHIA,PA 19107.
UNIV NOTTINGHAM,DEPT OPHTHALMOL,NOTTINGHAM NG7 2RD,ENGLAND.
NEI,BETHESDA,MD 20892.
RI Rizzo, Luiz Vicente/B-4458-2009
NR 0
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S840
EP S840
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91503857
ER
PT J
AU GONZALEZFERNANDEZ, I
BAKER, EL
BAER, C
OKAJIMA, TIL
WIGGERT, B
PEPPERBERG, DR
AF GONZALEZFERNANDEZ, I
BAKER, EL
BAER, C
OKAJIMA, TIL
WIGGERT, B
PEPPERBERG, DR
TI RECOMBINANT IRBP 4TH REPEAT
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
ID RETINOID-BINDING PROTEIN; INTERPHOTORECEPTOR
C1 UNIV VIRGINIA,DEPT OPHTHALMOL,CHARLOTTESVILLE,VA 22903.
UNIV ILLINOIS,DEPT OPHTHALMOL & VISUAL SCI,URBANA,IL 61801.
NEI,BETHESDA,MD 20892.
NR 4
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S6
EP S6
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91500027
ER
PT J
AU GOPALSRIVASTAVA, R
HAYNES, J
PIATIGORSKY, J
AF GOPALSRIVASTAVA, R
HAYNES, J
PIATIGORSKY, J
TI REGULATION OF THE MURINE ALPHA-B-CRYSTALLIN GENE IN CARDIAC-MUSCLE
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S880
EP S880
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91504023
ER
PT J
AU GUEXCROSIER, Y
WITTWER, AJ
ROBERGE, FG
AF GUEXCROSIER, Y
WITTWER, AJ
ROBERGE, FG
TI CYTOKINE-INDUCED NEUTROPHIL CHEMOATTRACTANT (CINC) IN ENDOTOXIN-INDUCED
UVEITIS (EIU)
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
MONSANTO CO,CORP RES,ST LOUIS,MO 63166.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S385
EP S385
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91501808
ER
PT J
AU HAYNES, JI
MCDERMOTT, JB
PIATIGORSKY, J
AF HAYNES, JI
MCDERMOTT, JB
PIATIGORSKY, J
TI PROMOTER ANALYSIS OF THE CHICKEN BETA-A3/A1-CRYSTALLIN GENE
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,LMDB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S881
EP S881
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91504031
ER
PT J
AU HESS, HH
ANZANO, MA
AF HESS, HH
ANZANO, MA
TI POSTERIOR SUBCAPSULAR CATARACTS IN RATS TREATED WITH
N-METHYL-N-NITROSOUREA
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
NCI,BETHESDA,MD 20892.
NR 2
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S605
EP S605
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91502796
ER
PT J
AU HOOKS, JJ
KOMURASAKI, Y
DETRICK, B
AF HOOKS, JJ
KOMURASAKI, Y
DETRICK, B
TI EXPRESSION OF VIRAL-RNA, VIRAL-PROTEINS, AND MHC MOLECULES WITHIN RPE
AND CILIARY BODY EPITHELIUM DURING CORONAVIRUS INDUCED RETINOPATHY
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
GEORGE WASHINGTON UNIV,MED CTR,WASHINGTON,DC 20037.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S145
EP S145
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91500700
ER
PT J
AU HOPE, JN
CHAMBERS, C
RUSSELL, P
LEE, L
HEJTMANCIK, JF
AF HOPE, JN
CHAMBERS, C
RUSSELL, P
LEE, L
HEJTMANCIK, JF
TI FUNCTION OF N-TERMINAL EXTENSION IN BETA-B2-CRYSTALLIN OLIGOMERIZATION
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
NR 2
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S886
EP S886
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91504058
ER
PT J
AU ILAGAN, JG
CVEKL, A
KANTOROW, M
PIATIGORSKY, J
SAX, CM
AF ILAGAN, JG
CVEKL, A
KANTOROW, M
PIATIGORSKY, J
SAX, CM
TI MEMBERS OF THE AP1 FAMILY INTERACT WITH A DOWNSTREAM ELEMENT, PE2, IN
THE MOUSE ALPHA-A-CRYSTALLIN PROMOTER
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NIH RES SCHOLARS PROGRAM,HHMI,BETHEWSDA,MD.
NEI,MOLEC & DEV BIOL LAB,BETHESDA,MD 20892.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S882
EP S882
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91504033
ER
PT J
AU IWATA, F
WOZENCRAFT, LA
CARUSO, RC
LI, A
GAHL, WA
MCCAIN, LM
KAISERKUPFER, MI
AF IWATA, F
WOZENCRAFT, LA
CARUSO, RC
LI, A
GAHL, WA
MCCAIN, LM
KAISERKUPFER, MI
TI NEPHROPATHIC CYSTINOSIS - NATURAL-HISTORY OF OCULAR FINDINGS AND RESULTS
OF CLINICAL-TRIAL OF CYSTEAMINE EYE DROP INTERVENTION
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
NICHHD,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S1056
EP S1056
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91504860
ER
PT J
AU IWATA, T
CARPER, DA
AF IWATA, T
CARPER, DA
TI CHARACTERIZATION OF THE HUMAN SORBITOL DEHYDROGENASE GENE PROMOTER
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
NR 1
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S879
EP S879
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91504013
ER
PT J
AU JACOT, JL
GLOVER, JP
BANIK, R
FELDMAN, BL
ROBISON, WG
AF JACOT, JL
GLOVER, JP
BANIK, R
FELDMAN, BL
ROBISON, WG
TI NOVEL IMPROVEMENTS IN GOLD CHLORIDE PROCEDURES FOR OPTIMAL PRESERVATION
OF NERVE STAINING IN WHOLE MOUNTS OF RAT CORNEAS
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,PATHOPHYSIOL SECT,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S575
EP S575
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91502666
ER
PT J
AU JIAO, X
LEE, J
CHADER, GJ
AF JIAO, X
LEE, J
CHADER, GJ
TI CLONING AND CHARACTERIZATION OF THE RAT GENE ENCODING RETINAL
FATTY-ACID-BINDING PROTEIN (R-FABP)
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S621
EP S621
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91502855
ER
PT J
AU KADOR, PF
SECCHI, EF
LIZAK, MJ
SATO, S
AF KADOR, PF
SECCHI, EF
LIZAK, MJ
SATO, S
TI COMPARISON OF POLYOL PATHWAY FLUX IN LENS, RETINA AND NERVE
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,OCULAR THERAPEUT LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S886
EP S886
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91504057
ER
PT J
AU KIKUCHI, T
WAWROUSEK, E
LEE, R
DICAMILLO, S
KUSUZAKI, K
SHINOHARA, T
AF KIKUCHI, T
WAWROUSEK, E
LEE, R
DICAMILLO, S
KUSUZAKI, K
SHINOHARA, T
TI POSITION OR NUMBER OF PHOTORECEPTOR CONSERVED ELEMENT (PCE1) IN ARRESTIN
PROMOTER MAY BE ALTERED IN MOLECULAR EVOLUTION
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 BRIGHAM & WOMENS HOSP,CTR OPHTHALM RES,BOSTON,MA 02115.
NEI,LMDB,BETHESDA,MD 20892.
RI Wawrousek, Eric/A-4547-2008
NR 0
TC 3
Z9 3
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S772
EP S772
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91503556
ER
PT J
AU KOZHICH, AT
CASPI, RR
GERY, I
AF KOZHICH, AT
CASPI, RR
GERY, I
TI CONSTRUCTION OF SUPERIOR UVEITOGENIC EPITOPES AND THEIR PROPERTIES
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S858
EP S858
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91503921
ER
PT J
AU KUTTY, RK
KUTTY, G
HOOKS, JJ
CHADER, GJ
WIGGERT, B
NAGINENI, CN
AF KUTTY, RK
KUTTY, G
HOOKS, JJ
CHADER, GJ
WIGGERT, B
NAGINENI, CN
TI INCREASED EXPRESSION OF THE INDUCIBLE FORM OF NITRIC-OXIDE SYNTHASE
MESSENGER-RNA IN HUMAN RETINAL-PIGMENT EPITHELIAL (RPE) CELLS BY
CYTOKINES AND ITS INHIBITION BY TRANSFORMING GROWTH-FACTOR-BETA
(TGF-BETA)
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S204
EP S204
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91500938
ER
PT J
AU LACKNER, PA
SATO, S
LIZAK, MJ
WYMAN, M
KADOR, PF
AF LACKNER, PA
SATO, S
LIZAK, MJ
WYMAN, M
KADOR, PF
TI AGE-DEPENDENT LENS CHANGES IN GALACTOSE-FED DOGS
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,OCULAR THERAPEUT LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S799
EP S799
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91503692
ER
PT J
AU LAI, JC
WAWROUSEK, EF
FUKUSHIMA, A
LOBANOFF, MC
LEE, RS
WHITCUP, SM
SMITHGILL, S
GERY, I
AF LAI, JC
WAWROUSEK, EF
FUKUSHIMA, A
LOBANOFF, MC
LEE, RS
WHITCUP, SM
SMITHGILL, S
GERY, I
TI IMMUNOTOLERANCE IN TRANSGENIC (TG) MICE EXPRESSING A FOREIGN ANTIGEN IN
THEIR LENS
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
NCI,BETHESDA,MD 20892.
NIH,HOWARD HUGHES MED INST,RES SCHOLARS PROBGRAM,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S201
EP S201
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91500928
ER
PT J
AU LAVER, NM
JACOT, JL
GLOVER, JP
LAZAROUS, DF
UNGER, EF
SHAH, SM
ROBISON, WG
AF LAVER, NM
JACOT, JL
GLOVER, JP
LAZAROUS, DF
UNGER, EF
SHAH, SM
ROBISON, WG
TI ABSENCE OF RETINAL NEOVASCULARIZATION FOLLOWING CHRONIC, SYSTEMIC BASIC
FIBROBLAST GROWTH-FACTOR ADMINISTRATION
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 GEORGETOWN UNIV,SCH MED,WASHINGTON,DC 20057.
NEI,BETHESDA,MD 20892.
NHLBI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S402
EP S402
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91501865
ER
PT J
AU LEE, J
JIAO, X
CHADER, GJ
AF LEE, J
JIAO, X
CHADER, GJ
TI CULTURED MONKEY PIGMENT EPITHELIAL (PE) CELLS CONTAIN A
FATTY-ACID-BINDING PROTEIN (FABP) THAT BINDS DOCOSAHEXAENOIC ACID (DHA)
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S138
EP S138
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91500670
ER
PT J
AU LI, X
MA, W
BARKER, JL
PIATIGORSKY, J
AF LI, X
MA, W
BARKER, JL
PIATIGORSKY, J
TI TRANSIENT EXPRESSION OF GLUTAMATE-DECARBOXYLASE (GAD67) IN THE
DEVELOPING RAT LENS
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,MOLEC & DEV BIOL LAB,BETHESDA,MD 20892.
NINCDS,NEUROPHYSIOL LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S176
EP S176
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91500841
ER
PT J
AU LIZAK, MJ
MORI, K
CECKLER, TL
BALABAN, RS
KADOR, PF
AF LIZAK, MJ
MORI, K
CECKLER, TL
BALABAN, RS
KADOR, PF
TI QUANTITATION OF OSMOTIC CATARACTS IN GALACTOSE-FED BEAGLES USING
MAGNETIZATION-TRANSFER CONTRAST-ENHANCED MAGNETIC-RESONANCE-IMAGING
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,OCULAR THERAPEUT LAB,BETHESDA,MD 20892.
NHLBI,CARDIAC ENERGET LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S801
EP S801
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91503700
ER
PT J
AU LOBANOFF, MC
LAI, JC
WAWROUSEK, EF
FUKUSHIMA, A
LEE, RS
CHAN, CC
WHITCUP, SM
GERY, I
AF LOBANOFF, MC
LAI, JC
WAWROUSEK, EF
FUKUSHIMA, A
LEE, RS
CHAN, CC
WHITCUP, SM
GERY, I
TI CELL-MEDIATED, LENS-INDUCED UVEITIS IN TRANSGENIC (TG) MICE - A NOVEL
EXPERIMENTAL EYE DISEASE
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
NIH,HOWARD HUGHES MED INST,RES SCHOLARS PROGRAM,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S202
EP S202
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91500931
ER
PT J
AU LU, SC
NAGINENI, CN
HOOKS, JJ
KANNAN, R
AF LU, SC
NAGINENI, CN
HOOKS, JJ
KANNAN, R
TI BIDIRECTIONAL TRANSPORT OF INTACT GLUTATHIONE (GSH) BY CULTURED HUMAN
RETINAL PIGMENTED EPITHELIAL-CELLS (HRPE)
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 USC,SCH MED,DIV GASSTROINTESTINAL & LIVER DIS,LOS ANGELES,CA.
NEI,BETHESDA,MD 20892.
NR 2
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S520
EP S520
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91502402
ER
PT J
AU LUYO, DA
LI, Q
PENG, B
CHAN, CC
AF LUYO, DA
LI, Q
PENG, B
CHAN, CC
TI TOPICAL CYCLOSPORINE INHIBITS MAST-CELL MEDIATED CONJUNCTIVITIS
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S839
EP S839
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91503853
ER
PT J
AU MAGNO, BV
DATILES, MB
LASA, MSM
AF MAGNO, BV
DATILES, MB
LASA, MSM
TI EVALUATION OF VISUAL FUNCTION FOLLOWING ND-YAG LASER POSTERIOR
CAPSULOTOMY
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,OPHTHALM GENET & CLIN SERV BRANCH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S812
EP S812
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91503761
ER
PT J
AU MAHDI, RM
SMITH, JA
NUSSENBLATT, RB
EGWUAGU, CE
AF MAHDI, RM
SMITH, JA
NUSSENBLATT, RB
EGWUAGU, CE
TI CHARACTERIZATION OF RETINAL GAMMA/DELTA+ T-CELL REPERTOIRE DURING
EXPERIMENTAL AUTOIMMUNE UVEORETINITIS (EAU)
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S859
EP S859
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91503926
ER
PT J
AU MAHURKAR, AA
TRUS, BL
VIVINO, MA
KUEHL, EM
DATILES, MB
KAISERKUPFER, MI
AF MAHURKAR, AA
TRUS, BL
VIVINO, MA
KUEHL, EM
DATILES, MB
KAISERKUPFER, MI
TI RETINAL FUNDUS PHOTO MONTAGES - A NEW COMPUTER-BASED METHOD
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,OPHTHALM GENET & CLIN SERV BRANCH,BETHESDA,MD 20892.
NIH,DIV COMP RES & TECHNOL,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S247
EP S247
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91501117
ER
PT J
AU MARTIN, DF
PARKS, DJ
MELLOW, SD
FERRIS, FL
WALTON, RC
REMALEY, NA
CHEW, EY
ASHTON, P
DAVIS, MD
NUSSENBLATT, RB
AF MARTIN, DF
PARKS, DJ
MELLOW, SD
FERRIS, FL
WALTON, RC
REMALEY, NA
CHEW, EY
ASHTON, P
DAVIS, MD
NUSSENBLATT, RB
TI TREATMENT OF CYTOMEGALOVIRUS RETINITIS WITH AN INTRAOCULAR
SUSTAINED-RELEASE GANCICLOVIR IMPLANT - A RANDOMIZED CONTROLLED
CLINICAL-TRIAL
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEW ENGLAND EYE CTR,BOSTON,MA.
NEI,BETHESDA,MD 20892.
EMORY UNIV,ATLANTA,GA 30322.
UNIV WISCONSIN,MADISON,WI 53706.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S820
EP S820
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91503788
ER
PT J
AU MILLERRIVERO, NE
RIZZO, LV
STIFF, LR
CHAN, CC
WIGGERT, B
NUSSENBLATT, RB
CASPI, RR
AF MILLERRIVERO, NE
RIZZO, LV
STIFF, LR
CHAN, CC
WIGGERT, B
NUSSENBLATT, RB
CASPI, RR
TI SUPPRESSION OF IRBP-INDUCED EU IN MICE DEFICIENT IN IL-4 AND IL-10
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 MARYLAND GEN HOSP,BALTIMORE,MD.
NEI,BETHESDA,MD 20892.
RI Rizzo, Luiz Vicente/B-4458-2009
NR 0
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S201
EP S201
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91500930
ER
PT J
AU MURPHY, CJ
RUSSELL, P
REID, TW
AF MURPHY, CJ
RUSSELL, P
REID, TW
TI SUBSTANCE-P ACCELERATES CORNEAL EPITHELIAL WOUND-HEALING OF GALACTOSEMIC
RATS
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 UNIV WISCONSIN,SCH VET MED,DEPT SURG SCI,MADISON,WI 53706.
TEXAS TECH UNIV,LUBBOCK,TX 79409.
NEI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S572
EP S572
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91502652
ER
PT J
AU NAGINENI, C
MARTINS, MC
DETRICK, B
HOOKS, JJ
AF NAGINENI, C
MARTINS, MC
DETRICK, B
HOOKS, JJ
TI INTERFERON-GAMMA INHIBITS TOXOPLASMA-GONDII REPLICATION IN HUMAN RPE
CELLS BY NITRIC-OXIDE - INDEPENDENT MECHANISMS
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
GEORGE WASHINGTON UNIV,MED CTR,WASHINGTON,DC 20037.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S787
EP S787
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91503630
ER
PT J
AU NEUENSCHWANDER, H
TAKAHASHI, Y
KADOR, PF
AF NEUENSCHWANDER, H
TAKAHASHI, Y
KADOR, PF
TI QUANTIFICATION OF RETINAL VESSEL CHANGES ASSOCIATED WITH
DIABETIC-RETINOPATHY IN GALACTOSE-FED DOGS
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,OCULAR THERAPEUT LAB,BETHESDA,MD 20892.
NR 2
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S485
EP S485
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91502239
ER
PT J
AU NUSSENBLATT, RB
WHITCUP, SM
DESMET, MD
CASPI, RR
RIZZO, LV
WEINER, H
GERY, I
AF NUSSENBLATT, RB
WHITCUP, SM
DESMET, MD
CASPI, RR
RIZZO, LV
WEINER, H
GERY, I
TI THE USE OF ORAL TOLERANCE IN THE MANIPULATION OF THE IMMUNE-RESPONSE
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,IMMUNOL LAB,BETHESDA,MD 20892.
HARVARD UNIV,BRIGHAM & WOMENS HOSP,BOSTON,MA 02115.
RI Rizzo, Luiz Vicente/B-4458-2009
NR 0
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S11
EP S11
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91500043
ER
PT J
AU PALMON, FE
JOPLIN, AC
DVORAK, JA
OBRITCH, WF
CHAN, C
MOYES, AL
HOLLAND, EJ
AF PALMON, FE
JOPLIN, AC
DVORAK, JA
OBRITCH, WF
CHAN, C
MOYES, AL
HOLLAND, EJ
TI HUMAN EPITHELIAL-CELL VIABILITY FOLLOWING KERATOEPITHELIOPLASTY IN A
RABBIT MODEL
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 UNIV MINNESOTA,DEPT OPHTHALMOL,MINNEAPOLIS,MN 55455.
EYE CTR FLORIDA,FT MYERS,FL.
NEI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S696
EP S696
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91503190
ER
PT J
AU PENG, B
LI, Q
ROBERGE, FG
NUSSENBLATT, RB
CHAN, CC
AF PENG, B
LI, Q
ROBERGE, FG
NUSSENBLATT, RB
CHAN, CC
TI THE ROLE OF TRANSFORMING GROWTH-FACTOR-BETA-1 (TGF-BETA-1) IN
ENDOTOXIN-INDUCED UVEITIS (EIU)
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S545
EP S545
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91502527
ER
PT J
AU PEREZ, J
HAMASAKI, DI
REDMOND, M
SHINOHARA, T
AF PEREZ, J
HAMASAKI, DI
REDMOND, M
SHINOHARA, T
TI MORPHOLOGICAL-CHANGES INDUCED BY INOCULATION OF AN ESCHERICHIA-COLI
EXPRESSING A 65 KD RPE PROTEIN
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
B&WH,CTR OPHTHALMOL,BOSTON,TX.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S763
EP S763
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91503518
ER
PT J
AU PRENDERGAST, RA
COSKUNCAN, NM
LUTTY, GA
MCLEOD, DS
CASPI, RR
AF PRENDERGAST, RA
COSKUNCAN, NM
LUTTY, GA
MCLEOD, DS
CASPI, RR
TI ANTERIOR SEGMENT AND RETINAL INVOLVEMENT IN EAU DEPENDS UPON MATURATION
OF ANTIGEN-PRESENTING CELLS (APC)
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 JHU,APPL PHYS LAB,LAUREL,MD.
NEI,BETHESDA,MD 20892.
JOHNS HOPKINS UNIV HOSP,WILMER OPHTHALMOL INST,BALTIMORE,MD 21205.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S859
EP S859
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91503927
ER
PT J
AU QIN, C
ROBISON, WG
ZIGLER, JS
AF QIN, C
ROBISON, WG
ZIGLER, JS
TI HISTOLOGICAL ANALYSIS OF CATARACT DEVELOPMENT IN GUINEA-PIGS WITH
MUTATION OF THE ZETA-CRYSTALLIN GENE
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S799
EP S799
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91503691
ER
PT J
AU RAO, PV
TABOR, Y
ZIGLER, JS
GARLAND, D
AF RAO, PV
TABOR, Y
ZIGLER, JS
GARLAND, D
TI 2-D ANALYSIS OF BLUE SEPHAROSE BOUND PROTEINS FROM THE LENS OF DIFFERENT
SPECIES
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,MECHANISMS OCULAR DIS LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S883
EP S883
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91504042
ER
PT J
AU REDMOND, TM
HARRIS, EW
YU, S
LIU, SY
KAPSIS, A
HAMEL, CP
AF REDMOND, TM
HARRIS, EW
YU, S
LIU, SY
KAPSIS, A
HAMEL, CP
TI ANALYSIS OF THE HUMAN GENE FOR THE RETINAL-PIGMENT EPITHELIUM-SPECIFIC
PROTEIN RPE65
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
INSERM,U254,F-34100 MONTPELLIER,FRANCE.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S598
EP S598
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91502770
ER
PT J
AU REMALEY, N
CHEW, E
SUGIMOTO, T
PODGOR, M
BATEMAN, B
KLEBANOFF, M
AF REMALEY, N
CHEW, E
SUGIMOTO, T
PODGOR, M
BATEMAN, B
KLEBANOFF, M
TI RISK-FACTORS FOR CONGENITAL CATARACTS
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NIH,BETHESDA,MD 20892.
UNIV CALIF LOS ANGELES,LOS ANGELES,CA 90024.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S806
EP S806
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91503730
ER
PT J
AU RENGARAJAN, K
DESMET, MD
KEDAR, I
KOZHICH, AT
CHADER, GJ
WIGGERT, B
AF RENGARAJAN, K
DESMET, MD
KEDAR, I
KOZHICH, AT
CHADER, GJ
WIGGERT, B
TI BINDING OF HEAT-SHOCK 70 PROTEINS FROM HUMAN AND RAB B-CELLS TO IRBP
PEPTIDES AND PATHOGENICITY OF PEPTIDES IN THE LEWIS RAT
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
NR 2
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S123
EP S123
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91500601
ER
PT J
AU REUTER, LM
CARUSO, RC
LOPEZ, P
KAISERKUPFER, MI
AF REUTER, LM
CARUSO, RC
LOPEZ, P
KAISERKUPFER, MI
TI EFFECT OF PUPIL SIZE ON THE GANZFELD ELECTRORETINOGRAM
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,OPHTHALM GENET & CLIN SERV BRANCH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S924
EP S924
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91504238
ER
PT J
AU ROBISON, WG
LAVER, NM
JACOT, JL
HOHMAN, TC
AF ROBISON, WG
LAVER, NM
JACOT, JL
HOHMAN, TC
TI PREVENTION OF CATARACTS AND AMELIORATION OF DIABETIC-LIKE RETINOPATHY
WITH THE ALDOSE REDUCTASE INHIBITOR WAY-121,509
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
GEORGETOWN UNIV,SCH MED,WASHINGTON,DC 20007.
WYETH AYERST LABS RES INC,PRINCETON,NJ.
NR 0
TC 1
Z9 1
U1 0
U2 1
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S173
EP S173
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91500829
ER
PT J
AU RUSSELL, P
JOHNSON, DH
AF RUSSELL, P
JOHNSON, DH
TI 2-DIMENSIONAL GEL-ELECTROPHORESIS OF SEGMENTS OF HUMAN TRABECULAR
MESHWORK
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
MAYO CLIN & MAYO FDN,ROCHESTER,MN 55905.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S129
EP S129
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91500624
ER
PT J
AU SARTANI, G
SILVER, PB
VELEZ, G
CHAN, CC
WIGGERT, B
MASTORAKOS, G
CASPI, RR
AF SARTANI, G
SILVER, PB
VELEZ, G
CHAN, CC
WIGGERT, B
MASTORAKOS, G
CASPI, RR
TI ANTI-TNF THERAPY CAN SUPPRESS THE INDUCTION OF EAU IN MICE
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NICHHD,BETHESDA,MD.
NEI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S859
EP S859
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91503924
ER
PT J
AU SATO, S
SECCHI, EF
FUKASE, S
LIZAK, MJ
KADOR, PF
AF SATO, S
SECCHI, EF
FUKASE, S
LIZAK, MJ
KADOR, PF
TI POLYOL PATHWAY IN CULTURED DOG PERICYTES
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,OCULAR THERAPEUT LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S1067
EP S1067
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91504899
ER
PT J
AU SECCHI, EF
LIZAK, MJ
SATO, S
KADOR, PF
AF SECCHI, EF
LIZAK, MJ
SATO, S
KADOR, PF
TI POLYOL PATHWAY FLUX MEASUREMENTS IN DOG LENS BY F-19-NMR
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,OCULAR THERAPEUT LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S886
EP S886
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91504056
ER
PT J
AU SHASTRY, BS
HEJTMANCIK, JF
PLAGER, DA
HARTZER, MK
TRESE, MT
AF SHASTRY, BS
HEJTMANCIK, JF
PLAGER, DA
HARTZER, MK
TRESE, MT
TI X-LINKED FAMILIAL EXUDATIVE VITREORETINOPATHY (FEVR) - LINKAGE ANALYSIS
AND MUTATION WITHIN A CANDIDATE GENE
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 OAKLAND UNIV,EYE RES INST,ROCHESTER,MI 48063.
NEI,BETHESDA,MD 20892.
INDIANA UNIV,BLOOMINGTON,IN 47401.
WILLIAM BEAUMONT HOSP,ROYAL OAK,MI 48072.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S893
EP S893
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91504094
ER
PT J
AU SI, Q
PENG, B
LUYO, D
CHAN, CC
AF SI, Q
PENG, B
LUYO, D
CHAN, CC
TI EXPRESSION OF PHOSPHOLIPASE A2S (PLA2S) IN MURINE ALLERGIC
CONJUNCTIVITIS - KINETICS AND MODULATION
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,IMMUNOL LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S1025
EP S1025
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91504738
ER
PT J
AU SILVER, PB
RIZZO, LV
SARTANI, G
CHAN, CC
WIGGERT, B
NUSSENBLATT, RB
CASPI, RR
AF SILVER, PB
RIZZO, LV
SARTANI, G
CHAN, CC
WIGGERT, B
NUSSENBLATT, RB
CASPI, RR
TI HETEROLOGOUS EPITOPES OF IRBP PROTECT AGAINST AUTOIMMUNE UVEITIS INDUCED
BY THE AUTOLOGOUS EPITOPE
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
RI Rizzo, Luiz Vicente/B-4458-2009
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S858
EP S858
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91503922
ER
PT J
AU SMITH, JA
WHITCUP, S
MAHDI, RM
NUSSENBLATT, RB
EGWUAGU, CE
AF SMITH, JA
WHITCUP, S
MAHDI, RM
NUSSENBLATT, RB
EGWUAGU, CE
TI T-CELL RECEPTOR-GAMMA/DELTA USAGE IN HUMAN OCULAR SARCOIDOSIS
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S537
EP S537
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91502497
ER
PT J
AU SMITH, SB
WONG, P
BORA, N
KUTTY, G
MCCOOL, D
KUTTY, K
CHADER, G
WIGGERT, B
AF SMITH, SB
WONG, P
BORA, N
KUTTY, G
MCCOOL, D
KUTTY, K
CHADER, G
WIGGERT, B
TI PHOTORECEPTOR CELLS DIE BY APOPTOSIS IN THE VITILIGO M(VIT)/MI(VIT)
MOUSE
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 MED COLL GEORGIA,DEPT CELL BIOL & ANAT,AUGUSTA,GA 30912.
MED COLL GEORGIA,DEPT OPHTHALMOL,AUGUSTA,GA 30912.
NEI,LRCMB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S638
EP S638
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91502912
ER
PT J
AU STIFF, LR
RIZZO, LV
CHOI, R
CASPI, RR
AF STIFF, LR
RIZZO, LV
CHOI, R
CASPI, RR
TI THE ROLE OF TH1 AND TH2 TYPE CYTOKINES IN THE DEVELOPMENT AND TREATMENT
OF EAU
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 HOWARD HUGHES MED INST NIH,RES SCHOLARS PROGRAM,BETHESDA,MD.
NEI,BETHESDA,MD 20892.
RI Rizzo, Luiz Vicente/B-4458-2009
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S859
EP S859
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91503925
ER
PT J
AU SULLIVAN, D
ANGLADE, E
SALAMON, C
HOOKS, J
NUSSENBLATT, R
CSAKY, K
AF SULLIVAN, D
ANGLADE, E
SALAMON, C
HOOKS, J
NUSSENBLATT, R
CSAKY, K
TI ADENOVIRUS-MEDIATED GENE-TRANSFER OF TRANSFORMING GROWTH-FACTOR-BETA-1
AND ORNITHINE AMINOTRANSFERASE IN CULTURED HUMAN BPE
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,IMMUNOL LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S98
EP S98
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91500473
ER
PT J
AU SUN, B
SILVER, PB
WELLS, J
WILDER, RL
CASPI, RR
AF SUN, B
SILVER, PB
WELLS, J
WILDER, RL
CASPI, RR
TI ANALYSIS OF CYTOKINES PRODUCED BY SUSCEPTIBLE AND RESISTANT RATS
IMMUNIZED WITH A PATHOGENIC PEPTIDE
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NIAMS,BETHESDA,MD.
NEI,IMMUNOL LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S858
EP S858
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91503923
ER
PT J
AU SUZUKI, S
LI, Q
PENG, B
WIGGERT, BN
KOHN, LD
NUSSENBLATT, RB
CHAN, CC
AF SUZUKI, S
LI, Q
PENG, B
WIGGERT, BN
KOHN, LD
NUSSENBLATT, RB
CHAN, CC
TI METHIMAZOLE (MMI), AN AGENT CAPABLE OF REDUCING MHC CLASS-I EXPRESSION,
INHIBITS EXPERIMENTAL MELANIN-INDUCED UVEITIS (EMIU) AND EXPERIMENTAL
AUTOIMMUNE UVEORETINITIS (EAU)
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
NIDDKD,BETHESDA,MD.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S542
EP S542
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91502512
ER
PT J
AU TILLER, GE
HEINZMANN, C
KOJIS, TL
GONZALEZ, P
BATEMAN, JB
AF TILLER, GE
HEINZMANN, C
KOJIS, TL
GONZALEZ, P
BATEMAN, JB
TI LINKAGE MAPPING OF ZETA-CRYSTALLIN ON HUMAN CHROMOSOME-1P - APPLICATION
TO HEREDITARY CATARACTS
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 UNIV CALIF LOS ANGELES, JULES STEIN EYE INST, LOS ANGELES, CA USA.
VANDERBILT UNIV, MED CTR, NASHVILLE, TN 37240 USA.
NIH, BETHESDA, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC
PI ROCKVILLE
PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S879
EP S879
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91504018
ER
PT J
AU TOHAH, H
LE, D
CHAN, CC
NUSSENBLATT, RB
AF TOHAH, H
LE, D
CHAN, CC
NUSSENBLATT, RB
TI THE IN-VITRO EFFECTS OF CYCLOSPORINE-A (CSA) ON CORNEA
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 UNIV ULSAN,DEPT OPHTHALMOL,SEOUL,SOUTH KOREA.
NEI,IMMUNOL LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S300
EP S300
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91501389
ER
PT J
AU TOMAREV, SI
ZINOVIEVA, RD
DUNCAN, MK
BANERJEEBASU, S
JOHNSON, T
SUNDIN, O
YANG, JM
PIATIGORSKY, J
AF TOMAREV, SI
ZINOVIEVA, RD
DUNCAN, MK
BANERJEEBASU, S
JOHNSON, T
SUNDIN, O
YANG, JM
PIATIGORSKY, J
TI HOMEOBOX GENE PROX-1 AND LENS DEVELOPMENT
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 JOHNS HOPKINS UNIV,SCH MED,WILMER EYE INST,BALTIMORE,MD 21205.
NEI,MOLEC & DEV BIOL LAB,BETHESDA,MD 20892.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S844
EP S844
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91503871
ER
PT J
AU TOYAMA, ES
OKAMOTO, S
MAKONNEN, S
SUNDARRAJ, N
HASSELL, JR
SATO, S
KADOR, PF
AF TOYAMA, ES
OKAMOTO, S
MAKONNEN, S
SUNDARRAJ, N
HASSELL, JR
SATO, S
KADOR, PF
TI DEVELOPMENT OF AN IN-VITRO MODEL OF GALACTOSE-INDUCED
KERATOEPITHELIOPATHY USING A CORNEAL EPITHELIAL-CELL LINE
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 UNIV PITTSBURGH,DEPT OPHTHALMOL,PITTSBURGH,PA 15260.
NEI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S701
EP S701
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91503218
ER
PT J
AU TUMMINIA, SJ
RUSSELL, P
AF TUMMINIA, SJ
RUSSELL, P
TI CATARACT FORMATION IN TRANSGENIC MICE CONTAINING HIV-1 PROTEASE LINKED
TO THE ALPHA-A-CRYSTALLIN PROMOTER
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,MECHANISMS OCULAR DIS LAB,BETHESDA,MD 20892.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S879
EP S879
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91504015
ER
PT J
AU VISTICA, BP
CHANAUD, NP
FELIX, N
RIZZO, LV
SILVER, PB
CASPI, RR
NUSSENBLATT, RB
GERY, T
AF VISTICA, BP
CHANAUD, NP
FELIX, N
RIZZO, LV
SILVER, PB
CASPI, RR
NUSSENBLATT, RB
GERY, T
TI CD8 T-CELLS ARE NOT ESSENTIAL FOR THE INDUCTION OF ORAL TOLERANCE
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
AUTOIMMUNE INC,LEXINGTON,MA.
RI Rizzo, Luiz Vicente/B-4458-2009
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S543
EP S543
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91502518
ER
PT J
AU WALTON, RC
LUYO, DA
NUSSENBLATT, RB
CHAN, CC
AF WALTON, RC
LUYO, DA
NUSSENBLATT, RB
CHAN, CC
TI INTERLEUKIN-10 EXPRESSION IN PATIENTS WITH UVEITIS
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S537
EP S537
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91502492
ER
PT J
AU WANG, X
OHTAKAMARUYAMA, C
CHEPELINSKY, AB
AF WANG, X
OHTAKAMARUYAMA, C
CHEPELINSKY, AB
TI TRANSCRIPTIONAL REGULATION OF THE HUMAN MIP GENE
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,MOLEC & DEV BIOL LAB,BETHESDA,MD 20892.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S882
EP S882
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91504034
ER
PT J
AU WANG, Y
COHEN, JI
PERERA, L
STRAUS, S
NUSSENBLATT, R
HOOKS, JJ
AF WANG, Y
COHEN, JI
PERERA, L
STRAUS, S
NUSSENBLATT, R
HOOKS, JJ
TI EXPERIMENTAL CHRONIC UVEITIS IN GUINEA-PIGS INFECTED WITH HUMAN
VARICELLA-ZOSTER VIRUS (VZV)
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
NIAID,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S150
EP S150
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91500729
ER
PT J
AU WAWROUSEK, EF
BRADY, JP
AF WAWROUSEK, EF
BRADY, JP
TI IN-VIVO INVESTIGATION OF CRYSTALLIN FUNCTION USING ALPHA-CRYSTALLIN GENE
KNOCKOUT MICE
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S882
EP S882
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91504035
ER
PT J
AU WHITCUP, SM
LOBANOFF, M
GERY, I
ISHIMOTO, S
WOLITSKY, B
NUSSENBLATT, RB
CHAN, CC
AF WHITCUP, SM
LOBANOFF, M
GERY, I
ISHIMOTO, S
WOLITSKY, B
NUSSENBLATT, RB
CHAN, CC
TI ROLE OF SELECTINS AND INTEGRINS IN THE PATHOGENESIS OF ENDOTOXIN-INDUCED
UVEITIS (EIU)
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
HOFFMANN LA ROCHE INC,NUTLEY,NJ 07110.
NR 0
TC 3
Z9 3
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S385
EP S385
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91501805
ER
PT J
AU WONG, P
ULYANOVA, T
DARROW, R
SHIVARAM, S
VANVEEN, T
CHADER, G
ORGANISCIAK, D
AF WONG, P
ULYANOVA, T
DARROW, R
SHIVARAM, S
VANVEEN, T
CHADER, G
ORGANISCIAK, D
TI CORRELATION OF LIGHT-INDUCED RETINAL DAMAGE IN RATS WITH CHANGES IN
TRPM-2/CLUSTERIN (TRPM-2) EXPRESSION
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
GOTHENBURG UNIV,DEPT ZOOL,S-41124 GOTHENBURG,SWEDEN.
WRIGHT STATE UNIV,DEPT BIOCHEM & MOLEC BIOL,DAYTON,OH 45435.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S860
EP S860
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91503931
ER
PT J
AU WU, YQ
BECERRA, SP
AF WU, YQ
BECERRA, SP
TI PEDF PROCESSING IN IPM AND VITREOUS
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,RETINAL CELL & MOLEC BIOL LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S131
EP S131
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91500635
ER
PT J
AU XU, H
REDMOND, M
WAWROUSEK, EF
NICKERSON, JM
CASPI, RR
AF XU, H
REDMOND, M
WAWROUSEK, EF
NICKERSON, JM
CASPI, RR
TI STUDIES OF TOLERANCE DEVELOPMENT TO RETINAL ANTIGENS USING TRANSGENIC
TECHNOLOGY .1. CONSTRUCTION OF THE GENES OF INTEREST
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
EMORY UNIV,DEPT OPHTHALMOL,ATLANTA,GA 30322.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S540
EP S540
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91502504
ER
PT J
AU YU, S
LIU, SY
DETRICK, B
HOOKS, JJ
REDMOND, TM
AF YU, S
LIU, SY
DETRICK, B
HOOKS, JJ
REDMOND, TM
TI OVER-EXPRESSION AND PURIFICATION OF RPE65 PROTEIN
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
GEORGE WASHINGTON UNIV,WASHINGTON,DC 20052.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S763
EP S763
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91503519
ER
PT J
AU ZADUNAISKY, JA
SPRING, KR
AF ZADUNAISKY, JA
SPRING, KR
TI TBM CELLS AREA CHANGES INDUCED BY DRUGS - IS IT CONTRACTION OR
CELL-VOLUME REGULATION
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NYU MED CTR,NEW YORK,NY 10016.
NIH,BETHESDA,MD 20892.
NR 0
TC 6
Z9 6
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S194
EP S194
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91500905
ER
PT J
AU ZELENKA, PS
ARORA, JK
LYSZ, TW
AF ZELENKA, PS
ARORA, JK
LYSZ, TW
TI A ROLE FOR 12(S)HETE IN THE RESPONSE OF HUMAN LENS EPITHELIAL-CELLS TO
EGF AND INSULIN
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
UNIV MED & DENT NEW JERSEY,NEW JERSEY MED SCH,NEWARK,NJ 07103.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT-RAVEN PUBL
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106
SN 0146-0404
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD MAR 15
PY 1995
VL 36
IS 4
BP S176
EP S176
PG 1
WC Ophthalmology
SC Ophthalmology
GA QM915
UT WOS:A1995QM91500842
ER
PT J
AU ANDERSON, EL
DECKER, MD
ENGLUND, JA
EDWARDS, KM
ANDERSON, P
MCINNES, P
BELSHE, RB
AF ANDERSON, EL
DECKER, MD
ENGLUND, JA
EDWARDS, KM
ANDERSON, P
MCINNES, P
BELSHE, RB
TI INTERCHANGEABILITY OF CONJUGATED HAEMOPHILUS-INFLUENZAE TYPE-B VACCINES
IN INFANTS
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Article
ID OUTER-MEMBRANE PROTEIN; 6-MONTH-OLD INFANTS; POLYSACCHARIDE;
IMMUNOGENICITY; DISEASE; 2-MONTH-OLD; CHILDREN; TRIAL
AB Objective.-To evaluate the safety and immunogenicity of two Haemophilus influenzae type b (Hib) conjugate vaccines when administered in serial combination, These vaccines consisted of Hib capsular polysaccharide polyribosyl-ribitol phosphate (PRP) conjugated to the meningococcal outer membrane protein (OMP) complex (PRP-OMP) and H influenzae oligosaccharide conjugated to a mutant toxin (CRM197) isolated from Corynebacterium diphtheriae (HbOC).
Design.-Randomized, double-blind, clinical trial evaluating five Hib vaccination regimens.
Setting.-Vaccine Treatment and Evaluation Units and affiliated private pediatric practices at Saint Louis (Mo) University, Vanderbilt University, Nashville, Tenn, and Baylor College of Medicine, Houston, Tex.
Patients.-A total of 497 healthy 2-month-old infants scheduled to receive routine immunization.
Intervention.-Participants received either PRP-OMP or HbOC given as recommended by the manufacturer, PRP-OMP at 2 and 6 months, HbOC at 2 months, then PRP-OMP at 4 and 6 months, or PRP-OMP at 2 months and then HbOC at 4 and 6 months. Unconjugated PRP was given at 15 months to evaluate priming.
Results.-Geometric mean antibody concentrations differed significantly among the groups following the second and third immunizations of the primary series and following booster immunization with unconjugated PRP. On each occasion, the groups receiving serial combinations of PRP-OMP and HbOC achieved mean antibody concentrations that equalled or exceeded those of the groups receiving a single product. Adverse reactions did not vary by group.
Conclusions.-The studied sequential combinations of Hib vaccines were safe and at least as immunogenic as either vaccine alone.
C1 ST LOUIS UNIV,SCH MED,DEPT PEDIAT,ST LOUIS,MO 63110.
VANDERBILT UNIV,SCH MED,DEPT PREVENT MED,NASHVILLE,TN 37212.
VANDERBILT UNIV,SCH MED,DEPT MED,NASHVILLE,TN 37212.
VANDERBILT UNIV,SCH MED,DEPT PEDIAT,NASHVILLE,TN 37212.
BAYLOR COLL MED,DEPT MICROBIOL & IMMUNOL,HOUSTON,TX 77030.
UNIV ROCHESTER,SCH MED & DENT,DEPT PEDIAT,ROCHESTER,NY 14642.
NIAID,DIV MICROBIOL & INFECT DIS,RESP DIS BRANCH,BETHESDA,MD 20892.
RP ANDERSON, EL (reprint author), ST LOUIS UNIV,HLTH SCI CTR,SCH MED,DEPT MED,DIV INFECT DIS,3635 VISTA AVE,FDT-8N,POB 15250,ST LOUIS,MO 63110, USA.
FU NIAID NIH HHS [N01-AI-02645, N01-AI-05051, N01-AI-72629]
NR 20
TC 27
Z9 29
U1 0
U2 2
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD MAR 15
PY 1995
VL 273
IS 11
BP 849
EP 853
DI 10.1001/jama.273.11.849
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA QL402
UT WOS:A1995QL40200021
PM 7869554
ER
PT J
AU CANNON, RO
AF CANNON, RO
TI THE SENSITIVE HEART - A SYNDROME OF ABNORMAL CARDIAC PAIN PERCEPTION
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Discussion
ID NORMAL CORONARY ARTERIOGRAMS; LEFT-VENTRICULAR HYPERTROPHY; ESOPHAGEAL
CHEST PAIN; SYNDROME-X; ANGINA-PECTORIS; FOLLOW-UP; FLOW RESERVE;
ENDOTHELIAL DYSFUNCTION; RESISTANCE VESSELS; ARTERY DISEASE
RP CANNON, RO (reprint author), NHLBI,CARDIOL BRANCH,BLDG 10,ROOM 7B-15,BETHESDA,MD 20892, USA.
NR 62
TC 39
Z9 41
U1 1
U2 1
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD MAR 15
PY 1995
VL 273
IS 11
BP 883
EP 887
DI 10.1001/jama.273.11.883
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA QL402
UT WOS:A1995QL40200028
PM 7869561
ER
PT J
AU PRATOLONGO, R
PERICO, A
FREED, KF
SZABO, A
AF PRATOLONGO, R
PERICO, A
FREED, KF
SZABO, A
TI MULTIEXPONENTIAL APPROXIMATIONS TO THE TORSIONAL TIME-CORRELATION
FUNCTION FOR ONE-DIMENSIONAL SYSTEMS WITH MANY BARRIERS
SO JOURNAL OF CHEMICAL PHYSICS
LA English
DT Article
ID CONFORMATIONAL TRANSITIONS; RELAXATION; DYNAMICS; POLYMERS;
MACROMOLECULES; DIFFUSION; KINETICS
C1 UNIV CHICAGO,JAMES FRANCK INST,CHICAGO,IL 60637.
UNIV CHICAGO,DEPT CHEM,CHICAGO,IL 60637.
NIDDKD,PHYS CHEM LAB,BETHESDA,MD 20892.
RP PRATOLONGO, R (reprint author), NATL RES COUNCIL,IST STUDI CHIMICOFIS MACROMOLEC SINTETICHE & NAT,GENOA,ITALY.
RI Szabo, Attila/H-3867-2012
NR 15
TC 7
Z9 7
U1 0
U2 1
PU AMER INST PHYSICS
PI WOODBURY
PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999
SN 0021-9606
J9 J CHEM PHYS
JI J. Chem. Phys.
PD MAR 15
PY 1995
VL 102
IS 11
BP 4683
EP 4690
DI 10.1063/1.469516
PG 8
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA QL735
UT WOS:A1995QL73500038
ER
PT J
AU ROMANOSPICA, V
GEORGIOU, P
SUZUKI, H
PAPAS, TS
BHAT, NK
AF ROMANOSPICA, V
GEORGIOU, P
SUZUKI, H
PAPAS, TS
BHAT, NK
TI ROLE OF ETS1 IN IL-2 GENE-EXPRESSION
SO JOURNAL OF IMMUNOLOGY
LA English
DT Article
ID LONG TERMINAL REPEAT; T-CELLS; INTERLEUKIN-2 GENE; ANTIGEN RECEPTOR;
DNA-BINDING; C-ETS; TRANSCRIPTION FACTORS; PROTO-ONCOGENE;
LYMPHOCYTES-T; ACTIVATION
AB The ETS1 gene encodes a sequence-specific transcription factor binding to purine-rich DNA sequences (-GGAA-) present in the transcriptional regulatory regions of many cellular and viral promoters/enhancers, including many lymphokine genes. The ETS1 gene is expressed at high levels in resting T cells and at very low levels after T cell activation, suggesting it may suppress the expression of genes induced during T cell activation. To find out if ETS1 regulates expression of the IL-2 gene, we have ectopically expressed antisense (AS) ETS1 in jurkat T cells to block the formation of ETS1 proteins. AS ETS1 transfectants produce higher levels of IL-2 compared with sense ETS1 transfectants. Expression of ETS1 DNA binding domain in Jurkat T cells also decreased the production of IL-2. In AS ETS1 transfectants, IL-2 formation was completely inhibited by cyclosporin A and FK590. The IL-2 promoter linked to a chloramphenicol acetyl transferase reporter gene has high activity in AS ETS1 transfectants, indicating that increased IL-2 production seems to be a result of transcriptional induction. Taken together, these results suggest the possibility that ETS1 may act as a negative regulator of IL-2 gene transcription and provide a rational approach toward engineering the endogenous expression of IL-2 in T cells.
C1 NCI,FREDERICK CANC RES & DEV CTR,PROGRAM RESOURCES INC DYNCORP,FREDERICK,MD 21702.
NCI,MOLEC ONCOL LAB,FREDERICK,MD 21702.
MED UNIV S CAROLINA,HOLLINGS CANC CTR,CTR MOLEC & STRUCT BIOL,CHARLESTON,SC 29425.
NR 48
TC 35
Z9 35
U1 1
U2 2
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814
SN 0022-1767
J9 J IMMUNOL
JI J. Immunol.
PD MAR 15
PY 1995
VL 154
IS 6
BP 2724
EP 2732
PG 9
WC Immunology
SC Immunology
GA QL084
UT WOS:A1995QL08400019
PM 7876544
ER
PT J
AU SHIRAI, M
ARICHI, T
NISHIOKA, M
NOMURA, T
IKEDA, K
KAWANISHI, K
ENGELHARD, VH
FEINSTONE, SM
BERZOFSKY, JA
AF SHIRAI, M
ARICHI, T
NISHIOKA, M
NOMURA, T
IKEDA, K
KAWANISHI, K
ENGELHARD, VH
FEINSTONE, SM
BERZOFSKY, JA
TI CTL RESPONSES OF HLA-A2.1-TRANSGENIC MICE SPECIFIC FOR HEPATITIS-C VIRAL
PEPTIDES PREDICT EPITOPES FOR CTL OF HUMANS CARRYING HLA-A2.1
SO JOURNAL OF IMMUNOLOGY
LA English
DT Article
ID NON-B-HEPATITIS; CYTOTOXIC LYMPHOCYTES-T; MAJOR HISTOCOMPATIBILITY
COMPLEX; NON-A; CELL RECOGNITION; TRANSGENIC MICE; ANTIGEN PRESENTATION;
MONOCLONAL-ANTIBODY; SYNTHETIC PEPTIDES; VIRUS-REPLICATION
AB Vaccine development in animal models depends on ability to recognize epitopes seen by human T cells. In this work, we show that CTL responses in transgenic mice expressing human HLA-A2.1 prospectively predict the same four of 11 hepatitis C virus (HCV) structural protein-derived peptides, expressing a sequence motif for HLA-A2.1 binding, that are actually recognized by human A2.1-restricted CTLs. The CTLs also recognized targets endogenously expressing these proteins. Human CTLs from HCV-infected patients, tested by using the same peptides, revealed a virtually identical response repertoire. A highly conserved HCV core peptide was the most immunogenic, and may be a valuable component of a vaccine against a broad range of HCV isolates in HLA-A2-positive patients. These results suggest that, in spite of species differences, the T cell repertoire is plastic enough to allow a similar response when the same class I MHC molecule is presenting the peptide. Thus, the HLA molecule plays the primary role in determining which peptides are recognized by CTLs. This transgenic mouse model is important for the study of HLA-restricted CTL determinants and for an approach to design a potential HCV vaccine.
C1 NCI,METAB BRANCH,MOLEC IMMUNOGENET & VACCINE RES SECT,BETHESDA,MD 20892.
KAGAWA MED SCH,DEPT INTERNAL MED 3,KAGAWA 76107,JAPAN.
KAGAWA MED SCH,DEPT TRANSFUS MED,KAGAWA 76107,JAPAN.
UNIV VIRGINIA,DEPT MICROBIOL,CHARLOTTESVILLE,VA 22908.
US FDA,CTR BIOL EVALUAT & RES,DIV VIROL,HEPATITIS RES LAB,BETHESDA,MD 20892.
RI Yang, Chen/G-1379-2010
FU NIAID NIH HHS [R01 AI21393]
NR 68
TC 151
Z9 154
U1 0
U2 1
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814
SN 0022-1767
J9 J IMMUNOL
JI J. Immunol.
PD MAR 15
PY 1995
VL 154
IS 6
BP 2733
EP 2742
PG 10
WC Immunology
SC Immunology
GA QL084
UT WOS:A1995QL08400020
PM 7533182
ER
PT J
AU KRUMHOLZ, HM
LARSON, M
LEVY, D
AF KRUMHOLZ, HM
LARSON, M
LEVY, D
TI PROGNOSIS OF LEFT-VENTRICULAR GEOMETRIC PATTERNS IN THE FRAMINGHAM
HEART-STUDY
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
ID ESSENTIAL-HYPERTENSION; SEX-DIFFERENCES; MASS; HYPERTROPHY
AB Objectives. The goal of this study was to determine the incremental mental prognostic value of left ventricular geometric patterns beyond that provided by cardiovascular disease risk factors, including left ventricular mass.
Background. Left ventricular geometry may be classified into the following four mutually exclusive groups on the basis of left ventricular mass and relative wall thickness: concentric hypertrophy (increased mass and increased relative wall thickness), eccentric hypertrophy (increased mass and normal relative wall thickness), concentric remodeling (normal mass and increased relative wall thickness) and normal geometry (normal mass and normal relative wall thickness). The prognosis associated with these patterns in a population-based sample is not known.
Methods. Proportional hazards regression models were used to evaluate the prognostic importance of left ventricular geometry in 3,216 subjects in the Framingham Heart Study who were greater than or equal to 40 years old and free of clinically apparent cardiovascular disease, after adjustment for traditional cardiovascular risk factors and left ventricular mass. The follow-up period was 8 years.
Results. Subjects with concentric hypertrophy had the worst prognosis, followed by those with eccentric hypertrophy, concentric remodeling and normal geometry. Subjects with concentric hypertrophy also had the highest left ventricular mass. The association between type of geometry and prognosis was largely attenuated by adjustment for baseline differences in left ventricular mass, The odds ratio for incident cardiovascular disease in subjects with concentric hypertrophy compared with those who had normal geometry was 13 (95% confidence interval [CI] 0.8 to 2.1) in men and 1.2 (95% CI 0.6 to 2.3) in women after adjustment for other cardiovascular risk factors, including left ventricular mass.
Conclusions. In a population-based sample of subjects without cardiovascular disease, knowledge of left ventricular geometry provided little prognostic information beyond that available from left ventricular mass and traditional cardiovascular risk factors.
C1 FRAMINGHAM HEART DIS EPIDEMIOL STUDY,FRAMINGHAM,MA 01701.
YALE UNIV,SCH MED,CARDIOVASC MED SECT,NEW HAVEN,CT.
NHLBI,BETHESDA,MD 20892.
BETH ISRAEL HOSP,DIV CARDIOVASC,BOSTON,MA 02215.
BETH ISRAEL HOSP,DIV CLIN EPIDEMIOL,BOSTON,MA 02215.
BOSTON UNIV,SCH MED,DIV EPIDEMIOL & PREVENT MED,BOSTON,MA 02118.
NR 25
TC 335
Z9 351
U1 0
U2 3
PU ELSEVIER SCIENCE PUBL CO INC
PI NEW YORK
PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010
SN 0735-1097
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD MAR 15
PY 1995
VL 25
IS 4
BP 879
EP 884
DI 10.1016/0735-1097(94)00473-4
PG 6
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA QL404
UT WOS:A1995QL40400011
PM 7884091
ER
PT J
AU BROWN, ML
FIREMAN, B
AF BROWN, ML
FIREMAN, B
TI EVALUATION OF DIRECT MEDICAL COSTS RELATED TO CANCER
SO JOURNAL OF THE NATIONAL CANCER INSTITUTE
LA English
DT Editorial Material
ID BREAST
RP BROWN, ML (reprint author), NCI,DIV CANC PREVENT & CONTROL,SURVEILLANCE PROGRAM,APPL RES BRANCH,EXECUT PLAZA N,RM 313,BETHESDA,MD 20892, USA.
NR 7
TC 10
Z9 10
U1 0
U2 0
PU NATL CANCER INSTITUTE
PI BETHESDA
PA 9030 OLD GEORGETOWN RD, BETHESDA, MD 20814
SN 0027-8874
J9 J NATL CANCER I
JI J. Natl. Cancer Inst.
PD MAR 15
PY 1995
VL 87
IS 6
BP 399
EP 400
DI 10.1093/jnci/87.6.399
PG 2
WC Oncology
SC Oncology
GA QL082
UT WOS:A1995QL08200001
PM 7861454
ER
PT J
AU HEINO, P
EKLUND, C
FREDERIKSSONSHANAZARIAN, V
GOLDMAN, S
SCHILLER, JT
DILLNER, J
AF HEINO, P
EKLUND, C
FREDERIKSSONSHANAZARIAN, V
GOLDMAN, S
SCHILLER, JT
DILLNER, J
TI ASSOCIATION OF SERUM IMMUNOGLOBULIN-G ANTIBODIES AGAINST HUMAN
PAPILLOMAVIRUS TYPE-16 CAPSIDS WITH ANAL EPIDERMOID CARCINOMA
SO JOURNAL OF THE NATIONAL CANCER INSTITUTE
LA English
DT Article
ID INVASIVE CERVICAL-CANCER; PROTEINS; L1
AB Background: Anal epidermoid carcinoma is a relatively rare tumor, but its incidence has been increasing rapidly during the past few years, Genetic material from the major oncogenic types of human papillomavirus (HPV), types 16 and 18, has regularly been demonstrated in a substantial proportion of anal cancers, suggesting an etiologic role of HPV infection, Recently, serum antibodies against HPV type 16 capsids were shown to be a serologic measure of HPV16 infection. Purpose: We investigated whether serum antibodies against HPV16 capsids are associated with an increased risk of developing anal cancer, Methods: Serum samples from 64 patients (48 women and 16 men) with untreated anal epidermoid cancer and from 79 age- and sex-matched healthy blood donors were analyzed for the levels of serum immunoglobulin G (IgG) against capsids of HPV16 by the enzyme-linked immunosorbent assay, The levels of serum IgG against HPV type 6 and bovine papillomavirus (BPV) capsids, as well as against HPV16 peptide antigens, were also measured, Results: Whereas antibodies against HPV6 or BPV capsids were not significantly associated with anal cancer, the presence of IgG against HPV16 capsids exceeding the anti-BPV antibody levels was demonstrated among 55% (35 of 64) of the case patients but only among 4% (three of 79) of the control subjects (odds ratio [OR] 30.4; 95% confidence interval [CI] = 8.4-161.5), Antibodies against HPV16 E2 and E7 peptides were also more common among case patients (OR = 12.8 and 95% CI = 5.4-31.5 for E2; OR = 3.0 and 95% CI = 1.4-6.7 for E7), Conclusion: The results suggest that HPV16 capsid antibodies are serologic markers for anal cancer, Implication: Exposure to HPV16 or related viruses appears to be a major risk factor in the majority of anal cancers.
C1 KAROLINSKA INST,CTR MICROBIOL & TUMOR BIOL,S-17177 STOCKHOLM,SWEDEN.
SODERSJUKHUSET HOSP,DEPT SURG,STOCKHOLM,SWEDEN.
NCI,DIV CANC BIOL DIAG & CTR,CELLULAR ONCOL LAB,BETHESDA,MD 20892.
NR 18
TC 57
Z9 57
U1 0
U2 1
PU NATL CANCER INSTITUTE
PI BETHESDA
PA 9030 OLD GEORGETOWN RD, BETHESDA, MD 20814
SN 0027-8874
J9 J NATL CANCER I
JI J. Natl. Cancer Inst.
PD MAR 15
PY 1995
VL 87
IS 6
BP 437
EP 440
DI 10.1093/jnci/87.6.437
PG 4
WC Oncology
SC Oncology
GA QL082
UT WOS:A1995QL08200011
PM 7532227
ER
PT J
AU QIN, J
CLORE, GM
KENNEDY, WM
HUTH, JR
GRONENBORN, AM
AF QIN, J
CLORE, GM
KENNEDY, WM
HUTH, JR
GRONENBORN, AM
TI SOLUTION STRUCTURE OF HUMAN THIOREDOXIN IN A MIXED DISULFIDE
INTERMEDIATE COMPLEX WITH ITS TARGET PEPTIDE FROM THE TRANSCRIPTION
FACTOR NF-KAPPA-B
SO STRUCTURE
LA English
DT Article
DE DISULFIDE-BONDED INTERMEDIATE; HUMAN THIOREDOXIN; TRANSCRIPTION FACTOR
NF-KAPPA-B
ID NUCLEAR MAGNETIC-RESONANCE; DNA-BINDING ACTIVITY; HETERONUCLEAR
NMR-SPECTROSCOPY; RESTRAINED MOLECULAR-DYNAMICS; T-CELL LINES; DISTANCE
GEOMETRY; 3-DIMENSIONAL STRUCTURE; RECEPTOR EXPRESSION;
PROTEIN-STRUCTURE; ESCHERICHIA-COLI
AB Background: Human thioredoxin is a 12 kDa cellular redox protein that plays a key role in maintaining the redox environment of the cell. It has recently been shown to be responsible for activating the DNA-binding properties of the cellular transcription factor, NF kappa B, by reducing a disulfide bond involving Cys62 of the p50 subunit. Using multidimensional heteronuclear-edited and heteronuclear-filtered NMR spectroscopy, we have solved the solution structure of a complex of human thioredoxin and a 13-residue peptide extending from residues 56-68 of p50, representing a kinetically stable mixed disulfide intermediate along the reaction pathway.
Results: The NF kappa B peptide is located in a long boot-shaped cleft on the surface of human thioredoxin delineated by the active-site loop, helices alpha 2, alpha 3 and alpha 4, and strands beta 3 and beta 4. The peptide adopts a crescent-like conformation with a smooth 110 degrees bend centered around residue 60 which permits it to follow the path of the cleft.
Conclusions: In addition to the intermolecular disulfide bridge between Cys32 of human thioredoxin and Cys62 of the peptide, the complex is stabilized by numerous hydrogen-bonding, electrostatic and hydrophobic interactions which involve residues 57-65 of the NF kappa B peptide and confer substrate specificity. These structural features permit one to suggest the specificity requirements for human thioredoxin-catalyzed disulfide bond reduction of proteins.
C1 NIDDKD,CHEM PHYS LAB,BETHESDA,MD 20892.
RI Clore, G. Marius/A-3511-2008
OI Clore, G. Marius/0000-0003-3809-1027
NR 85
TC 192
Z9 195
U1 1
U2 2
PU CURRENT BIOLOGY LTD
PI LONDON
PA 34-42 CLEVELAND STREET, LONDON, ENGLAND W1P 6LB
SN 0969-2126
J9 STRUCTURE
JI Structure
PD MAR 15
PY 1995
VL 3
IS 3
BP 289
EP 297
DI 10.1016/S0969-2126(01)00159-9
PG 9
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA QP156
UT WOS:A1995QP15600008
PM 7788295
ER
PT J
AU GAO, WS
CONNOR, HD
LEMASTERS, JJ
MASON, RP
THURMAN, RG
AF GAO, WS
CONNOR, HD
LEMASTERS, JJ
MASON, RP
THURMAN, RG
TI PRIMARY NONFUNCTION OF FATTY LIVERS PRODUCED BY ALCOHOL IS ASSOCIATED
WITH A NEW, ANTIOXIDANT-INSENSITIVE FREE-RADICAL SPECIES
SO TRANSPLANTATION
LA English
DT Article
ID RAT-LIVER; TRANSPLANTATION; INJURY; REPERFUSION; STORAGE
AB The formation of free radicals after orthotopic liver transplantation in the rat correlates with graft failure. Fatty livers from alcoholics transplant poorly, so these studies were designed to examine the effect of alcohol on free radical formation in a rearterialized rat liver transplantation model. Treatment of rats for 3-5 weeks with either a high-fat or an ethanol-containing liquid diet caused characteristic pericentral lipid accumulation. After storage in University of Wisconsin cold storage solution (UW) and transplantation, a reperfusion injury characterized by increased postoperative AST levels (greater than 1500 U/l in about 3 hours) was observed in rats fed high-fat or alcohol-containing diets, whereas parenchymal cell injury was seen much less in low-fat controls. Survival was around 63% in the low-fat group but decreased to 12 and 18% in the high-fat and alcohol groups, respectively. Furthermore, intracellular lipid content correlated inversely with survival. In untransplanted livers, the spin trap alpha-phenyl N-tert-butylnitrone (PBN) was infused, and blood samples were collected and extracted with chloroform:methanol. Signals indicative of carbon-centered PBN radical adducts were barely detectable in all untransplanted groups studied by electron paramagnetic resonance. In contrast, a robust 6-line complex spectrum was obtained from all groups studied immediately after 48 hours of cold storage in UW solution and transplantation. A mixture of 3 radical species was identified. Two had coupling constants similar to lipid-derived free radicals, whereas the third is a new species with unique coupling constants and is most likely oxygen derived. In low-fat controls, the signal was reduced significantly by superoxide dismutase (SOD)/catalase; however, SOD/catalase had no effect on free radicals in lipid-loaded livers. Thus, both dietary high fat and alcohol exposure produce a unique SOD/catalase-insensitive free radical species that may be involved in the mechanism of failure of fatty livers after orthotopic liver transplantation.
C1 UNIV N CAROLINA,FLOB,DEPT PHARMACOL,HEPATOBIOL & TOXICOL LAB,CHAPEL HILL,NC 27599.
KENTUCKY WESLEYAN COLL,DEPT CHEM,OWENSBORO,KY 42301.
UNIV N CAROLINA,CURRICULUM TOXICOL,CHAPEL HILL,NC 27599.
UNIV N CAROLINA,DEPT CELL BIOL & ANAT,CHAPEL HILL,NC 27599.
NIEHS,MOLEC BIOPHYS LAB,RES TRIANGLE PK,NC 27709.
FU NIAAA NIH HHS [AA-09156]; NIEHS NIH HHS [5T32ESO7126]
NR 15
TC 54
Z9 55
U1 0
U2 0
PU WILLIAMS & WILKINS
PI BALTIMORE
PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436
SN 0041-1337
J9 TRANSPLANTATION
JI Transplantation
PD MAR 15
PY 1995
VL 59
IS 5
BP 674
EP 679
DI 10.1097/00007890-199503150-00005
PG 6
WC Immunology; Surgery; Transplantation
SC Immunology; Surgery; Transplantation
GA QM656
UT WOS:A1995QM65600005
PM 7886790
ER
PT J
AU MAHONEY, CW
HUANG, KP
AF MAHONEY, CW
HUANG, KP
TI SELECTIVE PHOSPHORYLATION OF CATIONIC POLYPEPTIDE AGGREGATED WITH
PHOSPHATIDYLSERINE DIACYLGLYCEROL CA2+ DETERGENT MIXED MICELLES BY
CA2+-INDEPENDENT BUT NOT CA2+-DEPENDENT PROTEIN-KINASE-C ISOZYMES
SO BIOCHEMISTRY
LA English
DT Article
ID PHORBOL ESTER-BINDING; QUANTITATIVE MEASUREMENT; MEMBRANE PHOSPHOLIPIDS;
MOLECULAR-CLONING; ACTIVATION; SPECIFICITY; CALCIUM; SUBSTRATE; FAMILY;
BRAIN
AB Mixed micelles containing Nonidet P40 (NP-40) (829 mu M or 4.8 mM), phosphatidylserine (PS) (14.5 or 8 mol %), and 1,2-diacylglycerol (DG) (0.5 or 1 mol %) when preincubated with protein kinase C (PKC) assay mixture containing cationic substrate and CaCl2 (400 mu M) formed aggregates in a time-, temperature-, and substrate concentration-dependent manner with a t(1/2) similar to 3-12 min (22 degrees C). Concomitant with the formation of these aggregates there was a substantial loss of substrate phosphorylation catalyzed by the Ca2+-dependent PKC alpha, beta, and gamma but not the Ca2+-independent PKC delta and E. All cationic PKC substrates tested, neurogranin peptide analog(29-47), neurogranin, and histone III-S, formed aggregates with PS/DG/NP-40/Ca2+ mixed micelles in a time-dependent fashion. The poly(cationic-anionic) PKC substrate protamine sulfate also forms aggregates with the mixed micelles in the presence of Ca2+, but without affecting the substrate phosphorylation by the kinase. Under similar conditions, but at 4 degrees C, neither aggregation nor loss of cationic substrate phosphorylation was observed. Another nonionic detergent, octyl glucoside, behaved similarly to NP-40. Phosphatidylinositol (PI) and phosphatidylglycerol like PS, were effective in forming aggregates with NP-40/cationic polypeptide/DG/Ca2+ as monitored by light scattering, yet without affecting substrate phosphorylation. Phosphorylation of cationic substrates by M-kinase, derived from trypsinized PKC beta, was also greatly diminished by the aggregation. In contrast, [H-3]phorbol 12,13-dibutyrate binding to PKC beta was unaffected. Formation of the aggregates that were selectively utilized by the Ca2+-independent PKCs was dependent on the ratio of cationic substrate to the number of mixed micelles. Lipid vesicles containing PS and DG or a phospholipid composition mimicking that of the cell membrane, phosphatidylcholine/phosphatidylethanolamine/sphingomyelin/PI/PS (247, 1 27, 120, 47, and 40 mu g/mL), 80 mu g/ml DG, and Ca2+, did not form such aggregates in the absence of nonionic detergent. These results indicate that the aggregation of cationic polypeptide with nonionic detergent/PS/DG/Ca2+ renders the substrate phosphorylation sites inaccessible to the Ca2+-dependent subgroup of PKCs. The current findings suggest caution in the use of cationic polypeptides that form aggregates with phospholipid/nonionic detergent/Ca2+ mixed micelles in the assay of Ca2+-dependent PKCs.
C1 NICHHD,ENDOCRINOL & REPROD RES BRANCH,METAB REGULAT SECT,BETHESDA,MD 20892.
NR 48
TC 11
Z9 11
U1 0
U2 1
PU AMER CHEMICAL SOC
PI WASHINGTON
PA PO BOX 57136, WASHINGTON, DC 20037-0136
SN 0006-2960
J9 BIOCHEMISTRY-US
JI Biochemistry
PD MAR 14
PY 1995
VL 34
IS 10
BP 3446
EP 3454
DI 10.1021/bi00010a037
PG 9
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QM333
UT WOS:A1995QM33300037
PM 7533539
ER
PT J
AU LI, X
WISTOW, GJ
PIATIGORSKY, J
AF LI, X
WISTOW, GJ
PIATIGORSKY, J
TI LINKAGE AND EXPRESSION OF THE ARGININOSUCCINATE LYASE DELTA-CRYSTALLIN
GENES OF THE DUCK - INSERTION OF A CR-1 ELEMENT IN THE INTERGENIC SPACER
SO BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
LA English
DT Article
DE ARGININOSUCCINATE LYASE; DELTA-CRYSTALLIN; CR-1; GENE EXPRESSION; LENS;
ENHANCER; (DUCK)
ID CHICKEN DELTA-1-CRYSTALLIN GENE; LENS CRYSTALLINS; NONSPECIFIC ELEMENTS;
ENHANCER ELEMENTS; NONLENS TISSUES; MESSENGER-RNA; SEQUENCE; DNA;
RECRUITMENT; BINDING
AB delta-Crystallin is the major component of the lenses of most birds and reptiles. In the chicken there are two closely linked, tandemly oriented genes. Almost all of the delta-crystallin of the embryonic chicken lens is produced by the 5' delta 1 gene. This high lens activity has been attributed to an enhancer in intron 3. The 3' delta 2 gene encodes the enzyme argininosuccinate lyase (ASL) which is expressed at a low level in the chicken lens. Both chicken delta-crystallin genes are also expressed slightly in heart and brain, with ASL/delta 2 predominating over delta 1. In the duck (Anas platyrhynchos), ASL/delta 2-crystallin serves as both enzyme and crystallin, resulting in very high levels of ASL activity in the lens. Here we show by genomic cloning that the ASL/delta-crystallin locus is highly conserved between duck and chicken, with the two duck delta-crystallin genes closely linked in tandem. The 4.6 kbp intergenic spacer in the duck locus is 79% identical to the 4 kbp chicken spacer, except for the existence of a 615 bp CR1 element, highly reiterated in the duck genome, 1.8 kbp upstream of the duck ASL/delta 2 gene. The CRI sequence is a truncated LINE element containing the 3' half of an open reading frame for a retroviral pol-reverse transcriptase. Sequence analysis revealed (i) that intron 3 of the duck ASL/delta 2 gene is very similar (80%) to intron 3 of the chicken delta 1 and ASL/delta 2 gene, especially in the region of the chicken delta 1 enhancer core (93% identical) and (ii) that the 3' boundary of exon 2 of the duck ASL/delta 2 gene has undergone a recent splice-site slippage event, resulting in a two amino acid insertion in the encoded polypeptide. Finally, reverse transcription/polymerase chain reaction experiments established that both delta-crystallin genes are equally expressed to a high level in the embryonic duck lens; by contrast, both delta-crystallin genes produce a low amount of mRNA in the heart and brain of the embryonic duck, with the enzymatically active ASL/delta 2 being preferentially expressed.
C1 NEI,MOLEC GENET SECT,MOLEC & DEV BIOL LAB,BETHESDA,MD 20892.
NEI,MOLEC STRUCT & FUNCT SECT,MOLEC & DEV BIOL LAB,BETHESDA,MD 20892.
NR 50
TC 8
Z9 9
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-4781
J9 BBA-GENE STRUCT EXPR
JI Biochim. Biophys. Acta-Gene Struct. Expression
PD MAR 14
PY 1995
VL 1261
IS 1
BP 25
EP 34
DI 10.1016/0167-4781(94)00211-K
PG 10
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA QM534
UT WOS:A1995QM53400003
PM 7893758
ER
PT J
AU DUNCAN, MK
ROTH, HJ
THOMPSON, M
KANTOROW, M
PIATIGORSKY, J
AF DUNCAN, MK
ROTH, HJ
THOMPSON, M
KANTOROW, M
PIATIGORSKY, J
TI CHICKEN BETA-B1 CRYSTALLIN - GENE SEQUENCE AND EVIDENCE FOR FUNCTIONAL
CONSERVATION OF PROMOTER ACTIVITY BETWEEN CHICKEN AND MOUSE
SO BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
LA English
DT Article
DE CRYSTALLIN; IN VIVO FOOTPRINTING; TRANSGENIC MOUSE; GENE REGULATION;
LENS; EYE
ID LENS-SPECIFIC EXPRESSION; TRANSGENIC MICE; DELTA-CRYSTALLIN; GLOBIN
GENE; PROTEINS; EVOLUTION; ENHANCER; CELLS; FAMILY; REGION
AB The complete sequence was determined for the chicken beta B1-crystallin gene and 2.2 kbp of its 5' flanking region; the chicken gene was then compared to its rat orthololog. Although both have a 5' non-coding exon followed by 5 protein coding exons, the chicken gene is only 2.2 kbp while the rat gene is 13.6 kpb due to longer introns. The coding exons of the chicken beta B1-crystallin gene, like those or the rat and other beta-crystallin genes, each correspond to one of the four 'Greek key' motifs of the encoded protein. The only obvious similarity between the 5' flanking sequences of the chicken and rat beta B1-crystallin gene is associated with the TATA box. A CR1 repetitive element is present at positions -559 to -730 of the chicken beta B1-crystallin gene. In vivo footprinting using dimethyl sulfate/ligation mediated PCR showed that the PL-1 (-116/-102), PL-2 (-90/-76), OL-2 (-75/-68) and OL-1 (-125/-118) control elements identified previously (Roth et al. (1991) Mol. Cell. Biol. 11, 1488-1499) bind proteins within the chromatin of cultured embryonic chicken lens cells. Both -2448/+30 and -434/+30 promoter fragments from the chicken beta B1-crystallin gene directed lens-specific CAT gene expression in a copy number and position independent manner in transgenic mice. These data indicate that the structure and lens-specific expression of this gene are highly conserved although, like other crystallin genes, the 5' flanking sequences have diverged appreciably during evolution.
C1 NEI, MOLEC & DEV BIOL LAB, BETHESDA, MD 20892 USA.
NR 33
TC 36
Z9 37
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-4781
J9 BBA-GENE STRUCT EXPR
JI Biochim. Biophys. Acta-Gene Struct. Expression
PD MAR 14
PY 1995
VL 1261
IS 1
BP 68
EP 76
DI 10.1016/0167-4781(94)00223-P
PG 9
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA QM534
UT WOS:A1995QM53400007
PM 7893762
ER
PT J
AU CORYELL, W
ENDICOTT, J
MASER, JD
MUELLER, T
LAVORI, P
KELLER, M
AF CORYELL, W
ENDICOTT, J
MASER, JD
MUELLER, T
LAVORI, P
KELLER, M
TI THE LIKELIHOOD OF RECURRENCE IN BIPOLAR AFFECTIVE-DISORDER - THE
IMPORTANCE OF EPISODE RECENCY
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
ID PROSPECTIVE FOLLOW-UP; MANIA; PROPHYLAXIS; LITHIUM; CARBAMAZEPINE;
DEPRESSION; UNIPOLAR
AB These analyses used a high-intensity follow-up of of patients with bipolar affective disorder to describe the immediate and long-term risks for recurrence and the importance of sustained recovery to those risks. At the baseline evaluation, all patients were in episodes of Research Diagnostic Criteria major depressive disorder, mania or schizoaffective disorder (excluding the mainly schizophrenic subtype); those who were depressed at intake had a history of mania or schizoaffective mania. Raters re-evaluated these patients at 6-month intervals for 5 years and annually for the remainder of a 10-year follow-up. The following report describes relapse risks for the 186 patients observed to recover from their index episodes. Survival analyses quantified the likelihood of relapse over time, beginning after symptom-free periods of 4 months and 1, 2 and 3 years. Further survival analyses used treatment status as a censoring variable to estimate the eventual likelihood of recurrence among those who reported sustained compliance with lithium prophylaxis; the prophylaxis group remained under observation until they relapsed, were lost to follow-up or ceased taking lithium. Progressively longer symptom-free periods were clearly associated with lower relapse risks over the subsequent 4 years. Thereafter, however, this effect dissipitated. 7 years after recovery, the cumulative likelihood of recurrence was four in five for all bipolar patients and two in three for those whose index episode had been followed by at least 3 years without symptoms. Even with sustained lithium prophylaxis, the likelihood of at least one recurrence exceeded 70% within 5 years of recovery. The preexisting length of symptom-free periods in bipolar affective disorder can be used to predict risks for recurrence over a subsequent 4-year period. The eventual likelihood of recurrence remains quite high though, even with lithium prophylaxis.
RP CORYELL, W (reprint author), NIMH,COLLABORAT PROGRAM,DEPT PSYCHIAT,2887 JPP,200 HAWKINS DR,IOWA CITY,IA 52242, USA.
FU NIMH NIH HHS [R01 MH025478]
NR 20
TC 44
Z9 44
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
J9 J AFFECT DISORDERS
JI J. Affect Disord.
PD MAR 14
PY 1995
VL 33
IS 3
BP 201
EP 206
DI 10.1016/0165-0327(94)00091-M
PG 6
WC Clinical Neurology; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA QM441
UT WOS:A1995QM44100009
PM 7790673
ER
PT J
AU KEOWN, MB
GHIRLANDO, R
YOUNG, RJ
BEAVIL, AJ
OWENS, RJ
PERKINS, SJ
SUTTON, BJ
GOULD, HJ
AF KEOWN, MB
GHIRLANDO, R
YOUNG, RJ
BEAVIL, AJ
OWENS, RJ
PERKINS, SJ
SUTTON, BJ
GOULD, HJ
TI HYDRODYNAMIC STUDIES OF A COMPLEX BETWEEN THE FC FRAGMENT OF HUMAN IGE
AND A SOLUBLE FRAGMENT OF THE FC-EPSILON-RI ALPHA-CHAIN
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE STOICHIOMETRY; HYDRODYNAMIC MODELING; ALLERGY
ID HIGH-AFFINITY RECEPTOR; IMMUNOGLOBULIN-E; BINDING-SITE;
NEUTRON-SCATTERING; CELL-RECEPTOR; SUBUNIT; PROTEIN; RAT; CONFORMATIONS;
DOMAIN
AB The interaction between immunoglobulin E (IgE) and its high-affinity receptor Fc epsilon RI is central to allergic disease. The binding site for Fc epsilon RI lies in the third constant region domain of the E heavy chain of IgE (C epsilon 3). Identical epitopes on the two C epsilon 3 domains in the IgE-Fc are predicted to be on opposite sides of the structure, and therefore each could bind independently to a receptor molecule. Titrations, however, reveal that the IgE-Fc forms an equimolar complex with a soluble fragment of the Fc epsilon RI alpha chain (sFc epsilon RI alpha), and the molecular weight of the complex, as determined by sedimentation equilibrium, confirms this stoichiometry. The measured sedimentation coefficients of the two ligands are in good agreement with computed values for a compact IgE-Fc and an elongated sFc epsilon RI alpha structure. The calculated sedimentation coefficients for possible models of a 1:1 complex lead to exclusion of all highly extended geometries for the complex. Possible explanations for the paradoxical stoichiometry of the IgE-Fc/sFc epsilon RI alpha complex, in terms of the curved shape of IgE, a conformational change in IgE when the receptor binds, and steric interference between two molecules of Fc epsilon RI binding to identical sites, are discussed.
C1 UNIV LONDON KINGS COLL, RANDALL INST, LONDON WC2B 5RL, ENGLAND.
NIDDKD, BETHESDA, MD 20892 USA.
CELLTECH LTD, SLOUGH SL1 4EN, BERKS, ENGLAND.
ROYAL FREE HOSP, SCH MED, DEPT BIOCHEM & MOLEC BIOL, LONDON NW3 2PF, ENGLAND.
RI Ghirlando, Rodolfo/A-8880-2009; Beavil, Andrew/B-5624-2009
OI Beavil, Andrew/0000-0002-0768-122X
FU Wellcome Trust
NR 32
TC 32
Z9 32
U1 0
U2 0
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAR 14
PY 1995
VL 92
IS 6
BP 1841
EP 1845
DI 10.1073/pnas.92.6.1841
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA QM408
UT WOS:A1995QM40800012
PM 7892188
ER
PT J
AU LAUE, L
CHAN, WY
HSUEH, AJW
KUDO, M
HSU, SY
WU, SM
BLOMBERG, LA
CUTLER, GB
AF LAUE, L
CHAN, WY
HSUEH, AJW
KUDO, M
HSU, SY
WU, SM
BLOMBERG, LA
CUTLER, GB
TI GENETIC-HETEROGENEITY OF CONSTITUTIVELY ACTIVATING MUTATIONS OF THE
HUMAN LUTEINIZING-HORMONE RECEPTOR IN FAMILIAL MALE-LIMITED PRECOCIOUS
PUBERTY
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
ID SEXUAL PRECOCITY; ACTIVE MUTANTS; CELLS; SPIRONOLACTONE; GONADOTROPIN;
TESTOLACTONE; EXPRESSION; LEYDIG; OPSIN; RAT
AB Genomic DNA from 32 unrelated families with male-limited precocious puberty was examined for the previously described Asp-578 --> Gly, Met-571 --> Ile, and Thr-577 --> Ile mutations in transmembrane helix 6 of the human luteinizing hormone receptor (hLHR). Twenty-eight families had the inherited form of the disorder, and of these, 24 were found to have the Asp-578 --> Gly mutation. Four additional mutations were found among the remaining four families with the inherited form and in four sporadic cases of the disorder: an A --> C transversion resulting in substitution or leucine for Ile-542 in the fifth transmembrane helix, an A --> G transition resulting in substitution of glycine for Asp-564 in the third cytoplasmic loop, a G --> T transversion resulting in substitution of tyrosine for Asp-578 in the sixth transmembrane helix, and a T --> C transition resulting in substitution of arginine for Cys-581 in the sixth transmembrane helix. Human embryonic kidney cells transfected with cDNAs for each of the mutant hLHRs, created by PCR-based mutagenesis of the wild-type hLHR cDNA, exhibited increased levels of basal cAMP production in the absence of agonist, indicating constitutive activation of the mutant hLHRs. Three of the additional mutations had specific features: Ile-542 --> Leu and Cys-581 --> Arg appeared ligand-unresponsive, whereas Asp-578 --> Tyr appeared to correlate genotype with phenotype. We conclude that the region spanning nt 1624-1741 of exon 11 is a hotspot for heterogeneous point mutations that constitutively activate the hLHR and cause male-limited precocious puberty.
C1 GEORGETOWN UNIV,MED CTR,DEPT BIOCHEM & CELL BIOL,WASHINGTON,DC 20007.
STANFORD UNIV,MED CTR,DEPT OBSTET & GYNECOL,STANFORD,CA 94305.
NICHHD,DEV ENDOCRINOL BRANCH,BETHESDA,MD 20892.
RP LAUE, L (reprint author), GEORGETOWN UNIV,MED CTR,DEPT PEDIAT,WASHINGTON,DC 20007, USA.
FU NICHD NIH HHS [HD 32644]
NR 28
TC 180
Z9 186
U1 0
U2 2
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAR 14
PY 1995
VL 92
IS 6
BP 1906
EP 1910
DI 10.1073/pnas.92.6.1906
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA QM408
UT WOS:A1995QM40800025
PM 7892197
ER
PT J
AU HAJRA, A
LIU, PP
WANG, Q
KELLEY, CA
STACY, T
ADELSTEIN, RS
SPECK, NA
COLLINS, FS
AF HAJRA, A
LIU, PP
WANG, Q
KELLEY, CA
STACY, T
ADELSTEIN, RS
SPECK, NA
COLLINS, FS
TI THE LEUKEMIC CORE BINDING-FACTOR BETA-SMOOTH MUSCLE MYOSIN HEAVY-CHAIN
(CBF-BETA-SMMHC) CHIMERIC PROTEIN REQUIRES BOTH CBF-BETA AND MYOSIN
HEAVY-CHAIN DOMAINS FOR TRANSFORMATION OF NIH 3T3 CELLS (RETRACTED
ARTICLE. SEE VOL 93, PG 15523, 1996)
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article; Retracted Publication
ID ACUTE MYELOID-LEUKEMIA; POLYOMAVIRUS ENHANCER; NUCLEAR FACTOR; GENE;
AML1; CHROMOSOME-16; ASSOCIATION; FUSION; REGION; DNA
AB An inversion of chromosome 16 associated with the M4Eo subtype of acute myeloid leukemia produces a chimeric protein fusing the beta subunit of the transcription factor core binding factor (CBF beta) to the tail region of smooth muscle myosin heavy chain (SMMHC). We investigated the oncogenic properties of this CBF beta-SMMHC chimeric protein using a 3T3 transformation assay. NIH 3T3 cells expressing CBF beta-SMMHC acquired a transformed phenotype, as indicated by their ability to form foci, grow in soft agarose, and form tumors in nude mice. Cells expressing normal CBF beta or the SMMHC tail domain did not become transformed. Electrophoretic mobility-shift assays showed that extracts from cells transformed by CBF beta-SMMHC no longer formed the normal CBF/DNA complex but instead formed a much larger complex that did not migrate into the gel, Analysis of CBF beta-SMMHC deletion mutants demonstrated that the chimeric protein was transforming only if two domains were both present: (i) CBF beta sequences necessary for association with the CBF alpha subunit, and (ii) SMMHC sequences important for the formation of multimeric filaments, These results are direct evidence that CBF beta-SMMHC can function as an oncoprotein.
C1 NIH, NATL CTR HUMAN GENOME RES, GENE TRANSFER LAB, BETHESDA, MD 20892 USA.
UNIV MICHIGAN, SCH MED, DEPT HUMAN GENET, ANN ARBOR, MI 48109 USA.
DARTMOUTH COLL, SCH MED, DEPT BIOCHEM, HANOVER, NH 03755 USA.
NHLBI, MOLEC CARDIOL LAB, BETHESDA, MD 20892 USA.
RI Liu, Paul/A-7976-2012
OI Liu, Paul/0000-0002-6779-025X
FU NCI NIH HHS [CA58343-01]
NR 33
TC 27
Z9 27
U1 0
U2 3
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAR 14
PY 1995
VL 92
IS 6
BP 1926
EP 1930
DI 10.1073/pnas.92.6.1926
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA QM408
UT WOS:A1995QM40800029
PM 7892201
ER
PT J
AU SLEDJESKI, D
GOTTESMAN, S
AF SLEDJESKI, D
GOTTESMAN, S
TI SMALL RNA ACTS AS AN ANTISILENCER OF THE H-NS-SILENCED RCSA GENE OF
ESCHERICHIA-COLI
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE DSRA; LON; TRANSCRIPTION INITIATION; CAPSULE SYNTHESIS
ID CAPSULAR POLYSACCHARIDE SYNTHESIS; CURVED DNA; PROTEIN; EXPRESSION;
OPERON; THERMOREGULATION; BACTERIOPHAGE-T4; GROWTH; K-12; K12
AB The regulation of capsular polysaccharide synthesis in Escherichia coli K-12 depends on the level of an unstable positive regulator, RcsA. The amount of RcsA protein is limited both by its rapid degradation by Lon, an ATP-dependent protease, and by its low level of synthesis. We have found that the low level of expression from the rcsA promoter is due to transcriptional silencing by the histone-like protein H-NS; this silencing is sensitive to both sequence and context in a region upstream of the -35 region of the promoter. A small (85-nt) RNA, DsrA, when overproduced, activates transcription of rcsA::lacZ fusions by counteracting H-NS silencing. DsrA RNA does not show any extended homology with the rcsA promoter or other sequenced regions of E. coli. Since the stimulation of rcsA transcription by this small RNA does not depend on any sequences from within the rcsA transcript, DsrA acts, either directly or indirectly, on rcsA transcription initiation.
C1 NCI, MOLEC BIOL LAB, BETHESDA, MD 20892 USA.
OI Sledjeski, Darren/0000-0001-9882-6625
FU NIGMS NIH HHS [F32GM14776-01]
NR 47
TC 157
Z9 163
U1 1
U2 4
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAR 14
PY 1995
VL 92
IS 6
BP 2003
EP 2007
DI 10.1073/pnas.92.6.2003
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA QM408
UT WOS:A1995QM40800045
PM 7534408
ER
PT J
AU KIMURA, Y
STADTMAN, TC
AF KIMURA, Y
STADTMAN, TC
TI GLYCINE REDUCTASE SELENOPROTEIN-A IS NOT A GLYCOPROTEIN - THE POSITIVE
PERIODIC ACID SCHIFF REAGENT TEST IS THE RESULT OF PEPTIDE-BOND CLEAVAGE
AND CARBONYL GROUP GENERATION
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE PERIODIC ACID OXIDATION; GLYCOPROTEIN ANALYSIS
ID PURIFICATION; COMPLEX; SELENOCYSTEINE; COMPONENT; SEQUENCE; PROTEINS;
SYSTEM; GENE
AB The complete amino acid sequence of Clostridium sticklandii selenoprotein A, a selenocysteine-containing protein component of the glycine reductase complex, has been established. Both the intact protein and peptide fragments produced by Staphylococcus aureus V8 protease or trypsin were purified by reversed-phase high-performance liquid chromatography and subjected to electrospray ionization mass spectrometric analysis and standard Edman degradation. Selenoprotein A consists of 157 amino acids with a chemical molecular weight of 17,011, in reasonable agreement with the observed molecular weight (17,022.7) determined from its ionization mass spectrum. The sequence of the amino-terminal region of the isolated native protein is Ser-Arg-Phe-Thr-Gly-Lys-Lys-Ile-Val-Ile-Ile-Gly-Asp-Arg-Asp-. An N-terminal methionine residue deduced from the gene sequence was not present. Although selenoprotein A reacted positively in a glycoprotein stain when using either the periodic acid-Schiff reagent procedure or a commercial glycan detection kit, no saccharide was detected by carbohydrate analyses after acid hydrolysis or methanolysis. Identity of the amino acid sequence determined by analysis with that deduced from the gene sequence is further evidence of the absence of bound carbohydrate.
C1 NHLBI,IR,BIOCHEM LAB,BETHESDA,MD 20892.
NR 19
TC 16
Z9 18
U1 0
U2 0
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAR 14
PY 1995
VL 92
IS 6
BP 2189
EP 2193
DI 10.1073/pnas.92.6.2189
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA QM408
UT WOS:A1995QM40800083
PM 7892245
ER
PT J
AU SHIRASAKA, T
KAVLICK, MF
UENO, T
GAO, WY
KOJIMA, E
ALCAIDE, ML
CHOKEKIJCHAI, S
ROY, BM
ARNOLD, E
YARCHOAN, R
MITSUYA, H
AF SHIRASAKA, T
KAVLICK, MF
UENO, T
GAO, WY
KOJIMA, E
ALCAIDE, ML
CHOKEKIJCHAI, S
ROY, BM
ARNOLD, E
YARCHOAN, R
MITSUYA, H
TI EMERGENCE OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VARIANTS WITH
RESISTANCE TO MULTIPLE DIDEOXYNUCLEOSIDES IN PATIENTS RECEIVING THERAPY
WITH DIDEOXYNUCLEOSIDES
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE MULTIDRUG RESISTANCE; REVERSE TRANSCRIPTASE; DNTP-BINDING SITE
ID HIV-1 REVERSE-TRANSCRIPTASE; ZIDOVUDINE AZT; SENSITIVITY; INHIBITORS;
INFECTION; MUTATION
AB A set of mutations [Ala-62 --> Val(A62V), V75I, F77L, F116Y, and Q151M] in the polymerase domain of reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) confers on the virus a reduced sensitivity to multiple antiretroviral dideoxynucleosides and has been seen in HIV-1 variants isolated from patients receiving combination chemotherapy with 3'-azido-3'-deoxythymidine (AZT) plus 2',3'-dideoxycytidine (ddC) or 2',3'-dideoxyinosine (ddI). The IC50 values of AZT, ddC, ddI, 2',3'-dideoxyguanosine, and 2',3'-didehydro-3'-deoxythymidine against an infectious clone constructed to include the five mutations were significantly higher than those of a wild-type infectious clone. The K-i value for AZT 5'-triphosphate determined for the virus-associated RT from a posttherapy strain was 35-fold higher than that of RT from a pretherapy strain. Detailed analysis of HIV-1 strains isolated at various times during therapy showed that the Q151M mutation developed first in vivo, at the time when the viremia level suddenly increased, followed by the F116Y and F77L mutations. All five mutations ultimately developed, and the viremia level rose even further. Analyses based on the three-dimensional structure of HIV-1 RT suggest that the positions where at least several of the five mutations occur are located in close proximity to the proposed dNTP-binding site of RT and the first nucleotide position of the single-stranded template.
C1 NCI,MED BRANCH,EXPTL RETROVIROL SECT,BETHESDA,MD 20892.
NCI,RETROVIRAL DIS SECT,BETHESDA,MD 20892.
RUTGERS STATE UNIV,CTR ADV BIOTECHNOL & MED,PISCATAWAY,NJ 08854.
RUTGERS STATE UNIV,DEPT CHEM,PISCATAWAY,NJ 08854.
RI Ueno, Takamasa/F-5788-2013
OI Ueno, Takamasa/0000-0003-4852-4236
FU NIAID NIH HHS [AI27690, AI36144]
NR 30
TC 338
Z9 342
U1 0
U2 3
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAR 14
PY 1995
VL 92
IS 6
BP 2398
EP 2402
DI 10.1073/pnas.92.6.2398
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA QM408
UT WOS:A1995QM40800126
PM 7534421
ER
PT J
AU ANDERSSON, HC
PARRY, DM
MULVIHILL, JJ
AF ANDERSSON, HC
PARRY, DM
MULVIHILL, JJ
TI LYMPHANGIOSARCOMA IN LATE-ONSET HEREDITARY LYMPHEDEMA - CASE-REPORT AND
NOSOLOGICAL IMPLICATIONS
SO AMERICAN JOURNAL OF MEDICAL GENETICS
LA English
DT Article
DE HEREDITARY LYMPHEDEMA; LYMPHANGIOSARCOMA; MEIGE DISEASE
AB Hereditary lymphedemas that are not associated with other malformations usually affect the lower limbs and are inherited in an autosomal dominant fashion. These nonsyndromic hereditary lymphedemas are categorized by their age of onset, being either congenital (Milroy disease) or having an onset in childhood or around puberty (Meige disease). We describe a family in which three individuals in three generations had unusually late onset of lymphedema in their mid-twenties or thirties. The proband additionally developed a very rare lymphangiosarcoma. This tumor, usually associated with post-mastectomy lymphedema, has not been described in late-onset hereditary lymphedema. Because of an unusually high incidence of multiple primary tumors in association with lymphangiosarcoma in the literature (approximately 10%) and proband's own familial cancer background, we speculate that an inherited predisposition to malignancy may underlie the development of lymphedema-associated lymphangiosarcoma. (C) 1995 Wiley-Liss, Inc.
C1 NCI,INTERINST MED GENET PROGRAM,BETHESDA,MD 20892.
NCI,CLIN EPIDEMIOL BRANCH,BETHESDA,MD 20892.
UNIV PITTSBURGH,DEPT HUMAN GENET,PITTSBURGH,PA.
RP ANDERSSON, HC (reprint author), TULANE UNIV,MED CTR,HAYWARD GENET CTR,1430 TULANE AVE,NEW ORLEANS,LA 70112, USA.
NR 19
TC 10
Z9 11
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0148-7299
J9 AM J MED GENET
JI Am. J. Med. Genet.
PD MAR 13
PY 1995
VL 56
IS 1
BP 72
EP 75
DI 10.1002/ajmg.1320560116
PG 4
WC Genetics & Heredity
SC Genetics & Heredity
GA QJ893
UT WOS:A1995QJ89300015
PM 7747790
ER
PT J
AU MILLER, RW
RUBINSTEIN, JH
AF MILLER, RW
RUBINSTEIN, JH
TI TUMORS IN RUBINSTEIN-TAYBI SYNDROME
SO AMERICAN JOURNAL OF MEDICAL GENETICS
LA English
DT Article
DE RUBINSTEIN-TAYBI SYNDROME; NEOPLASMS; BRAIN TUMORS; GERM CELL TUMORS;
CONGENITAL ANOMALIES
ID CONGENITAL-ANOMALIES
AB The 14 tumors reported in Rubinstein-Taybi syndrome since 1989, when added to the 22 previously reported, are beginning to show a pattern of neural and developmental tumors, especially of the head, which is malformed in the syndrome. Among the neoplasms were 12 of the nervous systems: 2 each of oligodendroglioma, medulloblastoma, neuroblastoma, and benign meningioma, a pheochromocytoma, and 3 other benign tumors; 2 of nasopharyngeal rhabdomyosarcoma; and 1 each of leiomyosarcoma, seminoma, and embryonal carcinoma. Among the other benign tumors were an odontoma, a choristoma, a dermoid cyst, and 2 pilomatrixomas. (C) 1995 Wiley-Liss, Inc.
C1 UNIV CINCINNATI,AFFILIATED CTR DEV DISORDERS,CINCINNATI,OH.
UNIV CINCINNATI,COLL MED,DEPT PEDIAT,CINCINNATI,OH.
CHILDRENS HOSP,MED CTR,CINCINNATI,OH 45229.
RP MILLER, RW (reprint author), NCI,CLIN EPIDEMIOL BRANCH,EPN 400,BETHESDA,MD 20892, USA.
FU PHS HHS [MCJ-399156-04-1]
NR 20
TC 164
Z9 172
U1 0
U2 1
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0148-7299
J9 AM J MED GENET
JI Am. J. Med. Genet.
PD MAR 13
PY 1995
VL 56
IS 1
BP 112
EP 115
DI 10.1002/ajmg.1320560125
PG 4
WC Genetics & Heredity
SC Genetics & Heredity
GA QJ893
UT WOS:A1995QJ89300024
PM 7747773
ER
PT J
AU MEMON, SA
PETRAK, D
MORENO, MB
ZACHARCHUK, CM
AF MEMON, SA
PETRAK, D
MORENO, MB
ZACHARCHUK, CM
TI A SIMPLE ASSAY FOR EXAMINING THE EFFECT OF TRANSIENTLY EXPRESSED GENES
ON PROGRAMMED CELL-DEATH
SO JOURNAL OF IMMUNOLOGICAL METHODS
LA English
DT Article
DE APOPTOSIS; BCL-2; TRANSIENT TRANSFECTION
ID MYELOID LEUKEMIC-CELLS; INDUCED APOPTOSIS; C-MYC; THYMOCYTE APOPTOSIS;
BETA-GALACTOSIDASE; TRANSGENIC MICE; CYCLE BLOCK; BCL-2; ACTIVATION; P53
AB Programmed cell death (PCD) has been observed in a wide variety of cell types in response to physiologic signals or types of stress. How these stimuli trigger PCD, and whether there is a common PCD signal transduction pathway, is not clear. As more genes are described that may participate in or regulate PCD, an assay system in which gene products can easily be introduced and/or modulated would be of great value. To avoid the generation and screening of multiple individual stable cell transfectants, a simple transient transfection death assay has been developed. 2B4.11, a murine T cell hybridoma, was transfected by electroporation with a constitutively active P-galactosidase reporter gene and the cells were incubated in culture medium or with a PCD-inducing stimulus. The amount of P-galactosidase activity remaining in the intact cells at the end of the culture period represented only viable transfected cells. Bcl-2 was chosen to examine whether this system would be useful to study the effect of transiently transfected genes since it blocks PCD in a number of experimental systems. Consistent with data obtained using stable transfectants, transient expression of Bcl-2 in 2B4.11 completely protected cells from glucocorticoid- and cytotoxic agent-induced PCD. This protection from death was confirmed at the individual cell level by the transient co-expression of a class I L(d) surface antigen and flow cytometric analysis. Some of the advantages of the transient transfection death assay described here are; (1) the simple and sensitive beta-galactosidase assay, (2) the rapidity of the assay, (3) the ability to perform conventional viability assays to monitor treatment-induced cytotoxicity, (4) multiple gene products can be tested alone, and in combination, (5) antisense or dominant negative approaches can be used, and (6) the adaptability of this assay system to other cell types, transfection techniques, or reporter and expression vectors. The transient transfection death assay should make it easier to identify and order important steps in the PCD signal transduction pathways.
C1 NCI,IMMUNE CELL BIOL LAB,BIOL RESPONSE MODIFIERS PROGRAM,BETHESDA,MD 20892.
RI Memon, Sarfraz/E-1198-2013
NR 40
TC 33
Z9 33
U1 0
U2 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-1759
J9 J IMMUNOL METHODS
JI J. Immunol. Methods
PD MAR 13
PY 1995
VL 180
IS 1
BP 15
EP 24
DI 10.1016/0022-1759(94)00294-7
PG 10
WC Biochemical Research Methods; Immunology
SC Biochemistry & Molecular Biology; Immunology
GA QM770
UT WOS:A1995QM77000002
PM 7897244
ER
PT J
AU MAGRATH, I
AF MAGRATH, I
TI BONE-MARROW TRANSPLANTATION FOR LEUKEMIA - A LAME STALKING HORSE FOR USE
OF HIGH-TECHNOLOGY MEDICAL-CARE
SO LANCET
LA English
DT Editorial Material
RP MAGRATH, I (reprint author), NIH,LYMPHOMA BIOL SECT,BETHESDA,MD 20892, USA.
NR 6
TC 4
Z9 4
U1 1
U2 1
PU LANCET LTD
PI LONDON
PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL
SN 0099-5355
J9 LANCET
JI Lancet
PD MAR 11
PY 1995
VL 345
IS 8950
BP 601
EP 602
DI 10.1016/S0140-6736(95)90516-2
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA QM075
UT WOS:A1995QM07500004
PM 7898174
ER
PT J
AU STOLOW, DT
HAYNES, SR
AF STOLOW, DT
HAYNES, SR
TI CABEZA, A DROSOPHILA GENE ENCODING A NOVEL RNA-BINDING PROTEIN, SHARES
HOMOLOGY WITH EWS AND TLS, 2 GENES INVOLVED IN HUMAN SARCOMA FORMATION
SO NUCLEIC ACIDS RESEARCH
LA English
DT Article
ID NUCLEAR RIBONUCLEOPROTEIN PARTICLE; HEAD-SPECIFIC GENES; ON-TRANSIENT-A;
MOLECULAR ANALYSIS; SEX-LETHAL; CONSENSUS SEQUENCE; RIBOSOMAL-PROTEINS;
PREMESSENGER RNA; X-CHROMOSOME; EXPRESSION
AB We have previously described a partial Drosophila cDNA, clone P19, which bears homology to members of the RNA recognition motif (RRM) family of proteins [Haynes et al. (1987) Proc. Natl. Acad. Sci. USA, 84, 1819-1823]. RNA binding as well as involvement in RNA processing has been demonstrated for some RRM proteins. We report here the further characterization of P19, which we renamed cabeza (caz). caz is located on the X chromosome at position 14B. Using Northern analysis, at least four transcripts from the caz gene were observed at varying revels during development, caz mRNA and protein are enriched in the brain and central nervous system during embryogenesis. In addition, the protein is enriched in the adult head. UV crosslinking was used to demonstrate in vitro RNA binding activity for full-length recombinant caz protein and for the caz RRM domain. Sequence analysis revealed caz is related to two human genes, EWS and TLS, which are involved in chromosomal translocations. The fusion of EWS and TLS to other cellular genes results in sarcoma formation. In addition to their overall structural organization and sequence similarity, these three genes share an RRM which is divergent from typical RRMs. Therefore, it appears that these genes constitute a new sub-family of RNA binding proteins.
C1 NICHHD,MOLEC GENET LAB,BETHESDA,MD 20892.
NR 69
TC 43
Z9 47
U1 0
U2 1
PU OXFORD UNIV PRESS UNITED KINGDOM
PI OXFORD
PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP
SN 0305-1048
J9 NUCLEIC ACIDS RES
JI Nucleic Acids Res.
PD MAR 11
PY 1995
VL 23
IS 5
BP 835
EP 843
DI 10.1093/nar/23.5.835
PG 9
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QQ184
UT WOS:A1995QQ18400018
PM 7708500
ER
PT J
AU VOELLER, DM
CHANGCHIEN, LM
MALEY, GF
MALEY, F
TAKECHI, T
TURNER, RE
MONTFORT, WR
ALLEGRA, CJ
CHU, E
AF VOELLER, DM
CHANGCHIEN, LM
MALEY, GF
MALEY, F
TAKECHI, T
TURNER, RE
MONTFORT, WR
ALLEGRA, CJ
CHU, E
TI CHARACTERIZATION OF A SPECIFIC INTERACTION BETWEEN ESCHERICHIA-COLI
THYMIDYLATE SYNTHASE AND ESCHERICHIA-COLI THYMIDYLATE SYNTHASE
MESSENGER-RNA
SO NUCLEIC ACIDS RESEARCH
LA English
DT Article
ID MESSENGER-RNA TRANSLATION; 3' UNTRANSLATED REGION; BINDING-SITE;
NUCLEOTIDE-SEQUENCE; DNA-POLYMERASE; PROTEIN; IDENTIFICATION; FERRITIN;
INVITRO; ENZYME
AB Previous studies have shown that human TS mRNA translation is controlled by a negative autoregulatory mechanism. In this study, an RNA electrophoretic gel mobility shift assay confirmed a direct interaction between Escherichia coli (E.coli) TS protein and its own E.coli TS mRNA. Two cis-acting sequences in the E.coli TS mRNA protein-coding region were identified, with one site corresponding to nucleotides 207-460 and the second site corresponding to nucleotides 461-807. Each of these mRNA sequences bind TS with a relative affinity similar to that of the full-length E.coli TS mRNA sequence (IC50 = 1 nM). A third binding site was identified, corresponding to nucleotides 808-1015, although its relative affinity for TS (IC50 = 5.1 nM) was lower than that of the other two cis-acting elements. E.coli TS proteins with mutations in amino acids located within the nucleotide-binding region retained the ability to bind RNA while proteins with mutations at either the nucleotide active site cysteine (C146S) or at amino acids located within the folate-binding region were unable to bind TS mRNA. These studies suggest that the regions on E.coli TS defined by the folate-binding site and/or critical cysteine sulfhydryl groups may represent important RNA binding domains. Further evidence is presented which demonstrates that the direct interaction with TS results in in vitro repression of E.coli TS mRNA translation.
C1 NCI, USN, MED ONCOL BRANCH, BETHESDA, MD 20889 USA.
NEW YORK STATE DEPT HLTH, WADSWORTH CTR, ALBANY, NY 12201 USA.
UNIV ARIZONA, DEPT BIOCHEM, TUCSON, AZ 85721 USA.
FU NCI NIH HHS [CA44355]
NR 45
TC 23
Z9 24
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0305-1048
EI 1362-4962
J9 NUCLEIC ACIDS RES
JI Nucleic Acids Res.
PD MAR 11
PY 1995
VL 23
IS 5
BP 869
EP 875
DI 10.1093/nar/23.5.869
PG 7
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QQ184
UT WOS:A1995QQ18400023
PM 7708505
ER
PT J
AU CURRAN, ME
SPLAWSKI, I
TIMOTHY, KW
VINCENT, GM
GREEN, ED
KEATING, MT
AF CURRAN, ME
SPLAWSKI, I
TIMOTHY, KW
VINCENT, GM
GREEN, ED
KEATING, MT
TI A MOLECULAR-BASIS FOR CARDIAC-ARRHYTHMIA - HERG MUTATIONS CAUSE LONG QT
SYNDROME
SO CELL
LA English
DT Article
ID EARLY AFTERDEPOLARIZATIONS; GENE; DNA; LINKAGE; IDENTIFICATION;
HETEROGENEITY; FRAGMENTS; CHANNEL; LOCUS; DEATH
AB To identify genes involved in cardiac arrhythmia, we investigated patients with long QT syndrome (LQT), an inherited disorder causing sudden death from a ventricular tachyarrhythmia, torsade de pointes. We previously mapped LQT loci on chromosomes 11 (LQT1), 7(LQT2), and 3(LQT3). Here, linkage and physical mapping place LQT2 and a putative potassium channel gene, HERG, on chromosome 7q35-36. Single strand conformation polymorphism and DNA sequence analyses reveal HERG mutations in six LQT families, including two intragenic deletions, one splice-donor mutation, and three missense mutations. In one kindred, the mutation arose de novo. Northern blot analyses show that HERG is strongly expressed in the heart. These data indicate that HERG is LQT2 and suggest a likely cellular mechanism for torsade de pointes.
C1 UNIV UTAH,HLTH SCI CTR,ECCLES PROGRAM HUMAN MOLEC BIOL & GENET,SALT LAKE CITY,UT 84112.
UNIV UTAH,HLTH SCI CTR,DIV CARDIOL,SALT LAKE CITY,UT 84112.
UNIV UTAH,HLTH SCI CTR,HOWARD HUGHES MED INST,SALT LAKE CITY,UT 84112.
LATTER DAY ST HOSP,DEPT MED,SALT LAKE CITY,UT 84037.
NIH,NATL CTR HUMAN GENOME RES,BETHESDA,MD 20892.
RP CURRAN, ME (reprint author), UNIV UTAH,HLTH SCI CTR,DEPT HUMAN GENET,SALT LAKE CITY,UT 84112, USA.
FU NCRR NIH HHS [MO1-RR00064]; NHLBI NIH HHS [R01-HL 48074]
NR 38
TC 1546
Z9 1589
U1 8
U2 68
PU CELL PRESS
PI CAMBRIDGE
PA 50 CHURCH ST CIRCULATION DEPT, CAMBRIDGE, MA 02138
SN 0092-8674
J9 CELL
JI Cell
PD MAR 10
PY 1995
VL 80
IS 5
BP 795
EP 803
DI 10.1016/0092-8674(95)90358-5
PG 9
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QM399
UT WOS:A1995QM39900016
PM 7889573
ER
PT J
AU ABRAMS, RM
BURCHFIELD, DJ
SUN, Y
SMITH, CB
AF ABRAMS, RM
BURCHFIELD, DJ
SUN, Y
SMITH, CB
TI PRENATAL DEVELOPMENT AND LOCAL-RATES OF CEREBRAL PROTEIN-SYNTHESIS
(ICPSLEU) IN SHEEP
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIMH,CEREBRAL METAB LAB,BETHESDA,MD 20892.
UNIV FLORIDA,COLL MED,DEPT OBSTET GYNECOL,GAINESVILLE,FL 32610.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A757
EP A757
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40600767
ER
PT J
AU AMICHAY, D
GAZZINELLI, R
KARUPIAH, G
MOENCH, T
SHER, A
FARBER, J
AF AMICHAY, D
GAZZINELLI, R
KARUPIAH, G
MOENCH, T
SHER, A
FARBER, J
TI MIG IS INDUCED IN THE MOUSE BY IFN-GAMMA AND BY PROTOZOAN AND
VIRAL-INFECTIONS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAID,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A783
EP A783
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40600916
ER
PT J
AU BARNES, DM
SYKES, DB
MILLER, DS
AF BARNES, DM
SYKES, DB
MILLER, DS
TI INSULIN-LIKE EFFECTS OF HGCL2 ON HEXOSE-TRANSPORT IN XENOPUS OOCYTES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS,RES TRIANGLE PK,NC 27709.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A635
EP A635
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40600061
ER
PT J
AU BIANCHINE, JP
PAOLINI, R
KINET, JP
METCALFE, DD
AF BIANCHINE, JP
PAOLINI, R
KINET, JP
METCALFE, DD
TI 3 DISTINCT PATHWAYS ACTIVATE FOCAL ADHESION KINASE IN MAST-CELLS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAID,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A781
EP A781
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40600901
ER
PT J
AU BOUCHER, W
PANG, X
WEBSTER, E
CHROUSOS, G
PAPANICOLAOU, D
THEOHARIDES, TC
AF BOUCHER, W
PANG, X
WEBSTER, E
CHROUSOS, G
PAPANICOLAOU, D
THEOHARIDES, TC
TI CORTICOTROPIN-RELEASING HORMONE (CRH) INDUCES RAT MAST-CELL (MC)
SECRETION
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 TUFTS UNIV,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,BOSTON,MA.
NIH,PEDIAT ENDOCRINOL SECT,BETHESDA,MD.
NR 0
TC 2
Z9 2
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A919
EP A919
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40601713
ER
PT J
AU CHANG, AC
WADSWORTH, SA
HONG, MP
HALVORSON, MJ
OTTO, S
COLIGAN, JE
AF CHANG, AC
WADSWORTH, SA
HONG, MP
HALVORSON, MJ
OTTO, S
COLIGAN, JE
TI EXPRESSION OF A NOVEL INTEGRIN BETA(1) CHAIN EPITOPE AND ANTI-BETA(1)
ANTIBODY-MEDIATED ENHANCEMENT OF FIBRONECTIN-BINDING ARE DEPENDENT ON
THE STAGE OF T-CELL DIFFERENTIATION
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAID,LMS,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A814
EP A814
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40601100
ER
PT J
AU CHOUDHURY, BK
HOU, EW
LI, SSL
AF CHOUDHURY, BK
HOU, EW
LI, SSL
TI STRUCTURE AND EVOLUTION OF THE NEUROGENIC ENHANCER OF SPLIT GROUCHO AND
RELATED GENES FROM HUMAN, MOUSE AND XENOPUS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS,GENET MOLEC LAB,RES TRIANGLE PK,NC 27709.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A705
EP A705
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40600470
ER
PT J
AU CHUANG, RY
CHUANG, LF
KUNG, HF
YU, L
KILLAM, KF
AF CHUANG, RY
CHUANG, LF
KUNG, HF
YU, L
KILLAM, KF
TI OPIOID RECEPTOR GENE-EXPRESSION IN LYMPHOCYTES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 UNIV CALIF DAVIS,DAVIS,CA 95616.
NCI,FREDERICK,MD 21701.
INDIANA UNIV,SCH MED,INDIANAPOLIS,IN 46202.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A850
EP A850
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40601311
ER
PT J
AU CIPPITELLI, M
SICA, A
VIGGIANO, V
YE, J
GHOSH, P
BIRRER, MJ
YOUNG, HA
AF CIPPITELLI, M
SICA, A
VIGGIANO, V
YE, J
GHOSH, P
BIRRER, MJ
YOUNG, HA
TI NEGATIVE TRANSCRIPTIONAL REGULATION OF THE INTERFERON-GAMMA (IFN-GAMMA)
PROMOTOR BY GLUCOCORTICOIDS AND DOMINANT-NEGATIVE MUTANTS OF C-JUN
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,FREDERICK CANC RES & DEV CTR,PRI DYNCORP,BCDP,FREDERICK,MD 21702.
NCI,FREDERICK CANC RES & DEV CTR,BRMP,LEI,FREDERICK,MD 21702.
NCI,DCPC,BPRB,ROCKVILLE,MD 20850.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A823
EP A823
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40601149
ER
PT J
AU COLE, DJ
WEIL, DP
SHILYANSKY, J
CUSTER, M
KAWAKAMI, Y
YANNELLI, J
ROSENBERG, SA
NISHIMURA, MI
AF COLE, DJ
WEIL, DP
SHILYANSKY, J
CUSTER, M
KAWAKAMI, Y
YANNELLI, J
ROSENBERG, SA
NISHIMURA, MI
TI T-CELL RECEPTOR USAGE AND EPITOPE MAPPING OF HLA-A2 RESTRICTED, MELANOMA
REACTIVE CTL CLONES AND OLIGOCLONAL LINES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 MED UNIV S CAROLINA,DEPT SURG,CHARLESTON,SC 29425.
NCI,SURG BRANCH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A801
EP A801
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40601018
ER
PT J
AU DEBRE, P
RUSCETTI, FW
MOSSALAYI, J
AF DEBRE, P
RUSCETTI, FW
MOSSALAYI, J
TI EARLY HUMAN THYMOCYTES DEVELOPMENT IS REGULATED BY AN EXTERNALLY
CONTROLLED AUTOCRINE TGF-BETA(1) MECHANISM
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 HOP LA PITIE SALPETRIERE,IMMUNOL LAB,PARIS,FRANCE.
NCI,LEUKOCYTE BIOL LAB,FREDERICK,MD 21701.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A815
EP A815
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40601101
ER
PT J
AU FRAZIERJESSEN, M
CHRIST, M
PANEK, RB
MCCARTNEYFRANCIS, N
KATONA, I
BAUER, S
KULKARNI, A
WARD, J
WAHL, S
AF FRAZIERJESSEN, M
CHRIST, M
PANEK, RB
MCCARTNEYFRANCIS, N
KATONA, I
BAUER, S
KULKARNI, A
WARD, J
WAHL, S
TI ABERRANT B-LYMPHOCYTE FUNCTION IN TGF-BETA-1(-/-) NULL MICE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDR,BETHESDA,MD 20892.
NINCDS,BETHESDA,MD 20892.
NCI,BETHESDA,MD 20892.
NIH,BETHESDA,MD 20892.
US FDA,BETHESDA,MD 20892.
UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814.
NR 0
TC 3
Z9 3
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A814
EP A814
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40601095
ER
PT J
AU FRENCH, JE
NYLANDERFRENCH, LA
AF FRENCH, JE
NYLANDERFRENCH, LA
TI SYNERGISTIC IN-VITRO CYTOTOXICITY OF UVA RADIATION AND CHEMICAL
ELECTROPHILES TO NORMAL HUMAN SKIN CELLS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 SNIOH,S-17184 SOLNA,SWEDEN.
NIEHS,RES TRIANGLE PK,NC 27709.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A713
EP A713
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40600512
ER
PT J
AU FUNAKOSHI, S
TAUB, DD
ANVER, MR
WEEKS, SD
RAZIUDDIN, A
CORRALES, SM
ARMITAGE, RJ
FANSLOW, WC
LONGO, DL
MURPHY, WJ
AF FUNAKOSHI, S
TAUB, DD
ANVER, MR
WEEKS, SD
RAZIUDDIN, A
CORRALES, SM
ARMITAGE, RJ
FANSLOW, WC
LONGO, DL
MURPHY, WJ
TI TREATMENT OF MICE WITH SOLUBLE RECOMBINANT CD40 LIGAND PROMOTES B-CELL
RECOVERY AFTER SYNGENEIC BONE-MARROW TRANSPLANTATION
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,FREDERICK CANC RES & DEV CTR,DCT,LLB,FREDERICK,MD 21702.
NCI,FREDERICK CANC RES & DEV CTR,PRI DYNCORP,BCDP,FREDERICK,MD 21702.
NCI,FREDERICK CANC RES & DEV CTR,PRI DYNCORP,LASP,FREDERICK,MD 21702.
IMMUNEX CORP,SEATTLE,WA 98101.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A783
EP A783
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40600917
ER
PT J
AU GALLAGHER, D
VISSER, M
HARRIS, TB
HEYMSFIELD, SB
AF GALLAGHER, D
VISSER, M
HARRIS, TB
HEYMSFIELD, SB
TI PROPORTION OF FAT-FREE BODY-MASS AS SKELETAL-MUSCLE MASS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 ST LUKES ROOSEVELT HOSP,OBES RES CTR,NEW YORK,NY 10025.
AGR UNIV WAGENINGEN,DEPT HUMAN NUTR,WAGENINGEN,NETHERLANDS.
NIA,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A979
EP A979
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40602062
ER
PT J
AU HAMAWY, MM
MINOGUCHI, K
SWAIM, WD
MERGENHAGEN, SE
SIRAGANIAN, RP
AF HAMAWY, MM
MINOGUCHI, K
SWAIM, WD
MERGENHAGEN, SE
SIRAGANIAN, RP
TI A 77 KDA PROTEIN ASSOCIATES WITH PP125(FAK) IN MAST-CELLS BUT NOT IN
FIBROBLASTS AND BECOMES PHOSPHORYLATED ON TYROSINE AFTER AGGREGATION OF
THE HIGH-AFFINITY IGE RECEPTOR
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDR,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A781
EP A781
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40600904
ER
PT J
AU HAMELINK, CR
ESKAY, RL
CASTONGUAY, TW
AF HAMELINK, CR
ESKAY, RL
CASTONGUAY, TW
TI ACCESS TO A FAT SUPPLEMENT STIMULATES HYPOTHALAMIC-PITUITARY-ADRENAL
(HPA) AXIS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAAA,BETHESDA,MD.
UNIV MARYLAND,COLLEGE PK,MD.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A1005
EP A1005
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40602207
ER
PT J
AU HARRISON, EH
KEMPNER, ES
AF HARRISON, EH
KEMPNER, ES
TI SIZE OF THE CATALYTICALLY ACTIVE UNIT OF RAT HEPATIC CARBOXYLESTER
LIPASE (CEL) IN THE PRESENCE AND ABSENCE OF BILE-SALT
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAMSD,BETHESDA,MD.
MED COLL PENN,PHILADELPHIA,PA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A747
EP A747
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40600711
ER
PT J
AU HEEMSKERK, FMJ
GALOIAN, KA
SAAVEDRA, JM
AF HEEMSKERK, FMJ
GALOIAN, KA
SAAVEDRA, JM
TI CHARACTERIZATION AND SOLUBILIZATION OF A NOVEL RECEPTOR FOR CGP-42112 IN
THE RAT SPLEEN
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIMH,CLIN SCI LAB,PHARMACOL SECT,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A925
EP A925
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40601752
ER
PT J
AU HERION, D
RYSCHON, T
ROSENSTEIN, D
ELIN, R
NIEMELA, J
RUBINOW, D
ECKARDT, M
BALABAN, R
AF HERION, D
RYSCHON, T
ROSENSTEIN, D
ELIN, R
NIEMELA, J
RUBINOW, D
ECKARDT, M
BALABAN, R
TI TISSUE MAGNESIUM CONCENTRATIONS IN ALCOHOLICS AND CONTROLS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,BETHESDA,MD 20892.
NIAAA,BETHESDA,MD 20892.
NIMH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A870
EP A870
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40601430
ER
PT J
AU HORNUNG, RL
LONGO, DL
KWAK, LW
AF HORNUNG, RL
LONGO, DL
KWAK, LW
TI T-CELL MEDIATION OF ANTIGEN-SPECIFIC IMMUNE BONE-MARROW THERAPY AGAINST
AN ESTABLISHED LYMPHOMA
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,FREDERICK CANC RES & DEV CTR,PRI DYNCORP,BCDP,FREDERICK,MD 21702.
NCI,FREDERICK CANC RES & DEV CTR,BIOL RESPONSE MODIFIERS PROGRAM,FREDERICK,MD 21702.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A799
EP A799
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40601011
ER
PT J
AU KARANIAN, J
SALEM, N
AF KARANIAN, J
SALEM, N
TI HYDROPEROXY AND HYDROXY N-3/N-6 FATTY-ACIDS IN PLATELET AND VASCULAR
SMOOTH-MUSCLE FUNCTION - INTERFERENCE WITH TXA2/PGH2 RECEPTORS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAAA,DICBR,MEMBRANE BIOCHEM & BIOPHYS LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A939
EP A939
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40601830
ER
PT J
AU KING, LB
HUNZIKER, R
MARGULIES, DH
ASHWELL, JD
AF KING, LB
HUNZIKER, R
MARGULIES, DH
ASHWELL, JD
TI A TARGETED GLUCOCORTICOID RECEPTOR ANTISENSE TRANSGENE ENHANCES
APOPTOTIC THYMOCYTE DELETION
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,BIOL RESPONSE MODIFIERS PROGRAM,IMMUNE CELL BIOL LAB,BETHESDA,MD 20892.
NIAID,IMMUNOL LAB,BETHESDA,MD 20892.
RI Margulies, David/H-7089-2013
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A778
EP A778
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40600888
ER
PT J
AU KLEINMAN, HK
AF KLEINMAN, HK
TI ROLE OF BASEMENT-MEMBRANE IN DIFFERENTIATION AND TUMORS GROWTH
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDR,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A695
EP A695
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40600409
ER
PT J
AU KOLE, HK
SMYTH, MS
RUSS, PL
BURKE, TR
AF KOLE, HK
SMYTH, MS
RUSS, PL
BURKE, TR
TI PHOSPHONATE-CONTAINING INHIBITORS OF PROTEIN-TYROSINE AND SERINE
THREONINE PHOSPHATASES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIA,GERONTOL RES CTR,DIABET UNIT,BALTIMORE,MD 21224.
NCI,DIV CANC TREATMENT,DEV THERAPEUT PROGRAM,BETHESDA,MD 20892.
NCI,MED CHEM LAB,BETHESDA,MD 20892.
NIA,CLIN PHYSIOL LAB,BALTIMORE,MD 21224.
RI Burke, Terrence/N-2601-2014
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A752
EP A752
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40600741
ER
PT J
AU KWON, TK
BUCHHOLZ, M
GABRIELSON, E
NORDIN, A
AF KWON, TK
BUCHHOLZ, M
GABRIELSON, E
NORDIN, A
TI A NOVEL SUBSTRATE FOUND IN EPITHELIAL TYPE CELLS FOR CDK4 AND CDK6
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIA,GERONTOL RES CTR,BALTIMORE,MD 21224.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A1066
EP A1066
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40602557
ER
PT J
AU LIU, K
ROMAN, JS
KAMALI, V
NAUGHTON, BA
KELLER, J
RUSCETTI, FW
ROODMAN, D
BONEWALD, L
MEAGHER, RM
PURCHIO, AF
TWARDZIK, DR
AF LIU, K
ROMAN, JS
KAMALI, V
NAUGHTON, BA
KELLER, J
RUSCETTI, FW
ROODMAN, D
BONEWALD, L
MEAGHER, RM
PURCHIO, AF
TWARDZIK, DR
TI STEM-CELL PROLIFERATION FACTOR (SCPF) INDUCES THE EXPANSION OF PRIMITIVE
CD34 CELLS IN CULTURE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 ADV TISSUE SCI INC,LA JOLLA,CA 92037.
NCI,FREDERICK,MD 21702.
HOXWORTH BLOOD CTR,CINCINNATI,OH 45267.
UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78284.
AUDIE L MURPHY MEM VET ADM MED CTR,SAN ANTONIO,TX 78284.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A940
EP A940
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40601840
ER
PT J
AU LONGMAN, RE
REMMERS, EF
DU, Y
GRIFFITHS, M
WILDER, RL
AF LONGMAN, RE
REMMERS, EF
DU, Y
GRIFFITHS, M
WILDER, RL
TI GENETIC-LOCI CONTROLLING COLLAGEN-INDUCED ARTHRITIS (CIA) SEVERITY IN
PROGENY OF DA (SUSCEPTIBLE) AND F344 (RESISTANT) RAT STRAINS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 VET AFFAIRS MED CTR,RES SERV,SALT LAKE CITY,UT 84132.
UNIV UTAH,DEPT MED RHEUMATOL,SALT LAKE CITY,UT 84132.
NIH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A786
EP A786
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40600932
ER
PT J
AU MELILLO, G
MUSSO, T
COX, GW
SICA, A
SHEFFLER, LA
VARESIO, L
AF MELILLO, G
MUSSO, T
COX, GW
SICA, A
SHEFFLER, LA
VARESIO, L
TI IDENTIFICATION OF A FUNCTIONAL PICOLINIC ACID-RESPONSE ELEMENT IN THE
PROMOTER OF INDUCIBLE NITRIC-OXIDE SYNTHASE (INOS) GENE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,FREDERICK CANC RES & DEV CTR,BIOL RESPONSE MODIFIERS PROGRAM,EXPTL IMMUNOL LAB,FREDERICK,MD 21702.
NCI,FREDERICK CANC RES & DEV CTR,PRI DYNCORP,BCDP,FREDERICK,MD 21702.
RI varesio, luigi/J-8261-2016
OI varesio, luigi/0000-0001-5659-2218
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A779
EP A779
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40600890
ER
PT J
AU MILLER, DS
VILLALOBOS, AR
PRITCHARD, JB
AF MILLER, DS
VILLALOBOS, AR
PRITCHARD, JB
TI ORGANIC-BASE (QUINACRINE, QCRN) UPTAKE AND DISTRIBUTION IN RAT
CHOROID-PLEXUS CELLS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS,CELLULAR & MOLEC PHARMACOL LAB,RES TRIANGLE PK,NC 27709.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A915
EP A915
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40601694
ER
PT J
AU MULLET, D
BIAN, X
COX, GW
ZAVERI, N
GERBER, N
FERTEL, RH
AF MULLET, D
BIAN, X
COX, GW
ZAVERI, N
GERBER, N
FERTEL, RH
TI GALLIUM NITRATE INHIBITS NITRIC-OXIDE PRODUCTION BY ACTIVATED ANA-1
MACROPHAGES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 OHIO STATE UNIV,COLL MED,DEPT PHARMACOL,COLUMBUS,OH 43210.
PUMC,DEPT OBSTET & GYNECOL,BEIJING,PEOPLES R CHINA.
NCI,FREDERICK CANC RES & DEV CTR,BIOL RESPONSE MODIFIERS PROGRAM,EXPTL IMMUNOL LAB,FREDERICK,MD 21702.
NR 0
TC 2
Z9 2
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A944
EP A944
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40601860
ER
PT J
AU MUNOZ, K
BALLARDBARBASH, R
SWANSON, C
AF MUNOZ, K
BALLARDBARBASH, R
SWANSON, C
TI RECALL OF BODY-WEIGHT AND BODY-SIZE ESTIMATION IN WOMEN IN THE
BREAST-CANCER DEMONSTRATION PROJECT (BCDDP)
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A1013
EP A1013
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40602255
ER
PT J
AU OELTGEN, PR
HORTON, ND
KAFTANI, DJ
SU, TP
AF OELTGEN, PR
HORTON, ND
KAFTANI, DJ
SU, TP
TI BIOCHEMICAL-CHARACTERIZATION OF A HIBERNATION-SPECIFIC PROTEIN FROM THE
PLASMA OF HIBERNATING WOODCHUCKS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDA,BALTIMORE,MD 21224.
VET ADM MED CTR,LEXINGTON,KY 40511.
UNIV KENTUCKY,COLL MED,GRAD CTR TOXICOL,DEPT PATHOL,LEXINGTON,KY 40511.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A642
EP A642
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40600106
ER
PT J
AU OHANLON, TP
RABEN, N
MILLER, FW
AF OHANLON, TP
RABEN, N
MILLER, FW
TI THE HUMAN HISTIDYL-TRANSFER-RNA SYNTHETASE LOCUS BIDIRECTIONAL PROMOTER
DIRECTS THE SYNTHESIS OPPOSITE-STRAND MESSENGER-RNA THAT PREDICTS A
POLYPEPTIDE HOMOLOGOUS WITH HRS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 US FDA,CTR BIOL EVALUAT & RES,BETHESDA,MD 20892.
NIAMS,BETHESDA,MD 20892.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A857
EP A857
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40601349
ER
PT J
AU ORTALDO, JR
MASON, AT
OSHEA, JJ
AF ORTALDO, JR
MASON, AT
OSHEA, JJ
TI RECEPTOR-INDUCED DEATH IN HUMAN NK CELLS - INVOLVEMENT OF CD16
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,FREDERICK CANC RES & DEV CTR,BIOL RESPONSE MODIFIERS PROGRAM,LEI,FREDERICK,MD 21702.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A793
EP A793
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40600975
ER
PT J
AU PANEK, RB
BRANDES, ME
WAHL, SM
AF PANEK, RB
BRANDES, ME
WAHL, SM
TI CYTOKINE REGULATION OF TGF-BETA RECEPTOR EXPRESSION IN PERIPHERAL-BLOOD
MONOCYTES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDR,IMMUNOL LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A1021
EP A1021
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40602301
ER
PT J
AU PARK, CS
GIANOTTI, C
PARK, R
KRISHNA, G
AF PARK, CS
GIANOTTI, C
PARK, R
KRISHNA, G
TI MOLECULAR-CLONING AND EXPRESSION OF CONSTITUTIVE ISOFORM OF NITRIC-OXIDE
SYNTHASE FROM HUMAN RETINA
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A680
EP A680
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40600324
ER
PT J
AU PINET, V
BAKKE, O
LONG, EO
AF PINET, V
BAKKE, O
LONG, EO
TI ANTIGEN PRESENTATION MEDIATED BY RECYCLING OF SURFACE HLA-DR MOLECULES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAID,IMMUNOGENET LAB,ROCKVILLE,MD 20852.
UNIV OSLO,DEPT BIOL,OSLO,NORWAY.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A1026
EP A1026
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40602327
ER
PT J
AU PRITCHARD, JB
AF PRITCHARD, JB
TI IMPACT OF INTRACELLULAR ALPHA-KETOGLUTARATE (ALPHA-KG) CONCENTRATION AND
COMPARTMENTATION ON RENAL ORGANIC ANION TRANSPORT
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS,CELLULAR & MOLEC PHARMACOL LAB,RES TRIANGLE PK,NC 27709.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A915
EP A915
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40601692
ER
PT J
AU ROUBENOFF, R
KIEL, DP
HANNAN, MT
DALLAL, GE
WILSON, PWF
HARRIS, TB
AF ROUBENOFF, R
KIEL, DP
HANNAN, MT
DALLAL, GE
WILSON, PWF
HARRIS, TB
TI VALIDATION OF BIOELECTRICAL-IMPEDANCE (BIA) IN AN AMBULATORY ELDERLY
POPULATION
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 TUFTS UNIV,HUMAN NUTR RES CTR AGING,JMUSDA,BOSTON,MA 02111.
HEBREW REHABIL CTR AGED,RES INST,BOSTON,MA 02131.
BOSTON UNIV,SCH MED,BOSTON,MA 02118.
FRAMINLGHAM HEART STUDY,FRAMINGHAM,MA 01701.
NIA,EDBP,BETHESDA,MD 20892.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A980
EP A980
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40602069
ER
PT J
AU SCHNAPER, HW
KOPP, JB
TOBAR, A
KLEINMAN, HK
AF SCHNAPER, HW
KOPP, JB
TOBAR, A
KLEINMAN, HK
TI ASSUMPTION OF A MATRIX-ACCUMULATING PHENOTYPE BY HUMAN GLOMERULAR
MESANGIAL CELLS SUBJECTED TO SERIAL PASSAGE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDR,BETHESDA,MD.
NORTHWESTERN UNIV,SCH MED,CHICAGO,IL.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A696
EP A696
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40600416
ER
PT J
AU SEKALY, RP
THIBODEAU, J
CROTEAU, G
LABRECQUE, N
ARONSON, HE
CANTIN, C
LONG, EO
FLEURY, S
AF SEKALY, RP
THIBODEAU, J
CROTEAU, G
LABRECQUE, N
ARONSON, HE
CANTIN, C
LONG, EO
FLEURY, S
TI HLA-DR POLYMORPHISM AFFECTS THE INTERACTION WITH CD4
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 INST RECH CLIN MONTREAL,IMMUNOL LAB,MONTREAL,PQ,CANADA.
UNIV MONTREAL,DEPT MICROBIOL & IMMUNOL,MONTREAL,PQ,CANADA.
COLUMBIA UNIV,DEPT BIOCHEM & MOLEC BIOPHYS,NEW YORK,NY 10027.
NIAID,BETHESDA,MD.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A1055
EP A1055
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40602495
ER
PT J
AU SHANKARAPPA, B
NICHOLAS, HB
GUPTA, P
RINALDO, CR
GORRY, MC
NARA, PL
EHRLICH, GD
AF SHANKARAPPA, B
NICHOLAS, HB
GUPTA, P
RINALDO, CR
GORRY, MC
NARA, PL
EHRLICH, GD
TI GENOTYPIC CLUSTERING OF THE INFECTING QUASI-SPECIES AND INCREASED
VARIABILITY AT LATER TIME POINTS ARE ASSOCIATED WITH A MORE RAPID
DECLINE OF CD4+ CELL NUMBERS IN HIV-1 INFECTION
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,FREDERICK,MD 21701.
UNIV PITTSBURGH,PITTSBURGH,PA 15261.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A1052
EP A1052
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40602476
ER
PT J
AU SHEFFLER, LA
WINK, DA
MELILLO, G
COX, GW
AF SHEFFLER, LA
WINK, DA
MELILLO, G
COX, GW
TI EXOGENOUS NITRIC-OXIDE (NO) REGULATES INTERFERON-GAMMA PLUS
LIPOPOLYSACCHARIDE-INDUCED NO SYNTHASE EXPRESSION IN MOUSE MACROPHAGES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,FREDERICK CANC RES & DEV CTR,BIOL RESPONSE MODIFIERS PROGRAM,EXPTL IMMUNOL LAB,FREDERICK,MD 21702.
NCI,FREDERICK CANC RES & DEV CTR,COMPARAT CARCINOGENESIS LAB,FREDERICK,MD 21702.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A1039
EP A1039
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40602399
ER
PT J
AU SHOAF, SE
SCHMALL, B
AF SHOAF, SE
SCHMALL, B
TI DEVELOPMENT OF ALPHA-METHYL-L-TRYPTOPHAN (ALPHA-MTP) AS A TRACER OF
BRAIN-SEROTONIN SYNTHESIS IN RHESUS-MONKEY
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAAA,BETHESDA,MD 20892.
NIH,CTR CLIN,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A688
EP A688
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40600373
ER
PT J
AU SILVER, J
AKOLKAR, PN
GULWANIAKOLKAR, B
ROBINSON, MA
AF SILVER, J
AKOLKAR, PN
GULWANIAKOLKAR, B
ROBINSON, MA
TI INFLUENCE OF NON-HLA GENES ON THE TCR REPERTOIRE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAID,ROCKVILLE,MD.
N SHORE UNIV HOSP,CORNELL UNIV MED COLL,MANHASSET,NY 11030.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A817
EP A817
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40601113
ER
PT J
AU STENGEL, PW
RIPPY, MK
COCKERHAM, SL
DEVANE, WA
SILBAUGH, SA
AF STENGEL, PW
RIPPY, MK
COCKERHAM, SL
DEVANE, WA
SILBAUGH, SA
TI ANTIINFLAMMATORY AND BRONCHODILATOR ACTIONS OF ANANDAMIDE, A PUTATIVE
CANNABINOID RECEPTOR AGONIST, IN GUINEA-PIGS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 ELI LILLY & CO,INDIANAPOLIS,IN 46285.
NIMH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A718
EP A718
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40600540
ER
PT J
AU STUBER, E
NEURATH, M
CALDERHEAD, D
FELL, P
STROBER, W
AF STUBER, E
NEURATH, M
CALDERHEAD, D
FELL, P
STROBER, W
TI THE OX40-OX40L INTERACTION - A NOVEL PATHWAY IN T-CELL-DEPENDENT B-CELL
ACTIVATION
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAID,CLIN INVEST LAB,MUCOSAL IMMUN SECT,BETHESDA,MD 20892.
BRISTOL MYERS SQUIBB PHARMACEUT RES INST,DEPT MOLEC IMMUNOL,SEATTLE,WA 98121.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A771
EP A771
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40600847
ER
PT J
AU SWIETER, M
BERENSTEIN, EH
SIRAGANIAN, RP
AF SWIETER, M
BERENSTEIN, EH
SIRAGANIAN, RP
TI PROTEIN-TYROSINE-PHOSPHATASE COPRECIPITATES WITH THE HIGH-AFFINITY IGE
RECEPTOR AND DEPHOSPHORYLATES THE RECEPTOR SUBUNITS BUT NOT LYN OR SYK
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDR,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A781
EP A781
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40600903
ER
PT J
AU TOMASI, M
KISSIN, E
MCCARTNEYFRANCIS, N
WAHL, SM
SMITH, PD
AF TOMASI, M
KISSIN, E
MCCARTNEYFRANCIS, N
WAHL, SM
SMITH, PD
TI AGE-RELATED DECLINE IN MACROPHAGE PRODUCTION OF NITRIC-OXIDE (NO)
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 UNIV ALABAMA,SCH MED,BIRMINGHAM,AL 35294.
NIH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A1039
EP A1039
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40602402
ER
PT J
AU VILLALOBOS, AR
PARMELEE, JT
PRITCHARD, JB
AF VILLALOBOS, AR
PARMELEE, JT
PRITCHARD, JB
TI TETRAETHYLAMMONIUM (TEA) TRANSPORT BY PRIMARY CULTURES OF RAT
CHOROID-PLEXUS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS,CELLULAR & MOLEC PHARMACOL LAB,RES TRIANGLE PK,NC 27709.
MANCHESTER COMMUNITY TECH COLL,MANCHESTER,CT 06045.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A915
EP A915
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40601695
ER
PT J
AU VISSER, M
GALLAGHER, D
HARRIS, TB
HEYMSFIELD, SB
AF VISSER, M
GALLAGHER, D
HARRIS, TB
HEYMSFIELD, SB
TI DIFFERENCES IN APPENDICULAR SKELETAL-MUSCLE MASS BETWEEN BLACK-AND-WHITE
SUBJECTS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 AGR UNIV WAGENINGEN,DEPT HUMAN NUTR,WAGENINGEN,NETHERLANDS.
ST LUKES ROOSEVELT HOSP,OBES RES CTR,NEW YORK,NY 10025.
NIA,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A980
EP A980
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40602066
ER
PT J
AU WANG, J
HARGROVE, ME
TING, CC
AF WANG, J
HARGROVE, ME
TING, CC
TI DIFFERENTIAL REGULATION BY IL-4 OF PROTEIN-TYROSINE PHOSPHORYLATION IN
IL-2-INDUCED LAK CELLS AND ALPHA-CD3-INDUCED CD3-AK CELLS AND THE
CORRELATION WITH THEIR CYTOLYTIC ACTIVITY
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A823
EP A823
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40601153
ER
PT J
AU WASHBURN, BS
TULLIS, K
BADEN, DG
REIN, K
WALSH, PJ
HINTON, DE
DENISON, MS
AF WASHBURN, BS
TULLIS, K
BADEN, DG
REIN, K
WALSH, PJ
HINTON, DE
DENISON, MS
TI MECHANISM OF INDUCTION OF CYTOCHROME P4501A BY BREVETOXIN (PBTX), A
POLYETHER MARINE NEUROTOXIN
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 UNIV CALIF DAVIS,DAVIS,CA 95616.
UNIV MIAMI,ROSENSTIEL SCH MARINE & ATMOSPHER SCI,NIEHS,CTR MARINE & FRESHWATER BIOMED SCI,MIAMI,FL 33149.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A714
EP A714
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40600517
ER
PT J
AU WITONSKY, S
FOSTER, C
BOWEN, J
NEILSEN, N
SOMMARDAHL, C
SIEBENLIST, U
WOYCHIK, RP
WILKINSON, JE
AF WITONSKY, S
FOSTER, C
BOWEN, J
NEILSEN, N
SOMMARDAHL, C
SIEBENLIST, U
WOYCHIK, RP
WILKINSON, JE
TI PATHOBIOLOGY OF NF-KB TRANSGENIC MICE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 UNIV TENNESSEE,COLL VET MED,KNOXVILLE,TN 37901.
OAK RIDGE NATL LAB,DIV BIOL,OAK RIDGE,TN 37831.
NIH,BETHESDA,MD 20814.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A721
EP A721
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40600558
ER
PT J
AU ZHU, Q
ZHANG, M
BLASE, RM
DERRY, JMJ
CHEN, SH
FRANCKE, U
OCHS, HD
AF ZHU, Q
ZHANG, M
BLASE, RM
DERRY, JMJ
CHEN, SH
FRANCKE, U
OCHS, HD
TI MUTATION ANALYSIS OF THE WISKOTT-ALDRICH SYNDROME GENE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 UNIV WASHINGTON,SCH MED,SEATTLE,WA 98195.
NIH,BETHESDA,MD 20892.
STANFORD UNIV,HOWARD HUGHES MED INST,STANFORD,CA 94305.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 10
PY 1995
VL 9
IS 4
BP A780
EP A780
PN 2
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QM406
UT WOS:A1995QM40600896
ER
PT J
AU KIM, HY
KLAUSNER, RD
ROUAULT, TA
AF KIM, HY
KLAUSNER, RD
ROUAULT, TA
TI TRANSLATIONAL REPRESSOR ACTIVITY IS EQUIVALENT AND IS QUANTITATIVELY
PREDICTED BY IN-VITRO RNA-BINDING FOR 2 IRON-RESPONSIVE ELEMENT-BINDING
PROTEINS, IRP1 AND IRP2
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Note
ID FERRITIN MESSENGER-RNA; PURIFICATION; REGION
AB Iron regulatory proteins (IRPs) bind to specific RNA stem-loop structures known as iron-responsive elements (IREs) which mediate the post-transcriptional regulation of many genes of iron metabolism. Most studies have focused on the role of IRP1, which has previously been shown to bind with high affinity to IREs and mediate repression of in vitro translation of ferritin mRNAs. More recently, a second IRP has been identified that is expressed in all tissues and that binds IREs (Rouault, T. A., Haile, D. H., Downey, W. E., Philpott, C. C., Tang, C., Samaniego, F., Chin, J., Paul, I., Orloff, D., Harford, J. B., and Klausner, R. D. (1992) BioMetals 5, 131-140; Henderson, B. R., Seiser, C., and Kuhn, L. C. (1993) J. Biol. Chem. 268, 27327-27334; Guo, B., Yu, Y., and Leibold, E. A. (1994) J. Biol. Chem. 269, 24252-24260; Samaniego, F., Chin, J., Iwai, K., Rouault, T. A., and Klausner, R. D. (1994) J. Biol. Chem. 269, 30904-30910). Here we report that purified recombinant IRP2 inhibits translation of ferritin mRNAs with a molar efficacy equal to that of recombinant IRP1. There is a quantitative correlation between binding to isolated RNA target motifs, as judged by gel retardation assays, and translational repressor function as assayed in an in vitro translation system. In contrast to IRP1, IRP2 is not inactivated for RNA binding by alkylation with N-ethylmaleimide or phenylmaleimide, and as we would therefore predict, IRP2 treated with N-ethyhmaleimide remains an effective repressor of ferritin translation. As IRP1 and IRP2 clearly have equal capability of mediating translational repression in vitro, the contributions of both IRPs to overall regulation must be considered in describing the pathways of iron regulated gene expression in individual cells.
RP KIM, HY (reprint author), NICHHD,CELL BIOL & METAB BRANCH,BETHESDA,MD 20892, USA.
NR 24
TC 74
Z9 73
U1 0
U2 0
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 10
PY 1995
VL 270
IS 10
BP 4983
EP 4986
PG 4
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QL580
UT WOS:A1995QL58000008
PM 7890603
ER
PT J
AU KOLEY, AP
BUTERS, JTM
ROBINSON, RC
MARKOWITZ, A
FRIEDMAN, FK
AF KOLEY, AP
BUTERS, JTM
ROBINSON, RC
MARKOWITZ, A
FRIEDMAN, FK
TI CO BINDING-KINETICS OF HUMAN CYTOCHROME-P450 3A4 - SPECIFIC INTERACTION
OF SUBSTRATES WITH KINETICALLY DISTINGUISHABLE CONFORMERS
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID HUMAN-LIVER; MICROSOMAL CYTOCHROME-P-450; DRUG-METABOLISM; ENZYME;
IDENTIFICATION; PURIFICATION; OXIDATION; PROTEIN; ACID
AB The kinetics of CO binding to human cytochrome P450 3A4 was examined by the flash photolysis technique, employing the membrane-bound P450 expressed in baculovirus-infected SF9 insect cells, Triexponential kinetics was observed, indicating that P450 3A4 is composed of multiple, kinetically distinguishable conformers. To define the substrate specificity of individual P450 3A4 conformers we evaluated the effect of a series of substrates of varying sizes and structures on the CO binding kinetics. The rate of CO binding to the total mixture of P450 3A4 conformers was increased in the presence of nifedipine and erythromycin, decreased by quinidine, testosterone, and warfarin, and unaffected by cimetidine and 17 alpha-ethynylestradiol. A recently developed kinetic difference method (Koley, A. P., Robinson, R. C., Markowitz, A., and Friedman, F. K. (1994) Biochemistry 33, 2484-2489) was used to define the kinetic parameters of individual P450 3A4 conformers. The results showed that different conformers have distinct substrate specificities. The substrates had markedly variable effects on the CO binding kinetics of their target P450 3A4 conformers and thus differentially modulate their conformations. These results demonstrate that the interaction of a particular substrate with a specific P450 3A4 conformer can be assessed in the presence of multiple conformers.
C1 NCI,MOLEC CARCINOGENESIS LAB,BETHESDA,MD 20892.
NIH,BIOMED ENGN & INSTRUMENTAT PROGRAM,BETHESDA,MD 20892.
RI Buters, Jeroen/G-5070-2011; Friedman, Fred/D-4208-2016
NR 24
TC 83
Z9 83
U1 0
U2 0
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 10
PY 1995
VL 270
IS 10
BP 5014
EP 5018
PG 5
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QL580
UT WOS:A1995QL58000013
PM 7890608
ER
PT J
AU BEITNERJOHNSON, D
LEROITH, D
AF BEITNERJOHNSON, D
LEROITH, D
TI INSULIN-LIKE GROWTH-FACTOR-I STIMULATES TYROSINE PHOSPHORYLATION OF
ENDOGENOUS C-CRK
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID PHOSPHATIDYLINOSITOL 3'-KINASE; RECEPTOR SUBSTRATE-1; PROTEINS; CELLS;
IRS-1; SH2; ASSOCIATION; BINDING; GENE; GRB2
AB Crk, a cellular homolog of v-crk, is an SH2 and SH3 domain-containing adaptor protein related to Grb2 and Nck, two proteins which have been shown to be involved in growth factor signal transduction. Crk proteins have recently been found to associate with two guanine nucleotide releasing proteins, mSos and C3G, and thus appear to lie on the Ras pathway. We investigated whether Crk is a target for the insulin-like growth factor I (IGF-I) receptor tyrosine kinase. We show that IGF-I stimulates tyrosine phosphorylation of Crk II via stimulation of endogenous IGF-I receptors in both 293 cells and NIH-3T3 cells. IGF-I stimulated tyrosine phosphorylation of Crk II in a dose- and time-dependent manner. In 293 cells, which express both IGF-I and insulin receptors, insulin also induced a dose dependent tyrosine phosphorylation of Crk II, but with somewhat reduced sensitivity, compared to IGF-I. In NIH 3T3 cells, IGF-I also stimulated tyrosine phosphorylation of a 45- kDa protein which co immunoprecipitated with Crk II. These findings indicate that Crk II is an endogenous substrate of the IGF-I receptor tyrosine kinase and provide the first demonstration that a mitogenic growth factor induces tyrosine phosphorylation of endogenous c-Crk.
RP BEITNERJOHNSON, D (reprint author), NIDDK,DIABET BRANCH,BLDG 10,RM 8S-239,10 CTR DR,MSC 1770,BETHESDA,MD 20892, USA.
NR 33
TC 99
Z9 100
U1 0
U2 0
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 10
PY 1995
VL 270
IS 10
BP 5187
EP 5190
PG 4
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QL580
UT WOS:A1995QL58000037
PM 7534289
ER
PT J
AU SCHMIDT, HHJ
REMALEY, AT
STONIK, JA
RONAN, R
WELLMANN, A
THOMAS, F
ZECH, LA
BREWER, HB
HOEG, JM
AF SCHMIDT, HHJ
REMALEY, AT
STONIK, JA
RONAN, R
WELLMANN, A
THOMAS, F
ZECH, LA
BREWER, HB
HOEG, JM
TI CARBOXYL-TERMINAL DOMAIN TRUNCATION ALTERS APOLIPOPROTEIN-A-I IN-VIVO
CATABOLISM
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID HIGH-DENSITY-LIPOPROTEINS; LECITHIN-CHOLESTEROL ACYLTRANSFERASE;
CORONARY HEART-DISEASE; INVIVO METABOLISM; EXCHANGEABLE APOLIPOPROTEINS;
AMPHIPATHIC HELIX; APOA-I; PLASMA; DEGRADATION; CONVERSION
AB Apolipoprotein A-I (apoA-I), the major protein of high density lipoproteins, facilitates reverse cholesterol transport from peripheral tissue to liver. To determine the structural motifs important for modulating the in vivo catabolism of human apoA-I (h-apoA-I), we generated carboxyl-terminal truncation mutants at residues 201 (apoA-I-201), 217 (apoA-I-217), and 226 (apoA-I-226) by site directed mutagenesis. ApoA-I was expressed in Escherichia coli as a fusion protein with the maltose binding protein, which was removed by factor Xa cleavage. The in vivo kinetic analysis of the radioiodinated apoA-I in normolipemic rabbits revealed a markedly increased rate of catabolism for the truncated forms of apoA-I. The fractional catabolic rates (FCR) of 9.10 +/- 1.28/day (+/-S.D.) for apoA-I-201, 6.34 +/- 0.81/day for apoA-I-217, and 4.42 +/- 0.51/day for apoA-I-226 were much faster than the FCR of recombinant intact apoA-I (r-apoA-I, 0.93 +/- 0.07/day) and h-apoA-I (0.91 +/- 0.34/day), All the truncated forms of apoA-I were associated with very high density lipoproteins, whereas the intact recombinant apoA-I (r-apoA-I) and h-apoA-I associated with HDL(2) and HDL(3), Gel filtration chromatography revealed that in contrast to r-apoA-I, the mutant apoA-I-201 associated with a phospholipid-rich rabbit apoA-I containing particle. Analysis by agarose gel electrophoresis demonstrated that the same mutant migrated in the pre-beta position, but not within the alpha position as did r-apoA-I. These results indicate that the carboxyl-terminal region (residue 227-243) of apoA-I is critical in modulating the association of apoA-I with lipoproteins and in vivo metabolism of apoA-I.
C1 NHLBI, CELL BIOL SECT, MOLEC DIS BRANCH, BETHESDA, MD 20892 USA.
NR 75
TC 60
Z9 61
U1 0
U2 0
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0021-9258
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 10
PY 1995
VL 270
IS 10
BP 5469
EP 5475
PG 7
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QL580
UT WOS:A1995QL58000079
PM 7890663
ER
PT J
AU WHITEHURST, CE
OWAKI, H
BRUDER, JT
RAPP, UR
GEPPERT, TD
AF WHITEHURST, CE
OWAKI, H
BRUDER, JT
RAPP, UR
GEPPERT, TD
TI THE MEK KINASE-ACTIVITY OF THE CATALYTIC DOMAIN OF RAF-1 IS REGULATED
INDEPENDENTLY OF RAS BINDING IN T-CELLS
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID ACTIVATED PROTEIN-KINASE; MAP KINASE; SIGNAL TRANSDUCTION; THREONINE
KINASE; TYROSINE PHOSPHORYLATION; SERINE PHOSPHORYLATION; TRANSCRIPTION
FACTOR; BIOLOGICAL-ACTIVITY; RECEPTOR; INHIBITION
AB Deletion of the amino-terminal domain of Raf-1, which contains the Ras-binding region, results in the constitutive activation of the liberated Raf-1 catalytic domain in fibroblast cell lines. We demonstrate that the MEK kinase activity of the isolated Raf-1 catalytic domain, Raf-BXB, is not constitutively active, but is regulated in Jurkat T cells. Raf-BXB is activated by engaging the antigen receptor-CD3 complex, or treating cells with phorbol myristate acetate or okadaic acid. Increasing intracellular cAMP inhibits Raf-1 activation stimulated by phorbol myristate acetate, but not the activation of Raf-BXB. Serine 621, but not serine 499, is essential for Raf-BXB MEK kinase activity. Because Raf-BXB does not bind Ras, the data establishes a Ras-independent signal in directly regulating the activity of the Raf-1 catalytic domain.
C1 UNIV TEXAS,SW MED CTR,DEPT INTERNAL MED,DALLAS,TX 75235.
UNIV TEXAS,SW MED CTR,GRAD PROGRAM IMMUNOL,DALLAS,TX 75235.
NCI,FREDERICK CANC RES & DEV CTR,VIRAL CARCINOGENESIS LAB,FREDERICK,MD 21702.
NR 65
TC 53
Z9 53
U1 0
U2 0
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 10
PY 1995
VL 270
IS 10
BP 5594
EP 5599
PG 6
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QL580
UT WOS:A1995QL58000096
PM 7534298
ER
PT J
AU COSO, OA
CHIARIELLO, R
KALINEC, G
KYRIAKIS, JM
WOODGETT, J
GUTKIND, JS
AF COSO, OA
CHIARIELLO, R
KALINEC, G
KYRIAKIS, JM
WOODGETT, J
GUTKIND, JS
TI TRANSFORMING G-PROTEIN-COUPLED RECEPTORS POTENTLY ACTIVATE JNK (SAPK) -
EVIDENCE FOR A DIVERGENCE FROM THE TYROSINE KINASE SIGNALING PATHWAY
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID GENES; JUN; PHOSPHORYLATION; TRANSDUCTION; RAS
AB The expression of human muscarinic acetylcholine receptors (mAChRs) in NIH 3T3 cells has been used as a model for studying proliferative signaling through G protein-coupled receptors. In this biological system, the mi class of mAChRs can effectively transduce mitogenic signals (Stephens, E. V., Kalinec, G., Brann, M. R., and Gutkind, J. S. (1993) Oncogene 8, 19-26) and induce malignant transformation if persistently activated (Gutkind, J. S., Novotny, E. A., Brann, M. R., and Robbins, K. C. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 4703-4708). Moreover, available evidence suggests that the mi-signaling pathway converges at the level of p21(ras) with that emerging from tyrosine kinase receptors (Crespo, P., Xu, N., Simonds, W. F., and Gutkind, J. S. (1994) Nature 369, 418-420). To explore nuclear events involved in growth regulation by G protein-coupled receptors in this setting, we compared the effect of platelet-derived growth factor (PDGF) and the cholinerse agonist, carbachol, on the expression of mRNA for members of the jun and fos family of nuclear proto-oncogenes. We found that activation of m1 receptors by carbachol induces the expression of a distinct set of nuclear transcription factors. In particular, carbachol caused a much greater induction of c-jun mRNA and AP-1 activity. These responses did not correlate with protein kinase C stimulation nor with the activation of mitogen-activated protein (MAP) kinases. Recently, it has been shown that a novel family of kinases structurally related to MAP kinases, stress-activated protein kinases, or Jun kinases (JNKs), phospho rylate in vivo the amino-terminal transactivating domain of the c-Jun protein, thereby increasing its transcriptional activity. In view of our results, this observation prompted us to ask whether m1 and PDGF can differentially activate JNKs. Here, we show that m1 mAChRs can induce a remarkable increase in JNK activity, which was temporally distinct from that of MAP kinase and was entirely protein kinase C independent. In contrast, PDGF failed to activate JNK in these cells, although it stimulated MAP kinase to an extent even greater than that for carbachol. These findings demonstrate that G protein-coupled receptors can signal through pathways leading to the activation of JNK, thus diverging at this level with those signaling routes utilized by tyrosine kinase receptors.
C1 NIDR,CELLULAR DEV & ONCOL LAB,MOLEC SIGNALING UNIT,BETHESDA,MD 20892.
HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DIABET UNIT,BOSTON,MA 02129.
PRINCESS MARGARET HOSP,ONTARIO CANC INST,TORONTO,ON M4X 1K9,CANADA.
RI Gutkind, J. Silvio/A-1053-2009; Woodgett, Jim/F-1087-2010; Chiariello,
Mario/O-3642-2014
OI Woodgett, Jim/0000-0003-3731-5797; Chiariello, Mario/0000-0001-8434-5177
NR 28
TC 211
Z9 212
U1 0
U2 2
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 10
PY 1995
VL 270
IS 10
BP 5620
EP 5624
PG 5
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA QL580
UT WOS:A1995QL58000100
PM 7890682
ER
PT J
AU CASSELL, DJ
SCHWARTZ, RH
AF CASSELL, DJ
SCHWARTZ, RH
TI A COMPARISON OF B-CELL AND DENDRITIC CELL ANTIGEN PRESENTATION TO NAIVE
T-CELLS
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIAID,CELLULAR & MOLEC IMMUNOL LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 4
EP 4
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400007
ER
PT J
AU GERMAIN, RN
CASTELLINO, F
ROMAGNOLI, P
MADRENAS, J
WANGE, R
ISAKOV, N
SAMELSON, LE
AF GERMAIN, RN
CASTELLINO, F
ROMAGNOLI, P
MADRENAS, J
WANGE, R
ISAKOV, N
SAMELSON, LE
TI FORMATION AND FUNCTION OF PEPTIDE - MHC MOLECULE LIGANDS FOR THE TCR
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIAID,IMMUNOL LAB,LYMPHOCYTE BIOL SECT,BETHESDA,MD 20892.
NICHHD,CELL BIOL & METAB BRANCH,BETHESDA,MD 20892.
RI Romagnoli, Paola/K-2237-2014
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 4
EP 4
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400006
ER
PT J
AU WEISSMAN, D
ANANWORANICH, J
BARKER, TD
DAUCHER, JA
LI, YX
ORENSTEIN, JM
FAUCI, AS
AF WEISSMAN, D
ANANWORANICH, J
BARKER, TD
DAUCHER, JA
LI, YX
ORENSTEIN, JM
FAUCI, AS
TI ROLE OF DENDRITIC CELLS IN THE IMMUNOPATHOGENESIS OF HIV DISEASE
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIAID,IMMUNOREGULAT LAB,BETHESDA,MD 20892.
GEORGE WASHINGTON UNIV,MED CTR,WASHINGTON,DC 20037.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 8
EP 8
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400018
ER
PT J
AU JANIK, JE
MILLER, LL
KOPP, W
GAUSE, B
CURTI, B
LONGO, DL
AF JANIK, JE
MILLER, LL
KOPP, W
GAUSE, B
CURTI, B
LONGO, DL
TI A PHASE-I TRIAL OF TUMOR-NECROSIS-FACTOR (TNF) AND
GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR (GM-CSF) TO ENHANCE
DENDRITIC CELL MATURATION
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NCI,BIOL RESPONSE MODIFIERS PROGRAM,FREDERICK,MD 21701.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 11
EP 11
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400032
ER
PT J
AU SCHWARZENBERGER, K
UDEY, MC
AF SCHWARZENBERGER, K
UDEY, MC
TI MODULATION OF LANGERHANS CELL E-CADHERIN EXPRESSION DURING THE
INITIATION PHASE OF CONTACT SENSITIVITY REACTIONS
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NCI,DERMATOL BRANCH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 14
EP 14
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400042
ER
PT J
AU MAURER, D
EBNER, C
REININGER, B
FIEBIGER, E
KRAFT, D
KINET, JP
STINGL, G
AF MAURER, D
EBNER, C
REININGER, B
FIEBIGER, E
KRAFT, D
KINET, JP
STINGL, G
TI FC-EPSILON-RI MEDIATES IGE-DEPENDENT ALLERGEN PRESENTATION
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 UNIV VIENNA,SCH MED,DIAID,A-1010 VIENNA,AUSTRIA.
NIAID,MOL ALL & IMMUNOL SECT,ROCKVILLE,MD.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 21
EP 21
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400067
ER
PT J
AU RIDGE, JP
FUCHS, E
MATZINGER, P
AF RIDGE, JP
FUCHS, E
MATZINGER, P
TI NEONATAL TOLERANCE IS A NUMBERS GAME
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIH,CELLULAR & MOLEC IMMUNOL LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 21
EP 21
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400068
ER
PT J
AU LONG, EO
BAKKE, O
PINET, V
AF LONG, EO
BAKKE, O
PINET, V
TI ANTIGEN PRESENTATION MEDIATED BY RECYCLING OF SURFACE HLA-DR MOLECULES
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIAID,IMMUNOGENT LAB,ROCKVILLE,MD 20852.
UNIV OSLO,DEPT BIOL,OSLO 3,NORWAY.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 28
EP 28
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400096
ER
PT J
AU RIVERO, JL
IENDOUBI, M
AF RIVERO, JL
IENDOUBI, M
TI INVARIANT CHAIN KNOCKOUT MICE A TOOL TO STUDY AUTOIMMUNE-DISEASES
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NEI,GENET & IMMUNOL SECT,IMMUNOL LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 31
EP 31
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400106
ER
PT J
AU BLAUVELT, A
CHOUGNET, C
SHEARER, GM
KATZ, SI
AF BLAUVELT, A
CHOUGNET, C
SHEARER, GM
KATZ, SI
TI PROTEIN ANTIGEN PRESENTATION BY EPIDERMAL LANGERHANS CELLS IN
NORMAL-APPEARING SKIN OF INDIVIDUALS WITH AIDS IS NORMAL
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NCI,DERMATOL BRANCH,BETHESDA,MD 20892.
NCI,EXPTL IMMUNOL BRANCH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 33
EP 33
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400114
ER
PT J
AU ESPEY, MG
TANG, Y
MORSE, HC
MOFFETT, JR
ARYAN, MA
AF ESPEY, MG
TANG, Y
MORSE, HC
MOFFETT, JR
ARYAN, MA
TI DENDRITIC CELLS, QUINOLINIC ACID, AND THE MURINE MODEL OF AIDS
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 GEORGETOWN UNIV,DEPT BIOL,WASHINGTON,DC 20057.
NIAID,IMMUNOPATHOL LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 33
EP 33
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400117
ER
PT J
AU MANN, DL
KASLOW, RA
APPLE, R
CARRINGTON, M
MUNOZ, A
PARK, L
DETELS, R
RINALDO, C
PHAIR, J
GEODERT, J
SAAH, A
AF MANN, DL
KASLOW, RA
APPLE, R
CARRINGTON, M
MUNOZ, A
PARK, L
DETELS, R
RINALDO, C
PHAIR, J
GEODERT, J
SAAH, A
TI HLA CLASS-I, CLASS-II, AND TAP GENES STRONGLY INFLUENCE THE COURSE OF
HIV-INFECTION
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIH,FREDERICK,MD 21702.
RI apple, raymond/I-4506-2012
OI apple, raymond/0000-0002-8007-0345
NR 0
TC 0
Z9 0
U1 0
U2 2
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 34
EP 34
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400119
ER
PT J
AU SHER, A
AF SHER, A
TI LESSONS FROM PARASITES ON THE INITIATION AND REGULATION OF CELLULAR
IMMUNE FUNCTION
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIAID,PARASIT DIS LAB,IMMUNOBIOL SECT,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 56
EP 56
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400180
ER
PT J
AU CLERICI, M
SARIN, A
LUCEY, DR
PINTO, LA
WYNN, TA
BLATT, SP
HENDRIX, CW
DOLAN, MJ
WOLF, SF
BERZOFSKY, JA
HENKART, PA
SHEARER, GM
AF CLERICI, M
SARIN, A
LUCEY, DR
PINTO, LA
WYNN, TA
BLATT, SP
HENDRIX, CW
DOLAN, MJ
WOLF, SF
BERZOFSKY, JA
HENKART, PA
SHEARER, GM
TI MODIFICATION OF THE IMMUNE-RESPONSE IN HIV-INFECTION BY TYPE-1 TYPE-2
CYTOKINE REGULATION
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 GENET INST INC,CAMBRIDGE,MA.
UNIV MILAN,I-20122 MILAN,ITALY.
NCI,BETHESDA,MD 20892.
NIAID,BETHESDA,MD 20892.
WILFORD HALL USAF MED CTR,LACKLAND AFB,TX 78236.
RI Wynn, Thomas/C-2797-2011; Hendrix, Craig/G-4182-2014
OI Hendrix, Craig/0000-0002-5696-8665
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 60
EP 60
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400193
ER
PT J
AU COMBADIERE, B
FREEDMAN, M
LENARDO, MJ
AF COMBADIERE, B
FREEDMAN, M
LENARDO, MJ
TI DISTINCT T-CELL RECEPTOR SIGNALING PATHWAYS CONTROL LYMPHOKINE INDUCTION
AND PROGRAMMED CELL-DEATH IN MATURE T-LYMPHOCYTES
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIAID,IMMUNOL LAB,BETHESDA,MD 20892.
RI Combadiere, Behazine/G-3881-2013
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 66
EP 66
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400214
ER
PT J
AU KIM, YH
BUCHHOLZ, MA
NORDIN, AA
AF KIM, YH
BUCHHOLZ, MA
NORDIN, AA
TI A NEW ASPECT OF IL-2 R SIGNALING PATHWAY IN MURINE T-LYMPHOCYTES
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 KYUNGPOOK NATL UNIV,COLL NAT SCI,DEPT MICROBIOL,TAEGU 702701,SOUTH KOREA.
NIA,GERONTOL RES CTR,CLIN IMMUNOL SECT,BALTIMORE,MD 21224.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 74
EP 74
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400246
ER
PT J
AU LENCZOWSKI, JM
ZACHARCHUK, CM
BIRRER, M
ASHWELL, JD
AF LENCZOWSKI, JM
ZACHARCHUK, CM
BIRRER, M
ASHWELL, JD
TI THE EXPRESSION OF A DOMINANT-NEGATIVE CJUN ALTERS INDUCTION OF AP-1
COMPONENTS IN T-CELL LINES
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NCI,LICB,BETHESDA,MD 20892.
NIH,HHMI,RES SCHOLARS PROGRAM,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 76
EP 76
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400252
ER
PT J
AU KENNY, JJ
FISCHER, RT
REED, JC
LONGO, DL
AF KENNY, JJ
FISCHER, RT
REED, JC
LONGO, DL
TI BCL-2 PREVENTS THE CLONAL DELETION OF PHOSPHOCHOLINE-SPECIFIC B-CELLS IN
MU-KAPPA BUT NOT IN MU-ONLY M167 TRANSGENIC XID MICE
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 LA JOLLA CANC RES FDN,LA JOLLA,CA 92037.
NCI,FCRDC,BIOL RESPONSE MODIFIERS PROGRAM,FREDERICK,MD 21702.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 98
EP 98
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400342
ER
PT J
AU LOBANOFF, MC
LAI, JC
FUKUSHIMA, A
WAWROUSEK, EF
LEE, RS
WHITCUP, SM
SMITHGILL, SJ
AF LOBANOFF, MC
LAI, JC
FUKUSHIMA, A
WAWROUSEK, EF
LEE, RS
WHITCUP, SM
SMITHGILL, SJ
TI IMMUNOTOLERANCE IN TRANSGENIC MICE EXPRESSING A FOREIGN ANTIGEN IN A
SEQUESTERED ORGAN
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NEI,BETHESDA,MD 20892.
HOWARD HUGHES MED INST,BETHESDA,MD.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 101
EP 101
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400352
ER
PT J
AU LONG, EO
BAKKE, O
PINET, V
AF LONG, EO
BAKKE, O
PINET, V
TI ANTIGEN PRESENTATION MEDIATED BY RECYCLING OF SURFACE HLA-DR MOLECULES
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIAID,IMMUNOGENET LAB,BETHESDA,MD 20892.
UNIV OSLO,DEPT BIOL,OSLO 3,NORWAY.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 101
EP 101
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400354
ER
PT J
AU BENDELAC, A
AF BENDELAC, A
TI THE LIGAND OF MOUSE NK1.1+T-CELLS
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIH,BETHESDA,MD 20892.
PRINCETON UNIV,PRINCETON,NJ 08544.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 112
EP 112
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400396
ER
PT J
AU FISHER, GH
ZUNIGAPFLUCKER, JC
LENARDO, M
AF FISHER, GH
ZUNIGAPFLUCKER, JC
LENARDO, M
TI TCR CROSS-LINKING IS SUFFICIENT FOR ACTIVATION BUT NOT DELETION OF
DOUBLE-POSITIVE THYMOCYTES
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIAID,BETHESDA,MD 20814.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 117
EP 117
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400417
ER
PT J
AU GIESE, T
DAVIDSON, WF
AF GIESE, T
DAVIDSON, WF
TI CD8+ T-CELLS ARE THE PREDOMINANT SOURCE OF B220+ DOUBLE-NEGATIVE T-CELLS
IN LPR AND GLD MICE
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NCI,GENET LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 118
EP 118
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400421
ER
PT J
AU KHATTRI, R
QIAN, DP
LOVE, PE
FITCH, FW
BLUESTONE, JA
AF KHATTRI, R
QIAN, DP
LOVE, PE
FITCH, FW
BLUESTONE, JA
TI T-CELL RECEPTOR GAMMA-DELTA-CELL DEVELOPMENT AND FUNCTION IN
ZETA-DEFICIENT MICE
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 UNIV CHICAGO,BEN MAY INST,CHICAGO,IL 60637.
UNIV CALIF SAN FRANCISCO,DEPT MED,SAN FRANCISCO,CA 94143.
UNIV CALIF SAN FRANCISCO,HOWARD HUGHES MED INST,SAN FRANCISCO,CA 94143.
NICHHD,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 122
EP 122
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400434
ER
PT J
AU SOMMERS, CL
HUANG, K
GRINBERG, A
LOVE, PE
AF SOMMERS, CL
HUANG, K
GRINBERG, A
LOVE, PE
TI CLONING OF MURINE TXK - A PROTEIN-TYROSINE KINASE EXPRESSED EARLY IN
FETAL THYMIC DEVELOPMENT
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NICHHD,MAMMALIAN GENES & DEV LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 130
EP 130
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400466
ER
PT J
AU VACCHIO, MS
ASHWELL, JD
AF VACCHIO, MS
ASHWELL, JD
TI INFLUENCE OF THYMIC-DERIVED STEROIDS ON POSITIVE SELECTION OF THYMOCYTES
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 US FDA,CBER,DIV HEMATOL PROD,BETHESDA,MD 20892.
NCI,IMMUNE CELL BIOL LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 132
EP 132
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400473
ER
PT J
AU ALEXANDERMILLER, MA
PARKER, KC
TSUKUI, T
PENDLETON, D
COLIGAN, JE
BERZOFSKY, JA
AF ALEXANDERMILLER, MA
PARKER, KC
TSUKUI, T
PENDLETON, D
COLIGAN, JE
BERZOFSKY, JA
TI P18-SPECIFIC, HLA-A2 RESTRICTED AND H-2D(I) RESTRICTED CTL SHARE A
COMMON MINIMAL EPITOPE WHICH UTILIZED SIMILAR RESIDUES FOR MHC BINDING
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NCI,METAB BRANCH,BETHESDA,MD 20892.
NIAID,MOLEC STRUCT LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 135
EP 135
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400485
ER
PT J
AU BERZOFSKY, JA
TAKESHITA, T
TAKAHASHI, H
KOZLOWSKI, S
AHLERS, JD
PENDLETON, CD
MOORE, RL
NAKAGAWA, Y
YOKOMURO, K
FOX, BS
MARGULIES, DH
AF BERZOFSKY, JA
TAKESHITA, T
TAKAHASHI, H
KOZLOWSKI, S
AHLERS, JD
PENDLETON, CD
MOORE, RL
NAKAGAWA, Y
YOKOMURO, K
FOX, BS
MARGULIES, DH
TI MOLECULAR-BASIS OF FUNCTIONAL BINDING OF THE SAME HIV PEPTIDE TO BOTH A
CLASS-I AND A CLASS-II MHC MOLECULE
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIAID,IMMUNOL LAB,BETHESDA,MD 20892.
NCI,METAB BRANCH,BETHESDA,MD 20892.
UNIV MARYLAND,SCH MED,DEPT MED,BALTIMORE,MD 21201.
NIPPON MED COLL,DEPT MICROBIOL & IMMUNOL,TOKYO 113,JAPAN.
RI Margulies, David/H-7089-2013
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 135
EP 135
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400488
ER
PT J
AU CLERICI, M
PINTO, L
SHEARER, GM
AF CLERICI, M
PINTO, L
SHEARER, GM
TI EVIDENCE FOR IMMUNE PROTECTION TO HIV
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 UNIV MILAN,CATTEDRA IMMUNOL,I-20133 MILAN,ITALY.
NCI,EXPTL IMMUNOL BRANCH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 138
EP 138
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400498
ER
PT J
AU DAVIDSON, WF
GIESE, T
AF DAVIDSON, WF
GIESE, T
TI EVIDENCE FOR AGE-RELATED ABNORMALITIES IN THE DELETION OF ACTIVATED
PERIPHERAL T-CELLS IN IPR AND GLD MICE
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NCI,GENET LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 139
EP 139
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400501
ER
PT J
AU DOHERTY, TM
GIESE, N
MORSE, HC
COFFMAN, RL
AF DOHERTY, TM
GIESE, N
MORSE, HC
COFFMAN, RL
TI THE ROLE OF CYTOKINES IN A MURINE MODEL OF ACQUIRED
IMMUNOLOGICAL-UNRESPONSIVENESS
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 DNAX INC,CELLULAR & MOLEC BIOL RES INST,PALO ALTO,CA 94304.
NIAID,IMMUNOPATHOL LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 140
EP 140
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400505
ER
PT J
AU GUO, WX
BURGER, A
FISCHER, RT
LONGO, DL
KENNY, JJ
AF GUO, WX
BURGER, A
FISCHER, RT
LONGO, DL
KENNY, JJ
TI ANALYSIS OF T15-IDIOTYPE NEGATIVE ANTI-PHOSPHOCHOLINE ANTIBODIES FROM
X-LINKED IMMUNE-DEFICIENT XID, MICE
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NCI,FCRDC,PRI DYNCORP,FREDERICK,MD 21702.
BIOL RESPONSE MODIFIERS PROGRAM,FREDERICK,MD 21702.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 142
EP 142
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400515
ER
PT J
AU MARSHALL, MA
ACTOR, JK
SHER, A
BERZOFSKY, JA
AF MARSHALL, MA
ACTOR, JK
SHER, A
BERZOFSKY, JA
TI SUPPRESSION OF HIV-SPECIFIC CTL RESPONSE BY LYMPHOCYTES FROM
HELMINTH-INFECTED MICE
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NCI,METAB BRANCH,BETHESDA,MD 20892.
NIAID,PARASIT DIS LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 148
EP 148
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400537
ER
PT J
AU MORAWETZ, R
GIESE, N
MORSE, HC
AF MORAWETZ, R
GIESE, N
MORSE, HC
TI RELATIONSHIPS OF CYTOKINE EXPRESSION AND CELL SIGNALING TO PATHOGENESIS
OF MAIDS, A RETROVIRUS-INDUCED IMMUNODEFICIENCY SYNDROME OF MICE
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIAID,IMMUNOPATHOL LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 149
EP 149
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400543
ER
PT J
AU CIERNIK, IF
YANUCK, M
BERZOFSKY, JA
CARBONE, DP
AF CIERNIK, IF
YANUCK, M
BERZOFSKY, JA
CARBONE, DP
TI EXPRESSION OF A MUTANT P53 EPITOPE FUSED WITH THE ADENOVIRUS E3 LEADER
SEQUENCE IN TUMOR-CELLS OVERCOMES GAMMA-IFN DEPENDENCE OF LYSIS BY
P53-SPECIFIC CTL
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 UNIV TEXAS,HLTH SCI CTR,SW MED SCH,SIMMONS CANC CTR,DALLAS,TX 75235.
NCI,METAB BRANCH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 163
EP 163
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400596
ER
PT J
AU HATHCOCK, KS
PUCILLO, CEM
LASZLO, G
LAI, L
HODES, RJ
AF HATHCOCK, KS
PUCILLO, CEM
LASZLO, G
LAI, L
HODES, RJ
TI ANALYSIS OF NOVEL THYMIC SUBPOPULATIONS EXPRESSING THE CELL-SURFACE
MOLECULE GL7 - EXPRESSION, GENETICS, AND FUNCTION
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NCI,EIB,BETHESDA,MD 20892.
NIA,BETHESDA,MD 20892.
PHARMINGEN,SAN DIEGO,CA 92121.
RI Pucillo, Carlo/A-5515-2008
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 168
EP 168
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400616
ER
PT J
AU STEVENSON, MM
TAM, MF
SHER, A
AF STEVENSON, MM
TAM, MF
SHER, A
TI INTERLEUKIN-12 INDUCES A PROTECTIVE TH1 RESPONSE IN PLASMODIUM-CHABAUDI
AS SUSCEPTIBLE A/J MICE
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 MONTREAL GEN HOSP,RES INST,CTR STUDY HOST RESISTANCE,MONTREAL,PQ H3G 1A4,CANADA.
NIAID,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 178
EP 178
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400655
ER
PT J
AU SADEGHNASSERI, S
MARGULIES, D
STERN, L
GREEN, D
AF SADEGHNASSERI, S
MARGULIES, D
STERN, L
GREEN, D
TI FORMATION OF SPECIFIC LOW-AFFINITY PEPTIDE CLASS-II DOES NOT REQUIRE
PEPTIDE SIDE-CHAIN INTERACTIONS WITH CLASS-II GROOVE
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 AMER RED CROSS,DEPT IMMUNOL,ROCKVILLE,MD 20855.
NIAID,BETHESDA,MD 20892.
MIT,DEPT CHEM,CAMBRIDGE,MA 02139.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 181
EP 181
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400668
ER
PT J
AU WYNN, TA
JANKOVIC, D
POINDEXTER, R
CASPAR, P
CHEEVER, A
SHER, A
AF WYNN, TA
JANKOVIC, D
POINDEXTER, R
CASPAR, P
CHEEVER, A
SHER, A
TI VACCINATION WITH PARASITE (EGG) ANTIGEN PLUS IL-12 SWITCHES
HELMINTH-INDUCED CYTOKINE RESPONSES FROM A TH2 TO A TH1 PATTERN AND
BLOCKS PATHOLOGY
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIH,PARASIT DIS LAB,BETHESDA,MD 20892.
RI Wynn, Thomas/C-2797-2011
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 182
EP 182
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400673
ER
PT J
AU BIESSMANN, H
MASON, JM
AF BIESSMANN, H
MASON, JM
TI DNA ORGANIZATION OF DIPTERAN TELOMERES AND THEIR ELONGATION BY SPECIFIC
RETROTRANSPOSONS
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 UNIV CALIF IRVINE,CTR DEV BIOL,IRVINE,CA 92717.
NIEHS,RES TRIANGLE PK,NC 27709.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 186
EP 186
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400679
ER
PT J
AU VERNICK, K
AF VERNICK, K
TI MOLECULAR ASPECTS OF PLASMODIUM RESISTANCE IN ANOPHELES-GAMBIAE
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 189
EP 189
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400689
ER
PT J
AU BARREAU, C
TOURAY, M
MILLER, L
VERNICK, K
AF BARREAU, C
TOURAY, M
MILLER, L
VERNICK, K
TI IDENTIFICATION OF SURFACE MOLECULES OF MOSQUITO SALIVARY-GLANDS WHICH
MALARIA SPOROZOITES USE AS RECEPTORS FOR INVASION
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 205
EP 205
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400741
ER
PT J
AU SARAIVA, EMB
MIALHE, EL
SHAHABUDDIN, M
VERNICK, K
MILLER, LH
AF SARAIVA, EMB
MIALHE, EL
SHAHABUDDIN, M
VERNICK, K
MILLER, LH
TI RESEARCH FOR GENETIC-TRANSFORMATION OF DIPTERA VECTORS
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIAID,MALARIA RES LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 226
EP 226
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400825
ER
PT J
AU STORZ, G
ALTUVIA, S
TOLEDANO, MB
KULLIK, I
AF STORZ, G
ALTUVIA, S
TOLEDANO, MB
KULLIK, I
TI THE OXYR REGULON
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NICHHD,CELL BIOL & METAB BRANCH,BETHESDA,MD 20892.
NR 2
TC 0
Z9 0
U1 1
U2 1
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 236
EP 236
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400851
ER
PT J
AU TOLEDANO, MB
KULLIK, I
STORZ, G
AF TOLEDANO, MB
KULLIK, I
STORZ, G
TI REDOX-DEPENDENT SHIFT OF OXYR-DNA CONTACTS ALONG AN EXTENDED DNA-BINDING
SITE - A MECHANISM FOR DIFFERENTIAL PROMOTER SELECTION
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 UMDNJ,RUTGERS COLL PHARM,DEPT PHARMACOL & TOXICOL,PISCATAWAY,NJ 08855.
NICHHD,CELL BIOL & METAB BRANCH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 3
U2 6
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 247
EP 247
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400888
ER
PT J
AU YAMAGUCHIIWAI, Y
YUAN, DS
DANCIS, A
KLAUSNER, RD
AF YAMAGUCHIIWAI, Y
YUAN, DS
DANCIS, A
KLAUSNER, RD
TI AFT1 - ACTIVATOR OF FERROUS TRANSPORT REGULATES IRON UPTAKE
TRANSCRIPTIONALLY IN SACCHAROMYCES-CEREVISIAE
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NICHHD,CELL BIOL & METAB BRANCH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 251
EP 251
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400905
ER
PT J
AU SUNDARESAN, M
YU, ZX
IRANI, K
FINKEL, T
AF SUNDARESAN, M
YU, ZX
IRANI, K
FINKEL, T
TI THE ROLE OF HYDROGEN-PEROXIDE IN GROWTH-FACTOR SIGNALING
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NHLBI,CARDIOL BRANCH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 256
EP 256
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400924
ER
PT J
AU WOLFFE, AP
ALMOUZNI, G
BOUVET, P
DIMITROV, S
HAYES, JJ
LANDSBERGER, N
NIGHTINGLAE, K
PRUSS, D
URA, K
AF WOLFFE, AP
ALMOUZNI, G
BOUVET, P
DIMITROV, S
HAYES, JJ
LANDSBERGER, N
NIGHTINGLAE, K
PRUSS, D
URA, K
TI CHROMATIN STRUCTURE AND GENE-EXPRESSION
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
ID TRANSCRIPTION; ACETYLATION
C1 NICHHD,MOLEC EMBRYOL LAB,BETHESDA,MD 20892.
RI dimitrov, stefan/M-7697-2013
NR 10
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 270
EP 270
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400963
ER
PT J
AU KUNKEL, TA
THOMAS, DC
BOYER, JC
MINNICK, DT
IZUTA, S
ROBERTS, JD
UMAR, A
YIN, S
NGUYEN, DC
AF KUNKEL, TA
THOMAS, DC
BOYER, JC
MINNICK, DT
IZUTA, S
ROBERTS, JD
UMAR, A
YIN, S
NGUYEN, DC
TI STUDIES OF DNA-REPLICATION FIDELITY IN HUMAN CELL-EXTRACTS
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIEHS,MOLEC GENET LAB,RES TRIANGLE PK,NC 27709.
NR 13
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 271
EP 271
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400964
ER
PT J
AU WANG, XW
EGLY, JM
WANG, Z
FRIEDBERG, EC
EVANS, MK
BOHR, VA
HOEIJMAKERS, JHJ
HARRIS, CC
AF WANG, XW
EGLY, JM
WANG, Z
FRIEDBERG, EC
EVANS, MK
BOHR, VA
HOEIJMAKERS, JHJ
HARRIS, CC
TI P53 DNA-REPAIR AND CARCINOGENESIS
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NCI,HUMAN CARCINOGENESIS LAB,BETHESDA,MD 20892.
FAC MED STRASBOURG,INSERM,CNRS,UPR 6520,F-67000 STRASBOURG,FRANCE.
NIA,MOLEC GENET LAB,BALTIMORE,MD 21224.
UNIV TEXAS SW MED CTR,DEPT PATHOL,DALLAS,TX 75235.
ERASMUS UNIV ROTTERDAM,CTR MED GENET,DEPT CELL BIOL & GENET,3000 DR ROTTERDAM,NETHERLANDS.
RI Wang, Xin/B-6162-2009
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 272
EP 272
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400969
ER
PT J
AU SANDER, M
HUANG, SM
GU, LY
AF SANDER, M
HUANG, SM
GU, LY
TI SINGLE AMINO-ACID CHANGES ALTER THE REPAIR SPECIFICITY OF DROSOPHILA
RRP1 - ISOLATION OF MUTANTS DEFICIENT IN REPAIR OF OXIDATIVE DAMAGE
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIEHS,MOLEC GENET LAB,RES TRIANGLE PK,NC 27709.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 276
EP 276
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86400982
ER
PT J
AU WANG, XW
YEH, H
SCHAEFFER, L
ROY, R
MONCOLLIN, V
EGLY, JM
WANG, Z
FRIEDBERG, EC
EVANS, MK
TAFFE, BG
BOHR, VA
WEEDA, G
HOEIJMAKERS, JHJ
FORRESTER, K
HARRIS, CC
AF WANG, XW
YEH, H
SCHAEFFER, L
ROY, R
MONCOLLIN, V
EGLY, JM
WANG, Z
FRIEDBERG, EC
EVANS, MK
TAFFE, BG
BOHR, VA
WEEDA, G
HOEIJMAKERS, JHJ
FORRESTER, K
HARRIS, CC
TI P53 MODULATION OF BTF2-TFIIH ASSOCIATED NUCLEOTIDE EXCISION-REPAIR
ACTIVITY
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NCI,HUMAN CARCINOGENESIS LAB,BETHESDA,MD 20892.
FAC MED STRASBOURG,INSERM,UNITE 184,CNRS,UPR 6520,F-67085 STRASBOURG,FRANCE.
NIA,MOLEC GENET LAB,BALTIMORE,MD 21224.
ERASMUS UNIV ROTTERDAM,CTR MED GENET,DEPT CELL BIOL & GENET,3000 DR ROTTERDAM,NETHERLANDS.
UNIV TEXAS,SW MED CTR,DEPT PATHOL,MOLEC PATHOL LAB,DALLAS,TX 75235.
RI Wang, Xin/B-6162-2009
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 281
EP 281
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401000
ER
PT J
AU OTRIN, VR
TAKAO, M
MCLENIGAN, M
LEVINE, AS
PROTIC, M
AF OTRIN, VR
TAKAO, M
MCLENIGAN, M
LEVINE, AS
PROTIC, M
TI EXPRESSION AND REGULATION OF THE UV-DAMAGED DNA-BINDING PROTEIN XP-E
FACTOR
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NICHHD,DNA REPLICAT REPAIR & MUTAGENESIS SECT,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 284
EP 284
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401014
ER
PT J
AU OKINAKA, RT
PEREZ, A
LAUBSCHER, K
SENA, AP
MACINNES, MA
KRAEMER, KH
AF OKINAKA, RT
PEREZ, A
LAUBSCHER, K
SENA, AP
MACINNES, MA
KRAEMER, KH
TI IDENTIFICATION OF MUTATIONS WITHIN THE ERCC-5 GENE IN A
XERODERMA-PIGMENTOSUM GROUP-G PEDIGREE
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 LOS ALAMOS NATL LAB,DIV LIFE SCI,LOS ALAMOS,NM 87545.
NCI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 285
EP 285
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401017
ER
PT J
AU UMAR, A
BOYER, JC
KUNKEL, TA
AF UMAR, A
BOYER, JC
KUNKEL, TA
TI A NOVEL DNA-REPAIR ACTIVITY CORRECTS UNPAIRED BASES IN MISMATCH REPAIR
(+/-)-HUMAN CELL-FREE-EXTRACTS
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIEHS,MOLEC GENET LAB,RES TRIANGLE PK,NC 27709.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 299
EP 299
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401073
ER
PT J
AU KOPSIDAS, G
MACPHEE, DG
AF KOPSIDAS, G
MACPHEE, DG
TI FRAMESHIFT MUTAGENESIS BY 9-AMINOACRIDINE - THE EFFECT OF MISMATCH
REPAIR
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NATL INST CHILD HLTH DEV,BETHESDA,MD 20892.
LA TROBE UNIV,DEPT MICROBIOL,BUNDOORA,VIC 3083,AUSTRALIA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 300
EP 300
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401078
ER
PT J
AU GORDENIN, D
TRAN, H
DEGTYAREVA, N
KOLOTEVA, N
RESNICK, M
AF GORDENIN, D
TRAN, H
DEGTYAREVA, N
KOLOTEVA, N
RESNICK, M
TI GENETIC-FACTORS AFFECTING REPLICATION SLIPPAGE BETWEEN DISTANT SHORT
REPEATS IN YEAST
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 ST PETERSBURG STATE UNIV,ST PETERSBURG,RUSSIA.
NIEHS,MOLEC GENET LAB,RES TRIANGLE PK,NC 27709.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 307
EP 307
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401103
ER
PT J
AU MITAS, M
DILL, J
YU, AD
KAMP, TJ
CHOCK, JY
HUANG, WJ
AF MITAS, M
DILL, J
YU, AD
KAMP, TJ
CHOCK, JY
HUANG, WJ
TI A MAMMALIAN PROTEIN FORMS SALT-STABLE COMPLEXES WITH SINGLE-STRANDED-DNA
FRAGMENTS THAT CONTAIN A MINIMUM OF 40 RESIDUES
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 OKLAHOMA STATE UNIV,DEPT BIOCHEM & MOLEC BIOL,STILLWATER,OK 74078.
JOHNS HOPKINS UNIV,SCH MED,DEPT MED,DIV CARDIOL,BALTIMORE,MD 21205.
NHLBI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 307
EP 307
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401104
ER
PT J
AU EVANS, MK
CHIN, KV
GOTTESMAN, MM
BOHR, VA
AF EVANS, MK
CHIN, KV
GOTTESMAN, MM
BOHR, VA
TI GENE-SPECIFIC DNA-REPAIR AND STEADY-STATE TRANSCRIPTION OF THE MDR1 GENE
IN HUMAN TUMOR-CELL LINES
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIA,BALTIMORE,MD 21224.
UNIV MED & DENT NEW JERSEY,PISCATAWAY,NJ 08854.
NCI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 311
EP 311
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401120
ER
PT J
AU BOHR, VA
APRHYS, C
LEE, M
JI, JP
CULLINANE, C
HJERTVIK, M
MAZUR, S
AF BOHR, VA
APRHYS, C
LEE, M
JI, JP
CULLINANE, C
HJERTVIK, M
MAZUR, S
TI NUCLEOTIDE EXCISION-REPAIR PATHWAYS
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIA,MOLEC GENET LAB,BALTIMORE,MD 21042.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 312
EP 312
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401123
ER
PT J
AU MAZUR, SJ
HANKINSON, A
BOHR, V
AF MAZUR, SJ
HANKINSON, A
BOHR, V
TI EFFECTS OF DOSE, ADDUCT DISTRIBUTION AND ADDUCT TYPE ON THE REPAIR OF
4-NITROQUINOLINE-1-OXIDE DAMAGE IN MAMMALIAN-CELLS
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIH,GERONTOL RES CTR,MOLEC GENET LAB,BALTIMORE,MD 21220.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 315
EP 315
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401138
ER
PT J
AU BISWAS, I
HSIEH, P
AF BISWAS, I
HSIEH, P
TI PARAMETERS THAT INFLUENCE DNA BRANCH MIGRATION
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIDDK,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 317
EP 317
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401143
ER
PT J
AU PERKINS, EL
HASHEM, VI
RESNICK, MA
AF PERKINS, EL
HASHEM, VI
RESNICK, MA
TI MANY HUMAN EXPRESSED GENES CAN BE CATEGORIZED ACCORDING TO PHENOTYPIC
CONSEQUENCES IN THE YEAST RAD52 MUTANT, COMPROMISED FOR CHROMOSOME
METABOLISM
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIEHS,MOLEC GENET LAB,RES TRIANGLE PK,NC 27709.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 322
EP 322
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401165
ER
PT J
AU BENNETT, CB
WESTMORELAND, TJ
SNIPE, JR
RESNICK, M
AF BENNETT, CB
WESTMORELAND, TJ
SNIPE, JR
RESNICK, M
TI LETHALITY, CHROMOSOME LOSS OR DELETION CAN RESULT FROM A SITE-SPECIFIC
DOUBLE-STRAND BREAK WITHIN A DISPENSABLE HUMAN YAC IN YEAST
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIEHS,MOLEC GENET LAB,RES TRIANGLE PK,NC 27709.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 331
EP 331
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401198
ER
PT J
AU KULAEVA, OI
WOOTTON, JC
LEVINE, AS
WOODGATE, R
AF KULAEVA, OI
WOOTTON, JC
LEVINE, AS
WOODGATE, R
TI CHARACTERIZATION OF THE UMU-COMPLEMENTING OPERON FROM R391
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NICHHD,DNA REPLICAT REPAIR & MUTAGENESIS,BETHESDA,MD 20892.
NIH,NATL LIB MED,NATL CTR BIOTECHNOL INFORMAT,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 332
EP 332
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401201
ER
PT J
AU KOCH, WH
WOODGATE, R
AF KOCH, WH
WOODGATE, R
TI IDENTIFICATION OF NEW UMUC HOMOLOGS BY DEGENERATE PRIMER PCR
AMPLIFICATION
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 US FDA,MOLEC BIOL BRANCH,WASHINGTON,DC 20204.
NICHHD,DNA REPLICAT REPAIR & MUTAGENESIS SECT,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 333
EP 333
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401205
ER
PT J
AU SEIDMAN, M
LEVY, D
AF SEIDMAN, M
LEVY, D
TI PROXIMAL AND DISTAL EFFECTS OF SEQUENCE CONTEXT ON ULTRAVIOLET
MUTATIONAL HOTSPOTS
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 OTSUKA PHARMACEUT CO LTD,ROCKVILLE,MD 20850.
NCI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 336
EP 336
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401218
ER
PT J
AU BEBENEK, K
BEARD, WA
DARDEN, TA
WILSON, SH
KUNKEL, TA
AF BEBENEK, K
BEARD, WA
DARDEN, TA
WILSON, SH
KUNKEL, TA
TI REDUCED FRAMESHIFT FIDELITY OF A REPLICATIVE POLYMERASE FROM HIV-1
CONTAINING MUTATIONS IN THE THUMB SUBDOMAIN
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIEHS,MOLEC GENET LAB,RES TRIANGLE PK,NC 27709.
UNIV TEXAS,MED BRANCH,SEALY CTR MOLEC SCI,GALVESTON,TX 77555.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 337
EP 337
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401221
ER
PT J
AU KRAEMER, KH
MORIWAKI, SI
TARONE, RE
TUCKER, MA
GOLDSTEIN, AM
AF KRAEMER, KH
MORIWAKI, SI
TARONE, RE
TUCKER, MA
GOLDSTEIN, AM
TI ULTRAVIOLET HYPERMUTABILITY IN MELANOMA-PRONE FAMILIES
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NCI,MOLEC CARCINOGENESIS LAB,BALTIMORE,MD 21211.
NCI,BIOSTAT BRANCH,BALTIMORE,MD 21211.
NCI,GENET EPIDEMIOL BRANCH,BALTIMORE,MD 21211.
RI Tucker, Margaret/B-4297-2015
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 339
EP 339
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401229
ER
PT J
AU FORNACE, AJ
ZHAN, QM
CHEN, IT
SMITH, ML
AF FORNACE, AJ
ZHAN, QM
CHEN, IT
SMITH, ML
TI EVIDENCE FOR INVOLVEMENT OF THE P53 DNA-DAMAGE RESPONSE PATHWAY IN
DNA-REPAIR
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NCI,DCT,DTP,MOLEC PHARMACOL LAB,BETHESDA,MD 20892.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 340
EP 340
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401234
ER
PT J
AU NAKAMURA, T
PICHEL, JG
WILLIAMSSIMONS, L
WESTPHAL, H
AF NAKAMURA, T
PICHEL, JG
WILLIAMSSIMONS, L
WESTPHAL, H
TI OVER-EXPRESSION OF WILD-TYPE AND A MUTANT HUMAN P53 IN THE LENS OF
TRANSGENIC MICE
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NICHHD,MAMMALIAN GENES & DEV LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 341
EP 341
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401238
ER
PT J
AU EPSTEIN, CJ
HUANG, TT
CARLSON, E
CHAN, PH
BRUNDIN, P
NAKAO, N
FRODL, E
WIDNER, H
CADET, JL
AF EPSTEIN, CJ
HUANG, TT
CARLSON, E
CHAN, PH
BRUNDIN, P
NAKAO, N
FRODL, E
WIDNER, H
CADET, JL
TI PROTECTIVE EFFECTS OF INCREASED EXPRESSION OF CUZN-SUPEROXIDE DISMUTASE
IN THE CENTRAL-NERVOUS-SYSTEM OF TRANSGENIC MICE
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIDA,ADDICT RES CTR,BALTIMORE,MD 21224.
UNIV CALIF SAN FRANCISCO,SAN FRANCISCO,CA 94143.
UNIV LUND HOSP,S-22185 LUND,SWEDEN.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 357
EP 357
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401286
ER
PT J
AU SNYDER, EY
MACKLIS, ID
WOLFE, JH
GINNS, EI
JENDOUBI, M
SIDMAN, RL
TESSLER, A
PROIA, RL
GOTTLIEB, DI
FRIEDMANN, T
YANDAVA, BD
FLAX, JD
AURORA, S
YOON, CH
MOZELL, RL
PAN, ZH
TAYLOR, RM
MCKINNEY, C
LACORAZZA, HD
ROSARIO, CM
KOSARAS, B
KITCHENS, DL
BAUM, L
AF SNYDER, EY
MACKLIS, ID
WOLFE, JH
GINNS, EI
JENDOUBI, M
SIDMAN, RL
TESSLER, A
PROIA, RL
GOTTLIEB, DI
FRIEDMANN, T
YANDAVA, BD
FLAX, JD
AURORA, S
YOON, CH
MOZELL, RL
PAN, ZH
TAYLOR, RM
MCKINNEY, C
LACORAZZA, HD
ROSARIO, CM
KOSARAS, B
KITCHENS, DL
BAUM, L
TI CNS PROGENITOR AND STEM-LIKE CELLS AS GENE DELIVERY VEHICLES AND
MEDIATORS OF REPAIR
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIDDK,BETHESDA,MD.
HARVARD UNIV,SCH MED,DEPT MED GENET,BOSTON,MA 02115.
UNIV PENN,SCH VET MED,PHILADELPHIA,PA 19104.
NIMH,BETHESDA,MD 20892.
NEI,BETHESDA,MD 20892.
NEW ENGLAND REG PRIMATE RES CTR,SOUTHBOROUGH,MA 01772.
MED COLL PENN,DEPT ANAT,PHILADELPHIA,PA 19129.
WASHINGTON UNIV,DEPT ANAT & NEUROBIOL,ST LOUIS,MO 63130.
UNIV CALIF SAN DIEGO,SCH MED,LA JOLLA,CA 92093.
RI Proia, Richard/A-7908-2012
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 357
EP 357
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401288
ER
PT J
AU FENIVES, ES
BLAESE, RM
TAICHMAN, LB
AF FENIVES, ES
BLAESE, RM
TAICHMAN, LB
TI CUTANEOUS GENE-THERAPY FOR ADA DEFICIENCY - A MODEL APPROACH FOR
INHERITED METABOLIC DISORDERS
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 SUNY STONY BROOK,DEPT ORAL BIOL & PATHOL,STONY BROOK,NY 11794.
NIH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 363
EP 363
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401307
ER
PT J
AU MARSH, JP
LANZA, RP
CHEN, L
NELSON, DM
MORGAN, RA
CHICK, WL
AF MARSH, JP
LANZA, RP
CHEN, L
NELSON, DM
MORGAN, RA
CHICK, WL
TI DELIVERY AND EXPRESSION OF HUMAN FACTOR-IX USING MICROREACTORS
CONTAINING GENETICALLY-MODIFIED FIBROBLASTS
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 BIOHYBRID TECHNOL INC,SHREWSBURY,MA 01545.
NIH,NATL CTR HUMAN GENE RES,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 368
EP 368
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401325
ER
PT J
AU NELSON, DM
METZGER, M
DONAHUE, R
MORGAN, RA
AF NELSON, DM
METZGER, M
DONAHUE, R
MORGAN, RA
TI DIRECT IN-VIVO RETROVIRAL-MEDIATED GENE-TRANSFER INTO HEMATOPOIETIC
PROGENITOR CELLS
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIH,NATL CTR HUMAN GENOME RES,BETHESDA,MD 20892.
NHLBI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 369
EP 369
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401330
ER
PT J
AU PUCK, J
ISAKOV, J
PEPPER, A
ROSENBERG, F
AF PUCK, J
ISAKOV, J
PEPPER, A
ROSENBERG, F
TI IL-2 RECEPTOR GAMMA-CHAIN MUTATIONS CAUSING HUMAN X-LINKED SCID ARE
VARIABLE - SOME MAY BE DOMINANT NEGATIVES WHEN COEXPRESSED WITH
WILD-TYPE
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIH,NATL CTR HUMAN GENOME RES,GENE TRANSFER LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 370
EP 370
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401335
ER
PT J
AU FARINA, SF
GIRARD, LJ
VANIN, EF
NIENHUIS, AW
BODINE, DM
AF FARINA, SF
GIRARD, LJ
VANIN, EF
NIENHUIS, AW
BODINE, DM
TI DYSREGULATED EXPRESSION OF GATA-1 FOLLOWING RETROVIRAL TRANSFER INTO
MURINE HEMATOPOIETIC STEM-CELLS INCREASES ERYTHROPOIESIS
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIH, NCHGR, HEMATOPOIESIS SECT, BETHESDA, MD 20892 USA.
ST JUDE CHILDRENS RES HOSP, MEMPHIS, TN 38101 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 376
EP 376
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401357
ER
PT J
AU HENGGE, UR
CHAN, EF
FOSTER, RA
WALKER, PS
VOGEL, JC
AF HENGGE, UR
CHAN, EF
FOSTER, RA
WALKER, PS
VOGEL, JC
TI TRANSIENT GENE-EXPRESSION IN EPIDERMIS FOLLOWING INJECTION OF NAKED DNA
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NCI,DERMATOL BRANCH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 377
EP 377
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401360
ER
PT J
AU OCONNELL, BC
TENHAGEN, K
TABAK, LA
BAUM, BJ
AF OCONNELL, BC
TENHAGEN, K
TABAK, LA
BAUM, BJ
TI ADENOVIRUS-MEDIATED DNA TRANSFER TO RAT SUBMANDIBULAR-GLAND IN-VIVO AND
ANALYSIS OF GLUTAMINE-GLUTAMIC ACID-RICH PROTEIN-REGULATION
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIDR,CIPCB,BETHESDA,MD 20892.
UNIV ROCHESTER,DEPT DENT RES,ROCHESTER,NY 14627.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 382
EP 382
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401379
ER
PT J
AU WALKER, PS
HENGGE, UR
VOGEL, JC
AF WALKER, PS
HENGGE, UR
VOGEL, JC
TI SIMULTANEOUS TRANSDUCTION OF KERATINOCYTES AND FIBROBLASTS WITH 2
RETROVIRAL VECTORS IN-VITRO
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NCI,DERMATOL BRANCH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 386
EP 386
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401396
ER
PT J
AU LACORAZZA, HD
FLAX, JD
SNYDER, EY
JENDOUBI, M
AF LACORAZZA, HD
FLAX, JD
SNYDER, EY
JENDOUBI, M
TI IN-VIVO GENE-TRANSFER AND EXPRESSION OF HUMAN BETA-HEXOSAMINIDASE
ALPHA-SUBUNIT INTO MOUSE-BRAIN
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NEI,IMMUNOL LAB,BETHESDA,MD 20892.
HARVARD UNIV,SCH MED,DEPT NEUROL,BOSTON,MA 02115.
HARVARD UNIV,SCH MED,DEPT PEDIAT,BOSTON,MA 02115.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 396
EP 396
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401434
ER
PT J
AU MORGAN, RA
CHUAH, M
VANDENDRIESSCHE, T
BUNNELL, B
BRESSLER, P
WALKER, R
LANE, C
BLAESE, RM
AF MORGAN, RA
CHUAH, M
VANDENDRIESSCHE, T
BUNNELL, B
BRESSLER, P
WALKER, R
LANE, C
BLAESE, RM
TI COMPARISON OF ANTI-HIV-1 RETROVIRAL VECTORS AND THEIR USE IN AN AIDS
GENE-THERAPY TRIAL IN IDENTICAL-TWINS
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NATL CTR HUMAN GENOME RES,BETHESDA,MD 20892.
NIAID,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 397
EP 397
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401438
ER
PT J
AU NUSSBAUM, RL
OLIVOS, I
JANNE, P
AF NUSSBAUM, RL
OLIVOS, I
JANNE, P
TI THE OCULOCEREBRORENAL SYNDROME GENE ENCODES A PROTEIN THAT LOCALIZES TO
THE GOLGI-COMPLEX
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NIH,NATL CTR HUMAN GENOME RES,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 398
EP 398
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401443
ER
PT J
AU KIEHNTOPF, M
BRACH, MA
LICHT, T
PETSCHAUER, S
KARAWAJEW, L
HERRMANN, F
AF KIEHNTOPF, M
BRACH, MA
LICHT, T
PETSCHAUER, S
KARAWAJEW, L
HERRMANN, F
TI MDR-1 SPECIFIC RIBOZYMES - AN ANTI-GENE THERAPY APPROACH TO REVERSE THE
DRUG-RESISTANT PHENOTYPE DURING ANTICANCER CHEMOTHERAPY
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 FREE UNIV BERLIN,KLINIKUM RUDOLF VIRCHOW,DEPT MED ONCOL & APPLE BIOL,W-1000 BERLIN 33,GERMANY.
ROBERT ROSSLE KLIN,BERLIN,GERMANY.
MAX DELBRUCK CTR MOLEC MED,BERLIN,GERMANY.
NCI,DCBDC,MOLEC BIOL LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 423
EP 423
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401539
ER
PT J
AU FELZMANN, T
RAMSEY, J
BLAESE, RM
AF FELZMANN, T
RAMSEY, J
BLAESE, RM
TI DEVELOPMENT OF ANIMAL-MODELS FOR THE TREATMENT OF HUMAN PAPILLOMA-VIRUS
INDUCED CARCINOMAS
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Meeting Abstract
C1 NCHGR,CLIN GENE THERAPY BRANCH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 10
PY 1995
SU 21A
BP 430
EP 430
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA QT864
UT WOS:A1995QT86401569
ER
PT J
AU WINKLER, JD
HONG, BC
BAHADOR, A
KAZANIETZ, MG
BLUMBERG, PM
AF WINKLER, JD
HONG, BC
BAHADOR, A
KAZANIETZ, MG
BLUMBERG, PM
TI METHODOLOGY FOR THE SYNTHESIS OF 3-OXYGENATED INGENANES - THE FIRST
INGENOL ANALOGS WITH HIGH-AFFINITY FOR PROTEIN-KINASE-C
SO JOURNAL OF ORGANIC CHEMISTRY
LA English
DT Article
ID TUMOR PROMOTERS; UNSATURATED CENTERS; PHORBOL ESTERS; CYCLO-ADDITION;
RING-SYSTEM; PROTOTYPE; RECEPTOR
AB Previous work from our laboratories has demonstrated that the intramolecular dioxenone photocycloaddition reaction leads to a stereoselective synthesis of the carbocyclic ring system of the ingenane diterpenes with the ''inside-outside'' stereochemical relationship that is required for biological activity. Two different approaches for the synthesis of C-3 oxygenated analogs of ingenol and the preparation of the first ingenane analog with high affinity for protein kinase C are described.
C1 NCI,CELLULAR CARCINOGENESIS & TUMOR PROMOT LAB,MOLEC MECHANISM TUMOR PROMOT SECT,BETHESDA,MD 20892.
RP WINKLER, JD (reprint author), UNIV PENN,DEPT CHEM,PHILADELPHIA,PA 19104, USA.
OI HONG, BOR-CHERNG/0000-0002-4623-3366
NR 25
TC 22
Z9 22
U1 0
U2 4
PU AMER CHEMICAL SOC
PI WASHINGTON
PA PO BOX 57136, WASHINGTON, DC 20037-0136
SN 0022-3263
J9 J ORG CHEM
JI J. Org. Chem.
PD MAR 10
PY 1995
VL 60
IS 5
BP 1381
EP 1390
DI 10.1021/jo00110a048
PG 10
WC Chemistry, Organic
SC Chemistry
GA QL605
UT WOS:A1995QL60500048
ER
PT J
AU PAUL, WE
AF PAUL, WE
TI AIDS RESEARCH POLICY
SO SCIENCE
LA English
DT Letter
RP PAUL, WE (reprint author), NIH,OFF AIDS RES,BLDG 10,BETHESDA,MD 20892, USA.
NR 2
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC ADVAN SCIENCE
PI WASHINGTON
PA 1333 H ST NW, WASHINGTON, DC 20005
SN 0036-8075
J9 SCIENCE
JI Science
PD MAR 10
PY 1995
VL 267
IS 5203
BP 1405
EP 1406
DI 10.1126/science.7878451
PG 2
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA QL497
UT WOS:A1995QL49700002
PM 7878451
ER
PT J
AU BROWN, K
GERSTBERGER, S
CARLSON, L
FRANZOSO, G
SIEBENLIST, U
AF BROWN, K
GERSTBERGER, S
CARLSON, L
FRANZOSO, G
SIEBENLIST, U
TI CENTRAL OF I-KAPPA-B-ALPHA PROTEOLYSIS BY SITE-SPECIFIC, SIGNAL-INDUCED
PHOSPHORYLATION
SO SCIENCE
LA English
DT Article
ID ONCOPROTEIN BCL-3; INHIBITION; PROTEINS; COMMON
AB I kappa B-alpha inhibits transcription factor NF-kappa B by retaining it in the cytoplasm. Various stimuli, typically those associated with stress or pathogens, rapidly inactivate I kappa B-alpha. This liberates NF-kappa B to translocate to the nucleus and initiate transcription of genes important for the defense of the organism. Activation of NF-kappa B correlates with phosphorylation of I kappa B-alpha and requires the proteolysis of this inhibitor. When either serine-32 or serine-36 of I kappa B-alpha was mutated, the protein did not undergo signal-induced phosphorylation or degradation, and NF-kappa B could not be activated. These results suggest that phosphorylation at one or both of these residues is critical for activation of NF-kappa B.
C1 NIAID,IMMUNOREGULAT LAB,BETHESDA,MD 20892.
NR 19
TC 1247
Z9 1268
U1 1
U2 8
PU AMER ASSOC ADVAN SCIENCE
PI WASHINGTON
PA 1333 H ST NW, WASHINGTON, DC 20005
SN 0036-8075
J9 SCIENCE
JI Science
PD MAR 10
PY 1995
VL 267
IS 5203
BP 1485
EP 1488
DI 10.1126/science.7878466
PG 4
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA QL497
UT WOS:A1995QL49700034
PM 7878466
ER
PT J
AU CLORE, GM
OMICHINSKI, JG
SAKAGUCHI, K
ZAMBRANO, N
SAKAMOTO, H
APPELLA, E
GRONENBORN, AM
AF CLORE, GM
OMICHINSKI, JG
SAKAGUCHI, K
ZAMBRANO, N
SAKAMOTO, H
APPELLA, E
GRONENBORN, AM
TI INTERHELICAL ANGLES IN THE SOLUTION STRUCTURE OF THE OLIGOMERIZATION
DOMAIN OF P53 (VOL 265, PG 386, 1994)
SO SCIENCE
LA English
DT Correction, Addition
ID PROTEIN STRUCTURES; RESONANCE
C1 NCI,CELL BIOL LAB,BETHESDA,MD 20892.
RP CLORE, GM (reprint author), NIDDKD,CHEM PHYS LAB,BETHESDA,MD 20892, USA.
RI Clore, G. Marius/A-3511-2008; Sakamoto, Hiroshi/A-3181-2011; Zambrano,
Nicola/B-9352-2014
OI Clore, G. Marius/0000-0003-3809-1027; Zambrano,
Nicola/0000-0001-9395-3481
NR 7
TC 66
Z9 75
U1 0
U2 5
PU AMER ASSOC ADVAN SCIENCE
PI WASHINGTON
PA 1333 H ST NW, WASHINGTON, DC 20005
SN 0036-8075
J9 SCIENCE
JI Science
PD MAR 10
PY 1995
VL 267
IS 5203
BP 1515
EP 1516
DI 10.1126/science.7878474
PG 2
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA QL497
UT WOS:A1995QL49700043
PM 7878474
ER
PT J
AU RUDENSEY, LM
KIMATA, JT
BENVENISTE, RE
OVERBAUGH, J
AF RUDENSEY, LM
KIMATA, JT
BENVENISTE, RE
OVERBAUGH, J
TI PROGRESSION TO AIDS IN MACAQUES IS ASSOCIATED WITH CHANGES IN THE
REPLICATION, TROPISM, AND CYTOPATHIC PROPERTIES OF THE SIMIAN
IMMUNODEFICIENCY VIRUS VARIANT POPULATION
SO VIROLOGY
LA English
DT Article
ID AMINO-ACID CHANGES; HUMAN CELL-LINES; MACROPHAGE TROPISM; ENVELOPE GENE;
HOST-RANGE; NEUTRALIZATION EPITOPE; MONONUCLEAR PHAGOCYTES; SYNCYTIUM
FORMATION; VIRAL DETERMINANTS; MOLECULAR CLONES
AB Human immunodeficiency virus type 1 (HIV-1) typically evolves from a macrophage-tropic, noncytopathic virus al early asymptomatic stages of infection to a T-cell-tropic, cytopathic, and syncytia-inducing virus population as humans progress to AIDS. This suggests that changes in virus phenotype may influence disease. Because simian immunodeficiency virus (SIV) infection in macaques is a common model system for HIV-1 pathogenesis, we determined whether SIV infection in macaques that develop simian AIDS is associated with a similar shift in viral tropism, replication, and cytopathic properties. The virus that infected the monkeys (SIVMneCL8) and predominated at early times in infection is a macrophage-tropic virus that replicates with relatively low efficiency in human T cell lines. The variant populations that arise in macaques as they progress to AIDS are more infectious for human T cell lines, exhibiting enhanced replication in CEMX174 cells and an expanded host range that includes Molt-4 Clone 8 cells. Infections starting with equal doses of the viruses demonstrated that the late variants are cytopathic and syncytia-inducing compared to SIVMneCL8, but the variants replicate less efficiently in primary macaque macrophages. Vs sequences were generally conserved between the early and the late variants, suggesting that changes in SIVMne tropism, replication, and cytopathicity were apparently not due to alterations in V3. This study demonstrates important similarities in the phenotypic viral changes that accompany development of AIDS in SIV and HIV-1 infections and suggest that SIV may provide a model system for determining whether the rapidly replicating, T-cell-tropic cytopathic variants present late in infection and disease are indeed important in determining progression to AIDS. (C) 1995 Academic Press, Inc.
C1 UNIV WASHINGTON,DEPT MICROBIOL,SEATTLE,WA 98195.
NCI,VIRAL CARCINOGENESIS LAB,FREDERICK,MD 21702.
FU NCI NIH HHS [T32-CA09229]; NCRR NIH HHS [RR00166]; NIAID NIH HHS [R01
AI034251, R01 AI34251]
NR 61
TC 57
Z9 58
U1 0
U2 1
PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
PI SAN DIEGO
PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495
SN 0042-6822
J9 VIROLOGY
JI Virology
PD MAR 10
PY 1995
VL 207
IS 2
BP 528
EP 542
DI 10.1006/viro.1995.1113
PG 15
WC Virology
SC Virology
GA QN321
UT WOS:A1995QN32100021
PM 7886956
ER
PT J
AU HONG, HL
DEVEREUX, TR
BOORMAN, GA
SILLS, RC
AF HONG, HL
DEVEREUX, TR
BOORMAN, GA
SILLS, RC
TI RAS ONCOGENE MUTATIONS IN HARDERIAN-GLAND NEOPLASMS OF B6C3F1 MICE
EXPOSED TO ISOPRENE FOR 6 MONTHS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS,NATL TOXICOL PROGRAM,RES TRIANGLE PK,NC 27709.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP 132
EP 132
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98700796
ER
PT J
AU JONES, JE
HANNIGAN, JL
SHAW, GL
LINNOILA, RI
AF JONES, JE
HANNIGAN, JL
SHAW, GL
LINNOILA, RI
TI A NOVEL POLYMORPHISM OF THE HUMAN AROMATIC HYDROCARBON (AH) RECEPTOR -
ASSOCIATION WITH INCREASED LUNG-CANCER RISK
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 UNIV S FLORIDA,H LEE MOFFITT CANC CTR,TAMPA,FL 33612.
NCI,DCPC,BPRB,ROCKVILLE,MD 20850.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP 134
EP 134
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98700806
ER
PT J
AU CLAUSEN, P
DUNN, J
BLAIR, D
AF CLAUSEN, P
DUNN, J
BLAIR, D
TI C-ETS-1 INDUCES DIFFERENTIATION OF ERYTHROLEUKEMIC CELL-LINES K562 AND
HEL
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,LMO,FREDERICK,MD 21702.
PRI DYNCORP,FREDERICK,MD 21702.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP 138
EP 138
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98700830
ER
PT J
AU RIVENSON, A
RAO, CV
STEELE, V
KELLOFF, G
REDDY, BS
AF RIVENSON, A
RAO, CV
STEELE, V
KELLOFF, G
REDDY, BS
TI INHIBITION OF 2-AMINO-1-METHYL-6-PHENYLIMIDAZO-[4,5-B]PYRIDINE
(PHIP)-INDUCED LYMPHOMA BY OLTIPRAZ IN RATS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 AMER HLTH FDN,VALHALLA,NY 10595.
NCI,BETHESDA,MD 20814.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP 139
EP 139
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98700840
ER
PT J
AU HILL, EM
BADER, T
NETTESHEIM, P
ELING, TE
AF HILL, EM
BADER, T
NETTESHEIM, P
ELING, TE
TI SELECTIVE EXPRESSION OF PROSTAGLANDIN-H SYNTHASE (PGHS) ISOZYMES AND
CYTOSOLIC PHOSPHOLIPASE A(2) (CPLA(2)) DURING DIFFERENTIATION OF RAT
TRACHEAL EPITHELIAL (RTE) CELLS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS,RES TRIANGLE PK,NC 27709.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP 147
EP 147
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98700882
ER
PT J
AU VIEIRA, NE
OBRIEN, KO
SPECKER, BL
YERGEY, AL
AF VIEIRA, NE
OBRIEN, KO
SPECKER, BL
YERGEY, AL
TI FRACTION OF DIET DERIVED URINARY CALCIUM UNCHANGED WITH LACTATION BUT
INCREASED WITH HIGHER INTAKE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NICHHD,BETHESDA,MD 20892.
UNIV CINCINNATI,MED CTR,DEPT PEDIAT,CINCINNATI,OH 45229.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP 161
EP 161
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98700963
ER
PT J
AU NEBELING, L
FORMAN, M
GRAUBARD, B
AF NEBELING, L
FORMAN, M
GRAUBARD, B
TI EFFECT OF HORMONAL USE AND LIFE-STYLE CHARACTERISTICS ON SPECIFIC AND
TOTAL CAROTENOID INTAKE IN US WOMEN
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,DIV CANC PREVENT & CONTROL,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP 171
EP 171
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98701022
ER
PT J
AU ABAD, L
RALL, L
HARRIS, TB
WILSON, PWF
DINARELLO, CA
ROUBENOFF, R
AF ABAD, L
RALL, L
HARRIS, TB
WILSON, PWF
DINARELLO, CA
ROUBENOFF, R
TI INFLAMMATORY CYTOKINE PRODUCTION IN AGING - DIVERGENCE BETWEEN AGONIST
AND ANTAGONIST RESPONSES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 TUFTS UNIV,HNRC,JMUSDA,BOSTON,MA 02111.
TUFTS UNIV NEW ENGLAND MED CTR,BOSTON,MA 02111.
FRAMINGHAM HEART DIS EPIDEMIOL STUDY,FRAMINGHAM,MA 01701.
NIA,EDBP,BETHESDA,MD 20892.
NR 0
TC 1
Z9 1
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A182
EP A182
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98701086
ER
PT J
AU BALLARDBARBASH, R
GRAUBARD, B
KREBSSMITH, S
THOMPSON, F
SCHATZKIN, A
AF BALLARDBARBASH, R
GRAUBARD, B
KREBSSMITH, S
THOMPSON, F
SCHATZKIN, A
TI CONTRIBUTION OF DIETING TO THE INVERSE ASSOCIATION BETWEEN ENERGY-INTAKE
AND BODY-MASS INDEX
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A282
EP A282
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98701659
ER
PT J
AU BOZZA, M
KOLAKOWSKI, LF
JENKINS, NA
GILBERT, DJ
COPELAND, NG
DAVID, JR
GERARD, C
AF BOZZA, M
KOLAKOWSKI, LF
JENKINS, NA
GILBERT, DJ
COPELAND, NG
DAVID, JR
GERARD, C
TI STRUCTURAL CHARACTERIZATION AND CHROMOSOMAL LOCATION OF THE MOUSE
MACROPHAGE-MIGRATION INHIBITORY FACTOR (MIF) GENE AND 5 PSEUDOGENES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 CHILDRENS HOSP,BOSTON,MA 02115.
HARVARD UNIV,SCH PUBL HLTH,BOSTON,MA 02115.
NCI,FREDERICK,MD 21702.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A534
EP A534
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98703113
ER
PT J
AU COLIGAN, JE
BRANDO, C
MARTINON, F
SHEVACH, EM
STURMHOFEL, K
AF COLIGAN, JE
BRANDO, C
MARTINON, F
SHEVACH, EM
STURMHOFEL, K
TI ANTIGEN-INDEPENDENT, INTEGRIN-MEDIATED T-CELL ACTIVATION
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAID,LMS,BETHESDA,MD 20892.
NIAID,LI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A233
EP A233
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98701376
ER
PT J
AU CONNORS, M
BOYLE, MJ
FLANIGAN, ME
GEIGER, SP
FORD, H
BASELER, M
ADELSBERGER, J
DAVEY, RT
LANE, HC
AF CONNORS, M
BOYLE, MJ
FLANIGAN, ME
GEIGER, SP
FORD, H
BASELER, M
ADELSBERGER, J
DAVEY, RT
LANE, HC
TI THE HU-HIV/PBL-SCID MOUSE - A MODIFIED HU-PBL-SCID MODEL FOR THE STUDY
OF HIV PATHOGENESIS AND THERAPY
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAID,LIR,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A210
EP A210
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98701249
ER
PT J
AU DAVENPECK, K
CHREST, F
BOCHNER, B
AF DAVENPECK, K
CHREST, F
BOCHNER, B
TI CARBOXYFLUORESCEIN DIACETATE (CFDA) LABELING DOES NOT AFFECT ADHESION
MOLECULE (AM) EXPRESSION OR FUNCTION IN HUMAN EOSINOPHILS (EOS) OR
NEUTROPHILS (PMN)
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 JOHNS HOPKINS UNIV,SCH MED,BALTIMORE,MD 21224.
NIA,BALTIMORE,MD 21224.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A311
EP A311
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98701828
ER
PT J
AU DISALVO, J
KLEINMAN, HK
NELSON, S
AF DISALVO, J
KLEINMAN, HK
NELSON, S
TI LAMININ, PLATELET-DERIVED GROWTH-FACTOR (PDGF) AND TYR-KINASE ACTIVITY
PROMOTE NETWORKING OF VASCULAR SMOOTH-MUSCLE CELLS (VSMC) ON
RECONSTITUTED BASEMENT-MEMBRANE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 UNIV MINNESOTA,DULUTH,MN 55812.
NIDR,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A295
EP A295
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98701731
ER
PT J
AU EBERLY, KW
GHOSH, P
YOUNG, H
AF EBERLY, KW
GHOSH, P
YOUNG, H
TI BIOCHEMICAL PATHWAYS OF FLAVONE-8-ACETIC ACID GENE INDUCTION
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,FREDERICK CANC RES & DEV CTR,LEI,FREDERICK,MD 21701.
ST MARYS COLL,NOTRE DAME,IN 46556.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A509
EP A509
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98702973
ER
PT J
AU EBNET, K
LUCE, GEG
FARBER, JM
SHAW, S
AF EBNET, K
LUCE, GEG
FARBER, JM
SHAW, S
TI EXPRESSION OF THE MIG CXC CHEMOKINE GENE BY HUMAN ENDOTHELIAL-CELLS -
SIMILARITIES AND DIFFERENCES TO OTHER CHEMOKINES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,BETHESDA,MD 20892.
NIAID,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A199
EP A199
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98701184
ER
PT J
AU ERSHOW, A
AF ERSHOW, A
TI DIETARY-EFFECTS ON LIPOPROTEINS AND THROMBOGENIC ACTIVITY - RATIONALE
AND DESIGN OF THE DELTA STUDY
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,BETHESDA,MD 20892.
NR 0
TC 2
Z9 2
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A289
EP A289
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98701697
ER
PT J
AU FINOTTO, S
OH, CK
NAGATA, H
METCALFE, DD
AF FINOTTO, S
OH, CK
NAGATA, H
METCALFE, DD
TI EVIDENCE FOR TISSUE-SPECIFIC ALTERNATIVE SPLICING OF STEM-CELL FACTOR
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A488
EP A488
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98702850
ER
PT J
AU FOGLER, WE
MCCORMICK, KL
VOLKER, K
ORTALDO, JR
WILTROUT, RH
AF FOGLER, WE
MCCORMICK, KL
VOLKER, K
ORTALDO, JR
WILTROUT, RH
TI NK CELL INFILTRATION INTO LUNG IS PRIMARILY REGULATED BY VCAM-1
INTERACTION
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 BRMP,LEI,EXPTL THERAPEUT SECT,FREDERICK,MD 21702.
NCI,FREDERICK CANC RES & DEV CTR,PRI DYNCORP,BCDP,FREDERICK,MD 21702.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A219
EP A219
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98701300
ER
PT J
AU FREDERICK, DW
HICKS, LH
WRIGHT, JM
AF FREDERICK, DW
HICKS, LH
WRIGHT, JM
TI WHOLE-CELL PATCH-CLAMP STUDY OF ENZYME EFFECTS ON N-METHYL-D-ASPARTIC
ACID (NMDA) RECEPTORS IN CULTURED MOUSE CORTICAL-NEURONS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 HOWARD UNIV,WASHINGTON,DC 20059.
NIAAA,MOLEC & CELLULAR NEUROBIOL LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A374
EP A374
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98702189
ER
PT J
AU FREEMAN, S
KING, JC
VIEIRA, NE
WOODHOUSE, LR
YERGEY, AL
AF FREEMAN, S
KING, JC
VIEIRA, NE
WOODHOUSE, LR
YERGEY, AL
TI 41CA AS A TRACER FOR CALCIUM-METABOLISM IN HUMANS MEASURED BY
ACCELERATOR MASS-SPECTROMETRY
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 LAWRENCE LIVERMORE NATL LAB,LIVERMORE,CA 94551.
UNIV CALIF BERKELEY,DEPT NUTR SCI,BERKELEY,CA 94720.
NICHHD,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A284
EP A284
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98701668
ER
PT J
AU GLASGOW, WC
EVERHART, AE
AF GLASGOW, WC
EVERHART, AE
TI ROLE OF LINOLEIC AND ARACHIDONIC-ACID METABOLISM IN REGULATING
MITOGENESIS IN ERBB-2 TRANSFORMED-CELLS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS,RES TRIANGLE PK,NC 27709.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A113
EP A113
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98700659
ER
PT J
AU GOLDING, B
GOLDING, H
INMAN, J
SCOTT, DE
AF GOLDING, B
GOLDING, H
INMAN, J
SCOTT, DE
TI HIV V3 PEPTIDE CONJUGATED TO BRUCELLA-ABORTUS IS IMMUNOGENIC IN CD4+
T-CELL DEFICIENT MICE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 US FDA,BETHESDA,MD 20892.
NIH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A207
EP A207
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98701229
ER
PT J
AU GUEGUEN, M
LONG, EO
AF GUEGUEN, M
LONG, EO
TI THE PROCESSING PATHWAY FOR THE PRESENTATION OF CYTOSOLIC ANTIGEN BY MHC
CLASS-II INVOLVES LONG-LIVED PROTEINS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAID,IMMUNOGENET LAB,ROCKVILLE,MD 20852.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A530
EP A530
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98703092
ER
PT J
AU HARRIS, HW
FUKUYAMA, R
AF HARRIS, HW
FUKUYAMA, R
TI NEURONAL DIFFERENTIATION OF PC12 CELLS IN THE ABSENCE OF
EXTRACELLULAR-MATRIX ADHESION INDUCES APOPTOSIS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIA,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A581
EP A581
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98703389
ER
PT J
AU HENKIN, RI
MARTIN, BM
DAL, WL
AF HENKIN, RI
MARTIN, BM
DAL, WL
TI A MAGNESIUM PROTEIN FOUND IN HUMAN PAROTID-SALIVA
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIMH,CLIN NEUROSCI BRANCH,BETHESDA,MD 20205.
TASTE & SMELL CLIN,WASHINGTON,DC 20016.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A452
EP A452
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98702646
ER
PT J
AU HONG, HL
DEVEREUX, TR
BOORMAN, GA
SILLS, RC
AF HONG, HL
DEVEREUX, TR
BOORMAN, GA
SILLS, RC
TI RAS ONCOGENE MUTATIONS IN HARDERIAN-GLAND NEOPLASMS OF B6C3F1 MICE
EXPOSED TO ISOPRENE FOR 6 MONTHS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS,NATL TOXICOL PROGRAM,RES TRIANGLE PK,NC 27709.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A132
EP A132
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98700772
ER
PT J
AU HUI, R
EVERHART, AL
GLASGOW, WC
AF HUI, R
EVERHART, AL
GLASGOW, WC
TI EPIDERMAL GROWTH FACTOR-STIMULATED INCORPORATION OF 13(S)-HODE IS
ASSOCIATED WITH TUMOR-SUPPRESSOR GENE PHENOTYPE IN SYRIAN-HAMSTER
EMBRYO(SHE) FIBROBLASTS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS,RES TRIANGLE PK,NC 27709.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A113
EP A113
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98700662
ER
PT J
AU IRVINE, KR
MCFARLAND, BJ
ROSENBERG, SA
RESTIFO, NP
AF IRVINE, KR
MCFARLAND, BJ
ROSENBERG, SA
RESTIFO, NP
TI SYNTHETIC OLIGONUCLEOTIDE EXPRESSED BY RECOMBINANT VACCINIA VIRUS
ELICITS THERAPEUTIC CYTOLYTIC T-LYMPHOCYTES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,SURG BRANCH,BETHESDA,MD 20892.
RI Restifo, Nicholas/A-5713-2008
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A494
EP A494
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98702884
ER
PT J
AU ISSEKUTZ, TB
TAUB, D
SCHALL, TJ
AF ISSEKUTZ, TB
TAUB, D
SCHALL, TJ
TI EFFECT OF BETA-CHEMOKINES ON MONOCYTE AND LYMPHOCYTE RECRUITMENT IN-VIVO
AND INHIBITION BY CD11/CD18 AND VLA-4 INTEGRIN BLOCKADE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 UNIV TORONTO,TORONTO,ON,CANADA.
NCI,FREDERICK,MD 21701.
DNAX RES INST MOLEC & CELLULAR BIOL INC,PALO ALTO,CA 94304.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A270
EP A270
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98701590
ER
PT J
AU JANKOVIC, D
ASLUND, L
OSWALD, LP
CASPAR, P
SHER, A
JAMES, SL
AF JANKOVIC, D
ASLUND, L
OSWALD, LP
CASPAR, P
SHER, A
JAMES, SL
TI CALPAIN IS THE TARGET ANTIGEN OF A TH1 CLONE WHICH TRANSFERS PROTECTIVE
IMMUNITY AGAINST SCHISTOSOMA-MANSONI
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAID,PARASIT DIS LAB,IMMUNOBIOL SECT,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A490
EP A490
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98702862
ER
PT J
AU JUN, D
PARK, HK
LEE, YH
KIM, Y
NAGEL, J
NORDIN, A
AF JUN, D
PARK, HK
LEE, YH
KIM, Y
NAGEL, J
NORDIN, A
TI GENOMIC ORGANIZATION OF MURINE HOMOLOGS OF CDC2 AND CDK2
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 KYUNGPOOK NATL UNIV,DEPT MICROBIOL,TAEGU 702701,SOUTH KOREA.
NIA,GERONTOL RES CTR,BALTIMORE,MD 21224.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A233
EP A233
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98701379
ER
PT J
AU KANT, AK
BALLARDBARBASH, R
SCHATZKIN, A
AF KANT, AK
BALLARDBARBASH, R
SCHATZKIN, A
TI EVENING EATING AND SUBSEQUENT WEIGHT CHANGE IN THE NHANES-I
EPIDEMIOLOGIC FOLLOW-UP-STUDY (NHEFS)
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 CUNY QUEENS COLL,FLUSHING,NY 11367.
NCI,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A282
EP A282
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98701661
ER
PT J
AU KAPLAN, D
STEPHENS, R
RASOULY, D
MICHAUD, N
PENG, X
GREENE, L
AF KAPLAN, D
STEPHENS, R
RASOULY, D
MICHAUD, N
PENG, X
GREENE, L
TI SIGNAL-TRANSDUCTION BY TRK RECEPTORS IN NEURONAL CELLS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,FREDERICK,MD.
COLUMBIA UNIV,DEPT PATHOL,NEW YORK,NY.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A267
EP A267
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98701575
ER
PT J
AU KARI, F
SLADE, R
CRISSMAN, K
LUSTER, M
HATCH, G
AF KARI, F
SLADE, R
CRISSMAN, K
LUSTER, M
HATCH, G
TI DIETARY RESTRICTION MITIGATES OZONE-INDUCED LUNG TOXICITY IN RATS - ROLE
OF ASCORBATE
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS,RES TRIANGLE PK,NC 27719.
US EPA,RES TRIANGLE PK,NC 27719.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A413
EP A413
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98702417
ER
PT J
AU KELLY, GD
ORIJI, GK
TATE, JE
KEISER, HR
AF KELLY, GD
ORIJI, GK
TATE, JE
KEISER, HR
TI ENDOTHELIN-INDUCED PROSTACYCLIN PRODUCTION IN RAT AORTIC RINGS IS
MEDITATED BY PROTEIN-KINASE-C
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,HYPERTENS ENDOCRINE BRANCH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A110
EP A110
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98700646
ER
PT J
AU KENNEY, MA
MCCOY, H
CHAPIN, RE
KU, WW
LIU, Y
WILLIAMS, L
AF KENNEY, MA
MCCOY, H
CHAPIN, RE
KU, WW
LIU, Y
WILLIAMS, L
TI MECHANICAL-PROPERTIES OF BONES OF RATS FED A COMPLETE DIET PLUS
BORIC-ACID
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS,RES TRIANGLE PK,NC 27709.
UNIV ARKANSAS,FAYETTEVILLE,AR 72701.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A447
EP A447
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98702611
ER
PT J
AU KIM, JH
WESS, J
SCHONEBERG, T
JACOBSON, KA
AF KIM, JH
WESS, J
SCHONEBERG, T
JACOBSON, KA
TI SITE-DIRECTED MUTAGENESIS IDENTIFIES RESIDUES INVOLVED IN LIGAND
RECOGNITION IN THE HUMAN A(2A) ADENOSINE RECEPTOR
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIDDK,LBC,MOLEC RECOGNIT SECT,BETHESDA,MD 20892.
RI Jacobson, Kenneth/A-1530-2009
OI Jacobson, Kenneth/0000-0001-8104-1493
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A122
EP A122
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98700712
ER
PT J
AU KITZLER, JW
REDDY, N
ELING, TE
AF KITZLER, JW
REDDY, N
ELING, TE
TI CLONING SEQUENCING AND EXPRESSION OF A 5-LIPOXYGENASE ORTHOLOG FROM
SYRIAN-HAMSTER EMBRYO FIBROBLASTS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIEHS,EICOSANOID BIOCHEM SECT,MOLEC BIOPHYS LAB,RES TRIANGLE PK,NC 27709.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A112
EP A112
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98700657
ER
PT J
AU KOSHIBA, M
APASOV, S
CHEN, P
SYERDLOV, V
TURNER, J
WEISSMAN, G
SITKOVSKY, M
AF KOSHIBA, M
APASOV, S
CHEN, P
SYERDLOV, V
TURNER, J
WEISSMAN, G
SITKOVSKY, M
TI COMPARATIVE-STUDIES OF THE EXPRESSION OF THE P2U AND P2X PURINERGIC
RECEPTORS IN DIFFERENT SUBPOPULATIONS OF T-CELLS AT DIFFERENT STAGES OF
DIFFERENTIATION AND ACTIVATION
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAID,IMMUNOL LAB,BETHESDA,MD 20892.
UNIV MISSOURI,COLUMBIA,MO 65212.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A116
EP A116
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98700681
ER
PT J
AU KWON, BS
YOUN, BS
KIM, SH
BROXMEYER, HE
JENKINS, N
COPELAND, NG
AF KWON, BS
YOUN, BS
KIM, SH
BROXMEYER, HE
JENKINS, N
COPELAND, NG
TI A NOVEL CHEMOKINE MRP-2 INHIBITS COLONY FORMATION OF BONE-MARROW MYELOID
PROGENITORS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 INDIANA UNIV,SCH MED,INDIANAPOLIS,IN 46202.
FREDERICK CANC RES & DEV CTR,FREDERICK,MD 21702.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A246
EP A246
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98701451
ER
PT J
AU LEDERER, JA
LIOU, JS
RICE, NR
LICHTMAN, AH
AF LEDERER, JA
LIOU, JS
RICE, NR
LICHTMAN, AH
TI DIFFERENTIAL NF-KAPPA-B REGULATION IN TH1 AND TH2 CELLS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 BRIGHAM & WOMENS HOSP,BOSTON,MA 02115.
NCI,FREDERICK CANC RES & DEV CTR,FREDERICK,MD.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A536
EP A536
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98703127
ER
PT J
AU LI, Z
MIYASHITA, Y
CHENG, L
LAKATTA, E
FROEHLICH, J
AF LI, Z
MIYASHITA, Y
CHENG, L
LAKATTA, E
FROEHLICH, J
TI REMODELING OF THE RAT AORTIC-WALL DURING AGING
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIA,GERONTOL RES CTR,BALTIMORE,MD 21224.
NR 0
TC 4
Z9 4
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A606
EP A606
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98703536
ER
PT J
AU LIAO, F
RABIN, R
YANNELLI, J
KONIARIS, L
VANGURI, P
FARBER, J
AF LIAO, F
RABIN, R
YANNELLI, J
KONIARIS, L
VANGURI, P
FARBER, J
TI HUMAN MIG IS A CXC CHEMOKINE THAT TARGETS ACTIVATED T-CELLS AND THAT IS
PRODUCED AS A COLLECTION OF PROTEOLYTICALLY PROCESSED FORMS OF DIFFERING
SPECIFIC ACTIVITIES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAID,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A199
EP A199
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98701183
ER
PT J
AU LONGO, DL
FUNAKOSHI, S
ARMITAGE, RJ
FANSLOW, WC
MURPHY, WJ
AF LONGO, DL
FUNAKOSHI, S
ARMITAGE, RJ
FANSLOW, WC
MURPHY, WJ
TI INHIBITION OF HUMAN B-CELL LYMPHOMA GROWTH BY SOLUBLE RECOMBINANT HUMAN
CD40 LIGAND
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,FREDERICK CANC RES & DEV CTR,DIV CANC TREATMENT,BRMP,LLB,FREDERICK,MD 21702.
NCI,FREDERICK CANC RES & DEV CTR,PRI DYNCORP,BCDP,FREDERICK,MD 21702.
IMMUNEX RES & DEV CORP,SEATTLE,WA 98101.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A205
EP A205
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98701218
ER
PT J
AU MANSOOR, A
STEVENSON, MS
WEISS, W
AHMAN, M
KHAN, A
MUSHTAQ, S
JAFFE, ES
KINGMA, DW
AF MANSOOR, A
STEVENSON, MS
WEISS, W
AHMAN, M
KHAN, A
MUSHTAQ, S
JAFFE, ES
KINGMA, DW
TI EPSTEIN-BARR-VIRUS (EBV) IS FREQUENTLY ASSOCIATED WITH SPORADIC
AGGRESSIVE NON-HODGKINS (NHL) LYMPHOMA FROM PAKISTAN
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH,BETHESDA,MD 20892.
AFIP,RAWALPINDI,PAKISTAN.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A273
EP A273
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98701605
ER
PT J
AU MASON, L
ORTALDO, JR
AF MASON, L
ORTALDO, JR
TI MAB 12A8 IDENTIFIES A UNIQUE SUBSET OF MURINE NK CELLS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,FREDERICK CANC RES & DEV CTR,DIV CANC TREATMENT,BRMP,LEI,FREDERICK,MD 21702.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A220
EP A220
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98701301
ER
PT J
AU MCCARTNEYFRANCIS, N
MIZEL, D
REDMAN, R
FRAZIERJESSEN, M
PANEK, R
KULKARNI, A
WARD, J
WAHL, S
AF MCCARTNEYFRANCIS, N
MIZEL, D
REDMAN, R
FRAZIERJESSEN, M
PANEK, R
KULKARNI, A
WARD, J
WAHL, S
TI LOSS-OF-FUNCTION MUTATION OF THE TGF-BETA-1 GENE RESULTS SALIVARY-GLAND
ABNORMALITIES
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NINCDS,NIDR,BETHESDA,MD 20878.
VET ADM MED CTR,WASHINGTON,DC 20422.
NCI,FREDERICK,MD 21702.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A512
EP A512
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98702986
ER
PT J
AU MCCOY, H
KENNEY, MA
CHAPIN, RE
KU, WW
LIU, Y
WILLIAMS, L
AF MCCOY, H
KENNEY, MA
CHAPIN, RE
KU, WW
LIU, Y
WILLIAMS, L
TI DOES GENDER AFFECT RESPONSE OF BONE TO SUPPLEMENTAL BORON
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 UNIV ARKANSAS,FAYETTEVILLE,AR 72701.
NIEHS,RES TRIANGLE PK,NC 27709.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A447
EP A447
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98702614
ER
PT J
AU MONTUORI, N
SIRI, J
SIMMONS, T
GILLET, C
SENTERRE, G
WRATHALL, L
SOBEL, ME
AF MONTUORI, N
SIRI, J
SIMMONS, T
GILLET, C
SENTERRE, G
WRATHALL, L
SOBEL, ME
TI PRECURSOR-PRODUCT RELATIONSHIP BETWEEN A 37-KDA POLYPEPTIDE AND THE
67-KDA LAMININ RECEPTOR
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NCI,PATHOL LAB,BETHESDA,MD 20892.
RI Montuori, Nunzia/J-8542-2013
NR 0
TC 4
Z9 4
U1 0
U2 3
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A539
EP A539
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98703144
ER
PT J
AU NEURATH, MF
STUBER, ER
MAX, EE
STROBER, W
AF NEURATH, MF
STUBER, ER
MAX, EE
STROBER, W
TI THE TRANSCRIPTION FACTOR BSAP REPRESSES THE IMMUNOGLOBULIN HEAVY-CHAIN
3'ALPHA ENHANCER IN-VIVO BY INHIBITION OF BINDING OF NF-ALPHA-P, AN
ETS-LIKE PROTEIN THAT CONTROLS IG GENE-TRANSCRIPTION
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIAID,LCI,MIS,BETHESDA,MD 20892.
US FDA,CYBER,CELL & VIRAL REGULAT LAB,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A196
EP A196
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98701169
ER
PT J
AU NOVOTNY, JA
DUEKER, SR
ZECH, LA
CLIFFORD, AJ
AF NOVOTNY, JA
DUEKER, SR
ZECH, LA
CLIFFORD, AJ
TI THE KINETICS OF BETA-CAROTENE METABOLISM IN HUMANS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 USDA,BELTSVILLE HUMAN NUTR RES CTR,RES LAB,BELTSVILLE,MD 20705.
NCI,BETHESDA,MD 20892.
UNIV CALIF DAVIS,DAVIS,CA 95616.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A443
EP A443
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98702590
ER
PT J
AU OH, CK
METCALFE, DD
AF OH, CK
METCALFE, DD
TI IDENTIFICATION AND CHARACTERIZATION OF NEGATIVE REGULATORY ELEMENTS OF
T-CELL ACTIVATION GENE-3
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NIH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A199
EP A199
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98701182
ER
PT J
AU ORIJI, GK
KELLY, GD
PIERUZZI, FU
KEISER, HR
AF ORIJI, GK
KELLY, GD
PIERUZZI, FU
KEISER, HR
TI EFFECT OF PROTEIN-KINASE-C ON CONTRACTIONS EVOKED BY ENDOTHELIN IN RAT
AORTIC RINGS
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 NHLBI,HYPERTENS ENDOCRINE BRANCH,BETHESDA,MD 20892.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD MAR 9
PY 1995
VL 9
IS 3
BP A615
EP A615
PN 1
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA QL987
UT WOS:A1995QL98703590
ER
EF