FN Thomson Reuters Web of Science™ VR 1.0 PT J AU REGAN, JA KLEBANOFF, MA NUGENT, RP AF REGAN, JA KLEBANOFF, MA NUGENT, RP TI THE EPIDEMIOLOGY OF GROUP-B STREPTOCOCCAL COLONIZATION IN PREGNANCY SO OBSTETRICS AND GYNECOLOGY LA English DT Article ID WOMEN; TRANSMISSION AB Risk factors for cervicovaginal group B streptococcal colonization at 23-26 weeks' gestation were studied in 7742 women participating in the Vaginal Infections and Prematurity study. The prevalence of group B Streptococcus was 18.6%, and was greatest in (predominantly Caribbean) Hispanics from New York City, followed by blacks, whites, and other (predominantly Mexican) Hispanics. Group B Streptococcus was more common among older women and women of lower parity, and less common among women living with their partner compared with those living alone. Current smoking was associated with a decreased risk of colonization, and group B Streptococcus was less common among women with more education. Increased risk was seen only with extreme increases in sexual activity including both frequent intercourse and multiple partners during the previous year. The risk of colonization was greater when there was concurrent colonization with Candida sp, but group B Streptococcus was not associated with carriage of Chlamydia trachomatis, Ureaplasma urealyticum, Trichomonas vaginalis, and Mycoplasma hominis. External genital erythema and scaling, purulent vaginal discharge, and pH greater than 5 were associated with increased colonization. Although these associations can raise the clinical index of suspicion for group B streptococcal colonization in a given patient, the study data did not enable us to select a small group of women with a very high probability of colonization. We conclude that selective screening is not useful in detecting group B streptococcal colonization in pregnancy. C1 NICHHD,DIV PREVENT RES,EPN 640,BETHESDA,MD 20892. COLUMBIA UNIV COLL PHYS & SURG,DEPT PEDIAT,NEW YORK,NY 10032. FU NICHD NIH HHS [HD-3-2832, HD-3-2833, HD-3-2834] NR 19 TC 202 Z9 213 U1 3 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD APR PY 1991 VL 77 IS 4 BP 604 EP 610 PG 7 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA FD561 UT WOS:A1991FD56100024 PM 2002986 ER PT J AU RAPP, UR AF RAPP, UR TI ROLE OF RAF-1 SERINE THREONINE PROTEIN-KINASE IN GROWTH-FACTOR SIGNAL TRANSDUCTION SO ONCOGENE LA English DT Article ID A-RAF; V-RAF; CARRYING RETROVIRUS; SRC FAMILY; C-FOS; ONCOGENE; PHOSPHORYLATION; ACTIVATION; CELLS; TRANSFORMATION RP RAPP, UR (reprint author), NCI,FREDERICK CANC RES & DEV CTR,VIRAL CARCINOGENESIS LAB,FREDERICK,MD 21702, USA. NR 43 TC 261 Z9 262 U1 0 U2 2 PU STOCKTON PRESS PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS SN 0950-9232 J9 ONCOGENE JI Oncogene PD APR PY 1991 VL 6 IS 4 BP 495 EP 500 PG 6 WC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity SC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity GA FR939 UT WOS:A1991FR93900001 PM 2030909 ER PT J AU JORCYK, CL WATSON, DK MAVROTHALASSITIS, GJ PAPAS, TS AF JORCYK, CL WATSON, DK MAVROTHALASSITIS, GJ PAPAS, TS TI THE HUMAN ETS1 GENE - GENOMIC STRUCTURE, PROMOTER CHARACTERIZATION AND ALTERNATIVE SPLICING SO ONCOGENE LA English DT Article ID LONG TERMINAL REPEAT; ONCOGENE C-ETS; PROTO-ONCOGENE; TRANSCRIPTION FACTOR; FUNCTIONAL-CHARACTERIZATION; TRANSFORMING GENE; NUCLEAR PROTEINS; LEUKEMIA VIRUSES; E26 RETROVIRUS; SARCOMA-VIRUS AB Genomic clones encompassing the human ETS1 gene were isolated and utilized to define its molecular organization. This gene consists of eight exons spanning over 60 kb. The 5' end of the human ETS1 gene was subcloned and characterized. S1 nuclease, primer extension and RNAase protection analyses of human mRNAs showed multiple transcription initiation sites. DNA sequence analysis indicated a high G + C content in the promoter region and the absence of either a 'TATA' box or a 'CAAT' box. Six consensus recognition sequences for the transcription factor SP1, two AP1 consensus sequences and one consensus AP2 recognition sequence were identified, as well as two GC elements with dyad symmetry. A palindromic region similar to the serum response element of the c-fos gene and two octamer consensus recognition sequences were located upstream of the promoter region. A series of promoter deletion constructs positioned upstream from the bacterial chloramphenicol acetyl transferase gene were transfected into HeLa cells and their functional promoter activity assayed. The deletion constructs identified the 5' boundary for maximum promoter activity at 486 bp upstream of the first initiation site and suggest possible positive and negative regulatory regions. Polymerase chain reaction analysis of ETS1 cDNA identified several amplified products, indicating alternative splicing. In addition to the presence of mRNA products lacking exon VII, products lacking exon IV, as well as ones lacking both exons IV and VII, were found. RP JORCYK, CL (reprint author), NCI,MOLEC ONCOL LAB,FREDERICK,MD 21702, USA. NR 64 TC 101 Z9 101 U1 1 U2 3 PU STOCKTON PRESS PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS SN 0950-9232 J9 ONCOGENE JI Oncogene PD APR PY 1991 VL 6 IS 4 BP 523 EP 532 PG 10 WC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity SC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity GA FR939 UT WOS:A1991FR93900005 PM 2030910 ER PT J AU COLLETTA, G CIRAFICI, AM DICARLO, A CIARDIELLO, F SALOMON, DS VECCHIO, G AF COLLETTA, G CIRAFICI, AM DICARLO, A CIARDIELLO, F SALOMON, DS VECCHIO, G TI CONSTITUTIVE EXPRESSION OF TRANSFORMING GROWTH FACTOR-ALPHA DOES NOT TRANSFORM RAT-THYROID EPITHELIAL-CELLS SO ONCOGENE LA English DT Note ID MURINE SARCOMA-VIRUS; ACCOMPANIES VIRAL TRANSFORMATION; TGF-ALPHA; INDUCTION; PHENOTYPE; BETA; RESPONSIVENESS; PROTOONCOGENE; KERATINOCYTES; FIBROBLASTS AB To evaluate the role of transforming growth factor-alpha (TGF-alpha) in transformed rat thyroid epithelial cells, expression and production of TGF-alpha were measured in a normal rat thyroid epithelial cell line, FRTL-5, and in the same cells transformed by the Ki-ras oncogene. FRTL-5 cells transformed with Ki-ras exhibit a 5- to 7-fold increase in the levels of TGF-alpha-specific mRNA and a 3- to 4-fold enhancement of the amounts of TGF-alpha protein in the conditioned medium, as compared with the normal thyroid cells. Although conditioned medium from the Ki-ras transformed FRTL-5 cells or authentic epidermal growth factor or TGF-alpha are able to stimulate the anchorage-dependent growth of nontransformed FRTL-5 cells, neither conditioned medium nor the growth factors are able to induce the anchorage-independent growth of these cells in soft agar. FRTL-5 cells were then transfected with an expression vector plasmid containing the human TGF-alpha cDNA to directly ascertain if overexpression of this growth factor is able to induce transformation in these cells. The TGF-alpha-transfected FRTL-5 clones constitutively produced high amounts of TGF-alpha at a level equivalent to or greater than the level found in the conditioned medium from the Ki-ras transformed FRTL-5 clones. Moreover, in contrast to the Ki-ras transformed cells, the TGF-alpha transfectants were unable to grow in soft agar, did not form tumors in nude mice, and showed no reduction in the secretion of thyroglobulin. These data demonstrate that unlike Ki-ras, the constitutive expression of biologically active TGF-alpha is not entirely sufficient to elicit a transformed phenotype in these cells. C1 NCI,TUMOR IMMUNOL & BIOL LAB,BETHESDA,MD 20892. RP COLLETTA, G (reprint author), FAC MED & CHIRURG NAPLES,DIPARTIMENTO BIOL & PATOL CELLULARE & MOLEC,CNR,I-80121 NAPLES,ITALY. OI Ciardiello, Fortunato/0000-0002-3369-4841 NR 29 TC 16 Z9 16 U1 0 U2 0 PU STOCKTON PRESS PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS SN 0950-9232 J9 ONCOGENE JI Oncogene PD APR PY 1991 VL 6 IS 4 BP 583 EP 587 PG 5 WC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity SC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity GA FR939 UT WOS:A1991FR93900012 PM 1709483 ER PT J AU KOCHEL, T MUSHINSKI, JF RICE, NR AF KOCHEL, T MUSHINSKI, JF RICE, NR TI THE V-REL AND C-REL PROTEINS EXIST IN HIGH-MOLECULAR-WEIGHT COMPLEXES IN AVIAN AND MURINE CELLS SO ONCOGENE LA English DT Article ID NF-KAPPA-B; VIRUS-STRAIN-T; TRANSFORMED LYMPHOID-CELLS; DNA-BINDING SUBUNIT; BONE-MARROW CELLS; RETICULOENDOTHELIOSIS VIRUS; ONCOGENE PRODUCT; PROTOONCOGENE PRODUCT; TRANSCRIPTION FACTOR; HEMATOPOIETIC-CELLS AB We reported previously that the v-rel protein (p59v-rel) exists in a high molecular weight complex with at least four other proteins in the cytoplasm of v-rel-transformed chicken pre-B lymphoid cells (Simek, S. & Rice, N.R., J. Virol., 62, 4730-4736, 1989). One of these proteins is the chicken c-rel protein, but the identities of the others (of about 36 kDa, 115kDa, and 124 kDa) are unknown. In this report we extend that observation to additional v-rel-transformed cell lines of both pre-B and B cell phenotypes. We also introduced and expressed v-rel in several other avian cell lines (a chicken T cell line, chick embryo fibroblasts, and quail fibroblasts) and found that in these cells p59v-rel was complexed with the same proteins as observed in the v-rel-transformed cells. Thus, the associated proteins are not limited to pre-B cells, but occur and complex with p59v-rel in B cells, T cells, and fibroblasts. We next examined five uninfected avian cells and tissues and found that, with only one exception, p75c-rel was complexed with p36, p115, and p124. Thus, in most cases complex formation is not limited to or dependent on the presence of the transforming v-rel protein, but also occurs with the normal c-rel protein. To determine whether a mammalian c-rel protein is similarly associated with other proteins, we screened murine cell lines for the presence of c-rel mRNA. In agreement with our earlier findings, we found the highest expression in mature B cells, although several pre-B and myeloid cell lines were also strongly positive. Using one of the B cell lines, we detected the murine c-rel protein. We found that, like its avian counterpart, it is a protein of about 75 kDa and is associated with proteins of 36 kDa and 115 kDa. Sephacryl S-400 chromatography revealed that both the avian and murine complexes are of high molecular weight, with an average size of about 400 kDa. C1 NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,POB B,FREDERICK,MD 21701. NCI,GENET LAB,BETHESDA,MD 20892. FU NCI NIH HHS [N01-CO-74101] NR 51 TC 43 Z9 43 U1 0 U2 0 PU STOCKTON PRESS PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS SN 0950-9232 J9 ONCOGENE JI Oncogene PD APR PY 1991 VL 6 IS 4 BP 615 EP 626 PG 12 WC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity SC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity GA FR939 UT WOS:A1991FR93900017 PM 1851550 ER PT J AU BLAKE, TJ SHAPIRO, M MORSE, HC LANGDON, WY AF BLAKE, TJ SHAPIRO, M MORSE, HC LANGDON, WY TI THE SEQUENCES OF THE HUMAN AND MOUSE C-CBL PROTOONCOGENES SHOW V-CBL WAS GENERATED BY A LARGE TRUNCATION ENCOMPASSING A PROLINE-RICH DOMAIN AND A LEUCINE ZIPPER-LIKE MOTIF SO ONCOGENE LA English DT Article ID TRANSCRIPTION FACTORS; LYMPHOMAS AB The murine Cas NS-1 retrovirus carries the v-cbl oncogene and induces pre-B cell lymphomas and myeloid leukemias. The cellular homolog of v-cbl has been identified in mouse and human DNA, and was recently mapped to mouse chromosome 9 and human chromosome 11q23. To determine the coding sequences of the human and mouse c-cbl proto-oncogenes cDNA clones were isolated from libraries prepared from the human T cell leukemia lines CCRF-CEM and HUT 78, and the mouse pre-B cell line 70Z/3. DNA sequencing revealed an open reading frame encoding 906 amino acids in the human cDNAs and 896 amino acids in 70Z/3. The sequence showed that v-cbl is a markedly truncated form of murine c-cbl containing 355 N-terminal amino acids. The nucleotide sequence of v-cbl is identical to murine c-cbl in this region, and the human sequence has only five amino acid changes in the v-cbl portion. The most notable features of the sequence which was lost in the generation of v-cbl is a C-terminal leucine zipper and a stretch of 208 amino acids containing 23% proline and 19% serine/threonine residues. This proline-rich sequence has similarities to the transcriptional activation domains of some transcription factors, and v-cbl's transforming potential may be due to the loss of this region and the leucine zipper. C1 INST MED & VET SCI,DIV HUMAN IMMUNOL,ADELAIDE,SA 5000,AUSTRALIA. NIAID,IMMUNOPATHOL LAB,BETHESDA,MD 20892. OI Morse, Herbert/0000-0002-9331-3705 NR 17 TC 251 Z9 253 U1 0 U2 4 PU STOCKTON PRESS PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS SN 0950-9232 J9 ONCOGENE JI Oncogene PD APR PY 1991 VL 6 IS 4 BP 653 EP 657 PG 5 WC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity SC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity GA FR939 UT WOS:A1991FR93900022 PM 2030914 ER PT J AU SAAVEDRA, JE FARNSWORTH, DW AF SAAVEDRA, JE FARNSWORTH, DW TI BETA-KETONITROSAMINES AS SYNTHETIC EQUIVALENTS OF ALPHA-METHYLENE ALKANOLAMINO ANIONS SO ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL LA English DT Article ID REDUCTIVE ALKYLATION; SODIUM-BOROHYDRIDE; CARBONYL-COMPOUNDS; AMINO-ALCOHOLS; EPHEDRINE RP SAAVEDRA, JE (reprint author), NCI,FREDERICK CANC RES & DEV CTR,ABL,BASIC RES PROGRAM,FREDERICK,MD 21702, USA. NR 13 TC 0 Z9 0 U1 0 U2 0 PU ORGANIC PREP PROCEDURES INC PI NEWTON HIGHLANDS PA PO BOX 9, NEWTON HIGHLANDS, MA 02161 SN 0030-4948 J9 ORG PREP PROCED INT JI Org. Prep. Proced. Int. PD APR PY 1991 VL 23 IS 2 BP 139 EP 146 PG 8 WC Chemistry, Organic SC Chemistry GA FD560 UT WOS:A1991FD56000002 ER PT J AU MAX, MB KISHOREKUMAR, R SCHAFER, SC MEISTER, B GRACELY, RH SMOLLER, B DUBNER, R AF MAX, MB KISHOREKUMAR, R SCHAFER, SC MEISTER, B GRACELY, RH SMOLLER, B DUBNER, R TI EFFICACY OF DESIPRAMINE IN PAINFUL DIABETIC NEUROPATHY - A PLACEBO-CONTROLLED TRIAL SO PAIN LA English DT Article DE CONTROLLED CLINICAL TRIALS; ANTIDEPRESSANTS; ANALGESIA; PAIN; NOREPINEPHRINE ID POST-HERPETIC NEURALGIA; DOUBLE-BLIND CROSSOVER; POSTHERPETIC NEURALGIA; BACK-PAIN; AMITRIPTYLINE; MECHANISMS; ANTIDEPRESSANTS; NORTRIPTYLINE; CLONIDINE AB Although amitriptyline relieves pain in many patients with painful diabetic neuropathy, side effects often preclude effective treatment. Desipramine has the least anticholinergic and sedative effects of the first generation tricyclic antidepressants. We compared a 6 week course of desipramine (mean dose, 201 mg/day) to active placebo in 20 patients with painful diabetic neuropathy in a double-blind crossover trial. Pain relief with desipramine was statistically significant in weeks 5 and 6. Eleven patients reported at least moderate relief with desipramine, compared to 2 with placebo. Pain relief tended to be greater in depressed patients, but relief was also observed in patients who did not show an antidepressant effect. We conclude that desipramine relieves pain in many patients with painful diabetic neuropathy, offering an alternative for patients unable to tolerate amitriptyline. Blockade of norepinephrine reuptake, an action shared by desipramine, amitriptyline, and other antidepressants proven effective in neuropathic pain, may mediate this analgesic effect. C1 NIH,CLIN CTR NURSING DEPT,BETHESDA,MD 20892. VET ADM MED CTR,DEPT MED,DANVILLE,IL. RP MAX, MB (reprint author), NIDR,PAIN RES CLIN,NEUROBIOL & ANESTHESIOL BRANCH,BLDG 10,ROOM 3C-405,BETHESDA,MD 20892, USA. NR 36 TC 183 Z9 185 U1 3 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3959 J9 PAIN JI Pain PD APR PY 1991 VL 45 IS 1 BP 3 EP 9 DI 10.1016/0304-3959(91)90157-S PG 7 WC Anesthesiology; Clinical Neurology; Neurosciences SC Anesthesiology; Neurosciences & Neurology GA FJ993 UT WOS:A1991FJ99300002 PM 1861872 ER PT J AU BENNETT, GJ OCHOA, JL AF BENNETT, GJ OCHOA, JL TI THERMOGRAPHIC OBSERVATIONS ON RATS WITH EXPERIMENTAL NEUROPATHIC PAIN SO PAIN LA English DT Article DE CAUSALGIA; EXPERIMENTAL NEUROPATHY; NEUROPATHIC PAIN; NEUROPATHIC TEMPERATURE ABNORMALITY; REFLEX SYMPATHETIC DYSTROPHY; THERMOGRAPHY ID C-NOCICEPTORS; MECHANISMS; CAUSALGIA; HYPERALGESIA AB Infrared thermographic images were obtained from the plantar hind paws of rats with an experimental nerve injury that produces signs of neuropathic pain. Thermograms confirmed that the experimental neuropathy produces signs resembling those of patients with neuropathic pain. The hind paws on the nerve-damaged side were abnormally hot, abnormally cold, or apparently normal 8-16 days post injury, a variability that is seen clinically in neuropathic pain patients. Abnormally cold hind paws became warm as soon as the injured sciatic nerve was transected, indicating that the underlying vasoconstriction was mediated by neural impulse activity. Xylazine (Rompun), a sympatho-inhibitory alpha-2-adrenoceptor agonist that normally increases cutaneous temperature, caused the hind paw on the control side to warm, as anticipated, while causing paradoxical cooling of abnormally hot hind paws, and even of 'normal temperature' paws on the nerve-injured side. These findings shed light on possible mechanisms underlying abnormal deviations of skin temperature as a symptom of nerve injury. The findings also attest to the usefulness of the experimental animal model of neuropathic pain and of the thermographic method. C1 GOOD SAMARITAN HOSP,DEPT NEUROL,PORTLAND,OR 97210. OREGON HLTH SCI UNIV,PORTLAND,OR 97201. RP BENNETT, GJ (reprint author), NIDR,NEUROBIOL & ANESTHESIOL BRANCH,BLDG 30,ROOM B-20,BETHESDA,MD 20892, USA. FU NINDS NIH HHS [R01 NS 24740, R01 NS 24766] NR 38 TC 59 Z9 59 U1 2 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3959 J9 PAIN JI Pain PD APR PY 1991 VL 45 IS 1 BP 61 EP 67 DI 10.1016/0304-3959(91)90165-T PG 7 WC Anesthesiology; Clinical Neurology; Neurosciences SC Anesthesiology; Neurosciences & Neurology GA FJ993 UT WOS:A1991FJ99300010 PM 1861879 ER PT J AU HELMAN, LJ THIELE, CJ AF HELMAN, LJ THIELE, CJ TI NEW INSIGHTS INTO THE CAUSES OF CANCER SO PEDIATRIC CLINICS OF NORTH AMERICA LA English DT Review ID HUMAN NEURO-BLASTOMA; GROWTH FACTOR-II; THERAPEUTIC ANTICANCER AGENTS; BASEMENT-MEMBRANE COLLAGEN; BLADDER-CARCINOMA ONCOGENE; HUMAN RETINOBLASTOMA GENE; CELL-SURFACE RECEPTORS; C-MYC-GENE; N-MYC; METASTATIC PHENOTYPE RP HELMAN, LJ (reprint author), NCI,PEDIAT ONCOL BRANCH,MOLEC GENET SECT,9000 ROCKVILLE PIKE,BLDG 10,ROOM 13N240,BETHESDA,MD 20892, USA. NR 120 TC 6 Z9 6 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0031-3955 J9 PEDIATR CLIN N AM JI Pediatr. Clin. N. Am. PD APR PY 1991 VL 38 IS 2 BP 201 EP 221 PG 21 WC Pediatrics SC Pediatrics GA GC734 UT WOS:A1991GC73400002 PM 2006074 ER PT J AU BERG, SL GRISELL, DL DELANEY, TF BALIS, FM AF BERG, SL GRISELL, DL DELANEY, TF BALIS, FM TI PRINCIPLES OF TREATMENT OF PEDIATRIC SOLID TUMORS SO PEDIATRIC CLINICS OF NORTH AMERICA LA English DT Article ID CONGESTIVE HEART-FAILURE; MULTIDRUG-RESISTANCE; CLINICAL PHARMACOKINETICS; RADIATION-THERAPY; CANCER-CHEMOTHERAPY; ANTICANCER DRUGS; BREAST-CANCER; ADRIAMYCIN; CELLS; CARDIOTOXICITY C1 NCI,RADIAT ONCOL BRANCH,BETHESDA,MD 20892. RP BERG, SL (reprint author), NCI,PEDIAT BRANCH,BLDG 10,ROOM 13N240,BETHESDA,MD 20892, USA. NR 67 TC 5 Z9 6 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0031-3955 J9 PEDIATR CLIN N AM JI Pediatr. Clin. N. Am. PD APR PY 1991 VL 38 IS 2 BP 249 EP 267 PG 19 WC Pediatrics SC Pediatrics GA GC734 UT WOS:A1991GC73400004 PM 2006077 ER PT J AU GOOTENBERG, JE PIZZO, PA AF GOOTENBERG, JE PIZZO, PA TI OPTIMAL MANAGEMENT OF ACUTE TOXICITIES OF THERAPY SO PEDIATRIC CLINICS OF NORTH AMERICA LA English DT Review ID COLONY-STIMULATING FACTOR; BONE-MARROW TRANSPLANTATION; PROPHYLACTIC GRANULOCYTE TRANSFUSIONS; HEMATOPOIETIC GROWTH-FACTORS; NEUTROPENIC CANCER-PATIENTS; TOTAL PARENTERAL-NUTRITION; EMPIRIC ANTIBIOTIC-THERAPY; ACUTE MYELOGENOUS LEUKEMIA; CHEMOTHERAPY-INDUCED MYELOSUPPRESSION; ACQUIRED IMMUNODEFICIENCY SYNDROME C1 NCI,INFECT DIS SECT,BETHESDA,MD 20892. RP GOOTENBERG, JE (reprint author), GEORGETOWN UNIV,VINCENT T LOMBARDI CANC RES CTR,DEPT PEDIAT,WASHINGTON,DC 20007, USA. NR 232 TC 4 Z9 4 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0031-3955 J9 PEDIATR CLIN N AM JI Pediatr. Clin. N. Am. PD APR PY 1991 VL 38 IS 2 BP 269 EP 297 PG 29 WC Pediatrics SC Pediatrics GA GC734 UT WOS:A1991GC73400005 PM 2006078 ER PT J AU HOROWITZ, ME NEFF, JR KUN, LE AF HOROWITZ, ME NEFF, JR KUN, LE TI EWING SARCOMA - RADIOTHERAPY VERSUS SURGERY FOR LOCAL-CONTROL SO PEDIATRIC CLINICS OF NORTH AMERICA LA English DT Article ID COMBINATION CHEMOTHERAPY; MULTIMODAL THERAPY; RADIATION-THERAPY; BONE; EXPERIENCE; MANAGEMENT; CHILDREN; PATTERNS; TUMORS; CELL C1 UNIV KANSAS, MED CTR, SCH MED, DEPT ORTHOPED SURG, KANSAS CITY, KS 66103 USA. ST JUDE CHILDRENS RES HOSP, DEPT RADIAT ONCOL, MEMPHIS, TN 38101 USA. UNIV TENNESSEE, CTR HLTH SCI, COLL MED, RADIAT ONCOL SECT, MEMPHIS, TN 38163 USA. RP HOROWITZ, ME (reprint author), NCI, PEDIAT BRANCH, BLDG 10, ROOM 13N240, BETHESDA, MD 20892 USA. NR 40 TC 11 Z9 11 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0031-3955 J9 PEDIATR CLIN N AM JI Pediatr. Clin. N. Am. PD APR PY 1991 VL 38 IS 2 BP 365 EP 380 PG 16 WC Pediatrics SC Pediatrics GA GC734 UT WOS:A1991GC73400009 PM 2006082 ER PT J AU FRIEDMAN, HS HOROWITZ, M OAKES, WJ AF FRIEDMAN, HS HOROWITZ, M OAKES, WJ TI TUMORS OF THE CENTRAL-NERVOUS-SYSTEM - IMPROVEMENT IN OUTCOME THROUGH A MULTIMODALITY APPROACH SO PEDIATRIC CLINICS OF NORTH AMERICA LA English DT Article ID PRIMITIVE NEUROECTODERMAL TUMORS; MEDULLOBLASTOMA CELL-LINE; BRAIN-TUMORS; POSTOPERATIVE CHEMOTHERAPY; ADJUVANT CHEMOTHERAPY; RADIATION-THERAPY; RANDOMIZED TRIAL; C-MYC; CHILDREN; AMPLIFICATION C1 NCI,PEDIAT BRANCH,BETHESDA,MD 20892. DUKE UNIV,MED CTR,DEPT SURG & PEDIAT,DIV NEUROSURG,DURHAM,NC 27710. RP FRIEDMAN, HS (reprint author), DUKE UNIV,MED CTR,DEPT PEDIAT,DIV HEMATOL ONCOL,ERWIN RD,DURHAM,NC 27710, USA. NR 43 TC 5 Z9 6 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0031-3955 J9 PEDIATR CLIN N AM JI Pediatr. Clin. N. Am. PD APR PY 1991 VL 38 IS 2 BP 381 EP 391 PG 11 WC Pediatrics SC Pediatrics GA GC734 UT WOS:A1991GC73400010 PM 2006083 ER PT J AU ADAMSON, PC HOROWITZ, ME POPLACK, DG AF ADAMSON, PC HOROWITZ, ME POPLACK, DG TI THE CHILD WITH RECURRENT SOLID TUMOR SO PEDIATRIC CLINICS OF NORTH AMERICA LA English DT Article ID SOFT-TISSUE SARCOMAS; PULMONARY METASTASES; OSTEOGENIC-SARCOMA; PROGNOSTIC-SIGNIFICANCE; MULTIDRUG-RESISTANCE; EWINGS-SARCOMA; RESECTION; SURVIVAL; CANCER; THORACOTOMY C1 NCI,PEDIAT BRANCH,LEUKEMIA BIOL SECT,BETHESDA,MD 20892. RP ADAMSON, PC (reprint author), NCI,PEDIAT BRANCH,BLDG 10,ROOM 13N240,BETHESDA,MD 20892, USA. NR 47 TC 3 Z9 3 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0031-3955 J9 PEDIATR CLIN N AM JI Pediatr. Clin. N. Am. PD APR PY 1991 VL 38 IS 2 BP 489 EP 504 PG 16 WC Pediatrics SC Pediatrics GA GC734 UT WOS:A1991GC73400016 PM 2006087 ER PT J AU HOROWITZ, ME PIZZO, PA AF HOROWITZ, ME PIZZO, PA TI SOLID TUMORS IN CHILDREN - PREFACE SO PEDIATRIC CLINICS OF NORTH AMERICA LA English DT Editorial Material RP HOROWITZ, ME (reprint author), NCI,PEDIAT BRANCH,9000 ROCKVILLE PIKE,BETHESDA,MD 20892, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0031-3955 J9 PEDIATR CLIN N AM JI Pediatr. Clin. N. Am. PD APR PY 1991 VL 38 IS 2 BP R15 EP R16 PG 2 WC Pediatrics SC Pediatrics GA GC734 UT WOS:A1991GC73400001 ER PT J AU ROILIDES, E MUELLER, BU LETTERIO, JJ BUTLER, K PIZZO, PA AF ROILIDES, E MUELLER, BU LETTERIO, JJ BUTLER, K PIZZO, PA TI AGROBACTERIUM-RADIOBACTER BACTEREMIA IN A CHILD WITH HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Note DE AGROBACTERIUM-RADIOBACTER; BACTEREMIA; HIV-1 INFECTION ID IMMUNE-DEFICIENCY SYNDROME; SEPTICEMIA; CATHETER C1 NCI,PEDIAT ONCOL BRANCH,INFECT DIS SECT,BLDG 10,RM 13N240,BETHESDA,MD 20892. NR 16 TC 20 Z9 21 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD APR PY 1991 VL 10 IS 4 BP 337 EP 338 DI 10.1097/00006454-199104000-00016 PG 2 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA FF988 UT WOS:A1991FF98800016 PM 2062633 ER PT J AU BOCK, GH ONGKINGCO, JR PATTERSON, LT RULEY, J NELSON, DL AF BOCK, GH ONGKINGCO, JR PATTERSON, LT RULEY, J NELSON, DL TI SOLUBLE INTERLEUKIN-2 RECEPTOR (SIL-2R) EXCRETION IN NORMAL PROTEINURIC AND IDIOPATHIC NEPHROTIC SYNDROME (INS) PATIENTS SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 NCI,BETHESDA,MD 20892. CHILDRENS NATL MED CTR,DEPT NEPHROL,WASHINGTON,DC. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A339 EP A339 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03802011 ER PT J AU CHEN, YT BAZZARRE, C LEE, M SIDBURY, JB COLEMAN, RA AF CHEN, YT BAZZARRE, C LEE, M SIDBURY, JB COLEMAN, RA TI TYPE-I GLYCOGEN-STORAGE-DISEASE - 9 YEARS OF MANAGEMENT WITH CORNSTARCH SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 DUKE UNIV,MED CTR,DEPT PEDIAT,DURHAM,NC 27710. NICHHD,HUMAN GENET BRANCH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A191 EP A191 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03801127 ER PT J AU CHUNDU, KR SIMPSON, IA AF CHUNDU, KR SIMPSON, IA TI DEVELOPMENTAL REGULATION OF FACILITATIVE GLUCOSE TRANSPORTER PROTEINS IN RAT SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 NIDDK,BETHESDA,MD. CHILDRENS NATL MED CTR,DIV CRIT CARE MED,WASHINGTON,DC. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A39 EP A39 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03800217 ER PT J AU CHUNDU, KR SIMPSON, IA AF CHUNDU, KR SIMPSON, IA TI ALTERATIONS OF GLUCOSE TRANSPORTER PROTEIN EXPRESSION IN CYANOTIC MYOCARDIUM SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 CHILDRENS NAT MED CTR,DIV CRITICAL CARE MED,WASHINGTON,DC. NIDDK,BETHESDA,MD. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A16 EP A16 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03800083 ER PT J AU COOPER, MJ STEINBERG, SM EVANS, AE CHATTEN, J ISRAEL, MA AF COOPER, MJ STEINBERG, SM EVANS, AE CHATTEN, J ISRAEL, MA TI MOLECULAR ANALYSIS OF NEUROBLASTOMA (NB) SUGGESTS A BIOLOGIC CONTEXT FOR IMPROVED PATIENT SURVIVAL SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 UNIV HOSP CLEVELAND,DIV HEMATOL ONCOL,CLEVELAND,OH 44106. NCI,BETHESDA,MD 20892. CHILDRENS HOSP,PHILADELPHIA,PA 19104. UNIV CALIF SAN FRANCISCO,DEPT NEUROSURG,SAN FRANCISCO,CA 94143. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A138 EP A138 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03800807 ER PT J AU EPPS, RP MANLEY, MW AF EPPS, RP MANLEY, MW TI CLINICAL INTERVENTIONS TO PREVENT TOBACCO USE DURING CHILDHOOD AND ADOLESCENCE SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 NCI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A90 EP A90 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03800522 ER PT J AU HAMOSH, A TRAPNELL, BC MONTROSERAFIZADEH, C ZEITLIN, PL ROSENSTEIN, BJ CRYSTAL, RG CUTTING, GR AF HAMOSH, A TRAPNELL, BC MONTROSERAFIZADEH, C ZEITLIN, PL ROSENSTEIN, BJ CRYSTAL, RG CUTTING, GR TI CFTR MESSENGER-RNA TRANSCRIPTS ARE DECREASED IN RESPIRATORY EPITHELIA OF PATIENTS WITH NONSENSE MUTATIONS IN THE CYSTIC-FIBROSIS GENE SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 JOHNS HOPKINS UNIV,SCH MED,DEPT PEDIAT,BALTIMORE,MD 21205. NHLBI,PULM BRANCH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 1 U2 3 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A130 EP A130 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03800760 ER PT J AU HILLMAN, LS VIERA, NE JOHNSON, LS YERGY, AL AF HILLMAN, LS VIERA, NE JOHNSON, LS YERGY, AL TI CALCIUM PERCENT TRUE ABSORPTION ALPHA, 24 HR. ENDOGENOUS FECAL EXCRETION (VF), 24 HR. URINARY-EXCRETION (VU) AND PERCENT RETENTION (R) USING CA-46 AND CA-44 IN PREMATURE-INFANTS SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 UNIV MISSOURI,DEPT CHILD HLTH,COLUMBIA,MO 65201. NIH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A296 EP A296 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03801756 ER PT J AU HOFFMAN, HJ MALLOY, M PETERSON, D AF HOFFMAN, HJ MALLOY, M PETERSON, D TI CIGARETTE-SMOKING AND SUDDEN-INFANT-DEATH-SYNDROME (SIDS) - NO DOSE-RESPONSE IN DATA FROM THE UNITED-STATES SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 NICHHD,PREVENT RES,BETHESDA,MD. UNIV WASHINGTON,SCH PUBL HLTH,SEATTLE,WA 98195. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A91 EP A91 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03800530 ER PT J AU JOHNSON, EO DECKER, L KAMILARIS, TC REDWINE, J GOLD, PP CHROUSOS, GP AF JOHNSON, EO DECKER, L KAMILARIS, TC REDWINE, J GOLD, PP CHROUSOS, GP TI TYPE-I AND TYPE-II GLUCOCORTICOID RECEPTOR MESSENGER-RNA IN THE PRIMATE HIPPOCAMPUS SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 NICHHD,DEV ENDOCRINOL BRANCH,BETHESDA,MD 20892. NIMH,CLIN NEUROSCI BRANCH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A79 EP A79 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03800459 ER PT J AU KALER, SG MARAIA, RJ GAHL, WA AF KALER, SG MARAIA, RJ GAHL, WA TI A NOVEL 23KD COPPER-BINDING PROTEIN OF HUMAN FIBROBLASTS AND LIVER IDENTIFIED BY A COPPER BLOTTING TECHNIQUE SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 NICHHD,BETHESDA,MD 20892. NR 0 TC 1 Z9 1 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A194 EP A194 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03801146 ER PT J AU KALER, SG GOLDSTEIN, DS HOLMES, C HAHN, SH GAHL, WA AF KALER, SG GOLDSTEIN, DS HOLMES, C HAHN, SH GAHL, WA TI PLASMA AND CSF CATECHOLAMINE LEVELS IN MENKES DISEASE SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 NICHHD,HUMAN GENET BRANCH,BETHESDA,MD 20892. NINCDS,CLIN NEUROSCI BRANCH,BETHESDA,MD 20892. NR 0 TC 1 Z9 1 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A194 EP A194 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03801145 ER PT J AU KARALIS, K SANO, H WILDER, R STERNBERG, E GOLD, P CHROUSOS, GP AF KARALIS, K SANO, H WILDER, R STERNBERG, E GOLD, P CHROUSOS, GP TI INFLAMMATORY DISEASE SUSCEPTIBLE LEWIS RATS - EVIDENCE FOR CENTRAL DEFICIENCY BUT PERIPHERAL EXCESS OF CRH SYNTHESIS SECRETION SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 NICHHD,DEV ENDOCRINOL BRANCH,BETHESDA,MD 20892. NIAMS,BETHESDA,MD. NIMH,BETHESDA,MD 20892. NR 0 TC 3 Z9 3 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A80 EP A80 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03800462 ER PT J AU KARPATI, RM HODES, RJ AF KARPATI, RM HODES, RJ TI ALTERATIONS IN THE PHYSICAL ASSOCIATION OF IL2R SUBUNITS IN MURINE T-HELPER CLONES ACTIVATED WITH ANTI-CD3 AS COMPARED TO IL2 SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 NIH,NCI,EXPTL IMMUNOL BRANCH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A159 EP A159 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03800932 ER PT J AU KATKIN, JP MALECH, HL MURPHY, PM LETO, TL AF KATKIN, JP MALECH, HL MURPHY, PM LETO, TL TI RECOMBINANT PHAGOCYTE CYTOCHROME B558 IN A BACULOVIRUS SYSTEM SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 NIAID,BACTERIAL DIS SECT,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A131 EP A131 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03800765 ER PT J AU KATONA, IM URBAN, JF PAUL, WE FINKELMAN, FD AF KATONA, IM URBAN, JF PAUL, WE FINKELMAN, FD TI INVIVO REGULATION OF THE SECONDARY IGE RESPONSES BY IL-4 SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. USDA,BETHESDA,MD. NIH,BELTSVILLE,MD. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A159 EP A159 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03800934 ER PT J AU KLEBANOFF, MA REGAN, JA NUGENT, RP AF KLEBANOFF, MA REGAN, JA NUGENT, RP TI MATERNAL GROUP-B STREPTOCOCCAL (GBS) COLONIZATION AND PREGNANCY OUTCOME SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 NICHHD,BETHESDA,MD 20892. COLUMBIA UNIV,BABIES HOSP,DEPT PEDIAT,NEW YORK,NY 10027. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A258 EP A258 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03801529 ER PT J AU KLEBANOFF, MA AF KLEBANOFF, MA TI PATERNAL AND MATERNAL BIRTH WEIGHTS AND SUBSEQUENT PREGNANCY OUTCOME SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 NICHHD,BETHESDA,MD. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A92 EP A92 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03800538 ER PT J AU KOLOBOW, T MULLER, E MANDAVA, S JONES, M VITALE, G APRIGLIANO, M YAMADA, K AF KOLOBOW, T MULLER, E MANDAVA, S JONES, M VITALE, G APRIGLIANO, M YAMADA, K TI INTRATRACHEAL PULMONARY VENTILATION (ITPV) - A NEW TECHNIQUE SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 NHLBI,LCB,BETHESDA,MD 20892. NR 0 TC 3 Z9 3 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A31 EP A31 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03800168 ER PT J AU LAUE, L JONES, J BARNES, K CUTLER, GB AF LAUE, L JONES, J BARNES, K CUTLER, GB TI LONG-TERM TREATMENT OF FAMILIAL MALE PRECOCIOUS PUBERTY (FMPP) SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 GEORGETOWN UNIV,DEPT PEDIAT,WASHINGTON,DC 20057. NICHHD,DEV ENDOCRINOL BRANCH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A80 EP A80 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03800467 ER PT J AU LERNER, A HADEN, ST DEAN, M LEBENTHAL, E HOLSCLAW, DS KRUEGER, LJ AF LERNER, A HADEN, ST DEAN, M LEBENTHAL, E HOLSCLAW, DS KRUEGER, LJ TI 2 PARAMETER GENOTYPING BY ACRYLAMIDE-GEL ELECTROPHORESIS - ANALYSIS OF THE MOST COMMON MUTATION (DF508) IN CYSTIC-FIBROSIS SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 HAHNEMANN UNIV,DEPT PEDIAT,PHILADELPHIA,PA 19102. NCI,FREDERICK CANC RES FACIL,BIOL CARCINOGENESIS PROGRAM,FREDERICK,MD 21701. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A132 EP A132 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03800773 ER PT J AU MALLOY, M ONSTAD, L HACK, M WRIGHT, L HAWES, S WRIGHT, E AF MALLOY, M ONSTAD, L HACK, M WRIGHT, L HAWES, S WRIGHT, E TI FACTORS ASSOCIATED WITH AUTOPSY RATES IN A POPULATION OF VERY-LOW-BIRTH-WEIGHT INFANTS (VLBW) SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 NICHHD,NEONATAL RES NETWORK,BETHESDA,MD. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A225 EP A225 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03801328 ER PT J AU MALLOY, M HOFFMAN, H AF MALLOY, M HOFFMAN, H TI GESTATIONAL-AGE (GA) MISCLASSIFICATION IN VITAL STATISTIC DATA - EFFECT ON INFANT-MORTALITY RATES (IMR) SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 NICH,BETHESDA,MD. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A92 EP A92 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03800539 ER PT J AU MCCUNE, SK VOIGT, MM HILL, JM AF MCCUNE, SK VOIGT, MM HILL, JM TI REGIONAL BRAIN DISTRIBUTION OF MULTIPLE ALPHA ADRENERGIC-RECEPTOR SUBTYPES DURING DEVELOPMENT SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 NICHHD,DEV NEUROBIOL LAB,BETHESDA,MD 20892. CHILDRENS NATL MED CTR,DEPT PEDIAT MED,WASHINGTON,DC. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A47 EP A47 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03800266 ER PT J AU MILLS, JL TUOMILEHTO, J YU, KF RUNDLE, W BLANER, W KOSKELLA, P COLMAN, N FORMAN, M TOIVANEN, L RHOADS, GG AF MILLS, JL TUOMILEHTO, J YU, KF RUNDLE, W BLANER, W KOSKELLA, P COLMAN, N FORMAN, M TOIVANEN, L RHOADS, GG TI MATERNAL VITAMIN LEVELS DURING PREGNANCIES PRODUCING INFANTS WITH NEURAL-TUBE DEFECTS SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 NICHD FINLAND NEURAL TUBE DEFECTS STUDY,BETHESDA,MD. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A71 EP A71 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03800408 ER PT J AU MOFENSON, L NUGENT, R RIGAUPEREZ, J AF MOFENSON, L NUGENT, R RIGAUPEREZ, J TI SERIOUS BACTERIAL-INFECTIONS IN HIV-INFECTED CHILDREN IN A CLINICAL-TRIAL OF INTRAVENOUS IMMUNOGLOBULIN SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 NICHHD,DRP,PAMA,BETHESDA,MD 20892. NR 0 TC 1 Z9 1 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A179 EP A179 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03801053 ER PT J AU MOFENSON, LM AF MOFENSON, LM TI INTRAVENOUS IMMUNOGLOBULIN (IG) REDUCES NUMBER OF SERIOUS BACTERIAL-INFECTIONS (SBI) IN SYMPTOMATIC HIV-INFECTED CHILDREN SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 NICHHD,PEDIAT ADOLESCENT & MATERNAL AIDS BRANCH,BETHESDA,MD 20892. NICHHD,NICHO IVIG CLIN TRIAL STUDY GRP,BETHESDA,MD 20892. NR 0 TC 1 Z9 1 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A179 EP A179 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03801054 ER PT J AU MULLER, E KOLOBOW, T MANDAVA, S JONES, M VITALE, G APRIGLIANO, M YAMADA, K AF MULLER, E KOLOBOW, T MANDAVA, S JONES, M VITALE, G APRIGLIANO, M YAMADA, K TI INTRATRACHEAL PULMONARY VENTILATION (ITPV) - A NEW TECHNIQUE TO VENTILATE LUNGS AS SMALL AS 12-PERCENT OF NORMAL SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 NHLBI,LCB,SPCAD,BETHESDA,MD 20892. NR 0 TC 5 Z9 5 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A326 EP A326 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03801934 ER PT J AU MUNICCHI, G ROSE, SR BARNES, KM CASSORLA, F CUTLER, GB AF MUNICCHI, G ROSE, SR BARNES, KM CASSORLA, F CUTLER, GB TI A DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF LHRH AGONIST (LHRHA) TREATMENT IN PATIENTS WITH SHORT STATURE AND NORMAL ONSET OF PUBERTY - PRELIMINARY-RESULTS SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 NICHHD,DEV ENDOCRINOL BRANCH,BETHESDA,MD 20892. NR 0 TC 4 Z9 4 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A82 EP A82 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03800479 ER PT J AU OERTER, KE SOBEL, A ROSE, SR CHRISTIANO, A MALLEY, JD CUTLER, GB BARON, J AF OERTER, KE SOBEL, A ROSE, SR CHRISTIANO, A MALLEY, JD CUTLER, GB BARON, J TI IMPROVED DIAGNOSIS OF GROWTH-HORMONE DEFICIENCY BY COMBINING IGF-1 LEVELS WITH SPONTANEOUS MEAN NIGHTTIME GROWTH-HORMONE LEVELS SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 NIH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A83 EP A83 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03800483 ER PT J AU RADOVICK, S TICKNOR, CM NAKAYAMA, Y RAHMAN, A CUTLER, GB WONDISFORD, FE AF RADOVICK, S TICKNOR, CM NAKAYAMA, Y RAHMAN, A CUTLER, GB WONDISFORD, FE TI EVIDENCE FOR DIRECT ESTROGEN REGULATION OF THE HUMAN GONADOTROPIN-RELEASING-HORMONE GENE SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 CASE WESTERN RESERVE UNIV,SCH MED,CLEVELAND,OH 44106. NIH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A84 EP A84 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03800489 ER PT J AU RAY, PE KLOTMAN, PE AF RAY, PE KLOTMAN, PE TI EFFECTS OF POTASSIUM-DEPLETION ON ANGIOTENSIN-II (AII) STIMULATED MITOGENESIS OF HUMAN FETAL MESANGIAL CELLS (HFMC) SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 NIDR,LDBA,WASHINGTON,DC. CHILDRENS NATL MED CTR,WASHINGTON,DC. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A349 EP A349 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03802075 ER PT J AU RAY, PE RULEY, EJ AF RAY, PE RULEY, EJ TI DIFFERENT EFFECTS OF CHRONIC POTASSIUM-DEPLETION ON CENTRAL AND PERIPHERAL ANGIOTENSIN-II RECEPTORS IN YOUNG-RATS SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 CHILDRENS NATL MED CTR,WASHINGTON,DC. NIMH,LCS,PHARMACOL SECT,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A349 EP A349 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03802076 ER PT J AU REVENIS, ME KALINER, MA AF REVENIS, ME KALINER, MA TI ASSOCIATION OF TRACHEAL ASPIRATE (TA) LYSOZYME (L) LEVELS WITH SEVERITY OF BRONCHOPULMONARY DYSPLASIA (BPD) SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 NIAID,BETHESDA,MD 20892. GEORGE WASHINGTON UNIV,SCH MED & HLTH SCI,CHILDRENS NATL MED CTR,DEPT NEONATOL,WASHINGTON,DC 20052. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A327 EP A327 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03801944 ER PT J AU ROSS, JL LONG, LM MARIN, G ROSE, S CUTLER, GB AF ROSS, JL LONG, LM MARIN, G ROSE, S CUTLER, GB TI BONE-MINERAL CONTENT OF THE WRIST AND SPINE IN NORMAL GIRLS AND BOYS SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 MED COLL PENN,DEPT PEDIAT,PHILADELPHIA,PA 19129. NIH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A85 EP A85 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03800493 ER PT J AU RUTTIMANN, UE POLLACK, MM AF RUTTIMANN, UE POLLACK, MM TI IMPROVED OUTCOME PREDICTIONS USING TIME-SERIES ANALYSIS SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 NIMH,INST DENT,BETHESDA,MD 20892. GEORGE WASHINGTON UNIV,SCH MED,CHILDRENS HOSP,NATL MED CTR,DEPT CRIT CARE,WASHINGTON,DC 20052. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A33 EP A33 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03800181 ER PT J AU SHANKARAN, S BAUER, C BANDSTRA, E POLAND, R EDWARDS, W ONSTAD, L WRIGHT, E MALLOY, M WRIGHT, L AF SHANKARAN, S BAUER, C BANDSTRA, E POLAND, R EDWARDS, W ONSTAD, L WRIGHT, E MALLOY, M WRIGHT, L TI INTRACRANIAL HEMORRHAGE (ICH) IN 2928 LESS-THAN-1500 G NEONATES SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 NICHHD,NEONATAL RES NETWORK,BETHESDA,MD. NR 0 TC 5 Z9 5 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A266 EP A266 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03801573 ER PT J AU SHOEMAKER, LR WELCH, TR BERGSTROM, W YERGEY, AL ABRAMS, SA VIEIRA, NE AF SHOEMAKER, LR WELCH, TR BERGSTROM, W YERGEY, AL ABRAMS, SA VIEIRA, NE TI CALCIUM-METABOLISM IN HYPERCALCIURIC BARTTERS-SYNDROME (HBS) - STUDIES WITH STABLE CA ISOTOPES SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 CHILDRENS HOSP,CINCINNATI,OH. SUNY SYRACUSE,SYRACUSE,NY. NIH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A351 EP A351 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03802088 ER PT J AU SPENCER, CH LEHMAN, T PETERMAN, G HIRSCH, R AF SPENCER, CH LEHMAN, T PETERMAN, G HIRSCH, R TI PREVENTION OF-2 MURINE AUTOIMMUNE-DISEASES BY ANTI-CD3 IMMUNOTHERAPY SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 LA RABIDA CHILDRENS HOSP & RES CTR,CHICAGO,IL. HOSP SPECIAL SURG,NEW YORK,NY 10021. PFIZER INC,GROTON,CA. NCI,EXPTL IMMUNOL BRANCH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A164 EP A164 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03800963 ER PT J AU SWEDO, SE KILPATRICK, K SCHAPIRO, M MANNHEIM, G LEONARD, H AF SWEDO, SE KILPATRICK, K SCHAPIRO, M MANNHEIM, G LEONARD, H TI ANTINEURONAL ANTIBODIES (ANA) IN SYDENHAM CHOREA (SC) AND OBSESSIVE-COMPULSIVE DISORDER (OCD) SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 NIH,BETHESDA,MD 20892. NR 0 TC 16 Z9 16 U1 0 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A364 EP A364 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03802162 ER PT J AU TYSON, J WRIGHT, E MALLOY, M WRIGHT, L AF TYSON, J WRIGHT, E MALLOY, M WRIGHT, L TI HOW PREDICTABLE IS THE OUTCOME AND CARE OF VENTILATED EXTREME LOW-BIRTH-WEIGHT (ELBW - GREATER-THAN 1000 G) INFANTS SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 NICHHD,NEONATAL RES NETWORK,BETHESDA,MD 20892. NR 0 TC 4 Z9 4 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A237 EP A237 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03801404 ER PT J AU VETTER, U FEDARKO, NS YOUNG, MF TERMINE, JD JUST, W VOGEL, W ROBEY, PG AF VETTER, U FEDARKO, NS YOUNG, MF TERMINE, JD JUST, W VOGEL, W ROBEY, PG TI BIGLYCAN SYNTHESIS IN FIBROBLASTS OF PATIENTS WITH TURNER SYNDROME AND OTHER X-CHROMOSOME ABNORMALITIES SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 NIDR,BRB,BETHESDA,MD 20892. UNIV ULM,KLIN GENET ABT,W-7900 ULM,GERMANY. RI Robey, Pamela/H-1429-2011 OI Robey, Pamela/0000-0002-5316-5576 NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A135 EP A135 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03800791 ER PT J AU WAISMAN, Y EICHACKER, PQ RICHMOND, S BANKS, SM HOFFMAN, WD MACVITTIE, T NATANSON, C AF WAISMAN, Y EICHACKER, PQ RICHMOND, S BANKS, SM HOFFMAN, WD MACVITTIE, T NATANSON, C TI ARTERIAL BASE DEFICIT PREDICTS VOLUME LOSS IN CANINE HEMORRHAGE SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 NIH,DEPT CRIT CARE MED,BETHESDA,MD 20892. GEORGE WASHINGTON UNIV,CHILDRENS NATL MED CTR,CTR EMERGENCY MED TRAUMA,WASHINGTON,DC 20052. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A35 EP A35 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03800194 ER PT J AU WISWELL, TE CURTIS, J DOBEK, AS ZIERDT, CH AF WISWELL, TE CURTIS, J DOBEK, AS ZIERDT, CH TI STAPHYLOCOCCAL-AUREUS COLONIZATION FOLLOWING NEONATAL CIRCUMCISION - IS THERE DEVICE DEPENDENCY SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NIH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A126 EP A126 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03800734 ER PT J AU MCCRAE, RR COSTA, PT AF MCCRAE, RR COSTA, PT TI ADDING LIEBE UND ARBEIT - THE FULL 5-FACTOR MODEL AND WELL-BEING SO PERSONALITY AND SOCIAL PSYCHOLOGY BULLETIN LA English DT Article ID NEGATIVE AFFECT; LIFE EVENTS; PERSONALITY; MOOD; EXTRAVERSION; INDEPENDENCE; NEUROTICISM; SAMPLE; HEALTH RP MCCRAE, RR (reprint author), NIA,GERONTOL RES CTR,4940 EASTERN AVE,BALTIMORE,MD 21224, USA. RI Vollrath, Margarete/G-1297-2011 NR 39 TC 409 Z9 430 U1 5 U2 26 PU SAGE SCIENCE PRESS PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 SN 0146-1672 J9 PERS SOC PSYCHOL B JI Pers. Soc. Psychol. Bull. PD APR PY 1991 VL 17 IS 2 BP 227 EP 232 DI 10.1177/014616729101700217 PG 6 WC Psychology, Social SC Psychology GA FF728 UT WOS:A1991FF72800016 ER PT J AU MITCHELL, CL BARNES, MI HUDSON, PM HONG, JS AF MITCHELL, CL BARNES, MI HUDSON, PM HONG, JS TI OPIOID MU AND DELTA RECEPTOR ANTAGONISTS REDUCE WET DOG SHAKING ELICITED BY PERFORANT PATH STIMULATION SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR LA English DT Article DE HIPPOCAMPUS; OPIOID PEPTIDES; OPIOID ANTAGONISTS; WET DOG SHAKES; GABA; PERFORANT PATH ID DENTATE GRANULE CELLS; KAINIC ACID; RAT HIPPOCAMPUS; INDUCED SEIZURES; SHAKES; PEPTIDES; AGONIST AB Stimulation of the perforant path, a major input to the hippocampal formation, produced significant decreases in the hippocampal levels of methionine enkephalin, dynorphin A(1-8) and an increase in the hippocampal level of gamma-aminobutyric acid. In addition, it was also observed that both mu and delta opioid receptor antagonists reduce wet dog shakes elicited by perforant path stimulation. The antagonists did not affect the changes in hippocampal levels of methionine enkephalin, dynorphin A(1-8) or gamma-aminobutyric acid. The results demonstrate that endogenous opioids are involved in the wet dog shakes elicited by perforant path stimulation. Since electrographic seizure activity occurs in the hippocampus in conjunction with perforant path stimulation-induced wet dog shakes, these data provide further evidence that endogenous opioid peptides play an important role in regulation of limbic system epileptogenic phenomena. RP MITCHELL, CL (reprint author), NIEHS,MOLEC & INTEGRAT NEUROSCI LAB,POB 12233,MD 17-01,RES TRIANGLE PK,NC 27709, USA. NR 26 TC 4 Z9 4 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0091-3057 J9 PHARMACOL BIOCHEM BE JI Pharmacol. Biochem. Behav. PD APR PY 1991 VL 38 IS 4 BP 801 EP 805 DI 10.1016/0091-3057(91)90245-W PG 5 WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy GA FJ069 UT WOS:A1991FJ06900017 PM 1678526 ER PT J AU TANDON, P MUNDY, WR ALI, SF NANRY, K ROGERS, BC TILSON, HA AF TANDON, P MUNDY, WR ALI, SF NANRY, K ROGERS, BC TILSON, HA TI AGE-DEPENDENT CHANGES IN RECEPTOR-STIMULATED PHOSPHOINOSITIDE TURNOVER IN THE RAT HIPPOCAMPUS SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR LA English DT Article DE AGING; PHOSPHOINOSITIDE TURNOVER; HIPPOCAMPUS; CHOLINE ACETYLTRANSFERASE; CHOLINERGIC MUSCARINIC BINDING ID BRAIN MUSCARINIC RECEPTORS; CHOLINE-ACETYLTRANSFERASE; SPATIAL MEMORY; ANIMAL-MODELS; HYDROLYSIS; PHOSPHATIDYLINOSITOL; AGONIST; BINDING; NEUROTRANSMISSION; PHOSPHOLIPIDS AB To study the changes in the hippocampal cholinergic system of chronologically old and behaviorally impaired animals, old (21 months of age) and young (3 months of age) male, Fischer-344 rats were used. The aged animals were tested on a reference memory task (Morris water maze) and found to be functionally impaired as compared to the young controls. Carbachol-stimulated phosphoinositide metabolism was measured in hippocampal slices from young and old rats. Slices were prelabeled with H-3-inositol for 120 min and subjected to muscarinic stimulation in the presence of lithium. Following extraction of the slices with acidified solvent mixture, the inositolphosphates present in the aqueous fraction were isolated by ion exchange chromatography. Receptor-stimulated release of inositolphosphates (IPs) was found to be increased in the hippocampus of older animals. This age-related enhancement of IP release was in contrast to the decrease in choline acetyltransferase (CHAT) activity in the hippocampus. We postulate that alterations in the G-protein coupling with the muscarinic receptor leads to an increase in the phosphoinositide turnover in part as a compensatory mechanism for neuronal cell death and reduced transmitter levels. C1 NIEHS,MOLEC & INTEGRAT NEUROSCI LAB,RES TRIANGLE PK,NC 27709. NATL CTR TOXICOL RES,DIV REPROD & DEV TOXICOL,JEFFERSON,AR 72079. NR 62 TC 35 Z9 35 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0091-3057 J9 PHARMACOL BIOCHEM BE JI Pharmacol. Biochem. Behav. PD APR PY 1991 VL 38 IS 4 BP 861 EP 867 DI 10.1016/0091-3057(91)90254-Y PG 7 WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy GA FJ069 UT WOS:A1991FJ06900026 PM 1651520 ER PT J AU GEORGE, FR ELMER, GI MEISCH, RA GOLDBERG, SR AF GEORGE, FR ELMER, GI MEISCH, RA GOLDBERG, SR TI ORALLY DELIVERED COCAINE FUNCTIONS AS A POSITIVE REINFORCER IN C57BL/6J MICE SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR LA English DT Article DE COCAINE; SELF-ADMINISTRATION; C57BL/6J MICE; FIXED RATIO ID RHESUS-MONKEYS; DEPRESSED-PATIENTS; FOOD PRESENTATION; SQUIRREL-MONKEY; D-AMPHETAMINE; ETHANOL; BEHAVIOR; RATS; SCHEDULE; ESTABLISHMENT AB Cocaine serves as a reinforcer across several routes of administration and species. However, whether orally delivered cocaine serves as a positive reinforcer has not been systematically established. We determined the extent to which contingent access to orally delivered cocaine would maintain lever pressing behavior in C57BL/6J mice who had a prior history of operant ethanol-reinforced behavior. The findings presented in this report demonstrate that orally delivered cocaine can serve as a reinforcer of operant behavior. A drug substitution procedure where cocaine was substituted for gradually decreasing ethanol concentrations was successful in inducing pharmacologically significant intakes of cocaine under a fixed ratio (FR) schedule of drug access. When ethanol was removed, responding for cocaine continued. As FR size was increased, proportionate increases in responding occurred except at the highest FR value. Responding maintained by cocaine significantly exceeded responding maintained by vehicle, with the mice typically consuming 6-10 mg/kg cocaine per 30-min session. The utilization of inbred strains and the procedures followed in the present studies should prove useful in determining the extent of both genetic and environmental influences on various behavioral effects of cocaine and their mechanisms of action. C1 NIDA,ADDICT RES CTR,PRECLIN PHARMACOL BRANCH,BALTIMORE,MD 21224. UNIV TEXAS,HLTH SCI CTR,DEPT PSYCHIAT & BEHAV SCI,HOUSTON,TX 77030. RP GEORGE, FR (reprint author), UNIV MARYLAND,SCH PHARM,DEPT PHARMACOL & TOXICOL,20 N PINE ST,BALTIMORE,MD 21201, USA. FU NIAAA NIH HHS [AA-07754, AA-06104/06924]; NIDA NIH HHS [DA-00944] NR 55 TC 40 Z9 40 U1 3 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0091-3057 J9 PHARMACOL BIOCHEM BE JI Pharmacol. Biochem. Behav. PD APR PY 1991 VL 38 IS 4 BP 897 EP 903 DI 10.1016/0091-3057(91)90260-9 PG 7 WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy GA FJ069 UT WOS:A1991FJ06900032 PM 1871203 ER PT J AU RAUSCHECKER, JP AF RAUSCHECKER, JP TI MECHANISMS OF VISUAL PLASTICITY - HEBB SYNAPSES, NMDA RECEPTORS, AND BEYOND SO PHYSIOLOGICAL REVIEWS LA English DT Review ID LONG-TERM POTENTIATION; MONOCULARLY DEPRIVED KITTENS; OCULAR DOMINANCE PLASTICITY; LATERAL GENICULATE-NUCLEUS; EXCITATORY AMINO-ACIDS; PROTEIN-KINASE-C; DARK-REARED CATS; CORTICAL ORIENTATION SELECTIVITY; MOVEMENT DETECTION TASK; RETINAL GANGLION-CELLS C1 MAX PLANCK INST BIOL CYBERNET,TUBINGEN,GERMANY. RP RAUSCHECKER, JP (reprint author), NIMH,CTR ANIM,POOLESVILLE,MD 20837, USA. RI Rauschecker, Josef/A-4120-2013 NR 435 TC 190 Z9 192 U1 6 U2 10 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0031-9333 J9 PHYSIOL REV JI Physiol. Rev. PD APR PY 1991 VL 71 IS 2 BP 587 EP 615 PG 29 WC Physiology SC Physiology GA FE049 UT WOS:A1991FE04900008 PM 1826058 ER PT J AU KIM, YA BARBEAU, WE AF KIM, YA BARBEAU, WE TI CHANGES IN THE NUTRITIVE-VALUE OF SOY PROTEIN-CONCENTRATE DURING AUTOCLAVING SO PLANT FOODS FOR HUMAN NUTRITION LA English DT Article DE SOY PROTEIN; THERMAL PROCESSING; PROTEIN QUALITY AB Soy protein concentrate (Promosoy R Plus) was mixed with water to form a thick paste and autoclaved at 121-degrees-C for 10 min, 30 min, 2 h, or 4 h. Unautoclaved SPC served as a control. Nitrogen solubility measurements and SDS-PAGE analysis indicated that autoclaving resulted in the formation of soy protein aggregates, with a MW of approximately 1 million daltons, held together by non-covalent and disulfide bonds. The 10 min, 30 min, 2 h, and 4 h SPC samples contained 6, 20, 27 and 39% less cysteine, respectively, than the SPC control. No significant differences were found in the PERs, 2.6-2-7, of a casein control, unautoclaved SPC control and 10 min and 30 min autoclaved samples. PERs of the 2 h and 4 h autoclaved samples, 2.0 and 1.9 respectively, were significantly lower than the other four diets. No significant differences were found in the apparent digestibility of the 10 min, 30 min, and 2 h autoclaved samples; the 4 h autoclaved sample however was significantly less digestible. Decreased PERs of autoclaved SPC samples were likely due to (1) cysteine destruction, (2) decreased protein digestibility, and (3) decreased food intake. C1 NIAAA,ROCKVILLE,MD 20852. NR 0 TC 5 Z9 5 U1 2 U2 2 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0921-9668 J9 PLANT FOOD HUM NUTR JI Plant Food Hum. Nutr. PD APR PY 1991 VL 41 IS 2 BP 179 EP 192 DI 10.1007/BF02194086 PG 14 WC Plant Sciences; Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics SC Plant Sciences; Chemistry; Food Science & Technology; Nutrition & Dietetics GA FJ798 UT WOS:A1991FJ79800008 PM 1852729 ER PT J AU BROWN, PS PARENTEAU, GL DIRBAS, FM GARSIA, RJ GOLDMAN, CK BUKOWSKI, MA JUNGHANS, RP QUEEN, C HAKIMI, J BENJAMIN, WR CLARK, RE WALDMANN, TA AF BROWN, PS PARENTEAU, GL DIRBAS, FM GARSIA, RJ GOLDMAN, CK BUKOWSKI, MA JUNGHANS, RP QUEEN, C HAKIMI, J BENJAMIN, WR CLARK, RE WALDMANN, TA TI ANTI-TAC-H, A HUMANIZED ANTIBODY TO THE INTERLEUKIN-2 RECEPTOR, PROLONGS PRIMATE CARDIAC ALLOGRAFT SURVIVAL SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article ID MONOCLONAL-ANTIBODY; BINDS; CELLS AB High-affinity interleukin 2 receptors (IL-2Rs) are expressed by T cells activated in response to foreign histocompatibility antigens but not by normal resting T cells. To exploit this difference in IL-2R expression, anti-Tac-M, a murine monoclonal antibody specific for the IL-2R-alpha chain, was used to inhibit organ allograft rejection. However, the use of murine anti-Tac as an immunosuppressive agent was limited by neutralization by human anti-murine antibodies and by weak recruitment of effector functions. To circumvent these difficulties, a humanized antibody to the IL-2R, anti-Tac-H, was prepared. This molecule is human with the exception of the hypervariable segments, which are retained from the mouse. In vivo survival of anti-Tac-H is 2.5-fold longer than simultaneously administered anti-Tac-M (terminal t1/2, 103 hr vs. 38 hr). In addition, anti-Tac-H is less immunogenic than anti-Tac-M when administered to cynomolgus monkeys undergoing heterotopic cardiac allografting. Specifically, all monkeys treated with anti-Tac-M developed measurable anti-anti-Tac-M levels by day 15 (mean onset, 11 days). In contrast, none of the animals receiving anti-Tac-H produced measurable antibodies to this monoclonal antibody before day 33. Finally, there was a prolongation of graft survival in the cynomolgus heterotopic cardiac allograft model in animals receiving anti-Tac. In animals that received anti-Tac-M, the allograft survival was prolonged compared to that of the control group (mean survival, 14 +/- 1.98 days compared to 9.2 +/- 0.48 days; P < 0.025). Graft survival was further prolonged by anti-Tac-H with a mean survival of 20.0 +/- 0.55 days (compared to controls, P < 0.001; compared to anti-Tac-M, P < 0.02). There was no toxicity attributable to the administration of either form of anti-Tac. Thus, anti-Tac-H significantly prolonged allograft survival in primates, without toxic side effects, and may be of value as an adjunct to standard immunosuppressive therapy in humans. C1 NCI,METAB BRANCH,BLDG 10,ROOM 4N115,BETHESDA,MD 20892. NHLBI,SURG BRANCH,BETHESDA,MD 20892. PROT DESIGN LABS INC,MT VIEW,CA 94043. HOFFMANN LA ROCHE INC,NUTLEY,NJ 07110. NR 25 TC 108 Z9 112 U1 1 U2 3 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR PY 1991 VL 88 IS 7 BP 2663 EP 2667 DI 10.1073/pnas.88.7.2663 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FE864 UT WOS:A1991FE86400011 PM 2011577 ER PT J AU CUTTING, GR LU, L OHARA, BF KASCH, LM MONTROSERAFIZADEH, C DONOVAN, DM SHIMADA, S ANTONARAKIS, SE GUGGINO, WB UHL, GR KAZAZIAN, HH AF CUTTING, GR LU, L OHARA, BF KASCH, LM MONTROSERAFIZADEH, C DONOVAN, DM SHIMADA, S ANTONARAKIS, SE GUGGINO, WB UHL, GR KAZAZIAN, HH TI CLONING OF THE GAMMA-AMINOBUTYRIC-ACID (GABA) RHO-1 CDNA - A GABA RECEPTOR SUBUNIT HIGHLY EXPRESSED IN THE RETINA SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE LIGAND-GATED ION-CHANNEL RECEPTORS; POLYMERASE CHAIN REACTION; CHLORIDE CHANNELS; GENE FAMILY; OOCYTE EXPRESSION ID ALPHA-SUBUNIT; FUNCTIONAL EXPRESSION; CHLORIDE CHANNELS; SEQUENCE; PROTEIN; FAMILY; SHOWS; AMPLIFICATION; SPECIFICITY; SITES AB Type A gamma-aminobutyric acid (GABA(A)) receptors are a family of ligand-gated chloride channels that are the major inhibitory neurotransmitter receptors in the nervous system. Molecular cloning has revealed diversity in the subunits that compose this heterooligomeric receptor, but each previously elucidated subunit displays amino acid similarity in conserved structural elements. We have used these highly conserved regions to identify additional members of this family by using the polymerase chain reaction (PCR). One PCR product was used to isolate a full-length cDNA from a human retina cDNA library. The mature protein predicted from this cDNA sequence is 458 amino acids long and displays between 30 and 38% amino acid similarity to the previously identified GABA(A) subunits. This gene is expressed primarily in the retina but transcripts are also detected in the brain, lung, and thymus. Injection of Xenopus oocytes with RNA transcribed in vitro produces a GABA-responsive chloride conductance and expression of the cDNA in COS cells yields GABA-displaceable muscimol binding. These features are consistent with our identification of a GABA subunit, GABA rho-1, with prominent retinal expression that increases the diversity and tissue specificity of this ligand-gated ion-channel receptor family. C1 JOHNS HOPKINS UNIV,SCH MED,DEPT PEDIAT,BALTIMORE,MD 21205. JOHNS HOPKINS UNIV,SCH MED,DEPT PHYSIOL,BALTIMORE,MD 21205. JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL,BALTIMORE,MD 21205. JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21205. JOHNS HOPKINS UNIV,SCH MED,CTR MED GENET,BALTIMORE,MD 21205. NIDA,ADDICT RES CTR,MOLEC NEUROBIOL LAB,BALTIMORE,MD 21224. NR 45 TC 444 Z9 448 U1 0 U2 4 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR PY 1991 VL 88 IS 7 BP 2673 EP 2677 DI 10.1073/pnas.88.7.2673 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FE864 UT WOS:A1991FE86400013 PM 1849271 ER PT J AU CARTER, RH PARK, DJ RHEE, SG FEARON, DT AF CARTER, RH PARK, DJ RHEE, SG FEARON, DT TI TYROSINE PHOSPHORYLATION OF PHOSPHOLIPASE-C INDUCED BY MEMBRANE IMMUNOGLOBULIN IN LYMPHOCYTES-B SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE CALCIUM; INOSITOL PHOSPHATE; TYROSINE KINASE; PHOSPHOLIPASE C-GAMMA-1 ID PROTEIN KINASE-C; GROWTH-FACTOR; SIGNAL TRANSDUCTION; HEMATOPOIETIC-CELLS; ANTIGEN RECEPTOR; GENE HCK; ACTIVATION; HYDROLYSIS; IGM; PHOSPHATIDYLINOSITOL AB Ligation of membrane IgM on B lymphocytes causes activation of a protein-tyrosine kinase(s) (PTK) and of phospholipase C (PLC). To determine whether these are elements of a common signal-transduction pathway, the effect of three PTK inhibitors on the rise in intracellular free Ca2+ concentration ([Ca2+]i) in human B-lymphoblastoid cell lines was assessed. Tyrphostin completely suppressed the increase in [Ca2+]i and the generation of inositol phosphates induced by ligation of membrane immunoglobulin (mIg) M. Herbimycin and genistein reduced by 30% and 50%, respectively, the rise in [Ca2+]i caused by optimal ligation of mIgM, and they abolished it in cells activated by suboptimal ligation of mIgM. Tyrphostin had no effect on the capacity of aluminum fluoride to increase [Ca2+]i. To determine whether a function of PTK is the phosphorylation of PLC, immunoprecipitates obtained with anti-phosphotyrosine from detergent lysates of B-lymphoblastoid cells were assayed for PLC activity. Ligation of mIgM increased immunoprecipitable PLC activity 2-fold by 90 sec and 4-fold by 30 min. Specific immunoprecipitation and Western blot analysis identified tyrosine phosphorylation of the gamma-1 isoform of PLC after 60 sec of stimulation. Activation of PLC in B cells by mIgM requires PTK function and is associated with tyrosine phosphorylation of PLC-gamma-1, suggesting a mechanism of PLC activation similar to that described for certain receptor PTKs. C1 NHLBI,BIOCHEM LAB,BETHESDA,MD 20892. JOHNS HOPKINS UNIV,SCH MED,GRAD PROGRAM IMMUNOL,BALTIMORE,MD 21205. RP CARTER, RH (reprint author), JOHNS HOPKINS UNIV,SCH MED,DEPT MED,BALTIMORE,MD 21205, USA. RI Park, Do-Joon/J-2736-2012 FU NIAID NIH HHS [AI28191, AI22833] NR 37 TC 251 Z9 252 U1 0 U2 0 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR PY 1991 VL 88 IS 7 BP 2745 EP 2749 DI 10.1073/pnas.88.7.2745 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FE864 UT WOS:A1991FE86400028 PM 2011584 ER PT J AU NEVE, KA NEVE, RL FIDEL, S JANOWSKY, A HIGGINS, GA AF NEVE, KA NEVE, RL FIDEL, S JANOWSKY, A HIGGINS, GA TI INCREASED ABUNDANCE OF ALTERNATIVELY SPLICED FORMS OF D2 DOPAMINE RECEPTOR MESSENGER-RNA AFTER DENERVATION SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article ID PARKINSONS-DISEASE; AUTORADIOGRAPHIC LOCALIZATION; GBR-12935 BINDING; D-2 RECEPTORS; RAT-BRAIN; EXPRESSION; D2-RECEPTOR; FOREBRAIN; CDNA AB The existence of two molecular forms of D2 dopamine receptors suggests that differences in the distribution or regulation of the two forms could be exploited for the pharmacological treatment of disease. Using probes selective for each alternatively spliced variant of D2 receptor mRNA, we determined that both variants were widely distributed in rat brain and pituitary but that the ratio of the forms varied among regions. mRNA for the 444-amino acid-long variant, D2(444), was the most abundant form in pituitary and neostriatum. Intermediate levels of both D2(444) mRNA and the short form, D2(415), were detected in midbrain, and low levels of D2(444) and D2(415) mRNAs were detected in all other regions examined, including hippocampus, cerebellum, and cortex. The D2(444)/D2(415) ratio was generally lower in the regions of low expression than in pituitary and neostriatum. Dopamine-depleting lesions increased the density of D2 receptors in the denervated neostriatum by 29% without altering the affinity of the receptors for [H-3]spiperone. The proliferation of receptors appeared to be due to a lesion-induced increase of up to 120% in the abundance of both variants of mRNA in the neostriatum. C1 OREGON HLTH SCI UNIV,DEPT PSYCHIAT,PORTLAND,OR 97201. OREGON HLTH SCI UNIV,DEPT PHARMACOL,PORTLAND,OR 97201. NIA,GERONTOL RES CTR,BALTIMORE,MD 21224. UNIV CALIF IRVINE,DEPT PSYCHOBIOL,IRVINE,CA 92717. RP NEVE, KA (reprint author), VET AFFAIRS MED CTR,PORTLAND,OR 97201, USA. FU NICHD NIH HHS [HD18658]; NIMH NIH HHS [MH45372, MH42894] NR 36 TC 100 Z9 100 U1 1 U2 1 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR PY 1991 VL 88 IS 7 BP 2802 EP 2806 DI 10.1073/pnas.88.7.2802 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FE864 UT WOS:A1991FE86400040 PM 1826366 ER PT J AU HUBER, M CABIB, E MILLER, LH AF HUBER, M CABIB, E MILLER, LH TI MALARIA PARASITE CHITINASE AND PENETRATION OF THE MOSQUITO PERITROPHIC MEMBRANE SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE PLASMODIUM-GALLINACEUM; AEDES-AEGYPTI; VECTOR COMPETENCE ID AEDES-AEGYPTI; PURIFICATION; PLASMODIUM; DIPTERA; MIDGUT AB Malaria parasites (ookinetes) appear to digest the peritrophic membrane in the mosquito midgut during penetration. Previous studies demonstrated that lectins specific for N-acetylglucosamine bind to the peritrophic membrane and proposed that the membrane contains chitin [Rudin, W. & Hecker, H. (1989) Parasitol. Res. 75, 268-279]. In the present study, we show that the peritrophic membrane is digested by Serratia marcescens chitinase (EC 3.2.1.14), leading to the release of N-acetylglucosamine and fragmentation of the membrane. We also report the presence of a malaria parasite chitinase that digests 4-methylumbelliferyl chitotriose. The enzyme is not detectable until 15 hr after zygote formation, the time required for maturation of the parasite from a zygote to an ookinete, the invasive form of the parasite. At 20 hr, the enzyme begins to appear in the culture supernatant. The chitinase extracted from the parasite and found in the culture supernatant consists of a major band and two minor bands of activity on native polyacrylamide gel electrophoresis. The presence of chitin in the peritrophic membrane, the disruption of the peritrophic membrane during invasion, and the presence of chitinase in ookinetes suggest that the chitinase in ookinetes is used in the penetration of the peritrophic membrane. C1 NIAID,PARASIT DIS LAB,BLDG 4,ROOM 126,BETHESDA,MD 20892. NIDDKD,BIOCHEM & METAB LAB,BETHESDA,MD 20892. NR 18 TC 158 Z9 164 U1 1 U2 10 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR PY 1991 VL 88 IS 7 BP 2807 EP 2810 DI 10.1073/pnas.88.7.2807 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FE864 UT WOS:A1991FE86400041 PM 2011589 ER PT J AU WOLFF, J KNIPLING, L CAHNMANN, HJ PALUMBO, G AF WOLFF, J KNIPLING, L CAHNMANN, HJ PALUMBO, G TI DIRECT PHOTOAFFINITY-LABELING OF TUBULIN WITH COLCHICINE SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article ID MICROTUBULE-ASSOCIATED PROTEINS; BINDING-SITE; BETA-TUBULIN; DISSOCIATION; IDENTIFICATION; MUTANTS; DIMER AB Ultraviolet irradiation of the [H-3]colchicine-tubulin complex leads to direct photolabeling of tubulin with low but practicable efficiency. The bulk (70% to > 90%) of the labeling occurs on beta-tubulin and appears early after irradiation, whereas alpha-tubulin is labeled later. The labeling ratio of beta-tubulin to alpha-tubulin (beta/alpha-ratio) is reduced by prolonged incubation, prolonged irradiation, urea, high ionic strength, the use of aged tubulin, dilution of tubulin, or large concentrations of colchicine or podophyllotoxin. Glycerol increases the beta/alpha-ratio. Limited data with [H-3]podophyllotoxin show that it covalently bound with a similar beta/alpha distribution. Vinblastine, on the other hand, exhibits preferential attachment to alpha-tubulin. The possibilities that colchicine binds at the interface between alpha-tubulin and beta-tubulin, that the drug spans this interface, and that both subunits may contribute to the binding site are suggested. RP WOLFF, J (reprint author), NIH,BLDG 10,ROOM 8N312,BETHESDA,MD 20892, USA. OI Palumbo, Giuseppe/0000-0001-9380-8436 NR 30 TC 60 Z9 61 U1 0 U2 1 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR PY 1991 VL 88 IS 7 BP 2820 EP 2824 DI 10.1073/pnas.88.7.2820 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FE864 UT WOS:A1991FE86400044 PM 2011590 ER PT J AU SEDER, RA PAUL, WE DVORAK, AM SHARKIS, SJ KAGEYSOBOTKA, A NIV, Y FINKELMAN, FD BARBIERI, SA GALLI, SJ PLAUT, M AF SEDER, RA PAUL, WE DVORAK, AM SHARKIS, SJ KAGEYSOBOTKA, A NIV, Y FINKELMAN, FD BARBIERI, SA GALLI, SJ PLAUT, M TI MOUSE SPLENIC AND BONE-MARROW CELL-POPULATIONS THAT EXPRESS HIGH-AFFINITY FC-EPSILON RECEPTORS AND PRODUCE INTERLEUKIN-4 ARE HIGHLY ENRICHED IN BASOPHILS SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE MAST CELL; HISTAMINE; IMMUNOGLOBULIN-E ID MAST-CELLS; DE-GRANULATION; P-CELL; HISTAMINE; LEUKOCYTES; MICE; IGE; DIFFERENTIATION; ACTIVATION; INVITRO AB Splenic and bone marrow cells from normal mice, and from mice that have been polyclonally activated by injection of anti-IgD antibody, contain cells that produce interleukin 4 (IL-4) in response to crosslinkage of Fc-epsilon-receptors (Fc-epsilon-R) or Fc-gamma-R or to ionomycin. Isolated Fc-epsilon-R+ cells have recently been shown to contain all of the IL-4-producing capacity of the nonlymphoid compartment of spleen and bone marrow. Here, purified Fc-epsilon-R+ cells are shown to be enriched in cells that contain histamine and express alcian blue-positive cytoplasmic granules. By electron microscopy, the vast majority of cytoplasmic granule-containing cells are basophils; they constitute almost-equal-to 25% and almost-equal-to 50%, respectively, of Fc-epsilon-R+ spleen and bone marrow cells from anti-IgD-injected mice. The Fc-epsilon-R- populations contain cells that form colonies typical of mast cells. The Fc-epsilon-R+ populations also contain cells that, upon culture with IL-3, form colonies of alcian blue-positive cells, but (in contrast to colonies derived from Fc-epsilon-R- populations) the colonies are small, and all the cells die within 2-3 weeks. The Fc-epsilon-R+ cells synthesize histamine during a 60-hr culture with IL-3, while the Fc-epsilon-R- cells do not. These results indicate that IL-4-producing Fc-epsilon-R+ cells are highly enriched in basophils. C1 JOHNS HOPKINS UNIV,JOHNS HOPKINS ASTHMA & ALLERGY CTR,DEPT MED,DIV CLIN IMMUNOL,BALTIMORE,MD 21218. NIAID,BIOL RESOURCES BRANCH,BETHESDA,MD 20892. NIAID,DEPT IMMUNOL,BETHESDA,MD 20892. BETH ISRAEL HOSP,DEPT PATHOL,BOSTON,MA 02215. JOHNS HOPKINS UNIV HOSP,CTR ONCOL,BALTIMORE,MD 21205. BETH ISRAEL HOSP,CHARLES A DANA RES INST,BOSTON,MA 02215. JOHNS HOPKINS MED INST,BALTIMORE,MD 21205. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. HARVARD UNIV,SCH MED,BOSTON,MA 02115. FU NCI NIH HHS [CA28834, CA48647]; NIAID NIH HHS [AI27906] NR 42 TC 215 Z9 216 U1 0 U2 0 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR PY 1991 VL 88 IS 7 BP 2835 EP 2839 DI 10.1073/pnas.88.7.2835 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FE864 UT WOS:A1991FE86400047 PM 1826367 ER PT J AU KIM, SJ LEE, HD ROBBINS, PD BUSAM, K SPORN, MB AF KIM, SJ LEE, HD ROBBINS, PD BUSAM, K SPORN, MB TI REGULATION OF TRANSFORMING GROWTH FACTOR-BETA-1 GENE-EXPRESSION BY THE PRODUCT OF THE RETINOBLASTOMA-SUSCEPTIBILITY GENE SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE PROMOTER; RETINOBLASTOMA RESPONSE ELEMENT; TUMOR SUPPRESSOR; GROWTH FACTOR ID FACTOR-BETA; CELLS; ONCOGENE; DIFFERENTIATION; INHIBITOR; JUN; DNA AB Transforming growth factor-beta (TGF-beta) isoforms inhibit the growth of many cell types and block progression of the cell cycle by inhibiting events in late G1 phase. The retinoblastoma gene product, RB, also has properties of a cell-cycle regulatory factor. It remains underphosphorylated in the presence of TGF-beta and has been shown to repress the activity of the c-fos promoter, resulting in inhibition of transit through the cell cycle. These observations led us to examine effects of human RB on the expression of the human TGF-beta-1 gene. Using chimeric TGF-beta-1 promoter-chloramphenicol acetyltransferase gene constructs, we show that RB induces TGF-beta-1 gene expression in CCL-64 mink lung epithelial cells and A-549 human lung adenocarcinoma cells but represses its expression in NIH 3T3 and AKR-2B mouse cells. Several sequences homologous to the c-fos RB control element were identified in the TGF-beta-1 promoter. These results demonstrate that human RB can regulate TGF-beta-1 gene expression negatively or positively depending on the cell type. C1 UNIV PITTSBURGH,SCH MED,DEPT MOLEC GENET & BIOCHEM,PITTSBURGH,PA 15261. RP KIM, SJ (reprint author), NCI,CHEMOPREVENT LAB,BLDG 41,ROOM B1106,BETHESDA,MD 20892, USA. NR 32 TC 175 Z9 175 U1 0 U2 0 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR PY 1991 VL 88 IS 8 BP 3052 EP 3056 DI 10.1073/pnas.88.8.3052 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FG913 UT WOS:A1991FG91300018 PM 1901652 ER PT J AU TAMKUN, JW KAHN, RA KISSINGER, M BRIZUELA, BJ RULKA, C SCOTT, MP KENNISON, JA AF TAMKUN, JW KAHN, RA KISSINGER, M BRIZUELA, BJ RULKA, C SCOTT, MP KENNISON, JA TI THE ARFLIKE GENE ENCODES AN ESSENTIAL GTP-BINDING PROTEIN IN DROSOPHILA SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article ID ADP-RIBOSYLATION FACTOR; GUANINE-NUCLEOTIDE-BINDING; ADENYLATE-CYCLASE; RNA-POLYMERASE; CHOLERA-TOXIN; EXPRESSION; COFACTOR; SEQUENCE; DNA; PURIFICATION AB We have identified a Drosophila gene (arflike, arl) encoding a protein that is structurally related (almost-equal-to 55% identity) to the ADP-ribosylation factors (ARFs) of yeast and mammals. Biochemical analyses of purified recombinant arl-encoded protein revealed properties similar to the ARF proteins, including the ability to bind and hydrolyze GTP. Clear functional differences between arl and ARF proteins, including a complete lack of ARF activity, suggest that arl is not a functional homolog of ARF. A recessive lethal arl mutation was recovered, demonstrating that the arl locus is an essential gene. We conclude that the arl locus encodes an essential member of the ARF subfamily of small GTP-binding proteins in Drosophila. C1 UNIV COLORADO,DEPT MOLEC CELLULAR & DEV BIOL,BOULDER,CO 80309. NCI,DIV CANC TREATMENT,BIOL CHEM LAB,BETHESDA,MD 20892. NICHHD,MOLEC GENET LAB,BETHESDA,MD 20892. RP TAMKUN, JW (reprint author), UNIV CALIF SANTA CRUZ,DEPT BIOL,SINSHEIMER LABS 323,SANTA CRUZ,CA 95064, USA. NR 40 TC 123 Z9 128 U1 0 U2 1 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR PY 1991 VL 88 IS 8 BP 3120 EP 3124 DI 10.1073/pnas.88.8.3120 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FG913 UT WOS:A1991FG91300033 PM 1901655 ER PT J AU STEINFELDER, HJ HAUSER, P NAKAYAMA, Y RADOVICK, S MCCLASKEY, JH TAYLOR, T WEINTRAUB, BD WONDISFORD, FE AF STEINFELDER, HJ HAUSER, P NAKAYAMA, Y RADOVICK, S MCCLASKEY, JH TAYLOR, T WEINTRAUB, BD WONDISFORD, FE TI THYROTROPIN-RELEASING-HORMONE REGULATION OF HUMAN TSHB EXPRESSION - ROLE OF A PITUITARY-SPECIFIC TRANSCRIPTION FACTOR (PIT-1/GHF-1) AND POTENTIAL INTERACTION WITH A THYROID HORMONE-INHIBITORY ELEMENT SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE CIS-ACTING ELEMENT; THYROTROPH; DNA-BINDING ASSAY; TRANS-ACTING FACTOR ID BETA-SUBUNIT GENE; CELL-SPECIFIC EXPRESSION; PROMOTER ACTIVITY; PROLACTIN GENE; GROWTH-HORMONE; RECEPTORS; CULTURE AB Regulation of human thyrotropin beta-subunit gene (TSHB) expression by thyrotropin-releasing hormone (TRH) was examined in a clonal rat pituitary-cell line (GH3). Transient expression studies were done with various 5'-flanking DNA sequences of TSHB coupled to reporter gene chloramphenicol acetyltransferase. Deletion analysis defined two discrete regions (-128 to -92 base pairs and -28 to +8 base pairs) that each mediated an almost-equal-to 2-fold TRH induction. The upstream site contains a DNA sequence with close homology to the DNA-binding site for a pituitary-specific transcriptional factor Pit-1/GHF-1. DNase I footprinting analysis of mouse thyrotropic tumor extract as well as DNA-transfection studies using an expression vector containing an N-terminal deletion of Pit-1/GHF-1 cDNA suggest that Pit-1/GHF-1 or a closely related protein in the thyrotroph mediates TRH responsiveness of this gene. In addition, the downstream site overlaps with the recently characterized thyroid hormone-inhibitory element of TSHB. In fact, deletion of DNA sequences important in thyroid hormone-receptor binding (c-erbAB/c-ERBA2) from +3 to +8 base pairs, significantly reduced (30%) TRH responsiveness. The location of a TRH-stimulatory element near a thyroid hormone-inhibitory element may allow for fine control of TSHB expression in vivo. C1 NIDDKD,MOLEC CELLULAR & NUTR ENDOCRINOL BRANCH,BETHESDA,MD 20892. GEORGETOWN UNIV HOSP,WASHINGTON,DC 20007. NR 28 TC 115 Z9 118 U1 0 U2 2 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR PY 1991 VL 88 IS 8 BP 3130 EP 3134 DI 10.1073/pnas.88.8.3130 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FG913 UT WOS:A1991FG91300035 PM 1901656 ER PT J AU WATERS, AP HIGGINS, DG MCCUTCHAN, TF AF WATERS, AP HIGGINS, DG MCCUTCHAN, TF TI PLASMODIUM-FALCIPARUM APPEARS TO HAVE ARISEN AS A RESULT OF LATERAL TRANSFER BETWEEN AVIAN AND HUMAN HOSTS SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE MALARIA; PHYLOGENY; SMALL-SUBUNIT RIBOSOMAL RNA; FARENHOLZ RULE ID RIBOSOMAL-RNA GENE; SEQUENCE; MICROCOMPUTER; PHYLOGENIES; DNA AB It has been proposed that the acquisition of Plasmodium falciparum by man is a relatively recent event and that the sustained presence of this disease in man is unlikely to have been possible prior to the establishment of agriculture. To establish phylogenetic relationships among the Plasmodium species and to unravel the mystery of the origin of P. falciparum, we have analyzed and compared phylogenetically the small-subunit ribosomal RNA gene sequences of the species of malaria that infect humans as well as a number of those sequences from species that infect animals. Although this comparison confirmed the three established major subgroups, broadly classed as avian, simian, and rodent, we find that the human pathogen P. falciparum is monophyletic with the avian subgroup, indicating that P. falciparum and avian parasites share a relatively recent avian progenitor. The other important human pathogen, P. vivax, is very similar to a representative of the simian group of Plasmodium. The relationship between P. falciparum and the avian parasites, and the overall phylogeny of the genus, provides evidence of an exception to Farenholz's rule, which propounds synchronous speciation between host and parasite. C1 NIAID,PARASIT DIS LAB,MALARIA SECT,BLDG 4,BETHESDA,MD 20892. EUROPEAN MOLEC BIOL ORG DATA LIB,W-6900 HEIDELBERG,GERMANY. RI Waters, Andy/C-9377-2009; Higgins, des/J-6314-2012 OI Waters, Andy/0000-0001-8900-2982; NR 26 TC 183 Z9 184 U1 0 U2 12 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR PY 1991 VL 88 IS 8 BP 3140 EP 3144 DI 10.1073/pnas.88.8.3140 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FG913 UT WOS:A1991FG91300037 PM 2014232 ER PT J AU FLANAGAN, JR MURATA, M BURKE, PA SHIRAYOSHI, Y APPELLA, E SHARP, PA OZATO, K AF FLANAGAN, JR MURATA, M BURKE, PA SHIRAYOSHI, Y APPELLA, E SHARP, PA OZATO, K TI NEGATIVE REGULATION OF THE MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I PROMOTER IN EMBRYONAL CARCINOMA-CELLS SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE DNA-BINDING PROTEIN ID POLYOMA-VIRUS ENHANCER; LONG TERMINAL REPEAT; GENE-EXPRESSION; LEUKEMIA-VIRUS; TERATOCARCINOMA CELLS; NUCLEAR FACTORS; STEM-CELLS; SEQUENCE; INTERFERON; BINDING AB Transcription of major histocompatibility complex (MHC) class I genes is negatively regulated in undifferentiated F9 mouse embryonal carcinoma cells via the conserved upstream regulatory region. This region contains constitutive enhancers and an inducible enhancer, the interferon consensus sequence (ICS), that is responsible for interferon-induced transcription. A series of mutations in the ICS, but not in the enhancer elements, resulted in an increase in expression of the MHC class I promoter in F9 cells. However, these ICS mutants did not increase promoter activity in F9 cells differentiated after retinoic acid treatment. Results of mobility-shift DNA-binding assays and methylation interference experiments showed that undifferentiated F9 cells contained a factor(s) that bound to a sequence within the 5' and central part of the ICS. This binding site, termed the MHC negative regulatory element (NRE), coincided with the site of mutations that increased promoter activity in F9 cells and was distinct from the element to which interferon-response factors bind. The factor(s) that binds to the MHC NRE was not detected in differentiated F9 cells treated with retinoic acid or in other cells expressing MHC class I genes. Finally, introduction of concatenated, double-stranded NRE oligomers, but not oligomers of unrelated sequences, into F9 cells abolished negative regulation of the MHC class I promoter activity, providing evidence that the NRE binding factor is responsible for repression of the MHC class I genes in F9 cells. C1 NICHHD,DEV & MOLEC IMMUN LAB,BLDG 6,ROOM 2A01,BETHESDA,MD 20892. MIT,CTR CANC RES,CAMBRIDGE,MA 02139. MIT,DEPT BIOL,CAMBRIDGE,MA 02139. NCI,CELL BIOL LAB,BETHESDA,MD 20892. FU NCI NIH HHS [P01-CA42063, P30-CA14051] NR 39 TC 55 Z9 55 U1 1 U2 4 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR PY 1991 VL 88 IS 8 BP 3145 EP 3149 DI 10.1073/pnas.88.8.3145 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FG913 UT WOS:A1991FG91300038 PM 2014233 ER PT J AU CULVER, K CORNETTA, K MORGAN, R MORECKI, S AEBERSOLD, P KASID, A LOTZE, M ROSENBERG, SA ANDERSON, WF BLAESE, RM AF CULVER, K CORNETTA, K MORGAN, R MORECKI, S AEBERSOLD, P KASID, A LOTZE, M ROSENBERG, SA ANDERSON, WF BLAESE, RM TI LYMPHOCYTES AS CELLULAR VEHICLES FOR GENE-THERAPY IN MOUSE AND MAN SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE RETROVIRAL VECTOR; TUMOR-INFILTRATING LYMPHOCYTE; INTERLEUKIN-2; NEOMYCIN RESISTANCE; ADENOSINE DEAMINASE ID HUMAN ADENOSINE-DEAMINASE; EXPRESSION; CELLS AB The application of bone marrow gene therapy has been stalled by the inability to achieve stable high-level gene transfer and expression in the totipotent stem cells. We show that retroviral vectors can stably introduce genes into antigen-specific murine and human T lymphocytes in culture. Murine helper T cells were transduced with the retroviral vector SAX to express both neomycin-resistance and human adenosine deaminase genes. These cells were expanded in culture and selected for expression of neomycin resistance with G418. The gene insertion, selection, and culture expansion did not alter antigen specificity or growth characteristics of the T cells in vitro. To determine if cultured T cells might be used for gene therapy, their persistence and continued expression of the introduced genes was evaluated in nude mice transplanted with the SAX-transduced T cells. G418-resistant cells could be readily recovered from the spleens of recipients of transduced T cells for several months. In addition, recovered cells continued to produce human adenosine deaminase. Based on these observations, we studied cultured human tumor-infiltrating lymphocytes as a candidate cell for a trial of gene transfer in man. Exponential cultures of interleukin-2-stimulated tumor-infiltrating lymphocytes were efficiently transduced with the neomycin-resistance gene using the retroviral vector N2. Gene insertion and subsequent G418 selection did not substantially alter the growth characteristics, interleukin 2 dependence, membrane phenotype, or cytotoxicity profile of the transduced T cells. These studies provided a portion of the experimental evidence supporting the feasibility of the presently ongoing clinical trials of lymphocyte gene therapy in cancer as well as in patients with adenosine deaminase deficiency. C1 NCI,SURG BRANCH,BETHESDA,MD 20892. NHLBI,MOLEC HEMATOL BRANCH,BETHESDA,MD 20892. RP CULVER, K (reprint author), NCI,METAB BRANCH,BETHESDA,MD 20892, USA. NR 19 TC 145 Z9 147 U1 0 U2 3 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR PY 1991 VL 88 IS 8 BP 3155 EP 3159 DI 10.1073/pnas.88.8.3155 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FG913 UT WOS:A1991FG91300040 PM 2014235 ER PT J AU VANZIJL, PCM MOONEN, CTW FAUSTINO, P PEKAR, J KAPLAN, O COHEN, JS AF VANZIJL, PCM MOONEN, CTW FAUSTINO, P PEKAR, J KAPLAN, O COHEN, JS TI COMPLETE SEPARATION OF INTRACELLULAR AND EXTRACELLULAR INFORMATION IN NMR-SPECTRA OF PERFUSED CELLS BY DIFFUSION-WEIGHTED SPECTROSCOPY SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE INTRACELLULAR METABOLISM; MEMBRANE PERMEABILITY; TRANSPORT; PROTON NMR; BREAST CANCER CELLS ID MAGNETIC-RESONANCE SPECTROSCOPY; LOCALIZED PROTON SPECTROSCOPY; BREAST CANCER-CELLS; STIMULATED ECHOES; INVIVO; PERMEABILITY; SYSTEMS; TUMORS; PLASMA AB A method is outlined that completely separates intracellular and extracellular information in NMR spectra of perfused cells. The technique uses diffusion weighting to exploit differences in motional properties between intra- and extracellular constituents. This allows monitoring of intracellular metabolism, and of transport of small drugs and nutrients through the cell membrane, under controlled physiological conditions. As a first example, proton spectra of drug-resistant MCF-7 human breast cancer cells are studied, and uptake of phenylalanine is monitored. C1 NIH,NATL CTR RES RESOURCES,INVIVO NMR RES CTR,BETHESDA,MD 20892. RP VANZIJL, PCM (reprint author), NCI,MED BRANCH,BLDG 10,ROOM B1D-125,BETHESDA,MD 20892, USA. RI van Zijl, Peter/B-8680-2008; Moonen, Chrit/K-4434-2016 OI Moonen, Chrit/0000-0001-5593-3121 NR 38 TC 157 Z9 157 U1 0 U2 8 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR PY 1991 VL 88 IS 8 BP 3228 EP 3232 DI 10.1073/pnas.88.8.3228 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FG913 UT WOS:A1991FG91300055 PM 2014244 ER PT J AU PAI, LH BATRA, JK FITZGERALD, DJ WILLINGHAM, MC PASTAN, I AF PAI, LH BATRA, JK FITZGERALD, DJ WILLINGHAM, MC PASTAN, I TI ANTITUMOR ACTIVITIES OF IMMUNOTOXINS MADE OF MONOCLONAL-ANTIBODY B3 AND VARIOUS FORMS OF PSEUDOMONAS EXOTOXIN SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE CHEMOTHERAPY; EPIDERMOID CARCINOMA; ADENOCARCINOMA ID DOMAIN; CELLS AB B3 is a monoclonal antibody that reacts with a carbohydrate epitope present on a variety of proteins located on the surface of many cancer cells and a limited number of normal tissues. We evaluated the cytotoxic activity of immunotoxins composed of monoclonal antibody B3 coupled to native Pseudomonas exotoxin (PE) or two recombinant forms of Pseudomonas exotoxin, PE(Arg57) or LysPE40, a form of PE with a deletion of the cell binding domain. All three conjugates were cytotoxic to human cell lines expressing the B3 antigen on their surface. The survival of each of the three immunotoxins in the circulation of mice was determined after administering the immunotoxin i.v. The half-life in blood of B3-PE and B3-PE(Arg57) was 20 hr, whereas the half-life of B3-LysPE40 was 4 hr. The short half-life of B3-LysPE40 may be due to the absence of domain I of PE. To determine the therapeutic effects of the three immunotoxins, they were given intraperitoneally to nude mice bearing subcutaneous A431 tumors. All three immunotoxins caused complete regression of 50-mm3 tumors with no toxic effects to the animals at therapeutic doses. Furthermore, substantial regression was also noted with much larger tumors. Our data indicate that the monoclonal antibody B3, when coupled to PE or recombinant forms of PE, may be useful for the treatment of tumors expressing B3 antigen. The therapeutic window was largest with B3-LysPE40, which can be administered in higher doses because it lacks sequences in domain I of PE that enable PE to bind to nontarget cells. C1 NCI,MOLEC BIOL LAB,9000 ROCKVILLE PIKE,37-4E16,BETHESDA,MD 20892. NR 13 TC 83 Z9 85 U1 0 U2 0 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR PY 1991 VL 88 IS 8 BP 3358 EP 3362 DI 10.1073/pnas.88.8.3358 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FG913 UT WOS:A1991FG91300082 PM 2014255 ER PT J AU WELLEMS, TE WALKERJONAH, A PANTON, LJ AF WELLEMS, TE WALKERJONAH, A PANTON, LJ TI GENETIC-MAPPING OF THE CHLOROQUINE-RESISTANCE LOCUS ON PLASMODIUM-FALCIPARUM CHROMOSOME-7 SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article ID HUMAN MALARIA PARASITE; HISTIDINE-RICH PROTEIN; AMINO-ACID-SEQUENCE; SURFACE-ANTIGEN; P-FALCIPARUM; IDENTIFICATION; AMPLIFICATION; ERYTHROCYTE; STAGE; MAP AB The resurgence of malaria in recent decades has been accompanied by the worldwide spread of resistance to chloroquine, a drug once uncontested as the first-line antimalarial agent because of its efficacy and low toxicity. Chloroquine-resistant strains of Plasmodium falciparum counter the drug by expelling it rapidly via an unknown mechanism. In the absence of explicit biochemical knowledge of this efflux mechanism, reverse genetics provides a powerful approach to the molecular basis of chloroquine resistance. Here we report genetic linkage analysis in which 85 restriction fragment length polymorphism markers were used to examine inheritance of the 14 P. falciparum chromosomes in a laboratory cross between a chloroquine-resistant and a chloroquine-sensitive parasite. Inheritance data from 16 independent recombinant progeny show that the rapid efflux, chloroquine-resistant phenotype is governed by a single locus within an almost-equal-to-400-kilobase region of chromosome 7. Identification and characterization of genes within this region should lead to an understanding of the chloroquine-resistance mechanism. RP WELLEMS, TE (reprint author), NIAID,PARASIT DIS LAB,BETHESDA,MD 20892, USA. NR 44 TC 249 Z9 258 U1 1 U2 3 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR PY 1991 VL 88 IS 8 BP 3382 EP 3386 DI 10.1073/pnas.88.8.3382 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FG913 UT WOS:A1991FG91300087 PM 1673031 ER PT J AU OGATA, N ALTER, HJ MILLER, RH PURCELL, RH AF OGATA, N ALTER, HJ MILLER, RH PURCELL, RH TI NUCLEOTIDE-SEQUENCE AND MUTATION-RATE OF THE H-STRAIN OF HEPATITIS-C VIRUS SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article ID NON-B-HEPATITIS; NON-A; EVOLUTION; GENOME AB Patient H is an American patient who was infected with hepatitis C virus (HCV) in 1977. The patient became chronically infected and has remained so for the past 13 years. In this study, we compared the nucleotide and predicted amino acid sequences of the HCV genome obtained from plasma collected in 1977 with that collected in 1990. We find that the two HCV isolates differ at 123 of the 4923 (2.50%) nucleotides sequenced. We estimate that the mutation rate of the H strain of HCV is almost-equal-to 1.92 x 10(-3) base substitutions per genome site per year. The nucleotide changes were exclusively base substitutions and were unevenly distributed throughout the genome. A relatively high rate of change was observed in the region of the HCV genome that corresponds to the nonstructural protein 1 gene region of flaviviruses, where 44 of 960 (4.6%) nucleotides were different. Within this region there was a 39-nucleotide domain in which 28.2% of the nucleotides differed between the two isolates. In contrast, relatively few nucleotide substitutions were observed in the 5' noncoding region, where only 2 of 276 (0.7%) nucleotides were different. Our results suggest that the mutation rate of the HCV genome is similar to that of other RNA viruses and that genes appear to be evolving at different rates within the virus genome. C1 NCI,WARREN G MAGNUSON CLIN CTR,DEPT TRANSFUS MED,BETHESDA,MD 20892. RP OGATA, N (reprint author), NIAID,INFECT DIS LAB,HEPATITIS VIRUSES SECT,BETHESDA,MD 20892, USA. NR 33 TC 484 Z9 493 U1 1 U2 3 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR PY 1991 VL 88 IS 8 BP 3392 EP 3396 DI 10.1073/pnas.88.8.3392 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FG913 UT WOS:A1991FG91300089 PM 1849654 ER PT J AU PARALKAR, VM HAMMONDS, RG REDDI, AH AF PARALKAR, VM HAMMONDS, RG REDDI, AH TI IDENTIFICATION AND CHARACTERIZATION OF CELLULAR-BINDING PROTEINS (RECEPTORS) FOR RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2B, AN INITIATOR OF BONE DIFFERENTIATION CASCADE SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE BONE CELLS; MORPHOGENESIS; CARTILAGE; DEVELOPMENT; TRANSFORMING GROWTH FACTOR-BETA SUPERFAMILY ID GROWTH FACTOR-BETA; HUMAN FIBROBLASTS; CULTURED-CELLS; 2 FORMS AB Bone morphogenetic protein 2B (BMP 2B), is a heparin-binding bone differentiation factor that initiates endochondral bone formation in rats when implanted subcutaneously. The molecular mechanism of action of this differentiation factor is not known, and as a first step we have examined BMP 2B-responsive cells for the presence of specific cellular binding proteins. Using I-125-labeled BMP 2B, specific high-affinity binding sites for recombinant human BMP 2B on MC3T3 E1 osteoblast-like cells as well as on NIH 3T3 fibroblasts were identified. Platelet-derived growth factor, insulin-like growth factor 1, basic fibroblast growth factor, epidermal growth factor, and transforming growth factor-beta did not compete for the binding of radiolabeled BMP 2B. The binding of BMP 2B is a time- and temperature-dependent process. Chemical crosslinking of radiolabeled BMP showed two components (apparent size, 200 and 70 kDa in MC3T3 E1 cells and 200 and 90 kDa in NIH 3T3 cells). A minor component at 60 kDa was also detected in both cell lines. Scatchard analysis of the binding data showed a high-affinity receptor with an apparent dissociation constant of 128 +/- 40 pM in MC3T3 E1 cells. These data demonstrate specific, high-affinity cell-surface binding proteins for BMP 2B. C1 NIDR,BONE CELL BIOL SECT,BETHESDA,MD 20892. GENENTECH INC,DEPT DEV BIOL,S SAN FRANCISCO,CA 94080. NR 29 TC 51 Z9 51 U1 0 U2 1 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR PY 1991 VL 88 IS 8 BP 3397 EP 3401 DI 10.1073/pnas.88.8.3397 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FG913 UT WOS:A1991FG91300090 PM 1849655 ER PT J AU RADOVICK, S WRAY, S LEE, E NICOLS, DK NAKAYAMA, Y WEINTRAUB, BD WESTPHAL, H CUTLER, GB WONDISFORD, FE AF RADOVICK, S WRAY, S LEE, E NICOLS, DK NAKAYAMA, Y WEINTRAUB, BD WESTPHAL, H CUTLER, GB WONDISFORD, FE TI MIGRATORY ARREST OF GONADOTROPIN-RELEASING-HORMONE NEURONS IN TRANSGENIC MICE SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE T-ANTIGEN; INFERTILITY; KALLMANN SYNDROME; HYPOGONADISM; HYPOTHALAMUS ID OLFACTORY PLACODE; MOUSE; ORIGIN; GENE AB Gonadotropin-releasing hormone (GnRH) is important in reproduction, although the mechanism of central hypogonadism in humans remains unclear. Because the GnRH neuron originates from the olfactory placode and migrates to the hypothalamus during development,central hypogonadism in humans could be caused by failure in normal migration of GnRH neurons to the hypothalamus. We report that in transgenic mice expression of the simian virus 40 T antigen, driven by the promoter of human GnRH gene, resulted in central hypogonadism due to an arrest in neuronal migration during development and tumor formation along the migratory pathway. This system appears to be an important animal model of hypogonadotropic hypogonadism in humans. Additionally, olfactory bulb tumors from these animals were dispersed, and a GnRH-secreting neuronal cell line (GN cell line) was established. C1 CASE WESTERN RESERVE UNIV,UNIV HOSP CLEVELAND,DEPT INTERNAL MED,CLEVELAND,OH 44106. CASE WESTERN RESERVE UNIV,UNIV HOSP CLEVELAND,DEPT PEDIAT,CLEVELAND,OH 44106. NICHHD,BETHESDA,MD 20892. NINCDS,BETHESDA,MD 20892. NCI,OFF RES SERV,BETHESDA,MD 20892. NIDDKD,BETHESDA,MD 20892. OI wray, susan/0000-0001-7670-3915 NR 11 TC 177 Z9 178 U1 1 U2 1 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR PY 1991 VL 88 IS 8 BP 3402 EP 3406 DI 10.1073/pnas.88.8.3402 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FG913 UT WOS:A1991FG91300091 PM 2014260 ER PT J AU ROBERTS, JD THOMAS, DC KUNKEL, TA AF ROBERTS, JD THOMAS, DC KUNKEL, TA TI EXONUCLEOLYTIC PROOFREADING OF LEADING AND LAGGING STRAND DNA-REPLICATION ERRORS SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article ID SIMIAN VIRUS-40 DNA; POLYMERASE-III HOLOENZYME; 5' EXONUCLEASE ACTIVITY; ESCHERICHIA-COLI; SELECTIVE-INHIBITION; INVITRO REPLICATION; MUTATOR GENE; FIDELITY; PURIFICATION; MUTAGENESIS AB We have asked whether exonucleolytic proofreading occurs during simian virus 40 origin-dependent, bidirectional DNA replication in extracts of human HeLa cells. In addition, we have compared the fidelity of leading and lagging strand DNA synthesis. In a fidelity assay that scores single-base substitution errors that revert a TGA codon in the lacZ-alpha gene in an M13mp vector, providing an excess of a single dNTP substrate over the other three dNTP substrates in a replication reaction generates defined, strand-specific errors. Fidelity measurements with two vectors having the origin of replication on opposite sides of the opal codon demonstrate that error rates for two different A.dCTP and T.dGTP mispairs increase when deoxyguanosine monophosphate is added to replication reaction mixtures or when the concentration of deoxynucleoside triphosphates is increased. The data suggest that exonucleolytic proofreading occurs on both strands during bidirectional replication. Measurements using the two simian virus 40 origin-containing vectors suggest that base substitution error rates are similar for replication of the leading and lagging strands. C1 NIEHS,MOLEC GENET LAB,RES TRIANGLE PK,NC 27709. NR 44 TC 62 Z9 62 U1 0 U2 0 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR PY 1991 VL 88 IS 8 BP 3465 EP 3469 DI 10.1073/pnas.88.8.3465 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FG913 UT WOS:A1991FG91300104 PM 1901658 ER PT J AU PELTON, JG TORCHIA, DA MEADOW, ND WONG, CY ROSEMAN, S AF PELTON, JG TORCHIA, DA MEADOW, ND WONG, CY ROSEMAN, S TI SECONDARY STRUCTURE OF THE PHOSPHOCARRIER PROTEIN-IIIGLC, A SIGNAL-TRANSDUCING PROTEIN FROM ESCHERICHIA-COLI, DETERMINED BY HETERONUCLEAR 3-DIMENSIONAL NMR-SPECTROSCOPY SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE PHOSPHOENOLPYRUVATE-GLYCOSE PHOSPHOTRANSFERASE SYSTEM; PHOSPHOHISTIDINE; TRIPLE RESONANCE ID BACTERIAL PHOSPHOTRANSFERASE SYSTEM; HISTIDINE-CONTAINING PROTEIN; NUCLEAR MAGNETIC-RESONANCE; TWO-DIMENSIONAL H-1-NMR; SUGAR-TRANSPORT; SALMONELLA-TYPHIMURIUM; TERTIARY STRUCTURE; HPR PROTEINS; PHOSPHOENOLPYRUVATE; PHOSPHORYLATION AB III(Glc) is a signal-transducing phosphocarrier protein of the phosphoenolpyruvate:glycose phosphotransferase system of Escherichia coli. The secondary structure of III(Glc) is determined by heteronuclear (N-15, C-13) three-dimensional NMR spectroscopy. Sequential, medium-range, and long-range nuclear Overhauser effects seen in NMR spectra are used to elucidate 11 antiparallel beta-strands and four helical segments. The medium-range nuclear Overhauser effect patterns suggest that the helices are either distorted alpha-helices or are of the 3(10) class. The amino acids separating the active-site histidine residues (His75 and His90) form two strands (Ala76-Ser81 and Val85-Phe91) of a six-stranded antiparallel beta-sheet that brings His90 and His75 in close proximity. Sequence similarities in III(Glc) and several other sugar-transport proteins suggest that the histidine residues within these proteins may be arranged in a similar manner. The 18-residue N-terminal peptide that precedes beta-strand Thr19-Ile22 in native III(Glc) is disordered and does not interact with the rest of the protein. Furthermore, removal of the N-terminal heptapeptide by a specific endopeptidase does not affect the structure of the remaining protein, thus explaining the phospho-acceptor activity of modified III(Glc) with the phospho-histidine-containing phosphocarrier protein of this system. C1 JOHNS HOPKINS UNIV,MCCOLLUM PRATT INST,BALTIMORE,MD 21218. JOHNS HOPKINS UNIV,DEPT BIOL,BALTIMORE,MD 21218. RP PELTON, JG (reprint author), NIDR,BONE RES BRANCH,BETHESDA,MD 20892, USA. FU NIGMS NIH HHS [GM38759] NR 33 TC 42 Z9 43 U1 0 U2 1 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR PY 1991 VL 88 IS 8 BP 3479 EP 3483 DI 10.1073/pnas.88.8.3479 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FG913 UT WOS:A1991FG91300107 PM 2014267 ER PT J AU KAHN, RS WETZLER, S ASNIS, GM KLING, MA SUCKOW, RF VANPRAAG, HM AF KAHN, RS WETZLER, S ASNIS, GM KLING, MA SUCKOW, RF VANPRAAG, HM TI PITUITARY-HORMONE RESPONSES TO META-CHLOROPHENYLPIPERAZINE IN PANIC DISORDER AND HEALTHY CONTROL SUBJECTS SO PSYCHIATRY RESEARCH LA English DT Article DE SEROTONIN; PANIC DISORDER; META-CHLOROPHENYLPIPERAZINE; ADRENOCORTICOTROPIC HORMONE; PROLACTIN ID SEROTONIN RECEPTOR HYPERSENSITIVITY; ANXIETY DISORDERS; NEURO-ENDOCRINE; CONSCIOUS RATS; AGONIST; BRAIN; CLOMIPRAMINE; ANTAGONISTS; ACTIVATION; RITANSERIN AB The present study reports adrenocorticotropic hormone (ACTH) and prolactin responses after oral administration of 0.25 mg/kg of the serotonin agonist, meta-chlorophenylpiperazine (MCPP), in patients with panic disorder (PD) and in healthy subjects. MCPP blood levels were similar for the two groups, but almost twice as high in males as in females. Female patients had augmented ACTH and prolactin release as compared to healthy females, while ACTH and prolactin release in male patients was similar to that of male controls. These results suggest that female PD patients have hypersensitive serotonin receptors. Moreover, they indicate that pharmacokinetic gender differences may affect challenge studies, and that different doses may be required to study neuroendocrine responses in males and females. C1 MONTEFIORE MED CTR,ALBERT EINSTEIN COLL MED,DEPT PSYCHIAT,BRONX,NY 10467. MONTEFIORE MED CTR,ALBERT EINSTEIN COLL MED,CLIN ASSESSMENT PROGRAM,BRONX,NY 10467. MONTEFIORE MED CTR,ALBERT EINSTEIN COLL MED,AFFECT DISORDERS CLIN,BRONX,NY 10467. NIMH,CLIN NEUROENDOCRINOL BRANCH,AFFECT DISORDERS UNIT,BETHESDA,MD 20892. COLUMBIA UNIV,DEPT ANALYT PSYCHOPHARMACOL,NEW YORK,NY 10027. RI Kling, Mitchel/F-4152-2010 OI Kling, Mitchel/0000-0002-2232-1409 NR 41 TC 38 Z9 38 U1 0 U2 0 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0165-1781 J9 PSYCHIAT RES JI Psychiatry Res. PD APR PY 1991 VL 37 IS 1 BP 25 EP 34 DI 10.1016/0165-1781(91)90103-V PG 10 WC Psychiatry SC Psychiatry GA FM329 UT WOS:A1991FM32900004 PM 1650487 ER PT J AU HAERTZEN, CA AF HAERTZEN, CA TI GEOPHYSICAL VARIABLES AND BEHAVIOR .65. SEASONAL-CHANGES IN MOOD IN OPIOID ADDICTS ON THE ADDICTION RESEARCH-CENTER INVENTORY SO PSYCHOLOGICAL REPORTS LA English DT Article RP HAERTZEN, CA (reprint author), NIDA,ADDICT RES CTR,POB 5180,BALTIMORE,MD 21224, USA. NR 7 TC 1 Z9 1 U1 0 U2 0 PU PSYCHOLOGICAL REPORTS PI MISSOULA PA P O BOX 9229, MISSOULA, MT 59807 SN 0033-2941 J9 PSYCHOL REP JI Psychol. Rep. PD APR PY 1991 VL 68 IS 2 BP 360 EP 362 PG 3 WC Psychology, Multidisciplinary SC Psychology GA FM953 UT WOS:A1991FM95300002 PM 1862167 ER PT J AU CABIB, E SILVERMAN, SJ SHAW, JA DASGUPTA, S PARK, HM MULLINS, JT MOL, PC BOWERS, B AF CABIB, E SILVERMAN, SJ SHAW, JA DASGUPTA, S PARK, HM MULLINS, JT MOL, PC BOWERS, B TI CARBOHYDRATES AS STRUCTURAL CONSTITUENTS OF YEAST-CELL WALL AND SEPTUM SO PURE AND APPLIED CHEMISTRY LA English DT Article ID SACCHAROMYCES-CEREVISIAE; CHITIN SYNTHESIS; BETA-(1->3)GLUCAN SYNTHETASE; GLUCAN SYNTHESIS; PAPULACANDIN-B; S-CEREVISIAE; ENZYME; BIOSYNTHESIS; SYNTHASE; PURIFICATION AB The cell walls and septa of fungi are useful models for morphogenesis and potential targets for antifungal agents. In the yeast, Saccharomyces cerevisiae, the main structural components of the primary septum and of the cell wall are chitin and beta(1-->3)glucan, respectively. Two chitin synthetases have been identified in yeast, one of which is essential for septum formation, whereas the other one has a repair function. Both synthetases are bound to the plasma membrane and are found in extracts in a zymogenic form that can be activated by proteases. beta(1-->3)glucan synthetase is also attached to the plasma membrane. Its activity is strongly stimulated by GTP and its analogs. By sequential extraction of the membranes, two components have been obtained in soluble form. One contains a GTP-binding protein; the other probably includes the substrate-binding site. Both components, in addition to GTP, are required for glucan synthesis. RP CABIB, E (reprint author), NATL INST DIABET & DIGEST & KIDNEY DIS,BETHESDA,MD 20892, USA. NR 33 TC 16 Z9 16 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0033-4545 J9 PURE APPL CHEM JI Pure Appl. Chem. PD APR PY 1991 VL 63 IS 4 BP 483 EP 489 DI 10.1351/pac199163040483 PG 7 WC Chemistry, Multidisciplinary SC Chemistry GA FD821 UT WOS:A1991FD82100004 ER PT J AU WOLFF, SD ENG, J BALABAN, RS AF WOLFF, SD ENG, J BALABAN, RS TI MAGNETIZATION TRANSFER CONTRAST - METHOD FOR IMPROVING CONTRAST IN GRADIENT-RECALLED-ECHO IMAGES SO RADIOLOGY LA English DT Article DE CEREBRAL BLOOD VESSELS, MR STUDIES; BRAIN, MR STUDIES; CEREBROSPINAL FLUID, MR STUDIES; MAGNETIC RESONANCE (MR), EXPERIMENTAL; MAGNETIC RESONANCE (MR), PHYSICS; MAGNETIC RESONANCE (MR), PULSE SEQUENCES; MAGNETIC RESONANCE (MR), SURFACE COILS; MAGNETIC RESONANCE (MR), TECHNOLOGY; MUSCLES, MR STUDIES ID INVIVO AB A method that improves contrast in gradient-recalled-echo magnetic resonance images is described. The increase in contrast is produced by applying low-power radio-frequency irradiation 5-10 kHz from the main water proton resonance frequency to excite macromolecular hydrogen-1 nuclei as part of a conventional gradient-recalled-echo sequence. The contrast so obtained is theoretically different from T1 or T2 contrast and has been termed magnetization transfer contrast. Cat head images were acquired in vivo with this method at 4.7 and 1.5 T. Compared with conventional gradient-recalled-echo images, the magnetization transfer images demonstrate increased contrast between many tissue pairs, such as between white matter and blood and between gray matter and cerebrospinal fluid. The dependence of the magnetization transfer effect on repetition time and preirradiation power were also studied. C1 NIH,CARDIAC ENERGET LAB,BLDG 1,RM B3-07,BETHESDA,MD 20892. RI Balaban, Robert/A-7459-2009 OI Balaban, Robert/0000-0003-4086-0948 NR 12 TC 124 Z9 125 U1 1 U2 3 PU RADIOLOGICAL SOC NORTH AMER PI EASTON PA 20TH AND NORTHAMPTON STS, EASTON, PA 18042 SN 0033-8419 J9 RADIOLOGY JI Radiology PD APR PY 1991 VL 179 IS 1 BP 133 EP 137 PG 5 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA FC883 UT WOS:A1991FC88300028 PM 2006263 ER PT J AU HENDLER, RW AF HENDLER, RW TI COMPUTER-CONTROLLED SYSTEM FOR THE REAL-TIME MEASUREMENTS OF MEMBRANE-POTENTIAL, INTERNAL AND EXTERNAL PHS, DELTA-PH, PROTON FLUXES, AND O-2 CONCENTRATION SO REVIEW OF SCIENTIFIC INSTRUMENTS LA English DT Article ID OXYGEN-UPTAKE; MOTIVE FORCE; MITOCHONDRIA; EXTRUSION AB The construction of sturdy ion-selective electrodes for tetraphenyl phosphonium ion (TPP+), and salicylate is described. Instrumentation and procedures are presented for real-time studies of membrane potentials and pH gradients that form across the membranes of organelles that are capable of transducing metabolic or radiant energy into an electrochemical potential for protons. The system is based on input signals from a TPP+-selective electrode, fluorescence from a pH-sensitive dye, a pH electrode, and an O2 electrode. A microcomputer is used to perform extensive computations based on the raw input data and to display various aspects of the progress of an experiment both on a CRT monitor and a recorder. RP HENDLER, RW (reprint author), NHLBI,CELL BIOL LAB,BETHESDA,MD 20892, USA. NR 7 TC 4 Z9 4 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0034-6748 J9 REV SCI INSTRUM JI Rev. Sci. Instrum. PD APR PY 1991 VL 62 IS 4 BP 1067 EP 1071 DI 10.1063/1.1142060 PG 5 WC Instruments & Instrumentation; Physics, Applied SC Instruments & Instrumentation; Physics GA FF017 UT WOS:A1991FF01700034 ER PT J AU HITCHCOCK, PJ WASSERHEIT, JN HARRIS, JR HOLMES, KK AF HITCHCOCK, PJ WASSERHEIT, JN HARRIS, JR HOLMES, KK TI SEXUALLY-TRANSMITTED DISEASES IN THE AIDS ERA - DEVELOPMENT OF STD DIAGNOSTICS FOR RESOURCE-LIMITED SETTINGS IS A GLOBAL PRIORITY SO SEXUALLY TRANSMITTED DISEASES LA English DT Article C1 US AGCY INT DEV,SEXUALLY TRANSMITTED DIS BRANCH,WASHINGTON,DC 20523. UNIV WASHINGTON,CTR AIDS & STD,SEATTLE,WA 98195. RP HITCHCOCK, PJ (reprint author), NIAID,SEXUALLY TRANSMITTED DIS BRANCH,WESTWOOD BLDG,ROOM 749,BETHESDA,MD 20892, USA. OI Harris, Jeffrey/0000-0001-8728-7195 NR 4 TC 6 Z9 6 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0148-5717 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD APR-JUN PY 1991 VL 18 IS 2 BP 133 EP 135 PG 3 WC Infectious Diseases SC Infectious Diseases GA FM722 UT WOS:A1991FM72200016 PM 1677786 ER PT J AU BYAR, DP AF BYAR, DP TI PROBLEMS WITH USING OBSERVATIONAL DATABASES TO COMPARE TREATMENTS SO STATISTICS IN MEDICINE LA English DT Article; Proceedings Paper CT 3RD BIENNIAL REGENSTRIEF CONF ON METHODS FOR USING LARGE DATABASES IN HEALTH CARE RESEARCH : PROBLEMS AND PROMISES CY OCT 23-25, 1989 CL TURKEY RUN STATE PARK, IN SP REGENSTRIEF INST HLTH CARE, ELI LILLY & CO, DIABETES RES & TRAINING CTR, UPJOHN, JOHN WILEY & SONS, HOFFMANN LA ROCHE RP BYAR, DP (reprint author), NIH,BETHESDA,MD 20892, USA. NR 0 TC 82 Z9 82 U1 0 U2 5 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0277-6715 J9 STAT MED JI Stat. Med. PD APR PY 1991 VL 10 IS 4 BP 663 EP 666 DI 10.1002/sim.4780100417 PG 4 WC Mathematical & Computational Biology; Public, Environmental & Occupational Health; Medical Informatics; Medicine, Research & Experimental; Statistics & Probability SC Mathematical & Computational Biology; Public, Environmental & Occupational Health; Medical Informatics; Research & Experimental Medicine; Mathematics GA FG070 UT WOS:A1991FG07000015 PM 2057663 ER PT J AU CHAPIN, RE PHELPS, JL BURKA, LT ABOUDONIA, MB HEINDEL, JJ AF CHAPIN, RE PHELPS, JL BURKA, LT ABOUDONIA, MB HEINDEL, JJ TI THE EFFECTS OF TRI-ORTHO-CRESYL PHOSPHATE AND METABOLITES ON RAT SERTOLI-CELL FUNCTION IN PRIMARY CULTURE SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article ID INDUCED DELAYED NEUROTOXICITY; INVITRO PHOSPHORYLATION; PROTEIN-SYNTHESIS; HEN BRAIN; LACTATE; CYTOCHROME-P-450; MICROTUBULES; INHIBITION; ESTERASES; CALCIUM C1 NIEHS,CHEM DISPOSIT GRP,RES TRIANGLE PK,NC 27709. DUKE UNIV,MED CTR,DEPT PHARMACOL,DURHAM,NC 27710. RP CHAPIN, RE (reprint author), NIEHS,DEV & REPROD TOXICOL GRP,POB 12233,RES TRIANGLE PK,NC 27709, USA. OI Chapin, Robert/0000-0002-5997-1261 NR 40 TC 10 Z9 10 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0041-008X J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD APR PY 1991 VL 108 IS 2 BP 194 EP 204 DI 10.1016/0041-008X(91)90110-Z PG 11 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA FG044 UT WOS:A1991FG04400002 PM 1902005 ER PT J AU LUBET, RA JONES, CR STOCKUS, DL FOX, SD NIMS, RW AF LUBET, RA JONES, CR STOCKUS, DL FOX, SD NIMS, RW TI INDUCTION OF CYTOCHROME-P450 AND OTHER DRUG-METABOLIZING-ENZYMES IN RAT-LIVER FOLLOWING DIETARY EXPOSURE TO AROCLOR-1254 SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article ID POLYCHLORINATED BIPHENYL CONGENERS; GLUTATHIONE S-TRANSFERASES; EPOXIDE HYDROLASE; ALDEHYDE DEHYDROGENASE; AROMATIC-HYDROCARBONS; NUCLEOTIDE-SEQUENCE; FLUOROMETRIC ASSAY; ISOZYMES; DEALKYLATION; INDUCERS C1 NCI,FREDERICK CANC RES & DEV CTR,PRI DYNCORP,FREDERICK,MD 21702. RP LUBET, RA (reprint author), NCI,FREDERICK CANC RES & DEV CTR,COMPARAT CARCINOGENESIS LAB,BLDG 538,ROOM 205E,FREDERICK,MD 21702, USA. FU NCI NIH HHS [N01-CO-74102] NR 50 TC 37 Z9 37 U1 1 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0041-008X J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD APR PY 1991 VL 108 IS 2 BP 355 EP 365 DI 10.1016/0041-008X(91)90124-W PG 11 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA FG044 UT WOS:A1991FG04400016 PM 1902007 ER PT J AU GUZZETTA, PC SUNDT, TM SUZUKI, T MIXON, A ROSENGARD, BR SACHS, DH AF GUZZETTA, PC SUNDT, TM SUZUKI, T MIXON, A ROSENGARD, BR SACHS, DH TI INDUCTION OF KIDNEY-TRANSPLANTATION TOLERANCE ACROSS MAJOR HISTOCOMPATIBILITY COMPLEX BARRIERS BY BONE-MARROW TRANSPLANTATION IN MINIATURE SWINE SO TRANSPLANTATION LA English DT Article ID POSTTRANSPLANT ANTITHYMOCYTE GLOBULIN; INCOMPATIBLE ALLOGRAFT ACCEPTANCE; T-CELL DEPLETION; ALLOGENEIC UNRESPONSIVENESS; MONOCLONAL-ANTIBODIES; RADIATION CHIMERAS; RENAL-ALLOGRAFTS; RHESUS-MONKEYS; SURVIVAL; DOGS AB Previous studies from our laboratory have shown that permanent lymphohematopoietic chimerism can be induced in MHC-disparate miniature swine by bone marrow transplantation after lethal total-body irradiation. The purpose of the present study was to determine in this large animal model whether such chimerism would lead to permanent tolerance to a vascularized allograft without a requirement for exogenous immunosuppression. Eight miniature swine that had received MHC-mismatched BMT more than five months earlier under-went kidney transplantation (KTx) from a donor MHC matched (n = 5) or MHC mismatched (n = 3) with the BMT donor. All animals had regained in vitro responsiveness to third-party MHC antigens, as measured by mixed lymphocyte reaction (MLR), before KTx but remained nonresponsive to MHC antigens of the BMT donor and self. All three animals that received KTx mismatched for BMT donor MHC rejected promptly (mean survival time 7.0 days). Of the five animals that received KTx matched for BMT donor MHC, four showed no evidence of rejection and have functioning KTx > 200 days after KTx. The fifth animal had excellent renal function for 60 days but then developed a slowly rising BUN and serum creatinin, and died 75 days after KTx. The course of this animal's rejection is consistent with that previously described for rejection due to minor antigen disparities. The difference in survival of KTx matched or mismatched for the MHC of the BMT donor was statistically significant (P = 0.0062). The survival of KTx matched for the MHC of the BMT donor was significantly different from that of control animals without BMT receiving KTx mismatched for MHC (P = 0.0018). We therefore conclude that BMT is an effective means for induction of tolerance to an MHC mismatched KTx in this large animal model. C1 NCI,IMMUNOL BRANCH,BETHESDA,MD 20892. NR 29 TC 34 Z9 35 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0041-1337 J9 TRANSPLANTATION JI Transplantation PD APR PY 1991 VL 51 IS 4 BP 862 EP 866 DI 10.1097/00007890-199104000-00024 PG 5 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA FH380 UT WOS:A1991FH38000024 PM 2014544 ER PT J AU CUMMINGS, NB AF CUMMINGS, NB TI ALLOCATION OF SCARCE RESOURCES - THE TRANSPLANTATION EXPERIENCE SO TRANSPLANTATION PROCEEDINGS LA English DT Article; Proceedings Paper CT 2ND PAN-AMERICAN CONGRESS FOR DIALYSIS AND TRANSPLANTATION CY NOV 16-19, 1989 CL SAN JUAN, PR RP CUMMINGS, NB (reprint author), NIDDK,9A18,BLDG 31,9000 ROCKVILLE PIKE,BETHESDA,MD 20892, USA. NR 11 TC 2 Z9 2 U1 1 U2 2 PU APPLETON & LANGE PI E NORWALK PA 25 VAN ZANT ST, E NORWALK, CT 06855 SN 0041-1345 J9 TRANSPLANT P JI Transplant. Proc. PD APR PY 1991 VL 23 IS 2 BP 1791 EP 1794 PG 4 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA FG566 UT WOS:A1991FG56600024 PM 2053157 ER PT J AU COPELAND, NG JENKINS, NA AF COPELAND, NG JENKINS, NA TI DEVELOPMENT AND APPLICATIONS OF A MOLECULAR GENETIC-LINKAGE MAP OF THE MOUSE GENOME SO TRENDS IN GENETICS LA English DT Review ID POLYMERASE CHAIN-REACTION; MURINE LEUKEMIA-VIRUS; INTERSPECIFIC CROSSES; TRANSGENIC MOUSE; X-CHROMOSOME; MUTATION; RECOMBINATION; AMPLIFICATION; LOCALIZATION; MUTAGENESIS AB Interspecific mouse backcrosses provide almost limitless genetic variation for gene mapping. We have used interspecific backcrosses to develop the first comprehensive molecular genetic linkage map of the mouse genome. More than 600 loci have been positioned on the map; the current average map resolution is less than 3 cM. Since all loci were mapped using a single backcross panel, gene order can be determined unambiguously. With this level of resolution, it is now possible to position any new locus on the linkage map with virtually 100% certainty. In this article, we review how interspecific linkage maps are constructed, the salient features of our linkage map, and some of the many applications of interspecific linkage maps, in general, for future research. RP COPELAND, NG (reprint author), NCI,FREDERICK CANC RES & DEV CTR,MAMMALIAN GENET LAB,ABL BASIC RES PROGRAM,FREDERICK,MD 21702, USA. FU NCI NIH HHS [N01-CO-74101] NR 54 TC 544 Z9 544 U1 1 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0168-9525 J9 TRENDS GENET JI Trends Genet. PD APR PY 1991 VL 7 IS 4 BP 113 EP 118 DI 10.1016/0168-9525(91)90085-5 PG 6 WC Genetics & Heredity SC Genetics & Heredity GA FE688 UT WOS:A1991FE68800006 PM 2068781 ER PT J AU HENRICKSON, KJ KINGSBURY, DW VANWYKECOELINGH, KL NAEVE, CW PORTNER, A AF HENRICKSON, KJ KINGSBURY, DW VANWYKECOELINGH, KL NAEVE, CW PORTNER, A TI NEUTRALIZING EPITOPES OF HUMAN PARAINFLUENZA VIRUS TYPE-3 ARE CONFORMATIONAL AND CANNOT BE IMITATED BY SYNTHETIC PEPTIDES SO VACCINE LA English DT Article DE PIV-3; HN; SYNTHETIC PEPTIDES; EPITOPES ID HEMAGGLUTININ-NEURAMINIDASE GLYCOPROTEIN; RESPIRATORY SYNCYTIAL VIRUS; AMINO-ACID SEQUENCE; PARA-INFLUENZA; MONOCLONAL-ANTIBODIES; LARGE NUMBERS; PROTEIN; INFECTION; BINDING; REINFECTION AB The possibility that linear epitopes on the haemagglutinin-neuraminidase (HN) surface glycoprotein of human parainfluenza virus type 3 (PIV-3) might induce neutralizing antibodies after virus infection was investigated. Thirty-seven peptides, representing 64% of the extramembranous portion of the HN molecule of PIV-3, were synthesized. Their ability to bind to 14 neutralizing murine monoclonal antibodies (mAbs) specific for HN or 26 high-titre human serum samples were tested in a direct enzyme-linked immunosorbent assay (ELISA) and in an indirect competition ELISA. None of the synthetic peptides reacted with any of the mAbs or serum samples in the direct test and none of 11 synthetic peptides tested blocked mAbs from binding to HN in the competition ELISA. These findings suggest that synthetic peptides cannot be used to imitate the known neutralizing epitopes on the HN. Analyses of reduced and non-reduced HN in ELISA and immunoblot assays confirmed that protein folding and tertiary structure are essential for epitope formation in these neutralizing sites. However, some children's sera analysed by immunoblotting contained antibodies to an uncharacterized linear epitope(s) not recognized by our panel of mAbs, raising the possibility that a neutralizing linear epitope does exist on the HN of PIV-3. C1 ST JUDE CHILDRENS RES HOSP, DEPT INFECT DIS, MEMPHIS, TN 38101 USA. ST JUDE CHILDRENS RES HOSP, DEPT VIROL & MOLEC BIOL, MEMPHIS, TN 38101 USA. NIAID, INFECT DIS LAB, BETHESDA, MD 20892 USA. FU NCI NIH HHS [CA-09346-09, CA-21765-12] NR 36 TC 11 Z9 11 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD APR PY 1991 VL 9 IS 4 BP 243 EP 249 DI 10.1016/0264-410X(91)90107-H PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA FF564 UT WOS:A1991FF56400006 PM 1711742 ER PT J AU KHLEIF, SN MYERS, T CARTER, BJ TREMPE, JP AF KHLEIF, SN MYERS, T CARTER, BJ TREMPE, JP TI INHIBITION OF CELLULAR-TRANSFORMATION BY THE ADENOASSOCIATED VIRUS REP GENE SO VIROLOGY LA English DT Note ID HAMSTER-CELLS; DNA-SYNTHESIS; EXPRESSION; REPLICATION; SV40; AMPLIFICATION; ONCOGENICITY; PROTEINS; INVITRO; MUTANTS C1 MED COLL OHIO,DEPT BIOCHEM & MOLEC BIOL,TOLEDO,OH 43699. NIDDKD,MOLEC & CELLULAR BIOL LAB,BETHESDA,MD 20892. NR 29 TC 80 Z9 80 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0042-6822 J9 VIROLOGY JI Virology PD APR PY 1991 VL 181 IS 2 BP 738 EP 741 DI 10.1016/0042-6822(91)90909-U PG 4 WC Virology SC Virology GA FB496 UT WOS:A1991FB49600035 PM 1849683 ER PT J AU BURKE, RL HARTOG, K CROEN, KD OSTROVE, JM AF BURKE, RL HARTOG, K CROEN, KD OSTROVE, JM TI DETECTION AND CHARACTERIZATION OF LATENT HSV RNA BY INSITU AND NORTHERN BLOT HYBRIDIZATION IN GUINEA-PIGS SO VIROLOGY LA English DT Note ID HERPES-SIMPLEX VIRUS; HUMAN TRIGEMINAL GANGLIA; GENITAL HERPES; TYPE-1 TRANSCRIPTS; INFECTED NEURONS; ESTABLISHMENT; STATE; MICE C1 NIAID,MED VIROL SECT,BETHESDA,MD 20892. RP BURKE, RL (reprint author), CHIRON CORP,EMERYVILLE,CA 94613, USA. NR 26 TC 26 Z9 26 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0042-6822 J9 VIROLOGY JI Virology PD APR PY 1991 VL 181 IS 2 BP 793 EP 797 PG 5 WC Virology SC Virology GA FB496 UT WOS:A1991FB49600046 PM 1849688 ER PT J AU TABOR, E EPSTEIN, JS HEWLETT, IK LEE, SF AF TABOR, E EPSTEIN, JS HEWLETT, IK LEE, SF TI INHIBITION BY DESFERRIOXAMINE OF INVITRO REPLICATION OF HIV-1 SO LANCET LA English DT Letter ID CELL-LINES; DEFEROXAMINE C1 US FDA,CTR BIOL EVALUAT & RES,BETHESDA,MD 20014. RP TABOR, E (reprint author), NCI,BETHESDA,MD 20892, USA. NR 7 TC 16 Z9 16 U1 0 U2 0 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0140-6736 J9 LANCET JI Lancet PD MAR 30 PY 1991 VL 337 IS 8744 BP 795 EP 795 DI 10.1016/0140-6736(91)91416-R PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA FD884 UT WOS:A1991FD88400040 PM 1672418 ER PT J AU CAI, D BEN, T DE LUCA, LM AF CAI, D BEN, T DE LUCA, LM TI RETINOIDS INDUCE TISSUE TRANSGLUTAMINASE IN NIH-3T3 CELLS SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS LA English DT Article ID TRANSFORMED MOUSE FIBROBLASTS; EPIDERMAL TRANSGLUTAMINASE; GENE-EXPRESSION; ACID; DIFFERENTIATION; FIBRONECTIN; ATTACHMENT; PROTEINS; SURFACE; LAMININ RP CAI, D (reprint author), NCI, CELLULAR CARCINOGENESIS & TUMOR PROMOT LAB, BETHESDA, MD 20892 USA. NR 30 TC 44 Z9 44 U1 0 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0006-291X J9 BIOCHEM BIOPH RES CO JI Biochem. Biophys. Res. Commun. PD MAR 29 PY 1991 VL 175 IS 3 BP 1119 EP 1124 DI 10.1016/0006-291X(91)91681-2 PG 6 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA FE403 UT WOS:A1991FE40300055 PM 1673838 ER PT J AU GATIGNOL, A BUCKLERWHITE, A BERKHOUT, B JEANG, KT AF GATIGNOL, A BUCKLERWHITE, A BERKHOUT, B JEANG, KT TI CHARACTERIZATION OF A HUMAN TAR RNA-BINDING PROTEIN THAT ACTIVATES THE HIV-1 LTR SO SCIENCE LA English DT Article ID HUMAN IMMUNODEFICIENCY VIRUS; LONG TERMINAL REPEAT; TRANS-ACTIVATION; MESSENGER-RNA; TRANSCRIPTIONAL ACTIVATION; REGULATORY SEQUENCES; RESPONSIVE REGION; MOLECULAR-CLONING; GENE-PRODUCT; EXPRESSION AB Human immunodeficiency virus type 1 (HIV-1) gene expression is activated by Tat, a virally encoded protein. Tat trans-activation requires viral (trans-activation-responsive; TAR) RNA sequences located in the R region of the long terminal repeat (LTR). Existing evidence suggests that Tat probably cooperates with cellular factors that bind to TAR RNA in the overall trans-activation process. A HeLa complementary DNA was isolated and characterized that encodes a TAR RNA-binding protein (TRBP). TRBP activated the HIV-1 LTR and was synergistic with Tat function. C1 NIAID,MOLEC MICROBIOL LAB,BETHESDA,MD 20892. RI Jeang, Kuan-Teh/A-2424-2008 NR 50 TC 311 Z9 320 U1 2 U2 9 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 SN 0036-8075 J9 SCIENCE JI Science PD MAR 29 PY 1991 VL 251 IS 5001 BP 1597 EP 1600 DI 10.1126/science.2011739 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FD890 UT WOS:A1991FD89000033 PM 2011739 ER PT J AU LOBOS, E WEISS, N KARAM, M TAYLOR, HR OTTESEN, EA NUTMAN, TB AF LOBOS, E WEISS, N KARAM, M TAYLOR, HR OTTESEN, EA NUTMAN, TB TI AN IMMUNOGENIC ONCHOCERCA-VOLVULUS ANTIGEN - A SPECIFIC AND EARLY MARKER OF INFECTION SO SCIENCE LA English DT Article ID MALTOSE-BINDING-PROTEIN; ESCHERICHIA-COLI; SEQUENCE AB Onchocerciasis (river blindness) is a serious health problem and a severe obstacle to social and economic development, especially in Africa. A complementary DNA fragment coding for an Onchocerca volvulus antigen (OV-16) was cloned and expressed in the plasmid vector pCG808fx. Immune responses to this O. volvulus-specific recombinant antigen were detectable in patients with documented onchocerciasis; the antibody response was also detectable at 3 months and at more than 1 year before infection could otherwise be detected in humans and in chimpanzees experimentally infected with O. volvulus third-stage larvae. C1 JOHNS HOPKINS UNIV,WILMER OPHTHALMOL INST,BALTIMORE,MD 21205. JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,BALTIMORE,MD 21205. SWISS TROP INST,CH-4051 BASEL,SWITZERLAND. WHO,ONCHOCERCIASIS CONTROL PROGRAMME,OUAGADOUGOU,BURKINA FASO. RP LOBOS, E (reprint author), NIAID,PARASIT DIS LAB,BLDG 4,ROOM 126,BETHESDA,MD 20892, USA. OI Taylor, Hugh/0000-0002-9437-784X NR 18 TC 94 Z9 94 U1 0 U2 4 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 SN 0036-8075 J9 SCIENCE JI Science PD MAR 29 PY 1991 VL 251 IS 5001 BP 1603 EP 1605 DI 10.1126/science.2011741 PG 3 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FD890 UT WOS:A1991FD89000035 PM 2011741 ER PT J AU ROSSOUW, JE LEWIS, B RIFKIND, BM AF ROSSOUW, JE LEWIS, B RIFKIND, BM TI MORTALITY EXPERIENCE IN CHOLESTEROL-REDUCTION TRIALS - REPLY SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter C1 ST THOMAS HOSP,LONDON SE1 7EH,ENGLAND. RP ROSSOUW, JE (reprint author), NHLBI,BETHESDA,MD 20892, USA. NR 5 TC 1 Z9 1 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD MAR 28 PY 1991 VL 324 IS 13 BP 923 EP 923 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA FD111 UT WOS:A1991FD11100020 ER PT J AU GLASSER, SP CLARK, PI LIPICKY, RJ HUBBARD, JM YUSUF, S AF GLASSER, SP CLARK, PI LIPICKY, RJ HUBBARD, JM YUSUF, S TI EXPOSING PATIENTS WITH CHRONIC, STABLE, EXERTIONAL ANGINA TO PLACEBO PERIODS IN DRUG TRIALS SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID CLINICAL-TRIALS AB Because the safety of withholding standard therapy and enrolling patients with stable angina in placebo-controlled trials is not known, we identified all events leading to dropout from trials of 12 antianginal drugs submitted in support of new drug applications to the US Food and Drug Administration. Persons who dropped out of the trials were classified as cause due to adverse cardiovascular events or other causes without knowledge of drug assignment. There were 3161 subjects who entered any randomized, double-blind phase of placebo-controlled protocols; 197 (6.2%) withdrew because of cardiovascular events. There was no difference in risk of adverse events between drug and placebo groups. A prospectively defined subgroup analysis showed that groups who received calcium antagonists were at an increased risk of dropout compared with placebo groups (P = .04), primarily because of a disproportionate number of adverse events in studies of one drug. In conclusion, there were few adverse experiences associated with short-term placebo use. Withholding active treatment does not increase the risk of serious cardiac events. C1 UNIV S FLORIDA,COLL MED,MDC BOX 19,TAMPA,FL 33612. JAMES A HALEY VET ADM MED CTR,TAMPA,FL 33612. US FDA,ROCKVILLE,MD 20857. NHLBI,BETHESDA,MD 20892. NR 16 TC 46 Z9 46 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD MAR 27 PY 1991 VL 265 IS 12 BP 1550 EP 1554 DI 10.1001/jama.265.12.1550 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA FC604 UT WOS:A1991FC60400030 PM 1671885 ER PT J AU DUBNER, R AF DUBNER, R TI NEURAL BASIS OF ORAL-FACIAL FUNCTION AND PAIN A CITATION-CLASSIC COMMENTARY ON THE NEURAL BASIS OF ORAL AND FACIAL FUNCTION BY DUBNER,R., SESSLE,B.J., AND STOREY,A.T. AND NEURONS THAT SUBSERVE THE SENSORY-DISCRIMINATIVE ASPECTS OF PAIN BY PRICE,D.D., AND DUBNER,R. SO CURRENT CONTENTS/CLINICAL MEDICINE LA English DT Article ID MEDULLARY DORSAL HORN; RESPONSES; STIMULI; MONKEY RP DUBNER, R (reprint author), NIDR,NEUROBIOL & ANESTHESIOL BRANCH,BETHESDA,MD 20892, USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU INST SCI INFORM INC PI PHILADELPHIA PA 3501 MARKET ST, PHILADELPHIA, PA 19104 SN 0891-3358 J9 CC/CLIN MED PD MAR 25 PY 1991 IS 12 BP 8 EP 8 PG 1 WC Multidisciplinary Sciences; Social Sciences, Interdisciplinary SC Science & Technology - Other Topics; Social Sciences - Other Topics GA FA583 UT WOS:A1991FA58300001 ER PT J AU DUBNER, R AF DUBNER, R TI NEURAL BASIS OF ORAL-FACIAL FUNCTION AND PAIN A CITATION-CLASSIC COMMENTARY ON THE NEURAL BASIS OF ORAL AND FACIAL FUNCTION BY DUBNER,R., SESSLE,B.J., AND STOREY,A.T. AND NEURONS THAT SUBSERVE THE SENSORY-DISCRIMINATIVE ASPECTS OF PAIN BY PRICE,D.D., AND DUBNER,R. SO CURRENT CONTENTS/LIFE SCIENCES LA English DT Article ID MEDULLARY DORSAL HORN; RESPONSES; STIMULI; MONKEY RP DUBNER, R (reprint author), NIDR,NEUROBIOL & ANESTHESIOL BRANCH,BETHESDA,MD 20892, USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU INST SCI INFORM INC PI PHILADELPHIA PA 3501 MARKET ST, PHILADELPHIA, PA 19104 SN 0011-3409 J9 CC/LIFE SCI PD MAR 25 PY 1991 IS 12 BP 8 EP 8 PG 1 WC Multidisciplinary Sciences; Social Sciences, Interdisciplinary SC Science & Technology - Other Topics; Social Sciences - Other Topics GA FA584 UT WOS:A1991FA58400001 ER PT J AU WONDRAK, EM LOUIS, JM OROSZLAN, S AF WONDRAK, EM LOUIS, JM OROSZLAN, S TI THE EFFECT OF SALT ON THE MICHAELIS MENTEN CONSTANT OF THE HIV-1 PROTEASE CORRELATES WITH THE HOFMEISTER SERIES SO FEBS LETTERS LA English DT Article DE HIV-1 PROTEASE; ENZYME KINETICS; SALT EFFECT; HOFMEISTER SERIES ID RETROVIRAL PROTEASES; RESOLUTION; GENE AB The effect of different types of salt on the proteolytic activity of HIV-1 protease was studied. At a similar ionic strength, the enzyme activity changed according to the salting out effect of the ions used (Hofmeiser series). Kinetic studies showed that a stronger salting out effect of the ions rather than the higher ionic strength per se increased the affinity to the substrate (K(m)) but in general did not alter the K(cat) value. C1 NCI, DIV CANC BIOL & DIAG, BETHESDA, MD 20892 USA. RP WONDRAK, EM (reprint author), NCI, FREDERICK CANC RES & DEV CTR, MOLEC VIROL & CARCINOGENESIS LAB, ABL BASIC RES PROGRAM, POB B, FREDERICK, MD 21702 USA. FU NCI NIH HHS [N01-CO-74101] NR 19 TC 63 Z9 63 U1 0 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0014-5793 EI 1873-3468 J9 FEBS LETT JI FEBS Lett. PD MAR 25 PY 1991 VL 280 IS 2 BP 344 EP 346 DI 10.1016/0014-5793(91)80327-Y PG 3 WC Biochemistry & Molecular Biology; Biophysics; Cell Biology SC Biochemistry & Molecular Biology; Biophysics; Cell Biology GA FF155 UT WOS:A1991FF15500038 PM 2013335 ER PT J AU WONDRAK, EM LOUIS, JM MORA, PT OROSZLAN, S AF WONDRAK, EM LOUIS, JM MORA, PT OROSZLAN, S TI PURIFICATION OF HIV-1 WILD-TYPE PROTEASE AND CHARACTERIZATION OF PROTEOLYTICALLY INACTIVE HIV-1 PROTEASE MUTANTS BY PEPSTATIN-A AFFINITY-CHROMATOGRAPHY SO FEBS LETTERS LA English DT Article DE HIV-1 PROTEASE; MUTANT PROTEASE; PEPSTATIN-A AFFINITY CHROMATOGRAPHY ID IMMUNODEFICIENCY VIRUS PROTEASE; RETROVIRAL PROTEASES; ASPARTIC PROTEINASES; CHEMICAL SYNTHESIS; RESOLUTION; EXPRESSION; INHIBITOR; HOMOLOGY; GENE AB Recombinant wild-type protease of human immunodeficiency virus, type 1 (HIV-1) expressed in E. coli was purified by pepstatin A affinity chromatography. An 88-fold purification was achieved giving a protease preparation with a specific enzymatic activity of approximately 3700 pmol/min/mu-g. Two proteolytically inactive HIV-1 mutant proteases (Arg-87 --> Lys; Asn-88 --> Glu) were found to bind to pepstatin A agarose, and they were purified as the wild-type protease. A third mutant protease (Arg-87 --> Glu) was apparently unable to bind to pepstatin A under similar conditions. Binding to pepstatin A indicates the binding ability of the substrate binding site and the ability to form dimers. These features may be used to purify and to characterize other mutated HIV-1 proteases. C1 NCI, DIV CANC BIOL & DIAG, BETHESDA, MD 20892 USA. RP WONDRAK, EM (reprint author), NCI, FREDERICK CANC RES & DEV CTR, ABL BASIC RES PROGRAM, MOLEC VIROL & CARCINOGENESIS LAB, POB B, FREDERICK, MD 21702 USA. FU NCI NIH HHS [N01-CO-74101] NR 27 TC 13 Z9 13 U1 2 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0014-5793 EI 1873-3468 J9 FEBS LETT JI FEBS Lett. PD MAR 25 PY 1991 VL 280 IS 2 BP 347 EP 350 DI 10.1016/0014-5793(91)80328-Z PG 4 WC Biochemistry & Molecular Biology; Biophysics; Cell Biology SC Biochemistry & Molecular Biology; Biophysics; Cell Biology GA FF155 UT WOS:A1991FF15500039 PM 2013336 ER PT J AU ARORA, KK FILBURN, CR PEDERSEN, PL AF ARORA, KK FILBURN, CR PEDERSEN, PL TI GLUCOSE PHOSPHORYLATION - SITE-DIRECTED MUTATIONS WHICH IMPAIR THE CATALYTIC FUNCTION OF HEXOKINASE SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Note ID RAT-BRAIN HEXOKINASE; AMINO-ACID SEQUENCE; MITOCHONDRIAL BOUND HEXOKINASE; YEAST HEXOKINASE; BINDING-SITE; TERMINAL HALVES; CLONED CDNA; TUMOR; METABOLISM; RESOLUTION AB Recent studies from this and other laboratories have resulted in the cloning and sequencing of hexokinases from a variety of tissues including yeast, human kidney, rat brain, rat liver, and mouse hepatoma. Significantly, studies on the hepatoma enzyme conducted in this laboratory (Arora, K. K., Fanciulli, M., and Pedersen, P. L. (1990) J. Biol. Chem. 265, 6481-6488) resulted also in its overexpression in Escherichia coli in active form. We have now used site-directed mutagenesis for the first time in studies of hexokinase to evaluate the role of amino acid residues predicted to interact with either glucose or ATP. Four amino acid residues (Ser-603, Asp-657, Glu-708, and Glu-742) believed to interact with glucose were mutated to alanine or glycine, whereas a lysine residue (Lys-558) thought to be directly involved in binding ATP was mutated to either methionine or arginine. Of all the mutations in residues believed to interact with glucose, the Asp-657 --> Ala mutation is the most profound, reducing the hexokinase activity to a level < 1% of the wild type. The relative V(max) values for Ser-603 --> Ala, Glu-708 --> Ala, and Glu-742 --> Ala enzymes are 6, 10, and 6.5%, respectively, of the wild-type enzyme. Glu-708 and Glu-742 mutations increase the apparent K(m) for glucose 50- and 14-fold, respectively, while the Ser-603 --> Ala mutation decreases the apparent K(m) for glucose 5-fold. At the putative ATP binding site, the relative V(max) for Lys-558 --> Arg and Lys-558 --> Met enzymes are 70 and 29%, respectively, of the wild-type enzyme with no changes in apparent K(m) for glucose. No changes were observed in the apparent K(m) for ATP with any mutation. These results support the view that all 4 residues predicted to interact with glucose from earlier x-ray studies may play a role in binding and/or catalysis. The Asp-657 and Ser-603 residues may be involved in both, while Glu-708 and Glu-742 clearly contribute to binding but are not essential for catalysis. In contrast, Lys-558 appears to be essential neither for binding nor catalysis. C1 JOHNS HOPKINS UNIV,SCH MED,DEPT BIOL CHEM,MOLEC & CELLULAR BIOENERGET LAB,BALTIMORE,MD 21205. NIA,GERONTOL RES CTR,BIOL CHEM LAB,BALTIMORE,MD 21224. FU NCI NIH HHS [CA 32742] NR 25 TC 59 Z9 60 U1 0 U2 1 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD MAR 25 PY 1991 VL 266 IS 9 BP 5359 EP 5362 PG 4 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA FD370 UT WOS:A1991FD37000002 PM 2005085 ER PT J AU SIMONDS, WF BUTRYNSKI, JE GAUTAM, N UNSON, CG SPIEGEL, AM AF SIMONDS, WF BUTRYNSKI, JE GAUTAM, N UNSON, CG SPIEGEL, AM TI G-PROTEIN BETA-GAMMA DIMERS - MEMBRANE TARGETING REQUIRES SUBUNIT COEXPRESSION AND INTACT GAMMA C-A-A-X DOMAIN SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Note ID ROD OUTER SEGMENTS; ALPHA-SUBUNITS; RAS PROTEINS; SIGNAL TRANSDUCTION; BINDING-PROTEINS; CYSTEINE RESIDUE; BOVINE BRAIN; EXPRESSION; GENES; SEPARATION AB Attachment of heterotrimeric G-proteins to the inner face of the plasma membrane is fundamental to their role as signal transducers by allowing interaction with both receptors and effectors. Certain G-protein alpha-subunits are anchored to the membrane by covalent myristoylation. The beta-gamma-complex is required for G-protein interaction with receptors and is independently membrane associated through an unknown mechanism. A series of carboxyl-terminal modifications including isoprenylation which may contribute to membrane attachment has been identified recently in G-protein gamma-subunits. Expression and membrane targeting of beta and gamma-subunits were examined in COS cells. The expression of either subunit was found to require cotransfection with both beta and gamma-cDNAs. Mutation of the carboxyl-terminal cysteine residue of gamma shown to undergo isoprenylation and carboxymethyl-esterification preserved beta-gamma-expression but blocked isoprenylation and membrane attachment. These results implicate the carboxyl-terminal processing of G-protein gamma-subunits and beta-coexpression as necessary and sufficient for membrane targeting of the beta-gamma-complex. C1 CALTECH,DIV BIOL,PASADENA,CA 91125. ROCKEFELLER UNIV,NEW YORK,NY 10021. RP SIMONDS, WF (reprint author), NIDDKD,MOLEC PATHOPHYSIOL BRANCH,BETHESDA,MD 20892, USA. FU NIGMS NIH HHS [GM34236, R37 GM034236] NR 48 TC 196 Z9 196 U1 0 U2 0 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD MAR 25 PY 1991 VL 266 IS 9 BP 5363 EP 5366 PG 4 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA FD370 UT WOS:A1991FD37000003 PM 1706334 ER PT J AU DHARIWAL, KR SHIRVAN, M LEVINE, M AF DHARIWAL, KR SHIRVAN, M LEVINE, M TI ASCORBIC-ACID REGENERATION IN CHROMAFFIN GRANULES - INSITU KINETICS SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID BOVINE ADRENAL-MEDULLA; CELL-VOLUME REGULATION; NOREPINEPHRINE BIOSYNTHESIS; ELECTRON-TRANSFER; MYCOPLASMA-GALLISEPTICUM; MEMBRANE; TRANSPORT; ENZYMES; ATP; PH AB We have investigated in intact chromaffin secretory vesicles the kinetics, specificity, and mechanism of intragranular ascorbic acid regeneration by extragranular ascorbic acid. The apparent K(m) of internal ascorbic acid regeneration for external ascorbic acid was 280-mu-M by Lineweaver-Burk analysis and 287-mu-M by Eadie-Hofstee analysis. Intragranular ascorbic acid regeneration was specifically mediated by extragranular ascorbic acid or its isomer isoascorbic acid; the reducing agents glutathione, thiourea, homocysteine, NADH, and NADPH did not support regeneration. The structural analog D-glucose did not inhibit regeneration by external ascorbic acid, suggesting specificity at the membrane site of electron transfer. The driving force for regeneration of intragranular ascorbic acid was independent of membrane potential, absolute intragranular and extragranular pH, and ATPase activity, but might be coupled to the pH difference across the chromaffin granule membrane. Since the apparent K(m) of regeneration was approximately 10-fold below the cytosolic concentration of ascorbic acid, the reaction may proceed at V(max) in situ. C1 NIDDKD,CELL BIOL & KINET LAB,BLDG 8,ROOM 419,BETHESDA,MD 20892. NR 30 TC 24 Z9 25 U1 0 U2 1 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD MAR 25 PY 1991 VL 266 IS 9 BP 5384 EP 5387 PG 4 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA FD370 UT WOS:A1991FD37000007 PM 1825997 ER PT J AU CHOU, JY RUPPERT, S SHELLY, LL PAN, CJ AF CHOU, JY RUPPERT, S SHELLY, LL PAN, CJ TI ISOLATION AND CHARACTERIZATION OF MOUSE HEPATOCYTE LINES CARRYING A LETHAL ALBINO DELETION SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID LIVER DIFFERENTIATION INVITRO; PHOSPHOENOLPYRUVATE CARBOXYKINASE; MESSENGER-RNA; GENE; CHROMOSOME-7; LOCUS; METALLOTHIONEIN; ESTABLISHMENT; TYROSINASE; EXPRESSION AB Mice homozygous for chromosomal deletions at or around the albino locus on chromosome 7 express reduced levels of a group of liver genes, including tyrosine aminotransferase (TAT) and phosphoenolpyruvate carboxykinase (PEPCK), and generally die perinatally. Sequences within the deleted region are thought to encode a regulatory factor(s) that affects expression of these genes in trans. To facilitate study of the putative factors, we immortalized hepatocytes derived from newborn c(ch) wild-type and c14CoS deletion homozygous mice as well as c(ch)/c14CoS heterozygous mice using a SV40 temperature-sensitive A255 mutant virus. Three c14CoS deletion homozygous hepatocyte lines were characterized and compared with the homozygous wild-type and heterozygous lines. The SV40 tsA255 mutant-transformed hepatocyte lines were temperature-sensitive for maintenance of transformation and expressed many liver-specific genes. In agreement with in vivo studies, hepatocyte lines derived from mice homozygous for the deletion expressed reduced mRNA levels of a number of liver genes including TAT, PEPCK, X1, X2, and X7 in comparison with heterozygous and wild-type cell lines. Similar mRNA levels of transferrin and albumin, genes whose expression is unaffected by the mutation in vivo, were observed in all cell lines. The expression of two genes, X5 and metallothionein, reported to be reduced in newborn mutant mice, did not differ appreciably among cell lines. TAT and PEPCK have been shown to respond poorly to glucocorticoids and cAMP in newborn mutant mice. Interestingly, all affected liver genes tested were responsive to glucocorticoids and dibutyryl cAMP in deletion homozygous cell lines as well as in wild-type and heterozygote-derived cell lines. This may suggest that effects of the deletion on expression of liver-specific genes do not cause loss of responsiveness to glucocorticoids and cAMP. These immortalized hepatocyte lines, which express most, if not all, liver-specific genes, should provide a useful means for further investigation of the effects of the albino lethal deletion. C1 GERMAN CANC RES CTR,INST CELL & TUMOR BIOL,W-6900 HEIDELBERG,GERMANY. RP CHOU, JY (reprint author), NICHHD,HUMAN GENET BRANCH,BLDG 10,RM 9S242,BETHESDA,MD 20892, USA. NR 28 TC 13 Z9 13 U1 1 U2 1 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD MAR 25 PY 1991 VL 266 IS 9 BP 5716 EP 5722 PG 7 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA FD370 UT WOS:A1991FD37000056 PM 1848557 ER PT J AU XIAO, H KALMAN, M IKEHARA, K ZEMEL, S GLASER, G CASHEL, M AF XIAO, H KALMAN, M IKEHARA, K ZEMEL, S GLASER, G CASHEL, M TI RESIDUAL GUANOSINE 3',5'-BISPYROPHOSPHATE SYNTHETIC ACTIVITY OF RELA NULL MUTANTS CAN BE ELIMINATED BY SPOT NULL MUTATIONS SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID COLI RNA-POLYMERASE; ESCHERICHIA-COLI; 5'-DIPHOSPHATE 3'-DIPHOSPHATE; GENE-PRODUCT; HISTIDINE OPERON; SALMONELLA-TYPHIMURIUM; STRINGENT RESPONSE; PROTEIN-SYNTHESIS; PPGPP; TETRAPHOSPHATE AB It was known previously that 1) the relA gene of Escherichia coli encodes an enzyme capable of guanosine 3',5'-bispyrophosphate (ppGpp) synthesis, 2) an uncharacterized source of ppGpp synthesis exists in relA null strains, and 3) cellular degradation of ppGpp is mainly due to a manganese-dependent ppGpp 3'-pyrophosphohydrolase encoded by the spoT gene. Here, the effects of spoT gene insertions and deletions are compared with analogous alterations in neighboring genes in the spo operon and found to be lethal in relA+ strains as well as slower growing in relAl backgrounds than DELTA-relA hosts. Cells with null alleles in both the relA and spoT genes are found no longer to accumulate ppGpp after glucose exhaustion or after chelation of manganese ions by picolinic acid addition; the inability to form ppGpp is reversed by a minimal spoT gene on a multicopy plasmid. Strains apparently lacking ppGpp show a complex phenotype including auxotrophy for several amino acids and morphological alterations. We propose that the SpoT protein can either catalyze or control the alternative pathway of ppGpp synthesis in addition to its known role as a (p)ppGpp 3'-pyrophosphohydrolase. We favor the possibility that the SpoT protein is a bifunctional enzyme capable of catalyzing either ppGpp synthesis or degradation. C1 NICHHD,MOLEC REGULAT SECT,MOLEC GENET LAB,BLDG 6,RM 333,BETHESDA,MD 20892. FU PHS HHS [25286] NR 61 TC 475 Z9 481 U1 2 U2 12 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD MAR 25 PY 1991 VL 266 IS 9 BP 5980 EP 5990 PG 11 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA FD370 UT WOS:A1991FD37000096 PM 2005134 ER PT J AU KASPRZAK, KS WARD, JM AF KASPRZAK, KS WARD, JM TI PREVENTION OF NICKEL SUBSULFIDE CARCINOGENESIS BY LOCAL-ADMINISTRATION OF MYCOBACTERIUM-BOVIS ANTIGEN IN MALE F344 NCR RATS SO TOXICOLOGY LA English DT Article DE NICKEL CARCINOGENESIS; MYCOBACTERIUM-BOVIS ID SUPPRESSION; MANGANESE AB This study was designed to determine the effect of local inflammation on nickel subsulfide (Ni3S2) carcinogenesis. Male F344/NCr rats, 6-week-old, 20 rats/group, received a single i.m. injection of 2.5 mg of Ni3S2 alone or 2.5 mg of Ni3S2 mixed with either 0.5 mg of Mycobacterium bovis lyophilized cell walls (MB), 1 mg cortisol (CORT), or 1 mg indomethacin (IND). Two more groups of rats received i.m. Ni3S2 alone, as above, followed by a single s.c. dose of either 1 mg MB or 2 mg IND. The i.m. injections were made into the thigh muscles of both hind limbs; the s.c. injections were made at the neck area. The experiment was terminated at 71 weeks. The final yields of injection site sarcomas were 85% in the Ni3S2, 85% in the Ni3S2 + CORT, and 80% in the Ni3S2 + IND group. Only one injection site tumor (5%) was found in rats given i.m. Ni3S2 + MB. in contrast, the s.c. MB injection enhanced muscular carcinogenicity of Ni3S2 by shortening the latency and increasing the yield of tumors to 100% at week 39 (P < 0.04 vs. Ni3S2 alone). The s.c. treatment with IND gave similar, though statistically nonsignificant results; 100% tumor yield was reached at week 42 (P < 0.18 vs. Ni3S2 alone). Although local treatment with CORT or IND had no significant effect on the final tumor incidence by Ni3S2, it shortened the latency of tumors to 17 weeks compared with 23 weeks for Ni3S2 alone. MB, CORT, IND, or the injection vehicle (water) alone did not produce tumors. Local MB treatment had no significant effect on the retention of Ni3S2 at the injection site. The prevention of the Ni3S2 tumors by local MB might result from localization of numerous natural killer cells and macrophages and formation of giant cells observed at the injection site of Ni3S2, 1-14 days post injection. These cells could immobilize the carcinogen and destroy Ni3S2-transformed cells. RP KASPRZAK, KS (reprint author), NCI,FCRDC,DIV CANC ETIOL,COMPARAT CARCINOGENESIS LAB,BLDG 538,ROOM 205,FREDERICK,MD 21702, USA. NR 17 TC 4 Z9 4 U1 0 U2 1 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0300-483X J9 TOXICOLOGY JI Toxicology PD MAR 25 PY 1991 VL 67 IS 1 BP 97 EP 105 DI 10.1016/0300-483X(91)90167-Y PG 9 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA FJ196 UT WOS:A1991FJ19600009 PM 2017766 ER PT J AU FREO, U LARSON, DM TOLLIVER, T RAPOPORT, SI SONCRANT, TT AF FREO, U LARSON, DM TOLLIVER, T RAPOPORT, SI SONCRANT, TT TI PARACHLOROAMPHETAMINE SELECTIVELY ALTERS REGIONAL CEREBRAL METABOLIC RESPONSES TO THE SEROTONERGIC AGONIST METACHLOROPHENYLPIPERAZINE IN RATS SO BRAIN RESEARCH LA English DT Article DE DEOXYGLUCOSE; SEROTONIN; PARACHLOROAMPHETAMINE; METACHLOROPHENYLPIPERAZINE; QUIPAZINE; BROMOCRIPTINE; ARECOLINE ID PARA-CHLOROAMPHETAMINE; GLUCOSE-UTILIZATION; BEHAVIORAL SYNDROME; LOCOMOTOR-ACTIVITY; RECOGNITION SITES; 5-HT1B RECEPTORS; FRONTAL-CORTEX; CONSCIOUS RAT; BINDING-SITES; BRAIN AB To determine if reported reductions of regional cerebral metabolic rates for glucose (rCMRglc) induced by the 5-HT agent metachlorophenylpiperazine (MCPP) (2.5 mg/kg) are due to a presynaptic action, 3-month old Fischer-344 rats were given parachloroamphetamine (PCA), a serotonin neurotoxin, and rCMRglc was measured 1 or 3 weeks later with the quantitative autoradiographic [C-14]2-deoxyglucose procedure in 74 brain regions after administering saline, MCPP or other drugs. PCA alone increased rCMRglc significantly only in the raphe nuclei and in visual structures (visual cortex, lateral geniculate, superior colliclus). MCPP alone reduced rCMRglc in 75% of the regions studied. In PCA-lesioned rats, metabolic responses to MCPP 2.5 mg/kg were virtually abolished and rCMRglc was increased in interanteromedial and centrolateral thalamic nuclei. rCMRglc responses to quipazine, a postsynaptic serotonin agonist, and to arecoline and bromocriptine, cholinergic and dopaminergic agonists, were unchanged by PCA-pretreatment. Selective abolition by PCA of the metabolic response to MCPP confirms that MCPP, at the dose studied, reduces rCMRglc in the forebrain via a presynaptic mechanism and that postsynaptic serotonergic function is not altered by PCA. RP SONCRANT, TT (reprint author), NIA,NEUROSCI LAB,BETHESDA,MD 20892, USA. NR 72 TC 15 Z9 15 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0006-8993 J9 BRAIN RES JI Brain Res. PD MAR 22 PY 1991 VL 544 IS 1 BP 17 EP 25 DI 10.1016/0006-8993(91)90880-5 PG 9 WC Neurosciences SC Neurosciences & Neurology GA FF019 UT WOS:A1991FF01900002 PM 1713115 ER PT J AU SMITH, MA BRADY, LS GLOWA, J GOLD, PW HERKENHAM, M AF SMITH, MA BRADY, LS GLOWA, J GOLD, PW HERKENHAM, M TI EFFECTS OF STRESS AND ADRENALECTOMY ON TYROSINE-HYDROXYLASE MESSENGER-RNA LEVELS IN THE LOCUS-CERULEUS BY INSITU HYBRIDIZATION SO BRAIN RESEARCH LA English DT Article DE TYROSINE HYDROXYLASE; LOCUS CERULEUS; INSITU HYBRIDIZATION; MESSENGER RIBONUCLEIC ACID; FOOTSHOCK STRESS; RESTRAINT STRESS; ADRENALECTOMY ID RAT-BRAIN; NORADRENALINE TURNOVER; CHRONIC FOOTSHOCK; NOREPINEPHRINE; EXPOSURE; COLD; DEPLETION; PITUITARY; DOPAMINE; SYSTEM AB The locus ceruleus-norepinephrine system is one of the principal effectors of the stress response. Acute stress induces norepinephrine synthesis and release, and noradrenergic cells compensate by increasing the activity of tyrosine hydroxylase, the rate-limiting enzyme in catecholamine synthesis. Here we use in situ hybridization histochemistry to show the effects of acute and chronic intermittent stress on the expression of tyrosine hydroxylase mRNA in the rat locus cereleus. Restraint stress increased tyrosine hydroxylase mRNA in the locus ceruleus but not in dopaminergic nuclei such as the substantia nigra or ventral tegmental area. One hour of footshock or restraint caused a rapid increase in locus ceruleus tyrosine hydroxylase mRNA which returned to basal levels within 24 h. Chronic intermittent stress (1 hour of restraint or footshock per day for 14 days) produced no change in tyrosine hydroxylase mRNA. Neither adrenalectomy nor dexamethasone replacement significantly affected mRNA expression. These findings indicate that acute stress can increase the expression of tyrosine hydroxylase mRNA in the locus ceruleus but that adaptation occurs to repeated stress, and that the expression of tyrosine hydroxylase mRNA in the locus ceruleus is independent of direct glucocorticoid modulation. C1 NIMH, FUNCT NEUROANAT SECT, BLDG 36, RM 2D15, BETHESDA, MD 20892 USA. NR 36 TC 108 Z9 108 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0006-8993 EI 1872-6240 J9 BRAIN RES JI Brain Res. PD MAR 22 PY 1991 VL 544 IS 1 BP 26 EP 32 DI 10.1016/0006-8993(91)90881-U PG 7 WC Neurosciences SC Neurosciences & Neurology GA FF019 UT WOS:A1991FF01900003 PM 1677301 ER PT J AU MERCHENTHALER, I AF MERCHENTHALER, I TI COLOCALIZATION OF ENKEPHALIN AND TRH IN PERIFORNICAL NEURONS OF THE RAT HYPOTHALAMUS THAT PROJECT TO THE LATERAL SEPTUM SO BRAIN RESEARCH LA English DT Note DE RETROGRADE TRACER; DOUBLE LABELING; IMMUNOCYTOCHEMISTRY; NEUROPEPTIDE; NEUROANATOMY; OPIOID; TELENCEPHALON ID THYROTROPIN-RELEASING-HORMONE; CENTRAL NERVOUS-SYSTEM; IMMUNOCYTOCHEMICAL LOCALIZATION; METHIONINE-ENKEPHALIN; IDENTIFICATION; AFFERENTS; PEPTIDES; ORIGIN; GOLD AB Neurons of the lateral septal nucleus are surrounded by terminals immunoreactive for thyrotropin-releasing hormone (TRH) and enkephalin (Enk). Retrograde labeling from the lateral septum in combination with immunocytochemical analyses for Enk and TRH in colchicine-treated rats has revealed that nearly all Enk- (and TRH-) containing perifornical neurons project to the lateral septum. Immunostaining of adjacent, thin paraffin sections for either TRH or Enk and double staining of thick vibratome sections for the two peptides have shown that TRH and Enk immunoreactivities co-exist within the same neurons in the perifornical region of the hypothalamus. RP MERCHENTHALER, I (reprint author), NIEHS,FUNCT MORPHOL SECT,MOLEC & INTEGRAT NEUROSCI LAB,MD C4-07,RES TRIANGLE PK,NC 27709, USA. NR 24 TC 16 Z9 16 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0006-8993 J9 BRAIN RES JI Brain Res. PD MAR 22 PY 1991 VL 544 IS 1 BP 177 EP 180 DI 10.1016/0006-8993(91)90903-9 PG 4 WC Neurosciences SC Neurosciences & Neurology GA FF019 UT WOS:A1991FF01900025 PM 1713116 ER PT J AU ROSNER, MH DESANTO, RJ ARNHEITER, H STAUDT, LM AF ROSNER, MH DESANTO, RJ ARNHEITER, H STAUDT, LM TI OCT-3 IS A MATERNAL FACTOR REQUIRED FOR THE 1ST MOUSE EMBRYONIC DIVISION SO CELL LA English DT Article ID DNA-REPLICATION; BINDING-PROTEINS; EMBRYOGENESIS; SEQUENCE; CELLS; TRANSCRIPTION AB Oct-3 is a POU domain transcription factor that binds the octamer DNA motif and is present in mouse oocytes before and after fertilization. When fertilized oocytes were injected with antisense Oct-3 oligonucleotides or double-stranded DNA containing the octamer motif, embryonic DNA synthesis was inhibited and the embryos were arrested at the one-cell stage. In vitro synthesized Oct-3 mRNA rescued the developmental block induced by antisense Oct-3 oligonucleotide. We conclude that maternally inherited Oct-3 is required for DNA replication and division of the one-cell embryo. C1 GEORGETOWN UNIV,SCH MED,DEPT PATHOL,WASHINGTON,DC 20057. RP ROSNER, MH (reprint author), NCI,METAB BRANCH,BETHESDA,MD 20892, USA. NR 26 TC 48 Z9 50 U1 0 U2 0 PU CELL PRESS PI CAMBRIDGE PA 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 SN 0092-8674 J9 CELL JI Cell PD MAR 22 PY 1991 VL 64 IS 6 BP 1103 EP 1110 DI 10.1016/0092-8674(91)90265-Z PG 8 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA FD558 UT WOS:A1991FD55800008 PM 2004418 ER PT J AU SHIVER, JW HENKART, PA AF SHIVER, JW HENKART, PA TI A NONCYTOTOXIC MAST-CELL TUMOR LINE EXHIBITS POTENT IGE-DEPENDENT CYTOTOXICITY AFTER TRANSFECTION WITH THE CYTOLYSIN PERFORIN GENE SO CELL LA English DT Article ID PURIFIED CYTOPLASMIC GRANULES; TOXIC LYMPHOCYTES-T; KILLER CELLS; LYSIS; INHIBITION; ANTIBODIES; EXPRESSION; INDUCTION; MECHANISM; SECRETION AB To test the granule exocytosis model for lymphocyte cytotoxicity, we have expressed the gene for the cytotoxic lymphocyte granule protein cytolysin (perforin) in the noncytotoxic rat basophilic leukemia (RBL) cell line, which undergoes granule exocytosis when its high affinity IgE receptor is cross-linked. Homogenates of RBL-cytolysin (RBL-cy) transfectants showed a calcium-dependent hemolytic activity in dense granule fractions, demonstrating that the expressed cytolysin protein was correctly targeted to secretory granules. RBL-cy transfectants showed a potent and calcium-dependent cytolytic activity against IgE-coated RBCs, while the parental RBL line was not cytotoxic under these conditions. RBL-cy cells did not lyse non-IgE-coated RBCs copelleted with targets: this sparing of "innocent bystanders" parallels cytotoxic T lymphocyte lysis and suggests a polarized secretion of cytolysin. In contrast to RBC targets, IgE-coated tumor cells were much less sensitive to lysis by RBL-cy transfectants. RP SHIVER, JW (reprint author), NCI,EXPTL IMMUNOL BRANCH,BLDG 10,ROOM 4B17,BETHESDA,MD 20892, USA. NR 31 TC 80 Z9 80 U1 0 U2 0 PU CELL PRESS PI CAMBRIDGE PA 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 SN 0092-8674 J9 CELL JI Cell PD MAR 22 PY 1991 VL 64 IS 6 BP 1175 EP 1181 DI 10.1016/0092-8674(91)90272-Z PG 7 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA FD558 UT WOS:A1991FD55800015 PM 2004423 ER PT J AU ORCI, L TAGAYA, M AMHERDT, M PERRELET, A DONALDSON, JG LIPPINCOTTSCHWARTZ, J KLAUSNER, RD ROTHMAN, JE AF ORCI, L TAGAYA, M AMHERDT, M PERRELET, A DONALDSON, JG LIPPINCOTTSCHWARTZ, J KLAUSNER, RD ROTHMAN, JE TI BREFELDIN-A, A DRUG THAT BLOCKS SECRETION, PREVENTS THE ASSEMBLY OF NON-CLATHRIN-COATED BUDS ON GOLGI CISTERNAE SO CELL LA English DT Article ID ENDOPLASMIC-RETICULUM; PROTEIN-TRANSPORT; VESICULAR TRANSPORT; INTRACELLULAR-TRANSPORT; RAT HEPATOCYTES; FUSION PROTEIN; STACK; YEAST; RECONSTITUTION; COMPLEX AB We report that brefeldin A prevents the assembly of non-clathrin-coated vesicles from Golgi cisternae in a cell-free system. This finding provides a simple molecular explanation for the primary effect of this remarkable compound in blocking constitutive secretion. We further report that when coated vesicle assembly is blocked, extensive tubule networks form that connect previously separate cisternae and stacks into a single topological unit, allowing the intermixing of contents of Golgi cisternae, presumably by lateral diffusion. Formation of the tubule networks requires ATP, cytosol, and the general fusion protein NSF. Tubule networks may be related to the membrane tubules mediating retrograde transport in vivo. C1 PRINCETON UNIV,DEPT MOLEC BIOL,LEWIS THOMAS LAB,PRINCETON,NJ 08544. NICHHD,CELL BIOL & METAB BRANCH,BETHESDA,MD 20892. RP ORCI, L (reprint author), UNIV GENEVA,SCH MED,INST HISTOL & EMBRYOL,1 RUE MICHEL SERVET,CH-1211 GENEVA 4,SWITZERLAND. FU NIDDK NIH HHS [DK 27044] NR 40 TC 413 Z9 416 U1 3 U2 8 PU CELL PRESS PI CAMBRIDGE PA 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 SN 0092-8674 J9 CELL JI Cell PD MAR 22 PY 1991 VL 64 IS 6 BP 1183 EP 1195 PG 13 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA FD558 UT WOS:A1991FD55800016 PM 2004424 ER PT J AU SEI, Y ARORA, PK AF SEI, Y ARORA, PK TI QUANTITATIVE-ANALYSIS OF CALCIUM (CA2+) MOBILIZATION AFTER STIMULATION WITH MITOGENS OR ANTI-CD3 ANTIBODIES - SIMULTANEOUS FLUO-3 AND IMMUNOFLUORESCENCE FLOW-CYTOMETRY SO JOURNAL OF IMMUNOLOGICAL METHODS LA English DT Article DE CALCIUM FLUX; FLOW CYTOMETRY; FLUO-3; MONOCLONAL ANTIBODY; MITOGEN ID T-CELLS; LYMPHOCYTES; DIFFERENTIATION; INDICATORS; INDO-1 AB A method is described for flow microfluorometric analysis of calcium mobilization in immune cells. This method is based on dual-color analysis of heterogeneous cell populations using fluo-3 and phycoerythrin (PE)-conjugated monoclonal antibody (mAb). This technique allows the detection of fluo-3 fluorescence as a measure of an increase in cytoplasmic free calcium ([Ca2+]i) while simultaneously discriminating PE-mAb-labeled cells without using wavelength ratio imaging. This method provides a unique way to distinguish patterns of calcium mobilization within a heterogeneous cell population. C1 NIDDK,NEUROSCI LAB,BLDG 8,ROOM 111,BETHESDA,MD 20892. NR 17 TC 44 Z9 45 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1759 J9 J IMMUNOL METHODS JI J. Immunol. Methods PD MAR 21 PY 1991 VL 137 IS 2 BP 237 EP 244 PG 8 WC Biochemical Research Methods; Immunology SC Biochemistry & Molecular Biology; Immunology GA FD419 UT WOS:A1991FD41900011 PM 1672879 ER PT J AU PAVLIAK, V KOVAC, P AF PAVLIAK, V KOVAC, P TI SYNTHESIS OF LIGANDS RELATED TO THE O-SPECIFIC ANTIGEN OF SHIGELLA-DYSENTERIAE TYPE .1. A SHORT SYNTHESIS OF 1,3,4,6-TETRA-O-ACETYL-2-AZIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE AND THE CORRESPONDING ALPHA-GLUCOSYL CHLORIDE FROM D-MANNOSE SO CARBOHYDRATE RESEARCH LA English DT Note ID OLIGOSACCHARIDES; METHYL; TRIFLUORIDE C1 NIDDK,BETHESDA,MD 20892. NR 16 TC 46 Z9 48 U1 2 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0008-6215 J9 CARBOHYD RES JI Carbohydr. Res. PD MAR 20 PY 1991 VL 210 BP 333 EP 337 DI 10.1016/0008-6215(91)80134-9 PG 5 WC Biochemistry & Molecular Biology; Chemistry, Applied; Chemistry, Organic SC Biochemistry & Molecular Biology; Chemistry GA FJ294 UT WOS:A1991FJ29400027 PM 1878884 ER PT J AU JABLON, S HRUBEC, Z BOICE, JD AF JABLON, S HRUBEC, Z BOICE, JD TI CANCER IN POPULATIONS LIVING NEAR NUCLEAR-FACILITIES - A SURVEY OF MORTALITY NATIONWIDE AND INCIDENCE IN 2 STATES SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID CHILDHOOD LEUKEMIA; POWER PLANT; INSTALLATIONS; PATTERNS; VICINITY; SITES AB Reports from the United Kingdom have described increases in leukemia and lymphoma among young persons living near certain nuclear installations. Because of concerns raised by these reports, a mortality survey was conducted in populations living near nuclear facilities in the United States. All facilities began service before 1982. Over 900 000 cancer deaths occurred from 1950 through 1984 in 107 counties with or near nuclear installations. Each study county was matched for comparison to three "control counties" in the same region. There were 1.8 million cancer deaths in the 292 control counties during the 35 years studied. Deaths due to leukemia or other cancers were not more frequent in the study counties than in the control counties. For childhood leukemia mortality, the relative risk comparing the study counties with their controls before plant start-up was 1.08, while after start-up it was 1.03. For leukemia mortality at all ages, the relative risks were 1.02 before start-up and 0.98 after. For counties in two states, cancer incidence data were also available. For one facility, the standardized registration ratio for childhood leukemia was increased significantly after start-up. However, the increase also antedated the operation of this facility. The study is limited by the correlational approach and the large size of the geographic areas (counties) used. It does not prove the absence of any effect. If, however, any excess cancer risk was present in US counties with nuclear facilities, it was too small to be detected with the methods employed. RP JABLON, S (reprint author), NCI,RADIAT EPIDEMIOL BRANCH,EPIDEMIOL & BIOSTAT PROGRAM,BETHESDA,MD 20892, USA. NR 30 TC 51 Z9 51 U1 1 U2 5 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD MAR 20 PY 1991 VL 265 IS 11 BP 1403 EP 1408 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA FB550 UT WOS:A1991FB55000020 PM 1999880 ER PT J AU HALL, WH AF HALL, WH TI NIH TECHNOLOGY-ASSESSMENT CONFERENCE STATEMENT ON BOVINE SOMATOTROPIN SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article RP HALL, WH (reprint author), NIH,OFF MED APPLICAT RES,BLDG 1,ROOM 260,BETHESDA,MD 20892, USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD MAR 20 PY 1991 VL 265 IS 11 BP 1423 EP 1425 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA FB550 UT WOS:A1991FB55000024 ER PT J AU HANKEY, BF EDWARDS, BK RIES, LA PERCY, CL SHAMBAUGH, E AF HANKEY, BF EDWARDS, BK RIES, LA PERCY, CL SHAMBAUGH, E TI PROBLEMS IN CANCER SURVEILLANCE - DELINEATING INSITU AND INVASIVE BLADDER-CANCER SO JOURNAL OF THE NATIONAL CANCER INSTITUTE LA English DT Editorial Material C1 NCI,SURVEILLANCE PROGRAM,EXECUT PLAZA N,RM 343J,BETHESDA,MD 20892. NCI,CANC STAT BRANCH,BETHESDA,MD 20892. NR 4 TC 17 Z9 17 U1 0 U2 0 PU NATL CANCER INSTITUTE PI BETHESDA PA 9030 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0027-8874 J9 J NATL CANCER I JI J. Natl. Cancer Inst. PD MAR 20 PY 1991 VL 83 IS 6 BP 384 EP 385 DI 10.1093/jnci/83.6.384 PG 2 WC Oncology SC Oncology GA FB835 UT WOS:A1991FB83500002 PM 1999842 ER PT J AU NADLER, SG MERRILL, BM ROBERTS, WJ KEATING, KM LISBIN, MJ BARNETT, SF WILSON, SH WILLIAMS, KR AF NADLER, SG MERRILL, BM ROBERTS, WJ KEATING, KM LISBIN, MJ BARNETT, SF WILSON, SH WILLIAMS, KR TI INTERACTIONS OF THE A1 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN AND ITS PROTEOLYTIC DERIVATIVE, UP1, WITH RNA AND DNA - EVIDENCE FOR MULTIPLE RNA-BINDING DOMAINS AND SALT-DEPENDENT BINDING MODE TRANSITIONS SO BIOCHEMISTRY LA English DT Article ID HELIX-DESTABILIZING PROTEIN; ESCHERICHIA-COLI; CALF THYMUS; COOPERATIVE BINDING; DROSOPHILA ENCODES; GENE-32 PROTEIN; COMPLEXES; ACIDS; SPECIFICITY; PARTICLES AB The 319-residue A1 heterogeneous nuclear ribonucleoprotein is the best studied of the group of major or core mammalian hnRNP proteins that bind pre-mRNA immediately following transcription. Circular dichroism studies suggest that binding of A1 and its proteolytic fragment, UP1 (residues 1-195), to nucleic acids results in an unstacking of the bases of poly(A). On the basis of poly[d(A-T)] and poly[r(A-U)] melting studies, both A1 and UP1 are helix-destabilizing proteins. Titrations of A1 and UP1 with poly(A), poly(U), and poly[d(T)] suggest that these two proteins do not bind with significant base specificity. A previous study indicated that A1, which contains a glycine-rich COOH terminus (residues 196-319) not present in UP1, binds cooperatively to polynucleotides while UP1 does not [Cobianchi et al. (1988) J. Biol. Chem. 263, 1063-1071]. Here we confirm this latter finding and demonstrate that the cooperativity parameter for A1 binding, which has a value of about 35 for binding to both single-stranded RNA and DNA, is insensitive to the NaCl concentration at least up to 0.4 M. In contrast to the cooperativity parameter, the occluded site size for A1 binding to RNA is salt dependent and increases from about 14 to 28 upon increasing the NaCl concentration from 25 to 250 mM. This variation in site size is best explained by assuming that A1 can interact with nucleic acids via at least two different binding modes. Both A1 and UP1 have higher affinity for single-stranded as opposed to double-stranded nucleic acids and bind preferentially to single-stranded RNA as compared to DNA. Comparative studies on the binding of A1 versus UP1 to poly[r(epsilon-A)] demonstrate that in addition to cooperative protein/protein interactions, the glycine-rich COOH-terminal domain of A1 is also directly involved in protein/nucleic acid interactions. These conclusions are directly confirmed by studies on a 48-residue synthetic peptide corresponding to residues 260-307 in A1. In 10 mM NaCl, this peptide has an intrinsic affinity of 1.5 X 10(6) M-1 for poly[r(epsilon-A)] and a cooperativity parameter of about 30. The similar cooperativity parameters for A1 and this synthetic peptide analogue suggests that most of the structural determinants necessary for A1/A1 cooperative protein interactions are within residues 260-307 in A1. Together these studies demonstrate that the UP1 and glycine-rich COOH-terminal domains of A1 make an approximately equal and independent contribution to the overall free energy of A1 binding to single-stranded RNA. C1 YALE UNIV,DEPT MOLEC BIOPHYS & BIOCHEM,NEW HAVEN,CT 06510. HOWARD HUGHES MED INST,NEW HAVEN,CT 06510. NCI,BIOCHEM LAB,BETHESDA,MD 20892. FU NIGMS NIH HHS [GM31539] NR 37 TC 78 Z9 78 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0006-2960 J9 BIOCHEMISTRY-US JI Biochemistry PD MAR 19 PY 1991 VL 30 IS 11 BP 2968 EP 2976 DI 10.1021/bi00225a034 PG 9 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA FC455 UT WOS:A1991FC45500034 PM 1848781 ER PT J AU WEISSMAN, AD DESOUZA, EB AF WEISSMAN, AD DESOUZA, EB TI CHRONIC TREATMENT OF RATS WITH THE SPECIFIC SIGMA-LIGAND D-PENTAZOCINE FAILS TO MODULATE DOPAMINE D2 AND SIGMA-BINDING IN BRAIN SO EUROPEAN JOURNAL OF PHARMACOLOGY LA English DT Note DE SIGMA-RECEPTORS; PHENCYCLIDINE; PSYCHOSIS; DOPAMINE; HALOPERIDOL; YM-09151-2 ID GUINEA-PIG; RECEPTOR; SITES; AGONIST AB Drugs that bind at the sigma site have been proposed to have psychotomimetic and/or antipsychotic activity that is independent from that mediated by the phencyclidine (PCP) receptor. Some evidence suggests that sigma ligands may produce their effects by modulation of dopamine neurotransmission. The present study examined potential interactions between the sigma and dopamine system following chronic treatment with d-pentazocine, a specific sigma-ligand that has negligible affinity for either PCP or dopamine receptors. Rats treated for one month with either saline or 10 mg/kg per day d-pentazocine revealed no significant differences in either the K(D) or B(max) of [H-3]haloperidol-labeled-sigma or [H-3]YM-09151-2-labeled dopamine D2 receptors across multiple brain regions. These results are discussed in relation to the pharmacology of putative sigma-receptor subtypes. RP WEISSMAN, AD (reprint author), NIDA,ADDICT RES CTR,NEUROSCI BRANCH,POB 5180,BALTIMORE,MD 21224, USA. NR 11 TC 9 Z9 9 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0014-2999 J9 EUR J PHARMACOL JI Eur. J. Pharmacol. PD MAR 19 PY 1991 VL 195 IS 1 BP 163 EP 165 DI 10.1016/0014-2999(91)90395-7 PG 3 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA FF170 UT WOS:A1991FF17000021 PM 1648492 ER PT J AU ABE, R KANAGAWA, O SHEARD, MA FOOPHILLIPS, M AF ABE, R KANAGAWA, O SHEARD, MA FOOPHILLIPS, M TI CLUSTER OF SELF ANTIGENS RECOGNIZED BY I-E REACTIVE TCR V-BETA-S, V-BETA-5, V-BETA-11 AND V-BETA-12 SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,BETHESDA,MD 20892. WASHINGTON UNIV,SCH MED,ST LOUIS,MO 63110. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1778 EP A1778 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701869 ER PT J AU AKUNNE, HC DECOSTA, BR JACOBSON, AE RICE, KC ROTHMAN, RB AF AKUNNE, HC DECOSTA, BR JACOBSON, AE RICE, KC ROTHMAN, RB TI PAROXETINE ALLOSTERICALLY MODULATES A [H-3] COCAINE BINDING-SITE ASSOCIATED WITH THE SEROTONIN TRANSPORTER IN GUINEA-PIG BRAIN SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIDDKD,MED CHEM LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1590 EP A1590 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700775 ER PT J AU ALBER, G MILLER, L VARINBLANK, N METZGER, H AF ALBER, G MILLER, L VARINBLANK, N METZGER, H TI STRUCTURE/FUNCTION RELATIONSHIPS IN THE MAST-CELL HIGH-AFFINITY RECEPTOR FOR IGE(FC-EPSILON-RI) - ROLE OF CYTOPLASMIC DOMAINS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAMSD,BETHESDA,MD 20892. NR 1 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1675 EP A1675 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701268 ER PT J AU BAROUCH, W GREENE, L EISENBERG, E AF BAROUCH, W GREENE, L EISENBERG, E TI AN INITIAL BURST OF ATP HYDROLYSIS ACCOMPANIES THE UNCOATING OF CLATHRIN-COATED VESICLES BY UNCOATING ATPASE SO FASEB JOURNAL LA English DT Meeting Abstract C1 NHLBI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1559 EP A1559 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700590 ER PT J AU BEAVEN, MA HIDE, M ALI, H PRICE, SR MOSS, J AF BEAVEN, MA HIDE, M ALI, H PRICE, SR MOSS, J TI THE GTP-BINDING PROTEIN, G-ALPHA-Z - ITS DOWN REGULATION BY DEXAMETHASONE AND ITS CREDENTIALS AS A MEDIATOR OF ANTIGEN-INDUCED RESPONSES IN RBL-2H3 CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NHLBI,BETHESDA,MD 20892. NR 2 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1676 EP A1676 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701271 ER PT J AU BERLETT, BS OMAR, OHM SAHAKIAN, JA LEVINE, RL STADTMAN, ER AF BERLETT, BS OMAR, OHM SAHAKIAN, JA LEVINE, RL STADTMAN, ER TI OXIDATION OF PROTEINS BY OZONE SO FASEB JOURNAL LA English DT Meeting Abstract C1 NHLBI,BIOCHEM LAB,BETHESDA,MD 20892. RI Levine, Rodney/D-9885-2011 NR 0 TC 6 Z9 6 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1524 EP A1524 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700386 ER PT J AU BLANCHARD, DK PEARSON, CA SERBOUSEK, D MATSUSHIMA, K OPPENHEIM, JJ DJEU, JY AF BLANCHARD, DK PEARSON, CA SERBOUSEK, D MATSUSHIMA, K OPPENHEIM, JJ DJEU, JY TI LARGE ANTIGRANULOCYTES LYMPHOCYTES PRODUCE INTERLEUKIN-8 IN RESPONSE TO OPPORTUNISTIC PATHOGENS SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV S FLORIDA,COLL MED,TAMPA,FL 33612. NCI,BIOL RESP MODIF PROGRAM,FREDERICK,MD 21701. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1770 EP A1770 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701824 ER PT J AU BOYD, LF MARGULIES, DH AF BOYD, LF MARGULIES, DH TI SOLUTION BINDING OF A CLASS-I MHC MOLECULE TO AN ANTIGENIC PEPTIDE SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAID,LI,BETHESDA,MD 20892. RI Margulies, David/H-7089-2013 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1677 EP A1677 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701282 ER PT J AU BRISTOL, LA ROMM, EV TAKACS, L AF BRISTOL, LA ROMM, EV TAKACS, L TI CHARACTERIZATION OF CD13 ANTIGEN (NEUTRAL AMINOPEPTIDASE) IN THE RAT - STIMULATION OF PMA AND IL-2-INDUCED PROLIFERATION OF CD4-THYMOCYTES CD8-THYMOCYTES VIA CD13 SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAAA,LPPS,ROCKVILLE,MD 20852. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1700 EP A1700 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701416 ER PT J AU BRUGH, SA DAVE, JR BERNTON, E RHODES, CS BURBELO, PD YAMADA, Y CHIANG, PK AF BRUGH, SA DAVE, JR BERNTON, E RHODES, CS BURBELO, PD YAMADA, Y CHIANG, PK TI MOLECULAR MIMICRY OF THE ACTION OF INSULIN IN PROMOTING CELLULAR OBESITY IN 3T3-L1 FIBROBLASTS BY AN INDIRECT INHIBITOR OF METHYLATION, 3-DEAZAADENOSINE SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NIDR,BETHESDA,MD 20892. NR 1 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1664 EP A1664 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701210 ER PT J AU CASAZZA, JP VEECH, RL AF CASAZZA, JP VEECH, RL TI THE PRODUCTION OF 2,3-BUTANEDIOL IN MEAL FED ANIMALS INJECTED WITH SHORT CHAIN MONOCARBOXYLIC ACIDS SO FASEB JOURNAL LA English DT Meeting Abstract ID URINARY-EXCRETION C1 NIAAA,METAB & METAB CONTROL LAB,ROCKVILLE,MD 20852. NR 3 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1548 EP A1548 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700526 ER PT J AU CHIANG, PK BRUGH, SA GORDON, RK ESTRADA, JS BURBELO, PD YAMADA, Y AF CHIANG, PK BRUGH, SA GORDON, RK ESTRADA, JS BURBELO, PD YAMADA, Y TI SPECIFIC ACTIVATION OF THE COLLAGEN-IV PROMOTER-ENHANCER IN F9 TERATOCARCINOMA CELLS BY 3-DEAZAADENOSINE ANALOGS SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NIDR,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1650 EP A1650 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701128 ER PT J AU CHUANG, DM AF CHUANG, DM TI MODULATION BY ADENOSINE OF HISTAMINE-INDUCED PHOSPHOINOSITIDE TURNOVER IN NEUROHYBRID NCB-20 CELLS AND CULTURED CEREBELLAR NEURONS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIMH,BIOL PSYCHIAT BRANCH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1769 EP A1769 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701817 ER PT J AU CORR, M RIBAUDO, R MARGULIES, DH AF CORR, M RIBAUDO, R MARGULIES, DH TI EXPRESSION AND ASSEMBLY OF MEMBRANE AND SOLUBLE FORMS OF H-2DD IN SPODOPTERA-FRUGIPERDA CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAID,LI,BETHESDA,MD 20892. RI Margulies, David/H-7089-2013 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1685 EP A1685 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701324 ER PT J AU CULVER, KW CHIANG, Y ANDERSON, WF BLAESE, RM AF CULVER, KW CHIANG, Y ANDERSON, WF BLAESE, RM TI RETROVIRAL-MEDIATED TRANSDUCTION OF GENES ENCODING PRODUCTION OF HIL-1-BETA OR HTNF-ALPHA INTO MURINE CD8 T-CELLS DERIVED FROM TUMORS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NHLBI,BETHESDA,MD 20892. NCI,BETHESDA,MD 20892. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1712 EP A1712 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701486 ER PT J AU DAI, Y AMBUDKAR, IS BAUM, BJ AF DAI, Y AMBUDKAR, IS BAUM, BJ TI M3-MUSCARINIC-RECEPTORS IN RAT PAROTID-GLANDS APPEAR COUPLED TO BOTH CA2+ MOBILIZATION AND ADENYLYL CYCLASE INHIBITION SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIDR,CIPCB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1596 EP A1596 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700812 ER PT J AU DEGUCHI, Y FAUCI, AS KEHRL, JH AF DEGUCHI, Y FAUCI, AS KEHRL, JH TI CLONING AND EXPRESSION OF 2 NOVEL HOMEOTIC GENES IN HUMAN LYMPHOID-CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAID,IMMUNOREGULAT LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1696 EP A1696 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701390 ER PT J AU DURUM, SK LONGO, DL MURPHY, WJ AF DURUM, SK LONGO, DL MURPHY, WJ TI CD4/CD8 DIFFERENTIATION OF T-CELLS IN MICE WITH SEVERE COMBINED IMMUNODEFICIENCY (SCID) WITHOUT RECEPTOR REARRANGEMENT SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,FCRDC,BIOL RESPONSE MODIFIERS PROGRAM,FREDERICK,MD 21702. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1674 EP A1674 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701264 ER PT J AU FERRARO, R LILLIOJA, S FONTVIEILLE, AM RISING, R RAVUSSIN, E AF FERRARO, R LILLIOJA, S FONTVIEILLE, AM RISING, R RAVUSSIN, E TI FEMALES HAVE LOWER METABOLIC RATES THAN MALES EVEN AFTER ADJUSTING FOR DIFFERENCES IN BODY-WEIGHT AND COMPOSITION SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIDDK,CLIN DIABET & NUTR SECT,PHOENIX,AZ 85016. RI Lillioja, Stephen/A-8185-2012 NR 0 TC 1 Z9 1 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1648 EP A1648 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701117 ER PT J AU FONTVIELLE, AM PETTITT, DJ RAVUSSIN, E AF FONTVIELLE, AM PETTITT, DJ RAVUSSIN, E TI PHYSICAL DEVELOPMENT, BODY-COMPOSITION AND RESTING METABOLIC-RATE (RMR) OF PIMA INDIAN AND CAUCASIAN CHILDREN SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIDDK,CLIN DIABET & NUTR SECT,PHOENIX,AZ 85016. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1648 EP A1648 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701114 ER PT J AU FOX, BA CULVER, KW FREEMAN, S KOEPLIN, D BLAESE, RM AF FOX, BA CULVER, KW FREEMAN, S KOEPLIN, D BLAESE, RM TI RETROVIRAL TRANSDUCTION WITH THE HUMAN IL-1-BETA GENE OF A CD8+ T-CELL CLONE SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV MICHIGAN,DEPT SURG,ANN ARBOR,MI 48109. NCI,METAB BRANCH,BETHESDA,MD 20892. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1463 EP A1463 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700029 ER PT J AU GALLI, SM PHILLIPS, MI AGUILERA, G AF GALLI, SM PHILLIPS, MI AGUILERA, G TI SODIUM-INTAKE MODULATES ANGIOTENSIN-II CONTENT IN HYPOTHALAMUS AND PITUITARY-GLAND BUT NOT IN THE BRAIN-STEM SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV FLORIDA,DEPT PHYSIOL,GAINESVILLE,FL 32611. NIH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1739 EP A1739 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701643 ER PT J AU GAO, B EMOTO, Y EISENBERG, E GREENE, L AF GAO, B EMOTO, Y EISENBERG, E GREENE, L TI BINDING OF CLATHRIN AND ATP TO THE BOVINE BRAIN UNCOATING ATPASE SO FASEB JOURNAL LA English DT Meeting Abstract C1 NHLBI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1559 EP A1559 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700593 ER PT J AU GHANSAH, E MALEQUE, MA KOPSOMBUT, P BROSSI, A AF GHANSAH, E MALEQUE, MA KOPSOMBUT, P BROSSI, A TI EFFECTS OF MESCALINE AND ITS ANALOGS ON CHOLINERGIC TRANSMISSION SO FASEB JOURNAL LA English DT Meeting Abstract C1 MEHARRY MED COLL,DEPT PHARMACOL,NASHVILLE,TN 37208. NIH,MED CHEM LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1598 EP A1598 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700822 ER PT J AU GLOVINSKY, D KULAGA, H ALEXANDER, R ADAMS, A COGGIANO, M TRUCKENMILLER, ME MURRAY, R WYATT, RJ KIRCH, D AF GLOVINSKY, D KULAGA, H ALEXANDER, R ADAMS, A COGGIANO, M TRUCKENMILLER, ME MURRAY, R WYATT, RJ KIRCH, D TI GENE AMPLIFICATION OF HUMAN ENDOGENOUS RETROVIRUS-LIKE SEQUENCES FROM BRAIN-TISSUE OF MULTIPLE-SCLEROSIS PATIENTS AND CONTROLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIMH,NEUROPSYCHIAT BRANCH,WASHINGTON,DC 20032. NR 0 TC 0 Z9 0 U1 1 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1661 EP A1661 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701188 ER PT J AU GOLDBERG, SR TELLA, SR SCHINDLER, CW AF GOLDBERG, SR TELLA, SR SCHINDLER, CW TI ADRENERGIC-MECHANISMS IN THE CARDIOVASCULAR EFFECTS OF COCAINE IN SQUIRREL-MONKEYS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIDA,ADDICT RES CTR,BALTIMORE,MD 21224. GEORGETOWN UNIV,SCH MED,WASHINGTON,DC 20007. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1587 EP A1587 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700759 ER PT J AU HAKIM, FT PAYNE, S MULUK, S SHEARER, GM AF HAKIM, FT PAYNE, S MULUK, S SHEARER, GM TI REDUCTION IN BONE-MARROW TRANSPLANT GVHD MORTALITY BY DEPLETION OF HOST-REACTIVE T-CELL RECEPTOR V-BETA SUBSETS FROM THE DONOR INOCULUM SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,EXPTL IMMUNOL BRANCH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1709 EP A1709 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701466 ER PT J AU HERMAN, E ZHANG, J FERRANS, V AF HERMAN, E ZHANG, J FERRANS, V TI ICRF-187, VITAMIN-A AND VITAMIN-E ATTENUATE HIGH-DOSE DOXORUBICIN TOXICITY IN BEAGLE DOGS SO FASEB JOURNAL LA English DT Meeting Abstract C1 US FDA,WASHINGTON,DC 20204. NIH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1563 EP A1563 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700616 ER PT J AU HORGAN, C BROWN, K PINCUS, S AF HORGAN, C BROWN, K PINCUS, S TI EFFECT OF IGG HINGE REGION ALTERATIONS ON THE FORMATION OF IMMOBILIZED IMMUNE-COMPLEXES SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAID,ROCKY MT LABS,HAMILTON,MT 59840. NR 1 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1670 EP A1670 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701243 ER PT J AU HU, Z ZHANG, R DUFAU, ML AF HU, Z ZHANG, R DUFAU, ML TI REGULATION OF OVARIAN PROLACTIN RECEPTOR MESSENGER-RNAS AND THEIR EXPRESSION SO FASEB JOURNAL LA English DT Meeting Abstract C1 NICHHD,ERRB,MOLEC ENDOCRINOL SECT,BETHESDA,MD 20892. NR 1 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1554 EP A1554 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700562 ER PT J AU KIANG, JG LITTEN, RZ AF KIANG, JG LITTEN, RZ TI HEAT-INDUCED HEAT-SHOCK PROTEIN 70KD PRODUCTION AND ITS EFFECT ON CYTOSOLIC FREE [CA2+] IN HUMAN EPIDERMOID A-431 CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT CLIN PHYSIOL,DIV MED,WASHINGTON,DC 20307. NIAAA,ROCKVILLE,MD 20852. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1618 EP A1618 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700938 ER PT J AU KOMORIYA, A GREEN, LJ MERVIO, MM YAMADA, SS YAMADA, KM HUMPHRIES, MJ AF KOMORIYA, A GREEN, LJ MERVIO, MM YAMADA, SS YAMADA, KM HUMPHRIES, MJ TI THE MINIMAL ESSENTIAL SEQUENCE FOR A MAJOR CELL TYPE-SPECIFIC ADHESION SITE (CS1) WITHIN THE ALTERNATIVELY SPLICED IIICS DOMAIN OF FIBRONECTIN IS LEU-ASP-VAL SO FASEB JOURNAL LA English DT Meeting Abstract C1 US FDA,CBER,DIV CYTOKINE BIOL,BETHESDA,MD 20014. UNIV MANCHESTER,DEPT BIOCHEM & MOLEC BIOL,MANCHESTER M13 9PL,LANCS,ENGLAND. NIDR,LOBA,BETHESDA,MD 20892. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1617 EP A1617 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700934 ER PT J AU KOMSCHLIES, KL DAMIA, G GREGORIO, TA MACPHEE, M RUSCETTI, F WILTROUT, RH AF KOMSCHLIES, KL DAMIA, G GREGORIO, TA MACPHEE, M RUSCETTI, F WILTROUT, RH TI INVIVO TUMORICIDAL AND IMMUNOHEMATOLOGICAL EFFECTS OF RHIL7 IN MICE SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,FREDERICK CANC RES FACIL,PRI DYNCORP & BRMP,FREDERICK,MD 21702. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1772 EP A1772 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701832 ER PT J AU KORUPOLU, GR TELLA, SR SCHINDLER, CW GOLDBERG, SR AF KORUPOLU, GR TELLA, SR SCHINDLER, CW GOLDBERG, SR TI MODIFICATION OF COCAINE-INDUCED CARDIOVASCULAR EFFECTS, CONVULSIONS AND LETHALITY BY ADRENOCEPTOR BLOCKING-AGENTS IN RATS SO FASEB JOURNAL LA English DT Meeting Abstract C1 GEORGETOWN UNIV,SCH MED,WASHINGTON,DC 20007. NIDA,ADDICT RES CTR,BALTIMORE,MD 21224. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1587 EP A1587 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700760 ER PT J AU LAUGHLIN, M BALABAN, R AF LAUGHLIN, M BALABAN, R TI INCREASED CARDIAC GLYCOGEN-SYNTHESIS OCCURS DURING RECOVERY FROM EPINEPHRINE-INDUCED WORK IN DOG HEART SO FASEB JOURNAL LA English DT Meeting Abstract C1 NHLBI,CARDIAC ENERGET LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1468 EP A1468 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700060 ER PT J AU LIN, HH KOUSVELARI, EE ANN, DK AF LIN, HH KOUSVELARI, EE ANN, DK TI CLONING, STRUCTURAL-ANALYSIS, AND EXPRESSION OF THE MACAQUE PROLINE-RICH PROTEIN GENE SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV MINNESOTA,SCH MED,DEPT PHARMACOL,MINNEAPOLIS,MN 55455. NIDR,CLIN INVEST & PATIENT CARE BRANCH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1529 EP A1529 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700417 ER PT J AU LONG, EO TELETSKI, CL WEBER, D BRAUNSTEIN, N KARP, DR AF LONG, EO TELETSKI, CL WEBER, D BRAUNSTEIN, N KARP, DR TI INTERACTIONS OF MHC CLASS-II MOLECULES WITH SUPERANTIGENS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAID,IMMUNOGENET LAB,TWINBROOK FACIL,ROCKVILLE,MD 20852. COLUMBIA UNIV,DEPT MED,NEW YORK,NY 10027. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1676 EP A1676 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701273 ER PT J AU LUBET, RA NIMS, RW JONES, CR BEEBE, LE MCBEE, K AF LUBET, RA NIMS, RW JONES, CR BEEBE, LE MCBEE, K TI THE USE OF DRUG-METABOLIZING-ENZYMES AS A MARKER OF EXPOSURE TO LOW-DOSES OF POLYCHLORINATED-BIPHENYLS (PCBS) IN RODENTS - LABORATORY AND FIELD STUDIES SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,FCRDC,COMPARAT CARCINOGENESIS LAB,FREDERICK,MD 21701. OKLAHOMA STATE UNIV,DEPT ZOOL,STILLWATER,OK 74078. NCI,FCRDC,PRI,DYNACORP,FREDERICK,MD 21701. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1517 EP A1517 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700343 ER PT J AU MARTIN, R OLSON, R COLIGAN, J FLERLAGE, M KARR, R RICHERT, J MCFARLAND, HF AF MARTIN, R OLSON, R COLIGAN, J FLERLAGE, M KARR, R RICHERT, J MCFARLAND, HF TI RECOGNITION OF MYELIN BASIC-PROTEIN PEPTIDE 87-106 BY CTL SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIB,BETHESDA,MD 20892. NINCDS,BETHESDA,MD 20892. NIAID,BETHESDA,MD 20892. UNIV IOWA,IOWA CITY,IA 52242. GEORGETOWN UNIV,WASHINGTON,DC 20007. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1679 EP A1679 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701293 ER PT J AU MCCOY, KL INMAN, J STUTZMAN, R AF MCCOY, KL INMAN, J STUTZMAN, R TI PRODUCTIVE PROCESSING OF EXOGENOUS ANTIGENS INTERNALIZED THROUGH TRANSFERRIN RECEPTORS SO FASEB JOURNAL LA English DT Meeting Abstract C1 VIRGINIA COMMONWEALTH UNIV,RICHMOND,VA 23298. NIH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1459 EP A1459 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700011 ER PT J AU METZGER, H MAO, SY EDIDIN, M AF METZGER, H MAO, SY EDIDIN, M TI ROLE OF CYTOPLASMIC DOMAINS (CDS) IN RECEPTOR MOVEMENTS - THE HIGH-AFFINITY RECEPTOR FOR IGE SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAMSD,BETHESDA,MD 20892. JOHNS HOPKINS UNIV,DEPT BIOL,BALTIMORE,MD 21218. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1625 EP A1625 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700981 ER PT J AU MILLER, DS PRITCHARD, JB AF MILLER, DS PRITCHARD, JB TI INDIRECT COUPLING OF ORGANIC ANION SECRETION TO NA IN RENAL TUBULES OF SOUTHERN FLOUNDER, PARALICHTHYS-LETHOSTIGMA SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIEHS,RES TRIANGLE PK,NC 27709. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1470 EP A1470 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700071 ER PT J AU MOSS, J TSAI, SC STANLEY, SJ AF MOSS, J TSAI, SC STANLEY, SJ TI PURIFICATION AND CHARACTERIZATION OF RAT-BRAIN ADP-RIBOSYLARGININE HYDROLASE SO FASEB JOURNAL LA English DT Meeting Abstract C1 NHLBI,CELLULAR METAB LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1506 EP A1506 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700281 ER PT J AU MULUK, S HAKIM, FT SHEARER, GM AF MULUK, S HAKIM, FT SHEARER, GM TI REGULATION OF GVHR BY MLS-REACTIVE T-CELLS IN THE DONOR POPULATION SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,EXPTL IMMUNOL BRANCH,BETHESDA,MD 20892. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1709 EP A1709 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701469 ER PT J AU MURPHY, WJ DURUM, SK LONGO, DL AF MURPHY, WJ DURUM, SK LONGO, DL TI GROWTH-HORMONE ACCELERATES PERIPHERAL T-CELL RECONSTITUTION IN MICE WITH SEVERE COMBINED IMMUNE-DEFICIENCY (SCID) SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,FCRDC,BIOL RESPONSE MODIFIERS PROGRAM,FREDERICK,MD 21702. NR 0 TC 2 Z9 2 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1669 EP A1669 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701234 ER PT J AU NISHIKATA, H KITANI, S MERGENHAGEN, SE SIRAGANIAN, RP AF NISHIKATA, H KITANI, S MERGENHAGEN, SE SIRAGANIAN, RP TI MOLECULAR-CLONING OF A CELL-SURFACE GLYCOPROTEIN AD1 THAT IS CLOSE TO THE HIGH-AFFINITY IGE RECEPTOR ON RBL-2H3 CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIDR,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1675 EP A1675 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701270 ER PT J AU ODENWALLER, R LASSMANN, G CURTIS, J MASON, RP MARNETT, LJ ELING, TE AF ODENWALLER, R LASSMANN, G CURTIS, J MASON, RP MARNETT, LJ ELING, TE TI ROLE OF PROTEIN-LINKED TYROSINE RADICALS IN PROSTAGLANDIN-H SYNTHASE ACTIVITY SO FASEB JOURNAL LA English DT Meeting Abstract C1 VANDERBILT UNIV,MED CTR,SCH MED,NASHVILLE,TN 37232. CENT INST MOLEC BIOL,BERLIN,GERMANY. NIEHS,RES TRIANGLE PK,NC 27709. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1541 EP A1541 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700489 ER PT J AU OPARA, E HUBBARD, V BURCH, W AKWARI, O AF OPARA, E HUBBARD, V BURCH, W AKWARI, O TI CHARACTERIZATION OF THE INSULINOTROPIC POTENCY OF POLYUNSATURATED FATTY-ACIDS SO FASEB JOURNAL LA English DT Meeting Abstract C1 DUKE UNIV,MED CTR,DURHAM,NC 27710. NIH,BETHESDA,MD 20892. NR 1 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1641 EP A1641 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701074 ER PT J AU PHELAN, AM COLTON, DA GILBERT, DL LANGE, DG AF PHELAN, AM COLTON, DA GILBERT, DL LANGE, DG TI ANALYSIS OF FREE-RADICAL GENERATION BY CEREBRAL MICROGLIAL CELLS USING ELECTRON-SPIN-RESONANCE SPIN TRAPPING SO FASEB JOURNAL LA English DT Meeting Abstract C1 GEORGETOWN UNIV,SCH MED,WASHINGTON,DC. JOHNS HOPKINS MED INST,BALTIMORE,MD 21205. NIH,BETHESDA,MD 20892. NR 1 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1613 EP A1613 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700910 ER PT J AU PRASAD, GL VALVERIUS, EM COOPER, HL AF PRASAD, GL VALVERIUS, EM COOPER, HL TI MOLECULAR-CLONING OF HME1, A POSSIBLE EPITHELIAL-CELL SPECIFIC PROTEIN FROM A HUMAN MAMMARY EPITHELIAL-CELL LINE SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,TUMOR IMMUNOL & BIOL LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1650 EP A1650 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701126 ER PT J AU PRITCHARD, JB WALDEN, R OIKARI, A AF PRITCHARD, JB WALDEN, R OIKARI, A TI DEHYDROABIETIC ACID (DHAA) REDUCES BOTH PARA-AMINO-HIPPURATE (PAH) TRANSPORT AND PASSIVE PERMEABILITY IN RAT RENAL MEMBRANES SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIEHS,RES TRIANGLE PK,NC 27709. UNIV JOENSUU,SF-80101 JOENSUU 10,FINLAND. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1470 EP A1470 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700072 ER PT J AU RAMKUMAR, V OLAH, ME JACOBSON, KA STILES, GL AF RAMKUMAR, V OLAH, ME JACOBSON, KA STILES, GL TI DESENSITIZATION OF DDT1 MF-2 CELLS TO R-PIA IS ASSOCIATED WITH DOWN-REGULATION AND PHOSPHORYLATION OF A1 ADENOSINE RECEPTOR SO FASEB JOURNAL LA English DT Meeting Abstract C1 DUKE UNIV,MED CTR,DEPT MED,DURHAM,NC 27710. DUKE UNIV,MED CTR,DEPT BIOCHEM,DURHAM,NC 27710. NIDDK,CHEM LAB,BETHESDA,MD 20892. RI Jacobson, Kenneth/A-1530-2009 OI Jacobson, Kenneth/0000-0001-8104-1493 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1768 EP A1768 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701810 ER PT J AU RHOADS, A VU, D WAGNER, P AF RHOADS, A VU, D WAGNER, P TI EFFECT OF FUSOGENS ON CATECHOLAMINE RELEASE FROM PERMEABILIZED PC12 CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 HOWARD UNIV,COLL MED,WASHINGTON,DC 20059. NCI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1750 EP A1750 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701704 ER PT J AU RIBAUDO, RK MARGULIES, DH AF RIBAUDO, RK MARGULIES, DH TI INVITRO TRANSLATION, FOLDING, AND ASSEMBLY OF MURINE CLASS-I MHC MOLECULES SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAID,IMMUNOL LAB,BETHESDA,MD 20892. RI Margulies, David/H-7089-2013 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1684 EP A1684 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701322 ER PT J AU RIECKMANN, P WILSON, GL HONG, JX FAUCI, AS KEHRL, JH AF RIECKMANN, P WILSON, GL HONG, JX FAUCI, AS KEHRL, JH TI THE PY BOX-B - A NEW B-CELL RESTRICTED GENE REGULATORY ELEMENT PRESENT IN THE CD20 PROMOTER SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAID,IMMUNOREGULAT LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1697 EP A1697 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701394 ER PT J AU ROHLFF, C CLAIR, T CHOCHUNG, YS AF ROHLFF, C CLAIR, T CHOCHUNG, YS TI FORMATION OF A TRUNCATED REGULATORY SUBUNIT CORRELATES THE SUPPRESSION OF TYPE-I CAMP-DEPENDENT PROTEIN-KINASE (PKA-I) IN THE 8-CL-CAMP INDUCED-DIFFERENTIATION OF HL-60 LEUKEMIA-CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,BETHESDA,MD 20892. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1530 EP A1530 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700424 ER PT J AU ROILIDES, E CLERICI, M DEPALMA, L BAKER, R PIZZO, PA SHEARER, GM AF ROILIDES, E CLERICI, M DEPALMA, L BAKER, R PIZZO, PA SHEARER, GM TI DIFFERENTIAL MATURATION OF T-HELPER CELL-FUNCTION IN NEONATES AND YOUNG-CHILDREN SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,PEDIAT BRANCH,BETHESDA,MD 20892. NCI,EXPTL IMMUNOL BRANCH,BETHESDA,MD 20892. CHILDRENS HOSP,NATL MED CTR,WASHINGTON,DC 20010. FAIRFAX HOSP,FALLS CHURCH,VA 22046. NR 0 TC 2 Z9 2 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1699 EP A1699 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701408 ER PT J AU SAFFIOTTI, U DANIEL, LN MAO, Y AHMED, N AF SAFFIOTTI, U DANIEL, LN MAO, Y AHMED, N TI DNA DAMAGE INDUCED BY COMBINED EXPOSURE TO CRYSTALLINE SILICA (CS) AND HYDROGEN-PEROXIDE SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,DEPT EXPTL PATHOL,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1603 EP A1603 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700849 ER PT J AU SAVARESE, TM WANG, CD VENTER, JC FRASER, CM AF SAVARESE, TM WANG, CD VENTER, JC FRASER, CM TI FUNCTIONAL-STUDIES ON CYSTEINE-TO-SERINE MUTANTS OF THE RAT M1 MUSCARINIC RECEPTOR SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAAA,ADAMHA,LPPS,ROCKVILLE,MD 20852. NINCDS,LMCN,BETHESDA,MD 20892. NR 1 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1586 EP A1586 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700753 ER PT J AU SCHINDLER, CW TELLA, SR KATZ, JL GOLDBERG, SR AF SCHINDLER, CW TELLA, SR KATZ, JL GOLDBERG, SR TI EFFECTS OF COCAINE AND COCAINE METHIODIDE ON CARDIOVASCULAR FUNCTION IN SQUIRREL-MONKEYS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIDA,ADDICT RES CTR,BALTIMORE,MD 21224. GEORGETOWN UNIV,SCH MED,WASHINGTON,DC 20007. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1587 EP A1587 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700756 ER PT J AU SELBY, DM SINGER, DF SOLVAY, MJ BEKTAS, A ANDERSON, RW LINDERMAN, JJ COLIGAN, JE NAIM, R AF SELBY, DM SINGER, DF SOLVAY, MJ BEKTAS, A ANDERSON, RW LINDERMAN, JJ COLIGAN, JE NAIM, R TI EARLY EVENTS IN PEPTIDE ANTIGEN HANDLING BY ANTIGEN PRESENTING CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV MICHIGAN,ANN ARBOR,MI 48109. NIAID,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1460 EP A1460 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700013 ER PT J AU SHER, A DELACRUZ, VF STOVER, CK BURLEIN, JE JAMES, SL YOUNG, JF PEARCE, EJ AF SHER, A DELACRUZ, VF STOVER, CK BURLEIN, JE JAMES, SL YOUNG, JF PEARCE, EJ TI SELECTIVE INDUCTION OF TH1 CYTOKINE RESPONSES BY A SCHISTOSOME PARAMYOSIN-BCG RECOMBINANT VACCINE SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAID,BETHESDA,MD 20892. MEDIMMUNE INC,GAITHERSBURG,MD 20878. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1672 EP A1672 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701253 ER PT J AU SHIMIZU, Y SHAW, S GRABER, N GOPAL, V HORGAN, KJ VANSEVENTER, GA NEWMAN, W AF SHIMIZU, Y SHAW, S GRABER, N GOPAL, V HORGAN, KJ VANSEVENTER, GA NEWMAN, W TI ACTIVATION-INDEPENDENT ADHESION OF CD4+CD45RO+ MEMORY T-CELLS TO ELAM-1 SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,EIB,BETHESDA,MD 20892. OTSUKA AMER PHARMACEUT INC,DEPT MOLEC BIOL,ROCKVILLE,MD. OTSUKA AMER PHARMACEUT INC,DEPT IMMUNOL,ROCKVILLE,MD. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1687 EP A1687 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701339 ER PT J AU SMITH, TJ GUO, Z STONER, GD GONZALEZ, FJ YANG, CS AF SMITH, TJ GUO, Z STONER, GD GONZALEZ, FJ YANG, CS TI METABOLISM OF 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE (NNK) IN HUMAN LUNG MICROSOMES AND CYTOCHROMES-P450 EXPRESSED HEP G2 CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 RUTGERS STATE UNIV,COLL PHARM,CANC RES LAB,PISCATAWAY,NJ 08855. MED COLL OHIO,DEPT PATHOL,TOLEDO,OH 43699. NCI,MOLEC CARCINOGENESIS LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1516 EP A1516 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700338 ER PT J AU SOBOL, RW WILSON, SH KUMAR, A LEE, BJ HATFIELD, DL CHARUBALA, R PFLEIDERER, W SUHADOLNIK, RJ AF SOBOL, RW WILSON, SH KUMAR, A LEE, BJ HATFIELD, DL CHARUBALA, R PFLEIDERER, W SUHADOLNIK, RJ TI 2',5'-OLIGOADENYLATE MEDIATED INHIBITION OF HIV-1 REVERSE-TRANSCRIPTASE SO FASEB JOURNAL LA English DT Meeting Abstract C1 TEMPLE UNIV,HLTH SCI CTR,SCH MED,PHILADELPHIA,PA 19140. NCI,BETHESDA,MD 20892. UNIV CONSTANCE,W-7750 CONSTANCE,GERMANY. RI Sobol, Robert/E-4125-2013 OI Sobol, Robert/0000-0001-7385-3563 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1556 EP A1556 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700576 ER PT J AU STEPHAN, V BENHAMOU, M GUTKIND, SJ ROBBINS, KC SIRAGANIAN, RP AF STEPHAN, V BENHAMOU, M GUTKIND, SJ ROBBINS, KC SIRAGANIAN, RP TI IGE-MEDIATED TYROSINE PHOSPHORYLATION IN RBL-2H3 CELLS - RELATIONSHIP TO GTP-BINDING PROTEIN-ACTIVATION AND PHOSPHOINOSITOL (PI) HYDROLYSIS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIDR,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1676 EP A1676 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701275 ER PT J AU STOJILKOVIC, SS IIDA, T IZUMI, SI CATT, KJ AF STOJILKOVIC, SS IIDA, T IZUMI, SI CATT, KJ TI SPONTANEOUS AND AGONIST-INDUCED OSCILLATIONS OF INTRACELLULAR CALCIUM AND SECRETORY RESPONSES OF PITUITARY GONADOTROPHS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NICHHD,ENDOCRINOL & REPROD RES BRANCH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1597 EP A1597 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700815 ER PT J AU TAKACS, L GOTLIEB, WH BRISTOL, LA DURUM, SK WEISSMAN, A AF TAKACS, L GOTLIEB, WH BRISTOL, LA DURUM, SK WEISSMAN, A TI IL-2 SELECTIVELY UP-REGULATES TCR GAMMA CHAIN GENE-TRANSCRIPTION IN RAT GAMMA-DELTA-T-CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAAA,LPPS,ROCKVILLE,MD 20852. NCI,EIB,BETHESDA,MD 20892. PROGRAM RESOURCES INC,LMI,ROCKVILLE,MD. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1698 EP A1698 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701400 ER PT J AU TANAKA, Y HORGAN, KJ LUCE, GEG SHAW, S AF TANAKA, Y HORGAN, KJ LUCE, GEG SHAW, S TI CD45 ISOFORMS OF HUMAN CIRCULATING AND LYMPHOID-TISSUE CD8+ T-CELLS INDICATE MUCH FEWER MEMORY CELLS THAN CD4+ T-CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,EIB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1687 EP A1687 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701335 ER PT J AU TELLA, SR SCHINDLER, CW KORUPOLU, GR GOLDBERG, SR AF TELLA, SR SCHINDLER, CW KORUPOLU, GR GOLDBERG, SR TI VARIABLE DEGREE OF ANTAGONISM OF CARDIOVASCULAR EFFECTS OF COCAINE BY GANGLIONIC BLOCKERS IN CONSCIOUS RATS SO FASEB JOURNAL LA English DT Meeting Abstract C1 GEORGETOWN UNIV,SCH MED,WASHINGTON,DC 20007. NIDA,ADDICT RES CTR,BALTIMORE,MD 21224. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1587 EP A1587 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700757 ER PT J AU TOLLERUD, D BROWN, L BLATTNER, W MANN, D PANKIWTROST, L HOOVER, R AF TOLLERUD, D BROWN, L BLATTNER, W MANN, D PANKIWTROST, L HOOVER, R TI EVIDENCE FOR THE INFLUENCE OF RACE ON T-CELL SUBSET ALTERATIONS ASSOCIATED WITH CIGARETTE-SMOKING SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV PITTSBURGH,PITTSBURGH,PA 15260. NCI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1687 EP A1687 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701340 ER PT J AU TSAIMORRIS, CH BUCZKO, E WEI, W XIE, XZ DUFAU, ML AF TSAIMORRIS, CH BUCZKO, E WEI, W XIE, XZ DUFAU, ML TI STRUCTURAL ORGANIZATION OF THE RAT LUTEINIZING-HORMONE RECEPTOR GENE SO FASEB JOURNAL LA English DT Meeting Abstract C1 NICHHD,ERRB,MOLEC ENDOCRINOL SECT,BETHESDA,MD 20892. NR 1 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1554 EP A1554 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700561 ER PT J AU TSUTSUMI, K SAAVEDRA, JM AF TSUTSUMI, K SAAVEDRA, JM TI CHARACTERIZATION AND DEVELOPMENT OF ANGIOTENSIN-II RECEPTOR SUBTYPES IN RAT-BRAIN SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIMH,CLIN SCI LAB,PHARMACOL SECT,BETHESDA,MD 20892. NR 0 TC 2 Z9 2 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1740 EP A1740 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701652 ER PT J AU VASILE, S SOOD, AK COLIGAN, JE SEON, BK AF VASILE, S SOOD, AK COLIGAN, JE SEON, BK TI THE ALTERNATIVELY SPLICED HLA-DQ-BETA MESSENGER-RNA LACKING THE TRANSMEMBRANE DOMAIN IS DETECTED IN HUMAN LEUKEMIA-CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAID,BETHESDA,MD 20892. ROSWELL PK CANC INST,BUFFALO,NY 14263. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1684 EP A1684 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701318 ER PT J AU VELOSO, D DENNY, S MCKEE, K HOCHSTEIN, DH AF VELOSO, D DENNY, S MCKEE, K HOCHSTEIN, DH TI IRREVERSIBLE SHOCK IN ENDOTOXIN-TREATED RHESUS MACAQUES CORRELATES WITH PROLONGED HIGH PLASMA-LEVELS OF TUMOR-NECROSIS-FACTOR (TNF) SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. NIH,CBER,BETHESDA,MD 20892. NR 0 TC 2 Z9 2 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1619 EP A1619 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700944 ER PT J AU VOSTAL, JG JACKSON, WL SHULMAN, NR AF VOSTAL, JG JACKSON, WL SHULMAN, NR TI CYTOSOLIC AND STORED CALCIUM ANTAGONISTICALLY CONTROL TYROSINE PHOSPHORYLATION (TP) OF SPECIFIC PLATELET PROTEINS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIDDK,CLIN HEMATOL BRANCH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1469 EP A1469 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700064 ER PT J AU WADHWANI, KC SHIMONHOPHY, M RAPOPORT, SI AF WADHWANI, KC SHIMONHOPHY, M RAPOPORT, SI TI BLOOD-NERVE BARRIER PERMEABILITIES TO CATIONIZED SERUM ALBUMINS IN AWAKE RATS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIA,NEUROSCI LAB,BETHESDA,MD 20892. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1473 EP A1473 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700091 ER PT J AU WILDE, DB EZQUERRA, A ROBERTS, K MCCONNELL, TJ COLIGAN, JE SHEVACH, EM AF WILDE, DB EZQUERRA, A ROBERTS, K MCCONNELL, TJ COLIGAN, JE SHEVACH, EM TI FUNCTIONAL AND MOLECULAR STUDIES OF GAMMA-DELTA-T-CELLS WHICH CONSTITUTIVELY SECRETE CYTOKINES SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAID,LI,BETHESDA,MD 20892. NIAID,BRB,BETHESDA,MD 20892. RI Ezquerra, Angel/I-3440-2012 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1689 EP A1689 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701349 ER PT J AU WILLIAMS, WM RAPOPORT, SI AF WILLIAMS, WM RAPOPORT, SI TI PHOSPHOLIPID-COMPOSITION AND AGING IN MOUSE-BRAIN MICROVESSELS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIA,NEUROSCI LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1734 EP A1734 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701616 ER PT J AU WILSON, GL FAUCI, AS KEHRL, JH AF WILSON, GL FAUCI, AS KEHRL, JH TI ISOLATION AND CHARACTERIZATION OF CDNA AND GENOMIC CLONES FOR THE B-CELL MEMBRANE PROTEIN-CD22 SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAID,IMMUNOREGULAT LAB,BETHESDA,MD 20892. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1696 EP A1696 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701393 ER PT J AU WU, XM CHOCK, PB AF WU, XM CHOCK, PB TI A METHOD FOR DIFFERENTIATING BETWEEN A DISSOCIATIVE AND AN ASSOCIATIVE MECHANISM IN LIGAND-EXCHANGE REACTIONS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NHLBI,BIOCHEM LAB,BETHESDA,MD 20892. NR 3 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1514 EP A1514 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700325 ER PT J AU YANNELLI, JR ROSENBERG, SA AF YANNELLI, JR ROSENBERG, SA TI CLONING OF TUMOR INFILTRATING LYMPHOCYTES (TIL) FROM LIVER METASTASES OF COLON ADENOCARCINOMAS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,SURG BRANCH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1712 EP A1712 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701483 ER PT J AU YAMADA, M MIZUGUCHI, M RHEE, SG KIM, SU AF YAMADA, M MIZUGUCHI, M RHEE, SG KIM, SU TI DEVELOPMENTAL-CHANGES OF 3 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE-C ISOZYMES IN THE RAT NERVOUS-SYSTEM SO DEVELOPMENTAL BRAIN RESEARCH LA English DT Article DE PHOSPHOINOSITIDE SECOND-MESSENGER SYSTEM; RAT; CENTRAL NERVOUS SYSTEM; IMMUNOHISTOCHEMISTRY ID PROTEIN-KINASE-C; BOVINE BRAIN; IMMUNOHISTOCHEMICAL LOCALIZATION; TYROSINE PHOSPHORYLATION; INSITU HYBRIDIZATION; CELL MIGRATION; RHESUS-MONKEY; GLIAL-CELLS; EXPRESSION; NEURONS AB Developmental changes of 3 phosphoinositide-specific phospholipase C isozymes (PI-PLC-beta, PI-PLC-gamma and PI-PLC-delta) in the rat nervous system were studied by immunohistochemical and immunochemical methods. PI-PLC-gamma immunoreactivity was intensely expressed in the radial fibres from the late fetal to early newborn stages, while weaker PI-PLC-beta reaction was also demonstrated in these structures. PI-PLC-beta and PI-PLC-gamma immunoreactivity appeared in neurons of various regions after the first postnatal week and then increased to the adult stage. Bergmann glia and some astrocytes also showed weak immunoreactivity for both isozymes from the newborn stage, while such immunoreactive astrocytes were relatively restricted in distribution in the white matter and hippocampus at the adult stage. PI-PLC-delta immunoreactivity appeared in astrocytes of entire cerebral regions from the second postnatal week, although weak antigenicity was also present in some neurons. Immunoblot analysis revealed that the immunoreactivities of 3 PI-PLC isozymes were present in both fetal and adult brains, with strong reactions of PI-PLC-beta and PI-PLC-delta in adult brain and that of PI-PLC-gamma in fetal brain. These results suggest that each PI-PLC isozyme plays important roles in different cell types in the course of their differentiation, and that some PI-PLC isozymes, especially PI-PLC-gamma, may be involved in cellular division and growth during the histogenesis of the central nervous system. C1 UNIV BRITISH COLUMBIA,DEPT MED,DIV NEUROL,2211 WESBROOK MALL,VANCOUVER V6T 1W5,BC,CANADA. NHLBI,BIOCHEM LAB,BETHESDA,MD 20892. NR 35 TC 25 Z9 25 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-3806 J9 DEV BRAIN RES JI Dev. Brain Res. PD MAR 18 PY 1991 VL 59 IS 1 BP 7 EP 16 DI 10.1016/0165-3806(91)90023-C PG 10 WC Developmental Biology; Neurosciences SC Developmental Biology; Neurosciences & Neurology GA FE414 UT WOS:A1991FE41400002 ER PT J AU LAUGHLIN, T WAAG, D WILLIAMS, J MARRIE, T AF LAUGHLIN, T WAAG, D WILLIAMS, J MARRIE, T TI Q-FEVER - FROM DEER TO DOG TO MAN SO LANCET LA English DT Letter C1 USA,MED RES INST INFECT DIS,DIV BACTERIOL,FREDERICK,MD 21701. NIAID,BETHESDA,MD 20892. DALHOUSIE UNIV,DEPT MED,HALIFAX B3H 2Y9,NS,CANADA. DALHOUSIE UNIV,DEPT MICROBIOL,HALIFAX B3H 2Y9,NS,CANADA. RP LAUGHLIN, T (reprint author), MONCTON CITY HOSP,DEPT FAMILY PRACTICE,MONCTON,NB,CANADA. NR 2 TC 24 Z9 26 U1 0 U2 1 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0140-6736 J9 LANCET JI Lancet PD MAR 16 PY 1991 VL 337 IS 8742 BP 676 EP 677 DI 10.1016/0140-6736(91)92494-M PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA FB730 UT WOS:A1991FB73000039 PM 1672016 ER PT J AU JUPP, PG PURCELL, RH PHILLIPS, JM SHAPIRO, M GERIN, JL AF JUPP, PG PURCELL, RH PHILLIPS, JM SHAPIRO, M GERIN, JL TI ATTEMPTS TO TRANSMIT HEPATITIS-B VIRUS TO CHIMPANZEES BY ARTHROPODS SO SOUTH AFRICAN MEDICAL JOURNAL LA English DT Article ID CIMEX-LECTULARIUS L; SURFACE-ANTIGEN; ORNITHODOROS-MOUBATA; HEMIPTERUS FABR; SOUTH-AFRICA; PREVALENCE; INFECTION; KAVANGO; NAMIBIA; SENEGAL AB Bedbugs (Cimex lectularius L.) were fed on an infective blood-hepatitis B virus (HBV) mixture. Further bedbugs and tampan ticks (Ornithodoros moubata [Murray]) were fed on HBV-carrier chimpanzees. After a 10 - 13 day interval for oviposition, tests done on samples of individual arthropods showed that 53 - 85% of the bugs were HBsAg-positive and none HBeAg-positive, while 100% of the ticks were HBsAg-positive and 88% HBeAg-positive. The remaining arthropods were fed on 3 susceptible chimpanzees, which had failed to develop HBV infection after 11 months, indicating no transmission had occurred. Subsequently the presence of viable virus in the original infective meals was confirmed by inoculation of the relevant donor sera directly into the 3 still susceptible chimpanzees. HBV infections quickly followed in each animal. It is concluded that, while mechanical transmission of HBV is most unlikely after a 10 - 13-day interval between feedings in bedbugs and tampans, it is still possible that mechanical transmission between humans might occur during interrupted feeds. C1 NIAID,BETHESDA,MD 20892. SEMA INC,PRIMATE CTR,ROCKVILLE,MD. GEORGETOWN UNIV,MED CTR,DIV MOLEC VIROL & IMMUNOL,WASHINGTON,DC 20007. RP JUPP, PG (reprint author), UNIV WITWATERSRAND,NATL INST VIROL,DEPT VIROL,ARBOVIRUS UNIT,JOHANNESBURG 2001,SOUTH AFRICA. FU PHS HHS [1-A1-72623, 1-A1-52567] NR 19 TC 16 Z9 19 U1 0 U2 5 PU MED ASSOC S AFRICA PI JOHANNESBURG PA MED HOUSE CENTRAL SQ 7430 PINELANDS JOHANNESBURG, SOUTH AFRICA SN 0038-2469 J9 S AFR MED J JI S. Afr. Med. J. PD MAR 16 PY 1991 VL 79 IS 6 BP 320 EP 322 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA FD291 UT WOS:A1991FD29100013 PM 2017742 ER PT J AU ROSSIER, MF BIRD, GS PUTNEY, JW AF ROSSIER, MF BIRD, GS PUTNEY, JW TI SUBCELLULAR-DISTRIBUTION OF THE CALCIUM-STORING INOSITOL 1,4,5-TRISPHOSPHATE-SENSITIVE ORGANELLE IN RAT-LIVER - POSSIBLE LINKAGE TO THE PLASMA-MEMBRANE THROUGH THE ACTIN MICROFILAMENTS SO BIOCHEMICAL JOURNAL LA English DT Article ID BOVINE ADRENAL-CORTEX; PAROTID ACINAR-CELLS; ENDOPLASMIC-RETICULUM; CA-2+ RELEASE; TRISPHOSPHATE RECEPTOR; INTRACELLULAR CALCIUM; MICROSOMAL FRACTIONS; GUANINE-NUCLEOTIDE; HUMAN-NEUTROPHILS; SMOOTH-MUSCLE AB The role of Ins(1,4,5)P3 in the mobilization of Ca2+ from intracellular stores of non-muscle cells has been extensively demonstrated; however, the nature of the organelle releasing the Ca2+ is still poorly understood. The distributions of the Ins(1,4,5)P3-binding sites and of the Ins(1,4,5)P3-sensitive Ca2+ pool were investigated in subcellular fractions obtained from rat liver and compared with those of other markers. The Ins(1,4,5)P3-binding vesicles appeared to be completely distinct from the endoplasmic-reticulum-derived microsomes and were enriched in the same fractions which were enriched in alkaline phosphodiesterase I activity. This co-purification of the plasma-membrane marker with the Ins(1,4,5)P3-binding sites was dramatically altered after freezing or after treatment of the homogenate with the microfilament-disruptive drug cytochalasin B, suggesting that the Ins(1,4,5)P3-sensitive organelle may be linked to the plasma membrane through the actin microfilaments. No correlation was observed between the Ins(1,4,5)P3-binding capacity and the portion of the Ca2+ pool that was released by Ins(1,4,5)P3. This may result from the disruption of the native organelle during homogenization, leading to the formation of vesicles containing the Ins(1,4,5)P3 receptor, but lacking the Ca2+ pump. These results are consistent with the idea of a specialized Ins(1,4,5)P3-regulated organelle distinct from the endoplasmic reticulum, and we propose a model of the structural organization of this organelle, in which the anchorage to the cytoskeleton as well as the spatial separation of the Ca2+ pump from the Ins(1,4,5)P3 receptor have important functional significance. RP ROSSIER, MF (reprint author), NIEHS,CELLULAR & MOLEC PHARMACOL LAB,RES TRIANGLE PK,NC 27709, USA. NR 62 TC 150 Z9 151 U1 0 U2 1 PU PORTLAND PRESS PI LONDON PA 59 PORTLAND PLACE, LONDON, ENGLAND W1N 3AJ SN 0264-6021 J9 BIOCHEM J JI Biochem. J. PD MAR 15 PY 1991 VL 274 BP 643 EP 650 PN 3 PG 8 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA FD379 UT WOS:A1991FD37900002 PM 1849402 ER PT J AU SHACTER, E LOPEZ, RL PATI, S AF SHACTER, E LOPEZ, RL PATI, S TI INHIBITION OF THE MYELOPEROXIDASE-H2O2-CL- SYSTEM OF NEUTROPHILS BY INDOMETHACIN AND OTHER NONSTEROIDAL ANTIINFLAMMATORY DRUGS SO BIOCHEMICAL PHARMACOLOGY LA English DT Article ID NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ENHANCED CHEMI-LUMINESCENCE; ASPIRIN-LIKE DRUGS; SUPEROXIDE PRODUCTION; HYDROGEN-PEROXIDE; RHEUMATOID-ARTHRITIS; HYPOCHLOROUS ACID; ARACHIDONIC-ACID; POLYMORPHONUCLEAR LEUKOCYTES; CYCLO-OXYGENASE AB The results presented herein demonstrate that the non-steroidal anti-inflammatory drug (NSAID) indomethacin is a strong inhibitor of the formation of HOCl by murine neutrophils (50% inhibition at 15-mu-M). Addition of 40-mu-M indomethacin to activated neutrophils caused 80% inhibition of HOCl formation throughout a 60-min time course while slightly increasing the levels of O2- and H2O2 produced. Comparable degrees of inhibition were achieved when the cells were stimulated with phorbol myristate acetate and with opsonized zymosan. Control experiments indicated that the drug did not act by scavenging HOCl. Direct inhibition of the chlorinating activity of myeloperoxidase (MPO) was confirmed using highly purified human enzyme in vitro. Kinetic analysis of the mechanism of inhibition showed that the drug was competitive with respect to Cl- and uncompetitive with respect to H2O2, showing a K(i) of 37-mu-M. In contrast to its inhibition of the oxidation of Cl- by MPO, indomethacin had no effect on the peroxidative activity of the enzyme (oxidation of 4-aminoantipyrene), nor did it inhibit the activity of several other enzymes involved in H2O2 metabolism, including horseradish peroxidase, catalase, xanthine oxidase, and superoxide dismutase. Finally, it was found that inhibition of HOCl formation was a shared but non-uniform property of many NSAIDs; piroxicam, salicylate, sulindac, ibuprofen, and aspirin were all inhibitory but at widely different concentrations [K(i)(app) values of 0.05, 0.18, 0.18, > 1, and 3 mM respectively] that correlated only partially with their therapeutic dose range. The results encourage further studies into the possibility that inhibition of HOCl formation may constitute an additional mechanism whereby NSAIDs reduce tissue distruction in chronically inflamed tissues. RP SHACTER, E (reprint author), NCI,GENET LAB,BLDG 37,RM 2B-03,BETHESDA,MD 20892, USA. NR 77 TC 68 Z9 68 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0006-2952 J9 BIOCHEM PHARMACOL JI Biochem. Pharmacol. PD MAR 15 PY 1991 VL 41 IS 6-7 BP 975 EP 984 DI 10.1016/0006-2952(91)90204-I PG 10 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA FD172 UT WOS:A1991FD17200018 PM 1848981 ER PT J AU GLOVER, CJ TELLEZ, MR GUZIEC, FS FELSTED, RL AF GLOVER, CJ TELLEZ, MR GUZIEC, FS FELSTED, RL TI SYNTHESIS AND CHARACTERIZATION OF INHIBITORS OF MYRISTOYL-COA-PROTEIN N-MYRISTOYLTRANSFERASE SO BIOCHEMICAL PHARMACOLOGY LA English DT Article ID MURINE LEUKEMIA-VIRUS; NH2-TERMINAL BLOCKING GROUP; ROUS-SARCOMA VIRUS; T-CELL LEUKEMIA; MORPHOLOGICAL TRANSFORMATION; GLYCINAL DIETHYLACETAL; MEMBRANE ASSOCIATION; POLYOMA-VIRUS; GAG PRECURSOR; ACID AB Several substrate and product analogs were synthesized and tested as in vitro inhibitors of bovine brain N-myristoyl-CoA:protein N-myristoyltransferase (NMT; EC 2.3.1.97). At 40-mu-M, the acyl CoA analog, S-(2-ketopentadecyl)-CoA, completely inhibited NMT in the presence of 80-mu-M myristoyl CoA. Decreasing but marked inhibition was also observed with the acyl CoA analogs, S-(2-bromotetradecanoyl)-CoA and S-(3-epoxymethylene)dodecanoyl)-CoA, and the multisubstrate derivative N-(2-S-CoA-tetradecanoyl)glycinamide in the presence of 40-mu-M myristoyl CoA. Inhibition was also observed with the non-coenzyme A myristoyl analog, 1-bromo-2-pentadecanone. All of the above compounds exhibited reversible competitive inhibition kinetics with respect to myristoyl CoA with K(i) values of 0.11 to 24-mu-M. Two additional acyl CoA analogs, S-(cis-3-tetradecenoyl)-CoA and S-(3-tetradecynoyl)-CoA, functioned as alternative substrates for NMT. C1 NEW MEXICO STATE UNIV,DEPT CHEM,LAS CRUCES,NM 88003. RP GLOVER, CJ (reprint author), NCI,DIV CANC TREATMENT,BIOL CHEM LAB,BLDG 37,RM 5D02,BETHESDA,MD 20892, USA. FU NCI NIH HHS [N01-CM-87278, N01-CM-67872, N01-CM-67866] NR 53 TC 15 Z9 15 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0006-2952 J9 BIOCHEM PHARMACOL JI Biochem. Pharmacol. PD MAR 15 PY 1991 VL 41 IS 6-7 BP 1067 EP 1074 DI 10.1016/0006-2952(91)90215-Q PG 8 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA FD172 UT WOS:A1991FD17200029 PM 2009075 ER PT J AU LEVENDOSKY, AA JOSEPHVANDERPOOL, JR HARDIN, T SOREK, E ROSENTHAL, NE AF LEVENDOSKY, AA JOSEPHVANDERPOOL, JR HARDIN, T SOREK, E ROSENTHAL, NE TI CORE BODY-TEMPERATURE IN PATIENTS WITH SEASONAL AFFECTIVE-DISORDER AND NORMAL CONTROLS IN SUMMER AND WINTER SO BIOLOGICAL PSYCHIATRY LA English DT Article ID CIRCADIAN-RHYTHMS; MELATONIN; CORTISOL AB The rationale for phototherapy in seasonal affective disorder (SAD) was originally based on the notion that SAD patients were light deprived during the wintertime and needed more light. We previously found normal temperature profiles of untreated SAD patients during the winter, and that phototherapy significantly enhanced the amplitude of the circadian temperature profile in SAD patients during the winter (Rosenthal et al 1990). We hypothesized that summer would act similarly on the temperature rhythm of these patients. In this study we examined the temperature data from SAD patients and normal controls during the summer and compared it to the results of our previous study. We found identical profiles for SAD patients and normal controls during the summer and that summer significantly lowered the overall temperature profiles of both groups and did not alter the amplitudes. These results raise questions about the validity of the current theories of the mechanism of light therapy. C1 NIH,CLIN CTR NURSING DEPT,BETHESDA,MD 20892. RP LEVENDOSKY, AA (reprint author), NIMH,CLIN PSYCHOBIOL BRANCH,BLDG 10-4S-239,9000 ROCKVILLE PIKE,BETHESDA,MD 20892, USA. NR 30 TC 23 Z9 23 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0006-3223 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD MAR 15 PY 1991 VL 29 IS 6 BP 524 EP 534 DI 10.1016/0006-3223(91)90089-5 PG 11 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA FG088 UT WOS:A1991FG08800002 PM 2054429 ER PT J AU FALK, LA DEBENEDETTI, F LOHREY, N BIRCHENALLROBERTS, MC ELLINGSWORTH, LW FALTYNEK, CR RUSCETTI, FW AF FALK, LA DEBENEDETTI, F LOHREY, N BIRCHENALLROBERTS, MC ELLINGSWORTH, LW FALTYNEK, CR RUSCETTI, FW TI INDUCTION OF TRANSFORMING GROWTH FACTOR-BETA-1 (TGF-BETA-1) RECEPTOR EXPRESSION AND TGF-BETA-1 PROTEIN-PRODUCTION IN RETINOIC ACID-TREATED HL-60 CELLS - POSSIBLE TGF-BETA-1-MEDIATED AUTOCRINE INHIBITION SO BLOOD LA English DT Article ID TUMOR NECROSIS FACTOR; HEMATOPOIETIC PROGENITOR CELLS; ACUTE PROMYELOCYTIC LEUKEMIA; FACTOR-BETA; LINE HL-60; TERMINAL DIFFERENTIATION; IMMUNE INTERFERON; INVITRO; LYMPHOTOXIN; SEQUENCE C1 COLLAGEN CORP,PALO ALTO,CA. RP FALK, LA (reprint author), NCI,FREDERICK CANC RES & DEV CTR,DYN CORP,PROGRAM RESOURCES INC,FREDERICK,MD 21702, USA. OI De Benedetti, fabrizio/0000-0001-8749-8232 FU NCI NIH HHS [N01-CO-74102] NR 38 TC 109 Z9 111 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD MAR 15 PY 1991 VL 77 IS 6 BP 1248 EP 1255 PG 8 WC Hematology SC Hematology GA FB731 UT WOS:A1991FB73100017 PM 1848114 ER PT J AU LAROCCA, RV STEIN, CA DANESI, R COOPER, MR UHRICH, M MYERS, CE AF LAROCCA, RV STEIN, CA DANESI, R COOPER, MR UHRICH, M MYERS, CE TI A PILOT-STUDY OF SURAMIN IN THE TREATMENT OF METASTATIC RENAL-CELL CARCINOMA SO CANCER LA English DT Article ID GROWTH-FACTOR; KIDNEY; INHIBITION; BINDING; BLADDER; HEPARIN; CANCER AB Suramin sodium is an aromatic polysulfonated compound that was originally introduced as an antiparastic agent in the 1920s. Recently, in view of its ability to bind and disrupt the function of multiple growth factors and cellular enzyme systems, the authors have been evaluating the role of suramin as an antitumor agent. In this study, 12 patients with metastatic renal cell carcinoma received parenteral suramin by continuous infusion to a peak plasma suramin level greater than 200-mu-g/ml. No objective radiographic responses were observed, although greater than 90% necrosis of multiple tumor sites was documented at autopsy in one patient and normalization of tumor-related hypercalcemia occurred in another patient. Two patients had stable disease of 10 and 28 weeks' duration, respectively. Significant toxicities included hypotension related to sepsis and resulting in renal insufficiency (one patient), development of liver function abnormalities (one patient), marked thrombocytopenia (one patient), prothrombin time prolongation (all patients), vortex keratopathy (two patients), and Grade 1 sensory neuropathy (two patients). On this basis of the current results, suramin does not appear to be an active single agent against metastatic renal cell carcinoma when administered by this dosing schedule. RP LAROCCA, RV (reprint author), NCI,DIV CANC TREATMENT,CLIN ONCOL PROGRAM,MED BRANCH,BLDG 10,ROOM 12N-226,BETHESDA,MD 20892, USA. NR 24 TC 45 Z9 45 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD MAR 15 PY 1991 VL 67 IS 6 BP 1509 EP 1513 DI 10.1002/1097-0142(19910315)67:6<1509::AID-CNCR2820670608>3.0.CO;2-F PG 5 WC Oncology SC Oncology GA FC040 UT WOS:A1991FC04000007 PM 2001538 ER PT J AU AXIOTIS, CA MERINO, MJ DURAY, PH AF AXIOTIS, CA MERINO, MJ DURAY, PH TI LANGERHANS CELL HISTIOCYTOSIS OF THE FEMALE GENITAL-TRACT SO CANCER LA English DT Article ID CERVICAL INTRAEPITHELIAL NEOPLASIA; MULTIFOCAL EOSINOPHILIC GRANULOMA; WART VIRUS-INFECTION; DENDRITIC CELLS; MONOCLONAL-ANTIBODIES; PROGNOSIS; ANTIGEN; TRANSFORMATION; LYMPHOCYTES; EPITHELIUM AB Langerhans cell histiocytosis (LCH) of the female genital tract is rare. Four new cases are reported, and there is a review of the 38 cases in the literature. This disease may involve the vulva, vagina, cervix, endometrium, and ovary. Four distinct patient groups, segregated on the basis of initial presentation and subsequent anatomic extent of disease, were categorized as follows: (1) "pure" genital LCH, (2) genital LCH with subsequent multi-organ involvement, (3) oral or cutaneous LCH with subsequent genital and multi-organ involvement, and (4) diabetes insipidus with subsequent genital and multi-organ disease. Although involvement of the genital tract can occur at any age, it is most common in young adulthood. Clinically, LCH may mimic either primary neoplasia or various inflammatory lesions; the major pathologic differential diagnosis is venereal and other inflammatory diseases. The pure genital form may have a distinct nosologic position in the spectrum of LCH similar to the "pure," self-limited cutaneous histiocytosis seen in infants. There is no correlation between histologic findings and the outcome of the genital lesions. There is also no correlation between clinical presentation and/or the extent of involvement and outcome of genital lesions; complete regression, partial improvement, persistent lesions, and recurrences were seen in all four groups of patients. The treatment of genital LCH is not well defined and is highly individualized. Therapy has included surgery, radiation, topical corticosteroids, topical nitrogen mustard, systemic chemotherapy, and combination therapy; mixed results were obtained with all treatment modalities. Although no modality has been shown to yield a superior outcome, complete surgical excision is advocated as initial therapy. C1 WARREN GRANT MAGNUSON CLIN CTR,OFF DIRECTOR,BETHESDA,MD. FOX CHASE CANC INST,DEPT PATHOL,PHILADELPHIA,PA 19111. RP AXIOTIS, CA (reprint author), NCI,DEPT PATHOL,BLDG 10,ROOM 2N212,BETHESDA,MD 20892, USA. NR 78 TC 47 Z9 52 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD MAR 15 PY 1991 VL 67 IS 6 BP 1650 EP 1660 DI 10.1002/1097-0142(19910315)67:6<1650::AID-CNCR2820670629>3.0.CO;2-T PG 11 WC Oncology SC Oncology GA FC040 UT WOS:A1991FC04000028 PM 2001554 ER PT J AU AKIBA, S NERIISHI, K BLOT, WJ KABUTO, M STEVENS, RG KATO, H LAND, CE AF AKIBA, S NERIISHI, K BLOT, WJ KABUTO, M STEVENS, RG KATO, H LAND, CE TI SERUM FERRITIN AND STOMACH-CANCER RISK AMONG A JAPANESE POPULATION SO CANCER LA English DT Article ID BODY IRON STORES; CARCINOMA AB Using stored serum samples collected during from 1970 to 1972 and/or 1977 to 1979 from a fixed population in Hiroshima and Nagasaki, Japan, serum ferritin, transferrin, and ceruloplasmin levels were determined immunologically for persons in whom stomach (233 cases) or lung cancer (84 cases) subsequently developed as well as for their controls. An elevated stomach cancer risk was associated with low antecedent serum ferritin levels, with more than a threefold excess among those in the lowest compared with the highest ferritin quintile. The risk did not vary with the time between blood collection and stomach cancer onset, remaining high among those with low ferritin levels 5 or more years before cancer diagnosis. Achlorhydria, diagnosed in a sample of the population about 10 years before the 1970-to-1972 blood collection and up to 25 years before cancer, was an independent marker of stomach cancer risk. In combination, low serum ferritin and achlorhydria were associated with a tenfold increase in the subsequent risk. No effect of transferrin or ceruloplasmin, independent of ferritin, was observed in the gastric cancer risk, and the risk of lung cancer was not related to these three serum proteins. These prospective findings indicate that biologic markers of an increased risk of stomach cancer can be detected long before cancer onset. C1 NCI, BETHESDA, MD 20892 USA. JAPAN NATL INST ENVIRONM STUDIES, IBARAKI, JAPAN. PACIFIC NW LAB, RICHLAND, WA 99352 USA. RP AKIBA, S (reprint author), RADIAT EFFECTS RES FDN, DEPT EPIDEMIOL, 5-2 HIJIYAMA PK, MINAMI KU, HIROSHIMA 732, JAPAN. FU NCI NIH HHS [N01-CP-71128] NR 25 TC 40 Z9 40 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD MAR 15 PY 1991 VL 67 IS 6 BP 1707 EP 1712 DI 10.1002/1097-0142(19910315)67:6<1707::AID-CNCR2820670638>3.0.CO;2-C PG 6 WC Oncology SC Oncology GA FC040 UT WOS:A1991FC04000037 PM 2001562 ER PT J AU BRODER, S AF BRODER, S TI THE HUMAN COSTS OF CANCER AND THE RESPONSE OF THE NATIONAL CANCER PROGRAM SO CANCER LA English DT Article; Proceedings Paper CT NATIONAL CONF ON CANCER AND THE CHANGING HEALTHCARE SYSTEM CY MAY 03-05, 1990 CL SAN FRANCISCO, CA SP AMER CANC SOC AB The three foundations of the National Cancer Program are basic research, clinical trials (in prevention and treatment), and cancer centers. These foundations have supported a great deal of progress against cancer over the past 20 years. Nevertheless, a number of challenges remain, and continued progress will depend on the speed with which research advances can be translated into practical realities. Poverty is a risk factor for cancer incidence and mortality. Thus, a lack of access to the technologies generated by the National Cancer Program can be a force for bringing about differential burdens of cancer in underserved populations. RP BRODER, S (reprint author), NCI,BLDG 31,ROOM 11A48,9000 ROCKVILLE PIKE,BETHESDA,MD 20892, USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD MAR 15 PY 1991 VL 67 IS 6 SU S BP 1716 EP 1717 PG 2 WC Oncology SC Oncology GA FC774 UT WOS:A1991FC77400002 PM 2001564 ER PT J AU COOK, JA IYPE, SN MITCHELL, JB AF COOK, JA IYPE, SN MITCHELL, JB TI DIFFERENTIAL SPECIFICITY OF MONOCHLOROBIMANE FOR ISOZYMES OF HUMAN AND RODENT GLUTATHIONE S-TRANSFERASES SO CANCER RESEARCH LA English DT Article ID CELLULAR GLUTATHIONE; TUMOR-CELLS; RAT-LIVER; ISOENZYMES; RESISTANCE; EXPRESSION; PURIFICATION; PROTEINS; INVITRO; HAMSTER AB Monochlorobimane (MCB) has been used as a glutathione (GSH) specific fluorescent probe capable of delineating GSH heterogeneity in cellular systems. Generally, low concentrations of MCB (< 50-mu-M) have been used to quantitatively label GSH in rodent cell lines. Incubation of the hamster cell lines, CHO AB1 and V79, with 10-mu-M MCB labeled 75 and 39% of the reduced GSH pool, respectively. In contrast, incubation of 7 different human cell lines with 10-mu-M MCB labeled less than 4% of the total reduced GSH pool. The human cell lines required 1000-mu-M MCB to label an average of 73% of the GSH pool (range, 60-88%). When using 1000-mu-M MCB to label GSH, flow cytometry results from 7 different cell lines (human and rodent) were in good agreement with high performance liquid chromatography and standard spectrophotometric analysis with regards to a rank ordering of the GSH content determined for each cell line. The human glutathione S-transferases B2B2, B1B2, psi, pi, and the rat transferases 1-2, 3-3, and 3-4 were isolated and purified for steady state kinetic analysis with MCB and GSH as the primary substrates. The human basic transferases, B1B2 and B2B2, had K(m) values for MCB of 354 and 283-mu-M and V(max) values of 33.3 and 34.6-mu-mol bimane-GSH/min/mg protein, respectively. The rat basic transferase 1-2 showed similar kinetic results with a K(m) of 199-mu-M and a V(max) of 35.5-mu-mol bimane-GSH/min/mg protein. The human neutral transferase (psi) had a K(m) for MCB of 204-mu-M with a V(max) of 6.5-mu-mol bimane-GSH/min/mg protein. In contrast, MCB has a high affinity for the rat neutral transferase with a K(m) of 2.6-mu-M and a V(max) of 35.1-mu-mol bimane-GSH/min/mg protein. The human acidic transferase (pi), the predominate transferase found in most human tumor cell lines, has a K(m) of 264-mu-M for MCB and a V(max) of 1.99-mu-mol bimane-GSH/min/mg protein. The k(cat)/K(m) values indicated that MCB is an excellent substrate for the rat neutral transferases while the human pi glutathione S-transferase showed the least reactivity. Collectively the data indicate that MCB fails to label GSH at lower concentrations (< 50-mu-M) in human cell lines because of the reduced affinity of MCB for the human transferases and possibly also due to differences in glutathione S-transferase isozyme expression between rodent and human cell lines. RP COOK, JA (reprint author), NCI,RADIAT ONCOL BRANCH,BLDG 10,ROOM B3 B69,BETHESDA,MD 20892, USA. NR 34 TC 65 Z9 65 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 0008-5472 J9 CANCER RES JI Cancer Res. PD MAR 15 PY 1991 VL 51 IS 6 BP 1606 EP 1612 PG 7 WC Oncology SC Oncology GA FB576 UT WOS:A1991FB57600006 PM 1998951 ER PT J AU KAPLAN, O JAROSZEWSKI, JW CLARKE, R FAIRCHILD, CR SCHOENLEIN, P GOLDENBERG, S GOTTESMAN, MM COHEN, JS AF KAPLAN, O JAROSZEWSKI, JW CLARKE, R FAIRCHILD, CR SCHOENLEIN, P GOLDENBERG, S GOTTESMAN, MM COHEN, JS TI THE MULTIDRUG RESISTANCE PHENOTYPE - P-31 NUCLEAR-MAGNETIC-RESONANCE CHARACTERIZATION AND 2-DEOXYGLUCOSE TOXICITY SO CANCER RESEARCH LA English DT Article ID BREAST CANCER-CELLS; SPECTROSCOPY; ADRIAMYCIN; METABOLISM; EXPRESSION; CARCINOMA AB In order to identify changes in P-31 nuclear magnetic resonance (NMR) spectra associated with multiple drug resistance (MDR), a number of wild type and drug-resistant cancer cell lines were studied. The resistant cells included cells selected with various drugs, mainly Adriamycin, as well as cells transfected with the human multidrug resistance gene (MDRI gene), which encodes P-glycoprotein. In most cases, P-31 NMR spectra were significantly different from those of parental, drug-sensitive lines. The spectra of resistant cells generally indicated increased levels of ATP and phosphocreatine in the cytoplasm. These changes are compatible with the increased glucose utilization rate previously described for resistant cells. Major changes were also observed in the levels of glycerophosphocholine and glycerophosphoethanolamine. Changes in cellular metabolism reflected by P-31 NMR spectra depend on the drug used to select the cells for MDR. The direction of these changes was not consistent for all cell lines studied and could not be directly attributed to expression of P-glycoprotein, suggesting that the changes may be related to alterations in metabolism and membrane function associated with other mechanisms of MDR. The results demonstrate the suitability of P-31 NMR for studies of biochemical changes associated with MDR. The toxicity of 2-deoxyglucose, a glucose antimetabolite, was investigated in addition to the NMR studies and was found to be consistently higher in multidrug-resistant cells than in the parental drug-sensitive lines. For MCF-7 breast cancer cells, where several sublines with different levels of resistance were available, the toxicity was highest for the most resistant lines. C1 NCI,CELL BIOL LAB,BETHESDA,MD 20892. GEORGETOWN UNIV,MED CTR,VINCENT T LOMBARDI CANC RES CTR,WASHINGTON,DC 20007. ROYAL DANISH SCH PHARM,DEPT ORGAN CHEM,DK-2100 COPENHAGEN,DENMARK. ROYAL DANISH SCH PHARM,PHARMABIOTEC RES CTR,DK-2100 COPENHAGEN,DENMARK. RP KAPLAN, O (reprint author), NCI,MED BRANCH,BETHESDA,MD 20892, USA. RI Clarke, Robert/A-6485-2008 OI Clarke, Robert/0000-0002-9278-0854 NR 27 TC 55 Z9 55 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 0008-5472 J9 CANCER RES JI Cancer Res. PD MAR 15 PY 1991 VL 51 IS 6 BP 1638 EP 1644 PG 7 WC Oncology SC Oncology GA FB576 UT WOS:A1991FB57600011 PM 1998955 ER PT J AU BRENNAN, J OCONNOR, T MAKUCH, RW SIMMONS, AM RUSSELL, E LINNOILA, RI PHELPS, RM GAZDAR, AF IHDE, DC JOHNSON, BE AF BRENNAN, J OCONNOR, T MAKUCH, RW SIMMONS, AM RUSSELL, E LINNOILA, RI PHELPS, RM GAZDAR, AF IHDE, DC JOHNSON, BE TI MYC FAMILY DNA AMPLIFICATION IN 107 TUMORS AND TUMOR-CELL LINES FROM PATIENTS WITH SMALL-CELL LUNG-CANCER TREATED WITH DIFFERENT COMBINATION CHEMOTHERAPY REGIMENS SO CANCER RESEARCH LA English DT Article ID C-MYC; GENE AMPLIFICATION; N-MYC; BRONCHOGENIC-CARCINOMA; EXPRESSION; ONCOGENE; PROTOONCOGENES; RADIATION; THERAPY AB We studied 107 specimens (38 tumors and 69 tumor cell lines) from 90 patients with small cell lung cancer to determine the characteristics and clinical situations of patients from whom tumor cell lines could be established and the myc family DNA copy number. The proportion of extensive stage small cell lung cancer patients from whom a tumor cell line could be established prior too the initiation of theraphy increased during the 10 years of the study (P < 0.001). Amplification of one of the myc family genes occurred in 3 of 40 (8%) of the untreated patient specimens compared to 19 of 67 (28%) of the treated patient specimens (P = 0.01). The myc family DNA amplification occurred in 17 of 54 (31%) of the specimens from patients treated with cyclophosphamide-based combinations and 2 of 13 (15%) of the specimens from patients treated with etoposide/cisplatin (P = 0.25). Both tumors and tumor cell lines were obtained from 17 patients with small cell lung cancer and the myc family DNA copy number was similar in 16 of the 17 patients. We conclude that: (a) myc family DNA amplification occurs more commonly in specimens from treated than untreated patients; (b) there are no prominent differences in the frequency of amplification following treatment with different chemotherapy regimens; and (c) myc family DNA amplification is similar in tumors and tumor cell lines from the same patients. C1 USN,NCI,NATL NAVAL MED CTR,NAVY MED ONCOL BRANCH,BLDG 8,ROOM 5101,BETHESDA,MD 20889. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20899. YALE UNIV,DIV BIOSTAT,NEW HAVEN,CT 06510. NR 24 TC 91 Z9 94 U1 1 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 0008-5472 J9 CANCER RES JI Cancer Res. PD MAR 15 PY 1991 VL 51 IS 6 BP 1708 EP 1712 PG 5 WC Oncology SC Oncology GA FB576 UT WOS:A1991FB57600022 PM 1847842 ER PT J AU ABRAHAM, VS SACHS, DH SYKES, M AF ABRAHAM, VS SACHS, DH SYKES, M TI THE MECHANISM OF GVHD PROTECTION BY IL-2 SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,IMMUNOL BRANCH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A972 EP A972 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000321 ER PT J AU AHMED, SA KAYASTHA, AM MILES, EW AF AHMED, SA KAYASTHA, AM MILES, EW TI THE BETA-SUBUNIT OF TRYPTOPHAN SYNTHASE FROM SALMONELLA-TYPHIMURIUM - INACTIVATION OF PUTATIVE ACTIVE-SITE AND TUNNEL MUTANTS BY BETA-CL-L-ALANINE SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIH,BETHESDA,MD 20892. NR 1 TC 2 Z9 2 U1 0 U2 4 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1149 EP A1149 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001337 ER PT J AU AIDA, K NEGISHI, M AF AIDA, K NEGISHI, M TI POSTTRANSCRIPTIONAL REGULATION OF COUMARIN 7-HYDROXYLASE (P450COH) INDUCTION BY XENOBIOTICS IN MOUSE-LIVER - MESSENGER-RNA STABILIZATION BY PYRAZOLE SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIEHS,PHARMACOGENET SECT,REPROD & DEV TOXICOL LAB,RES TRIANGLE PK,NC 27709. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1165 EP A1165 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001433 ER PT J AU ALLISON, KC PIERCE, R STROBER, W HARRIMAN, GR AF ALLISON, KC PIERCE, R STROBER, W HARRIMAN, GR TI EXPRESSION OF IL-5 RECEPTORS AND RESPONSIVENESS TO IL-5 IN THE IMMUNODEFICIENT MOUSE STRAIN DBA/2HA SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAID,LCI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1001 EP A1001 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000493 ER PT J AU ASHER, AL MULE, JJ KASID, A RESTIFO, NP SALO, JC JAFFE, G FENDLY, B KRIEGLER, M ROSENBERG, SA AF ASHER, AL MULE, JJ KASID, A RESTIFO, NP SALO, JC JAFFE, G FENDLY, B KRIEGLER, M ROSENBERG, SA TI MURINE TUMOR-CELLS TRANSDUCED WITH THE GENE FOR TNF-ALPHA - EVIDENCE FOR PARACRINE IMMUNE EFFECTS OF TNF AGAINST TUMORS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,BETHESDA,MD 20892. GENENTECH INC,SAN FRANCISCO,CA 94080. CETUS CORP,EMERYVILLE,CA 94608. RI Restifo, Nicholas/A-5713-2008 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A964 EP A964 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000280 ER PT J AU ATKINSON, TP RODRIGUEZ, JL HULTSCH, T BARDWELL, S KALINER, M HOHMAN, RJ AF ATKINSON, TP RODRIGUEZ, JL HULTSCH, T BARDWELL, S KALINER, M HOHMAN, RJ TI DIISOPROPYLFLUOROPHOSPHATE INACTIVATES PHOSPHOLIPASE-C ACTIVITY IN CELL-FREE-EXTRACTS FROM RAT BASOPHILIC LEUKEMIA-CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1008 EP A1008 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000530 ER PT J AU AVIGAN, J MURTAGH, JJ STEVENS, LA ANGUS, CW MOSS, J VAUGHAN, M AF AVIGAN, J MURTAGH, JJ STEVENS, LA ANGUS, CW MOSS, J VAUGHAN, M TI REQUIREMENTS FOR PERTUSSIS TOXIN-CATALYZED ADP-RIBOSYLATION OF GUANINE NUCLEOTIDE-BINDING PROTEINS - EFFECTS OF INVITRO MUTAGENESIS AT THE CARBOXYTERMINUS OF G0-ALPHA SO FASEB JOURNAL LA English DT Meeting Abstract ID DNA C1 NHLBI,CELLULAR METAB LAB,BETHESDA,MD 20892. NR 2 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1067 EP A1067 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000870 ER PT J AU AXLEY, MJ STADTMAN, TC AF AXLEY, MJ STADTMAN, TC TI EFFECTS ON PROPERTIES AND ACTIVITIES OF FORMATE DEHYDROGENASE-H WHEN SULFUR REPLACES SELENIUM SO FASEB JOURNAL LA English DT Meeting Abstract C1 NHLBI,BIOCHEM LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1151 EP A1151 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001352 ER PT J AU BARNES, MI MITCHELL, CL AF BARNES, MI MITCHELL, CL TI BILATERAL COLCHICINE LESIONS OF DORSAL, VENTRAL, OR DORSAL AND VENTRAL DENTATE GYRUS DECREASE SEIZURE THRESHOLDS AND WET DOG SHAKES IN RATS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIEHS,LMIN,RES TRIANGLE PK,NC 27709. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1211 EP A1211 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001703 ER PT J AU BARRETT, JC FUTREAL, PA ANNAB, LA BIVINS, H RICHTER, H OSHIMURA, M AF BARRETT, JC FUTREAL, PA ANNAB, LA BIVINS, H RICHTER, H OSHIMURA, M TI CELLULAR SENESCENCE AND CANCER SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIEHS,MOLEC CARCINOGENESIS LAB,RES TRIANGLE PK,NC 27709. TOTTORI UNIV,YONAGO,TOTTORI 683,JAPAN. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1441 EP A1441 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55003037 ER PT J AU BENHAMOU, M STEPHAN, V GUTKIND, SJ ROBBINS, KC SIRAGANIAN, RP AF BENHAMOU, M STEPHAN, V GUTKIND, SJ ROBBINS, KC SIRAGANIAN, RP TI PROTEIN TYROSINE PHOSPHORYLATION IN THE DEGRANULATION STEP OF RBL-2H3 CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIDR,BETHESDA,MD 20892. NR 1 TC 4 Z9 4 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1007 EP A1007 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000524 ER PT J AU BHARUCHA, VA PEDEN, KWC NARAYANAN, V TENNEKOON, GI AF BHARUCHA, VA PEDEN, KWC NARAYANAN, V TENNEKOON, GI TI ONCOGENE-SPECIFIC DOWN-REGULATION OF MOUSE MYELIN P2 EXPRESSION SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV MICHIGAN,DEPT PEDIAT,ANN ARBOR,MI 48109. UNIV MICHIGAN,DEPT NEUROL,ANN ARBOR,MI 48109. NIAID,BETHESDA,MD 20892. UNIV PITTSBURGH,DEPT PEDIAT,PITTSBURGH,PA 15261. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1170 EP A1170 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001464 ER PT J AU BHATHENA, SJ KIM, YC LAW, JS BERLIN, E JUDD, JT REICHMAN, ME TAYLOR, PR SCHATZKIN, A AF BHATHENA, SJ KIM, YC LAW, JS BERLIN, E JUDD, JT REICHMAN, ME TAYLOR, PR SCHATZKIN, A TI EFFECT OF MODERATE ALCOHOL CONSUMMATION ON PLASMA OPIATE LEVELS IN PREMENOPAUSAL WOMEN SO FASEB JOURNAL LA English DT Meeting Abstract C1 USDA,BHNRC,CNL,BELTSVILLE,MD 20705. USDA,BHNRC,LNL,BELTSVILLE,MD 20705. NCI,DCPC,CPSB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A936 EP A936 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000122 ER PT J AU BISGAARD, HC NAKATSUKASA, H EVARTS, RP TON, PT THORGEIRSSON, SS AF BISGAARD, HC NAKATSUKASA, H EVARTS, RP TON, PT THORGEIRSSON, SS TI INVITRO AND INVIVO EXPRESSION OF CYTOKERATIN-14 IN EPITHELIAL-CELLS FROM RAT-LIVER AND PANCREAS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,EXPTL CARCINOGENESIS LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1249 EP A1249 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001924 ER PT J AU BLOCK, G MANGELS, AR LEVANDER, OA PATTERSON, BH CAMPBELL, W NORKUS, E TAYLOR, PR AF BLOCK, G MANGELS, AR LEVANDER, OA PATTERSON, BH CAMPBELL, W NORKUS, E TAYLOR, PR TI PLASMA REDUCED AND OXIDIZED ASCORBATE ATTAINED ON VARIOUS LEVELS OF DIETARY-INTAKE SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,BETHESDA,MD 20892. USDA,BELTSVILLE,MD 20705. RI Block, Gladys/E-3304-2010 NR 0 TC 3 Z9 3 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1444 EP A1444 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55003052 ER PT J AU BRAUNELWERT, L MULLIN, GE JAMES, SP AF BRAUNELWERT, L MULLIN, GE JAMES, SP TI LYMPHOKINE MESSENGER-RNA EXPRESSION IS DIFFERENT IN THE NORMAL INTESTINAL-MUCOSA AND PBL SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAID,MUCOSAL IMMUNITY SECT,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A982 EP A982 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000379 ER PT J AU BURNETTE, B KAHN, R GLOVER, C FELSTED, R AF BURNETTE, B KAHN, R GLOVER, C FELSTED, R TI PURIFICATION, INVITRO MYRISTOYLATION AND CHARACTERIZATION OF BACTERIALLY EXPRESSED HIV-1 P17GAG PROTEIN SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,DCT,DTP,BIOL CHEM LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1266 EP A1266 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002025 ER PT J AU CARR, DJJ DECOSTA, BR RICE, KC BLALOCK, JE AF CARR, DJJ DECOSTA, BR RICE, KC BLALOCK, JE TI [H-3] (+)-PENTAZOCINE SELECTIVE BINDING-SITES ON CELLS OF THE IMMUNE-SYSTEM SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV ALABAMA,DEPT PHYSIOL & BIOPHYS,BIRMINGHAM,AL 35294. NIDDK,MED CHEM LAB,BETHESDA,MD. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1384 EP A1384 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002710 ER PT J AU CATANIA, A SUFFREDINI, AF LIPTON, JM AF CATANIA, A SUFFREDINI, AF LIPTON, JM TI ALPHA-MSH RESPONSE TO ENDOTOXIN IN NORMAL HUMAN-SUBJECTS SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV TEXAS,HLTH SCI CTR,SW MED SCH,DEPT PHYSIOL,DALLAS,TX 75235. NIH,BETHESDA,MD 20892. MED CLIN 1,I-20122 MILAN,ITALY. NR 0 TC 6 Z9 6 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1392 EP A1392 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002757 ER PT J AU CHOU, CL KNEPPER, M AF CHOU, CL KNEPPER, M TI PERMEABILITY PROPERTIES OF CHINCHILLA LONG LOOPS OF HENLE SO FASEB JOURNAL LA English DT Meeting Abstract C1 NHLBI,BETHESDA,MD 20892. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1408 EP A1408 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002846 ER PT J AU CLIMENT, I SJOBERG, BM HUANG, CY AF CLIMENT, I SJOBERG, BM HUANG, CY TI CARBOXYL TERMINAL PEPTIDES AS PROBES FOR ESCHERICHIA-COLI RIBONUCLEOTIDE REDUCTASE SUBUNIT INTERACTION SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV STOCKHOLM,S-10691 STOCKHOLM,SWEDEN. NHLBI,BIOCHEM LAB,BETHESDA,MD 20892. NR 0 TC 3 Z9 3 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1151 EP A1151 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001350 ER PT J AU COOK, JC CHOCK, PB AF COOK, JC CHOCK, PB TI IMMUNOCYTOCHEMICAL STAINING OF HELA-CELLS DURING MITOSIS SUGGESTS THAT UBIQUITIN ACTIVATING ENZYME ASSOCIATES WITH CHROMATIN AND MICROTUBULE ORGANIZING CENTERS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NHLBI,BIOCHEM LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1178 EP A1178 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001513 ER PT J AU COSTA, JJ BURD, PR METCALFE, DD AF COSTA, JJ BURD, PR METCALFE, DD TI CYTOKINE MESSENGER-RNA INDUCTION BY NON-FC-EPSILON-RI-MEDIATED STIMULI IN MURINE MAST-CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAID,BETHESDA,MD 20892. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1084 EP A1084 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000970 ER PT J AU COX, GW CHATTOPADHYAY, U OPPENHEIM, JJ VARESIO, L AF COX, GW CHATTOPADHYAY, U OPPENHEIM, JJ VARESIO, L TI INTERLEUKIN-4 SELECTIVELY INHIBITS INTERLEUKIN-2-INDUCED MURINE MACROPHAGE CELL-LINE TUMORICIDAL ACTIVITY SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,FREDERICK CANC RES FACIL,BRMP,MOLEC IMMUNOREGULAT LAB,FREDERICK,MD 21701. RI varesio, luigi/J-8261-2016 OI varesio, luigi/0000-0001-5659-2218 NR 1 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1350 EP A1350 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002507 ER PT J AU DANISHEFSKY, AT RUBIN, JR BURTON, LE AF DANISHEFSKY, AT RUBIN, JR BURTON, LE TI X-RAY CRYSTALLOGRAPHIC STUDIES OF HUMAN RECOMBINANT TRANSFORMING GROWTH FACTOR-ALPHA SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,FREDERICK CANC RES FACIL,FREDERICK,MD 21701. GENENTECH INC,SAN FRANCISCO,CA 94080. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1185 EP A1185 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001555 ER PT J AU DEERAUSQUIN, GA BROOKER, G HANBAUER, I AF DEERAUSQUIN, GA BROOKER, G HANBAUER, I TI THE EFFECT OF N-TYPE CA2+ CHANNEL BLOCKERS ON [CA2+]I DYNAMICS IN SOMA AND DENDRITES OF DOPAMINERGIC-NEURONS SO FASEB JOURNAL LA English DT Meeting Abstract C1 GEORGETOWN UNIV,DEPT BIOCHEM,FIDIA GEORGETOWN INST NEUROSCI,WASHINGTON,DC 20007. NHLBI,CHEM PHARMACOL LAB,BETHESDA,MD 20892. RI de Erausquin, Gabriel/G-5840-2010 OI de Erausquin, Gabriel/0000-0001-6423-4461 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1102 EP A1102 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001072 ER PT J AU DOSREIS, GA SHEVACH, EM AF DOSREIS, GA SHEVACH, EM TI A MURINE VERY EARLY ACTIVATION (VEA) ANTIGEN FUNCTIONS AS A RECEPTOR FOR ACCESSORY CELL(AC)-DERIVED COSTIMULATORY ACTIVITY SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAID,LI,BETHESDA,MD 20892. NR 1 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A991 EP A991 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000433 ER PT J AU EHRHARDT, RO STROBER, W HARRIMAN, GR AF EHRHARDT, RO STROBER, W HARRIMAN, GR TI PLEIOTROPIC EFFECTS OF TGF-BETA ON IGA EXPRESSION IN DIFFERENT B-CELL ACTIVATION SYSTEMS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAID,MUCOSAL IMMUN SECT,LCI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1001 EP A1001 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000490 ER PT J AU ESPINOZADELGADO, I LONGO, DL GUSELLA, GL VARESIO, L AF ESPINOZADELGADO, I LONGO, DL GUSELLA, GL VARESIO, L TI INTERFERON-GAMMA AND INTERLEUKIN-2 DIFFERENTIALLY REGULATE INTERLEUKIN-2 RECEPTOR GENE-EXPRESSION ON HUMAN MONOCYTES SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,FREDERICK CANC RES FACIL,BIOL RESPONSE MODIFIERS PROGRAM,FREDERICK,MD 21701. RI varesio, luigi/J-8261-2016 OI varesio, luigi/0000-0001-5659-2218 NR 1 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1350 EP A1350 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002509 ER PT J AU EVARTS, RP NAKATSUKASA, H MARSDEN, ER THORGEIRSSON, SS AF EVARTS, RP NAKATSUKASA, H MARSDEN, ER THORGEIRSSON, SS TI EXPRESSION OF TGF-ALPHA IN PROLIFERATING HEPATOCYTES AND DURING HEPATIC DIFFERENTIATION SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,EXPTL CARCINOGENESIS LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1247 EP A1247 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001916 ER PT J AU FALETTO, MB LINKO, P GOLDSTEIN, JA AF FALETTO, MB LINKO, P GOLDSTEIN, JA TI A SINGLE AMINO-ACID SUBSTITUTION (SER180-]CYS) IS RESPONSIBLE FOR THE PHENOTYPIC VARIATION IN EXPRESSION OF CYTOCHROME-P-450G (2C13) SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIEHS,RES TRIANGLE PK,NC 27709. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1163 EP A1163 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001424 ER PT J AU FINE, JS KRUISBEEK, AM AF FINE, JS KRUISBEEK, AM TI DEVELOPMENTALLY REGULATED EXPRESSION AND FUNCTION OF CELL-ADHESION MOLECULES IN THE THYMUS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,BIOL RESPONSE MODIFIERS PROGRAM,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1456 EP A1456 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55003126 ER PT J AU FREY, J ANDERSON, S YOUNG, H ORTALDO, J AF FREY, J ANDERSON, S YOUNG, H ORTALDO, J TI ANALYSIS OF A POTENTIAL NK-TUMOR RECOGNITION TRIGGERING MOLECULE USING ANTIPEPTIDE ANTIBODIES SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,FREDERICK CANC RES FACIL,EXPTL IMMUNOL LAB,FREDERICK,MD 21701. NATL RES COUNCIL CANADA,BIOTECHNOL RES INST,MONTREAL,QUEBEC,CANADA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1338 EP A1338 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002440 ER PT J AU GAZZINELLI, RT HAKIM, F DENKERS, E HIENY, S SHEARER, G SHER, A AF GAZZINELLI, RT HAKIM, F DENKERS, E HIENY, S SHEARER, G SHER, A TI VACCINATED MICE DISPLAY CD8+ DEPENDENT IFN-GAMMA PRODUCTION AND CYTOLYTIC ACTIVITY AGAINST HOST-CELLS INFECTED WITH TOXOPLASMA-GONDII SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAID,BETHESDA,MD 20892. NCI,BETHESDA,MD 20892. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1338 EP A1338 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002438 ER PT J AU GIRI, JG NEWTON, RC LISCHWE, MA ULLRICH, S SAKAGUCHI, K APPELLA, E HORUK, R AF GIRI, JG NEWTON, RC LISCHWE, MA ULLRICH, S SAKAGUCHI, K APPELLA, E HORUK, R TI SOLUBLE IL-1 BINDING-PROTEIN FROM HUMAN B-CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 DUPONT CO,GLENOLDEN,PA 19036. NIH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1331 EP A1331 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002400 ER PT J AU GONGZAGA, HMS YAMADA, K ALI, H BEAVEN, MA AF GONGZAGA, HMS YAMADA, K ALI, H BEAVEN, MA TI THE ROLE OF PHOSPHOLIPASE-D IN EXOCYTOSIS IN ANTIGEN-STIMULATED RBL-2H3 CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NHLBI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1007 EP A1007 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000529 ER PT J AU GRAHAME, DA AF GRAHAME, DA TI CATALYSIS OF METHYL-GROUP TRANSFER FROM ACETYL COA TO TETRAHYDROSARCINAPTERIN BY A CARBON-MONOXIDE DEHYDROGENASE-CORRINOID ENZYME COMPLEX FROM METHANOSARCINA-BARKERI SO FASEB JOURNAL LA English DT Meeting Abstract C1 NHLBI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1202 EP A1202 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001650 ER PT J AU HAMAWY, MM OLIVER, C SIRAGANIAN, RP AF HAMAWY, MM OLIVER, C SIRAGANIAN, RP TI INHIBITION OF IGE BINDING TO RBL-2H3 CELLS BY A MONOCLONAL-ANTIBODY (MAB) TO A SURFACE PROTEIN OTHER THAN THE HIGH-AFFINITY IGE RECEPTOR (FC-EPSILON-RI) SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIDR,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1006 EP A1006 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000520 ER PT J AU HAMPTON, LL HUGGETT, AC ELLIS, PA FORD, CP THORGEIRSSON, SS AF HAMPTON, LL HUGGETT, AC ELLIS, PA FORD, CP THORGEIRSSON, SS TI ALTERED GENE-EXPRESSION AND INTERCELLULAR COMMUNICATION (IC) IN SPONTANEOUSLY TRANSFORMED RAT-LIVER EPITHELIAL (RLE) CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,EXPTL CARCINOGENESIS LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1248 EP A1248 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001921 ER PT J AU HARGROVE, ME LIANG, SM LIANG, CM TING, CC AF HARGROVE, ME LIANG, SM LIANG, CM TING, CC TI DICHOTOMY IN GLUTATHIONE (GSH) REGULATION OF LYMPHOCYTE-ACTIVATION SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,BETHESDA,MD 20892. US FDA,BETHESDA,MD 20014. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1342 EP A1342 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002464 ER PT J AU HEINEMAN, FW BALABAN, RS AF HEINEMAN, FW BALABAN, RS TI VARIATIONS IN MYOCARDIAL INTRACELLULAR PH IN RESPONSE TO ALTERED EXTRACELLULAR K+ SO FASEB JOURNAL LA English DT Meeting Abstract C1 NHLBI,CARDIAC ENERGET LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1427 EP A1427 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002956 ER PT J AU HOHMAN, RJ HULTSCH, T AF HOHMAN, RJ HULTSCH, T TI PURIFICATION OF CYCLOPHILIN, THE CYCLOSPORINE-A BINDING-PROTEIN, FROM RAT BASOPHILIC LEUKEMIA-CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1087 EP A1087 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000983 ER PT J AU HOLDEN, J MANGELS, AR BEECHER, G FORMAN, M LANZA, E AF HOLDEN, J MANGELS, AR BEECHER, G FORMAN, M LANZA, E TI THE CRITICAL-EVALUATION OF VALUES OF CAROTENOIDS FOR FOODS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,DCPC,ROCKVILLE,MD 20852. USDA ARS,BELTSVILLE AGR RES CTR,BELTSVILLE,MD 20705. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1323 EP A1323 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002353 ER PT J AU HORGAN, KJ LUCE, GEG TANAKA, Y SHAW, S AF HORGAN, KJ LUCE, GEG TANAKA, Y SHAW, S TI CD45RB ISOFORM EXPRESSION DISTINGUISHES 2 SUBSETS WITHIN HUMAN CD4+ MEMORY T-CELLS WHICH APPEAR TO BE SEQUENTIALLY RELATED SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,ENDOCRINOL IMMUNOL BRANCH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A962 EP A962 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000269 ER PT J AU HUH, JW RYU, JH SOHN, DH PARK, KS SONG, BJ AF HUH, JW RYU, JH SOHN, DH PARK, KS SONG, BJ TI RAPID PURIFICATION AND CHARACTERIZATION OF P68-PROTEIN FROM BOVINE HEART-MUSCLE SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAAA,METAB & MOLEC BIOL LAB,ROCKVILLE,MD 20852. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1233 EP A1233 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001833 ER PT J AU HUH, TL HUH, JW VEECH, RL SONG, BJ AF HUH, TL HUH, JW VEECH, RL SONG, BJ TI COORDINATE, PRETRANSLATIONAL EXPRESSION OF PYRUVATE-DEHYDROGENASE COMPLEX DURING ADIPOCYTE DIFFERENTIATION SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAAA,METAB & MOLEC BIOL LAB,ROCKVILLE,MD 20852. NR 1 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1200 EP A1200 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001639 ER PT J AU HULTSCH, T SCHREIBER, SL HOHMAN, RJ AF HULTSCH, T SCHREIBER, SL HOHMAN, RJ TI INHIBITION OF IGE RECEPTOR MEDIATED EXOCYTOSIS FROM RAT BASOPHILIC LEUKEMIA-CELLS BY FK-506 IS REVERSED BY RAPAMYCIN - EVIDENCE FOR COMMON SIGNALING PATHWAYS IN MAST-CELLS AND LYMPHOCYTES-T SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIH,BETHESDA,MD 20892. NR 1 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1008 EP A1008 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000532 ER PT J AU HUMMELL, DS KHAN, AS DOOLEY, JS LAWTON, AR AF HUMMELL, DS KHAN, AS DOOLEY, JS LAWTON, AR TI SUPPRESSION OF MULV AND IG HEAVY-CHAIN GENE-EXPRESSION IN LPS-STIMULATED B-CELLS BY ANTIBODIES TO IGM IS ASSOCIATED WITH NUCLEAR-PROTEIN BINDING TO AN HOMOLOGOUS DNA MOTIF SO FASEB JOURNAL LA English DT Meeting Abstract C1 VANDERBILT UNIV,NASHVILLE,TN 37232. NIAID,MOL MICRO LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1002 EP A1002 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000499 ER PT J AU HURSTING, S SWITZER, B FRENCH, J KARI, F AF HURSTING, S SWITZER, B FRENCH, J KARI, F TI GENDER INFLUENCE ON DIET-INDUCED MODULATION OF MONONUCLEAR CELL LEUKEMIA IN F344 RATS SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV N CAROLINA,DEPT NUTR,CHAPEL HILL,NC 27599. NIEHS,RTP,RES TRIANGLE PK,NC 27709. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A928 EP A928 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000075 ER PT J AU IWASAKI, M JUVONEN, R NEGISHI, M AF IWASAKI, M JUVONEN, R NEGISHI, M TI PROXIMITY OF AMINO ACID-209 TO THE 6TH LIGAND OF HEME IN MOUSE CYTOCHROME-P450S - SPECTROSCOPIC STUDY AND INVITRO MUTAGENESIS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIEHS,PHARMACOGENET SECT,REPROD & DEV TOXICOL LAB,RES TRIANGLE PK,NC 27709. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1165 EP A1165 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001435 ER PT J AU JONES, ML GRANDE, JP KILLEN, PD YOSHIMURA, T WARD, PA WARREN, JS AF JONES, ML GRANDE, JP KILLEN, PD YOSHIMURA, T WARD, PA WARREN, JS TI REGULATION OF MONOCYTE CHEMOATTRACTANT PROTEIN (MCP-1) MESSENGER-RNA EXPRESSION IN RAT MESANGIAL CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV MICHIGAN,SCH MED,DEPT PATHOL,ANN ARBOR,MI 48109. NCI,IMMUNOBIOL LAB,FREDERICK,MD 21701. NR 0 TC 1 Z9 1 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A975 EP A975 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000341 ER PT J AU JUSTEMENT, JS POLI, G KINTER, A BRESSLER, P KEHRL, JH FAUCI, AS AF JUSTEMENT, JS POLI, G KINTER, A BRESSLER, P KEHRL, JH FAUCI, AS TI DICHOTOMOUS EFFECTS OF TRANSFORMING GROWTH-FACTOR-BETA (TGF-BETA) ON HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) EXPRESSION IN MONONUCLEAR PHAGOCYTES (MP) SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAID,LIR,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1265 EP A1265 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002020 ER PT J AU KARI, F WEAVER, R HARRIS, M DAVIS, B SCHWETZ, B AF KARI, F WEAVER, R HARRIS, M DAVIS, B SCHWETZ, B TI STUDIES OF NITROFURANTOIN-INDUCED GROWTH IMPAIRMENT IN SUCKLING RAT PUPS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIEHS,RTP,RES TRIANGLE PK,NC 27709. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A933 EP A933 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000104 ER PT J AU KAWAKAMI, Y ZAKUT, R TOPALIAN, S ROSENBERG, SA AF KAWAKAMI, Y ZAKUT, R TOPALIAN, S ROSENBERG, SA TI TRANSFECTION OF THE HLA-A2.1 GENE INTO NON-HLA-A2 ALLOGENEIC MELANOMAS ALLOWS THE RECOGNITION OF SHARED MELANOMA ANTIGEN BY HLA-A2 RESTRICTED MELANOMA SPECIFIC CYTOTOXIC T-CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,SURG BRANCH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1333 EP A1333 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002409 ER PT J AU KENNEDY, ICS JUNE, C OSHEA, JJ AF KENNEDY, ICS JUNE, C OSHEA, JJ TI EPIDERMAL GROWTH-FACTOR RECEPTOR DEPENDENT ZETA-CHAIN TYROSINE PHOSPHORYLATION IN A MURINE T-CELL HYBRIDOMA EXPRESSING THIS RECEPTOR SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,FCRDC,BRMP,FREDERICK,MD 21702. USN,MED BRANCH,BETHESDA,MD 20892. USN,MED RES INST,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A992 EP A992 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000441 ER PT J AU KIM, Y BUCHHOLZ, M NORDIN, A AF KIM, Y BUCHHOLZ, M NORDIN, A TI THE IL-2 REGULATION OF TYROSINE PHOSPHORYLATION OF CELLULAR PROTEINS OF LYMPHOCYTE-T SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIA,BALTIMORE,MD 21224. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1378 EP A1378 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002674 ER PT J AU KIM, YA SCOTT, RF VEECH, RL AF KIM, YA SCOTT, RF VEECH, RL TI INTRACELLULAR INORGANIC-ION CONTENT AND DELTA-G ATP HYDROLYSIS IN LYMPHOBLASTS FROM NORMAL SUBJECTS, HETERZYGOTES AND HOMOZYGOTES FOR CYSTIC-FIBROSIS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAAA,LMMB,ROCKVILLE,MD 20852. NR 1 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A933 EP A933 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000103 ER PT J AU KINTER, AL KALEBIC, T POLI, G FAUCI, AS AF KINTER, AL KALEBIC, T POLI, G FAUCI, AS TI SUPPRESSION OF CYTOKINE-INDUCED HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) EXPRESSION BY N-ACETYL-CYSTEIN (NAC), GLUTATHIONE (GSH) AND GLUTATHIONE-MONOESTER (GSE) SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAID,LIR,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1265 EP A1265 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002018 ER PT J AU KNECHT, KT THURMAN, RG MASON, RP AF KNECHT, KT THURMAN, RG MASON, RP TI FREE-RADICAL METABOLISM OF ETHANOL BY DEERMOUSE MICROSOMES SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV N CAROLINA,CURRICULUM TOXICOL,CHAPEL HILL,NC 27514. UNIV N CAROLINA,DEPT PHARMACOL,CHAPEL HILL,NC 27514. NIEHS,RES TRIANGLE PK,NC 27709. NR 1 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1209 EP A1209 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001693 ER PT J AU KRAMLIK, SK HETHERINGTON, M ALTEMUS, M CHROUSOS, G CASTONGUAY, TW AF KRAMLIK, SK HETHERINGTON, M ALTEMUS, M CHROUSOS, G CASTONGUAY, TW TI HYPERCORTISOLISM ASSOCIATED WITH INCREASED FAT INTAKE SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV MARYLAND,COLLEGE PK,MD 20742. NIMH,BETHESDA,MD 20892. NICHHD,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A960 EP A960 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000255 ER PT J AU KULAGA, H COGGIANO, M ADAMS, T SWEETNAM, PM AF KULAGA, H COGGIANO, M ADAMS, T SWEETNAM, PM TI HIV-1 INFECTION OF HCN-1A A HUMAN CORTICAL NEURONAL CELL-LINE SO FASEB JOURNAL LA English DT Meeting Abstract C1 NOVASCREEN,WASHINGTON,DC 20032. NIMH,BETHESDA,MD 20892. NPB,WASHINGTON,DC. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1265 EP A1265 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002021 ER PT J AU LAW, JS BHATHENA, SJ KIM, YC BERLIN, E JUDD, JT REICHMAN, ME TAYLOR, PR SCHATZKIN, A AF LAW, JS BHATHENA, SJ KIM, YC BERLIN, E JUDD, JT REICHMAN, ME TAYLOR, PR SCHATZKIN, A TI EFFECT OF ALCOHOL-CONSUMPTION ON HORMONES INVOLVED IN CARBOHYDRATE AND LIPID-METABOLISM IN PREMENOPAUSAL WOMEN SO FASEB JOURNAL LA English DT Meeting Abstract C1 USDA,BHNRC,CNL,BELTSVILLE,MD 20705. USDA,BHNRC,LNL,BELTSVILLE,MD 20705. NCI,DCPC,CPSB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A936 EP A936 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000119 ER PT J AU LITTLE, J MOND, J KLEIN, A WITHERSPOON, K ABRAMS, J ASOFSKY, R AF LITTLE, J MOND, J KLEIN, A WITHERSPOON, K ABRAMS, J ASOFSKY, R TI INDUCTION OF CYTOKINE SECRETION IN MITOGEN AND ANTIIMMUNOGLOBULIN TREATED MURINE LYMPHOCYTES-B SO FASEB JOURNAL LA English DT Meeting Abstract C1 DNAX RES INST MOLEC & CELLULAR BIOL INC,PALO ALTO,CA. NIAID,IMMUNOL LAB,BETHESDA,MD 20892. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. NR 1 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1000 EP A1000 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000486 ER PT J AU LIVINGSTON, PG KURANE, I LAI, CJ MEN, R ENNIS, FA AF LIVINGSTON, PG KURANE, I LAI, CJ MEN, R ENNIS, FA TI DENGUE VIRUS-SPECIFIC, SEROTYPE CROSS-REACTIVE, CD8+, HUMAN CTL RECOGNIZE EPITOPES ON THE NS3 PROTEIN SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV MASSACHUSETTS,MED,WORCESTER,MA 01605. NIAID,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1375 EP A1375 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002655 ER PT J AU LONDON, RE MURPHY, E STEENBERGEN, C GABEL, SA LEVY, LA PERLMAN, ME AF LONDON, RE MURPHY, E STEENBERGEN, C GABEL, SA LEVY, LA PERLMAN, ME TI THE ROLE OF DIVALENT METAL-IONS AS MEDIATORS OF CELL INJURY - F-19 NMR-STUDIES OF THE PERFUSED RAT-HEART SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIEHS,MOLEC BIOPHYS LAB,RES TRIANGLE PK,NC 27709. NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1065 EP A1065 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000863 ER PT J AU LONGO, DL BENNETT, M HARRISON, CL KELLER, JR KUMAR, V YOUNG, H MURPHY, WJ AF LONGO, DL BENNETT, M HARRISON, CL KELLER, JR KUMAR, V YOUNG, H MURPHY, WJ TI IL-2 ACTIVATED NK CELLS SUPPORT HEMATOPOIESIS INVITRO AND PROMOTE ALLOGENEIC BONE-MARROW (BMC) ENGRAFTMENT INVIVO SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,FREDERICK CANC RES FACIL,BRMP,FREDERICK,MD 21701. NCI,FREDERICK CANC RES FACIL,PRI DYNCORP,FREDERICK,MD 21701. UNIV TEXAS,HLTH SCI CTR,SW MED SCH,DEPT PATHOL,DALLAS,TX 75235. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A973 EP A973 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000327 ER PT J AU LYCKE, N HOLMGREN, J SEVERINSON, E STROBER, W AF LYCKE, N HOLMGREN, J SEVERINSON, E STROBER, W TI CHOLERA-TOXIN ACTS SYNERGISTICALLY WITH LYMPHOKINES TO PROMOTE B-CELL ISOTYPE SWITCH DIFFERENTIATION SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAID,MUCOSAL IMMUN SECT,LCL,BETHESDA,MD 20892. UNIV STOCKHOLM,DEPT IMMUNOL,S-10691 STOCKHOLM,SWEDEN. GOTHENBURG UNIV,DEPT MED MICROBIOL & IMMUNOL,S-41124 GOTHENBURG,SWEDEN. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1003 EP A1003 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000506 ER PT J AU MAI, UEH WAHL, SM SMITH, PD AF MAI, UEH WAHL, SM SMITH, PD TI MACROPHAGES ISOLATED FROM HUMAN INTESTINAL-MUCOSA PRESENT ANTIGENS TO PERIPHERAL-BLOOD AND LAMINA PROPRIA T-CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIDR,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A968 EP A968 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000300 ER PT J AU MANGELS, AR BLOCK, G LEVANDER, OA TAYLOR, PR MORRIS, VC PATTERSON, BH AF MANGELS, AR BLOCK, G LEVANDER, OA TAYLOR, PR MORRIS, VC PATTERSON, BH TI DIFFERENCES IN PLASMA BETA-CAROTENE (P-BC) MAINTAINED DESPITE SIMILAR DIETARY BETA-CAROTENE SO FASEB JOURNAL LA English DT Meeting Abstract C1 USDA,HUMAN NUTR RES CTR,BELTSVILLE,MD 20705. NCI,BETHESDA,MD 20892. RI Block, Gladys/E-3304-2010 NR 0 TC 3 Z9 3 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1322 EP A1322 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002347 ER PT J AU MARTIN, G BALABAN, RS AF MARTIN, G BALABAN, RS TI EFFECT OF ISCHEMIA AND REPERFUSION ON P-31 NMR DETECTED RENAL OSMOLYTES SO FASEB JOURNAL LA English DT Meeting Abstract C1 NHLBI,CARDIAC ENERGET LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1408 EP A1408 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002849 ER PT J AU MUEGGE, K VILA, M MUSSO, T HERRLICH, P DURUM, SK AF MUEGGE, K VILA, M MUSSO, T HERRLICH, P DURUM, SK TI IL-1 ACTIVATION OF THE JUN GENE SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,BRMP,PRI,LMI,FREDERICK,MD 21701. KERNFORSCHUNGSZENTRUM KARLSRUHE GMBH,W-7500 KARLSRUHE 1,GERMANY. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1331 EP A1331 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002398 ER PT J AU MURPHY, P MCDERMOTT, D TIFFANY, HL AF MURPHY, P MCDERMOTT, D TIFFANY, HL TI CHARACTERIZATION OF 2 MEMBERS OF A HUMAN CHEMOTACTIC RECEPTOR GENE FAMILY SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIH,BETHESDA,MD 20892. NR 0 TC 2 Z9 2 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1352 EP A1352 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002519 ER PT J AU NAKATSUKASA, H EVARTS, RP SILVERMAN, JA MARSDEN, E THORGEIRSSON, SS AF NAKATSUKASA, H EVARTS, RP SILVERMAN, JA MARSDEN, E THORGEIRSSON, SS TI EXPRESSION OF MULTIDRUG-RESISTANCE (MDR) AND GLUTATHIONE-TRANSFERASE-P (GST-P) GENES IN RAT HEPATOCARCINOGENESIS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,EXPTL CARCINOGENESIS LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1247 EP A1247 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001917 ER PT J AU OKAJIMA, M BOHJANEN, P BONVINI, E CHUSED, T DEBELL, K ISHIDA, Y HODES, R AF OKAJIMA, M BOHJANEN, P BONVINI, E CHUSED, T DEBELL, K ISHIDA, Y HODES, R TI THE EFFECT OF PRIOR STIMULATION OF A MURINE T-CELL CLONE ON THE SUBSEQUENT INTRACELLULAR MEDIATOR RESPONSE TO TCR-SIGNALING SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAID,IMMUNOL LAB,BETHESDA,MD 20892. NCI,EXPTL IMMUNOL BRANCH,BETHESDA,MD 20892. US FDA,DIV BLOOD & BLOOD PROD,BETHESDA,MD 20205. RI Bohjanen, Paul/B-2329-2015 OI Bohjanen, Paul/0000-0002-2772-3597 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1456 EP A1456 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55003122 ER PT J AU OSHEA, JJ JUNE, C MERCEP, M KENNEDY, ICS BAILEY, TL NIKLINSKA, B ASHWELL, JD AF OSHEA, JJ JUNE, C MERCEP, M KENNEDY, ICS BAILEY, TL NIKLINSKA, B ASHWELL, JD TI EXPRESSION OF THE V-SRC TYROSINE KINASE IN A T-CELL HYBRIDOMA POTENTIATES T-CELL RECEPTOR (TCR)-MEDIATED SIGNALING SO FASEB JOURNAL LA English DT Meeting Abstract C1 PRI DYNCORP,BCDP,FREDERICK,MD. NCI,FREDERICK CANC RES FACIL,BRMP,FREDERICK,MD 21701. NCI,NAVAL MED RES INST,BETHESDA,MD 20892. NCI,MED BRANCH,BETHESDA,MD 20892. NCI,BRMP,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1336 EP A1336 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002428 ER PT J AU PALIOGIANI, F ANASTASSIOU, ED BALOW, JP YAMADA, H BALOW, JE BOUMPAS, DT AF PALIOGIANI, F ANASTASSIOU, ED BALOW, JP YAMADA, H BALOW, JE BOUMPAS, DT TI CYCLIC-AMP REGULATION OF LYMPHOKINE GENE-EXPRESSION SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A992 EP A992 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000438 ER PT J AU PARK, DJ KIM, HWR RHEE, SG AF PARK, DJ KIM, HWR RHEE, SG TI ACTIVATION OF T-CELL RECEPTOR CD-3 COMPLEX ELICITS PHOSPHORYLATION OF PLC-GAMMA-1 AT TYROSINE AND SERINE RESIDUES SO FASEB JOURNAL LA English DT Meeting Abstract C1 NHLBI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A991 EP A991 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000435 ER PT J AU PARK, SS WALKER, W AOYAMA, T LAPENSON, D WAXMAN, DJ GONZALEZ, FJ GELBOIN, HV AF PARK, SS WALKER, W AOYAMA, T LAPENSON, D WAXMAN, DJ GONZALEZ, FJ GELBOIN, HV TI MONOCLONAL-ANTIBODIES THAT DETECT CYTOCHROME-B5 OF RAT AND RABBIT AND EXPRESSED FROM HUMAN CDNA SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,BETHESDA,MD 20892. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1164 EP A1164 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001429 ER PT J AU PAULAIS, M TURNER, RJ AF PAULAIS, M TURNER, RJ TI BETA-ADRENERGIC REGULATION OF THE RAT PAROTID ACINAR NA+-K+-2CL- COTRANSPORTER SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIDR,CIPCB,BETHESDA,MD 20892. RI Paulais, Marc/E-5623-2017 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1018 EP A1018 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000592 ER PT J AU PERRY, LL LODMELL, DL AF PERRY, LL LODMELL, DL TI IMMUNITY TO STREET RABIES VIRUS IN MICE SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAID,ROCKY MT LABS,HAMILTON,MT 59840. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1094 EP A1094 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001023 ER PT J AU POLITIS, AD SIVO, J DRIGGERS, P OZATO, K VOGEL, S AF POLITIS, AD SIVO, J DRIGGERS, P OZATO, K VOGEL, S TI RAPID INDUCTION BY IFN-GAMMA AND REGULATION OF MESSENGER-RNA WHICH ENCODES A PUTATIVE TRANSACTING FACTOR (ICSBP) IN MURINE MACROPHAGES SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NICHHD,LDMI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A963 EP A963 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000274 ER PT J AU POSTON, JM PARENTEAU, GL FLYNN, DM AF POSTON, JM PARENTEAU, GL FLYNN, DM TI EFFECTS OF ANOXIA AND REPERFUSION ON HEART-MUSCLE SO FASEB JOURNAL LA English DT Meeting Abstract C1 NHLBI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1275 EP A1275 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002077 ER PT J AU PREUSCH, PC AF PREUSCH, PC TI THIOREDOXIN IS PROBABLY NOT THE PHYSIOLOGICAL REDUCTANT OF VITAMIN-K EPOXIDE SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIH,DIV RES GRANTS,BETHESDA,MD 20892. UNIV AKRON,DEPT CHEM,AKRON,OH 44325. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A944 EP A944 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000165 ER PT J AU PRINCIPATO, MA MUSZYNSKI, K TROPPMAIR, J RAYBOURNE, RB RAPP, UR AF PRINCIPATO, MA MUSZYNSKI, K TROPPMAIR, J RAYBOURNE, RB RAPP, UR TI DERIVATION OF A MAC-1+ MACROPHAGE CELL-LINE FROM A THY-1+ LY-5(B220) B-LINEAGE CELL-LINE SO FASEB JOURNAL LA English DT Meeting Abstract C1 US FDA,DIV MICROBIOL,WASHINGTON,DC 20204. NCI,VIRAL CARCINOGENESIS LAB,FREDERICK,MD 21701. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1379 EP A1379 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002675 ER PT J AU RANZENBACH, MR PLITT, JR KUMAR, AJ PATRONAS, N KOO, E ALEXANDER, GE ALEXANDER, EL AF RANZENBACH, MR PLITT, JR KUMAR, AJ PATRONAS, N KOO, E ALEXANDER, GE ALEXANDER, EL TI CNS DISEASE IN SJOGRENS-SYNDROME (CNS-SS) - ROLE OF ANTI-RO (SS-A) ANTIBODIES SO FASEB JOURNAL LA English DT Meeting Abstract C1 JOHNS HOPKINS UNIV,SCH MED,BALTIMORE,MD 21205. NIH,BETHESDA,MD 20892. NR 0 TC 5 Z9 5 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1386 EP A1386 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002720 ER PT J AU RESTIFO, NP ESQUIVEL, F ASHER, AL STOTTER, H BARTH, RJ BENNINK, JR YEWDELL, JW MULE, JJ ROSENBERG, SA AF RESTIFO, NP ESQUIVEL, F ASHER, AL STOTTER, H BARTH, RJ BENNINK, JR YEWDELL, JW MULE, JJ ROSENBERG, SA TI ANTIGEN PRESENTATION DEFECT IN A MURINE MCA SARCOMA SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,BETHESDA,MD 20892. NIAID,BETHESDA,MD 20892. RI Restifo, Nicholas/A-5713-2008; yewdell, jyewdell@nih.gov/A-1702-2012 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1333 EP A1333 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002408 ER PT J AU RITTER, JK SHEEN, YY CHEN, F TRAN, HM OWENS, IS AF RITTER, JK SHEEN, YY CHEN, F TRAN, HM OWENS, IS TI 2 HUMAN LIVER BILIRUBIN UDP-GLUCURONOSYLTRANSFERASES WITH IDENTICAL C-TERMINI RESULT FROM 5'-ALTERNATIVE SPLICING SO FASEB JOURNAL LA English DT Meeting Abstract C1 NICHHD,HUMAN GENET BRANCH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1173 EP A1173 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001480 ER PT J AU ROBBINS, PF HAND, PH SCHLOM, J AF ROBBINS, PF HAND, PH SCHLOM, J TI EXPRESSION OF THE HUMAN CARCINOEMBRYONIC ANTIGEN IN A TRANSDUCED MOUSE COLON-TUMOR CELL-LINE SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1355 EP A1355 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002536 ER PT J AU ROMKES, M FALETTO, MB BLAISDELL, J RAUCY, JL LASKER, JM GOLDSTEIN, JA AF ROMKES, M FALETTO, MB BLAISDELL, J RAUCY, JL LASKER, JM GOLDSTEIN, JA TI CLONING AND EXPRESSION OF COMPLEMENTARY DNAS FOR MULTIPLE MEMBERS OF THE HUMAN CYTOCHROME-P4502C SUBFAMILY SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIEHS,RES TRIANGLE PK,NC 27709. UNIV NEW MEXICO,ALBUQUERQUE,NM 87131. VET ADM MED CTR,BRONX,NY 10468. MT SINAI MED SCH,BRONX,NY 10468. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1163 EP A1163 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001422 ER PT J AU SAHAKIAN, JA SHAMES, BD LEVINE, RL AF SAHAKIAN, JA SHAMES, BD LEVINE, RL TI METAL-CATALYZED OXIDATION OF GLUTAMINE-SYNTHETASE - SUSCEPTIBILITY TO PROTEOLYSIS REQUIRES OXIDATION OF HISTIDINE-RESIDUES AT BOTH METAL-BINDING SITES SO FASEB JOURNAL LA English DT Meeting Abstract C1 NHLBI,BIOCHEM LAB,BETHESDA,MD 20892. RI Levine, Rodney/D-9885-2011 NR 0 TC 7 Z9 7 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1177 EP A1177 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001505 ER PT J AU SALBE, AD ALBANES, D WINICK, M TAYLOR, PR LEVANDER, OA AF SALBE, AD ALBANES, D WINICK, M TAYLOR, PR LEVANDER, OA TI EFFECT OF ELEVATED SELENIUM INTAKES ON MAMMARY CELL-PROLIFERATION IN RATS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USDA,BELTSVILLE HUMAN NUTR RES CTR,BELTSVILLE,MD 20705. NCI,DCPC,BETHESDA,MD 20892. RI Albanes, Demetrius/B-9749-2015 NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1444 EP A1444 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55003051 ER PT J AU SANDA, MG BOLTON, E MULE, JJ ROSENBERG, SA AF SANDA, MG BOLTON, E MULE, JJ ROSENBERG, SA TI INVIVO ADMINISTRATION OF M-CSF INDUCES PERITONEAL-EXUDATE CELLS THAT MEDIATE ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITY SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,SURG BRANCH,BETHESDA,MD 20892. RI Sanda, Martin/A-6202-2013; Sanda, Martin/B-2023-2015 NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1333 EP A1333 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002407 ER PT J AU SATO, K MASUDA, T DOBSON, GP MALLOY, C VEECH, RL AF SATO, K MASUDA, T DOBSON, GP MALLOY, C VEECH, RL TI PERFUSION OF WORKING HEART WITH 5-MM [SIGMA-PI] LEADS TO MITOCHONDRIAL SEQUESTRATION OF ATP AND MG WITH FUNTIONAL IMPAIRMENT OF HEART SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAAA,ROCKVILLE,MD 20852. UNIV TEXAS,SCH MED,CTR NMR,DALLAS,TX 75235. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1427 EP A1427 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002957 ER PT J AU SCHAAD, NC YU, L KLEIN, DC AF SCHAAD, NC YU, L KLEIN, DC TI ELEVATION OF INTRACELLULAR CA++ POTENTIATES CYCLIC-AMP STIMULATION OF PINEAL N-ACETYLTRANSFERASE SO FASEB JOURNAL LA English DT Meeting Abstract C1 NICHHD,DEV NEUROBIOL LAB,NEUROENDOCRINOL SECT,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1102 EP A1102 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001070 ER PT J AU SCHWEIKL, H LINKO, P NAGORNEY, D TAYLOR, JA GOLDSTEIN, JA AF SCHWEIKL, H LINKO, P NAGORNEY, D TAYLOR, JA GOLDSTEIN, JA TI VARIABLE EXPRESSION OF CYTOCHROME-P4501A2 IN HUMAN LIVER SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIEHS,RES TRIANGLE PK,NC 27709. MAYO CLIN & MAYO FDN,ROCHESTER,MN 55905. RI Schweikl, Helmut/C-2998-2013 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1164 EP A1164 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001428 ER PT J AU SERVENTI, IM CAVANAUGH, E TSUCHIYA, M PRICE, SR NIGHTINGALE, M MOSS, J VAUGHAN, M AF SERVENTI, IM CAVANAUGH, E TSUCHIYA, M PRICE, SR NIGHTINGALE, M MOSS, J VAUGHAN, M TI STRUCTURE OF THE BOVINE GENE FOR ADP-RIBOSYLATION FACTOR-II, A APPROXIMATELY-20 KDA GUANINE-NUCLEOTIDE BINDING-PROTEIN THAT ACTIVATES CHOLERA-TOXIN SO FASEB JOURNAL LA English DT Meeting Abstract C1 NHLBI,CELLULAR METAB LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1171 EP A1171 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001468 ER PT J AU SHINYA, E FUJII, H DEFIGUIREDO, P SHIMADA, T AF SHINYA, E FUJII, H DEFIGUIREDO, P SHIMADA, T TI IDENTIFICATION OF 2 INITIATOR ELEMENTS IN THE HUMAN DIHYDROFOLATE-REDUCTASE GENE BIDIRECTIONAL PROMOTER SO FASEB JOURNAL LA English DT Meeting Abstract C1 NHLBI,CLIN HEMATOL BRANCH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1171 EP A1171 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001467 ER PT J AU SILVERMAN, JA RAUNIO, H GANT, TW MARINO, PA THORGEIRSSON, SS AF SILVERMAN, JA RAUNIO, H GANT, TW MARINO, PA THORGEIRSSON, SS TI CLONING AND SEQUENCING OF THE 1ST RAT MDR CDNA SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,EXPTL CARCINOGENESIS LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1187 EP A1187 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001563 ER PT J AU SINHA, R BLOCK, G MANGELS, AR LEVANDER, OA PATTERSON, B MOORHEAD, MM TAYLOR, PR AF SINHA, R BLOCK, G MANGELS, AR LEVANDER, OA PATTERSON, B MOORHEAD, MM TAYLOR, PR TI DETERMINANTS OF PLASMA ASCORBIC-ACID IN HEALTHY-MALES SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,BETHESDA,MD 20892. USDA,BELTSVILLE HUMAN NUTR RES CTR,BELTSVILLE,MD 20705. RI Block, Gladys/E-3304-2010; Sinha, Rashmi/G-7446-2015 OI Sinha, Rashmi/0000-0002-2466-7462 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1444 EP A1444 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55003054 ER PT J AU SMITH, JC MICOZZI, MS BROWN, ED EDWARDS, BK BIERI, JG TAYLOR, PR KHACHIK, F BEECHER, GR AF SMITH, JC MICOZZI, MS BROWN, ED EDWARDS, BK BIERI, JG TAYLOR, PR KHACHIK, F BEECHER, GR TI PLASMA CAROTENOIDS IN MEN FED BETA-CAROTENE OR VEGETABLES FOR 6 WEEKS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USDA,HUMAN NUTR RES CTR,BELTSVILLE,MD 20705. NCI,BETHESDA,MD 20892. RI Khachik, Frederick/C-5055-2009 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1073 EP A1073 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000907 ER PT J AU SMITH, PD BRANDES, ME WAHL, SM MAI, UEH AF SMITH, PD BRANDES, ME WAHL, SM MAI, UEH TI THE ACCUMULATION OF MONONUCLEAR PHAGOCYTES IN INFLAMED MUCOSA IS LIKELY DUE TO THE RECRUITMENT OF CIRCULATING MONOCYTES AND NOT LAMINA PROPRIA MACROPHAGES SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIDR,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A981 EP A981 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000375 ER PT J AU SOBEL, ME TARABOLETTI, G CASTRONOVO, V AF SOBEL, ME TARABOLETTI, G CASTRONOVO, V TI FUNCTIONAL DOMAINS OF THE 67 KDA LAMININ RECEPTOR PRECURSOR SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIH,PATHOL LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1064 EP A1064 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000855 ER PT J AU STADTMAN, TC DAVIS, JN AF STADTMAN, TC DAVIS, JN TI GLYCINE REDUCTASE PROTEIN-C - PURIFICATION AND CHARACTERIZATION OF ITS ROLE IN THE REDUCTIVE CLEAVAGE OF SE-CARBOXYMETHYL-SE-PROTEIN-A SO FASEB JOURNAL LA English DT Meeting Abstract C1 NHLBI,BIOCHEM LAB,BETHESDA,MD 20892. NR 1 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1195 EP A1195 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001610 ER PT J AU SVETIC, A FINKELMAN, FD DIEFFENBACH, CW SCOTT, DE STEINBERG, AD GAUSE, WC AF SVETIC, A FINKELMAN, FD DIEFFENBACH, CW SCOTT, DE STEINBERG, AD GAUSE, WC TI CYTOKINE GENE-EXPRESSION DURING AN INVIVO PRIMARY IMMUNE-RESPONSE SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIFORMED SERV UNIV HLTH SCI,DEPT MICROBIOL,BETHESDA,MD 20814. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. UNIFORMED SERV UNIV HLTH SCI,DEPT PATHOL,BETHESDA,MD 20814. NIAMS,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A980 EP A980 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000370 ER PT J AU SWIETER, M MIDURA, R OLIVER, C BERENSTEIN, E HASCALL, V MERGENHAGEN, SE SIRAGANIAN, R AF SWIETER, M MIDURA, R OLIVER, C BERENSTEIN, E HASCALL, V MERGENHAGEN, SE SIRAGANIAN, R TI RAT BASOPHILIC LEUKEMIA (RBL-2H3) CELLS ACQUIRE RESPONSIVENESS TO COMPOUND 48/80 BY COCULTURE WITH 3T3 FIBROBLASTS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIDR,BETHESDA,MD 20892. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1085 EP A1085 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000975 ER PT J AU TAFFS, R REDEGELD, F SITKOVSKY, M AF TAFFS, R REDEGELD, F SITKOVSKY, M TI MODULATION OF CYTOLYTIC LYMPHOCYTE-T RESPONSES BY AN INHIBITOR OF SERINE/THREONINE PROTEIN PHOSPHATASE(S) SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAID,BETHESDA,MD 20892. RI Redegeld, Frank/O-6534-2016 OI Redegeld, Frank/0000-0001-8830-7960 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1456 EP A1456 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55003121 ER PT J AU TANAKA, T CHU, CC PAUL, WE AF TANAKA, T CHU, CC PAUL, WE TI INHIBITION OF IG SECRETION BY AN ANTISENSE OLIGODEOXYNUCLEOTIDE COMPLEMENTARY TO AN I-GAMMA-2B SEQUENCE SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAID,IMMUNOL LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1000 EP A1000 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000483 ER PT J AU TAYLOR, CE FAUNTLEROY, MB BAKER, PJ STASHAK, PW AF TAYLOR, CE FAUNTLEROY, MB BAKER, PJ STASHAK, PW TI EFFECTS OF CYTOKINES ON THE ACTIVITY OF ANTIGEN SPECIFIC SUPPRESSOR T-CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAID,IMMUNOGEN LAB,ROCKVILLE,MD 20852. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1092 EP A1092 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001011 ER PT J AU THOMPSON, HL FOX, CH METCALFE, DD AF THOMPSON, HL FOX, CH METCALFE, DD TI DEMONSTRATION OF RANDOM MOVEMENT OF MAST-CELLS ON EXTRACELLULAR-MATRIX COMPONENTS INVITRO SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1009 EP A1009 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000538 ER PT J AU THYPHRONITIS, G KING, CL BANCHEREAU, J FINKELMAN, FD AF THYPHRONITIS, G KING, CL BANCHEREAU, J FINKELMAN, FD TI ANTI-CD23 MAB ENHANCES THE IGE RESPONSE MADE BY HUMAN B-CELLS CULTURED WITH IL-4 PLUS EPSTEIN-BARR-VIRUS (EBV) SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. NIAID,BETHESDA,MD 20892. SCHERING PLOUGH CORP,DARDILLY,FRANCE. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1371 EP A1371 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002634 ER PT J AU TSAI, SC HAUN, RS TSUCHIYA, M MOSS, J VAUGHAN, M AF TSAI, SC HAUN, RS TSUCHIYA, M MOSS, J VAUGHAN, M TI ISOLATION AND CHARACTERIZATION OF THE HUMAN GENE FOR ADP-RIBOSYLATION FACTOR-III, A 20-KDA GUANINE NUCLEOTIDE-BINDING PROTEIN ACTIVATOR OF CHOLERA-TOXIN SO FASEB JOURNAL LA English DT Meeting Abstract C1 NHLBI,CELLULAR METAB LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1173 EP A1173 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001479 ER PT J AU TSUKAMOTO, K HEARING, VJ AF TSUKAMOTO, K HEARING, VJ TI MAMMALIAN MELANOGENESIS IS REGULATED BY MULTIPLE TYROSINASE-RELATED GENE-PRODUCTS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIH,CELL BIOL LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1203 EP A1203 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001658 ER PT J AU TUNG, KSK RHIM, SH LUO, AM YULE, T ALLEN, P ROBEY, F MILLAR, S DEAN, J AF TUNG, KSK RHIM, SH LUO, AM YULE, T ALLEN, P ROBEY, F MILLAR, S DEAN, J TI AUTOIMMUNE-DISEASE OF OVARY (MAO) IS INDUCED BY A PEPTIDE FROM MURINE ZONA-PELLUCIDA (ZP) PROTEIN, ZP3 SO FASEB JOURNAL LA English DT Meeting Abstract C1 WASHINGTON UNIV,SCH MED,ST LOUIS,MO 63110. NIH,CELLULAR DEV BIOL,BETHESDA,MD 20892. NIH,CELLULAR DEV & ONCOL,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1088 EP A1088 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000992 ER PT J AU UNDERWOOD, BA RAHMATHULLAH, L THULASIRAJ, RD MILTON, RC AF UNDERWOOD, BA RAHMATHULLAH, L THULASIRAJ, RD MILTON, RC TI MORBIDITY AND GROWTH ARE NOT AFFECTED BY A WEEKLY LOW-DOSE VITAMIN-A SUPPLEMENT TO CHILDREN IN SOUTHERN INDIA SO FASEB JOURNAL LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. ARAVIND EYE HOSP,MADURAI,INDIA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1080 EP A1080 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000945 ER PT J AU WATANABE, T WADA, N CHOU, JY AF WATANABE, T WADA, N CHOU, JY TI STRUCTURAL AND FUNCTIONAL-ANALYSIS OF HUMAN GERM-CELL ALKALINE-PHOSPHATASE BY SITE-SPECIFIC MUTAGENESIS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NICHHD,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1181 EP A1181 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001526 ER PT J AU WOLFF, EC JAKUS, J PARK, MH FOLK, JE AF WOLFF, EC JAKUS, J PARK, MH FOLK, JE TI STRUCTURE-FUNCTION STUDIES WITH DEOXYHYPUSINE SYNTHASE, THE 1ST ENZYME IN THE BIOSYNTHESIS OF HYPUSINE IN EIF-4D SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIDR,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1152 EP A1152 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001360 ER PT J AU WORLAND, PJ SAUSVILLE, EA AF WORLAND, PJ SAUSVILLE, EA TI CALCIUM DEPENDENT PROTEIN-PHOSPHORYLATION IN SCLC SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,DEPT CANC TREATMENT,CPB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1043 EP A1043 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000740 ER PT J AU WU, SM SEGAL, DM ASHWELL, JD AF WU, SM SEGAL, DM ASHWELL, JD TI STIMULATION OF T-CELLS USING ANTIBODY HETEROCONJUGATES CONTAINING ANTI-TCR AND ANTI-MHC CLASS-II FAB FRAGMENTS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,BIOL RESPONSE MODIFIERS PROGRAM,BETHESDA,MD 20892. NCI,EXPTL IMMUNOL BRANCH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1457 EP A1457 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55003130 ER PT J AU YEH, GC POORE, CM LOPACZYNSKA, J PHANG, JM AF YEH, GC POORE, CM LOPACZYNSKA, J PHANG, JM TI P-GLYCOPROTEIN IN ADRIAMYCIN-RESISTANT CELLS FUNCTIONS AS AN EFFLUX PUMP FOR BENZOPYRENE, A CHEMICAL CARCINOGEN SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,FREDERICK CANC RES & DEV CTR,NUTR & MOLEC REGULAT LAB,FREDERICK,MD 21702. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A930 EP A930 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000087 ER PT J AU YU, G FU, Y KAHN, R FELSTED, R AF YU, G FU, Y KAHN, R FELSTED, R TI EXPRESSION, MUTATION AND LOCALIZATION OF HIV NEF PROTEIN IN TRANSFECTED COS CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,DCT,DTP,BIOL CHEM LAB,BETHESDA,MD 20892. NHLBI,CARDIOL BRANCH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1266 EP A1266 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002023 ER PT J AU ZHOU, D KORZEKWA, K POULOS, T CHEN, S AF ZHOU, D KORZEKWA, K POULOS, T CHEN, S TI STRUCTURE-FUNCTION STUDIES OF HUMAN AROMATASE BY SITE-DIRECTED MUTAGENESIS SO FASEB JOURNAL LA English DT Meeting Abstract C1 CITY HOPE NATL MED CTR,BECKMAN RES INT,DIV IMMUNOL,DUARTE,CA 91010. NCI,MOLEC CARCINOGENESIS LAB,BETHESDA,MD 20892. CTR ADV RES BIOTECHNOL,ROCKVILLE,MD 20850. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1161 EP A1161 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001409 ER PT J AU GAK, E YANIV, A SHERMAN, L IANCONESCU, M TRONICK, SR GAZIT, A AF GAK, E YANIV, A SHERMAN, L IANCONESCU, M TRONICK, SR GAZIT, A TI LYMPHOPROLIFERATIVE DISEASE VIRUS OF TURKEYS - SEQUENCE-ANALYSIS AND TRANSCRIPTIONAL ACTIVITY OF THE LONG TERMINAL REPEAT SO GENE LA English DT Article DE RECOMBINANT DNA; CHLORAMPHENICOL ACETYLTRANSFERASE; RETROVIRUSES; AVIAN LEUKOSIS-SARCOMA VIRUSES ID CELL LEUKEMIA-VIRUS; SARCOMA-VIRUS; MOLECULAR-CLONING; GENE-EXPRESSION; SIMIAN VIRUS-40; DNA; ACTIVATION; ENHANCER; REPLICATION; ETIOLOGY AB The lymphoproliferative disease virus (LPDV) is the etiological agent of a lymphoproliferative disease that naturally occurs in turkeys. Recently, we have cloned the LPDV provirus and established it as a replication-competent genome devoid of a viral oncogene [Gak et al., J. Virol. 63 (1989) 2877-2880]. This report presents the nucleotide sequence of its long terminal repeat (LTR) and establishes it as a potent transcriptional element. Several features of the LPDV LTR were similar to those found in the LTRs of the avian sarcoma-leukemia viruses (ASLV) and include the primer-binding site (tRNA(Trp)), the polypurine tract, the organization of the polyadenylation signal, the complexities of the U3, R and U5 regions, as well as a potential secondary structure in U5-R. The LTR sequence diverges significantly from the ASLV LTRs, which share a common structure and have extensive sequence homology mainly in the R and U5 domains. These findings support the conclusion that LPDV represents a distinct class of avian retrovirus, evolutionarily related to the ASLV family. C1 TEL AVIV UNIV,SACKLER SCH MED,DEPT HUMAN MICROBIOL,IL-69978 TEL AVIV,ISRAEL. KIMRON VET INST,DEPT AVIAN PATHOL,BET DAGAN,ISRAEL. NCI,CELLULAR & MOLEC BIOL LAB,BETHESDA,MD 20892. NR 41 TC 9 Z9 9 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-1119 J9 GENE JI Gene PD MAR 15 PY 1991 VL 99 IS 2 BP 157 EP 162 DI 10.1016/0378-1119(91)90122-R PG 6 WC Genetics & Heredity SC Genetics & Heredity GA FK291 UT WOS:A1991FK29100003 PM 2022329 ER PT J AU SCAPPINO, LA CHU, C GRITZMACHER, CA AF SCAPPINO, LA CHU, C GRITZMACHER, CA TI EXTENDED NUCLEOTIDE-SEQUENCE OF THE SWITCH REGION OF THE MURINE GENE ENCODING IMMUNOGLOBULIN-E SO GENE LA English DT Note DE RECOMBINANT DNA; GERMLINE; REPEAT UNITS; S-EPSILON CONSENSUS SEQUENCE ID EPSILON; EXPRESSION; VECTORS; CLONING AB The nucleotide sequence of the switch region (S-epsilon) of the gene encoding murine IgE was determined from a germline DNA clone. The sequence extends 1.7 kb 5' to the previously published S-epsilon sequence. Another 33 repeat units were located by comparison to the S-epsilon consensus sequence. Therefore, the complete S-epsilon repetitive sequence consists of 53 repeat units contained in a region about 2.5 kb long. C1 SCRIPPS RES INST, DEPT MOLEC & EXPTL MED, BCR-4, LA JOLLA, CA 92037 USA. MED BIOL INST, LA JOLLA, CA 92037 USA. NIAID, IMMUNOL LAB, BETHESDA, MD 20892 USA. FU NIAID NIH HHS [AI25086] NR 10 TC 4 Z9 4 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-1119 J9 GENE JI Gene PD MAR 15 PY 1991 VL 99 IS 2 BP 295 EP 296 DI 10.1016/0378-1119(91)90142-X PG 2 WC Genetics & Heredity SC Genetics & Heredity GA FK291 UT WOS:A1991FK29100023 PM 2022340 ER PT J AU BERGSTROM, LK HOLLAND, EJ SHAPIRO, RS QIAN, L CHAN, CC AF BERGSTROM, LK HOLLAND, EJ SHAPIRO, RS QIAN, L CHAN, CC TI INTERFERON INTERACTIONS IN THE REGULATION OF MHC CLASS-II ANTIGENS IN THE HUMAN CORNEA SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 UNIV MINNESOTA,DEPT OPHTHALMOL,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,DEPT PEDIAT,MINNEAPOLIS,MN 55455. NEI,IMMUNOL LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 677 EP 677 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76200053 ER PT J AU WHITCUP, SM WAKEFIELD, D LOPEZ, JS LI, Q NUSSENBLATT, RB CHAN, CC AF WHITCUP, SM WAKEFIELD, D LOPEZ, JS LI, Q NUSSENBLATT, RB CHAN, CC TI ROLE OF DEFENSINS AND ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE-1 (ELAM-1) IN ENDOTOXIN INDUCED UVEITIS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,IMMUNOL LAB,BETHESDA,MD 20892. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 677 EP 677 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76200054 ER PT J AU GLASNER, PD SILVEIRA, C MARTINA, MC SILVEIRA, S CAMARGO, M KRUSZONMORAN, D BURNIER, M KASLOW, RA NUSSENBLATT, RB BELFORT, R AF GLASNER, PD SILVEIRA, C MARTINA, MC SILVEIRA, S CAMARGO, M KRUSZONMORAN, D BURNIER, M KASLOW, RA NUSSENBLATT, RB BELFORT, R TI THE PREVALENCE OF OCULAR TOXOPLASMOSIS IN A RURAL-POPULATION IN SOUTHERN BRAZIL SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NIAID,BETHESDA,MD 20892. NEI,BETHESDA,MD 20892. ESCOLA PAULISTA MED SCH,BR-04023 SAO PAULO,BRAZIL. LAB FLEURY,SAO PAULO,BRAZIL. CLIN SILVEIRA,EREXIM,RS,BRAZIL. RI Belfort Jr, Rubens/E-2252-2012 OI Belfort Jr, Rubens/0000-0002-8422-3898 NR 1 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 681 EP 681 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76200075 ER PT J AU JUN, L WETZEL, MG OBRIEN, PJ AF JUN, L WETZEL, MG OBRIEN, PJ TI TRANSPORT OF W-3 FATTY-ACIDS FROM THE INTESTINE TO THE RETINA SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 701 EP 701 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76200178 ER PT J AU VITALE, S WEST, S HALLFRISCH, J MULLER, D SINGH, VN AF VITALE, S WEST, S HALLFRISCH, J MULLER, D SINGH, VN TI PLASMA VITAMIN-C, VITAMIN-E, AND BETA-CAROTENE LEVELS AND RISK OF CATARACT SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 JOHNS HOPKINS UNIV,DANA CTR PREVENT OPHTHALMOL,BALTIMORE,MD 21218. NIA,GERONTOL RES CTR,BALTIMORE,MD 21224. HOFFMANN LA ROCHE INC,NUTLEY,NJ 07110. NR 0 TC 4 Z9 4 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 723 EP 723 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76200285 ER PT J AU WU, SY LESKER, MC CHYLACK, LT HYMAN, L UNDERWOOD, B SPERDUTO, R KHU, P AF WU, SY LESKER, MC CHYLACK, LT HYMAN, L UNDERWOOD, B SPERDUTO, R KHU, P TI THE LENS OPACITIES CASE-CONTROL STUDY .2. BIOCHEMICAL RISK-FACTORS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 SUNY STONY BROOK,STONY BROOK,NY 11794. CTR CLIN CATARACT RES,BOSTON,MA. NEI,BETHESDA,MD 20892. NR 0 TC 2 Z9 2 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 723 EP 723 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76200284 ER PT J AU OLD, SE CARPER, DA AF OLD, SE CARPER, DA TI INTRODUCTION OF RAT LENS ALDOSE REDUCTASE INTO TRANSGENIC MICE SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. NR 3 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 749 EP 749 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76200416 ER PT J AU ANDERSON, DH HAGEMAN, GS GUERIN, CJ FLANDERS, KC AF ANDERSON, DH HAGEMAN, GS GUERIN, CJ FLANDERS, KC TI IMMUNOLOCALIZATION OF TRANSFORMING GROWTH-FACTOR (TGF)-BETA-1, TGF-BETA-2, AND TGF-BETA-3 IN MAMMALIAN RETINAS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 UNIV CALIF SANTA BARBARA,NEUROSCI RES INST,SANTA BARBARA,CA 93106. ST LOUIS UNIV,BETHESDA EYE INST,ST LOUIS,MO 63103. NCI,CHEMOPREVENT LAB,BETHESDA,MD 20892. NR 1 TC 5 Z9 5 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 754 EP 754 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76200437 ER PT J AU ARNOLD, DR WALDBILLIG, RJ SCHOEN, TJ CHADER, GJ AF ARNOLD, DR WALDBILLIG, RJ SCHOEN, TJ CHADER, GJ TI THE CILIARY BODY - A POTENTIAL SITE OF SYNTHESIS FOR VITREAL INSULIN-LIKE GROWTH-FACTOR BINDING PROTEIN-2 (IGFBP-2) SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. NR 0 TC 2 Z9 2 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 755 EP 755 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76200443 ER PT J AU TOMBRANTINK, J CURTIS, FL JOHNSON, LV CHADER, GJ AF TOMBRANTINK, J CURTIS, FL JOHNSON, LV CHADER, GJ TI PARTIAL AMINO-ACID-SEQUENCE AND NEUROTROPHIC ACTIVITY OF A NOVEL HUMAN PIGMENT EPITHELIUM-DERIVED FACTOR (PEDF) SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,LRCMB,BETHESDA,MD 20892. UNIV SO CALIF,SCH MED,LOS ANGELES,CA 90089. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 755 EP 755 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76200444 ER PT J AU BURNIET, MN CHAN, CC MCLEAN, IW DESMET, M RUBIN, B BELFORT, R NUSSENBLATT, RB AF BURNIET, MN CHAN, CC MCLEAN, IW DESMET, M RUBIN, B BELFORT, R NUSSENBLATT, RB TI THE USE OF VARIOUS IMMUNOHISTOPATHOLOGIC TECHNIQUES IN THE DIAGNOSIS OF CYTOMEGALOVIRUS (CMV) RETINITIS IN AIDS PATIENTS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,IMMUNOL LAB,BETHESDA,MD 20892. AFIP,DEPT OPHTHALMIC PATHOL,WASHINGTON,DC 20306. RI Belfort Jr, Rubens/E-2252-2012 OI Belfort Jr, Rubens/0000-0002-8422-3898 NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 764 EP 764 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76200482 ER PT J AU LI, AR JOHNSON, MA CHADER, GJ JOHNSON, LV TOMBRANTINK, J AF LI, AR JOHNSON, MA CHADER, GJ JOHNSON, LV TOMBRANTINK, J TI EFFECTS OF INTERPHOTORECEPTOR MATRIX (IPM) ON DIFFERENTIATION OF CULTURED Y-79 RETINOBLASTOMA CELLS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,LRCMB,BETHESDA,MD 20892. UNIV SO CALIF,SCH MED,LOS ANGELES,CA 90089. HOWARD HUGHES MED INST,BETHESDA,MD 20814. NR 1 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 770 EP 770 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76200515 ER PT J AU SATO, S LIN, LR REDDY, V KADOR, PF AF SATO, S LIN, LR REDDY, V KADOR, PF TI NADPH-DEPENDENT REDUCTASES IN CULTURED HUMAN RETINAL-PIGMENT EPITHELIAL (RPE) CELLS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. OAKLAND UNIV,EYE RES INST,ROCHESTER,MI 48063. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 773 EP 773 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76200533 ER PT J AU ASHRAF, F COGAN, DG KRUTH, HS AF ASHRAF, F COGAN, DG KRUTH, HS TI APOLIPOPROTEIN DISTRIBUTION IN THE HUMAN CORNEA SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NIH,BETHESDA,MD 20892. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 775 EP 775 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76200538 ER PT J AU CUTHBERTSON, RA PIATIGORSKY, J AF CUTHBERTSON, RA PIATIGORSKY, J TI SUBTRACTION CDNA CLONING AND DIFFERENTIAL SCREENING IN THE CORNEAL EPITHELIUM AND ENDOTHELIUM SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,MOLEC & DEV BIOL LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 781 EP 781 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76200559 ER PT J AU SAX, CM DONOVAN, DM PIATIGORSKY, J AF SAX, CM DONOVAN, DM PIATIGORSKY, J TI DIFFERENTIAL UTILIZATION OF TRANSCRIPTIONAL REGULATORY ELEMENTS IN TRANSFECTED LENS CELLS AND TRANSGENIC MICE SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,MOLEC DEV BIOL LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 781 EP 781 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76200561 ER PT J AU HOPE, JN HANTEN, GR KIM, JU OVERBEEK, PA HEJTMANCIK, JF AF HOPE, JN HANTEN, GR KIM, JU OVERBEEK, PA HEJTMANCIK, JF TI BETA-3/AL-CRYSTALLIN - EXPRESSION AND MUTATION STUDIES SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,MOLEC DEV BIOL LAB,BETHESDA,MD 20892. BAYLOR UNIV,HOUSTON,TX 77030. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 782 EP 782 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76200563 ER PT J AU NOONAN, DM RAVAZZOLO, R FASSINA, GF ZHU, Z BARRESI, R TOFFENETTI, J ALBINI, A CHADER, GJ AF NOONAN, DM RAVAZZOLO, R FASSINA, GF ZHU, Z BARRESI, R TOFFENETTI, J ALBINI, A CHADER, GJ TI POTENTIAL MECHANISMS REGULATING IRBP GENE-EXPRESSION SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. IST NACL RIC CANC,GENOA,ITALY. UNIV GENOA,I-16126 GENOA,ITALY. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 782 EP 782 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76200566 ER PT J AU PISANO, MM CHEPELINSKY, AB AF PISANO, MM CHEPELINSKY, AB TI TRANSCRIPTIONAL REGULATORY ELEMENTS OF THE GENE ENCODING THE LENS MAJOR INTRINSIC PROTEIN (MIP) SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,MOLEC DEV BIOL LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 782 EP 782 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76200565 ER PT J AU RODRIGUEZ, IR GONZALEZ, P ZIGLER, JS BORRAS, T AF RODRIGUEZ, IR GONZALEZ, P ZIGLER, JS BORRAS, T TI A SPLICE-SITE DELETION THAT CAUSES A DEFECTIVE LAMBDA-CRYSTALLIN IS FOUND IN A CONGENITAL GUINEA-PIG CATARACT SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 782 EP 782 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76200564 ER PT J AU BOULIGNY, R SASAMOTO, Y KAWANO, Y WIGGERT, B CHADER, GJ GERY, I AF BOULIGNY, R SASAMOTO, Y KAWANO, Y WIGGERT, B CHADER, GJ GERY, I TI INDUCTION OF ANERGY BY INTRAVENOUS (IV) ADMINISTRATION OF UVEITOGENIC PEPTIDES - ANALYSIS OF THE MECHANISM SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. HOWARD HUGHES MED INST,BETHESDA,MD. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 790 EP 790 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76200603 ER PT J AU CASPI, RR PARSA, C CHAN, CC GRUBBS, BG BAHMANYAR, S HEREMANS, H BILLIAU, A WIGGERT, B AF CASPI, RR PARSA, C CHAN, CC GRUBBS, BG BAHMANYAR, S HEREMANS, H BILLIAU, A WIGGERT, B TI NEUTRALIZATION OF ENDOGENOUS INTERFERON-GAMMA EXACERBATES EXPERIMENTAL AUTOIMMUNE UVEORETINITIS IN THE MOUSE MODEL SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. CATHOLIC UNIV LEUVEN,REGA INST MED RES,IMMUNOBIOL LAB,B-3000 LOUVAIN,BELGIUM. NR 0 TC 5 Z9 5 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 790 EP 790 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76200601 ER PT J AU EGWUAGU, CE BAHMANYAR, S ODDO, S CASPI, RR MAHDI, RM BREZIN, AP NUSSENBLATT, RB GERY, I AF EGWUAGU, CE BAHMANYAR, S ODDO, S CASPI, RR MAHDI, RM BREZIN, AP NUSSENBLATT, RB GERY, I TI VARIATIONS IN UVEITOGENIC T-CELL RECEPTOR (TCR) V-BETA-8.2 GENE-PRODUCTS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,IMMUNOL LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 791 EP 791 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76200608 ER PT J AU HARA, Y CASPI, RR WIGGERT, B CHADER, J WILBANKS, G STREILEIN, JW AF HARA, Y CASPI, RR WIGGERT, B CHADER, J WILBANKS, G STREILEIN, JW TI EFFECT OF ACAID INDUCTION ON EXPRESSION OF IRBP-SPECIFIC DELAYED-HYPERSENSITIVITY AND EAU IN MICE SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 UNIV MIAMI,SCH MED,DEPT MICROBIOL & IMMUNOL,MIAMI,FL 33152. UNIV MIAMI,SCH MED,DEPT OPHTHALMOL,MIAMI,FL 33152. NEI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 791 EP 791 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76200605 ER PT J AU VANDENBUSSCHE, E SAUNDERS, RC ORBAN, GA AF VANDENBUSSCHE, E SAUNDERS, RC ORBAN, GA TI MT LESIONS IMPAIR MONKEY SPEED DISCRIMINATION SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 CATHOLIC UNIV LEUVEN,NEURO & PSYCHOFYSIOL LAB,B-3000 LOUVAIN,BELGIUM. NIMH,CLIN BRAIN DISORDERS BRANCH,BETHESDA,MD 20892. NR 1 TC 5 Z9 5 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 823 EP 823 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76200772 ER PT J AU JIMENEZ, J MEROLA, L GARLAND, D AF JIMENEZ, J MEROLA, L GARLAND, D TI A PROTEIN THAT PROTECTS AGAINST THIOL DEPENDENT METAL-CATALYZED OXIDATION SYSTEMS IS PRESENT IN BOVINE LENS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. NR 2 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 850 EP 850 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76200897 ER PT J AU VONSCHANTZ, M NARFSTROM, K SHINOHARA, T WIGGERT, B CHADER, GJ VANVEEN, T AF VONSCHANTZ, M NARFSTROM, K SHINOHARA, T WIGGERT, B CHADER, GJ VANVEEN, T TI WESTERN BLOTTING OF PHOTORECEPTOR-SPECIFIC PROTEINS IN THE ABYSSINIAN CAT MODEL OF RETINAL DEGENERATION SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 UNIV AGR SCI UPPSALA,DEPT SURG & MED,UPPSALA,SWEDEN. UNIV LUND,DEPT ZOOL,S-22101 LUND,SWEDEN. NEI,BETHESDA,MD 20892. NR 1 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 889 EP 889 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201082 ER PT J AU SCHWARZ, U AF SCHWARZ, U TI TRACKING EYE-MOVEMENTS IN COMPUTER-SIMULATED 3-DIMENSIONS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,LSR,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 896 EP 896 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201115 ER PT J AU BOCH, RA AF BOCH, RA TI ATTENTIVE VISUAL BEHAVIOR AND NEURONAL-ACTIVITY IN THE POSTERIOR PARIETAL CORTEX OF THE RHESUS-MONKEY SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEUROL CLIN,W-7800 FREIBURG,GERMANY. NEI,SENSORIMOTOR RES LAB,BETHESDA,MD 20892. NR 2 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 909 EP 909 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201184 ER PT J AU CARUSO, RC KAISERKUPFER, MI AF CARUSO, RC KAISERKUPFER, MI TI THE FOVEAL FOCAL ELECTRORETINOGRAM IN GYRATE ATROPHY OF THE CHOROID AND RETINA SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,OPHTHALM GENET & CLIN SERV BRANCH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 911 EP 911 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201195 ER PT J AU ROBISON, WG LAVER, N AF ROBISON, WG LAVER, N TI DIABETIC RETINAL MICROANGIOPATHIES IN HUMANS AND ANIMAL-MODELS - SIMILAR HISTOLOGICAL PROGRESSIONS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract ID RETINOPATHY C1 NEI,BETHESDA,MD 20892. NR 4 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 915 EP 915 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201213 ER PT J AU CHAN, CC LI, Q KIKUCHI, T SHINOHARA, T NUSSENBLATT, RB AF CHAN, CC LI, Q KIKUCHI, T SHINOHARA, T NUSSENBLATT, RB TI DETECTION OF THE MESSENGER-RNA OF S-ANTIGEN FROM THE IRISES OF UVEITIC PATIENTS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,IMMUNOL LAB,BETHESDA,MD 20892. NEI,RETINAL CELLS & MOLEC BIOL LAB,BETHESDA,MD 20892. NR 1 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 916 EP 916 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201220 ER PT J AU CHUNG, H FUJINO, Y LI, Q CHAN, CC GERY, I NUSSENBLATT, RB AF CHUNG, H FUJINO, Y LI, Q CHAN, CC GERY, I NUSSENBLATT, RB TI CHRONIC EAU IN PRIMATES - A MODEL FOR CERTAIN UVEITIC CONDITIONS IN MAN SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,IMMUNOL LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 916 EP 916 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201219 ER PT J AU FUJINO, Y ODDO, S NAJAFIAN, F WILDER, RL CHROUSOS, GP STERNBERG, E CHAN, CC NUSSENBLATT, RB CASPI, RR AF FUJINO, Y ODDO, S NAJAFIAN, F WILDER, RL CHROUSOS, GP STERNBERG, E CHAN, CC NUSSENBLATT, RB CASPI, RR TI THE ROLE OF STEROID-HORMONE IN THE REGULATION OF EAU SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. NIA,BETHESDA,MD 20892. NICHHD,BETHESDA,MD 20892. NIMH,BETHESDA,MD 20892. NR 1 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 932 EP 932 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201291 ER PT J AU KAWANO, Y SASAMOTO, Y KOTAKE, S THURAU, SR WIGGERT, B GERY, I AF KAWANO, Y SASAMOTO, Y KOTAKE, S THURAU, SR WIGGERT, B GERY, I TI TRIALS OF VACCINATION AGAINST EXPERIMENTAL AUTOIMMUNE UVEORETINITIS (EAU) WITH A T-CELL RECEPTOR (TCR) PEPTIDE SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. NR 1 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 932 EP 932 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201288 ER PT J AU SASAMOTO, Y BOULIGNY, R KAWANO, Y WIGGERT, B CHADER, GJ GERY, I AF SASAMOTO, Y BOULIGNY, R KAWANO, Y WIGGERT, B CHADER, GJ GERY, I TI IMMUNOMODULATION OF EXPERIMENTAL AUTOIMMUNE UVEORETINITIS (EAU) BY INDUCTION OF ANERGY TOWARD UVEITOGENIC PEPTIDES SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 932 EP 932 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201287 ER PT J AU DESMET, MD BITAR, G WIGGERT, B CHADER, GJ GERY, I NUSSENBLATT, RB AF DESMET, MD BITAR, G WIGGERT, B CHADER, GJ GERY, I NUSSENBLATT, RB TI IMMUNOGENICITY AND PATHOGENICITY OF HUMAN S-ANTIGEN PEPTIDE DETERMINANTS IN THE LEWIS RAT SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 933 EP 933 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201294 ER PT J AU ETO, K SINGH, VK USUKURA, J SUNIL, S SHINOHARA, T AF ETO, K SINGH, VK USUKURA, J SUNIL, S SHINOHARA, T TI MOLECULAR MIMICRY - YEAST HISTONE-H3 INDUCED AUTOIMMUNE UVEITIS IN PRIMATES SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,DEPT RETINAL CELL & MOLEC BIOL,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 933 EP 933 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201296 ER PT J AU LI, O FUJINO, Y WHITCUP, SM NUSSENBLATT, RB CHAN, CC AF LI, O FUJINO, Y WHITCUP, SM NUSSENBLATT, RB CHAN, CC TI ASSOCIATION BETWEEN MAST-CELLS AND THE DEVELOPMENT OF EXPERIMENTAL UVEITIS IN DIFFERENT RAT STRAINS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,IMMUNOL LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 933 EP 933 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201297 ER PT J AU MAHDI, RM CASPI, RR BREZIN, AP NUSSENBLATT, RB GERY, I EGWUAGU, CE AF MAHDI, RM CASPI, RR BREZIN, AP NUSSENBLATT, RB GERY, I EGWUAGU, CE TI CLONING AND COMPLETE SEQUENCE OF THE V-BETA-8.2 GENE SEGMENTS EXPRESSED BY UVEITOGENIC T-CELLS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,IMMUNOL LAB,BETHESDA,MD 20892. NR 1 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 933 EP 933 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201293 ER PT J AU SUNIL, S ETO, K SINGH, VK SHINOHARA, T AF SUNIL, S ETO, K SINGH, VK SHINOHARA, T TI HOMOLOGOUS DETERMINANTS BETWEEN SELF AND NONSELF ANTIGENS IN EAU SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,DEPT RETINAL CELL & MOLEC BIOL,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 933 EP 933 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201295 ER PT J AU BAHMANYAR, S GRUBBS, BG CHAN, CC LI, Q WIGGERT, B NUSSENBLATT, RB CASPI, RR AF BAHMANYAR, S GRUBBS, BG CHAN, CC LI, Q WIGGERT, B NUSSENBLATT, RB CASPI, RR TI THE ROLE OF MAST-CELLS IN EXPERIMENTAL AUTOIMMUNE UVEORETINITIS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. NR 0 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 934 EP 934 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201302 ER PT J AU HARRIS, L ZELENKA, PS AF HARRIS, L ZELENKA, PS TI EXPRESSION OF N-MYC PROTOONCOGENE MESSENGER-RNA IN THE EMBRYONIC CHICKEN LENS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 967 EP 967 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201471 ER PT J AU SHAUGHNESSY, M CHAN, CC WISTOW, G AF SHAUGHNESSY, M CHAN, CC WISTOW, G TI CDNA CLONING OF THE MHC CLASS-II GENE Y-BOX BINDING-PROTEIN FROM MOUSE LENS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,MOLEC & DEV BIOL LAB,BETHESDA,MD 20892. NEI,IMMUNOL LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 967 EP 967 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201469 ER PT J AU WISTOW, G SHAUGHNESSY, M ZELENKA, P LEE, D AF WISTOW, G SHAUGHNESSY, M ZELENKA, P LEE, D TI A LOW-MOLECULAR-WEIGHT PROTEIN ABUNDANT IN EMBRYONIC LENSES IS CLOSELY RELATED TO A LYMPHOKINE SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,MOLEC & DEV BIOL LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 967 EP 967 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201470 ER PT J AU BREWITT, B RINAUDO, J ZELENKA, P AF BREWITT, B RINAUDO, J ZELENKA, P TI OSCILLATIONS OF DNA-SYNTHESIS AND PROTOONCOGENE MESSENGER-RNA EXPRESSION DURING EMBRYONIC CHICK LENS DEVELOPMENT SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 968 EP 968 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201472 ER PT J AU FREDERIKSE, PH DUBIN, R PIATIGORSKY, J AF FREDERIKSE, PH DUBIN, R PIATIGORSKY, J TI DIFFERENTIAL INITIATION SITES FOR ALPHA-B-CRYSTALLIN TRANSCRIPTION SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 968 EP 968 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201476 ER PT J AU JAWORSKI, CJ PIATIGORSKY, J AF JAWORSKI, CJ PIATIGORSKY, J TI PROMOTER ELEMENTS OF THE HUMAN ALPHA-A-CRYSTALLIN GENE SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,MOLEC & DEV BIOL LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 968 EP 968 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201475 ER PT J AU ROTH, HJ DAS, GC PIATIGORSKY, J AF ROTH, HJ DAS, GC PIATIGORSKY, J TI STRUCTURE, REGULATORY ELEMENTS AND PUTATIVE TRANSCRIPTION FACTORS OF THE CHICKEN BETA-B1-CRYSTALLIN GENE SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,MOLEC & DEV BIOL LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 968 EP 968 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201477 ER PT J AU CHAMBERS, C RUSSELL, P AF CHAMBERS, C RUSSELL, P TI DELETION MUTATION OF A LENS BETA-CRYSTALLIN - AN ANIMAL-MODEL FOR INHERITED CATARACTS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 969 EP 969 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201478 ER PT J AU PIATIGORSKY, J HORWITZ, J NORMAN, B AF PIATIGORSKY, J HORWITZ, J NORMAN, B TI THE J1-CRYSTALLIN GENE OF CUBAMEDUSAN JELLYFISH SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. JULES STEIN INST,LOS ANGELES,CA 90024. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 969 EP 969 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201482 ER PT J AU TOMAREV, S ZINOVIEVA, R PIATIGORSKY, J AF TOMAREV, S ZINOVIEVA, R PIATIGORSKY, J TI STRUCTURE AND LENS-PREFERRED EXPRESSION OF CRYSTALLIN GENES OF CEPHALOPODS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,MOLEC & DEV BIOL LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 969 EP 969 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201481 ER PT J AU RUSSELL, P AF RUSSELL, P TI 2-DIMENSIONAL GEL-ELECTROPHORESIS OF MONKEY AND HUMAN LENS EPITHELIA SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 970 EP 970 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201483 ER PT J AU CARPER, DA OLD, SE SATO, S KADOR, PF AF CARPER, DA OLD, SE SATO, S KADOR, PF TI CHARACTERIZATION OF RECOMBINANT HUMAN PLACENTA AND RAT LENS ALDOSE REDUCTASE EXPRESSED IN ESCHERICHIA-COLI SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. NR 1 TC 1 Z9 1 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 975 EP 975 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201510 ER PT J AU DUBIN, R SRIVASTAVA, R WAWROUSEK, E PIATIGORSKY, J AF DUBIN, R SRIVASTAVA, R WAWROUSEK, E PIATIGORSKY, J TI REGULATION OF ALPHA-B-CRYSTALLIN GENE-EXPRESSION SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. SMITHKLEIN BEECHAM,KING OF PRUSSIA,PA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 975 EP 975 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201512 ER PT J AU MCDERMOTT, JB PETERSON, CA PIATIGORSKY, J AF MCDERMOTT, JB PETERSON, CA PIATIGORSKY, J TI STRUCTURE AND TRANSCRIPTIONAL REGULATION OF THE CHICKEN ALPHA-A3/AL-CRYSTALLIN GENE SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,MOLEC & DEV BIOL LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 975 EP 975 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201511 ER PT J AU USUKURA, J BREITMAN, M ABE, T SHINOHARA, T AF USUKURA, J BREITMAN, M ABE, T SHINOHARA, T TI GENETIC ABLATION OF ROD PHOTORECEPTOR CELLS IN TRANSGENIC MICE - A NEW MODEL FOR THE RETINAL DEGENERATION SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NAGOYA UNIV, SCH MED, DEPT ANAT, NAGOYA, AICHI 466, JAPAN. MT SINAI HOSP, DIV MOLEC & DEV BIOL, TORONTO M5G 1X5, ONTARIO, CANADA. NEI, LRCMB, BETHESDA, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC PI ROCKVILLE PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA SN 0146-0404 EI 1552-5783 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 984 EP 984 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201552 ER PT J AU ABE, T ABE, T KIKUCHI, T SHINOHARA, T AF ABE, T ABE, T KIKUCHI, T SHINOHARA, T TI STRUCTURAL-ANALYSIS OF GENES ENCODED FOR HUMAN AND MOUSE 33KDA PROTEIN (PHOSDUCIN OR MEKA) SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI, RETINAL CELL & MOLEC BIOL LAB, BETHESDA, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC PI ROCKVILLE PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1006 EP 1006 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201664 ER PT J AU DANCIGER, M KOZAK, CA ABE, T SUZUKI, S SHINOHARA, T FARBER, DB AF DANCIGER, M KOZAK, CA ABE, T SUZUKI, S SHINOHARA, T FARBER, DB TI MAPPING OF THE GENES FOR 2 ROD PHOTORECEPTOR PROTEINS OF UNKNOWN FUNCTION IN THE MOUSE - THE 33 KDA PROTEIN AND THE 24 KDA PROTEIN SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 UNIV CALIF LOS ANGELES,SCH MED,JULES STEIN EYE INST,LOS ANGELES,CA 90024. LOYOLA MARYMOUNT UNIV,LOS ANGELES,CA 90045. NIAID,BETHESDA,MD 20892. NEI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1006 EP 1006 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201665 ER PT J AU KIKUCHI, T BREITMAN, M SHINOHARA, T AF KIKUCHI, T BREITMAN, M SHINOHARA, T TI REGULATION OF S-ANTIGEN - CHARACTERIZATION OF PROMOTER ACTIVITY INVITRO AND IN TRANSGENIC MICE SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI, RETINAL CELL & MOLEC BIOL LAB, BETHESDA, MD 20892 USA. MT SINAI HOSP, DIV MOLEC & DEV BIOL, TORONTO M5G 1X5, ONTARIO, CANADA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC PI ROCKVILLE PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA SN 0146-0404 EI 1552-5783 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1007 EP 1007 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201666 ER PT J AU SHINOHARA, T TSUDA, M BREITMAN, ML ZUCCONI, A KHOO, W USUKURA, J KIKUCHI, T SEKI, T AF SHINOHARA, T TSUDA, M BREITMAN, ML ZUCCONI, A KHOO, W USUKURA, J KIKUCHI, T SEKI, T TI THE 5'-FLANKING SEQUENCE OF S-ANTIGEN DIRECT EXPRESSION OF THE CAT GENE IN S-ANTIGEN-PRODUCING CELLS OF THE RETINA, PINEAL-GLAND, LENS AND BRAIN IN TRANSGENIC MICE SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI, RETINAL CELL & MOLEC BIOL LAB, BETHESDA, MD 20892 USA. MT SINAI HOSP, DIV MOLEC & DEV BIOL, TORONTO M5G 1X5, ONTARIO, CANADA. NAGOYA UNIV, SCH MED, DEPT ANAT, NAGOYA, AICHI 466, JAPAN. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC PI ROCKVILLE PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA SN 0146-0404 EI 1552-5783 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1007 EP 1007 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201667 ER PT J AU BORST, DE SI, JS NICKERSON, JM AF BORST, DE SI, JS NICKERSON, JM TI THE MOUSE IRBP PROMOTER - FUNCTIONAL ASSAYS FOR ACTIVITY SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,RETINAL CELL & MOLEC BIOL LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1011 EP 1011 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201688 ER PT J AU HAMEL, CP TSILOU, ET DETRICK, B HOOKS, JJ REDMOND, TM AF HAMEL, CP TSILOU, ET DETRICK, B HOOKS, JJ REDMOND, TM TI A MEMBRANE-ASSOCIATED RPE PROTEIN RELATED TO THE INTERMEDIATE FILAMENT FAMILY SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1012 EP 1012 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201696 ER PT J AU KIM, RY WISTOW, GJ AF KIM, RY WISTOW, GJ TI CDNA CLONING OF A MESSENGER-RNA EXPRESSED PREFERENTIALLY IN BOVINE RETINAL-PIGMENT EPITHELIUM SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,MOLEC DEV BIOL LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1013 EP 1013 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201697 ER PT J AU PUTILINA, T SMITH, S GENTLEMAN, S CHADER, GJ AF PUTILINA, T SMITH, S GENTLEMAN, S CHADER, GJ TI SYNTHESIS OF DEVELOPMENTALLY-ENHANCED LIBRARIES FROM MOUSE RETINA SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,RETINAL CELL & MOLEC BIOL LAB,BETHESDA,MD 20892. NR 2 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1013 EP 1013 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201699 ER PT J AU KADOR, PF TAKAHASHI, Y AUGUSTIN, W WYMAN, M AF KADOR, PF TAKAHASHI, Y AUGUSTIN, W WYMAN, M TI QUANTITATION OF RETINAL VESSEL CHANGES ASSOCIATED WITH DIABETIC-RETINOPATHY IN GALACTOSE-FED DOGS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. OHIO STATE UNIV,COLL VET MED,COLUMBUS,OH 43210. NR 1 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1028 EP 1028 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201771 ER PT J AU WALDBILLIG, RJ HEIDERSBACH, S JONES, BE DEJUAN, E VANKUIJK, F BITAR, M KADOR, P CHADER, GJ AF WALDBILLIG, RJ HEIDERSBACH, S JONES, BE DEJUAN, E VANKUIJK, F BITAR, M KADOR, P CHADER, GJ TI DIABETIC-RETINOPATHY IS ASSOCIATED WITH DISTURBED LEVELS OF VITREAL INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEIN SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. UNIV N CAROLINA,DEPT OPHTHALMOL,CHAPEL HILL,NC 27514. UNIV PENN,COLL PODIATR MED,PHILADELPHIA,PA 19104. MONTANA STATE UNIV,DEPT CHEM,BOZEMAN,MT 59717. NR 0 TC 2 Z9 2 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1028 EP 1028 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201767 ER PT J AU ESKANDAR, EN RICHMOND, BJ OPTICAN, LM AF ESKANDAR, EN RICHMOND, BJ OPTICAN, LM TI ROLE OF INFERIOR TEMPORAL NEURONS IN VISUAL-PATTERN RECOGNITION .1. TEMPORAL ENCODING OF CURRENT AND RECALLED INFORMATION SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NIMH,BETHESDA,MD 20892. NEI,LSR,BETHESDA,MD 20892. NR 0 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1036 EP 1036 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201811 ER PT J AU OPTICAN, LM RICHMOND, BJ ESKANDAR, EN AF OPTICAN, LM RICHMOND, BJ ESKANDAR, EN TI ROLE OF INFERIOR TEMPORAL NEURONS IN VISUAL-PATTERN RECOGNITION .2. TEMPORAL CORRELATION OF CURRENT AND RECALLED INFORMATION SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,LSR,BETHESDA,MD 20892. NIMH,BETHESDA,MD 20892. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1036 EP 1036 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201812 ER PT J AU SATO, Y BERKOWITZ, BA WILSON, CA DEJUAN, E AF SATO, Y BERKOWITZ, BA WILSON, CA DEJUAN, E TI A NEW TECHNIQUE FOR INVESTIGATING BREAKDOWN OF BLOOD-OCULAR BARRIER IN THE RABBIT EYE SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 DUKE UNIV,CTR EYE,DURHAM,NC 27706. NIEHS,RTP,RES TRIANGLE PK,NC 27709. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1048 EP 1048 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201865 ER PT J AU WILSON, CA BERKOWITZ, BA HATCHELL, DL AF WILSON, CA BERKOWITZ, BA HATCHELL, DL TI A NEW METHOD FOR MEASURING LOCALIZED INTRAOCULAR OXYGEN-TENSION - F-19 NMR OF LIQUID PERFLUOROCARBON BUBBLES SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 DUKE UNIV,CTR EYE,DURHAM,NC 27706. NIEHS,RTP,RES TRIANGLE PK,NC 27709. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1048 EP 1048 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201867 ER PT J AU SIMONS, BD FLYNN, HW FERRIS, FL CHEW, EY AF SIMONS, BD FLYNN, HW FERRIS, FL CHEW, EY TI PARS-PLANA VITRECTOMY IN THE EARLY TREATMENT DIABETIC-RETINOPATHY STUDY (ETDRS) SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 BROWN UNIV,PROVIDENCE,RI 02912. BASCOM PALMER EYE INST,MIAMI,FL. NEI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1050 EP 1050 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201872 ER PT J AU MORRISON, DF OBRIEN, PJ PEPPERBERG, DR AF MORRISON, DF OBRIEN, PJ PEPPERBERG, DR TI FUNCTIONAL-PROPERTIES OF DEPALMITYLATED RHODOPSIN SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 UNIV ILLINOIS,DEPT OPHTHALMOL,CHICAGO,IL 60680. NEI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1052 EP 1052 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201882 ER PT J AU ANANT, JS ONO, OC OBRIEN, PJ FUNG, BKK AF ANANT, JS ONO, OC OBRIEN, PJ FUNG, BKK TI INVIVO ISOPRENYLATION OF RETINAL CYCLIC-GMP PHOSPHODIESTERASE SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 UNIV CALIF LOS ANGELES,SCH MED,JULES STEIN EYE INST,LOS ANGELES,CA 90024. NEI,RETINAL CELL & MOLEC BIOL LAB,BETHESDA,MD 20892. NR 1 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1053 EP 1053 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201886 ER PT J AU RAO, CM AF RAO, CM TI SYNCHRONOUS SCAN FLUORESCENCE - A NOVEL-APPROACH TO STUDY CRYSTALLINS AND LENS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,MECHAN OCULAR DIS LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1058 EP 1058 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201911 ER PT J AU RAO, PV KRISHNA, CM ZIGLER, JS AF RAO, PV KRISHNA, CM ZIGLER, JS TI ZETA-CRYSTALLIN IS A NOVEL NADPH-QUINONE (ACCEPTOR) OXIDOREDUCTASE SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. NCI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1059 EP 1059 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76201918 ER PT J AU BANKIEWICZ, MA CARUSO, RC DATILES, MB VIVINO, MA KAISERKUPFER, MI AF BANKIEWICZ, MA CARUSO, RC DATILES, MB VIVINO, MA KAISERKUPFER, MI TI CONTRAST SENSITIVITY IN PATIENTS WITH NUCLEAR CATARACTS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,CLIN SERV BRANCH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1084 EP 1084 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76202041 ER PT J AU KUTTY, RK KUTTY, G HAYDEN, BJ WIGGERT, B CHADER, GJ AF KUTTY, RK KUTTY, G HAYDEN, BJ WIGGERT, B CHADER, GJ TI IMMUNOCHEMICAL DETECTION OF HEME OXYGENASE-1 (HO-1) IN RETINA AND Y-79 RETINOBLASTOMA CELLS - INDUCTION BY OXIDATIVE STRESS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NHLBI,BETHESDA,MD 20892. NEI,BETHESDA,MD 20892. NR 1 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1099 EP 1099 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76202108 ER PT J AU HESS, HH ZIGLER SAMUEL, J AF HESS, HH ZIGLER SAMUEL, J TI RETINA-LENS INTERACTION IN THE GENESIS OF CATARACTS IN RCS RATS AND PREVENTION BY DIETARY-SUPPLEMENTS OF ANTIOXIDANTS, INCLUDING BETA-CAROTENE AND VITAMIN-E SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1100 EP 1100 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76202117 ER PT J AU SAI, S USUKURA, J SHINOHARA, T WAKABAYASHI, T AWAYA, S AF SAI, S USUKURA, J SHINOHARA, T WAKABAYASHI, T AWAYA, S TI S-ANTIGEN LOCALIZATION IN THE DEVELOPING RDS MOUSE RETINA SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NAGOYA UNIV,DEPT OPHTHALMOL,NAGOYA,AICHI 464,JAPAN. NAGOYA UNIV,DEPT ANAT,NAGOYA,AICHI 464,JAPAN. NEI,BETHESDA,MD 20982. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1134 EP 1134 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76202281 ER PT J AU GENTLEMAN, S LLOYD, R PUTILINA, T CHADER, GJ AF GENTLEMAN, S LLOYD, R PUTILINA, T CHADER, GJ TI SIMILARITY OF ACETYLATED ALPHA-TUBULIN OF RETINA AND SPERM SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,RETINAL CELL & MOLEC BIOL LAB,BETHESDA,MD 20892. NR 3 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1136 EP 1136 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76202292 ER PT J AU PENG, YW RHEE, SG YAU, KW AF PENG, YW RHEE, SG YAU, KW TI LOCALIZATION OF PHOSPHOLIPASE-C ISOZYMES IN VERTEBRATE RETINA SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract ID BRAIN C1 JOHNS HOPKINS UNIV,SCH MED,HOWARD HUGHES MED INST,BALTIMORE,MD 21205. JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21205. NHLBI,BIOCHEM LAB,BETHESDA,MD 20892. NR 3 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1149 EP 1149 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76202356 ER PT J AU FLIESLER, SJ ARAKAWA, H OBRIEN, PJ AGUIRRE, GD ACLAND, GM AF FLIESLER, SJ ARAKAWA, H OBRIEN, PJ AGUIRRE, GD ACLAND, GM TI STRUCTURE OF FUCOSYLATED OLIGOSACCHARIDES OF ELKHOUND RHODOPSIN SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 UNIV PENN,SCH VET MED,MED GENET SECT,PHILADELPHIA,PA 19104. ST LOUIS UNIV,SCH MED,BETHESDA EYE INST,ST LOUIS,MO 63104. NEI,BETHESDA,MD 20892. UNIV PENN,SCHEIE EYE INST,SCH MED,PHILADELPHIA,PA 19104. NR 0 TC 3 Z9 3 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1150 EP 1150 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76202366 ER PT J AU DASGUPTA, S CARPER, D LIN, LR REDDY, VN AF DASGUPTA, S CARPER, D LIN, LR REDDY, VN TI HYPERTONIC STRESS INCREASES ALDOSE REDUCTASE, MYOINOSITOL AND FREE AMINO-ACIDS IN PRIMARY CULTURES OF HUMAN LENS EPITHELIAL-CELLS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. OAKLAND UNIV,EYE RES INST,ROCHESTER,MI 48063. NR 2 TC 1 Z9 1 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1156 EP 1156 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76202390 ER PT J AU KARINO, K BALABAN, R KADOR, PF AF KARINO, K BALABAN, R KADOR, PF TI COMPARISON OF NADPH-DEPENDENT REDUCTASE-ACTIVITY IN THE LENS AND RED-BLOOD-CELL BY F-19 NMR-SPECTROSCOPY WITH 3-DEOXY-3-FLUOROGLUCOSE SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. NHLBI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1157 EP 1157 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76202392 ER PT J AU ZIGLER, JS RAO, P AF ZIGLER, JS RAO, P TI QUINONE INDUCED STIMULATION OF HEXOSE-MONOPHOSPHATE SHUNT ACTIVITY IN THE GUINEA-PIG LENS IN CULTURE - ROLE OF ZETA-CRYSTALLIN SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1157 EP 1157 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76202394 ER PT J AU HWANG, DG NAKAMURA, T HUANG, CM TROUSDALE, MD CHEN, HC AF HWANG, DG NAKAMURA, T HUANG, CM TROUSDALE, MD CHEN, HC TI EFFICACY OF A SYNTHETIC MAGAININ ANALOG AGAINST TROPHOZOITES AND CYSTS OF ACANTHAMOEBA SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 UNIV CALIF SAN FRANCISCO,DEPT OPHTHALMOL,SAN FRANCISCO,CA 94143. UNIV SO CALIF,DOHENY EYE INST,DEPT OPHTHALMOL,LOS ANGELES,CA 90089. THOMAS JEFFERSON UNIV,DEPT PATHOL,PHILADELPHIA,PA 19107. NICHHD,BETHESDA,MD 20892. NR 1 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1182 EP 1182 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76202517 ER PT J AU WAKEFIELD, D CHAN, CC MCCLUSKEY, P LI, Q NUSSENBLATT, RB AF WAKEFIELD, D CHAN, CC MCCLUSKEY, P LI, Q NUSSENBLATT, RB TI EXPRESSION OF INTERFERON-GAMMA AND DEFENSINS IN UVEITIS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 UNIV NEW S WALES,OCULAR IMMUNOL LAB,SYDNEY,NSW,AUSTRALIA. NEI,BETHESDA,MD 20892. RI McCluskey, Peter/H-7607-2013 OI McCluskey, Peter/0000-0002-8177-1637 NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1186 EP 1186 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76202537 ER PT J AU FLETCHER, RT BOJE, KM SKOLNICK, P RABER, J CHADER, GJ AF FLETCHER, RT BOJE, KM SKOLNICK, P RABER, J CHADER, GJ TI 1-AMINOCYCLOPROPANECARBOXYLIC ACID (ACPC) ATTENUATES NMDA EXCITOTOXICITY IN EMBRYONIC CHICK RETINA SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. NIDDK,BETHESDA,MD. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1189 EP 1189 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76202548 ER PT J AU PINEDA, R JOHNSON, MA TOMBRANTINK, J LI, AR CHADER, GJ AF PINEDA, R JOHNSON, MA TOMBRANTINK, J LI, AR CHADER, GJ TI DIFFERENTIATION INDUCED BY CYCLIC-AMP IS REVERSIBLE IN HUMAN Y79 RETINOBLASTOMA CELLS-INVITRO SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,RETINAL CELL & MOLEC BIOL LAB,BETHESDA,MD 20892. HOWARD HUGHES MED INST,BETHESDA,MD. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1198 EP 1198 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76202593 ER PT J AU RAJAGOPALAN, S RODRIGUES, M ADVANI, SH NAIR, CN DONOSO, L WIGGERT, B LEE, L KUTTY, G CHADER, GJ AF RAJAGOPALAN, S RODRIGUES, M ADVANI, SH NAIR, CN DONOSO, L WIGGERT, B LEE, L KUTTY, G CHADER, GJ TI DIFFERENTIATION IN RETINOBLASTOMA SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 UNIV MARYLAND,DEPT OPHTHALMOL,OPHTHALMM PATHOL LAB,BALTIMORE,MD 21201. TATA MEM HOSP,DEPT MED ONCOL,BOMBAY,INDIA. WILLS EYE HOSP & RES INST,PHILADELPHIA,PA 19107. NEI,RETINAL CELL & MOLEC BIOL LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1198 EP 1198 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76202596 ER PT J AU YAMADA, T RUSSELL, P AF YAMADA, T RUSSELL, P TI INSITU LOCALIZATION OF MESSENGER-RNA FOR BETA-B2-CRYSTALLIN IN NORMAL AND PHILLY MOUSE LENS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 TOHOKU UNIV,SCH MED,DEPT OPHTHALMOL,SENDAI,MIYAGI 980,JAPAN. NEI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1207 EP 1207 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76202636 ER PT J AU PFEFFER, BA KIRCHOFFREMPE, M GUERIN, CJ MATSUMOTO, B ANDERSON, DH HAGEMAN, GS AF PFEFFER, BA KIRCHOFFREMPE, M GUERIN, CJ MATSUMOTO, B ANDERSON, DH HAGEMAN, GS TI RPE CONTRIBUTION TO PRIMATE INTERPHOTORECEPTOR MATRIX, ASSESSED BY ANALYSIS OF PROTEINS BIOSYNTHETICALLY LABELED INSITU AND INVITRO SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 BETHESDA EYE INST,ST LOUIS,MO. NEI,BETHESDA,MD 20892. UNIV CALIF SANTA BARBARA,INST NEUROSCI,SANTA BARBARA,CA 93106. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1217 EP 1217 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76202683 ER PT J AU LIN, LR CHAKRAPANI, B YOKOYAMA, T REDDY, VN DASGUPTA, S CARPER, D AF LIN, LR CHAKRAPANI, B YOKOYAMA, T REDDY, VN DASGUPTA, S CARPER, D TI INDUCTION OF ALDOSE REDUCTASE, ALPHAB CRYSTALLIN AND ORGANIC SOLUTES IN PRIMARY CULTURES OF HUMAN RETINAL-PIGMENT EPITHELIUM BY HYPERTONIC STRESS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 OAKLAND UNIV,EYE RES INST,ROCHESTER,MI 48063. NEI,BETHESDA,MD 20892. NR 2 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1220 EP 1220 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76202702 ER PT J AU LOPEZ, JS DESMET, MD THURAU, SR HERBORT, CP LORBERBOUMGALSKI, H PASTAN, CCCI NUSSENBLATT, RB AF LOPEZ, JS DESMET, MD THURAU, SR HERBORT, CP LORBERBOUMGALSKI, H PASTAN, CCCI NUSSENBLATT, RB TI USE OF IL2-PE-40 VIA THE PERI-OCULAR ROUTE IN CORNEAL GRAFT-REJECTION MODEL IN LEWIS RATS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. NIH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1237 EP 1237 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76202783 ER PT J AU MILTON, RC SPERDUTO, RD AF MILTON, RC SPERDUTO, RD TI INCIDENCE OF AGE-RELATED CATARACT - 13.6-YEAR FOLLOW-UP IN THE FRAMINGHAM EYE STUDY SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. FRAMINGHAM EYE STUDY GRP,FRAMINGHAM,MA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1243 EP 1243 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76202817 ER PT J AU MAGNO, BV DATILES, MB SPERDUTO, R PODGOR, M LASA, MSM LEE, J AF MAGNO, BV DATILES, MB SPERDUTO, R PODGOR, M LASA, MSM LEE, J TI CATARACT PROGRESSION RATES USING THE LENS OPACITY CLASSIFICATION SYSTEM-II SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. NR 0 TC 1 Z9 1 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1244 EP 1244 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76202822 ER PT J AU LASA, MSM DATILES, MB PODGOR, M MAGNO, BV LEE, J AF LASA, MSM DATILES, MB PODGOR, M MAGNO, BV LEE, J TI CONTRAST AND GLARE SENSITIVITY - ASSOCIATION WITH THE TYPE AND SEVERITY OF THE CATARACT SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1245 EP 1245 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76202828 ER PT J AU HAZARD, ES CROUCH, RK CHADER, G WIGGERT, B AF HAZARD, ES CROUCH, RK CHADER, G WIGGERT, B TI IRBP LIGANDS - EVIDENCE FOR POSSIBLE COMPETITION BETWEEN ALL-TRANS RETINOL AND PALMITIC ACID SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 MED UNIV S CAROLINA,CHARLESTON,SC 29425. NEI,BETHESDA,MD 20892. NR 1 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1250 EP 1250 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76202853 ER PT J AU KUTTY, G CHADER, GJ WIGGERT, B AF KUTTY, G CHADER, GJ WIGGERT, B TI A RETINOID-BINDING GLYCOPROTEIN SIMILAR TO IRBP IS PRESENT IN DROSOPHILA-MELANOGASTER SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NIH,BETHESDA,MD 20892. NR 0 TC 1 Z9 1 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1250 EP 1250 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76202855 ER PT J AU REDMOND, TM HUMAYUN, M CHADER, GJ NICKERSON, JM AF REDMOND, TM HUMAYUN, M CHADER, GJ NICKERSON, JM TI RETINOID BINDING TO IRBP - IS HALF A LOAF BETTER THAN NONE AT ALL SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. NR 0 TC 1 Z9 1 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1250 EP 1250 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76202854 ER PT J AU NICKERSON, JM BORST, DE SAPERSTEIN, DA SI, JS AF NICKERSON, JM BORST, DE SAPERSTEIN, DA SI, JS TI CIS-ELEMENTS AND TRANS-FACTORS IN THE IRBP GENE AND STRUCTURAL DOMAINS IN THE IRBP PROTEIN REPEAT SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,LRCMB,BETHESDA,MD 20892. ST LOUIS UNIV,BETHESDA EYE INST,ST LOUIS,MO 63103. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1251 EP 1251 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76202857 ER PT J AU STEELE, FR NICKERSON, JM AF STEELE, FR NICKERSON, JM TI ISOLATION OF CDNAS FROM A DROSOPHILA-MELANOGASTER HEAD-SPECIFIC CDNA LIBRARY WITH HOMOLOGY TO VERTEBRATE IRBP SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,LRCMB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1251 EP 1251 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76202856 ER PT J AU CHANG, T SUZUKI, S TSUDA, M DETRICK, B HOOKS, J SHINOHARA, T AF CHANG, T SUZUKI, S TSUDA, M DETRICK, B HOOKS, J SHINOHARA, T TI ANALYSIS OF THE HUMAN AND BOVINE 24 KDA-PROTEIN - CDNA AND GENE IN THE RETINAL PHOTORECEPTOR CELLS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,RETINAL CELL & MOLEC BIOL LAB,BETHESDA,MD 20892. NEI,IMMUNOL LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1258 EP 1258 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76202888 ER PT J AU TAKAHASHI, Y WYMAN, M RABER, J FERRIS, F KADOR, PF AF TAKAHASHI, Y WYMAN, M RABER, J FERRIS, F KADOR, PF TI RETINAL VESSEL CHANGES ASSOCIATED WITH ADVANCED DIABETIC-RETINOPATHY IN GALACTOSE-FED DOGS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. OHIO STATE UNIV,COLL VET MED,COLUMBUS,OH 43210. NR 1 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1288 EP 1288 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76203040 ER PT J AU SCHOEN, TJ WALDBILLIG, RJ BEEBE, DC CLEMMONS, DR CHADER, GJ AF SCHOEN, TJ WALDBILLIG, RJ BEEBE, DC CLEMMONS, DR CHADER, GJ TI DIFFERENTIAL REGULATION OF VITREAL AND SERUM INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEINS (IGF-BP) IN DEVELOPING CHICKEN SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. UNIFORMED SERV UNIV HLTH SCI,DEPT ANAT & CELL BIOL,BETHESDA,MD 20814. UNIV N CAROLINA,SCH MED,DIV ENDOCRINOL,CHAPEL HILL,NC 27514. NR 0 TC 1 Z9 1 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1303 EP 1303 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76203114 ER PT J AU BAREZ, S BOUMPAS, DT PERCOPO, CM ANASTASSIOU, ED HOOKS, JJ DETRICK, B AF BAREZ, S BOUMPAS, DT PERCOPO, CM ANASTASSIOU, ED HOOKS, JJ DETRICK, B TI MODULATION OF MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) CLASS-I GENES IN HUMAN RETINOBLASTOMA CELLS BY INTERFERONS - EVIDENCE FOR TRANSCRIPTIONAL AND POSTTRANSCRIPTIONAL REGULATION SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NIDDK,BETHESDA,MD. NEI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1305 EP 1305 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76203127 ER PT J AU HAYDEN, BJ GAUDET, S CHADER, GJ NAMBOODIRI, MAA AF HAYDEN, BJ GAUDET, S CHADER, GJ NAMBOODIRI, MAA TI DIFFERENTIAL MODULATION OF ARYLALKYLAMINE AND ARYLAMINE N-ACETYLTRANSFERASE ACTIVITIES IN Y-79 RETINOBLASTOMA CELLS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,BETHESDA,MD 20892. GEORGETOWN UNIV,DEPT BIOL,WASHINGTON,DC 20057. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1305 EP 1305 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76203124 ER PT J AU JOHNSON, MA TOMBRANTINK, J JOHNSON, LV CHADER, GJ AF JOHNSON, MA TOMBRANTINK, J JOHNSON, LV CHADER, GJ TI NEUROFILAMENT PROTEIN (NF) - A MARKER FOR NEURONAL MATURITY IN HUMAN Y79 RETINOBLASTOMA CELLS-INVITRO SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 HOWARD HUGHES MED INST,BETHESDA,MD. NEI,LRCMB,BETHESDA,MD 20892. UNIV SO CALIF,SCH MED,LOS ANGELES,CA 90033. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 1305 EP 1305 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76203126 ER PT J AU BURGESS, GM BIRD, GSJ OBIE, JF PUTNEY, JW AF BURGESS, GM BIRD, GSJ OBIE, JF PUTNEY, JW TI THE MECHANISM FOR SYNERGISM BETWEEN PHOSPHOLIPASE-C-LINKED AND ADENYLYLCYCLASE-LINKED HORMONES IN LIVER - CYCLIC AMP-DEPENDENT KINASE AUGMENTS INOSITOL TRISPHOSPHATE-MEDIATED CA2+ MOBILIZATION WITHOUT INCREASING THE CELLULAR-LEVELS OF INOSITOL POLYPHOSPHATES SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID GUINEA-PIG HEPATOCYTES; CYTOSOLIC CALCIUM; 1,4,5-TRISPHOSPHATE RECEPTOR; FURA-2-LOADED HEPATOCYTES; STIMULATED HEPATOCYTES; RAT HEPATOCYTES; RELEASE; CELLS; CAMP; VASOPRESSIN AB The ability of cAMP-dependent hormones to modulate the actions of Ca2+-mobilizing hormones was studied in single fura-2-injected guinea pig hepatocytes. In 91% of cells the cAMP-linked hormone, isoproterenol, applied alone, did not alter cytosolic Ca2+ concentration. In 78% of cells which had been pre-exposed to a low concentration of angiotensin II, isoproterenol was able to increase cytosolic Ca2+. Isoproterenol did not, however, increase inositol 1,4,5-trisphosphate or inositol tetrakisphosphate on its own, or in the presence of angiotensin II. Isoproterenol was also able to raise cytosolic Ca2+ concentration in cells microinjected with inositol 2,4,5-triphosphate or a photoactivatable derivative of inositol 1,4,5-trisphosphate. The elevation of cytosolic Ca2+ concentration induced by isoproterenol in angiotensin II-treated cells and cells injected with caged inositol 1,4,5-trisphosphate was blocked by heparin, implying that the effect was mediated by an inositol 1,4,5-trisphosphate receptor agonist. In permeabilized hepatocytes, inositol 1,4,5-trisphosphate-induced Ca2+ release was enhanced by 8-bromo-cAMP and the catalytic subunit of cAMP-dependent kinase. Cyclic AMP-dependent kinase shifted the dose-response curve for inositol 1,4,5-trisphosphate-mediated Ca2+ release to the left by a factor of 4 and increased the total amount of Ca2+ released by 25%. These results indicate that increased sensitivity of the intracellular Ca2+ releasing organelle to inositol 1,4,5-trisphosphate is responsible for synergism between phospholipase C- and adenylylcyclase-linked hormones in the liver. C1 SANDOZ INST MED RES,LONDON WC1E 6BN,ENGLAND. RP BURGESS, GM (reprint author), NATL INST ENVIRONM HLTH,CALCIUM REGULAT SECT,CELLULAR & MOLEC PHARMACOL LAB,RES TRIANGLE PK,NC 27709, USA. NR 38 TC 164 Z9 164 U1 0 U2 0 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD MAR 15 PY 1991 VL 266 IS 8 BP 4772 EP 4781 PG 10 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA FC217 UT WOS:A1991FC21700019 PM 1848225 ER PT J AU BIZUB, D WEBER, IT CAMERON, CE LEIS, JP SKALKA, AM AF BIZUB, D WEBER, IT CAMERON, CE LEIS, JP SKALKA, AM TI A RANGE OF CATALYTIC EFFICIENCIES WITH AVIAN RETROVIRAL PROTEASE SUBUNITS GENETICALLY LINKED TO FORM SINGLE POLYPEPTIDE-CHAINS SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID ESCHERICHIA-COLI; HIV-1 PROTEASE; GENE-PRODUCTS; MUTAGENESIS; PROTEINS; DNA AB Molecular modeling based on the crystal structure of the Rous sarcoma virus (RSV) protease dimer has been used to link the two identical subunits of this enzyme into a functional, single polypeptide chain resembling the nonviral aspartic proteases. Six different linkages were selected to test the importance of different interactions between the amino acids at the amino and carboxyl termini of the two subunits. These linkages were introduced into molecular clones of fused protease genes and the linked protease dimers were expressed in Escherichia coli and purified. Catalytically active proteins were obtained from the inclusion body fraction after renaturation. The linked protease dimers exhibited a 10-20-fold range in catalytic efficiencies (V(max)/K(m)) on peptide substrates. Both flexibility and ionic interactions in the linkage region affect catalytic efficiency. Some of the linked protease dimers were 2-3-fold more active than the nonlinked enzyme purified from bacteria, although substrate specificities were unchanged. Similar relative efficiencies were observed using a polyprotein precursor as substrate. Mutation of one catalytic Asp in the most active linked protease dimer inactivated the enzyme, demonstrating that these proteins function as single polypeptide chains rather than as multimers. C1 FOX CHASE CANC INST,INST CANC RES,7701 BURKHOLME AVE,PHILADELPHIA,PA 19111. NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,FREDERICK,MD 21701. CASE WESTERN RESERVE UNIV,SCH MED,CLEVELAND,OH 44106. FU NCI NIH HHS [CA-48703, CA-49042]; NCRR NIH HHS [RR-05539] NR 27 TC 33 Z9 33 U1 0 U2 2 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD MAR 15 PY 1991 VL 266 IS 8 BP 4951 EP 4958 PG 8 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA FC217 UT WOS:A1991FC21700044 PM 1848230 ER PT J AU FLOYD, CC GRANT, P GALLANT, PE PANT, HC AF FLOYD, CC GRANT, P GALLANT, PE PANT, HC TI PRINCIPAL NEUROFILAMENT-ASSOCIATED PROTEIN-KINASE IN SQUID AXOPLASM IS RELATED TO CASEIN KINASE-I SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID AMINO-ACID SEQUENCE; PHOSPHORYLATION SITES; TRIPLET PROTEINS; GIANT-AXON; NF-M; PURIFICATION; POLYPEPTIDES; SUBUNIT; GENE; PROTEOLYSIS AB A cytoskeletal extract of pure axoplasm, highly enriched with neurofilaments (ANF), was prepared from the giant axon of the squid. This ANF preparation also contained potent kinase activities which phosphorylated the M(r) > 400,000 (high molecular weight) and M(r) 220,000 squid neurofilament protein subunits. High salt (1 M) extraction of this ANF preparation solubilized most of the neurofilament proteins and kinase activities and gel filtration on an AcA 44 column separated these two components. The neurofilaments eluted in the void volume of the column while the kinase activities eluted in the 17-44-kDa range of the column. Two major kinase activities were measured in this peak of activity. One of these strongly phosphorylated the phosphate acceptor peptide Leu-Arg-Arg-Ala-Ser-Leu-Gly (Kemptide) and was completely inhibited by selective inhibitor of cAMP-dependent kinase Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2 (Wiptide). Since addition of cAMP did not stimulate activity, this suggested that this kinase was a free catalytic subunit of cAMP-dependent kinase associated with the neurofilaments. The second kinase activity most effectively phosphorylated alpha-casein, and this activity was not affected by Wiptide. The alpha-casein phosphorylating activity (ANF kinase) was the principal activity responsible for neurofilament protein phosphorylation, and was not inhibited by various inhibitors against second messenger regulated kinases, suggesting it was related to the casein kinase family. Four lines of evidence indicate ANF kinase was similar to casein kinase I. These were: 1) the apparent molecular weight determined by gel filtration and the chromatographic elution profile on phosphocellulose column corresponded to casein kinase I; 2) heparin, an inhibitor of casein kinase II at 2-5-mu-g/ml, stimulated both ANF kinase and purified casein kinase I at these concentrations, while CKI-7, a relatively selective inhibitor of casein kinase I, inhibited ANF kinase in a comparable dose-response fashion; 3) purified casein kinase I strongly phosphorylated both ANF protein subunits (like ANF kinase) whereas casein kinase II was relatively ineffective; and 4) tryptic peptide maps of the HMW and M(r) 220,000 neurofilament proteins after phosphorylation by ANF kinase or purified casein kinase I showed similar P-32-peptide patterns. C1 NIH,NEUROBIOL LAB,BETHESDA,MD 20892. MARINE BIOL LAB,WOODS HOLE,MA 02543. RP FLOYD, CC (reprint author), NINCDS,NEUROCHEM LAB,BLDG 36,RM 4D20,BETHESDA,MD 20892, USA. NR 54 TC 48 Z9 48 U1 0 U2 0 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD MAR 15 PY 1991 VL 266 IS 8 BP 4987 EP 4994 PG 8 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA FC217 UT WOS:A1991FC21700049 PM 2002043 ER PT J AU JIN, FS YOULE, RJ JOHNSON, VG SHILOACH, J FASS, R LONGO, DL BRIDGES, SH AF JIN, FS YOULE, RJ JOHNSON, VG SHILOACH, J FASS, R LONGO, DL BRIDGES, SH TI SUPPRESSION OF THE IMMUNE-RESPONSE TO IMMUNOTOXINS WITH ANTI-CD4 MONOCLONAL-ANTIBODIES SO JOURNAL OF IMMUNOLOGY LA English DT Article ID MURINE TRANSFERRIN RECEPTOR; HAIRY-CELL LEUKEMIA; NUDE-MOUSE MODEL; TOLERANCE INDUCTION; ANTITUMOR-ACTIVITY; OVARIAN-CANCER; L3T4; RICIN; IMMUNOSUPPRESSION; INTERFERON AB Treatment of normal mice with a mAb to CD4 (GK1.5) was explored as a means of inhibiting the antibody response to an immunotoxin. Three days of pretreatment with 200-mu-g of GK1.5 completely abrogated the primary antibody response to a 3-mu-g dose of a mutant diphtheria toxin conjugated to an anti-transferrin receptor antibody. The same dose and schedule of anti-CD4 antibody significantly reduced and delayed, but did not prevent, the anamnestic antitoxin response in animals that had been previously primed to the immunotoxin. Three daily injections of anti-CD4 antibodies followed by weekly doses of immunotoxin resulted in a 3-wk delay in the development of antitoxin antibodies, and the kinetics of the antitoxin response correlated with the kinetics of recovery of CD4+ T cells in the spleen and lymph nodes. The antitoxin response to repeated doses of immunotoxin was completely abrogated when anti-CD4 antibodies were given every 2 wk throughout the course of immunotoxin treatment. Thus, transient depletion of Th cells during treatment can block the immune response to an immunotoxin. There was no evidence of tolerance induction with this regimen. C1 NIDDKD,CELLULAR & DEV BIOL LAB,BETHESDA,MD 20892. NCI,BIOL RESPONSE MODIFIERS PROGRAM,BETHESDA,MD 20892. NCI,BIOL RESPONSE MODIFIERS PROGRAM,FREDERICK,MD 21701. RP JIN, FS (reprint author), NINCDS,SURG NEUROL BRANCH,BETHESDA,MD 20892, USA. NR 25 TC 28 Z9 28 U1 0 U2 1 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD MAR 15 PY 1991 VL 146 IS 6 BP 1806 EP 1811 PG 6 WC Immunology SC Immunology GA FC439 UT WOS:A1991FC43900013 PM 1672333 ER PT J AU LIANG, SM LIANG, CM HARGROVE, ME TING, CC AF LIANG, SM LIANG, CM HARGROVE, ME TING, CC TI REGULATION BY GLUTATHIONE OF THE EFFECT OF LYMPHOKINES ON DIFFERENTIATION OF PRIMARY ACTIVATED LYMPHOCYTES - INFLUENCE OF GLUTATHIONE ON CYTOTOXIC ACTIVITY OF CD3-AK- SO JOURNAL OF IMMUNOLOGY LA English DT Article ID T-CELLS; 2-MERCAPTOETHANOL ACTS; MONOCLONAL-ANTIBODY; ANTI-T3 ANTIBODY; KILLER ACTIVITY; FRIEND VIRUS; PROLIFERATION; LEUKEMIA; INVITRO; GROWTH AB By activating murine lymphocytes with anti-CD3 antibodies for 1 to 2 days, we generated a subset of activated killer cells, namely CD3-AK-. CD3-AK- mediated the slow lysis (20-h I-125-UdR release assay) of allogeneic P815 but had little effect on syngeneic HFL/b cells. Addition of IL-2 (murine or human) or an IL-2 inducer such as PMA in the assay medium induced the cytolytic activity of CD3-AK- on HFL/b. The activating effect of murine IL-2 and PMA on CD3-AK- was decreased by anti-murine IL-2 mAb. Although anti-murine IL-4 mAb alone did not show any effect, it enhanced the inhibitory effect of anti-IL-2 mAb, suggesting that IL-2 and IL-4 may have a synergistic effect on the cytolytic activity of CD3-AK-. Incubation of CD3-AK- with L-buthionine-(SR)-sulfoximine (BSO), an inhibitor of de novo glutathione (GSH) synthesis, decreased cellular GSH levels and inhibited the cytolytic activity of CD3-AK-, in a concentration-dependent manner. This inhibitory effect of BSO was not primarily due to a general cytotoxic effect and was positively correlated with the requirement for IL-2 for the CD3-AK--mediated killing of the target cells. Incubation of CD3-AK- with GSH or 2-ME, which increased the level of cellular GSH, reversed the inhibitory effect of BSO. These results suggest that cellular GSH may regulate the effect of lymphokine(s) such as IL-2 and thus affect the differentiation of activated primary cytotoxic lymphocytes. C1 US FDA,CTR BIOL EVALUAT & RES,BETHESDA,MD 20892. NCI,DIV CELL BIOL & DIAG,BETHESDA,MD 20892. NR 33 TC 34 Z9 36 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD MAR 15 PY 1991 VL 146 IS 6 BP 1909 EP 1913 PG 5 WC Immunology SC Immunology GA FC439 UT WOS:A1991FC43900028 PM 1826013 ER PT J AU SMYTH, MJ AF SMYTH, MJ TI GLUTATHIONE MODULATES ACTIVATION-DEPENDENT PROLIFERATION OF HUMAN PERIPHERAL-BLOOD LYMPHOCYTE POPULATIONS WITHOUT REGULATING THEIR ACTIVATED FUNCTION SO JOURNAL OF IMMUNOLOGY LA English DT Article ID NATURAL-KILLER CELLS; P75 INTERLEUKIN-2 RECEPTOR; LARGE GRANULAR LYMPHOCYTES; T-CELLS; GAMMA PRODUCTION; 2-CYCLOHEXENE-1-ONE; INHIBITION; PERFORIN; IL-2; TRANSFORMATION AB L-Buthionine-(S,R)-sulfoximine (BSO) specifically depletes GSH synthesis by inactivating gamma-glutamyl-cysteine synthetase, whereas 2-ME augments intracellular GSH concentration. These reagents were used to examine GSH regulation of the proliferation and function of human PBL in response to IL-2 or OKT-3 mAb directed at the CD3 T cell Ag. 2-ME enhanced both IL-2-induced proliferation of PBL and CD3- large granular lymphocytes (LGL) and OKT-3 mAb-induced proliferation of CD3+ T cells. BSO partially suppressed activation-induced proliferation in CD3- LGL and CD3+ T cells and totally inhibited the positive co-proliferative regulation by 2-ME in these cells. By contrast, neither BSO nor 2-ME appeared to affect the activation-dependent differentiation of cytotoxic lymphocytes. The absence of effect of 2-ME or BSO on activation-induced PBL NK activity and T cell cytotoxic potential was supported by their negligible effect on the induction of two different markers of activated cytotoxic lymphocytes, namely pore-forming protein gene expression and benzoyloxycarbonyl-1-L-lysine thiobenzylester-esterase activity. BSO inhibition of CD3- LGL proliferation accounted for the inhibitory effects of BSO on both IFN-gamma production in IL-2-stimulated PBL cultures and IL-2-induced PBL lymphokine activated killer activity. The modulatory effects of 2-ME and BSO on lymphocyte proliferation regardless of phenotype (LGL vs T cell) or stimulation (IL-2, via CD3, lectin, etc.) and the functional differentiation of cytotoxic lymphocytes independent of proliferation suggests that these cells share a common site of GSH regulation close to or at the level of DNA synthesis. RP SMYTH, MJ (reprint author), NCI,FREDERICK CANC RES & DEV CTR,EXPTL IMMUNOL LAB,FREDERICK,MD 21701, USA. RI Smyth, Mark/H-8709-2014 OI Smyth, Mark/0000-0001-7098-7240 NR 42 TC 86 Z9 87 U1 0 U2 2 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD MAR 15 PY 1991 VL 146 IS 6 BP 1921 EP 1927 PG 7 WC Immunology SC Immunology GA FC439 UT WOS:A1991FC43900030 PM 2005386 ER PT J AU KARPATI, RM BANKS, SM MALISSEN, B ROSENBERG, SA SHEARD, MA WEBER, JS HODES, RJ AF KARPATI, RM BANKS, SM MALISSEN, B ROSENBERG, SA SHEARD, MA WEBER, JS HODES, RJ TI PHENOTYPIC CHARACTERIZATION OF MURINE TUMOR-INFILTRATING LYMPHOCYTES-T SO JOURNAL OF IMMUNOLOGY LA English DT Article ID SPONGE MATRIX ALLOGRAFTS; NATURAL-KILLER CELLS; MONOCLONAL-ANTIBODY; RECOMBINANT INTERLEUKIN-2; V-ALPHA; I-E; RECEPTOR; IMMUNOTHERAPY; ANTIGEN; RAT AB Tumor infiltrating lymphocytes (TIL) can be isolated from solid tumors and selectively expanded in long term culture with IL-2 and autologous irradiated tumor. Such long term cultured cells express anti-tumor activity in vitro, mediate the regression of established tumor in murine models of cancer, and have been used for the treatment of cancer in humans. We have characterized freshly isolated mouse Thy-1+ TIL populations, as well as long term TIL cultures, from several different C57BL/6 (B6) tumors. Freshly isolated Thy-1+ TIL include both CD4+ and CD8+ cells, as well as cells bearing NK markers. These cells are predominantly TCR alpha-beta+, with a smaller population of TCR gamma-delta+ cells. The TCR alpha-beta+ cells expressed a broad distribution of V-beta phenotypes that was statistically different from that expressed in normal B6 splenic Thy-1+ cells or CD8+ cells, presumably reflecting in vivo selection in the host anti-tumor response. NK cells are present in these tumors at a greater frequency than noted in splenic T cells. Cultured TIL populations rapidly became exclusively Thy-1+/CD8+/CD4- and TCR alpha-beta+/gamma-delta-. Individual long term TIL populations initially expressed multiple V-beta products, but rapidly restricted their V-beta expression, frequently expressing a single dominant V-beta. The identity of this dominant V-beta varied among different TIL lines, but the overall representation of V-beta phenotypes in these cultures was statistically different from that seen in Thy-1+ or CD8+ splenocytes. No statistical difference was noted between lines derived from antigenically distinct tumors. The selection of tumor specific T cells in vitro is therefore not reflected in any simple predominance of V-beta usage. The complexity of TCR usage in the anti-tumor response may result from the involvement of multiple alpha- and beta-chain regions in the response to a single antigenic determinant, or may reflect multiple antigenic determinants expressed on a single syngeneic tumor. C1 NCI,EXPTL IMMUNOL BRANCH,BETHESDA,MD 20892. NIAID,OFF SCI DIRECTOR,BETHESDA,MD 20892. NCI,SURG BRANCH,BETHESDA,MD 20892. CTR IMMUNOL MARSEILLE LUMINY,MARSEILLE,FRANCE. NR 49 TC 47 Z9 47 U1 1 U2 1 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD MAR 15 PY 1991 VL 146 IS 6 BP 2043 EP 2051 PG 9 WC Immunology SC Immunology GA FC439 UT WOS:A1991FC43900047 PM 1672340 ER PT J AU DOLLAR, AL ROBERTS, WC AF DOLLAR, AL ROBERTS, WC TI MORPHOLOGICAL COMPARISON OF PATIENTS WITH MITRAL-VALVE PROLAPSE WHO DIED SUDDENLY WITH PATIENTS WHO DIED FROM SEVERE VALVULAR DYSFUNCTION OR OTHER CONDITIONS SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Article ID LATE SYSTOLIC-MURMUR; POSTERIOR LEAFLET; FOLLOW-UP; DEATH; CLICK; COMPLICATIONS; ARRHYTHMIAS; PATHOLOGY; PROGNOSIS; FEATURES AB Clinical and necropsy findings are described in 56 patients with mitral valve prolapse: 15 patients, aged 16 to 69 years (mean 39), died suddenly and mitral valve prolapse was the only cardiac condition found at necropsy (hereafter called isolated mitral valve prolapse); the remaining 41 patients had other conditions that were capable of being fatal. Of the latter 41 patients, 7, aged 17 to 59 years (mean 45), had associated congenital heart disease, and 34 patients, aged 17 to 70 years (mean 52), had no associated congenital cardiac abnormalities. Compared with the 34 patients without associated congenital heart disease and with nonmitral valve prolapse conditions capable in themselves of being fatal, the 15 patients who died suddenly with isolated mitral valve prolapse were younger (mean age 39 +/- 17 versus 52 +/- 15 years; p = 0.01), more often women (67% versus 26%; p = 0.008) and had a lower frequency of mitral regurgitation (7% versus 38%; p = 0.02). The 15 patients dying suddenly with isolated mitral valve prolapse also were less likely to have evidence of ruptured chordae tendineae (29% versus 67%; p = 0.04). The frequency of increased heart weight (67% versus 59%), a dilated mitral valve anulus (80% versus 81%), a dilated tricuspid valve anulus (17% versus 17%), an elongated anterior mitral leaflet (86% versus 54%), an elongated posterior mitral leaflet (79% versus 77%) and fibrous endocardial plaque under the posterior mitral leaflet (73% versus 63%) was similar between the two groups. The severity of the prolapse (mild 20% versus 11%; moderate 27% versus 58%; severe 53% versus 32%) also was similar between the two groups. Thus, persons with mitral valve prolapse dying suddenly without another recognized condition tend to be relatively young women without mitral regurgitation. C1 NHLBI,PATHOL BRANCH,BLDG 10,ROOM 2N258,BETHESDA,MD 20892. NR 35 TC 46 Z9 48 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD MAR 15 PY 1991 VL 17 IS 4 BP 921 EP 931 PG 11 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA FB474 UT WOS:A1991FB47400014 PM 1999630 ER PT J AU HALLUM, JV HADLEY, SW AF HALLUM, JV HADLEY, SW TI NIH MISCONDUCT PROCEDURES - EFFECT OF NEW RULING SO SCIENCE LA English DT Letter RP HALLUM, JV (reprint author), NIH,OFF SCI INTEGR,BETHESDA,MD 20892, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 SN 0036-8075 J9 SCIENCE JI Science PD MAR 15 PY 1991 VL 251 IS 4999 BP 1296 EP 1296 DI 10.1126/science.2003214 PG 1 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FB733 UT WOS:A1991FB73300002 PM 2003214 ER PT J AU LIN, FH STOHS, SJ BIRNBAUM, LS CLARK, G LUCIER, GW GOLDSTEIN, JA AF LIN, FH STOHS, SJ BIRNBAUM, LS CLARK, G LUCIER, GW GOLDSTEIN, JA TI THE EFFECTS OF 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN (TCDD) ON THE HEPATIC ESTROGEN AND GLUCOCORTICOID RECEPTORS IN CONGENIC STRAINS OF AH RESPONSIVE AND AH NONRESPONSIVE C57BL/6J MICE SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article ID ARYL-HYDROCARBON HYDROXYLASE; RAT-LIVER; BINDING; INDUCTION; TOXICITY; MOUSE; CYTOCHROME-P1-450; PLASMA; LOCUS C1 NIEHS,BIOCHEM RISK ANAL LAB,POB 12233,RES TRIANGLE PK,NC 27709. NIEHS,SYST TOXICOL BRANCH,RES TRIANGLE PK,NC 27709. RI Goldstein, Joyce/A-6681-2012 NR 37 TC 72 Z9 72 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0041-008X J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD MAR 15 PY 1991 VL 108 IS 1 BP 129 EP 139 DI 10.1016/0041-008X(91)90276-K PG 11 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA FD607 UT WOS:A1991FD60700014 PM 1672475 ER PT J AU SANTOSTASI, G KUTTY, RK KRISHNA, G AF SANTOSTASI, G KUTTY, RK KRISHNA, G TI INCREASED TOXICITY OF ANTHRACYCLINE ANTIBIOTICS INDUCED BY CALCIUM ENTRY BLOCKERS IN CULTURED CARDIOMYOCYTES SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article ID MULTIDRUG-RESISTANCE; STRUCTURAL REQUIREMENTS; ADRIAMYCIN; VERAPAMIL; CELLS; ANTAGONISTS; CARDIOTOXICITY; ACCUMULATION; NIFEDIPINE; DILTIAZEM C1 NHLBI,CHEM PHARMACOL LAB,DRUG TISSUE INTERACT SECT,BETHESDA,MD 20892. NR 30 TC 13 Z9 14 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0041-008X J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD MAR 15 PY 1991 VL 108 IS 1 BP 140 EP 149 DI 10.1016/0041-008X(91)90277-L PG 10 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA FD607 UT WOS:A1991FD60700015 PM 2006501 ER PT J AU WATSON, JD AF WATSON, JD TI LURIA,SALVADOR,E. - (1912-1991) SO NATURE LA English DT Item About an Individual C1 NIH,BIOMED ENGN & INSTRUMENTAT BRANCH,NATL CTR HUMAN GENOME RES,BETHESDA,MD 20892. RP WATSON, JD (reprint author), COLD SPRING HARBOR LAB,COLD SPRING HARBOR,NY 11724, USA. NR 1 TC 3 Z9 3 U1 0 U2 0 PU MACMILLAN MAGAZINES LTD PI LONDON PA 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF SN 0028-0836 J9 NATURE JI Nature PD MAR 14 PY 1991 VL 350 IS 6314 BP 113 EP 113 DI 10.1038/350113a0 PG 1 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FB645 UT WOS:A1991FB64500035 PM 2005959 ER PT J AU KAPLAN, DR MARTINZANCA, D PARADA, LF AF KAPLAN, DR MARTINZANCA, D PARADA, LF TI TYROSINE PHOSPHORYLATION AND TYROSINE KINASE-ACTIVITY OF THE TRK PROTOONCOGENE PRODUCT INDUCED BY NGF SO NATURE LA English DT Article ID NERVE GROWTH-FACTOR; PHEOCHROMOCYTOMA CELL LINE; ACETYLCHOLINE; ACTIVATION; INCREASE; RECEPTOR AB NERVE growth factor (NGF) is a neurotrophic factor responsible for the differentiation and survival of sympathetic and sensory neurons as well as selective populations of cholinergic neurons 1,2. NGF binds to specific cell-surface receptors but the mechanism for transduction of the neurotrophic signal is unknown. Several experiments using the NGF-responsive pheochromocytoma cell line, PC12, have implicated tyrosine phosphorylation in NGF-mediated responses, although no NGF-specific tyrosine kinases have been identified 3. Here we show that NGF induces tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product, a tyrosine kinase receptor whose expression is restricted in vivo to neurons of the sensory spinal and cranial ganglia of neural crest origin 4. Tyrosine phosphorylation of trk by NGF is rapid, specific and occurs with picomolar quantities of factor, indicating that the response is mediated by physiological amounts of NGF. Activation of the trk tyrosine kinase receptor provides a possible mechanism for signal transduction by NGF. C1 NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,BETHESDA,MD 20892. RP KAPLAN, DR (reprint author), NCI,FREDERICK CANC RES & DEV CTR,EUKARYOT SIGNAL TRANSDUCT GRP,POB B,BETHESDA,MD 20892, USA. RI Parada, luis/B-9400-2014 NR 21 TC 871 Z9 873 U1 2 U2 9 PU MACMILLAN MAGAZINES LTD PI LONDON PA 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF SN 0028-0836 J9 NATURE JI Nature PD MAR 14 PY 1991 VL 350 IS 6314 BP 158 EP 160 DI 10.1038/350158a0 PG 3 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FB645 UT WOS:A1991FB64500060 PM 1706478 ER PT J AU WICKNER, S HOSKINS, J MCKENNEY, K AF WICKNER, S HOSKINS, J MCKENNEY, K TI FUNCTION OF DNAJ AND DNAK AS CHAPERONES IN ORIGIN-SPECIFIC DNA-BINDING BY REPA SO NATURE LA English DT Article ID P1 PLASMID REPLICATION; HEAT-SHOCK PROTEINS; ESCHERICHIA-COLI; GENE AB HEAT-shock proteins are normal constituents of cells whose synthesis is increased on exposure to various forms of stress. They are interesting because of their ubiquity and high conservation during evolution. Two families of heat-shock proteins, hsp60s and hsp70s, have been implicated in accelerating protein folding and oligomerization and also in maintaining proteins in an unfolded state, thus facilitating membrane transport 1-5. The Escherichia coli hsp70 analogue, DnaK, and two other heat-shock proteins, DnaJ and GrpE, are required for cell viability at high temperatures and are involved in DNA replication of phage-lambda and plasmids P1 and F 6-10. These three proteins are involved in replication in vitro of P1 DNA along with many host replication proteins and the P1 RepA initiator protein 11,12. RepA exists in a stable protein complex with DnaJ containing a dimer each of RepA and DnaJ 11. We report here that DnaK and DnaJ mediate an alteration in the P1 initiator protein, rendering it much more active for oriP1 DNA binding. C1 NATL INST STAND & TECHNOL,CTR ADV RES BIOTECHNOL,ROCKVILLE,MD 20850. RP WICKNER, S (reprint author), NCI,MOLEC BIOL LAB,BETHESDA,MD 20892, USA. NR 16 TC 190 Z9 191 U1 0 U2 3 PU MACMILLAN MAGAZINES LTD PI LONDON PA 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF SN 0028-0836 J9 NATURE JI Nature PD MAR 14 PY 1991 VL 350 IS 6314 BP 165 EP 167 DI 10.1038/350165a0 PG 3 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FB645 UT WOS:A1991FB64500063 PM 2005967 ER PT J AU SAAD, MF LILLIOJA, S NYOMBA, BL CASTILLO, C FERRARO, R DEGREGORIO, M RAVUSSIN, E KNOWLER, WC BENNETT, PH HOWARD, BV BOGARDUS, C AF SAAD, MF LILLIOJA, S NYOMBA, BL CASTILLO, C FERRARO, R DEGREGORIO, M RAVUSSIN, E KNOWLER, WC BENNETT, PH HOWARD, BV BOGARDUS, C TI RACIAL-DIFFERENCES IN THE RELATION BETWEEN BLOOD-PRESSURE AND INSULIN RESISTANCE SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID ESSENTIAL-HYPERTENSION; LIPID-METABOLISM; PIMA-INDIANS; GLUCOSE; HYPERINSULINEMIA; CHILDREN; SODIUM; MASS AB Background. Insulin resistance and the concomitant compensatory hyperinsulinemia have been implicated in the pathogenesis of hypertension. However, reports on the relation between insulin and blood pressure are inconsistent. This study was designed to investigate the possibility of racial differences in this relation. Methods. We studied 116 Pima Indians, 53 whites, and 42 blacks who were normotensive and did not have diabetes; the groups were comparable with respect to mean age (29, 30, and 31 years, respectively) and blood pressure (113/70, 111/68, and 113/68 mm Hg, respectively). Insulin resistance was determined by the euglycemic-hyperinsulinemic clamp technique during low-dose (40 mU per square meter of body-surface area per minute) and high-dose (400 mU per square meter per minute) insulin infusions. Results. The Pima Indians had higher fasting plasma insulin concentrations than the whites or blacks (176, 138, and 122 pmol per liter, respectively; P = 0.002) and lower rates of whole-body glucose disposal during both the low-dose (12.7, 17.1, and 19.5 mmol per minute; P < 0.001) and the high-dose (38.0, 43.1, and 45.7 mmol per minute; P < 0.001) insulin infusions. After adjustment for age, sex, body weight, and percentage of body fat, mean blood pressure (calculated as 1/3 systolic pressure + 2/3 diastolic pressure) was significantly correlated with the fasting plasma insulin concentration (r = 0.42) and the rate of glucose disposal during the low-dose (r = -0.41) and high-dose (r = -0.49) insulin infusions (P < 0.01 for each) in whites, but not in Pima Indians (r = -0.06, -0.02, and -0.04, respectively) or blacks (r = -0.10, -0.04, and 0.02, respectively. Conclusions. The relations between insulinemia, insulin resistance, and blood pressure differ among racial groups and may be mediated by mechanisms active in whites, but not in Pima Indians or blacks. C1 NIDDKD,PHOENIX EPIDEMIOL & CLIN RES BRANCH,PHOENIX,AZ. MEDLANTIC RES FDN,WASHINGTON,DC. RI Lillioja, Stephen/A-8185-2012; OI Lillioja, Stephen/0000-0001-5333-5240 NR 43 TC 387 Z9 399 U1 0 U2 1 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD MAR 14 PY 1991 VL 324 IS 11 BP 733 EP 739 DI 10.1056/NEJM199103143241105 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA FB556 UT WOS:A1991FB55600005 PM 1997839 ER PT J AU DOHERTY, GM AF DOHERTY, GM TI ADJUVANT THERAPY IN EPITHELIAL OVARIAN-CANCER SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter RP DOHERTY, GM (reprint author), NCI,BETHESDA,MD 20892, USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD MAR 14 PY 1991 VL 324 IS 11 BP 775 EP 775 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA FB556 UT WOS:A1991FB55600020 ER PT J AU REGIER, DA FARMER, ME RAE, DS LOCKE, BZ KEITH, SJ GOODWIN, FK JUDD, LL AF REGIER, DA FARMER, ME RAE, DS LOCKE, BZ KEITH, SJ GOODWIN, FK JUDD, LL TI COMORBIDITY OF MENTAL-DISORDERS AND NICOTINE DEPENDENCE - REPLY SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Letter C1 UNIV CALIF SAN DIEGO,LA JOLLA,CA 92093. RP REGIER, DA (reprint author), NIMH,ROCKVILLE,MD 20857, USA. NR 4 TC 0 Z9 0 U1 3 U2 3 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD MAR 13 PY 1991 VL 265 IS 10 BP 1257 EP 1257 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA FA511 UT WOS:A1991FA51100011 ER PT J AU BLOT, WJ DEVESA, SS KNELLER, RW FRAUMENI, JF AF BLOT, WJ DEVESA, SS KNELLER, RW FRAUMENI, JF TI RISING INCIDENCE OF ADENOCARCINOMA OF THE ESOPHAGUS AND GASTRIC CARDIA SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Note ID UNITED-STATES; BARRETTS ESOPHAGUS; CANCER AB Analyses of cancer incidence data from nine areas of the United States revealed steadily rising rates from 1976 to 1987 of adenocarcinomas of the esophagus and gastric cardia. The increases among men in this period ranged from 4% to 10% per year, and thus exceeded those of any other type of cancer. In contrast, there were relatively stable trends for squamous cell carcinoma of the esophagus and slight declines for adenocarcinoma of more distal portions of the stomach. Adenocarcinomas of the esophagus and gastric cardia disproportionately affected white men and rarely occurred among women. By the mid-1980s, among white men, adenocarcinomas accounted for about one third of all esophageal cancers, while cardia cancers accounted for about one half of all stomach cancers with specified subsites. The rising incidence rates and similar demographic patterns point to the need for investigation into the causes of these poorly understood cancers. RP BLOT, WJ (reprint author), NCI,BIOSTAT BRANCH,EPIDEMIOL & BIOSTAT PROGRAM,EPN,SUITE 431,BETHESDA,MD 20892, USA. NR 16 TC 1834 Z9 1875 U1 3 U2 18 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD MAR 13 PY 1991 VL 265 IS 10 BP 1287 EP 1289 DI 10.1001/jama.265.10.1287 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA FA511 UT WOS:A1991FA51100024 PM 1995976 ER PT J AU BOICE, JD MORIN, MM GLASS, AG FRIEDMAN, GD STOVALL, M HOOVER, RN FRAUMENI, JF AF BOICE, JD MORIN, MM GLASS, AG FRIEDMAN, GD STOVALL, M HOOVER, RN FRAUMENI, JF TI DIAGNOSTIC-X-RAY PROCEDURES AND RISK OF LEUKEMIA, LYMPHOMA, AND MULTIPLE-MYELOMA SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Note ID ACTIVE BONE-MARROW; CANCER MORTALITY; IONIZING-RADIATION; BREAST-CANCER; UNITED-STATES; RADIOGRAPHY; WORKERS; RADIOLOGISTS; CERVIX AB Exposure to diagnostic x-rays and the risk of leukemia, non-Hodgkin's lymphoma (NHL), and multiple myeloma were studied within two prepaid health plans. Adult patients with leukemia (n = 565), NHL (n = 318), and multiple myeloma (n = 208) were matched to controls (n = 1390), and over 25 000 x-ray procedures were abstracted from medical records. Dose response was evaluated by assigning each x-ray procedure a score based on estimated bone marrow dose. X-ray exposure was not associated with chronic lymphocytic leukemia, one of the few malignant conditions never linked to radiation (relative risk [RR], 0.66). For all other forms of leukemia combined (n = 358), there was a slight elevation in risk (RR, 1.17) but no evidence of a dose-response relationship when x-ray procedures near the time of diagnosis were excluded. Similarly, patients with NHL were exposed to diagnostic x-ray procedures more often than controls (RR, 1.32), but the RR fell to 0.99 when the exposure to diagnostic x-ray procedures within 2 years of diagnosis was ignored. For multiple myeloma, overall risk was not significantly high (RR, 1.14), but there was consistent evidence of increasing risk with increasing numbers of diagnostic x-ray procedures. These data suggest that persons with leukemia and NHL undergo x-ray procedures frequently just prior to diagnosis for conditions related to the development or natural history of their disease. There was little evidence that diagnostic x-ray procedures were causally associated with leukemia or NHL. The risk for multiple myeloma, however, was increased among those patients who were frequently exposed to x-rays. C1 KAISER PERMANENTE MED CARE PROGRAM,PORTLAND,OR. KAISER PERMANENTE MED CARE PROGRAM,OAKLAND,CA. MD ANDERSON CANC CTR,HOUSTON,TX. RP BOICE, JD (reprint author), NCI,DIV CANC ETIOL,RADIAT EPIDEMIOL BRANCH,EPIDEMIOL & BIOSTAT PROGRAM,6130 EXECUT BLVD,BETHESDA,MD 20852, USA. FU NCI NIH HHS [N01-CP0-1047, N01-CP1-1009, N01-CP0-1054] NR 55 TC 84 Z9 85 U1 0 U2 3 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD MAR 13 PY 1991 VL 265 IS 10 BP 1290 EP 1294 DI 10.1001/jama.265.10.1290 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA FA511 UT WOS:A1991FA51100025 PM 2053936 ER PT J AU DEERFIELD, DW FOX, DJ HEADGORDON, M HISKEY, RG PEDERSEN, LG AF DEERFIELD, DW FOX, DJ HEADGORDON, M HISKEY, RG PEDERSEN, LG TI INTERACTION OF CALCIUM AND MAGNESIUM-IONS WITH MALONATE AND THE ROLE OF THE WATERS OF HYDRATION - A QUANTUM-MECHANICAL STUDY SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Article ID BOVINE PROTHROMBIN FRAGMENT-1; GAMMA-CARBOXYGLUTAMIC ACID; RARE-EARTH CARBOXYLATES; CHEMICAL MODIFICATION; MOLECULAR-STRUCTURE; CRYSTAL-STRUCTURE; MELDRUMS ACID; TB-3+ IONS; BINDING; TRIHYDRATE AB The structure of malonate interacting with either a Ca(II) or a Mg(II) ion in a chelation bidentate orientation has been studied with ab initio molecular orbital theory. In addition, the optimized chelation bidentate structures have also been determined for the enol tautomer of malonate ion and two different deprotonated forms of the malonate-metal ion complex. All malonate-derived structures were optimized with and without four waters of hydration about the divalent metal ion. The enol tautomer of malonate was found to be less stable than the keto form complexed with either Ca(II) or Mg(II) ions. Computations have demonstrated that removal of a proton from one of the waters of hydration about the divalent metal ion leads to a structure that is calculated to be more stable than the structure resulting from the deprotonation on carbon of the malonate complex. A mechanism for the chemical modification and proton exchange of proteins containing gamma-carboxyglutamic acid (e.g., prothrombin), for which malonic acid serves as a model, is proposed. C1 UNIV N CAROLINA,DEPT CHEM,CHAPEL HILL,NC 27599. AT&T BELL LABS,MURRAY HILL,NJ 07974. NIEHS,RES TRIANGLE PK,NC 27709. RP DEERFIELD, DW (reprint author), PITTSBURGH SUPERCOMP CTR,4400 5TH AVE,PITTSBURGH,PA 15213, USA. RI Pedersen, Lee/E-3405-2013 OI Pedersen, Lee/0000-0003-1262-9861 NR 44 TC 13 Z9 13 U1 1 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD MAR 13 PY 1991 VL 113 IS 6 BP 1892 EP 1899 DI 10.1021/ja00006a004 PG 8 WC Chemistry, Multidisciplinary SC Chemistry GA FB940 UT WOS:A1991FB94000004 ER PT J AU FORMANKAY, JD CLORE, GM WINGFIELD, PT GRONENBORN, AM AF FORMANKAY, JD CLORE, GM WINGFIELD, PT GRONENBORN, AM TI HIGH-RESOLUTION 3-DIMENSIONAL STRUCTURE OF REDUCED RECOMBINANT HUMAN THIOREDOXIN IN SOLUTION SO BIOCHEMISTRY LA English DT Article ID NUCLEAR MAGNETIC-RESONANCE; RESTRAINED MOLECULAR-DYNAMICS; ESCHERICHIA-COLI THIOREDOXIN; POTATO CARBOXYPEPTIDASE INHIBITOR; INTERPROTON DISTANCE RESTRAINTS; B-CELL LINE; SECONDARY STRUCTURE; PROTON NMR; PROTEIN-STRUCTURE; GEOMETRY AB The solution structure of recombinant human thioredoxin (105 residues) has been determined by nuclear magnetic resonance (NMR) spectroscopy combined with hybrid distance geometry-dynamical simulated annealing calculations. Approximate interproton distance restraints were derived from nuclear Overhauser effect (NOE) measurements. In addition, a large number of stereospecific assignments for beta-methylene protons and torsion angle restraints for phi, psi, and chi-1 were obtained by using a conformational grid search on the basis of the intraresidue and sequential NOE data in conjunction with 3J(HN-alpha) and 3J(alpha-beta) coupling constants. The structure calculations were based on 1983 approximate interproton distance restraints, 52 hydrogen-bonding restraints for 26 hydrogen bonds, and 98 phi, 71 psi, and 72 chi-1 torsion angle restraints. The 33 final simulated annealing structures obtained had an average atomic rms distribution of the individual structures about the mean coordinate positions of 0.40 +/- 0.06 angstrom for the backbone atoms and 0.78 +/- 0.05 angstrom for all atoms. The solution structure of human thioredoxin consists of a five-stranded beta-sheet surrounded by four alpha-helices, with an active site protrusion containing the two redox-active cysteines. The overall structure is similar to the crystal and NMR structures of oxidized [Katti, S. K., LeMaster, D. M., & Eklund, H. (1990) J. Mol. Biol. 212, 167-184] and reduced [Dyson, J. H., Gippert, G. P., Case, D. A., Holmgren, A., & Wright, P. (1990) Biochemistry 29, 4129-4136] Escherichia coli thioredoxin, respectively, despite the moderate 25% amino acid sequence homology. Several differences, however, can be noted. The human alpha-1 helix is a full turn longer than the corresponding helix in E. coli thioredoxin and is characterized by a more regular helical geometry. The helix labeled alpha-3 in human thioredoxin has its counterpart in the 3(10) helix of the E. coli protein and is also longer in the human protein. In contrast to these structural differences, the conformation of the active site loop in both proteins is very similar, reflecting the perfect sequence identity for a stretch of eight amino acid residues around the redox-active cysteines. C1 NIDDKD,CHEM PHYS LAB,BLDG 2,BETHESDA,MD 20892. NIH,PROT EXPRESS LAB,BETHESDA,MD 20892. YALE UNIV,DEPT MOLEC BIOPHYS & BIOCHEM,NEW HAVEN,CT 06511. RI Clore, G. Marius/A-3511-2008 OI Clore, G. Marius/0000-0003-3809-1027 FU NIGMS NIH HHS [GM-22778] NR 73 TC 134 Z9 137 U1 0 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0006-2960 J9 BIOCHEMISTRY-US JI Biochemistry PD MAR 12 PY 1991 VL 30 IS 10 BP 2685 EP 2698 DI 10.1021/bi00224a017 PG 14 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA FB414 UT WOS:A1991FB41400017 PM 2001356 ER PT J AU ANTTILA, S HIETANEN, E VAINIO, H CAMUS, AM GELBOIN, HV PARK, SS HEIKKILA, L KARJALAINEN, A BARTSCH, H AF ANTTILA, S HIETANEN, E VAINIO, H CAMUS, AM GELBOIN, HV PARK, SS HEIKKILA, L KARJALAINEN, A BARTSCH, H TI SMOKING AND PERIPHERAL TYPE OF CANCER ARE RELATED TO HIGH-LEVELS OF PULMONARY CYTOCHROME-P450IA IN LUNG-CANCER PATIENTS SO INTERNATIONAL JOURNAL OF CANCER LA English DT Article ID MONOCLONAL-ANTIBODIES; BENZOPYRENE METABOLISM; RISK; CYTOCHROMES-P-450; CARCINOGENESIS; ENZYMES AB A specific member of the cytochrome P450 superfamily of enzymes, designated P4501A (including 2 isozymes, P4501A1 and P4501A2), which is involved in the metabolic activation of polycyclic aromatic hydrocarbons and aromatic amines, was studied in lung tissue from 25 lung cancer patients by immunohistochemistry. The pulmonary activity of a P4501A1-dependent enzyme, aryl hydrocarbon hydroxylase (AHH), from the same patients was also measured. Cytochrome P4501A was localized principally in the peripheral airways in alveolar epithelium of types I and II and in ciliated columnar and cuboidal bronchiolar epithelium. The amount of P4501A in the bronchial wall was minimal and was localized mainly in the capillary endothelium and the epithelium of the bronchial glands. Smoking was the most important factor related to the presence of P4501A and the AHH activity in lung tissue. None of the 10 ex-smokers, but all except 1 of the current smokers had detectable levels of P4501A. The localization of the cancer was also correlated with the presence of cytochrome P4501A. Peripheral lung tissue stained positively in all patients with a peripheral adenocarcinoma who currently smoked (8/8) but in less than half of those with a bronchial cancer who were smokers (3/7). Our data suggest that the smokers who have an inducible cytochrome P4501A are especially at increased risk of developing lung cancer of the peripheral adenocarcinomatous type. C1 UNIV TURKU,CENT HOSP,DEPT CLIN PHYSIOL,SF-20520 TURKU 52,FINLAND. INT AGCY RES CANC,F-69372 LYONS,FRANCE. UNIV HELSINKI,CENT HOSP,DEPT THORAC & CARDIOVASC SURG,SF-00100 HELSINKI 10,FINLAND. NCI,BETHESDA,MD 20892. RP ANTTILA, S (reprint author), INST OCCUPAT HLTH,TOPELIUKSENKATU 41 AA,SF-00250 HELSINKI,FINLAND. NR 27 TC 114 Z9 114 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0020-7136 J9 INT J CANCER JI Int. J. Cancer PD MAR 12 PY 1991 VL 47 IS 5 BP 681 EP 685 DI 10.1002/ijc.2910470509 PG 5 WC Oncology SC Oncology GA FC757 UT WOS:A1991FC75700008 PM 1848536 ER PT J AU RABKIN, CS BIGGAR, RJ HORM, JW AF RABKIN, CS BIGGAR, RJ HORM, JW TI INCREASING INCIDENCE OF CANCERS ASSOCIATED WITH THE HUMAN-IMMUNODEFICIENCY-VIRUS EPIDEMIC SO INTERNATIONAL JOURNAL OF CANCER LA English DT Article ID NON-HODGKINS LYMPHOMA; SAN-FRANCISCO; SYNDROME AIDS; HOMOSEXUAL MEN; LOS-ANGELES; RISK; TRENDS; INFECTION; POPULATION; DISEASE AB We examined data from San Francisco and other areas participating in the Surveillance, Epidemiology, and End Results (SEER) Program to determine the effect of the human immunodeficiency virus (HIV) epidemic on cancer incidence between 1973 and 1987. In this period, non-Hodgkin's lymphoma incidence has increased over 10-fold and Kaposi's sarcoma incidence has increased over 5000-fold in single San Francisco men 20 to 49 years of age. Increases in non-Hodgkin's lymphoma have been restricted to high-grade and diffuse large-cell (intermediate-grade) histological types. With the exceptions of non-Hodgkin's lymphoma and Kaposi's sarcoma, no other tumor has significantly increased in incidence. During 1987, we estimate that HIV-seropositive men in San Francisco had a 0.47% risk of developing non-Hodgkin's lymphoma and a 1.6% risk of developing Kaposi's sarcoma. The relative risks for non-Hodgkin's lymphoma and Kaposi's sarcoma associated with HIV infection were 104 and 40,000, respectively. For 1987, HIV was associated with 14% of all reported cancers (except non-melanoma skin cancer) in men aged 20 to 49. We expect that 1,890 to 2,730 excess cases of non-Hodgkin's lymphoma and 6,490 to 8,320 excess cases of Kaposi's sarcoma will occur in the United States in 1990. C1 NCI, SPECIAL POPULAT STUDIES BRANCH, BETHESDA, MD 20892 USA. RP RABKIN, CS (reprint author), NCI, ENVIRONM EPIDEMIOL BRANCH, BETHESDA, MD 20892 USA. NR 46 TC 123 Z9 124 U1 2 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0020-7136 EI 1097-0215 J9 INT J CANCER JI Int. J. Cancer PD MAR 12 PY 1991 VL 47 IS 5 BP 692 EP 696 DI 10.1002/ijc.2910470511 PG 5 WC Oncology SC Oncology GA FC757 UT WOS:A1991FC75700010 PM 2004849 ER PT J AU TOBIAS, BI AF TOBIAS, BI TI EXPLOSIONS FROM ORGANIC AZIDES, PEROXIDES SO CHEMICAL & ENGINEERING NEWS LA English DT Letter C1 FREDERICK CANC RES & DEV CTR,ENVIRONM CONTROL & RES PROGRAM,FREDERICK,MD 21701. NR 0 TC 2 Z9 2 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0009-2347 J9 CHEM ENG NEWS JI Chem. Eng. News PD MAR 11 PY 1991 VL 69 IS 10 BP 2 EP 2 PG 1 WC Chemistry, Multidisciplinary; Engineering, Chemical SC Chemistry; Engineering GA FA985 UT WOS:A1991FA98500001 ER PT J AU ABRAMS, SA ESTEBAN, NV VIEIRA, NE GOANS, RE COVELL, DG MARINI, JC SIDBURY, JB SPECKER, BL YERGEY, AL AF ABRAMS, SA ESTEBAN, NV VIEIRA, NE GOANS, RE COVELL, DG MARINI, JC SIDBURY, JB SPECKER, BL YERGEY, AL TI NON-COMPARTMENTAL ANALYSIS OF CALCIUM KINETICS DEMONSTRATE DEVELOPMENTAL-CHANGES IN MEAN RESIDENCE TIME AND ABNORMALITIES IN BODY POOLS IN OSTEOGENESIS IMPERFECTA SO FASEB JOURNAL LA English DT Meeting Abstract C1 NICHHD,BETHESDA,MD 20892. NR 0 TC 1 Z9 1 U1 2 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A560 EP A560 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20701098 ER PT J AU AKSENTIJEVICH, I SACHS, DH SYKES, M AF AKSENTIJEVICH, I SACHS, DH SYKES, M TI EFFECT OF NATURAL ANTIBODY ON CROSS-SPECIES BONE-MARROW ENGRAFTMENT SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,IMMUNOL BRANCH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A731 EP A731 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20702093 ER PT J AU ALBORNOZ, L JONES, JM CRUTCHFIELD, C VEECH, RL AF ALBORNOZ, L JONES, JM CRUTCHFIELD, C VEECH, RL TI NATURAL-KILLER (NK) ACTIVITY OF PIT CELLS PERFUSED FROM LIVERS OF RATS TREATED WITH ETHANOL SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIAAA,ROCKVILLE,MD 20852. UNIV ARKANSAS MED SCI HOSP,LITTLE ROCK,AR 72205. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A844 EP A844 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20702750 ER PT J AU ANASTASSIOU, ED YAMADA, H BOUMPAS, DT TSOKOS, GC THYPHRONITIS, G BALOW, J MOND, JJ AF ANASTASSIOU, ED YAMADA, H BOUMPAS, DT TSOKOS, GC THYPHRONITIS, G BALOW, J MOND, JJ TI CHOLERA-TOXIN PROMOTES THE PROLIFERATION OF ANTI-MU ANTIBODY PRESTIMULATED HUMAN B-CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIH,BETHESDA,MD 20892. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A610 EP A610 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20701387 ER PT J AU ATTAASAFOADJEI, E LAWTON, MP PHILPOT, RM AF ATTAASAFOADJEI, E LAWTON, MP PHILPOT, RM TI CLONING AND SEQUENCING OF A CDNA-ENCODING A 3RD FLAVIN-CONTAINING MONOOXYGENASE IN RABBITS SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIEHS,RES TRIANGLE PK,NC 27709. NR 1 TC 2 Z9 2 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A843 EP A843 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20702745 ER PT J AU BABILA, T SCHAAD, NC SPIEGEL, AM SHINOHARA, T KLEIN, DC AF BABILA, T SCHAAD, NC SPIEGEL, AM SHINOHARA, T KLEIN, DC TI DEVELOPMENTAL APPEARANCE OF CYTOSOLIC G-BETA, CYTOSOLIC MEKA, AND MEMBRANE-ASSOCIATED G-PROTEINS IN THE RAT PINEAL-GLAND SO FASEB JOURNAL LA English DT Meeting Abstract C1 NICHHD,NEUROENDOCRINOL SECT,DEV NEUROBIOL LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A408 EP A408 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20700220 ER PT J AU BACKLUND, PS AF BACKLUND, PS TI SEPARATION OF GUANINE-NUCLEOTIDE STIMULATED METHYL-TRANSFERASE ACTIVITIES SPECIFIC FOR DISTINCT-23 KDA MEMBRANE-PROTEINS IN BRAIN SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIMH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A455 EP A455 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20700490 ER PT J AU BALASUNDARAM, D TABOR, CW TABOR, H AF BALASUNDARAM, D TABOR, CW TABOR, H TI SPERMIDINE IS ESSENTIAL FOR THE GROWTH OF SACCHAROMYCES-CEREVISIAE - CONSTRUCTION OF AN INSERTION-DELETION MUTATION IN THE GENE (SPE2) FOR S-ADENOSYLMETHIONINE DECARBOXYLASE SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A504 EP A504 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20700769 ER PT J AU BLAYLOCK, BL KOUCHI, Y COMMENT, CE CORSINI, E ROSENTHAL, GJ LUSTER, MI AF BLAYLOCK, BL KOUCHI, Y COMMENT, CE CORSINI, E ROSENTHAL, GJ LUSTER, MI TI PENTAMIDINE ISETHIONATE MODULATES THE CONTACT HYPERSENSITIVITY RESPONSE IN MICE SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIEHS,IMMUNOTOXICOL GRP,RES TRIANGLE PK,NC 27709. RI Corsini, Emanuela/B-5602-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A508 EP A508 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20700793 ER PT J AU BOGARDUS, C RISING, R FONTVIEILLE, AM FERRARO, R RAVUSSIN, E AF BOGARDUS, C RISING, R FONTVIEILLE, AM FERRARO, R RAVUSSIN, E TI RELATIONSHIP BETWEEN BODY-TEMPERATURE AND METABOLIC-RATE IN PIMA INDIAN MEN SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIDDK,CDNS,PHOENIX,AZ 85016. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A554 EP A554 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20701064 ER PT J AU BOUMPAS, DT ANASTASSIOU, ED THYPHRONITIS, G PALIOGIANI, F BALOW, JE AF BOUMPAS, DT ANASTASSIOU, ED THYPHRONITIS, G PALIOGIANI, F BALOW, JE TI GENE-TRANSCRIPTION IN HUMAN B-CELLS ACTIVATED BY IL-4 SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A609 EP A609 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20701386 ER PT J AU BOYER, TD KEMPNER, E AF BOYER, TD KEMPNER, E TI EFFECT OF SUBUNIT INTERACTIONS ON ENZYMATIC-ACTIVITY OF RAT GLUTATHIONE S-TRANSFERASES (GST) SO FASEB JOURNAL LA English DT Meeting Abstract C1 EMORY UNIV,SCH MED,ATLANTA,GA 30322. NIH,PHYS BIOL LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A431 EP A431 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20700348 ER PT J AU BRADY, RO FURBISH, FS BARTON, NW AF BRADY, RO FURBISH, FS BARTON, NW TI ENZYME REPLACEMENT IN GAUCHER DISEASE WITH MACROPHAGE-TARGETED HUMAN PLACENTAL GLUCOCEREBROSIDASE SO FASEB JOURNAL LA English DT Meeting Abstract C1 NIH,BETHESDA,MD 20892. GENZYME CORP,CAMBRIDGE,MA 01239. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A755 EP A755 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20702234 ER PT J AU BRAUNSTEIN, NS WEBER, DA LONG, EO KARP, DR AF BRAUNSTEIN, NS WEBER, DA LONG, EO KARP, DR TI MHC POLYMORPHISMS WHICH DIRECT THE BINDING OF TSST-1 SO FASEB JOURNAL LA English DT Meeting Abstract C1 COLUMBIA UNIV,DEPT MED,NEW YORK,NY 10032. NIAID,LIG,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A723 EP A723 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20702050 ER PT J AU BRYANT, DK FENSELAU, C BOWERS, MA HENDERSON, LE AF BRYANT, DK FENSELAU, C BOWERS, MA HENDERSON, LE TI AMINO-ACID SEQUENCING OF THE HIV-1/MN GAG P17 PROTEIN BY 4-SECTOR TANDEM MASS-SPECTROMETRY SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV MARYLAND,CATONSVILLE,MD 21228. PRI DYN CORP,FREDERICK CANC RES & DEV CTR,FREDERICK,MD 21702. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A443 EP A443 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20700420 ER EF