FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Gross, ML Hedman, TD Son, SF Jackson, TL Beckstead, MW AF Gross, Matthew L. Hedman, Trevor D. Son, Steven F. Jackson, Thomas L. Beckstead, Merrill W. TI Coupling micro and meso-scale combustion models of AP/HTPB propellants SO COMBUSTION AND FLAME LA English DT Article DE Ammonium perchlorate; Hydroxyl-terminated polybutadiene; Solid propellants; Combustion modeling; Multi-scale coupling ID COMPOSITE PROPELLANTS; AMMONIUM-PERCHLORATE AB Combustion simulations at the micro and meso-scales are coupled to give a more theoretically based and accurate description of AP (ammonium perchlorate)/HTPB (hydroxyl-terminated polybutadiene) composite propellant combustion. One and two-dimensional micro-scale combustion models of AP and AP/HTPB, which include detailed kinetics and species transport, are utilized to define semi-global kinetics for a meso-scale propellant combustion model capable of representing the complex morphology of an actual propellant. The AP/HTPB flame structure predicted with the micro-scale models is separated into four flames. Each flame is represented with a single reaction, thus a new four-step kinetic mechanism is implemented into the meso-scale model. Physical and kinetic parameters are determined with the micro-scale models. The meso-scale model is calibrated and validated with the micro-scale models to ensure the correct flame structure, as a function of pressure and AP particle sizes, is recreated with the four-step mechanism. The primary focus of this work is to outline the methodology used to couple the two numerical scales. Results of the meso-scale model are compared with the previous empirically-parameterized meso-scale model results and experimental data. Predictions are within 10% of experimental values for a range of AP/HTPB propellants. Published by Elsevier Inc. on behalf of The Combustion Institute. C1 [Gross, Matthew L.] USN, Air Warfare Ctr, Weap Div, China Lake, CA 93555 USA. [Hedman, Trevor D.; Son, Steven F.] Purdue Univ, Maurice J Zucrow Labs, W Lafayette, IN 47906 USA. [Jackson, Thomas L.] Univ Illinois, Urbana, IL 61801 USA. [Beckstead, Merrill W.] Brigham Young Univ, Provo, UT 84602 USA. RP Gross, ML (reprint author), USN, Adm Circle, Air Warfare Ctr, Weap Div, China Lake, CA 93555 USA. EM matthew.gross1@navy.mil FU NAVAIR ILIR program; N-STAR program FX This work was sponsored by the NAVAIR ILIR program, managed at ONR by the N-STAR program. Additionally, the authors wish to thank the SMART Scholarship. NR 23 TC 8 Z9 9 U1 0 U2 38 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0010-2180 J9 COMBUST FLAME JI Combust. Flame PD MAY PY 2013 VL 160 IS 5 BP 982 EP 992 DI 10.1016/j.combustflame.2013.01.016 PG 11 WC Thermodynamics; Energy & Fuels; Engineering, Multidisciplinary; Engineering, Chemical; Engineering, Mechanical SC Thermodynamics; Energy & Fuels; Engineering GA 109MM UT WOS:000316372700012 ER PT J AU Lin, RQ Smith, T AF Lin, Ray-Qing Smith, Tim TI Numerical Modeling of a Planing Hull Maneuvering in a Regular Wave, Part 1: Dynamic Instability SO JOURNAL OF SHIP PRODUCTION AND DESIGN LA English DT Article DE planing hull; maneuvering; incident waves; dynamic instability; numerical modeling ID SHIP MOTION; CONSISTENT; STABILITY; CRAFT AB The surf rescue boat (SRB) of the U.S. Coast Guard is a class of high-speed planing boats. This 9-meter craft is capable of operating at speeds up to Froude number 1.7. However, when it begins to maneuver in incident waves near its maximum speed, dynamic instability occurs immediately. In this instance, the craft trims and rolls to a large heel angle with "plow-In," even with small-amplitude incident waves and small course changes. In this study, a fully nonlinear ship motion model named the Digital Self-consistent Ship Experimental Laboratory (DiSSEL) is used as a numerical tool to understand the physics that cause the dynamic instabilities. DiSSEL showed that when SRB reached Froude number 1.698, acceleration resulting from heading change would cause a dynamic force and moment imbalance, resulting in heel and pitch motion instabilities. DiSSEL also showed that if the heading is fixed, and other conditions remain the same, the instability did not occur. Unfortunately, there is no detailed record of the data or numerical simulation of the ship motions in the stable and unstable regions, except for the description of the ship motions by Codega and Lewis (1987). The simulations by DiSSEL agree well with this description. C1 [Lin, Ray-Qing; Smith, Tim] Naval Surface Warfare Ctr, Carderock Div NSWCCD, Hydromech Dept, West Bethesda, MD 20817 USA. RP Lin, RQ (reprint author), Naval Surface Warfare Ctr, Carderock Div NSWCCD, Hydromech Dept, West Bethesda, MD 20817 USA. FU David Taylor Model Basin, Carderock Division, Naval Surface Warfare Center, Independent Laboratory In-House Research (ILIR) FX This work and the development of DiSSEL Ship Motion Model are supported by David Taylor Model Basin, Carderock Division, Naval Surface Warfare Center, Independent Laboratory In-House Research (ILIR) Program administered by Dr. Barkyoumb. NR 15 TC 0 Z9 0 U1 0 U2 1 PU SOC NAVAL ARCHITECTS MARINE ENGINEERS PI JERSEY CITY PA 601 PAVONIA AVENUE, JERSEY CITY, NJ 07306 USA SN 2158-2866 EI 2158-2874 J9 J SHIP PROD DES JI J. Ship Prod. Des. PD MAY PY 2013 VL 29 IS 2 BP 76 EP 83 DI 10.5957/JSPD.29.2.120036 PG 8 WC Engineering, Marine SC Engineering GA AW0CR UT WOS:000345958400004 ER PT J AU Freeman, W Karunasiri, G AF Freeman, Will Karunasiri, Gamani TI Nonresonant tunneling phonon depopulated GaN based terahertz quantum cascade structures SO APPLIED PHYSICS LETTERS LA English DT Article ID ELECTRON-ELECTRON SCATTERING; LASERS; WELLS; ROUGHNESS; INTERFACE; TRANSPORT; DESIGN AB GaN based terahertz quantum cascade structures are theoretically studied. Since the Frohlich interaction is similar to 15 times higher in GaN than in GaAs, level broadening makes obtaining appreciable optical gain difficult even with a large population inversion. A density matrix Monte Carlo method is used to calculate the broadening of the optical gain spectra as a function of lattice temperature. We find by using a proposed method of nonresonant tunneling and electron-longitudinal-optical phonon scattering for depopulation of the lower lasing state, that it is possible to sufficiently isolate the upper lasing state and control the lower lasing state lifetime to obtain high optical gain in GaN. The results predict lasing out to 300 K which is significantly higher than for GaAs based structures. [http://dx.doi.org/10.1063/1.4801947] C1 [Freeman, Will] USN, Air Warfare Ctr, Div Phys, China Lake, CA 93555 USA. [Karunasiri, Gamani] USN, Postgrad Sch, Dept Phys, Monterey, CA 93943 USA. RP Freeman, W (reprint author), USN, Air Warfare Ctr, Div Phys, China Lake, CA 93555 USA. EM will.freeman@navy.mil FU Section 219 FX This work is supported by Section 219. NR 30 TC 2 Z9 2 U1 3 U2 20 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD APR 15 PY 2013 VL 102 IS 15 AR 152111 DI 10.1063/1.4801947 PG 4 WC Physics, Applied SC Physics GA 135EC UT WOS:000318269200042 ER PT J AU Shu, IW Onton, JA Matthews, SC AF Shu, I-Wei Onton, Julie A. Matthews, Scott C. TI INCREASED MID-CINGULATE RESPONSES TO INHIBITORY STIMULI IN VETERANS WITH PTSD AFTER COMBAT-RELATED CONCUSSION SO PSYCHOSOMATIC MEDICINE LA English DT Meeting Abstract CT 71st Annual Scientific Meeting of the American-Psychosomatic-Society CY MAR 13-16, 2013 CL Miami, FL SP Amer Psychosomat Soc C1 [Shu, I-Wei; Matthews, Scott C.] Vet Affairs San Diego Healthcare Syst, Psychiat Serv, San Diego, CA USA. [Onton, Julie A.] Naval Hlth Res Ctr, San Diego, CA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0033-3174 EI 1534-7796 J9 PSYCHOSOM MED JI Psychosom. Med. PD APR PY 2013 VL 75 IS 3 BP A144 EP A144 PG 1 WC Psychiatry; Psychology; Psychology, Multidisciplinary SC Psychiatry; Psychology GA 300MG UT WOS:000330467400458 ER PT J AU Shu, IW Matthews, SC Onton, JA AF Shu, I-Wei Matthews, Scott C. Onton, Julie A. TI VETERANS WITH PTSD AFTER COMBAT-RELATED CONCUSSION EXHIBIT ALTERED POSTERIOR CINGULATE ACTIVITY WHILE APPRAISING FACIAL EMOTIONS SO PSYCHOSOMATIC MEDICINE LA English DT Meeting Abstract CT 71st Annual Scientific Meeting of the American-Psychosomatic-Society CY MAR 13-16, 2013 CL Miami, FL SP Amer Psychosomat Soc C1 [Shu, I-Wei; Matthews, Scott C.] Vet Affairs San Diego Healthcare Syst, Psychiat Serv, San Diego, CA USA. [Onton, Julie A.] Naval Hlth Res Ctr, San Diego, CA USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0033-3174 EI 1534-7796 J9 PSYCHOSOM MED JI Psychosom. Med. PD APR PY 2013 VL 75 IS 3 BP A44 EP A44 PG 1 WC Psychiatry; Psychology; Psychology, Multidisciplinary SC Psychiatry; Psychology GA 300MG UT WOS:000330467400143 ER PT J AU Bliss, T Iwasaki, T Bart-Smith, H AF Bliss, Thomas Iwasaki, Tetsuya Bart-Smith, Hilary TI Central Pattern Generator Control of a Tensegrity Swimmer SO IEEE-ASME TRANSACTIONS ON MECHATRONICS LA English DT Article DE Automatic control; nonlinear control systems; resonance ID NATURAL OSCILLATIONS; SENSORY FEEDBACK; ENTRAINMENT; ROBOT; LOCOMOTION; DYNAMICS; DEPLOYMENT; MECHANICS; RESONANCE; STIFFNESS AB Rhythmic motion employed in animal locomotion is ultimately controlled by neuronal circuits known as central pattern generators (CPGs). It appears that these controllers produce efficient, oscillatory command signals by entraining to an efficient or economic gait via sensory feedback. This property is of great interest in the control of autonomous vehicles. The objective of this study is to experimentally validate synthesized CPG control of a tensegrity swimmer. The prestressed cables in a tensegrity structure provide a method of simultaneous actuation and sensing, analogous to the biological motor control mechanism of regulating muscle stiffness through motoneuron activation and sensing the resulting motion by stretch receptors. A three cell, class 2 tensegrity swimmer is designed and built, and open-loop control tests characterize its swimming performance. We then determine gaits for desired entrainment, and use a graphical design method to construct and test the closed-loop system. Lastly, we perform perturbed tests of the swimmer to illustrate the robustness of CPG control. C1 [Bliss, Thomas] Naval Surface Warfare Ctr, Carderock Div, West Bethesda, MD 20817 USA. [Iwasaki, Tetsuya] Univ Calif Los Angeles, Los Angeles, CA 90095 USA. [Bart-Smith, Hilary] Univ Virginia, Charlottesville, VA 22904 USA. RP Bliss, T (reprint author), Naval Surface Warfare Ctr, Carderock Div, West Bethesda, MD 20817 USA. EM tkb2c@virginia.edu; tiwasaki@ucla.edu; hb8h@virginia.edu FU Office of Naval Research through the MURI [N00014-08-1-0642]; David and Lucille Packard Foundation [2003-25897]; National Science Foundation [NSF-0654070]; Achievement Rewards for College Scientists Metro Washington Chapter; Virginia Space Grant Consortium FX This work was supported in part by the Office of Naval Research through the MURI program on Biologically-Inspired Autonomous Sea Vehicles under Contract N00014-08-1-0642, in part by the David and Lucille Packard Foundation under Contract 2003-25897, and in part by the National Science Foundation under Contract NSF-0654070. The work of T. Bliss was also supported by the Achievement Rewards for College Scientists Metro Washington Chapter and the Virginia Space Grant Consortium. NR 48 TC 13 Z9 13 U1 0 U2 18 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1083-4435 J9 IEEE-ASME T MECH JI IEEE-ASME Trans. Mechatron. PD APR PY 2013 VL 18 IS 2 BP 586 EP 597 DI 10.1109/TMECH.2012.2210905 PG 12 WC Automation & Control Systems; Engineering, Manufacturing; Engineering, Electrical & Electronic; Engineering, Mechanical SC Automation & Control Systems; Engineering GA 172MN UT WOS:000321008100018 ER PT J AU Jensen, A Congalton, R Niederberger, B Jaworski, R Kelly, K AF Jensen, Andrew Congalton, Robert Niederberger, Brenda Jaworski, Rebecca Kelly, Karen TI Genetics of physical performance in US Marines SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Jensen, Andrew; Congalton, Robert; Niederberger, Brenda; Jaworski, Rebecca; Kelly, Karen] USN, Dept Warfighter Performance, Hlth Res Ctr, San Diego, CA 92152 USA. [Jaworski, Rebecca] Marine Corps Syst Command, Quantico, VA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 1212.3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860500480 ER PT J AU Kelly, K Jensen, A Niederberger, B Congalton, R Jaworski, R AF Kelly, Karen Jensen, Andrew Niederberger, Brenda Congalton, Robert Jaworski, Rebecca TI Overall stress response is reduced in US Marines following infantry training SO FASEB JOURNAL LA English DT Meeting Abstract CT Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB) CY APR 20-24, 2013 CL Boston, MA SP ASPET, British Pharmacol Soc (BPS) C1 [Kelly, Karen; Jensen, Andrew; Niederberger, Brenda; Congalton, Robert; Jaworski, Rebecca] USN, Dept Warfighter Performance, Hlth Res Ctr, San Diego, CA 92152 USA. [Jaworski, Rebecca] Marine Corps Syst Command, Quantico, VA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2013 VL 27 MA 1132.26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 156YK UT WOS:000319860505333 ER PT J AU Woods, AS Colsch, B Jackson, SN Post, J Baldwin, K Roux, A Hoffer, B Cox, BM Hoffer, M Rubovitch, V Pick, CG Schultz, JA Balaban, C AF Woods, Amina S. Colsch, Benoit Jackson, Shelley N. Post, Jeremy Baldwin, Kathrine Roux, Aurelie Hoffer, Barry Cox, Brian M. Hoffer, Michael Rubovitch, Vardit Pick, Chaim G. Schultz, J. Albert Balaban, Carey TI Gangliosides and Ceramides Change in a Mouse Model of Blast Induced Traumatic Brain Injury SO ACS CHEMICAL NEUROSCIENCE LA English DT Article ID TANDEM MASS-SPECTROMETRY; ELECTROSPRAY-IONIZATION; PRESSURE; SYSTEM AB Explosive detonations generate atmospheric pressure changes that produce nonpenetrating blast induced "mild" traumatic brain injury (bTBI). The structural basis for mild bTBI has been extremely controversial. The present study applies matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging to track the distribution of gangliosides in mouse brain tissue that were exposed to very low level of explosive detonations (2.5-5.5 psi peak overpressure). We observed major increases of the ganglioside GM2 in the hippocampus, thalamus, and hypothalamus after a single blast exposure. Moreover, these changes were accompanied by depletion of ceramides. No neurological or brain structural signs of injury could be inferred using standard light microscopic techniques. The first source of variability is generated by the Latency between blast and tissue sampling (peak intensity of the blast wave). These findings suggest that subtle molecular changes in intracellular membranes and plasmalemma compartments may be biomarkers for biological responses to mild bTBI. This is also the first report of a GM2 increase in the brains of mature mice from a nongenetic etiology. C1 [Woods, Amina S.; Colsch, Benoit; Jackson, Shelley N.; Post, Jeremy; Baldwin, Kathrine; Roux, Aurelie] NIDA, IRP, Struct Biol Unit, NIH, Baltimore, MD 21224 USA. [Hoffer, Barry] Case Western Reserve Univ, Cleveland, OH 44106 USA. [Cox, Brian M.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Hoffer, Michael] US Naval Hosp, San Diego, CA USA. [Rubovitch, Vardit; Pick, Chaim G.] Tel Aviv Univ, IL-69978 Tel Aviv, Israel. [Balaban, Carey] Univ Pittsburgh, Pittsburgh, PA USA. [Woods, Amina S.; Post, Jeremy; Cox, Brian M.] Ctr Neurosci & Regenerat Med, Rockville, MD USA. [Schultz, J. Albert] Ionwerks Inc, Houston, TX USA. RP Woods, AS (reprint author), NIDA, IRP, NIH, 333 Cassell Dr,Room 1120, Baltimore, MD 21224 USA. EM awoods@mail.nih.gov OI Balaban, Carey/0000-0002-3570-3844 FU Intramural Research Program of the National Institute on Drug Abuse, NIH; Center for Neuroscience and Regenerative Medicine, Bethesda, MD (Department of Defense) through the Henry M. Jackson Foundation for the Advancement of Military Medicine; Office of National Drug Control Policy (ONDCP); SBIR Phase II NIH-NIDA [1RC3DA031431] FX This research was supported by the Intramural Research Program of the National Institute on Drug Abuse, NIH, and by the Center for Neuroscience and Regenerative Medicine, Bethesda, MD (Department of Defense) through the Henry M. Jackson Foundation for the Advancement of Military Medicine. The authors thank the Office of National Drug Control Policy (ONDCP) for instrumentation funding, without which this and other projects could not have been accomplished. J.A.S. and C.B. acknowledge funding from SBIR Phase II NIH-NIDA grant 1RC3DA031431. NR 24 TC 24 Z9 24 U1 5 U2 41 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1948-7193 J9 ACS CHEM NEUROSCI JI ACS Chem. Neurosci. PD APR PY 2013 VL 4 IS 4 BP 594 EP 600 DI 10.1021/cn300216h PG 7 WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Neurosciences SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Neurosciences & Neurology GA 129VV UT WOS:000317873000009 PM 23590251 ER PT J AU Goodman, PA Li, H Gao, Y Lu, YF Stenger-Smith, JD Redepenning, J AF Goodman, Paul A. Li, H. Gao, Y. Lu, Y. F. Stenger-Smith, J. D. Redepenning, Jody TI Preparation and characterization of high surface area, high porosity carbon monoliths from pyrolyzed bovine bone and their performance as supercapacitor electrodes SO CARBON LA English DT Article ID DOUBLE-LAYER; ACTIVATED CARBONS; IONIC LIQUIDS; CAPACITANCE; GRAPHENE; BEHAVIOR; AEROGELS; FILMS AB Bovine cortical bone was pyrolyzed to produce a network of conductive carbon entwined with native hydroxyapatite that maintains its macroscopic structure during pyrolysis and prevents collapse of the carbon. Self-supporting conductive carbon monoliths were prepared by removing the hydroxyapatite with acid or ethylenediaminetetraacetic acid. The specific surface areas of these monoliths were determined by nitrogen adsorption, and their chemical structure was characterized using Raman spectroscopy. The monoliths exhibit specific surface areas and Raman spectra similar to those of amorphous carbons. Capacitance was assessed using the monoliths as the working electrodes in three-electrode cells, and two-electrode devices in which both electrodes were monoliths. Individual monoliths exhibit specific capacitances of 134 +/- 11 F/g in aqueous solutions of potassium nitrate and 108 +/- 9 F/g in the ionic liquid 1-ethyl-3-methylimidizolium bis(trifluoromethylsulfonyl)imide. The capacitance of individual 6 mm diameter by 1 mm thick electrodes was typically on the order of 0.2 Farads. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Goodman, Paul A.; Li, H.; Redepenning, Jody] Univ Nebraska, Dept Chem, Lincoln, NE 68588 USA. [Gao, Y.; Lu, Y. F.] Univ Nebraska, Dept Elect Engn, Lincoln, NE 68588 USA. [Stenger-Smith, J. D.] USN, Air Warfare Ctr, Div Chem, Weap Div,Res Dept, China Lake, CA 93555 USA. RP Redepenning, J (reprint author), Univ Nebraska, Dept Chem, Lincoln, NE 68588 USA. EM jredepen@unlserve.unl.edu RI Gao, Yang/M-9866-2013 FU Department of Defense Science Mathematics and Research for Transformation (SMART) scholarship program; Nebraska Center for Energy Sciences Research (NCESR); Naval Air Warfare Center Weapons Division ILIR program; NSF through the MRSEC program FX We would like to acknowledge the Department of Defense Science Mathematics and Research for Transformation (SMART) scholarship program for providing a fellowship supporting this work. The Nebraska Center for Energy Sciences Research (NCESR) and the Naval Air Warfare Center Weapons Division ILIR program provided funding. Thank you to Monica Carson-Kinde and Professor Gerald Harbison for help in acquiring and interpreting the solid state NMR spectra. Parts of this work were carried out in the Characterization Facility, University of Minnesota, which receives partial support from NSF through the MRSEC program. Finally, we wish to thank the reviewers for their insights regarding the surface area measurements. NR 39 TC 32 Z9 32 U1 6 U2 143 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0008-6223 J9 CARBON JI Carbon PD APR PY 2013 VL 55 BP 291 EP 298 DI 10.1016/j.carbon.2012.12.066 PG 8 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 105AW UT WOS:000316039000033 ER PT J AU Mokili, JL Dutilh, BE Lim, YW Schneider, BS Taylor, T Haynes, MR Metzgar, D Myers, CA Blair, PJ Nosrat, B Wolfe, ND Rohwer, F AF Mokili, John L. Dutilh, Bas E. Lim, Yan Wei Schneider, Bradley S. Taylor, Travis Haynes, Matthew R. Metzgar, David Myers, Christopher A. Blair, Patrick J. Nosrat, Bahador Wolfe, Nathan D. Rohwer, Forest TI Identification of a Novel Human Papillomavirus by Metagenomic Analysis of Samples from Patients with Febrile Respiratory Illness SO PLOS ONE LA English DT Article ID VIRAL METAGENOMICS; GENE-PRODUCT; DNA; AMPLIFICATION; DATASETS; PLASMID; REGIONS AB As part of a virus discovery investigation using a metagenomic approach, a highly divergent novel Human papillomavirus type was identified in pooled convenience nasal/oropharyngeal swab samples collected from patients with febrile respiratory illness. Phylogenetic analysis of the whole genome and the L1 gene reveals that the new HPV identified in this study clusters with previously described gamma papillomaviruses, sharing only 61.1% (whole genome) and 63.1% (L1) sequence identity with its closest relative in the Papillomavirus episteme (PAVE) database. This new virus was named HPV_SD2 pending official classification. The complete genome of HPV-SD2 is 7,299 bp long (36.3% G/C) and contains 7 open reading frames (L2, L1, E6, E7, E1, E2 and E4) and a non-coding long control region (LCR) between L1 and E6. The metagenomic procedures, coupled with the bioinformatic methods described herein are well suited to detect small circular genomes such as those of human papillomaviruses. C1 [Mokili, John L.; Lim, Yan Wei; Haynes, Matthew R.; Nosrat, Bahador; Rohwer, Forest] San Diego State Univ, Dept Biol, San Diego, CA 92182 USA. [Mokili, John L.; Lim, Yan Wei; Schneider, Bradley S.; Taylor, Travis; Wolfe, Nathan D.] Metabiota, San Francisco, CA USA. [Dutilh, Bas E.] Radboud Univ Nijmegen, Med Ctr, Nijmegen Ctr Mol Life Sci, Ctr Mol & Biomol Informat, NL-6525 ED Nijmegen, Netherlands. [Metzgar, David; Myers, Christopher A.; Blair, Patrick J.] USN, Naval Hlth Res Ctr, San Diego, CA 92152 USA. [Rohwer, Forest] San Diego State Univ, Ctr Microbial Sci, San Diego, CA 92182 USA. RP Mokili, JL (reprint author), San Diego State Univ, Dept Biol, San Diego, CA 92182 USA. EM jmokili@gmail.com RI Valle, Ruben/A-7512-2013; Dutilh, Bas/B-9719-2011; OI Dutilh, Bas/0000-0003-2329-7890; Schneider, Bradley S/0000-0001-7642-0018 FU Dutch Science Foundation (NWO) [016.111.075]; U.S. Department of Defense Global Emerging Infections, Surveillance and Response Systems (DoD GEIS); Defense Threat Reduction Agency (DTRA); Cooperative Biological Engagement Program (CBEP); Google.org; Skoll Foundation; U.S. Agency for International Development (USAID) Emerging Pandemic Threats Program, PREDICT project [GHN-A-OO-09-00010-00] FX BED is supported by the Dutch Science Foundation (NWO) Veni grant (016.111.075). Global Viral Forecasting (JLM, BSS and NDW) was graciously supported by the U.S. Department of Defense Global Emerging Infections, Surveillance and Response Systems (DoD GEIS) and the Defense Threat Reduction Agency (DTRA), Cooperative Biological Engagement Program (CBEP), Google.org, the Skoll Foundation, and the U.S. Agency for International Development (USAID) Emerging Pandemic Threats Program, PREDICT project, under the terms of Cooperative Agreement Number GHN-A-OO-09-00010-00. The Surveillance conducted by Naval Health Research Center (NHRC) was supported by the Global Emerging Infections System division of the Armed Forces Health Surveillance Center. The views expressed in this work are those of the authors and do not reflect the official policy of the Department of the Navy, Department of Defense, or the US Government. Approved for public releases; distribution is unlimited. This research has been conducted in compliance with all applicable federal regulations governing the protection of human subjects in research. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 32 TC 24 Z9 24 U1 0 U2 14 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 15 PY 2013 VL 8 IS 3 AR e58404 DI 10.1371/journal.pone.0058404 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 109ZC UT WOS:000316409800015 PM 23554892 ER PT J AU Conlin, AMS Bukowinski, AT Sevick, CJ DeScisciolo, C Crum-Cianflone, NF AF Conlin, Ava Marie S. Bukowinski, Anna T. Sevick, Carter J. DeScisciolo, Connie Crum-Cianflone, Nancy F. TI Safety of the Pandemic H1N1 Influenza Vaccine Among Pregnant U.S. Military Women and Their Newborns SO OBSTETRICS AND GYNECOLOGY LA English DT Article; Proceedings Paper CT Conference on San Diego Epidemiology Research Exchange CY APR 27, 2012 CL San Diego, CA ID UNITED-STATES; A H1N1; PROSPECTIVE COHORT; OUTCOMES; SURVEILLANCE; VIRUS; RISK AB OBJECTIVES: To assess adverse pregnancy outcomes among active-duty U.S. military women who received pandemic H1N1 vaccine during pregnancy as well as adverse health outcomes among the newborns resulting from these pregnancies. METHODS: The primary study population was a retrospective cohort of active-duty U.S. military women vaccinated during pregnancy with either the pandemic H1N1 vaccine between October 2009 and June 2010 or with seasonal influenza vaccine between October 2008 and June 2009. Rates of pregnancy loss, preeclampsia or eclampsia, and preterm labor were compared between pandemic H1N1 vaccine-exposed (n = 10,376) and seasonal influenza vaccine-exposed pregnancies (n = 7,560). A secondary study population consisted of newborns resulting from these pregnancies. Rates of preterm birth, birth defects, fetal growth problems, and the male-to-female sex ratio were compared between newborns exposed to pandemic H1N1 vaccine and newborns exposed to seasonal influenza vaccine in utero. RESULTS: No significant differences were observed in rates of pregnancy loss (6.4% compared with 6.5%), preeclampsia or eclampsia (5.8% compared with 5.2%), or preterm labor (6.5% compared with 6.2%) between pandemic H1N1 vaccine-exposed and seasonal influenza vaccine-exposed pregnancies. Furthermore, no significant differences were observed in rates of preterm birth (6.2% compared with 6.3%), birth defects (2.1% compared with 2.0%), fetal growth problems (2.6% compared with 2.4%), or the male-to-female sex ratio (1.05 compared with 1.07) between newborns exposed in utero to pandemic H1N1 vaccine compared with seasonal influenza vaccine. Rates of all outcomes were lower or similar to overall general population rates. This study had at least 80% power to detect hazard ratios of 1.18-1.21 or odds ratios of 1.10-1.36, depending on outcome prevalence. CONCLUSION: No adverse pregnancy or newborn health outcomes associated with pandemic H1N1 vaccination during pregnancy were noted among our cohort. These findings should be used to encourage increased vaccine coverage among pregnant women. (Obstet Gynecol 2013;121:511-8) DOI: http://10.1097/AOG.0b013e318280d64e C1 [Conlin, Ava Marie S.; Bukowinski, Anna T.; Sevick, Carter J.; DeScisciolo, Connie; Crum-Cianflone, Nancy F.] NHRC, Deployment Hlth Res Dept, San Diego, CA 92106 USA. RP Conlin, AMS (reprint author), NHRC, 140 Sylvester Rd, San Diego, CA 92106 USA. EM ava.conlin@med.navy.mil NR 32 TC 24 Z9 24 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD MAR PY 2013 VL 121 IS 3 BP 511 EP 518 DI 10.1097/AOG.0b013e318280d64e PG 8 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 112QN UT WOS:000316607600004 PM 23635612 ER PT J AU Mohr, SB Gorham, ED Alcaraz, JE Kane, CI Macera, CA Parsons, JK Wingard, DL Horst, R Garland, CF AF Mohr, Sharif B. Gorham, Edward D. Alcaraz, John E. Kane, Christopher I. Macera, Caroline A. Parsons, J. Kellogg Wingard, Deborah L. Horst, Ronald Garland, Cedric F. TI Serum 25-hydroxyvitamin D and breast cancer in the military: a case-control study utilizing pre-diagnostic serum SO CANCER CAUSES & CONTROL LA English DT Article DE Vitamin D; Breast neoplasms; Case-control studies; 25-hyrdoxyvitamin D; Epidemiology ID VITAMIN-D INTAKE; PLASMA 25-HYDROXYVITAMIN-D; POSTMENOPAUSAL WOMEN; POOLED ANALYSIS; OVARIAN-CANCER; COLON CANCER; RISK; MORTALITY; CALCIUM; 1,25-DIHYDROXYVITAMIN-D AB The objective of this study was to ascertain whether a relationship exists between pre-diagnostic serum levels of 25-hydroxyvitamin D (25(OH)D) and risk of breast cancer in young women. About 600 incident cases of breast cancer were matched to 600 controls as part of a nested case-control study that utilized pre-diagnostic sera. Logistic regression was used to assess the relationship between serum 25(OH)D concentration and breast cancer risk, controlling for race and age. According to the conditional logistic regression for all subjects, odds ratios for breast cancer by quintile of serum 25(OH)D from lowest to highest were 1.2, 1.0, 0.9, 1.1, and 1.0 (reference) (p trend = 0.72). After multivariate regression for subjects whose blood had been collected within 90 days preceding diagnosis, odds ratios for breast cancer by quintile of serum 25(OH)D from lowest to highest were 3.3, 1.9, 1.7, 2.6, and 1.0 (reference) (p trend = 0.09). An inverse association between serum 25(OH)D concentration and risk of breast cancer was not present in the principal analysis, although an inverse association was present in a small subgroup analysis of subjects whose blood had been collected within 90 days preceding diagnosis. Further prospective studies of 25(OH)D and breast cancer risk are needed. C1 [Mohr, Sharif B.; Gorham, Edward D.; Kane, Christopher I.; Wingard, Deborah L.; Garland, Cedric F.] Univ Calif San Diego, Div Epidemiol, Dept Family & Prevent Med, La Jolla, CA 92093 USA. [Mohr, Sharif B.; Gorham, Edward D.; Garland, Cedric F.] Naval Hlth Res Ctr, San Diego, CA 92106 USA. [Alcaraz, John E.; Macera, Caroline A.] San Diego State Univ, Dept Epidemiol & Biostat, San Diego, CA 92182 USA. [Parsons, J. Kellogg] Univ Calif San Diego, Dept Surg, La Jolla, CA 92093 USA. [Horst, Ronald] Heartland Assays, Ames, IA USA. RP Mohr, SB (reprint author), Univ Calif San Diego, Div Epidemiol, Dept Family & Prevent Med, 9500 Gilman Dr 0620, La Jolla, CA 92093 USA. EM sbmohr75@yahoo.com FU Department of the Navy, Bureau of Medicine and Surgery, under Work Unit at the Naval Health Research Center (San Diego, CA, USA) [60126] FX This research was supported by a Congressional allocation to the Penn State Cancer Institute of the Hershey Medical Center, Hershey, PA, through the Department of the Navy, Bureau of Medicine and Surgery, under Work Unit No. 60126 at the Naval Health Research Center (San Diego, CA, USA). The views presented here are solely the opinions of the authors and do not represent an official position of the Department of the Navy, the Department of Defense, or the U.S. Government. Approved for public release; distribution unlimited. Thanks to Dr. Angelee Ferber of the U.S. Army Medical Research and Development Command for providing the blood samples used in this study and for her outstanding support of the research. Thanks to June J. Kim, B. S., of Naval Health Research Center for her valued work editing the manuscript. NR 57 TC 8 Z9 8 U1 1 U2 12 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0957-5243 EI 1573-7225 J9 CANCER CAUSE CONTROL JI Cancer Causes Control PD MAR PY 2013 VL 24 IS 3 BP 495 EP 504 DI 10.1007/s10552-012-0140-6 PG 10 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA 090KC UT WOS:000314976900009 PM 23296455 ER PT J AU Mikheevskiy, S Glinka, G Lee, E AF Mikheevskiy, S. Glinka, G. Lee, E. TI Fatigue Crack Growth Analysis Under Spectrum Loading in Various Environmental Conditions SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE LA English DT Article; Proceedings Paper CT International Symposium on the Environmental Damage under Static and Cyclic Loads in Structural Materials at Ambient Temperatures-II CY AUG 14-19, 2011 CL Krakow, POLAND ID HARDENING MATERIAL; DRIVING-FORCE; TIP; PARAMETERS AB The fatigue process consists, from the engineering point of view, of three stages: crack initiation, fatigue crack growth, and the final failure. It is also known that the fatigue process near notches and cracks is governed by local strains and stresses in the regions of maximum stress and strain concentrations. Therefore, the fatigue crack growth can be considered as a process of successive crack increments, and the fatigue crack initiation and subsequent growth can be modeled as one repetitive process. The assumptions mentioned above were used to derive a fatigue crack growth model based, called later as the UniGrow model, on the analysis of cyclic elastic-plastic stresses-strains near the crack tip. The fatigue crack growth rate was determined by simulating the cyclic stress-strain response in the material volume adjacent to the crack tip and calculating the accumulated fatigue damage in a manner similar to fatigue analysis of stationary notches. The fatigue crack growth driving force was derived on the basis of the stress and strain history at the crack tip and the Smith-Watson-Topper (SWT) fatigue damage parameter, D = sigma(max)Delta epsilon/2. It was subsequently found that the fatigue crack growth was controlled by a two-parameter driving force in the form of a weighted product of the stress intensity range and the maximum stress intensity factor, Delta K (p) K (max) (1-p) . The effect of the internal (residual) stress induced by the reversed cyclic plasticity has been accounted for and therefore the two-parameter driving force made it possible to predict the effect of the mean stress including the influence of the applied compressive stress, tensile overloads, and variable amplitude spectrum loading. It allows estimating the fatigue life under variable amplitude loading without using crack closure concepts. Several experimental fatigue crack growth datasets obtained for the Al 7075 aluminum alloy were used for the verification of the proposed unified fatigue crack growth model. The method can be also used to predict fatigue crack growth under constant amplitude and spectrum loading in various environmental conditions such as vacuum, air, and corrosive environment providing that appropriate limited constant amplitude fatigue crack growth data obtained in the same environment are available. The proposed methodology is equally suitable for fatigue analysis of smooth, notched, and cracked components. C1 [Mikheevskiy, S.; Glinka, G.] Univ Waterloo, Dept Mech Engn, Waterloo, ON N2L 3G1, Canada. [Lee, E.] USN, Air Warfare Ctr, Div Aircraft, Patuxent River, MD 20670 USA. RP Mikheevskiy, S (reprint author), Univ Waterloo, Dept Mech Engn, Waterloo, ON N2L 3G1, Canada. EM smikheev@engmail.uwaterloo.ca RI sebastianovitsch, stepan/G-8507-2013 NR 31 TC 4 Z9 4 U1 1 U2 27 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1073-5623 EI 1543-1940 J9 METALL MATER TRANS A JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci. PD MAR PY 2013 VL 44A IS 3 BP 1301 EP 1310 DI 10.1007/s11661-012-1577-7 PG 10 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 082BK UT WOS:000314366500015 ER PT J AU Ricker, RE Lee, EU Taylor, R Lei, C Pregger, B Lipnickas, E AF Ricker, R. E. Lee, E. U. Taylor, R. Lei, C. Pregger, B. Lipnickas, E. TI Chloride Ion Activity and Susceptibility of Al Alloys 7075-T6 and 5083-H131 to Stress Corrosion Cracking SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE LA English DT Article; Proceedings Paper CT International Symposium on the Environmental Damage under Static and Cyclic Loads in Structural Materials at Ambient Temperatures-II CY AUG 14-19, 2011 CL Krakow, POLAND ID THERMODYNAMIC ACTIVITY QUANTITIES; ALUMINUM-ALLOYS; DISSOLUTION RATES; CLOSED SYSTEMS; AQUEOUS SODIUM; 25-DEGREES-C; COPPER; REEVALUATION; 20-DEGREES-C; PASSIVITY AB The influence of chloride ion activity on the susceptibility of aluminum alloys 5083-H131 and 7075-T6 to stress corrosion cracking (SCC) was investigated by conducting slow strain-rate tensile tests at a strain-rate of 10(-7) s(-1) in naturally aerated aqueous solutions with varying NaCl mass fraction (0.001 to 20 pct) and in a 3.5 pct mass fraction NaCl solution with varying strain-rates (10(-8) to 10(-4) s(-1)). This study found that both alloys exhibited reduced strengths and failure strains (times) in the solutions compared with laboratory air. The extent of these reductions was greater in alloy 5083 for the conditions examined. The strength and ductility of both alloys decreased with chloride ion activity in a manner that indicates a chemical reaction is responsible. The strength and ductility of both alloys decreased with strain-rate in a sigmoidal manner, but the transition in alloy 7075 occurred at slower strain-rates of approximately two orders of magnitude. It was deduced that the chloride ion interacts chemically with the passivated surface in the potential gradient at the crack tip to cause SCC. While no mechanism of cracking can be eliminated on the basis of these results alone, the results are consistent with the hypothesis that the absorbed hydrogen causes cracking in alloy 7075 while cracking in 5083 is the result of a dissolution mechanism. C1 [Ricker, R. E.] NIST, Mat Sci & Engn Div, Gaithersburg, MD 20899 USA. [Lee, E. U.; Taylor, R.; Lei, C.; Pregger, B.; Lipnickas, E.] USN, Mat Engn Div, Air Warfare Ctr, Div Aircraft, Patuxent River, MD 20670 USA. RP Ricker, RE (reprint author), NIST, Mat Sci & Engn Div, Gaithersburg, MD 20899 USA. EM eun.lee@navy.mil RI Ricker, Richard/H-4880-2011 OI Ricker, Richard/0000-0002-2871-4908 FU Office of Naval Research at the Naval Air Systems Command [N0001412AF00002] FX The authors would like to thank the Office of Naval Research for supporting this investigation at the Naval Air Systems Command (Reference No. N0001412AF00002). Special thanks are due to Drs. R. Williams and A. K. Vasudevan, and Mr. W. C. Nickerson for monitoring and providing technical guidance to this study. NR 59 TC 9 Z9 13 U1 1 U2 29 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1073-5623 EI 1543-1940 J9 METALL MATER TRANS A JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci. PD MAR PY 2013 VL 44A IS 3 BP 1353 EP 1364 DI 10.1007/s11661-012-1500-2 PG 12 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 082BK UT WOS:000314366500020 ER PT J AU Littman, AJ Jacobson, IG Boyko, EJ Powell, TM Smith, TC AF Littman, A. J. Jacobson, I. G. Boyko, E. J. Powell, T. M. Smith, T. C. CA Millennium Cohort Study Team TI Weight change following US military service SO INTERNATIONAL JOURNAL OF OBESITY LA English DT Article DE military veterans; weight gain; prospective; cohort; posttraumatic stress disorder; military deployment ID VETERANS; OBESITY; COHORT; OVERWEIGHT; VALIDITY; BURDEN AB BACKGROUND: Although overweight and obesity are less prevalent among active-duty military personnel compared with similar persons not serving in the military, no such differences have been observed between veterans and non-veterans. OBJECTIVES: To assess the magnitude of weight changes before, concurrent with and following discharge from the military, relative to weight during service, and to determine the demographic, service-related and psychological characteristics associated with clinically important weight gain among those who were discharged from military service during follow-up. METHODS: Eligible Millennium Cohort Study participants (n = 38 686) completed the questionnaires approximately every 3 years (2001, 2004 and 2007) that were used to estimate annual weight changes, as well as the percentage experiencing clinically important weight gain, defined as >= 10%. Analyses were stratified by sex. RESULTS: Weight gain was greatest around the time of discharge from service and in the 3 years before discharge (1.0-1.3 kg per year), while it was nearly half as much during service (0.6-0.7 kg per year) and >= 3 years after service ended (0.7 kg per year). Consequently, 6-year weight gain was over 2 kg greater in those who were discharged compared with those who remained in the military during follow-up (5.7 vs 3.5 kg in men; 6.3 vs 4.0 kg in women). In those who were discharged, younger age, less education, being overweight at baseline, being in the active-duty component (vs Reserve/National Guard) and having experienced deployment with combat exposures (vs non-deployment) were associated with increased risks of clinically important weight gain. CONCLUSIONS: This study provides the first prospectively collected evidence for an increased rate of weight gain around the time of military discharge that may explain previously reported higher rates of obesity in veterans, and identifies characteristics of higher-risk groups. Discharge from military service presents a window of risk and opportunity to prevent unhealthy weight gain in military personnel and veterans. International Journal of Obesity (2013) 37, 244-253; doi:10.1038/ijo.2012.46; published online 10 April 2012 C1 [Littman, A. J.; Boyko, E. J.] Vet Affairs Puget Sound Hlth Care Syst, Seattle Epidemiol Res & Informat Ctr, Seattle, WA USA. [Littman, A. J.] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA. [Jacobson, I. G.; Powell, T. M.; Smith, T. C.] USN, Dept Deployment Hlth Res, Hlth Res Ctr, San Diego, CA 92152 USA. RP Littman, AJ (reprint author), Vet Affairs Puget Sound Hlth Care Syst 152E, Seattle Epidemiol Res & Informat Ctr, 1100 Olive Way,Suite 1400, Seattle, WA 98101 USA. EM alyson@u.washington.edu FU Henry M Jackson Foundation for the Advancement of Military Medicine, Rockville, MD; VA Rehabilitation Research and Development Career Development Award [6982]; Cooperative Studies Program, Department of Veterans; Puget Sound VA Medical Center; Department of Defense [60002] FX We are indebted to the Millennium Cohort Study participants, without whom these analyses would not be possible. In addition to the authors, the Millennium Cohort Study Team includes Paul J Amoroso, MD; Gary D Gackstetter, MD, from the Analytic Services, Inc., Arlington, VA; Gregory C Gray, MD, MPH, from the College of Public Health and Health Professions, University of Florida, Gainesville, FL; Tomoko Hooper, MD, from the Departments of Preventive Medicine and Biometrics, Uniformed Services University of Health Sciences, Bethesda, MD; James R Riddle, DVM, MPH, from the Air Force Research Laboratory, Wright-Patterson Air Force Base, OH; Margaret AK Ryan, MD, MPH, from Naval Hospital Camp Pendleton, Occupational Health Department; Melissa Bagnell, MPH; Nancy Crum-Cianflone, MD, MPH; Gia Gumbs, MPH; Nisara Granado, MPH, PhD; Jaime Horton; Kelly Jones, MPH; Cynthia LeardMann, MPH; William Lee; Travis Leleu; Michelle Linfesty; Gordon Lynch; Jamie McGrew; Hope McMaster, PhD; Sheila Medina-Torne, MPH; Amanda Pietrucha, MPH; Donald Sandweiss, MD; Amber Seelig, MPH; Beverly Sheppard; Katherine Snell; Steven Speigle; Kari Sausedo, MA; Donald Slymen, PhD; Besa Smith, MPH, PhD; Jennifer Walstrom; Timothy S Wells, DVM, MPH, PhD; Martin White, MPH; James Whitmer; and Charlene Wong, MPH; from the Department of Deployment Health Research, Naval Health Research Center, San Diego, CA. We thank Scott L Seggerman and Greg D Boyd from the Management Information Division, Defense Manpower Data Center, Monterey, CA. Additionally, we thank Michelle LeWark from the Naval Health Research Center. We also thank all the professionals from the US Army Medical Research and Materiel Command, especially those from the Military Operational Medicine Research Program, Fort Detrick, MD. We appreciate the support of the Henry M Jackson Foundation for the Advancement of Military Medicine, Rockville, MD. Dr Littman was supported by a VA Rehabilitation Research and Development Career Development Award (#6982).; The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of the Army, Department of the Air Force, Department of Defense, Department of Veterans Affairs or the US Government. This material is the result of work partly supported with resources and the use of facilities from the Cooperative Studies Program, Department of Veterans and the Puget Sound VA Medical Center. This work represents report 0934, supported by the Department of Defense, under work unit no. 60002. This research has been conducted in compliance with all applicable federal regulations governing the protection of human subjects in research (Protocol NHRC.2000.007). NR 21 TC 11 Z9 11 U1 1 U2 7 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0307-0565 J9 INT J OBESITY JI Int. J. Obes. PD FEB PY 2013 VL 37 IS 2 BP 244 EP 253 DI 10.1038/ijo.2012.46 PG 10 WC Endocrinology & Metabolism; Nutrition & Dietetics SC Endocrinology & Metabolism; Nutrition & Dietetics GA 117DK UT WOS:000316932100014 PM 22491091 ER PT J AU Chiodi, F Witt, JDS Smits, RGJ Qu, L Halasz, GB Wu, CT Valls, OT Halterman, K Robinson, JWA Blamire, MG AF Chiodi, F. Witt, J. D. S. Smits, R. G. J. Qu, L. Halasz, Gabor B. Wu, C-T Valls, O. T. Halterman, K. Robinson, J. W. A. Blamire, M. G. TI Supra-oscillatory critical temperature dependence of Nb-Ho bilayers SO EPL LA English DT Article ID FERROMAGNET; SUPERCURRENT; MULTILAYERS AB We investigate the critical temperature T-c of a thin s-wave superconductor (Nb) proximity coupled to a helical rare-earth ferromagnet (Ho). As a function of the Ho layer thickness, we observe multiple oscillations of T-c superimposed on a slow decay, that we attribute to the influence of the Ho on the Nb proximity effect. Because of the inhomogeneous magnetization in Ho, singlet and triplet pair correlations are present in the bilayers. We take both into consideration when solving the self-consistent Bogoliubov-de Gennes equations, and we find a reasonable agreement with the experiments. We also observe non-trivial transitions into the superconducting state, the zero resistance state being attained after two successive transitions which appear to be associated with the magnetic structure of Ho. Copyright (c) EPLA, 2013 C1 [Chiodi, F.; Smits, R. G. J.; Qu, L.; Halasz, Gabor B.; Robinson, J. W. A.; Blamire, M. G.] Univ Cambridge, Dept Mat Sci & Met, Cambridge CB2 3QZ, England. [Chiodi, F.] Univ Paris 11, Inst Elect Fondamentale, CNRS, F-91405 Orsay, France. [Witt, J. D. S.] Univ Leeds, Sch Phys & Astron, EC Stoner Lab, Leeds LS2 9JT, W Yorkshire, England. [Wu, C-T; Valls, O. T.] Univ Minnesota, Sch Phys & Astron, Minneapolis, MN 55455 USA. [Halterman, K.] USN, Michelson Lab, Div Phys, Air Warfare Ctr, China Lake, CA 93555 USA. [Valls, O. T.] Univ Minnesota, Minnesota Supercomp Inst, Minneapolis, MN 55455 USA. RP Chiodi, F (reprint author), Univ Cambridge, Dept Mat Sci & Met, Pembroke St, Cambridge CB2 3QZ, England. EM francesca.chiodi@u-psud.fr; jjr33@cam.ac.uk FU UK EPSRC; Royal Society through a University research Fellowship; IARPA grant [N66001-12-1-2023] FX This work was funded by the UK EPSRC and the Royal Society through a University research Fellowship. OTV and CTW thank IARPA grant N66001-12-1-2023 for partial support. NR 31 TC 13 Z9 13 U1 0 U2 16 PU EPL ASSOCIATION, EUROPEAN PHYSICAL SOCIETY PI MULHOUSE PA 6 RUE DES FRERES LUMIERE, MULHOUSE, 68200, FRANCE SN 0295-5075 J9 EPL-EUROPHYS LETT JI EPL PD FEB PY 2013 VL 101 IS 3 AR 37002 DI 10.1209/0295-5075/101/37002 PG 5 WC Physics, Multidisciplinary SC Physics GA 096KH UT WOS:000315402200023 ER PT J AU Bartlett, JL Sessoms, PH Reini, SA AF Bartlett, Jamie L. Sessoms, Pinata H. Reini, Seth A. TI Strength Through Science: Using Virtual Technology to Advance the Warfighter SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Editorial Material ID TREADMILL WALKING C1 [Bartlett, Jamie L.; Sessoms, Pinata H.; Reini, Seth A.] USN, Warfighter Performance Dept, Hlth Res Ctr, San Diego, CA 92152 USA. RP Bartlett, JL (reprint author), USN, Warfighter Performance Dept, Hlth Res Ctr, San Diego, CA 92152 USA. RI Bartlett, Jamie/B-9756-2014 OI Bartlett, Jamie/0000-0001-7934-7119 NR 5 TC 2 Z9 2 U1 0 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD FEB PY 2013 VL 84 IS 2 BP 165 EP 166 DI 10.3357/ASEM.3578.2013 PG 2 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 079VO UT WOS:000314200500013 PM 23447856 ER PT J AU Melcer, T Walker, GJ Sechriest, VF Galarneau, M Konoske, P Pyo, J AF Melcer, Ted Walker, G. Jay Sechriest, V. Franklin Galarneau, Michael Konoske, Paula Pyo, Jay TI Short-Term Physical and Mental Health Outcomes for Combat Amputee and Nonamputee Extremity Injury Patients SO JOURNAL OF ORTHOPAEDIC TRAUMA LA English DT Article DE blast injury; combat amputee; extremity injury; postinjury infections; mental health diagnoses; posttraumatic stress disorder ID POSTTRAUMATIC-STRESS-DISORDER; ENDURING FREEDOM; IRAQ; INFECTIONS; RISK AB Objectives: The present study: (1) reports the early physical health complications, mental health outcomes, and outpatient health care utilization of patients with serious extremity injuries sustained during the Iraq or Afghanistan wars and (2) compares clinical outcomes between amputee and nonamputee extremity injury groups. Method: This was a retrospective review of clinical records in military health databases for patients injured in the Iraq and Afghanistan wars. Health outcomes of amputee (n = 382, injured 2001-2005) and nonamputee patients (n = 274, injured 2001-2007) with serious extremity injuries (abbreviated injury score >= 3) were followed up to 24 months post injury. This study was performed at Naval Health Research Center, San Diego. Results: Amputee and nonamputee groups had similar injury severity scores. Amputees had nearly double the risk of certain adverse complications (infections, anemia, septicemia, and thromboembolic disease), but other complications (osteomyelitis and nonhealing wound) were similar between the 2 groups. Amputees had significantly greater odds of certain mental health disorders including mood, sleep, pain, and postconcussion syndrome. However, amputees had significantly reduced odds of posttraumatic stress disorder compared with nonamputees. Amputees used various outpatient clinics significantly more than nonamputees. Conclusions: Patients with serious combat extremity injuries showed high rates of adverse health outcomes in the short term. Amputees had higher rates of many but not all clinically important physical and mental health outcomes compared to nonamputees. These results are important for military orthopaedic surgeons and allied providers who care for and counsel these patients and clinicians and researchers who seek to understand and improve health outcomes in patients with extremity war injuries. C1 [Melcer, Ted; Galarneau, Michael; Konoske, Paula] USN, Med Modeling Simulat & Miss Support Dept, Hlth Res Ctr, San Diego, CA 92106 USA. [Walker, G. Jay] Sci Applicat Int Corp, Mclean, VA 22102 USA. [Sechriest, V. Franklin] USN, Dept Orthoped Surg, San Diego Med Ctr, San Diego, CA 92106 USA. [Pyo, Jay] USN, Comprehens Complex Casualty Care Ctr, San Diego Med Ctr, San Diego, CA 92106 USA. RP Melcer, T (reprint author), USN, Med Modeling Simulat & Miss Support Dept, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. EM ted.melcer@med.navy.mil FU Office of the Assistant Secretary of Defense (Health Affairs), US Army Medical Research and Materiel Command, Marine Corps Systems Command; Office of Naval Research: NHRC Work Unit [60332]; Office of Naval Research, Arlington, VA [60332] FX Supported by Office of the Assistant Secretary of Defense (Health Affairs), US Army Medical Research and Materiel Command, Marine Corps Systems Command, and the Office of Naval Research: NHRC Work Unit: 60332. Report No. 10-24 was supported by the Office of Naval Research, Arlington, VA, under Work Unit No. 60332. NR 21 TC 10 Z9 10 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0890-5339 J9 J ORTHOP TRAUMA JI J. Orthop. Trauma PD FEB PY 2013 VL 27 IS 2 BP E31 EP E37 DI 10.1097/BOT.0b013e3182517e1c PG 7 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 077VV UT WOS:000314058300002 PM 22495531 ER PT J AU Taylor, MK Pietrobon, R Taverniers, J Leon, MR Fern, BJ AF Taylor, Marcus K. Pietrobon, Ricardo Taverniers, John Leon, Matthew R. Fern, Benedict J. TI Relationships of hardiness to physical and mental health status in military men: a test of mediated effects SO JOURNAL OF BEHAVIORAL MEDICINE LA English DT Article DE Hardiness; Health; Mediated effects; Mental health; Physical health ID RESILIENCE INTERVENTION; PERSONALITY CONSTRUCT; PROTECTIVE FACTORS; COPING STRATEGIES; JOB-SATISFACTION; LIFE EVENTS; STRESS; ILLNESS; PREDICTORS; SUPPORT AB Evidence links the personality trait hardiness to both mental (MH) and physical health (PH) status, but few unifying models delineate interrelationships of these variables. The first purpose of this study was to examine the association of hardiness to MH and PH in military men. Second, we tested the hypothesis that MH would mediate the association of hardiness with PH. Identical measures were collected in two separate, demographically-similar samples (n = 65 and n = 55). All subjects completed a background questionnaire, the Dispositional Resilience Scale-15 and the Short Form 36 Medical Outcomes Survey. Associations between hardiness, PH and MH were examined using regression-based mediation analyses followed by the Sobel test of indirect effects. In the total sample, hardiness predicted PH in an initial regression model (beta = 0.37, p < .001). When MH was added to the model, however, PH's influence was substantially attenuated and no longer significant (beta = 0.06, p > .05). A Sobel test of significance confirmed a mediated effect (p < .001). Similar patterns were observed in each individual sample. Hardiness is associated with PH in military men, and this relationship is mediated by MH. C1 [Taylor, Marcus K.] USN, Dept Behav Sci & Epidemiol, Hlth Res Ctr, San Diego, CA 92152 USA. [Pietrobon, Ricardo] Duke Univ, Med Ctr, Dept Anesthesiol, Durham, NC 27710 USA. [Pietrobon, Ricardo] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA. [Taverniers, John] Open Univ Netherlands, Fac Psychol, Heerlen, Netherlands. [Taverniers, John] Royal Mil Acad, Dept Behav Sci, Brussels, Belgium. [Leon, Matthew R.; Fern, Benedict J.] USN, Operat Stress & Resilience Program, Aeromed Res Directorate, Aerosp Med Res Lab, Pensacola, FL USA. RP Taylor, MK (reprint author), USN, Dept Behav Sci & Epidemiol, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92152 USA. EM marc.taylor@med.navy.mil NR 72 TC 10 Z9 10 U1 2 U2 22 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0160-7715 J9 J BEHAV MED JI J. Behav. Med. PD FEB PY 2013 VL 36 IS 1 BP 1 EP 9 DI 10.1007/s10865-011-9387-8 PG 9 WC Psychology, Clinical SC Psychology GA 068KT UT WOS:000313366300001 PM 22108762 ER PT J AU Ganesan, A Krantz, EM Hullsiek, KH Riddle, MS Weintrob, AC Lalani, T Okulicz, JF Landrum, M Agan, B Whitman, TJ Ross, MJ Crum-Cianflone, NF AF Ganesan, A. Krantz, E. M. Hullsiek, K. Huppler Riddle, M. S. Weintrob, A. C. Lalani, T. Okulicz, J. F. Landrum, M. Agan, B. Whitman, T. J. Ross, M. J. Crum-Cianflone, N. F. CA Infect Dis Clinical Res Program TI Determinants of incident chronic kidney disease and progression in a cohort of HIV-infected persons with unrestricted access to health care SO HIV MEDICINE LA English DT Article DE baseline CD4 count; ethnicity; highly active antiretroviral therapy; HIV infection; kidney disease; socioeconomic status ID STAGE RENAL-DISEASE; GLOMERULAR-FILTRATION-RATE; ACTIVE ANTIRETROVIRAL THERAPY; ATHEROSCLEROSIS RISK; RACIAL-DIFFERENCES; NEPHROPATHY; SPECTRUM; RECOMMENDATIONS; ASSOCIATION; COMMUNITIES AB Objectives As socioeconomic factors may impact the risk of chronic kidney disease (CKD), we evaluated the incidence and risk factors of incident CKD among an HIV-infected cohort with universal access to health care and minimal injecting drug use (IDU). Methods Incident CKD was defined as an estimated glomerular filteration rate (eGFR) <60?ml/min/1.73?m2 for =?90 days. eGFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Rates were calculated per 1000 person-years (PY). Associations with outcomes were assessed using two separate Cox proportional hazard models, adjusting for baseline and time-updated covariates. Results Among 3360 participants [median age 29 years; 92% male; 44% African American (AA)] contributing 23?091 PY of follow-up, 116 developed incident CKD [5.0/1000 PY; 95% confidence interval (CI) 4.26.0/1000 PY]. The median first eGFR value was 97.0?mL/min/1.73?m2 [interquartile range (IQR) 85.3110.1?mL/min/1.73?m2]. Baseline factors associated with CKD included older age, lower CD4 count at HIV diagnosis [compared with CD4 count =?500 cells/mu L, hazard ratio (HR) 2.1 (95% CI 1.23.8) for CD4 count 350499 cells/mu L; HR 3.6 (95% CI 2.06.3) for CD4 count 201349 cells/mu L; HR 4.3 (95% CI 2.09.4) for CD4 count =?200 cells/mu L], and HIV diagnosis in the pre-highly active antiretroviral therapy (HAART) era. In the time-updated model, low nadir CD4 counts, diabetes, hepatitis B, hypertension and less HAART use were also associated with CKD. AA ethnicity was not associated with incident CKD in either model. Conclusions The low incidence of CKD and the lack of association with ethnicity observed in this study may in part be attributable to unique features of our cohort such as younger age, early HIV diagnosis, minimal IDU, and unrestricted access to care. Lower baseline CD4 counts were significantly associated with incident CKD, suggesting early HIV diagnosis and timely introduction of HAART may reduce the burden of CKD. C1 [Ganesan, A.; Krantz, E. M.; Hullsiek, K. Huppler; Weintrob, A. C.; Lalani, T.; Okulicz, J. F.; Landrum, M.; Agan, B.; Whitman, T. J.; Crum-Cianflone, N. F.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Ganesan, A.] Natl Naval Med Ctr, Div Infect Dis, Bethesda, MD 20889 USA. [Krantz, E. M.; Hullsiek, K. Huppler] Univ Minnesota, Minneapolis, MN USA. [Weintrob, A. C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Lalani, T.] USN, Med Ctr Portsmouth, Portsmouth, VA USA. [Okulicz, J. F.; Landrum, M.] San Antonio Mil Med Ctr, San Antonio, TX USA. [Ross, M. J.] Mt Sinai Sch Med, New York, NY USA. [Crum-Cianflone, N. F.] USN, San Diego Med Ctr, San Diego, CA 92152 USA. [Crum-Cianflone, N. F.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. RP Ganesan, A (reprint author), Natl Naval Med Ctr, Div Infect Dis, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM anuradha.ganesan@med.navy.mil OI Polis, Michael/0000-0002-9151-2268; Agan, Brian/0000-0002-5114-1669 FU Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) programme executed through the Uniformed Services University of the Health Sciences [IDCRP-015]; National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) [Y1-AI-5072] FX We would like to thank the participants and their caregivers, without whom none of this work would be possible. We would also like to thank the research coordinators and support staff who have diligently worked on the Department of Defense HIV Natural History Study, as well as the members of the Infectious Disease Clinical Research Program HIV Working Group, listed in the Appendix. Support for this work (IDCRP-015) was provided by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) programme executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072. NR 42 TC 8 Z9 8 U1 0 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1464-2662 J9 HIV MED JI HIV Med. PD FEB PY 2013 VL 14 IS 2 BP 65 EP 76 DI 10.1111/j.1468-1293.2012.01036.x PG 12 WC Infectious Diseases SC Infectious Diseases GA 063KV UT WOS:000312998300001 PM 22808988 ER PT J AU Sprouse, C Tosi, L Lipof, J Abdel-Ghani, M Clifford, H Norrell, K Leo, N Rentas, V Gordish-Dressman, H Devaney, J Kelly, K AF Sprouse, Courtney Tosi, Laura Lipof, Jason Abdel-Ghani, Mai Clifford, Hugo Norrell, Kirsten Leo, Nathanael Rentas, Victoria Gordish-Dressman, Heather Devaney, Joseph Kelly, Karen TI CKMM Polymorphism Is Associated with Physical Fitness Test Scores In Military Recruits SO JOURNAL OF BONE AND MINERAL RESEARCH LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Bone-and-Mineral-Research CY OCT 04-07, 2013 CL Baltimore, MD SP Amer Soc Bone & Mineral Res C1 [Sprouse, Courtney; Tosi, Laura; Gordish-Dressman, Heather; Devaney, Joseph] Childrens Natl Med Ctr, Washington, DC USA. [Lipof, Jason; Clifford, Hugo; Norrell, Kirsten; Leo, Nathanael] George Washington Univ, Washington, DC 20052 USA. [Abdel-Ghani, Mai] George Mason Univ, Fairfax, VA 22030 USA. [Rentas, Victoria] Howard Univ, Washington, DC USA. [Kelly, Karen] Naval Hlth Res, San Diego, CA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0884-0431 EI 1523-4681 J9 J BONE MINER RES JI J. Bone Miner. Res. PD FEB PY 2013 VL 28 SU 1 MA SA0194 PG 3 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA AB8JI UT WOS:000332035803107 ER PT J AU Trone, DW Cipriani, DJ Raman, R Wingard, DL Shaffer, RA Macera, CA AF Trone, Daniel W. Cipriani, Daniel J. Raman, Rema Wingard, Deborah L. Shaffer, Richard A. Macera, Caroline A. TI The Association of Self-Reported Measures With Poor Training Outcomes Among Male and Female U.S. Navy Recruits SO MILITARY MEDICINE LA English DT Article ID EXERCISE-RELATED INJURIES; STRESS-FRACTURES; RISK-FACTORS; MUSCULOSKELETAL INJURIES; YOUNG MEN; MENSTRUAL IRREGULARITY; PHYSICAL-ACTIVITY; BONE-DENSITY; ARMY; PREDICTORS AB This prospective study evaluated the association of self-reported health habits and behaviors in 2,930 Navy recruits with poor training outcomes, defined as graduating late or separating from training. Although 17% of the men and 21% of the women had a poor training outcome, results suggest that some self-reported measures were associated with poor training outcomes. Men who did not run or jog at least 1 month before basic training or had a previous lower limb injury without complete recovery and women reporting the same or less physical activity compared with their same-age counterparts were more likely to have a poor training outcome. An important first step in decreasing poor training outcomes is encouraging incoming recruits to participate in physical activity and taking steps to identify and rehabilitate recruits who are not completely healed from a lower limb musculoskeletal injury before reporting to basic training. C1 [Trone, Daniel W.; Shaffer, Richard A.; Macera, Caroline A.] Naval Hlth Res Ctr, Dept Behav Sci & Epidemiol, San Diego, CA 92106 USA. [Trone, Daniel W.; Wingard, Deborah L.] Univ Calif San Diego, Dept Family & Prevent Med, Div Epidemiol, La Jolla, CA 92093 USA. [Trone, Daniel W.; Macera, Caroline A.] San Diego State Univ, Grad Sch Publ Hlth, San Diego, CA 92182 USA. [Cipriani, Daniel J.] Chapman Univ, Dept Phys Therapy, Orange, CA 92866 USA. [Raman, Rema] Univ Calif San Diego, Dept Family & Prevent Med, Div Biostat & Bioinformat, La Jolla, CA 92093 USA. RP Trone, DW (reprint author), Naval Hlth Res Ctr, Dept Behav Sci & Epidemiol, 140 Sylvester Rd, San Diego, CA 92106 USA. NR 34 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JAN PY 2013 VL 178 IS 1 BP 43 EP 49 DI 10.7205/MILMED-D-12-00271 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA AN7TV UT WOS:000340804800013 PM 23356118 ER PT J AU Taylor, MK AF Taylor, Marcus K. TI Dehydroepiandrosterone and Dehydroepiandrosterone Sulfate: Anabolic, Neuroprotective, and Neuroexcitatory Properties in Military Men SO MILITARY MEDICINE LA English DT Article ID SALIVARY ALPHA-AMYLASE; TRAUMATIC BRAIN-INJURY; ADRENERGIC ACTIVITY; STRESS; RECEPTOR; CORTICOSTERONE; DHEA; HIPPOCAMPAL; RAT; METABOLITES AB Evidence links dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) to crucial military health issues, including operational stress, resilience, and traumatic brain injury. This study evaluated the anabolic, neuroprotective, and neuroexcitatory properties of DHEA(S) in healthy military men. A salivary sample was obtained from 42 men and assayed for DHEA(S), testosterone, nerve growth factor (NGF; which supports nerve cell proliferation), and salivary alpha amylase (sAA; a proxy of sympathetic nervous system function). Separate regression analyses were conducted with DHEA and DHEAS as independent variables, and testosterone, NGF, and sAA as dependent variables, respectively. The models explained 23.4% of variance in testosterone (p < 0.01), 17.2% of variance in NGF (p < 0.01), and 7.4% of variance in sAA (p = 0.09). Standardized beta coefficients revealed that DHEA independently influenced testosterone (beta = 0.40, p < 0.01), whereas DHEAS independently influenced NGF (beta = 0.48, p < 0.01) and sAA (beta = 0.36, p < 0.05). DHEA demonstrated anabolic properties, whereas DHEAS demonstrated neuroprotective and neuroexcitatory properties in military men. This area of study has broad implications for stress inoculation, traumatic brain injury rehabilitation, and regenerative medicine in military personnel. C1 Naval Hlth Res Ctr, Dept Behav Sci & Epidemiol, Behav Sci Lab, San Diego, CA 92106 USA. RP Taylor, MK (reprint author), Naval Hlth Res Ctr, Dept Behav Sci & Epidemiol, Behav Sci Lab, San Diego, CA 92106 USA. FU Office of Naval Research [PB401] FX The author would like to thank Michelle LeWark for her editorial expertise. This work was supported by the Office of Naval Research, under Work Unit No. PB401. NR 33 TC 10 Z9 11 U1 1 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JAN PY 2013 VL 178 IS 1 BP 100 EP 106 DI 10.7205/MILMED-D-12-00296 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA AN7TV UT WOS:000340804800022 PM 23356127 ER PT S AU Illig, DW Jemison, WD Rumbaugh, L Lee, R Laux, A Mullen, L AF Illig, David W. Jemison, William D. Rumbaugh, Luke Lee, Robert Laux, Alan Mullen, Linda GP IEEE TI Enhanced hybrid lidar-radar ranging technique SO 2013 OCEANS - SAN DIEGO SE OCEANS-IEEE LA English DT Proceedings Paper CT MTS/IEEE Oceans Conference CY SEP 23-27, 2013 CL San Diego, CA SP IEEE, Marine Technol Soc, IEEE Oceanic Engn Soc, Newfoundland Labrador, Seacon, UC San Diego, Scripps Inst Oceanog DE underwater; optical; ranging; scattering ID FREQUENCY-DOMAIN REFLECTOMETRY AB A new hybrid lidar-radar underwater ranging technique is presented to enhance optical ranging in underwater environments. This technique has the potential to extend the unambiguous range by an order of magnitude while maintaining range precision that is comparable to existing techniques. The technique combines frequency domain reflectometry (FDR) [1] and modulated continuous wave (CW) ranging [2] to simultaneously achieve good unambiguous range and range precision performance. Theory and simulation are presented to demonstrate the FDR and combined FDR/CW approach. These results indicate that for the system parameters chosen the combined FDR/CW approach can extend the unambiguous range from tens of centimeters to approximately ten meters depending on water turbidity while maintaining the range precision associated with the CW approach. C1 [Illig, David W.; Jemison, William D.; Rumbaugh, Luke] Clarkson Univ, Dept Elect & Comp Engn, Potsdam, NY 13699 USA. [Lee, Robert; Laux, Alan; Mullen, Linda] NAVAIR, Div EO & Special Mission Sensors, Patuxent River, MD 20670 USA. RP Illig, DW (reprint author), Clarkson Univ, Dept Elect & Comp Engn, Potsdam, NY 13699 USA. EM illigdw@clarkson.edu FU Office of Naval Research's University Laboratory Initiative (ULI) [N00014-11-1-0371] FX This work is supported by the Office of Naval Researchs University Laboratory Initiative (ULI) program contract number N00014-11-1-0371. Any opinions, findings and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the Office of Naval Research. NR 14 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0197-7385 BN 978-0-933957-40-4 J9 OCEANS-IEEE PY 2013 PG 9 WC Engineering, Marine; Oceanography SC Engineering; Oceanography GA BA3ER UT WOS:000334165800017 ER PT S AU Kothe, CA Makeig, S Onton, JA AF Kothe, Christian Andreas Makeig, Scott Onton, Julie Anne GP IEEE TI Emotion Recognition from EEG During Self-Paced Emotional Imagery SO 2013 HUMAINE ASSOCIATION CONFERENCE ON AFFECTIVE COMPUTING AND INTELLIGENT INTERACTION (ACII) SE International Conference on Affective Computing and Intelligent Interaction LA English DT Proceedings Paper CT 5th Biannual Conference of the Humaine-Association on Affective Computing and Intelligent Interaction (ACII) CY SEP 02-05, 2013 CL Geneva, SWITZERLAND SP Humaine Assoc, IEEE Comp Soc, Comp Vis, Multimedia Lab, Univ Geneva, Swiss Ctr Affect Sci, GFK Verein, Technicolor, Telono, Brain Prod, Inst Telecom, Telecom ParisTech, Swiss Natl Sci Fdn, Soc Academique Geneve, Amer Assoc Artificial Intelligence DE emotion; valence; brain-computer interface; EEG; machine learning; guided imagery AB Here we present an analysis of a 12-subject electroencephalographic (EEG) data set in which participants were asked to engage in prolonged, self-paced episodes of guided emotion imagination with eyes closed. Our goal is to correctly predict, given a short EEG segment, whether the participant was imagining a positive respectively negative-valence emotional scenario during the given segment using a predictive model learned via machine learning. The challenge lies in generalizing to novel (i.e., previously unseen) emotion episodes from a wide variety of scenarios including love, awe, frustration, anger, etc. based purely on spontaneous oscillatory EEG activity without stimulus event-locked responses. Using a variant of the Filter-Bank Common Spatial Pattern algorithm, we achieve an average accuracy of 71.3% correct classification of binary valence rating across 12 different emotional imagery scenarios under rigorous block-wise cross-validation. C1 [Kothe, Christian Andreas; Makeig, Scott] Univ Calif San Diego, Swartz Ctr Computat Neurosci, La Jolla, CA 92093 USA. [Onton, Julie Anne] Naval Hlth Res Ctr, San Diego, CA 92152 USA. RP Kothe, CA (reprint author), Univ Calif San Diego, Swartz Ctr Computat Neurosci, La Jolla, CA 92093 USA. EM christian@sccn.ucsd.edu; scott@sccn.ucsd.edu; julie.onton@med.navy.mil FU The Swartz Foundation (Old Field, NY); National Institute for Mental Health USA [R01 NS074293]; National Science Foundation USA [IIS-0613595] FX This work was supported by a gift from The Swartz Foundation (Old Field, NY) as well as by grants from the National Institute for Mental Health USA (R01 NS074293) and the National Science Foundation USA (IIS-0613595). NR 17 TC 7 Z9 7 U1 1 U2 8 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2156-8103 BN 978-0-7695-5048-0 J9 INT CONF AFFECT PY 2013 BP 855 EP 858 DI 10.1109/ACII.2013.160 PG 4 WC Computer Science, Artificial Intelligence; Computer Science, Information Systems; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BA2RH UT WOS:000333833400155 ER PT J AU Carpenter, RJ Refugio, ON Adams, N O'Brien, KP Johnson, MD Groff, HL Maves, RC Bavaro, MF Crum-Cianflone, NF AF Carpenter, Robert J. Refugio, Oliver N. Adams, Nehkonti O'Brien, Kevin P. Johnson, Mark D. Groff, Harold L. Maves, Ryan C. Bavaro, Mary F. Crum-Cianflone, Nancy F. TI Prevalence and factors associated with asymptomatic gonococcal and chlamydial infection among US Navy and Marine Corps men infected with the HIV: a cohort study SO BMJ OPEN LA English DT Article ID SEXUALLY-TRANSMITTED-DISEASES; MALE ARMY RECRUITS; SAN-FRANCISCO; UNITED-STATES; PHARYNGEAL CHLAMYDIA; PRIMARY-CARE; GONORRHEA; SEX; EPIDEMIOLOGY; HEALTH AB Objectives: Neisseria gonorrhoeae (GC) and Chlamydia trachomatis (CT) can facilitate transmission of HIV. Men who have sex with men (MSM) may harbour infections at genital and extragenital sites. Data regarding extragenital GC and CT infections in military populations are lacking. We examined the prevalence and factors associated with asymptomatic GC and CT infection among this category of HIV-infected military personnel. Design: Cross-sectional cohort study (pilot). Setting: Infectious diseases clinic at a single military treatment facility in San Diego, CA. Participants: Ninety-nine HIV-positive men were evaluated-79% men who had sex with men, mean age 31 years, 36% black and 33% married. Inclusion criteria: male, HIV-infected, Department of Defense beneficiary. Exclusion criteria: any symptom related to the urethra, pharynx or rectum. Primary outcome measures: GC and CT screening results. Results: Twenty-four per cent were infected with either GC or CT. Rectal swabs were positive in 18% for CT and 3% for GC; pharynx swabs were positive in 8% for GC and 2% for CT. Only one infection was detected in the urine (GC). Anal sex (p=0.04), male partner (OR 7.02, p=0.04) and sex at least once weekly (OR 3.28, p=0.04) were associated with infection. Associated demographics included age <35 years (OR 6.27, p=0.02), non-Caucasian ethnicity (p=0.03), <3 years since HIV diagnosis (OR 2.75, p=0.04) and previous sexually transmitted infection (STI) (OR 5.10, p=0.001). Conclusions: We found a high prevalence of extragenital GC/CT infection among HIV-infected military men. Only one infection was detected in the urine, signalling the need for aggressive three-site screening of MSM. Clinicians should be aware of the high prevalence in order to enhance health through comprehensive STI screening practices. C1 [Carpenter, Robert J.; Adams, Nehkonti; O'Brien, Kevin P.; Johnson, Mark D.; Groff, Harold L.; Maves, Ryan C.; Bavaro, Mary F.; Crum-Cianflone, Nancy F.] Naval Med Ctr San Diego, Div Infect Dis, San Diego, CA 92134 USA. [Refugio, Oliver N.; Crum-Cianflone, Nancy F.] San Diego State Univ, Grad Sch Publ Hlth, San Diego, CA 92182 USA. [Crum-Cianflone, Nancy F.] Naval Hlth Res Ctr, San Diego, CA USA. RP Carpenter, RJ (reprint author), Naval Med Ctr San Diego, Div Infect Dis, San Diego, CA 92134 USA. EM rjc311@gmail.com OI Carpenter, Robert/0000-0002-6546-6122 NR 33 TC 6 Z9 6 U1 0 U2 0 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 2044-6055 J9 BMJ OPEN JI BMJ Open PY 2013 VL 3 IS 5 AR e002775 DI 10.1136/bmjopen-2013-002775 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 301NF UT WOS:000330538300077 ER PT B AU Pang, VO Han, PP Pang, JM AF Pang, Valerie Ooka Han, Peggy P. Pang, Jennifer M. BE Endo, R Rong, XL TI ASIAN AMERICAN AND PACIFIC ISLANDER STUDENTS Third Graders and the Achievement Gap SO EDUCATION ASIAN AMERICANS: ACHIEVEMENT, SCHOOLING, AND IDENTITIES SE Research on the Education of Asian and Pacific Americans LA English DT Article; Book Chapter ID MODEL MINORITY; PERFORMANCE; EDUCATION; BEHAVIOR; CHINESE; FAMILY AB This chapter extends research on the achievement gap found in Asian American and Pacific Islander (AAPI) seventh graders from California (Pang, Han, & Pang, 2011) by examining the reading and math performance of over 316,600 California AAPI third graders. As with the seventh grade population, we found achievement gap differences between the AAPI third graders and their White peers. Another similarity was significant differences across the 13 AAPI ethnic groups in reading and math performance. However, there was less variability in performance among the AAPI ethnic groups than for the seventh graders. Comparisons of the third grade and seventh grade results also suggest that some AAPI ethnic groups may be losing ground academically relative to Whites or other AAPI groups as they progress through school. These findings reveal that for AAPI students the achievement gap is an equity issue and needs to be addressed in the primary grades. C1 [Pang, Valerie Ooka] San Diego State Univ, Sch Teacher Educ, San Diego, CA 92182 USA. [Pang, Valerie Ooka] Brown Univ, Annenberg Inst, Providence, RI 02912 USA. [Han, Peggy P.] Naval Hlth Res Ctr, Dept Med Modeling & Informat Syst, San Diego, CA USA. [Pang, Jennifer M.] Northwest Assoc Biomed Res, Seattle, WA USA. [Pang, Jennifer M.] Seattle BioMed, Sci Outreach Educ Programs, BioQuest Acad, Seattle, WA USA. [Pang, Jennifer M.] Fred Hutchinson Canc Res Ctr, Seattle, WA USA. [Pang, Jennifer M.] Seattles Expanding Your Horizons, Seattle, WA USA. RP Pang, VO (reprint author), San Diego State Univ, Sch Teacher Educ, San Diego, CA 92182 USA. NR 44 TC 1 Z9 1 U1 1 U2 2 PU INFORMATION AGE PUBLISHING-IAP PI CHARLOTTE PA PO BOX 79049, CHARLOTTE, NC 28271-7047 USA BN 978-1-62396-213-5 J9 RES EDUC ASIAN PAC PY 2013 BP 29 EP 48 PG 20 WC Education & Educational Research; Ethnic Studies SC Education & Educational Research; Ethnic Studies GA BJL39 UT WOS:000328865800003 ER PT J AU Grisso, BL Park, G Salvino, LW Farrar, CR AF Grisso, B. L. Park, G. Salvino, L. W. Farrar, C. R. BE Chang, FK TI Structural Damage Identification in Stiffened Plate Fatigue Specimens Using Piezoelectric Active Sensing SO STRUCTURAL HEALTH MONITORING 2011: CONDITION-BASED MAINTENANCE AND INTELLIGENT STRUCTURES, VOL 2 SE Structural Health Monitoring LA English DT Proceedings Paper CT 8th International Workshop on Structural Health Monitoring CY SEP 13-15, 2011 CL Stanford Univ, Stanford, CA SP AF Off Sci Res, Army Res Off, Natl Sci Fdn, Off Naval Res HO Stanford Univ AB This paper presents a guided wave structural health monitoring (SHM) technique, based on the use of piezoelectric active-sensors, used to determine the structural integrity of stiffened aluminum plates. For damage detection, the transmitted power between piezoelectric transducers used for Lamb wave propagation is utilized to analyze the extent of damage in the structure. Damage initiation and propagation were successfully monitored with the guided wave technique. Overall, these methods yielded sufficient damage detection capability to warrant further investigation into field deployment. This paper summarizes considerations needed to design such SHM systems, experimental procedures and results, and recommendations that can be used as guidelines for future investigations. C1 [Grisso, B. L.; Salvino, L. W.] Naval Surface Warfare Ctr, Carderock Div, West Bethesda, MD 20817 USA. RP Grisso, BL (reprint author), Naval Surface Warfare Ctr, Carderock Div, West Bethesda, MD 20817 USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-053-2 J9 STRUCT HLTH MONIT PY 2013 BP 1683 EP 1690 PG 8 WC Engineering, Multidisciplinary SC Engineering GA BJH31 UT WOS:000328194500041 ER PT J AU Miller, TJ Kilic, O Mirotznik, MS AF Miller, Thomas J. Kilic, Ozlem Mirotznik, Mark S. TI Antenna Cross-Polarization Isolation and Calibration of Hybrid-Polarization Radars SO IEEE ANTENNAS AND WIRELESS PROPAGATION LETTERS LA English DT Article DE Antenna measurements; crosstalk; radar cross section; radar polarimetry ID POLARIMETRIC SAR DATA AB This letter presents an experiment using a fully polarimetric hybrid-polarization (CL-pol) radar that employs separate spiral antennas for transmit of the orthogonal circular polarizations and operates from 8 to 16 GHz. We propose a model for the antenna cross-polarization isolation (XPI) and calibration of this radar. The transmit XPI is characterized by leveraging the Doppler shift caused by a continually rotating dihedral target illuminated by a circularly polarized wave. Experimental results show the validity of the radar model and antenna measurement technique. C1 [Miller, Thomas J.] Naval Surface Warfare Ctr, Carderock Div, West Bethesda, MD 20817 USA. [Kilic, Ozlem] Catholic Univ Amer, Washington, DC 20064 USA. [Mirotznik, Mark S.] Univ Delaware, Newark, DE 19716 USA. RP Miller, TJ (reprint author), Naval Surface Warfare Ctr, Carderock Div, West Bethesda, MD 20817 USA. EM thomas.j.miller1@navy.mil; kilic@cua.edu; mirotzni@ece.udel.edu FU Office of Naval Research FX This work was supported in part by the Office of Naval Research. NR 14 TC 2 Z9 2 U1 1 U2 10 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1536-1225 EI 1548-5757 J9 IEEE ANTENN WIREL PR JI IEEE Antennas Wirel. Propag. Lett. PY 2013 VL 12 BP 1200 EP 1203 DI 10.1109/LAWP.2013.2282251 PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 234YO UT WOS:000325680600007 ER PT J AU Jurkiewicz, DJ Chalfant, J Chryssostomidis, C AF Jurkiewicz, David J. Chalfant, Julie Chryssostomidis, Chrys GP IEEE TI Modular IPS Machinery Arrangement in Early-Stage Naval Ship Design SO 2013 IEEE ELECTRIC SHIP TECHNOLOGIES SYMPOSIUM (ESTS) LA English DT Proceedings Paper CT IEEE 5th Biennial Electric Ship Technologies Symposium (ESTS) CY APR 22-24, 2013 CL Arlington, VA SP IEEE, RTDS Technologies, U S Off Naval Res (ONR), Sci & Technol, Dept Navy, ABB, IEEE Power & Energy Soc (PES), IEEE Power Elect Soc (PELS), IEEE Ind Applicat Soc (IAS) AB Electrical power demands for naval surface combatants are projected to rise with the development of increasingly complex and power intensive combat systems. This trend coincides with the need to achieve maximum fuel efficiency at both high and low hull speeds. A proposed solution to meet current and future energy needs of conventionally powered naval surface combatants is through the use of an Integrated Power System (IPS), which is seen as the next evolution in naval ship design. In an effort to enhance the relationship between new-concept designs and historically-based ship design processes, this paper focuses on a novel approach of incorporating IPS at the earliest stage of the design process as part of assessing system-level tradeoffs early within the ship design process. This paper describes a methodology for the systematic design and arrangement of an IPS machinery plant to meet a desired power generation level. In conjunction with the methodology development, a hierarchical process and design tool were produced to assist in rapid development and evaluation of various IPS arrangements. The result of this process, through several case studies, provides insight into equipment selection philosophy, the initial sizing of the ship's machinery box, and the initial definition of electrical zones. C1 [Jurkiewicz, David J.] Naval Surface Warfare Ctr, Carderock Div, West Bethesda, MD USA. RP Jurkiewicz, DJ (reprint author), Naval Surface Warfare Ctr, Carderock Div, West Bethesda, MD USA. EM chalfant@mit.edu NR 10 TC 2 Z9 2 U1 1 U2 3 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4673-5245-1 PY 2013 BP 121 EP 127 PG 7 WC Energy & Fuels; Engineering, Marine; Engineering, Electrical & Electronic SC Energy & Fuels; Engineering GA BGV15 UT WOS:000324258200019 ER PT J AU Dougherty, AL MacGregor, AJ Han, PP Viirre, E Heltemes, KJ Galarneau, MR AF Dougherty, Amber L. MacGregor, Andrew J. Han, Peggy P. Viirre, Erik Heltemes, Kevin J. Galarneau, Michael R. TI Blast-related ear injuries among U.S. military personnel SO JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT LA English DT Article DE auditory; blast; combat; deployment; ear injury; hearing loss; hearing protection; military; tinnitus; tympanic membrane rupture ID TYMPANIC-MEMBRANE PERFORATION; HEARING-LOSS; BRAIN-INJURY; TRAUMA; EXPOSURE; BOMB; IRAQ; OVERPRESSURE; PATHOLOGY; LONDON AB Blast-related ear injuries are a concern during deployment because they can compromise a servicemember's situational awareness and adversely affect operational readiness. The objectives of this study were to describe blast-related ear injuries during Operation Iraqi Freedom, identify the effect of hearing protection worn at the point of injury, and explore hearing loss and tinnitus outcomes within one year after injury. The Expeditionary Medical Encounter Database was used to identify military personnel who survived blast-related injury, and it was linked with outpatient medical databases to obtain diagnoses of hearing loss and tinnitus. The prevalence of ear injuries was 30.7% (1,223 of 3,981). The most common ear injury diagnoses were "inner or middle ear injury involving tinnitus" and tympanic membrane (TM) rupture. Hearing protection reduced the odds of ear injury involving tinnitus. Personnel with TM rupture had higher odds of hearing loss (odds ratio [OR] = 6.65, 95% confidence interval [CI] = 5.04-8.78) and tinnitus outcomes (OR = 4.34, 95% CI = 3.12-6.04) than those without TM rupture. Ear injuries and hearing impairment are frequent consequences of blast exposure during combat deployment. Hearing protection is warranted for all service-members at risk of blast exposure. C1 [Dougherty, Amber L.; MacGregor, Andrew J.; Han, Peggy P.; Heltemes, Kevin J.; Galarneau, Michael R.] Naval Hlth Res Ctr, Dept Med Modeling Simulat & Mission Support, San Diego, CA 92106 USA. [Viirre, Erik] Naval Hlth Res Ctr, Warfighter Performance Dept, San Diego, CA 92106 USA. RP Dougherty, AL (reprint author), Naval Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. EM amber.dougherty@med.navy.mil FU U.S. Navy Bureau of Medicine and Surgery [60808] FX This material was based on work supported by the U.S. Navy Bureau of Medicine and Surgery (work unit number 60808). NR 39 TC 8 Z9 8 U1 1 U2 8 PU JOURNAL REHAB RES & DEV PI BALTIMORE PA DEPT OF VETERANS AFFAIRS REHABIL RES & DEVELOP CTR 103 SOUTH GAY STREET, BALTIMORE, MD 21202-4051 USA SN 0748-7711 J9 J REHABIL RES DEV JI J. Rehabil. Res. Dev. PY 2013 VL 50 IS 6 BP 893 EP 904 DI 10.1682/JRRD.2012.02.0024 PG 12 WC Rehabilitation SC Rehabilitation GA 217HJ UT WOS:000324350200015 PM 24030196 ER PT S AU Mullen, L O'Connor, S Cochenour, B Dalgleish, F AF Mullen, Linda O'Connor, Shawn Cochenour, Brandon Dalgleish, Fraser BE Hou, WW Arnone, RA TI State-of-the-art tools for next-generation underwater optical imaging systems SO OCEAN SENSING AND MONITORING V SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Ocean Sensing and Monitoring V CY APR 30-MAY 01, 2013 CL Baltimore, MD SP SPIE DE underwater; laser; modulation; imaging ID LASER AB The detection and identification of underwater threats in coastal areas is of interest to the Navy. Conventional optical imaging systems are limited to scenarios where the number of attenuation lengths between the system and the object are less than 4. With a desire to operate at extended ranges and threats becoming smaller and better camouflaged, new approaches are needed. In response to these challenges, new transmitters and receivers are being developed to support the next-generation of underwater optical imaging systems. One of these systems is based on the modulated pulse concept where a pulsed laser source is encoded with a radar signal, and a range-gated, high-speed optical receiver recovers the radar modulation envelope. Subsequent processing of the radar signal provides a way to discriminate against multiply scattered light and to enhance image contrast and resolution. The challenge is developing transmitter and receiver hardware that meets the requirements of the modulated pulse technique. We report recent progress that has been made in developing modulated pulse transmitter and receiver hardware. A working prototype was demonstrated and tested in a controlled laboratory environment. The results of these initial experiments are presented. C1 [Mullen, Linda; O'Connor, Shawn; Cochenour, Brandon] Naval Air Syst Command, NAVAIR, Electroopt & Special Mission Sensors Div, Patuxent River, MD 20670 USA. RP Mullen, L (reprint author), Naval Air Syst Command, NAVAIR, Electroopt & Special Mission Sensors Div, 22347 Cedar Point Rd, Patuxent River, MD 20670 USA. NR 10 TC 0 Z9 0 U1 1 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-9515-0 J9 PROC SPIE PY 2013 VL 8724 AR UNSP 872402 DI 10.1117/12.2018489 PG 8 WC Remote Sensing; Optics SC Remote Sensing; Optics GA BGM74 UT WOS:000323517900002 ER PT S AU Namkung, J Kulowitch, P Schwartz, A AF Namkung, Juock Kulowitch, Paul Schwartz, Andy BE Kazemi, AA Kress, BC Thibault, S TI Optical fiber sensing of corroded materials using optical fibers as remote probes SO PHOTONIC APPLICATIONS FOR AEROSPACE, COMMERCIAL, AND HARSH ENVIRONMENTS IV SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Photonic Applications for Aerospace, Commercial, and Harsh Environments IV CY APR 29-MAY 01, 2013 CL Baltimore, MD SP SPIE DE Optical fiber; Optical fiber sensing; Corrosion sensing; Remote sensing; Evanescent wave; Health monitoring; Non destructive evaluation; Chemical sensing AB The purpose of this effort is to apply an in-situ corrosion remote sensing capability in aircraft structural environments. The technique will permit detection of corrosion on and within aircraft structures and component junctions that are susceptible to corrosion, but which are not accessible for visual inspection. The field application configuration includes surface and embedded optical fiber probes interfaced with a Fourier Transform Infrared (FTIR) interferometer for evanescent wave absorption spectroscopic measurements. The mature and fielded technique will allow periodic remote sensing for structural health monitoring and detection of corrosion. The potential advantages of optical fiber sensors result from the fact that the sensing element, the optical fiber, is small size, light weight, and immune to electromagnetic field. Also it can be attached to surfaces or embedded in junctions in aircraft structures, in locations where humidity and corrosion can accumulate, but cannot be directly observed. C1 [Namkung, Juock; Kulowitch, Paul; Schwartz, Andy] Naval Air Syst Command, Patuxent River, MD USA. RP Namkung, J (reprint author), Naval Air Syst Command, Patuxent River, MD USA. NR 7 TC 0 Z9 0 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-9511-2 J9 PROC SPIE PY 2013 VL 8720 AR UNSP 87201F DI 10.1117/12.2030599 PG 5 WC Engineering, Aerospace; Remote Sensing; Optics SC Engineering; Remote Sensing; Optics GA BGL78 UT WOS:000323434800046 ER PT S AU Harris, DC Cambrea, L AF Harris, Daniel C. Cambrea, Lee BE Tustison, RW Zelinski, BJ TI Assessment of Low-Expansion Tungstates for Thermal-Shock-Resistant Infrared Windows SO WINDOW AND DOME TECHNOLOGIES AND MATERIALS XIII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Window and Dome Technologies and Materials XIII CY MAY 01-02, 2013 CL Baltimore, MD SP SPIE ID CERAMICS; ZRW2O8; DIAMOND AB Low-thermal-expansion tungstate materials have the potential to be used as thermal-shock-resistant midwave (3-5 mu m) infrared windows. Material properties that favor thermal shock resistance are high strength, high thermal conductivity, low elastic modulus, and low thermal expansion. Sapphire, for example, owes its high thermal shock resistance to high strength and high thermal conductivity. In principle, it is possible to obtain even higher thermal shock resistance if a window material with near-zero thermal expansion can be made. This paper assesses recent work on Zr(WO4)(2) and Al0.5Sc1.5(WO4)(3). It is concluded that multi-phonon absorption in the midwave spectral region limits the optical capabilities of tungstate materials. These materials have more absorption-and therefore, more emission-than aluminum oxynitride in the 4-5 mu m wavelength region. C1 [Harris, Daniel C.; Cambrea, Lee] Naval Air Syst Command, China Lake, CA USA. RP Harris, DC (reprint author), Naval Air Syst Command, China Lake, CA USA. EM Daniel.Harris@navy.mil NR 23 TC 0 Z9 0 U1 1 U2 7 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-9499-3 J9 PROC SPIE PY 2013 VL 8708 AR UNSP 870809 DI 10.1117/12.2014815 PG 14 WC Materials Science, Multidisciplinary; Materials Science, Characterization & Testing; Optics SC Materials Science; Optics GA BGM25 UT WOS:000323491200005 ER PT J AU Rauh, MJ Aralis, HJ Melcer, T Macera, CA Sessoms, P Bartlett, J Galarneau, MR AF Rauh, Mitchell J. Aralis, Hilary J. Melcer, Ted Macera, Caroline A. Sessoms, Pinata Bartlett, Jamie Galarneau, Michael R. TI Effect of traumatic brain injury among US servicemembers with amputation SO JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT LA English DT Article DE amputation; blasts; combat-related; military; occupational therapy; odds ratio; physical therapy; postinjury complications; prosthetic use; rehabilitative use; service discharge; traumatic brain injury ID ARMY MEDICAL-CENTER; OPERATION IRAQI FREEDOM; ORTHOPEDIC TRAUMA; BATTLE CASUALTIES; AMPUTEE SOLDIERS; CARE; REHABILITATION; SEVERITY; PREVALENCE; DEPRESSION AB Servicemembers with combat-related limb loss often require substantial rehabilitative care. The prevalence of traumatic brain injury (TBI), which may impair cognitive and functional abilities, among servicemembers has increased. The primary objectives of this study were to determine the frequency of TBI among servicemembers with traumatic amputation and examine whether TBI status was associated with discharge to civilian status and medical and rehabilitative service use postamputation. U.S. servicemembers who had a combat-related amputation while deployed in Iraq or Afghanistan between 2001 and 2006 were followed for 2 yr postamputation. Data collected includes injury mechanism; postinjury complications; Injury Severity Score (ISS); and follow-up data, including military service discharge status and number of medical, physical, occupational therapy, and prosthetic-related visits. Of the 546 servicemembers with combat-related amputations, 127 (23.3%) had a TBI diagnosis. After adjusting for ISS and amputation location, those with TBI had a significantly greater mean number of medical and rehabilitative outpatient and inpatient visits combined (p < 0.01). Those with TBI were also at greater odds of developing certain postinjury complications. We recommend that providers treating servicemembers with limb loss should assess for TBI because those who sustained TBI required increased medical and rehabilitative care. C1 [Rauh, Mitchell J.; Aralis, Hilary J.; Macera, Caroline A.; Sessoms, Pinata; Bartlett, Jamie] USN, Hlth Res Ctr, Warfighter Performance Dept, San Diego, CA 92106 USA. [Rauh, Mitchell J.] San Diego State Univ, Doctor Phys Therapy Program, San Diego, CA 92182 USA. [Rauh, Mitchell J.; Melcer, Ted; Galarneau, Michael R.] USN, Hlth Res Ctr, Med Modeling Simulat & Mission Support Dept, San Diego, CA 92106 USA. [Macera, Caroline A.] San Diego State Univ, Grad Sch Publ Hlth, San Diego, CA 92182 USA. RP Rauh, MJ (reprint author), USN, Hlth Res Ctr, Warfighter Performance Dept, 140 Sylvester Rd, San Diego, CA 92106 USA. EM mrauh@mail.sdsu.edu RI Bartlett, Jamie/B-9756-2014 OI Bartlett, Jamie/0000-0001-7934-7119 FU Wounded, Ill, and Injured/Traumatic Brain Injury program of the U.S. Navy Bureau of Medicine and Surgery (DOD work unit) [60818] FX This material was based on work supported by the Wounded, Ill, and Injured/Traumatic Brain Injury program of the U.S. Navy Bureau of Medicine and Surgery (DOD work unit no. 60818). NR 46 TC 6 Z9 7 U1 1 U2 7 PU JOURNAL REHAB RES & DEV PI BALTIMORE PA DEPT OF VETERANS AFFAIRS REHABIL RES & DEVELOP CTR 103 SOUTH GAY STREET, BALTIMORE, MD 21202-4051 USA SN 0748-7711 J9 J REHABIL RES DEV JI J. Rehabil. Res. Dev. PY 2013 VL 50 IS 2 BP 161 EP 172 DI 10.1682/JRRD.2011.11.0212 PG 12 WC Rehabilitation SC Rehabilitation GA 149FF UT WOS:000319303700005 PM 23760997 ER PT S AU Faucett, DC Wright, J Ayre, M Choi, SR AF Faucett, D. Calvin Wright, Jennifer Ayre, Matthew Choi, Sung R. BE Singh, D Salem, J Halbig, M Mathur, S TI EFFECTS OF TARGET SUPPORTS ON FOREIGN OBJECT DAMAGE IN AN OXIDE/OXIDE CMC SO MECHANICAL PROPERTIES AND PERFORMANCE OF ENGINEERING CERAMICS AND COMPOSITES VII SE Ceramic Engineering and Science Proceedings LA English DT Proceedings Paper CT Mechanical Behavior and Performance of Ceramics and Composites Symposium CY JAN 22-27, 2012 CL Daytona Beach, FL SP Amer Ceram Soc (ACerS), Amer Ceram Soc (ACerS), Engn Ceram Div (ECD) ID CERAMIC-MATRIX COMPOSITE; STEEL BALL PROJECTILES; GRADE SILICON NITRIDES; IMPACT DAMAGE; STRENGTH DEGRADATION; SIC/SIC COMPOSITE; SURFACES; BEHAVIOR; AMBIENT; SPHERES AB Foreign object damage (FOD) aspects of an oxide/oxide ceramic matrix composite (CMC) were determined using spherical steel ball projectiles in impact velocity ranging from 100 to 340 m/s. The oxide/oxide CMC test targets were ballistically impacted at a normal incidence angle while sustained in cantilever support. Surface and subsurface impact damages were in the forms of craters, fiber breakage, delamination, cone cracks, and backside protrusion, typically observed in many CMCs in their ballistic impact responses. Qualitative impact damage was also assessed through post-impact residual strength measurements. Compared to two other types of target supports (full and partial supports), the cantilever support configuration resulted in the greatest impact damage of all the three. The impact damage in cantilever support is believed to have been involved both by quasi-static impression and by stress wave interactions, while the impact damage in partial and full supports was involved mainly by quasi-static dynamic impression. C1 [Faucett, D. Calvin; Wright, Jennifer; Ayre, Matthew; Choi, Sung R.] Naval Air Syst Command, Patuxent River, MD 20670 USA. RP Choi, SR (reprint author), Naval Air Syst Command, Patuxent River, MD 20670 USA. EM sung.choi1@inavy.mil NR 29 TC 0 Z9 0 U1 1 U2 1 PU AMER CERAMIC SOC PI WESTERVILLE PA 735 CERAMIC PLACE, WESTERVILLE, OH 43081-8720 USA SN 0196-6219 BN 978-1-118-21746-7; 978-1-118-20588-4 J9 CERAM ENG SCI PROC PY 2013 BP 299 EP 313 PG 15 WC Materials Science, Ceramics SC Materials Science GA BFH88 UT WOS:000319911600029 ER PT J AU Eskridge, SL Macera, CA Galarneau, MR Holbrook, TL Woodruff, SI MacGregor, AJ Morton, DJ Shaffer, RA AF Eskridge, Susan L. Macera, Caroline A. Galarneau, Michael R. Holbrook, Troy L. Woodruff, Susan I. MacGregor, Andrew J. Morton, Deborah J. Shaffer, Richard A. TI Combat blast injuries: Injury severity and posttraumatic stress disorder interaction on career outcomes in male servicemembers SO JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT LA English DT Article DE blast injury; career performance outcomes; combat blast; functional outcomes; injury severity; mental health; military discharge; Operation Iraqi Freedom; polytrauma; posttraumatic stress disorder ID TRAUMATIC BRAIN-INJURY; OPERATION IRAQI FREEDOM; MILITARY; REGISTRY; SYSTEM; SCORE AB The purpose of this study was to describe career performance outcomes after combat blast injury and to examine the relationship between the injury severity and type of military discharge. A retrospective cohort study of 4,255 male service-members injured in a combat blast as a part of Operation Iraqi Freedom was completed. In the total sample, 37.8% experienced a normal discharge and 8.3% had an early discharge. Of the 2,229 members who had a discharge code, 29.8% experienced a disability discharge. Both early attrition and disability discharge proportions were higher in those with posttraumatic stress disorder (PTSD) than in those without PTSD. There was a significant interaction between PTSD and injury severity in the discharge disability outcome. In those without PTSD, there was a dose-response relationship between injury severity and disability discharge. In those with PTSD, injury severity predicted disability discharge. The relationship between injury severity and disability discharge was less striking in service-members with PTSD than without PTSD. The effect of PTSD and injury severity on career performance outcomes after blast injuries should be factored into outcome planning. C1 [Eskridge, Susan L.; Galarneau, Michael R.; Woodruff, Susan I.; MacGregor, Andrew J.] USN, Hlth Res Ctr, Dept Med Modeling & Simulat, San Diego, CA 92106 USA. [Macera, Caroline A.; Shaffer, Richard A.] USN, Hlth Res Ctr, Dept Def HIV AIDS Prevent Program, San Diego, CA 92106 USA. [Macera, Caroline A.; Shaffer, Richard A.] San Diego State Univ, Grad Sch Publ Hlth, San Diego, CA 92182 USA. [Holbrook, Troy L.] San Diego State Univ, Sch Social Work, San Diego, CA 92182 USA. [Holbrook, Troy L.] EPI SOAR Consulting Inc, San Diego, CA USA. [Morton, Deborah J.] Univ Calif San Diego, Dept Family & Prevent Med, Div Epidemiol, San Diego, CA 92103 USA. RP Eskridge, SL (reprint author), USN, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. EM susan.eskridge@med.navy.mil FU U.S. Navy Bureau of Medicine and Surgery under the Wounded, Ill and Injured/Psychological Health/Traumatic Brain Injury Program [60808] FX This material was based on work supported by the U.S. Navy Bureau of Medicine and Surgery under the Wounded, Ill and Injured/Psychological Health/Traumatic Brain Injury Program (Work Unit No. 60808). NR 23 TC 1 Z9 1 U1 2 U2 5 PU JOURNAL REHAB RES & DEV PI BALTIMORE PA DEPT OF VETERANS AFFAIRS REHABIL RES & DEVELOP CTR 103 SOUTH GAY STREET, BALTIMORE, MD 21202-4051 USA SN 0748-7711 J9 J REHABIL RES DEV JI J. Rehabil. Res. Dev. PY 2013 VL 50 IS 1 BP 7 EP 15 DI 10.1682/JRRD.2012.01.0004 PG 9 WC Rehabilitation SC Rehabilitation GA 149FE UT WOS:000319303600010 PM 23516079 ER PT J AU Cash, JJ Davis, MC Ford, MD Groshens, TJ Guenthner, AJ Harvey, BG Lamison, KR Mabry, JM Meylemans, HA Reams, JT Sahagun, CM AF Cash, Jessica J. Davis, Matthew C. Ford, Michael D. Groshens, Thomas J. Guenthner, Andrew J. Harvey, Benjamin G. Lamison, Kevin R. Mabry, Joseph M. Meylemans, Heather A. Reams, Josiah T. Sahagun, Christopher M. TI High T-g thermosetting resins from resveratrol SO POLYMER CHEMISTRY LA English DT Article ID GLASS-TRANSITION TEMPERATURE; CYANATE ESTER RESIN; POLYCYANURATE NETWORKS; RENEWABLE RESOURCES; THERMAL-STABILITY; CURE KINETICS; POLYMERS; FLEXIBILITY; DEGRADATION; MECHANISMS AB The tricyanate esters of the natural product resveratrol (1) and dihydroresveratrol (2) were synthesized and subjected to thermal curing which gave polycyanurate network polymers which exhibited glass transition temperatures of >340 degrees C and 334 degrees C, respectively. Thermal decomposition temperatures of 412 degrees C and 403 degrees C for polycyanurates of 1 and 2, respectively, were typical of this class. However, char yields (600 degrees C) of 71% and 66% for 1 and 2, respectively, were more than double that from the polycyanurate of bisphenol A dicyanate (25%). C1 [Cash, Jessica J.; Davis, Matthew C.; Ford, Michael D.; Groshens, Thomas J.; Harvey, Benjamin G.; Meylemans, Heather A.] USN, Air Warfare Ctr, Chem & Mat Div, Michelson Lab, China Lake, CA 93555 USA. [Guenthner, Andrew J.; Lamison, Kevin R.; Mabry, Joseph M.; Reams, Josiah T.; Sahagun, Christopher M.] USAF, Res Lab, Aerosp Syst Directorate Edwards AFB, Edwards AFB, CA 93524 USA. RP Davis, MC (reprint author), USN, Air Warfare Ctr, Chem & Mat Div, Michelson Lab, China Lake, CA 93555 USA. EM matthew.davis@navy.mil; andrew.guenthner@edwards.af.mil FU Strategic Environmental Research and Development Program; Office of Naval Research; Air Force Office of Scientific Research, in part through the National Research Council's Research Associateship Program FX This research was supported by the Strategic Environmental Research and Development Program, the Office of Naval Research, and the Air Force Office of Scientific Research, in part through the National Research Council's Research Associateship Program (CMS). Thanks to Ann M. Moorehead, Mary E. Ray and Cynthia M. Kitchens of the NAWC Technical Library (China Lake) for collecting several of the references. NR 86 TC 22 Z9 22 U1 1 U2 21 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1759-9954 J9 POLYM CHEM-UK JI Polym. Chem. PY 2013 VL 4 IS 13 BP 3859 EP 3865 DI 10.1039/c3py00438d PG 7 WC Polymer Science SC Polymer Science GA 157HS UT WOS:000319887700026 ER PT J AU Haase, L Shukla, A Johnson, DC Thom, NJ Stanley, EA Simmons, AN Paulus, MP AF Haase, Lori Shukla, Akanksha Johnson, Douglas C. Thom, Nate J. Stanley, Elizabeth A. Simmons, Alan N. Paulus, Martin P. TI MINDFULNESS-BASED TRAINING ALTERS BRAIN ACTIVATION DURING AN EMOTION FACE PROCESSING TASK IN INFANTRY MARINES SO JOURNAL OF COGNITIVE NEUROSCIENCE LA English DT Meeting Abstract CT 20th Annual Meeting of the Cognitive-Neuroscience-Society CY APR 13-16, 2013 CL San Francisco, CA SP Cognit Neuroscience Soc C1 [Haase, Lori; Shukla, Akanksha; Johnson, Douglas C.; Simmons, Alan N.; Paulus, Martin P.] Univ Calif San Diego, San Diego, CA 92103 USA. [Johnson, Douglas C.; Thom, Nate J.] USN, Warfighter Performance Dept, Hlth Res Ctr, San Diego, CA 92152 USA. [Stanley, Elizabeth A.] Mind Fitness Training Inst, Alexandria, VA USA. [Simmons, Alan N.; Paulus, Martin P.] VA San Diego Healthcare Syst, San Diego, CA USA. RI Simmons, Alan/A-9815-2008 OI Simmons, Alan/0000-0003-3963-2112 NR 0 TC 0 Z9 0 U1 1 U2 3 PU MIT PRESS PI CAMBRIDGE PA 55 HAYWARD STREET, CAMBRIDGE, MA 02142 USA SN 0898-929X J9 J COGNITIVE NEUROSCI JI J. Cogn. Neurosci. PY 2013 SU S BP 128 EP 128 PG 1 WC Neurosciences; Psychology, Experimental SC Neurosciences & Neurology; Psychology GA 118MV UT WOS:000317030500498 ER PT J AU Erlandson, JM Thomas-Barnett, L Vellanoweth, RL Schwartz, SJ Muhs, DR AF Erlandson, Jon M. Thomas-Barnett, Lisa Vellanoweth, Rene L. Schwartz, Steven J. Muhs, Daniel R. TI From the Island of the Blue Dolphins: A Unique Nineteenth-Century Cache Feature From San Nicolas Island, California SO JOURNAL OF ISLAND & COASTAL ARCHAEOLOGY LA English DT Article DE Pacific Coast; North America; globalization; colonial history; culture change; technology ID CHANNEL-ISLANDS AB A cache feature salvaged from an eroding sea cliff on San Nicolas Island produced two redwood boxes containing more than 200 artifacts of Nicoleno, Native Alaskan, and Euro-American origin. Outside the boxes were four asphaltum-coated baskets, abalone shells, a sandstone dish, and a hafted stone knife. The boxes, made from split redwood planks, contained a variety of artifacts and numerous unmodified bones and teeth from marine mammals, fish, birds, and large land mammals. Nicoleno-style artifacts include 11 knives with redwood handles and stone blades, stone projectile points, steatite ornaments and effigies, a carved stone pipe, abraders and burnishing stones, bird bone whistles, bone and shell pendants, abalone shell dishes, and two unusual barbed shell fishhooks. Artifacts of Native Alaskan style include four bone toggling harpoons, two unilaterally barbed bone harpoon heads, bone harpoon fore-shafts, a ground slate blade, and an adze blade. Objects of Euro-American origin or materials include a brass button, metal harpoon blades, and ten flaked glass bifaces. The contents of the cache feature, dating to the early-to-mid nineteenth century, provide an extraordinary window on a time of European expansion and global economic development that created unique cultural interactions and social transformations. C1 [Erlandson, Jon M.] Univ Oregon, Museum Nat & Cultural Hist, Eugene, OR 97403 USA. [Erlandson, Jon M.] Univ Oregon, Dept Anthropol, Eugene, OR 97403 USA. [Thomas-Barnett, Lisa; Schwartz, Steven J.] USN, Air Warfare Ctr, Weap Div, Range Sustainabil Off, Point Mugu Nawc, CA USA. [Vellanoweth, Rene L.] Calif State Univ Los Angeles, Dept Anthropol, Los Angeles, CA 90032 USA. [Muhs, Daniel R.] US Geol Survey, Fed Ctr, Denver, CO 80225 USA. RP Erlandson, JM (reprint author), Univ Oregon, Dept Anthropol, 308 Condon Hall, Eugene, OR 97403 USA. EM jerland@uoregon.edu OI Erlandson, Jon/0000-0002-4705-4319 NR 32 TC 0 Z9 0 U1 2 U2 8 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1556-4894 J9 J ISL COAST ARCHAEOL JI J. Isl. Coast. Archaeol. PD JAN 1 PY 2013 VL 8 IS 1 BP 66 EP 78 DI 10.1080/15564894.2013.766913 PG 13 WC Archaeology SC Archaeology GA 117CJ UT WOS:000316929400005 ER PT J AU Crum-Cianflone, NF Moore, DJ Letendre, S Roediger, MP Eberly, L Weintrob, A Ganesan, A Johnson, E Del Rosario, R Agan, BK Hale, BR AF Crum-Cianflone, Nancy F. Moore, David J. Letendre, Scott Roediger, Mollie Poehlman Eberly, Lynn Weintrob, Amy Ganesan, Anuradha Johnson, Erica Del Rosario, Raechel Agan, Brian K. Hale, Braden R. TI Low prevalence of neurocognitive impairment in early diagnosed and managed HIV-infected persons SO NEUROLOGY LA English DT Article ID ACTIVE ANTIRETROVIRAL THERAPY; HUMAN-IMMUNODEFICIENCY-VIRUS; NEUROPSYCHOLOGICAL IMPAIRMENT; RISK-FACTORS; ERA; SEROCONVERSION; DISORDERS; ADHERENCE; DEMENTIA; PATTERNS AB Objective: To describe the prevalence of neurocognitive impairment (NCI) among early diagnosed and managed HIV-infected persons (HIV+) compared to HIV-negative controls. Methods: We performed a cross-sectional study among 200 HIV+ and 50 matched HIV-uninfected (HIV-) military beneficiaries. HIV+ patients were categorized as earlier (<6 years of HIV, no AIDS-defining conditions, and CD4 nadir >200 cells/mm(3)) or later stage patients (n = 100 in each group); both groups were diagnosed early and had access to care. NCI was diagnosed using a comprehensive battery of standardized neuropsychological tests. Results: HIV+ patients had a median age of 36 years, 91% were seroconverters (median window of 1.2 years), had a median duration of HIV of 5 years, had a CD4 nadir of 319, had current CD4 of 546 cells/mm(3), and 64% were on highly active antiretroviral therapy (initiated 1.3 years after diagnosis at a median CD4 of 333 cells/mm(3)). NCI was diagnosed among 38 (19%, 95% confidence interval 14%-25%) HIV+ patients, with a similar prevalence of NCI among earlier and later stage patients (18% vs 20%, p = 0.72). The prevalence of NCI among HIV+ patients was similar to HIV- patients. Conclusions: HIV+ patients diagnosed and managed early during the course of HIV infection had a low prevalence of NCI, comparable to matched HIV-uninfected persons. Early recognition and management of HIV infection may be important in limiting neurocognitive impairment. Neurology (R) 2013;80:371-379 C1 [Crum-Cianflone, Nancy F.; Roediger, Mollie Poehlman; Eberly, Lynn; Weintrob, Amy; Ganesan, Anuradha; Johnson, Erica; Del Rosario, Raechel; Agan, Brian K.; Hale, Braden R.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Crum-Cianflone, Nancy F.; Del Rosario, Raechel; Hale, Braden R.] USN, San Diego Med Ctr, HIV Clin, San Diego, CA 92152 USA. [Crum-Cianflone, Nancy F.; Hale, Braden R.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Moore, David J.; Letendre, Scott] Univ Calif San Diego, Hlth Neurobehav Res Program, San Diego, CA 92103 USA. [Roediger, Mollie Poehlman; Eberly, Lynn] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Weintrob, Amy] Walter Reed Army Med Ctr, Infect Dis Clin, Washington, DC 20307 USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Infect Dis Clin, Bethesda, MD USA. [Johnson, Erica] San Antonio Mil Med Ctr, Infect Dis Serv, San Antonio, TX USA. RP Crum-Cianflone, NF (reprint author), Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. EM nancy.crum@med.navy.mil OI Agan, Brian/0000-0002-5114-1669; Eberly, Lynn/0000-0003-4763-330X FU Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) program [IDCRP-016]; National Institute of Allergy and Infectious Diseases, NIH [Y1-AI-5072]; Neurobehavioral Health Research Center from the National Institute of Mental Health (UCSD HIV Neurobehavioral Research Center) [P30 MH62512] FX Support for this work (IDCRP-016) was provided by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, NIH, under Inter-Agency Agreement Y1-AI-5072. Support was also obtained by the Neurobehavioral Health Research Center from the National Institute of Mental Health (UCSD HIV Neurobehavioral Research Center, P30 MH62512). The content of this publication is the sole responsibility of the authors and does not necessarily reflect the views or policies of the NIH or the Department of Health and Human Services, the DoD, or the Departments of the Army, Navy, or Air Force. Mention of trade names, commercial products, or organizations does not imply endorsement by the US Government. Go to Neurology.org for full disclosures. NR 32 TC 23 Z9 24 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0028-3878 J9 NEUROLOGY JI Neurology PD JAN PY 2013 VL 80 IS 4 BP 371 EP 379 DI 10.1212/WNL.0b013e31827f0776 PG 9 WC Clinical Neurology SC Neurosciences & Neurology GA 076MQ UT WOS:000313961000015 PM 23303852 ER PT J AU MacGregor, AJ Dougherty, AL Tang, JJ Galarneau, MR AF MacGregor, Andrew J. Dougherty, Amber L. Tang, Janet J. Galarneau, Michael R. TI Postconcussive Symptom Reporting Among US Combat Veterans With Mild Traumatic Brain Injury From Operation Iraqi Freedom SO JOURNAL OF HEAD TRAUMA REHABILITATION LA English DT Article DE combat; concussion; depression; mild traumatic brain injury; military; posttraumatic stress disorder; PTSD ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; WAR VETERANS; AFGHANISTAN; DEPRESSION; DEPLOYMENT; OUTCOMES; RATES; CARE AB Objective: To examine the association between postconcussive symptoms and mild traumatic brain injury (MTBI) among combat veterans while adjusting for posttraumatic stress disorder (PTSD) and depression. Patients: Military personnel with provider-diagnosed MTBI (n = 334) or nonhead injury (n = 658) were identified from the Expeditionary Medical Encounter Database. Main Outcome Measures: Post-Deployment Health Assessments and Re-Assessments were used to examine postconcussive symptoms and self-rated health. Results: Personnel with MTBI were more likely to report headache (odds ratio [OR] = 3.37; 95% confidence interval [CI] = 2.19-5.17), back pain (OR = 1.79; 95% CI = 1.23-2.60), memory problems (OR = 1.86; 95% CI = 1.20-2.88), tinnitus (OR = 1.63; 95% CI = 1.10-2.41), and dizziness (OR = 2.13; 95% CI = 1.06-4.29) compared with those with non-head injuries. Among those with MTBI, self-reported decline in health was associated with memory problems (OR = 5.07; 95% CI = 2.56-10.02) and dizziness (OR = 10.60; 95% CI = 3.48-32.27). Conclusions: Mild traumatic brain injury is associated with reports of negative health consequences among combat veterans even when accounting for co-occurring psychological morbidity. The identification of postconcussive symptoms related to declines in a service member's self-rated health may be important in targeting and prioritizing clinical interventions. C1 [MacGregor, Andrew J.; Dougherty, Amber L.; Tang, Janet J.; Galarneau, Michael R.] USN, Hlth Res Ctr, Dept Med Modeling Simulat & Mission Support, San Diego, CA 92106 USA. RP Dougherty, AL (reprint author), USN, Hlth Res Ctr, Dept Med Modeling Simulat & Mission Support, 140 Sylvester Rd, San Diego, CA 92106 USA. EM amber.dougherty@med.navy.mil FU US Navy Bureau of Medicine under the Wounded, Ill and Injured/Psychological Health/Traumatic Brain Injury Program [60819] FX This work was supported by the US Navy Bureau of Medicine under the Wounded, Ill and Injured/Psychological Health/Traumatic Brain Injury Program, Work Unit No. 60819. NR 42 TC 18 Z9 18 U1 1 U2 18 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0885-9701 J9 J HEAD TRAUMA REHAB JI J. Head Trauma Rehabil. PD JAN-FEB PY 2013 VL 28 IS 1 BP 59 EP 67 DI 10.1097/HTR.0b013e3182596382 PG 9 WC Clinical Neurology; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA 070ZW UT WOS:000313555400007 PM 22688214 ER PT J AU Nguyen, S LeardMann, CA Smith, B Conlin, AMS Slymen, DJ Hooper, TI Ryan, MAK Smith, TC AF Nguyen, Stacie LeardMann, Cynthia A. Smith, Besa Conlin, Ava Marie S. Slymen, Donald J. Hooper, Tomoko I. Ryan, Margaret A. K. Smith, Tyler C. CA Millennium Cohort Study Team TI Is Military Deployment a Risk Factor for Maternal Depression? SO JOURNAL OF WOMENS HEALTH LA English DT Article ID MILLENNIUM COHORT; POSTPARTUM DEPRESSION; MENTAL-HEALTH; US MILITARY; FOLLOW-UP; PREVALENCE; VALIDATION; COMBAT; WOMEN; CARE AB Background: Maternal depression is a common condition among new mothers that can be associated with poor maternal health and negative consequences on infant health. Little research has been conducted to examine maternal depression, especially among military mothers, where unique conditions often exist. Using data from a large military cohort, this study prospectively examined the relationship between deployment experience before and after childbirth and maternal depression among U.S. servicewomen. Methods: The study included 1,660 female Millennium Cohort participants who gave birth during active duty service and completed baseline and follow-up questionnaires between 2001 and 2008. Maternal depression was assessed at follow-up using Primary Care Evaluation of Mental Disorders Patient Health Questionnaire criteria. Results: Deployment before childbirth, regardless of combat experience, and deployment without combat experience after childbirth did not increase the risk of maternal depression. Women who deployed and reported combat experience after childbirth were at increased risk for maternal depression compared with nondeployed women who gave birth (adjusted odds ratio [OR] 2.01, 95% confidence interval [CI] 1.17-3.43). Among the subgroup of female combat deployers, however, women who gave birth did not have a significantly increased risk for depression compared with those who did not give birth. Conclusions: Military women who deployed with combatlike experiences after childbirth were at increased risk for postdeployment maternal depression. The risk, however, appeared primarily related to combat rather than childbirth-related experiences. C1 [Nguyen, Stacie; LeardMann, Cynthia A.; Smith, Besa; Conlin, Ava Marie S.; Smith, Tyler C.] USN, Dept Deployment Hlth Res, Hlth Res Ctr, San Diego, CA 92106 USA. [Slymen, Donald J.] San Diego State Univ, Grad Sch Publ Hlth, San Diego, CA 92182 USA. [Hooper, Tomoko I.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Ryan, Margaret A. K.] USN, Hosp Camp Pendleton, Camp Pendleton, CA USA. RP LeardMann, CA (reprint author), USN, Dept Deployment Hlth Res, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. EM cynthia.leardmann@med.navy.mil FU U.S. Department of Defense [60002]; Military Operational Medicine Research Program of the U.S. Army Medical Research and Materiel Command, Fort Detrick, MD FX This study represents NHRC report 11-44, supported by the U.S. Department of Defense, under work unit No. 60002, and funded by the Military Operational Medicine Research Program of the U.S. Army Medical Research and Materiel Command, Fort Detrick, MD. The views expressed in this article are those of the authors and do not reflect the official policy or position of the U.S. Department of the Navy, U.S. Department of the Army, U.S. Department of the Air Force, U.S. Department of Defense, U.S. Department of Veterans Affairs, or the U.S. Government. Approved for public release; distribution is unlimited. The funding organizations had no role in the design and conduct of the study; collection, analysis, or preparation of data; or preparation, review, or approval of the manuscript. NR 40 TC 8 Z9 8 U1 1 U2 12 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-9996 J9 J WOMENS HEALTH JI J. Womens Health PD JAN PY 2013 VL 22 IS 1 BP 9 EP 18 DI 10.1089/jwh.2012.3606 PG 10 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Obstetrics & Gynecology; Women's Studies SC Public, Environmental & Occupational Health; General & Internal Medicine; Obstetrics & Gynecology; Women's Studies GA 071HE UT WOS:000313580800004 PM 23051068 ER PT J AU Macera, CA Aralis, HJ Rauh, MJ MacGregor, AJ AF Macera, Caroline A. Aralis, Hilary J. Rauh, Mitchell J. MacGregor, Andrew J. TI Do Sleep Problems Mediate the Relationship between Traumatic Brain Injury and Development of Mental Health Symptoms after Deployment? SO SLEEP LA English DT Article DE Posttraumatic stress disorder; sleep problems; traumatic brain injury ID POSTTRAUMATIC-STRESS-DISORDER; CONFIRMATORY FACTOR-ANALYSIS; IRAQ WAR; DISTURBANCE; INSOMNIA; COMBAT; DIMENSIONALITY; AFGHANISTAN; DEPRESSION; VETERANS AB Study Objectives: Military members screening positive for blast-related traumatic brain injury (TBI) may subsequently screen positive for posttraumatic stress disorder (PTSD) or depression. The role of sleep as a mediating factor in the development of mental health symptoms was explored. Design: Prospective study with symptoms evaluated at two time points. Setting: Postdeployment service in Iraq, Afghanistan, or Kuwait during 2008 and 2009. Participants: There were 29,640 US Navy and Marine Corps men (29,019 who did not screen positive for PTSD at baseline, 27,702 who did not screen positive for depression at baseline, and 27,320 who did not screen positive at baseline for either condition). Measurements and Results: After controlling for sleep problems, the adjusted odds of receiving a positive PTSD screening at follow-up decreased from 1.61 (95% confidence interval [CI] 1.21-2.14) to 1.32 (95% CI 0.99-1.77) for a subject screening positive for TBI relative to a subject screening negative, suggesting that sleep problems mediated 26% of TBI's effect on development of PTSD. Likewise, after controlling for sleep problems, the adjusted odds of receiving a positive depression screening decreased from 1.41 (95% CI 1.11-1.80) to 1.15 (95% CI 0.90-1.47), suggesting that sleep problems mediated 41% of TBI's effect on development of depression. Results were similar for those with either PTSD or depression (37% mediated). Conclusions: These results suggest that sleep problems mediate the effect of a positive TBI screening on the development of mental health disorders, and sleep problems may be an early indicator of risk for PTSD or depression. C1 [Macera, Caroline A.] USN, Dept Warfighter Performance, Hlth Res Ctr, DHAPP, San Diego, CA 92106 USA. RP Macera, CA (reprint author), USN, Dept Warfighter Performance, Hlth Res Ctr, DHAPP, 140 Sylvester Rd, San Diego, CA 92106 USA. EM carol.macera@med.navy.mil FU U.S. Navy Bureau of Medicine and Surgery [60818] FX This work was supported by the U.S. Navy Bureau of Medicine and Surgery under Work Unit No. 60818. The views expressed are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of Defense, or the US Government. Approved for public release; distribution is unlimited. This research was conducted in compliance with all applicable federal regulations governing the protection of human subjects (protocol NHRC. 2009.0020). NR 33 TC 26 Z9 26 U1 1 U2 11 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PD JAN 1 PY 2013 VL 36 IS 1 BP 83 EP 90 DI 10.5665/sleep.2306 PG 8 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 063LT UT WOS:000313001200013 PM 23288974 ER PT J AU Phillips, CJ Woolpert, T Sevick, C Faix, D Blair, PJ Crum-Cianflone, NF AF Phillips, Christopher J. Woolpert, Tabitha Sevick, Carter Faix, Dennis Blair, Patrick J. Crum-Cianflone, Nancy F. TI Comparison of the Effectiveness of Trivalent Inactivated Influenza Vaccine and Live, Attenuated Influenza Vaccine in Preventing Influenza-Like Illness Among US Military Service Members, 2006-2009 SO CLINICAL INFECTIOUS DISEASES LA English DT Article DE pneumonia; influenza-like illness; trivalent inactivated influenza vaccine; attenuated influenza vaccine; military ID UNITED-STATES; YOUNG-CHILDREN; A H1N1; SEASONAL INFLUENZA; RELATIVE EFFICACY; VIRUS VACCINE; IMPACT; ADULTS; WORLDWIDE; PERSONNEL AB Background. Influenza is a significant cause of morbidity, and vaccination is the preferred preventive strategy. Data regarding the preferred influenza vaccine type among adults are limited. Methods. The effectiveness of 2 currently available influenza vaccines LAIV and TIV in preventing influenza-like illness (ILI) was compared among US military members (aged 18-49 years) during 3 consecutive influenza seasons (2006-2009). ILI, influenza, and pneumonia events post-vaccination were compared between vaccine types using Cox proportional hazard models adjusted for sociodemographic factors, occupation, and geographic area. Results. A total of 41 670 vaccination events were evaluated, including 28 929 during 2 "well-matched" seasons (2006-2007 and 2008-2009: LAIV n = 22 734, TIV n = 6195) and 12 741 during a suboptimally matched season due to mild antigenic drift (2007-2008: LAIV n = 9447, TIV n = 3294). ILI crude incidence rates for LAIV and TIV were 139 and 127 cases per 1000 person-seasons for the well-matched seasons, respectively, and 150 and 165 cases per 1000 person-seasons for the suboptimally matched season, respectively. In the multivariable models, there were no differences in ILI events by vaccine type (well-matched seasons: hazard ratio [HR], 0.97; 95% confidence interval [CI], .90-1.06; suboptimally matched season: HR, 1.00; 95% CI, .90-1.11). There were also no differences in influenza and/or pneumonia events by vaccine group. Conclusions. Between 2006 and 2009, TIV and LAIV had similar effectiveness in preventing ILI and influenza/pneumonia events among healthy adults. C1 [Crum-Cianflone, Nancy F.] USN, Hlth Res Ctr, Dept Deployment Hlth Res, San Diego, CA 92152 USA. [Woolpert, Tabitha; Faix, Dennis; Blair, Patrick J.] USN, Hlth Res Ctr, Dept Operat Infect Dis, San Diego, CA 92152 USA. RP Crum-Cianflone, NF (reprint author), USN, Hlth Res Ctr, Dept Deployment Hlth Res, 160 Sylvester Rd, San Diego, CA 92152 USA. EM nancy.crum@med.navy.mil RI Valle, Ruben/A-7512-2013 FU US Military Vaccine (MILVAX) Agency FX This work was supported by the US Military Vaccine (MILVAX) Agency. The views expressed in this article are those of the authors and do not reflect the official policy or position of the US Department of the Navy, US Department of Defense, or the US government. Approved for public release, distribution is unlimited. This research has been conducted in compliance with all applicable federal regulations governing the protection of human subjects in research (protocol NHRC.2010.0027). NR 31 TC 9 Z9 9 U1 0 U2 21 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JAN 1 PY 2013 VL 56 IS 1 BP 11 EP 19 DI 10.1093/cid/cis860 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 058AE UT WOS:000312605500006 PM 23183869 ER PT J AU Wentworth, BA Stein, MB Redwine, LS Xue, Y Taub, PR Clopton, P Nayak, KR Maisel, AS AF Wentworth, Bailey A. Stein, Murray B. Redwine, Laura S. Xue, Yang Taub, Pam R. Clopton, Paul Nayak, Keshav R. Maisel, Alan S. TI Post-Traumatic Stress Disorder A Fast Track to Premature Cardiovascular Disease? SO CARDIOLOGY IN REVIEW LA English DT Review DE post-traumatic stress disorder; cardiovascular disease; biomarkers; MR-proADM; copeptin ID PITUITARY-ADRENAL AXIS; CORONARY-HEART-DISEASE; MALE MILITARY VETERANS; C-REACTIVE PROTEIN; SALIVARY CORTISOL; WAR VETERANS; MYOCARDIAL-INFARCTION; LIPID CONCENTRATIONS; PLATELET REACTIVITY; ANXIETY DISORDERS AB An increasing body of evidence reported in the literature indicates a possible role for post-traumatic stress disorder (PTSD) as a cause for cardiovascular disease (CVD). However, mechanistic evidence on the progression of adverse cardiac outcomes in PTSD is lacking. In this review, we examine the potential paths by which CVD could occur in those with PTSD. Dysregulation of the hypothalamic-pituitary-adrenal axis and autonomic nervous dysfunction are commonly observed in PTSD, which in turn leads to a variety of physiological changes potentially damaging to the heart. Increased inflammation, dysfunction of the vascular endothelium, hypercoagulability, and cardiac hyperreactivity all have been noted in patients with PTSD. Altered neurochemistry, most notably increased arginine vasopressin, as well as an increased prevalence of the metabolic syndrome, may also contribute to adverse cardiac outcomes. Although the association between PTSD and physical disease is often complicated by health risk behaviors or comorbid psychiatric conditions, the evidence for a link between PTSD and CVD is substantial. In our examination, we attempt to identify potential cardiac biomarkers that may be useful in detecting increased cardiac risk in patients with PTSD. As research in this area is exceedingly limited, we hope to inspire further research, as there is great potential value in identifying prognostically useful cardiac biomarkers so as to predict and prevent the onset of CVD in patients with PTSD. C1 [Wentworth, Bailey A.; Stein, Murray B.; Redwine, Laura S.; Xue, Yang; Taub, Pam R.; Maisel, Alan S.] Univ Calif San Diego, Dept Psychiat & Behav Med, La Jolla, CA 92093 USA. [Xue, Yang; Taub, Pam R.; Clopton, Paul; Maisel, Alan S.] VA San Diego Healthcare Syst, Dept Cardiol, San Diego, CA USA. [Nayak, Keshav R.] Balboa Naval Hosp, San Diego, CA USA. RP Wentworth, BA (reprint author), Univ Calif San Diego, Dept Psychiat & Behav Med, 9500 Gilman Dr,MC 0804, La Jolla, CA 92093 USA. EM bwentwor@ucsd.edu OI Taub, Pam/0000-0002-0684-0655; Redwine, Laura/0000-0001-7633-2034 FU Alere; Abbott; Nanosphere; BG Diagnostics; Gilead FX Dr. Alan Maisel consults and has research activities with a number of biomarker companies, although there is no specific conflict with this manuscript. Consultant at Alere. Grants from Alere, Abbott, Nanosphere, BG Diagnostics, Gilead. Member of Advisory Board at EFG Inc., Critical Diagnostics. NR 97 TC 39 Z9 39 U1 9 U2 35 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1061-5377 J9 CARDIOL REV JI Cardiol. Rev. PD JAN-FEB PY 2013 VL 21 IS 1 BP 16 EP 22 DI 10.1097/CRD.0b013e318265343b PG 7 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 049TI UT WOS:000312005900003 PM 22717656 ER PT B AU Walwanis, MM Swanson, BL Atkinson, BFW AF Walwanis, Melissa M. Swanson, Brandy L. Atkinson, Beth F. Wheeler BE Best, C Galanis, G Kerry, J Sottilare, R TI The Role of Instructor Operator Stations in Training SO FUNDAMENTAL ISSUES IN DEFENSE TRAINING AND SIMULATION SE Human Factors in Defence LA English DT Article; Book Chapter ID TECHNOLOGY C1 [Walwanis, Melissa M.; Atkinson, Beth F. Wheeler] Naval Air Warfare Ctr, Training Syst Div, Patuxent River, MD 20670 USA. [Swanson, Brandy L.] Kaegan Corp, Orlando, FL USA. RP Walwanis, MM (reprint author), Naval Air Warfare Ctr, Training Syst Div, Patuxent River, MD 20670 USA. NR 30 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-4722-1; 978-1-4094-4721-4 J9 HUM FACT DEFENCE PY 2013 BP 179 EP 191 PG 13 WC Social Sciences, Interdisciplinary SC Social Sciences - Other Topics GA BC4CY UT WOS:000352310800016 ER PT B AU Atkinson, BFW Abbott, RG Merket, DC AF Atkinson, Beth F. Wheeler Abbott, Robert G. Merket, Danielle C. BE Best, C Galanis, G Kerry, J Sottilare, R TI Measuring Up: Benefits and Trends in Performance Measurement Technologies SO FUNDAMENTAL ISSUES IN DEFENSE TRAINING AND SIMULATION SE Human Factors in Defence LA English DT Article; Book Chapter C1 [Atkinson, Beth F. Wheeler] Naval Air Warfare Ctr, Training Syst Div, Patuxent River, MD 20670 USA. [Abbott, Robert G.] Sandia Natl Labs, Livermore, CA 94550 USA. [Merket, Danielle C.] Naval Surface Warfare Ctr, Patuxent River, MD USA. RP Atkinson, BFW (reprint author), Naval Air Warfare Ctr, Training Syst Div, Patuxent River, MD 20670 USA. NR 42 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-4722-1; 978-1-4094-4721-4 J9 HUM FACT DEFENCE PY 2013 BP 285 EP 296 PG 12 WC Social Sciences, Interdisciplinary SC Social Sciences - Other Topics GA BC4CY UT WOS:000352310800025 ER PT B AU Li, X Soteriou, MC Kim, W Cohen, JM Herrmann, M Ham, F Kim, D Le, H Spyropoulos, JT AF Li, X. Soteriou, M. C. Kim, W. Cohen, J. M. Herrmann, M. Ham, F. Kim, D. Le, H. Spyropoulos, J. T. GP ASME TI HIGH FIDELITY SIMULATION OF THE SPRAY GENERATED BY A REALISTIC SWIRLING FLOW INJECTOR SO PROCEEDINGS OF THE ASME TURBO EXPO: TURBINE TECHNICAL CONFERENCE AND EXPOSITION, 2013, VOL 1B LA English DT Proceedings Paper CT ASME Turbo Expo: Turbine Technical Conference and Exposition CY JUN 03-07, 2013 CL San Antonio, TX SP Int Gas Turbine Inst ID LIQUID JETS; CROSS-FLOW; BREAKUP; ATOMIZATION; EQUATIONS AB Practical aero-engine fuel injection systems are highly complicated, combining complex fuel atomizer and air swirling elements to achieve good fuel-air mixing as well as long residence time in order to enhance both combustion efficiency and stability. While detailed understanding of the multiphase flow processes occurring in a realistic injector has been limited due to the complex geometries and the challenges in near-field measurements, high fidelity, first principles simulation offers, for the first time, the potential for a comprehensive physics-based understanding. In this work, such simulations have been performed to investigate the spray atomization and subsequent droplet transport in a swirling air stream generated by a complex multi-nozzle/swirler combination. A Coupled Level Set and Volume Of Fluid (CLSVOF) approach is used to directly capture the liquid-gas interface and an embedded boundary (EB) method is applied to flexibly handle the complex injector geometry. The ghost fluid (GF) method is also used to facilitate simulations at realistic fuel-air density ratio. Adaptive mesh refinement (AMR) and Lagrangian droplet models are used to efficiently resolve the multi-scale processes. To alleviate the global constraint on the time-step imposed by locally activated AMR near liquid jets, a separate AMR simulation focusing on jet atomization was performed for relatively short physical time and the resulting Lagrangian droplets are coupled into another simulation on a uniform grid at larger time-steps. The high cost simulations were performed at the U.S. Department of Defense high performance computing facilities using over 5000 processors. Experiments at the same flow conditions were conducted at UTRC. The simulation details of flow velocity and vorticity due to the interaction of the fuel jet and swirling air are presented. The velocity magnitude is compared with experimental measurement at two downstream planes. The two-phase spray spreading is compared with experimental images and the flow details are further analyzed to enhance understanding of the complex physics. C1 [Li, X.; Soteriou, M. C.; Kim, W.; Cohen, J. M.] United Technol Res Ctr, E Hartford, CT 06108 USA. [Herrmann, M.] Arizona State Univ, Tempe, AZ 85281 USA. [Ham, F.; Kim, D.; Le, H.] Cascade Technol Inc, Palo Alto, CA 94303 USA. [Spyropoulos, J. T.] Naval Air Syst Command, Patuxent River, MD 20670 USA. [Spyropoulos, J. T.] JSF Program Off, Patuxent River, MD 20670 USA. RP Li, X (reprint author), United Technol Res Ctr, 411 Silver Lane, E Hartford, CT 06108 USA. NR 29 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-5511-9 PY 2013 AR V002T04A070 PG 12 WC Engineering, Mechanical SC Engineering GA BD5DU UT WOS:000361341000070 ER PT B AU Nelson, C Cain, A Le Du, Y Morris, P Spyropoulos, J AF Nelson, Chris Cain, Alan Le Du, Yong Morris, Philip Spyropoulos, John GP ASME TI Toward Efficient Computational Aeroacoustic Analysis of High Speed Jets SO PROCEEDINGS OF THE ASME TURBO EXPO: TURBINE TECHNICAL CONFERENCE AND EXPOSITION, 2013, VOL 2 LA English DT Proceedings Paper CT ASME Turbo Expo: Turbine Technical Conference and Exposition CY JUN 03-07, 2013 CL San Antonio, TX SP Int Gas Turbine Inst AB Recent improvements in the algorithms and associated processes have resulted in significant improvements in the users' ability to obtain aeroacoustics analysis of hot supersonic jets in a timely manner using only moderate computational resources. This paper discusses these approaches using the example of the Compressible High Order Parallel Acoustics (CHOPA) solver. The fundamental strategy looks to balance computational expense with the accuracy required to predict the most important effects. The objective is to resolve the larger eddies accurately, but exchanges the resolution of fine turbulent structures in return for decreased computational resource requirements. These strategies continue to be developed, along with the corresponding software. As the work progresses, the team expects additional improvements in the near future. C1 [Nelson, Chris; Cain, Alan] Innovat Technol Applicat Co LLC, Chesterfield, MO 63006 USA. [Le Du, Yong; Morris, Philip] Penn State Univ, University Pk, PA 16802 USA. [Spyropoulos, John] Naval Air Syst Command, Patuxent River, MD USA. RP Nelson, C (reprint author), Innovat Technol Applicat Co LLC, Chesterfield, MO 63006 USA. NR 13 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-5513-3 PY 2013 AR V002T01A011 PG 14 WC Engineering, Aerospace; Energy & Fuels; Engineering, Mechanical SC Engineering; Energy & Fuels GA BD5DW UT WOS:000361341300011 ER PT B AU Morscher, GN Baker, C Gyekenyesi, A Faucett, C Choi, S AF Morscher, Gregory N. Baker, Christopher Gyekenyesi, Andrew Faucett, Calvin Choi, Sung GP ASME TI DAMAGE DETECTION AND TENSILE PERFORMANCE OF VARIOUS SIC/SIC COMPOSITES IMPACTED WITH HIGH SPEED PROJECTILE SO PROCEEDINGS OF THE ASME TURBO EXPO: TURBINE TECHNICAL CONFERENCE AND EXPOSITION, 2013, VOL 4 LA English DT Proceedings Paper CT ASME Turbo Expo: Turbine Technical Conference and Exposition CY JUN 03-07, 2013 CL San Antonio, TX SP Int Gas Turbine Inst ID MATRIX COMPOSITES AB Implementation of ceramic matrix composites (CMCs) in jet engine applications necessitates the understanding of high velocity impact behavior. To this end, various melt-infiltrated SiC/SiC composites were impacted at room temperature at 350 m/s with different support systems and tensile tested to failure. Non-Destructive techniques including electrical resistance (ER) and flash thermography were used to examine the specimen pre and post impact. Some specimens were then post-tested in order to assess retained properties. For post tested specimens acoustic emission was used to monitor damage accumulation during the post test and leading up to ultimate failure. Microscopy was performed to correlate damage with impact and post-impact applied stress. The properties of the impacted specimens were assessed based on relevant damage zones. The results are also compared with similar studies performed on similar composites with stress-concentrators such as holes or notches and post-impact specimens tested in bending. C1 [Morscher, Gregory N.; Baker, Christopher] Univ Akron, Akron, OH 44325 USA. [Gyekenyesi, Andrew] Ohio Aerosp Inst, Cleveland, OH USA. [Faucett, Calvin; Choi, Sung] NAVAIR, Patuxent River, MD USA. RP Morscher, GN (reprint author), Univ Akron, Akron, OH 44325 USA. NR 12 TC 0 Z9 0 U1 2 U2 3 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-5518-8 PY 2013 AR V004T02A010 PG 8 WC Education, Scientific Disciplines; Energy & Fuels; Engineering, Mechanical; Materials Science, Ceramics SC Education & Educational Research; Energy & Fuels; Engineering; Materials Science GA BD5JI UT WOS:000361499900010 ER PT B AU Wolfe, T Lee, YT Slipper, ME AF Wolfe, Tristan Lee, Yu-Tai Slipper, Michael E. GP ASME TI AN OFF-DESIGN PERFORMANCE PREDICTION MODEL FOR LOW-SPEED DOUBLE-DISCHARGE CENTRIFUGAL FANS SO PROCEEDINGS OF THE ASME TURBO EXPO: TURBINE TECHNICAL CONFERENCE AND EXPOSITION, 2013, VOL 4 LA English DT Proceedings Paper CT ASME Turbo Expo: Turbine Technical Conference and Exposition CY JUN 03-07, 2013 CL San Antonio, TX SP Int Gas Turbine Inst AB A generalized model for mapping the trend of the performance characteristics of a double-discharge centrifugal fan is developed based on the work by Casey and Robinson (C&R) which formulated compressor performance maps for tip-speed Mach numbers ranging from 0.4 to 2 using test data obtained from turbochargers with vaneless diffusers. The current paper focuses on low-speed applications for Mach number below 0.4. The C&R model uses four non-dimensional parameters at the design condition including the flow coefficient, the work input coefficient, the tip-speed Mach number and the polytropic efficiency, in developing a prediction model that requires limited geometrical knowledge of the centrifugal turbomachine. For the low-speed fan case, the C&R formulas are further modified to apply a low-speed, incompressible analysis. The effort described in this paper begins by comparing generalized results using efficiency data obtained from a series of fan measurements to that using the C&R model. For the efficiency map, the C&R model is found to heavily depend on the ratio of the flow coefficient at peak efficiency to that at the choke flow condition. Since choke flow is generally not applicable in the low-speed centrifugal fan operational environment, an alternate, but accurate estimation method based on fan free delivery derived from the fan test data is presented. Using this new estimation procedure, the modified C&R model predicts reasonably well using the double-discharge centrifugal fan data for high flow coefficients, but fails to correlate with the data for low flow coefficients. To address this undesirable characteristic, additional modifications to the C&R model are also presented for the fan application at low flow conditions. A Reynolds number correction is implemented in the work input prediction of the C&R model to account for low-speed test conditions. The new model provides reasonable prediction with the current fan data in both work input and pressure rise coefficients. Along with the developments for the efficiency and work input coefficient maps, the use of fan shut-off and free delivery conditions are also discussed for low-speed applications. C1 [Wolfe, Tristan; Slipper, Michael E.] Naval Surface Warfare Ctr, Carderock Div, Ships Syst Engn Stn, Philadelphia, PA 19112 USA. [Lee, Yu-Tai] Naval Surface Warfare Ctr, Carderock Div, Bethesda, MD USA. RP Wolfe, T (reprint author), Naval Surface Warfare Ctr, Carderock Div, Ships Syst Engn Stn, Philadelphia, PA 19112 USA. NR 14 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-5518-8 PY 2013 AR V004T10A008 PG 11 WC Education, Scientific Disciplines; Energy & Fuels; Engineering, Mechanical; Materials Science, Ceramics SC Education & Educational Research; Energy & Fuels; Engineering; Materials Science GA BD5JI UT WOS:000361499900077 ER PT B AU Wright, JM Faucett, DC Ayre, M Choi, SR AF Wright, Jennifer M. Faucett, D. Calvin Ayre, Matthew Choi, Sung R. GP ASME TI FOREIGN OBJECT DAMAGE (FOD) OF CERAMIC THERMAL BARRIER COATINGS (TBCs) IN GAS TURBINE AIRFOILS SO PROCEEDINGS OF THE ASME TURBO EXPO: TURBINE TECHNICAL CONFERENCE AND EXPOSITION, 2013, VOL 4 LA English DT Proceedings Paper CT ASME Turbo Expo: Turbine Technical Conference and Exposition CY JUN 03-07, 2013 CL San Antonio, TX SP Int Gas Turbine Inst DE Thermal barrier coatings (TBCs); foreign object damage (FOD); ballistic impact testing; coating delamination; delamination analysis ID IMPACT RESISTANCE; INELASTIC DEFORMATION; SIC/SIC COMPOSITES; EROSION; BEHAVIOR; MECHANISMS; PROJECTILES AB Ceramic thermal barrier coatings (TBCs),attributed to their inherent brittle nature, are highly susceptible to damage by impacting foreign particles when the impacting kinetic energy exceeds certain limits. The damage is termed foreign object damage (FOD) in related turbine components and results in various issues/problems to coatings as well as to substrates from delamination to spallation to cracking to catastrophic failure depending on the severity of impact. The FOD testing was performed using a ballistic impact gun for turbine airfoil components coated with 7% yittria stabilized zirconia (7YSZ) by electron beam physical vapor deposit (EB-PVD). A range of impact velocities up to Mach 1 was applied with three different projectile materials of steel, silicon nitride, and glass balls. The damage was assessed and characterized in terms of impact velocity, projectile material, and remaining life of turbine components. An energy-balance approach was made to develop a model to predict delamination of the TBCs upon impact. C1 [Wright, Jennifer M.; Faucett, D. Calvin; Ayre, Matthew; Choi, Sung R.] Naval Air Syst Command, Patuxent River, MD 20670 USA. RP Choi, SR (reprint author), Naval Air Syst Command, Patuxent River, MD 20670 USA. EM sung.choi1@navy.mil NR 29 TC 0 Z9 0 U1 1 U2 3 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-5518-8 PY 2013 AR V004T02A006 PG 10 WC Education, Scientific Disciplines; Energy & Fuels; Engineering, Mechanical; Materials Science, Ceramics SC Education & Educational Research; Energy & Fuels; Engineering; Materials Science GA BD5JI UT WOS:000361499900006 ER PT B AU Xue, YB Abdi, F Morscher, GN Choi, S AF Xue, Yibin Abdi, Frank Morscher, Gregory N. Choi, Sung GP ASME TI NON-DESTRUCTIVE CERAMIC MATRIX COMPOSITE IMPACT MODELING VALIDATION SO PROCEEDINGS OF THE ASME TURBO EXPO: TURBINE TECHNICAL CONFERENCE AND EXPOSITION, 2013, VOL 4 LA English DT Proceedings Paper CT ASME Turbo Expo: Turbine Technical Conference and Exposition CY JUN 03-07, 2013 CL San Antonio, TX SP Int Gas Turbine Inst DE Computation of Equivalent Electrical Properties; Ceramic Matrix Composite; Foreign object damage (POD) analysis; Ballistic impact simulation; SiC/SiC; Interphase ID DAMAGE; CRACKING; CREEP AB Ceramic matrix composite (CMC) materials technology is of fundamental importance to gas turbine engine application. POD (foreign Object Damage) in CMC components can result in component localized damage and a loss of post-impact performance. CMC impact generates a varying degree of damage from localized surface damage to complete penetration depending on the severity of impact events. Ceramic Composite equivalent electrical properties are computed based on simplified Multi-scale micromechanics equations. Electrical resistance and/or conductivity are computed utilizing the constituent material properties, effective medium, and percolation theories. Ceramic composite electrical properties simulation requires the algorithm development that combines the effective medium and percolation theories. A physically based percolation model is implemented to characterize the effective electrical conductivity of heterogeneous composites by means of the combination of effective medium (EM) and percolation equations with universal exponents. It is shown that the present model correlates well with the experimental electrical resistivity and acoustic emission data. The change in electrical resistivity after impact is compared with test data of a SA-SiC fiber reinforced SiC matrix composite. The predicted damage after impact and the trend of damage volume correlated well with experimental observations of damage shape and reduction in electrical resistance. Thus, an empirical relationship between damage volume and mechanisms and electrical resistance are developed and presented. C1 [Xue, Yibin; Abdi, Frank] AlphaSTAR Corp, Long Beach, CA 90804 USA. [Morscher, Gregory N.] Univ Akron, Akron, OH 44325 USA. [Choi, Sung] NAVAIR, Ratuxent River, MD USA. RP Xue, YB (reprint author), AlphaSTAR Corp, Long Beach, CA 90804 USA. NR 19 TC 0 Z9 0 U1 1 U2 5 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-5518-8 PY 2013 AR V004T02A004 PG 9 WC Education, Scientific Disciplines; Energy & Fuels; Engineering, Mechanical; Materials Science, Ceramics SC Education & Educational Research; Energy & Fuels; Engineering; Materials Science GA BD5JI UT WOS:000361499900004 ER PT J AU Guenthner, AJ Davis, MC Ford, MD Reams, JT Groshens, TJ Baldwin, LC Lubin, LM Mabry, JM AF Guenthner, Andrew J. Davis, Matthew C. Ford, Michael D. Reams, Josiah T. Groshens, Thomas J. Baldwin, Lawrence C. Lubin, Lisa M. Mabry, Joseph M. TI Polycyanurate Networks with Enhanced Segmental Flexibility and Outstanding Thermochemical Stability SO MACROMOLECULES LA English DT Article ID DICYANATE ESTER MONOMER; CYANATE ESTER; CURE KINETICS; PHYSICAL-PROPERTIES; TRICYANATE ESTER; THERMOSET CURE; RESINS; LIQUID; 1,3,5-TRIAROYLBENZENES; DEGRADATION AB The synthesis and physical properties of cyanurate networks formed from two new tricyanate monomers, 1,3,5-tris[(4-cyanatophenylmethyl]benzene and 3,5-bis[(4-cyanatophenylmethyl)]phenylcyanate, are reported and compared to those of 1,1,1-tris[(4-cyanatophenyl)]ethane (also known as ESR-255). All three networks possessed somewhat different aromatic contents and cross-link densities; however, the thermochemical stability of these networks, as determined by TGA, was outstanding, with that of 1,3,5-tris[(4-cyanatophenylmethyl)]benzene being among the best known for organic cyanate esters despite its comparatively high segmental flexibility. Moreover, the moisture uptake of cured 1,3,5-tris[(4-cyanatophenylmethyl)]benzene, at 2.2% after 96 h immersed in 85 degrees C water, was comparatively low for a cyanate ester network with a glass transition temperature of 320 degrees C at full cure. When cured for 24 h at 210 degrees C, the dry glass transition temperatures of the networks ranged from 245 to 285 degrees C, while the wet glass transition temperatures ranged from 225 to 240 degrees C. The similarity in glass transition temperatures resulted from a lower extent of cure in the networks with more rigid segments. In essence, for networks with very high glass transition temperatures at full cure, the process conditions, rather than the rigidity of the network, determined the attainable glass transition temperature. Because networks with a higher extent of cure tend to exhibit slower long-term degradation, in this case, the networks with greater segment flexibility enabled superior performance despite exhibiting a lower glass transition temperature at full cure. These results illustrate that, in contrast to the prevailing heuristics for improving the performance of high-temperature thermosetting polymer networks, a more flexible network with a lower glass transition temperature at full cure can offer an optimal combination of thermomechanical and thermochemical performance. C1 [Guenthner, Andrew J.; Mabry, Joseph M.] USAF, Res Lab, Prop Directorate, Edwards Afb, CA 93524 USA. [Davis, Matthew C.; Ford, Michael D.; Groshens, Thomas J.; Baldwin, Lawrence C.] USN, Air Warfare Ctr, Weap Div, China Lake, CA 93555 USA. [Reams, Josiah T.] USAF, Natl Res Council, Res Lab, Edwards Afb, CA 93524 USA. [Lubin, Lisa M.] ERC Inc, Edwards Afb, CA 93524 USA. RP Guenthner, AJ (reprint author), USAF, Res Lab, Prop Directorate, Edwards Afb, CA 93524 USA. EM andrew.guenthner@edwards.af.mil FU Office of Naval Research; Air Force Office of Scientific Research; Air Force Research Laboratory; National Research Council Research Associateship Program FX The support of the Office of Naval Research, the Air Force Office of Scientific Research, the Air Force Research Laboratory, and the National Research Council Research Associateship Program (J.T.R.) is gratefully acknowledged. The authors thank Dr. Suresh Sun of AFRL for helpful advice on the flash chromatography of monomer 1. NR 57 TC 10 Z9 10 U1 1 U2 22 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD DEC 25 PY 2012 VL 45 IS 24 BP 9707 EP 9718 DI 10.1021/ma302300g PG 12 WC Polymer Science SC Polymer Science GA 057LD UT WOS:000312563900017 ER PT J AU Schmidt, AL Paskoff, G Shender, BS Bass, CR AF Schmidt, Allison L. Paskoff, Glenn Shender, Barry S. Bass, Cameron R. TI Risk of Lumbar Spine Injury From Cyclic Compressive Loading SO SPINE LA English DT Article DE fatigue failure; lumbar; whole-body vibration; repeated loading; compression ID WHOLE-BODY VIBRATION; LOW-BACK-PAIN; INTRAABDOMINAL PRESSURE; FATIGUE BEHAVIOR; HEALTH-RISK; POSTURE; JOINTS; DISORDERS; MECHANISM; EXPOSURE AB Study Design. Survival analyses of a large cohort of published lumbar spine compression fatigue tests. Objective. To produce the first large-scale evaluation of human lumbar spine tolerance to repetitive compressive loading and to evaluate and improve guidelines for human exposure to whole-body vibration and repeated mechanical shock environments. Summary of Background Data. Several studies have examined the effects of compressive cyclic loading on the lumbar spine. However, no previous effort has coalesced these studies and produced an injury risk analysis with an expanded sample size. Guidelines have been developed for exposure limits to repetitive loading (e. g., ISO 2631-5), but there has been no large-scale verification of the standard against experimental data. Methods. Survival analyses were performed using the results of 77 male and 28 female cadaveric spinal segment fatigue tests from 6 previously published studies. Segments were fixed at each end and exposed to axial cyclic compression. The effects of the number of cycles, load amplitude, sex, and age were examined through the use of survival analyses. Results. Number of cycles, load amplitude, sex, and age all are significant factors in the likelihood of bony failure in the spinal column. Using a modification of the risk prediction parameter from ISO 2631-5, an injury risk model was developed, which relates risk of vertebral failure to repeated compressive loading. The model predicts lifetime risks less than 7% for industrial machinery exposure from axial compression alone. There was a 38% risk for a high-speed planing craft operator, consistent with epidemiological evidence. Conclusion. A spinal fatigue model which predicts the risk of in vitro lumbar spinal failure within a narrow confidence interval has been developed. Age and sex were found to have significant effects on fatigue strength, with sex differences extending beyond those accounted for by endplate area disparities. C1 [Schmidt, Allison L.; Bass, Cameron R.] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA. [Paskoff, Glenn; Shender, Barry S.] USN, Air Warfare Ctr, Div Aircraft, Patuxent River, MD USA. RP Schmidt, AL (reprint author), Duke Univ, Dept Biomed Engn, 136 Hudson Hall,Box 90281, Durham, NC 27708 USA. EM allison.schmidt@duke.edu FU Department of the Navy and Naval Air Warfare Center, Patuxent River, MD; Department of Biomedical Engineering, Duke University, Durham, NC FX The Department of the Navy and Naval Air Warfare Center, Patuxent River, MD, and Department of Biomedical Engineering, Duke University, Durham, NC, funds were received to support this work. NR 51 TC 0 Z9 0 U1 1 U2 15 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD DEC 15 PY 2012 VL 37 IS 26 BP E1614 EP E1621 DI 10.1097/BRS.0b013e3182752a19 PG 8 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 055DV UT WOS:000312396300003 PM 23023594 ER PT J AU Li, Y Srimathi, IR Woodward, RH Pung, AJ Poutous, MK Shori, RK Johnson, EG AF Li, Yuan Srimathi, Indumathi Raghu Woodward, Ryan H. Pung, Aaron J. Poutous, Menelaos K. Shori, Ramesh K. Johnson, Eric G. TI Guided-Mode Resonance Filters for Wavelength Selection in Mid-Infrared Fiber Lasers SO IEEE PHOTONICS TECHNOLOGY LETTERS LA English DT Article DE Fiber lasers; fiber optics; micro-optics; optical filters ID MU-M AB A narrowband mid-infrared (mid-IR) guided-mode resonance filter (GMRF) is designed and fabricated using a Hafnium Dioxide film/quartz wafer material system. The fabricated GMRF is then integrated into an erbium (Er)-doped Zr-Ba-La-Al-Na (ZBLAN) fluoride glass fiber laser as a wavelength selective feedback element. The laser operated at 2782 nm with a line-width less than 2 nm demonstrates the viability of GMRFs for wavelength selection in the mid-IR. C1 [Li, Yuan; Srimathi, Indumathi Raghu; Woodward, Ryan H.; Pung, Aaron J.; Poutous, Menelaos K.; Johnson, Eric G.] Clemson Univ, Microphoton Lab, Holcombe Dept Elect & Comp Engn, Clemson, SC 29634 USA. [Shori, Ramesh K.] USN, Air Warfare Ctr, China Lake, CA 93555 USA. RP Li, Y (reprint author), Clemson Univ, Microphoton Lab, Holcombe Dept Elect & Comp Engn, Clemson, SC 29634 USA. EM yli6@clemson.edu; iraghu@clemson.edu; rwoodwa@clemson.edu; apung@clemson.edu; mpoutou@clemson.edu; rshori@ee.ucla.edu; ejohns8@clemson.edu FU HEL-JTO/AFOSR MRI-"3D Meta-Optics for High Energy Lasers" [FA9550-10-1-0543] FX This work was supported by HEL-JTO/AFOSR MRI-"3D Meta-Optics for High Energy Lasers" FA9550-10-1-0543. NR 19 TC 3 Z9 3 U1 2 U2 21 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1041-1135 J9 IEEE PHOTONIC TECH L JI IEEE Photonics Technol. Lett. PD DEC 15 PY 2012 VL 24 IS 24 BP 2300 EP 2302 DI 10.1109/LPT.2012.2227305 PG 3 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA 049ZT UT WOS:000312022900006 ER PT J AU Stenger-Smith, JD Lai, WW Irvin, DJ Yandek, GR Irvin, JA AF Stenger-Smith, John D. Lai, William W. Irvin, David J. Yandek, Gregory R. Irvin, Jennifer A. TI Electroactive polymer-based electrochemical capacitors using poly(benzimidazo-benzophenanthroline) and its pyridine derivative poly(4-aza-benzimidazo-benzophenanthroline) as cathode materials with ionic liquid electrolyte SO JOURNAL OF POWER SOURCES LA English DT Article DE Electrochemical capacitor; Poly(4-aza-benzimidazo-benzophenanthroline); Ionic liquid; Energy density ID LADDER POLYMER; CONDUCTING POLYMERS; CONJUGATED POLYMERS; P-TYPE AB A novel processing technique was used to solution cast films of poly(benzimidazo benzophenanthroline), (BBL), and the novel ladder polymer poly(4-aza-benzimidazo benzophenanthroline) (Py-BBL), which were used as cathode materials in Type IV electroactive polymer-based electrochemical capacitors (EPECs). This new processing technique involves co-casting the polymer from solution with a room temperature ionic liquid, 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (EMIBTI). The new processing technique gave polymer films with superior transport properties and electrochemical stabilities, did not require a break-in period, and yielded higher charge capacity than the standard films. Co-cast films of BBL and Py-BBL were each incorporated into separate Type IV EPECs using poly(3,4-propylene dioxythiophene) (PProDOT) as the anode material. It was found that the PProDOT/BBL capacitors store, on average, about 50% more energy than a comparable PProDOT/Py-BBL EPEC. While PProDOT/BBL films have an energy density advantage at rates (power densities) less than 0.01 kW kg(-1), PProDOT/Py-BBL EPECs are capable of delivering higher energy than the BBL EPECs at rates greater than 0.01 kW kg(-1) (550 s per cycle). In fact, PProDOT/Py-BBL devices delivered more than ten times the energy density of PProDOT/BBL devices at 0.5 kW kg(-1) (50 s per cycle). The PProDOT/Py-BBL EPECs were cycled for 10,000 cycles at 65% depth of discharge and maintained 96% of the initial energy and power density, whereas the PProDOT/BBL EPECs were cycled under the same conditions and lost more than 35% of the initial energy and power density after only 2300 cycles. Published by Elsevier B.V. C1 [Stenger-Smith, John D.; Lai, William W.] USN, Air Warfare Ctr, Weap Div, Res & Intelligence Dept, China Lake, CA 93555 USA. [Stenger-Smith, John D.; Lai, William W.] NAWCWD, Div Chem, Res Dept, China Lake, CA 93555 USA. [Irvin, David J.] Syst & Mat Res Corp, Austin, TX 78756 USA. [Yandek, Gregory R.] USAF, Prop Mat Applicat Branch, Res Lab, Prop Directorate AFRL RZSM, Edwards AFB, CA 93524 USA. [Irvin, Jennifer A.] Texas State Univ, Dept Chem & Biochem, San Marcos, TX 78666 USA. RP Stenger-Smith, JD (reprint author), USN, Air Warfare Ctr, Weap Div, Res & Intelligence Dept, China Lake, CA 93555 USA. EM John.Stenger-Smith@navy.mil RI Irvin, Jennifer/C-7968-2013 OI Irvin, Jennifer/0000-0003-3500-8419 FU Office of Naval Research; China Lake ILIR Program FX The authors thank the Office of Naval Research (Drs. M. Anderson and P. Armistead) and the China Lake ILIR Program for the financial support of this project. The authors also thank the reviewers of our original manuscript for their suggestions and Paul Goodman for editing the revised manuscript. NR 18 TC 10 Z9 10 U1 3 U2 49 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD DEC 15 PY 2012 VL 220 BP 236 EP 242 DI 10.1016/j.jpowsour.2012.07.068 PG 7 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 022UW UT WOS:000309990300034 ER PT J AU Sun, L Feng, SM Yang, XD AF Sun, Lei Feng, Simin Yang, Xiaodong TI Loss enhanced transmission and collimation in anisotropic epsilon-near-zero metamaterials SO APPLIED PHYSICS LETTERS LA English DT Article ID NANOSCALE AB We verify the extraordinary transmission enhancement and collimation induced by the material loss in anisotropic epsilon-near-zero metamaterials, and reveal the physical mechanism of this exotic electromagnetic phenomenon via the iso-frequency contour analysis. In addition, we demonstrate the possibility in realization of such loss enhanced transmission of Gaussian beam in realistic silver-germanium multilayered structures by applying full-wave numerical simulations. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4770374] C1 [Sun, Lei; Yang, Xiaodong] Missouri Univ Sci & Technol, Dept Mech & Aerosp Engn, Rolla, MO 65409 USA. [Feng, Simin] USN, Div Phys, Air Warfare Ctr, China Lake, CA 93555 USA. RP Sun, L (reprint author), Missouri Univ Sci & Technol, Dept Mech & Aerosp Engn, Rolla, MO 65409 USA. EM yangxia@mst.edu RI Sun, Lei/A-7809-2017 OI Sun, Lei/0000-0002-5246-1373 FU Department of Mechanical and Aerospace Engineering; Materials Research Center at Missouri ST; Intelligent Systems Center at Missouri ST; Energy Research and Development Center at Missouri ST; University of Missouri Research Board; Ralph E. Powe Junior Faculty Enhancement Award; NAVAIR's ILIR program FX This work was partially supported by the Department of Mechanical and Aerospace Engineering, the Materials Research Center, the Intelligent Systems Center, and the Energy Research and Development Center at Missouri S&T, the University of Missouri Research Board, and the Ralph E. Powe Junior Faculty Enhancement Award. S. Feng was supported by NAVAIR's ILIR program. The authors acknowledge Y. He for his useful discussions about this work. NR 18 TC 29 Z9 31 U1 2 U2 31 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD DEC 10 PY 2012 VL 101 IS 24 AR 241101 DI 10.1063/1.4770374 PG 4 WC Physics, Applied SC Physics GA 056LD UT WOS:000312490000001 ER PT J AU Quinones, M Leung, R Williams, S AF Quinones, Martin Leung, Richard Williams, Sherry TI Algae Based Hydroprocessed Fuel Use on a Marine Gas Turbine SO JOURNAL OF ENGINEERING FOR GAS TURBINES AND POWER-TRANSACTIONS OF THE ASME LA English DT Article AB The Naval Surface Warfare Center, Carderock Division (NSWCCD) Philadelphia conducted a full scale gas turbine engine test using Rolls Royce engine models 501-K34 and 250-KS4 to assess engine performance and fuel combustion characteristics of an algae based hydroprocessed fuel. The fuel, hereafter described as alternate fuel, consisted of a 50/50 blend of NATO F-76 fuel and the algae based formulation. It is the first time that the U. S. Navy has used a nonpetroleum based fuel on a marine gas turbine. The test was conducted at the DDG 51 Land Based Engineering Site (LBES) of NSWCCD during Jan. 16-21, 2011. The alternate fuel test conducted on the 501-K34 engine consisted of seven cycles of engine operation, one using NATO F-76 fuel to develop a baseline run and six cycles using alternate fuel. Each cycle was 7 h and 20 min in duration and was composed of 27 distinct load scenarios. The total duration of the test was 44 h. The 250-KS4 engine was used as the starter mechanism for the 501-K34 engine. During the test, parameters for combustion temperature, fuel demand, fuel manifold pressure, engine start time, and operation under various load conditions were recorded. This paper discusses the results of the above test by comparing engine operation using alternate fuel to engine performance using NATO F-76 fuel. [DOI: 10.1115/1.4007339] C1 [Quinones, Martin] Naval Surface Warfare Ctr, Carderock Div, Philadelphia, PA 19112 USA. [Leung, Richard] Naval Sea Syst Command, Washington, DC 20376 USA. [Williams, Sherry] Naval Air Syst Command, Patuxent River, MD 20670 USA. RP Quinones, M (reprint author), Naval Surface Warfare Ctr, Carderock Div, Philadelphia, PA 19112 USA. EM martin.quinones@navy.mil; richard.leung@navy.mil; sherry.williams@navy.mil NR 3 TC 4 Z9 4 U1 0 U2 9 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0742-4795 J9 J ENG GAS TURB POWER JI J. Eng. Gas. Turbines Power-Trans. ASME PD DEC PY 2012 VL 134 IS 12 AR 122201 DI 10.1115/1.4007339 PG 5 WC Engineering, Mechanical SC Engineering GA 077NW UT WOS:000314035400008 ER PT J AU Carter, BJ Schenck, EC Wawrzynek, PA Ingraffea, AR Barlow, KW AF Carter, B. J. Schenck, E. C. Wawrzynek, P. A. Ingraffea, A. R. Barlow, K. W. TI Three-dimensional simulation of fretting crack nucleation and growth SO ENGINEERING FRACTURE MECHANICS LA English DT Article DE Fretting; Finite element analyses; Crack growth; Life prediction; Metals ID LIFE-PREDICTION METHODOLOGY; FINITE-ELEMENT-ANALYSIS; FRACTURE-MECHANICS; FATIGUE LIFE; PROPAGATION; TI-6AL-4V; CONTACT; PARAMETERS; MODEL; CONNECTIONS AB Fretting nucleation models and three-dimensional finite element analyses are used to compute the fretting fatigue life for metallic components. The models predict crack nucleation cycles and location(s). Discrete crack growth simulations provide stress intensity factor histories, with multiple, non-planar, three-dimensional cracks possible. The histories are input into crack growth rate model(s) to compute propagation cycles. The sum of fretting nucleation plus propagation cycles is the total life. Experimental fretting data, including crack nucleation location and cycles, and crack growth trajectory and propagation cycles, are used to validate the approach. Predictions for a realistic turbine blade/disk are comparable to field observations. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Carter, B. J.; Wawrzynek, P. A.] Fracture Anal Consultants Inc, Ithaca, NY 14850 USA. [Carter, B. J.; Wawrzynek, P. A.; Ingraffea, A. R.] Cornell Univ, Cornell Fracture Grp, Ithaca, NY 14851 USA. [Schenck, E. C.] Impact Technol LLC, Rochester, NY 14623 USA. [Barlow, K. W.] Naval Air Syst Command Prop & Power Engn, NAVAIR, Patuxent River, MD 20670 USA. RP Carter, BJ (reprint author), Fracture Anal Consultants Inc, 121 Eastern Hts Dr, Ithaca, NY 14850 USA. EM bjc21@cornell.edu FU US Navy SBIR [N68335-08-C-0011] FX The authors would like to thank Dr. Pat Golden at AFRL, Wright Patterson Air Force Base for supplying the data, drawings and finite element models for the dovetail fretting tests. The authors would also like to thank Dr. Jalees Ahmad for his assistance with the crack analog fretting model. This work was funded by a US Navy SBIR Contract (#N68335-08-C-0011). NR 47 TC 4 Z9 6 U1 1 U2 26 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0013-7944 J9 ENG FRACT MECH JI Eng. Fract. Mech. PD DEC PY 2012 VL 96 BP 447 EP 460 DI 10.1016/j.engfracmech.2012.08.015 PG 14 WC Mechanics SC Mechanics GA 068RQ UT WOS:000313384300032 ER PT J AU Jacobson, IG Horton, JL LeardMann, CA Ryan, MA Boyko, EJ Wells, TS Smith, B Smith, TC AF Jacobson, Isabel G. Horton, Jaime L. LeardMann, Cynthia A. Ryan, Margaret A. K. Boyko, Edward J. Wells, Timothy S. Smith, Besa Smith, Tyler C. TI Posttraumatic Stress Disorder and Depression Among U.S. Military Health Care Professionals Deployed in Support of Operations in Iraq and Afghanistan SO JOURNAL OF TRAUMATIC STRESS LA English DT Article ID MILLENNIUM COHORT; MENTAL-HEALTH; COMBAT DEPLOYMENT; PSYCHOMETRIC PROPERTIES; SERVICE MEMBERS; PTSD CHECKLIST; EXPOSURES; RISK; WAR; PREVALENCE AB Limited prospective studies exist that evaluate the mental health status of military health care professionals who have deployed. This study used prospective data from the Millennium Cohort Study with longitudinal analysis techniques to examine whether health care professionals deployed in support of the operations in Iraq and Afghanistan were more likely to screen positive for new-onset posttraumatic stress disorder (PTSD) or depression after deployment than individuals from other occupations. Of 65,108 subjects included, 9,371 (14.4%) reported working as health care professionals. The rates of new positive screens for PTSD or depression were similar for those in health care occupations (4.7% and 4.3%) compared with those in other occupations (4.6% and 3.9%) for the first and second follow-up, respectively. Among military personnel deployed with combat experience, health care professionals did not have increased odds for new-onset PTSD or depression over time. Among deployed health care professionals, combat experience significantly increased the odds: adjusted odds ratio = 2.01; 95% confidence interval [1.06, 3.83] for new-onset PTSD or depression. These results suggest that combat experience, not features specific to being a health care professional, was the key exposure explaining the development of these outcomes. C1 [Jacobson, Isabel G.; Horton, Jaime L.; LeardMann, Cynthia A.; Wells, Timothy S.; Smith, Besa; Smith, Tyler C.] USN, Deployment Hlth Res Dept, Hlth Res Ctr, San Diego, CA 92106 USA. [Ryan, Margaret A. K.] USN Hosp, Camp Pendleton, CA USA. [Boyko, Edward J.] Dept Vet Affairs Puget Sound Hlth Care Syst, Seattle Epidemiol Res & Informat Ctr, Seattle, WA USA. RP Jacobson, IG (reprint author), USN, Deployment Hlth Res Dept, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. EM isabel.jacobson@med.navy.mil NR 28 TC 6 Z9 6 U1 0 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0894-9867 J9 J TRAUMA STRESS JI J. Trauma Stress PD DEC PY 2012 VL 25 IS 6 BP 616 EP 623 DI 10.1002/jts.21753 PG 8 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA 051TW UT WOS:000312151400002 PM 23184886 ER PT J AU Gorham, ED Garland, CF Burgi, AA Mohr, SB Zeng, K Hofflich, H Kim, JJ Ricordi, C AF Gorham, E. D. Garland, C. F. Burgi, A. A. Mohr, S. B. Zeng, K. Hofflich, H. Kim, J. J. Ricordi, C. TI Lower prediagnostic serum 25-hydroxyvitamin D concentration is associated with higher risk of insulin-requiring diabetes: a nested case-control study SO DIABETOLOGIA LA English DT Article DE 25-Hydroxyvitamin D; Insulin-requiring diabetes; Military populations; Nested case-control study; Type 1 diabetes mellitus ID VITAMIN-D; CHILDHOOD; WORLDWIDE; MELLITUS AB Low serum 25-hydroxyvitamin D [25(OH)D] concentration may increase risk of insulin-requiring diabetes. A nested case-control study was performed using serum collected during 2002-2008 from military service members. One thousand subjects subsequently developed insulin-requiring diabetes. A healthy control was individually matched to each case on blood-draw date (+/- 2 days), age (+/- 3 months), length of service (+/- 30 days) and sex. The median elapsed time between serum collection and first diagnosis of diabetes was 1 year (range 1 month to 10 years). Statistical analysis used matched pairs and conditional logistic regression. ORs for insulin-requiring diabetes by quintile of serum 25(OH)D, from lowest to highest, were 3.5 (95% CI 2.0, 6.0), 2.5 (1.5, 4.2), 0.8 (0.4, 1.4), 1.1 (0.6, 2.8) and 1.0 (reference) (p (trend) < 0.001). The quintiles (based on fifths using serum 25(OH)D concentration in the controls) of serum 25(OH)D in nmol/l, were < 43 (median 28), 43-59 (median 52), 60-77 (median 70), 78-99 (median 88) and a parts per thousand yen100 (median 128). Individuals with lower serum 25(OH)D concentrations had higher risk of insulin-requiring diabetes than those with higher concentrations. A 3.5-fold lower risk was associated with a serum 25(OH)D concentration a parts per thousand yen60 nmol/l. C1 [Gorham, E. D.; Garland, C. F.; Burgi, A. A.; Mohr, S. B.; Zeng, K.; Kim, J. J.] USN, Hlth Res Ctr, San Diego, CA 92106 USA. [Gorham, E. D.; Garland, C. F.; Mohr, S. B.] Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA. [Hofflich, H.] Univ Calif San Diego, Dept Med, Div Internal Med, La Jolla, CA 92093 USA. [Ricordi, C.] Univ Miami, Miami Diabet Res Inst, Dept Surg, Miller Sch Med, Hollywood, FL USA. [Ricordi, C.] Univ Miami, Cell Transplant Ctr, Miller Sch Med, Hollywood, FL USA. RP Gorham, ED (reprint author), USN, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. EM Edward.Gorham@med.navy.mil OI Ricordi, Camillo/0000-0001-8092-7153 FU Congressional allocation to the University of Miami Diabetes Research Institute (Miami, FL, USA), through the Department of the Navy, Bureau of Medicine and Surgery [60126] FX This research was supported by a Congressional allocation to the University of Miami Diabetes Research Institute (Miami, FL, USA), through the Department of the Navy, Bureau of Medicine and Surgery, under Work Unit No. 60126. The views expressed in this report are those of the authors and do not represent an official position of the Department of the Navy, Department of Defense, or the US Government. NR 18 TC 22 Z9 23 U1 0 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0012-186X J9 DIABETOLOGIA JI Diabetologia PD DEC PY 2012 VL 55 IS 12 BP 3224 EP 3227 DI 10.1007/s00125-012-2709-8 PG 4 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 027VJ UT WOS:000310381800010 PM 22955995 ER PT J AU Heltemes, KJ Holbrook, TL MacGregor, AJ Galarneau, MR AF Heltemes, Kevin J. Holbrook, Troy L. MacGregor, Andrew J. Galarneau, Michael R. TI Blast-related mild traumatic brain injury is associated with a decline in self-rated health amongst US military personnel SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED LA English DT Article DE Mild traumatic brain injury; Self-rated health; Military; Combat casualty ID QUALITY-OF-LIFE; OPERATION-IRAQI-FREEDOM; WHITEHALL-II; AFGHANISTAN; DEPLOYMENT; MORTALITY; SYMPTOMS; VALIDITY AB Introduction: Mild traumatic brain injury (MTBI) has emerged as the preeminent injury of combat from the recent conflicts in Iraq and Afghanistan. Very little is known about short-and long-term outcomes after combat-related MTBI. As a measure of outcome after injury, self-rated health is a reliable, widely used measure that assesses perceived health. The primary aim of this study was to determine the effect of combat-related MTBI on self-reported health status after return from deployment. The secondary objective was to examine predictors of a decline in self-reported health status amongst US service members with MTBI, as compared to those service members with other minor non-TBI injuries. Patients and methods: MTBI cases and an injured comparison group were identified from the Expeditionary Medical Encounter Database records of 1129 male, US service members who experienced blast-related injuries in Iraq from March 2004 to March 2008. Self-rated health was assessed from the routinely administered pre- and post-deployment health assessment questionnaires by the following question, "Overall, how would you rate your health during the past month?" Possible responses were "poor", "fair", "good", "very good", or "excellent." A distinction was made between minor and major negative changes in health (i.e., very good to fair) based on these self-rated health outcomes captured post-injury. Results: For all personnel, post-injury levels of self-rated health were statistically significantly worse than pre-injury health rating. At 6 months post-injury, service members with MTBI were 5 times more likely to report a major negative change in health as compared to members with other mild injuries. This association was independent of age, rank, branch of service, Injury Severity Score, mental health diagnosis prior to injury, and having been referred to a health care professional. Discussion: Blast-related injuries, specifically MTBI, during deployment have negative consequences on service members' perception of health. Future research is needed to improve our understanding of the overall effects of MTBI on health and quality of life. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Heltemes, Kevin J.; Holbrook, Troy L.; MacGregor, Andrew J.; Galarneau, Michael R.] USN, Hlth Res Ctr, Dept Med Modeling Simulat & Mission Support, San Diego, CA 92106 USA. RP Heltemes, KJ (reprint author), USN, Hlth Res Ctr, Dept Med Modeling Simulat & Mission Support, 140 Sylvester Rd, San Diego, CA 92106 USA. EM kevin.heltemes@med.navy.mil FU US Army Medical Research and Materiel Command, Telemedicine and Advanced Technology Research Center FX The authors thank Dr. Mary Clouser for her assistance with data analysis and manuscript revision. The authors thank Science Applications International Corporation for its contributions to this work. Funding support for this research was provided through the US Army Medical Research and Materiel Command, Telemedicine and Advanced Technology Research Center. The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, or the US Government. Approved for public release; distribution is unlimited. This research has been conducted in compliance with all applicable federal regulations governing the protection of human subjects in research (Protocol NHRC.2003.0025). NR 26 TC 17 Z9 17 U1 0 U2 10 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0020-1383 J9 INJURY JI Injury-Int. J. Care Inj. PD DEC PY 2012 VL 43 IS 12 BP 1990 EP 1995 DI 10.1016/j.injury.2011.07.021 PG 6 WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery GA 028XM UT WOS:000310458600004 PM 21855064 ER PT J AU Wu, CT Valls, OT Halterman, K AF Wu, Chien-Te Valls, Oriol T. Halterman, Klaus TI Proximity effects in conical-ferromagnet/superconductor bilayers SO PHYSICAL REVIEW B LA English DT Article ID SUPERCONDUCTOR-FERROMAGNET STRUCTURES; TRIPLET SUPERCURRENTS; MAGNETIC-PROPERTIES; ERRH4B4; METALS AB We present a study of various aspects of proximity effects in F/S (ferromagnet/superconductor) bilayers, where F has a spiral magnetic texture such as that found in holmium, erbium, and other materials, and S is a conventional s-wave superconductor. We numerically solve the Bogoliubov-de Gennes (BdG) equations self-consistently and use the solutions to compute physical quantities relevant to the proximity effects in these bilayers. We obtain the relation between the superconducting transition temperature T-c and the thicknesses d(F) of the magnetic layer by solving the linearized BdG equations. We find that the T-c (d(F)) curves include multiple oscillations. Moreover, the system may be reentrant not only with d(F), as is the case when the magnet is uniform, but also with temperature T : the superconductivity disappears in certain ranges of d(F) or T. The T reentrance reported here occurs when d(F) is larger than the spatial period of the conical exchange field. We compute the condensation free energies and entropies from the full BdG equations and find the results are in agreement with T-c values obtained by linearization. The inhomogeneous nature of the magnet makes it possible for all odd triplet pairing components to be induced. We have investigated their properties and found that, as compared to the singlet amplitude, both the m = 0 and +/- 1 triplet components exhibit long-range penetration. For nanoscale bilayers, the proximity lengths for both layers are also obtained. These lengths oscillate with d(F) and they are found to be long range on both sides. These results are shown to be consistent with recent experiments. We also calculate the reverse proximity effect described by the three-dimensional local magnetization, and the local density of states, which reveals important energy-resolved signatures associated with the proximity effects. C1 [Wu, Chien-Te; Valls, Oriol T.] Univ Minnesota, Sch Phys & Astron, Minneapolis, MN 55455 USA. [Halterman, Klaus] USN, Air Warfare Ctr, Div Phys, Michelson Lab, China Lake, CA 93555 USA. [Valls, Oriol T.] Univ Minnesota, Minnesota Supercomp Inst, Minneapolis, MN 55455 USA. RP Wu, CT (reprint author), Univ Minnesota, Sch Phys & Astron, Minneapolis, MN 55455 USA. EM wu@physics.umn.edu; otvalls@umn.edu; klaus.halterman@navy.mil OI Halterman, Klaus/0000-0002-6355-3134 FU ONR; DoD (HPCMP); IARPA [N66001-12-1-2023] FX We thank C. Grasse for technical support. K. H. is supported in part by ONR and grants of computing resources from DoD (HPCMP). O.T.V. and C.-T. Wu are supported in part by IARPA under Grant No. N66001-12-1-2023. NR 56 TC 15 Z9 15 U1 1 U2 11 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9950 EI 2469-9969 J9 PHYS REV B JI Phys. Rev. B PD NOV 30 PY 2012 VL 86 IS 18 AR 184517 DI 10.1103/PhysRevB.86.184517 PG 15 WC Physics, Condensed Matter SC Physics GA 045RO UT WOS:000311714700005 ER PT J AU Crum-Cianflone, NF Moore, DJ Hale, B Agan, BK Letendre, S AF Crum-Cianflone, Nancy F. Moore, David J. Hale, Braden Agan, Brian K. Letendre, Scott TI The Evaluation and Diagnosis of "Insomnia" in Relation to Sleep Disturbance Prevalence and Impact in Early-Treated HIV-Infected Persons Reply SO CLINICAL INFECTIOUS DISEASES LA English DT Letter ID QUALITY INDEX C1 [Crum-Cianflone, Nancy F.] USN, San Diego Med Ctr, Div Infect Dis, HIV Clin, San Diego, CA 92134 USA. [Crum-Cianflone, Nancy F.; Hale, Braden; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Crum-Cianflone, Nancy F.; Hale, Braden] USN, Hlth Res Ctr, San Diego, CA 92134 USA. [Moore, David J.; Letendre, Scott] Univ Calif San Diego, HIV Neurobehav Res Program, San Diego, CA 92103 USA. RP Crum-Cianflone, NF (reprint author), USN, San Diego Med Ctr, Div Infect Dis, HIV Clin, 34800 Bob Wilson Dr,Ste 5, San Diego, CA 92134 USA. EM nancy.crum@med.navy.mil NR 7 TC 0 Z9 0 U1 1 U2 3 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD NOV 15 PY 2012 VL 55 IS 10 BP 1430 EP U216 DI 10.1093/cid/cis702 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 027SV UT WOS:000310374600028 ER PT J AU Moore, DJ Roediger, MJP Eberly, LE Blackstone, K Hale, B Weintrob, A Ganesan, A Agan, BK Letendre, SL Crum-Cianflone, NF AF Moore, David J. Roediger, Mollie J. P. Eberly, Lynn E. Blackstone, Kaitlin Hale, Braden Weintrob, Amy Ganesan, Anuradha Agan, Brian K. Letendre, Scott L. Crum-Cianflone, Nancy F. TI Identification of an Abbreviated Test Battery for Detection of HIV-Associated Neurocognitive Impairment in an Early-Managed HIV-Infected Cohort SO PLOS ONE LA English DT Article ID DEMOGRAPHICALLY CORRECTED NORMS; RAPID SCREENING-TEST; DEMENTIA-SCALE; NEUROPSYCHOLOGICAL IMPAIRMENT; ANTIRETROVIRAL THERAPY; COGNITIVE IMPAIRMENT; DISORDERS; DYSFUNCTION; VALIDATION; VALIDITY AB Background: HIV-associated neurocognitive disorders (HAND) remain prevalent despite improved antiretroviral treatment (ART), and it is essential to have a sensitive and specific HAND screening tool. Methods: Participants were 200 HIV-infected US military beneficiaries, managed early in the course of HIV infection, had few comorbidities, and had open access to ART. Participants completed a comprehensive, seven-domain (16-test), neuropsychological battery (similar to 120 min); neurocognitive impairment (NCI) was determined using a standardized score derived from demographically adjusted T-scores (global deficit score >= 0.5). Restricting the estimated administration time of the screening battery to < = 20 minutes, we examined the sensitivity and specificity of detecting NCI for all possible combinations of 2-, 3-, and 4- tests from the comprehensive battery. Results: Participants were relatively healthy (median CD4 count: 546 cells/mm(3)) with 64% receiving ART. Prevalence of NCI was low (19%). The best 2- test screener included the Stroop Color Test and the Hopkins Verbal Learning Test-Revised (11 min; sensitivity = 73%; specificity = 83%); the best 3- test screener included the above measures plus the Paced Auditory Serial Addition Test (PASAT; 16 min; sensitivity = 86%; specificity = 75%). The addition of Action Fluency to the above three tests improved specificity (18 min; sensitivity = 86%; specificity = 87%). Conclusions: Combinations of widely accepted neuropsychological tests with brief implementation time demonstrated good sensitivity and specificity compared to a time intensive neuropsychological test battery. Tests of verbal learning, attention/working memory, and processing speed are particularly useful in detecting NCI. Utilizing validated, easy to administer, traditional neuropsychological tests with established normative data may represent an excellent approach to screening for NCI in HIV. Citation: Moore DJ, Roediger MJP, Eberly LE, Blackstone K, Hale B, et al. (2012) Identification of an Abbreviated Test Battery for Detection of HIV-Associated Neurocognitive Impairment in an Early-Managed HIV-Infected Cohort. PLoS ONE 7(11): e47310. doi:10.1371/journal.pone.0047310 C1 [Moore, David J.; Blackstone, Kaitlin; Letendre, Scott L.] HIV Neurobehav Res Program, San Diego, CA 92103 USA. [Roediger, Mollie J. P.; Eberly, Lynn E.] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Roediger, Mollie J. P.; Eberly, Lynn E.; Hale, Braden; Weintrob, Amy; Ganesan, Anuradha; Agan, Brian K.; Crum-Cianflone, Nancy F.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Hale, Braden; Crum-Cianflone, Nancy F.] Naval Med Ctr San Diego, HIV Clin, San Diego, CA USA. [Hale, Braden; Crum-Cianflone, Nancy F.] Naval Hlth Res Ctr, San Diego, CA USA. [Weintrob, Amy] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. [Weintrob, Amy] Natl Naval Med Ctr, Infect Dis Clin, Bethesda, MD USA. RP Moore, DJ (reprint author), HIV Neurobehav Res Program, San Diego, CA 92103 USA. EM djmoore@ucsd.edu OI Agan, Brian/0000-0002-5114-1669 FU Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) program executed through the Uniformed Services University of the Health Sciences [IDCRP-016]; National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency [Y1-AI-5072]; National Institute of Mental Health (UCSD HIV Neurobehavioral Research Center) [P30 MH62512]; NIMH [MH 62512] FX Support for this work (IDCRP-016) was provided by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072. Support was also obtained from the National Institute of Mental Health (UCSD HIV Neurobehavioral Research Center, P30 MH62512). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.; The HIV Neurobehavioral Research Center (HNRC) is supported by Center award MH 62512 from NIMH. NR 34 TC 10 Z9 10 U1 1 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 8 PY 2012 VL 7 IS 11 AR e47310 DI 10.1371/journal.pone.0047310 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 053KE UT WOS:000312269500007 PM 23144815 ER PT J AU Karafiath, G AF Karafiath, Gabor TI Stern End Bulb for Energy Enhancement and Speed Improvement SO JOURNAL OF SHIP PRODUCTION AND DESIGN LA English DT Article DE resistance; powering; stern bulb; stern flap; wave-making AB Unlike the bow bulb, the stern end bulb (SEB) has been used on just a few ships to improve performance. In one of these rare, full-scale applications, a maximum resistance reduction in the 5% to 7% range is claimed. A few applications of SEBs are shown along with some model test data for a Naval Auxiliary ship. The rationale for SEB is discussed along with the hydrodynamic mechanism associated with a SEB. In addition to wave-making reduction, the SEB can reduce eddy-making and possibly improve course-keeping. The results of several fluid flow computations with initial SEB designs are shown for two ship classes: the T-AKE LEWIS and CLARK dry cargo ship and the DDG 51 ARLEIGH BURKE destroyer. The calculations use the Ship Wave Inviscid Flow Theory potential flow computer code and the FreeRans viscous flow free surface computer code. Several SEBs were designed and investigated analytically for the T-AKE class ships, and the best of these is predicted to reduce resistance by 4.5% at 20 knots. In addition, several initial SEB/Stern Flap configurations were designed for the DDG 51 Class Flight IIa destroyers and five configurations, some with just an SEB added to the hull and others with a combined SEB-Stern Flap configuration were model-tested. The examination of these initial efforts led to the design of several new-style combined SEB-Stern flap configurations, the best of which is predicted to save at least 745 Bbls of fuel per ship per year. C1 Naval Surface Warfare Ctr, Resistance & Prop Div, West Bethesda, MD 20817 USA. RP Karafiath, G (reprint author), Naval Surface Warfare Ctr, Resistance & Prop Div, West Bethesda, MD 20817 USA. FU Naval Surface Warfare Center Independent Applied Research Program FX The work was sponsored by the Naval Surface Warfare Center Independent Applied Research Program administered by Dr. John Barkyoumb. The hydrodynamic calculations were performed by Dr. Chen Wen Lin and Mr. Steven Fisher off code 5700. The model SEBs were manufactured using the Synthetic Lithography Apparatus (SLA), rapid prototyping machine, which uses computer-guided laser beams that solidify a liquid epoxy resin at specified locations. Mr. David Schwarzenberg and Mr Bryson Metcalf performed the SLA computer programming and were in charge of the model manufacturing. Mr. Dominic Cusanelli conducted the model tests and analysis. I am grateful for all these efforts. NR 12 TC 0 Z9 0 U1 2 U2 2 PU SOC NAVAL ARCHITECTS MARINE ENGINEERS PI JERSEY CITY PA 601 PAVONIA AVENUE, JERSEY CITY, NJ 07306 USA SN 2158-2866 EI 2158-2874 J9 J SHIP PROD DES JI J. Ship Prod. Des. PD NOV PY 2012 VL 28 IS 4 BP 172 EP 181 DI 10.5957/JSPD.28.4.120050 PG 10 WC Engineering, Marine SC Engineering GA V35PF UT WOS:000209160300004 ER PT J AU Cusanelli, DS AF Cusanelli, Dominic S. TI Hydrodynamic and Supportive Structure for Gated Ship Sterns: Amphibious Ship Stern Flap SO JOURNAL OF SHIP PRODUCTION AND DESIGN LA English DT Article DE stern flap; amphibious ship; stern gate support structure; ship performance trial; fuel consumption AB Stern flaps have now been at sea for more than two decades on a variety of U.S. Navy (USN) and U.S. Coast Guard classes, including destroyers, cruisers, frigates, cutters, and patrol craft. Application of flaps to large-deck amphibious-type ships is a fairly recent extension of the technology. Ship performance improvements such as delivered power reduction and fuel savings, and maximum speed increases, have been proven during at-sea trials and are well documented (Cusanelli 2002). USN amphibious ships contain well decks, which are accessed through large folding stern gates. When open, the gates are supported by sizable structures, which are partially submerged and affixed to the transom. A new concept, the hydrodynamic and supportive structure for gated ship sterns, i.e., the amphibious stern flap, was developed and patented by the author (Cusanelli 2004a). This design combines a stern flap's hydrodynamic performance surface with the stern gate support structure. The Naval Surface Warfare Center, Carderock Division, has now designed and implemented this new type of integrated stern flap and gate support structure on several USN amphibious ship classes. USN ship design and research and development (R&D) programs have resulted in amphibious stern flaps being implemented as new construction items on two new Navy amphibious ship classes and one new subclass. The Fleet Readiness R&D Program has funded amphibious stern flap design, retrofit installations, and evaluation trials on two existing amphibious ships. Each amphibious stern flap design spiral, model-test series, optimization, full-scale implementation as well as performance benefits and fuel savings are discussed. C1 Naval Surface Warfare Ctr, Carderock Div NSWCCD, West Bethesda, MD 20817 USA. RP Cusanelli, DS (reprint author), Naval Surface Warfare Ctr, Carderock Div NSWCCD, West Bethesda, MD 20817 USA. FU Naval Sea Systems Command (NAVSEA) Office SEA O3D4, RDTE; NAVSEA [PMS377]; Energy Plans and Policy Branch through the Shipboard Energy R&D Office (NSWCCD) [OPNAV N420, 859]; Fleet Readiness Research & Development Program (FRRDP) [971] FX The SAN ANTONIO (LPD 17) Class design program was sponsored by Naval Sea Systems Command (NAVSEA) Office SEA O3D4, RDT&E funding. The AMERICA (LHA 6) Class design program was sponsored by NAVSEA, Office PMS377. Model-scale stern flap design and testing program for MAKIN ISLAND (LHD 8), entitled "LHD(8) stern flap," was sponsored by the Energy Plans and Policy Branch (OPNAV N420) through the Shipboard Energy R&D Office (NSWCCD Code 859). The initial model-scale stern flap design and testing programs for the WASP (LHD 1) Class and for the WHIDBEY ISLAND (LSD 41) Class, entitled "Hydro-LSD/LHD Stern Flap," were sponsored by the Energy Plans and Policy Branch (OPNAV N420) through the Shipboard Energy R&D Office (NSWCCD Code 859). Funding for the full-scale installation, trials, and evaluation on both the KEARSARGE (LHD 3) and the WHIDBEY ISLAND (LSD 41) is through the Fleet Readiness Research & Development Program (FRR&DP) administered previously by R. Griggel (NSWCCD Code 916) and currently by A. Stankovich (Code 971). All amphibious stern flaps described here were designed by the author with the exception of that for the AMERICA (LHA 6), which was designed by K. Forgach (NSWCCD 5800). NR 9 TC 0 Z9 0 U1 1 U2 2 PU SOC NAVAL ARCHITECTS MARINE ENGINEERS PI JERSEY CITY PA 601 PAVONIA AVENUE, JERSEY CITY, NJ 07306 USA SN 2158-2866 EI 2158-2874 J9 J SHIP PROD DES JI J. Ship Prod. Des. PD NOV PY 2012 VL 28 IS 4 BP 182 EP 190 DI 10.5957/JSPD.28.4.120046 PG 9 WC Engineering, Marine SC Engineering GA V35PF UT WOS:000209160300005 ER PT J AU Feng, S Halterman, K AF Feng, Simin Halterman, Klaus TI Coherent perfect absorption in epsilon-near-zero metamaterials SO PHYSICAL REVIEW B LA English DT Article ID METALLIC GRATINGS; BAND; LIGHT; SURFACES; ABSORBERS; DESIGN AB In conventional materials, strong absorption usually requires that the material have either high loss or a large thickness-to-wavelength ratio (d/lambda >> 1). We find the situation to be vastly different for bilayer structures composed of ametallic substrate and an anisotropic epsilon-near-zero (ENZ) metamaterial, where the permittivity in the direction perpendicular to its surface, epsilon(z), vanishes. Remarkably, perfect absorption can occur in situations where the metamaterial is arbitrarily thin (d/lambda << 1) and arbitrarily low loss. Our numerical and analytical solutions reveal that under the conditions epsilon(z) -> 0 and J(epsilon(z)) >> R(epsilon(z)), at perfect absorption there is a linear relationship between the thickness and the loss, which means the thickness of the absorber can be pushed to zero by reducing the material loss to zero. This counterintuitive behavior is explained in terms of coherent perfect absorption (or stimulated absorption) via critical coupling to a fast wave propagating along the ENZ layer. C1 [Feng, Simin; Halterman, Klaus] USN, Air Warfare Ctr, Div Phys, Michelson Lab, China Lake, CA 93555 USA. RP Feng, SM (reprint author), USN, Air Warfare Ctr, Div Phys, Michelson Lab, China Lake, CA 93555 USA. EM simin.feng@navy.mil OI Halterman, Klaus/0000-0002-6355-3134 FU NAVAIR's Core S&T EO Initiative program; ILIR program FX S. Feng acknowledges the sponsorship of NAVAIR's Core S&T EO Initiative and ILIR programs. NR 42 TC 53 Z9 53 U1 11 U2 63 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD OCT 2 PY 2012 VL 86 IS 16 AR 165103 DI 10.1103/PhysRevB.86.165103 PG 6 WC Physics, Condensed Matter SC Physics GA 014OP UT WOS:000309385700003 ER PT J AU Pinder, RJ Greenberg, N Boyko, EJ Gackstetter, GD Hooper, TI Murphy, D Ryan, MAK Smith, B Smith, TC Wells, TS Wessely, S AF Pinder, Richard J. Greenberg, Neil Boyko, Edward J. Gackstetter, Gary D. Hooper, Tomoko I. Murphy, Dominic Ryan, Margaret A. K. Smith, Besa Smith, Tyler C. Wells, Timothy S. Wessely, Simon TI Profile of two cohorts: UK and US prospective studies of military health SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY LA English DT Editorial Material ID PERSIAN-GULF-WAR; MILLENNIUM COHORT; ANTHRAX VACCINATION; SMALLPOX VACCINATION; MEDICAL CONDITIONS; SERVICE MEMBERS; IRAQ WAR; POPULATION; PREVALENCE; VALIDATION C1 [Pinder, Richard J.; Greenberg, Neil; Murphy, Dominic; Wessely, Simon] Kings Coll London, Inst Psychiat, Weston Educ Ctr, Kings Ctr Mil Hlth Res, London WC2R 2LS, England. [Pinder, Richard J.; Greenberg, Neil; Murphy, Dominic; Wessely, Simon] Kings Coll London, Inst Psychiat, Weston Educ Ctr, Acad Ctr Def Mental Hlth, London WC2R 2LS, England. [Boyko, Edward J.] Dept Vet Affairs Puget Sound Hlth Care Syst, Seattle Epidemiol Res & Informat Ctr, Seattle, WA USA. [Gackstetter, Gary D.] Analyt Serv Inc ANSER, Arlington, VA USA. [Hooper, Tomoko I.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Ryan, Margaret A. K.] Naval Hosp Camp Pendleton, Camp Pendleton, CA USA. [Smith, Besa; Smith, Tyler C.; Wells, Timothy S.] Naval Hlth Res Ctr, Dept Deployment Hlth Res, San Diego, CA USA. RP Greenberg, N (reprint author), Kings Coll London, Inst Psychiat, Weston Educ Ctr, Kings Ctr Mil Hlth Res, Cutcombe Rd, London WC2R 2LS, England. EM sososanta@aol.com RI Wessely, Simon/A-8713-2008; OI Pinder, Richard/0000-0002-7010-6009 NR 47 TC 9 Z9 9 U1 0 U2 7 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0300-5771 J9 INT J EPIDEMIOL JI Int. J. Epidemiol. PD OCT PY 2012 VL 41 IS 5 BP 1272 EP 1282 DI 10.1093/ije/dyr096 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 021YU UT WOS:000309922700013 PM 21715528 ER PT J AU Eskridge, SL Macera, CA Galarneau, MR Holbrook, TL Woodruff, SI MacGregor, AJ Morton, DJ Shaffer, RA AF Eskridge, Susan L. Macera, Caroline A. Galarneau, Michael R. Holbrook, Troy L. Woodruff, Susan I. MacGregor, Andrew J. Morton, Deborah J. Shaffer, Richard A. TI Injuries from combat explosions in Iraq: Injury type, location, and severity SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED LA English DT Article DE Explosions; Blasts; Blast injury; Military ID TRAUMATIC BRAIN-INJURY; OPERATION ENDURING FREEDOM; BLAST INJURIES; REGISTRY; POLYTRAUMA; OUTCOMES; TERROR; CARE AB Introduction: Explosions have caused a greater percentage of injuries in Iraq and Afghanistan than in any other large-scale conflict. Improvements in body armour and field medical care have improved survival and changed the injury profile of service personnel. This study's objective was to determine the nature, body region, and severity of injuries caused by an explosion episode in male service personnel. Materials and methods: A descriptive analysis was conducted of 4623 combat explosion episodes in Iraq between March 2004 and December 2007. The Barell matrix was used to describe the nature and body regions of injuries due to a combat explosion. Results: A total of 17,637 International Classification of Diseases, Ninth Revision (ICD-9) codes were assigned to the 4623 explosion episodes, with an average of 3.8 ICD-9 codes per episode. The most frequent single injury type was a mild traumatic brain injury (TBI; 10.8%). Other frequent injuries were open wounds in the lower extremity (8.8%) and open wounds of the face (8.2%), which includes tympanic membrane rupture. The extremities were the body regions most often injured (41.3%), followed by head and neck (37.4%) and torso (8.8%). Conclusion: The results of this study support previous observations of TBI as a pre-eminent injury of the wars in Iraq and Afghanistan, with mild TBI as the most common single injury in this large cohort of explosion episodes. The extremities had the highest frequency of injuries for any one body region. The majority of the explosion episodes resulted in more than one injury, and the variety of injuries across nearly every body region and injury type suggests a complex nature of explosion injuries. Understanding the constellation of injuries commonly caused by explosions will assist in the mitigation, treatment, and rehabilitation of the effects of these injuries. (c) 2012 Elsevier Ltd. All rights reserved. C1 [Eskridge, Susan L.; Galarneau, Michael R.; Holbrook, Troy L.; MacGregor, Andrew J.] USN, Dept Med Modeling & Simulat, Hlth Res Ctr, San Diego, CA 92106 USA. [Macera, Caroline A.] USN, Dept Warfighter Performance, Hlth Res Ctr, San Diego, CA 92106 USA. [Macera, Caroline A.; Shaffer, Richard A.] San Diego State Univ, Grad Sch Publ Hlth, San Diego, CA 92182 USA. [Woodruff, Susan I.] San Diego State Univ, Sch Social Work, San Diego, CA 92182 USA. [Morton, Deborah J.] Univ Calif San Diego, Dept Family & Prevent Med, Div Epidemiol, San Diego, CA 92103 USA. [Shaffer, Richard A.] USN, Dept Def HIV AIDS Prevent Program, Hlth Res Ctr, San Diego, CA 92106 USA. RP Eskridge, SL (reprint author), USN, Dept Med Modeling & Simulat, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. EM susan.eskridge@med.navy.mil FU US Navy Bureau of Medicine and Surgery under the Wounded, Ill; Injured/Psychological Health/Traumatic Brain Injury Programme [60808] FX This work was supported by the US Navy Bureau of Medicine and Surgery under the Wounded, Ill, and Injured/Psychological Health/Traumatic Brain Injury Programme, Work Unit No. 60808. The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, or the U.S. Government. Approved for public release; distribution is unlimited. This research has been conducted in compliance with all applicable federal regulations governing the protection of human subjects in research (Protocol NHRC.2009.0023). NR 26 TC 37 Z9 38 U1 0 U2 17 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0020-1383 J9 INJURY JI Injury-Int. J. Care Inj. PD OCT PY 2012 VL 43 IS 10 BP 1678 EP 1682 DI 10.1016/j.injury.2012.05.027 PG 5 WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery GA 014OU UT WOS:000309386200010 PM 22769977 ER PT J AU Porter, CK Faix, DJ Shiau, D Espiritu, J Espinosa, BJ Riddle, MS AF Porter, Chad K. Faix, Dennis J. Shiau, Danny Espiritu, Jennifer Espinosa, Benjamin J. Riddle, Mark S. TI Postinfectious Gastrointestinal Disorders Following Norovirus Outbreaks SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID IRRITABLE-BOWEL-SYNDROME; GASTROESOPHAGEAL-REFLUX DISEASE; GASTROENTERITIS OUTBREAK; FUNCTIONAL DYSPEPSIA; UNITED-STATES; HEALTH; VIRUS AB Background. The US Centers for Disease Control and Prevention estimates 20.9 million norovirus infections annually in the United States. Although the acute disease burden is sizeable, emerging data suggest norovirus may be associated with chronic gastrointestinal problems. We identified known outbreaks in US military recruits and used the Defense Medical Encounter Database (DMED) to identify the risk of new onset functional gastrointestinal disorders (FGD) and gastroesophageal reflux disease (GERD). Methods. Subjects reporting for care of acute gastroenteritis (AGE) at a military treatment clinic during 3 known norovirus outbreaks were identified. Each AGE subject was matched with up to 4 subjects with unrelated medical encounters. Medical encounter data were analyzed for the duration of military service time (or a minimum of 1 year) to assess for incident FGD or GERD. Relative risks were calculated using regression models. Results. We identified 1718 subjects from 3 outbreaks. After controlling for important demographic covariates, the incidence of constipation, dyspepsia, and GERD was approximately 1.5-old higher (P < .01) in AGE-exposed subjects than matched subjects. We also noted variability in outcome incidence across outbreaks. Conclusions. It appears that the risk of dyspepsia, constipation, and GERD are higher among those who have AGE during a confirmed norovirus outbreak. Although these findings need confirmation, they suggest that dysmotility may result subsequent to these infections. If confirmed, the costs and morbidity associated with the chronic consequences of norovirus should be considered. C1 [Porter, Chad K.] USN, Enter Dis Dept, Infect Dis Directorate, Med Res Ctr, Silver Spring, MD 20910 USA. [Faix, Dennis J.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Shiau, Danny] USN, Bur Med & Surg, Falls Church, VA USA. [Espiritu, Jennifer; Espinosa, Benjamin J.] USN, Environm Prevent Med Unit 2, Norfolk, VA USA. RP Porter, CK (reprint author), USN, Enter Dis Dept, Infect Dis Directorate, Med Res Ctr, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM chad.porter@med.navy.mil FU Military Infectious Disease Research Program FX The views expressed in this article are those of the author and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, nor the US Government. This is a US Government work. There are no restrictions on its use. There were no financial conflicts of interests among any of the authors. The study protocol was approved by the Naval Medical Research Center Institutional Review Board in compliance with all applicable federal regulations governing the protection of human subjects. This study was conducted under support of the Military Infectious Disease Research Program. NR 31 TC 18 Z9 19 U1 0 U2 7 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD OCT 1 PY 2012 VL 55 IS 7 BP 915 EP 922 DI 10.1093/cid/cis576 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 002JI UT WOS:000308527500009 PM 22715178 ER PT J AU Davis, MC Guenthner, AJ Groshens, TJ Reams, JT Mabry, JM AF Davis, Matthew C. Guenthner, Andrew J. Groshens, Thomas J. Reams, Josiah T. Mabry, Joseph M. TI Polycyanurate networks from anethole dimers: Synthesis and characterization SO JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY LA English DT Article DE anethole; curing of polymers; cyanate ester; high performance; high temperature materials; molding; polyphenol; renewable resources; synthesis; thermal properties; thermosets ID RENEWABLE RESOURCES; ABSORPTION; CHEMISTRY; POLYMERS; ILLICIUM; DENSITY; ESTERS; RESINS AB Novel biorenewable bisphenols are obtained through simple and rapid chemical transformation of the natural product trans-anethole. The corresponding dicyanate esters are thermally cured to give polycyanurate networks. The thermal properties from differential scanning calorimetry, thermogravimetric, and dynamic thermomechanical analyses of the new dicyanate esters compare favorably with similar commercial products. (c) 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012 C1 [Davis, Matthew C.; Groshens, Thomas J.] USN, Chem & Mat Div, Michelson Lab, Air Warfare Ctr, China Lake, CA 93555 USA. [Reams, Josiah T.] USAF, Natl Res Council, Res Lab, Prop Directorate, Edwards AFB, CA 93524 USA. RP Davis, MC (reprint author), USN, Chem & Mat Div, Michelson Lab, Air Warfare Ctr, China Lake, CA 93555 USA. EM matthew.davis@navy.mil FU Office of Naval Research; Air Force Office of Scientific Research; Strategic Environmental Research and Development Program; National Research Council FX Financial support from the Office of Naval Research, the Air Force Office of Scientific Research, and the Strategic Environmental Research and Development Program are gratefully acknowledged. Support from the National Research Council's Research Associateship Program (J. T. R.) is also acknowledged. Thanks to Ann M. Moorehead and Cynthia M. Kitchens of the NAWC Technical Library (China Lake) for obtaining several of the references. NR 41 TC 18 Z9 18 U1 3 U2 16 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0887-624X J9 J POLYM SCI POL CHEM JI J. Polym. Sci. Pol. Chem. PD OCT 1 PY 2012 VL 50 IS 19 BP 4127 EP 4136 DI 10.1002/pola.26218 PG 10 WC Polymer Science SC Polymer Science GA 996MS UT WOS:000308093900024 ER PT J AU Momen, N Strychacz, CP Viirre, E AF Momen, Nausheen Strychacz, Chris P. Viirre, Erik TI Perceived Stigma and Barriers to Mental Health Care in Marines Attending the Combat Operational Stress Control Program SO MILITARY MEDICINE LA English DT Article AB The Department of Defense is aggressively addressing combat stress reactions (CSRs) through comprehensive Combat/Operational Stress Control (COSC) briefings/programs and referral resources for the prevention, identification, and treatment of stress reactions. The purpose of this study was to develop and administer a survey to assess perceptions of CSRs and barriers to care which affect help-seeking behavior in Marines attending the COSC program. A sample of 553 U.S. Marine Corps Officers and Enlisted personnel from Air (44%), Logistics (38%), and Infantry (18%) communities were recruited for the survey. The results suggested that misconceptions and stigma about CSRs still persist in Marines. The findings reinforced the need to facilitate treatment utilizatiori by focusing on mental health-related stigma as well as organizational barriers. C1 [Momen, Nausheen; Strychacz, Chris P.; Viirre, Erik] Naval Hlth Res Ctr, San Diego, CA 92106 USA. RP Momen, N (reprint author), Naval Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. NR 17 TC 4 Z9 4 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD OCT PY 2012 VL 177 IS 10 BP 1143 EP 1148 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA V33OE UT WOS:000209027300009 PM 23113439 ER PT J AU Goodman, DS Sivarajah, I Wells, JE Narducci, FA Smith, WW AF Goodman, D. S. Sivarajah, I. Wells, J. E. Narducci, F. A. Smith, W. W. TI Ion-neutral-atom sympathetic cooling in a hybrid linear rf Paul and magneto-optical trap SO PHYSICAL REVIEW A LA English DT Article ID LASER-COOLED IONS; ASSOCIATIVE IONIZATION; MASS-SPECTROMETER; SODIUM ATOMS; SIMULATION; COLLISIONS; INJECTION; XENON AB Long-range polarization forces between ions and neutral atoms result in large elastic scattering cross sections (e. g., similar to 10(6) a.u. for Na-Na+ or Na-Ca+ at cold and ultracold temperatures). This suggests that a hybrid ion-neutral trap should offer a general means for significant sympathetic cooling of atomic or molecular ions. We present SIMION 7.0 simulation results concerning the advantages and limitations of sympathetic cooling within a hybrid trap apparatus consisting of a linear rf Paul trap concentric with a Na magneto-optical trap (MOT). This paper explores the impact of various heating mechanisms on the hybrid system and how parameters related to the MOT, Paul trap, number of ions, and ion species affect the efficiency of the sympathetic cooling. C1 [Goodman, D. S.; Sivarajah, I.; Wells, J. E.; Smith, W. W.] Univ Connecticut, Dept Phys, Storrs, CT 06269 USA. [Narducci, F. A.] Naval Air Syst Command, EO Sensors Div, Patuxent River, MD 20670 USA. RP Goodman, DS (reprint author), Univ Connecticut, Dept Phys, Storrs, CT 06269 USA. FU National Science Foundation [PHY-0855570] FX We acknowledge support from the National Science Foundation under Grant No. PHY-0855570. F.A.N. thanks the University of Connecticut group for its hospitality during numerous visits. We also thank Jian Lin and Charles Talbot for their work on earlier versions of the SIMION simulations. NR 50 TC 13 Z9 13 U1 0 U2 13 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD SEP 10 PY 2012 VL 86 IS 3 AR 033408 DI 10.1103/PhysRevA.86.033408 PG 10 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA 002JH UT WOS:000308527400012 ER PT J AU Booth-Kewley, S Highfill-McRoy, RM Larson, GE Garland, CF Gaskin, TA AF Booth-Kewley, Stephanie Highfill-McRoy, Robyn M. Larson, Gerald E. Garland, Cedric F. Gaskin, Thomas A. TI Anxiety and Depression in Marines Sent to War in Iraq and Afghanistan SO JOURNAL OF NERVOUS AND MENTAL DISEASE LA English DT Article DE Anxiety; depression; psychiatric disorders; military populations; Marines; Iraq/Afghanistan wars; veterans; combat; deployment stressors ID POSTTRAUMATIC-STRESS-DISORDER; TRAUMATIC BRAIN-INJURY; MENTAL-HEALTH PROBLEMS; GULF-WAR; PEACEKEEPING OPERATIONS; PSYCHIATRIC DIAGNOSES; DEPLOYMENT STRESSORS; COMBAT DEPLOYMENT; VIETNAM VETERANS; ZONE STRESSORS AB Although the effects of combat deployment on posttraumatic stress disorder have been extensively studied, little is known about the effects of combat deployment on depression and anxiety. This study examined the factors associated with anxiety and depression in a sample of 1560 US Marines who were deployed to Iraq and Afghanistan. Eleven demographic and psychosocial factors were studied in relation to depression and anxiety. Five factors emerged as significant in relation to depression: deployment-related stressors, combat exposure, attitudes toward leadership, mild traumatic brain injury symptoms, and marital status. The same factors, with the exception of marital status, emerged as significant in relation to anxiety. Deployment-related stressors had a stronger association with both depression and anxiety than any other variable, including combat exposure. This finding is important because deployment-related stressors are potentially modifiable by the military. C1 [Booth-Kewley, Stephanie] Naval Hlth Res Ctr, Behav Sci & Epidemiol Dept, San Diego, CA 92106 USA. [Garland, Cedric F.] Univ Calif San Diego, Dept Family & Prevent Med, San Diego, CA 92103 USA. [Garland, Cedric F.] Univ Calif San Diego, Moores UCSD Canc Ctr, San Diego, CA 92103 USA. [Gaskin, Thomas A.] US Marine Corps, Combat Operat Stress Control, Quantico, VA USA. RP Booth-Kewley, S (reprint author), Naval Hlth Res Ctr, Behav Sci & Epidemiol Dept, 140 Sylvester Rd, San Diego, CA 92106 USA. EM stephanie.kewley@med.navy.mil FU Headquarters, Marine Corps (Combat Operational Stress Control), Work Unit [60518] FX This research was supported by Headquarters, Marine Corps (Combat Operational Stress Control), Work Unit 60518. The authors declare no conflict of interest. NR 55 TC 6 Z9 6 U1 2 U2 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-3018 J9 J NERV MENT DIS JI J. Nerv. Ment. Dis. PD SEP PY 2012 VL 200 IS 9 BP 749 EP 757 DI 10.1097/NMD.0b013e318266b7e7 PG 9 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 003KX UT WOS:000308611500004 PM 22922233 ER PT J AU Bukowinski, AT DeScisciolo, C Conlin, AMS Ryan, MAK Sevick, CJ Smith, TC AF Bukowinski, Anna T. DeScisciolo, Connie Conlin, Ava Marie S. Ryan, Margaret A. K. Sevick, Carter J. Smith, Tyler C. TI Birth defects in infants born in 1998-2004 to men and women serving in the U.S. military during the 1990-1991 Gulf War era SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Article DE Gulf War; birth defects; military; environmental exposures; reproductive health ID REPRODUCTIVE HEALTH; MATERNAL AGE; CONGENITAL-MALFORMATIONS; HOSPITALIZATION DATA; PREGNANCY OUTCOMES; SMALLPOX VACCINE; VETERANS; EXPOSURE; RISK; US AB BACKGROUND Concerns about reproductive health persist among U.S. military members who served in the 19901991 Gulf War. This study explores the long-term impact of 19901991 Gulf War deployment on the prevalence of birth defects among infants of Gulf War veterans. METHODS Health care data from the Department of Defense Birth and Infant Health Registry and demographic and deployment information from the Defense Manpower Data Center were used to identify infants born between 1998 and 2004 to both male and female 19901991 Gulf War veterans. Multivariable logistic regression models estimated the adjusted odds of any birth defect and eight specific birth defects among infants of deployers versus non-deployers. In addition, birth defects were evaluated among infants born to 19901991 Gulf War veterans with deployment-specific exposures. RESULTS Among 178,766 infants identified for these analyses, 3.4% were diagnosed with a birth defect in the first year of life. Compared to infants of non-deployers, infants of deployers were not at increased odds of being diagnosed with a birth defect, or any of eight specific birth defects, in the first year of life. A slightly increased prevalence of birth defects was observed among infants born to men who deployed to the 19901991 Gulf War for 153 to 200 days compared to those who deployed for 1 to 92 days. No other deployment-specific exposures were associated with birth defects in these infants. CONCLUSIONS The 19901991 Gulf War deployers, including those with specific exposures of concern, were not found to be at increased risk for having infants with birth defects 7 to 14 years after deployment. Birth Defects Research (Part A) 94:721728, 2012. Published 2012 Wiley Periodicals, Inc. C1 [Bukowinski, Anna T.; DeScisciolo, Connie; Conlin, Ava Marie S.; Sevick, Carter J.; Smith, Tyler C.] USN, Deployment Hlth Res Dept, Hlth Res Ctr, San Diego, CA 92106 USA. [Ryan, Margaret A. K.] USN, Clin Invest Program, Hosp Camp Pendleton, Camp Pendleton, CA USA. RP Bukowinski, AT (reprint author), USN, Deployment Hlth Res Dept, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. EM anna.bukowinski@med.navy.mil FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland FX We thank Scott L. Seggerman from the Management Information Division, Defense Manpower Data Center, Seaside, California. We also thank Jack M. Heller, PhD, from the Deployment Environmental Surveillance Program, U. S. Army Center for Health Promotion and Preventive Medicine. Additionally, we thank Gia Gumbs, MPH, and Kathy Snell from the Department of Defense Birth and Infant Health Registry; and Michelle LeWark, from the Naval Health Research Center, San Diego, California. We appreciate the support of the Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland. NR 52 TC 2 Z9 3 U1 0 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD SEP PY 2012 VL 94 IS 9 BP 721 EP 728 DI 10.1002/bdra.23062 PG 8 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA 001PY UT WOS:000308473800006 PM 22903974 ER PT J AU Broderick, MP Faix, DJ Hansen, CJ Blair, PJ AF Broderick, Michael P. Faix, Dennis J. Hansen, Christian J. Blair, Patrick J. TI Trends in Meningococcal Disease in the United States Military, 1971-2010 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID CONJUGATE VACCINE; RISK-FACTORS AB Meningococci have historically caused extensive illness among members of the United States military. Three successive meningococcal vaccine types were used from 1971 through 2010; overall disease incidence dropped by >90% during this period. During 2006-2010, disease incidence of 0.38 (cases per 100,000 person-years) among members of the US military was not significantly different from the incidence of 0.26 among the age-matched US general population. Of the 26 cases in the US military, 5 were fatal, 15 were vaccine failures (e.g., illness in a person who had been vaccinated), and 9 were caused by Neisseria meningitidis serogroup Y. Incidences among 17- to 19-year-old basic trainees and among US Marines were significantly higher than among comparison military populations (p<0.05). No apparent change in epidemiology of meningococcal disease was observed after replacement of quadrivalent polysaccharide vaccine with conjugate vaccine in 2007. The data demonstrate that vaccination with meningococcal vaccine is effective. C1 [Broderick, Michael P.; Faix, Dennis J.; Hansen, Christian J.; Blair, Patrick J.] USN, Hlth Res Ctr, San Diego, CA 92106 USA. RP Broderick, MP (reprint author), USN, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. EM michael.broderick@med.navy.mil RI Valle, Ruben/A-7512-2013 FU Global Emerging Infections System division of the Armed Forces Health Surveillance Center FX The Naval Health Research Center Meningococcal Disease Surveillance is supported by the Global Emerging Infections System division of the Armed Forces Health Surveillance Center. NR 18 TC 11 Z9 11 U1 0 U2 2 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD SEP PY 2012 VL 18 IS 9 BP 1430 EP 1437 DI 10.3201/eid1809.120257 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 995EC UT WOS:000307989700005 PM 22932005 ER PT J AU Kammerer, PE Montiel, S Kriner, P Bojorquez, I Ramirez, VB Vazquez-Erlbeck, M Azziz-Baumgartner, E Blair, PJ AF Kammerer, Peter E. Montiel, Sonia Kriner, Paula Bojorquez, Ietza Bejarano Ramirez, Veronica Vazquez-Erlbeck, Martha Azziz-Baumgartner, Eduardo Blair, Patrick J. TI Influenza-like illness surveillance on the California-Mexico border, 2004-2009 SO INFLUENZA AND OTHER RESPIRATORY VIRUSES LA English DT Article DE Bacterial infections; human; influenza; respiratory tract infections; sentinel surveillance ID RESPIRATORY SYNCYTIAL VIRUS; IONIZATION MASS-SPECTROMETRY; TRACT INFECTIONS; CLINICAL-SAMPLES; CHILDREN; DISEASE; US; IMPACT; IDENTIFICATION; ADENOVIRUSES AB Background Since 2004, the Naval Health Research Center, with San Diego and Imperial counties, has collaborated with the US Centers for Disease Control and Prevention to conduct respiratory disease surveillance in the US-Mexico border region. In 2007, the Secretariat of Health, Mexico and the Institute of Public Health of Baja California joined the collaboration. Objectives The identification of circulating respiratory pathogens in respiratory specimens from patients with influenza-like illness (ILI). Methods Demographic, symptom information and respiratory swabs were collected from enrollees who met the case definition for ILI. Specimens underwent PCR testing and culture in virology and bacteriology. Results From 2004 through 2009, 1855 persons were sampled. Overall, 36% of the participants had a pathogen identified. The most frequent pathogen was influenza (25%), with those aged 615 years the most frequently affected. In April 2009, a young female participant from Imperial County, California, was among the first documented cases of 2009 H1N1. Additional pathogens included influenza B, adenovirus, parainfluenza virus, respiratory syncytial virus, enterovirus, herpes simplex virus, Streptococcus pneumoniae, and Streptococcus pyogenes. Conclusions The US-Mexico border is one of the busiest in the world, with a large number of daily crossings. Due to its traffic, this area is an ideal location for surveillance sites. We identified a pathogen in 36% of the specimens tested, with influenza A the most common pathogen. A number of other viral and bacterial respiratory pathogens were identified. An understanding of the incidence of respiratory pathogens in border populations is useful for development of regional vaccination and disease prevention responses. C1 [Kammerer, Peter E.] USN, Dept Resp Dis Res, Hlth Res Ctr, San Diego, CA 92106 USA. [Montiel, Sonia; Azziz-Baumgartner, Eduardo] Ctr Dis Control & Prevent, Atlanta, GA USA. [Bojorquez, Ietza] Colegio Frontera Norte, Dept Populat Studies, Tijuana, Baja California, Mexico. RP Kammerer, PE (reprint author), USN, Dept Resp Dis Res, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. EM peter.kammerer@med.navy.mil RI Valle, Ruben/A-7512-2013 FU Department of Defense [60501]; Centers for Disease Control and Prevention; Armed Forces Health Surveillance Center Global Emerging Infections Surveillance and Response System; US Department of State Biosecurity Engagement Program FX We thank Melinda Balansay, Daisy Cabrera, Rob Coon, Christian Hansen, Karen Ferran, Akiko Kimura, Angelica Pon, and the staffs of participating county and jurisdictional health departments and clinics. This represents report 11-15, supported by the Department of Defense, under work unit no. 60501. This study was also funded by grants from the Centers for Disease Control and Prevention, the Armed Forces Health Surveillance Center Global Emerging Infections Surveillance and Response System, and the US Department of State Biosecurity Engagement Program. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of Defense, the US Government, or the CDC. Approved for public release; distribution is unlimited. This research has been conducted in compliance with all applicable federal regulations governing protection of human subjects in research. NR 29 TC 4 Z9 4 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1750-2640 J9 INFLUENZA OTHER RESP JI Influenza Other Respir. Viruses PD SEP PY 2012 VL 6 IS 5 BP 358 EP 366 DI 10.1111/j.1750-2659.2011.00316.x PG 9 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA 989KR UT WOS:000307559200008 PM 22212638 ER PT J AU Hurtado, SL Crain, JA Simon-Arndt, CM Highfill-McRoy, RM AF Hurtado, Suzanne L. Crain, Jenny A. Simon-Arndt, Cynthia M. Highfill-McRoy, Robyn M. TI Substance Abuse Counselor and Client Reports of Mental Health Screening and Enhanced Practices SO MILITARY MEDICINE LA English DT Article AB Objective: The objective of this study was to examine mental health screening practices and attitudes from both counselor and client perspectives in the U.S. Marine Corps substance abuse program. Method: This study examined mental health screening practices and attitudes of 23 substance abuse counselors and 442 clients from six Marine Corps substance abuse counseling centers. Results: After receiving training on screening and enhanced counseling practices, 76% of counselors reported that they almost always screened their clients for post-traumatic stress symptoms. Seventy-three percent of clients agreed that substance abuse counselors should ask about their clients' stress concerns. Conclusion: Overall, implementing screening for common mental disorders was feasible in this setting. Counselors may need further support to increase collaboration with mental health professionals and adapt treatment plans to address co-occurring mental health conditions. C1 [Hurtado, Suzanne L.; Crain, Jenny A.; Simon-Arndt, Cynthia M.; Highfill-McRoy, Robyn M.] US Navy, Hlth Res Ctr, Behav Sci & Epidemiol Dept, San Diego, CA 92106 USA. RP Hurtado, SL (reprint author), US Navy, Hlth Res Ctr, Behav Sci & Epidemiol Dept, 140 Sylvester Rd, San Diego, CA 92106 USA. FU Headquarters, U.S. Marine Corps under NHRC [60714] FX The authors express their sincere appreciation to all of the Marines and Marine Corps Substance Abuse Counseling Center staff for their participation and cooperation with this study. Report No. 12-04 was supported by Headquarters, U.S. Marine Corps under NHRC Work Unit No. 60714. NR 34 TC 0 Z9 0 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD SEP PY 2012 VL 177 IS 9 BP 1049 EP 1057 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA V33OC UT WOS:000209027100009 PM 23025134 ER PT J AU MacGregor, AJ Mayo, JA Dougherty, AL Girard, PJ Galarneau, MR AF MacGregor, Andrew J. Mayo, Jonathan A. Dougherty, Amber L. Girard, Paul J. Galarneau, Michael R. TI Injuries sustained in noncombat motor vehicle accidents during Operation Iraqi Freedom SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED LA English DT Article DE Injury; Motor vehicle accident; Operation Iraqi Freedom; Military; Noncombat ID ENDURING-FREEDOM; MECHANISMS; CASUALTIES; SEVERITY; VIETNAM; DISEASE; TRAUMA; NAVY; WAR AB Objective: To examine injuries sustained in noncombat motor vehicle accidents (MVAs) during Operation Iraqi Freedom by injury type, site, and severity. Methods: Three hundred and forty-eight military personnel injured in noncombat MVAs from March 2004-June 2007 were identified from clinical records completed near the point of injury. Results: On average, personnel suffered two injuries per accident. The most frequent MVA mechanism was non-collision due to loss of control (30%). Overall, 16% were injured in a collision accident and 19% in a rollover accident. Rollovers were associated with more severe injuries. A greater proportion of drivers sustained head/neck/face injuries, whereas gunners and pedestrians had higher percents of extremity injuries. Conclusions: This analysis provides a thorough overview of injuries incurred in nonbattle MVAs in the combat environment. Future research should combine injury data with accident reports to elucidate areas for improvements in vehicle safety. (C) 2011 Elsevier Ltd. All rights reserved. C1 [MacGregor, Andrew J.; Mayo, Jonathan A.; Dougherty, Amber L.; Galarneau, Michael R.] USN, Hlth Res Ctr, Dept Med Modeling Simulat & Mission Support, San Diego, CA 92106 USA. [Girard, Paul J.] Univ Calif San Diego, Dept Orthoped Surg, San Diego, CA 92103 USA. RP Mayo, JA (reprint author), USN, Hlth Res Ctr, Dept Med Modeling Simulat & Mission Support, 140 Sylvester Rd, San Diego, CA 92106 USA. EM jonathan.mayo@med.navy.mil FU US Navy Bureau of Medicine [60808] FX The authors thank Science Applications International Corporation, Inc., for its contributions to this work. This work was supported by the US Navy Bureau of Medicine under the Wounded, Ill and Injured/Psychological Health/Traumatic Brain Injury Program, Work Unit No. 60808. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of Defense, or the US Government. Approved for public release; distribution is unlimited. This research has been conducted in compliance with all applicable federal regulations governing the protection of human subjects in research (Protocol NHRC.2003.0025). NR 23 TC 4 Z9 4 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0020-1383 J9 INJURY JI Injury-Int. J. Care Inj. PD SEP PY 2012 VL 43 IS 9 BP 1551 EP 1555 DI 10.1016/j.injury.2011.04.017 PG 5 WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery GA 977MK UT WOS:000306666100040 PM 21612779 ER PT J AU Todd, CS Nasir, A Mansoor, GF Sahibzada, SM Jagodzinski, LL Salimi, F Khateri, MN Hale, BR Barthel, RV Scott, PT AF Todd, Catherine S. Nasir, Abdul Mansoor, G. Farooq Sahibzada, Sayed M. Jagodzinski, Linda L. Salimi, Farzana Khateri, M. Naim Hale, Braden R. Barthel, R. Vincent Scott, Paul T. TI Cross-sectional assessment of prevalence and correlates of blood-borne and sexually-transmitted infections among Afghan National Army recruits SO BMC INFECTIOUS DISEASES LA English DT Article DE Afghanistan; Military populations; HIV; Sexual risk behavior; Drug use ID FEMALE SEX WORKERS; HEPATITIS-B; MILITARY PERSONNEL; RISK BEHAVIORS; CONDOM USE; HIV RISK; INTERVENTION; SOLDIERS; DISEASES; TRENDS AB Background: Few data are available in Afghanistan to shape national military force health practices, particularly with regard to sexually-transmitted infections (STIs). We measured prevalence and correlates of HIV, syphilis, herpes simplex 2 virus (HSV-2), and hepatitis C virus (HCV) among Afghan National Army (ANA) recruits. Methods: A cross-sectional sample of male ANA recruits aged 18-35 years were randomly selected at the Kabul Military Training Center between February 2010 and January 2011. Participants completed an interviewer-administered questionnaire and serum-based rapid testing for syphilis and hepatitis C virus antibody on-site; HIV and HSV-2 screening, and confirmatory testing were performed off-site. Prevalence of each infection was calculated and logistic regression analysis performed to identify correlates. Results: Of 5313 recruits approached, 4750 consented to participation. Participants had a mean age of 21.8 years (SD +/- 3.8), 65.5% had lived outside Afghanistan, and 44.3% had no formal education. Few reported prior marijuana (16.3%), alcohol (5.3%), or opiate (3.4%) use. Of sexually active recruits (58.7%, N = 2786), 21.3% reported paying women for sex and 21.3% reported sex with males. Prevalence of HIV (0.063%, 95% CI: 0.013- 0.19), syphilis (0.65%, 95% CI: 0.44 - 0.93), and HCV (0.82%, 95% CI: 0.58 - 1.12) were quite low. Prevalence of HSV-2 was 3.03% (95% CI: 2.56 - 3.57), which was independently associated with age (Adjusted Odds Ratio (AOR) = 1.04, 95% CI: 1.00 - 1.09) and having a television (socioeconomic marker) (AOR = 1.46, 95% CI: 1.03 - 2.05). Conclusion: Though prevalence of HIV, HCV, syphilis, and HSV-2 was low, sexual risk behaviors and intoxicant use were present among a substantial minority, indicating need for prevention programming. Formative work is needed to determine a culturally appropriate approach for prevention programming to reduce STI risk among Afghan National Army troops. C1 [Todd, Catherine S.] Columbia Univ, Dept Obstet & Gynecol, New York, NY 10032 USA. [Nasir, Abdul; Mansoor, G. Farooq; Sahibzada, Sayed M.] Hlth Protect & Res Org, Taimany, Kabul, Afghanistan. [Jagodzinski, Linda L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Salimi, Farzana] Minist Publ Hlth, Afghan Publ Hlth Inst, Kabul, Afghanistan. [Khateri, M. Naim] Minist Def, Shash Darak, Kabul, Afghanistan. [Hale, Braden R.] USN, Hlth Res Ctr, Dept Def, HIV AIDS Prevent Program, San Diego, CA 92106 USA. [Barthel, R. Vincent] US NAMRU 3, Cairo, Egypt. [Scott, Paul T.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. RP Todd, CS (reprint author), Columbia Univ, Dept Obstet & Gynecol, 622 W 168th St,PH 16-69, New York, NY 10032 USA. EM cst2121@columbia.edu FU Walter Reed Army Institute of Research FX This study was funded by the Walter Reed Army Institute of Research. Material has been reviewed by the Walter Reed Army Institute of Research. There is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the authors, and are not to be construed as official, or as reflecting true views of the United States Department of the Army or the Department of Defense. NR 28 TC 5 Z9 5 U1 0 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD AUG 21 PY 2012 VL 12 AR 196 DI 10.1186/1471-2334-12-196 PG 9 WC Infectious Diseases SC Infectious Diseases GA 027KQ UT WOS:000310351500001 PM 22909128 ER PT J AU Reed, JB Njeuhmeli, E Thomas, AG Bacon, MC Bailey, R Cherutich, P Curran, K Dickson, K Farley, T Hankins, C Hatzold, K Justman, J Mwandi, Z Nkinsi, L Ridzon, R Ryan, C Bock, N AF Reed, Jason Bailey Njeuhmeli, Emmanuel Thomas, Anne Goldzier Bacon, Melanie C. Bailey, Robert Cherutich, Peter Curran, Kelly Dickson, Kim Farley, Tim Hankins, Catherine Hatzold, Karin Justman, Jessica Mwandi, Zebedee Nkinsi, Luke Ridzon, Renee Ryan, Caroline Bock, Naomi TI Voluntary Medical Male Circumcision: An HIV Prevention Priority for PEPFAR SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE male circumcision; HIV prevention; PEPFAR ID RANDOMIZED CONTROLLED-TRIAL; IMMUNODEFICIENCY-VIRUS TYPE-1; HUMAN-PAPILLOMAVIRUS; FEMALE PARTNERS; TARGET-CELLS; YOUNG MEN; INFECTION; RISK; TRANSMISSION; KISUMU AB As the science demonstrating strong evidence for voluntary medical male circumcision (VMMC) for HIV prevention has evolved, the President's Emergency Plan for AIDS Relief (PEPFAR) has collaborated with international agencies, donors, and partner country governments supporting VMMC programming. Mathematical models forecast that quickly reaching a large number of uncircumcised men with VMMC in strategically chosen populations may dramatically reduce community-level HIV incidence and save billions of dollars in HIV care and treatment costs. Because VMMC is a 1-time procedure that confers life-long partial protection against HIV, programs for adult men are vital short-term investments with long-term benefits. VMMC also provides a unique opportunity to reach boys and men with HIV testing and counseling services and referrals for other HIV services, including treatment. After formal recommendations by WHO in 2007, priority countries have pursued expansion of VMMC. More than 1 million males have received VMMC thus far, with the most notable successes coming from Kenya's Nyanza Province. However, a myriad of necessary cultural, political, and ethical considerations have moderated the pace of overall success. Because many millions more uncircumcised men would benefit from VMMC services now, US President Barack Obama committed PEPFAR to provide 4.7 million males with VMMC by 2014. Innovative circumcision methods-such as medical devices that remove the foreskin without injected anesthesia and/or sutures-are being rigorously evaluated. Incorporation of safe innovations into surgical VMMC programs may provide the opportunity to reach more men more quickly with services and dramatically reduce HIV incidence for all. C1 [Reed, Jason Bailey; Bock, Naomi] US Ctr Dis Control & Prevent, Atlanta, GA USA. [Njeuhmeli, Emmanuel] US Agcy Int Dev, Washington, DC 20523 USA. [Thomas, Anne Goldzier] USN, Hlth Res Ctr, Dept Def HIV AIDS Program, San Diego, CA 92152 USA. [Bacon, Melanie C.] US Natl Inst Hlth, Bethesda, MD USA. [Bailey, Robert] Univ Illinois, Sch Publ Hlth, Chicago, IL USA. [Curran, Kelly] Johns Hopkins Bloomberg Sch Publ Hlth, Jhpiego, Baltimore, MD USA. [Dickson, Kim] UNICEF, Hlth Sect, New York, NY USA. [Farley, Tim] WHO, Sigma3 Serv, Nyon, Switzerland. [Hankins, Catherine] London Sch Hyg & Trop Med, Geneva, Switzerland. [Hankins, Catherine] Joint United Nations Programme HIV AIDS, Geneva, Switzerland. [Justman, Jessica] Columbia Univ, Mailman Sch Publ Hlth, Int Ctr AIDS Care & Treatment Programs, New York, NY USA. [Mwandi, Zebedee] US Ctr Dis Control & Prevent Kenya, Nairobi, Kenya. [Ridzon, Renee] Bill & Melinda Gates Fdn, Ahimsa Grp LLC, Seattle, WA USA. [Ryan, Caroline] Off Global AIDS Coordinator, Washington, DC USA. RP Reed, JB (reprint author), 1600 Clifton Rd NE,MS E-04, Atlanta, GA 30333 USA. EM jreed1@cdc.gov OI Hankins, Catherine/0000-0002-1642-8592 FU PEPFAR FX Various authors receive financial support or have professional relationships from PEPFAR (either as employees of PEPFAR-supported US Government agencies or as grantees/contractors) as outlined in the Copyright Transfer Agreement Forms. NR 54 TC 15 Z9 15 U1 0 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD AUG 15 PY 2012 VL 60 SU 3 BP S88 EP S95 DI 10.1097/QAI.0b013e31825cac4e PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 981TR UT WOS:000306994100007 PM 22797745 ER PT J AU Irvin, DJ Stenger-Smith, JD Yandek, GR Carberry, JR Currie, DA Theodoropoulou, N Irvin, JA AF Irvin, David J. Stenger-Smith, John D. Yandek, Gregory R. Carberry, Jamie R. Currie, Daniel A. Theodoropoulou, Nikoleta Irvin, Jennifer A. TI Enhanced electrochemical response of solution-deposited n-doping polymer via cocasting with ionic liquid SO JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS LA English DT Article DE co-casting; electroactive polymer; conducting polymers; electrochemistry; morphology; ion mobility; ionic liquid; n-doping ID QUARTZ-CRYSTAL MICROBALANCE; LADDER POLYMERS; CONDUCTING POLYMERS; FILMS; TRANSPORT; REDOX; STATE; BBL AB A novel cocasting approach is presented for improving electroactivity of solution-cast films of conducting polymers. Solutions of the n-doping polymer poly(benzimidazobenzophenanthroline) (BBL) were co-deposited with the ionic liquid electrolyte 1-ethyl-3-methyl-imidazolium bis(trifluoromethylsulfonyl)imide (EMIBTI). The resultant co-continuous mixture yielded highly porous polymer films (CC-BBL) upon removal of solvent and EMIBTI. Electrochemical quartz crystal microgravimetry revealed that the n-doping process in neat ionic liquid is anion-dominant, which is contrary to what is observed in dilute electrolyte solutions. The CC-BBL films exhibit a thirty-fold increase in initial current response and capacity relative to non-cocast BBL films. While current response and capacity of the non-cocast BBL improve with cycling, they level out after 800 cycles at 35% of those of the CC-BBL. CC-BBL shows high n-doping stability; no decrease in electroactivity is seen after 1000 cycles. (c) 2012 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2012 C1 [Carberry, Jamie R.; Currie, Daniel A.; Theodoropoulou, Nikoleta; Irvin, Jennifer A.] SW Texas State Univ, Coll Sci, San Marcos, TX 78666 USA. [Irvin, David J.] Syst & Mat Res Corp, Austin, TX 78756 USA. [Stenger-Smith, John D.] USN, Res Dept, Air Warfare Ctr, Weap Div, China Lake, CA 93555 USA. [Yandek, Gregory R.] USAF, Prop Mat Applicat Branch, Res Lab, Prop Directorate Edwards AFB, Edwards AFB, CA 93524 USA. RP Irvin, JA (reprint author), SW Texas State Univ, Coll Sci, 601 Univ Dr, San Marcos, TX 78666 USA. EM jennifer.irvin@txstate.edu RI Irvin, Jennifer/C-7968-2013 OI Irvin, Jennifer/0000-0003-3500-8419 FU Office of Naval Research; ACS PRF [50120-UNI10] FX The authors thank the Office of Naval Research (Drs. M. Anderson and P. Armistead) and ACS PRF (grant #50120-UNI10) for the financial support of this project. (Supporting Information is available online from Wiley InterScience or from the author). Helpful suggestions from the reviewers are also appreciated. NR 40 TC 5 Z9 5 U1 1 U2 28 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0887-6266 J9 J POLYM SCI POL PHYS JI J. Polym. Sci. Pt. B-Polym. Phys. PD AUG 15 PY 2012 VL 50 IS 16 BP 1145 EP 1150 DI 10.1002/polb.23111 PG 6 WC Polymer Science SC Polymer Science GA 969TV UT WOS:000306082700001 ER PT J AU Davis, MC Groshens, TJ AF Davis, Matthew C. Groshens, Thomas J. TI Nitration of tert-butyloxycarbonylated aniline and 1,3,5-triaminobenzene by acetyl nitrate SO TETRAHEDRON LETTERS LA English DT Article DE Aromatic nitration; Acetyl nitrate; Aniline; Boc-protection ID REGIOSELECTIVE NITRATION; AROMATIC-SUBSTITUTION; ACID; REARRANGEMENT; ACETANILIDES; PRECURSOR; MECHANISM; GLUTAMATE AB Acetyl nitrate was found to be an effective reagent for aromatic mono- and dinitration of Boc-protected aminobenzenes. The method was used in a new synthesis of 1,35-triamino-2,4-dinitrobenzene in two steps with 63% yield. Published by Elsevier Ltd. C1 [Davis, Matthew C.; Groshens, Thomas J.] USN, Chem & Mat Div, Air Warfare Ctr, China Lake, CA 93555 USA. RP Davis, MC (reprint author), USN, Chem & Mat Div, Air Warfare Ctr, China Lake, CA 93555 USA. EM matthew.davis@navy.mil FU Office of Naval Research FX Financial support through an In-house Laboratory Independent Research award from the Office of Naval Research is gratefully acknowledged. NR 30 TC 1 Z9 1 U1 3 U2 25 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0040-4039 J9 TETRAHEDRON LETT JI Tetrahedron Lett. PD AUG 8 PY 2012 VL 53 IS 32 BP 4154 EP 4155 DI 10.1016/j.tetlet.2012.05.139 PG 2 WC Chemistry, Organic SC Chemistry GA 978SN UT WOS:000306766200030 ER PT J AU Norris, JN Viirre, E Aralis, H Sracic, MK Thomas, D Gertsch, JH AF Norris, Jacob N. Viirre, Erik Aralis, Hilary Sracic, Michael K. Thomas, Darren Gertsch, Jeffery H. TI High Altitude Headache and Acute Mountain Sickness at Moderate Elevations in a Military Population During Battalion-Level Training Exercises SO MILITARY MEDICINE LA English DT Article AB Few studies have evaluated high altitude headache (HAH) and acute mountain sickness (AMS) in military populations training at moderate (1,500-2,500 m) to high altitudes (>2,500 m). In the current study, researchers interviewed active duty personnel training at Marine Corps Mountain Warfare Training Center. Participants were asked about HA}{and AMS symptoms, potential risk factors, and medications used. In a sample of 192 U.S. Navy and Marine Corps personnel, 14.6% reported AMS (Lake Louise Criteria >= 3) and 28.6% reported HAH. Dehydration and recent arrival at altitude (defined as data collected on days 2-3) were significantly associated with AMS; decreased sleep allowance was significantly associated with HAH. Although ibuprofen/Motrin users were more likely to screen positive for AMS, among AMS-positive participants, ibuprofen/Motrin users had decreased likelihood of reporting robust AMS relative to non-ibuprofen/Motrin users (p < 0.01). These results suggest that maintenance of hydration and adequate sleep allowance may be critical performance requirements at altitude. Further, ibuprofen/Motrin may be a reasonable treatment for the symptoms of AMS and HAH, although further study is warranted. C1 [Norris, Jacob N.; Viirre, Erik; Aralis, Hilary] Naval Hlth Res Ctr, Warfighter Performance Dept, San Diego, CA 92106 USA. [Sracic, Michael K.] Battal Surg Off, Camp Pendleton, CA 92055 USA. [Thomas, Darren] Marine Corps Mt Warfare Training Ctr, OIC Mt & Cold Weather Med, Bridgeport, CA 93517 USA. [Gertsch, Jeffery H.] Univ Calif San Diego, Sch Med, Dept Neurosci, La Jolla, CA 92093 USA. RP Norris, JN (reprint author), Naval Hlth Res Ctr, Warfighter Performance Dept, 140 Sylvester Rd, San Diego, CA 92106 USA. FU Navy Bureau of Medicine and Surgery [61031] FX The authors would like to thank COL Philip Chandler, Commanding Officer, Mountain Warfare Training Center, and Lt Col C.R. Wonson, Commanding Officer, 1st Battalion, 1st Marines; and Mr. Christopher Henson for acting as liaison to the Marines. This report was supported by Navy Bureau of Medicine and Surgery, under Work Unit No. 61031. NR 48 TC 1 Z9 4 U1 0 U2 9 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2012 VL 177 IS 8 BP 917 EP 923 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA V33OA UT WOS:000209026900009 PM 22934370 ER PT J AU Crum-Cianflone, NF Kathiria, N Shauger, S Love, K Boswell, G AF Crum-Cianflone, Nancy F. Kathiria, Nazima Shauger, Susan Love, Kathleen Boswell, Gilbert TI The association of epicardial adipose tissue with coronary artery calcification among HIV-infected men SO AIDS LA English DT Article ID CARDIOVASCULAR RISK; HEART-DISEASE; FAT; THICKNESS AB Little data exist regarding the association of epicardial adipose tissue (EAT) and cardiovascular disease among HIV-infected persons. Among 213 HIV-infected men, there was a significant association between protease inhibitor use and increasing EAT volume. EAT was significantly associated with coronary artery calcium greater than 100. The elevated coronary artery disease risk in HIV-infected men may be partially explained by EAT associated with protease inhibitor use. C1 [Crum-Cianflone, Nancy F.] USN, San Diego Med Ctr, Infect Dis Clin, San Diego, CA 92134 USA. [Crum-Cianflone, Nancy F.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Crum-Cianflone, Nancy F.] Naval Hlth Res Ctr, San Diego, CA USA. [Kathiria, Nazima; Shauger, Susan; Boswell, Gilbert] USN, San Diego Med Ctr, Dept Radiol, San Diego, CA 92134 USA. [Love, Kathleen] USN, San Diego Med Ctr, Dept Cardiol, San Diego, CA 92134 USA. RP Crum-Cianflone, NF (reprint author), USN, San Diego Med Ctr, Infect Dis Clin, 34800 Bob Wilson Dr,Ste 5, San Diego, CA 92134 USA. EM nancy.crum@med.navy.mil FU Infectious Disease Clinical Research Program (IDCRP), Department of Defense (DoD) [IDCRP-018]; National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) [Y1-AI-5072] FX Support for this work (IDCRP-018) was provided by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072. NR 15 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0269-9370 J9 AIDS JI Aids PD JUL 31 PY 2012 VL 26 IS 12 BP 1573 EP 1576 DI 10.1097/QAD.0b013e328355cef8 PG 4 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 977NN UT WOS:000306670300016 PM 22713476 ER PT J AU Wu, CT Valls, OT Halterman, K AF Wu, Chien-Te Valls, Oriol T. Halterman, Klaus TI Proximity effects and triplet correlations in ferromagnet/ferromagnet/superconductor nanostructures SO PHYSICAL REVIEW B LA English DT Article ID SUPERCONDUCTOR-FERROMAGNET STRUCTURES; SUPERCURRENTS; METALS; FIELD AB We report the results of a study of superconducting proximity effects in clean ferromagnet/ferromagnet/ superconductor (F1F2S) heterostructures, where the pairing state in S is a conventional singlet s-wave. We numerically find the self-consistent solutions of the Bogoliubov-de Gennes (BdG) equations and use these solutions to calculate the relevant physical quantities. By linearizing the BdG equations, we obtain the superconducting transition temperatures T-c as a function of the angle alpha between the exchange fields in F-1 and F-2. We find that the results for T-c (alpha) in F1F2S systems are clearly different from those in F1SF2 systems, where T-c monotonically increases with alpha and is highest for antiparallel magnetizations. Here, T-c(alpha) is in general a nonmonotonic function, and often has a minimum near alpha approximate to 80 degrees. For certain values of the exchange field and layer thicknesses, the system exhibits reentrant superconductivity with alpha: it transitions from superconducting to normal, and then returns to a superconducting state again with increasing alpha. This phenomenon is substantiated by a calculation of the condensation energy. We compute, in addition to the ordinary singlet pair amplitude, the induced odd triplet pairing amplitudes. The results indicate a connection between equal-spin triplet pairing and the singlet pairing state that characterizes T-c. We find also that the induced triplet amplitudes can be very long ranged in both the S and F sides and characterize their range. We discuss the average density of states for both the magnetic and the S regions, and its relation to the pairing amplitudes and T-c. The local magnetization vector, which exhibits reverse proximity effects, is also investigated. C1 [Wu, Chien-Te; Valls, Oriol T.] Univ Minnesota, Sch Phys & Astron, Minneapolis, MN 55455 USA. [Halterman, Klaus] USN, Michelson Lab, Div Phys, Air Warfare Ctr, China Lake, CA 93555 USA. [Valls, Oriol T.] Univ Minnesota, Minnesota Supercomp Inst, Minneapolis, MN 55455 USA. RP Wu, CT (reprint author), Univ Minnesota, Sch Phys & Astron, Minneapolis, MN 55455 USA. EM wu@physics.umn.edu; otvalls@umn.edu; klaus.halterman@navy.mil OI Halterman, Klaus/0000-0002-6355-3134 FU ONR; DOD (HPCMP) FX We thank C. Grasse and B. Benton for technical help. K.H. is supported in part by ONR and by grants of HPC resources from DOD (HPCMP). NR 53 TC 19 Z9 19 U1 1 U2 7 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9950 EI 2469-9969 J9 PHYS REV B JI Phys. Rev. B PD JUL 31 PY 2012 VL 86 IS 1 AR 014523 DI 10.1103/PhysRevB.86.014523 PG 13 WC Physics, Condensed Matter SC Physics GA 981SQ UT WOS:000306991300001 ER PT J AU Seelig, AD Jacobson, IG Smith, B Hooper, TI Gackstetter, GD Ryan, MAK Wells, TS Wadsworth, SM Smith, TC AF Seelig, Amber D. Jacobson, Isabel G. Smith, Besa Hooper, Tomoko I. Gackstetter, Gary D. Ryan, Margaret A. K. Wells, Timothy S. Wadsworth, Shelley MacDermid Smith, Tyler C. CA Millennium Cohort Study Team TI Prospective Evaluation of Mental Health and Deployment Experience Among Women in the US Military SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Article DE anxiety disorders; depression; military personnel; panic disorder; stress disorders; post-traumatic; women ID UK ARMED-FORCES; MILLENNIUM COHORT; ALCOHOL-USE; GENDER-DIFFERENCES; COMBAT DEPLOYMENT; SLEEP DISTURBANCE; SERVICE MEMBERS; SOCIAL SUPPORT; PRIMARY-CARE; FOLLOW-UP AB Previous research has shown that military women often experience potentially severe health outcomes following deployment. Data from the Millennium Cohort Study, a 21-year longitudinal study examining the health effects of military service, were used to examine this issue. In longitudinal analyses (20012008) carried out among US military women (n 17,481), the authors examined positive screens for depression, anxiety, panic, and posttraumatic stress disorder in relation to deployment in support of the operations in Iraq and Afghanistan, while adjusting for relevant baseline and time-varying covariates. Women who were deployed and reported combat-related exposures had greater odds than nondeployed women of reporting symptoms of a mental health condition (odds ratio 1.91, 95 confidence interval: 1.65, 2.20), after adjustment for demographic, military, and behavioral covariates. In addition, higher stress, problem drinking, and a history of mental illness were significantly associated with increased risk of later mental health conditions. In contrast, women in the Reserves or National Guard and those with higher education were at decreased risk of mental health conditions (all P s 0.01). As the roles and responsibilities of women in the military expand and deployments continue, designing better prevention and recovery strategies specifically for women are critical for overall force health protection and readiness. C1 [Seelig, Amber D.; Jacobson, Isabel G.; Smith, Besa; Wells, Timothy S.; Smith, Tyler C.] USN, Deployment Hlth Res Dept, Hlth Res Ctr, San Diego, CA 92106 USA. [Hooper, Tomoko I.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Gackstetter, Gary D.] Analyt Serv Inc, Arlington, VA USA. [Ryan, Margaret A. K.] USN, Hosp Camp Pendleton, Camp Pendleton, CA USA. [Wadsworth, Shelley MacDermid] Purdue Univ, Human Dev & Family Studies Dept, Mil Family Res Inst, W Lafayette, IN 47907 USA. RP Seelig, AD (reprint author), USN, Deployment Hlth Res Dept, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. EM amber.seelig@med.navy.mil RI MacDermid Wadsworth, Shelley/G-1322-2011 OI MacDermid Wadsworth, Shelley/0000-0002-5443-2760 FU Military Operational Medicine Research Program of the US Army Medical Research; Materiel Command, Fort Detrick, Maryland; Department of Defense FX This work was supported by the Military Operational Medicine Research Program of the US Army Medical Research and Materiel Command, Fort Detrick, Maryland.; This article represents report 11-23, supported by the Department of Defense under work unit 60002. The research was conducted in compliance with all applicable federal regulations governing the protection of human subjects in research (protocol NHRC.2000.0007). The article is approved for public release; distribution is unlimited. NR 59 TC 11 Z9 11 U1 2 U2 13 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUL 15 PY 2012 VL 176 IS 2 BP 135 EP 145 DI 10.1093/aje/kwr496 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 974CD UT WOS:000306406500008 PM 22771728 ER PT J AU Davis, MC Groshens, TJ AF Davis, Matthew C. Groshens, Thomas J. TI Dimerization of resveratrol trimethyl ether by phosphotungstic acid, structure confirmation of resformicol A and B SO TETRAHEDRON LETTERS LA English DT Article DE Resveratrol trimethyl ether; Phosphotungstic acid; Tetralins; Dimerization ID CYCLODIMERIZATION; PHLOROGLUCINOL; FORMALDEHYDE; STILBENES AB Dimerization of the trimethyl ether of resveratrol catalyzed by phosphotungstic acid gave two tetralins and a naphthalene derivative. The structure of the tetralins was obtained by X-ray crystallography and confirms the reported stereochemical configuration of resformicol A and B. Published by Elsevier Ltd. C1 [Davis, Matthew C.; Groshens, Thomas J.] USN, Air Warfare Ctr, Chem & Mat Div, China Lake, CA 93555 USA. RP Davis, MC (reprint author), USN, Air Warfare Ctr, Chem & Mat Div, China Lake, CA 93555 USA. EM matthew.davis@navy.mil FU Office of Naval Research FX Financial support through an In-house Laboratory Independent Research award from the Office of Naval Research is gratefully acknowledged. NR 31 TC 1 Z9 1 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0040-4039 J9 TETRAHEDRON LETT JI Tetrahedron Lett. PD JUL 4 PY 2012 VL 53 IS 27 BP 3521 EP 3523 DI 10.1016/j.tetlet.2012.04.132 PG 3 WC Chemistry, Organic SC Chemistry GA 970SL UT WOS:000306152500029 ER PT J AU Crum-Cianflone, NF Grandits, G Weintrob, A Ganesan, A Agan, B Landrum, M AF Crum-Cianflone, N. F. Grandits, G. Weintrob, A. Ganesan, A. Agan, B. Landrum, M. TI Skin and soft tissue infections among HIV-infected persons in the late combination antiretroviral therapy era SO INTERNATIONAL JOURNAL OF STD & AIDS LA English DT Article DE HIV; skin and soft tissue infection; SSTI; MRSA; epidemiology; risk factors ID RESISTANT STAPHYLOCOCCUS-AUREUS; RISK-FACTORS; MRSA BACTEREMIA; MEN; SEX; COLONIZATION; COHORT AB Skin and soft tissue infections (SSTIs) occur at higher rates among HIV-infected persons, but current trends and risk factors are largely undefined. We evaluated SSTIs among a prospective cohort of HIV-infected persons during the late combination antiretroviral therapy (cART) era (2006-2010). Of the 1918 HIV-infected persons evaluated, 379 (20%) developed an SSTI during a median of 3.7 years of follow-up; of these, 118 (31%) developed at least one recurrent SSTI. The incidence rate of SSTIs was 101 (95% confidence interval [CI] 93-109) cases per 1000 person-years, and rates did not significantly change during the study period. Compared with not receiving cART and having an HIV RNA level >1000 copies/mL, patients receiving cART with an HIV RNA level <1000 copies/mL had a reduced risk of an SSTI (hazard ratio 0.64, 95% Cl 0.48-0.86, P < 0.01). In summary, initial and recurrent SSTIs are common among HIV-infected persons, and HIV control is associated with a lower risk of SSTIs. C1 [Crum-Cianflone, N. F.; Agan, B.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Crum-Cianflone, N. F.] USN, Infect Dis Clin, San Diego Med Ctr, San Diego, CA 92152 USA. [Crum-Cianflone, N. F.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Grandits, G.] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Weintrob, A.; Ganesan, A.] Walter Reed Natl Mil Med Ctr, Infect Dis Clin, Bethesda, MD USA. [Landrum, M.] San Antonio Mil Med Ctr, Infect Dis Serv, San Antonio, TX USA. RP Crum-Cianflone, NF (reprint author), Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. EM nancy.crum@med.nayy.mil OI Agan, Brian/0000-0002-5114-1669 FU Infectious Disease Clinical Research Program (IDCRP) [IDCRP-000-16]; Department of Defense (DoD) programme executed through Uniformed Services University of the Health Sciences; National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) [Y1-AI-5072] FX Support for this work (IDCRP-000-16) was provided by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) programme executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072. The content and views expressed in this publication is the sole responsibility of the authors and does not necessarily reflect the views or policies of the NTH or the Department of Health and Human Services, the DoD or the Departments of the Army, Navy, Air Force, Department of Defense, nor the US Government. Mention of trade names, commercial products, or organizations does not imply endorsement by the US Government. The authors acknowledge that research protocol ('Trends and Causes of Hospitalizations among HIV-Infected Persons in the HAART Era', IDCRP #28) received applicable Institutional Review Board review and approval. We certify that all individuals who qualify as authors have been listed; each has participated in the conception and design of this work, the analysis of data, the writing of the document, and the approval of the submission of this version; that the document represents valid work; that if we used information derived from another source, we obtained all necessary approvals to use it and made appropriate acknowledgements in the document; and that each takes public responsibility for it. Nothing in the presentation implies any Federal/DOD/DON endorsement. NR 20 TC 4 Z9 4 U1 0 U2 0 PU ROYAL SOC MEDICINE PRESS LTD PI LONDON PA 1 WIMPOLE STREET, LONDON W1G 0AE, ENGLAND SN 0956-4624 J9 INT J STD AIDS JI Int. J. STD AIDS PD JUL PY 2012 VL 23 IS 7 BP 507 EP 511 DI 10.1258/ijsa.2011.011360 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 988MD UT WOS:000307494200011 PM 22844006 ER PT J AU Hourani, L Bender, RH Weimer, B Peeler, R Bradshaw, M Lane, M Larson, G AF Hourani, Laurel Bender, Randall H. Weimer, Belinda Peeler, Russ Bradshaw, Michael Lane, Marian Larson, Gerald TI Longitudinal study of resilience and mental health in marines leaving military service SO JOURNAL OF AFFECTIVE DISORDERS LA English DT Article DE Longitudinal; Mental health; PTSD; Resilience; Military; Combat exposure ID PRIMARY-CARE; SCALE; POLYMORPHISM; DEPRESSION; DEPLOYMENT; DISORDER; STRESS; SENSE; GENE AB Background: Despite a growing emphasis on psychological outcomes following military combat, few longitudinal studies have examined the combined role of risk and protective factors in the mental health of combat-exposed military personnel. This study characterizes the impact of resilience scale scores and combat exposure on mental health outcomes among Marines after separating from military service, along with intra-individual changes in mental health status. Methods: Data were collected from longitudinal surveys of 475 active duty Marines attending a random sample of mandatory Transition Assistance Program workshops before leaving the military and responding to follow-up mail or web surveys an average of 6 months after returning to civilian life. Results: Results revealed distinct risk and protective factors for those meeting screening criteria for mental health problems (depression, anxiety, and PTSD) and functional impairment at follow-up. Primary risk factors included experiencing higher levels of pre-separation combat exposure; post-separation stress across multiple life domains; and experiencing multiple areas of pain post-separation. Protective factors include having higher scores on pre-separation resilience and perceived social support at follow-up indices. We also identified a number of factors associated with change in mental health status from baseline to follow-up. Limitations: Generality is limited by a lower than expected follow-up response rate and an exclusively Marine sample. Conclusion: The role of resilience appeared to have a greater impact on functional impairment than on mental health symptoms per se. Findings provide important input for enhancing training programs and services intended to promote adjustment from military to civilian life. Additional emphasis on social support and coping with stress-related issues are needed in support of combat veterans. (C) 2012 Elsevier B.V. All rights reserved. C1 [Hourani, Laurel; Bender, Randall H.; Weimer, Belinda; Peeler, Russ; Bradshaw, Michael; Lane, Marian] RTI Int, Virginia Beach, VA 23453 USA. [Larson, Gerald] USN, Hlth Res Ctr, San Diego, CA 92152 USA. RP Hourani, L (reprint author), RTI Int, 2769 Pleasant Acres Dr, Virginia Beach, VA 23453 USA. EM Hourani@rti.org FU Naval Health Research Center [W911QY-08-D-0021/DO3] FX This study was supported by the Naval Health Research Center contract number W911QY-08-D-0021/DO3. NR 36 TC 15 Z9 16 U1 1 U2 26 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-0327 J9 J AFFECT DISORDERS JI J. Affect. Disord. PD JUL PY 2012 VL 139 IS 2 BP 154 EP 165 DI 10.1016/j.jad.2012.01.008 PG 12 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 975TV UT WOS:000306535300006 PM 22381952 ER PT J AU Broderick, MP Hansen, CJ Faix, DJ AF Broderick, Michael P. Hansen, Christian J. Faix, Dennis J. TI Factors Associated With Loss of Penicillin G Concentrations in Serum After Intramuscular Benzathine Penicillin G Injection: A Meta-analysis SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE benzathine penicillin G; group A streptococcus; prophylaxis; meta-analysis; systematic review ID RHEUMATIC-FEVER PROPHYLAXIS; EVERY 4 WEEKS; GROUP-A STREPTOCOCCI; PREVENTION; PHARYNGITIS; CHILDREN; PHARMACOKINETICS; RECURRENCES; REGIMENS; 3-WEEK AB Background: An interval of 3-4 weeks between intramuscular injections of 1.2 million units of benzathine penicillin G as prophylaxis against group A streptococcal infection is recommended by health organizations for patients with pediatric rheumatic fever and heart disease. Methods: We reviewed the literature for evidence of the persistence of serum penicillin G during the first 4 weeks after the recommended dose of benzathine penicillin G. Results: The weighted-mean concentration was <0.02 mu g/mL by 3 weeks after the initial dose. Weighted means were lower in studies done after 1990 than before (P < 0.01), in studies dealing with secondary versus primary prophylaxis (P < 0.01) and in studies in children versus those in adults (P < 0.02). Conclusions: Recommendations for benzathine penicillin G prophylaxis may need reevaluation. C1 [Broderick, Michael P.; Hansen, Christian J.] USN, Henry M Jackson Fdn, Operat Infect Dis Dept, Hlth Res Ctr, San Diego, CA 92106 USA. RP Broderick, MP (reprint author), USN, Dept Resp Med, Hlth Res Ctr, San Diego, CA 92106 USA. EM michael.broderick@med.navy.mil RI Valle, Ruben/A-7512-2013 FU Armed Forces Health Surveillance Center's Global Emerging Infections Surveillance and Response System FX This study was supported by the Armed Forces Health Surveillance Center's Global Emerging Infections Surveillance and Response System. The sponsor of the study had no role in study design, data collection, data analysis, data interpretation or writing of the report. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of Defense, or the US Government. The authors have no other conflicts of interest or funding to disclose. NR 46 TC 7 Z9 7 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0891-3668 EI 1532-0987 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD JUL PY 2012 VL 31 IS 7 BP 722 EP 725 DI 10.1097/INF.0b013e31825051d4 PG 4 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA 964PJ UT WOS:000305708300012 PM 22481428 ER PT J AU Fuller, ME Schaefer, CE Andaya, C Lazouskaya, V Fallis, S Wang, C Jin, Y AF Fuller, Mark E. Schaefer, Charles E. Andaya, Christina Lazouskaya, Volha Fallis, Steve Wang, Chao Jin, Yan TI Dissolution kinetics of sub-millimeter Composition B detonation residues: Role of particle size and particle wetting SO CHEMOSPHERE LA English DT Article DE RDX; TNT; Mass transfer; Colloid; Dissolution; Composition B ID ENERGETIC MATERIALS; TRANSPORT AB The dissolution of the 2,4,6-trinitrotoluene (TNT), hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) from microscale particles (<250 mu m) of the explosive formulation Composition B was examined and compared to dissolution from macroscopic particles (>0.5 mm). The dissolution of explosives from detonation soot was also examined. The measured mass transfer coefficients for the microscale particles were one to two orders of magnitude greater than the macroscopic particles. When normalized to particle surface area, mass transfer coefficients of microscale and macroscale particles were similar, indicating that the bulk dissolution processes were similar throughout the examined size range. However, an inverse relationship was observed between the particle diameter and the RDX:TNT mass transfer rate coefficient ratio for dry-attritted particles, which suggests that RDX may be more readily dissolved (relative to TNT) in microscale particles compared to macroscale particles. Aqueous weathering of larger Composition B residue; generated particles that possessed mass transfer coefficients that were on the order of 5- to 20-fold higher than dry-attritted particles of all sizes, even when normalized to particle surface area. These aqueous weathered particles also possessed a fourfold lower absolute zeta-potential than dry-attritted particles, which is indicative that they were less hydrophobic (and hence, more wettable) than dry-attritted particles. The increased wettability of these particles provides a plausible explanation for the observed enhanced dissolution. The wetting history and the processes by which particles are produced (e.g., dry physical attrition vs. aqueous weathering) of Composition B residues should be considered when calculating mass transfer rates for fate and transport modeling. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Fuller, Mark E.; Schaefer, Charles E.; Andaya, Christina; Lazouskaya, Volha] Shaw Environm Inc, Lawrenceville, NJ 08648 USA. [Lazouskaya, Volha; Wang, Chao; Jin, Yan] Univ Delaware, Newark, DE 19716 USA. [Fallis, Steve] USN, Air Warfare Ctr, Weap Div, China Lake, CA 93555 USA. RP Fuller, ME (reprint author), Shaw Environm Inc, 17 Princess Rd, Lawrenceville, NJ 08648 USA. EM mark.fuller@shawgrp.com FU Strategic Environmental Research and Development Program (SERDP) [W912HQ-09-C0012] FX This project was supported by the Strategic Environmental Research and Development Program (SERDP) through Contract W912HQ-09-C0012. We thank the Naval Explosive Ordnance Disposal Technology Division (Blossom Point), and Dr. Susan Taylor (US Army Corps of Engineers) for providing some of the explosive materials used for this research. We would also like to acknowledge Ms. Tamara Jones of the Detonation Sciences Branch who coordinated the Composition B detonation experiments at China Lake. Views, opinions, and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of Defense position or decision unless so designated by other official documentation. NR 16 TC 3 Z9 3 U1 2 U2 11 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD JUL PY 2012 VL 88 IS 5 BP 591 EP 597 DI 10.1016/j.chemosphere.2012.03.038 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA 958SV UT WOS:000305261900009 PM 22483856 ER PT J AU Macera, CA Aralis, HJ Rauh, MJ MacGregor, A AF Macera, Caroline A. Aralis, Hilary J. Rauh, Mitchell J. MacGregor, Andrew TI Postdeployment Symptom Reporting for Blast-Related Traumatic Brain Injury and/or Posttraumatic Stress Syndrome SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract C1 [Macera, Caroline A.; Aralis, Hilary J.; Rauh, Mitchell J.; MacGregor, Andrew] Naval Hlth Res Ctr, San Diego, CA USA. EM cmacera@mail.sdsu.edu NR 0 TC 0 Z9 0 U1 1 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD JUL PY 2012 VL 27 SU 2 MA 1578 BP 355 EP 355 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA V35IG UT WOS:000209142901334 ER PT J AU Schmied, EA Highfill-McRoy, RM Larson, GE AF Schmied, Emily A. Highfill-McRoy, Robyn M. Larson, Gerald E. TI Mental Health and Turnover Following an Initial Term of Military Service SO MILITARY MEDICINE LA English DT Article AB Objective: This study compared the rates of mental disorders between Marines who re-enlisted and Marines who separated after 1 term, distinguishing between Marines who were and were not recommended for re-enlistment. Methods: Participants included 28,693 male Marines enlisting for 4-year terms between 2002 and 2003, including 9,338 who re-enlisted after 1 term, 18,177 who voluntarily separated after 1 term, and 1,184 who were not recommended for re-enlistment and separated after 1 term. Results: Analysis revealed disproportionately high rates of mental disorders among Marines not recommended for re-enlistment (Odds Ratio = 8.5, 95% Confidence Interval 7.5-9.8) compared with Marines who re-enlisted. Mental disorder prevalence was also elevated among service members who voluntarily separated after 1 term (Odds Ratio = 1.2, 95% Confidence Interval 1.1-1.3). Several specific categories of disorders, including personality disorders, substance use disorders, and post-traumatic stress disorder, predicted re-enlistment status. Conclusions: These results suggest that mental disorders influence personnel retention in diverse ways, including heightened turnover, which could have a substantial impact on military manpower costs. C1 [Schmied, Emily A.; Highfill-McRoy, Robyn M.; Larson, Gerald E.] Naval Hlth Res Ctr, San Diego, CA 92106 USA. RP Schmied, EA (reprint author), Naval Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. FU Department of the Army Defense Medical Research and Development Program [60209] FX This represents report 11-639, supported by the Department of the Army Defense Medical Research and Development Program, under work unit 60209. The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, the Department of Defense, or the U.S. Government. This research has been conducted in compliance with all applicable federal regulations governing the protection of human subjects in research (Protocol NHRC.2009.0024). Approved for public release; distribution is unlimited. NR 17 TC 3 Z9 3 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUL PY 2012 VL 177 IS 7 BP 766 EP 772 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA V33NZ UT WOS:000209026800002 PM 22808881 ER PT J AU MacGregor, AJ Dougherty, AL Mayo, JA Rauh, MJ Galarneau, MR AF MacGregor, Andrew J. Dougherty, Amber L. Mayo, Jonathan A. Rauh, Mitchell J. Galarneau, Michael R. TI Occupational Correlates of Low Back Pain Among US Marines Following Combat Deployment SO MILITARY MEDICINE LA English DT Article AB Many U.S. Marines have experienced routine combat deployments during Operation Iraqi Freedom, which present numerous occupational hazards that may result in low back pain (LBP). The objective of this retrospective cohort study was to identify new-onset LBP among Marines following initial deployment to Operation Iraqi Freedom. Active duty Marines deployed to Iraq or Kuwait between 2005 and 2008 were identified from deployment records and linked to medical databases (n = 36,680). The outcome of interest was an International Classification of Diseases, 9th Revision, Clinical Modification code indicating LBP (724.2) within 1 year postdeployment. Multivariate logistic regression examined the effect of occupation on LBP. Overall, 4.1% (n = 1,517) of Marines were diagnosed with LBP. After adjusting for covariates, the service/supply (odds ratio 1.33, 95% confidence interval, 1.12-1.59) and electrical/mechanical/craftsworker occupations (odds ratio 1.31, 95% confidence interval, 1.12-1.53) had higher odds of LBP when compared to the administrative/other referent group. Within these groups, the highest LBP prevalence was in the construction (8.6%) and law enforcement (6.2%) subgroups. Although infantry occupations purposefully engage the enemy and often face sustained physical rigors of combat, LBP was most prevalent in noninfantry occupations. Future studies should include detailed exposure histories to elucidate occupation-specific etiologies of LBP in order to guide prevention efforts. C1 [MacGregor, Andrew J.; Dougherty, Amber L.; Mayo, Jonathan A.; Rauh, Mitchell J.; Galarneau, Michael R.] Naval Hlth Res Ctr, San Diego, CA 92106 USA. RP MacGregor, AJ (reprint author), Naval Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. FU U.S. Navy Bureau of Medicine [60808] FX The authors thank Kevin Heltemes for providing statistical assistance with revisions. Additionally, we thank Science Applications International Corporation for its contributions to this work. This work was supported by the U.S. Navy Bureau of Medicine under the Wounded, III and Injured/Psychological Health/Traumatic Brain Injury Program, Work Unit No. 60808. NR 32 TC 5 Z9 5 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUL PY 2012 VL 177 IS 7 BP 845 EP 849 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA V33NZ UT WOS:000209026800014 PM 22808893 ER PT J AU Boyko, E Seelig, A Jacobson, I Hooper, T Smith, B Smith, T Crum-Cianflone, N AF Boyko, E. Seelig, A. Jacobson, I. Hooper, T. Smith, B. Smith, T. Crum-Cianflone, N. CA Millennium Cohort Study TI SLEEP PATTERNS AND TYPE 2 DIABETES: FINDINGS FROM THE MILLENNIUM COHORT STUDY SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 45th Annual Meeting of the Society-for-Epidemiologic-Research (SER) CY JUN 27-30, 2012 CL Minneapolis, MN SP Soc Epidemiol Res (SER) C1 [Boyko, E.; Seelig, A.; Jacobson, I.; Hooper, T.; Smith, B.; Smith, T.; Crum-Cianflone, N.; Millennium Cohort Study] Naval Hlth Res Ctr, TeamDeployment Hlth Res Dept, San Diego, CA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 15 PY 2012 VL 175 SU 11 BP S110 EP S110 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 197ED UT WOS:000322831400433 ER PT J AU Jacobson, I Horton, J LeardMann, C Ryan, M Boyko, E Wells, T Smith, B Smith, T AF Jacobson, I. Horton, J. LeardMann, C. Ryan, M. Boyko, E. Wells, T. Smith, B. Smith, T. CA Millennium Cohort Study Team TI POSTTRAUMATIC STRESS DISORDER AND DEPRESSION AMONG US MILITARY HEALTH CARE PROFESSIONALS DEPLOYED IN SUPPORT OF THE OPERATIONS IN IRAQ AND AFGHANISTAN. SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 45th Annual Meeting of the Society-for-Epidemiologic-Research (SER) CY JUN 27-30, 2012 CL Minneapolis, MN SP Soc Epidemiol Res (SER) C1 [Jacobson, I.; Horton, J.; LeardMann, C.; Ryan, M.; Boyko, E.; Wells, T.; Smith, B.; Smith, T.; Millennium Cohort Study Team] Naval Hlth Res Ctr, Deployment Hlth Res Dept, San Diego, CA USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 15 PY 2012 VL 175 SU 11 BP S118 EP S118 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 197ED UT WOS:000322831400464 ER PT J AU Woolpert, T Brodine, S Lemus, H Waalen, J Blair, P Faix, D AF Woolpert, Tabitha Brodine, Stephanie Lemus, Hector Waalen, Jill Blair, Patrick Faix, Dennis TI Determination of clinical and demographic predictors of laboratory-confirmed influenza with subtype analysis SO BMC INFECTIOUS DISEASES LA English DT Article DE Influenza; Influenzavirus A; Influenzavirus B; Influenza A Virus; H1N1 Subtype; Diagnosis ID A H1N1 VIRUS; CASE-DEFINITION; RESPIRATORY-TRACT; ELDERLY-PEOPLE; DIAGNOSIS; INFECTION; CHILDREN; SURVEILLANCE; SENSITIVITY; COMMUNITY AB Background: Rapid influenza diagnosis is important for early identification of outbreaks, effective management of high-risk contacts, appropriate antiviral use, decreased inappropriate antibiotic use and avoidance of unnecessary laboratory testing. Given the inconsistent performance of many rapid influenza tests, clinical diagnosis remains integral for optimizing influenza management. However, reliable clinical diagnostic methods are not well-established. This study assesses predictors of influenza, and its various subtypes, in a broad population at the point of care, across age groups, then evaluates the performance of clinical case definitions composed of identified predictors. Methods: Respiratory specimens and demographic and clinical data were obtained from 3- to 80-year-old US military family members presenting for care with influenza-like illness (ILI) from November 2007 to April 2008. Molecular and virus isolation techniques were used to detect and subtype influenza viruses. Associations between influenza diagnosis and demographic/clinical parameters were assessed by logistic regression, including influenza type and subtype analyses. The predictive values of multiple combinations of identified clinical predictors (case definitions), and the Centers for Disease Control and Prevention (CDC) ILI case definition, were estimated. Results: Of 789 subjects, 220 (28%) had laboratory-confirmed influenza (51 A(H1), 46 A(H3), 19 A(unsubtypeable), 67 B, 1 AB coinfection), with the proportion of influenza A to B cases highest among 6- to 17-year-olds (p = 0.019). Independent predictors of influenza included fever, cough, acute onset, body aches, and vaccination status among 6- to 49-year-olds, only vaccination among 3- to 5-year-olds, and only fever among 50- to 80-year-olds. Among 6- to 49-year-olds, some clinical case definitions were highly sensitive (100.0%) or specific (98.6%), but none had both parameters over 60%, though many performed better than the CDC ILI case definition (sensitivity 37.7%, 95% confidence interval 33.6-41.9% in total study population). Conclusions: Patterns of influenza predictors differed across age groups, with most predictors identified among 6- to 49-year-olds. No combination of clinical and demographic predictors served as a reliable diagnostic case definition in the population and influenza season studied. A standardized clinical case definition combined with a point-of-care laboratory test may be the optimal rapid diagnostic strategy available. C1 [Woolpert, Tabitha; Blair, Patrick; Faix, Dennis] Naval Hlth Res Ctr, San Diego, CA 92106 USA. [Brodine, Stephanie; Lemus, Hector] San Diego State Univ, San Diego, CA 92182 USA. [Waalen, Jill] UCSD Sch Med, La Jolla, CA 92093 USA. RP Woolpert, T (reprint author), Naval Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. EM tabitha.woolpert@med.navy.mil RI Valle, Ruben/A-7512-2013 FU Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response System (GEIS) operations [60501] FX This work represents reports 11-16 supported by the Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response System (GEIS) operations [work unit number 60501]. The funding body was not involved in study design, data collection, analysis, interpretation of results or manuscript writing. NR 40 TC 15 Z9 15 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD JUN 7 PY 2012 VL 12 AR 129 DI 10.1186/1471-2334-12-129 PG 11 WC Infectious Diseases SC Infectious Diseases GA 980MK UT WOS:000306897200002 PM 22676850 ER PT J AU Khuntirat, B Yoon, IK Krueger, W Chittaganrnpitch, M Supawat, K Blair, P Putnam, SD Gibbons, RV Sawanpanyalert, P Heil, GL Friary, JA Gray, GC AF Khuntirat, B. Yoon, I. -K. Krueger, W. Chittaganrnpitch, M. Supawat, K. Blair, P. Putnam, S. D. Gibbons, R. V. Sawanpanyalert, P. Heil, G. L. Friary, J. A. Gray, G. C. TI Pandemic influenza A (H1N1) virus infections among villagers living in rural Thailand SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Meeting Abstract C1 [Khuntirat, B.; Yoon, I. -K.; Gibbons, R. V.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Krueger, W.; Heil, G. L.; Friary, J. A.; Gray, G. C.] Univ Florida, Coll Publ Hlth & Hlth Profess, Gainesville, FL USA. [Chittaganrnpitch, M.; Supawat, K.; Sawanpanyalert, P.] Thai Natl Inst Hlth, Nonthaburi, Thailand. [Blair, P.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Putnam, S. D.] JMI Labs, N Liberty, IA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD JUN PY 2012 VL 16 SU 1 BP E348 EP E348 DI 10.1016/j.ijid.2012.05.424 PG 1 WC Infectious Diseases SC Infectious Diseases GA 999YX UT WOS:000308353101410 ER PT J AU Zhang, TT Gao, XS Webler, BA Cockeram, BV Hayden, M Graham, SM AF Zhang, Tingting Gao, Xiaosheng Webler, Bryan A. Cockeram, Brian V. Hayden, Matthew Graham, Stephen M. TI APPLICATION OF THE PLASTICITY MODELS THAT INVOLVE THREE STRESS INVARIANTS SO INTERNATIONAL JOURNAL OF APPLIED MECHANICS LA English DT Article DE Yield function; flow potential; stress invariants; pressure sensitivity and Lode dependence; experiments and finite element analysis ID NONASSOCIATED FLOW RULE; HYDROSTATIC-STRESS; METAL PLASTICITY; DEFORMATION-BEHAVIOR; NUMERICAL-SIMULATION; RUPTURE MECHANISMS; DUCTILE FRACTURE; COMBINED TENSION; YIELD CRITERION; PRESSURE AB Increasing experimental evidence shows that the classical J(2) plasticity theory may not fully describe the plastic response of many materials, including some metallic alloys. In this paper, the effect of stress state on plasticity and the general forms of the yield function and flow potential for isotropic materials are assumed to be functions of the first invariant of the stress tensor (I-1) and the second and third invariants of the deviatoric stress tensor (J(2) and J(3)). A 5083 aluminum alloy, Nitronic 40 (a stainless steel), and Zircaloy-4 (a zirconium alloy) were tested under tension, compression, torsion, combined torsion-tension and combined torsion-compression at room temperature to demonstrate the applicability of a proposed I-1-J(2)-J(3) dependent model. The I-1-J(2)-J(3) dependent plasticity model was implemented in ABAQUS via a user defined subroutine. The model parameters were determined and validated by comparing the numerically predicted and experimentally measured load versus displacement and/or torque versus twist angle curves. The results showed that the proposed model incorporating the I-1-J(2)-J(3) dependence produced output that matched experimental data more closely than the classical J(2) plasticity theory for the loading conditions and materials tested. C1 [Zhang, Tingting; Gao, Xiaosheng] Univ Akron, Dept Mech Engn, Akron, OH 44325 USA. [Webler, Bryan A.; Cockeram, Brian V.] Bechtel Marine Prop Corp, W Mifflin, PA 15122 USA. [Hayden, Matthew] Naval Surface Warfare Ctr, Alloy Dev & Mech Branch, Bethesda, MD 20817 USA. [Graham, Stephen M.] USN Acad, Dept Mech Engn, Annapolis, MD 21402 USA. RP Gao, XS (reprint author), Univ Akron, Dept Mech Engn, Akron, OH 44325 USA. EM xgao@uakron.edu FU Office of Naval Research [N00014-09-1-0553] FX This research was partially supported by the Office of Naval Research (N00014-09-1-0553). NR 45 TC 5 Z9 5 U1 0 U2 13 PU IMPERIAL COLLEGE PRESS PI LONDON PA 57 SHELTON ST, COVENT GARDEN, LONDON WC2H 9HE, ENGLAND SN 1758-8251 J9 INT J APPL MECH JI Int. J. Appl. Mech. PD JUN PY 2012 VL 4 IS 2 AR 1250021 DI 10.1142/S1758825112500214 PG 24 WC Mechanics SC Mechanics GA 973OR UT WOS:000306370100010 ER PT J AU Powell, TM Smith, TC Jacobson, IG Boyko, EJ Hooper, TI Gackstetter, GD Phillips, CJ Smith, B AF Powell, Teresa M. Smith, Tyler C. Jacobson, Isabel G. Boyko, Edward J. Hooper, Tomoko I. Gackstetter, Gary D. Phillips, Christopher J. Smith, Besa CA Millennium Cohort Study Team TI Prospective Assessment of Chronic Multisymptom Illness Reporting Possibly Associated with Open-Air Burn Pit Smoke Exposure in Iraq SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID GULF-WAR VETERANS; HEALTH-CARE UTILIZATION; MILLENNIUM COHORT; MENTAL-HEALTH; US MILITARY; HOSPITALIZATION DATA; AFGHANISTAN; SYMPTOMS; PREVALENCE; DEPLOYMENT AB Objective: To investigate the relationship between chronic multisymptom illness (CMI) and possible exposure to an open-air burn pit at three selected bases among those deployed to operations in Iraq and Afghanistan. Methods: Chronic multisymptom illness (reporting at least one symptom in at least two of the following symptom constructs: general fatigue; mood and cognition problems; and musculoskeletal discomfort) was assessed, differentiating by potential burn pit exposure, among deployers who completed 2004 and 2007 Millennium Cohort questionnaires. Results: More than 21,000 Cohort participants were deployed in support of the current operations, including more than 3000 participants with at least one deployment within a 3-mile radius of a documented burn pit. After adjusting for covariates, no elevated risk of CMI was observed among those exposed. Conclusions: There was no increase in CMI symptom reporting in those deployed to three selected bases with documented burn pits compared with other deployers. C1 [Powell, Teresa M.; Smith, Tyler C.; Jacobson, Isabel G.; Phillips, Christopher J.; Smith, Besa] Naval Hlth Res Ctr, Deployment Hlth Res Dept, San Diego, CA 92106 USA. [Boyko, Edward J.] Dept Vet Affairs Puget Sound Hlth Care Syst, Seattle Epidemiol Res & Informat Ctr, Seattle, WA USA. [Hooper, Tomoko I.] USUHS, Dept Prevent Med & Biometr, Bethesda, MD USA. [Gackstetter, Gary D.] Analyt Serv Inc ANSER, Arlington, VA USA. RP Powell, TM (reprint author), Naval Hlth Res Ctr, Deployment Hlth Res Dept 164, 140 Sylvester Rd, San Diego, CA 92106 USA. EM teresa.powell@med.navy.mil FU Department of Defense [60002]; US Army FX This research represents Naval Health Research Center report 11-36, supported by the Department of Defense, under work unit no. 60002. Support for this work was provided by the Military Operational Medicine Research Program (MOMRP), a program of the US Army. VA Puget Sound Health Care System provided the resources to support Dr. Boyko's participation in this research. NR 48 TC 9 Z9 9 U1 1 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD JUN PY 2012 VL 54 IS 6 SI SI BP 682 EP 688 DI 10.1097/JOM.0b013e318255ba39 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 957MA UT WOS:000305165900006 PM 22684320 ER PT J AU Conlin, AMS DeScisciolo, C Sevick, CJ Bukowinski, AT Phillips, CJ Smith, TC AF Conlin, Ava Marie S. DeScisciolo, Connie Sevick, Carter J. Bukowinski, Anna T. Phillips, Christopher J. Smith, Tyler C. TI Birth Outcomes Among Military Personnel After Exposure to Documented Open-Air Burn Pits Before and During Pregnancy SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID DEFECTS SURVEILLANCE; SEMEN QUALITY; POLLUTION; RISK; MALFORMATIONS; FRAMEWORK; ATLANTA; STRESS AB Objective: To examine birth outcomes in military women and men with potential exposure to documented open-air burn pits before and during pregnancy. Methods: Electronic data from the Department of Defense Birth and Infant Health Registry and the Defense Manpower Data Center were used to examine the prevalence of birth defects and prcterm birth among infants of active-duly women and men who were deployed within a 3-mile radius of a documented open-air burn pit before or during pregnancy. Results: In general, burn pit exposure at various times in relation to pregnancy and for differing durations was not consistently associated with an increase in birth defects or preterm birth in infants of active-duty military personnel. Conclusions: These analyses offer reassurance to service members that burn pit exposure is net consistently associated with these select adverse infant health outcomes. C1 [Conlin, Ava Marie S.; DeScisciolo, Connie; Sevick, Carter J.; Bukowinski, Anna T.; Phillips, Christopher J.; Smith, Tyler C.] Naval Hlth Res Ctr, Dept Deployment Hlth Res, San Diego, CA 92106 USA. [Smith, Tyler C.] Natl Univ, Sch Hlth & Human Serv, Dept Community Hlth, La Jolla, CA USA. RP Conlin, AMS (reprint author), Naval Hlth Res Ctr, Dept 164, 140 Sylvester Rd, San Diego, CA 92106 USA. EM Ava.Conlin@med.navy.mil FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland; US Department of Defense [60504] FX The authors thank Scott L. Seggerman, Anna Hernandez, Steve Halko, and Kris Hoffman front the US Defense Manpower Data Center; Monterey, California, for providing demographic and deployment data. We appreciate the support of the Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland.; This work represents report 11-40, supported by the US Department of Defense, under work unit number 60504. NR 35 TC 10 Z9 11 U1 0 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD JUN PY 2012 VL 54 IS 6 SI SI BP 689 EP 697 DI 10.1097/JOM.0b013e31824fe154 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 957MA UT WOS:000305165900007 PM 22517496 ER PT J AU Jones, KA Smith, B Granado, NS Boyko, EJ Gackstetter, GD Ryan, MAK Phillips, CJ Smith, TC AF Jones, Kelly A. Smith, Besa Granado, Nisara S. Boyko, Edward J. Gackstetter, Gary D. Ryan, Margaret A. K. Phillips, Christopher J. Smith, Tyler C. CA Millennium Cohort Study Team TI Newly Reported Lupus and Rheumatoid Arthritis in Relation to Deployment Within Proximity to a Documented Open-Air Burn Pit in Iraq SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID DEFENSE HOSPITALIZATION DATA; GULF-WAR VETERANS; MILLENNIUM COHORT; US MILITARY; AUTOIMMUNE-DISEASES; HEALTH; ERYTHEMATOSUS; EPIDEMIOLOGY; PREVALENCE; EXPOSURES AB Objective: To assess the relationship between possible exposure to smoke from documented open-air burn pits and newly reported lupus and rheumatoid arthritis among Millennium Cohort participants who have deployed in support of operations in Iraq and Afghanistan. Methods: Prospectively assessed self-reported lupus and rheumatoid arthritis among deployers who completed both 2004-2006 and 2007-2008 questionnaires. Results: After exclusions, more than 18,000 participants were deployed, including more than 3000 participants deployed within a 3-mile radius of a documented burn pit. After adjustment, proximity within 3 miles of a burn pit was not significantly associated with rheumatoid arthritis or lupus in general; however, one location was associated with lupus, although few cases were at this site (n = 2). Conclusions: Results indicate deployers potentially exposed to documented burn pits in the combined three-camp analysis were not at an elevated risk of lupus or rheumatoid arthritis. C1 [Jones, Kelly A.; Smith, Besa; Granado, Nisara S.; Phillips, Christopher J.; Smith, Tyler C.] Naval Hlth Res Ctr, Dept Deployment Hlth Res, San Diego, CA 92106 USA. [Boyko, Edward J.] Dept Vet Affairs Puget Sound Hlth Care Syst, Seattle Epidemiol Res & Informat Ctr, Seattle, WA USA. [Gackstetter, Gary D.] Analyt Serv Inc ANSER, Arlington, VA USA. [Ryan, Margaret A. K.] Naval Hosp Camp Pendleton, Dept Occupat Hlth, Camp Pendleton, CA USA. [Smith, Tyler C.] Natl Univ, Sch Hlth & Human Serv, Dept Community Hlth, La Jolla, CA USA. RP Jones, KA (reprint author), Naval Hlth Res Ctr, Deployment Hlth Res Dept 164, 140 Sylvester Rd, San Diego, CA 92106 USA. EM kelly.jones@med.navy.mil FU Department of Defense [60002]; US Army FX This research represents Naval Health Research Center report 11-39, supported by the Department of Defense, under work unit no. 60002. Support for this work was provided by the Military Operational Medicine Research Program (MOMRP), a program of the US Army. VA Puget Sound Health Care System provided support for Dr. Boyko's participation in this research. NR 55 TC 8 Z9 8 U1 1 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD JUN PY 2012 VL 54 IS 6 SI SI BP 698 EP 707 DI 10.1097/JOM.0b013e3182529799 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 957MA UT WOS:000305165900008 PM 22588476 ER PT J AU Smith, B Wong, CA Boyko, EJ Phillips, CJ Gackstetter, GD Ryan, MAK Smith, TC AF Smith, Besa Wong, Charlene A. Boyko, Edward J. Phillips, Christopher J. Gackstetter, Gary D. Ryan, Margaret A. K. Smith, Tyler C. CA Millennium Cohort Study Team TI The Effects of Exposure to Documented Open-Air Burn Pits on Respiratory Health Among Deployers of the Millennium Cohort Study SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID OCCUPATIONAL ASTHMA; POLLUTION EXPOSURE; MILITARY PERSONNEL; POINT SOURCES; AFGHANISTAN; RISK; VALIDATION; MORTALITY; SYMPTOMS; VETERANS AB Objective: To investigate respiratory illnesses and potential open-air burn pit exposure among Millennium Cohort participants who deployed to Iraq or Afghanistan. Methods: Using multivariable logistic regression, newly reported chronic bronchitis or emphysema, newly reported asthma, and self-reported respiratory symptoms and possible burn pit exposure within 2, 3, or 5 miles were examined among Army and Air Force deployers surveyed in 2004 to 2006 and 2007 to 2008 (n = 22,844). Results: Burn pit exposure within 3 or 5 miles was not associated with respiratory outcomes after statistical adjustment. Increased symptom reporting was observed among Air Force deployers located within 2 miles of Joint Base Balad; however, this finding was marginally significant with no evidence of trend. Conclusion: In general, these findings do not support an elevated risk for respiratory outcomes among personnel deployed within proximity of documented burn pits in Iraq. C1 [Smith, Besa; Wong, Charlene A.; Phillips, Christopher J.; Smith, Tyler C.] Naval Hlth Res Ctr, Dept Deployment Hlth Res, San Diego, CA 92106 USA. [Boyko, Edward J.] Dept Vet Affairs Puget Sound Hlth Care Syst, Seattle Epidemiol Res & Informat Ctr, Seattle, WA USA. [Gackstetter, Gary D.] Analyt Serv Inc, Arlington, VA USA. [Ryan, Margaret A. K.] Naval Hosp Camp Pendleton, Dept Occupat Hlth, Camp Pendleton, CA USA. [Smith, Tyler C.] Natl Univ, Sch Hlth & Human Serv, Dept Community Hlth, La Jolla, CA USA. RP Smith, B (reprint author), Naval Hlth Res Ctr, Dept Def Ctr Deployment Hlth Res, 140 Sylvester Rd, San Diego, CA 92106 USA. EM besa.smith@med.navy.mil FU Department of Defense [60002]; US Army FX This research represents Naval Health Research Center report 11-38, supported by the Department of Defense, under work unit no. 60002. Support for this work was provided by the Military Operational Medicine Research Program (MOMRP), a program of the US Army. VA Puget Sound provided support for Dr Boyko's participation in this research. NR 46 TC 19 Z9 19 U1 0 U2 15 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD JUN PY 2012 VL 54 IS 6 SI SI BP 708 EP 716 DI 10.1097/JOM.0b013e31825107f9 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 957MA UT WOS:000305165900009 PM 22684321 ER PT J AU Whitehead, TA Chevalier, A Song, YF Dreyfus, C Fleishman, SJ De Mattos, C Myers, CA Kamisetty, H Blair, P Wilson, IA Baker, D AF Whitehead, Timothy A. Chevalier, Aaron Song, Yifan Dreyfus, Cyrille Fleishman, Sarel J. De Mattos, Cecilia Myers, Chris A. Kamisetty, Hetunandan Blair, Patrick Wilson, Ian A. Baker, David TI Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing SO NATURE BIOTECHNOLOGY LA English DT Article ID YEAST SURFACE DISPLAY; FITNESS LANDSCAPE; PROTEIN-STRUCTURE; SOLVENT MODELS; IN-VITRO; ANTIBODIES; RESOLUTION; MUTAGENESIS; EPITOPE; CELLS AB We show that comprehensive sequence-function maps obtained by deep sequencing can be used to reprogram interaction specificity and to leapfrog over bottlenecks in affinity maturation by combining many individually small contributions not detectable in conventional approaches. We use this approach to optimize two computationally designed inhibitors against H1N1 influenza hemagglutinin and, in both cases, obtain variants with subnanomolar binding affinity. The most potent of these, a 51-residue protein, is broadly cross-reactive against all influenza group 1 hemagglutinins, including human H2, and neutralizes H1N1 viruses with a potency that rivals that of several human monoclonal antibodies, demonstrating that computational design followed by comprehensive energy landscape mapping can generate proteins with potential therapeutic utility. C1 [Whitehead, Timothy A.; Chevalier, Aaron; Song, Yifan; Fleishman, Sarel J.; Kamisetty, Hetunandan; Baker, David] Univ Washington, Dept Biochem, Seattle, WA 98195 USA. [Dreyfus, Cyrille; Wilson, Ian A.] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA. [Dreyfus, Cyrille; Wilson, Ian A.] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA. [De Mattos, Cecilia; Myers, Chris A.; Blair, Patrick] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Baker, David] Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA. RP Baker, D (reprint author), Univ Washington, Dept Biochem, Seattle, WA 98195 USA. EM dabaker@u.washington.edu RI Valle, Ruben/A-7512-2013; Baker, David/K-8941-2012; OI Baker, David/0000-0001-7896-6217; Fleishman, Sarel/0000-0003-3177-7560 FU Defense Advanced Research Projects Agency (DARPA); Defense Threat Reduction Agency (DTRA); US National Institutes of Health, National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences [Y1-GM-1104]; National Cancer Institute [Y1-CO-1020]; US Department of Energy, Basic Energy Sciences, Office of Science [DE-AC02-06CH11357] FX We thank D. Fowler and S. Fields for helpful discussions and use of their in-house software to process sequencing data, C. Lee, J. Shendure and M. Dunham for experimental expertise in DNA prep and sequencing, C. Sitz and C. Santiago for technical help and the Joint Center for Structural Genomics for crystallization using the JCSG/IAVI/TSRI Rigaku Crystalmation system. This work was funded by Defense Advanced Research Projects Agency (DARPA) and the Defense Threat Reduction Agency (DTRA), and US National Institutes of Health, National Institute of Allergy and Infectious Diseases and National Institute of General Medical Sciences. The GM/CA CAT 23-ID-B beamline has been funded in whole or in part with federal funds from National Cancer Institute (Y1-CO-1020) and NIGMS (Y1-GM-1104). Use of the Advanced Photon Source (APS) was supported by the US Department of Energy, Basic Energy Sciences, Office of Science, under contract no. DE-AC02-06CH11357. The content is solely the responsibility of the authors and does not necessarily represent the official views of NIGMS or the NIH. NR 44 TC 120 Z9 120 U1 3 U2 54 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1087-0156 J9 NAT BIOTECHNOL JI Nat. Biotechnol. PD JUN PY 2012 VL 30 IS 6 BP 543 EP + DI 10.1038/nbt.2214 PG 9 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA 957JV UT WOS:000305158600024 PM 22634563 ER PT J AU Hourani, L Bender, R Weimer, B Larson, G AF Hourani, Laurel Bender, Randy Weimer, Belinda Larson, Gerald TI Comparative Analysis of Mandated Versus Voluntary Administrations of Post-Deployment Health Assessments Among Marines SO MILITARY MEDICINE LA English DT Article ID HIGH AGREEMENT; LOW KAPPA; AFGHANISTAN; PARADOXES; VETERANS; SOLDIERS; HISTORY; IRAQ AB Little empirical data exist regarding candidness of service members' responses on the mandated Post-Deployment Health Reassessment (PDHRA) administered 3 to 6 months postdeployment. This study reports on the agreement between responses from U.S. Marines on a subset of the military-administered mandatory PDHRA items and answers to the same subset of items embedded in confidential research surveys. Results show that personnel are clearly underreporting certain symptoms and conditions on the mandatory PDHRA. The most dramatic increases in reporting on the research study's PDHRA items, as indicated by the percentage ratio, were for self-harming ideation and concern about harming others, each of which has about 14 times the endorsement percentage on the survey as on the official PDHRA. Lack of agreement for some items may be the result of resolution or onset of more acute conditions, but disagreement on sensitive behavioral concerns suggests that mandated PDHRAs are not effective screens for those domains. C1 [Hourani, Laurel; Bender, Randy; Weimer, Belinda] RTI Int, Res Triangle Pk, NC 27709 USA. [Larson, Gerald] USN, Hlth Res Ctr, San Diego, CA 92106 USA. RP Hourani, L (reprint author), RTI Int, 3040 Cornwallis Rd, Res Triangle Pk, NC 27709 USA. FU NHRC [W911QY-08-D-0021] FX We thank all Marine participants and TAP leadership involved in the study for their service to the country and their support for this research. This research was supported by the NHRC (contract no. W911QY-08-D-0021). NR 27 TC 7 Z9 7 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 2012 VL 177 IS 6 BP 643 EP 648 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 955QP UT WOS:000305036300005 PM 22730838 ER PT J AU Chan, KS Enright, MP Golden, PJ Naboulsi, S Chandra, R Pentz, AC AF Chan, Kwai S. Enright, Michael P. Golden, Patrick J. Naboulsi, Samir Chandra, Ramesh Pentz, Alan C. TI Probabilistic High-Cycle Fretting Fatigue Assessment of Gas Turbine Engine Components SO JOURNAL OF ENGINEERING FOR GAS TURBINES AND POWER-TRANSACTIONS OF THE ASME LA English DT Article ID METHODOLOGY AB High-cycle fatigue (HCF) is arguably one of the costliest sources of in-service damage in military aircraft engines. HCF of turbine blades and disks can pose a significant engine risk because fatigue failure can result from resonant vibratory stresses sustained over a relatively short time. A common approach to mitigate HCF risk is to avoid dangerous resonant vibration modes (first bending and torsion modes, etc.) and instabilities (flutter and rotating stall) in the operating range. However, it might be impossible to avoid all the resonance for all flight conditions. In this paper, a methodology is presented to assess the influences of HCF loading on the fracture risk of gas turbine engine components subjected to fretting fatigue. The methodology is based on an integration of a global finite element analysis of the disk-blade assembly, numerical solution of the singular integral equations using the CAPRI (Contact Analysis for Profiles of Random Indenters) and Worst Case Fret methods, and risk assessment using the DARWIN (Design Assessment of Reliability with Inspection) probabilistic fracture mechanics code. The methodology is illustrated for an actual military engine disk under real life loading conditions. [DOI: 10.1115/1.4005975] C1 [Chan, Kwai S.; Enright, Michael P.] SW Res Inst, San Antonio, TX 78238 USA. [Golden, Patrick J.] USAF, Res Lab, Wright Patterson AFB, OH 45433 USA. [Naboulsi, Samir] High Performance Technol Inc, Wright Patterson AFB, OH 45433 USA. [Chandra, Ramesh; Pentz, Alan C.] NAVAIR, Patuxent River, MD 20670 USA. RP Chan, KS (reprint author), SW Res Inst, San Antonio, TX 78238 USA. FU NAVAIR [EDO-08-SA-0021]; DoD FX This work was supported by NAVAIR under Agreement EDO-08-SA-0021. The computational FEM analyses are performed using the DoD High Performance Computing Modernization Program (HPCMP) support. The assistance by Dr. Wuwei Liang, Mr. Jonathan Moody, and Ms. Loretta Mesa, all of SwRI, are acknowledged. NR 30 TC 2 Z9 2 U1 1 U2 37 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0742-4795 J9 J ENG GAS TURB POWER JI J. Eng. Gas. Turbines Power-Trans. ASME PD JUN PY 2012 VL 134 IS 6 AR 062502 DI 10.1115/1.4005975 PG 8 WC Engineering, Mechanical SC Engineering GA 931ZF UT WOS:000303257300008 ER PT J AU Freeman, W Karunasiri, G AF Freeman, Will Karunasiri, Gamani TI Nonequilibrium electron leakage in terahertz quantum cascade structures SO PHYSICAL REVIEW B LA English DT Article ID INTERSUBBAND TRANSITIONS; LASERS; SCATTERING; TRANSPORT; WELLS; SEMICONDUCTOR; SIMULATION; INTERFACE; LINEWIDTH; ROUGHNESS AB The nonequilibrium absorption of longitudinal-optical phonons by hot electrons are studied in terahertz quantum cascade structures. We present a method for including electron leakage to the continuum that takes into account the mobility of the electrons. This is incorporated into a density matrix Monte Carlo method that includes the optical field within the resonant cavity. The effects of electron leakage to the continuum as a function of lattice temperature are discussed. Results are compared with experiment and found to be consistent. It is shown that using only confined wave functions and thereby neglecting the leakage via tunneling is inadequate for describing the electron transport. C1 [Freeman, Will] USN, Div Phys, Air Warfare Ctr, China Lake, CA 93555 USA. [Karunasiri, Gamani] USN, Dept Phys, Postgrad Sch, Monterey, CA 93943 USA. RP Freeman, W (reprint author), USN, Div Phys, Air Warfare Ctr, China Lake, CA 93555 USA. EM will.freeman@navy.mil FU ONR through the ILIR; ONR FX This work is in part supported by ONR through the ILIR Program. One of us (GK) would also like to acknowledge the support from an ONR grant. NR 57 TC 5 Z9 5 U1 0 U2 4 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD MAY 29 PY 2012 VL 85 IS 19 AR 195326 DI 10.1103/PhysRevB.85.195326 PG 6 WC Physics, Condensed Matter SC Physics GA 948TS UT WOS:000304526100008 ER PT J AU Perepezko, JH Bero, JM Sakidja, R Talmy, IG Zaykoski, J AF Perepezko, J. H. Bero, J. M. Sakidja, R. Talmy, I. G. Zaykoski, J. TI Oxidation resistant coatings for refractory metal cermets SO SURFACE & COATINGS TECHNOLOGY LA English DT Article DE Cermet; Oxidation; Aluminoborosilicate coating; Pack cementation ID ZRC-MO CERMETS; HIGH-TEMPERATURE; MECHANICAL-PROPERTIES; ALLOYS; MICROSTRUCTURE; COMPOSITES; MOLYBDENUM; ZIRCONIA; TUNGSTEN; HAFNIUM AB Refractory metal cermets have attractive mechanical properties for high temperature applications, but exhibit poor resistance to oxidation attack. A two-step coating process has been developed in order to provide an effective high temperature oxidation resistance. W-HfN and Mo-ZrN cermet samples were initially coated with a layer of Mo through a Mo(CO)(6) decomposition reaction. The second step involved a co-deposition of B and Si by a pack cementation treatment. The resultant aluminoborosilicate coating exhibits good adherence to the cermet samples. Oxidation exposure at temperatures up to 1400 degrees C demonstrated minimal mass change and an unaltered cermet microstructure. (c) 2012 Elsevier B.V. All rights reserved. C1 [Perepezko, J. H.; Sakidja, R.] Univ Wisconsin Madison, Dept Mat Sci & Engn, Madison, WI 53706 USA. [Bero, J. M.] Caterpillar Inc, Peoria, IL 61629 USA. [Talmy, I. G.; Zaykoski, J.] Naval Surface Warfare Ctr, Carderock Div, Bethesda, MD 20817 USA. RP Sakidja, R (reprint author), Univ Wisconsin Madison, Dept Mat Sci & Engn, 1509 Univ Ave, Madison, WI 53706 USA. EM sakidja@cae.wisc.edu FU ONR at the University of Wisconsin-Madison [N00014-08-1-1208, N00014-10-1-0913] FX The support of ONR (N00014-08-1-1208 and N00014-10-1-0913) at the University of Wisconsin-Madison is most gratefully acknowledged. NR 31 TC 9 Z9 9 U1 2 U2 33 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0257-8972 J9 SURF COAT TECH JI Surf. Coat. Technol. PD MAY 25 PY 2012 VL 206 IS 19-20 BP 3816 EP 3822 DI 10.1016/j.surfcoat.2012.01.026 PG 7 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA 963ZB UT WOS:000305662400002 ER PT J AU Crum-Cianflone, NF Roediger, MP Moore, DJ Hale, B Weintrob, A Ganesan, A Eberly, LE Johnson, E Agan, BK Letendre, S AF Crum-Cianflone, Nancy F. Roediger, Mollie Poehlman Moore, David J. Hale, Braden Weintrob, Amy Ganesan, Anuradha Eberly, Lynn E. Johnson, Erica Agan, Brian K. Letendre, Scott TI Prevalence and Factors Associated With Sleep Disturbances Among Early-Treated HIV-Infected Persons SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID INSOMNIA; EFAVIRENZ; QUALITY; DISORDERS; MANAGEMENT; ETRAVIRINE; THERAPY; ADULTS; MEN AB Background. Sleep disturbances are reportedly common among persons infected with human immunodeficiency virus (HIV), but recent data, including comparisons with HIV-uninfected persons, are limited. Methods. We performed a cross-sectional study among early-treated HIV-infected military beneficiaries (n = 193) to determine the prevalence and factors associated with insomnia (Pittsburgh Sleep Quality Index [PSQI]) and daytime sleepiness (Epworth Sleepiness Scale [ESS]). Data were compared with HIV-uninfected persons (n = 50) matched by age, sex, race or ethnicity, and military rank. Results. Forty-six percent of HIV-infected persons had insomnia (PSQI >5), and 30% reported daytime drowsiness (ESS >= 10). The prevalence of insomnia and daytime sleepiness was not significantly higher compared with the HIV-uninfected group (38% [P = .30] and 20% [P = .18], respectively). In the multivariate model, factors associated with insomnia among HIV infected patients included depression (odds ratio [OR], 16.8; 95% confidence interval [CI], 2.0-142.1; P = .01), increased waist size (OR, 2.7; 95% CI, 1.4-5.1; P = .002), and fewer years of education (OR, 0.8; 95% CI, .7-.95; P = .006). Neurocognitive impairment (diagnosed in 19% of HIV-infected participants) was not associated with insomnia; however, HIV-infected persons with insomnia were 3.1-fold more likely to have a decline in activities of daily living than those without insomnia (23% vs 9%; P = .01). Only 18% of HIV-infected persons reported using a sleep medication at least weekly. Conclusions. HIV-infected persons have a high prevalence of insomnia, but among an early-treated cohort this rate was not significantly higher compared with HIV-uninfected persons. Factors associated with insomnia among HIV-infected patients include depression and increased waist size. Prompt diagnosis and treatment of sleep disturbances are advocated and may improve quality of life. C1 [Crum-Cianflone, Nancy F.] Naval Med Ctr San Diego, Clin Invest Dept KCA, Div Infect Dis, HIV Clin, San Diego, CA 92134 USA. [Crum-Cianflone, Nancy F.; Roediger, Mollie Poehlman; Hale, Braden; Weintrob, Amy; Ganesan, Anuradha; Eberly, Lynn E.; Johnson, Erica; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Infect Dis Clin, Bethesda, MD USA. [Crum-Cianflone, Nancy F.; Hale, Braden] Naval Hlth Res Ctr, San Diego, CA USA. [Moore, David J.; Letendre, Scott] Univ Calif San Diego, HIV Neurobehav Res Program, San Diego, CA 92103 USA. [Roediger, Mollie Poehlman; Eberly, Lynn E.] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Weintrob, Amy] Walter Reed Army Med Ctr, Infect Dis Clin, Washington, DC USA. [Johnson, Erica] San Antonio Mil Med Ctr, Infect Dis Serv, San Antonio, TX USA. RP Crum-Cianflone, NF (reprint author), Naval Med Ctr San Diego, Clin Invest Dept KCA, Div Infect Dis, HIV Clin, 34800 Bob Wilson Dr,Ste 5, San Diego, CA 92134 USA. EM nancy.crum@med.navy.mil OI Eberly, Lynn/0000-0003-4763-330X; Agan, Brian/0000-0002-5114-1669 FU Department of Defense through Uniformed Services University of the Health Sciences [HU0001-05-2-0011]; National Institute of Allergy and Infectious Diseases, National Institutes of Health [Y1-AI-5072]; National Institute of Mental Health [P30 MH62512] FX This work was supported by the Infectious Disease Clinical Research Program, a Department of Defense program executed through the Uniformed Services University of the Health Sciences (grant number HU0001-05-2-0011). This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, under Inter-Agency Agreement Y1-AI-5072. Support was also obtained from the National Institute of Mental Health (grant P30 MH62512 to UCSD HIV Neurobehavioral Research Center). NR 37 TC 13 Z9 13 U1 0 U2 7 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD MAY 15 PY 2012 VL 54 IS 10 BP 1485 EP 1494 DI 10.1093/cid/cis192 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 942MW UT WOS:000304049300022 PM 22431801 ER PT J AU Feng, SM AF Feng, Simin TI Loss-Induced Omnidirectional Bending to the Normal in epsilon-Near-Zero Metamaterials SO PHYSICAL REVIEW LETTERS LA English DT Article ID REFRACTION; RADIATION; INDEX AB Contrary to conventional wisdom that light bends away from the normal when it passes from high to low refractive index media, here we demonstrate an exotic phenomenon that the direction of electromagnetic power can bend toward the normal when light is incident from an arbitrary high refractive index medium (or air) to a epsilon-near-zero (ENZ) metamaterial. Moreover, the direction of the transmission is close to the normal for all angles of incidence. This anti-Snell's law refraction results from the interplay between ENZ and material loss. The loss can increase the transmission at the air-ENZ interface and collimate the beam inside the ENZ medium. Furthermore, in an ideal loss configuration, the propagation loss in anisotropic ENZ materials can approach zero when the material loss goes to infinity. C1 USN, Air Warfare Ctr, Michelson Lab, Div Phys, China Lake, CA 93555 USA. RP Feng, SM (reprint author), USN, Air Warfare Ctr, Michelson Lab, Div Phys, China Lake, CA 93555 USA. EM simin.feng@navy.mil FU ONR's N-STAR; NAVAIR's ILIR FX The author gratefully thanks the referees for their valuable suggestions and insightful comments. This work is sponsored by ONR's N-STAR and NAVAIR's ILIR programs. NR 16 TC 54 Z9 56 U1 4 U2 36 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD MAY 10 PY 2012 VL 108 IS 19 AR 193904 DI 10.1103/PhysRevLett.108.193904 PG 5 WC Physics, Multidisciplinary SC Physics GA 939YU UT WOS:000303857800006 PM 23003042 ER PT J AU Louis, ES Kelly, KR Haus, JM Fealy, CE Scelsi, AR Pagadala, MR Kirwan, JP AF Louis, Emily S. Kelly, Karen R. Haus, Jacob M. Fealy, Ciaran E. Scelsi, Amanda R. Pagadala, Mangesh R. Kirwan, John P. TI Short-Term Aerobic Exercise Training Beneficially Alters PYY and GLP-1 in Impaired Glucose Tolerant Individuals SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Louis, Emily S.; Fealy, Ciaran E.; Scelsi, Amanda R.; Pagadala, Mangesh R.; Kirwan, John P.] Cleveland Clin, Cleveland, OH 44106 USA. [Kelly, Karen R.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Haus, Jacob M.] Univ Illinois, Chicago, IL USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 591 EP 591 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363303322 ER PT J AU Macera, CA Aralis, HJ Rauh, MJ MacGregor, AJ AF Macera, Caroline A. Aralis, Hilary J. Rauh, Mitchell J. MacGregor, Andrew J. TI Do Sleep Problems Mediate Development of Mental Health Symptoms After Deployment? SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Macera, Caroline A.; Aralis, Hilary J.; Rauh, Mitchell J.; MacGregor, Andrew J.] Naval Hlth Res Ctr, San Diego, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 697 EP 697 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363303692 ER PT J AU Palombo, LJ AF Palombo, Laura J. TI Severe Drop in Body Core Temperature Following Four Cold Water Immersions SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Palombo, Laura J.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 740 EP 740 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363304044 ER PT J AU Buono, MJ Green, M Jones, D Heaney, JH AF Buono, Michael J. Green, Mia Jones, Doug Heaney, Jay H. TI Increases in Heart Rate and RPE Are Additive During Prolonged Exercise in Heat and Hypoxia SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Buono, Michael J.; Green, Mia; Jones, Doug] San Diego State Univ, San Diego, CA 92182 USA. [Heaney, Jay H.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. NR 0 TC 2 Z9 2 U1 1 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 759 EP 760 PG 2 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363304108 ER PT J AU Jones, DM Green, MS Heaney, JH Buono, MJ AF Jones, Douglas M. Green, Mia S. Heaney, Jay H. Buono, Michael J. TI Heat and Hypoxia Cause Additive Increases in Heat Shock Protein 72 During Submaximal Exercise SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Jones, Douglas M.; Heaney, Jay H.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Green, Mia S.; Buono, Michael J.] San Diego State Univ, San Diego, CA 92182 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 759 EP 759 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363304107 ER PT J AU Rodriguez-Soto, AE Jensen, A Jaworski, R Kelly, K Frank, L Ward, SR AF Rodriguez-Soto, Ana E. Jensen, Andrew Jaworski, Rebecca Kelly, Karen Frank, Lawrence Ward, Samuel R. TI Lumbar Spine Kinematics in Marine Corps Soldiers Carrying Heavy Loads SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Rodriguez-Soto, Ana E.; Frank, Lawrence; Ward, Samuel R.] Univ Calif San Diego, La Jolla, CA 92093 USA. [Jensen, Andrew] San Diego State Univ, San Diego, CA 92182 USA. [Jaworski, Rebecca; Kelly, Karen] USN, Hlth Res Ctr, San Diego, CA 92152 USA. NR 0 TC 0 Z9 0 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 775 EP 775 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363304163 ER PT J AU Rauh, MJ Aralis, HJ Macera, CA Bartlett, J MacGregor, AJ Han, PP Galarneau, MR AF Rauh, Mitchell J. Aralis, Hilary J. Macera, Caroline A. Bartlett, Jamie MacGregor, Andrew J. Han, Peggy P. Galarneau, Michael R. TI Gender Comparisons of Sports/Recreation- and Training-Related Injuries Among US Service Members in Operation Iraqi Freedom SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Rauh, Mitchell J.; Aralis, Hilary J.; Macera, Caroline A.; Bartlett, Jamie; MacGregor, Andrew J.; Han, Peggy P.; Galarneau, Michael R.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. RI Bartlett, Jamie/B-9756-2014 OI Bartlett, Jamie/0000-0001-7934-7119 NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 841 EP 841 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363304382 ER PT J AU Keiser, PB Broderick, M AF Keiser, Paul B. Broderick, Michael TI Meningococcal polysaccharide vaccine failure in a patient with C7 deficiency and a decreased anti-capsular antibody response SO HUMAN VACCINES & IMMUNOTHERAPEUTICS LA English DT Article DE complement deficiency; C7; meningococcus; Neisseria; vaccine; military ID LATE COMPLEMENT COMPONENT; MANNOSE-BINDING LECTIN; NEISSERIA-MENINGITIDIS; PROPERDIN DEFICIENCY; FAMILIAL DEFICIENCY; INFECTIOUS-DISEASES; FACTOR-H; ASSOCIATION; HEREDITARY; BACTEREMIA AB A 20-year-old male presented with symptoms of meningococcal sepsis and died despite appropriate medical interventions. Blood cultures grew N. meningitidis serogroup Y. The patient had received the meningococcal quadrivalent (A,C,W-135,Y) polysaccharide vaccine 15 months previously. Because the patient had a history of meningococcal meningitis at age 10, archived serum was obtained for further analysis. Complement component C7 was found to be deficient and antibody levels to meningococcal polysaccharides were undetectable for two serogroups and low for the infecting serogroup 10 months post-vaccination. This case highlights the fact that some individuals with terminal complement component deficiencies mount an impaired or short-lived response to vaccination with meningococcal capsular polysaccharides and underscores the appropriateness of a more aggressive vaccination strategy in this patient population. C1 [Keiser, Paul B.] Walter Reed Natl Mil Med Ctr, Dept Allergy Immunol Immunizat, Bethesda, MD USA. [Broderick, Michael] USN, Hlth Res Ctr, Henry M Jackson Fdn, Dept Resp Dis, San Diego, CA 92152 USA. RP Keiser, PB (reprint author), Walter Reed Natl Mil Med Ctr, Dept Allergy Immunol Immunizat, Bethesda, MD USA. EM paul.keiser@us.army.mil RI Valle, Ruben/A-7512-2013 FU Walter Reed Army Medical Center FX Tests of archived sera were funded by the Walter Reed Army Medical Center and made possible by the staff of the Armed Forces Health Surveillance Center. The views expressed in this work are those of the authors and do not reflect the official policy of the Department of the Navy, Department of the Army, Department of Defense, or the US Government. Approved for public release; distribution is unlimited. This research has been conducted in compliance with all applicable federal regulations governing the protection of human subjects in research. NR 44 TC 6 Z9 6 U1 0 U2 0 PU LANDES BIOSCIENCE PI AUSTIN PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA SN 2164-5515 J9 HUM VACC IMMUNOTHER JI Human Vaccines Immunother. PD MAY PY 2012 VL 8 IS 5 BP 582 EP 586 DI 10.4161/hv.19517 PG 5 WC Biotechnology & Applied Microbiology; Immunology SC Biotechnology & Applied Microbiology; Immunology GA 983FD UT WOS:000307103200015 PM 22634438 ER PT J AU Baker, DG Nash, WP Litz, BT Geyer, MA Risbrough, VB Nievergelt, CM O'Connor, DT Larson, GE Schork, NJ Vasterling, JJ Hammer, PS Webb-Murphy, JA AF Baker, Dewleen G. Nash, William P. Litz, Brett T. Geyer, Mark A. Risbrough, Victoria B. Nievergelt, Caroline M. O'Connor, Daniel T. Larson, Gerald E. Schork, Nicholas J. Vasterling, Jennifer J. Hammer, Paul S. Webb-Murphy, Jennifer A. CA MRS Team TI Predictors of Risk and Resilience for Posttraumatic Stress Disorder Among Ground Combat Marines: Methods of the Marine Resiliency Study SO PREVENTING CHRONIC DISEASE LA English DT Article ID TRAUMATIC BRAIN-INJURY; US MILITARY COHORT; MENTAL-HEALTH; PTSD; IRAQ; DEPLOYMENT; WAR; AFGHANISTAN; DIAGNOSES; SYMPTOMS AB The Marine Resiliency Study (MRS) is a prospective study of factors predictive of posttraumatic stress disorder (PTSD) among approximately 2,600 Marines in 4 battalions deployed to Iraq or Afghanistan. We describe the MRS design and predeployment participant characteristics. Starting in 2008, our research team conducted structured clinical interviews on Marine bases and collected data 4 times: at predeployment and at 1 week, 3 months, and 6 months postdeployment. Integrated with these data are medical and career histories from the Career History Archival Medical and Personnel System (CHAMPS) database. The CHAMPS database showed that 7.4% of the Marines enrolled in MRS had at least 1 mental health diagnosis. Of enrolled Marines, approximately half (51.3%) had prior deployments. We found a moderate positive relationship between deployment history and PTSD prevalence in these baseline data. C1 [Baker, Dewleen G.; Nash, William P.; Nievergelt, Caroline M.] Univ Calif San Diego, La Jolla, CA 92093 USA. [Litz, Brett T.; Vasterling, Jennifer J.] Vet Affairs Boston Healthcare Syst, Boston, MA USA. [Geyer, Mark A.; Risbrough, Victoria B.; O'Connor, Daniel T.] Univ Calif San Diego, San Diego, CA 92103 USA. [Larson, Gerald E.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Schork, Nicholas J.] Scripps Translat Sci Inst, La Jolla, CA USA. [Hammer, Paul S.] Def Ctr Excellence Stress & Mental Hlth Traumat B, Arlington, VA USA. [Webb-Murphy, Jennifer A.] USN, Ctr Combat & Operat Stress Control, San Diego, CA 92152 USA. RP Baker, DG (reprint author), VA San Diego Healthcare Syst, VA Ctr Stress & Mental Hlth 116A, 3350 La Jolla Village Dr, La Jolla, CA 92161 USA. EM dgbaker@ucsd.edu OI Nievergelt, Caroline/0000-0001-5766-8923 FU VA Health Service Research and Development [SDR 09-0128]; Marine Corps and Navy Bureau of Medicine and Surgery FX This study was funded by VA Health Service Research and Development project no. SDR 09-0128 and by the Marine Corps and Navy Bureau of Medicine and Surgery. We acknowledge special assistance from members of VA Center of Excellence for Stress and Mental Health, VA San Diego Research and Fiscal Services, and the 1st Marine Division and Navy Medicine at 29 Palms and at Camp Pendleton. Acknowledged also are core MRS team members Amela Ahmetovic, Nilima Biswas, William H. Black, Mahalah R. Buell, Teresa Carper, Andrew De La Rosa, Benjamin Dickstein, Heather Ellis-Johnson, Caitlin Fernandes, Susan Fesperman, David Fink, Summer Fitzgerald, Steven Gerard, Abigail A. Goldsmith, Gali Goldwaser, Patricia Gorman, Jorge A. Gutierrez, John A. Hall, Jr, Laura Harder, Pia Heppner, Alexandra Kelada, Jennifer Lemmer, Morgan LeSuer-Mandernack, Manjula Mahata, Arame Motazedi, Elin Olsson, Ines Pandzic, Anjana H. Patel, Dhaval H. Patel, Sejal Patel, Shetal M. Patel, Taylor Perin-Kash, James O.E. Pittman, Stephanie Raducha, Brenda Thomas, Elisa Tsan, Maria Anna Valencerina, Chelsea Wallace, Kate Yurgil, Kuixing Zhang, and the many intermittent on-site MRS clinician-interviewers and data collection staff. NR 25 TC 8 Z9 8 U1 3 U2 22 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD MAY PY 2012 VL 9 AR 110134 DI 10.5888/pcd9.110134 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 977HU UT WOS:000306648100005 ER PT J AU Conlin, AS Gumbs, GR Sevick, CJ Snell, KJ Descisciolo, C Bukowinski, AT Lee, S Jacobson, IG Crum-Cianflone, NF AF Conlin, A. S. Gumbs, G. R. Sevick, C. J. Snell, K. J. Descisciolo, C. Bukowinski, A. T. Lee, S. Jacobson, I. G. Crum-Cianflone, N. F. TI The Don Birth and Infant Health Registry: Findings from the First Million Infants SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Meeting Abstract C1 [Conlin, A. S.; Gumbs, G. R.; Sevick, C. J.; Snell, K. J.; Descisciolo, C.; Bukowinski, A. T.; Lee, S.; Jacobson, I. G.; Crum-Cianflone, N. F.] USN, Hlth Res Ctr, Deployment Hlth Res Dept, San Diego, CA 92152 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD MAY PY 2012 VL 94 IS 5 SI SI BP 367 EP 367 PG 1 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA 956FF UT WOS:000305074800143 ER PT J AU Costanzo, A Taylor, K Han, P Fujioka, K Jameson, J AF Costanzo, Anne Taylor, Kristen Han, Peggy Fujioka, Ken Jameson, Julie TI Altered human gamma delta peripheral blood lymphocyte homeostasis and impaired influenza A viral response in obesity SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract CT 99th Annual Meeting of the American-Association-of-Immunologists CY MAY 04-08, 2012 CL Boston, MA SP Amer Assoc Immunol C1 [Costanzo, Anne; Taylor, Kristen; Jameson, Julie] Scripps Res Inst, La Jolla, CA 92037 USA. [Han, Peggy] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Fujioka, Ken] Scripps Clin, Ctr Weight Management, Del Mar, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD MAY 1 PY 2012 VL 188 PG 1 WC Immunology SC Immunology GA 950OX UT WOS:000304659701666 ER PT J AU Granado, NS Zimmermann, L Smith, B Jones, KA Wells, TS Ryan, MAK Slymen, D Koffman, RL Smith, TC AF Granado, Nisara S. Zimmermann, Lauren Smith, Besa Jones, Kelly A. Wells, Timothy S. Ryan, Margaret A. K. Slymen, Donald Koffman, Robert L. Smith, Tyler C. CA Millennium Cohort Study Team TI Individual Augmentee Deployment and Newly Reported Mental Health Morbidity SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID POSTTRAUMATIC-STRESS; MILLENNIUM COHORT; MILITARY SERVICE; COMBAT EXPOSURE; SOCIAL SUPPORT; PRIMARY-CARE; US MILITARY; IRAQ; AFGHANISTAN; DEPRESSION AB Objective: To investigate the association between US Navy individual augmentee (IA) deployers, who may lack the protective effects of unit cohesion and social support, and newly reported mental health. Methods: Responses from the Millennium Cohort Study questionnaires were examined for 2086 Navy deployers in this prospective exploratory study. Multivariable logistic regression was used to evaluate IA deployment and newly reported mental health symptoms. Results: After adjusting for covariates, IA deployment was not significantly associated with newly reported posttraumatic stress disorder (odds ratio = 1.02; 95% confidence interval: 0.53-1.95) or mental health symptoms (odds ratio = 1.03; 95% confidence interval: 0.66-1.60) compared with non-IA deployment. Conclusion: IA deployment was not associated with increased risk for posttraumatic stress disorder or mental health symptoms following deployment. It is likely that social isolation was not highly influential among Navy IAs in this study. C1 [Granado, Nisara S.; Zimmermann, Lauren; Smith, Besa; Jones, Kelly A.; Wells, Timothy S.; Smith, Tyler C.] USN, Deployment Hlth Res Dept, Hlth Res Ctr, San Diego, CA 92106 USA. [Zimmermann, Lauren; Slymen, Donald] San Diego State Univ, Grad Sch Publ Hlth, San Diego, CA 92182 USA. [Ryan, Margaret A. K.] USN, Dept Occupat Hlth, Hosp Camp Pendleton, Camp Pendleton, CA USA. [Koffman, Robert L.] USN, Bur Med & Surg, Washington, DC USA. [Koffman, Robert L.] Natl Intrepid Ctr Excellence, Bethesda, MD USA. RP Granado, NS (reprint author), USN, Dept Def, Ctr Deployment Hlth Res, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. EM nisara.granado@med.navy.mil FU Department of Defense [60002] FX This study represents report 08-18 supported by the Department of Defense, under work unit no. 60002. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of Defense, or the US Government. Approved for public release; distribution is unlimited. This research was conducted in compliance with all applicable federal regulations governing the protection of human subjects (protocol NHRC. 2000.0007). NR 20 TC 4 Z9 4 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD MAY PY 2012 VL 54 IS 5 BP 615 EP 620 DI 10.1097/JOM.0b013e31824be417 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 940UR UT WOS:000303919100017 PM 22547123 ER PT J AU Jacobson, IG Horton, JL Smith, B Wells, TS Boyko, EJ Lieberman, HR Ryan, MAK Smith, TC AF Jacobson, Isabel G. Horton, Jaime L. Smith, Besa Wells, Timothy S. Boyko, Edward J. Lieberman, Harris R. Ryan, Margaret A. K. Smith, Tyler C. CA Millennium Cohort Study Team TI Bodybuilding, Energy, and Weight-Loss Supplements Are Associated With Deployment and Physical Activity in U.S. Military Personnel SO ANNALS OF EPIDEMIOLOGY LA English DT Article DE Dietary Supplements; Exercise; Military Personnel ID MILLENNIUM COHORT; DIETARY-SUPPLEMENTS; COGNITIVE PERFORMANCE; DRINK CONSUMPTION; MAJOR DEPRESSION; MENTAL-DISORDERS; COLLEGE-STUDENTS; NATIONAL-SURVEY; SLEEP DURATION; UNITED-STATES AB PURPOSE: The characteristics of U.S. military personnel who use dietary supplements have not been well described. This study aimed to determine whether deployment experience and physical activity were associated with the use of bodybuilding, energy, or weight-loss supplement among U.S. military personnel. METHODS: Self-reported data from active-duty, Reserve, and National Guard participants of the Millennium Cohort Study collected from 2007-2008 (n = 106,698) on supplement use, physical activity, and other behavioral data were linked with deployment and demographic data. We used multivariable logistic regression sex-stratified models to compare the adjusted odds of each type of supplement use among those with deployment experience in support of operations in Iraq or Afghanistan and those engaged in aerobic or strength-training activities. RESULTS: Overall, 46.7% of participants reported using at least one type of supplement, and 22.0% reported using multiple supplements. Male deployers were more likely to use bodybuilding supplements, whereas female deployers were more likely to use weight-loss supplements. Physically active and younger subjects reported all types of supplement use. Men and women reporting 5 or less hours of sleep per night were more likely to use energy supplements. CONCLUSIONS: The high prevalence of supplement use and important characteristics found to be associated with their use, including deployment, physical activity, and suboptimal sleep, suggest focus areas for future research and adverse event monitoring. Ann Epidemiol 2012;22:318-330. (C) 2012 Elsevier Inc. All rights reserved. C1 [Jacobson, Isabel G.; Horton, Jaime L.; Smith, Besa; Smith, Tyler C.] USN, Hlth Res Ctr, Deployment Hlth Res Dept, San Diego, CA 92106 USA. [Wells, Timothy S.] Res Lab, Wright Patterson AFB, OH USA. [Boyko, Edward J.] Dept Vet Affairs Puget Sound Hlth Care Syst, Seattle Epidemiol Res & Informat Ctr, Seattle, WA USA. [Lieberman, Harris R.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Ryan, Margaret A. K.] USN, Hosp Camp Pendleton, Camp Pendleton, CA USA. RP Jacobson, IG (reprint author), USN, Hlth Res Ctr, Deployment Hlth Res Dept, San Diego, CA 92106 USA. EM isabel.jacobson@med.navy.mil FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, MD; U.S. Army Medical Research and Materiel Command, Fort Detrick, MD; VA Puget Sound Health Care System; Department of Defense [60002] FX The authors thank Paul Amoroso, MD, MPH, from the Madigan Army Medical Center, Tacoma, WA; Gary Gackstetter, DVM, MPH, PhD, from Analytic Services, Inc., Arlington, VA; Tomoko Hooper, MD, MPH, from Uniformed Services University of the Health Sciences, Bethesda, MD. In addition, they thank Melissa Bagnell, MPH, Gina Creaven, MBA, Nancy Crum-Cianflone, MD, MPH, James Davies, Nisara Granado, MPH, PhD, Dennis Hernando, Kelly Jones, MPH, Cynthia LeardMann, MPH, William Lee, Travis Leleu, Gordon Lynch, Hope McMaster, MA, PhD, Amanda Pietrucha, MPH, Teresa Powell, MS, Amber Seelig, MPH, Beverly Sheppard, Katherine Snell, Steven Speigle, Kari Sausedo, MA, Martin White, MPH, James Whitmer, and Charlene Wong, MPH, from the Deployment Health Research Department, Naval Health Research Center, San Diego, CA. They thank Scott L. Seggerman from the Management Information Division, Defense Manpower Data Center, Monterey, CA and also thank Michelle LeWark from the Naval Health Research Center. Finally, they thank the professionals from the U.S. Army Medical Research and Materiel Command, especially those from the Military Operational Medicine Research Program, Fort Detrick, MD. The support of the Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, MD is appreciated. The Millennium Cohort Study is funded through the Military Operational Medicine Research Program of the U.S. Army Medical Research and Materiel Command, Fort Detrick, MD. The funding organization had no role in the design and conduct of the study; collection, analysis, or preparation of data; or preparation, review, or approval of the manuscript. Resources from the VA Puget Sound Health Care System supported Dr. Boyko's involvement in this research. This represents report 11-07, supported by the Department of Defense, under work unit no. 60002. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of the Army, Department of the Air Force, Department of Defense, Department of Veterans Affairs, or the U.S. Government. Approved for public release; distribution is unlimited. This research has been conducted in compliance with all applicable federal regulations governing protection of human subjects in research (Protocol NHRC.2000.0007). NR 61 TC 27 Z9 27 U1 0 U2 8 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1047-2797 J9 ANN EPIDEMIOL JI Ann. Epidemiol. PD MAY PY 2012 VL 22 IS 5 BP 318 EP 330 DI 10.1016/j.annepidem.2012.02.017 PG 13 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 939CF UT WOS:000303783900003 PM 22445519 ER PT J AU Hermes, EDA Wells, TS Smith, B Boyko, EJ Gackstetter, GG Miller, SC Smith, TC AF Hermes, Eric D. A. Wells, Timothy S. Smith, Besa Boyko, Edward J. Gackstetter, Gary G. Miller, Shannon C. Smith, Tyler C. CA Millennium Cohort Study Team TI Smokeless tobacco use related to military deployment, cigarettes and mental health symptoms in a large, prospective cohort study among US service members SO ADDICTION LA English DT Article DE Afghanistan; Iraq war; military personnel; post-traumatic stress disorder; risk factors; smokeless tobacco; tobacco use disorder; veterans; war ID READJUSTMENT RATING-SCALE; MILLENNIUM COHORT; UNITED-STATES; PRIMARY-CARE; FOLLOW-UP; PERSONNEL; SMOKING; PREVALENCE; VALIDATION; STRESS AB Aims To characterize smokeless tobacco initiation and persistence in relation to deployment, combat, occupation, smoking and mental health symptoms. Design Prospective cohort, utilizing self-reported survey data from the Millennium Cohort Study. Setting US military service members in all branches including active duty, reserve and National Guard. Participants Population-based sample of 45 272 participants completing both baseline (July 2001June 2003; n = 77 047) and follow-up (June 2004-January 2006; n = 55 021) questionnaires (follow-up response rate = 71.4%). Measurements Self-reported smokeless tobacco initiation and persistence. Findings Over the study period, 72.4% did not deploy, 13.7% deployed without combat exposures and 13.9% deployed with combat exposures, while 1.9% were smokeless tobacco initiators and 8.9% were persistent users. The odds of initiation were greater for deployers with combat exposure [odds ratio (OR), 1.76; 95% confidence interval (CI), 1.49-2.09], deployers without combat exposure (OR, 1.31; 95% CI, 1.07-1.60) and those who deployed multiple times (OR, 1.67; 95% CI, 1.31-2.14), as well as in smoking recidivists/ initiators (OR, 4.65; 95% CI, 3.82-5.66) and those reporting posttraumatic stress disorder symptoms (OR, 1.54; CI, 1.15-2.07). A similar pattern for higher odds of persistent use was observed for deployment and combat exposure, but not for smoking and mental health symptoms. Military occupation was not significantly associated with initiation or persistence. Conclusions Deployment and combat exposure in the US military are associated with increased risk of smokeless tobacco initiation and persistence while smoking and symptoms of post-traumatic stress disorder increase the odds for initiation. Research is needed on aspects of military service amenable to the reduction or prevention of tobacco consumption. C1 [Hermes, Eric D. A.] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06511 USA. [Wells, Timothy S.; Smith, Besa; Smith, Tyler C.] USN, Dept Deployment Hlth Res, Hlth Res Ctr, San Diego, CA 92152 USA. [Boyko, Edward J.] ERIC, VA Puget Sound, Seattle, WA USA. [Gackstetter, Gary G.] Analyt Serv Inc, Arlington, VA USA. [Miller, Shannon C.] USAF, Res Lab, Wright Patterson AFB, OH 45433 USA. [Miller, Shannon C.] Vet Affairs Med Ctr, Cincinnati, OH 45267 USA. [Miller, Shannon C.] Univ Cincinnati, Ctr Treatment Res & Educ Addict Disorders CeTREAD, Dept Psychiat & Behav Neurosci, Cincinnati, OH USA. RP Hermes, EDA (reprint author), Yale Univ, Sch Med, Dept Psychiat, Ste 901,300 George St, New Haven, CT 06511 USA. EM eric.hermes@yale.edu FU US Army Medical Research and Materiel Command, Fort Detrick, Maryland; Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland FX The authors state that they have no financial disclosures or other conflicts of interest in the design, analysis or preparation of this manuscript. The Millennium Cohort Study is funded through the Military Operational Medicine Research Program of the US Army Medical Research and Materiel Command, Fort Detrick, Maryland. The funding organization had no role in the design and conduct of the study; collection, analysis or preparation of data,; or preparation, review or approval of the manuscript.; The Millennium Cohort Study Team includes Gregory C. Gray MD, MPH (College of Public Health and Health Professions, University of Florida, Gainesville, Florida), James R. Riddle DVM, MPH (Air Force Research Laboratory, Wright-Patterson Air Force Base, Dayton, Ohio), Paul J. Amoroso MD, MPH (Madigan Army Medical Center, Fort Lewis, Washington), Tomoko I. Hooper MD, MPH (Uniformed Services University on the Health Sciences, Bethesda, Maryland) and Margaret A. K. Ryan MD, MPH (US Naval Hospital Camp Pendleton, Camp Pendleton, California). We are indebted to the Millennium Cohort Study participants, without whom these analyses would not be possible. We thank Scott L. SeggermanBS, MS, from the Defense Manpower Data Center, Seaside, California. We also thank the professionals from the US Army Medical Research and Materiel Command, especially those from the Military Operational Medicine Research Program, Fort Detrick, Maryland. We thank Melissa Bagnell MPH; Gina Creaven, MBA; James Davies BS; Gia Gumbs, MPH; Nisara Granado MPH, PhD; Lesley Henry BA; Dennis Hernando BS; Jaime Horton BS; Isabel Jacobson MPH; Kelly Jones MPH; Lauren Kipp BA; Cynthia LeardMann MPH; Travis Leleu BS; Gordon Lynch; Jamie McGrew BS; Hope McMaster PhD; Stacie Nguyen BS; Amanda Pietrucha MPH; Teresa Powell MS; Kari Sausedo MA; Amber Seelig MPH; Beverly Sheppard BS; Katherine Snell BS; Steven Speigle; Marleen Welsh PhD; Martin White MPH; James Whitmer; and CharleneWongMPH; from the Department of Deployment Health Research and Michelle LeWark BA, from the Naval Health Research Center, San Diego, California. We appreciate the support of the Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland. These individuals provided assistance as part of their official duties as employees of the Department of Defense and none received additional financial compensation. The VA Puget Sound provided support for Dr Boyko's participation in this research. NR 49 TC 8 Z9 8 U1 2 U2 6 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0965-2140 J9 ADDICTION JI Addiction PD MAY PY 2012 VL 107 IS 5 BP 983 EP 994 DI 10.1111/j.1360-0443.2011.03737.x PG 12 WC Substance Abuse; Psychiatry SC Substance Abuse; Psychiatry GA 919QW UT WOS:000302344500029 PM 22126651 ER PT J AU Woolpert, T Staples, JE Faix, DJ Nett, RJ Kosoy, OI Biggerstaff, BJ Johnson, BW Sracic, M Fischer, M AF Woolpert, Tabitha Staples, J. Erin Faix, Dennis J. Nett, Randall J. Kosoy, Olga I. Biggerstaff, Brad J. Johnson, Barbara W. Sracic, Michael Fischer, Marc TI Immunogenicity of one dose of Vero cell culture-derived Japanese encephalitis (JE) vaccine in adults previously vaccinated with mouse brain-derived JE vaccine SO VACCINE LA English DT Article DE Japanese encephalitis; Japanese encephalitis vaccines; Vaccines; Immunization ID IC51; PHASE-3; POINTS; SAFETY; TRIAL AB Background:There are no data on the use of inactivated Vero cell culture-derived Japanese encephalitis (JE) vaccine (JE-VC) as a booster among individuals who previously received inactivated mouse brain-derived JE vaccine (JE-MB). Methods: Military personnel who received >= 3 doses of JE-MB or were JE vaccine-naive were vaccinated with 2 doses of JE-VC on days 0 and 28. Serum neutralizing antibodies were measured pre-vaccination and 28 days after each dose. Non-inferiority was evaluated for seroprotection rate and geometric mean titer (GMT) between previously vaccinated participants post-dose 1 and vaccine-naive participants post-dose 2. Results: Fifty-three previously vaccinated and 70 JE vaccine-naive participants were enrolled. Previously vaccinated participants had significantly higher GMTs pre-vaccination, post-dose 1, and post-dose 2. Seroprotection rates among previously vaccinated participants post-dose 1 (44/44, 100%) were noninferior to those achieved in previously naive participants post-dose 2 (53/57, 93%). The GMT was significantly higher in previously vaccinated participants post-dose 1 (GMT 315; 95% CI 191-520) compared to previously naive participants post-dose 2 (GMT 79; 95% CI 54-114). Conclusions: Among military personnel previously vaccinated with >= 3 doses of JE-MB, a single dose of JE-VC adequately boosts neutralizing antibody levels and provides at least short-term protection. Additional studies are needed to confirm these findings in other populations and determine the duration of protection following a single dose of JE-VC in prior recipients of JE-MB. Published by Elsevier Ltd. C1 [Fischer, Marc] Ctr Dis Control & Prevent, Arboviral Dis Branch, Div Vector Borne Dis, Ft Collins, CO 80521 USA. [Sracic, Michael] US Marine Corps, Marine Expeditionary Unit 13, Camp Pendleton, CA 92055 USA. [Woolpert, Tabitha; Faix, Dennis J.] USN, Dept Operat Infect Dis, Hlth Res Ctr, San Diego, CA 92106 USA. RP Fischer, M (reprint author), Ctr Dis Control & Prevent, Arboviral Dis Branch, Div Vector Borne Dis, 3150 Rampart Rd, Ft Collins, CO 80521 USA. EM mfischer@cdc.gov FU Military Vaccine Agency [MILVAX 10-1-111] FX This work was supported by the Military Vaccine Agency's Medical Infectious Disease Research Program (MILVAX 10-1-111). NR 18 TC 11 Z9 12 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD APR 26 PY 2012 VL 30 IS 20 BP 3090 EP 3096 DI 10.1016/j.vaccine.2012.02.063 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 932PK UT WOS:000303302800007 PM 22406277 ER PT J AU Faix, DJ Hawksworth, AW Myers, CA Hansen, CJ Ortiguerra, RG Halpin, R Wentworth, D Pacha, LA Schwartz, EG Garcia, SMS Eick-Cost, AA Clagett, CD Khurana, S Golding, H Blair, PJ AF Faix, Dennis J. Hawksworth, Anthony W. Myers, Christopher A. Hansen, Christian J. Ortiguerra, Ryan G. Halpin, Rebecca Wentworth, David Pacha, Laura A. Schwartz, Erica G. Garcia, Shawn M. S. Eick-Cost, Angelia A. Clagett, Christopher D. Khurana, Surender Golding, Hana Blair, Patrick J. TI Decreased Serologic Response in Vaccinated Military Recruits during 2011 Correspond to Genetic Drift in Concurrent Circulating Pandemic A/H1N1 Viruses SO PLOS ONE LA English DT Article ID INACTIVATED INFLUENZA VACCINES; US NAVY SHIP; H1N1 VIRUS; RELATIVE EFFICACY; BASIC TRAINEES; YOUNG-CHILDREN; H5N1 VIRUS; LIVE; ADULTS; TRIVALENT AB Background: Population-based febrile respiratory illness surveillance conducted by the Department of Defense contributes to an estimate of vaccine effectiveness. Between January and March 2011, 64 cases of 2009 A/H1N1 (pH1N1), including one fatality, were confirmed in immunized recruits at Fort Jackson, South Carolina, suggesting insufficient efficacy for the pH1N1 component of the live attenuated influenza vaccine (LAIV). Methodology/Principal Findings: To test serologic protection, serum samples were collected at least 30 days post-vaccination from recruits at Fort Jackson (LAIV), Parris Island (LAIV and trivalent inactivated vaccine [TIV]) at Cape May, New Jersey (TIV) and responses measured against pre-vaccination sera. A subset of 78 LAIV and 64 TIV sera pairs from recruits who reported neither influenza vaccination in the prior year nor fever during training were tested by microneutralization (MN) and hemagglutination inhibition (HI) assays. MN results demonstrated that seroconversion in paired sera was greater in those who received TIV versus LAIV (74% and 37%). Additionally, the fold change associated with TIV vaccination was significantly different between circulating (2011) versus the vaccine strain (2009) of pH1N1 viruses (ANOVA p value = 0.0006). HI analyses revealed similar trends. Surface plasmon resonance (SPR) analysis revealed that the quantity, IgG/IgM ratios, and affinity of anti-HA antibodies were significantly greater in TIV vaccinees. Finally, sequence analysis of the HA1 gene in concurrent circulating 2011 pH1N1 isolates from Fort Jackson exhibited modest amino acid divergence from the vaccine strain. Conclusions/Significance: Among military recruits in 2011, serum antibody response differed by vaccine type (LAIV vs. TIV) and pH1N1 virus year (2009 vs. 2011). We hypothesize that antigen drift in circulating pH1N1 viruses contributed to reduce vaccine effectiveness at Fort Jackson. Our findings have wider implications regarding vaccine protection from circulating pH1N1 viruses in 2011-2012. C1 [Faix, Dennis J.; Hawksworth, Anthony W.; Myers, Christopher A.; Hansen, Christian J.; Ortiguerra, Ryan G.; Blair, Patrick J.] USN, Hlth Res Ctr, Dept Operat Infect Dis, San Diego, CA 92152 USA. [Halpin, Rebecca; Wentworth, David] J Craig Venter Inst, Viral Programs, Rockville, MD USA. [Pacha, Laura A.] Army Publ Hlth Command, Dis Epidemiol Program, Aberdeen Proving Ground, MD USA. [Schwartz, Erica G.] US Coast Guard, Washington, DC USA. [Garcia, Shawn M. S.] USN, Hosp Beaufort, Beaufort, SC USA. [Eick-Cost, Angelia A.] Armed Forces Hlth Surveillance Ctr, Div Epidemiol & Anal, Silver Spring, MD USA. [Clagett, Christopher D.] Navy & Marine Corps Publ Hlth Ctr, Portsmouth, VA USA. [Khurana, Surender; Golding, Hana] US FDA, Ctr Biol Evaluat & Res, Div Viral Prod, Bethesda, MD USA. RP Faix, DJ (reprint author), USN, Hlth Res Ctr, Dept Operat Infect Dis, San Diego, CA 92152 USA. EM patrick.blair@med.navy.mil RI Valle, Ruben/A-7512-2013; OI Wentworth, David/0000-0002-5190-980X FU U.S. Department of Defense Armed Forces Health Surveillance Center division of the Global Emerging Infections Surveillance and Response System; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services [HHSN272200900007C] FX This work was sponsored in part by a grant from the U.S. Department of Defense Armed Forces Health Surveillance Center division of the Global Emerging Infections Surveillance and Response System, and in part with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under contract number HHSN272200900007C. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 59 TC 9 Z9 9 U1 1 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 13 PY 2012 VL 7 IS 4 AR e34581 DI 10.1371/journal.pone.0034581 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 959UT UT WOS:000305341600045 PM 22514639 ER PT J AU Gorham, ED Garland, CF Burgi, A Mohr, SB Zeng, K Hofflich, H Ricordi, C AF Gorham, Edward Doerr Garland, Cedric Frank Burgi, Alina Mohr, Sharif Burgette Zeng, Kenneth Hofflich, Heather Ricordi, Camillo TI Lower prediagnostic serum 25-hydroxyvitamin D concentration is associated with increased incidence of type 1 diabetes in the U. S. military: a nested case-control study SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Gorham, Edward Doerr] USN, Hlth Res Ctr, SSO, San Diego, CA 92152 USA. [Gorham, Edward Doerr] U Calif San Diego, Fam & Prevent Med, La Jolla, CA USA. [Garland, Cedric Frank] U Calif San Diego, Family & Prevent Med, La Jolla, CA USA. [Hofflich, Heather] Univ Calif San Diego, Internal Med Grp, La Jolla, CA 92093 USA. [Mohr, Sharif Burgette] NHRC, San Diego, CA USA. [Ricordi, Camillo] Univ Miami FL, Diabet Res Inst, Hollywood, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711306760 ER PT J AU Mohr, SB Gorham, ED Alcaraz, JE Kane, CI Macera, CA Parsons, JK Wingard, DL Horst, R Garland, CF AF Mohr, Sharif Burgette Gorham, Edward D. Alcaraz, John E. Kane, C. I. Macera, Caroline A. Parsons, J. Kelley Wingard, Deborah L. Horst, R. Garland, C. F. TI Serum 25-hydroxyvitamin D and breast cancer in the military: A nested case-control study SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Mohr, Sharif Burgette; Kane, C. I.] Univ Calif San Diego, La Jolla, CA 92093 USA. [Gorham, Edward D.] USN, SSO, Hlth Res Ctr, San Diego, CA 92152 USA. [Gorham, Edward D.; Parsons, J. Kelley; Wingard, Deborah L.; Garland, C. F.] UCSD, La Jolla, CA USA. [Alcaraz, John E.; Macera, Caroline A.] San Diego State Univ, Grad Sch Publ Hlth, San Diego, CA 92182 USA. [Horst, R.] Heartland Assays, Ames, IA USA. [Garland, C. F.] NHRC, San Diego, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711306415 ER PT J AU Rodriguez-Soto, AE Jensen, A Mayfield, J Jaworski, R Frank, L Ward, SR Kelly, K AF Rodriguez-Soto, Ana Elvira Jensen, Andrew Mayfield, Jarrott Jaworski, Rebecca Frank, Lawrence Ward, Samuel Richard Kelly, Karen TI Load-Carrying Lumbar Spine Kinematics in Active-Duty Marines SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Rodriguez-Soto, Ana Elvira; Frank, Lawrence; Ward, Samuel Richard] Univ Calif San Diego, Dept Radiol, La Jolla, CA 92093 USA. [Rodriguez-Soto, Ana Elvira; Frank, Lawrence; Ward, Samuel Richard] Univ Calif San Diego, Dept Orthopaed Surg, La Jolla, CA 92093 USA. [Rodriguez-Soto, Ana Elvira; Frank, Lawrence; Ward, Samuel Richard] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA. [Jensen, Andrew; Mayfield, Jarrott; Kelly, Karen] San Diego State Univ, Sch Exercise & Nutr Sci, San Diego, CA 92182 USA. [Jaworski, Rebecca; Kelly, Karen] USN, Dept Warfighter Performance, Hlth Res Ctr, San Diego, CA 92152 USA. [Frank, Lawrence] VA San Diego, San Diego, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711300818 ER PT J AU Hoffer, M Balaban, C Gottshall, K AF Hoffer, Michael Balaban, Carey Gottshall, Kim TI Dizziness patterns as traumatic brain injury markers: Prognostic and treatment implications SO BRAIN INJURY LA English DT Meeting Abstract C1 [Hoffer, Michael; Gottshall, Kim] Spatial Orientat Ctr, San Diego, CA USA. NMCSD, Dept Otolarynol, San Diego, CA USA. [Balaban, Carey] Univ Pittsburgh, Dept Otolarynol, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0269-9052 J9 BRAIN INJURY JI Brain Inj. PD APR-MAY PY 2012 VL 26 IS 4-5 MA 0097 BP 346 EP 347 PG 2 WC Neurosciences; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA 943EZ UT WOS:000304104600074 ER PT J AU Haran, J Creason, A Campbell, J Stentz, L Wolde, M Garcia, K Wing, S Tsao, J AF Haran, Jay Creason, Alia Campbell, Justin Stentz, Lauren Wolde, Mikias Garcia, Kevin Wing, Sherry Tsao, Jack TI Tbi Surveillance In Redeploying Marines SO BRAIN INJURY LA English DT Meeting Abstract C1 [Creason, Alia; Stentz, Lauren; Wolde, Mikias; Garcia, Kevin; Wing, Sherry; Tsao, Jack] USN, Bur Med & Surg, Washington, DC USA. [Haran, Jay] USN, Naval Air Syst Command, Patuxent River, MD USA. [Campbell, Justin] USN, Space & Naval Warfare Syst Command, San Diego, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0269-9052 J9 BRAIN INJURY JI Brain Inj. PD APR-MAY PY 2012 VL 26 IS 4-5 MA 0791 BP 724 EP 724 PG 1 WC Neurosciences; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA 943EZ UT WOS:000304104600735 ER PT J AU Bonanno, GA Mancini, AD Horton, JL Powell, TM LeardMann, CA Boyko, EJ Wells, TS Hooper, TI Gackstetter, GD Smith, TC AF Bonanno, George A. Mancini, Anthony D. Horton, Jaime L. Powell, Teresa M. LeardMann, Cynthia A. Boyko, Edward J. Wells, Timothy S. Hooper, Tomoko I. Gackstetter, Gary D. Smith, Tyler C. CA Millennium Cohort Study Team TI Trajectories of trauma symptoms and resilience in deployed US military service members: prospective cohort study SO BRITISH JOURNAL OF PSYCHIATRY LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; MILLENNIUM COHORT; COMBAT EXPOSURE; SMALLPOX VACCINATION; ALCOHOL-USE; MIXTURE; IRAQ; CARE; VETERANS AB Background Most previous attempts to determine the psychological cost of military deployment have been limited by reliance on convenience samples, lack of pre-deployment data or confidentiality and cross-sectional designs. Aims This study addressed these limitations using a population-based, prospective cohort of US military personnel deployed in support of the operations in Iraq and Afghanistan. Method The sample consisted of US military service members in all branches including active duty, reserve and national guard who deployed once (n=3393) or multiple times (n=4394). Self-reported symptoms of post-traumatic stress were obtained prior to deployment and at two follow-ups spaced 3 years apart. Data were examined for longitudinal trajectories using latent growth mixture modelling. Results Each analysis revealed remarkably similar post-traumatic stress trajectories across time. The most common pattern was low-stable post-traumatic stress or resilience (83.1% single deployers, 84.9% multiple deployers), moderate-improving (8.0%, 8.5%), then worsening-chronic post-traumatic stress (6.7%, 4.5%), high-stable (2.2% single deployers only) and high-improving (2.2% multiple deployers only). Covariates associated with each trajectory were identified. Conclusions The final models exhibited similar types of trajectories for single and multiple deployers; most notably, the stable trajectory of low post-traumatic stress pre- to post-deployment, or resilience, was exceptionally high. Several factors predicting trajectories were identified, which we hope will assist in future research aimed at decreasing the risk of post-traumatic stress disorder among deployers. C1 [Bonanno, George A.] Columbia Univ, Dept Counseling & Clin Psychol, Teachers Coll, New York, NY 10027 USA. [Mancini, Anthony D.] Pace Univ, Dept Psychol, Pleasantville, NY USA. [Horton, Jaime L.; Powell, Teresa M.; LeardMann, Cynthia A.; Wells, Timothy S.; Smith, Tyler C.] USN, Dept Deployment Hlth Res, Hlth Res Ctr, San Diego, CA 92152 USA. [Boyko, Edward J.] Vet Affairs Med Ctr, Seattle Epidemiol Res & Informat Ctr, Seattle, WA 98108 USA. [Hooper, Tomoko I.; Gackstetter, Gary D.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Gackstetter, Gary D.] Analyt Serv Inc ANSER, Arlington, VA USA. RP Bonanno, GA (reprint author), Columbia Univ, Dept Counseling & Clin Psychol, Teachers Coll, 525 W 120th St,Box 218, New York, NY 10027 USA. EM gab38@columbia.edu FU US Army Medical Research and Materiel Command, Fort Detrick, Maryland; Department of Defense [60002]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland FX The Millennium Cohort Study is funded through the Military Operational Medicine Research Program of the US Army Medical Research and Materiel Command, Fort Detrick, Maryland. This represents report 11-08, supported by the Department of Defense, under work unit no. 60002. The funding organisation had no role in the design and conduct of the study; collection, analysis, or preparation of data; or preparation, review or approval of the manuscript. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of the Army, Department of the Air Force, Department of Defense, Department of Veterans Affairs or the US government. Resources from the VA Puget Sound Health Care System supported E.J.B.'s involvement in this research.; We thank Scott L Seggerman from the Management Information Division, Defense Manpower Data Center, Seaside, California. We also thank Michelle LeWark from the Naval Health Research Center. We thank the professionals from the US Army Medical Research and Materiel Command, especially those from the military Operational Medicine Research Program, Fort Detrick, Maryland. We appreciate the support of the Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland. We are indebted to all the members of the Millennium Cohort for their participation in this important project. In addition to the authors, the Millennium Cohort Study Team includes Melissa Bagnell, Gina Creaven, James Davies, Nisara Granado, Dennis Hernando, Isabel Jacobson, Kelly Jones, Travis Leleu, Gordon Lynch, Jamie McGrew, Hope McMaster, Amanda Pietrucha, Amber Seelig, Beverly Sheppard, Besa Smith, Katherine Snell, Steven Speigle, Karl Sausedo, Martin White, James Whitmer, and Charlene Wong, from the Deployment Health Research Department Naval Health Research Center, San Diego, California. NR 44 TC 109 Z9 109 U1 6 U2 42 PU ROYAL COLLEGE OF PSYCHIATRISTS PI LONDON PA BRITISH JOURNAL OF PSYCHIATRY 17 BELGRAVE SQUARE, LONDON SW1X 8PG, ENGLAND SN 0007-1250 J9 BRIT J PSYCHIAT JI Br. J. Psychiatry PD APR PY 2012 VL 200 IS 4 BP 317 EP 323 DI 10.1192/bjp.bp.111.096552 PG 7 WC Psychiatry SC Psychiatry GA 930NP UT WOS:000303146400010 PM 22361018 ER PT J AU Cheng, KG Ortiz, DJ Weiss, RE Shi, L Ovalle-Bahamon, RE Ernesto, F Grillo, MP Bing, EG AF Cheng, Karen G. Ortiz, Daniel J. Weiss, Robert E. Shi, Lu Ovalle-Bahamon, Ricardo E. Ernesto, Francisco Grillo, Michael P. Bing, Eric G. TI Patterns of alcohol consumption and factors influencing problematic drinking among Angolan soldiers SO JOURNAL OF SUBSTANCE USE LA English DT Article DE Alcohol; mental health; sub-Saharan Africa; military ID POSTTRAUMATIC-STRESS-DISORDER; UK ARMED-FORCES; SUBSTANCE USE; MENTAL-HEALTH; GENERAL-POPULATION; COLLEGE-STUDENTS; YOUNG-ADULTS; MILITARY; RELIGIOSITY; VETERANS AB Alcohol prevention strategies for soldiers in sub-Saharan African countries suffer from limited knowledge about soldiers' alcohol consumption patterns. The present study was conducted to understand such patterns in Angolan soldiers, including associated risk and protective factors. From 12 military bases, 568 soldiers completed structured interviews that assessed demographic information, level of alcohol consumption, mental health, social support and religious activity. Logistic regressions were used to determine factors associated with any alcohol intake, problematic drinking, binge drinking and alcohol consumption prior to sexual activity. Nearly 35% of participants exhibited problematic drinking behaviour on the Alcohol Use Disorders Identification Test. Approximately 26% reported at least one incidence of binge drinking during the past year; 16% described having recently consumed alcohol before sexual activity. Risk factors included being older, being unmarried, having poorer mental health or increased number of traumatic events and socialising with family and friends two to four times a month. Attending religious services more than once a week appeared to protect against problematic drinking. Results emphasise the need for effective alcohol prevention campaigns in Angola and for targeting efforts towards individuals exhibiting the observed high-risk characteristics. C1 [Cheng, Karen G.; Ortiz, Daniel J.; Shi, Lu; Ovalle-Bahamon, Ricardo E.; Bing, Eric G.] Charles R Drew Univ Med & Sci, Dept Psychiat & Human Behav, Los Angeles, CA 90059 USA. [Weiss, Robert E.] Univ Calif Los Angeles, Sch Publ Hlth, Dept Biostat, Los Angeles, CA 90024 USA. [Ernesto, Francisco] Angolan Armed Forces, Luanda, Angola. [Grillo, Michael P.] US Naval Hlth Res Ctr, San Diego, CA USA. RP Cheng, KG (reprint author), Charles R Drew Univ Med & Sci, Dept Psychiat & Human Behav, 1731 E 120th St,Bldg N, Los Angeles, CA 90059 USA. EM karencheng@cdrewu.edu NR 53 TC 3 Z9 3 U1 3 U2 8 PU INFORMA HEALTHCARE PI NEW YORK PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA SN 1465-9891 J9 J SUBST USE JI J. Subst. Use PD APR PY 2012 VL 17 IS 2 BP 138 EP 149 DI 10.3109/14659891.2010.538462 PG 12 WC Substance Abuse SC Substance Abuse GA 929NT UT WOS:000303073100005 ER PT J AU Schmitz, KJ Schmied, EA Webb-Murphy, JA Hammer, PS Larson, GE Conway, TL Galarneau, MR Boucher, WC Edwards, NK Johnson, DC AF Schmitz, Kimberly J. Schmied, Emily A. Webb-Murphy, Jennifer A. Hammer, Paul S. Larson, Gerald E. Conway, Terry L. Galarneau, Michael R. Boucher, Wayne C. Edwards, Nathan K. Johnson, Douglas C. TI Psychiatric Diagnoses and Treatment of U.S. Military Personnel While Deployed to Iraq SO MILITARY MEDICINE LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; COMBAT DEPLOYMENT; SERVICE MEMBERS; ALCOHOL MISUSE; WAR VETERANS; AFGHANISTAN; SOLDIERS; THEATER; SYMPTOMS AB Military personnel deployed in support of combat operations are at significantly higher risk for mental health problems. However, much of what we know about combat-related mental health comes from postdeployment assessments. This study describes the mental health of 1,336 treatment-seeking deployed U.S. military personnel and interventions recommended by military mental health providers in Iraq from January 2006 to January 2007. Cases were primarily young enlisted men, most of whom were on their first combat deployment. Marines made up the majority of the cases (60%), but there were also large numbers of Army and Navy personnel. The most common psychiatric diagnoses were anxiety disorders (31%, including 11% with posttraumatic stress disorder), followed by adjustment (27%) and mood disorders (25%, including 22% with depression). Medication was the most commonly prescribed treatment for patients with psychiatric diagnoses but was often combined with recommendations for psychotherapy/counseling and/or behavioral modifications. The findings illustrate the distribution of mental health conditions seen among treatment-seeking troops while actively serving in a combat environment and the interventions recommended for them. Further examination of postdeployment health outcomes may help to facilitate the development of more effective acute intervention strategies in theater. C1 [Schmitz, Kimberly J.; Webb-Murphy, Jennifer A.] USN, Ctr Combat & Operat Stress Control, San Diego, CA 92134 USA. [Schmied, Emily A.; Larson, Gerald E.; Conway, Terry L.; Galarneau, Michael R.; Edwards, Nathan K.; Johnson, Douglas C.] USN, Hlth Res Ctr, San Diego, CA 92106 USA. [Hammer, Paul S.] Def Ctr Excellence Psychol Hlth & Traumat Brain I, Arlington, VA 22202 USA. [Boucher, Wayne C.] Operat Stress Control & Readiness Program, Div Surg Off, Marine Div 1, Camp Pendleton, CA 92055 USA. RP Schmitz, KJ (reprint author), USN, Ctr Combat & Operat Stress Control, 34960 Bob Wilson Dr,Suite 400, San Diego, CA 92134 USA. FU U.S. Department of Defense, Navy Bureau of Medicine and Surgery FX The authors acknowledge the contributions of Hoa Ly. BS, in readying the data for analysis and Kara K. Ballenger, MPH, in critically reviewing the manuscript. This work was supported by the U.S. Department of Defense, Navy Bureau of Medicine and Surgery. NR 37 TC 7 Z9 7 U1 1 U2 5 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2012 VL 177 IS 4 BP 380 EP 389 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA 921BF UT WOS:000302452300008 PM 22594127 ER PT J AU Schmied, E Parada, H Madanat, H Horton, LA Ayala, GX AF Schmied, Emily Parada, Humberto Madanat, Hala Horton, Lucy A. Ayala, Guadalupe X. TI PSYCHOSOCIAL CORRELATES OF BEHAVIORAL STRATEGIES FOR HEALTHY EATING AMONG LATINAS IN IMPERIAL COUNTY, CALIFORNIA SO ANNALS OF BEHAVIORAL MEDICINE LA English DT Meeting Abstract C1 [Schmied, Emily] USN, Hlth Res Ctr, San Diego, CA 92106 USA. [Schmied, Emily; Parada, Humberto; Madanat, Hala; Horton, Lucy A.; Ayala, Guadalupe X.] Inst Behav & Community Hlth, San Diego, CA USA. EM emily.schmied@med.navy.mil NR 0 TC 0 Z9 0 U1 0 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0883-6612 J9 ANN BEHAV MED JI Ann. Behav. Med. PD APR PY 2012 VL 43 SU 1 BP S189 EP S189 PG 1 WC Psychology, Multidisciplinary SC Psychology GA 916HQ UT WOS:000302092400733 ER PT J AU Schmied, E McRoy, RM Larson, GE AF Schmied, Emily McRoy, Robyn M. Larson, Gerald E. TI PSYCHOSOCIAL CORRELATES OF SELF-RATED HEALTH IN MILITARY PERSONNEL WITH MULTIPLE PHYSICAL COMPLAINTS SO ANNALS OF BEHAVIORAL MEDICINE LA English DT Meeting Abstract C1 [Schmied, Emily; McRoy, Robyn M.; Larson, Gerald E.] USN, Hlth Res Ctr, San Diego, CA 92106 USA. EM emily.schmied@med.navy.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0883-6612 J9 ANN BEHAV MED JI Ann. Behav. Med. PD APR PY 2012 VL 43 SU 1 BP S114 EP S114 PG 1 WC Psychology, Multidisciplinary SC Psychology GA 916HQ UT WOS:000302092400441 ER PT J AU Crum-Cianflone, NF Collins, G Defang, G Iverson, E Eberly, LE Duplessis, C Maguire, J Ganesan, A Agan, BK Lalani, T Whitman, T Brandt, C Faix, D Blair, PJ Burgess, T AF Crum-Cianflone, N. F. Collins, G. Defang, G. Iverson, E. Eberly, L. E. Duplessis, C. Maguire, J. Ganesan, A. Agan, B. K. Lalani, T. Whitman, T. Brandt, C. Faix, D. Blair, P. J. Burgess, T. TI Immunoglobulin G subclass levels and antibody responses to the 2009 influenza A (H1N1) monovalent vaccine among human immunodeficiency virus (HIV)-infected and HIV-uninfected adults SO CLINICAL AND EXPERIMENTAL IMMUNOLOGY LA English DT Article DE H1N1; IgG2; IgG levels; immunity; influenza vaccine responses ID IGG; POLYSACCHARIDE; INFECTIONS; IMMUNOGENICITY; DEFICIENCIES; PNEUMONIA; CHILDREN AB Immunoglobulin (Ig)G levels are important for antibody vaccine responses and IgG subclass deficiencies have been associated with severe 2009 influenza A (H1N1) infections. Studies have demonstrated variations in immune responses to the H1N1 vaccine, but the aetiology of this is unknown. We determined the associations between pre-vaccination overall and influenza-specific IgG subclass levels and 2009 H1N1-specific antibody responses post-vaccination (robust versus poor at day 28) stratified by human immunodeficiency virus (HIV) status. Logistic regression models were utilized to evaluate whether pre-vaccination IgG subclass levels were associated with the antibody response generated post-vaccination. We evaluated 48 participants as part of a clinical study who were stratified by robust versus poor post-vaccination immune responses. Participants had a median age of 35 years; 92% were male and 44% were Caucasian. HIV-infected adults had a median CD4 count of 669 cells/mm3, and 79% were receiving highly active anti-retroviral therapy. HIV-infected participants were more likely to have IgG2 deficiency (<240 mg/dl) than HIV-uninfected individuals (62% versus 4%, P < 0.001). No association of pre-vaccination IgG subclass levels (total or influenza-specific) and the antibody response generated by HIN1 vaccination in either group was found. In summary, pre-vaccination IgG subclass levels did not correlate with the ability to develop robust antibody responses to the 2009 influenza A (H1N1) monovalent vaccine. IgG2 deficiencies were common among HIV-infected individuals but did not correlate with poor influenza vaccine responses. Further investigations into the aetiology of disparate vaccine responses are needed. C1 [Crum-Cianflone, N. F.] USN, Infect Dis Clin, Clin Investigat Dept KCA, San Diego Med Ctr, San Diego, CA 92134 USA. [Crum-Cianflone, N. F.; Collins, G.; Iverson, E.; Eberly, L. E.; Maguire, J.; Ganesan, A.; Agan, B. K.; Lalani, T.; Whitman, T.; Brandt, C.; Burgess, T.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Defang, G.; Burgess, T.] USN, Med Res Ctr, Bethesda, MD 20084 USA. [Ganesan, A.; Whitman, T.] Natl Naval Med Ctr, Infect Dis Clin, Bethesda, MD USA. [Crum-Cianflone, N. F.; Faix, D.; Blair, P. J.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Collins, G.; Iverson, E.; Eberly, L. E.] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Maguire, J.; Lalani, T.] USN, Infect Dis Clin, Med Ctr, Portsmouth, VA USA. RP Crum-Cianflone, NF (reprint author), USN, Infect Dis Clin, Clin Investigat Dept KCA, San Diego Med Ctr, 34800 Bob Wilson Dr,Ste 5, San Diego, CA 92134 USA. EM nancy.crum@med.navy.mil RI Valle, Ruben/A-7512-2013; OI Eberly, Lynn/0000-0003-4763-330X; Agan, Brian/0000-0002-5114-1669 FU Department of Defense (DoD) through the Uniformed Services University of the Health Sciences [IDCRP-053]; National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) [Y1-AI-5072]; Armed Forces Health Surveillance Center's Global Emerging Infections System [I204_10] FX Support for this work (IDCRP-053) was provided by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072. In addition, funding was provided by the Armed Forces Health Surveillance Center's Global Emerging Infections System via project I204_10. The content of this publication is the sole responsibility of the authors and does not necessarily reflect the views or policies of the NIH or the Department of Health and Human Services, the US Government, the DoD or the Departments of the Army, Navy or Air Force. Mention of trade names, commercial products or organizations does not imply endorsement by the US Government. The authors acknowledge that research protocol (IDCRP-053, 'Immunogenicity of Novel H1N1 Vaccination among HIV-Infected Compared to HIV-Uninfected Persons') received applicable Institutional Review Board review and approval. We certify that all individuals who qualify as authors have been listed; each has participated in the conception and design of this work, the writing of the document, and the approval of the submission of this version; that the document represents valid work; that if we used information derived from another source, we obtained all necessary approvals to use it and made appropriate acknowledgements in the document; and that each takes public responsibility for it. Nothing in the presentation implies any Federal/DOD/DON endorsement. NR 15 TC 6 Z9 6 U1 0 U2 3 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0009-9104 J9 CLIN EXP IMMUNOL JI Clin. Exp. Immunol. PD APR PY 2012 VL 168 IS 1 BP 135 EP 141 DI 10.1111/j.1365-2249.2011.04550.x PG 7 WC Immunology SC Immunology GA 901NU UT WOS:000300974800019 PM 22385248 ER PT J AU Davis, MC Baldwin, LC Groshens, TJ AF Davis, Matthew C. Baldwin, Lawrence C. Groshens, Thomas J. TI Synthesis of a (thienylethenyl)benzimidazole platinum acetylide complex SO TETRAHEDRON LETTERS LA English DT Article DE Platinum acetylide; Sonogashira; Alkyne; Thiophene; Benzimidazole ID PHOSPHINE COMPLEXES; CIS; P-31 AB A new platinum acetylide complex based on 6-dialkylaminobenzimidazol-2-yl-vinyl-2-thiophene-5-ylethyne was synthesized in seven steps and 2% overall yield. Published by Elsevier Ltd. C1 [Davis, Matthew C.; Baldwin, Lawrence C.; Groshens, Thomas J.] USN, Chem & Mat Div, Michelson Lab, Air Warfare Ctr, China Lake, CA 93555 USA. RP Davis, MC (reprint author), USN, Chem & Mat Div, Michelson Lab, Air Warfare Ctr, China Lake, CA 93555 USA. EM matthew.davis@navy.mil FU Air Force Research Laboratory FX Thanks to Thomas Cooper, PhD of the Air Force Research Laboratory for financial support of this research. Thanks to Geoffrey Lindsay, PhD (NAWCWD) for advice and encouragement throughout the course of this work. Thanks to Ann Moorehead of our Technical Library for collecting Refs. 6, 10 and 11. NR 26 TC 4 Z9 4 U1 1 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0040-4039 J9 TETRAHEDRON LETT JI Tetrahedron Lett. PD MAR 28 PY 2012 VL 53 IS 13 BP 1564 EP 1566 DI 10.1016/j.tetlet.2012.01.023 PG 3 WC Chemistry, Organic SC Chemistry GA 911BN UT WOS:000301692400008 ER PT J AU Landrum, ML Hullsiek, KH O'Connell, RJ Chun, HM Ganesan, A Okulicz, JF Lalani, T Weintrob, AC Crum-Cianflone, NF Agan, BK AF Landrum, Michael L. Hullsiek, Katherine Huppler O'Connell, Robert J. Chun, Helen M. Ganesan, Anuradha Okulicz, Jason F. Lalani, Tahaniyat Weintrob, Amy C. Crum-Cianflone, Nancy F. Agan, Brian K. CA HIV Working Grp TI Hepatitis B Vaccine Antibody Response and the Risk of Clinical AIDS or Death SO PLOS ONE LA English DT Article ID DELAYED-TYPE HYPERSENSITIVITY; HUMAN-IMMUNODEFICIENCY-VIRUS; HIV-INFECTED INDIVIDUALS; US MILITARY COHORT; T-CELL; REPLICATIVE SENESCENCE; ANTIRETROVIRAL THERAPY; CD4 COUNT; IN-VITRO; HAART AB Background: Whether seroresponse to a vaccine such as hepatitis B virus (HBV) vaccine can provide a measure of the functional immune status of HIV-infected persons is unknown. This study evaluated the relationship between HBV vaccine seroresponses and progression to clinical AIDS or death. Methods and Findings: From a large HIV cohort, we evaluated those who received HBV vaccine only after HIV diagnosis and had anti-HBs determination 1-12 months after the last vaccine dose. Non-response and positive response were defined as anti-HBs <10 and >= 10 IU/L, respectively. Participants were followed from date of last vaccination to clinical AIDS, death, or last visit. Univariate and multivariable risk of progression to clinical AIDS or death were evaluated with Cox regression models. A total of 795 participants vaccinated from 1986-2010 were included, of which 41% were responders. During 3,872 person-years of observation, 122 AIDS or death events occurred (53% after 1995). Twenty-two percent of non-responders experienced clinical AIDS or death compared with 5% of responders (p<0.001). Non-response to HBV vaccine was associated with a greater than 2-fold increased risk of clinical AIDS or death (HR 2.47; 95% CI, 1.38-4.43) compared with a positive response, after adjusting for CD4 count, HIV viral load, HAART use, and delayed type hypersensitivity skin test responses (an in vivo marker of cell-mediated immunity). This association remained evident among those with CD4 count >= 500 cells/mm(3) (HR 3.40; 95% CI, 1.39-8.32). Conclusions: HBV vaccine responses may have utility in assessing functional immune status and risk stratificating HIV-infected individuals, including those with CD4 count >= 500 cells/mm(3). C1 [Landrum, Michael L.; Hullsiek, Katherine Huppler; Ganesan, Anuradha; Lalani, Tahaniyat; Weintrob, Amy C.; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Landrum, Michael L.; Okulicz, Jason F.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Hullsiek, Katherine Huppler] Univ Minnesota, Minneapolis, MN USA. [O'Connell, Robert J.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Chun, Helen M.; Crum-Cianflone, Nancy F.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Ganesan, Anuradha; Weintrob, Amy C.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. RP Landrum, ML (reprint author), Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. EM mlandrum@idcrp.org OI Agan, Brian/0000-0002-5114-1669; Eberly, Lynn/0000-0003-4763-330X FU Department of Defense (DoD) [IDCRP-000-25]; National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement [Y1-AI-5072] FX Support for this work (IDCRP-000-25) was provided by the Infectious Disease Clinical Research Program (IDCRP, www.idcrp.org), a Department of Defense (DoD) program executed through Uniformed Services University of the Health Sciences. This project has been funded with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072. The IDCRP reviewed the study design, collected the data, and provided salary support to investigators (M.L.L., A.G., T.L., A.C.W., and B.K.A.). The analyses, conclusions and decision to submit the manuscript are the independent work and decision of the authors. The content of this publication is the sole responsibility of the authors and does not necessarily reflect the views or policies of the NIH or the Department of Health and Human Services, the DoD or the Departments of the Army, Navy or Air Force. Mention of trade names, commercial products, or organizations does not imply endorsement by the U.S. Government. NR 43 TC 5 Z9 5 U1 0 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 22 PY 2012 VL 7 IS 3 AR e33488 DI 10.1371/journal.pone.0033488 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 940QX UT WOS:000303909200032 PM 22457767 ER PT J AU Wu, CT Valls, OT Halterman, K AF Wu, Chien-Te Valls, Oriol T. Halterman, Klaus TI Reentrant Superconducting Phase in Conical-Ferromagnet-Superconductor Nanostructures SO PHYSICAL REVIEW LETTERS LA English DT Article ID MAGNETIC-PROPERTIES; ERRH4B4; TRANSITION AB We study a bilayer consisting of an ordinary superconductor and a magnet with a spiral magnetic structure of the Ho type. We use a self-consistent solution of the Bogolioubov-de Gennes equations to evaluate the pair amplitude, the transition temperature, and the thermodynamic functions, namely, the free energy and entropy. We find that for a range of thicknesses of the magnetic layer the superconductivity is reentrant with temperature T: as one lowers T the system turns superconducting, and when T is further lowered it turns normal again. This behavior is reflected in the condensation free energy and the pair potential, which vanish both above the upper transition and below the lower one. The transition is strictly reentrant: the low and high temperature phases are the same. The entropy further reveals a range of temperatures where the superconducting state is less ordered than the normal one. C1 [Wu, Chien-Te; Valls, Oriol T.] Univ Minnesota, Sch Phys & Astron, Minneapolis, MN 55455 USA. [Halterman, Klaus] USN, Michelson Lab, Div Phys, Air Warfare Ctr, China Lake, CA 93555 USA. [Valls, Oriol T.] Univ Minnesota, Minnesota Supercomp Inst, Minneapolis, MN 55455 USA. RP Wu, CT (reprint author), Univ Minnesota, Sch Phys & Astron, Minneapolis, MN 55455 USA. EM wu@physics.umn.edu; otvalls@umn.edu; klaus.halterman@navy.mil RI Halterman, Klaus/G-3826-2012 NR 34 TC 17 Z9 17 U1 0 U2 6 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 EI 1079-7114 J9 PHYS REV LETT JI Phys. Rev. Lett. PD MAR 16 PY 2012 VL 108 IS 11 AR 117005 DI 10.1103/PhysRevLett.108.117005 PG 5 WC Physics, Multidisciplinary SC Physics GA 909NK UT WOS:000301571200015 PM 22540503 ER PT J AU Simmons, AN Fitzpatrick, S Strigo, IA Potterat, EG Johnson, DC Matthews, SC Van Orden, KF Swain, JL Paulus, MP AF Simmons, Alan N. Fitzpatrick, Summer Strigo, Irina A. Potterat, Eric G. Johnson, Douglas C. Matthews, Scott C. Van Orden, Karl F. Swain, Judith L. Paulus, Martin P. TI Altered insula activation in anticipation of changing emotional states: neural mechanisms underlying cognitive flexibility in special operations forces personnel SO NEUROREPORT LA English DT Article DE anticipation; emotional set-shifting; insula; interoception resilience; SEALs ID POSTTRAUMATIC-STRESS-DISORDER; FUNCTIONAL MAGNETIC-RESONANCE; MAJOR DEPRESSIVE DISORDER; AVERSIVE VISUAL-STIMULI; RIGHT ANTERIOR INSULA; NEUROANATOMY; PERFORMANCE; ANXIETY; FMRI AB Individuals who perform optimally in extreme conditions, such as elite military warriors, can provide valuable insight into the neurobehavioral mechanisms underlying extraordinary performance. In the current study, we examined the degree to which Navy SEALs, when compared with healthy volunteers, could show more right anterior insula activation when shifting from anticipating one emotion to another during functional MRI. Consistent with our hypothesis, SEALs showed attenuated insula activation to negative image relative to positive image anticipation and greater right anterior insula activation during affective set-shifting. These findings suggest that elite warriors show combined (a) minimal reactivity during negative stimuli and (b) an enhanced ability to efficiently change their physiological state. These neural changes may underlie their ability to perform well in stressful situations. NeuroReport 23:234-239 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. C1 [Simmons, Alan N.; Fitzpatrick, Summer; Strigo, Irina A.; Johnson, Douglas C.; Matthews, Scott C.; Swain, Judith L.; Paulus, Martin P.] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92093 USA. [Simmons, Alan N.; Strigo, Irina A.; Matthews, Scott C.; Paulus, Martin P.] Vet Affairs San Diego Healthcare Syst, San Diego, CA USA. [Potterat, Eric G.; Johnson, Douglas C.; Van Orden, Karl F.; Swain, Judith L.; Paulus, Martin P.] OptiBrain Consortium, San Diego, CA USA. [Potterat, Eric G.] USN, SpecialWarfare Grp 1, San Diego, CA 92152 USA. [Johnson, Douglas C.; Van Orden, Karl F.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Fitzpatrick, Summer] Univ Texas Austin, Austin, TX 78712 USA. [Swain, Judith L.] Singapore Inst Clin Sci A STAR, Singapore, Singapore. [Swain, Judith L.] Natl Univ Singapore, Singapore 117548, Singapore. RP Simmons, AN (reprint author), Univ Calif San Diego, Dept Psychiat, Mailcode 0151B,9500 Gilman Dr, San Diego, CA 92093 USA. EM ansimmons@ucsd.edu RI Simmons, Alan/A-9815-2008; strigo, irina/L-9882-2016 OI Simmons, Alan/0000-0003-3963-2112; strigo, irina/0000-0002-8799-716X FU Veterans Administration; Clinical Science R&D Career Development Award; Center of Excellence in Stress and Mental Health; NARSAD FX The views expressed in this article are those of the authors and do not reflect the official policy or position of the Navy, Department of Defense, or the US Government. This research has been conducted in compliance with all applicable federal regulations governing the protection of human participants in research. This work was supported by the Veterans Administration through Merit Grant (ANS, MPP), Clinical Science R&D Career Development Award (SCM), and the Center of Excellence in Stress and Mental Health (ANS, MPP), in addition to funding from a NARSAD Young Investigator Award (ANS). NR 24 TC 13 Z9 13 U1 0 U2 12 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0959-4965 J9 NEUROREPORT JI Neuroreport PD MAR 7 PY 2012 VL 23 IS 4 BP 234 EP 239 DI 10.1097/WNR.0b013e3283503275 PG 6 WC Neurosciences SC Neurosciences & Neurology GA 894DW UT WOS:000300408200008 PM 22222502 ER PT J AU Knowles, PL Kiger, KT AF Knowles, Philip L. Kiger, Ken T. TI Quantification of dispersed phase concentration using light sheet imaging methods SO EXPERIMENTS IN FLUIDS LA English DT Article ID LASER-INDUCED FLUORESCENCE; PARTICLE CONCENTRATION; PREFERENTIAL CONCENTRATION; BOUNDARY-LAYER; 2-PHASE FLOWS; SHEAR-LAYER; PIV; MICROBUBBLES; VELOCIMETRY; TURBULENCE AB With the prevalence of particle image velocimetry (PIV) as a quantitative tool for fluid mechanics diagnostics, its application for analyzing complicated multiphase flows has been steadily increasing over the last several decades. While the primary issue in using PIV for multiphase flows is in separating the information of the phases for independent analysis with a minimum of spurious "cross-talk," an equally crucial but often overlooked point is in the accurate quantitative measurement of the dispersed phase concentration. Accurate concentration measurement is important due to the fact that the dispersed phase is often heterogeneously distributed in both space and time, either due to a non-uniformity of the source of particulates (such as a spray nozzle or sediment boundary) or due to inertial migration of the particles even from originally homogeneous spatial distributions. In the current work, we examine the effects of light sheet profile distortion and attenuation by tracer seeding particles, as well as reflected light from local wall boundaries on the effective light sheet thickness. The effective thickness is critical for concentration measurements, as it dictates the dispersed phase detection volume. A direct calibration method is demonstrated to measure the effective light sheet thickness in a water/glass bead system, which shows that systematic bias errors on the order of 30% can result if the reflective bed condition is not accounted for, and the errors can be as high as 50% or more if a single-point measure of the sheet width is used. C1 [Kiger, Ken T.] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. [Knowles, Philip L.] NAVAIR, Appl Aerodynam & Store Separat Branch, Patuxent River, MD USA. RP Kiger, KT (reprint author), Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. EM philip.knowles@navy.mil; kkiger@umd.edu FU National Science Foundation [OCE-0351443]; Air Force Office of Scientific Research [FA95500810406] FX The authors would like to acknowledge generous funding by the National Science Foundation (OCE-0351443) and Air Force Office of Scientific Research (FA95500810406) in support of this work. NR 34 TC 1 Z9 1 U1 1 U2 16 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0723-4864 J9 EXP FLUIDS JI Exp. Fluids PD MAR PY 2012 VL 52 IS 3 BP 697 EP 708 DI 10.1007/s00348-011-1100-8 PG 12 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 899XB UT WOS:000300848900012 ER PT J AU Hallum-Montes, R D'Souza, R Tavarez, MI Manzanero, R Dann, GE Chun, HM Anastario, MP AF Hallum-Montes, Rachel D'Souza, Rohan Tavarez, Maria Isabel Manzanero, Russell Dann, Grace E. Chun, Helen M. Anastario, Michael P. TI Condom Use During Last Sexual Contact and Last 30 Days in Two Samples of Caribbean Military Personnel SO AMERICAN JOURNAL OF MENS HEALTH LA English DT Article DE risk behaviors; behavioral research; outcomes research; safe sex; quantitative research ID BORDER-CROSSING ZONES; RISK BEHAVIOR; HIV AB Condom use during last sexual contact is a survey measure that may be used to inform monitoring and evaluation indicators of recent condom use in populations at risk for HIV infection and other sexually transmitted infections, such as the uniformed services. The authors tested for differences in condom use measures that were fielded within separate Biological and Behavioral Surveillance Surveys conducted in the armed forces of two separate nations: the Dominican Republic and Belize. Both surveys included measures of condom use during last sexual contact with specified partners and both surveys included the Risk Behavior Assessment (RBA), which measures specific sexual acts and condom use frequency during a specified time period. In both samples, more than 40% of respondents who reported condom use during last sexual contact with a regular partner also reported engaging in unprotected sex when screened with the RBA. Furthermore, more than 60% of respondents who reported condom use during last sexual encounter with a commercial sex worker also reported engaging in unprotected sex when screened with the RBA. The results carry implications for monitoring and evaluation indicators of large-scale HIV prevention programs. The authors recommend that, when feasible, more in-depth instruments such as the RBA be considered to measure recent condom use in populations of uniformed services personnel. C1 [Hallum-Montes, Rachel; D'Souza, Rohan; Dann, Grace E.; Anastario, Michael P.] Cicatelli Associates Inc, New York, NY 10003 USA. [Tavarez, Maria Isabel] Armed Forces Dominican Republ, Santo Domingo, Dominican Rep. [Manzanero, Russell] Belize Def Force, Ladyville, Belize. [Chun, Helen M.] USN, Hlth Res Ctr, US Dept Def, San Diego, CA 92152 USA. RP Anastario, MP (reprint author), Cicatelli Associates Inc, 505 8th Ave,Suite 1600, New York, NY 10003 USA. EM manastario@gmail.com RI Ghartouchent, malek/B-9088-2012 NR 8 TC 1 Z9 1 U1 0 U2 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1557-9883 J9 AM J MENS HEALTH JI Am. J. Mens Health PD MAR PY 2012 VL 6 IS 2 BP 132 EP 135 DI 10.1177/1557988311418218 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 894NS UT WOS:000300434100004 PM 22105063 ER PT J AU Delorme, A Palmer, J Onton, J Oostenveld, R Makeig, S AF Delorme, Arnaud Palmer, Jason Onton, Julie Oostenveld, Robert Makeig, Scott TI Independent EEG Sources Are Dipolar SO PLOS ONE LA English DT Article ID BLIND SOURCE SEPARATION; EVENT-RELATED POTENTIALS; COMPONENT ANALYSIS; VISUAL-CORTEX; ELECTROENCEPHALOGRAPHIC DATA; NEURONAL AVALANCHES; WORKING-MEMORY; BRAIN SOURCES; RESPONSES; DYNAMICS AB Independent component analysis (ICA) and blind source separation (BSS) methods are increasingly used to separate individual brain and non-brain source signals mixed by volume conduction in electroencephalographic (EEG) and other electrophysiological recordings. We compared results of decomposing thirteen 71-channel human scalp EEG datasets by 22 ICA and BSS algorithms, assessing the pairwise mutual information (PMI) in scalp channel pairs, the remaining PMI in component pairs, the overall mutual information reduction (MIR) effected by each decomposition, and decomposition 'dipolarity' defined as the number of component scalp maps matching the projection of a single equivalent dipole with less than a given residual variance. The least well-performing algorithm was principal component analysis (PCA); best performing were AMICA and other likelihood/mutual information based ICA methods. Though these and other commonly-used decomposition methods returned many similar components, across 18 ICA/BSS algorithms mean dipolarity varied linearly with both MIR and with PMI remaining between the resulting component time courses, a result compatible with an interpretation of many maximally independent EEG components as being volume-conducted projections of partially-synchronous local cortical field activity within single compact cortical domains. To encourage further method comparisons, the data and software used to prepare the results have been made available (http://sccn.ucsd.edu/wiki/BSSComparison). C1 [Delorme, Arnaud; Palmer, Jason; Onton, Julie; Makeig, Scott] Univ Calif San Diego, Swartz Ctr Computat Neurosci, La Jolla, CA 92093 USA. [Delorme, Arnaud] Univ Toulouse 3, Ctr Rech Cerveau & Cognit, F-31062 Toulouse, France. [Oostenveld, Robert] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, NL-6525 ED Nijmegen, Netherlands. [Delorme, Arnaud] CNRS, CERCO, Toulouse, France. [Onton, Julie] Naval Hlth Res Ctr, San Diego, CA USA. RP Delorme, A (reprint author), Univ Calif San Diego, Swartz Ctr Computat Neurosci, La Jolla, CA 92093 USA. EM arno@ucsd.edu RI Delorme, Arnaud/F-8917-2011; Oostenveld, Robert/D-3259-2009 OI Oostenveld, Robert/0000-0002-1974-1293 FU Swartz Foundation (Old Field NY); National Institute of Mental Health USA [RO1-NS047293-01A1]; National Science Foundation USA [NSF IIS-0613595] FX This work was supported by a gift from the Swartz Foundation (Old Field NY) and by grants from the National Institute of Mental Health USA (RO1-NS047293-01A1) and the National Science Foundation USA (NSF IIS-0613595). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 56 TC 139 Z9 142 U1 0 U2 21 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 15 PY 2012 VL 7 IS 2 AR e30135 DI 10.1371/journal.pone.0030135 PG 14 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 925DP UT WOS:000302741300008 PM 22355308 ER PT J AU Joshi, A Haynes, ND Zelmon, DE Stafsudd, O Shori, R AF Joshi, A. Haynes, N. D. Zelmon, D. E. Stafsudd, O. Shori, R. TI Impurity concentration and temperature dependence of the refractive indices of Er3+ doped ceramic Y2O3 SO OPTICS EXPRESS LA English DT Article ID TRANSPARENT YTTRIA; LASER AB The refractive indices and thermo-optic coefficients for varying concentrations of Er3+ doped polycrystalline yttria were measured at a variety of wavelengths and temperatures. A Lorenz oscillator model was employed to model the room temperature indices and thermo-optic coefficients were calculated based on temperature dependent index measurements from 0.45 to 1.064 microns. Some consequences relating to thermal lensing are discussed. (C)2012 Optical Society of America C1 [Joshi, A.; Stafsudd, O.; Shori, R.] Univ Calif Los Angeles, Dept Elect Engn, Los Angeles, CA 90095 USA. [Haynes, N. D.; Zelmon, D. E.] USAF, Res Lab, AFRL RXPS, Wright Patterson AFB, OH 45433 USA. [Shori, R.] USN, Air Warfare Ctr, China Lake, CA USA. RP Joshi, A (reprint author), Univ Calif Los Angeles, Dept Elect Engn, Los Angeles, CA 90095 USA. EM david.zelmon@wpafb.af.mil NR 16 TC 4 Z9 4 U1 2 U2 14 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD FEB 13 PY 2012 VL 20 IS 4 BP 4428 EP 4435 DI 10.1364/OE.20.004428 PG 8 WC Optics SC Optics GA 902MH UT WOS:000301041900108 PM 22418202 ER PT J AU Foote, KG Hastings, MC Ketten, DR Lin, YT Reidenberg, JS Rye, K AF Foote, Kenneth G. Hastings, Mardi C. Ketten, Darlene R. Lin, Ying-Tsong Reidenberg, Joy S. Rye, Kent TI Sonar-induced pressure fields in a post-mortem common dolphin SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID MARINE MAMMALS; BEAKED-WHALES; BUBBLE-GROWTH; SOUND; CETACEANS; GAS AB Potential physical effects of sonar transmissions on marine mammals were investigated by measuring pressure fields induced in a 119-kg, 211-cm-long, young adult male common dolphin (Delphinus delphis) cadaver. The specimen was instrumented with tourmaline acoustic pressure gauges used as receiving sensors. Gauge implantation near critical tissues was guided by intraoperative, high-resolution, computerized tomography (CT) scanning. Instrumented structures included the melon, nares, ear, thoracic wall, lungs, epaxial muscle, and lower abdomen. The specimen was suspended from a frame equipped with a standard 50.8-mm-diameter spherical transducer used as the acoustic source and additional receiving sensors to monitor the transmitted and external, scattered field. Following immersion, the transducer transmitted pulsed sinusoidal signals at 5, 7, and 10 kHz. Quantitative internal pressure fields are reported for all cases except those in which the gauge failed or no received signal was detected. A full necropsy was performed immediately after the experiment to examine instrumented areas and all major organs. No lesions attributable to acoustic transmissions were found, consistent with the low source level and source-receiver distances. (C) 2012 Acoustical Society of America. [DOI: 10.11211.3675005] C1 [Foote, Kenneth G.; Ketten, Darlene R.] Woods Hole Oceanog Inst, Dept Biol, Woods Hole, MA 02543 USA. [Hastings, Mardi C.] Georgia Inst Technol, George W Woodruff Sch Mech Engn, Atlanta, GA 30332 USA. [Reidenberg, Joy S.] Mt Sinai Sch Med, Ctr Anat & Funct Morphol, New York, NY 10029 USA. [Rye, Kent] Naval Surface Warfare Ctr, Dept Navy, Carderock Div, Bethesda, MD 20817 USA. [Ketten, Darlene R.] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02114 USA. RP Foote, KG (reprint author), Woods Hole Oceanog Inst, Dept Biol, Woods Hole, MA 02543 USA. EM kfoote@whoi.edu OI Reidenberg, Joy/0000-0002-4180-7156 FU NOPP through ONR [N000140710992]; ONR [N000140811231] FX The contributions of J. A. Clark, deceased, are gratefully acknowledged. W. H. Lewis and other colleagues at NSWC are thanked for participating in the experiment. J. Arruda and S. Cramer are thanked for diverse contributions. M. Parmenter is thanked for editorial assistance. Work supported by NOPP through ONR Grant No. N000140710992. Work at CSI additionally supported by ONR Grant No. N000140811231. NR 38 TC 0 Z9 0 U1 2 U2 26 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD FEB PY 2012 VL 131 IS 2 BP 1595 EP 1604 DI 10.1121/1.3675005 PN 1 PG 10 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 895ID UT WOS:000300488800074 PM 22352529 ER PT J AU Wells, TS Ryan, MAK Jones, KA Hooper, TI Boyko, EJ Jacobson, IG Smith, TC Gackstetter, GD AF Wells, Timothy S. Ryan, Margaret A. K. Jones, Kelly A. Hooper, Tomoko I. Boyko, Edward J. Jacobson, Isabel G. Smith, Tyler C. Gackstetter, Gary D. TI A comparison of mental health outcomes in persons entering U.S. military service before and after September 11, 2001 SO JOURNAL OF TRAUMATIC STRESS LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; ADVERSE CHILDHOOD EXPERIENCES; US MILITARY; COMBAT DEPLOYMENT; MILLENNIUM COHORT; PRIMARY-CARE; ALCOHOL-USE; PRIME-MD; UTILITY; RISK AB It has been hypothesized that those who entered military service in the pre-September 11, 2001 era might have expectations incongruent with their subsequent experiences, increasing the risk for posttraumatic stress disorder (PTSD) or other mental disorders. A subset of Millennium Cohort Study participants who joined the military during 19951999 was selected and compared with a subset of members who joined the military in 2002 or later. Outcomes included new-onset symptoms of PTSD, depression, panic/anxiety, and alcohol-related problems. Multivariable methods adjusted for differences in demographic and military characteristics. More than 11,000 cohort members were included in the analyses. Those who entered service in the pre-September 11 era had lower odds of new-onset PTSD symptoms (odds ratio [OR] 0.74, 95% CI [0.59, 0.93]) compared with the post-September 11 cohort. There were no statistically significant differences in rates of new-onset symptoms of depression, panic/anxiety, or alcohol-related problems between the groups. The cohort who entered military service in the pre-September 11 era did not experience higher rates of new-onset mental health challenges compared with the cohort who entered service after September 11, 2001. Findings support the concept that the experience of war, and resulting psychological morbidity, is not a function of incongruent expectations. C1 [Wells, Timothy S.; Jones, Kelly A.; Jacobson, Isabel G.; Smith, Tyler C.] USN, Dept Deployment Hlth Res, Hlth Res Ctr, San Diego, CA 92106 USA. [Hooper, Tomoko I.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Boyko, Edward J.] Seattle Epidemiol Res & Informat Ctr, Dept Vet Affairs Puget Sound Hlth Care Syst, Seattle, WA USA. [Gackstetter, Gary D.] Analyt Serv Inc ANSER, Arlington, VA USA. RP Wells, TS (reprint author), USN, Dept Deployment Hlth Res, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. EM tim_wells@broadstripe.net RI Schueter, nicos/A-3625-2014 NR 32 TC 3 Z9 3 U1 1 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0894-9867 J9 J TRAUMA STRESS JI J. Trauma Stress PD FEB PY 2012 VL 25 IS 1 BP 17 EP 24 DI 10.1002/jts.21657 PG 8 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA 897VA UT WOS:000300685800004 PM 22354504 ER PT J AU Santomauro, M Masterson, J Marguet, C Crain, D AF Santomauro, Michael Masterson, James Marguet, Charles Crain, Donald TI DEMOGRAPHICS OF MEN RECEIVING VASECTOMIES IN THE US MILITARY 2000-2009 SO JOURNAL OF SEXUAL MEDICINE LA English DT Meeting Abstract C1 [Santomauro, Michael; Masterson, James; Marguet, Charles; Crain, Donald] NMCSD, San Diego, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1743-6095 J9 J SEX MED JI J. Sex. Med. PD FEB PY 2012 VL 9 SU 1 SI SI BP 42 EP 42 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA 886BW UT WOS:000299826700135 ER PT J AU Kasper, MR Blair, PJ Touch, S Sokhal, B Yasuda, CY Williams, M Richards, AL Burgess, TH Wierzba, TF Putnam, SD AF Kasper, Matthew R. Blair, Patrick J. Touch, Sok Sokhal, Buth Yasuda, Chadwick Y. Williams, Maya Richards, Allen L. Burgess, Timothy H. Wierzba, Thomas F. Putnam, Shannon D. TI Infectious Etiologies of Acute Febrile Illness among Patients Seeking Health Care in South-Central Cambodia SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID POLYMERASE-CHAIN-REACTION; SENTINEL SURVEILLANCE; IMMUNOGLOBULIN-M; UNKNOWN ORIGIN; SPOTTED-FEVER; DENGUE VIRUS; INFLUENZA; HEPATITIS; CHILDREN; EPIDEMIOLOGY AB The agents of human febrile illness can vary by region and country suggesting that diagnosis, treatment, and control programs need to be based on a methodical evaluation of area-specific etiologies. From December 2006 to December 2009, 9,997 individuals presenting with acute febrile illness at nine health care clinics in south-central Cambodia were enrolled in a study to elucidate the etiologies. Upon enrollment, respiratory specimens, whole blood, and serum were collected. Testing was performed for viral, bacterial, and parasitic pathogens. Etiologies were identified in 38.0% of patients. Influenza was the most frequent pathogen, followed by dengue, malaria, and bacterial pathogens isolated from blood culture. In addition, 3.5% of enrolled patients were infected with more than one pathogen. Our data provide the first systematic assessment of the etiologies of acute febrile illness in south-central Cambodia. Data from syndromic-based surveillance studies can help guide public health responses in developing nations. C1 [Kasper, Matthew R.] USN, Dept Bacteriol, Med Res Unit 6, Lima, Peru. [Blair, Patrick J.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Touch, Sok] Communicable Dis Control Dept, Phnom Penh, Cambodia. [Sokhal, Buth] Natl Inst Publ Hlth, Phnom Penh, Cambodia. [Yasuda, Chadwick Y.] USN, Med Res Unit 2, Phnom Penh, Cambodia. [Williams, Maya] USN, Dept Virol, Med Res Unit 6, Lima, Peru. [Richards, Allen L.] USN, Med Res Ctr, Silver Spring, MD USA. [Burgess, Timothy H.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Wierzba, Thomas F.] Int Vaccine Inst, Seoul, South Korea. RP Kasper, MR (reprint author), USN, Dept Bacteriol, Med Res Unit 6, Unit 3230,DPO,AA 34031, Lima, Peru. EM matthew.kasper@med.navy.mil; Patrick.blair@med.navy.mil; touch358@moh.gov.kh; buthsokhal@yahoo.com; chad@namru2.org.kh; Maya.williams@med.navy.mil; Allen.Richards@med.navy.mil; thurgess@idcrp.org; twierzba@ivi.int; Shan.putnam@med.navy.mil RI Valle, Ruben/A-7512-2013 FU U.S. Department of Defense Global Emerging Infectious Systems (DoD-GEIS); U.S. Department of State; U.S. Centers for Disease Control and Prevention FX This work was funded by the U.S. Department of Defense Global Emerging Infectious Systems (DoD-GEIS), the Biosecurity Engagement Program, U.S. Department of State, and the U.S. Centers for Disease Control and Prevention.; We are grateful to the clinicians and medical staff at the field sites in Cambodia for their assistance in enrolling and sampling patients. We thank laboratory personnel and field staff of NAMRU2-Phnom Penh for the conduct of work performed in support of this study. NR 32 TC 35 Z9 36 U1 1 U2 8 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 2012 VL 86 IS 2 BP 246 EP 253 DI 10.4269/ajtmh.2012.11-0409 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 886PQ UT WOS:000299866700014 PM 22302857 ER PT J AU Brasier, AR Ju, H Garcia, J Spratt, HM Victor, SS Forshey, BM Halsey, ES Comach, G Sierra, G Blair, PJ Rocha, C Morrison, AC Scott, TW Bazan, I Kochel, TJ AF Brasier, Allan R. Ju, Hyunsu Garcia, Josefina Spratt, Heidi M. Victor, Sundar S. Forshey, Brett M. Halsey, Eric S. Comach, Guillermo Sierra, Gloria Blair, Patrick J. Rocha, Claudio Morrison, Amy C. Scott, Thomas W. Bazan, Isabel Kochel, Tadeusz J. CA Venezuelan Dengue Fever Working TI A Three-Component Biomarker Panel for Prediction of Dengue Hemorrhagic Fever SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID DISEASE SEVERITY; INFECTION; VIRUS; CHILDREN; AMERICA; ILLNESS; CELLS AB Dengue virus infections are a major cause of morbidity in tropical countries. Early detection of dengue hemorrhagic fever (DHF) may help identify individuals that would benefit from intensive therapy. Predictive modeling was performed using 11 laboratory values of 51 individuals (38 DIP and 13 DHF) obtained on initial presentation using logistic regression. We produced a robust model with an area under the curve of 0.9615 that retained IL-10 levels, platelets, and lymphocytes as the major predictive features. A classification and regression tree was developed on these features that were 86% accurate on cross-validation. The IL-.10 levels and platelet counts were also identified as the most informative features associated with DHF using a Random Forest classifier. In the presence of polymerase chain reaction-proven acute dengue infections, we suggest a complete blood count and rapid measurement of IL-10 can assist in the triage of potential DHF cases for close follow-up or clinical intervention improving clinical outcome. C1 [Brasier, Allan R.] UTMB, Dept Internal Med, Galveston, TX 77555 USA. [Ju, Hyunsu; Spratt, Heidi M.] UTMB, Dept Prevent Med & Community Hlth, Galveston, TX 77555 USA. [Garcia, Josefina; Forshey, Brett M.; Halsey, Eric S.; Rocha, Claudio] US Naval Med Res Unit Six Unit 3230, Dpo Aa, FL USA. [Victor, Sundar S.] UTMB, Dept Biochem & Mol Biol, Galveston, TX 77555 USA. [Comach, Guillermo; Sierra, Gloria; Bazan, Isabel] Univ Carabobo, Inst Invest Biomed, Estado Aragua, Venezuela. [Blair, Patrick J.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Morrison, Amy C.; Scott, Thomas W.] Univ Calif Davis, Dept Entomol, Davis, CA 95616 USA. [Kochel, Tadeusz J.] USN, Viral & Rickettsial Dis Dept, Med Res Ctr, Silver Spring, MD USA. RP Brasier, AR (reprint author), UTMB, Dept Internal Med, MRB 8-128,301 Univ Blvd, Galveston, TX 77555 USA. EM arbrasie@utmb.edu; hyju@utmb.edu; Josefina.Garcia@med.navy.mil; hespratt@utmb.edu; ssvictor@utmb.edu; brett.forshey@gmail.com; Eric.halsey@med.navy.mil; gcomach@cantv.net; gmsierrac@yahoo.com; Patrick.Blair@med.navy.mil; claudio.rocha@med.navy.mil; amy.aegypti@gmail.com; twscott@ucdavis.edu; isabelbazana@gmail.com; Tad.kochel@med.navy.mil RI Valle, Ruben/A-7512-2013 FU NIH/NIAID Clinical Proteomics Center [HHSN272200800048C, 1U54RR02614 UTMB CTSA]; Military Infectious Diseases Research Program work unit [6000RAD1.S.B0302] FX This work was supported by the NIH/NIAID Clinical Proteomics Center, HHSN272200800048C (ARB), 1U54RR02614 UTMB CTSA (ARB) and the Military Infectious Diseases Research Program work unit 6000RAD1.S.B0302. NR 28 TC 26 Z9 27 U1 0 U2 4 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 2012 VL 86 IS 2 BP 341 EP 348 DI 10.4269/ajtmh.2012.11-0460 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 886PQ UT WOS:000299866700029 PM 22302872 ER PT J AU Chun, HM Roediger, MP Hullsiek, KH Thio, CL Agan, BK Bradley, WP Peel, SA Jagodzinski, LL Weintrob, AC Ganesan, A Wortmann, G Crum-Cianflone, NF Maguire, JD Landrum, ML AF Chun, Helen M. Roediger, Mollie P. Hullsiek, Katherine Huppler Thio, Chloe L. Agan, Brian K. Bradley, William P. Peel, Sheila A. Jagodzinski, Linda L. Weintrob, Amy C. Ganesan, Anuradha Wortmann, Glenn Crum-Cianflone, Nancy F. Maguire, Jason D. Landrum, Michael L. CA Infect Dis Clinical Res Program TI Hepatitis B Virus Coinfection Negatively Impacts HIV Outcomes in HIV Seroconverters SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; T-CELL RESPONSES; ACTIVE ANTIRETROVIRAL THERAPY; C-VIRUS; HOMOSEXUAL-MEN; RAPID PROGRESSION; INFECTED PATIENTS; NATURAL-HISTORY; AIDS; INDIVIDUALS AB Background. Understanding the impact of hepatitis B virus (HBV) in human immunodeficiency virus (HIV) coinfection has been limited by heterogeneity of HIV disease. We evaluated HBV coinfection and HIV-related disease progression in a cohort of HIV seroconverters. Methods. Participants with HIV diagnosis seroconversion window of < 3 years and serologically confirmed HBV infection (HB) status were classified at baseline into 4 HB groups. The risk of clinical AIDS/death in HIV seroconverters was calculated by HB status. Results. Of 2352 HIV seroconverters, 474 (20%) had resolved HB, 82 (3%) had isolated total antibody to hepatitis B core antigen (HBcAb), and 64 (3%) had chronic HB. Unadjusted rates (95% confidence intervals [CIs]) of clinical AIDS/death for the HB-negative, resolved HB, isolated HBcAb, and chronic HB groups were 2.43 (2.15-2.71); 3.27 (2.71-3.84); 3.75 (2.25-5.25); and 5.41 (3.41-7.42), respectively. The multivariable risk of clinical AIDS/death was significantly higher in the chronic HB group compared to the HB-negative group (hazard ratio [HR], 1.80; 95% CI, 1.20-2.69); while the HRs were increased but nonsignificant for those with resolved HB (HR, 1.17; 95% CI, .94-1.46) and isolated HBcAb (HR, 1.14; 95% CI, .75-1.75). Conclusions. HBV coinfection has a significant impact on HIV outcomes. The hazard for an AIDS or death event is almost double for those with chronic HB compared, with HIV-monoinfected persons. C1 [Chun, Helen M.; Roediger, Mollie P.; Hullsiek, Katherine Huppler; Agan, Brian K.; Bradley, William P.; Peel, Sheila A.; Jagodzinski, Linda L.; Weintrob, Amy C.; Ganesan, Anuradha; Wortmann, Glenn; Crum-Cianflone, Nancy F.; Maguire, Jason D.; Landrum, Michael L.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Div Infect Dis, Bethesda, MD USA. [Thio, Chloe L.] Johns Hopkins Univ, Div Infect Dis, Baltimore, MD USA. [Peel, Sheila A.; Jagodzinski, Linda L.] Walter Reed Army Inst Res, Div Retrovirol, Silver Spring, MD USA. [Chun, Helen M.] USN, Dept Def HIV AIDS Prevent Program, Hlth Res Ctr, San Diego, CA 92106 USA. [Crum-Cianflone, Nancy F.] USN, Infect Dis Clin, Med Ctr, San Diego, CA 92152 USA. [Roediger, Mollie P.; Hullsiek, Katherine Huppler] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Weintrob, Amy C.; Wortmann, Glenn] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. [Maguire, Jason D.] USN, Div Infect Dis, Med Ctr, Portsmouth, VA USA. [Landrum, Michael L.] San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX USA. RP Chun, HM (reprint author), USN, Dept Def HIV AIDS Prevent Program, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. EM helen.chun@med.navy.mil OI Eberly, Lynn/0000-0003-4763-330X; Agan, Brian/0000-0002-5114-1669 FU Department of Defense through Uniformed Services University of the Health Sciences; National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) [Y1-AI-5072] FX This work was supported by the Infectious Disease Clinical Research Program (IDCRP; www.idcrp.org), a Department of Defense program executed through Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072. The IDCRP reviewed the study design, collected the data and provided salary support to investigators (M. L. L., K. H. H., M. P. R., N. F. C., A. C. W., A. G., and B. K. A.). The analyses, conclusions, and decision to submit the manuscript are the independent work and decision of the authors. NR 43 TC 43 Z9 43 U1 0 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JAN 15 PY 2012 VL 205 IS 2 BP 185 EP 193 DI 10.1093/infdis/jir720 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 866NN UT WOS:000298387900006 PM 22147794 ER PT B AU Fu, TC Fullerton, AM Schleicher, CC AF Fu, Thomas C. Fullerton, Anne M. Schleicher, Christine C. GP ASME TI WAVEMAKER LIMITATIONS AND DIFFICULTIES IN MODEL TESTING OF SMALL HIGH SPEED CRAFT SO PROCEEDINGS OF THE ASME 31ST INTERNATIONAL CONFERENCE ON OCEAN, OFFSHORE AND ARCTIC ENGINEERING, 2012, VOL 4 LA English DT Proceedings Paper CT 31st ASME International Conference on Ocean, Offshore and Arctic Engineering CY JUL 01-06, 2012 CL Rio de Janeiro, BRAZIL SP Petrobras, ASME, Ocean Offshore & Arct Engn Div AB Model testing of marine platforms has always focused on preserving geometric similitude and Froude number. While Froude scaling does provide a good approximation to true dynamic similitude, there are viscous effects which are not scaled. Additionally, the dynamic testing of small high speed marine craft presents difficulties due to their small size, so while one would prefer to minimize these effects by testing large models, model basin characteristics limit the physical size of the models that can be tested. These issues as they relate to model testing, including sea state scaling and scale effects, are discussed. C1 [Fu, Thomas C.; Fullerton, Anne M.; Schleicher, Christine C.] Naval Surface Warfare Ctr, Carderock Div, West Bethesda, MD USA. RP Fu, TC (reprint author), Naval Surface Warfare Ctr, Carderock Div, West Bethesda, MD USA. NR 11 TC 0 Z9 0 U1 1 U2 2 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4491-5 PY 2012 BP 333 EP 340 PG 8 WC Engineering, Ocean; Engineering, Mechanical SC Engineering GA BGZ17 UT WOS:000324655900039 ER PT B AU Jiang, M Lien, V Lesar, D Engle, A Lewis, R AF Jiang, Minyee Lien, Van Lesar, Douglas Engle, Allen Lewis, Richard GP ASME TI A Validation of Various Codes Using Hydrodynamic Wedge Impact Data SO PROCEEDINGS OF THE ASME 31ST INTERNATIONAL CONFERENCE ON OCEAN, OFFSHORE AND ARCTIC ENGINEERING, 2012, VOL 4 LA English DT Proceedings Paper CT 31st ASME International Conference on Ocean, Offshore and Arctic Engineering CY JUL 01-06, 2012 CL Rio de Janeiro, BRAZIL SP Petrobras, ASME, Ocean Offshore & Arct Engn Div AB It is well known that slamming and whipping can significantly contribute to a ship's structural loading which can severely impact a ship's operational safety. Therefore, a method of predicting severe transient structural loads is needed, especially for the design of future high-speed patrol boats and high-speed ferries. A number of computational fluid dynamics (CFD) codes have demonstrated the ability to cope with complex body shapes and to numerically capture the nonlinear effect of hydro-elasticity. However, validation is scarce both due to a lack of experimental data and the computational intensity of the problem. This paper describes a validation study of a Reynolds averaged Navier-Stokes (RANS) code (STAR-CCM+) and a Lagrangian-Eulerian fluid structure interaction (FSI) code (DYSMAS) using 10 degree wedge drop test experimental data obtained at the Naval Warfare Center, Carderock Division, December 2010. C1 [Jiang, Minyee] US Navy, Hydromech Dept, Naval Surface Warfare Ctr, Carderock Div NSWCCD, West Bethesda, MD USA. RP Jiang, M (reprint author), US Navy, Hydromech Dept, Naval Surface Warfare Ctr, Carderock Div NSWCCD, West Bethesda, MD USA. NR 11 TC 1 Z9 1 U1 0 U2 1 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4491-5 PY 2012 BP 743 EP 752 PG 10 WC Engineering, Ocean; Engineering, Mechanical SC Engineering GA BGZ17 UT WOS:000324655900080 ER PT B AU Minnick, L Bassler, C Percival, S AF Minnick, Lisa Bassler, Christopher Percival, Scott GP ASME TI ANALYSIS OF THE PHYSICS OF BILGE KEEL VORTEX GENERATION SO PROCEEDINGS OF THE ASME 31ST INTERNATIONAL CONFERENCE ON OCEAN, OFFSHORE AND ARCTIC ENGINEERING, 2012, VOL 4 LA English DT Proceedings Paper CT 31st ASME International Conference on Ocean, Offshore and Arctic Engineering CY JUL 01-06, 2012 CL Rio de Janeiro, BRAZIL SP Petrobras, ASME, Ocean Offshore & Arct Engn Div ID ROLL AB A 2D forced roll oscillation experiment was performed to examine and characterize the physics of vortex generation from ship bilge keels. Measurements included ship model motions, normal force on the bilge keels, and flow field visualizations using Particle Image Velocimetry (PIV). Data was collected for a range of roll oscillation amplitudes, including large amplitudes where the bilge keels interacted with the free surface and for three roll oscillation frequencies. This paper presents analysis and description of the observed phenomena, and examines whether a functional relationship can be established between the force measured on the bilge keel and the flow field generated by the bilge keel. A qualitative discussion of the observed flow characteristics, including the vortex generation at the tip of the bilge keel, detachment, and interaction with the free-surface, is presented. In addition, the circulation in front and behind the bilge keel was calculated, analyzed, and compared to the measured bilge keel force. The analysis conducted was intended to provide improved understanding of the phenomena which occur during bilge keel vortex generation and aid in the development of improved roll damping and bilge keel force models for the prediction of ship motions. C1 [Minnick, Lisa; Bassler, Christopher; Percival, Scott] Naval Surface Warfare Ctr, Carderock Div, West Bethesda, MD USA. RP Minnick, L (reprint author), Naval Surface Warfare Ctr, Carderock Div, West Bethesda, MD USA. NR 25 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4491-5 PY 2012 BP 761 EP 779 PG 19 WC Engineering, Ocean; Engineering, Mechanical SC Engineering GA BGZ17 UT WOS:000324655900082 ER PT S AU Lee, YT Cooper, P AF Lee, Yu-Tai Cooper, Paul GP ASME TI A MULTI-OBJECTIVE OPTIMIZATION FOR A CENTRIFUGAL FAN IMPELLER SO PROCEEDINGS OF THE ASME FLUIDS ENGINEERING DIVISION SUMMER MEETING, 2012, VOL 1, PTS A AND B, SYMPOSIA SE ASME Fluids Engineering Division Summer Meeting LA English DT Proceedings Paper CT ASME Fluids Engineering Division Summer Meeting (FEDSM) CY JUL 08-12, 2012 CL Rio Grande, PR SP ASME, Fluids Engn Div ID DESIGN AB A reduced-order flow analysis method is developed to predict impeller flow field and impeller performance characteristics for a high-specific-speed centrifugal fan attached with a double-discharge volute. The method is validated by comparing its performance prediction for a baseline fan with measurements. The flow analysis calculation not only predicts impeller flow field, but also generates impeller configurations based on given impeller design parameters. A multi-objective genetic algorithm is also developed and coupled with the reduced-order flow analysis to perform a direct online search of the nominal (deterministic) optimum impeller design envelope. An existing fan serving as the baseline fan was reverse engineered to regenerate its geometry using the current method. The optimization calculations were used to explore design variables including blade inlet and outlet angles, shroud angle and blade leading-edge span as 2, 3 and 4-variable design calculations. The 2-variable prediction concludes that the fan is limited in its performance improvement if only the blade shape is changed, which agrees with early CFD prediction results of the baseline fan. Comparing 3 and 4-variable predictions with the 2-variable predictions, larger ranges of improvement in fan performance are feasible by only considering fan aerodynamics. Furthermore the conflicting nature of design variables with regard to the fan performance improvement is also demonstrated by the prediction results. C1 [Lee, Yu-Tai] Naval Surface Warfare Ctr, Carderock Div, West Bethesda, MD USA. RP Lee, YT (reprint author), Naval Surface Warfare Ctr, Carderock Div, West Bethesda, MD USA. EM yu.lee@navy.mil; paul.cooper@verizon.net NR 17 TC 1 Z9 1 U1 0 U2 1 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA SN 1093-4928 BN 978-0-7918-4475-5 J9 ASME FLUID ENG DIV PY 2012 BP 153 EP 165 PG 13 WC Engineering, Mechanical; Transportation Science & Technology SC Engineering; Transportation GA BGX48 UT WOS:000324506700016 ER PT B AU Drazen, D Terrill, E Walker, D Hazard, J Cook, T Scott, S AF Drazen, David Terrill, Eric Walker, Don Hazard, Joel Cook, Tom Scott, Shannon GP ASME TI FULL-SCALE MEASUREMENTS OF WAVE IMPACT LOADING ON A FLAT PLATE SO PROCEEDINGS OF THE ASME 31ST INTERNATIONAL CONFERENCE ON OCEAN, OFFSHORE AND ARTIC ENGINEERING, VOL 1 LA English DT Proceedings Paper CT 31st ASME International Conference on Ocean, Offshore and Arctic Engineering CY JUL 01-06, 2012 CL Rio de Janeiro, BRAZIL SP Petrobras, ASME, Ocean Offshore & Arct Engn Div AB Full scale measurements of wave impact loads and their statistics in real sea states are desirable for validation of numerical simulations and for application to marine engineering design problems. Measuring and/or estimating wave forces on flat plates are especially problematic due to statistics of large waves in a given sea state, the intermittent statistics of wave breaking, the sensitivity of the loading relative to the phase of the incoming wave and scaling issues when translating from model scale data to full-scale. To increase our understanding of wave hydrodynamic pressures on a flat plate, an instrumented plate was deployed from the Scripps Institution of Oceanography's research pier. The instrumented plate is exposed to a wide range of wave conditions with H-s ranging from 3-4 m in the winter and with Hs in the 1-2 m range in the summer The instrumented flat plate is composed of three discrete modules containing 6 pressure gages. Data are being collected over a extended period, nominally 12 months, to characterize extreme value distributions due to wave impact loading. C1 [Drazen, David; Walker, Don] Naval Surface Warfare Ctr, Carderock Div, West Bethesda, MD USA. RP Drazen, D (reprint author), Naval Surface Warfare Ctr, Carderock Div, West Bethesda, MD USA. NR 14 TC 1 Z9 1 U1 0 U2 1 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4488-5 PY 2012 BP 449 EP 458 PG 10 WC Engineering, Ocean; Engineering, Mechanical SC Engineering GA BGY22 UT WOS:000324565000047 ER PT J AU Macera, CA Aralis, HJ MacGregor, AJ Rauh, MJ Galarneau, MR AF Macera, Caroline A. Aralis, Hilary J. MacGregor, Andrew J. Rauh, Mitchell J. Galarneau, Michael R. TI Postdeployment symptom changes and traumatic brain injury and/or posttraumatic stress disorder in men SO JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT LA English DT Article DE blasts; deployment; males; military; odds ratio; percent change; Post-Deployment Health Assessment; posttraumatic stress disorder; symptoms; traumatic brain injury ID HEALTH PROBLEMS; IRAQ; MILITARY; AFGHANISTAN; DEPLOYMENT; VETERANS; CARE; CHALLENGES; OUTCOMES; PROGRAM AB In Operation Iraqi Freedom and Operation Enduring Freedom, blast-related injuries associated with combat are frequent and can result in traumatic brain injury (TBI) symptoms that may be difficult to distinguish from psychological problems. Using data from the Post-Deployment Health Assessment and Reassessment, we identified 12,046 male U.S. Navy sailors and Marines with reported combat exposure from 2008 to 2009. Symptoms potentially associated with blast-related TBI and posttraumatic stress disorder (PTSD) that were reported immediately after deployment were compared with symptoms present several months later. Our study supports others that have found that subjects with blast-related injuries may experience the development or worsening of symptoms during the months following deployment. Additionally, our study found that those who screened positive for PTSD and TBI formed a unique group, with the presence of TBI exacerbating development of PTSD symptoms at reassessment. Providers should recognize the late development of symptoms, consider the possibility of comorbidity, and be prepared to treat multiple symptoms rather than a specific diagnostic category. C1 [Macera, Caroline A.; Aralis, Hilary J.; Rauh, Mitchell J.] USN, Hlth Res Ctr, Warfighter Performance Dept, San Diego, CA 92106 USA. [MacGregor, Andrew J.; Galarneau, Michael R.] USN, Hlth Res Ctr, Med Modeling Simulat & Mission Support Dept, San Diego, CA 92106 USA. RP Aralis, HJ (reprint author), USN, Hlth Res Ctr, Warfighter Performance Dept, 140 Sylvester Rd, San Diego, CA 92106 USA. EM Hilary.Aralis@gmail.com RI Schueter, nicos/A-3625-2014 FU U.S. Navy Bureau of Medicine and Surgery [60818] FX This material was based on work supported by the U.S. Navy Bureau of Medicine and Surgery, under Work Unit No. 60818. NR 33 TC 12 Z9 12 U1 2 U2 6 PU JOURNAL REHAB RES & DEV PI BALTIMORE PA DEPT OF VETERANS AFFAIRS REHABIL RES & DEVELOP CTR 103 SOUTH GAY STREET, BALTIMORE, MD 21202-4051 USA SN 0748-7711 J9 J REHABIL RES DEV JI J. Rehabil. Res. Dev. PY 2012 VL 49 IS 8 BP 1197 EP 1208 DI 10.1682/JRRD.2011.07.0131 PG 12 WC Rehabilitation SC Rehabilitation GA 149FA UT WOS:000319303200007 PM 23341312 ER PT B AU Mullen, L Cochenour, B AF Mullen, Linda Cochenour, Brandon GP IEEE TI Communication over Lasers in Ocean Research (COLOR) Bringing Navy Research to the Classroom SO 2012 OCEANS LA English DT Proceedings Paper CT MTS/IEEE Oceans Conference CY OCT 14-19, 2012 CL Virginia Beach, VA SP IEEE, Marine Technol Soc (MTS), IEEE OES (IEEE/OES) DE STEM; laser; communication; scattering; absorption AB Scientists and engineers in the Electro-Optics and Special Mission Sensors division at NAVAIR have developed a hands-on activity, Communication over Lasers in Ocean Research (COLOR), to bring their Navy research to K-12 classrooms. This activity was created in response to the Navy's interest in increasing the number of US students pursuing careers in Science Technology Engineering and Math (STEM) disciplines. The COLOR activity provides a way for Navy scientists and K-12 educators to excite students about lasers, optics, and how the Navy uses these tools to complete critical missions. The following paper details the various modules of the COLOR activity and how they are used to teach students and faculty about light and how it can be used to see and communicate in the underwater environment. C1 [Mullen, Linda; Cochenour, Brandon] NAVAIR, EO & Special Mission Sensors Div, Patuxent River, MD USA. RP Mullen, L (reprint author), NAVAIR, EO & Special Mission Sensors Div, Patuxent River, MD USA. EM linda.mullen@navy.mil NR 2 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4673-0829-8 PY 2012 PG 4 WC Engineering, Multidisciplinary; Telecommunications SC Engineering; Telecommunications GA BDW56 UT WOS:000315350300110 ER PT B AU Perez, P Jemison, WD Mullen, L Laux, A AF Perez, Paul Jemison, William D. Mullen, Linda Laux, Alan GP IEEE TI Techniques to enhance the performance of hybrid lidar-radar ranging systems SO 2012 OCEANS LA English DT Proceedings Paper CT MTS/IEEE Oceans Conference CY OCT 14-19, 2012 CL Virginia Beach, VA SP IEEE, Marine Technol Soc, IEEE Ocean Engn Soc DE underwater; optical ranging; scattering AB Hybrid lidar-radar uses a combination of lidar and radar techniques to enhance underwater detection, ranging, and imaging. In turbid water, the lidar return signal includes a significant amount of backscatter in addition to the object-reflected light. System performance is highly limited by the backscatter which results from volumetric scattering of the transmitted light signal off the particulates existing in the water channel. A new backscatter reduction techniqu based on spatial frequency filtering will be discussed. The spatia filter algorithm leverages radar techniques developed to enhance through the wall imaging (TTWI) performance. Algorithm validation via experimental data is provided. C1 [Perez, Paul] Clarkson Univ, Dept Phys, Potsdam, NY 13699 USA. [Jemison, William D.] Clarkson Univ, Dept Elect & Comp Engn, Potsdam, NY 13699 USA. [Mullen, Linda; Laux, Alan] NAVAIR, EO & Special Mission Sensors Div, Columbia, MD USA. RP Perez, P (reprint author), Clarkson Univ, Dept Phys, Potsdam, NY 13699 USA. EM perezpd@clarkson.edu NR 4 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4673-0829-8; 978-1-4673-0830-4 PY 2012 PG 6 WC Engineering, Multidisciplinary; Telecommunications SC Engineering; Telecommunications GA BDW56 UT WOS:000315350300181 ER PT J AU Jenn, D Ton, C AF Jenn, David Ton, Cuong TI Wind Turbine Radar Cross Section SO INTERNATIONAL JOURNAL OF ANTENNAS AND PROPAGATION LA English DT Article AB The radar cross section (RCS) of a wind turbine is a figure of merit for assessing its effect on the performance of electronic systems. In this paper, the fundamental equations for estimating the wind turbine clutter signal in radar and communication systems are presented. Methods of RCS prediction are summarized, citing their advantages and disadvantages. Bistatic and monostatic RCS patterns for two wind turbine configurations, a horizontal axis three-blade design and a vertical axis helical design, are shown. The unique electromagnetic scattering features, the effect of materials, and methods of mitigating wind turbine clutter are also discussed. C1 [Jenn, David] USN, Postgrad Sch, Monterey, CA 93943 USA. [Ton, Cuong] USN, Weap Div, Air Warfare Ctr, Point Mugu Nawc, CA 93042 USA. RP Jenn, D (reprint author), USN, Postgrad Sch, 833 Dyer Rd,Room 437, Monterey, CA 93943 USA. EM jenn@nps.edu NR 27 TC 9 Z9 9 U1 0 U2 11 PU HINDAWI PUBLISHING CORPORATION PI NEW YORK PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA SN 1687-5869 J9 INT J ANTENN PROPAG JI Int. J. Antennas Propag. PY 2012 AR 252689 DI 10.1155/2012/252689 PG 14 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 069OM UT WOS:000313446000001 ER PT S AU Prel, F Moreau, L Lantagne, S Bullis, RD Roy, C Vallieres, C Levesque, L AF Prel, Florent Moreau, Louis Lantagne, Stephane Bullis, Ritchie D. Roy, Claude Vallieres, Christian Levesque, Luc BE Kamerman, GW Steinvall, O Lewis, KL Hollins, RC Merlet, TJ Gruneisen, MT Dusek, M Rarity, JG Bishop, GJ Gonglewski, J TI Standoff Aircraft IR Characterization with ABB dual-band Hyper Spectral Imager SO ELECTRO-OPTICAL REMOTE SENSING, PHOTONIC TECHNOLOGIES, AND APPLICATIONS VI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Electro-Optical Remote Sensing, Photonic Technologies, and Applications VI CY SEP 24-26, 2012 CL Edinburgh, SCOTLAND SP SPIE, SELEX GALILEO, THALES AB Remote sensing infrared characterization of rapidly evolving events generally involves the combination of a spectro-radiometer and infrared camera(s) as separated instruments. Time synchronization, spatial coregistration, consistent radiometric calibration and managing several systems are important challenges to overcome; they complicate the target infrared characterization data processing and increase the sources of errors affecting the final radiometric accuracy. MR-i is a dual-band Hyperspectal imaging spectro-radiometer, that combines two 256 x 256 pixels infrared cameras and an infrared spectro-radiometer into one single instrument. This field instrument generates spectral datacubes in the MWIR and LWIR. It is designed to acquire the spectral signatures of rapidly evolving events. The design is modular. The spectrometer has two output ports configured with two simultaneously operated cameras to either widen the spectral coverage or to increase the dynamic range of the measured amplitudes. Various telescope options are available for the input port. Recent platform developments and field trial measurements performances will be presented for a system configuration dedicated to the characterization of airborne targets. C1 [Prel, Florent; Moreau, Louis; Lantagne, Stephane; Roy, Claude; Vallieres, Christian; Levesque, Luc] ABB, Remote Sensing Grp, 585 Charest Blvd E,Suite 300, Quebec City, PQ G1K 9H4, Canada. [Bullis, Ritchie D.] Patuxent River Infrared Signature Measurement P, Atlant Test Ranges Aircraft Signature Avion Measu, NAVAIR, Patuxent River, MD 20670 USA. RP Prel, F (reprint author), ABB, Remote Sensing Grp, 585 Charest Blvd E,Suite 300, Quebec City, PQ G1K 9H4, Canada. EM florent.m.prel@ca.abb.com NR 5 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-9283-8 J9 PROC SPIE PY 2012 VL 8542 AR 85422A DI 10.1117/12.974775 PG 12 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA BDA59 UT WOS:000312346500061 ER PT S AU Tian, YD Narasimhan, SG Vannevel, AJ AF Tian, Yuandong Narasimhan, Srinivasa G. Vannevel, Alan J. GP IEEE TI Depth from Optical Turbulence SO 2012 IEEE CONFERENCE ON COMPUTER VISION AND PATTERN RECOGNITION (CVPR) SE IEEE Conference on Computer Vision and Pattern Recognition LA English DT Proceedings Paper CT IEEE Conference on Computer Vision and Pattern Recognition (CVPR) CY JUN 16-21, 2012 CL Providence, RI SP IEEE AB Turbulence near hot surfaces such as desert terrains and roads during the summer, causes shimmering, distortion and blurring in images. While recent works have focused on image restoration, this paper explores what information about the scene can be extracted from the distortion caused by turbulence. Based on the physical model of wave propagation, we first study the relationship between the scene depth and the amount of distortion caused by homogenous turbulence. We then extend this relationship to more practical scenarios such as finite extent and height-varying turbulence, and present simple algorithms to estimate depth ordering, depth discontinuity and relative depth, from a sequence of short exposure images. In the case of general non-homogenous turbulence, we show that a statistical property of turbulence can be used to improve long-range structure-from-motion (or stereo). We demonstrate the accuracy of our methods in both laboratory and outdoor settings and conclude that turbulence (when present) can be a strong and useful depth cue. C1 [Tian, Yuandong; Narasimhan, Srinivasa G.] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA. [Vannevel, Alan J.] US Naval, Air Warfare Ctr, China Lake, CA USA. RP Tian, YD (reprint author), Carnegie Mellon Univ, Pittsburgh, PA 15213 USA. EM yuandong@cs.cmu.edu; srinivas@cs.cmu.edu; alan.vannevel@navy.mil NR 25 TC 2 Z9 2 U1 1 U2 7 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1063-6919 BN 978-1-4673-1228-8 J9 PROC CVPR IEEE PY 2012 BP 246 EP 253 PG 8 WC Computer Science, Artificial Intelligence; Computer Science, Interdisciplinary Applications; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BBZ37 UT WOS:000309166200032 ER PT S AU Strand, TE Ennis, MJ AF Strand, Trevor E. Ennis, Maj John GP IEEE TI MV-22B High Density Altitude Handling Qualities SO 2012 IEEE AEROSPACE CONFERENCE SE IEEE Aerospace Conference Proceedings LA English DT Proceedings Paper CT IEEE Aerospace Conference CY MAR 03-10, 2012 CL Big Sky, MT SP IEEE, AIAA, Phmsoc, AESS AB All rotary wing aircraft suffer from degraded handling qualities while operating at high density altitudes (DA). (1 2 3) It was predicted that the V-22 Osprey would also suffer degraded flying qualities at high DA; however no testing in the low airspeed regime had been conducted above 6000 ft DA, and predictions and simulation were unreliable at high rotor thrust coefficients. To expand the aircraft operating envelope, and evaluate the unique handling qualities of a tilt rotor, a test program was conducted to evaluate aircraft operational effectiveness specifically in the low airspeed regime (below 50 knots). Flight control frequency response and bandwidth were evaluated in all axes. Paced critical azimuth was conducted to evaluate trim conditions and control margins. Multi-axis inputs were evaluated to determine attitude response. Mission Task Elements (MTE's) were evaluated to characterize operational effectiveness, and validated current tilt rotor techniques and procedures. This paper presents the test method, scope, and planning efforts, presents results and conclusions, and also identifies recommendations and lessons learned from the evaluation. C1 [Strand, Trevor E.] Naval Air Syst Command, ISEET Detachment, Hangar 109,RM 255,22347 Cedar Point Rd,Unit 6, Patuxent River, MD 20670 USA. [Ennis, Maj John] USMC, Dept Navy, AITEVRON 21 HX-21, Patuxent River, MD 20670 USA. RP Strand, TE (reprint author), Naval Air Syst Command, ISEET Detachment, Hangar 109,RM 255,22347 Cedar Point Rd,Unit 6, Patuxent River, MD 20670 USA. EM trevor.strand@navy.mil; john.ennis@navy.mil NR 0 TC 0 Z9 0 U1 1 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1095-323X BN 978-1-4577-0557-1 J9 AEROSP CONF PROC PY 2012 PG 7 WC Engineering, Aerospace SC Engineering GA BBZ12 UT WOS:000309105303030 ER PT J AU Boseman, MF Kwon, YW Loup, DC Rasmussen, EA AF Boseman, M. F. Kwon, Y. W. Loup, D. C. Rasmussen, E. A. TI Interface fracture of hybrid joint of glass-/steel-fiber composite SO ENGINEERING COMPUTATIONS LA English DT Article DE Composite materials; Joining materials; Joining processes; Steels; Steel fiber; Butt joint; Overlap joint; Virtual crack closure; Hybrid ID CARBON NANOTUBE REINFORCEMENT; CRACK-PROPAGATION; BONDED JOINTS; STRENGTH AB Purpose - In order to connect a fiberglass composite structure to a steel structure, a hybrid composite made of glass and steel fibers has been studied. The hybrid composite has one end section with all glass fibers and the opposite end section with all steel fibers. As a result, it contains a transition section in the middle of the hybrid composite changing from glass fibers to steel fibers. The purpose of this paper is to examine interface strength at the glass to steel fiber transition section, in order to evaluate the effectiveness of the hybrid composite as a joining technique between a polymer composite structure and a metallic structure. Design/methodology/approach - The present micromechanical study considers two types of glass to steel fiber joints: butt and overlap joints. For the butt joint, the end shape of the steel fiber is also modified to determine its effect on interface strength. The interface strength is predicted numerically based on the virtual crack closure technique to determine which joint is the strongest under various loading conditions such as tension, shear and bending. Numerical models include resin layers discretely. A virtual crack is considered inside the resin, at the resin/glass-layer interface, and at the resin/steel-layer interface. The crack is located at the critical regions of the joints. Findings - Overall, the butt joint is stronger than the overlap joint regardless of loading types and directions. Furthermore, modification of an end shape of the middle fiber layers in the butt joint shifts the critical failure location. Originality/value - The paper describes one of a few studies which investigated the interface strength of the hybrid joint made of fiberglass and steel-fiber composites. This joint is important to connect a polymeric composite structure to a metallic structure without using conventional mechanical joints. C1 [Boseman, M. F.; Kwon, Y. W.] Naval Postgrad Sch, Mech & Astronaut Engn Dept, Monterey, CA USA. [Loup, D. C.; Rasmussen, E. A.] Naval Surface Warfare Ctr, Struct & Composite Div, Bethesda, MD USA. RP Boseman, MF (reprint author), Naval Postgrad Sch, Mech & Astronaut Engn Dept, Monterey, CA USA. NR 26 TC 1 Z9 1 U1 0 U2 9 PU EMERALD GROUP PUBLISHING LIMITED PI BINGLEY PA HOWARD HOUSE, WAGON LANE, BINGLEY BD16 1WA, W YORKSHIRE, ENGLAND SN 0264-4401 J9 ENG COMPUTATION JI Eng. Comput. PY 2012 VL 29 IS 5-6 BP 504 EP 527 DI 10.1108/02644401211235861 PG 24 WC Computer Science, Interdisciplinary Applications; Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications; Mechanics SC Computer Science; Engineering; Mathematics; Mechanics GA 013TK UT WOS:000309328600003 ER PT J AU Hegedus, CR Spadafora, SJ Eng, AT Pulley, DF Hirst, DJ AF Hegedus, Charles R. Spadafora, Stephen J. Eng, Anthony T. Pulley, David F. Hirst, Donald J. BE Koleske, JV TI Aerospace and Aircraft Coatings SO PAINT AND COATING TESTING MANUAL: FIFTEENTH EDITION OF THE GARDNER-SWARD HANDBOOK SE ASTM International Manual Series LA English DT Article; Book Chapter C1 [Hegedus, Charles R.] Air Prod & Chem Inc, Allentown, PA 18195 USA. [Spadafora, Stephen J.] USN, NAVAIR, Mat Engn Div, Air Syst Command, Patuxent River, MD 20670 USA. [Eng, Anthony T.] USN, Ctr Surface Warfare, Carderock Div, Philadelphia, PA 19112 USA. RP Hegedus, CR (reprint author), Air Prod & Chem Inc, 7201 Hamilton Blvd, Allentown, PA 18195 USA. NR 17 TC 0 Z9 0 U1 0 U2 1 PU ASTM INTERNATIONAL PI WEST CONSHOHOCKEN PA 100 BARR HARBOR DRIVE, PO BOX C700, WEST CONSHOHOCKEN, PA 19428-2959 USA BN 978-0-8031-7017-9 J9 ASTM INT MAN SER PY 2012 IS MNL17 BP 739 EP 750 PG 12 WC Materials Science, Characterization & Testing; Materials Science, Coatings & Films SC Materials Science GA BAL05 UT WOS:000304464700061 ER PT S AU Laux, A Mullen, L Perez, P Zege, E AF Laux, Alan Mullen, Linda Perez, Paul Zege, Eleonora BE Hou, WW Arnone, R TI Underwater laser range finder SO OCEAN SENSING AND MONITORING IV SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Ocean Sensing and Monitoring IV CY APR 24-26, 2012 CL Baltimore, MD SP SPIE DE underwater; laser; modulation; range ID SEA-WATER; FREQUENCY; IMAGER AB The conventional method used to detect the range to an underwater object is by sending and receiving some form of acoustic energy. However, acoustic systems have limitations in the range resolution and accuracy they can provide under certain conditions. The potential benefits of a laser-based range finder include high-directionality and covertness, speed of response, and the potential for high-precision, range accuracy. These benefits have been exploited in the above-water environment where kilometer propagation ranges are achieved with sub-meter range precision. The challenge in using optical techniques in the underwater environment is overcoming the exponential loss due to scattering and absorption. While absorption extinguishes photons, scattering redistributes the light and produces a 'clutter' signal component from the surrounding water environment. Optical modulation techniques using compact laser diode sources are being investigated to help suppress this 'clutter' and provide accurate target range information in a wide range of underwater environments. To complement the experimental efforts, a theoretical model has been developed to help optimize the system parameters and test the performance of various configurations as a function of different water optical properties. Results from laboratory water tank experiments will be discussed and compared with model predictions. C1 [Laux, Alan; Mullen, Linda] USN, Air Syst Command, NAVAIR, Electroopt & Special Mission Sensors Div, Patuxent River, MD 20670 USA. RP Laux, A (reprint author), USN, Air Syst Command, NAVAIR, Electroopt & Special Mission Sensors Div, Patuxent River, MD 20670 USA. NR 12 TC 1 Z9 1 U1 3 U2 9 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-9050-6 J9 PROC SPIE PY 2012 VL 8372 AR 83721B DI 10.1117/12.919280 PG 11 WC Remote Sensing; Optics SC Remote Sensing; Optics GA BBD52 UT WOS:000306562700037 ER PT J AU Davis, MC Groshens, TJ AF Davis, Matthew C. Groshens, Thomas J. TI 6-DIALKYLAMINOBENZIMIDAZOLE NONLINEAR OPTICAL DYES SO SYNTHETIC COMMUNICATIONS LA English DT Article DE Benzimidazole; chromophore; nonlinear optical ID FACTORS CONTROLLING REGIOSELECTIVITY; ALPHA-ENONES; BENZIMIDAZOLE; DERIVATIVES; INHIBITORS; ADDITIONS; NITRILES; DESIGN; AGENTS AB A new 6-dialkylaminobenzimidazole nonlinear optical dye was synthesized in eight linear steps with an overall yield of 16%. C1 [Davis, Matthew C.; Groshens, Thomas J.] USN, Air Warfare Ctr, Michelson Lab, Chem & Mat Div, China Lake, CA 93555 USA. RP Davis, MC (reprint author), USN, Air Warfare Ctr, Michelson Lab, Chem & Mat Div, China Lake, CA 93555 USA. EM matthew.davis@navy.mil NR 26 TC 1 Z9 1 U1 0 U2 2 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0039-7911 J9 SYNTHETIC COMMUN JI Synth. Commun. PY 2012 VL 42 IS 18 BP 2664 EP 2675 DI 10.1080/00397911.2011.564342 PG 12 WC Chemistry, Organic SC Chemistry GA 949RL UT WOS:000304593400003 ER PT S AU Brar, NS Joshi, VS AF Brar, N. S. Joshi, V. S. BE Elert, ML Buttler, WT Borg, JP Jordan, JL Vogler, TJ TI ANISOTROPIC EFFECTS ON CONSTITURIVE MODEL PARAMETERS OF ALUMINUM ALLOYS SO SHOCK COMPRESSION OF CONDENSED MATTER - 2011, PTS 1 AND 2 SE AIP Conference Proceedings LA English DT Proceedings Paper CT 7th Biennial Conference of the American-Physical-Society-Topical-Group on Shock Compression of Condensed Matter CY JUN 26-JUL 01, 2011 CL Chicago, IL SP Amer Phys Soc (APS), Top Grp, Los Alamos Natl Lab, Lawrence Livermore Natl Lab, Sandia Natl Labs DE Aluminum; projectile impact simulation; strain rate sensitivity; Johnson-Cook; constitutive model ID STRAIN RATES; TEMPERATURES AB Simulation of low velocity impact on structures or high velocity penetration in armor materials heavily rely on constitutive material models. Model constants are determined from tension, compression or torsion stress-strain at low and high strain rates at different temperatures. These model constants are required input to computer codes (LS-DYNA, DYNA3D or SPH) to accurately simulate fragment impact on structural components made of high strength 7075-T651aluminum alloy. Johnson-Cook model constants determined for Al7075-T651 alloy bar material failed to simulate correctly the penetration into 1" thick Al-7075-T651plates. When simulation go well beyond minor parameter tweaking and experimental results show drastically different behavior it becomes important to determine constitutive parameters from the actual material used in impact/penetration experiments. To investigate anisotropic effects on the yield/flow stress of this alloy quasi-static and high strain rate tensile tests were performed on specimens fabricated in the longitudinal "L", transverse "T", and thickness "TH" directions of 1" thick Al7075 Plate. While flow stress at a strain rate of similar to 1/s as well as similar to 1100/s in the thickness and transverse directions are lower than the longitudinal direction. The flow stress in the bar was comparable to flow stress in the longitudinal direction of the plate. Fracture strain data from notched tensile specimens fabricated in the L, T, and Thickness directions of 1" thick plate are used to derive fracture constants. C1 [Brar, N. S.] Univ Dayton, Res Inst, Dayton, OH 45469 USA. [Joshi, V. S.] Naval Surface Warfare Ctr, Indian Head, MD 20640 USA. RP Brar, NS (reprint author), Univ Dayton, Res Inst, Dayton, OH 45469 USA. NR 5 TC 0 Z9 0 U1 2 U2 7 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-1006-0 J9 AIP CONF PROC PY 2012 VL 1426 DI 10.1063/1.3686224 PG 4 WC Physics, Applied; Physics, Condensed Matter SC Physics GA BZS44 UT WOS:000302774300012 ER PT S AU Koch, JD Carney, JR Lightstone, JM Piecuch, SR AF Koch, Jon D. Carney, Joel R. Lightstone, James M. Piecuch, Scott R. BE Elert, ML Buttler, WT Borg, JP Jordan, JL Vogler, TJ TI USE OF A FAST NEAR-INFRARED SPECTROMETER FOR ABSORPTION AND EMISSION MEASUREMENTS WITHIN THE EXPANDING BLAST WAVE OF A HIGH EXPLOSIVE SO SHOCK COMPRESSION OF CONDENSED MATTER - 2011, PTS 1 AND 2 SE AIP Conference Proceedings LA English DT Proceedings Paper CT 7th Biennial Conference of the American-Physical-Society-Topical-Group on Shock Compression of Condensed Matter CY JUN 26-JUL 01, 2011 CL Chicago, IL SP Amer Phys Soc (APS), Top Grp, Los Alamos Natl Lab, Lawrence Livermore Natl Lab, Sandia Natl Labs DE Combustion; Detonations; Infrared Spectroscopy AB We demonstrate the use of a fast InGaAs array and spectrometer to measure properties related to near-infrared absorption and emission (750 nm -1500 nm) following a high explosive detonation. Using a broadband light source and a rigid absorption gauge, gas temperatures are measured at a rate of 20 kHz for a period of several milliseconds behind the blast wave from a PETN, PBXN-5, and PBXN-113 detonations. The temperature and concentration of water vapor is determined by fitting experimental transmission spectra to a simulated database. Strong emission signatures obtained during the PETN breakout event (integrated over approximately the first 20 microseconds) indicate the presence of high energy nitrogen and oxygen atoms. Measurements from water absorption at a distance of 23 cm from the PETN charge indicate temperatures decaying from 1600 K to 600 K during the first few milliseconds, and measurements of non-ideal explosives with optically thick post-detonation environments are also demonstrated. These measurements are intended to aid the development of detonation and explosive simulations. C1 [Koch, Jon D.] Marquette Univ, Dept Mech Engn, Milwaukee, WI 53233 USA. [Carney, Joel R.; Lightstone, James M.; Piecuch, Scott R.] Naval Surface Warfare Ctr, Indian Head Div, Res & Technol Div, Indian Head, MD 20640 USA. RP Koch, JD (reprint author), Marquette Univ, Dept Mech Engn, Milwaukee, WI 53233 USA. FU Defense Threat Reduction Agency FX Funding for this work was provided by the Defense Threat Reduction Agency. NR 8 TC 0 Z9 0 U1 0 U2 6 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-1006-0 J9 AIP CONF PROC PY 2012 VL 1426 DI 10.1063/1.3686299 PG 4 WC Physics, Applied; Physics, Condensed Matter SC Physics GA BZS44 UT WOS:000302774300087 ER PT S AU Monat, JE Carney, JR Lightstone, JM Shimizu, N AF Monat, Jeremy E. Carney, Joel R. Lightstone, James M. Shimizu, Nobumichi BE Elert, ML Buttler, WT Borg, JP Jordan, JL Vogler, TJ TI DETERMINING THE SOURCE OF OXYGEN IN POST-DETONATION COMBUSTION OF ALUMINUM SO SHOCK COMPRESSION OF CONDENSED MATTER - 2011, PTS 1 AND 2 SE AIP Conference Proceedings LA English DT Proceedings Paper CT 7th Biennial Conference of the American-Physical-Society-Topical-Group on Shock Compression of Condensed Matter CY JUN 26-JUL 01, 2011 CL Chicago, IL SP Amer Phys Soc (APS), Top Grp, Los Alamos Natl Lab, Lawrence Livermore Natl Lab, Sandia Natl Labs DE Aluminum; aluminum oxide; oxidation; PBXN-113; secondary ion mass spectrometry; oxygen isotope ratio AB Aluminum is commonly added to explosive formulations in the form of micron-sized particles to increase the energy released. The aluminum particles typically combust by reacting with oxidizers from the detonation products (such as CO2 and H2O) and the surrounding atmosphere (O-2). Quantifying the oxygen contribution from these sources is important for improved modeling and formulation of advanced energetics. Using isotopic labeling, this work aims to determine the ratio of oxygen from detonation products to oxygen from the atmosphere involved in the oxidation of aluminum. We detonated a 10-20 g aluminum-containing explosive formulation in a simulated air atmosphere where the oxygen was O-18(2). We collected the solid detonation products after detonation and analyzed the Al2O3 using secondary ion mass spectrometry (SIMS) to measure the ratio of O-18 to O-16. By comparing the measured oxygen isotope ratio to its natural abundance, we determined the percentage of oxygen for aluminum combustion from the detonation products versus the atmosphere. Detonations performed in a rigid chamber showed that 62.0+/-0.3% of the oxygen came from the atmosphere. In further experiments, we created a free-field condition by performing detonations in flexible, thin-walled plastic balls of known radius containing an O-18(2)-enriched air atmosphere. About 0.5-5% of the oxygen in the resulting Al2O3 residue came from the atmosphere. C1 [Monat, Jeremy E.; Carney, Joel R.; Lightstone, James M.] Naval Surface Warfare Ctr, Indian Head Div, Res & Technol Dept, Indian Head, MD 20640 USA. [Shimizu, Nobumichi] Woods Hole Oceanog Inst, Woods Hole, MA 02543 USA. RP Monat, JE (reprint author), Naval Surface Warfare Ctr, Indian Head Div, Res & Technol Dept, Indian Head, MD 20640 USA. NR 4 TC 0 Z9 0 U1 0 U2 1 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-1006-0 J9 AIP CONF PROC PY 2012 VL 1426 DI 10.1063/1.3686305 PG 4 WC Physics, Applied; Physics, Condensed Matter SC Physics GA BZS44 UT WOS:000302774300093 ER PT J AU Gramann, K Wing, S Jung, TP Viirre, E Riecke, BE AF Gramann, Klaus Wing, Shawn Jung, Tzyy-Ping Viirre, Erik Riecke, Bernhard E. TI Switching Spatial Reference Frames for Yaw and Pitch Navigation SO SPATIAL COGNITION AND COMPUTATION LA English DT Article DE spatial navigation; egocentric; allocentric; reference frames; individual differences; yaw pitch navigation; navigation strategies ID ALLOCENTRIC REFERENCE FRAMES; VIRTUAL-REALITY; COGNITIVE STRATEGIES; PATH-INTEGRATION; SPACE; TASK; ORIENTATION; LOCOMOTION; POSITION; ROTATION AB Humans demonstrate preferences to use egocentric or allocentric reference frames in navigation tasks that lack embodied (vestibular and/or proprioceptive) cues. Here, we investigated how reference frame proclivities affect spatial navigation in horizontal versus vertical planes. Point-to-origin performance after visually displayed vertical trajectories was surprisingly accurate and almost matched yaw performance for both egocentric and allocentric strategies. For vertical direction changes, 39% of participants unexpectedly switched to their non-preferred (allocentric) reference frame. This might be explained by vertical (25 degrees-90 degrees up/downward pitched) trajectories having lower ecological validity and creating more pronounced visuo-vestibular conflicts, emphasizing individual differences in processing idiothetic, embodied sensory information. C1 [Gramann, Klaus] Univ Calif San Diego, Inst Neural Computat, Swartz Ctr Computat Neurosci, La Jolla, CA 92093 USA. [Wing, Shawn; Viirre, Erik] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Riecke, Bernhard E.] Simon Fraser Univ, Sch Interact Arts & Technol, Surrey, England. RP Gramann, K (reprint author), Univ Calif San Diego, Inst Neural Computat, Swartz Ctr Computat Neurosci, La Jolla, CA 92093 USA. EM klaus@sccn.ucsd.edu RI Riecke, Bernhard/C-6399-2011 OI Riecke, Bernhard/0000-0001-7974-0850 NR 41 TC 6 Z9 6 U1 2 U2 12 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1387-5868 EI 1542-7633 J9 SPAT COGN COMPUT JI Spat. Cogn. Comput. PY 2012 VL 12 IS 2-3 SI SI BP 159 EP 194 DI 10.1080/13875868.2011.645176 PG 36 WC Psychology, Experimental SC Psychology GA 931XN UT WOS:000303252700006 ER PT J AU MacGregor, AJ Han, PP Dougherty, AL Galarneau, MR AF MacGregor, Andrew J. Han, Peggy P. Dougherty, Amber L. Galarneau, Michael R. TI Effect of Dwell Time on the Mental Health of US Military Personnel With Multiple Combat Tours SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; GULF-WAR; DEPLOYMENT; COHORT; SYMPTOMS; VETERANS; SOLDIERS; IMPACT; IRAQ AB Objective. We investigated the association of the length of time spent at home between deployments, or dwell time, with posttraumatic stress disorder (PTSD) and other mental health disorders. Methods. We included US Marine Corps personnel identified from military deployment records who deployed to Operation Iraqi Freedom once (n = 49 328) or twice (n = 16376). New-onset mental health diagnoses from military medical databases were included. We calculated the ratio of dwell-to-deployment time (DDR) as the length of time between deployments divided by the length of the first deployment. Results. Marines with 2 deployments had higher rates of PTSD than did those with 1 deployment (2.1% versus 1.2%; P<.001). A DDR representing longer dwell times at home relative to first deployment length was associated with reduced odds of PTSD (odds ratio [OR] = 0.47; 95% confidence interval [CI] = 0.32, 0.70), PTSD with other mental health disorder (OR = 0.56; 95% CI = 0.33, 0.94), and other mental health disorders (OR = 0.62; 95% CI = 0.51, 0.75). Conclusions. Longer dwell times may reduce postdeployment risk of PTSD and other mental health disorders. Future research should focus on the role of dwell time in adverse health outcomes. (Am J Public Health. 2012;102:S55-S59. doi:10.2105/AJPH.2011.300341) C1 [MacGregor, Andrew J.; Han, Peggy P.; Dougherty, Amber L.; Galarneau, Michael R.] USN, Dept Med Modeling Simulat & Mission Support, Hlth Res Ctr, San Diego, CA 92106 USA. RP MacGregor, AJ (reprint author), USN, Dept Med Modeling Simulat & Mission Support, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. EM andrew.macgregor@med.navy.mil FU US Navy Bureau of Medicine and Surgery FX This work was supported by the US Navy Bureau of Medicine and Surgery under the Wounded, Ill, and Injured/Psychological Health/Traumatic Brain Injury program. NR 21 TC 16 Z9 16 U1 0 U2 3 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PY 2012 VL 102 SU 1 BP S55 EP S59 DI 10.2105/AJPH.2011.300341 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 893EO UT WOS:000300338600019 PM 22390601 ER PT J AU Abras, JN Lynch, CE Smith, MJ AF Abras, Jennifer N. Lynch, C. Eric Smith, Marilyn J. TI Computational Fluid Dynamics-Computational Structural Dynamics Rotor Coupling Using an Unstructured Reynolds-Averaged Navier-Stokes Methodology SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article ID PREDICTION; FUSELAGE; FLOWS; MESHES; LOADS; CFD AB The focus of this paper is to discuss the unique challenges introduced through the use of unstructured grids in rotorcraft computational fluid dynamics (CFD)-computational structural dynamics (CSD) coupling. The use of unstructured grid methodology in CFD has been expanding because of the advantages in grid generation and modeling of complex configurations. However, the resulting amorphous distribution of the grid points on the rotor blade surface provides no information with regard to the orientation of the blade, in direct contrast to structured grid methodology that can take advantage of the ordered mapping of points to identify the orientation as well as simplifying airloads integration. A methodology has been developed and is described here, which now permits unstructured methods to be utilized for elastic rotary-wing simulations. This methodology is evaluated through comparison of the UH60A rotor with available flight test data for forward flight. C1 [Abras, Jennifer N.] NAVAIR, Patuxent River, MD 20670 USA. [Lynch, C. Eric; Smith, Marilyn J.] Georgia Inst Technol Atlanta, Atlanta, GA USA. RP Abras, JN (reprint author), NAVAIR, Patuxent River, MD 20670 USA. EM jennifer.abras@navy.mil RI Smith, Marilyn/E-4961-2012 FU Vertical Lift Center of Excellence at the Georgia Institute of Technology; U.S. Army; HPC FX This work was sponsored in part by the Vertical Lift Center of Excellence at the Georgia Institute of Technology, and Dr. Michael Rutkowski has been the technical monitor of this center. Computational support was provided through the DoD High Performance Computing Centers at MHPCC, ERDC, and NAVO through an HPC grant from the U.S. Army. Dr. Roger Strawn is the S/AAA of this HPC grant. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the Department of the Army or the U.S. Government. The authors thank the FUN3D Developer's Group at NASA Langley Research Center, in particular Dr. Bob Biedron and Ms. Elizabeth Lee-Rausch, as well as Dr. Ralph Noack at Penn State University, Dr. David O'Brien, Prof. Olivier Bauchau, Dr. Bob Ormiston, and Mr. Alan Egolf. NR 38 TC 2 Z9 2 U1 1 U2 3 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD JAN PY 2012 VL 57 IS 1 AR 012001 DI 10.4050/JAHS.57.012001 PG 14 WC Engineering, Aerospace SC Engineering GA 893AG UT WOS:000300326600001 ER PT J AU Houng, HSH Garner, J Zhou, YF Lyons, A Kuschner, R Deye, G St Clair, K Douce, RW Chicaiza, W Blair, PJ Myers, CA Burke, RL Sanchez, JL Williams, M Halsey, ES AF Houng, Huo-Shu H. Garner, Jason Zhou, Yanfei Lyons, Arthur Kuschner, Robert Deye, Gregory St Clair, Kristina Douce, Richard W. Chicaiza, Wilson Blair, Patrick J. Myers, Christopher A. Burke, Ronald L. Sanchez, Jose L. Williams, Maya Halsey, Eric S. TI Emergent 2009 influenza A(H1N1) viruses containing HA D222N mutation associated with severe clinical outcomes in the Americas SO JOURNAL OF CLINICAL VIROLOGY LA English DT Article DE 2009 A(HINI); Influenza; Severe infections; D222N; HA receptor binding site ID RECEPTOR-BINDING; H5N1 VIRUSES; H1N1; HEMAGGLUTININ; VIRULENCE; SUBSTITUTION; INFECTION AB Background: During the 2010-2011 influenza season, a small sub-group of 2009 influenza A(H1N1) viruses (hereafter referred to as 2009 A(H1N1)) emerged that was associated with more severe clinical outcomes in Ecuador and North America. Genetically, the haemagglutinin (HA) of this sub-clade was distinct from HAs found in viruses associated with severe outbreaks in 2010 from the United Kingdom and from other global specimens isolated earlier in the season. Objective: We report the emergence of a novel 2009 A(H1N1) variant possessing a re-emergent HA D222N mutation obtained from patients with severe respiratory illnesses and phylogenetically characterise these D222N mutants with other severe disease-causing variants clustering within a common emerging sub-clade. Case reports: In early 2011, three cases of 2009 A(H1N1) infection, two from Quito, Ecuador, and one from Washington, DC, USA, were complicated by severe pneumonia requiring mechanical ventilation, resulting in one fatality. These cases were selected due to the reported nature of the acute respiratory distress (ARD) that were captured in Department of Defence (DoD)-sponsored global influenza surveillance nets. Results: Genetically, the 2009 A(H1N1) strains isolated from two of the three severe cases carried a prominent amino acid change at position 222 (D222N) within the primary HA receptor binding site. Furthermore, these cases represent an emerging sub-clade of viruses defined by amino acid changes within HA: N31D, S162N, A186T and V272I. Phylogenetically, these viruses share a high degree of homology with strains associated with recent fatal cases in Chihuahua, Mexico. Discussion: Previously, enhanced virulence associated with the change, D222G, has been clinically linked to severe morbidity and mortality. Initial observations of the prevalence of a novel sub-clade of strains in the Americas suggest that viruses with a re-emergent D222N mutation may too correlate with severe clinical manifestations. These findings warrant heightened vigilance for emerging sub-clades of 2009 A(H1N1) and presumptive clinical implications. (C) 2011 Elsevier B. V. All rights reserved. C1 [Houng, Huo-Shu H.; Zhou, Yanfei; Lyons, Arthur; Kuschner, Robert; Deye, Gregory] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Garner, Jason] USAF, Sch Aerosp Med, Brooks City Base, TX 78235 USA. [Garner, Jason; Sanchez, Jose L.] Henry M Jackson Fdn Adv Mil Med, Rockville, MD 20852 USA. [St Clair, Kristina] Natl Naval Med Ctr, Bethesda, MD 20889 USA. [Douce, Richard W.; Chicaiza, Wilson] Hosp Vozandes Quito, Quito, Ecuador. [Blair, Patrick J.; Myers, Christopher A.] USN, Hlth Res Ctr, San Diego, CA 92106 USA. [Burke, Ronald L.; Sanchez, Jose L.] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD 20904 USA. [Williams, Maya; Halsey, Eric S.] USN, Med Res Unit 6, Lima 205213230, Peru. RP Houng, HSH (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. EM huo-shu.houng@amedd.army.mil RI Lyons, Arthur/B-8923-2011; Valle, Ruben/A-7512-2013; OI Chicaiza-Ayala, Wilson/0000-0001-8639-698X FU United States Department of Defense [847705.82000.25GB.B0016] FX This study was funded by the United States Department of Defense Global Emerging Infections Systems Research Program, Work Unit Number: 847705.82000.25GB.B0016. NR 23 TC 15 Z9 18 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1386-6532 J9 J CLIN VIROL JI J. Clin. Virol. PD JAN PY 2012 VL 53 IS 1 BP 12 EP 15 DI 10.1016/j.jcv.2011.09.004 PG 4 WC Virology SC Virology GA 863DF UT WOS:000298142300003 PM 22036040 ER PT J AU Eng-Kulawy, JK Willis, M AF Eng-Kulawy, J. K. Willis, M. TI IMPROVEMENT IN JOINT MANIFESTATIONS IN A PATIENT WITH MUCOPOLYSACCHARIDOSIS TYPE 1 (MPS I) TREATED WITH ETANERCEPT SO JOURNAL OF INVESTIGATIVE MEDICINE LA English DT Meeting Abstract CT Western Regional Meeting CY JAN 25-28, 2012 CL Carmel, CA C1 [Eng-Kulawy, J. K.; Willis, M.] NMCSD, San Diego, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1081-5589 J9 J INVEST MED JI J. Invest. Med. PD JAN PY 2012 VL 60 IS 1 BP 140 EP 140 PG 1 WC Medicine, General & Internal; Medicine, Research & Experimental SC General & Internal Medicine; Research & Experimental Medicine GA 869XV UT WOS:000298634401051 ER PT J AU Andrews, JA Neises, KD AF Andrews, James A. Neises, Kameran D. TI Cells, biomarkers, and post-traumatic stress disorder: evidence for peripheral involvement in a central disease SO JOURNAL OF NEUROCHEMISTRY LA English DT Review DE biomarkers; PBMC; post-traumatic stress disorder; PTSD ID TRAUMATIC BRAIN-INJURY; ACTIVATED PARENCHYMAL MICROGLIA/MACROPHAGES; TUMOR NECROSIS FACTOR; NEUROPEPTIDE-Y; NEURODEGENERATIVE DISEASES; HIPPOCAMPAL VOLUME; MULTIPLE-SCLEROSIS; IMMUNE-SYSTEM; TNF-ALPHA; INFLAMMATION AB Post-traumatic stress disorder (PTSD) is a complicated CNS syndrome. Looking beyond the CNS, recent studies suggest that peripheral blood mononuclear cells could cause and/or exacerbate PTSD. This review summarizes the literature, describes associations between circulating peripheral blood cells and PTSD, proposes a novel mechanism, and analyzes several biomarkers that appear to associate with PTSD symptoms. Several experimental animal models have shown that peripheral blood mononuclear cell activity can cause hippocampal volume loss and PTSD-like symptoms. Data from these models suggest that a traumatic event and/or traumatic events can trigger peripheral cells to migrate, mediate inflammation, and decrease neurogenesis, potentially leading to CNS volume loss. Biomarkers that associate with PTSD symptoms have the potential to differentiate PTSD from traumatic brain injury, but more work needs to be done. Research examining the mechanism of how traumatic events are linked to peripheral blood mononuclear cell functions and biomarkers may offer improved diagnoses and treatments for PTSD patients. C1 [Andrews, James A.] USN, Hlth Res Ctr, Dept 166, San Diego, CA 92106 USA. RP Andrews, JA (reprint author), USN, Hlth Res Ctr, Dept 166, 140 Sylvester Rd, San Diego, CA 92106 USA. EM james.andrews@med.navy.mil FU Navy Bureau of Medicine and Surgery [60818] FX Report No. 10-27 supported by the Navy Bureau of Medicine and Surgery Psychological Health and Traumatic Brain Injury Program, under Work Unit No. 60818. The views expressed in this article are those of the author and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, or the U. S. Government. Approved for public release; distribution is unlimited. This research has been conducted in compliance with all applicable federal regulations governing the protection of human subjects. No human subjects were directly involved in this research. Special thanks to David Metzgar, PhD, for his assistance in preparation of this manuscript. NR 81 TC 28 Z9 28 U1 3 U2 11 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0022-3042 J9 J NEUROCHEM JI J. Neurochem. PD JAN PY 2012 VL 120 IS 1 BP 26 EP 36 DI 10.1111/j.1471-4159.2011.07545.x PG 11 WC Biochemistry & Molecular Biology; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA 861ZV UT WOS:000298060500004 PM 22017326 ER PT J AU Dehghan, S Liu, EB Seto, J Torres, SF Hudson, NR Kajon, AE Metzgar, D Dyer, DW Chodosh, J Jones, MS Seto, D AF Dehghan, Shoaleh Liu, Elizabeth B. Seto, Jason Torres, Sarah F. Hudson, Nolan R. Kajon, Adriana E. Metzgar, David Dyer, David W. Chodosh, James Jones, Morris S. Seto, Donald TI Five Genome Sequences of Subspecies B1 Human Adenoviruses Associated with Acute Respiratory Disease SO JOURNAL OF VIROLOGY LA English DT Article ID COMPUTATIONAL ANALYSIS; RECOMBINATION; INFECTION; GENE AB Five genomes of human subspecies B1 adenoviruses isolated from cases of acute respiratory disease have been sequenced and archived for reference. These include representatives of two prevalent genomic variants of HAdV-7, i.e., HAdV-7h and HAdV7d2. The other three are HAdV-3/16, HAdV-16 strain E26, and HAdV-3+7 strain Takeuchi. All are recombinant genomes. Genomics and bioinformatics provide detailed views into the genetic makeup of these pathogens and insight into their molecular evolution. Retrospective characterization of particularly problematic older pathogens such as HAdV-7h (1987) and intriguing isolates such as HAdV-3+7 strain Takeuchi (1958) may provide clues to their phenotypes and serology and may suggest protocols for prevention and treatment. C1 [Dehghan, Shoaleh; Liu, Elizabeth B.; Seto, Jason; Seto, Donald] George Mason Univ, Sch Syst Biol, Manassas, VA 20110 USA. [Torres, Sarah F.; Hudson, Nolan R.] David Grant USAF Med Ctr, Clin Invest Facil, Travis AFB, CA 94535 USA. [Kajon, Adriana E.] Lovelace Resp Res Inst, Albuquerque, NM 87108 USA. [Metzgar, David] USN, Dept Resp Dis Res, Hlth Res Ctr, San Diego, CA 92106 USA. [Dyer, David W.] Univ Oklahoma, Hlth Sci Ctr, Dept Microbiol & Immunol, Oklahoma City, OK 73104 USA. [Chodosh, James] Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Dept Ophthalmol,Howe Lab, Boston, MA 02114 USA. [Jones, Morris S.] Calif Dept Publ Hlth, Viral & Rickettsial Dis Lab, Richmond, CA 94804 USA. RP Seto, D (reprint author), George Mason Univ, Sch Syst Biol, Manassas, VA 20110 USA. EM dseto@gmu.edu RI Valle, Ruben/A-7512-2013 FU U.S. Public Health Service NIH [EY013124, P30EY014104]; Research to Prevent Blindness, Inc. FX This work was supported in part by U.S. Public Health Service NIH grants EY013124 (D. S., M.S.J., D. W. D., and J.C.) and P30EY014104 (J.C.). J.C. is also funded by an unrestricted grant to the Department of Ophthalmology, Harvard Medical School, from Research to Prevent Blindness, Inc. NR 13 TC 8 Z9 10 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD JAN PY 2012 VL 86 IS 1 BP 635 EP 636 DI 10.1128/JVI.06593-11 PG 2 WC Virology SC Virology GA 865YV UT WOS:000298347700066 PM 22158846 ER PT J AU Kelly, KR Blaszczak, A Haus, JM Patrick-Melin, A Fealy, CE Solomon, TPJ Kalinski, MI Kirwan, JP AF Kelly, Karen R. Blaszczak, Alecia Haus, Jacob M. Patrick-Melin, Aimee Fealy, Ciaran E. Solomon, Thomas P. J. Kalinski, Michael I. Kirwan, John P. TI A 7-d Exercise Program Increases High-Molecular Weight Adiponectin in Obese Adults SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE LEPTIN; INSULIN SENSITIVITY; LIPID OXIDATION; OBESITY; ADIPOKINES ID TYPE-2 DIABETIC-PATIENTS; HUMAN SKELETAL-MUSCLE; INSULIN SENSITIVITY; PPAR-GAMMA; PLASMA ADIPONECTIN; GLUCOSE-TOLERANCE; ADIPOSE-TISSUE; POSTMENOPAUSAL WOMEN; METABOLIC VARIABLES; EXPRESSION AB KELLY, K. R., A. BLASZCZAK, J. M. HAUS, A. PATRICK-MELIN, C. E. FEALY, T. P. SOLOMON, M. I. KALINSKI, and J. P. KIRWAN. A 7-d Exercise Program Increases High-Molecular Weight Adiponectin in Obese Adults. Med. Sci. Sports Exerc., Vol. 44, No. 1, pp. 69-74, 2012. Purpose: High-molecular weight(HMW) adiponectin is the biologically active form of adiponectin and is related to enhanced insulin sensitivity and metabolic function. Previously, we found that 7 d of exercise improves insulin sensitivity in obese subjects; however, whether short-term exercise training affects HMW adiponectin in obese persons is unknown. Methods: We examined the effect of seven consecutive days of supervised vigorous exercise (60 min center dot d(-1), 85% HRmax) on HMW adiponectin and leptin secretion in 17 obese individuals (age = 55 +/- 3 yr; body mass index = 33.7 +/- 0.9 kg center dot m(-2)). Insulin sensitivity was calculated from an oral glucose tolerance test (ISIOGTT) using the Matsuda Index. Fasting plasma HMW adiponectin and leptin were quantified from blood samples obtained before the ISIOGTT. Glucose and insulin measures were obtained before and every 30 min during the test. Dual-energy x-ray absorptiometry was used to determine body composition, and indirect calorimetry was used to assess fat oxidation. Results: After the intervention, there was a significant increase in HMW adiponectin (3202 +/- 543 vs 3878 +/- 682 ng center dot mL(-1), P = 0.02) and a decrease in leptin (36.8 +/- 5.1 vs 31.1 +/- 4.2 mu g center dot mL(-1), P = 0.03). Further, we observed an increase in ISIOGTT (1.7 +/- 0.3 vs 2.1 +/- 0.3, P = 0.04) and a decrease in glucose area under the curve (30,871 +/- 2105 vs 28,469 +/- 1657 mg center dot dL(-1) for 3 h, P = 0.01). The increase in HMW adiponectin was positively associated with the increase in basal fat oxidation (r = 0.57, P = 0.03), consistent with an improvement in adipose tissue metabolic function. Conclusions: The data suggest that 7 d of exercise is sufficient not only to improve insulin sensitivity and fat oxidation but also to favorably alter adipokine secretion, independent of changes in body weight or composition. C1 [Kelly, Karen R.; Haus, Jacob M.; Patrick-Melin, Aimee; Fealy, Ciaran E.; Solomon, Thomas P. J.; Kirwan, John P.] Cleveland Clin, Lerner Res Inst, Dept Pathobiol, Cleveland, OH 44195 USA. [Kelly, Karen R.; Blaszczak, Alecia; Kirwan, John P.] Case Western Reserve Univ, Sch Med, Dept Nutr, Cleveland, OH USA. [Kelly, Karen R.] USN, Hlth Res Ctr, Dept Warfighter Performance, San Diego, CA 92152 USA. [Haus, Jacob M.; Kirwan, John P.] Case Western Reserve Univ, Sch Med, Dept Physiol & Biophys, Cleveland, OH 44106 USA. [Patrick-Melin, Aimee; Kalinski, Michael I.] Kent State Univ, Coll Educ Hlth & Human Serv, Kent, OH 44242 USA. [Kirwan, John P.] Cleveland Clin, Dept Gastroenterol Hepatol, Cleveland, OH 44106 USA. RP Kirwan, JP (reprint author), Cleveland Clin, Lerner Res Inst, Dept Pathobiol, 9500 Euclid Ave,NE-40, Cleveland, OH 44195 USA. EM kirwanj@ccf.org OI Haus, Jacob/0000-0002-8048-2470 FU National Institutes of Health [RO1 AG12834, T32 DK007319, T32 HL007887-05]; National Institutes of Health National Center for Research Resources, Cleveland [1UL1RR024989] FX This research was supported by a National Institutes of Health grant RO1 AG12834 (J.P.K.) and was supported in part by the National Institutes of Health National Center for Research Resources, 1UL1RR024989, Cleveland, OH. K.R.K. and J.M.H. were supported by National Institutes of Health grants T32 DK007319 and T32 HL007887-05, respectively. NR 40 TC 17 Z9 17 U1 1 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD JAN PY 2012 VL 44 IS 1 BP 69 EP 74 DI 10.1249/MSS.0b013e318228bf85 PG 6 WC Sport Sciences SC Sport Sciences GA 866JT UT WOS:000298377400009 PM 21685815 ER PT J AU Sams, R LaBrie, DW Norris, J Schauer, J Frantz, E AF Sams, Richard LaBrie, D. Walter Norris, Jacob Schauer, Judy Frantz, Earl TI IED Blast Postconcussive Syncope and Autonomic Dysregulation SO MILITARY MEDICINE LA English DT Article ID TRAUMATIC BRAIN-INJURY; CONCUSSION; SEVERITY; IRAQ AB Concussions are the most frequent battle injury sustained in Afghanistan. The Concussion Restoration Care Center provides multidisciplinary care to concussed service members in theater. The Concussion Restoration Care Center has managed over 500 concussions, the majority being from improvised explosive device (LED) blasts. Syncope following a concussion without a loss of consciousness is rarely reported in the literature. The pathophysiology of concussion from a blast injury may be distinct from a concussion secondary to blunt trauma. Two cases of syncope following concussions with an alteration of consciousness are presented, and a mechanism of action is proposed. Post-IED blast concussive symptom frequency at initial presentation on a cohort of patients is reported, with 1.3% of patients experiencing postconcussive syncope. Syncope following an IED blast may be related to centrally mediated autonomic dysregulation at the brain stem level. Syncope should be added to the list of possible symptoms that occur following concussions, in particular concussions following a blast injury. C1 [Sams, Richard] USN, Hosp Jacksonville, Dept Family Med, Jacksonville, FL 32214 USA. [LaBrie, D. Walter] USN, Med Ctr Portsmouth, Portsmouth, VA 23708 USA. [Norris, Jacob] USN, Hlth Res Ctr, Warfighter Performance Dept, San Diego, CA 92106 USA. [Schauer, Judy] USN, Med Clin, Basic Sch, Quantico, VA 22134 USA. [Frantz, Earl] USN, Hosp Camp Lejeune, Sports Med Dept, Camp Lejeune, NC 28547 USA. RP Sams, R (reprint author), USN, Hosp Jacksonville, Dept Family Med, 2080 Child St, Jacksonville, FL 32214 USA. NR 16 TC 5 Z9 5 U1 3 U2 8 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JAN PY 2012 VL 177 IS 1 BP 48 EP 51 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 874RP UT WOS:000298976100012 PM 22338979 ER PT B AU Salamanca-Riba, L Isaacs, R Mansour, AN Hall, A Forrest, DR LeMieux, MC Shugart, J AF Salamanca-Riba, Lourdes Isaacs, Romaine Mansour, Azzam N. Hall, Adam Forrest, David R. LeMieux, Melburne C. Shugart, Jason BE Laudon, M Romanowicz, B TI A New Type of Carbon Nanostructure Formed Within a Metal-Matrix SO NANOTECHNOLOGY 2012, VOL 1: ADVANCED MATERIALS, CNTS, PARTICLES, FILMS AND COMPOSITES LA English DT Proceedings Paper CT NSTI Nanotechnology Conference and Expo (Nanotech 2012) CY JUN 18-21, 2012 CL Santa Clara, CA SP ACCT Canada, Anaheim Ctr New Energy Technol, Angel Capital Assoc, Antenna Syst Magazine, Appl Mat, Arsenal Venture Partners, Austin Energy, AUTM, BASF, Battery Power Magazine, Carbon Credit Capital, CHInano2011, Clean Technol & Sustainable Ind, Org CTSI, Circuits Multi Projets, Constellat Energy, Eco Business com, EcoSeed, European Patent Off, Fraunhofer TechBridge, GigaOM, Green Blog Network, Greenberg Traurig, Hitachi High Technol Am Inc, Inst Civil Engineers, Insight InterAsia, IOP Publish, Jackson Walker LLP, Japan Technol Grp, Kauffman Fdn, Lam Res Corp, Licens Execut Soc, Lux Res, Mead Westvaco, MEMS Ind Grp, Nano Sci & Technol Inst, nano tech Japan, Natl Grid, Natl Venture Capital Assoc, Nanotechnol Ind Assoc, NE Utilities, PPG Ind, SciTech Patent Art, Shell GameChanger, SK Innovat, So California Edison, Taylor & Francis Grp LLC - CRC Press, TechConnect, Texas Nanotechnol Initiat, Env Business Cluster, Natl Assoc Seed & Venture, Funds NASVF, Zyvex Technol DE covetics; metal-carbon compounds; nanocarbon; Raman; EELS ID AMORPHOUS-CARBON; NANOTUBES AB Recent advances in nanomanufacturing have made it possible for large amounts (> 6 wt.%) of carbon to be incorporated as nanoscale carbon during a reaction process in molten aluminum, copper, silver, and other metals. These materials developed by Third Millennium Metals, LLC are called "covetics". The carbon is highly stable despite its form not being predicted in phase diagrams, and remains dispersed after remelting and resolidification. The carbon incorporates into the metal matrix and has an effect on several of the properties of the material. We have performed a detailed investigation of the structure and composition of several covetics using a variety of microscopy and spectroscopy techniques and found that the carbon forms nanoparticles of 5-200 nm diameter that are embedded in the host matrix. EELS spectra obtained from these regions show characteristic shape of carbon nanotubes (CNT). Raman data obtained from these samples also show the G-mode and D-mode characteristic of CNT. C1 [Salamanca-Riba, Lourdes; Isaacs, Romaine] Univ Maryland, College Pk, MD 20742 USA. [Mansour, Azzam N.; Forrest, David R.] Naval Surface Warfare Ctr, Carderock Div, West Bethesda, MD USA. [Hall, Adam] Univ North Carolina Greensboro, Greensboro, NC USA. [LeMieux, Melburne C.] C3Nano, Hayward, CA USA. [Shugart, Jason] Third Millenium Met LLC, Waverly, OH USA. RP Salamanca-Riba, L (reprint author), Univ Maryland, College Pk, MD 20742 USA. EM riba@umd.edu; azzam.mansour@navy.mil; arhall5@uncg.edu; david.forrest@navy.mil; melbs@3cnano.com; ishugart@Jrnmetals.com NR 5 TC 0 Z9 0 U1 2 U2 2 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-6274-5 PY 2012 BP 278 EP 281 PG 4 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA BG7DX UT WOS:000391247800074 ER PT B AU Forrest, DR Jasiuk, I Brown, CL Joyce, P Mansour, A Salamanca-Riba, L AF Forrest, David R. Jasiuk, Iwona Brown, Capt Lloyd Joyce, Peter Mansour, Azzam Salamanca-Riba, Lourdes BE Laudon, M Romanowicz, B TI Novel Metal-Matrix Composites with Integrally-Bound Nanoscale Carbon SO NANOTECHNOLOGY 2012, VOL 1: ADVANCED MATERIALS, CNTS, PARTICLES, FILMS AND COMPOSITES LA English DT Proceedings Paper CT NSTI Nanotechnology Conference and Expo (Nanotech 2012) CY JUN 18-21, 2012 CL Santa Clara, CA SP ACCT Canada, Anaheim Ctr New Energy Technol, Angel Capital Assoc, Antenna Syst Magazine, Appl Mat, Arsenal Venture Partners, Austin Energy, AUTM, BASF, Battery Power Magazine, Carbon Credit Capital, CHInano2011, Clean Technol & Sustainable Ind, Org CTSI, Circuits Multi Projets, Constellat Energy, Eco Business com, EcoSeed, European Patent Off, Fraunhofer TechBridge, GigaOM, Green Blog Network, Greenberg Traurig, Hitachi High Technol Am Inc, Inst Civil Engineers, Insight InterAsia, IOP Publish, Jackson Walker LLP, Japan Technol Grp, Kauffman Fdn, Lam Res Corp, Licens Execut Soc, Lux Res, Mead Westvaco, MEMS Ind Grp, Nano Sci & Technol Inst, nano tech Japan, Natl Grid, Natl Venture Capital Assoc, Nanotechnol Ind Assoc, NE Utilities, PPG Ind, SciTech Patent Art, Shell GameChanger, SK Innovat, So California Edison, Taylor & Francis Grp LLC - CRC Press, TechConnect, Texas Nanotechnol Initiat, Env Business Cluster, Natl Assoc Seed & Venture, Funds NASVF, Zyvex Technol DE nanocarbon; covetic; nanomaterial; metal-matrix composite AB We characterized the chemical, thermophysical, and mechanical properties of nanomaterials with up to 5 wt% nanocarbon (aka "covetics") in aluminum and copper metals. The nanocarbon is detectable by EDS and XPS but not by analytical methods such as LECO and GDMS. Nanocarbon raises the melting point and significantly alters surface tension, and thus porosity, during solidification. Open questions remain about the observation of higher density than would be predicted by the rule of mixtures. In aluminum alloys, we observed an increase in as-rolled strength and hardness with increasing amounts of nanocarbon. In copper, thermal conductivity was anisotropic: up to 50% higher in the extrusion direction and at least 25% lower in the transverse direction, and was different between transient and steady state test conditions. In aluminum, we observed a significant increase in electrical conductivity with nanocarbon, from 47 to 67% IACS. These materials are commercially promising because they are produced by conversion of inexpensive carbon powder to nanocarbon in the melt paving the way for the production of nanomaterials in pyrometallurgical operations with economies of scale. C1 [Forrest, David R.; Mansour, Azzam] Naval Surface Warfare Ctr, Bethesda, MD 20817 USA. [Jasiuk, Iwona] Univ Illinois, Urbana, IL USA. [Brown, Capt Lloyd; Joyce, Peter] US Naval Acad, Annapolis, MD 21402 USA. [Salamanca-Riba, Lourdes] Univ Maryland, College Pk, MD 20742 USA. RP Forrest, DR (reprint author), Naval Surface Warfare Ctr, Bethesda, MD 20817 USA. EM david.r.forrest@navy.mil; ijasiuk@illinois.edu; lbrown@usna.edu; pjoyce@usna.edu; azzam.mansour@navy.mil; riba@umd.edu OI Joyce, Peter/0000-0001-6774-2170; Jasiuk, Iwona/0000-0001-9663-4734 NR 3 TC 0 Z9 0 U1 1 U2 1 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-6274-5 PY 2012 BP 560 EP 563 PG 4 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA BG7DX UT WOS:000391247800148 ER PT B AU Ghosh, S Risley, T Sobolewski, D Welch, W Williams, S AF Ghosh, Sujit Risley, Tom Sobolewski, David Welch, William Williams, Sherry GP ASME TI MARINE ALTERNATIVE FUEL PERFORMANCE TESTING SO PROCEEDINGS OF THE ASME INTERNAL COMBUSTION ENGINE DIVISION SPRING TECHNICAL CONFERENCE 2012 LA English DT Proceedings Paper CT ASME Internal Combustion Engine Division Spring Technical Conference CY MAY 06-09, 2012 CL Politecn Torino, Torino, ITALY SP ASME, Internal Combus Engine Div HO Politecn Torino AB As part of the U.S. Maritime Administration (MARAD) marine application of alternative fuel initiative, the U.S. Navy provided neat hydrotreated renewable diesel (HRD), derived from the hydroprocessing of algal oils, for operational and exhaust emission testing onboard the T/S STATE OF MICHIGAN. This vessel has diesel-electric propulsion with four caterpillar D-398 compression ignition engines; one of these ship service diesel engines was selected as the test engine. The diesel generator sets power both the propulsion motors propelling the ship and provide the electrical power for the hotel loads of the ship. Ultra-low sulfur diesel (ULSD) was blended with the neat HRD fuel in a 50/50-by-volume blend and tested for over 440 hours on the vessel. Exhaust emissions testing was performed while underway on Lake Michigan using the baseline ULSD assessed earlier. A similar profile was run using the blended test fuel. Emission testing was conducted using the ISO 8178 (D2) test cycle. When emissions testing was completed a series of underway and pierside test runs were conducted to accumulate the remaining engine hours, After all testing, the engine conditions were assessed again using a combination of visual inspection and oil analysis. The remainder of the test fuel will be used to conduct a long-term stability test. The setup, test, and results of this testing, currently underway, are reported here with a discussion of MARAD's alternative fuels test initiative. C1 [Ghosh, Sujit] US Maritime Adm, Washington, DC 20590 USA. [Risley, Tom] Life Cycle Engn, Pittsburgh, PA USA. [Sobolewski, David] TS STATE MICHIGAN, Traverse City, MI USA. [Welch, William] Univ Calif Riverside, Riverside, CA USA. [Williams, Sherry] Naval Air Syst Command, Patuxent River, MD USA. RP Ghosh, S (reprint author), US Maritime Adm, Washington, DC 20590 USA. NR 2 TC 1 Z9 3 U1 1 U2 2 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4466-3 PY 2012 BP 203 EP + PG 2 WC Engineering, Mechanical SC Engineering GA BA3XU UT WOS:000335091000021 ER PT B AU Russ, B Dabbeeru, MM Chorney, AS Gupta, SK AF Russ, Brian Dabbeeru, Madan M. Chorney, Andrew S. Gupta, Satyandra K. GP ASME TI AUTOMATED ASSEMBLY MODEL SIMPLIFICATION FOR FINITE ELEMENT ANALYSIS SO PROCEEDINGS OF THE ASME INTERNATIONAL DESIGN ENGINEERING TECHNICAL CONFERENCES AND COMPUTERS AND INFORMATION IN ENGINEERING CONFERENCE 2012, VOL 2, PTS A AND B LA English DT Proceedings Paper CT ASME International Design Engineering Technical Conferences/Computers Information in Engineering Conference CY AUG 12-15, 2012 CL Chicago, IL SP ASME, Design Engn Div, ASME, Comp & Informat Engn Div AB Analyzing complex 3D assembly models using finite element analysis software requires suppressing parts that are not likely to influence the analysis results, but may significantly improve the computational performance during the analysis. The part suppression step often depends on many factors within the context and application of the model. Currently, most analysts perform this step manually. This step can take a long time to perform on a complex model and can be tedious in nature. In this paper, we present an approach to multi-part suppression based on the specified criteria. We have developed utilities in Pro/Engineer CAD system to identify parts that meet the specified criteria and suppress them. We present several examples to illustrate the value of the proposed approach. C1 [Russ, Brian; Dabbeeru, Madan M.; Gupta, Satyandra K.] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. [Chorney, Andrew S.] Naval Air Syst Command, Patuxent River, MD 20670 USA. [Gupta, Satyandra K.] Univ Maryland, Inst Syst Res, College Pk, MD 20742 USA. RP Russ, B (reprint author), Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. EM bruss@umd.edu; mmd@umd.edu; andrew.chorney@navy.mil; skgupta@umd.edu FU Patuxent River Naval Air Warfare Center FX This work is done in collaboration and funded by Patuxent River Naval Air Warfare Center. NR 17 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4501-1 PY 2012 BP 197 EP + PG 2 WC Computer Science, Interdisciplinary Applications; Engineering, Multidisciplinary SC Computer Science; Engineering GA BA4KX UT WOS:000335932700023 ER PT B AU Nichols, JW Lele, SK Ham, FE Martens, S Spyropoulos, JT AF Nichols, Joseph W. Lele, Sanjiva K. Ham, Frank E. Martens, Steve Spyropoulos, John T. GP ASME TI CRACKLE NOISE IN HEATED SUPERSONIC JETS SO PROCEEDINGS OF THE ASME TURBO EXPO 2012, VOL 1 LA English DT Proceedings Paper CT ASME Turbo Expo 2012 CY JUN 11-15, 2012 CL Copenhagen, DENMARK SP Int Gas Turbine Inst ID SIMULATION AB Crackle noise from heated supersonic jets is characterized by the presence of strong positive pressure impulses resulting in a strongly skewed far-field pressure signal. These strong positive pressure impulses are associated with. "N-shaped" waveforms involving a shock-like compression, and thus is very annoying to observers when it occurs. Unlike broadband shock-associated noise which dominates at upstream angles, crackle reaches a maximum at downstream angles associated with the peak jet noise directivity. Recent experiments [1] have shown that the addition of chevrons to the nozzle lip can significantly reduce crackle, especially in full-scale high-power tests. Because of these observations, it was conjectured that crackle is associated with coherent large scale flow structures produced by the baseline nozzle, and that the formation of these structures are interrupted by the presence of the chevrons, which leads to noise reduction. In particular, shocklets attached to large eddies are postulated as a possible aerodynamic mechanism for the formation of crackle. In this paper, we test this hypothesis through high-fidelity Large-Eddy Simulation (LES) of a hot supersonic jet of Mach number 1.56 and total temperature temperature ratio of 3.65. We use the LES solver "CharLES," developed by Cascade Technologies, Inc., to capture the turbulent jet plume on fully-unstructured meshes. C1 [Nichols, Joseph W.; Lele, Sanjiva K.] Stanford Univ, Stanford, CA 94305 USA. [Ham, Frank E.] Cascade Technol Inc, Palo Alto, CA USA. [Martens, Steve] GE Global Res, Niskayuna, NY USA. [Spyropoulos, John T.] Naval Air Syst Command, Patuxent River, MD USA. RP Nichols, JW (reprint author), Stanford Univ, Stanford, CA 94305 USA. NR 13 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4467-0 PY 2012 BP 337 EP + PG 2 WC Engineering, Mechanical SC Engineering GA BA4HH UT WOS:000335720700032 ER PT B AU Morscher, GN Baker, C Ramasamy, S Choi, S Faucett, C AF Morscher, Gregory N. Baker, Christopher Ramasamy, Sivakumar Choi, Sung Faucett, Calvin GP ASME TI USE OF ELECTRICAL RESISTIVITY AND ACOUSTIC EMISSION TO ASSESS IMPACT DAMAGE STATES IN TWO SIC-BASED CMCS SO PROCEEDINGS OF THE ASME TURBO EXPO 2012, VOL 1 LA English DT Proceedings Paper CT ASME Turbo Expo 2012 CY JUN 11-15, 2012 CL Copenhagen, DENMARK SP Int Gas Turbine Inst ID CERAMIC-MATRIX COMPOSITES; STRESS-RUPTURE; ACCUMULATION; AIR AB The need to assess damage is essential to accurately predict the degradation of the composite properties such as remaining strength and specimen/component life expectancy. Two methods were used to assess as to their usefulness for damage quantification (acoustic emission) and damage monitoring (electrical resistivity) on two different CMC composites which have undergone impact damage. In particular melt-infiltrated composites with fiber types, SA and ZMI, are examined which were impacted with high velocity projectiles (similar to Mach 1), and tested in tension after high velocity impact. Electrical resistivity was used as both an inspection technique (measured before and after impact testing) as well as a damage monitoring technique in parallel with acoustic emission during tensile testing. The effect of damage was evident from the change in measured electrical resistivity due to impact and during tensile testing. It was also evident from AE activity during tensile testing that crack propagation occurred at relatively low stresses for composites with significant impact damage. C1 [Morscher, Gregory N.; Baker, Christopher; Ramasamy, Sivakumar] Univ Akron, Akron, OH 44325 USA. [Choi, Sung; Faucett, Calvin] NAVAIR, Patuxen, MD USA. RP Morscher, GN (reprint author), Univ Akron, Akron, OH 44325 USA. FU ONR [N00014-11-10765] FX This work is sponsored by an ONR Grant N00014-11-10765 and monitored by William Nickerson. We also wish to thank Goodrich Inc. for the composites used in this study. NR 17 TC 0 Z9 0 U1 1 U2 7 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4467-0 PY 2012 BP 487 EP + PG 2 WC Engineering, Mechanical SC Engineering GA BA4HH UT WOS:000335720700044 ER PT B AU Choi, SR Faucett, DC AF Choi, Sung R. Faucett, D. Calvin GP ASME TI COMBINED EFFECTS OF CMAS AND FOD IN CERAMIC MATRIX COMPOSITES SO PROCEEDINGS OF THE ASME TURBO EXPO 2012, VOL 1 LA English DT Proceedings Paper CT ASME Turbo Expo 2012 CY JUN 11-15, 2012 CL Copenhagen, DENMARK SP Int Gas Turbine Inst DE CMAS (calcium-magnesium-aluminosilicate); salt (sodium sulfate); ceramic matrix composites (CMCs); MI SiC/SiC; N720/alumina; oxide/oxide; foreign object damage (FOD); ballistic impact testing; strength degradation; mechanical testing ID THERMAL BARRIER COATINGS; ELEVATED-TEMPERATURES; DELAMINATION; INFILTRATION; DEGRADATION; CORROSION; MECHANISM; SUBJECT AB The combined effects of CMAS (calcium magnesium aluminosilicate) and POD (foreign object damage) were determined in three different ceramic matrix composites (CMCs), two melt-infiltrated (MI) SiC/SiCs and one oxide/oxide. Foreign object damage was introduced at ambient temperature in CMC test targets using 1.6 mm steel ball projectiles at an impact velocity of 340 m/s utilizing a ballistic impact gun. One type of target support, partial support, was used. The impact-damaged test coupons were then CMAS-exposed at 1200 degrees C for 10 hrs in air. Additional tests were also performed by exposing impact-damaged test coupons to a mixture of CMAS and salt (sodium sulfate) at 1200 degrees C for 10 hrs in air. The combined effects of POD and CMAS or CMAS/salt were quantified by determining the residual strengths of test coupons after exposures. Also, six different sands ingested into aeroengines were analyzed in their chemical compositions. The melt CMAS solid, melted at 1300 degrees C and solidified, was assessed in its mechanical properties of microhardness and fracture toughness. C1 [Choi, Sung R.; Faucett, D. Calvin] Naval Air Syst Command, Patuxent River, MD 20670 USA. RP Choi, SR (reprint author), Naval Air Syst Command, Patuxent River, MD 20670 USA. EM sung.choi1@navy.mil NR 22 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4467-0 PY 2012 BP 493 EP 500 PG 8 WC Engineering, Mechanical SC Engineering GA BA4HH UT WOS:000335720700045 ER PT B AU Enright, MP Moody, JP Chandra, R Pentz, AC AF Enright, Michael P. Moody, Jonathan P. Chandra, Ramesh Pentz, Alan C. GP ASME TI INFLUENCE OF MISSION VARIABILITY ON FRACTURE RISK OF GAS TURBINE ENGINE COMPONENTS SO PROCEEDINGS OF THE ASME TURBO EXPO 2012, VOL 7, PTS A AND B LA English DT Proceedings Paper CT ASME Turbo Expo 2012 CY JUN 11-15, 2012 CL Copenhagen, DENMARK SP Int Gas Turbine Inst AB The need for application of probabilistic methods to fatigue life prediction of gas turbine engine components is being increasingly recognized by the U.S. Military. A physics-based probabilistic approach to risk assessment provides improved accuracy compared to a statistical assessment of failure data because it can be used to (1) predict future risk and (2) assess the influences of both deterministic and random variables that are not included in the failure data. Probabilistic risk and fatigue life prediction of gas turbine engine fracture critical components requires estimates of the applied stress and temperature values throughout the life of the component. These values are highly dependent upon the, mission type and may vary from flight to flight within the same mission. Currently, standard missions are specified and used during the engine design process, but the associated stresses can differ significantly from stress values that are based on flight data recorder (FDR) information. For this reason, efforts are made to periodically update the standard missions and to assess the impact on component structural integrity and associated risk of fracture. In this paper, the influence of mission type and variability on fracture risk is illustrated for an actual gas turbine engine disk subjected to a number of different mission loadings. Disk stresses associated with each mission were obtained by scaling finite element model results based on RPM values obtained from engine flight recorder data. The variability in stress values throughout the life of the component was modeled using two different approaches to identify the upper and lower bound value influences on the risk of fracture. The remaining variables were based on default values provided in FAA Advisory Circular (AC) 33.14-1 "Damage Tolerance for High Energy Turbine Engine Rotors". The risk of fracture was computed using a probabilistic damage tolerance computer code called DARWIN (R) (Design Assessment of Reliability With Inspection) and compared for each mission type to illustrate the maximum influence of mission type on fracture risk. The results can be used to gain insight regarding the influence of mission type and associated variability on the risk of fracture of realistic engine components. C1 [Enright, Michael P.; Moody, Jonathan P.] SW Res Inst, San Antonio, TX 78238 USA. [Chandra, Ramesh; Pentz, Alan C.] NAVAIR, Patuxent River, MD USA. RP Enright, MP (reprint author), SW Res Inst, San Antonio, TX 78238 USA. FU NAVAIR [N00178-05-D-4395 M801] FX This work was supported by NAVAIR under Contract N00178-05-D-4395 M801. The authors wish to acknowledge the finite element modeling support provided by Mr. Jim Maltby of NAVAIR. NR 17 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4473-1 PY 2012 BP 439 EP + PG 2 WC Engineering, Mechanical SC Engineering GA BA4JO UT WOS:000335868800049 ER PT J AU Crain, JA Larson, GE Highfill-McRoy, RM Schmied, EA AF Crain, Jenny A. Larson, Gerald E. Highfill-McRoy, Robyn M. Schmied, Emily A. TI Postcombat outcomes among marines with preexisting mental diagnoses SO JOURNAL OF TRAUMATIC STRESS LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; HEALTH-PROBLEMS; INTERNALIZING SUBTYPES; RISK-FACTORS; VETERANS; DISASTER; INTELLIGENCE; METAANALYSIS; PREDICTORS; DEPLOYMENT AB Preexisting mental disorders are not always considered in mental health studies with military populations, even though prior diagnoses may be a risk factor for additional psychiatric harm stemming from combat exposure, as well as postdeployment behavioral problems. The objectives of this study were to investigate postcombat psychiatric and career outcomes among Marines with preexisting mental disorder diagnoses who deployed to combat in Iraq, Afghanistan, or Kuwait from 2002 to 2008. Marines with a preexisting diagnosis were 3.6 times (p < .001) more likely to have at least 1 postdeployment mental health disorder within 6 months postdeployment compared with Marines with no prior psychiatric diagnoses. Marines with a preexisting diagnosis were also 1.8 (p < .001) times more likely to receive a new-onset psychiatric diagnosis within 6 months postdeployment, indicating that postdeployment mental health concerns in this cohort extend beyond continuation of earlier disorders. Additionally, demotions and separation were significantly associated with having any preexisting mental health diagnoses (yielding odds ratios of 2.34 and 2.00, p < .001, respectively. Based on the current findings, it may be advisable to mandate a full medical and psychiatric record review during deployment health screening as part of new initiatives to address whether combat exposure has worsened preexisting conditions or compounded them with new-onset concerns. C1 [Crain, Jenny A.; Larson, Gerald E.; Highfill-McRoy, Robyn M.; Schmied, Emily A.] USN, Hlth Res Ctr, Behav Sci & Epidemiol Dept, San Diego, CA 92106 USA. RP Crain, JA (reprint author), USN, Hlth Res Ctr, Behav Sci & Epidemiol Dept, 140 Sylvester Rd, San Diego, CA 92106 USA. EM jenny.crain@med.navy.mil NR 41 TC 4 Z9 4 U1 1 U2 4 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0894-9867 J9 J TRAUMA STRESS JI J. Trauma Stress PD DEC PY 2011 VL 24 IS 6 BP 671 EP 679 DI 10.1002/jts.20700 PG 9 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA 869FF UT WOS:000298581800007 PM 22144144 ER PT J AU Taylor, MK Stanfill, KE Padilla, GA Markham, AE Ward, MD Koehler, MM Anglero, A Adams, BD AF Taylor, Marcus K. Stanfill, Katherine E. Padilla, Genieleah A. Markham, Amanda E. Ward, Michael D. Koehler, Matthew M. Anglero, Antonio Adams, Barry D. TI Effect of Psychological Skills Training During Military Survival School: A Randomized, Controlled Field Study SO MILITARY MEDICINE LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; BURNED SERVICE MEMBERS; SELF-TALK; PERFORMANCE; IRAQ; COMBAT; SYMPTOMS; SOLDIERS; INTERVENTIONS AB In this randomized, controlled field study, we examined the effects of a brief psychological skills training (PST) intervention on stress responses during military survival school. A second purpose was to build upon prior research in this unique environment by extending the follow-up window to 3 months. Baseline subjective distress (dissociative) symptoms were measured in 65 male military subjects, who were then randomized either to PST or a control group that received no training beyond the normal survival school curriculum. PST received training in arousal control, mental imagery, goal setting, and positive self-talk in two separate 40-minute sessions before stressful field exercises. Stress symptoms were then assessed during a mock-captivity phase of training, as well as 24 hours, I month, and 3 months after completion of training. Repeated-measures analyses of variance with follow-up paired (tests examined differences between groups and across time. Survival training precipitated remarkable increases in subjective distress, but few substantive group differences emerged. This study extends prior work quantifying the human stress response to intense military training. C1 [Taylor, Marcus K.; Anglero, Antonio; Adams, Barry D.] USN, Hlth Res Ctr, Dept Behav Sci & Epidemiol 163, San Diego, CA 92106 USA. [Stanfill, Katherine E.; Padilla, Genieleah A.; Markham, Amanda E.] USN, Hlth Res Ctr, Dept Warfighter Performance 162, San Diego, CA 92106 USA. [Ward, Michael D.; Koehler, Matthew M.] Ctr Secur Forces Detachment N Isl, San Diego, CA 92135 USA. RP Taylor, MK (reprint author), USN, Hlth Res Ctr, Dept Behav Sci & Epidemiol 163, San Diego, CA 92106 USA. FU Office of Naval Research [342] FX Appreciation is extended to students and staff at Center for Security Forces-Detachment North Island for "training the best for the worst." We also appreciate Dr. Daniel R. Gould for sharing over 30 years of expertise in psychological skills training of elite performers. Finally, we would like to thank Mr. Matthew Leon for manuscript formatting and proofreading. This study was supported in part by a grant from the Office of Naval Research, Code 342 (Casualty Prevention). This work was performed under work unit number PB401. NR 46 TC 9 Z9 9 U1 2 U2 14 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2011 VL 176 IS 12 BP 1362 EP 1368 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 861OK UT WOS:000298028900003 PM 22338349 ER PT J AU Duplessis, CA Sklar, MJ Maves, RC Spichler, A Hale, B Johnson, M Bavaro, M Vinetz, JM AF Duplessis, Christopher A. Sklar, Marvin J. Maves, Ryan C. Spichler, Anne Hale, Braden Johnson, Mark Bavaro, Mary Vinetz, Joseph M. TI Hemoptysis Associated with Leptospirosis Acquired in Hawaii, USA SO EMERGING INFECTIOUS DISEASES LA English DT Letter C1 [Duplessis, Christopher A.; Sklar, Marvin J.; Maves, Ryan C.; Johnson, Mark; Bavaro, Mary] Naval Med Ctr San Diego, San Diego, CA 92134 USA. [Spichler, Anne; Vinetz, Joseph M.] Univ Calif, La Jolla, CA USA. [Hale, Braden] Naval Hlth Res Ctr, San Diego, CA USA. RP Duplessis, CA (reprint author), Naval Med Ctr San Diego, 34800 Bob Wilson Dr,Suite 5, San Diego, CA 92134 USA. EM chris.duplessis@waldenu.edu OI Vinetz, Joseph/0000-0001-8344-2004 FU FIC NIH HHS [D43TW007120, D43 TW007120]; NIAID NIH HHS [K24 AI068903, K24AI068903] NR 10 TC 3 Z9 3 U1 0 U2 2 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD DEC PY 2011 VL 17 IS 12 BP 2375 EP 2377 DI 10.3201/eid1712.110700 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 859KD UT WOS:000297874400039 PM 22172093 ER PT J AU Eick, AA Faix, DJ Tobler, SK Nevin, RL Lindler, LE Hu, Z Sanchez, JL MacIntosh, VH Russell, KL Gaydos, JC AF Eick, Angelia A. Faix, Dennis J. Tobler, Steven K. Nevin, Remington L. Lindler, Luther E. Hu, Zheng Sanchez, Jose L. MacIntosh, Victor H. Russell, Kevin L. Gaydos, Joel C. TI Serosurvey of Bacterial and Viral Respiratory Pathogens Among Deployed US Service Members SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID HEALTHY-YOUNG ADULTS; UNITED-STATES; MILITARY PERSONNEL; SYNCYTIAL VIRUS; IRAQI-FREEDOM; PERTUSSIS; ILLNESS; ADOLESCENTS; DISEASES; AFGHANISTAN AB Background: Respiratory illnesses can cause substantial morbidity during military deployments. Bordetella pertussis, Chlamydia pneumoniae, Mycoplasma pneumoniae, adenovirus, parainfluenza, and respiratory syncytial virus (RSV) are hypothesized causes. Purpose: To determine pathogen-specific seroprevalence prior to and after deployment in support of Operation Enduring Freedom (OEF). Methods: A retrospective cohort study of 1000 service members deployed between June 30, 2004, and June 30, 2007, was conducted from 2008 through 2009. Pre- and post-deployment sera were tested for the presence of antibody to each pathogen. Results: Pre-deployment IgG seropositivity was high for adenovirus, RSV, and parainfluenza (98.7%, 97.8%, and 81.6%, respectively), whereas seropositivity for B. pertussis, M. pneumoniae, and C. pneumoniae was 14.2%, 21.9%, and 65.1%, respectively. As defined by seroconversion in 1000 subjects, the following were identified: 43 new parainfluenza infections (24% of susceptibles); 37 new pertussis infections (4% of susceptibles); 33 new C. pneumoniae infections (10% of susceptibles); and 29 new M. pneumoniae infections (4% of susceptibles). B. pertussis seroconversion was two to four times higher than reports for the general U. S. population. Overall, 14.2% of the service members seroconverted to at least one of these six pathogens; this increased to 30.1% seroconversion when influenza was included. However, serologic testing was not clearly associated with clinical illness in this report. Conclusions: Serologic evidence for respiratory infections was common among the 2004-2007 OEF-deployed military, sometimes at a higher rate than the general U. S. population. Awareness of this risk and implementation of preventive measures should be emphasized by leadership prior to and during deployment. (Am J Prev Med 2011;41(6):573-580) (C) 2011 American Journal of Preventive Medicine C1 [Eick, Angelia A.; Tobler, Steven K.; Nevin, Remington L.; Lindler, Luther E.; Hu, Zheng; Sanchez, Jose L.; MacIntosh, Victor H.; Russell, Kevin L.; Gaydos, Joel C.] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD 20910 USA. [Faix, Dennis J.] USN, Hlth Res Ctr, Naval Resp Dis Lab, San Diego, CA 92152 USA. [Tobler, Steven K.] Evans Army Community Hosp, Ft Carson, CO USA. [Nevin, Remington L.] Bayne Jones Army Community Hosp, Ft Polk, LA USA. [Lindler, Luther E.] Dept Homeland Secur, Sci & Technol Directorate, Washington, DC USA. [MacIntosh, Victor H.] USAF, Sch Aerosp Med, Wright Patterson AFB, OH 45433 USA. RP Eick, AA (reprint author), Armed Forces Hlth Surveillance Ctr, 11800 Tech Rd, Silver Spring, MD 20910 USA. EM angie.eick@us.army.mil OI Nevin, Remington/0000-0002-0534-1889 FU Naval Health Research Center; DoD Global Emerging Infections Surveillance and Response (DoD-GEIS) [GF0233_06_CH]; Divisions of the Armed Forces Health Surveillance Center, Silver Spring MD FX We would like to acknowledge the excellent laboratory work conducted in support of this study by the Naval Health Research Center. Specifically, we would like to thank Christian Hansen, David Metzgar, and Ryan Ortiguerra for their assistance in running the assays and compiling the results.; Financial support: DoD Global Emerging Infections Surveillance and Response (DoD-GEIS) (Award GF0233_06_CH) (PI:AE) and the Army Medical Surveillance Activity, now Divisions of the Armed Forces Health Surveillance Center, Silver Spring MD. NR 34 TC 12 Z9 12 U1 1 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD DEC PY 2011 VL 41 IS 6 BP 573 EP 580 DI 10.1016/j.amepre.2011.08.006 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 849US UT WOS:000297151400004 PM 22099233 ER PT J AU Thomas, AG Tran, BR Cranston, M Brown, MC Kumar, R Tlelai, M AF Thomas, Anne Goldzier Tran, Bonnie Robin Cranston, Marcus Brown, Malerato Cecilia Kumar, Rajiv Tlelai, Matsotetsi TI Voluntary Medical Male Circumcision: A Cross-Sectional Study Comparing Circumcision Self-Report and Physical Examination Findings in Lesotho SO PLOS ONE LA English DT Article ID PREVALENT HIV-INFECTION; SOUTH-AFRICA; EASTERN CAPE; MEN; PREVENTION; TANZANIA; UGANDA; KENYA; COMPLICATIONS; ADOLESCENTS AB Background: Overwhelming evidence, including three clinical trials, shows that male circumcision (MC) reduces the risk of HIV infection among men. However, data from recent Lesotho Demographic and Health Surveys do not demonstrate MC to be protective against HIV. These contradictory findings could partially be due to inaccurate self-reported MC status used to estimate MC prevalence. This study describes MC characteristics among men applying for Lesotho Defence Force recruitment and seeks to assess MC self-reported accuracy through comparison with physical-examination-based data. Methods and Findings: During Lesotho Defence Force applicant screening in 2009, 241 (77%) of 312 men, aged 18-25 y, consented to a self-administered demographic and MC characteristic survey and physician-performed genital examination. The extent of foreskin removal was graded on a scale of 1 (no evidence of MC) to 4 (complete MC). MC was self-reported by 27% (n = 64/239) of participants. Of the 64 men self-reporting being circumcised, physical exam showed that 23% had no evidence of circumcision, 27% had partial circumcision, and 50% had complete circumcision. Of the MCs reportedly performed by a medical provider, 3% were Grade 1 and 73% were Grade 4. Of the MCs reportedly performed by traditional circumcisers, 41% were Grade 1, while 28% were Grade 4. Among participants self-reporting being circumcised, the odds of MC status misclassification were seven times higher among those reportedly circumcised by initiation school personnel (odds ratio = 7.22; 95% CI = 2.29-22.75). Conclusions: Approximately 27% of participants self-reported being circumcised. However, only 50% of these men had complete MC as determined by a physical exam. Given this low MC self-report accuracy, countries scaling up voluntary medical MC (VMMC) should obtain physical-exam-based MC data to guide service delivery and cost estimates. HIV prevention messages promoting VMMC should provide comprehensive education regarding the definition of VMMC. C1 [Thomas, Anne Goldzier; Tran, Bonnie Robin] USN, Dept Def HIV AIDS Prevent Program, Hlth Res Ctr, San Diego, CA 92132 USA. [Cranston, Marcus] USAF, Dept Def, Keesler AFB, MS USA. [Brown, Malerato Cecilia] US Embassy, US Presidents Emergency Plan AIDS Relif Lesotho, Maseru, Lesotho. [Kumar, Rajiv] Indian Armed Forces, Pune, Maharashtra, India. [Tlelai, Matsotetsi] Lesotho Def Force, Maseru, Lesotho. RP Thomas, AG (reprint author), USN, Dept Def HIV AIDS Prevent Program, Hlth Res Ctr, San Diego, CA 92132 USA. EM anne.thomas@med.navy.mil FU PEPFAR FX Our program is supported by PEPFAR. DoD/DHAPP is a USG PEPFAR implementing agency. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, or the U. S. Government. NR 26 TC 16 Z9 16 U1 0 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 29 PY 2011 VL 6 IS 11 AR e27561 DI 10.1371/journal.pone.0027561 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 863LT UT WOS:000298166300006 PM 22140449 ER PT J AU Pang, VO Han, PP Pang, JM AF Pang, Valerie Ooka Han, Peggy P. Pang, Jennifer M. TI Asian American and Pacific Islander Students: Equity and the Achievement Gap SO EDUCATIONAL RESEARCHER LA English DT Article DE achievement gap; ANOVA; Asian American education; correlational analysis; equity ID MATHEMATICS EDUCATION; ACADEMIC-ACHIEVEMENT; RACE; FILIPINO; CHILDREN; MODEL; PERFORMANCE; ADOLESCENTS; CURRICULUM; RESPONSES AB The authors studied more than 1 million Asian American and Pacific Islander (AAPI) and White seventh graders in a statewide California testing program between 2003 and 2008, examining their reading and math achievement. AAPI student performance is often reported as an aggregate in discussions of the success of schoolchildren and issues of racial and ethnic achievement gaps. The authors disaggregated the performance of 13 AAPI subgroups and found significant achievement gaps between White Americans and their AAPI peers in reading and math. The data refuted the premise of the model minority myth. The evidence indicated that AAPI students are diverse in their achievements and demonstrate a continuum of academic performance. C1 [Pang, Valerie Ooka] San Diego State Univ, Coll Educ, San Diego, CA 92182 USA. [Han, Peggy P.] USN, Hlth Res Ctr, Dept Med Modeling Simulat & Mission Support, San Diego, CA 92106 USA. [Pang, Jennifer M.] Seattle Biomed Res Inst, Seattle, WA 98109 USA. RP Pang, VO (reprint author), San Diego State Univ, Coll Educ, 5500 Campanile Dr, San Diego, CA 92182 USA. EM pang@mail.sdsu.edu; peggyhan.dataanalyst@gmail.com; seattlejennpang@gmail.com NR 72 TC 11 Z9 11 U1 0 U2 11 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0013-189X J9 EDUC RESEARCHER JI Educ. Researcher PD NOV PY 2011 VL 40 IS 8 BP 378 EP 389 DI 10.3102/0013189X11424222 PG 12 WC Education & Educational Research SC Education & Educational Research GA 889YW UT WOS:000300113200002 ER PT J AU Edgil, D Stankard, P Forsythe, S Rech, D Chrouser, K Adamu, T Sakallah, S Thomas, AG Albertini, J Stanton, D Dickson, KE Njeuhmeli, E AF Edgil, Dianna Stankard, Petra Forsythe, Steven Rech, Dino Chrouser, Kristin Adamu, Tigistu Sakallah, Sameer Thomas, Anne Goldzier Albertini, Jennifer Stanton, David Dickson, Kim Eva Njeuhmeli, Emmanuel TI Voluntary Medical Male Circumcision: Logistics, Commodities, and Waste Management Requirements for Scale-Up of Services SO PLOS MEDICINE LA English DT Article ID HIV PREVENTION; TRIAL; MEN AB Background: The global HIV prevention community is implementing voluntary medical male circumcision (VMMC) programs across eastern and southern Africa, with a goal of reaching 80% coverage in adult males by 2015. Successful implementation will depend on the accessibility of commodities essential for VMMC programming and the appropriate allocation of resources to support the VMMC supply chain. For this, the United States President's Emergency Plan for AIDS Relief, in collaboration with the World Health Organization and the Joint United Nations Programme on HIV/AIDS, has developed a standard list of commodities for VMMC programs. Methods and Findings: This list of commodities was used to inform program planning for a 1-y program to circumcise 152,000 adult men in Swaziland. During this process, additional key commodities were identified, expanding the standard list to include commodities for waste management, HIV counseling and testing, and the treatment of sexually transmitted infections. The approximate costs for the procurement of commodities, management of a supply chain, and waste disposal, were determined for the VMMC program in Swaziland using current market prices of goods and services. Previous costing studies of VMMC programs did not capture supply chain costs, nor the full range of commodities needed for VMMC program implementation or waste management. Our calculations indicate that depending upon the volume of services provided, supply chain and waste management, including commodities and associated labor, contribute between US$58.92 and US$73.57 to the cost of performing one adult male circumcision in Swaziland. Conclusions: Experience with the VMMC program in Swaziland indicates that supply chain and waste management add approximately US$60 per circumcision, nearly doubling the total per procedure cost estimated previously; these additional costs are used to inform the estimate of per procedure costs modeled by Njeuhmeli et al. in "Voluntary Medical Male Circumcision: Modeling the Impact and Cost of Expanding Male Circumcision for HIV Prevention in Eastern and Southern Africa." Program planners and policy makers should consider the significant contribution of supply chain and waste management to VMMC program costs as they determine future resource needs for VMMC programs. C1 [Edgil, Dianna; Stanton, David; Njeuhmeli, Emmanuel] US Agcy Int Dev, Washington, DC 20523 USA. [Stankard, Petra] Univ N Carolina, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. [Forsythe, Steven] Futures Inst, Glastonbury, CT USA. [Rech, Dino] Ctr HIV & AIDS Prevent Studies, Johannesburg, South Africa. [Chrouser, Kristin; Adamu, Tigistu] Jhpiego, Baltimore, MD USA. [Sakallah, Sameer] Supply Chain Management Syst, Arlington, VA USA. [Thomas, Anne Goldzier] USN, Dept Def HIV AIDS Prevent Program, Hlth Res Ctr, San Diego, CA 92152 USA. [Albertini, Jennifer] US Agcy Int Dev, Mbabane, Swaziland. [Dickson, Kim Eva] WHO, CH-1211 Geneva, Switzerland. RP Edgil, D (reprint author), US Agcy Int Dev, Washington, DC 20523 USA. EM dedgil@usaid.gov FU United States Agency for International Development (USAID) FX Funding for the execution of this costing analysis was provided by PEPFAR through The Partnership for Supply Chain Management Project (SCMS) and Health Policy Initiative Costing Task Order (HPI CO TO) both funded by the United States Agency for International Development (USAID). Technical staff from USAID, US Centers for Disease Control and Prevention, and US Department of Defense was involved in study design, data collection and analysis, decision to publish, and preparation of the manuscript. NR 16 TC 13 Z9 13 U1 1 U2 12 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1549-1277 J9 PLOS MED JI PLos Med. PD NOV PY 2011 VL 8 IS 11 AR e1001128 DI 10.1371/journal.pmed.1001128 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA 862ZR UT WOS:000298133100014 PM 22140363 ER PT J AU Conway, TL Hammer, PS Galarneau, MR Larson, GE Edwards, NK Schmied, EA Ly, HL Schmitz, KJ Webb-Murphy, JA Boucher, WC Johnson, DC Ghaed, SG AF Conway, Terry L. Hammer, Paul S. Galarneau, Michael R. Larson, Gerald E. Edwards, Nathan K. Schmied, Emily A. Ly, Hoa L. Schmitz, Kimberly J. Webb-Murphy, Jennifer A. Boucher, Wayne C. Johnson, Douglas C. Ghaed, Shiva G. TI Theater Mental Health Encounter Data (TMHED): Overview of Study Design and Methods SO MILITARY MEDICINE LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; TRAUMATIC BRAIN-INJURY; US MILITARY COHORT; PSYCHIATRIC-DISORDERS; WAR VETERANS; IRAQ; DEPLOYMENT; CARE; AFGHANISTAN; SYMPTOMS AB Research has documented higher risks for mental health problems among service members deployed to war zones, yet a research limitation has been that assessment has generally occurred often years after combat exposure. The Operational Stress Control and Readiness program integrated mental health practitioners with 1st Marine Division units serving in Iraq. This team documented mental health visits between January 2006 and January 2007 and developed the Theater Mental Health Encounter Database (TMHED). This report describes the TMHED study design, measures, and cases. Of I,336 patients (3,180 patient visits), 10% were women, 75% were high school educated, 55% were mid-paygrade enlisted, and 63% were on their first combat deployment. Compared with the overall deployed population, patient percentages included higher percentages of Marines and Navy personnel but lower percentages of Army and Air Force personnel, more junior enlisted but fewer officers, and fewer college graduates. TMHED provides an unprecedented opportunity to study early psychiatric intervention in a combat zone and prospectively examines postdeployment health and career outcomes. C1 [Conway, Terry L.; Galarneau, Michael R.; Larson, Gerald E.; Edwards, Nathan K.; Schmied, Emily A.; Ly, Hoa L.; Johnson, Douglas C.] USN, Hlth Res Ctr, San Diego, CA 92106 USA. [Hammer, Paul S.; Schmitz, Kimberly J.; Webb-Murphy, Jennifer A.; Ghaed, Shiva G.] USN, San Diego Med Ctr, NCCOSC, San Diego, CA 92134 USA. [Boucher, Wayne C.] OSCAR Program, Div Surgeon Off, Marine Div 1, Camp Pendleton, CA 92055 USA. RP Conway, TL (reprint author), USN, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. FU U.S. Department of Defense, Bureau of Medicine under NHRC Work Unit [60812, 60819] FX The authors thank James Zouris for providing the population parameters for U.S. service personnel deployed in the Iraqi combat theater during the study's time frame. This work was supported in part by the U.S. Department of Defense, Bureau of Medicine, under NHRC Work Unit Numbers 60812 and 60819. NR 20 TC 2 Z9 2 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2011 VL 176 IS 11 BP 1243 EP 1252 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA 845NR UT WOS:000296830300007 PM 22165651 ER PT J AU Myers, CA Kasper, MR Yasuda, CY Savuth, C Spiro, DJ Halpin, R Faix, DJ Coon, R Putnam, SD Wierzba, TF Blair, PJ AF Myers, Christopher A. Kasper, Matthew R. Yasuda, Chadwick Y. Savuth, Chin Spiro, David J. Halpin, Rebecca Faix, Dennis J. Coon, Robert Putnam, Shannon D. Wierzba, Thomas F. Blair, Patrick J. TI Short Report: Dual Infection of Novel Influenza Viruses A/H1N1 and A/H3N2 in a Cluster of Cambodian Patients SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID PANDEMIC H1N1 2009; H3N2 VIRUSES; ORIGIN; REASSORTMENT; SWINE; IDENTIFICATION; COINFECTION; HUMANS; GENOME AB During the early months of 2009, a novel influenza A/H1N1 virus (pH1N1) emerged in Mexico and quickly spread across the globe. In October 2009, a 23-year-old male residing in central Cambodia was diagnosed with pH1N1. Subsequently, a cluster of four influenza-like illness cases developed involving three children who resided in his home and the children's school teacher. Base composition analysis of internal genes using reverse transcriptase polymerase chain reaction and electrospray ionization mass spectrometry revealed that specimens from two of the secondary victims were coinfected with influenza A/H3N2 and pH1N1. Phylogenetic analysis of the hemagglutinin genes from these isolated viruses showed that they were closely related to existing pH1N1 and A/H3N2 viruses circulating in the region. Genetic recombination was not evident within plaque-purified viral isolates on full genome sequencing. This incident confirms dual influenza virus infections and highlights the risk of zoonotic and seasonal influenza viruses to coinfect and possibly, reassort where they cocirculate. C1 [Blair, Patrick J.] USN, Hlth Res Ctr, Dept Resp Dis, San Diego, CA 92106 USA. [Kasper, Matthew R.; Yasuda, Chadwick Y.; Putnam, Shannon D.; Wierzba, Thomas F.; Blair, Patrick J.] USN, Med Res Unit 2, Phnom Penh, Cambodia. [Savuth, Chin] Minist Hlth, Natl Inst Publ Hlth, Phnom Penh, Cambodia. [Spiro, David J.; Halpin, Rebecca] J Craig Venter Inst, Rockville, MD USA. RP Blair, PJ (reprint author), USN, Hlth Res Ctr, Dept Resp Dis, 140 Sylvester Rd, San Diego, CA 92106 USA. EM Chris.Myers2@med.navy.mil; Matthew.Kasper@med.navy.mil; Chad@namru2.org.kh; savuth_chin@yahoo.com; david.spiro@nih.gov; rhalpin@jcvi.org; dennis.faix@med.navy.mil; robert.coon@med.navy.mil; shan.putnam@med.navy.mil; twierzba@IVI.int; patrick.blair@med.navy.mil RI Valle, Ruben/A-7512-2013 FU US Department of Defense Armed Forces Health Surveillance Center division of the Global Emerging Infections Surveillance and Response System (AFHSC/GEIS); US Defense Advanced Research Projects Agency, (DARPA) [60941]; National Institute of Allergy and Infectious Diseases, National Institute of Health, Department of Health and Human Services [HHSN272200900007C] FX This work was funded in part by grants from the US Department of Defense Armed Forces Health Surveillance Center division of the Global Emerging Infections Surveillance and Response System (AFHSC/GEIS) and the US Defense Advanced Research Projects Agency, (DARPA) under work unit number 60941. A portion of this project was funded by the National Institute of Allergy and Infectious Diseases, National Institute of Health, Department of Health and Human Services under contract number HHSN272200900007C. NR 21 TC 8 Z9 9 U1 0 U2 7 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2011 VL 85 IS 5 BP 961 EP 963 DI 10.4269/ajtmh.2011.11-0098 PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 843HC UT WOS:000296661900032 PM 22049058 ER PT J AU Lanthier, PA Huston, GE Moquin, A Eaton, SM Szaba, FM Kummer, LW Tighe, MP Kohlmeier, JE Blair, PJ Broderick, M Smiley, ST Haynes, L AF Lanthier, Paula A. Huston, Gail E. Moquin, Amy Eaton, Sheri M. Szaba, Frank M. Kummer, Lawrence W. Tighe, Micheal P. Kohlmeier, Jacob E. Blair, Patrick J. Broderick, Michael Smiley, Stephen T. Haynes, Laura TI Live attenuated influenza vaccine (LAIV) impacts innate and adaptive immune responses SO VACCINE LA English DT Article DE Influenza; Vaccination; Heterosubtypic; LAW ID T-CELL RESPONSE; A-VIRUS; HETEROSUBTYPIC IMMUNITY; HETEROTYPIC IMMUNITY; DENDRITIC CELLS; GM-CSF; INFECTION; MICE; LYMPHOCYTES; TYPE-1 AB Influenza A infection induces a massive inflammatory response in the lungs that leads to significant illness and increases the susceptibility to secondary bacterial pneumonia. The most efficient way to prevent influenza infection is through vaccination. While inactivated vaccines induce protective levels of serum antibodies to influenza hemaglutinin (HA) and neuraminidase (NA) surface proteins, these are strain specific and offer little protection against heterosubtypic influenza viruses. In contrast, live attenuated influenza vaccines (LAIVs) induce a T cell response in addition to antibody responses against HA and NA surface proteins. Importantly, LAIV vaccination induces a response in a mouse model that protects against illness due to heterosubtypic influenza strains. While it is not completely clear what is the mechanism of action of LAIV heterosubtypic protection in humans, it has been shown that LAIV induces heterosubtypic protection in mice that is dependent upon a Type 1 immune response and requires CD8 T cells. In this study, we show that LAIV-induced immunity leads to significantly reduced viral titers and inflammatory responses in the lungs of mice following heterosubtypic infection. Not only are viral titers reduced in LAIV vaccinated mice, the amounts of inflammatory cytokines and chemokines in lung tissue are significantly lower. Additionally, we show that LAIV vaccination of healthy adults also induces a robust Type 1 memory response including the production of chemokines and cytokines involved in T cell activation and recruitment. Thus, our results indicate that LAIV vaccination functions by inducing immune memory which can act to modulate the immune response to subsequent heterosubtypic challenge by influencing both innate and adaptive responses. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Lanthier, Paula A.; Huston, Gail E.; Moquin, Amy; Eaton, Sheri M.; Szaba, Frank M.; Kummer, Lawrence W.; Tighe, Micheal P.; Kohlmeier, Jacob E.; Smiley, Stephen T.; Haynes, Laura] Trudeau Inst Inc, Saranac Lake, NY 12983 USA. [Blair, Patrick J.; Broderick, Michael] USN, Resp Dis Res Dept, Hlth Res Ctr, San Diego, CA 92106 USA. RP Haynes, L (reprint author), Trudeau Inst Inc, 154 Algonquin Ave, Saranac Lake, NY 12983 USA. EM lhaynes@trudeauinstitute.org RI Valle, Ruben/A-7512-2013 FU Department of Defense [W911QY-09-C-0014] FX This project was funded by Department of Defense contract W911QY-09-C-0014. We would like to thank Dr. Larry Johnson for assistance with statistical analysis and Dr. Brian Murphy for providing the c.a.A/Alaska/72/CR9 virus. NR 37 TC 28 Z9 28 U1 0 U2 17 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD OCT 13 PY 2011 VL 29 IS 44 BP 7849 EP 7856 DI 10.1016/j.vaccine.2011.07.093 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 841WW UT WOS:000296546900044 PM 21816194 ER PT J AU Leleu, TD Jacobson, IG LeardMann, CA Smith, B Foltz, PW Amoroso, PJ Derr, MA Ryan, MAK Smith, TC AF Leleu, Travis D. Jacobson, Isabel G. LeardMann, Cynthia A. Smith, Besa Foltz, Peter W. Amoroso, Paul J. Derr, Marcia A. Ryan, Margaret A. K. Smith, Tyler C. CA Millennium Cohort Study Team TI Application of latent semantic analysis for open-ended responses in a large, epidemiologic study SO BMC MEDICAL RESEARCH METHODOLOGY LA English DT Article ID MILLENNIUM COHORT; MILITARY SERVICE; US MILITARY; HEALTH; VACCINATION; PREVALENCE; VALIDATION; ENROLLMENT; CARE AB Background: The Millennium Cohort Study is a longitudinal cohort study designed in the late 1990s to evaluate how military service may affect long-term health. The purpose of this investigation was to examine characteristics of Millennium Cohort Study participants who responded to the open-ended question, and to identify and investigate the most commonly reported areas of concern. Methods: Participants who responded during the 2001-2003 and 2004-2006 questionnaire cycles were included in this study (n = 108,129). To perform these analyses, Latent Semantic Analysis (LSA) was applied to a broad open-ended question asking the participant if there were any additional health concerns. Multivariable logistic regression was performed to examine the adjusted odds of responding to the open-text field, and cluster analysis was executed to understand the major areas of concern for participants providing open-ended responses. Results: Participants who provided information in the open-ended text field (n = 27,916), had significantly lower self-reported general health compared with those who did not provide information in the open-ended text field. The bulk of responses concerned a finite number of topics, most notably illness/injury, exposure, and exercise. Conclusion: These findings suggest generalized topic areas, as well as identify subgroups who are more likely to provide additional information in their response that may add insight into future epidemiologic and military research. C1 [Leleu, Travis D.; Jacobson, Isabel G.; LeardMann, Cynthia A.; Smith, Besa; Smith, Tyler C.] USN, Hlth Res Ctr, Deployment Hlth Res Dept, San Diego, CA 92106 USA. [Amoroso, Paul J.] 2MultiCare Res Inst, Tacoma, WA 98415 USA. [Foltz, Peter W.; Derr, Marcia A.] Pearson Knowledge Technol, Boulder, CO 80301 USA. [Ryan, Margaret A. K.] Naval Hosp Camp Pendleton, Camp Pendleton, CA 92055 USA. RP Jacobson, IG (reprint author), USN, Hlth Res Ctr, Deployment Hlth Res Dept, 140 Sylvester Rd, San Diego, CA 92106 USA. EM isabel.jacobson@med.navy.mil FU Department of Defense [60002]; US Army Medical Research and Materiel Command, Fort Detrick, Maryland; Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, MD FX This research represents Naval Health Research Center report 10-08, supported by the Department of Defense, under work unit no. 60002 and has been conducted in compliance with all applicable federal regulations governing the protection of human subjects in research (Protocol NHRC.2000.0007). Financial support: The Millennium Cohort Study is funded through the Military Operational Medicine Research Program of the US Army Medical Research and Materiel Command, Fort Detrick, Maryland. The funding organization had no role in the design and conduct of the study; collection, analysis, or preparation of data; or preparation, review, or approval of the manuscript.; The authors would like to thank Scott L. Seggerman from the Management Information Division, US Defense Manpower Data Center, Monterey, CA; Michelle LeWark from the Naval Health Research Center; and all the professionals from the US Army Medical Research and Materiel Command, especially those from the Military Operational Medicine Research Program, Fort Detrick, MD. We appreciate the support of the Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, MD. In addition to the authors, the Millennium Cohort Study team includes Melissa Bagnell, Gia Gumbs, Nisara Granado, Dennis Hernando, Jamie Horton, Kelly Jones, Lauren Kipp, William Lee, Amanda Pietrucha, Teresa Powell, Amber Seelig, Katherine Snell, Steven Speigle, Kari Sausedo, Beverly Sheppard, Martin White, James Whitmer, and Charlene Wong, from the Deployment Health Research Department, Naval Health Research Center, San Diego, CA; Edward J Boyko, from the Seattle Epidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA; Gary D. Gackstetter, from the Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD, and Analytic Services Inc. (ANSER), Arlington, VA; Gregory C. Gray, from the College of Public Health and Health Professions, University of Florida, Gainesville, FL; Tomoko I. Hooper, from the Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD; James R. Riddle; and Timothy S. Wells from the Naval Health Research Center, San Diego, CA. NR 25 TC 1 Z9 1 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2288 J9 BMC MED RES METHODOL JI BMC Med. Res. Methodol. PD OCT 5 PY 2011 VL 11 AR 136 DI 10.1186/1471-2288-11-136 PG 11 WC Health Care Sciences & Services SC Health Care Sciences & Services GA 839LK UT WOS:000296367000003 PM 21974837 ER PT J AU Broderick, MP Hansen, CJ Russell, KL Kaplan, EL Blumer, JL Faix, DJ AF Broderick, Michael P. Hansen, Christian J. Russell, Kevin L. Kaplan, Edward L. Blumer, Jeffrey L. Faix, Dennis J. TI Serum Penicillin G Levels Are Lower Than Expected in Adults within Two Weeks of Administration of 1.2 Million Units SO PLOS ONE LA English DT Article ID GROUP-A STREPTOCOCCI; RHEUMATIC-FEVER; BENZATHINE; PHARYNGITIS; PREVENTION AB When introduced in the 1950s, benzathine penicillin G (BPG) was shown to be effective in eradicating group A beta-hemolytic streptococcus (GAS) for at least 3 weeks after administration. Several studies since the 1990s suggest that at 3-4 weeks serum penicillin G levels are less than adequate (below MIC 90 of 0.016 mg/ml). We studied these levels for 4 weeks after the recommended dose of BPG in military recruits, for whom it is used as prophylaxis against GAS. The 329 subjects (mean age 20 years) each received 1.2 million units BPG IM and gave sera 1 day post injection and twice more at staggered time points over 4 weeks. Serum penicillin G levels were measured by liquid chromatography/tandem mass spectometry. The half-life of serum penicillin G was 4.1 days. By day 11, mean levels were, <0.02 mu g/ml, and by day 15<0.01 mu g/ml. Levels in more than 50% of the subjects were below 0.02 mu g/ml on day 9, and, <.01 mg/ml on day 16. There was no demonstrable effect of subject body-surface area nor of the four different lots of BPG used. These data indicate that in healthy young adults serum penicillin G levels become less than protective <21/2 weeks after injection of 1.2 million units of BPG. The findings require serious consideration in future medical and public health recommendations for treatment and prophylaxis of GAS upper respiratory tract infections. C1 [Broderick, Michael P.; Hansen, Christian J.] USN, Henry M Jackson Fdn Adv Mil Med, Hlth Res Ctr, San Diego, CA 92152 USA. [Russell, Kevin L.] US Dept Def Global Emerging Infect Surveillance &, Silver Spring, MD USA. [Kaplan, Edward L.] Univ Minnesota, Sch Med, Dept Pediat, Minneapolis, MN 55455 USA. [Blumer, Jeffrey L.] Case Western Reserve Univ, Sch Med, Dept Pediat & Pharmacol, Cleveland, OH USA. RP Broderick, MP (reprint author), USN, Henry M Jackson Fdn Adv Mil Med, Hlth Res Ctr, San Diego, CA 92152 USA. EM michael.broderick@med.navy.mil RI Valle, Ruben/A-7512-2013 FU Department of Defense Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center [60501] FX This work was supported by the Department of Defense Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center, WU# 60501, http://afhsc.mil/geis. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 17 TC 4 Z9 4 U1 1 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD OCT 4 PY 2011 VL 6 IS 10 AR e25308 DI 10.1371/journal.pone.0025308 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 834MB UT WOS:000295963300009 PM 21991307 ER PT J AU Porter, C Faix, D Shiau, D Espiritu, J Espinosa, B Riddle, M AF Porter, Chad Faix, Dennis Shiau, Daniel Espiritu, Jennifer Espinosa, Benjamin Riddle, Mark TI A Case Control Study of Post Infectious Sequelae Following Outbreaks of Norovirus in US Military Populations SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 76th Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 28-NOV 02, 2011 CL Washington, DC SP Amer Coll Gastroenterol C1 [Porter, Chad; Riddle, Mark] USN, Med Res Ctr, Silver Spring, MD USA. [Faix, Dennis] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Shiau, Daniel] USN, Bur Med & Surg, Washington, DC USA. [Espiritu, Jennifer; Espinosa, Benjamin] USN, Environm & Prevent Med Unit 2, Norfolk, VA USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2011 VL 106 SU 2 MA 1338 BP S512 EP S513 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 885II UT WOS:000299772002181 ER PT J AU Thomsen, CJ Stander, VA McWhorter, SK Rabenhorst, MM Milner, JS AF Thomsen, Cynthia J. Stander, Valerie A. McWhorter, Stephanie K. Rabenhorst, Mandy M. Milner, Joel S. TI Effects of combat deployment on risky and self-destructive behavior among active duty military personnel SO JOURNAL OF PSYCHIATRIC RESEARCH LA English DT Article DE Combat deployment; Self-harm; Suicide attempts; Illegal drugs; Risk-taking; Unprotected sex; Depression; Anxiety; PTSD ID ARMED-FORCES PERSONNEL; MENTAL-HEALTH PROBLEMS; ALCOHOL-USE; POSTTRAUMATIC-STRESS; SENSATION SEEKING; INJURY PREVENTION; VIETNAM VETERANS; PERSIAN-GULF; YOUNG-ADULTS; FOLLOW-UP AB Although research has documented negative effects of combat deployment on mental health, few studies have examined whether deployment increases risky or self-destructive behavior. The present study addressed this issue. In addition, we examined whether deployment effects on risky behavior varied depending on history of pre-deployment risky behavior, and assessed whether psychiatric conditions mediated effects of deployment on risky behavior. In an anonymous survey, active duty members of the U.S. Marine Corps and U.S. Navy (N = 2116) described their deployment experiences and their participation in risky recreational activities, unprotected sex, illegal drug use, self-injurious behavior, and suicide attempts during three time frames (civilian, military pre-deployment, and military post-deployment). Respondents also reported whether they had problems with depression, anxiety, or PTSD during the same three time frames. Results revealed that risky behavior was much more common in civilian than in military life, with personnel who had not deployed, compared to those who had deployed, reporting more risky behavior and more psychiatric problems as civilians. For the current time period, in contrast, personnel who had deployed (versus never deployed) were significantly more likely to report both risky behavior and psychiatric problems. Importantly, deployment was associated with increases in risky behavior only for personnel with a pre-deployment history of engaging in risky behavior. Although psychiatric conditions were associated with higher levels of risky behavior, psychiatric problems did not mediate associations between deployment and risky behavior. Implications for understanding effects of combat deployment on active duty personnel and directions for future research are discussed. Published by Elsevier Ltd. C1 [Thomsen, Cynthia J.; Stander, Valerie A.; McWhorter, Stephanie K.] Naval Hlth Res Ctr, San Diego, CA 92106 USA. [Rabenhorst, Mandy M.; Milner, Joel S.] No Illinois Univ, Ctr Study Family Violence & Sexual Assault, De Kalb, IL 60640 USA. RP Thomsen, CJ (reprint author), Naval Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. EM cynthia.thomsen@med.navy.mil FU Office of Prevention and Intervention (OPI), Headquarters Marine Corps, Manpower [60202] FX Funding for this study was provided by the Office of Prevention and Intervention (OPI), Headquarters Marine Corps, Manpower, under Work Unit No. 60202. The OPI had no further role in study design; in the collection, analysis, or interpretation of data; or in the writing of the report. However, OPI personnel reviewed this manuscript and approved its release for publication. NR 56 TC 19 Z9 19 U1 3 U2 14 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-3956 J9 J PSYCHIATR RES JI J. Psychiatr. Res. PD OCT PY 2011 VL 45 IS 10 BP 1321 EP 1331 DI 10.1016/j.jpsychires.2011.04.003 PG 11 WC Psychiatry SC Psychiatry GA 834XT UT WOS:000295998500007 PM 21549392 ER PT J AU Macera, CA Aralis, HJ MacGregor, AJ Rauh, MJ Han, PP Galarneau, MR AF Macera, Caroline A. Aralis, Hilary J. MacGregor, Andrew J. Rauh, Mitchell J. Han, Peggy P. Galarneau, Michael R. TI Cigarette Smoking, Body Mass Index, and Physical Fitness Changes Among Male Navy Personnel SO NICOTINE & TOBACCO RESEARCH LA English DT Article ID MILITARY PERSONNEL; US-ARMY; DEPLOYMENT; WEIGHT; LIFE; BMI AB Introduction: Cigarette smoking has been reported to be higher among deployed military men than among similarly aged civilian or nondeployed men, but the short-term effect of smoking on physical fitness among these young healthy men is unclear. This study examined self-reported smoking status and change in objectively measured fitness over 1-4 years while controlling for body mass index (BMI). Methods: This study included a large sample of male U. S. navy personnel who deployed to Iraq or Kuwait between 2005 and 2008. A mixed modeling procedure was used to determine factors contributing to longitudinal changes in both BMI and fitness (measured by run/walk times, curl-ups, and push-ups). Results: Of the total sample (n = 18,537), the 20% current smokers were more likely than nonsmokers to be enlisted, younger, and have lower BMI measurements at baseline. In addition, smokers had slower 1.5-mile run/walk times and could do fewer curl-ups and push-ups compared with nonsmokers. The run/walk time model indicated that over 4 years, smokers (compared with nonsmokers) experienced a significantly greater rate of decrease in cardiorespiratory fitness, even after controlling for changes in BMI. Conclusions: These results call for continued attention to the problem of nicotine use among young healthy men. C1 [Macera, Caroline A.; Aralis, Hilary J.; Rauh, Mitchell J.] USN, Warfighter Performance Dept, Hlth Res Ctr, San Diego, CA 92106 USA. [MacGregor, Andrew J.; Han, Peggy P.; Galarneau, Michael R.] USN, Med Modeling Simulat & Mission Support Dept, Hlth Res Ctr, San Diego, CA 92106 USA. RP Aralis, HJ (reprint author), USN, Warfighter Performance Dept, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. EM hilary.aralis@med.navy.mil FU U.S. Navy Bureau of Medicine and Surgery, Washington, DC [60332] FX This work was supported by the U.S. Navy Bureau of Medicine and Surgery, Washington, DC, under Work Unit No. 60332. NR 17 TC 10 Z9 10 U1 0 U2 5 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1462-2203 J9 NICOTINE TOB RES JI Nicotine Tob. Res. PD OCT PY 2011 VL 13 IS 10 BP 965 EP 971 DI 10.1093/ntr/ntr104 PG 7 WC Substance Abuse; Public, Environmental & Occupational Health SC Substance Abuse; Public, Environmental & Occupational Health GA 828NL UT WOS:000295508500010 PM 21624940 ER PT J AU Rau, TJ Merrill, LL McWhorter, SK Stander, VA Thomsen, CJ Dyslin, CW Crouch, JL Rabenhorst, MM Milner, JS AF Rau, Terri J. Merrill, Lex L. McWhorter, Stephanie K. Stander, Valerie A. Thomsen, Cynthia J. Dyslin, Christopher W. Crouch, Julie L. Rabenhorst, Mandy M. Milner, Joel S. TI Evaluation of a Sexual Assault Education/Prevention Program for Female US Navy Personnel SO MILITARY MEDICINE LA English DT Article ID EXPERIENCES SURVEY; RECRUIT SAMPLE; RAPE; VICTIMIZATION; AGGRESSION; PREVALENCE; PREVENTION; VALIDITY AB The U.S. Navy Sexual Assault Intervention Training (SAIT) program for women was evaluated in a randomized clinical trial. The SALT uses multiple presentation modalities (lecture, slides, discussion, film) to provide information related to sexual assault, including risk factors, consequences, prevention, and relevant military regulations. Female personnel who had completed basic training (N = 550) participated in the SALT or a Comparison condition, and then completed measures of rape knowledge, empathy for rape victims, and acceptance of rape myths (false beliefs about rape justifying sexual violence). Results showed that the SAIT increased factual knowledge about rape. In addition, the SAIT increased empathy with rape victims in some groups of women. However, the program did not reduce women's rape myth acceptance. Given the enormity of the problem of sexual assault and these promising initial findings, additional research on the efficacy of the SAIT is clearly warranted. C1 [Rau, Terri J.] Millington Detachment, Navy Fleet & Family Support Program, Navy Installat Command, Res Dev & Performance Management, Millington, TN 38055 USA. [Merrill, Lex L.; McWhorter, Stephanie K.; Stander, Valerie A.] USN, Behav Sci & Epidemiol Dept, Hlth Res Ctr, San Diego, CA 92106 USA. [Thomsen, Cynthia J.; Crouch, Julie L.; Rabenhorst, Mandy M.; Milner, Joel S.] No Illinois Univ, Ctr Study Family Violence & Sexual Assault, Dept Psychol, De Kalb, IL 60115 USA. [Dyslin, Christopher W.] Governors State Univ, Div Psychol & Counseling, University Pk, IL 60466 USA. RP Rau, TJ (reprint author), Millington Detachment, Navy Fleet & Family Support Program, Navy Installat Command, Res Dev & Performance Management, 5720 Integr Dr, Millington, TN 38055 USA. FU Personnel Support Department [N2, 6309] FX The Naval Health Research Center Report No. 09-10 was supported by the Fleet and Family Support Programs, Personnel Support Department (N2), Commander, Navy Installations, under Work Unit No. 6309. NR 20 TC 4 Z9 4 U1 3 U2 20 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2011 VL 176 IS 10 BP 1178 EP 1183 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 831EK UT WOS:000295711300018 PM 22128655 ER PT J AU Stemper, BD Yoganandan, N Paskoff, GR Fijalkowski, RJ Storvik, SG Baisden, JL Pintar, FA Shender, BS AF Stemper, B. D. Yoganandan, N. Paskoff, G. R. Fijalkowski, R. J. Storvik, S. G. Baisden, J. L. Pintar, F. A. Shender, B. S. TI Thoracolumbar spine trauma in military environments SO MINERVA ORTOPEDICA E TRAUMATOLOGICA LA English DT Article DE Lumbar vertebrae; Spinal injuries; Blast injuries; Biomechanics ID MOTOR-VEHICLE CRASHES; QUANTITATIVE COMPUTED-TOMOGRAPHY; ARMY HELICOPTER CRASHES; HUMAN LUMBAR VERTEBRAE; BURST FRACTURES; AIR-FORCE; COMPRESSIVE STRENGTH; EJECTION EXPERIENCE; INTERVERTEBRAL JOINT; LOADING RATE AB With increasing reports of traumas in ongoing wars around the world, it is important to delineate the spectrum and associated clinical biomechanics of spinal injuries in military environments. Ejections, helicopter crashes, and underbody blast loadings constitute the most common modes of injuries to this region of the human body. The purpose of this paper is to analyze clinical, descriptive, and biomechanical studies in these areas. While ejection-related injuries occur to the entire vertebral column, helicopter crash and underbody blast-related injuries are biased towards the dorsal region. Injuries are focused in the mid-thoracic areas for ejection and in the middle regions of the lumbar spine for the higher-rate loading scenarios. These patterns indicate that the primary mode of external load transmission, as well as rate at which the loading is applied, affect injury distributions within the anatomical structure. These distributions contrast civilian populations wherein the thoracolumbar junction is the most vulnerable region for acute trauma. Important biomechanical factors affecting trauma included loading rate, dynamic load level, occupant anthropometry, and posture/alignment with respect to the loading vector at the time of the transmission of the external load. The changing injury patterns resulting in caudal migration for underbody blast and rostral migration for ejection loadings may have implications in the treatment regimen. C1 [Stemper, B. D.; Yoganandan, N.; Fijalkowski, R. J.; Storvik, S. G.; Baisden, J. L.; Pintar, F. A.] Med Coll Wisconsin, Dept Neurosurg, Milwaukee, WI 53226 USA. [Paskoff, G. R.; Shender, B. S.] USN, Div Aircraft, Air Warfare Ctr, Patuxent River, MD USA. RP Stemper, BD (reprint author), 5000 W Natl Ave,Res 151, Milwaukee, WI 53072 USA. EM bstemper@mcw.edu OI Storvik, Steven/0000-0002-6741-3198 FU Office of Naval and Veterans Affairs Medical Research through Naval Air Warfare Center Aircraft Division [N00421-10-0049] FX This research was supported in part by the Office of Naval and Veterans Affairs Medical Research through Naval Air Warfare Center Aircraft Division Contract N00421-10-0049. NR 106 TC 4 Z9 4 U1 2 U2 5 PU EDIZIONI MINERVA MEDICA PI TURIN PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY SN 0026-4911 J9 MINERVA ORTOP TRAUMA JI Minerva Ortop. Traumatol. PD OCT PY 2011 VL 62 IS 5 BP 397 EP 412 PG 16 WC Orthopedics SC Orthopedics GA 832PF UT WOS:000295816600009 ER PT J AU Burgi, AA Gorham, ED Garland, CF Mohr, SB Garland, FC Zeng, K Thompson, K Lappe, JM AF Burgi, Alina A. Gorham, Edward D. Garland, Cedric F. Mohr, Sharif B. Garland, Frank C. Zeng, Kenneth Thompson, Kerry Lappe, Joan M. TI High Serum 25-Hydroxyvitamin D Is Associated With a Low Incidence of Stress Fractures SO JOURNAL OF BONE AND MINERAL RESEARCH LA English DT Article DE SERUM 25-HYDROXYVITAMIN D; VITAMIN D; STRESS FRACTURE; BONE; PHYSICAL TRAINING ID VITAMIN-D SUPPLEMENTATION; ELEVATED PARATHYROID-HORMONE; FEMALE ARMY RECRUITS; MULTIPLE-SCLEROSIS; BONE-DENSITY; D DEFICIENCY; RISK; SUSCEPTIBILITY; ADOLESCENTS; CALCIUM AB Low serum 25-hydroxyvitamin D [25(OH)D] concentrations are associated with hip fractures, but the dose-response relationship of serum 25(OH)D with risk of stress fractures in young women is unknown. This nested case-control study in a cohort of female Navy recruits was designed to determine whether those with low prediagnostic serum 25(OH)D concentrations had greater risk of stress fracture. Sera were drawn in 2002-2009 from 600 women who were diagnosed subsequently with stress fracture of the tibia or fibula and 600 matched controls who did not experience a stress fracture. The 25(OH)D concentration was measured using the DiaSorin radioimmunoassay method. Controls were individually matched to cases on race (white, black, or other), length of service (+/- 30 days), and day blood was drawn (+/- 2 days). There was approximately half the risk of stress fracture in the top compared with the bottom quintile of serum 25(OH)D concentration (odds ratio [OR] = 0.51, 95% CI 0.34-0.76, p <= 0.01). The range of serum 25(OH)D in the lowest quintile was 1.5 to 19.7 (mean 13.9) ng/mL, whereas in the highest it was 39.9 to 112 (mean 49.7) ng/mL. It is concluded that there was a monotonic inverse dose-response gradient between serum 25(OH)D and risk of stress fracture. There was double the risk of stress fractures of the tibia and fibula in women with serum 25(OH)D concentrations of less than 20 ng/mL compared to those with concentrations of 40 ng/mL or greater. A target for prevention of stress fractures would be a serum 25(OH)D concentration of 40 ng/mL or greater, achievable with 4000 IU/d of vitamin D(3) supplementation. (C) 2011 American Society for Bone and Mineral Research. C1 [Gorham, Edward D.; Garland, Cedric F.; Mohr, Sharif B.; Garland, Frank C.] Univ Calif San Diego, Dept Family & Prevent Med, Sch Med, La Jolla, CA 92093 USA. [Burgi, Alina A.; Gorham, Edward D.; Mohr, Sharif B.; Garland, Frank C.; Zeng, Kenneth; Thompson, Kerry] USN, Hlth Res Ctr, Dept Behav Sci & Epidemiol, San Diego, CA 92152 USA. [Lappe, Joan M.] Creighton Univ, Sch Med, Dept Med, Osteoporosis Res Ctr, Omaha, NE USA. RP Garland, CF (reprint author), Univ Calif San Diego, Dept Family & Prevent Med 0620, La Jolla, CA 92093 USA. EM cgarland@ucsd.edu FU US Army Medical Research and Materiel Command's Military Operational Medicine Research (Fort Detrick, MD) [63706N-60836] FX We express our deepest thanks and appreciation to Dr Angie Eick, special studies lead at the Armed Forces Health Surveillance Center, for her invaluable assistance, expert advice, and thoughtful consultation and review. Funding was provided by the US Army Medical Research and Materiel Command's Military Operational Medicine Research Program for Bone Health and Military Medical Readiness (Fort Detrick, MD) under Work Unit No. 63706N-60836. NR 35 TC 27 Z9 27 U1 1 U2 3 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0884-0431 J9 J BONE MINER RES JI J. Bone Miner. Res. PD OCT PY 2011 VL 26 IS 10 BP 2371 EP 2377 DI 10.1002/jbmr.451 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 824ZQ UT WOS:000295241100005 PM 21698667 ER PT J AU Es-Said, OS Parrish, CJ Bradberry, CA Hassoun, JY Parish, RA Nash, A Smythe, NC Tran, KN Ruperto, T Lee, EW Mitchell, D Vinquist, C AF Es-Said, O. S. Parrish, C. J. Bradberry, C. A. Hassoun, J. Y. Parish, R. A. Nash, A. Smythe, N. C. Tran, K. N. Ruperto, T. Lee, E. W. Mitchell, D. Vinquist, C. TI Effect of Stretch Orientation and Rolling Orientation on the Mechanical Properties of 2195 Al-Cu-Li Alloy SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE LA English DT Article DE 2195 Al-Li; anisotropy; rolling orientation; stretch orientation ID ALUMINUM-LITHIUM ALLOY; CRYSTALLOGRAPHIC TEXTURE; BEHAVIOR; ANISOTROPY; PLATE; FLOW AB Sheets of 2195 aluminum-lithium alloy were solution-treated at 507 A degrees C for 30 min. One set was stretched to 3-5% in the 0A degrees, 45A degrees, and 90A degrees angle with respect to the original rolling direction. Two other sets were rolled 6% reduction in thickness and 24% reduction in thickness in the 0A degrees, 45A degrees, and 90A degrees angle with respect to the original rolling direction. All specimens were aged at 143 A degrees C for 36 h. A second group of samples was rolled at 24 and 50% reduction in thickness after a solution treatment of 507 A degrees C for 1 h prior to aging at 190 A degrees C for 24 h. Tensile specimens were machined from each sheet at 0A degrees, 45A degrees, and 90A degrees angles to the original grain orientation. Tensile testing was used to determine the mechanical properties and anisotropic behavior of each condition. Rolling 6% reduction in thickness in the 45A degrees orientation yielded anisotropy of 7.6% in the yield strength. C1 [Es-Said, O. S.; Parrish, C. J.; Bradberry, C. A.; Hassoun, J. Y.; Parish, R. A.; Nash, A.; Smythe, N. C.; Tran, K. N.; Ruperto, T.; Mitchell, D.; Vinquist, C.] Loyola Marymount Univ, Dept Mech Engn, Los Angeles, CA 90045 USA. [Lee, E. W.] Naval Air Warfare Ctr, Patuxent River, MD 20670 USA. RP Es-Said, OS (reprint author), Loyola Marymount Univ, Dept Mech Engn, Los Angeles, CA 90045 USA. EM oessaid@lmu.edu FU National Science Foundation, NSF [EEC-9732046] FX This study was funded by the National Science Foundation, NSF Grant No. EEC-9732046, Research Experience for Undergraduates (REU) site. NR 31 TC 1 Z9 1 U1 1 U2 19 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9495 J9 J MATER ENG PERFORM JI J. Mater. Eng. Perform. PD OCT PY 2011 VL 20 IS 7 BP 1171 EP 1179 DI 10.1007/s11665-010-9746-6 PG 9 WC Materials Science, Multidisciplinary SC Materials Science GA 821GX UT WOS:000294964100010 ER PT J AU Miranda, W Takiguchi, G Shimabukuro, T McLennan, L Agajanian, C Quintero, L Mismar, D Abdulla, J Andrews, C Hahn, M Fodran, E Lee, EW Garmestani, H Conner, RD Brick, D Ogren, J Es-Said, OS AF Miranda, W. Takiguchi, G. Shimabukuro, T. McLennan, L. Agajanian, C. Quintero, L. Mismar, D. Abdulla, J. Andrews, C. Hahn, M. Fodran, E. Lee, E. W. Garmestani, H. Conner, R. D. Brick, D. Ogren, J. Es-Said, O. S. TI Innovative Manufacturing Process for Defect Free, Affordable, High Pressure, Thin Walled, Hydraulic Tubing SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE LA English DT Article DE cold rolling and annealing; optimization of mechanical properties; Ti-6Al-4V AB Various thermo-mechanical processes were performed on a standard and a low oxygen content Ti-6Al-4V alloy. Testing was performed to determine whether it was possible to achieve a combination of tensile properties comparable to those of Ti-3Al-2.5V by means of cold working and annealing Ti-6Al-4V from a thickness of 0.671 cm (0.264 in.) to that between 0.081 and 0.094 cm (0.032-0.037 in.), which had never been carried out before. The resulting mechanical properties of this study were compared to the mechanical properties of Ti-3Al-2.5V to determine whether Ti-6Al-4V could be used as a suitable replacement for hydraulic tubing applications. The optimum results were achieved with 10-15% cold work and annealing at 750 A degrees C (1382 A degrees F) for 2 h between cold work reductions in thickness. It was concluded that Ti-6Al-4V was a suitable replacement for Ti-3Al-2.5V for hydraulic tubing with an increase in ultimate and yield strengths, but with a slight sacrifice of 5-10% elongation. C1 [Miranda, W.; Takiguchi, G.; Shimabukuro, T.; McLennan, L.; Agajanian, C.; Quintero, L.; Mismar, D.; Abdulla, J.; Andrews, C.; Ogren, J.; Es-Said, O. S.] Loyola Marymount Univ, Dept Mech Engn, Los Angeles, CA 90045 USA. [Hahn, M.; Fodran, E.] Air Combat Syst, Northrop Grumman, El Segundo, CA 90245 USA. [Lee, E. W.] Naval Air Warfare Ctr, Naval Air Syst Command, Patuxent River, MD 20670 USA. [Garmestani, H.] Georgia Inst Technol, Atlanta, GA 30332 USA. [Conner, R. D.] Calif State Univ Northridge, Northridge, CA 91330 USA. [Brick, D.] Fasteel Corp, Anaheim, CA 92805 USA. RP Miranda, W (reprint author), Loyola Marymount Univ, Dept Mech Engn, Los Angeles, CA 90045 USA. EM oessaid@lmu.edu NR 19 TC 1 Z9 1 U1 0 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9495 J9 J MATER ENG PERFORM JI J. Mater. Eng. Perform. PD OCT PY 2011 VL 20 IS 7 BP 1206 EP 1218 DI 10.1007/s11665-010-9736-8 PG 13 WC Materials Science, Multidisciplinary SC Materials Science GA 821GX UT WOS:000294964100014 ER PT J AU Keleshian, N Kyser, R Rodriguez, J Cueva, C Vega, V Lee, EW Ogren, J Es-Said, OS AF Keleshian, N. Kyser, R. Rodriguez, J. Cueva, C. Vega, V. Lee, E. W. Ogren, J. Es-Said, O. S. TI On the Distortion and Warpage of 7249 Aluminum Alloy After Quenching and Machining SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE LA English DT Article DE 7249 aluminum alloy; quenching media; T6 temper; warpage AB The objective of this study is to determine the effect of solution treatment temperature, quenching media, and various machining sequences on the warpage behavior of aluminum 7249 alloy aged to T6 and T7' tempers. Large extrusions of 7249 aluminum alloy with fins were cut into 108 "T" sections. The samples were solution-treated, aged, and machined. Three solution temperatures (445, 474, and 505 A degrees C), two quenching media (water and 20% polyalkylene glycol), two aging treatments (T6 and T7'), and three machine sequences were used. The flatness of the samples was measured on the surfaces orthogonal to the z-axis. Three points were on top of both shoulders (six total), six were at the bottom of the sample, and six were on the top of the fin, in the cases where the fin was not milled off. They were then averaged together by surface to represent the overall warpage of each sample. C1 [Keleshian, N.; Kyser, R.; Rodriguez, J.; Cueva, C.; Ogren, J.; Es-Said, O. S.] Loyola Marymount Univ, Dept Mech Engn, Los Angeles, CA 90045 USA. [Vega, V.] Northrop Grumman Corp, El Segundo, CA 90425 USA. [Lee, E. W.] Naval Air Warfare Ctr, Naval Air Syst Command, Patuxent River, MD 20670 USA. RP Keleshian, N (reprint author), Loyola Marymount Univ, Dept Mech Engn, 1 LMU Blvd, Los Angeles, CA 90045 USA. EM oessaid@lmu.edu NR 7 TC 1 Z9 3 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9495 J9 J MATER ENG PERFORM JI J. Mater. Eng. Perform. PD OCT PY 2011 VL 20 IS 7 BP 1230 EP 1234 DI 10.1007/s11665-010-9756-4 PG 5 WC Materials Science, Multidisciplinary SC Materials Science GA 821GX UT WOS:000294964100016 ER PT J AU Gross, ML Beckstead, MW AF Gross, Matthew L. Beckstead, Merrill W. TI Steady-State Combustion Mechanisms of Ammonium Perchlorate Composite Propellants SO JOURNAL OF PROPULSION AND POWER LA English DT Article ID VORTICITY-VELOCITY FORMULATION; FLAMES; FLOWS AB The flame structures emanating from a mixture of ammonium perchlorate (AP) and hydroxy-terminated-polybutadiene (HTPB) have been calculated over a range of pressures and AP particle sizes using high-fidelity simulations. The calculated AP composite propellant flame structure consists of three premixed flames (AP monopropellant flame, homogenized-binder flame, and primary flame) and a diffusion flame. The variations in this flame structure, based on pressure and particle size, account for AP's unique combustion properties. As pressure is increased, the three premixed flames draw closer to the surface, increasing the propellant burning rate. However, the diffusion flame is forced farther into the gas phase, decreasing the propellant burning rate. This dichotomy creates large variations in how AP composite propellants burn at different pressures. Three regions of combustion have been calculated for AP composite propellants: the AP monopropellant limit, the diffusion flame region, and the premixed limit. The premixed limit represents the maximum burning rate, and the AP monopropellant limit represents the minimum burning rate. AP particle size and pressure dictate the region of combustion, as these parameters greatly affect the flame structure. A thorough explanation of AP's pressure and particle-size effects with regard to a propellant's burning rate is presented. Propellant burning rates and premixed cutoff diameters are predicted for an AP/HTPB system. The importance of correctly representing the homogenized binder in AP/HTPB propellant combustion simulations is also discussed. C1 [Gross, Matthew L.] USN, Air Warfare Ctr, Weap Div, China Lake, CA 93555 USA. [Beckstead, Merrill W.] Brigham Young Univ, Dept Chem Engn, Provo, UT 84602 USA. FU Naval Air Systems Command (NAVAIR) In-House Laboratory Independent Research (ILIR) FX This work was sponsored by the Naval Air Systems Command (NAVAIR) In-House Laboratory Independent Research (ILIR) program, managed at the Office of Naval Research by the N-STAR program (Naval Research-Science and Technology for America's Readiness). NR 24 TC 6 Z9 9 U1 3 U2 10 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0748-4658 J9 J PROPUL POWER JI J. Propul. Power PD SEP-OCT PY 2011 VL 27 IS 5 BP 1064 EP 1078 DI 10.2514/1.B34053 PG 15 WC Engineering, Aerospace SC Engineering GA 831CG UT WOS:000295705700016 ER PT J AU Stamatis, D Dreizin, EL Higa, K AF Stamatis, Demitrios Dreizin, Edward L. Higa, Kelvin TI Thermal Initiation of Al-MoO3 Nanocomposite Materials Prepared by Different Methods SO JOURNAL OF PROPULSION AND POWER LA English DT Article ID ENERGETIC MATERIALS; ALUMINUM; KINETICS; POWDERS; NANO; NANOPARTICLES; OXIDATION; IGNITION; AL AB Two types of nanocomposite reactive materials with the same bulk compositions 8Al center dot MoO3 were prepared and compared with each other. One of the materials was manufactured by arrested reactive milling and the other so-called metastable interstitial composite was manufactured by mixing of nanoscaled individual powders. The materials were characterized using differential scanning calorimetry, thermogravimetric, as well as ignition, experiments using an electrically heated filament and laser as heat sources. The experiments were interpreted using simplified models describing heat transfer in the heated material samples in different experimental configurations. Clear differences in the low-temperature redox reactions, well detectable by differential scanning calorimetry, were established between metastable interstitial composite and arrested-reactive-milling-prepared materials. However, the materials did not differ significantly from each other in the ignition experiments. In the heated filament ignition tests, their ignition temperatures were nearly identical to each other and were in the range of 750-800 K. These ignition temperatures coincided with the temperatures at which main exothermic processes were detected in differential scanning calorimetry experiments. In laser ignition experiments performed with consolidated pellets of both materials, metastable interstitial composite pellets produced consistently stronger pressure pulses. The ignition delays were similar for the pellets of both materials prepared with the same porosity. Analysis of the heat transfer in the pellets heated by the laser suggested that the laser-exposed pellet surfaces were heated to approximately the same temperature before ignition for both materials. This temperature was estimated to be close to 500 K, neglecting the exothermic reactions preceding ignition and possible fragmentation of the heated pellets. Taking into account both phenomena is expected to result in a higher surface temperature, which would better represent the experimental situation. It is proposed that the ignition of both metastable interstitial composite and arrested-reactive-milling-prepared materials at the same temperature can be explained by a thermodynamically driven transformation of a protective amorphous alumina into a crystalline polymorph. C1 [Stamatis, Demitrios; Dreizin, Edward L.] New Jersey Inst Technol, Newark, NJ 07102 USA. [Higa, Kelvin] USN, Air Warfare Ctr, Weap Div, China Lake, CA 93555 USA. RP Stamatis, D (reprint author), Dept Chem Biol & Pharmaceut Engn, University Hts, NJ USA. RI Dreizin, Edward/O-6416-2014; OI Dreizin, Edward/0000-0003-0859-0984 FU Defense Threat Reduction Agency FX This work was supported by the Defense Threat Reduction Agency. NR 22 TC 13 Z9 13 U1 0 U2 13 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0748-4658 J9 J PROPUL POWER JI J. Propul. Power PD SEP-OCT PY 2011 VL 27 IS 5 BP 1079 EP 1087 DI 10.2514/1.B34179 PG 9 WC Engineering, Aerospace SC Engineering GA 831CG UT WOS:000295705700017 ER PT J AU Hayat, AM Tribble, DR Sanders, JW Faix, DJ Shiau, D Armstrong, AW Riddle, MS AF Hayat, Aatif M. Tribble, David R. Sanders, John W. Faix, Dennis J. Shiau, Danny Armstrong, Adam W. Riddle, Mark S. TI Knowledge, Attitudes, and Practice of Travelers' Diarrhea Management among Frontline Providers SO JOURNAL OF TRAVEL MEDICINE LA English DT Article ID OPERATIONS IRAQI FREEDOM; ANTIMICROBIAL THERAPY; ENDURING FREEDOM; EVIDENCE BASE; US MILITARY; EPIDEMIOLOGY; PREVENTION; LOPERAMIDE; IMPACT; POPULATIONS AB Background. Many studies have found acute gastrointestinal infections to be among the most likely reason for clinic visits among forward deployed soldiers and are considered a significant contributor to morbidity in this population. This occurs despite the controlled food and water distribution systems under which military populations operate. Furthermore, recent studies have indicated that providers often fail to appropriately identify and treat the typical causes of these infections. To adequately address this issue, an assessment of gaps in knowledge, practice, and management of acute diarrhea in deployed troops was conducted. Methods. A multiple-choice survey was developed by clinical researchers with expertise in travelers' diarrhea (TD) and provided to a convenience sample of clinical providers with a broad range of training and operational experience. The survey evaluated provider's knowledge of TD along with their ability to identify etiologies of various syndromic categories of acute gastrointestinal infections. Providers were also queried on selection of treatment approaches to a variety of clinical-based scenarios. Results. A total of 117 respondents completed the survey. Most were aware of the standard definition of TD (77%); however, their knowledge about the epidemiology was lower, with less than 24% correctly answering questions on etiology of diarrhea, and 31% believing that a viral pathogen was the primary cause of watery diarrhea during deployment. Evaluation of scenario-based responses showed that 64% of providers chose not to use antibiotics to treat moderate TD. Furthermore, 19% of providers felt that severe inflammatory diarrhea was best treated with hydration only while 25% felt hydration was the therapy of choice for dysentery. Across all provider types, three practitioner characteristics appeared to be related to better scores on responses to the nine management scenarios: having a Doctor of Medicine or Doctor of Osteopathy degree, greater knowledge of TD epidemiology, and favorable attitudes toward antimotility or antibiotic therapy. Conclusion. Results from this survey support the need for improving knowledge and management of TD among deploying providers. The information from this study should be considered to support the establishment and dissemination of military diarrhea-management guidelines to assist in improving the health of military personnel. C1 [Hayat, Aatif M.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Tribble, David R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Sanders, John W.] Naval Med Res Ctr Detachment, Lima, Peru. [Faix, Dennis J.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Shiau, Danny] USN, Bur Med & Surg, Washington, DC USA. [Armstrong, Adam W.] US Naval Med Res Unit 3, Cairo, Egypt. [Riddle, Mark S.] USN, Med Res Ctr, Enter Dis Dept, Silver Spring, MD 20910 USA. RP Riddle, MS (reprint author), USN, Med Res Ctr, Enter Dis Dept, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM mark.riddle@med.navy.mil RI Riddle, Mark/A-8029-2011 NR 22 TC 4 Z9 4 U1 0 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1195-1982 J9 J TRAVEL MED JI J. Travel Med. PD SEP-OCT PY 2011 VL 18 IS 5 BP 310 EP 317 DI 10.1111/j.1708-8305.2011.00538.x PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 818DI UT WOS:000294730700004 PM 21896094 ER PT J AU Scarlett, HP Nisbett, RA Stoler, J Bain, BC Bhatta, MP Castle, T Harbertson, J Brodine, SK Vermund, SH AF Scarlett, Henroy P. Nisbett, Richard A. Stoler, Justin Bain, Brendan C. Bhatta, Madhav P. Castle, Trevor Harbertson, Judith Brodine, Stephanie K. Vermund, Sten H. TI South-to-North, Cross-Disciplinary Training in Global Health Practice: Ten Years of Lessons Learned from an Infectious Disease Field Course in Jamaica SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID EXPERIENCES; PROGRAMS AB Global commerce, travel, and emerging and resurging infectious diseases have increased awareness of global health threats and opportunities for collaborative and service learning. We review course materials, knowledge archives, data management archives, and student evaluations for the first 10 years of an intensive summer field course in infectious disease epidemiology and surveillance offered in Jamaica. We have trained 300 students from 28 countries through collaboration between the University of the West Indies and U.S. partner universities. Participants were primarily graduate students in public health, but also included health professionals with terminal degrees, and public health nurses and inspectors. Strong institutional synergies, committed faculty, an emphasis on scientific and cultural competencies, and use of team-based field research projects culminate in a unique training environment that provides participants with career-developing experiences. We share lessons learned over the past decade, and conclude that South-to-North leadership is critical in shaping transdisciplinary, cross-cultural, global health practice. C1 [Nisbett, Richard A.] Univ S Florida, Coll Publ Hlth, Dept Global Hlth, Tampa, FL USA. [Stoler, Justin] San Diego State Univ, Dept Geog, San Diego, CA 92182 USA. [Brodine, Stephanie K.] San Diego State Univ, Grad Sch Publ Hlth, Div Epidemiol & Biostat, San Diego, CA 92182 USA. Kent State Univ, Sch Publ Hlth, Dept Biostat Environm Hlth Sci & Epidemiol, Kent, OH 44242 USA. [Harbertson, Judith] Naval Hlth Res Ctr, US Mil HIV Res Program, San Diego, CA USA. [Vermund, Sten H.] Vanderbilt Univ, Sch Med, Inst Global Hlth, Nashville, TN 37212 USA. Univ W Indies, Dept Community Hlth & Psychiat, Kingston 7, Jamaica. [Scarlett, Henroy P.] Univ W Indies, Dept Community Hlth & Psychiat, Mona Kingston 7, Jamaica. [Bain, Brendan C.] Univ W Indies Mona, Univ W Indies, HIV AIDS Response Programme UWI HARP,Off Vice Cha, Caribbean HIVAIDS Reg Training Network,Reg Coordi, Kingston 7, Jamaica. [Castle, Trevor] Minist Hlth, Kingston 6, Jamaica. RP Scarlett, HP (reprint author), Univ W Indies, Dept Community Hlth & Psychiat, Mona Kingston 7, Jamaica. EM henpscar@gmail.com; rnisbett@health.usf.edu; stoler@rohan.sdsu.edu; brendan.bain@uwimona.edu.jm; mbhatta@kent.edu; trevicastle@yahoo.com; judith.harbertson@med.navy.mil; sbrodine@mail.sdsu.edu; sten.vermund@vanderbilt.edu RI yan, liu/A-1822-2015; OI yan, liu/0000-0001-8517-1084; Vermund, Sten/0000-0001-7289-8698 NR 22 TC 3 Z9 3 U1 1 U2 8 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD SEP PY 2011 VL 85 IS 3 BP 397 EP 404 DI 10.4269/ajtmh.2011.10-0524 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 816EL UT WOS:000294581400003 PM 21896794 ER PT J AU MacGregor, A Dougherty, A Tang, J Galarneau, M AF MacGregor, Andrew Dougherty, Amber Tang, Janet Galarneau, Michael TI Post-concussive Symptom Reporting Among US Combat Veterans with Mild Traumatic Brain Injury from Operation Iraqi Freedom SO JOURNAL OF HEAD TRAUMA REHABILITATION LA English DT Meeting Abstract C1 [MacGregor, Andrew; Dougherty, Amber; Tang, Janet; Galarneau, Michael] USN, Hlth Res Ctr, San Diego, CA 92152 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0885-9701 J9 J HEAD TRAUMA REHAB JI J. Head Trauma Rehabil. PD SEP-OCT PY 2011 VL 26 IS 5 MA 0032 BP 413 EP 414 PG 2 WC Clinical Neurology; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA 814VO UT WOS:000294485500038 ER PT J AU Duplessis, CA Tilley, D Bavaro, M Hale, B Holland, SM AF Duplessis, Christopher A. Tilley, Drake Bavaro, Mary Hale, Braden Holland, Steven M. TI Two cases illustrating successful adjunctive interferon-gamma immunotherapy in refractory disseminated coccidioidomycosis SO JOURNAL OF INFECTION LA English DT Article DE Interferon; Coccidioidomycosis; Immunotherapy; IFN-gamma; IL-12 ID MYCOBACTERIAL INFECTION; RECEPTOR AB Protective immunity and host resistance to coccidioidomycosis require a robust cell-mediated immunity with adequate production of Th1 cytokines including interleukin-12, and IFN-gamma and appropriate regulation and coordinated functionality of Th1/Th2 responses and IL-12/IFN-gamma cytokine axes. IFN-gamma augments the anti-fungal activity of effector immune cells against a variety of fungi. Numerous animal models have demonstrated the potential efficacy of adjunctive IFN-gamma in treatment of invasive mycoses. Yet, despite these promising data, a paucity of literature documents efficacious adjunctive IFN-gamma administration in refractory coccidioidomycosis. We present two cases of refractory disease occurring at our institution who responded to adjunctive IFN-gamma. Published by Elsevier Ltd on behalf of The British Infection Association. C1 [Duplessis, Christopher A.; Tilley, Drake; Bavaro, Mary; Hale, Braden] Infect Dis Naval Hosp, Naval Med Ctr San Diego, San Diego, CA 92134 USA. [Holland, Steven M.] NIAID, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA. RP Duplessis, CA (reprint author), Infect Dis Naval Hosp, Naval Med Ctr San Diego, 34800 Bob Wilson Dr,Ste 5, San Diego, CA 92134 USA. EM christopher.duplessis@med.navy.mil FU Intramural NIH HHS [Z01 AI000647-16] NR 11 TC 8 Z9 8 U1 0 U2 0 PU W B SAUNDERS CO LTD PI LONDON PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND SN 0163-4453 J9 J INFECTION JI J. Infect. PD SEP PY 2011 VL 63 IS 3 BP 223 EP 228 DI 10.1016/j.jinf.2011.07.006 PG 6 WC Infectious Diseases SC Infectious Diseases GA 814JX UT WOS:000294448000006 PM 21791226 ER PT J AU Mohr, SB Gorham, ED Alcaraz, JE Kane, CJ Macera, CA Parsons, JK Wingard, DL Garland, CF AF Mohr, Sharif B. Gorham, Edward D. Alcaraz, John E. Kane, Christopher J. Macera, Caroline A. Parsons, J. Kellogg Wingard, Deborah L. Garland, Cedric F. TI Serum 25-Hydroxyvitamin D and Prevention of Breast Cancer: Pooled Analysis SO ANTICANCER RESEARCH LA English DT Article DE Vitamin D; 25-hydroxyvitamin D; breast neoplasms; case control studies; epidemiology; meta-analysis; prevention ID VITAMIN-D SUPPLEMENTATION; DOSE-RESPONSE; FOREST PLOTS; RISK; CALCIUM; MORTALITY; CELLS; POPULATION; SAFETY; COLON AB Background: Low serum levels of 25-hydroxyvitamin D [25(OH)D] have been associated with a high risk of breast cancer. Since publication of the most current meta-analysis of 25(OH)D and breast cancer risk, two new nested case-control studies have emerged. Materials and Methods: A PubMed search for all case-control studies on risk of breast cancer by 25(OH)D concentration identified I 1 eligible studies. Data from all 11 studies were combined in order to calculate the pooled odds ratio of the highest vs. lowest quantile of 25(OH)D across all studies. Results: The overall Peto odds ratio summarizing the estimated risk in the highest compared to the lowest quantile across all 11 studies was 0.61 (95% confidence interval 0.47, 0.80). Conclusion: This study supports the hypothesis that higher serum 25(OH)D levels reduce the risk of breast cancer. According to the review of observational studies, a serum 25(OH)D level of 47 ng/ml was associated with a 50% lower risk of breast cancer. C1 [Mohr, Sharif B.; Gorham, Edward D.; Wingard, Deborah L.; Garland, Cedric F.] Univ Calif San Diego, Dept Family & Prevent Med, Div Epidemiol, Sch Med, La Jolla, CA 92093 USA. [Kane, Christopher J.; Parsons, J. Kellogg] Univ Calif San Diego, Dept Surg, Sch Med, La Jolla, CA 92093 USA. [Gorham, Edward D.; Macera, Caroline A.; Garland, Cedric F.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Alcaraz, John E.; Macera, Caroline A.] San Diego State Univ, Grad Sch Publ Hlth, Dept Epidemiol & Biostat, San Diego, CA 92182 USA. RP Mohr, SB (reprint author), Univ Calif San Diego, Dept Family & Prevent Med, Div Epidemiol, Sch Med, 9500 Gilman Dr,0620, La Jolla, CA 92093 USA. EM sbmohr75@gmail.com FU Department of the Navy, Bureau of Medicine and Surgery [60126] FX This research was supported by a Congressional allocation to the Penn State Cancer Institute of the Milton S. Hershey Medical Center, Hershey, PA, through the Department of the Navy, Bureau of Medicine and Surgery, under Work Unit No. 60126. The views expressed in this report are those of the Authors and do not represent an official position of the Department of the Navy, Department of Defense, or the U.S. Government. NR 66 TC 33 Z9 33 U1 0 U2 2 PU INT INST ANTICANCER RESEARCH PI ATHENS PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22, ATHENS 19014, GREECE SN 0250-7005 EI 1791-7530 J9 ANTICANCER RES JI Anticancer Res. PD SEP PY 2011 VL 31 IS 9 BP 2939 EP 2948 PG 10 WC Oncology SC Oncology GA 800KG UT WOS:000293357700035 PM 21868542 ER PT J AU Landrum, ML Roediger, MP Fieberg, AM Weintrob, AC Okulicz, JF Crum-Cianflone, NF Ganesan, A Lalani, T Macalino, GE Chun, HM AF Landrum, Michael L. Roediger, Mollie P. Fieberg, Ann M. Weintrob, Amy C. Okulicz, Jason F. Crum-Cianflone, Nancy F. Ganesan, Anuradha Lalani, Tahaniyat Macalino, Grace E. Chun, Helen M. TI Development of Chronic Hepatitis B Virus Infection in Hepatitis B Surface Antigen Negative HIV/HBV Co-Infected Adults: A Rare Opportunistic Illness SO JOURNAL OF MEDICAL VIROLOGY LA English DT Article DE hepatitis B virus; chronic hepatitis B virus; human immunodeficiency virus; CD4 cell count; opportunistic illness ID ACTIVE ANTIRETROVIRAL THERAPY; HUMAN-IMMUNODEFICIENCY-VIRUS; HIV; SEROCONVERSION; INDIVIDUALS; EVOLUTION; COHORT; HBV AB Changes in serologic status in human immunodeficiency virus (HIV)/hepatitis B virus (HBV) co-infected individuals with either isolated anti-HBc or resolved HBV infection have been reported, but the frequency of clinically meaningful long-term serologic changes is not well-defined. This study therefore, examined longitudinal serologic status for hepatitis B surface antigen (HBsAg)-negative HIV/HBV co-infected participants in a large cohort. Among 5,222 cohort participants, 347 (7%) were initially isolated anti-HBc positive, and 1,073 (21%) had resolved HBV infection (concurrently reactive for anti-HBc and anti-HBs). Thirty-three (10%) of the 347 participants with isolated anti-HBc were later positive for HBsAg at least once, compared with 3 (0.3%) of those with resolved HBV (P < 0.001). A total of 14 participants became persistently positive for HBsAg and were thus classified as having late-onset chronic HBV infection at a median of 3.7 years after initial HBV diagnosis. For those initially with HBsAg-negative HIV/HBV co-infection, the rate of late-onset chronic HBV infection was 1.39/1,000 person-years. Those with late-onset chronic HBV infection experienced significant decreases in CD4 cell counts (P = 0.002) with a mean of 132 cells/mu l at the time of late-onset chronic HBV infection, but no factor distinguished those who were positive for HBsAg only once from those that developed late-onset chronic HBV infection. Over a median of 2.9 years following late-onset chronic HBV infection, 3 of 14 subsequently lost HBsAg. The occurrence of late-onset chronic HBV infection in HBsAg negative HIV/HBV co-infected adults appears to be one important, albeit rare, clinical event seen almost exclusively in those with isolated anti-HBc and low CD4 cell count. J. Med. Virol. 83: 1537-1543, 2011. (C) 2011 Wiley-Liss, Inc. C1 [Landrum, Michael L.] San Antonio Mil Med Ctr, Infect Dis Serv, MCHE MDI, Ft Sam Houston, TX 78234 USA. [Landrum, Michael L.; Roediger, Mollie P.; Fieberg, Ann M.; Weintrob, Amy C.; Crum-Cianflone, Nancy F.; Ganesan, Anuradha; Lalani, Tahaniyat; Macalino, Grace E.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Roediger, Mollie P.; Fieberg, Ann M.] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Weintrob, Amy C.] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. [Crum-Cianflone, Nancy F.] USN, Med Ctr, Infect Dis Clin, San Diego, CA 92152 USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Div Infect Dis, Bethesda, MD USA. [Lalani, Tahaniyat] USN, Med Ctr, Div Infect Dis, Portsmouth, VA USA. [Chun, Helen M.] USN, Hlth Res Ctr, Dept Def HIV AIDS Prevent Program, San Diego, CA 92152 USA. RP Landrum, ML (reprint author), San Antonio Mil Med Ctr, Infect Dis Serv, MCHE MDI, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM mlandrum@idcrp.org FU Infectious Disease Clinical Research Program (IDCRP) [IDCRP-000-27]; Uniformed Services University of the Health Sciences (Department of Defense (DoD)); National Institute of Allergy and Infectious Diseases; National Institutes of Health (NIH) [Y1-AI-5072] FX Grant sponsor: Infectious Disease Clinical Research Program (IDCRP, www.idcrp.org); Grant number: IDCRP-000-27; Grant sponsor: Uniformed Services University of the Health Sciences (Department of Defense (DoD) Program); Grant sponsor: National Institute of Allergy and Infectious Diseases (in whole or in part); Grant sponsor: National Institutes of Health (NIH; Inter-Agency Agreement); Grant number: Y1-AI-5072. NR 16 TC 1 Z9 1 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0146-6615 J9 J MED VIROL JI J. Med. Virol. PD SEP PY 2011 VL 83 IS 9 BP 1537 EP 1543 DI 10.1002/jmv.22155 PG 7 WC Virology SC Virology GA 790OW UT WOS:000292600100007 PM 21739443 ER PT J AU Guenthner, AJ Lamison, KR Yandek, GR Masurat, KC Reams, JT Cambrea, LR Mabry, JM AF Guenthner, Andrew J. Lamison, Kevin R. Yandek, Gregory R. Masurat, Kenneth C. Reams, Josiah T. Cambrea, Lee R. Mabry, Joseph M. TI Role of concurrent chemical and physical processes in determining the maximum use temperatures of thermosetting polymers for aerospace applications SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 242nd National Meeting of the American-Chemical-Society (ACS) CY AUG 28-SEP 01, 2011 CL Denver, CO SP Amer Chem Soc (ACS) C1 [Reams, Josiah T.] USAF, Prop Directorate, Natl Res Council, Res Lab, Edwards Afb, CA 93524 USA. [Lamison, Kevin R.; Masurat, Kenneth C.] ERC Inc, Edwards Afb, CA 93524 USA. [Cambrea, Lee R.] USN, Air Warfare Ctr, China Lake, CA 93555 USA. EM andrew.guenthner@edwards.af.mil NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 28 PY 2011 VL 242 MA 262-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 880BE UT WOS:000299378306848 ER PT J AU Halterman, K Valls, OT Alidoust, M AF Halterman, Klaus Valls, Oriol T. Alidoust, Mohammad TI Characteristic energies, transition temperatures, and switching effects in clean S vertical bar N vertical bar S graphene nanostructures SO PHYSICAL REVIEW B LA English DT Article ID SUPERCONDUCTORS; SUPERCURRENT; TRANSPORT AB We study proximity effects in clean nanoscale superconductor-normal-metal-superconductor (S|N|S) graphene heterostructures using a self-consistent numerical solution to the continuum Dirac Bogoliubov-de Gennes (DBdG) equations. We obtain results for the pair amplitude and the local density of states (DOS) as a function of doping and of the geometrical parameters determining the width of the structures. The superconducting correlations are found to penetrate the normal graphene layers even when there is extreme mismatch in the normal and superconducting doping levels, where specular Andreev reflection dominates. The local DOS exhibits peculiar features, which we discuss, arising from the Dirac cone dispersion relation and from the interplay between the superconducting and Thouless energy scales. The corresponding characteristic energies emerge in the form of resonant peaks in the local DOS, which depend strongly on the doping level, as does the energy gap, which declines sharply as the relative difference in doping between the S and N regions is reduced. We also linearize the DBdG equations and develop an essentially analytical method that determines the critical temperature T-c of a S|N|S nanostructure self-consistently. We find that for S regions that occupy a fraction of the coherence length, T-c can undergo substantial variations as a function of the relative doping. At finite temperatures and by manipulating the doping levels, the self-consistent pair amplitudes reveal dramatic transitions between a superconducting and resistive normal state of the structure. Such behavior suggests the possibility of using the proposed system as a carbon-based superconducting switch, turning superconductivity on or off by tuning the relative doping levels. C1 [Halterman, Klaus] USN, Michelson Lab, Div Phys, Air Warfare Ctr, China Lake, CA 93555 USA. [Valls, Oriol T.] Univ Minnesota, Sch Phys & Astron, Minneapolis, MN 55455 USA. [Alidoust, Mohammad] Norwegian Univ Sci & Technol, Dept Phys, N-7491 Trondheim, Norway. [Valls, Oriol T.] Univ Minnesota, Minnesota Supercomp Inst, Minneapolis, MN 55455 USA. [Alidoust, Mohammad] Univ Isfahan, Dept Phys, Fac Sci, Esfahan 8174673441, Iran. RP Halterman, K (reprint author), USN, Michelson Lab, Div Phys, Air Warfare Ctr, China Lake, CA 93555 USA. EM klaus.halterman@navy.mil; otvalls@umn.edu; mohammad.alidoust@ntnu.no RI Halterman, Klaus/G-3826-2012; OI Halterman, Klaus/0000-0002-6355-3134; Alidoust, Mohammad/0000-0002-1554-687X FU ONR; DOD (HPCMP); Minnesota Supercomputer Institute FX This work is supported in part by ONR and by grants of HPC resources from DOD (HPCMP) and from the Minnesota Supercomputer Institute. M. A. wishes to thank J. Linder for conversations. NR 47 TC 5 Z9 5 U1 0 U2 10 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9950 EI 2469-9969 J9 PHYS REV B JI Phys. Rev. B PD AUG 19 PY 2011 VL 84 IS 6 AR 064509 DI 10.1103/PhysRevB.84.064509 PG 13 WC Physics, Condensed Matter SC Physics GA 809KV UT WOS:000294055000011 ER PT J AU Halterman, K Feng, SM Nguyen, VC AF Halterman, Klaus Feng, Simin Viet Cuong Nguyen TI Controlled leaky wave radiation from anisotropic epsilon near zero metamaterials SO PHYSICAL REVIEW B LA English DT Article ID ELECTROMAGNETIC ENERGY; PROPAGATION; INDEX; REFRACTION; ANGLE; LAYER AB We investigate the emission of electromagnetic waves from biaxial subwavelength metamaterials. For anisotropic structures that exhibit a vanishing dielectric response along the longitudinal axis and possess a tunable transverse dielectric response, we find remarkable variation in the launch angles of energy associated with the emission of leaky wave radiation. We write closed-form expressions for the energy transport velocity and corresponding radiation angle phi, defining the cone of radiation emission, as functions both of frequency and of material and geometrical parameters. Full wave simulations exemplify the broad range of directivity that can be achieved in these structures. C1 [Halterman, Klaus; Feng, Simin] USN, Air Warfare Ctr, Michelson Lab, Div Phys, China Lake, CA 93555 USA. [Viet Cuong Nguyen] Nanyang Technol Univ, Sch Elect & Elect Engn, Photon Res Ctr, Singapore 639798, Singapore. RP Halterman, K (reprint author), USN, Air Warfare Ctr, Michelson Lab, Div Phys, China Lake, CA 93555 USA. RI Halterman, Klaus/G-3826-2012; OI Nguyen, Viet Cuong/0000-0003-1145-5652; Halterman, Klaus/0000-0002-6355-3134 FU ONR; HPC resources as part of the DOD HPCMP FX K.H. is supported in part by ONR and a grant of HPC resources as part of the DOD HPCMP. NR 35 TC 14 Z9 14 U1 1 U2 16 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 EI 1550-235X J9 PHYS REV B JI Phys. Rev. B PD AUG 18 PY 2011 VL 84 IS 7 AR 075162 DI 10.1103/PhysRevB.84.075162 PG 7 WC Physics, Condensed Matter SC Physics GA 809BV UT WOS:000294026600001 ER PT J AU Krantz, EM Hullsiek, KH Okulicz, JF Weintrob, AC Agan, BK Crum-Cianflone, NF Ganesan, A Ferguson, TM Hale, BR AF Krantz, Elizabeth M. Hullsiek, Katherine Huppler Okulicz, Jason F. Weintrob, Amy C. Agan, Brian K. Crum-Cianflone, Nancy F. Ganesan, Anuradha Ferguson, Tomas M. Hale, Braden R. CA Infect Dis Clin Res Program HIV TI Elevated CD8 Counts During HAART Are Associated With HIV Virologic Treatment Failure SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE human immunodeficiency virus; CD8 count; antiretroviral therapy; HIV viral load suppression; HIV virologic failure ID ACTIVE ANTIRETROVIRAL THERAPY; IMMUNE ACTIVATION MARKERS; T-CELL-ACTIVATION; HIV-1-INFECTED PATIENTS; CD38 EXPRESSION; PROTEASE INHIBITOR; PROGNOSTIC VALUE; INFECTED INDIVIDUALS; DISEASE PROGRESSION; VIRAL REPLICATION AB Objective: To evaluate whether elevated CD8 counts are associated with increased risk of virologic treatment failure in HIV-infected individuals. Design: Retrospective cohort study. Methods: US Military HIV Natural History Study participants who initiated highly active antiretroviral therapy (HAART) in 1996-2008 had 6- and 12-month post-HAART HIV RNA <400 copies per milliliter, >= 2 subsequent HIV viral loads and a baseline CD8 count were eligible (n = 817). Baseline was 12 months after the start of HAART, virologic failure (VF) was defined as confirmed HIV RNA >= 400 copies per milliliter, and CD8 counts >= 1200 cells per cubic millimeter were considered elevated. Cox models were used to examine the effect of baseline and time-updated CD8 counts on VF. Results: There were 216 failures for a rate of 5.6 per 100 person-years [95% confidence interval (CI): 4.9 to 6.4]. Among those initiating HAART in 2000-2008, the participants with elevated baseline CD8 counts had significantly greater risk of VF compared with those with baseline CD8 counts <= 600 cells per cubic millimeter [hazard ratio (HR) = 2.68, 95% CI: 1.13 to 6.35]. The participants with elevated CD8 counts at >20% of previous 6-month follow-up visits had a greater risk of failure at the current visit than those who did not (HR = 1.53, 95% CI: 1.14 to 2.06). Those with CD8 counts that increased after the start of HAART had a greater risk of failure than those with CD8 counts that decreased or remained the same (HR = 1.59, 95% CI: 1.19 to 2.13). Conclusions: Initial or serial elevated CD8 counts while on HAART or an increase in CD8 counts from HAART initiation may be early warnings for future treatment failure. C1 [Hale, Braden R.] USN, Hlth Res Ctr, San Diego, CA 92106 USA. [Krantz, Elizabeth M.; Hullsiek, Katherine Huppler; Okulicz, Jason F.; Weintrob, Amy C.; Agan, Brian K.; Crum-Cianflone, Nancy F.; Ganesan, Anuradha; Ferguson, Tomas M.; Infect Dis Clin Res Program HIV] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Krantz, Elizabeth M.; Hullsiek, Katherine Huppler] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Okulicz, Jason F.] San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX USA. [Weintrob, Amy C.] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. [Crum-Cianflone, Nancy F.] USN, Infect Dis Clin, San Diego Med Ctr, San Diego, CA 92152 USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Infect Dis Clin, Bethesda, MD USA. [Ferguson, Tomas M.] Tripler Army Med Ctr, Infect Dis Serv, Honolulu, HI 96859 USA. RP Hale, BR (reprint author), USN, Hlth Res Ctr, Code 165,140 Sylvester Rd, San Diego, CA 92106 USA. EM Braden.Hale@med.navy.mil OI Agan, Brian/0000-0002-5114-1669 FU Infectious Disease Clinical Research Program (IDCRP) [IDCRP-000-19]; Department of Defense; National Institute of Allergy and Infectious Diseases, National Institutes of Health [Y1-AI-5072] FX Supported by the Infectious Disease Clinical Research Program (IDCRP; IDCRP-000-19), a Department of Defense program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, under Inter-Agency Agreement Y1-AI-5072. NR 58 TC 9 Z9 9 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD AUG 15 PY 2011 VL 57 IS 5 BP 396 EP 403 DI 10.1097/QAI.0b013e318221c62a PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 800RE UT WOS:000293381300014 PM 21602694 ER PT J AU Stemper, BD Storvik, SG Yoganandan, N Baisden, JL Fijalkowski, RJ Pintar, FA Shender, BS Paskoff, GR AF Stemper, Brian D. Storvik, Steven G. Yoganandan, Narayan Baisden, Jamie L. Fijalkowski, Ronald J. Pintar, Frank A. Shender, Barry S. Paskoff, Glenn R. TI A New PMHS Model for Lumbar Spine Injuries During Vertical Acceleration SO JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME LA English DT Article DE biomechanics; bone; compressibility; fracture; injuries ID THORACOLUMBAR BURST FRACTURES; AIR-FORCE; EJECTION EXPERIENCE; CERVICAL-SPINE; LOADING RATE; END-PLATE; MECHANISM; TRAUMA; COMPRESSION; VERTEBRAE AB Ejection from military aircraft exerts substantial loads on the lumbar spine. Fractures remain common, although the overall survivability of the event has considerably increased over recent decades. The present study was performed to develop and validate a biomechanically accurate experimental model for the high vertical acceleration loading to the lumbar spine that occurs during the catapult phase of aircraft ejection. The model consisted of a vertical drop tower with two horizontal platforms attached to a monorail using low friction linear bearings. A total of four human cadaveric spine specimens (T12-L5) were tested. Each lumbar column was attached to the lower platform through a load cell. Weights were added to the upper platform to match the thorax, head-neck, and upper extremity mass of a 50th percentile male. Both platforms were raised to the drop height and released in unison. Deceleration characteristics of the lower platform were modulated by foam at the bottom of the drop tower. The upper platform applied compressive inertial loads to the top of the specimen during deceleration. All specimens demonstrated complex bending during ejection simulations, with the pattern dependent upon the anterior-posterior location of load application. The model demonstrated adequate inter-specimen kinematic repeatability on a spinal level-by-level basis under different subfailure loading scenarios. One specimen was then exposed to additional tests of increasing acceleration to induce identifiable injury and validate the model as an injury-producing system. Multiple noncontiguous vertebral fractures were obtained at an acceleration of 21 g with 488 g/s rate of onset. This clinically relevant trauma consisted of burst fracture at L1 and wedge fracture at L4. Compression of the vertebral body approached 60% during the failure test, with -6,106 N axial force and 168 Nm flexion moment. Future applications of this model include developing a better understanding of the vertebral injury mechanism during pilot ejection and developing tolerance limits for injuries sustained under a variety of different vertical acceleration scenarios. C1 [Stemper, Brian D.; Storvik, Steven G.; Yoganandan, Narayan; Baisden, Jamie L.; Fijalkowski, Ronald J.; Pintar, Frank A.] Med Coll Wisconsin, Dept Neurosurg, Milwaukee, WI 53226 USA. [Stemper, Brian D.; Storvik, Steven G.; Yoganandan, Narayan; Pintar, Frank A.] Marquette Univ, Dept Biomed Engn, Milwaukee, WI 53201 USA. [Stemper, Brian D.; Storvik, Steven G.; Yoganandan, Narayan; Baisden, Jamie L.; Pintar, Frank A.] Vet Affairs Med Ctr, Milwaukee, WI 53295 USA. [Shender, Barry S.; Paskoff, Glenn R.] USN, Air Warfare Ctr, Div Aircraft, Patuxent River, MD 20670 USA. RP Stemper, BD (reprint author), Med Coll Wisconsin, Dept Neurosurg, Milwaukee, WI 53226 USA. EM bstemper@mcw.edu OI Storvik, Steven/0000-0002-6741-3198 FU Office of Naval Research through Naval Air Warfare Center Aircraft Division [N00421-10-C-0049]; Department of Veterans Affairs Medical Research FX This research was supported in part by the Office of Naval Research through Naval Air Warfare Center Aircraft Division Contract N00421-10-C-0049 and the Department of Veterans Affairs Medical Research. NR 56 TC 9 Z9 10 U1 2 U2 16 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0148-0731 J9 J BIOMECH ENG-T ASME JI J. Biomech. Eng.-Trans. ASME PD AUG PY 2011 VL 133 IS 8 AR 081002 DI 10.1115/1.4004655 PG 9 WC Biophysics; Engineering, Biomedical SC Biophysics; Engineering GA 825NN UT WOS:000295285600002 PM 21950895 ER PT J AU Mansfield, AJ Bender, RH Hourani, LL Larson, GE AF Mansfield, Alyssa J. Bender, Randall H. Hourani, Laurel L. Larson, Gerald E. TI Suicidal or Self-Harming Ideation in Military Personnel Transitioning to Civilian Life SO SUICIDE AND LIFE-THREATENING BEHAVIOR LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; STUDIES-DEPRESSION SCALE; SUBSTANCE USE DISORDERS; PSYCHOMETRIC PROPERTIES; MAJOR DEPRESSION; VIETNAM VETERANS; PTSD CHECKLIST; PRIMARY-CARE; FIT INDEXES AB Suicides have markedly increased among military personnel in recent years. We used path analysis to examine factors associated with suicidal/self-harming ideation among male Navy and Marine Corps personnel transitioning to civilian life. Roughly 7% of men (Sailors = 5.3%, Marines = 9.0%) reported ideation during the previous 30 days. Results suggest that combat exposure, substance abuse, and resilience are associated with suicidal ideation/self-harming thoughts through the mediation of posttraumatic stress disorder symptoms and/or depression symptoms. Substance abuse plays a moderating role. Resilience had a direct effect only among the Marines. Implications for improving the transition to civilian life are discussed. C1 [Mansfield, Alyssa J.; Bender, Randall H.; Hourani, Laurel L.] RTI Int, Res Triangle Pk, NC 27709 USA. [Mansfield, Alyssa J.] Vet Hlth Adm, Natl Ctr PTSD, Pacific Isl Div, Honolulu, HI USA. [Larson, Gerald E.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. RP Hourani, LL (reprint author), RTI Int, 3040 Cornwallis Rd,POB 12194, Res Triangle Pk, NC 27709 USA. EM hourani@rti.org NR 71 TC 10 Z9 10 U1 8 U2 20 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0363-0234 EI 1943-278X J9 SUICIDE LIFE-THREAT JI Suicide Life-Threat. Behav. PD AUG PY 2011 VL 41 IS 4 BP 392 EP 405 DI 10.1111/j.1943-278X.2011.00039.x PG 14 WC Psychiatry; Psychology, Multidisciplinary SC Psychiatry; Psychology GA 810VX UT WOS:000294157200004 PM 21599725 ER PT J AU Ward, N Tran, A Abad, A Lee, EW Hahn, M Fordan, E Es-Said, OS AF Ward, N. Tran, A. Abad, A. Lee, E. W. Hahn, M. Fordan, E. Es-Said, O. S. TI The Effects of Retrogression and Reaging on Aluminum Alloy 2099 (C458) SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE LA English DT Article DE aluminum-lithium alloys; heat treatable aluminum alloys; retrogression and reaging AB The objective of this study was to investigate the feasibility of performing retrogression and reaging (RRA) heat treatments on 2099 aluminum-lithium alloy. The retrogression temperatures were 200-250 A degrees C and retrogression times were 5-60 min. Half of the samples were exposed to a salt fog environment. Interestingly, the samples exposed to salt spray had consistently higher mechanical tensile properties than those which were not exposed. C1 [Ward, N.; Tran, A.; Es-Said, O. S.] Loyola Marymount Univ, Dept Mech Engn, Los Angeles, CA 90045 USA. [Lee, E. W.] Naval Air Warfare, Naval Air Syst Command, Patuxent River, MD 20670 USA. [Abad, A.; Hahn, M.; Fordan, E.] Northrop Grumman Air Combat Syst, El Segundo, CA 90045 USA. RP Ward, N (reprint author), Loyola Marymount Univ, Dept Mech Engn, Los Angeles, CA 90045 USA. EM oessaid@lmu.edu NR 14 TC 9 Z9 16 U1 0 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9495 J9 J MATER ENG PERFORM JI J. Mater. Eng. Perform. PD AUG PY 2011 VL 20 IS 6 BP 989 EP 996 DI 10.1007/s11665-010-9737-7 PG 8 WC Materials Science, Multidisciplinary SC Materials Science GA 792MN UT WOS:000292749800017 ER PT J AU Ward, N Tran, A Abad, A Lee, EW Hahn, M Fordan, E Es-Said, O AF Ward, N. Tran, A. Abad, A. Lee, E. W. Hahn, M. Fordan, E. Es-Said, O. TI The Effects of Retrogression and Reaging on Aluminum Alloy 2195 SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE LA English DT Article DE aluminum lithium alloys; retrogression and reaging; 2195 and 2099 alloys ID STRESS-CORROSION AB A retrogression and reaging (RRA) treatment was performed on 2195 Al-Li Alloy. The exposure times were from 5 to 60 min, and the temperatures were from 200 to 250 A degrees C. Samples that were exposed to a salt spray test had overall similar mechanical properties as compared to those that were not exposed. The percent elongation, however, was significantly deteriorated due to the salt spray exposure. The mechanical properties of the 2195 samples were compared to those of 2099 samples exposed to similar treatments in an earlier study. C1 [Ward, N.; Tran, A.; Es-Said, O.] Loyola Marymount Univ, Dept Mech Engn, Los Angeles, CA 90045 USA. [Lee, E. W.] Naval Air Warfare, Naval Air Syst Command, Patuxent River, MD 20670 USA. [Fordan, E.] Northrop Grumman Aerosp Syst Air Combat Syst, El Segundo, CA 90045 USA. RP Ward, N (reprint author), Loyola Marymount Univ, Dept Mech Engn, Los Angeles, CA 90045 USA. EM oessaid@lmu.edu NR 24 TC 1 Z9 1 U1 4 U2 12 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9495 J9 J MATER ENG PERFORM JI J. Mater. Eng. Perform. PD AUG PY 2011 VL 20 IS 6 BP 1003 EP 1014 DI 10.1007/s11665-010-9739-5 PG 12 WC Materials Science, Multidisciplinary SC Materials Science GA 792MN UT WOS:000292749800019 ER PT J AU Myers, CA Faix, DJ Blair, PJ AF Myers, Christopher A. Faix, Dennis J. Blair, Patrick J. TI Possible Reduced Effectiveness of the 2009 H1N1 Component of Live, Attenuated Influenza Vaccine SO CLINICAL INFECTIOUS DISEASES LA English DT Letter C1 [Faix, Dennis J.] USN, Febrile Resp Illness Surveillance Team, Febrile Resp Illness Surveillance Grp, Dept Resp Dis Res,Hlth Res Ctr, San Diego, CA 92106 USA. RP Faix, DJ (reprint author), USN, Febrile Resp Illness Surveillance Team, Febrile Resp Illness Surveillance Grp, Dept Resp Dis Res,Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. EM dennis.faix@med.navy.mil RI Valle, Ruben/A-7512-2013 NR 4 TC 5 Z9 5 U1 0 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JUL 15 PY 2011 VL 53 IS 2 BP 207 EP 208 DI 10.1093/cid/cir282 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 796BA UT WOS:000293024000016 PM 21690631 ER PT J AU McInturf, SM Bekkedal, MYV Wilfong, E Arfsten, D Chapman, G Gunasekar, PG AF McInturf, S. M. Bekkedal, M. Y. V. Wilfong, E. Arfsten, D. Chapman, G. Gunasekar, P. G. TI The potential reproductive, neurobehavioral and systemic effects of soluble sodium tungstate exposure in Sprague-Dawley rats SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article DE Tungstate; Health effects; Reproduction; Behavioral study; Rat; Toxicity ID COPPER AB The debate on tungsten (W) is fostered by its continuous usage in military munitions. Reports demonstrate W solubilizes in soil and can migrate into drinking water supplies and, therefore, is a potential health risk to humans. This study evaluated the reproductive, systemic and neurobehavioral effects of sodium tungstate (NaW) in rats following 70 days of daily pre-and postnatal exposure via oral gavage to 5, 62.5 and 125 mg/kg/day of NaW through mating, gestation and weaning (PND 0-20). Daily administration of NaW produced no overt evidence of toxicity and had no apparent effect on mating success or offspring physical development. Distress vocalizations were elevated in F(1) offspring from the high dose group, whereas righting reflex showed unexpected sex differences where males demonstrated faster righting than females; however, the effects were not dose-dependent. Locomotor activity was affected in both low and high-dose groups of F(1) females. Low-dose group showed increased distance traveled, more time in ambulatory movements and less time in stereotypic behavior than controls or high dose animals. The high-dose group had more time in stereotypical movements than controls, and less time resting than controls and the lowest exposure group. Maternal retrieval was not affected by NaW exposure. Tungsten analysis showed a systemic distribution of NaW in both parents and offspring, with preferential uptake within the immune organs, including the femur, spleen and thymus. Histopathological evidence suggested no severe chronic injury or loss of function in these organs. However, the heart showed histological lesions, histiocytic inflammation from minimal to mild with cardiomyocyte degeneration and necrosis in several P(0) animals of 125 mg NaW dose group. The result of this study suggests that pre and postnatal exposure to NaW may produce subtle neurobehavioral effects in offspring related to motor activity and emotionality. Published by Elsevier Inc. C1 [McInturf, S. M.; Chapman, G.; Gunasekar, P. G.] Naval Med Res Unit Dayton NAMRU, Wright Patterson AFB, OH USA. [Bekkedal, M. Y. V.] Two Steps Forward LLC, Sun Prairie, WI USA. [Wilfong, E.] USN Acad, Annapolis, MD USA. [Arfsten, D.] Naval Air Stn, Navy Drug Screening Lab, Jacksonville, FL USA. RP Gunasekar, PG (reprint author), Naval Med Res Unit Dayton NAMRU, Wright Patterson AFB, OH USA. EM palur.gunasekar@wpafb.af.mil FU Defense Health Programs (DHP) reimbursable Work Unit [60768] FX This work was supported by Defense Health Programs (DHP) reimbursable Work Unit # 60768. The animals used in this study were handled in accordance with the principles stated in the Guide for the Care and Use of Laboratory Animals, National Research Council, 1996, and the Animal Welfare Act of 1996, as amended. The authors gratefully acknowledge support from vivarium, WPAFB for animal facility. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect those of the Defense Health Program. NR 17 TC 12 Z9 12 U1 2 U2 7 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0041-008X J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD JUL 15 PY 2011 VL 254 IS 2 SI SI BP 133 EP 137 DI 10.1016/j.taap.2010.04.021 PG 5 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 793HJ UT WOS:000292810700006 PM 21296100 ER PT J AU Gunasekar, PG Stanek, LW AF Gunasekar, Palur G. Stanek, Lindsay W. TI Advances in exposure and toxicity assessment of particulate matter: An overview of presentations at the 2009 Toxicology and Risk Assessment Conference SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article DE Particulate matter; Tungsten alloys; Middle East dust; Aerosol collection; Epidemiology; Health effect AB The 2009 Toxicology and Risk Assessment Conference (TRAC) session on "Advances in Exposure and Toxicity Assessment of Particulate Matter" was held in April 2009 in West Chester, OH. The goal of this session was to bring together toxicology, geology and risk assessment experts from the Department of Defense and academia to examine issues in exposure assessment and report on recent epidemiological findings of health effects associated with particulate matter (PM) exposure. Important aspects of PM exposure research are to detect and monitor low levels of PM with various chemical compositions and to assess the health risks associated with these exposures. As part of the overall theme, some presenters discussed collection methods for sand and dust from Iraqi and Afghanistan regions, health issues among deployed personnel, and future directions for risk assessment research among these populations. The remaining speakers focused on the toxicity of ultrafine PM and the characterization of aerosols generated during ballistic impacts of tungsten heavy alloys. Published by Elsevier Inc. C1 [Gunasekar, Palur G.] Naval Hlth Res Ctr Detachment, Environm Hlth Effects Lab, Wright Patterson AFB, Dayton, OH USA. [Stanek, Lindsay W.] US EPA, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA. RP Gunasekar, PG (reprint author), Naval Hlth Res Ctr Detachment, Environm Hlth Effects Lab, Wright Patterson AFB, Dayton, OH USA. EM palur.gunasekar@wpafb.af.mil; Stanek.Lindsay@epa.gov NR 4 TC 3 Z9 3 U1 2 U2 14 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0041-008X J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD JUL 15 PY 2011 VL 254 IS 2 SI SI BP 141 EP 144 DI 10.1016/j.taap.2010.10.020 PG 4 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 793HJ UT WOS:000292810700008 PM 21034760 ER PT J AU Smith, TC AF Smith, Tyler C. CA Millennium Cohort Study Team TI Linking Exposures and Health Outcomes to a Large Population-Based Longitudinal Study: The Millennium Cohort Study SO MILITARY MEDICINE LA English DT Article ID GULF-WAR VETERANS; DEPARTMENT-OF-DEFENSE; POSTTRAUMATIC-STRESS-DISORDER; MILITARY SERVICE MEMBERS; SELF-REPORTED SYMPTOMS; US MILITARY; COMBAT DEPLOYMENT; FUNCTIONAL HEALTH; MENTAL-DISORDERS; ANTHRAX VACCINE AB Objective: To describe current efforts and future potential for understanding long-term health of military service members by linking the Millennium Cohort Study data to exposures and health outcomes. Methods: The Millennium Cohort Study launched in 2001, before September 11 and the start of combat operations in Afghanistan and Iraq. Other substantial Department of Defense (DoD) health, personnel, and exposure databases are maintained in electronic form and may be linked by personal identifiers. Results: More than 150,000 consenting members comprise the Millennium Cohort from all services, and include active duty, Reserve, and National Guard current and past members, and represent demographic, occupational, military, and health characteristics of the U.S. military. These prospective data offer symptom assessment, behavioral health, and self-reported exposures that may complement and fill gaps in capability presented by other DoD electronic health and exposure data. Conclusions: In conjunction with Millennium Cohort survey data, prospective individual-level exposure and health outcome assessment is crucial to understand and quantify any long-term health outcomes potentially associated with unique military occupational exposures. C1 [Smith, Tyler C.; Millennium Cohort Study Team] Naval Hlth Res Ctr, Dept Deployment Hlth Res, San Diego, CA 92106 USA. RP Smith, TC (reprint author), Naval Hlth Res Ctr, Dept Deployment Hlth Res, 140 Sylvester Rd, San Diego, CA 92106 USA. FU Department of Defense FX This work represents report 10-37, supported by the Department of Defense, under work unit no. 60002. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of the Army, Department of the Air Force, Department of Defense, Department of Veterans Affairs, or the U.S. Government. This research has been conducted in compliance with all applicable federal regulations governing the protection of human subjects in research (Protocol NHRC.2000.0007). NR 75 TC 5 Z9 6 U1 3 U2 13 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2011 VL 176 IS 7 SU S BP 56 EP 63 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 792XQ UT WOS:000292784100015 PM 21916332 ER PT J AU MacGregor, AJ Dougherty, AL Galarneau, MR AF MacGregor, Andrew J. Dougherty, Amber L. Galarneau, Michael R. TI Injury-Specific Correlates of Combat-Related Traumatic Brain Injury in Operation Iraqi Freedom SO JOURNAL OF HEAD TRAUMA REHABILITATION LA English DT Article DE combat; military; traumatic brain injury ID SEVERITY SCORE; REGISTRY; AFGHANISTAN; WARS; HEAD AB Background: The prevalence of traumatic brain injury (TBI) has increased during the wars in Iraq and Afghanistan compared with 20th century military conflicts. The aim of this study was to elucidate injury-specific correlates of combat-related TBI that have yet to be clearly defined. Participants: Predominately Marine US service members who sustained brain injuries in Iraq between March 2004 and April 2008 identified from clinical records completed in the theater of combat operations (n = 2074). Main Outcome Measures: Severity of TBI was classified as mild, moderate, or severe. Injury-specific factors, such as injury mechanism and type, were abstracted from the clinical records and were compared with severity of TBI. Results: Of all TBIs observed in the sample, 89% were mild. Higher severity of TBI was associated with an increased likelihood of sustaining the injury by gunshot and a lower likelihood of helmet use. Improvised explosive devices were associated with a preponderance of mild TBIs, and frequency of injuries in locations in addition to the head was highest among those with moderate and severe TBIs. Concomitant injuries to the spine/back were associated with blast injury mechanisms. Conclusions: Most incidents of TBI occurring during Operation Iraqi Freedom are mild in severity and a result of blast mechanisms. Multiple injuries were common, particularly as severity of TBI increased. Further research is needed to determine effects of combat-related TBI on rehabilitative and adverse health outcomes. C1 [MacGregor, Andrew J.; Dougherty, Amber L.; Galarneau, Michael R.] USN, Hlth Res Ctr, San Diego, CA 92106 USA. RP Dougherty, AL (reprint author), USN, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. EM amber.dougherty@med.navy.mil FU US Navy Medicine Bureau of Medicine and Surgery, Washington, DC [60808] FX This work was supported by the US Navy Medicine Bureau of Medicine and Surgery, Washington, DC, under Work Unit No. 60808. The views and opinions expressed herein are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, or the US Government. This research has been conducted in compliance with all applicable federal regulations governing the protection of human subjects in research. NR 23 TC 24 Z9 24 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0885-9701 J9 J HEAD TRAUMA REHAB JI J. Head Trauma Rehabil. PD JUL-AUG PY 2011 VL 26 IS 4 BP 312 EP 318 DI 10.1097/HTR.0b013e3181e94404 PG 7 WC Clinical Neurology; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA 789FZ UT WOS:000292501700008 PM 20808241 ER PT J AU Mohr, SB Garland, CF Gorham, ED Grant, WB Garland, FC AF Mohr, Sharif B. Garland, Cedric F. Gorham, Edward D. Grant, William B. Garland, Frank C. TI Ultraviolet B and Incidence Rates of Leukemia Worldwide SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID 1-ALPHA,25-DIHYDROXYVITAMIN D-3-26,23-LACTONE ANALOGS; GROWTH-FACTOR-I; VITAMIN-D; MYELOID-LEUKEMIA; CANCER MORTALITY; COLON CANCER; CHILDHOOD LEUKEMIA; OVARIAN-CANCER; RETINOIC ACID; UNITED-STATES AB Background: Recent research has suggested a relationship between vitamin D deficiency and risk of leukemia. Purpose: Using data from the UN cancer database, GLOBOCAN, this study will determine whether a relationship exists for latitude and ultraviolet B (UVB) irradiance with incidence rates of leukemia in 175 countries. Methods: Multiple regression was used to analyze the independent association between UVB and age-adjusted incidence rates of leukemia in 139 countries in 2002. This study controlled for dietary data on intake of energy from animal sources and per capita healthcare expenditures. The analyses were performed in 2009. Results: People residing in the highest-latitude countries had the highest rates of leukemia in both men (R(2)=0.34, p<0.0001) and women (R(2)=0.24, p<0.0001). In men, UVB was independently inversely associated with leukemia incidence rates (p <= 0.001), whereas animal energy consumption (p=0.02) and per capita healthcare expenditures (p <= 0.0001) were independently positively associated (R(2) for model=0.61, p <= 0.0001). In women, UVB adjusted for cloud cover was independently inversely associated with leukemia incidence rates (p <= 0.01), whereas animal energy consumption (p <= 0.05) and per capita healthcare expenditures (p=0.0002) were independently positively associated (R(2) for model=0.51, p<0.0001). Conclusions: Countries with low UVB had higher age-adjusted incidence rates of leukemia. This suggests the possibility that low serum 25-hydroxyvitamin D status, because of lower levels of UVB, somehow might predict the development of leukemia. (Am J Prev Med 2011; 41(1): 68-74) (C) 2011 Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine. C1 [Mohr, Sharif B.; Garland, Cedric F.; Gorham, Edward D.; Garland, Frank C.] Univ Calif San Diego, Dept Family & Prevent Med, Div Epidemiol, La Jolla, CA 92093 USA. [Mohr, Sharif B.; Garland, Cedric F.; Gorham, Edward D.] USN, Hlth Res Ctr, Dept Hlth Sci & Epidemiol, San Diego, CA 92152 USA. [Garland, Frank C.] USN, Hlth Res Ctr, Off Tech Director, San Diego, CA 92152 USA. [Grant, William B.] Sunlight Nutr & Hlth Res Ctr, San Francisco, CA USA. RP Garland, CF (reprint author), Univ Calif San Diego, Dept Family & Prevent Med, Div Epidemiol, 9500 Gilman Dr, La Jolla, CA 92093 USA. EM cgarland@ucsd.edu RI Grant, William/B-8311-2009 OI Grant, William/0000-0002-1439-3285 FU Hershey Medical Center, Hershey PA through the Department of the Navy, Bureau of Medicine and Surgery at the Naval Health Research Center (San Diego CA) [60126] FX This research was supported by a Congressional allocation to the Penn State Cancer Institute of the Hershey Medical Center, Hershey PA, through the Department of the Navy, Bureau of Medicine and Surgery, under Work Unit No. 60126 at the Naval Health Research Center (San Diego CA). The views expressed in this report are those of the authors and do not represent an official position of the Department of the Navy, Department of Defense, or the U.S. Government. NR 50 TC 9 Z9 9 U1 0 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD JUL PY 2011 VL 41 IS 1 BP 68 EP 74 DI 10.1016/j.amepre.2011.04.003 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 775OC UT WOS:000291468700011 PM 21665065 ER PT J AU Hirschel, M Gangemi, JD McSharry, J Myers, C AF Hirschel, Mark Gangemi, J. David McSharry, James Myers, Chris TI Novel Uses for Hollow Fiber Bioreactors SO GENETIC ENGINEERING & BIOTECHNOLOGY NEWS LA English DT Article C1 [Hirschel, Mark; Gangemi, J. David] Biovest Int, Tampa, FL 33606 USA. [McSharry, James] Ordway Res Inst, Albany, NY USA. [Myers, Chris] Naval Hlth Res Ctr, Dept Resp Dis Res, San Diego, CA USA. RP Hirschel, M (reprint author), Biovest Int, Tampa, FL 33606 USA. EM mhirschel@biovest.com NR 0 TC 3 Z9 3 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1935-472X J9 GENET ENG BIOTECHN N JI Genet. Eng. Biotechnol. News PD JUN 15 PY 2011 VL 31 IS 12 BP 42 EP + PG 2 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA 779EZ UT WOS:000291762200012 ER PT J AU Dawood, FS Ambrose, JF Russell, BP Hawksworth, AW Winchell, JM Glass, N Thurman, K Soltis, MA McDonough, E Warner, AK Weston, E Clemmons, NS Rosen, J Mitchell, SL Faix, DJ Blair, PJ Moore, MR Lowery, J AF Dawood, Fatimah S. Ambrose, John F. Russell, Bruce P. Hawksworth, Anthony W. Winchell, Jonas M. Glass, Nina Thurman, Kathleen Soltis, Michele A. McDonough, Erin Warner, Agnes K. Weston, Emily Clemmons, Nakia S. Rosen, Jennifer Mitchell, Stephanie L. Faix, Dennis J. Blair, Patrick J. Moore, Matthew R. Lowery, John TI Outbreak of Pneumonia in the Setting of Fatal Pneumococcal Meningitis among US Army Trainees: Potential Role of Chlamydia pneumoniae Infection SO BMC INFECTIOUS DISEASES LA English DT Article DE Pneumonia; pneumococcal; Chlamydophila; pneumoniae; Military Personnel ID REAL-TIME PCR; STREPTOCOCCUS-PNEUMONIAE; MYCOPLASMA-PNEUMONIAE; MILITARY PERSONNEL; EPIDEMIC; FINLAND; COMMUNITY AB Background: Compared to the civilian population, military trainees are often at increased risk for respiratory infections. We investigated an outbreak of radiologically-confirmed pneumonia that was recognized after 2 fatal cases of serotype 7F pneumococcal meningitis were reported in a 303-person military trainee company (Alpha Company). Methods: We reviewed surveillance data on pneumonia and febrile respiratory illness at the training facility; conducted chart reviews for cases of radiologically-confirmed pneumonia; and administered surveys and collected nasopharyngeal swabs from trainees in the outbreak battalion (Alpha and Hotel Companies), associated training staff, and trainees newly joining the battalion. Results: Among Alpha and Hotel Company trainees, the average weekly attack rates of radiologically-confirmed pneumonia were 1.4% and 1.2% (most other companies at FLW: 0-0.4%). The pneumococcal carriage rate among all Alpha Company trainees was 15% with a predominance of serotypes 7F and 3. Chlamydia pneumoniae was identified from 31% of specimens collected from Alpha Company trainees with respiratory symptoms. Conclusion: Although the etiology of the outbreak remains unclear, the identification of both S. pneumoniae and C. pneumoniae among trainees suggests that both pathogens may have contributed either independently or as cofactors to the observed increased incidence of pneumonia in the outbreak battalion and should be considered as possible etiologies in outbreaks of pneumonia in the military population. C1 [Dawood, Fatimah S.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Influenza Epidemiol & Prevent Branch,Influenza Di, Atlanta, GA 30333 USA. [Winchell, Jonas M.; Glass, Nina; Thurman, Kathleen; Warner, Agnes K.; Weston, Emily; Rosen, Jennifer; Mitchell, Stephanie L.; Moore, Matthew R.] Ctr Dis Control & Prevent, Resp Dis Branch, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Ambrose, John F.; Soltis, Michele A.; Clemmons, Nakia S.] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. [Russell, Bruce P.] Gen Leonard Wood Army Community Hosp, Div Prevent Med, Ft Leonard Wood, MO 65473 USA. [Hawksworth, Anthony W.; McDonough, Erin; Faix, Dennis J.; Blair, Patrick J.] USN, Hlth Res Ctr, San Diego, CA 92106 USA. RP Dawood, FS (reprint author), Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Influenza Epidemiol & Prevent Branch,Influenza Di, 1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM fdawood@cdc.gov; zdn4@cdc.gov RI Valle, Ruben/A-7512-2013; OI Glass, Nina/0000-0002-6821-4289 NR 19 TC 11 Z9 11 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD JUN 2 PY 2011 VL 11 AR 157 DI 10.1186/1471-2334-11-157 PG 9 WC Infectious Diseases SC Infectious Diseases GA 783KN UT WOS:000292081300001 PM 21635754 ER PT J AU Shah, A Stemper, B Yoganandan, N Shender, B AF Shah, Alok Stemper, Brian Yoganandan, Narayan Shender, Barry TI PRESSURE PROFILES AND ATTENUATION CHARACTERISTICS OF SHOCKWAVES USING POST MORTEM HUMAN SUBJECT MODEL FOR BLAST-INDUCED MILD TRAUMATIC BRAIN INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 29th Annual National Neurotrauma Symposium CY JUL 10-13, 2011 CL Hollywood Beach, FL C1 [Shah, Alok; Stemper, Brian; Yoganandan, Narayan; Shender, Barry] Med Coll Wisconsin, Milwaukee, WI 53226 USA. [Shender, Barry] USN, Air Warfare Ctr, Div Aircraft, Patuxent River, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN PY 2011 VL 28 IS 6 BP A59 EP A59 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 788PT UT WOS:000292457600191 ER PT J AU Abdel-Hafez, AA Brodt, MW Carney, JR Lightstone, JM AF Abdel-Hafez, Ahmed A. Brodt, Matthew W. Carney, Joel R. Lightstone, James M. TI Laser dispersion and ignition of metal fuel particles SO REVIEW OF SCIENTIFIC INSTRUMENTS LA English DT Article ID PRESSED LEAD AZIDE; ALUMINUM PARTICLES; FLAME PROPAGATION; CARBON-DIOXIDE; DUST CLOUDS; COMBUSTION; INITIATION; SIZE; SPEED; AIR AB The development of a laser-shock technique for dispersing Al metal fuel particles at velocities approaching those expected in a detonating explosive is discussed. The technique is described in detail by quantifying how air drag affects the temporal variation of the velocity of the dispersed particle plume. The effect of particle size is incorporated by examining various poly-dispersed commercial Al powders at different dispersion velocities (390-630 m/s). The technique is finally tested within a preliminary study of particle ignition delay and burn time, where the effect of velocity is highlighted for different particle sizes. It was found that plume velocity exhibits a modified exponential temporal profile, where smaller particles are more susceptible to air drag than larger ones. Moreover, larger particles exhibit longer ignition delays and burn times than smaller ones. The velocity of a particle was found to significantly affect its ignition delay, burn time, and combustion temperature, especially for particles in the diffusion-controlled regime. Shorter ignition delays and burn times and lower temperatures were observed at higher particle velocities. The utility of this technique as a combustion screening test for future, novel fuels is discussed. (C) 2011 American Institute of Physics. [doi:10.1063/1.3598341] C1 [Abdel-Hafez, Ahmed A.; Carney, Joel R.; Lightstone, James M.] Naval Surface Warfare Ctr, Indian Head Div, Indian Head, MD 20640 USA. [Brodt, Matthew W.] Univ Virginia, Dept Chem Engn, Charlottesville, VA 22904 USA. RP Lightstone, JM (reprint author), Naval Surface Warfare Ctr, Indian Head Div, Indian Head, MD 20640 USA. EM james.lightstone@navy.mil FU Office of Naval Research; American Society for Engineering Education (ASEE) through NSWC FX Partial funding was received from the Office of Naval Research High-Energy Conventional Explosives Program. A.A.A. would like to thank the American Society for Engineering Education (ASEE) for their support through the NSWC Postdoctoral Fellowship. The authors would like to acknowledge Valimet Inc. for providing the Al powders examined in this study. The help provided by Colin Roberts and David Jackman at IHD NSWC in sample preparation is much appreciated. NR 68 TC 6 Z9 6 U1 0 U2 6 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0034-6748 EI 1089-7623 J9 REV SCI INSTRUM JI Rev. Sci. Instrum. PD JUN PY 2011 VL 82 IS 6 AR 064101 DI 10.1063/1.3598341 PG 11 WC Instruments & Instrumentation; Physics, Applied SC Instruments & Instrumentation; Physics GA 786US UT WOS:000292334000042 PM 21721708 ER PT J AU Yungwirth, CJ O'Connor, J Zakraysek, A Deshpande, VS Wadley, HNG AF Yungwirth, Christian J. O'Connor, John Zakraysek, Alan Deshpande, Vikram S. Wadley, Haydn N. G. TI Explorations of Hybrid Sandwich Panel Concepts for Projectile Impact Mitigation SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article ID CERAMIC TARGETS; PLATES; PENETRATION; MODEL; DEFORMATION; MECHANICS; FRACTURE; ARMORS AB Previous studies have shown that while stainless-steel sandwich panels with pyramidal truss cores have a superior blast resistance to monolithic plates of equal mass per unit area, their ballistic performance is similar to their monolithic counterparts. Here, we explore concepts to enhance the ballistic resistance without changing the volumetric efficiency of the panels by filling the spaces within the core with combinations of polyurethane, alumina prisms, and aramid fiber textiles. The addition of the polyurethane does not enhance the ballistic limit compared with the equivalent monolithic steel plate, even when aramids are added. This poor performance occurs because the polymer is penetrated by a hole enlargement mechanism which does not result in significant projectile deformation or load spreading and engagement of the steel face sheets. By contrast, ceramic inserts deform and erode the projectile and also comminute the ceramic. The ceramic communition (and resultant dilation) results in stretching of both steel face sheets and leads to significant energy dissipation. The ballistic limit of this hybrid is about twice that of the equivalent monolithic steel plate. The addition of a Kevlar fabric to the ceramic hybrid is shown to not significantly change the ballistic limit but does reduce the residual velocities of the debris. C1 [Yungwirth, Christian J.; Wadley, Haydn N. G.] Univ Virginia, Sch Engn & Appl Sci, Dept Mat Sci & Engn, Charlottesville, VA 22903 USA. [O'Connor, John; Zakraysek, Alan] Naval Surface Warfare Ctr, Indian Head, MD 20640 USA. [Deshpande, Vikram S.] Univ Cambridge, Dept Engn, Cambridge CB2 1PZ, England. RP Wadley, HNG (reprint author), Univ Virginia, Sch Engn & Appl Sci, Dept Mat Sci & Engn, Charlottesville, VA 22903 USA. EM haydn@virginia.edu RI Deshpande, Vikram/C-6750-2013 OI Deshpande, Vikram/0000-0003-3899-3573 FU Office of Naval Research (ONR) [N00014-04-1-0299, N00014-01-1-1051] FX The ballistic measurements were supported by the Defense Advanced Research Projects Agency and the Office of Naval Research under Grant number N00014-04-1-0299 (Dr. Leo Christodoulou was its program manager). The analysis work has been performed as part of the Ultralight Metallic Panels with Textile Cores Designed for Blast Mitigation and Load Retention program conducted by the University of Virginia and Cambridge University and funded by the Office of Naval Research (ONR) under Grant number N00014-01-1-1051 (Dr. David Shifler was the program manager). NR 30 TC 12 Z9 14 U1 4 U2 20 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-7820 EI 1551-2916 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD JUN PY 2011 VL 94 SU 1 BP S62 EP S75 DI 10.1111/j.1551-2916.2011.04501.x PG 14 WC Materials Science, Ceramics SC Materials Science GA 785EC UT WOS:000292209200007 ER PT J AU Leap, MJ Rankin, J Harrison, J Hackel, L Nemeth, J Candela, J AF Leap, M. J. Rankin, J. Harrison, J. Hackel, L. Nemeth, J. Candela, J. TI Effects of laser peening on fatigue life in an arrestment hook shank application for Naval aircraft SO INTERNATIONAL JOURNAL OF FATIGUE LA English DT Article DE Laser peening; Low cycle fatigue; Arrestment hook shank; Hy-Tuf; Ferrium S53 AB Laser peening is evaluated relative to and in combination with other means of improving fatigue resistance in a particularly severe arrestment hook shank application for a carrier-based Naval aircraft. A large-scale test specimen was designed and manufactured from Hy-Tuf steel to geometrically simulate conditions in the arrestment hook shank, and fatigue tests were conducted on peened specimens under conditions of spectrum loading that simulate aircraft arrestments. Laser peening substantially increases the resistance to crack initiation relative to conventional shot peening. A change to a higher-strength steel, Ferrium S53, significantly increases the crack initiation life of both conventionally shot peened and laser peened specimens, with the latter exhibiting the highest levels of crack initiation life for all conditions evaluated in this test program. Proof loading at levels above the design limit load, conducted before the peening operation, substantially increases the crack initiation life of conventionally shot peened specimens. In contrast, proof loading does not provide additional improvements in the fatigue life of laser peened specimens since the depth of plasticity due to proof loading is similar in magnitude to the depth of residual compressive stress introduced by laser peening. Finally, limited test results suggest that repeated laser peening over the life of a component may maximize or even extend crack initiation life; however, a significant amount of testing would be required to determine the processing parameters that maximize the efficacy of this approach to extending fatigue life. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Nemeth, J.] Concurrent Technol Corp, Johnstown, PA USA. [Leap, M. J.; Candela, J.] USN, Air Warfare Ctr, Div Aircraft, Patuxent River, MD USA. [Rankin, J.; Hackel, L.] Met Improvement Co, Livermore, CA USA. [Harrison, J.] Met Improvement Co, Wellington, KS USA. RP Nemeth, J (reprint author), Concurrent Technol Corp, Johnstown, PA USA. EM jpnemeth@aol.com FU Concurrent Technologies Corporation [N00014-06-D-0048] FX This article was prepared by the Navy Metalworking Center, operated by Concurrent Technologies Corporation, under Contract No. N00014-06-D-0048 to the Office of Naval Research as part of the Navy ManTech Program. Approved for public release; distribution is unlimited. NR 12 TC 4 Z9 7 U1 2 U2 15 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0142-1123 J9 INT J FATIGUE JI Int. J. Fatigue PD JUN PY 2011 VL 33 IS 6 BP 788 EP 799 DI 10.1016/j.ijfatigue.2010.12.016 PG 12 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 739QH UT WOS:000288732400004 ER PT J AU Lee, EU Taylor, RE AF Lee, E. U. Taylor, R. E. TI Fatigue behavior of aluminum alloys under biaxial loading SO ENGINEERING FRACTURE MECHANICS LA English DT Article; Proceedings Paper CT 9th International Conference on Multiaxial Fatigue and Fracture CY JUN 07-09, 2010 CL Parma, ITALY DE Biaxiality; Fatigue life; Crack path; Fatigue crack growth; In-phase and out-of-phase loading ID ANGLED CRACK PROBLEM; STRESS; FRACTURE; GROWTH; PROPAGATION; STABILITY; PATHS AB The biaxiality effect, especially the effect of non-singular stress cycling, on the fatigue behavior was studied, employing cruciform specimens of aluminum alloys 1100-H14 and 7075-T651. The specimens, containing a transverse or a 45 degrees inclined center notch, were subjected to in-phase (IP) or 100% out-of-phase (hereinafter referred to as "out-of-phase or OP") loading of stress ratio 0.1 in air. The biaxiality ratio lambda ranged from 0 to 1.5, and 3 levels of stress were applied. It was observed that: (1) at a given lambda a lower longitudinal stress induced a longer fatigue life under IP and OP loading, and the fatigue life was longer under IP loading, (2) the fatigue crack path profile was influenced by lambda, phase angle (0 degrees or 180 degrees), and initial center notch (transverse or 45 degrees inclined); (3) the fatigue crack path profiles, predicted analytically and determined experimentally, had similar features for the specimens with a transverse center notch under IP loading; and (4) the fatigue crack growth rate was lower and the fatigue life longer for a greater lambda under IP loading, whereas it changed little with change in lambda under OP loading. These results demonstrate that non-singular stress cycling affects the biaxial fatigue behavior of aluminum alloys 1100-H14 and 7065-T651 under IP and OP loading. Published by Elsevier Ltd. C1 [Lee, E. U.; Taylor, R. E.] USN, Air Warfare Ctr, Div Aircraft, Patuxent River, MD USA. RP Lee, EU (reprint author), USN, Air Warfare Ctr, Div Aircraft, Patuxent River, MD USA. EM eun.lee@navy.mil NR 24 TC 7 Z9 8 U1 0 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0013-7944 J9 ENG FRACT MECH JI Eng. Fract. Mech. PD MAY PY 2011 VL 78 IS 8 SI SI BP 1555 EP 1564 DI 10.1016/j.engfracmech.2010.11.005 PG 10 WC Mechanics SC Mechanics GA 792AY UT WOS:000292714100005 ER PT J AU Macera, CA Aralis, H MacGregor, A Rauh, MJ Heltemes, K Han, P Galarneau, MR AF Macera, Caroline A. Aralis, Hilary MacGregor, Andrew Rauh, Mitchell J. Heltemes, Kevin Han, Peggy Galarneau, Michael R. TI Weight Changes Among Male Navy Personnel Deployed to Iraq or Kuwait in 2005-2008 SO MILITARY MEDICINE LA English DT Article ID MILITARY PERSONNEL; BODY-WEIGHT; DUTY; COHORT; HEALTH; FREEDOM; FITNESS; IMPACT AB The objective of this study was to identify changes in weight that occurred during deployment to Iraq or Kuwait between 2005 and 2008. Data on length and type of deployment among 16,365 male U.S. Navy personnel were combined with weight measurements before and after deployment from the Physical Readiness Information Management System. Weight measurements were available for 10,886 men who did not exceed Navy weight recommendations before deployment. In general, weight increased after deployment and, for those who did not exceed Navy recommendations before deployment, factors associated with weight gain included being enlisted and having a deployment longer than 228 days. Among 1,108 men with 2 deployments, a dwell time shorter than the combined deployed time was a risk factor for weight gain during the second deployment. Future studies should explore the combined effects of long deployments and short dwell times in maintaining the readiness of military personnel. C1 [Macera, Caroline A.; Aralis, Hilary; MacGregor, Andrew; Rauh, Mitchell J.; Heltemes, Kevin; Han, Peggy; Galarneau, Michael R.] USN, Hlth Res Ctr, San Diego, CA 92106 USA. RP Macera, CA (reprint author), USN, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. FU Department of Defense [60818] FX This work was supported by the Department of Defense under work unit no.60818. NR 11 TC 3 Z9 3 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 2011 VL 176 IS 5 BP 500 EP 506 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 792XM UT WOS:000292783700009 PM 21634293 ER PT J AU Enright, MP Chan, KS Moody, JP Golder, PJ Chandra, R Pentz, AC AF Enright, Michael P. Chan, Kwai S. Moody, Jonathan P. Golder, Patrick J. Chandra, Ramesh Pentz, Alan C. TI Influence of Random Residual Stress on Fretting Fatigue SO AIAA JOURNAL LA English DT Article; Proceedings Paper CT AIAA 11th Non-Deterministic Approaches Conference CY MAY 04-07, 2009 CL Palm Springs, CA SP AIAA ID HIGH-CYCLE FATIGUE; FRACTURE-MECHANICS APPROACH; DESIGN; METHODOLOGY; PREDICTION AB Probabilistic risk assessment has increasingly been adopted by certification agencies to address the inherent uncertainties in fatigue crack nucleation and;growth processes. Fretting fatigue is a significant damage source for aircraft gas turbine engine components. When present, it can reduce component lives by 40 to 60 percent or more. Surface treatments introduce compressive residual stresses that have the potential to substantially increase component lifetimes. In this paper, an approach is presented for estimating the fretting fatigue risk reduction associated with surface treatment of an actual military engine disk under real-life loading conditions. Residual stresses associated with surface treatment are based on values reported in the literature. A probabilistic model of the fretting process is calibrated based on available failure data and used to quantify the influence of surface treatment on the probability of fracture. C1 [Enright, Michael P.; Chan, Kwai S.; Moody, Jonathan P.] SW Res Inst, San Antonio, TX 78238 USA. [Golder, Patrick J.] USAF, Res Lab, Met Ceram & NDE Div, Wright Patterson AFB, OH 45433 USA. [Chandra, Ramesh; Pentz, Alan C.] NAVAIR, Struct Integr Branch, Patuxent River, MD 20670 USA. RP Enright, MP (reprint author), SW Res Inst, 6220 Culebra Rd, San Antonio, TX 78238 USA. NR 37 TC 0 Z9 0 U1 0 U2 12 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0001-1452 J9 AIAA J JI AIAA J. PD MAY PY 2011 VL 49 IS 5 BP 881 EP 889 DI 10.2514/1.45774 PG 9 WC Engineering, Aerospace SC Engineering GA 770FI UT WOS:000291072000001 ER PT J AU Asvestas, JS AF Asvestas, John S. TI Computing the solid angle subtended by a planar figure (vol 33, pg 4055, 1994) SO OPTICAL ENGINEERING LA English DT Correction C1 USN, Naval Air Syst Command, Patuxent River, MD 20670 USA. RP Asvestas, JS (reprint author), USN, Naval Air Syst Command, B 2187,S 2190, Patuxent River, MD 20670 USA. EM john.asvestas@navy.mil NR 1 TC 0 Z9 0 U1 1 U2 3 PU SPIE-SOC PHOTOPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD MAY PY 2011 VL 50 IS 5 AR 059801 DI 10.1117/1.3582189 PG 1 WC Optics SC Optics GA 769NW UT WOS:000291024100054 ER PT J AU Doucet, JJ Galarneau, MR Potenza, BM Bansal, V Lee, JG Schwartz, AK Dougherty, AL Dye, J Hollingsworth-Fridlund, P Fortlage, D Coimbra, R AF Doucet, Jay J. Galarneau, Michael R. Potenza, Bruce M. Bansal, Vishal Lee, Jeanne G. Schwartz, Alexandra K. Dougherty, Amber L. Dye, Judy Hollingsworth-Fridlund, Peggy Fortlage, Dale Coimbra, Raul TI Combat Versus Civilian Open Tibia Fractures: The Effect of Blast Mechanism on Limb Salvage SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Combat injury; Combat casualty; Wounds; Military; Open fracture; Tibia fracture; MESS ID OPERATION-IRAQI-FREEDOM; EXTREMITY SEVERITY SCORE; EARLY AMPUTATION; TRAUMA; INJURIES AB Background: This study compares open tibia fractures in US Navy and US Marine Corps casualties from the current conflicts with those from a civilian Level I trauma center to analyze the effect of blast mechanism on limb-salvage rates. Methods: Data from the 28,646 records in the University of California San Diego Trauma Registry from 1985 to 2006 was compared with 2,282 records from the US Navy and US Marine Corps Combat Trauma Registry Expeditionary Medical Encounter Database for the period of March 2004 to August 2007. Injuries were categorized by Gustilo-Anderson (G-A) open fracture classification. Independent variables included age, gender, mechanism of injury including blast mechanisms, shock, blood loss, prehospital time, procedures, Injury Severity Score, length of stay, and Mangled Extremity Severity Score (MESS). Dependent variables included early or late amputation and mortality. Results: The civilian group had 850 open tibia fractures with 45 amputations; the military group had 21 amputation patients (3 bilateral) in 115 open tibia fractures. Military group patients were more severely injured, more likely have hypotension, and had a higher amputation rate for G-A IIIB and IIIC fractures then civilian group patients. Blast mechanism was seen in the majority of military group patients and was rare in the civilian group. MESS scores had poor sensitivity (0.46, 95% confidence interval: 0.29-0.64) in predicting the need for amputation in the civilian group; in the military group sensitivity was better (0.67, 95% confidence interval: 0.43-0.85), but successful limb salvage was still possible in most cases with an MESS score of >= 7 when attempted. Conclusion: Despite current therapy, limb salvage for G-A IIIB and IIIC grades are significantly worse for open tibia fractures as a result of blast injury when compared with typical civilian mechanisms. MESS scores do not adequately predict likelihood of limb salvage in combat or civilian open tibia fractures. C1 [Doucet, Jay J.] Univ Calif San Diego, Med Ctr, Div Trauma Burns & Surg Crit Care, San Diego, CA 92103 USA. [Galarneau, Michael R.; Dye, Judy] USN, Hlth Res Ctr, San Diego, CA 92152 USA. RP Doucet, JJ (reprint author), Univ Calif San Diego, Med Ctr, Div Trauma Burns & Surg Crit Care, 200 W Arbor Dr, San Diego, CA 92103 USA. EM jdoucet@ucsd.edu FU Office of Naval Research, Arlington, VA [60332] FX Department of Defense support for this project was provided by the Office of Naval Research, Arlington, VA 22203 under work unit 60332. NR 18 TC 21 Z9 26 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD MAY PY 2011 VL 70 IS 5 BP 1241 EP 1247 DI 10.1097/TA.0b013e3182095b52 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 762LQ UT WOS:000290480300053 PM 21610438 ER PT J AU Stemper, BD Tang, SJ Yoganandan, N Shender, BS Rao, RD AF Stemper, Brian D. Tang, Shu J. Yoganandan, Narayan Shender, Barry S. Rao, Raj D. TI Upright magnetic resonance imaging measurement of prevertebral soft tissue in the cervical spine of normal volunteers SO SPINE JOURNAL LA English DT Article DE Prevertebral soft-tissue width; Magnetic resonance imaging; Radiographs; Upright ID NECK; RADIOGRAPHS; THICKNESS; INJURY; FUSION; TRAUMA AB BACKGROUND CONTEXT: Anteroposterior width of prevertebral soft tissues (PVSTs) in the cervical spine has long been considered a valuable radiographic measurement for evaluation of occult cervical spine pathology. These measurements, generally obtained from lateral radiographs of the cervical spine, have been used clinically as references for the evaluation of patients with traumatic, neoplastic, or other cervical spine disorders. Magnetic resonance imaging (MRI) offers a subtle delineation of the soft-tissue structures anterior to the vertebral column, with the potential for more accurate and sensitive determination of PVST width. Upright magnetic resonance images permit comparison with and validation of previously reported upright lateral radiographic measurements of PVST width. To our knowledge, evaluation of cervical spine PVST width using upright MRI has not been previously published in the English literature. PURPOSE: The purposes of this study were to validate lateral radiographic measurements of PVST width using upright weight-bearing MRI in healthy subjects and quantify effects of spinal level and gender. STUDY DESIGN: Clinical study in asymptomatic volunteers. METHODS: Eleven male and eight female volunteers consented and were enrolled in the study. All volunteers were asymptomatic and had no history of cervical spine injury or degenerative disease. Prevertebral soft-tissue width was measured at each cervical level from C2 to C7 using upright weight-bearing MRI. Statistically significant differences in PVST width based on spinal level and gender were determined using two-factor analysis of variance. RESULTS: Width magnitudes were significantly dependent on gender (p<.0001) and spinal level (p<.0001). All C3 and C6 measurements were below the traditionally accepted values of 7 and 20 mm, respectively, that would be considered "abnormal." Prevertebral soft-tissue width was greater in men at upper and lower extents of the cervical spine. Prevertebral soft-tissue widths reported in the present study were similar in magnitude and level-by-level trends to measurements of asymptomatic volunteers obtained using lateral radiography. CONCLUSION: The present study validated the use of lateral radiography to measure PVST width, presented level-by-level and gender-specific normative data, and provided a weighted statistical analysis of differences between normal volunteers and injured patients. (C) 2011 Elsevier Inc. All rights reserved. C1 [Tang, Shu J.; Rao, Raj D.] Med Coll Wisconsin, Dept Orthopaed Surg, Milwaukee, WI 53226 USA. [Stemper, Brian D.; Yoganandan, Narayan; Rao, Raj D.] Med Coll Wisconsin, Dept Neurosurg, Milwaukee, WI 53226 USA. [Shender, Barry S.] USN, Air Warfare Ctr, Div Aircraft, Patuxent River, MD 20670 USA. RP Rao, RD (reprint author), Med Coll Wisconsin, Dept Orthopaed Surg, 9200 W Wisconsin Ave, Milwaukee, WI 53226 USA. EM rrao@mcw.edu FU United States Department of Defense-Navy; United Stated Department of Defense-Army Medical Research Acquisition; National Highway Traffic Safety Administration; Office of Naval Research through Naval Air Warfare Center Aircraft Division [N00421-10-C-0049]; Department of Veterans Affairs Medical Research FX Author disclosures: BDS: Nothing to disclose. SJT: Nothing to disclose. NY: Nothing to disclose. BSS: Nothing to disclose. RDR: Board of Directors: North American Spine Society (nonfinancial); Scientific Advisory Board: US Food and Drug Administration Scientific Advisory Panel on Orthopaedic and Rehabilitation Devices (A); Grants: United States Department of Defense-Navy (G, Paid directly to institution/employer), United Stated Department of Defense-Army Medical Research Acquisition (F, Paid directly to institution/employer); National Highway Traffic Safety Administration (F, Paid directly to institution/employer); Other: The Spine Journal (nonfinancial), Seminars in Spine Surgery (A).; This research was supported in part by the Office of Naval Research through Naval Air Warfare Center Aircraft Division Contract (N00421-10-C-0049) and the Department of Veterans Affairs Medical Research. NR 16 TC 1 Z9 1 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1529-9430 J9 SPINE J JI Spine Journal PD MAY PY 2011 VL 11 IS 5 BP 412 EP 415 DI 10.1016/j.spinee.2011.04.002 PG 4 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 761KN UT WOS:000290396800009 PM 21558035 ER PT J AU Sandweiss, DA Slymen, DJ LeardMann, CA Smith, B White, MR Boyko, EJ Hooper, TI Gackstetter, GD Amoroso, PJ Smith, TC AF Sandweiss, Donald A. Slymen, Donald J. LeardMann, Cynthia A. Smith, Besa White, Martin R. Boyko, Edward J. Hooper, Tomoko I. Gackstetter, Gary D. Amoroso, Paul J. Smith, Tyler C. CA Millennium Cohort Study Team TI Preinjury Psychiatric Status, Injury Severity, and Postdeployment Posttraumatic Stress Disorder SO ARCHIVES OF GENERAL PSYCHIATRY LA English DT Article ID MOTOR-VEHICLE ACCIDENTS; READJUSTMENT RATING-SCALE; COMBAT TRAUMA REGISTRY; MENTAL-HEALTH PROBLEMS; MILLENNIUM COHORT; PRIMARY-CARE; MILITARY SERVICE; RISK-FACTORS; US MILITARY; PERCEIVED THREAT AB Context: Physical injury has been associated with the development of posttraumatic stress disorder (PTSD). Previous studies have retrospectively examined the relationship of preinjury psychiatric status and postinjury PTSD with conflicting results, but no prospective studies regarding this subject have been conducted, to our knowledge. Objective: To prospectively assess the relationship of predeployment psychiatric status and injury severity with postdeployment PTSD. Design: Prospective, longitudinal study. Setting: United States military personnel deployed in support of the conflicts in Iraq and Afghanistan. Participants: United States service member participants in the Millennium Cohort Study who completed a baseline questionnaire (from July 1, 2001, through June 30, 2003) and at least 1 follow-up questionnaire (from June 1, 2004, through February 14, 2006, and from May 15, 2007, through December 31, 2008) and who were deployed in the intervening period. Self-reported health information was used to prospectively examine the relationship between baseline psychiatric status and follow-up PTSD in injured and uninjured deployed individuals. Main Outcome Measures: A positive screening result using the PTSD Checklist-Civilian Version. Results: Of 22 630 eligible participants, 1840 (8.1%) screened positive for PTSD at follow-up, and 183 (0.8%) sustained a deployment-related physical injury that was documented in the Joint Theater Trauma Registry or the Navy-Marine Corps Combat Trauma Registry Expeditionary Medical Encounter Database. The odds of screening positive for PTSD symptoms were 2.52 (95% confidence interval, 2.01-3.16) times greater in those with 1 or more defined baseline mental health disorder and 16.1% (odds ratio, 1.16; 95% confidence interval, 1.01-1.34) greater for every 3-unit increase in the Injury Severity Score. Irrespective of injury severity, self-reported preinjury psychiatric status was significantly associated with PTSD at follow-up. Conclusions: Baseline psychiatric status and deployment-related physical injuries were associated with screening positive for postdeployment PTSD. More vulnerable members of the deployed population might be identified and benefit from interventions targeted to prevent or to ensure early identification and treatment of postdeployment PTSD. C1 [Sandweiss, Donald A.; LeardMann, Cynthia A.; Smith, Besa; White, Martin R.; Smith, Tyler C.] USN, Hlth Res Ctr, Dept Deployment Hlth Res, San Diego, CA 92106 USA. [Slymen, Donald J.] San Diego State Univ, Grad Sch Publ Hlth, San Diego, CA 92182 USA. [Boyko, Edward J.] Vet Affairs Puget Sound Hlth Care Syst, Seattle Epidemiol Res & Informat Ctr, Seattle, WA USA. [Hooper, Tomoko I.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Gackstetter, Gary D.] Analyt Serv Inc, Arlington, VA USA. [Amoroso, Paul J.] Madigan Army Med Ctr, Dept Clin Invest, Tacoma, WA 98431 USA. RP LeardMann, CA (reprint author), USN, Hlth Res Ctr, Dept Deployment Hlth Res, 140 Sylvester Rd, San Diego, CA 92106 USA. EM cynthia.leardmann@med.navy.mil FU US Department of Defense; Veterans Affairs Puget Sound Health Care System FX This work represents report 10-03, supported by the US Department of Defense, within work unit 60002. The work of Dr Boyko in this project was supported by the Veterans Affairs Puget Sound Health Care System. NR 75 TC 19 Z9 19 U1 2 U2 8 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0003-990X J9 ARCH GEN PSYCHIAT JI Arch. Gen. Psychiatry PD MAY PY 2011 VL 68 IS 5 BP 496 EP 504 PG 9 WC Psychiatry SC Psychiatry GA 757UY UT WOS:000290114500010 PM 21536979 ER PT J AU Irvine, JH Schwarzbach, S AF Irvine, James H. Schwarzbach, Sandra TI The Top 20 (Plus 5) Technologies for the World Ahead SO FUTURIST LA English DT Article C1 [Irvine, James H.] USN, Revolut Mil Affairs Program, Air Warfare Ctr, Weap Div NAWCWD, China Lake, CA USA. RP Irvine, JH (reprint author), USN, Revolut Mil Affairs Program, Air Warfare Ctr, Weap Div NAWCWD, China Lake, CA USA. EM james.irvine@navy.mil; Sandra.schwarzbach@navy.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU WORLD FUTURE SOC PI BETHESDA PA 7910 WOODMONT AVE, STE 450, BETHESDA, MD 20814 USA SN 0016-3317 J9 FUTURIST JI Futurist PD MAY-JUN PY 2011 VL 45 IS 3 BP 16 EP 24 PG 9 WC Social Issues SC Social Issues GA 747SW UT WOS:000289340900007 ER PT J AU LaMere, MW Moquin, A Lee, FEH Misra, RS Blair, PJ Haynes, L Randall, TD Lund, FE Kaminski, DA AF LaMere, Mark W. Moquin, Amy Lee, F. Eun-Hyung Misra, Ravi S. Blair, Patrick J. Haynes, Laura Randall, Troy D. Lund, Frances E. Kaminski, Denise A. TI Regulation of Antinucleoprotein IgG by Systemic Vaccination and Its Effect on Influenza Virus Clearance SO JOURNAL OF VIROLOGY LA English DT Article ID T-CELL RESPONSES; PERFORMANCE LIQUID-CHROMATOGRAPHY; A VIRUS; HETEROSUBTYPIC IMMUNITY; RECOMBINANT NUCLEOPROTEIN; PROTECTIVE IMMUNITY; PANDEMIC INFLUENZA; ANTIVIRAL IMMUNITY; ANTIBODY-RESPONSE; LETHAL INFECTION AB Seasonal influenza epidemics recur due to antigenic drift of envelope glycoprotein antigens and immune evasion of circulating viruses. Additionally, antigenic shift can lead to influenza pandemics. Thus, a universal vaccine that protects against multiple influenza virus strains could alleviate the continuing impact of this virus on human health. In mice, accelerated clearance of a new viral strain (cross-protection) can be elicited by prior infection (heterosubtypic immunity) or by immunization with the highly conserved internal nucleoprotein (NP). Both heterosubtypic immunity and NP-immune protection require antibody production. Here, we show that systemic immunization with NP readily accelerated clearance of a 2009 pandemic H1N1 influenza virus isolate in an antibody-dependent manner. However, human immunization with trivalent inactivated influenza virus vaccine (TIV) only rarely and modestly boosted existing levels of anti-NP IgG. Similar results were observed in mice, although the reaction could be enhanced with adjuvants, by adjusting the stoichiometry among NP and other vaccine components, and by increasing the interval between TIV prime and boost. Importantly, mouse heterosubtypic immunity that had waned over several months could be enhanced by injecting purified anti-NP IgG or by boosting with NP protein, correlating with a long-lived increase in anti-NP antibody titers. Thus, current immunization strategies poorly induce NP-immune antibody that is nonetheless capable of contributing to long-lived cross-protection. The high conservation of NP antigen and the known longevity of antibody responses suggest that the antiviral activity of anti-NP IgG may provide a critically needed component of a universal influenza vaccine. C1 [LaMere, Mark W.; Lee, F. Eun-Hyung; Misra, Ravi S.; Randall, Troy D.; Lund, Frances E.; Kaminski, Denise A.] Univ Rochester, Med Ctr, Dept Med, Div Allergy Immunol & Rheumatol, Rochester, NY 14642 USA. [Moquin, Amy; Haynes, Laura] Trudeau Inst, Saranac Lake, NY 12983 USA. [Blair, Patrick J.] Naval Hlth Res Ctr, Resp Dis Res Dept, San Diego, CA 92106 USA. RP Kaminski, DA (reprint author), Univ Rochester, Med Ctr, Dept Med, Div Allergy Immunol & Rheumatol, 601 Elmwood Ave, Rochester, NY 14642 USA. EM denise_kaminski@urmc.rochester.edu FU NIH [AI079537]; Department of Defense [3222]; [AI61511]; [AI72689]; [AI68056-05S1]; [HHSN2662005500029C (N01-AI50029)]; [K23 AI67501-01A1]; [N01-AI-50020]; [R24 AO054953] FX This study was funded by NIH grant AI079537 (parent and ARRA supplement) to D. A. K.; grants AI61511 and AI72689 to T. D. R.; grant AI68056-05S1 to F. E. L.; and grants HHSN2662005500029C (N01-AI50029), K23 AI67501-01A1, N01-AI-50020, and R24 AO054953 to F.E.-H.L. and by House Resolution 3222 (Department of Defense funding) to L. H. NR 59 TC 57 Z9 59 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD MAY PY 2011 VL 85 IS 10 BP 5027 EP 5035 DI 10.1128/JVI.00150-11 PG 9 WC Virology SC Virology GA 753NZ UT WOS:000289787300038 PM 21367900 ER PT J AU LeardMann, CA Kelton, ML Smith, B Littman, AJ Boyko, EJ Wells, TS Smith, TC AF LeardMann, Cynthia A. Kelton, Molly L. Smith, Besa Littman, Alyson J. Boyko, Edward J. Wells, Timothy S. Smith, Tyler C. CA Millennium Cohort Study Team TI Prospectively Assessed Posttraumatic Stress Disorder and Associated Physical Activity SO PUBLIC HEALTH REPORTS LA English DT Article ID MENTAL-HEALTH PROBLEMS; MILLENNIUM COHORT; US MILITARY; MEDICAL OUTCOMES; WAR VETERANS; SELF-REPORTS; IRAQ WAR; SYMPTOMS; EXERCISE; DEPRESSION AB Objectives. We examined the association of physical activity with prospectively assessed posttraumatic stress disorder (PTSD) symptoms in a military cohort. Methods. Using baseline and follow-up questionnaire data from a large prospective study of U.S. service members, we applied multivariable logistic regression to examine the adjusted odds of new-onset and persistent PTSD symptoms associated with light/moderate physical activity, vigorous physical activity, and strength training at follow-up. Results. Of the 38,883 participants, 89.4% reported engaging in at least 30 minutes of physical activity per week. At follow-up, those who reported proportionately less physical activity were more likely to screen positive for PTSD. Vigorous physical activity had the most consistent relationship with PTSD. Those who reported at least 20 minutes of vigorous physical activity twice weekly had significantly decreased odds for new-onset (odds ratio (OR] = 0.58, 95% confidence interval [CI] 0.49, 0.70) and persistent (OR=0.59, 95% CI 0.42, 0.83) PTSD symptoms. Conclusions. Engagement in physical activity, especially vigorous activity, is significantly associated with decreased odds of PTSD symptoms among U.S. service members. While further longitudinal research is necessary, a physical activity component may be valuable to PTSD treatment and prevention programs. C1 [LeardMann, Cynthia A.; Kelton, Molly L.; Smith, Besa; Wells, Timothy S.; Smith, Tyler C.] USN, Hlth Res Ctr, Dept Def Ctr Deployment Hlth Res, San Diego, CA 92106 USA. [Littman, Alyson J.; Boyko, Edward J.] Dept Vet Affairs Puget Sound Hlth Care Syst, Seattle, WA USA. [Littman, Alyson J.; Boyko, Edward J.] Univ Washington, Seattle Epidemiol Res & Informat Ctr, Seattle, WA 98195 USA. RP LeardMann, CA (reprint author), USN, Hlth Res Ctr, Dept Def Ctr Deployment Hlth Res, 140 Sylvester Rd, San Diego, CA 92106 USA. EM cynthia.leardmann@med.navy.mil FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland; U.S. Department of Defense [60002]; Department of Veterans Affairs (VA); VA Pugent Sound FX The authors thank Scott L. Seggerman from the Management Information Division, U.S. Defense Manpower Data Center, Seaside, California; Michelle LeWark from NHRC; and all the professionals from the U.S. Army Medical Research and Materiel Command, especially, those from the Military Operational Medicine Research Program, Fort Detrick, Maryland. Finally, the authors appreciate the support of the Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland.; This study represents NHRC report 09-07, supported by the U.S. Department of Defense, under work unit. no. 60002. This article is based upon work supported in part by the Office of Research and Development Cooperative Studies Program, Department of Veterans Affairs (VA). VA Pugent Sound provided support for Drs. Littman's and Boyko's participation in his research. NR 57 TC 10 Z9 10 U1 2 U2 22 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1900 M ST NW, STE 710, WASHINGTON, DC 20036 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD MAY-JUN PY 2011 VL 126 IS 3 BP 371 EP 383 PG 13 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 752AJ UT WOS:000289659600011 PM 21553666 ER PT J AU Macera, CA Aralis, HJ Rauh, MJ MacGregor, A AF Macera, Caroline A. Aralis, Hilary J. Rauh, Mitchell J. MacGregor, Andrew TI Postdeployment Symptom Reporting for Blast-Related Traumatic Brain Injury and/or Posttraumatic Stress Syndrome SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Macera, Caroline A.; Aralis, Hilary J.; Rauh, Mitchell J.; MacGregor, Andrew] Naval Hlth Res Ctr, San Diego, CA USA. EM cmacera@mail.sdsu.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2011 VL 43 IS 5 SU 1 MA 1578 BP 355 EP 355 PG 1 WC Sport Sciences SC Sport Sciences GA V34IG UT WOS:000209079501334 ER PT J AU Kelly, K Blaszczak, A Haus, JM Patrick-Melin, A Fealy, C Solomon, TPJ Kalinski, MI Kirwan, JP AF Kelly, Karen Blaszczak, Alecia Haus, Jacob M. Patrick-Melin, Aimee Fealy, Ciaran Solomon, Thomas P. J. Kalinski, Michael I. Kirwan, John P. TI 7-Days of Aerobic Exercise Increases High Molecular Weight Adiponectin and Improves Fat Oxidation in Obese Adults SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Kelly, Karen] Naval Hlth Res Ctr, San Diego, CA USA. [Blaszczak, Alecia] Case Western Reserve Univ, Cleveland, OH 44106 USA. [Haus, Jacob M.; Fealy, Ciaran; Solomon, Thomas P. J.; Kirwan, John P.] Cleveland Clin, Lerner Res Inst, Cleveland, OH 44106 USA. [Patrick-Melin, Aimee; Kalinski, Michael I.] Kent State Univ, Kent, OH 44242 USA. EM karen.kelly@med.navy.mil NR 0 TC 0 Z9 0 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2011 VL 43 IS 5 SU 1 MA 2738 BP 766 EP 766 PG 1 WC Sport Sciences SC Sport Sciences GA V34IG UT WOS:000209079503207 ER PT J AU Houng, HSH Zhou, YF Lyons, A Solovyov, A Street, C Firth, C Lipkin, WI Myers, C Blair, P Kuschner, R AF Houng, Huo-Shu H. Zhou, Yanfei Lyons, Arthur Solovyov, Alexander Street, Craig Firth, Cadhla Lipkin, W. I. Myers, Chris Blair, Patrick Kuschner, Robert TI Evolutionary studies of 2009 H1N1 pandemic via next generation sequencing (NGS): circulating influenza A from the worldwide locations are the variants of original 2009 H1N1 SO INFLUENZA AND OTHER RESPIRATORY VIRUSES LA English DT Article; Proceedings Paper CT Conference on Options for the Control of Influenza VII CY SEP 03-07, 2010 CL Hong Kong, PEOPLES R CHINA DE 2009 H1N1; evolution; next generation sequencing ID VIRUS; TRANSMISSION; CULTURE AB Pandemic 2009 influenza A virus (A/H1N1/2009) continues to cause worldwide influenza outbreaks beyond its 1st anniversary. Full genomic sequence analysis of 2009 pandemic infections might provide an important role on preparation for future influenza outbreaks. We investigated the potential of ultra-deep pyrosequencing (Roche 454 FLX) to determine and assemble >100 full genome sequences of novel 2009 H1N1 viruses isolated worldwide since the beginning of the 2009 pandemic. Phylogenetic studies of the eight influenza A gene segments were generated and were found to display higher genetic diversity for HA and NA segments as compared to the mutational rates for other five RNA segments. Analysis of full influenza genomes containing all 8 concatenated RNA segments revealed the existence of two distinctive genetic groups, Clades 1 and 2. It was concluded that 2009 H1N1 influenza A currently causing large scale global infections all belong to the genetic Clade 2. The initial 2009 H1N1 isolates of Mexican/California origins isolated at the beginning of 2009 pandemics are probably no longer in circulation. C1 [Houng, Huo-Shu H.; Zhou, Yanfei; Lyons, Arthur; Kuschner, Robert] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Washington, DC 20307 USA. [Solovyov, Alexander; Street, Craig; Firth, Cadhla; Lipkin, W. I.] Columbia Univ, Ctr Infect & Immun, New York, NY USA. [Myers, Chris; Blair, Patrick] USN, Hlth Res Ctr, San Diego, CA 92152 USA. RP Houng, HSH (reprint author), Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Washington, DC 20307 USA. RI Lyons, Arthur/B-8923-2011; Valle, Ruben/A-7512-2013 NR 23 TC 0 Z9 0 U1 2 U2 8 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1750-2640 J9 INFLUENZA OTHER RESP JI Influenza Other Respir. Viruses PD MAY PY 2011 VL 5 SU 1 BP 398 EP 402 PG 5 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA 747BV UT WOS:000289296200130 ER PT J AU Crum-Cianflone, NF Iverson, E Defang, G Blair, PJ Eberly, LE Maguire, J Ganesan, A Faix, D Duplessis, C Lalani, T Whitman, T Brandt, C Macalino, G Millar, EV Burgess, T AF Crum-Cianflone, Nancy F. Iverson, Erik Defang, Gabriel Blair, Patrick J. Eberly, Lynn E. Maguire, Jason Ganesan, Anuradha Faix, Dennis Duplessis, Christopher Lalani, Tahaniyat Whitman, Timothy Brandt, Carolyn Macalino, Grace Millar, Eugene V. Burgess, Timothy TI Durability of antibody responses after receipt of the monovalent 2009 pandemic influenza A (H1N1) vaccine among HIV-infected and HIV-uninfected adults SO VACCINE LA English DT Article DE Influenza; Pandemic 2009 H1N1; Vaccine responses; HIV; Durability; Long-term immunity ID ACTIVE ANTIRETROVIRAL THERAPY; HIV-1-INFECTED PATIENTS; INACTIVATED INFLUENZA; DOUBLE-BLIND; VIRUS-VACCINES; IMMUNOGENICITY; EFFICACY; TRIAL; IMMUNIZATION; INDIVIDUALS AB Background: Human immunodeficiency virus (HIV)-infected persons are at risk for severe influenza infections. Although vaccination against the H1N1 pandemic influenza strain is recommended, currently there are no data on the durability of post-vaccination antibody responses in this population. Methods: HIV-infected and HIV-uninfected adults (18-50 years old) received a single dose of monovalent 2009 influenza A (H1N1) vaccine (strain A/California/7/2009H1N1). Antibody levels to the 2009 H1N1 pandemic strain were determined at day 0, day 28, and 6 months by hemagglutination-inhibition assay. A seroprotective response was a post-vaccination titer of >= 1:40 among those with a pre-vaccination level of <= 1:10. Geometric mean titers (GMT) and factors associated with higher levels were also evaluated. Results: We studied 127 participants with a median age of 35 (interquartile range (IQR) 28, 42) years. Among the HIV-infected arm (n = 63), the median CD4 count was 595 (IQR 476, 819) cells/mm(3) and 83% were receiving HAART. Thirty-five percent of all participants had a pre-vaccination level of > 1:10. HIV-infected compared to HIV-uninfected adults were less likely to generate a seroprotective response at day 28(54% vs. 75%, adjusted OR 0.23, p = 0.021) or have a durable response at 6 months post-vaccination (28% vs. 56%, adjusted OR 0.19, p = 0.005). Additionally, although pre-vaccination GMT were similar in both arms (median 7 vs. 8, p = 0.11), the GMT at 6 months was significantly lower among HIV-infected versus HIV-uninfected adults (median 20 vs. 113, p = 0.003). Among HIV-infected persons, younger age (p = 0.035) and receipt of HAART (p = 0.028) were associated with higher GMTs at 6 months. Conclusions: Despite vaccination, most HIV-infected adults do not generate durable seroprotective antibody responses to the 2009 influenza A (H1N1) virus, and hence may remain vulnerable to infection. In addition to HAART use, more immunogenic vaccines are likely needed for improving protection against influenza in this population. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Crum-Cianflone, Nancy F.] USN, San Diego Med Ctr, Clin Invest Dept KCA, Infect Dis Clin, San Diego, CA 92134 USA. [Crum-Cianflone, Nancy F.; Iverson, Erik; Eberly, Lynn E.; Maguire, Jason; Ganesan, Anuradha; Lalani, Tahaniyat; Whitman, Timothy; Brandt, Carolyn; Macalino, Grace; Millar, Eugene V.; Burgess, Timothy] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Iverson, Erik; Eberly, Lynn E.] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Defang, Gabriel; Burgess, Timothy] USN, Med Res Ctr, Silver Spring, MD USA. [Blair, Patrick J.; Faix, Dennis] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Infect Dis Clin, Bethesda, MD USA. RP Crum-Cianflone, NF (reprint author), USN, San Diego Med Ctr, Clin Invest Dept KCA, Infect Dis Clin, 34800 Bob Wilson Dr,Ste 5, San Diego, CA 92134 USA. EM nancy.crum@med.navy.mil RI Valle, Ruben/A-7512-2013; OI Eberly, Lynn/0000-0003-4763-330X FU Infectious Disease Clinical Research Program (IDCRP) [IDCRP-053]; Department of Defense (DoD) through the Uniformed Services University of the Health Sciences.; National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) [Y1-AI-5072]; Armed Forces Health Surveillance Center [I204_10] FX Support for this work (IDCRP-053) was provided by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072. In addition, funding was provided by the Armed Forces Health Surveillance Center's Global Emerging Infections Surveillance and Response System via project I204_10. The content of this publication is the sole responsibility of the authors and does not necessarily reflect the views or policies of the NIH or the Department of Health and Human Services, the DoD or the Departments of the Army. Navy or Air Force. Mention of trade names, commercial products, or organizations does not imply endorsement by the U.S. Government. NR 49 TC 24 Z9 24 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD APR 12 PY 2011 VL 29 IS 17 BP 3183 EP 3191 DI 10.1016/j.vaccine.2011.02.040 PG 9 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 764BJ UT WOS:000290603100016 PM 21371580 ER PT J AU White, MR Jacobson, IG Smith, B Wells, TS Gackstetter, GD Boyko, EJ Smith, TC AF White, Martin R. Jacobson, Isabel G. Smith, Besa Wells, Timothy S. Gackstetter, Gary D. Boyko, Edward J. Smith, Tyler C. CA Millennium Cohort Study Team TI Health care utilization among complementary and alternative medicine users in a large military cohort SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE LA English DT Article ID UNITED-STATES; MILLENNIUM COHORT; DRUG-INTERACTIONS; PREVALENCE; THERAPIES; SELECTION; SYMPTOMS; PATTERNS; SCORES; TRENDS AB Background: Complementary and Alternative Medicine use and how it impacts health care utilization in the United States Military is not well documented. Using data from the Millennium Cohort Study we describe the characteristics of CAM users in a large military population and document their health care needs over a 12-month period. The aim of this study was to determine if CAM users are requiring more physician-based medical services than users of conventional medicine. Methods: Inpatient and outpatient medical services were documented over a 12-month period for 44,287 participants from the Millennium Cohort Study. Equal access to medical services was available to anyone needing medical care during this study period. The number and types of medical visits were compared between CAM and non-CAM users. Chi square test and multivariable logistic regression was applied for the analysis. Results: Of the 44,287 participants, 39% reported using at least one CAM therapy, and 61% reported not using any CAM therapies. Those individuals reporting CAM use accounted for 45.1% of outpatient care and 44.8% of inpatient care. Individuals reporting one or more health conditions were 15% more likely to report CAM use than non-CAM users and 19% more likely to report CAM use if reporting one or more health symptoms compared to non-CAM users. The unadjusted odds ratio for hospitalizations in CAM users compared to non-CAM users was 1.29 (95% CI: 1.16-1.43). The mean number of days receiving outpatient care for CAM users was 7.0 days and 5.9 days for non-CAM users (p < 0.001). Conclusions: Our study found those who report CAM use were requiring more physician-based medical services than users of conventional medicine. This appears to be primarily the result of an increase in the number of health conditions and symptoms reported by CAM users. C1 [White, Martin R.; Jacobson, Isabel G.; Smith, Besa; Wells, Timothy S.; Smith, Tyler C.] USN, Dept Def Ctr Deployment Hlth Res, Hlth Res Ctr, San Diego, CA 92152 USA. [Gackstetter, Gary D.] Analyt Serv Inc ANSER, Arlington, VA USA. [Boyko, Edward J.] Vet Affairs Puget Sound Hlth Care Syst, Seattle Epidemiol Res & Informat Ctr, Seattle, WA USA. RP White, MR (reprint author), USN, Dept Def Ctr Deployment Hlth Res, Hlth Res Ctr, San Diego, CA 92152 USA. EM martin.white@med.navy.mil FU Department of Veterans Affairs; Henry M. Jackson Foundation FX We appreciate the support of the Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, MD.; The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of the Army, Department of the Air Force, Department of Defense, or the US Government. The Department of Veterans Affairs supported Dr. Boyko's involvement in this research. This research has been conducted in compliance with all applicable federal regulations governing the protection of human subjects in research (protocol NHRC.2000.0007). NR 39 TC 14 Z9 14 U1 1 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1472-6882 J9 BMC COMPLEM ALTERN M JI BMC Complement. Altern. Med. PD APR 11 PY 2011 VL 11 AR 27 DI 10.1186/1472-6882-11-27 PG 11 WC Integrative & Complementary Medicine SC Integrative & Complementary Medicine GA 755SF UT WOS:000289956000001 PM 21481260 ER PT J AU Guandalini, GS Zhang, L Fornero, E Centeno, JA Mokashi, VP Ortiz, PA Stockelman, MD Osterburg, AR Chapman, GG AF Guandalini, Gustavo S. Zhang, Lingsu Fornero, Elisa Centeno, Jose A. Mokashi, Vishwesh P. Ortiz, Pedro A. Stockelman, Michael D. Osterburg, Andrew R. Chapman, Gail G. TI Tissue Distribution of Tungsten in Mice Following Oral Exposure to Sodium Tungstate SO CHEMICAL RESEARCH IN TOXICOLOGY LA English DT Article ID DIABETIC-RATS; NORMALIZATION; CELLS AB Heavy metal tungsten alloys have replaced lead and depleted uranium in many munitions applications, due to public perception of these elements as environmentally unsafe. Tungsten materials left in the environment may become bioaccessible as tungstate, which might lead to population exposure through water and soil contamination. Although tungsten had been considered a relatively inert and toxicologically safe material, recent research findings have raised concerns about possible deleterious health effects after acute and chronic exposure to this metal. This investigation describes tissue distribution of tungsten in mice following oral exposure to sodium tungstate. Twenty-four 6-9 weeks-old C57BL/6 laboratory mice were exposed to different oral doses of sodium tungstate (0, 62.5, 125, and 200 mg/kg/d) for 28 days, and after one day, six organs were harvested for trace element analysis with inductively coupled plasma mass spectrometry (ICP-MS). Kidney, liver, colon, bone, brain, and spleen were analyzed by sector-field high-resolution ICP-MS. The results showed increasing tungsten levels in all organs with increased dose of exposure, with the highest concentration found in the bones and the lowest concentration found in brain tissue. Gender differences were noticed only in the spleen (higher concentration of tungsten in female animals), and increasing tungsten levels in this organ were correlated with increased iron levels, something that was not observed for any other organ or either of the two other metals analyzed (nickel and cobalt). These findings confirmed most of what has been published on tungsten tissue distribution; they also showed that the brain is relatively protected from oral exposure. Further studies are necessary to clarify the findings in splenic tissue, focusing on possible immunological effects of tungsten exposure. C1 [Guandalini, Gustavo S.; Zhang, Lingsu; Fornero, Elisa; Centeno, Jose A.] Armed Forces Inst Pathol, Dept Environm & Infect Dis Sci, Div Biophys Toxicol, Washington, DC 20306 USA. [Mokashi, Vishwesh P.; Ortiz, Pedro A.; Stockelman, Michael D.] USN, Hlth Res Ctr Detachment, Environm Hlth Effects Lab, Wright Patterson AFB, OH USA. [Osterburg, Andrew R.] Shriners Hosp Children, Cincinnati, OH USA. [Chapman, Gail G.] USA, Med Res & Mat Command, Mil Infect Dis Res Program, Ft Detrick, MD USA. RP Centeno, JA (reprint author), Armed Forces Inst Pathol, Dept Environm & Infect Dis Sci, Div Biophys Toxicol, Washington, DC 20306 USA. EM jose.a.centeno@us.army.mil FU Office of Naval Research work unit [60862]; Naval Health Research Center Detachment - Environmental Health Effects Laboratory [N4181709MP9T018] FX This work has been funded by a grant from the Office of Naval Research work unit 60862 and by an Interservice Support Agreement (ISSA) from the Naval Health Research Center Detachment - Environmental Health Effects Laboratory (N4181709MP9T018). NR 24 TC 22 Z9 22 U1 0 U2 9 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0893-228X EI 1520-5010 J9 CHEM RES TOXICOL JI Chem. Res. Toxicol. PD APR PY 2011 VL 24 IS 4 BP 488 EP 493 DI 10.1021/tx200011k PG 6 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology SC Pharmacology & Pharmacy; Chemistry; Toxicology GA 749WB UT WOS:000289500800008 PM 21375269 ER PT J AU Mullen, L Alley, D Cochenour, B AF Mullen, Linda Alley, Derek Cochenour, Brandon TI Investigation of the effect of scattering agent and scattering albedo on modulated light propagation in water SO APPLIED OPTICS LA English DT Article ID POLARIZATION; MULTIPLE AB A recent paper described experiments completed to study the effect of scattering on the propagation of modulated light in laboratory tank water [Appl. Opt. 48, 2607 (2009)]. Those measurements were limited to a specific scattering agent (Maalox antacid) with a fixed scattering albedo (0.95). The purpose of this paper is to study the effects of different scattering agents and scattering albedos on modulated light propagation in water. The results show that the scattering albedo affects the number of attenuation lengths that the modulated optical signal propagates without distortion, while the type of scattering agent affects the degree to which the modulation is distorted with increasing attenuation length. C1 [Mullen, Linda; Alley, Derek; Cochenour, Brandon] NAVAIR, Naval Air Syst Command, Elect Opt & Special Mission Sensors Div, Patuxent River, MD 20670 USA. RP Mullen, L (reprint author), NAVAIR, Naval Air Syst Command, Elect Opt & Special Mission Sensors Div, 22347 Cedar Point Rd, Patuxent River, MD 20670 USA. EM linda.mullen@navy.mil FU In-House Laboratory Innovative Research (ILIR) FX This work was funded by In-House Laboratory Innovative Research (ILIR) funds. The authors thank Dr. Yogesh Agrawal of Sequoia Scientific, Inc. for providing the volume scattering function measurements and Dr. Fraser Dalgleish of the Harbor Branch Oceanographic Institute at Florida Atlantic University for providing the photographs of the Mg(OH)2 and Al(OH)3 scattering agents. NR 9 TC 19 Z9 20 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD APR 1 PY 2011 VL 50 IS 10 BP 1396 EP 1404 DI 10.1364/AO.50.001396 PG 9 WC Optics SC Optics GA 744CF UT WOS:000289070300017 PM 21460906 ER PT J AU Hahn, BP Long, JW Mansour, AN Pettigrew, KA Osofsky, MS Rolison, DR AF Hahn, Benjamin P. Long, Jeffrey W. Mansour, Azzam N. Pettigrew, Katherine A. Osofsky, Michael S. Rolison, Debra R. TI Electrochemical Li-ion storage in defect spinel iron oxides: the critical role of cation vacancies SO ENERGY & ENVIRONMENTAL SCIENCE LA English DT Article ID RAY PHOTOELECTRON-SPECTROSCOPY; LITHIUM INSERTION; HEMATITE TRANSFORMATION; MOLYBDENUM OXIDE; THIN-FILMS; PHASE; NANOCRYSTALLINE; GAMMA-FE2O3; BATTERIES; PARTICLES AB Rechargeable lithium-ion batteries are the preferred power source for consumer electronic devices, but the cost and toxicity of many cathode materials limit their scale-up. Worldwide research efforts are addressing this concern by transitioning from conventional Co- and Ni-based intercalation hosts towards Fe-and Mn-based alternatives. The unfavorable energetics of the Fe2+/3+ redox couple and limited Li-insertion capacities render the use of iron oxides impractical. We address this limitation with the defect spinel ferrite gamma-Fe2O3 as a model structure for Li-ion insertion by replacing a fraction of the Fe3+ sites with highly oxidized Mo6+ to generate cation vacancies that shift the onset of Li-ion insertion to more positive potentials as well as increase capacity. In the present study, native and Mo-substituted iron oxides are synthesized via base-catalyzed precipitation in aqueous media, yielding nanocrystalline spinel materials that also exhibit short-range disorder characteristic of a proton-stabilized structure. The Mo-substituted ferrite reported herein is estimated to have similar to 3x as many cation vacancies as gamma-Fe2O3 with a corresponding increase in the Li-ion capacity to >100 mA h g(-1) between 4.1 and 2.0 V vs. Li/Li+. This dual enhancement in capacity and insertion potential will enable these and related defect spinel ferrites to be explored as positive electrode materials for lithium batteries, while retaining the cost advantages of a material whose metal composition is still predominately iron based. C1 [Hahn, Benjamin P.; Long, Jeffrey W.; Pettigrew, Katherine A.; Rolison, Debra R.] USN, Res Lab, Surface Chem Branch, Washington, DC 20375 USA. [Mansour, Azzam N.] Syst & Mat Power & Protect Branch, Naval Surface Warfare Ctr, Carderock Div, Bethesda, MD 20817 USA. [Pettigrew, Katherine A.] Nova Res Inc, Alexandria, VA 22308 USA. [Osofsky, Michael S.] USN, Res Lab, Mat & Sensors Branch, Washington, DC 20375 USA. RP Hahn, BP (reprint author), USN, Res Lab, Surface Chem Branch, Code 6170, Washington, DC 20375 USA. EM jeffrey.long@nrl.navy.mil; rolison@nrl.navy.mil RI Dom, Rekha/B-7113-2012 FU U.S. Department of Energy, Office of Basic Energy Sciences [DE-AC02-98CH10886]; Office of Naval Research; Carderock Division of the Naval Surface Warfare Center's In-house Laboratory FX The authors would like to thank Dr James Zaykoski (Naval Surface Warfare Center, Carderock Division, West Bethesda, MD) for running the PXRD measurements. We especially acknowledge Prof. Stephanie Brock (Wayne State University) for useful discussions. B. P. H. is an NRL-National Research Council Postdoctoral Associate (2009-2011). A.N.M. acknowledges support by the Carderock Division of the Naval Surface Warfare Center's In-house Laboratory Independent Research Program administrated under the Office of Naval Research's Program Element 0601152N. Funding for this work was provided by the Office of Naval Research. The XAS experiments were conducted at the National Synchrotron Light Source of Brookhaven National Laboratory, which is supported by the U.S. Department of Energy, Office of Basic Energy Sciences under contract No. DE-AC02-98CH10886. NR 50 TC 24 Z9 24 U1 9 U2 72 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1754-5692 EI 1754-5706 J9 ENERG ENVIRON SCI JI Energy Environ. Sci. PD APR PY 2011 VL 4 IS 4 BP 1495 EP 1502 DI 10.1039/c0ee00819b PG 8 WC Chemistry, Multidisciplinary; Energy & Fuels; Engineering, Chemical; Environmental Sciences SC Chemistry; Energy & Fuels; Engineering; Environmental Sciences & Ecology GA 743EV UT WOS:000289001400048 ER PT J AU Carney, JR Lightstone, JM Piecuch, S Koch, JD AF Carney, J. R. Lightstone, J. M. Piecuch, S. Koch, J. D. TI Water temperature and concentration measurements within the expanding blast wave of a high explosive SO MEASUREMENT SCIENCE AND TECHNOLOGY LA English DT Article DE absorption spectroscopy; water; detonation; combustion ID RESOLVED OPTICAL MEASUREMENTS; TUNABLE DIODE-LASER; SENSOR; DETONATION; COMBUSTION; PARAMETERS; ENGINES; VAPOR AB We present an application of absorption spectroscopy to directly measure temperature and concentration histories of water vapor within the expansion of a high explosive detonation. While the approach of absorption spectroscopy is well established, the combination of a fast, near-infrared array, broadband light source, and rigid gauge allow the first application of time-resolved absorption measurements in an explosive environment. The instrument is demonstrated using pentaerythritol tetranitrate with a sampling rate of 20 kHz for 20 ms following detonation. Absorption by water vapor is measured between 1335 and 1380 nm. Water temperatures are determined by fitting experimental transmission spectra to a simulated database. Water mole fractions are deduced following the temperature assignment. The sources of uncertainty and their impact on the results are discussed. These measurements will aid the development of chemical-specific reaction models and the predictive capability in technical fields including combustion and detonation science. C1 [Carney, J. R.; Lightstone, J. M.] Naval Surface Warfare Ctr, Indian Head Div, Res & Technol Div, Indian Head, MD USA. [Piecuch, S.; Koch, J. D.] Marquette Univ, Dept Engn Mech, Milwaukee, WI 53233 USA. RP Carney, JR (reprint author), Naval Surface Warfare Ctr, Indian Head Div, Res & Technol Div, Indian Head, MD USA. EM jon.koch@marquette.edu FU Defense Threat Reduction Agency FX The authors would like to thank the Defense Threat Reduction Agency for funding this work. They would also like to thank Professor Scott Sanders for thoughtful discussions and insight shared during the experiment design stage. Robert Hay also has their gratitude for assisting with the explosive testing. Lastly, the authors would like to thank Dr Thomas P McGrath II for initial detonation science simulations which have aided in some of the design work and error analysis of this gauge. Future detonation science publications comparing these experimental results to simulations are in preparation. NR 23 TC 7 Z9 7 U1 0 U2 10 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0957-0233 EI 1361-6501 J9 MEAS SCI TECHNOL JI Meas. Sci. Technol. PD APR PY 2011 VL 22 IS 4 AR 045601 DI 10.1088/0957-0233/22/4/045601 PG 10 WC Engineering, Multidisciplinary; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 735XR UT WOS:000288454500021 ER PT J AU Burke, RL Vest, KG Eick, AA Sanchez, JL Johns, MC Pavlin, JA Jarman, RG Mothershead, JL Quintana, M Palys, T Cooper, MJ Guan, J Schnabel, D Waitumbi, J Wilma, A Daniels, C Brown, ML Tobias, S Kasper, MR Williams, M Tjaden, JA Oyofo, B Styles, T Blair, PJ Hawksworth, A Montgomery, JM Razuri, H Laguna-Torres, A Schoepp, RJ Norwood, DA MacIntosh, VH Gibbons, T Gray, GC Blazes, DL Russell, KL AF Burke, Ronald L. Vest, Kelly G. Eick, Angelia A. Sanchez, Jose L. Johns, Matthew C. Pavlin, Julie A. Jarman, Richard G. Mothershead, Jerry L. Quintana, Miguel Palys, Thomas Cooper, Michael J. Guan, Jian Schnabel, David Waitumbi, John Wilma, Alisa Daniels, Candelaria Brown, Matthew L. Tobias, Steven Kasper, Matthew R. Williams, Maya Tjaden, Jeffrey A. Oyofo, Buhari Styles, Timothy Blair, Patrick J. Hawksworth, Anthony Montgomery, Joel M. Razuri, Hugo Laguna-Torres, Alberto Schoepp, Randal J. Norwood, David A. MacIntosh, Victor H. Gibbons, Thomas Gray, Gregory C. Blazes, David L. Russell, Kevin L. CA AFHSC-GEIS Influenza Surveillance TI Department of Defense influenza and other respiratory disease surveillance during the 2009 pandemic SO BMC PUBLIC HEALTH LA English DT Review ID PERSONNEL AB The Armed Forces Health Surveillance Center's Division of Global Emerging Infections Surveillance and Response System (AFHSC-GEIS) supports and oversees surveillance for emerging infectious diseases, including respiratory diseases, of importance to the U. S. Department of Defense (DoD). AFHSC-GEIS accomplishes this mission by providing funding and oversight to a global network of partners for respiratory disease surveillance. This report details the system's surveillance activities during 2009, with a focus on efforts in responding to the novel H1N1 Influenza A (A/H1N1) pandemic and contributions to global public health. Active surveillance networks established by AFHSC-GEIS partners resulted in the initial detection of novel A/H1N1 influenza in the U. S. and several other countries, and viruses isolated from these activities were used as seed strains for the 2009 pandemic influenza vaccine. Partners also provided diagnostic laboratory training and capacity building to host nations to assist with the novel A/H1N1 pandemic global response, adapted a Food and Drug Administration-approved assay for use on a ruggedized polymerase chain reaction platform for diagnosing novel A/H1N1 in remote settings, and provided estimates of seasonal vaccine effectiveness against novel A/H1N1 illness. Regular reporting of the system's worldwide surveillance findings to the global public health community enabled leaders to make informed decisions on disease mitigation measures and controls for the 2009 A/H1N1 influenza pandemic. AFHSC-GEIS's support of a global network contributes to DoD's force health protection, while supporting global public health. C1 [Burke, Ronald L.; Vest, Kelly G.; Eick, Angelia A.; Sanchez, Jose L.; Johns, Matthew C.; Blazes, David L.; Russell, Kevin L.] USAF, Hlth Surveillance Ctr, Silver Spring, MD 20910 USA. [Pavlin, Julie A.; Jarman, Richard G.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Mothershead, Jerry L.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Ctr Disaster & Humanitarian Assistance Med, Bethesda, MD 20814 USA. [Quintana, Miguel] Publ Hlth Reg S, Ft Sam Houston, TX 78234 USA. [Palys, Thomas] Landstuhl Reg Med Ctr, Dept Pathol & Area Lab Serv, CMR 402, APO, AE 09180 USA. [Cooper, Michael J.] Publ Hlth Reg Europe, CMR 402, APO, AE 09180 USA. [Guan, Jian] Publ Hlth Reg Pacific, Unit 45006, APO, AE USA. [Schnabel, David; Waitumbi, John] Attent MRU, US Embassy, Nairobi 00621, Kenya. [Wilma, Alisa; Daniels, Candelaria] US Dept Def, Vet Food Anal & Diagnost Lab, Ft Sam Houston, TX 78234 USA. [Brown, Matthew L.] USAMEDDAC Korea, Microbiol Sect, Unit 15244, APO, AP 96205 USA. [Tobias, Steven; Kasper, Matthew R.; Williams, Maya] Kompleks Pergudangan DEPKES RI, Naval Med Res Unit 2, Jakarta 10560, Indonesia. [Tjaden, Jeffrey A.; Oyofo, Buhari] Naval Med Res Unit 3, Cairo 11517, Egypt. [Styles, Timothy] USN, Environm Prevent Med Unit 2, Norfolk, VA 23511 USA. [Blair, Patrick J.; Hawksworth, Anthony] USN, Hlth Res Ctr, San Diego, CA 92106 USA. [Montgomery, Joel M.; Razuri, Hugo; Laguna-Torres, Alberto] Ctr Med Naval CMST, Naval Med Res Ctr Detachment, Lima, Peru. [Schoepp, Randal J.; Norwood, David A.] USA, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. [MacIntosh, Victor H.; Gibbons, Thomas] USAF, Sch Aerosp Med, Brooks City Base, TX 78235 USA. [Gray, Gregory C.] Univ Florida, Coll Publ Hlth & Hlth Profess, Dept Environm & Global Hlth, Gainesville, FL 32610 USA. Walter Reed Army Inst Res, Emerging Infect Dis Res Unit, Silver Spring, MD 20910 USA. Australian Army Malaria Inst, Enoggera, Qld 4051, Australia. Johns Hopkins Univ, Appl Phys Lab, Laurel, MD 20723 USA. USN, Portsmouth, VA 23708 USA. [AFHSC-GEIS Influenza Surveillance] Marine Corps Publ Hlth Ctr, Portsmouth, VA 23708 USA. Univ Buea, Lab Emerging Infect Dis, Buea, Cameroon. Global Viral Proc Initiat, San Francisco, CA 94104 USA. RP Burke, RL (reprint author), USAF, Hlth Surveillance Ctr, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Ronald.L.Burke@us.army.mil RI Razuri, Hugo/C-1542-2013; Valle, Ruben/A-7512-2013; Chiang, Vincent, Ming-Hsien/D-4312-2016; Shanks, George Dennis/F-4056-2014 OI Razuri, Hugo/0000-0003-4571-5520; Chiang, Vincent, Ming-Hsien/0000-0002-2029-7863; Shanks, George Dennis/0000-0001-5763-8660 NR 19 TC 6 Z9 7 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD MAR 4 PY 2011 VL 11 SU 2 AR S6 DI 10.1186/1471-2458-11-S2-S6 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 759WT UT WOS:000290279900006 PM 21388566 ER PT J AU Johns, MC Burke, RL Vest, KG Fukuda, M Pavlin, JA Shrestha, SK Schnabel, DC Tobias, S Tjaden, JA Montgomery, JM Faix, DJ Duffy, MR Cooper, MJ Sanchez, JL Blazes, DL AF Johns, Matthew C. Burke, Ronald L. Vest, Kelly G. Fukuda, Mark Pavlin, Julie A. Shrestha, Sanjaya K. Schnabel, David C. Tobias, Steven Tjaden, Jeffrey A. Montgomery, Joel M. Faix, Dennis J. Duffy, Mark R. Cooper, Michael J. Sanchez, Jose L. Blazes, David L. CA AFHSC-GEIS Outbreak Response TI A growing global network's role in outbreak response: AFHSC-GEIS 2008-2009 SO BMC PUBLIC HEALTH LA English DT Review ID COUNTRIES AB A cornerstone of effective disease surveillance programs comprises the early identification of infectious threats and the subsequent rapid response to prevent further spread. Effectively identifying, tracking and responding to these threats is often difficult and requires international cooperation due to the rapidity with which diseases cross national borders and spread throughout the global community as a result of travel and migration by humans and animals. From Oct. 1, 2008 to Sept. 30, 2009, the United States Department of Defense's (DoD) Armed Forces Health Surveillance Center Global Emerging Infections Surveillance and Response System (AFHSC-GEIS) identified 76 outbreaks in 53 countries. Emerging infectious disease outbreaks were identified by the global network and included a wide spectrum of support activities in collaboration with host country partners, several of which were in direct support of the World Health Organization's (WHO) International Health Regulations (IHR) (2005). The network also supported military forces around the world affected by the novel influenza A/H1N1 pandemic of 2009. With IHR (2005) as the guiding framework for action, the AFHSC-GEIS network of international partners and overseas research laboratories continues to develop into a far-reaching system for identifying, analyzing and responding to emerging disease threats. C1 [Johns, Matthew C.; Burke, Ronald L.; Vest, Kelly G.; Fukuda, Mark; Sanchez, Jose L.; Blazes, David L.] USAF, Hlth Surveillance Ctr, Silver Spring, MD 20904 USA. [Pavlin, Julie A.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Shrestha, Sanjaya K.] US Embassy, Walter Reed AFRIMS Res Unit Nepal, Kathmandu, Nepal. [Schnabel, David C.] US Embassy, Attn MRU, Nairobi 00621, Kenya. [Tobias, Steven] Kompleks Pergudangan DEPKES RI, Naval Med Res Unit 2, Jakarta 10560, Indonesia. [Tjaden, Jeffrey A.] Naval Med Res Unit 3, Cairo, Egypt. [Montgomery, Joel M.] Ctr Med Naval CMST, Naval Med Res Ctr Detachment Peru, Lima, Peru. [Faix, Dennis J.] USN, Hlth Res Ctr, San Diego, CA 92106 USA. [Duffy, Mark R.] USAF, Sch Aerosp Med, Epidemiol Consult Serv, Brooks City Base, TX 78235 USA. [Cooper, Michael J.; AFHSC-GEIS Outbreak Response] US Publ Hlth Command Provis Publ Hlth Reg Europe, Landstuhl, Germany. RP Johns, MC (reprint author), USAF, Hlth Surveillance Ctr, 11800 Tech Rd, Silver Spring, MD 20904 USA. EM Matthew.C.Johns@us.army.mil RI Valle, Ruben/A-7512-2013; Bulimo, Wallace/B-1982-2014 OI Bulimo, Wallace/0000-0001-8475-0586 NR 21 TC 2 Z9 3 U1 0 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD MAR 4 PY 2011 VL 11 SU 2 AR S3 DI 10.1186/1471-2458-11-S2-S3 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 759WT UT WOS:000290279900003 PM 21388563 ER PT J AU Meyer, WG Pavlin, JA Hospenthal, D Murray, CK Jerke, K Hawksworth, A Metzgar, D Myers, T Walsh, D Wu, M Ergas, R Chukwuma, U Tobias, S Klena, J Nakhla, I Talaat, M Maves, R Ellis, M Wortmann, G Blazes, DL Lindler, L AF Meyer, William G. Pavlin, Julie A. Hospenthal, Duane Murray, Clinton K. Jerke, Kurt Hawksworth, Anthony Metzgar, David Myers, Todd Walsh, Douglas Wu, Max Ergas, Rosa Chukwuma, Uzo Tobias, Steven Klena, John Nakhla, Isabelle Talaat, Maha Maves, Ryan Ellis, Michael Wortmann, Glenn Blazes, David L. Lindler, Luther TI Antimicrobial resistance surveillance in the AFHSC-GEIS network SO BMC PUBLIC HEALTH LA English DT Review ID SUSCEPTIBILITIES; LEPTOSPIRA AB International infectious disease surveillance has been conducted by the United States (U. S.) Department of Defense (DoD) for many years and has been consolidated within the Armed Forces Health Surveillance Center, Division of Global Emerging Infections Surveillance and Response System (AFHSC-GEIS) since 1998. This includes activities that monitor the presence of antimicrobial resistance among pathogens. AFHSC-GEIS partners work within DoD military treatment facilities and collaborate with host-nation civilian and military clinics, hospitals and university systems. The goals of these activities are to foster military force health protection and medical diplomacy. Surveillance activities include both community-acquired and health care-associated infections and have promoted the development of surveillance networks, centers of excellence and referral laboratories. Information technology applications have been utilized increasingly to aid in DoD-wide global surveillance for diseases significant to force health protection and global public health. This section documents the accomplishments and activities of the network through AFHSC-GEIS partners in 2009. C1 [Meyer, William G.; Blazes, David L.; Lindler, Luther] USAF, Hlth Surveillance Ctr, Silver Spring, MD 20904 USA. [Pavlin, Julie A.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Hospenthal, Duane] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Jerke, Kurt] Landstuhl Reg Med Ctr, Dept Immunol, CMR 402, APO, AE 09180 USA. [Hawksworth, Anthony; Metzgar, David] USN, Hlth Res Ctr, San Diego, CA 92106 USA. [Myers, Todd] Natl Naval Med Ctr, Bethesda, MD 20889 USA. [Walsh, Douglas; Wu, Max] US Embassy, US Army Med Res Unit Kenya, ATTN MRU, Nairobi 00621, Kenya. [Ergas, Rosa; Chukwuma, Uzo] USN, Portsmouth, VA 23708 USA. [Ergas, Rosa; Chukwuma, Uzo] Marine Corps Publ Hlth Ctr, Portsmouth, VA 23708 USA. [Tobias, Steven] Kompleks Pergudangan DEPKES RI, US Naval Med Res Unit 2, Jakarta 10560, Indonesia. [Klena, John; Nakhla, Isabelle; Talaat, Maha] US Naval Med Res Unit 3, Cairo 11517, Egypt. [Maves, Ryan] Ctr Med Naval CMST, US Naval Med Res Ctr Detachment, Lima, Peru. [Ellis, Michael; Wortmann, Glenn] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Meyer, WG (reprint author), USAF, Hlth Surveillance Ctr, 11800 Tech Rd, Silver Spring, MD 20904 USA. EM william.meyer6@us.army.mil RI Valle, Ruben/A-7512-2013 NR 21 TC 6 Z9 7 U1 0 U2 7 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD MAR 4 PY 2011 VL 11 SU 2 AR S8 DI 10.1186/1471-2458-11-S2-S8 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 759WT UT WOS:000290279900008 PM 21388568 ER PT J AU Otto, JL Baliga, P Sanchez, JL Johns, MC Gray, GC Grieco, J Lescano, AG Mothershead, JL Wagar, EJ Blazes, DL AF Otto, Jean L. Baliga, Priya Sanchez, Jose L. Johns, Matthew C. Gray, Gregory C. Grieco, John Lescano, Andres G. Mothershead, Jerry L. Wagar, Eric J. Blazes, David L. CA AFHSC-GEIS Training Writing Grp TI Training initiatives within the AFHSC-Global Emerging Infections Surveillance and Response System: support for IHR (2005) SO BMC PUBLIC HEALTH LA English DT Review AB Training is a key component of building capacity for public health surveillance and response, but has often been difficult to quantify. During fiscal 2009, the Armed Forces Health Surveillance Center, Division of Global Emerging Infections Surveillance and Response System (AFHSC-GEIS) supported 18 partner organizations in conducting 123 training initiatives in 40 countries for 3,130 U.S. military, civilian and host-country personnel. The training assisted with supporting compliance with International Health Regulations, IHR (2005). Training activities in pandemic preparedness, outbreak investigation and response, emerging infectious disease (EID) surveillance and pathogen diagnostic techniques were expanded significantly. By engaging local health and other government officials and civilian institutions, the U.S. military's role as a key stakeholder in global public health has been strengthened and has contributed to EID-related surveillance, research and capacity-building initiatives specified elsewhere in this issue. Public health and emerging infections surveillance training accomplished by AFHSC-GEIS and its Department of Defense (DoD) partners during fiscal 2009 will be tabulated and described. C1 [Otto, Jean L.; Baliga, Priya; Sanchez, Jose L.; Johns, Matthew C.; Blazes, David L.] USAF, Hlth Surveillance Ctr, Silver Spring, MD 20904 USA. [Gray, Gregory C.] Univ Florida, Coll Publ Hlth & Hlth Profess, Dept Environm & Global Hlth, Gainesville, FL 32610 USA. [Lescano, Andres G.] Ctr Med Naval CMST, Naval Med Res Ctr Detachment, Lima, Peru. [Mothershead, Jerry L.] Uniformed Serv Univ Hlth Sci, Ctr Disaster & Humanitarian Assistance Med, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. [Wagar, Eric J.] Attent MRU, US Embassy, Nairobi 00621, Kenya. Makerere Univ, Walter Reed Project, Influenza Res Programme, Kampala, Uganda. Univ Iowa, Ctr Emerging Infect Dis, Coralville, IA 52241 USA. USN, Hlth Res Ctr, San Diego, CA 92106 USA. Med Brigade USAMEDDAC Korea, Unit 15281, APO, AP 96205 USA. Publ Hlth Reg Europe, CMR 402, APO, AE 09180 USA. USN, Environm Prevent Med Unit 2, Norfolk, VA 23511 USA. Pacific AF, Hickam AFB, HI 96853 USA. USAF, Sch Aerosp Med, Epidemiol Consult Serv, Brooks City Base, TX 78235 USA. Naval Med Res Unit 3, Cairo 11517, Egypt. Univ Buea, Dept Biochem & Microbiol, Fac Sci, Buea, South Western, Cameroon. Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. Publ Hlth Reg S, Ft Sam Houston, TX 78234 USA. [AFHSC-GEIS Training Writing Grp] Kompleks Pergudangan DEPKES RI, Naval Med Res Unit 2, Jakarta 10560, Indonesia. RP Baliga, P (reprint author), USAF, Hlth Surveillance Ctr, 11800 Tech Rd, Silver Spring, MD 20904 USA. EM priya.baliga@us.army.mil RI Lescano, Andres/B-8479-2008; Valle, Ruben/A-7512-2013; Bulimo, Wallace/B-1982-2014 OI Lescano, Andres/0000-0001-9779-633X; Bulimo, Wallace/0000-0001-8475-0586 FU FIC NIH HHS [D43 TW007393, D43 TW007393-06] NR 13 TC 0 Z9 0 U1 0 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD MAR 4 PY 2011 VL 11 SU 2 AR S5 DI 10.1186/1471-2458-11-S2-S5 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 759WT UT WOS:000290279900005 PM 21388565 ER PT J AU Sanchez, JL Johns, MC Burke, RL Vest, KG Fukuda, MM Yoon, IK Lon, C Quintana, M Schnabel, DC Pimentel, G Mansour, M Tobias, S Montgomery, JM Gray, GC Saylors, K Ndip, LM Lewis, S Blair, PJ Sjoberg, PA Kuschner, RA Russell, KL Blazes, DL AF Sanchez, Jose L. Johns, Matthew C. Burke, Ronald L. Vest, Kelly G. Fukuda, Mark M. Yoon, In-Kyu Lon, Chanthap Quintana, Miguel Schnabel, David C. Pimentel, Guillermo Mansour, Moustafa Tobias, Steven Montgomery, Joel M. Gray, Gregory C. Saylors, Karen Ndip, Lucy M. Lewis, Sheri Blair, Patrick J. Sjoberg, Paul A. Kuschner, Robert A. Russell, Kevin L. Blazes, David L. CA AFHSC-GEIS Capacity Bldg Writing TI Capacity-building efforts by the AFHSC-GEIS program SO BMC PUBLIC HEALTH LA English DT Review ID HEALTH; SYSTEM AB Capacity-building initiatives related to public health are defined as developing laboratory infrastructure, strengthening host-country disease surveillance initiatives, transferring technical expertise and training personnel. These initiatives represented a major piece of the Armed Forces Health Surveillance Center, Division of Global Emerging Infections Surveillance and Response System (AFHSC-GEIS) contributions to worldwide emerging infectious disease (EID) surveillance and response. Capacity-building initiatives were undertaken with over 80 local and regional Ministries of Health, Agriculture and Defense, as well as other government entities and institutions worldwide. The efforts supported at least 52 national influenza centers and other country-specific influenza, regional and U.S.-based EID reference laboratories (44 civilian, eight military) in 46 countries worldwide. Equally important, reference testing, laboratory infrastructure and equipment support was provided to over 500 field sites in 74 countries worldwide from October 2008 to September 2009. These activities allowed countries to better meet the milestones of implementation of the 2005 International Health Regulations and complemented many initiatives undertaken by other U.S. government agencies, such as the U.S. Department of Health and Human Services, the U.S. Agency for International Development and the U.S. Department of State. C1 [Sanchez, Jose L.; Johns, Matthew C.; Burke, Ronald L.; Vest, Kelly G.; Fukuda, Mark M.; Russell, Kevin L.; Blazes, David L.] USAF, Hlth Surveillance Ctr, Silver Spring, MD 20910 USA. [Fukuda, Mark M.; Yoon, In-Kyu; Lon, Chanthap] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Quintana, Miguel] USA, Publ Hlth Command Reg S, Ft Sam Houston, TX 78234 USA. [Schnabel, David C.] US Embassy, US Army Med Res Unit Kenya, Attn MRU, Nairobi 00621, Kenya. [Pimentel, Guillermo; Mansour, Moustafa] Naval Med Res Unit 3, Cairo 11517, Egypt. [Tobias, Steven] Kompleks Pergudangan DEPKES RI, Naval Med Res Unit 2, Jakarta 10560, Indonesia. [Montgomery, Joel M.] Ctr Med Naval CMST, Naval Med Res Ctr Detachment Peru, Lima, Peru. [Gray, Gregory C.] Univ Florida, Coll Publ Hlth & Hlth Profess, Dept Environm & Global Hlth, Gainesville, FL 32610 USA. [Saylors, Karen] Global Viral Forecasting Initiat, San Francisco, CA 94104 USA. [Ndip, Lucy M.] Univ Buea, Dept Biochem & Microbiol, Fac Sci, Buea, South Western, Cameroon. [Lewis, Sheri] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD 20723 USA. [Blair, Patrick J.] USN, Hlth Res Ctr, San Diego, CA 92106 USA. [Sjoberg, Paul A.] USAF, Sch Aerosp Med, Publ Hlth & Prevent Med Dept, Brooks City Base, TX 78235 USA. [Kuschner, Robert A.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. Kenya Govt Med Res Ctr, Nairobi 00200, Kenya. Landstuhl Reg Med Ctr, CMR 402, APO, AE 09180 USA. Makerere Univ, Walter Reed Project, Kampala, Uganda. Makerere Univ, Fac Vet Med & Med, Kampala, Uganda. USN, Environm & Prevent Med Unit, Norfolk, VA 23511 USA. PharmAccess Fdn, Dar Es Salaam, Tanzania. Tanzania Peoples Def Forces, Def Forces Headquarters Med Serv, Dar Es Salaam, Tanzania. USA, Med Dept Act & Med Brigade 65, Unit 15281, APO, AP 96205 USA. USA, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. USA, Publ Hlth Command Reg Europe, APO, AE 09180 USA. [AFHSC-GEIS Capacity Bldg Writing] USA, Publ Hlth Command Reg Pacific, Unit 45006, APO, AP 96343 USA. RP Sanchez, JL (reprint author), USAF, Hlth Surveillance Ctr, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Toti.Sanchez@us.army.mil RI Valle, Ruben/A-7512-2013; Bulimo, Wallace/B-1982-2014; OI Bulimo, Wallace/0000-0001-8475-0586; Pimentel, Guillermo/0000-0003-2464-1526 NR 19 TC 6 Z9 7 U1 0 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD MAR 4 PY 2011 VL 11 SU 2 AR S4 DI 10.1186/1471-2458-11-S2-S4 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 759WT UT WOS:000290279900004 PM 21388564 ER PT J AU Ballenger-Browning, KK Schmitz, KJ Rothacker, JA Hammer, PS Webb-Murphy, JA Johnson, DC AF Ballenger-Browning, Kara K. Schmitz, Kimberly J. Rothacker, John A. Hammer, Paul S. Webb-Murphy, Jennifer A. Johnson, Douglas C. TI Predictors of Burnout Among Military Mental Health Providers SO MILITARY MEDICINE LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; NATIONAL COMORBIDITY SURVEY; JOB STRESS; SOCIAL SUPPORT; CAREER SATISFACTION; WORKERS; NURSES; STAFF; PSYCHOLOGISTS; PROFESSIONALS AB Mental health treatment of military service members places unique demands on providers as their patients experience combat stress. This study assessed levels and predictors of burnout among mental health providers (N = 97) at military facilities, using a self-administered survey of demographic and work-related measures and the Maslach Burnout Inventory. Burnout levels were comparable to studies of civilian mental health providers but were less severe than those of the Maslach Burnout Inventory normative sample. Working more hours, having more patients with personality disorders, increased patient caseloads, female gender, and being a psychiatrist were predictive of higher burnout scores. Having more confidants at work, a greater percentage of patients with traumatic brain injury, more clinical experience, and being a psychologist predicted lower burnout scores. These findings suggest that burnout levels among military providers are similar to those among civilian providers and may be alleviated by interventions targeting general institutional risk factors. C1 [Ballenger-Browning, Kara K.; Schmitz, Kimberly J.; Rothacker, John A.; Hammer, Paul S.; Webb-Murphy, Jennifer A.] USN, San Diego Med Ctr, NCCOSC, San Diego, CA 92134 USA. [Johnson, Douglas C.] USN, Hlth Res Ctr, San Diego, CA 92106 USA. RP Ballenger-Browning, KK (reprint author), USN, San Diego Med Ctr, NCCOSC, 34960 Bob Wilson Dr,Suite 400, San Diego, CA 92134 USA. NR 51 TC 20 Z9 21 U1 3 U2 13 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2011 VL 176 IS 3 BP 253 EP 260 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 825BN UT WOS:000295246000004 PM 21456349 ER PT J AU Keiser, PB Hamilton, L Broderick, M AF Keiser, Paul B. Hamilton, Lanette Broderick, Michael TI US Military Fatalities due to Neisseria meningitidis: Case Reports and Historical Perspective SO MILITARY MEDICINE LA English DT Article ID C MENINGOCOCCAL POLYSACCHARIDES; HUMAN IMMUNITY; UNITED-STATES; GROUP-B; DISEASE; INFECTIONS; VACCINES AB Meningococcal disease has historically been associated with military populations, particularly during periods of mobilization. Although the U.S. military has now been engaged in conflicts for nearly a decade, the incidence of meningococcal disease in the U.S. population as a whole has reached historic lows. Despite vaccination of all service members in basic military training, the risk of meningococcal disease appears to be equal to or greater than that of the civilian population. These 3 case reports of recent fatalities in the U.S. military and their historic contexts illustrate the circumstances under which meningococcus can strike and highlight the need for continued vigilance in military populations. C1 [Keiser, Paul B.] Walter Reed Army Inst Res, Dept Meningococcal Vaccines, Silver Spring, MD 20910 USA. [Hamilton, Lanette] Tripler Army Med Ctr, Dept Microbiol Serv, Honolulu, HI 96859 USA. [Broderick, Michael] USN, Hlth Res Ctr, Dept Resp Dis Res, San Diego, CA 92106 USA. RP Keiser, PB (reprint author), Walter Reed Army Inst Res, Dept Meningococcal Vaccines, 503 Robert Grant Rd,Room 3A16, Silver Spring, MD 20910 USA. RI Valle, Ruben/A-7512-2013 NR 23 TC 1 Z9 1 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2011 VL 176 IS 3 BP 308 EP 311 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 825BN UT WOS:000295246000013 PM 21456358 ER PT J AU Coon, RG Balansay, MS Faix, DJ Hawksworth, AW Patterson, MB Blair, PJ AF Coon, Robert G. Balansay, Melinda S. Faix, Dennis J. Hawksworth, Anthony W. Patterson, Matthew B. Blair, Patrick J. TI Chlamydophila pneumoniae Infection Among Basic Underwater Demolition/SEAL (BUD/S) Candidates, Coronado, California, July 2008 SO MILITARY MEDICINE LA English DT Article ID COMMUNITY-ACQUIRED PNEUMONIA; CHLAMYDIA-PNEUMONIAE; RESPIRATORY-INFECTION; MILITARY CONSCRIPTS; STRAIN TWAR; CHILDREN; AZITHROMYCIN; EPIDEMIC; RECRUITS; OUTBREAK AB Community-acquired pneumonia can compromise readiness of recruits and service members operating in confined spaces. Often respiratory pathogens are implicated in outbreaks. In July 2008, 5 Basic Underwater Demolition/SEAL students entering an intense period of training at Naval Amphibious Base Coronado reported with clinical symptoms and chest radiographs consistent with pneumonia. Throat and nasal swabs were tested for respiratory pathogens. Molecular evidence indicated that they were infected with the atypical bacterium Chlamydophila pneumoniae. Thirty contemporaneous Basic Underwater Demolition/SEAL students were tested to determine the extent of C pneumoniae infection burden. Five additional cases were captured within this group. The 10 individuals diagnosed with C pneumoniae were treated with a course of azithromycin, Avelox (moxifloxacin hydrochloride), and doxycycline. The cases ended following the isolation of cases and prophylaxis with oral antibiotics. This work highlights the importance of rapid respiratory disease diagnoses to guide the clinical response following the emergence of respiratory infections among military trainees. C1 [Coon, Robert G.; Balansay, Melinda S.; Faix, Dennis J.; Hawksworth, Anthony W.; Blair, Patrick J.] USN, Hlth Res Ctr, Dept Resp Dis Res, San Diego, CA 92106 USA. [Patterson, Matthew B.] USN, Special Warfare Ctr, Coronado, CA 91915 USA. RP Coon, RG (reprint author), USN, Hlth Res Ctr, Dept Resp Dis Res, San Diego, CA 92106 USA. FU Global Emerging Infections System (GEIS) division of the Armed Forces Health Surveillance Center (AFHSC) [0DA705] FX The authors are grateful for the assistance of the clinical staff at the Naval Special Warfare Center, Coronado, CA, and the laboratory staff at the Naval Health Research Center, San Diego, CA. The authors thank CAPT Scott R. Jonson for his helpful edits to the manuscript. Study funding was provided by a project grant from the Global Emerging Infections System (GEIS) division of the Armed Forces Health Surveillance Center (AFHSC) under Work Unit No. 0DA705. NR 26 TC 4 Z9 4 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2011 VL 176 IS 3 BP 320 EP 323 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 825BN UT WOS:000295246000015 PM 21456360 ER PT J AU Vega, V Huynh, UN Holmes, J DeChellis, J Stoyanov, P Piatkowski, D Lee, EW Ogren, J Drusina, N Es-Said, OS AF Vega, V. Huynh, U. Nguyen Holmes, J. DeChellis, J. Stoyanov, P. Piatkowski, D. Lee, E. W. Ogren, J. Drusina, N. Es-Said, O. S. TI Analysis of Heat Effects on Marine Corps AM2 Mat Mechanical Properties SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE LA English DT Article DE AM2 mats; STOVL; 6061-T6 aluminum ID AL 6061-T6 AB Navy AM2 mats are used as portable aircraft landing platforms for the Short Take-off/Vertical Landing (STOVL) aircraft operations. This investigation presents the study performed to determine whether the surface discoloration is a precursor to degradation in the mechanical property of the AM2 mat material. The red discoloration on the mat surfaces had a clear correlation with the decrease in yield strength, ultimate strength, and hardness properties. C1 [Vega, V.] Northrop Grumman Corp, El Segundo, CA 90425 USA. [Huynh, U. Nguyen; Holmes, J.; DeChellis, J.; Stoyanov, P.; Ogren, J.; Es-Said, O. S.] Loyola Marymount Univ, Dept Mech Engn, Los Angeles, CA 90045 USA. [Piatkowski, D.] Naval Air Syst Command, Naval Air Warfare Ctr, Div Aircraft, Lakehurst, NJ 08733 USA. [Lee, E. W.] USN, Naval Air Warfare Ctr, Air Syst Command, Patuxent River, MD 20670 USA. [Drusina, N.] Nortrop Grumman Corp, Redondo Beach, CA 90278 USA. RP Vega, V (reprint author), Northrop Grumman Corp, 1 Hornet Way, El Segundo, CA 90425 USA. EM oessaid@lmu.edu FU National Science Foundation, NSF [EEC-0353668] FX This study was funded by the National Science Foundation, NSF, Grant No. EEC-0353668, Research Experience for Undergraduate (REU) site. NR 7 TC 0 Z9 0 U1 3 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9495 J9 J MATER ENG PERFORM JI J. Mater. Eng. Perform. PD MAR PY 2011 VL 20 IS 2 BP 257 EP 264 DI 10.1007/s11665-010-9669-2 PG 8 WC Materials Science, Multidisciplinary SC Materials Science GA 719ZL UT WOS:000287249900015 ER PT J AU Zhang, JY Yoganandan, N Pintar, FA Guan, YB Shender, B Paskoff, G Laud, P AF Zhang, Jiangyue Yoganandan, Narayan Pintar, Frank A. Guan, Yabo Shender, Barry Paskoff, Glenn Laud, Purushottam TI Effects of tissue preservation temperature on high strain-rate material properties of brain SO JOURNAL OF BIOMECHANICS LA English DT Article DE Brain tissue; High strain-rate; Material properties; Postmortem; Tissue preservation ID FINITE-ELEMENT-ANALYSIS; MECHANICAL-BEHAVIOR; TERRORIST BOMBINGS; BLAST INJURY; HEAD-INJURY; SHEAR; MODEL; CASUALTIES; EXPLOSION; STEM AB Postmortem preservation conditions may be one of factors contributing to wide material property variations in brain tissues in literature. The objective of present study was to determine the effects of preservation temperatures on high strain-rate material properties of brain tissues using the split Hopkinson pressure bar (SHPB). Porcine brains were harvested immediately after sacrifice, sliced into 2 mm thickness, preserved in ice cold (group A, 10 samples) and 37 degrees C (group B, 9 samples) saline solution and warmed to 37 degrees C just prior to the test. A SHPB with tube aluminum transmission bar and semiconductor strain gauges were used to enhance transmitted wave signals. Data were gathered using a digital acquisition system and processed to obtain stress-strain curves. All tests were conducted within 4 h postmortem. The mean strain-rate was 2487 +/- 72 s(-1). A repeated measures model with specimen-level random effects was used to analyze log transformed stress-strain responses through the entire loading range. The mean stress-strain curves with +/- 95% confidence bands demonstrated typical power relationships with the power value of 2.4519 (standard error, 0.0436) for group A and 2.2657 (standard error, 0.0443) for group B, indicating that responses for the two groups are significantly different. Stresses and tangent moduli rose with increasing strain levels in both groups. These findings indicate that storage temperatures affected brain tissue material properties and preserving tissues at 37 degrees C produced a stiffer response at high strain-rates. Therefore, it is necessary to incorporate material properties obtained from appropriately preserved tissues to accurately predict the responses of brain using stress analyses models, such as finite element simulations. Published by Elsevier Ltd. C1 [Zhang, Jiangyue; Yoganandan, Narayan; Pintar, Frank A.; Guan, Yabo] Med Coll Wisconsin, Dept Neurosurg, Milwaukee, WI 53226 USA. [Laud, Purushottam] Med Coll Wisconsin, Dept Biostat, Milwaukee, WI 53226 USA. [Shender, Barry; Paskoff, Glenn] USN, Air Warfare Ctr, Div Aircraft, Patuxent River, MD USA. RP Zhang, JY (reprint author), Med Coll Wisconsin, Dept Neurosurg, Milwaukee, WI 53226 USA. EM jyzhang918@gmail.com FU Office of Naval Research through Naval Air Warfare Center Aircraft Division [N00421-06-C-0046]; VA Medical Research FX This research was supported in part by the Office of Naval Research through Naval Air Warfare Center Aircraft Division contract N00421-06-C-0046 and VA Medical Research. NR 35 TC 13 Z9 13 U1 0 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0021-9290 J9 J BIOMECH JI J. Biomech. PD FEB 3 PY 2011 VL 44 IS 3 BP 391 EP 396 DI 10.1016/j.jbiomech.2010.10.024 PG 6 WC Biophysics; Engineering, Biomedical SC Biophysics; Engineering GA 724BL UT WOS:000287551000005 PM 21055756 ER PT J AU Heltemes, KJ Dougherty, AL MacGregor, AJ Galameau, MR AF Heltemes, Kevin J. Dougherty, Amber L. MacGregor, Andrew J. Galameau, Michael R. TI Alcohol Abuse Disorders Among US Service Members With Mild Traumatic Brain Injury SO MILITARY MEDICINE LA English DT Article ID OPERATION-IRAQI-FREEDOM; COMBAT DEPLOYMENT; SUBSTANCE-ABUSE; NECK INJURIES; DRUG-USE; VETERANS; WAR; AFGHANISTAN; DRINKING; OUTCOMES AB Traumatic brain injury (TBI) has emerged as a preeminent injury in Iraq and Afghanistan. The relationship between TBI and post-injury alcohol use in military personnel has not been clearly defined. The aim of this study was to examine the prevalence of alcohol abuse disorders among combat-injured service members with mild TB! (MTBI). Male U.S. service members with combat injuries were identified from the Expeditionary Medical Encounter Database (n = 3,123). Diagnoses of alcohol abuse disorders were collected from the standard inpatient and ambulatory data records. Overall, a slightly higher proportion of service members with MTBI were diagnosed with an alcohol abuse disorder compared to those with other injury (6.1% vs. 4.9%). In a multivariate analysis, however, it was found that MTBI was not associated with higher levels of alcohol abuse (odds ratio, 1.24; 95% confidence interval, 0.90, 1.70). To better define the consequences of MTBI, future research should include other alcohol dependency measures along with comorbid mental health disorders. C1 [Heltemes, Kevin J.; Dougherty, Amber L.; MacGregor, Andrew J.; Galameau, Michael R.] USN, Hlth Res Ctr, San Diego, CA 92106 USA. RP Heltemes, KJ (reprint author), USN, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. FU U.S. Navy Bureau of Medicine and Surgery, Washington, DC, under Work Unit [60808] FX The authors thank Science Applications International Corporation for its contributions to this work. This study was supported by the U.S. Navy Bureau of Medicine and Surgery, Washington, DC, under Work Unit No. 60808. NR 34 TC 14 Z9 14 U1 2 U2 8 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD FEB PY 2011 VL 176 IS 2 BP 147 EP 150 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 825BL UT WOS:000295245800008 PM 21366075 ER PT J AU Ryan, MAK Jacobson, IG Sevick, CJ Smith, TC Gumbs, GR Conlin, AMS AF Ryan, Margaret A. K. Jacobson, Isabel G. Sevick, Carter J. Smith, Tyler C. Gumbs, Gia R. Conlin, Ava Marie S. CA United States Dept Def Birth Infan TI Health Outcomes among Infants Born to Women Deployed to United States Military Operations during Pregnancy SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Article DE congenital abnormalities; military personnel; reproductive history; women's health ID GULF-WAR VETERANS; CONGENITAL-DEFECTS PROGRAM; BIRTH-DEFECTS; REPRODUCTIVE OUTCOMES; PRENATAL-DIAGNOSIS; SMALLPOX VACCINE; RISK; VIETNAM; ATLANTA; COMBAT AB BACKGROUND: Military professionals who deploy to combat operations may encounter hazards that could adversely affect reproductive health. Pregnant woman are generally exempt from deployment to military operations, however, exposures to such environments may inadvertently occur. We investigated whether maternal deployment during pregnancy was associated with adverse health outcomes in infants. METHODS: The United States Department of Defense Birth and Infant Health Registry identified infants born to military service women between 2002 and 2005, and defined their health outcomes at birth and in the first year of life. Multivariable modeling was applied to investigate preterm birth and birth defects among infants, based on maternal deployment experience during pregnancy. RESULTS: Among 63,056 infants born to military women from 2002 to 2005, 22,596 were born to women with deployment experience in support of the current military operations before, during, or after their pregnancy. These included 2941 infants born to women who appeared to have been deployed some time during their first trimester of pregnancy. Compared to infants born to women who deployed at other times, or never deployed, exposed infants were not more likely to be born preterm, diagnosed with a major birth defect, or diagnosed with a malignancy. CONCLUSIONS: In this exploratory analysis, infants born to women who inadvertently deployed to military operations during their pregnancy were not at increased risk of adverse birth or infant health outcomes. Future analyses should examine outcomes related to specific maternal exposures during deployment, and outcomes among the growing number of infants conceived after deployment. Birth Defects Research (Part A) 91: 117-124, 2011. Published 2010 Wiley-Liss, Inc.(dagger) C1 [Ryan, Margaret A. K.] USN, Hosp Camp Pendleton, Camp Pendleton, CA 92055 USA. [Jacobson, Isabel G.; Sevick, Carter J.; Smith, Tyler C.; Gumbs, Gia R.; Conlin, Ava Marie S.] US Dept Def, Ctr Deployment Hlth Res, USN, Hlth Res Ctr, San Diego, CA USA. RP Ryan, MAK (reprint author), USN, Hosp Camp Pendleton, Occupat Med 5N, Camp Pendleton, CA 92055 USA. EM margaret.ryan@med.navy FU U.S. Department of Defense [60504]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland FX This represents report 09-19, supported by the U.S. Department of Defense, under work unit no. 60504.; In addition to the authors, members of the DoD Birth and Infant Health Registry team include Ania Bukowinski, Kathy Snell, and Brian Feldman. The authors thank Scott L. Seggerman and Greg D. Boyd from the United States Defense Manpower Data Center, Monterey Bay, California, for providing demographic and deployment data, and Michelle Stoia, from the Naval Health Research Center, San Diego, California, for editorial assistance. The authors appreciate the support of the Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland. NR 47 TC 7 Z9 7 U1 1 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD FEB PY 2011 VL 91 IS 2 BP 117 EP 124 DI 10.1002/bdra.20746 PG 8 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA 730LU UT WOS:000288035600007 PM 21319279 ER PT J AU Lee, EU Goswami, R Jones, M Vasudevan, AK AF Lee, E. U. Goswami, R. Jones, M. Vasudevan, A. K. TI Environment-Assisted Cracking in Custom 465 Stainless Steel SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE LA English DT Article; Proceedings Paper CT International Symposium on the Stress Corrosion Cracking in Structural Materials at Ambient Temperatures CY SEP, 2009 CL Padua, ITALY ID STRESS-CORROSION CRACKING; HIGH STRENGTH STEELS; MARAGING STEEL; FRACTURE TOUGHNESS; SOLUTION CHEMISTRY; SUSCEPTIBILITY; BEHAVIOR AB The influence of cold work and aging on the environment-assisted cracking (EAC) behavior and mechanical properties of Custom 465 stainless steel (SS) was studied. Four sets of specimens were made and tested. All specimens were initially solution annealed, rapidly cooled, and refrigerated (SAR condition). The first specimen set was steel in the SAR condition. The second specimen set was aged to the H1000 condition. The third specimen set was 60 pct cold worked, and the fourth specimen set was 60 pct cold worked and aged at temperatures ranging from 755 K to 825 K (482 degrees C to 552 degrees C) for 4 hours in air. The specimens were subsequently subjected to EAC and mechanical testing. The EAC testing was conducted, using the rising step load (RSL) technique, in aqueous solutions of NaCl of pH 7.3 with concentrations ranging from 0.0035 to 3.5 pct at room temperature. The microstructure, dislocation substructure, and crack paths, resulting from the cold work, aging, or subsequent EAC testing, were examined by optical microscopy, transmission electron microscopy (TEM), and scanning electron microscopy (SEM). The aging of the cold-worked specimens induced carbide precipitation within the martensite lath, but not at the lath or packet boundaries. In the aged specimens, as aging temperature rose, the threshold stress intensity for EAC (K-IEAC), elongation, and fracture toughness increased, but the strength and hardness decreased. The K-IEAC also decreased with increasing yield strength and NaCl concentration. In the SAR and H1000 specimens, the EAC propagated along the prior austenite grain boundary, while in the cold-worked and cold-worked and aged specimens, the EAC propagated along the martensite lath, and its packet and prior austenite grain boundaries. The controlling mechanism for the observed EAC was identified to be hydrogen embrittlement. C1 [Lee, E. U.; Jones, M.] USN, Air Warfare Ctr, Div Aircraft, Patuxent River, MD 20670 USA. [Goswami, R.] USN, Res Lab, Washington, DC 20375 USA. [Goswami, R.] Sci Applicat Int Corp, Mclean, VA 22102 USA. [Vasudevan, A. K.] Off Naval Res, Arlington, VA 22203 USA. RP Lee, EU (reprint author), USN, Air Warfare Ctr, Div Aircraft, Patuxent River, MD 20670 USA. EM eun.lee@navy.mil NR 44 TC 4 Z9 5 U1 1 U2 10 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1073-5623 J9 METALL MATER TRANS A JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci. PD FEB PY 2011 VL 42A IS 2 BP 415 EP 423 DI 10.1007/s11661-010-0401-5 PG 9 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 714WO UT WOS:000286839900018 ER PT J AU Heltemes, KJ Dougherty, AL MacGregor, AJ Galameau, MR AF Heltemes, Kevin J. Dougherty, Amber L. MacGregor, Andrew J. Galameau, Michael R. TI Inpatient Hospitalizations of U.S. Military Personnel Medically Evacuated From Iraq and Afghanistan With Combat-Related Traumatic Brain Injury SO MILITARY MEDICINE LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; NECK INJURIES; DEPRESSION; FREEDOM; HEAD; WAR AB Traumatic brain injury (TBI) has been called the signature wound of Operation Iraqi Freedom (OIF) and Operation Enduring Freedom (OEF). The aim of the present study was to describe and assess the incidence of inpatient hospitalizations of U.S. military personnel who were medically evacuated from OIF and OEF with combat-related TBI. Inpatient medical records from 2003 to 2008 were used to determine incident episodes of TBI requiring hospitalization in Landstuhl or CONUS Regional Medical Centers. Denominator data for calculating incidence rates were available from the Defense Manpower Data Center. During the study period, 1,213 U.S. military personnel from OIF and OEF were hospitalized with combat-related TBI. Of these, the largest proportion (40.9%) occurred in 2007. The rate of inpatient hospitalization with TBI was 10.4 per 10,000 troop strength (95% confidence interval: 9.9, 10.9). Future research should examine the incidence of TBI in-theater and include an analysis by injury severity. C1 [Heltemes, Kevin J.; Dougherty, Amber L.; MacGregor, Andrew J.; Galameau, Michael R.] USN, Hlth Res Ctr, San Diego, CA 92106 USA. RP Heltemes, KJ (reprint author), USN, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. FU U.S. Navy Bureau of Medicine and Surgery, Washington, DC under Work Unit [60808] FX We thank Science Applications International Corporation for its contributions to this work. This work was supported by the U.S. Navy Bureau of Medicine and Surgery, Washington, DC, under Work Unit No. 60808. NR 27 TC 9 Z9 9 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD FEB PY 2011 VL 176 IS 2 BP 132 EP 135 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 825BL UT WOS:000295245800005 PM 21366072 ER PT J AU Johnson, DC Polusny, MA Erbes, CR King, D King, L Litz, BT Schnurr, PP Friedman, M Pietrzak, RH Southwick, SM AF Johnson, Douglas C. Polusny, Melissa A. Erbes, Christopher R. King, Daniel King, Lynda Litz, Brett T. Schnurr, Paula P. Friedman, Matthew Pietrzak, Robert H. Southwick, Steven M. TI Development and Initial Validation of the Response to Stressful Experiences Scale SO MILITARY MEDICINE LA English DT Article ID DAVIDSON RESILIENCE SCALE; PSYCHOLOGICAL RESILIENCE; CONSTRUCT-VALIDITY; JOB-SATISFACTION; SOCIAL SUPPORT; LIFE EVENTS; CD-RISC; HARDINESS; PREDICTORS; MODEL AB This report describes the development and initial validation of the Response to Stressful Experiences Scale (RSES), a measure of individual differences in cognitive, emotional, and behavioral responses to stressful life events. We validated this instrument with active-duty and reserve components of military and veterans samples (N = 1,014). The resulting 22-item scale demonstrated sound internal consistency (alpha = 0.91-0.93) and good test-retest reliability (r = 0.87). Factor analysis suggested 5 protective factors: (a) meaning-making and restoration, (b) active coping, (c) cognitive flexibility, (d) spirituality, and (e) self-efficacy. Associations with other measures supported convergent, discriminant, and concurrent validity. In separate military samples, the RSES accounted for unique variance in posttraumatic stress disorder symptoms above and beyond existing scales measuring resilience-related constructs, thereby demonstrating incremental validity. The RSES provides a brief, reliable, and valid measure of individual differences in cognitive, emotional, and behavioral responses to life's most stressful events. C1 [Johnson, Douglas C.] USN, Hlth Res Ctr, San Diego, CA 92106 USA. [Johnson, Douglas C.] Univ Calif San Diego, Sch Med, Dept Psychiat, La Jolla, CA 92037 USA. [Polusny, Melissa A.] Minneapolis VA Med Ctr, Posttraumat Stress Recovery Program, Minneapolis, MN 55417 USA. [Polusny, Melissa A.] Minneapolis VA Med Ctr, Ctr Chron Dis Outcome Res, Minneapolis, MN 55417 USA. [Polusny, Melissa A.; Erbes, Christopher R.] Univ Minnesota, Sch Med, Dept Psychiat, Minneapolis, MN 55454 USA. [King, Daniel; Litz, Brett T.] VA Boston Healthcare Syst 116B2, Natl Ctr Posttraumat Stress Disorder, Behav Sci Div, Boston, MA 02130 USA. [King, Daniel; King, Lynda; Litz, Brett T.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA. [King, Lynda] VA Boston Healthcare Syst 116B3, Natl Ctr Posttraumat Stress Disorder, Womens Hlth Sci Div, Boston, MA 02130 USA. [Schnurr, Paula P.; Friedman, Matthew] VA Med Ctr, Natl Ctr Posttraumat Stress Disorder, Execut Div, White River Jct, VT 05009 USA. [Schnurr, Paula P.; Friedman, Matthew] Dartmouth Med Sch, Dept Psychiat, Hanover, NH 03755 USA. [Friedman, Matthew] Dartmouth Med Sch, Dept Pharmacol, Hanover, NH 03755 USA. [Pietrzak, Robert H.; Southwick, Steven M.] Vet Adm Med Ctr, Natl Ctr Posttratimat Stress Disorder, Clin Neurosci Div, West Haven, CT 06516 USA. [Pietrzak, Robert H.; Southwick, Steven M.] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06511 USA. RP Johnson, DC (reprint author), USN, Hlth Res Ctr, 140 Sylvester Rd,Bldg 328, San Diego, CA 92106 USA. FU Department of Defense [W81XWH-07-2-003] FX This material is the result of work supported with resources and the use of facilities at the Minneapolis VA Medical Center, Minneapolis, MN; VA Connecticut Healthcare System, West Haven, CT; and VA Boston Healthcare System, Boston, MA. This research was supported in part by a grant from the Department of Defense Congressionally Directed Medical Research Program (CDMRP; W81XWH-07-2-003). NR 35 TC 19 Z9 19 U1 4 U2 9 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD FEB PY 2011 VL 176 IS 2 BP 161 EP 169 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA 825BL UT WOS:000295245800011 PM 21366078 ER PT J AU Smith, TC Jacobson, IG Hooper, TI LeardMann, CA Boyko, EJ Smith, B Gackstetter, GD Wells, TS Amoroso, PJ Gray, GC Riddle, JR Ryan, MAK AF Smith, Tyler C. Jacobson, Isabel G. Hooper, Tomoko I. LeardMann, Cynthia A. Boyko, Edward J. Smith, Besa Gackstetter, Gary D. Wells, Timothy S. Amoroso, Paul J. Gray, Gregory C. Riddle, James R. Ryan, Margaret A. K. CA Millennium Cohort Study Team TI Health impact of US military service in a large population-based military cohort: findings of the Millennium Cohort Study, 2001-2008 SO BMC PUBLIC HEALTH LA English DT Article ID GULF-WAR VETERANS; POSTTRAUMATIC-STRESS-DISORDER; SELF-REPORTED SYMPTOMS; MENTAL-HEALTH; SMALLPOX VACCINATION; COMBAT DEPLOYMENT; LONGITUDINAL ASSESSMENT; CIGARETTE-SMOKING; VIETNAM VETERANS; ERA VETERANS AB Background: Combat-intense, lengthy, and multiple deployments in Iraq and Afghanistan have characterized the new millennium. The US military's all-volunteer force has never been better trained and technologically equipped to engage enemy combatants in multiple theaters of operations. Nonetheless, concerns over potential lasting effects of deployment on long-term health continue to mount and are yet to be elucidated. This report outlines how findings from the first 7 years of the Millennium Cohort Study have helped to address health concerns related to military service including deployments. Methods: The Millennium Cohort Study was designed in the late 1990s to address veteran and public concerns for the first time using prospectively collected health and behavioral data. Results: Over 150 000 active-duty, reserve, and National Guard personnel from all service branches have enrolled, and more than 70% of the first 2 enrollment panels submitted at least 1 follow-up survey. Approximately half of the Cohort has deployed in support of operations in Iraq and Afghanistan. Conclusion: The Millennium Cohort Study is providing prospective data that will guide public health policymakers for years to come by exploring associations between military exposures and important health outcomes. Strategic studies aim to identify, reduce, and prevent adverse health outcomes that may be associated with military service, including those related to deployment. C1 [Smith, Tyler C.; Jacobson, Isabel G.; LeardMann, Cynthia A.; Smith, Besa] USN, Hlth Res Ctr, Ctr Deployment Hlth Res, Dept Def, San Diego, CA 92106 USA. [Hooper, Tomoko I.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Boyko, Edward J.] Seattle Epidemiol Res & Informat Ctr, Dept Vet Affairs Puget Sound Healthcare Syst, Seattle, WA USA. [Gackstetter, Gary D.] Analyt Serv Inc ANSER, Arlington, VA USA. [Wells, Timothy S.; Riddle, James R.] USAF, Res Lab, Wright Patterson AFB, OH 45433 USA. [Amoroso, Paul J.] Madigan Army Med Ctr, Tacoma, WA 98431 USA. [Gray, Gregory C.] Univ Florida, Coll Publ Hlth & Hlth Profess, Dept Environm & Global Hlth, Gainesville, FL USA. [Ryan, Margaret A. K.] Naval Hosp Camp Pendleton, Camp Pendleton, CA USA. RP Smith, TC (reprint author), USN, Hlth Res Ctr, Ctr Deployment Hlth Res, Dept Def, 140 Sylvester Rd, San Diego, CA 92106 USA. EM tyler.c.smith@med.navy.mil FU Department of Defense [60002]; M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland; VA Puget Sound FX This work represents report 09-14, supported by the Department of Defense, under work unit no. 60002. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of the Army, Department of the Air Force, Department of Defense, Department of Veterans Affairs, nor the US Government.; We are indebted to all Millennium Cohort Study participants. We thank Scott L. Seggermanfrom the Management Information Division, Defense Manpower Data Center, Monterey, California. Additionally, we thank Millennium Cohort Team Members Melissa Bagnell, MPH; Gina Creaven, MBA; James Davies; Lacy Farnell; Nisara Granado, MPH, PhD; Gia Gumbs, MPH; Jaime Horton; Sydney Lee, MS; Travis Leleu; Gordon Lynch; Jamie McGrew; Hope McMaster, MA, PhD; Amanda Pietrucha, MPH; Teresa Powell, MS; Amber Seelig, MPH; Katherine Snell; Steven Speigle; Kari Sausedo, MA; Martin White, MPH; James Whitmer; and Charlene Wong, MPH; from the Department of Deployment Health Research and Michelle LeWark, from the Naval Health Research Center, San Diego, California. We also thank the professionals from the US Army Medical Research and Materiel Command, especially those from the Military Operational Medicine Research Program, Fort Detrick, Maryland. We appreciate the support of the Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland. VA Puget Sound provided support for Dr. Boyko's participation in this research. NR 75 TC 17 Z9 17 U1 5 U2 10 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD JAN 31 PY 2011 VL 11 AR 69 DI 10.1186/1471-2458-11-69 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 723LM UT WOS:000287508000002 PM 21281496 ER PT S AU Zhang, W Guo, YL Meth, R Sokoloff, H Pope, A Strat, T Chellappa, R AF Zhang, Wei Guo, Yanlin Meth, Reuven Sokoloff, Harvey Pope, Art Strat, Tom Chellappa, Rama GP IEEE TI VARIABLE REMAPPING OF IMAGES FROM VERY DIFFERENT SOURCES SO 2011 18TH IEEE INTERNATIONAL CONFERENCE ON IMAGE PROCESSING (ICIP) SE IEEE International Conference on Image Processing ICIP LA English DT Proceedings Paper CT 18th IEEE International Conference on Image Processing (ICIP) CY SEP 11-14, 2011 CL Brussels, BELGIUM SP IEEE, IEEE Signal Proc Soc (SPS) AB We present a system which registers image sequences acquired by very different sources, so that multiple views could be transformed to the same coordinates system. This enables the functionality of automatic object identification and confirmation across views and platforms. The capability of the system comes from three ingredients: 1) image context enlargement through temporal integration; 2) robust motion estimation using the G-RANSAC framework with a relaxed correspondence criteria; 3) constrained motion estimation within the G-RANSAC framework. The proposed system has worked successfully on thousands of frames from multiple collections with significant variations in scale and resolution.(1) C1 [Zhang, Wei; Guo, Yanlin; Meth, Reuven; Pope, Art; Strat, Tom] SET Corp, 1005 Glebe Rd, Arlington, VA USA. [Sokoloff, Harvey] Naval Air Syst Command, Patuxent River, MD USA. [Chellappa, Rama] Univ Maryland, Ctr Automat Res CfAR, College Pk, MD 20742 USA. RP Zhang, W (reprint author), SET Corp, 1005 Glebe Rd, Arlington, VA USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1522-4880 BN 978-1-4577-1303-3 J9 IEEE IMAGE PROC PY 2011 BP 1501 EP 1504 PG 4 WC Engineering, Electrical & Electronic; Imaging Science & Photographic Technology SC Engineering; Imaging Science & Photographic Technology GA BYI89 UT WOS:000298962501157 ER PT J AU Mah, ML Armstrong, PR Kim, SS Carney, JR Lightstone, JM Talghader, JJ AF Mah, Merlin L. Armstrong, Philip R. Kim, Sangho S. Carney, Joel R. Lightstone, James M. Talghader, Joseph J. GP IEEE TI Thermal History Sensing inside High-Explosive Environments using Thermoluminescent Microparticles SO 2011 IEEE SENSORS LA English DT Proceedings Paper CT 10th IEEE Conference on Sensors CY OCT 28-31, 2011 CL Limerick, IRELAND SP IEEE, IEEE SENSORS Council, ANALOG DEVICES, Failte Ireland, irelandinspires.com, Silicon Labs, Sci Fdn Ireland (SFI), Intel, Competence Ctr, Microelect ID LIF TLD-100; KINETICS; LUMINESCENCE; ORDER AB Thermoluminescent LiF:Mg,Ti (TLD-100) microparticle sensors are demonstrated to record the thermal history of the region near a detonated high explosive. Microparticles were gamma-irradiated to fill their charge-carrier traps and then exposed to the detonation of 20 g of a plastic bonded explosive formulation containing HMX and Al particles at a test distance of approximately 22 cm from the center of the detonation. The thermal history was reconstructed by measuring the thermoluminescent signature of the traps and matching it to appropriate models. The trap populations derived from luminescence measurements and modeling indicate that the particles experienced a maximum temperature of 240 degrees C, then cooled to 1 degrees C above ambient temperature within 0.4 seconds. The resulting glow curve intensity is calculated to match the observed post-detonation signal to 3% averaged over the comparison values used for reconstruction. C1 [Mah, Merlin L.; Armstrong, Philip R.; Kim, Sangho S.; Talghader, Joseph J.] Univ Minnesota, Minneapolis, MN 55455 USA. [Carney, Joel R.; Lightstone, James M.] Indian Head Div, Naval Surface Warfare Ctr, Indian Head, MD 20640 USA. RP Mah, ML (reprint author), Univ Minnesota, Minneapolis, MN 55455 USA. EM joey@umn.edu FU Defense Threat Reduction Agency [HDTRA1-10-0007]; NSF NNIN; MRFN FX This work was supported by the Defense Threat Reduction Agency (HDTRA1-10-0007). Portions of this work were performed at facilities in the NSF NNIN and MRFN programs. NR 8 TC 2 Z9 2 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-9289-3 PY 2011 BP 1269 EP 1272 PG 4 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA BYR66 UT WOS:000299901200307 ER PT S AU Headrick, WJ Davis, TW Bodkin, MA Dusch, K Fox, RR Wolfe, D AF Headrick, William J. Davis, Timothy W. Bodkin, Michael A. Dusch, Kevin Fox, Robert R. Wolfe, Dan GP IEEE TI Signal Based Domain Specific Language (SBDSL) a proposal for a Next Generation Test SO IEEE AUTOTESTCON 2011: SYSTEMS READINESS TECHNOLOGY CONFERENCE SE IEEE Autotestcon LA English DT Proceedings Paper CT IEEE AUTOTESTCON - Systems Readiness Technology Conference CY SEP 12-15, 2011 CL Baltimore, MD SP Inst Elect & Elect Engineers (IEEE), IEEE Aerosp & Elect Syst Soc (AESS), IEEE Instrumentat & Measurement Soc (IMS) AB Signal Based Domain Specific Language (SBDSL) is a domain specific language which combines the use of ATLAS Signal statements with high-level programming language constructs. The goals of this new language are: facilitate the writing of concurrent test programs, provide a language that is easy to extend with new constructs, maintain backwards compatibility with ATLAS Family of languages, enable interoperability between test stations, and enable engineers' fresh out of college to quickly become productive with a test programming language. This paper will cover how the design of the SBDSL language, SBDSL Integrated Development Environment (IDE) and runtime executable will accomplish these goals and present results from the technology demonstration developed. C1 [Headrick, William J.; Bodkin, Michael A.] Lockheed Martin Global Training & Logist GTL, 100 Global Innovat Circle, Orlando, FL 32825 USA. [Davis, Timothy W.; Fox, Robert R.] NAVAIR, Jacksonville, FL 32221 USA. [Dusch, Kevin] NAVAIR, Kevin Dusch, MD 20620 USA. [Wolfe, Dan] NAVAIR Support Contract, Jacksonville, FL 32221 USA. RP Headrick, WJ (reprint author), Lockheed Martin Global Training & Logist GTL, 100 Global Innovat Circle, Orlando, FL 32825 USA. EM William.J.Headrick@lmco.com; Timothy.W.Davis1@navy.mil; Michael.A.Bodkin@lmco.com; Kevin.Dusch@navy.mil; Robert.R.Fox@navy.mil; Dan.Wolfe@navy.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1088-7725 BN 978-1-4244-9361-6 J9 IEEE AUTOTESTCON PY 2011 BP 240 EP 244 PG 5 WC Engineering, Electrical & Electronic SC Engineering GA BXU56 UT WOS:000297105600038 ER PT S AU Freeman, W Karunasiri, G AF Freeman, Will Karunasiri, Gamani BE Razeghi, M PereLaperne, N Everitt, HO Zavada, JM Manzur, T TI Temperature effects in terahertz step well quantum cascade structures with diagonal optical transitions SO TERAHERTZ EMITTERS, RECEIVERS, AND APPLICATIONS II SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Terahertz Emitters, Receivers, and Applications II CY AUG 21, 2011 CL San Diego, CA SP SPIE DE THz; quantum cascade; step well; diagonal optical transition; lattice temperature; optical gain spectra; electron transport; density matrix; coherence ID LASERS; SEMICONDUCTORS; SUPERLATTICE; TRANSPORT AB Temperature effects in terahertz (THz) step well quantum cascade (QC) structures are investigated. Step well QC structures with diagonal optical transitions that use fast intrawell electron-longitudinal optical (LO) phonon scattering for depopulation are considered. A density matrix method is used to model the electron transport coherence and is incorporated into the Monte Carlo simulations of these structures. A phenomenological dephasing time is also included. The influence of the lattice temperature on the population inversion is modeled and the effects due to gain spectral broadening are also considered. Optical gain greater than typical waveguide resonator thresholds are estimated out to T similar to 200 K. C1 [Freeman, Will] USN, Div Phys, Air Warfare Ctr, China Lake, CA 93555 USA. RP Freeman, W (reprint author), USN, Div Phys, Air Warfare Ctr, China Lake, CA 93555 USA. NR 31 TC 2 Z9 2 U1 0 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-729-2 J9 PROC SPIE PY 2011 VL 8119 AR 81190A DI 10.1117/12.894223 PG 7 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BXB30 UT WOS:000295580400006 ER PT S AU Freeman, W AF Freeman, Will BE Anwar, AFM Dhar, NK Crowe, TW TI Modeling electron transport coherence in one and two-well terahertz step well quantum cascade structures with diagonal optical transitions SO TERAHERTZ PHYSICS, DEVICES, AND SYSTEMS V: ADVANCE APPLICATIONS IN INDUSTRY AND DEFENSE SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Terahertz Physics, Devices, and Systems V - Advance Applications in Industry and Defense CY APR 25-26, 2011 CL Orlando, FL SP SPIE DE THz; quantum cascade; step well; diagonal optical transition; electron transport; density matrix; coherence; dephasing; Monte Carlo ID SCATTERING; LASERS; SEMICONDUCTORS; SUPERLATTICE; ROUGHNESS; INTERFACE; SYSTEMS AB A density matrix and tight binding model along with a Monte Carlo approach are used to model electron transport in one and two-well terahertz (THz) step well quantum cascade (QC) structures. Two new structures were analyzed, a multistep one-well structure and a principally two-well structure. Both of these structures use a diagonal optical transition for improved upper to lower lasing state lifetime ratio and feature a step well injector to provide near unity injection efficiency due to the spatial separation of the wavefunctions. Fast intrawell electron-longitudinal optical (LO)-phonon scattering is used to depopulate the lower lasing state which does not require the use of resonant tunneling. Density matrix Monte Carlo simulations are used to analyze these structures in order to investigate these properties. In these simulations scattering mechanisms including LO-phonon, electron-electron, impurity, and interface roughness scattering are treated semiclassically, while also contributing to dephasing scattering. A phenomenological dephasing time is also included to investigate the influence of dephasing on the electron transport within these structures. Subband populations, electron temperatures, optical gain, and current density are extracted from the simulations. The analysis indicates that it is necessary to include incoherent transport dephasing in order to provide realistic estimates of the transport process because the transport is primarily dominated by transitions between weakly coupled states. In addition, this analysis shows these simplified step well structures are capable of yielding high optical gain similar to 80 cm(-1) while at the same time expected to have relatively low threshold current densities |e|j similar to 380 A/cm(2). C1 USN, Air Warfare Ctr, Div Phys, China Lake, CA 93555 USA. RP Freeman, W (reprint author), USN, Air Warfare Ctr, Div Phys, China Lake, CA 93555 USA. NR 26 TC 1 Z9 1 U1 2 U2 4 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-597-7 J9 PROC SPIE PY 2011 VL 8023 AR 802305 DI 10.1117/12.883559 PG 9 WC Optics; Physics, Applied SC Optics; Physics GA BWU64 UT WOS:000294901700003 ER PT S AU Grisso, BL Salvino, LW Singh, G Singh, G Tansel, IN AF Grisso, Benjamin L. Salvino, Liming W. Singh, Gurjiwan Singh, Gurjashan Tansel, Ibrahim N. BE Kundu, T TI A comparison of impedance and Lamb wave SHM techniques for monitoring structural integrity of and through welded joints SO HEALTH MONITORING OF STRUCTURAL AND BIOLOGICAL SYSTEMS 2011 SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Health Monitoring of Structural and Biological Systems 2011 CY MAR 07-10, 2011 CL San Diego, CA SP SPIE, Amer Soc Mech Engineers DE SHM; damage detection; aluminum; weld; impedance SHM; Lamb wave SHM ID PLATES AB In this study, the feasibility of monitoring the structural integrity of welded thick aluminum plates was experimentally tested using two widely used SHM methods: impedance and Lamb wave analyses. The test structure was fabricated from two 1/4 inch thick aluminum plates welded together, and various structural defects, such as holes and cuts, were applied. At each of these damage steps, data were collected for both the impedance and Lamb wave techniques. Results consistently revealed the impedance method to be sensitive to damage in and through the weld. The envelopes of the Lamb wave signals were calculated using the S-transformation of the time histories. There was significant change to the curves when different defects were added to the plate. Both of the SHM methods studied detected each of the cuts and holes acting to reduce the overall strength of the structure. Each technique also detected the hole damage on the opposite side of the weld as the sensor(s) used for damage detection. The study further verified that surface waves move across welds allowing SHM methods to detect the defects even if the sensors are located on neighboring plates or geometries. C1 [Grisso, Benjamin L.; Salvino, Liming W.] Naval Surface Warfare Ctr, Carderock Div, Bethesda, MD 20817 USA. RP Grisso, BL (reprint author), Naval Surface Warfare Ctr, Carderock Div, 9500 MacArthur Blvd, Bethesda, MD 20817 USA. EM benjamin.grisso@navy.mil NR 18 TC 0 Z9 0 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-546-5 J9 PROC SPIE PY 2011 VL 7984 AR 79840F DI 10.1117/12.880424 PG 8 WC Engineering, Multidisciplinary; Optics SC Engineering; Optics GA BWQ88 UT WOS:000294550700013 ER PT J AU Davis, MC Groshens, TJ AF Davis, Matthew C. Groshens, Thomas J. TI One-Pot Preparation of 2,5-Dichloro-4 '-phenyloxybenzophenone SO SYNTHETIC COMMUNICATIONS LA English DT Article DE Acylation; Friedel-Crafts; mixed anhydride; phosphoric acid; trifluoroacetic anhydride ID PROTON-EXCHANGE MEMBRANES; FRIEDEL-CRAFTS ACYLATION; DERIVATIVES; POLY(P-PHENYLENE)S; ANHYDRIDE AB Friedel-Crafts-type acylation of phenyl ether with 2,5-dichlorobenzoic acid could be accomplished in a single step using trifluoroacetic anhydride and phosphoric acid. The method gave a greater yield (78%) than the conventional two-step process (71%) of acid chloride generation followed by aluminum trichloride-mediated acylation. C1 [Davis, Matthew C.; Groshens, Thomas J.] USN, Chem & Mat Div, Michelson Lab, Air Warfare Ctr, China Lake, CA 93555 USA. RP Davis, MC (reprint author), USN, Chem & Mat Div, Michelson Lab, Air Warfare Ctr, China Lake, CA 93555 USA. EM matthew.davis@navy.mil FU NAWCWD FX The financial support from the In-House Laboratory Independent Research (ILIR) program (NAWCWD) is gratefully acknowledged. Thanks to Ann M. Moorehead and Cynthia M. Kitchens for collecting References 13 and 26. Thanks to Dr. Robert D. Chapman (NAWCWD) for some trifluoroacetic acid used in the NMR studies. NR 29 TC 2 Z9 2 U1 0 U2 3 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0039-7911 J9 SYNTHETIC COMMUN JI Synth. Commun. PY 2011 VL 41 IS 2 BP 255 EP 261 AR PII 931249814 DI 10.1080/00397910903534056 PG 7 WC Chemistry, Organic SC Chemistry GA 695QL UT WOS:000285387600011 ER PT J AU Davis, MC Groshens, TJ AF Davis, Matthew C. Groshens, Thomas J. TI Synthesis of 1-[4-(3-Chlorobenzoyl)phenyl]-2-phenylacetylene SO ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL LA English DT Article C1 [Davis, Matthew C.; Groshens, Thomas J.] USN, Chem & Mat Div, Michelson Lab, Air Warfare Ctr, China Lake, CA 93555 USA. RP Davis, MC (reprint author), USN, Chem & Mat Div, Michelson Lab, Air Warfare Ctr, China Lake, CA 93555 USA. EM matthew.davis@navy.mil FU Office of Naval Research FX This work was supported by an In-house Laboratory Independent Research award from the Office of Naval Research. Thanks to Ann M. Moorehead of the Technical Library for collecting reference 15. NR 23 TC 0 Z9 0 U1 0 U2 1 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0030-4948 J9 ORG PREP PROCED INT JI Org. Prep. Proced. Int. PY 2011 VL 43 IS 3 BP 314 EP 318 AR PII 938542333 DI 10.1080/00304948.2011.582010 PG 5 WC Chemistry, Organic SC Chemistry GA 776LM UT WOS:000291536300009 ER PT J AU Davis, MC Groshens, TJ AF Davis, Matthew C. Groshens, Thomas J. TI Synthesis of p-Quinquephenyl from E,E-1,4-Bis(4-bromophenyl)-1,3-butadiene SO SYNTHETIC COMMUNICATIONS LA English DT Article DE Diels-Alder reaction; oxidative decarboxylation; p-quinquephenyl; p-terphenyl; Suzuki reaction ID CIS-DIHYDROCATECHOL; DERIVATIVES; POLY(P-PHENYLENE); POLYPHENYLENE; ALCOHOLS; SERIES; ACID AB p-Quinquephenyl was synthesized in five steps from E,E-1,4-bis(4-bromophenyl)-1,3-butadiene in 34% overall yield. The butadiene was prepared in six steps from 4-bromobenzaldehyde in 35% overall yield. C1 [Davis, Matthew C.; Groshens, Thomas J.] USN, Chem & Mat Div, Michelson Lab, Air Warfare Ctr, China Lake, CA 93555 USA. RP Davis, MC (reprint author), USN, Chem & Mat Div, Michelson Lab, Air Warfare Ctr, China Lake, CA 93555 USA. EM matthew.davis@navy.mil FU In-House Laboratory Independent Research (ILIR) of the Research and Intelligence Department (NAWCWD) FX The financial support from the In-House Laboratory Independent Research (ILIR) program of the Research and Intelligence Department (NAWCWD) is gratefully acknowledged. Thanks to Dan E. Bliss (NAWCWD) for assistance with the differential scanning calorimeter experiment. NR 39 TC 6 Z9 6 U1 1 U2 4 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0039-7911 EI 1532-2432 J9 SYNTHETIC COMMUN JI Synth. Commun. PY 2011 VL 41 IS 2 BP 206 EP 218 AR PII 931255073 DI 10.1080/00397910903533991 PG 13 WC Chemistry, Organic SC Chemistry GA 695QL UT WOS:000285387600007 ER PT J AU Zhou, JJ Yin, YJ Mansour, AN Zhou, XY AF Zhou, Juanjuan Yin, Yijing Mansour, Azzam N. Zhou, Xiangyang TI Experimental Studies of Mediator-Enhanced Polymer Electrolyte Supercapacitors SO ELECTROCHEMICAL AND SOLID STATE LETTERS LA English DT Article ID ELECTROCHEMICAL SUPERCAPACITOR; IONIC-CONDUCTIVITY; CARBON ELECTRODES; POLYANILINE; TRANSPORT; CAPACITANCE; NANOTUBES; COMPOSITE; LIQUID; SALT AB Mediator-enhanced polymer electrolyte supercapacitors (MEPESCs) were fabricated using poly(ethylene oxide)/LiClO4 as the polymer electrolyte in the porous activated carbon electrodes and a Nafion 117 membrane as a separator. NaI and I-2 were added into the polymer electrolyte as mediators to increase both the conductivity of the polymer electrolyte and the specific charge of the MEPESC. Based on the cyclic voltammetry and galvanostatic charge/discharge measurement tests, the total specific charges of the supercapacitor without and with redox mediators are 45 and 210 C g(-1) within a voltage window of 0.0-1.0 V, respectively, showing a significant enhancement effect for the mediators. (C) 2010 The Electrochemical Society. [DOI: 10.1149/1.3526094] All rights reserved. C1 [Zhou, Juanjuan; Yin, Yijing; Zhou, Xiangyang] Univ Miami, Dept Mech & Aerosp Engn, Coral Gables, FL 33124 USA. [Mansour, Azzam N.] USN, Naval Surface Warfare Ctr, Syst & Mat Power & Protect Branch, Carderock Div, Bethesda, MD 20817 USA. RP Zhou, JJ (reprint author), Univ Miami, Dept Mech & Aerosp Engn, Coral Gables, FL 33124 USA. EM xzhou@miami.edu FU Office of Naval Research (ONR) [N00014-08-1-0332, N00014-08-WX-20797] FX The authors thank the Office of Naval Research (ONR) for financial support for this research under award numbers N00014-08-1-0332 and N00014-08-WX-20797. NR 35 TC 16 Z9 16 U1 2 U2 29 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 SOUTH MAIN STREET, PENNINGTON, NJ 08534 USA SN 1099-0062 J9 ELECTROCHEM SOLID ST JI Electrochem. Solid State Lett. PY 2011 VL 14 IS 3 BP A25 EP A28 DI 10.1149/1.3526094 PG 4 WC Electrochemistry; Materials Science, Multidisciplinary SC Electrochemistry; Materials Science GA 703JL UT WOS:000285974100001 ER PT J AU Prietto, M Tsang, M Hernandez, S Roepke, J Piatkowski, D Lee, E Stoyanov, P Ogren, J Es-Said, OS AF Prietto, M. Tsang, M. Hernandez, S. Roepke, J. Piatkowski, D. Lee, E. Stoyanov, P. Ogren, J. Es-Said, O. S. TI The effects of heat damage of aluminum 6061-T6 AM-2 Mats and High Power Run-Up Anchor SO ENGINEERING FAILURE ANALYSIS LA English DT Article DE 6061 T6 Aluminum; AM-2 Mats; High Power Run-Up Anchor AB Mechanical property measurements were made on used sections of mobile landing surfaces for the vertical take off and landing military aircraft Additionally property measurements were made on used sections of anchors used to restrain aircrafts movement during full power engine operations following maintenance In both cases the material used was aluminum alloy 6061 in the T6 temper Tensile hardness and electrical conductivity tests were performed The landing surfaces were hollow core the top portion showed more degradation than the bottom due to the former being in closer proximity to aircraft exhaust gases The used anchor panels showed significant levels of mechanical degradation falling well below SAE minimum standards (C) 2010 Elsevier Ltd All rights reserved C1 [Prietto, M.; Tsang, M.; Hernandez, S.; Roepke, J.; Stoyanov, P.; Ogren, J.; Es-Said, O. S.] Loyola Marymount Univ, Dept Mech Engn, Los Angeles, CA 90045 USA. [Piatkowski, D.] USN, Air Warfare Ctr, Naval Air Syst Command, Lakehurst, NJ USA. [Lee, E.] USN, Air Warfare Ctr, Naval Air Syst Command, Patuxent River, MD 20670 USA. RP Es-Said, OS (reprint author), Loyola Marymount Univ, Dept Mech Engn, Los Angeles, CA 90045 USA. FU National Science Foundation (NSF) [EEC0353668] FX This work was funded by the National Science Foundation (NSF) Grant No EEC0353668 Research Experience for Undergraduate (REU) Program The authors thank Ms Jasmin Abdulla and Ms Virginia Vega for their help in preparing the manuscript NR 5 TC 3 Z9 3 U1 0 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1350-6307 J9 ENG FAIL ANAL JI Eng. Fail. Anal. PD JAN PY 2011 VL 18 IS 1 BP 124 EP 137 DI 10.1016/j.engfailanal.2010.08.014 PG 14 WC Engineering, Mechanical; Materials Science, Characterization & Testing SC Engineering; Materials Science GA 697AO UT WOS:000285485200014 ER PT S AU Burger, HA AF Burger, Henry A. GP IEEE TI Calculating the Effects of Non-Uniform Ice Accumulation on Radome Performance by Ray Trace Analysis SO 2011 IEEE INTERNATIONAL SYMPOSIUM ON ANTENNAS AND PROPAGATION (APSURSI) SE IEEE Antennas and Propagation Society International Symposium LA English DT Proceedings Paper CT IEEE International Symposium on Antennas and Propagation (APSURSI)/USNC/URSI National Radio Science Meeting CY JUL 03-08, 2011 CL Spokane, WA SP IEEE, IEEE Antennas & Propagat Soc (APS), USNC, URSI DE radome; radome analysis; ray tracing; radome ice AB The general effects of variable-thickness ice accumulation on radome performance have been studied by ray-tracing analysis. Results are presented for both clear ice and rime ice, which accumulate differently on a radome. C1 USN, NAVAIR, Patuxent River, MD 20670 USA. RP Burger, HA (reprint author), USN, NAVAIR, Patuxent River, MD 20670 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1522-3965 BN 978-1-4244-9561-0 J9 IEEE ANTENNAS PROP PY 2011 BP 313 EP 316 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA BXV72 UT WOS:000297298500083 ER PT J AU Landrum, ML Hullsiek, KH Chun, HM Crum-Cianflone, NF Ganesan, A Weintrob, AC Barthel, RV O'Connell, RJ Agan, BK AF Landrum, Michael L. Hullsiek, Katherine Huppler Chun, Helen M. Crum-Cianflone, Nancy F. Ganesan, Anuradha Weintrob, Amy C. Barthel, R. Vincent O'Connell, Robert J. Agan, Brian K. TI The Timing of Hepatitis B Virus (HBV) Immunization Relative to Human Immunodeficiency Virus (HIV) Diagnosis and the Risk of HBV Infection Following HIV Diagnosis SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Article DE hepatitis B vaccines; hepatitis B virus; HIV; immunization; vaccination ID US MILITARY COHORT; UNITED-STATES; PROPENSITY SCORE; HOMOSEXUAL-MEN; VACCINATION; RECOMMENDATIONS; INDIVIDUALS; ADULTS; EPIDEMIOLOGY; MORTALITY AB To assess associations between the timing of hepatitis B virus (HBV) immunization relative to human immunodeficiency virus (HIV) diagnosis and vaccine effectiveness, US Military HIV Natural History Study cohort participants without HBV infection at the time of HIV diagnosis were grouped by vaccination status, retrospectively followed from HIV diagnosis for incident HBV infection, and compared using Cox proportional hazards models. A positive vaccine response was defined as hepatitis B surface antibody level >= 10 IU/L. Of 1,877 participants enrolled between 1989 and 2008, 441 (23%) were vaccinated prior to HIV diagnosis. Eighty percent of those who received vaccine doses only before HIV diagnosis had a positive vaccine response, compared with 66% of those who received doses both before and after HIV and 41% of those who received doses only after HIV (P < 0.01 for both compared with persons vaccinated before HIV only). Compared with the unvaccinated, persons vaccinated only before HIV had reduced risk of HBV infection after HIV diagnosis (hazard ratio = 0.38, 95% confidence interval: 0.20, 0.75). No reduction in HBV infection risk was observed for other vaccination groups. These data suggest that completion of the vaccine series prior to HIV infection may be the optimal strategy for preventing this significant comorbid infection in HIV-infected persons. C1 [Landrum, Michael L.] Brooke Army Med Ctr, Infect Dis Serv, MCHE MDI, Ft Sam Houston, TX 78234 USA. [Landrum, Michael L.; Hullsiek, Katherine Huppler; Crum-Cianflone, Nancy F.; Ganesan, Anuradha; Weintrob, Amy C.; O'Connell, Robert J.; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD USA. [Landrum, Michael L.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Hullsiek, Katherine Huppler] Univ Minnesota, Sch Publ Hlth, Div Biostat, Minneapolis, MN 55455 USA. [Chun, Helen M.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Crum-Cianflone, Nancy F.] USN, Med Ctr, San Diego, CA 92152 USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Bethesda, MD USA. [Weintrob, Amy C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Barthel, R. Vincent] USN, Med Ctr, Portsmouth, VA USA. [O'Connell, Robert J.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Landrum, ML (reprint author), Brooke Army Med Ctr, Infect Dis Serv, MCHE MDI, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM mlandrum@idcrp.org OI Agan, Brian/0000-0002-5114-1669 FU Infectious Disease Clinical Research Program (IDCRP) [IDCRP-000-27]; Department of Defense through Uniformed Services University of the Health Sciences; National Institute of Allergy and Infectious Diseases under Inter-Agency [Y1-AI-5072] FX Support for this work (grant IDCRP-000-27) was provided by the Infectious Disease Clinical Research Program (IDCRP; www.idcrp.org), a Department of Defense program executed through the Uniformed Services University of the Health Sciences. The staff of the IDCRP provided salary support to some of the investigators (M. L. L., K. H. H., N. F. C., A. G., A. C. W., and B. K. A.). This project was funded in whole or in part with federal funds from the National Institute of Allergy and Infectious Diseases under Inter-Agency Agreement Y1-AI-5072. NR 31 TC 10 Z9 10 U1 0 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JAN 1 PY 2011 VL 173 IS 1 BP 84 EP 93 DI 10.1093/aje/kwq326 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 695ZR UT WOS:000285412200009 PM 21051446 ER PT J AU Holst, M Greene, CR Richardson, WJ McDonald, TL Bay, K Schwartz, SJ Smith, G AF Holst, Meike Greene, Charles R., Jr. Richardson, W. John McDonald, Trent L. Bay, Kimberly Schwartz, Steven J. Smith, Grace TI Responses of Pinnipeds to Navy Missile Launches at San Nicolas Island, California SO AQUATIC MAMMALS LA English DT Article DE ddisturbance; launch sounds; missiles; California sea lion; Zalophus californianus; northern elephant seal; Mirounga angustirostris; harbor seal; Phoca vitulina AB To document the responses of pinnipeds to launches of missiles and similar aerial vehicles, three species of pinnipeds were observed during 77 launches from Navy-owned San Nicolas Island off California from August 2001 to October 2008. Pinniped behavior and flight sounds during each launch were recorded by unattended video cameras and acoustic recorders set up around the island's periphery, usually in pairs, as vehicles flew over or near haul-out sites. Multiple logistic regression was used to assess dependence of pinniped responses on received sound, distance from flight path, type of vehicle, and natural factors. The majority of observed California sea lions (Zalophus californianus) startled and showed increased vigilance up to 2 min after each launch; responses often included movement on the beach or into the water and were significantly related to received sound level and distance from the vehicle's closest point of approach. Most observed northern elephant seals (Mirounga angustirostris) showed little reaction to launches and merely raised their heads briefly. Nonetheless, their responses were also related to received sound level and distance from vehicle trajectory. The harbor seal (Phoca vitulina) was the most responsive species. During the majority of launches, most (average 68%; range 7 to 100%) observed harbor seals within similar to 4 km of the launch trajectory left their haul-out site by entering the water; harbor seals hauled out again at the same site several hours after a launch. Within the range of conditions studied, there was no clear correlation between harbor seal response and received sound level or distance from the closest point of approach of the vehicle. Despite these short-term behavioral reactions, the effects of launch operations are likely to have been minor and localized, with no consequences for local pinniped populations as pinniped population sizes on San Nicolas Island are stable or increasing. C1 [Holst, Meike; Richardson, W. John] LGL Ltd, Environm Res Associates, King City, ON L7B 1A6, Canada. [Greene, Charles R., Jr.] Greeneridge Sci Inc, Santa Barbara, CA 93117 USA. [McDonald, Trent L.; Bay, Kimberly] Western EcoSyst Technol Inc, Cheyenne, WY 82001 USA. [Schwartz, Steven J.; Smith, Grace] USN, Air Warfare Ctr, Range Sustainabil Off, Point Mugu Nawc, CA 93042 USA. RP Holst, M (reprint author), LGL Ltd, Environm Res Associates, POB 280,22 Fisher St, King City, ON L7B 1A6, Canada. EM mholst@lgl.com RI McDonald, Trent/F-2885-2014 OI McDonald, Trent/0000-0001-7608-6988 FU Naval Air Warfare Center Weapons Division, Point Mugu, California FX This study was funded by the Naval Air Warfare Center Weapons Division, Point Mugu, California, and was conducted under the provisions of IHAs and LOAs issued by National Marine Fisheries Service. We thank A. Stone, G. Smith, S. Harvill, T. Parisi, and many others at Point Mugu and on San Nicolas Island for their support, assistance, and very positive approach to the monitoring effort. Dr. J. W. Lawson, then of LGL Ltd., helped initiate this study. R. W. Blaylock and R. G. Norman of Greeneridge Sciences processed the acoustic data, and R. E. Elliott of LGL helped with the analysis. Dr. E. A. Becker and R. L. Spaulding of TEC Inc., Santa Barbara, assisted with management and logistical matters. We also thank Dr. K. M. Dudzinski, M. Demarchi (of LGL), and two anonymous reviewers for their comments on this manuscript. NR 28 TC 3 Z9 3 U1 0 U2 8 PU EUROPEAN ASSOC AQUATIC MAMMALS PI MOLINE PA C/O DR JEANETTE THOMAS, BIOLOGICAL SCIENCES, WESTERN ILLIONIS UNIV-QUAD CITIES, 3561 60TH STREET, MOLINE, IL 61265 USA SN 0167-5427 J9 AQUAT MAMM JI Aquat. Mamm. PY 2011 VL 37 IS 2 BP 139 EP 150 DI 10.1578/AM.37.2.2011.139 PG 12 WC Marine & Freshwater Biology; Zoology SC Marine & Freshwater Biology; Zoology GA 784ID UT WOS:000292149400003 ER PT J AU Dougherty, AL MacGregor, AJ Han, PP Heltemes, KJ Galarneau, MR AF Dougherty, Amber L. MacGregor, Andrew J. Han, Peggy P. Heltemes, Kevin J. Galarneau, Michael R. TI Visual dysfunction following blast-related traumatic brain injury from the battlefield SO BRAIN INJURY LA English DT Article DE TBI; ocular and visual disorder; combat injury; military ID SEVERITY SCORE; NECK INJURIES; IMPAIRMENT; SOLDIERS; REGISTRY; HEAD; CARE; IRAQ AB Primary objective: To assess the occurrence of ocular and visual disorders following blast-related traumatic brain injury (TBI) in Operation Iraqi Freedom. Research design: Retrospective cohort study. Methods and procedures: A total of 2254 US service members with blast-related combat injuries were identified for analysis from the Expeditionary Medical Encounter Database. Medical record information near the point of injury was used to assess factors associated with the diagnosis of ocular/visual disorder within 12 months after injury, including severity of TBI. Main outcomes and results: Of 2254 service members, 837 (37.1%) suffered a blast-related TBI and 1417 (62.9%) had other blast-related injuries. Two-hundred and one (8.9%) were diagnosed with an ocular or visual disorder within 12 months after blast injury. Compared with service members with other injuries, odds of ocular/visual disorder were significantly higher for service members with moderate TBI (odds ratio (OR) = 1.58, 95% confidence interval (CI) = 1.02-2.45) and serious to critical TBI (OR = 14.26, 95% CI = 7.00-29.07). Conclusions: Blast-related TBI is strongly associated with visual dysfunction within 1 year after injury and the odds of disorder appears to increase with severity of brain injury. Comprehensive vision examinations following TBI in theatre may be necessary. C1 [Dougherty, Amber L.; MacGregor, Andrew J.; Han, Peggy P.; Heltemes, Kevin J.; Galarneau, Michael R.] USN, Hlth Res Ctr, Dept Med Modeling Simulat & Mission Support, San Diego, CA 92106 USA. RP Dougherty, AL (reprint author), USN, Hlth Res Ctr, Dept Med Modeling Simulat & Mission Support, 140 Sylvester Rd, San Diego, CA 92106 USA. EM amber.dougherty@med.navy.mil FU US Navy Bureau of Medicine and Surgery, Washington, DC [60808] FX Declaration of interest: This work was supported by the US Navy Bureau of Medicine and Surgery, Washington, DC, under Work Unit No. 60808. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of Defense, or the US Government. NR 23 TC 27 Z9 27 U1 1 U2 4 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0269-9052 J9 BRAIN INJURY JI Brain Inj. PD JAN PY 2011 VL 25 IS 1 BP 8 EP 13 DI 10.3109/02699052.2010.536195 PG 6 WC Neurosciences; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA 731JI UT WOS:000288101700002 PM 21117919 ER PT J AU Crum-Cianflone, NF Eberly, LE Duplessis, C Maguire, J Ganesan, A Faix, D Defang, G Bai, Y Iverson, E Lalani, T Whitman, T Blair, PJ Brandt, C Macalino, G Burgess, T AF Crum-Cianflone, Nancy F. Eberly, Lynn E. Duplessis, Chris Maguire, Jason Ganesan, Anuradha Faix, Dennis Defang, Gabriel Bai, Yun Iverson, Erik Lalani, Tahaniyat Whitman, Timothy Blair, Patrick J. Brandt, Carolyn Macalino, Grace Burgess, Timothy TI Immunogenicity of a Monovalent 2009 Influenza A (H1N1) Vaccine in an Immunocompromised Population: A Prospective Study Comparing HIV-Infected Adults with HIV-Uninfected Adults SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID ACTIVE ANTIRETROVIRAL THERAPY; PLACEBO-CONTROLLED TRIAL; ANTIBODY-RESPONSES; DOUBLE-BLIND; HIV-1-INFECTED PATIENTS; IMMUNE-RESPONSE; VIRUS; EFFICACY; INDIVIDUALS; MORTALITY AB Background. Limited data exist on the immunogenicity of the 2009 influenza A (H1N1) vaccine among immunocompromised persons, including those with human immunodeficiency virus (HIV) infection. Methods. We compared the immunogenicity and tolerability of a single dose of the monovalent 2009 influenza A (H1N1) vaccine (strain A/California/7/2009H1N1) between HIV-infected and HIV-uninfected adults 18-50 years of age. The primary end point was an antibody titer of >= 1: 40 at day 28 after vaccination in those with a prevaccination level of <= 1: 10, as measured by hemagglutination-inhibition assay. Geometric mean titers, influenza-like illnesses, and tolerability were also evaluated. Results. One hundred thirty-one participants were evaluated (65 HIV-infected and 66 HIV-uninfected patients), with a median age of 35 years (interquartile range, 27-42 years). HIV-infected persons had a median CD4 cell count of 581 cells/mm(3) (interquartile range, 476-814 cells/mm(3)), and 82% were receiving antiretroviral medications. At baseline, 35 patients (27%) had antibody titers of > 1:10. HIV-infected patients (29 [56%] of 52), compared with HIV-uninfected persons (35 [80%] of 44), were significantly less likely to develop an antibody response (odds ratio, .20; P = .003). Changes in the median geometric mean titer from baseline to day 28 were also significantly lower in HIV-infected patients than in HIV-uninfected persons (75 vs 153; P = .001). Five influenza-like illnesses occurred (2 cases in HIV-infected persons), but none was attributable to the 2009 influenza H1N1 virus. The vaccine was well tolerated in both groups. Conclusions. Despite high CD4 cell counts and receipt of antiretroviral medications, HIV-infected adults generated significantly poorer antibody responses, compared with HIV-uninfected persons. Future studies evaluating a 2-dose series or more-immunogenic influenza A (H1N1) vaccines among HIV-infected adults are needed (ClinicalTrials.gov NCT00996970). C1 [Crum-Cianflone, Nancy F.; Eberly, Lynn E.; Maguire, Jason; Ganesan, Anuradha; Iverson, Erik; Lalani, Tahaniyat; Whitman, Timothy; Brandt, Carolyn; Macalino, Grace] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Ganesan, Anuradha; Whitman, Timothy] Natl Naval Med Ctr, Infect Dis Clin, Bethesda, MD 20084 USA. [Crum-Cianflone, Nancy F.; Duplessis, Chris; Brandt, Carolyn] USN, Med Ctr, Infect Dis Clin, San Diego, CA 92152 USA. [Faix, Dennis; Blair, Patrick J.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Eberly, Lynn E.; Bai, Yun; Iverson, Erik] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Maguire, Jason; Lalani, Tahaniyat] USN, Med Ctr, Infect Dis Clin, Portsmouth, VA, England. RP Crum-Cianflone, NF (reprint author), USN, San Diego Med Ctr, Clin Invest Dept KCA, 34800 Bob Wilson Dr,Ste 5, San Diego, CA 92134 USA. EM nancy.crum@med.navy.mil RI Valle, Ruben/A-7512-2013; OI Eberly, Lynn/0000-0003-4763-330X FU Department of Defense executed through the Uniformed Services University of the Health Sciences; National Institute of Allergy and Infectious Diseases, National Institutes of Health [Y1-AI-5072]; Armed Forces Health Surveillance Center's Global Emerging Infections System [I204_10] FX This work was supported by the Infectious Disease Clinical Research Program, a Department of Defense program executed through the Uniformed Services University of the Health Sciences; the National Institute of Allergy and Infectious Diseases, National Institutes of Health (under Interagency Agreement Y1-AI-5072); and the Armed Forces Health Surveillance Center's Global Emerging Infections System (via project I204_10). NR 49 TC 55 Z9 56 U1 0 U2 4 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JAN 1 PY 2011 VL 52 IS 1 BP 138 EP 146 DI 10.1093/cid/ciq019 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 706JI UT WOS:000286214200021 PM 21148532 ER PT J AU Sullivan, KT Piekiel, NW Chowdhury, S Wu, C Zachariah, MR Johnson, CE AF Sullivan, K. T. Piekiel, N. W. Chowdhury, S. Wu, C. Zachariah, M. R. Johnson, C. E. TI Ignition and Combustion Characteristics of Nanoscale Al/AgIO3: A Potential Energetic Biocidal System SO COMBUSTION SCIENCE AND TECHNOLOGY LA English DT Article DE Biocide; Combustion; Ignition; Nanothermite; Silver iodate; Thermite ID MASS-SPECTROMETRY; SILVER; NANOPARTICLES; COMPOSITES; PHASE AB The authors investigated the ignition and reaction of Al/AgIO3 thermites for potential use in biocidal applications. Rapid-heating wire experiments were performed to measure the ignition temperature and investigate the thermal decomposition of the oxidizer using a T-Jump/TOF Mass Spectrometer and an optical emission setup. Combustion experiments inside a constant-volume pressure cell were also carried out, and the relative performance was compared with other thermite systems. The ignition temperature in air at atmospheric pressure was found to be 1215 +/- 40K. The AgIO3 was found to significantly outperform CuO and Fe2O3 oxidizers in pressurization tests, and this is attributed to the enhanced gas release as the AgIO3 thermally decomposes to release iodine in addition to oxygen. The reacted product was collected to investigate the final state of the products. Transmission electron microscopy and X-ray diffraction were performed to show that the major Ag product species was AgI, and not elemental Ag and I2. The AgI was found to be surface exposed to the environment, existing primarily as agglomerated spherical nanoparticles, and was found in some cases to coat the Al2O3 after the reaction. C1 [Sullivan, K. T.; Piekiel, N. W.; Chowdhury, S.; Wu, C.; Zachariah, M. R.] Univ Maryland, Dept Mech Engn, College Pk, MD 20740 USA. [Zachariah, M. R.] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20740 USA. [Johnson, C. E.] USN, Chem & Mat Div, Air Warfare Ctr, China Lake, CA USA. RP Zachariah, MR (reprint author), Univ Maryland, Dept Mech Engn, College Pk, MD 20740 USA. EM mrz@umd.edu FU Defense Threat Reduction Agency; NSF FX This work was funded by the Defense Threat Reduction Agency Basic Research Program. The authors also thank Kelvin Higa, Dan Kline, and Dan Bliss at the Naval Air Warfare Center for preparation of some of the thermite materials, and assistance with SEM/EDX and DSC-TGA analysis. They thank Dr. William Fourney for use of the high-speed camera. The authors acknowledge the support of the Maryland NanoCenter and its NispLab. The NispLab is supported in part by the NSF as a MRSEC Shared Experimental Facility. NR 23 TC 30 Z9 30 U1 1 U2 37 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0010-2202 J9 COMBUST SCI TECHNOL JI Combust. Sci. Technol. PY 2011 VL 183 IS 3 BP 285 EP 302 AR PII 931551580 DI 10.1080/00102202.2010.496378 PG 18 WC Thermodynamics; Energy & Fuels; Engineering, Multidisciplinary; Engineering, Chemical SC Thermodynamics; Energy & Fuels; Engineering GA 714QU UT WOS:000286824900006 ER PT B AU Elele, J Hall, D AF Elele, James Hall, David BE Callaos, N Savoie, M Siddique, M Zinn, CD TI Risk-based VV&A Assessment and Mitigation: A Naval Network Security System Test Facility Case Study SO ICT&A 2011/DEMSET 2011: INTERNATIONAL CONFERENCE ON INFORMATION AND COMMUNICATION TECHNOLOGIES AND APPLICATIONS / INTERNATIONAL CONFERENCE ON DESIGN AND MODELING IN SCIENCE, EDUCATION, AND TECHNOLOGY LA English DT Proceedings Paper CT Int Conf on Information and Communication Technologies and Applications / Int Conf on Design and Modeling in Science, Education, and Technology CY NOV 29-DEC 02, 2011 CL Orlando, FL SP Int Inst Informat & Syst DE Model; Simulation; Risk Assessment; Verification; Validation; Accreditation; Risk Mitigation C1 [Elele, James] Naval Air Syst Command, Patuxent River, MD 20670 USA. [Hall, David] SURVICE Engn Co, Ridgecrest, CA USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU INT INST INFORMATICS & SYSTEMICS PI ORLANDO PA 14269 LORD BARCLAY DR, ORLANDO, FL 32837 USA BN 978-1-936338-45-0 PY 2011 BP 107 EP 114 PG 8 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BG8PB UT WOS:000392562500021 ER PT J AU Ding, HP Chen, G Majumdar, AK Sadler, BM Xu, ZY AF Ding, Haipeng Chen, Gang Majumdar, Arun K. Sadler, Brian M. Xu, Zhengyuan TI Modeling of Non-Line-of-Sight Ultraviolet Scattering Channels for Communication (vol 27, pg 1535, 2009) SO IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS LA English DT Correction C1 [Ding, Haipeng; Chen, Gang; Xu, Zhengyuan] Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. [Majumdar, Arun K.] USN, Air Warfare Ctr, Weap Div, China Lake, CA 93555 USA. [Sadler, Brian M.] USA, Res Lab, RDRL CIN, Adelphi, MD 20783 USA. RP Ding, HP (reprint author), Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. EM dxu@ee.ucr.edu; arun.majumdar@navy.mil; brian.sadler@us.army.mil RI Ding, Haipeng/B-7742-2014 NR 1 TC 2 Z9 3 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0733-8716 J9 IEEE J SEL AREA COMM JI IEEE J. Sel. Areas Commun. PD JAN PY 2011 VL 29 IS 1 BP 250 EP 250 DI 10.1109/JSAC.2011.110123 PG 1 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 701TH UT WOS:000285845800023 ER PT J AU Wells, TS Miller, SC Adler, AB Engel, CC Smith, TC Fairbank, JA AF Wells, Timothy S. Miller, Shannon C. Adler, Amy B. Engel, Charles C. Smith, Tyler C. Fairbank, John A. TI Mental health impact of the Iraq and Afghanistan conflicts: A review of US research, service provision, and programmatic responses SO INTERNATIONAL REVIEW OF PSYCHIATRY LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; TRAUMATIC BRAIN-INJURY; SOCIAL ANXIETY DISORDER; NATIONAL-GUARD SOLDIERS; WAR VETERANS; PRIMARY-CARE; COMBAT DEPLOYMENT; D-CYCLOSERINE; LONGITUDINAL ASSESSMENT; MILITARY PERSONNEL AB Although documentation that war inflicts psychological casualties dates back to the American Civil War and earlier, most research began after the Vietnam conflict, when studies focused on post-traumatic stress disorder (PTSD). With ongoing conflicts in Iraq and Afghanistan, there has been significant research to illuminate the epidemiology of war-related psychological casualties. Significant findings include an appreciation for the role combat plays in the development of mental disorders, including PTSD and traumatic brain injury (TBI). Recent research has endeavoured to understand and improve psychological resilience to temper potentially adverse mental health effects of military service in the theatre of combat operations. Over 2 million US service members have now deployed and returned over 3 million times to the Iraq and Afghanistan conflicts. Mental health providers in the Departments of Defense and Veterans Affairs healthcare systems have consequently observed steep increases in mental health service use among these personnel. The Departments have responded aggressively to bolster staffing levels, increase capacity, improve available services, and anticipate future needs. Scientists and clinicians continue efforts to understand the determinants, prevention, recognition, and treatment of combat-related mental disorders. C1 [Wells, Timothy S.; Smith, Tyler C.] USN, Ctr Deployment Hlth Res, Hlth Res Ctr, San Diego, CA 92106 USA. [Miller, Shannon C.] USAF, Vulnerabil Anal Branch, Res Lab, Wright Patterson AFB, OH 45433 USA. [Miller, Shannon C.] Vet Affairs Med Ctr, Cincinnati, OH 45267 USA. [Miller, Shannon C.] Univ Cincinnati, Dept Psychiat & Behav Neurosci, Ctr Treatment Res & Educ Addict Disorders, Cincinnati, OH USA. [Adler, Amy B.] USA, Med Res Unit Europe, Walter Reed Army Inst Res, Heidelberg, Germany. [Engel, Charles C.] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD USA. [Engel, Charles C.] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Deployment Hlth Clin Ctr, Washington, DC 20307 USA. [Fairbank, John A.] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC USA. [Fairbank, John A.] Mid Atlantic VISN 6 Mental Illness Res Educ & Cli, Durham, NC USA. RP Wells, TS (reprint author), USN, Ctr Deployment Hlth Res, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. EM timothy.wells@med.navy.mil RI Fairbank, John/F-8972-2013; Schueter, nicos/A-3625-2014 OI Fairbank, John/0000-0003-2604-7256; NR 91 TC 40 Z9 41 U1 5 U2 22 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0954-0261 J9 INT REV PSYCHIATR JI Int. Rev. Psych. PY 2011 VL 23 IS 2 BP 144 EP 152 DI 10.3109/09540261.2011.558833 PG 9 WC Psychiatry SC Psychiatry GA 755PO UT WOS:000289946800004 PM 21521083 ER PT J AU Abi-Salloum, TY Snell, S Davis, JP Narducci, FA AF Abi-Salloum, T. Y. Snell, S. Davis, J. P. Narducci, F. A. TI Variations of dispersion and transparency in four level N-scheme atomic systems SO JOURNAL OF MODERN OPTICS LA English DT Article DE induced transparency; dispersion; N-scheme; gyroscope ID GROUP-VELOCITY; LIGHT; GAS AB Systems that exhibit positive and negative dispersion are of interest for numerous applications especially when accompanied by transparency. In this work, we study the variation of the sign of the dispersion in the case of a four-level 'N-Scheme' system. The different dynamics of the sign and value of dispersion and transparency are first explored in light of three resonances that we have previously introduced, then studied as a function of the varying strengths of the fields. As an application we consider in this work both passive and active optical gyroscopes. C1 [Davis, J. P.; Narducci, F. A.] Naval Air Syst Command, EO Sensors Div, Patuxent River, MD 20670 USA. [Abi-Salloum, T. Y.; Snell, S.] Widener Univ, Dept Phys & Astron, Chester, PA 19013 USA. RP Narducci, FA (reprint author), Naval Air Syst Command, EO Sensors Div, Bldg 2187,Suite 3190, Patuxent River, MD 20670 USA. EM frank@aps.org FU Office of Naval Research FX Two of us (J.P.D and F.A.N) would like to gratefully acknowledge the financial support from an In House Laboratory Innovative Research (ILIR) grant from the Office of Naval Research. NR 15 TC 4 Z9 4 U1 0 U2 1 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0950-0340 J9 J MOD OPTIC JI J. Mod. Opt. PY 2011 VL 58 IS 21 SI SI BP 2008 EP 2014 DI 10.1080/09500340.2011.603441 PG 7 WC Optics SC Optics GA 866RK UT WOS:000298399200017 ER PT J AU DeSavage, SA Gordon, KH Clifton, EM Davis, JP Narducci, FA AF DeSavage, S. A. Gordon, K. H. Clifton, E. M. Davis, J. P. Narducci, F. A. TI Raman resonances in arbitrary magnetic fields SO JOURNAL OF MODERN OPTICS LA English DT Article DE Raman resonances; cold atoms; atom interferometers ID MAGNETOMETER ATOM INTERFEROMETER AB We study the general problem of Raman resonances in arbitrary magnetic fields for realistic alkali atoms. We first present the details of a model that includes all magnetic sub-levels and their appropriate coupling strengths to two laser fields. The numerical implementation of this model and some of the results are also presented. Our experimental arrangement is described and preliminary measurements are presented. C1 [Clifton, E. M.; Davis, J. P.; Narducci, F. A.] Naval Air Syst Command, EO Sensors Div, Patuxent River, MD 20670 USA. [DeSavage, S. A.; Gordon, K. H.] Anal Inc, Aerosp Mass Properties, N Wales, PA 19454 USA. RP Narducci, FA (reprint author), Naval Air Syst Command, EO Sensors Div, Bldg 2187,Suite 3190,48110 Shaw Rd, Patuxent River, MD 20670 USA. EM frank@aps.org FU AMPAC [N00178-06D-4679-4Y01]; Office of Naval Research [N000421WX20313] FX This work is a collaborative work. The work was co-authored as part of E.M. Clifton, J.P.Davis and FA Narducci's official duties as employees of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105 no copyright protection is available for such works under U.S. law. The work as part of S.A. DeSavage and K.H. Gordon's official duties as Federal Government Contractors is published by permission of AMPAC under Contract Number N00178-06D-4679-4Y01. The US Government retains for itself, and others acting on its behalf, a paid-up, non-exclusive, and irrevocable worldwide license in said article to reproduce, prepare derivative works, distribute copies to the public, and perform publicly and display publicly, by or on behalf of the Government.; We acknowledge financial support from the Office of Naval Research (Section 219 grant and Grant N000421WX20313). We gratefully acknowledge the laboratory assistance from Jeanette Wood. One of us (FAN) gratefully acknowledges useful discussions with Mark Kasevich, Dmitry Budker, Joshua Grossman, Charles Adler, Danielle Braje, Irina Novikova, Michael Larsen and especially Thad Walker. NR 14 TC 3 Z9 3 U1 1 U2 6 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0950-0340 J9 J MOD OPTIC JI J. Mod. Opt. PY 2011 VL 58 IS 21 SI SI BP 2028 EP 2035 DI 10.1080/09500340.2011.606377 PG 8 WC Optics SC Optics GA 866RK UT WOS:000298399200020 ER PT J AU Melcer, T Belnap, B Walker, GJ Konoske, P Galarneau, M AF Melcer, Ted Belnap, Brian Walker, G. Jay Konoske, Paula Galarneau, Michael TI Heterotopic ossification in combat amputees from Afghanistan and Iraq wars: Five case histories and results from a small series of patients SO JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT LA English DT Article DE Afghanistan war; amputation; blast injury; combat amputee; heterotopic ossification; Iraq war; physical medicine; prosthesis; radiograph; rehabilitation ID RISK-FACTORS; PREVALENCE; INJURIES; TRAUMA; CARE AB Heterotopic ossification (HO) is excess bone growth in soft tissues that frequently occurs in the residual limbs of combat amputees injured in Operation Iraqi Freedom and Operation Enduring Freedom, or Iraq and Afghanistan wars, respectively. HO can interfere with prosthetic use and walking and delay patient rehabilitation. This article describes symptomatic and/or radiographic evidence of HO in a patient series of combat amputees rehabilitating at a military amputee care clinic (27 patients/33 limbs). We conducted a retrospective review of patient records and physician interviews to document evidence of HO symptoms in these limbs (e.g., pain during prosthetic use, skin breakdown). Results showed HO-related symptoms in 10 of the 33 residual limbs. Radiographs were available for 25 of the 33 limbs, and a physician identified at least moderate HO in 15 of the radiographs. However, 5 of the 15 patients who showed at least moderate radiographic HO did not report adverse symptoms. Five individual patient histories described HO onset, symptoms, treatments, and outcomes. These case histories illustrated how HO location relative to pressure-sensitive/pressure-tolerant areas of the residual limb may determine whether patients experienced symptoms. These histories revealed the uncommon but novel finding of potential benefits of HO for prosthetic suspension. C1 [Melcer, Ted; Konoske, Paula; Galarneau, Michael] USN, Hlth Res Ctr, Med Modeling Simulat & Mission Support Dept, San Diego, CA 92106 USA. [Belnap, Brian] USN, San Diego Med Ctr, Comprehens Complex & Casualty Care Ctr, San Diego, CA 92106 USA. [Walker, G. Jay] Sci Applicat Int Corp, Mclean, VA 22102 USA. RP Melcer, T (reprint author), USN, Hlth Res Ctr, Med Modeling Simulat & Mission Support Dept, 140 Sylvester Rd, San Diego, CA 92106 USA. EM ted.melcer@med.navy.mil FU Office of Naval Research, Arlington, Virginia [60332] FX This material is the result of work supported with resources of the Office of Naval Research, Arlington, Virginia, under work unit No. 60332. NR 27 TC 4 Z9 4 U1 0 U2 4 PU JOURNAL REHAB RES & DEV PI BALTIMORE PA DEPT OF VETERANS AFFAIRS REHABIL RES & DEVELOP CTR 103 SOUTH GAY STREET, BALTIMORE, MD 21202-4051 USA SN 0748-7711 J9 J REHABIL RES DEV JI J. Rehabil. Res. Dev. PY 2011 VL 48 IS 1 BP 1 EP 11 DI 10.1682/JRRD.2010.03.0033 PG 11 WC Rehabilitation SC Rehabilitation GA 719SG UT WOS:000287228700001 PM 21328158 ER PT J AU MacGregor, AJ Dougherty, AL Morrison, RH Quinn, KH Galarneau, MR AF MacGregor, Andrew J. Dougherty, Amber L. Morrison, Rosemary H. Quinn, Kimberly H. Galarneau, Michael R. TI Repeated concussion among US military personnel during Operation Iraqi Freedom SO JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT LA English DT Article DE blast; combat; concussion; concussive injury; deployment; head injury; head trauma; military; multiple; severity; traumatic brain injury AB Concussions are a predominant injury of the conflicts in Iraq and Afghanistan. The aims of this study were to describe repeated concussive events among U.S. military personnel injured in Operation Iraqi Freedom and examine subsequent healthcare utilization. We reviewed clinical records from the Expeditionary Medical Encounter Database to identify servicemembers with repeat concussions. We abstracted demographic and injury-specific variables, calculated time between events, and identified healthcare utilization from electronic medical databases. Overall, 113 personnel experienced more than one concussion between 2004 and 2008. A majority of these incidents were blast related. The median time between events was 40 days, with 20% experiencing a second event within 2 weeks of the first and 87% within 3 months. Time between events was not associated with severity of the second event. Greater severity of the second concussive event was associated with higher postinjury utilization of mental health and neurology services. This study is one of the first to describe repeated concussions in a combat setting. We found that repeated concussions occur within a short interval among deployed personnel, although the effects of the first event are unclear. Further research is needed to define the effect of repeated concussions on the health of combat veterans. C1 [MacGregor, Andrew J.; Dougherty, Amber L.; Morrison, Rosemary H.; Quinn, Kimberly H.; Galarneau, Michael R.] USN, Hlth Res Ctr, Dept Med Modeling Simulat & Mission Support, San Diego, CA 92106 USA. RP Dougherty, AL (reprint author), USN, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. EM amber.dougherty@med.navy.mil FU Department of Defense [PT090804, 61024] FX This material was based on work supported by the Congressionally Directed Medical Research Programs, Department of Defense (proposal PT090804 under work unit 61024). NR 28 TC 12 Z9 12 U1 0 U2 3 PU JOURNAL REHAB RES & DEV PI BALTIMORE PA DEPT OF VETERANS AFFAIRS REHABIL RES & DEVELOP CTR 103 SOUTH GAY STREET, BALTIMORE, MD 21202-4051 USA SN 0748-7711 J9 J REHABIL RES DEV JI J. Rehabil. Res. Dev. PY 2011 VL 48 IS 10 BP 1269 EP 1277 DI 10.1682/JRRD.2011.01.0013 PG 9 WC Rehabilitation SC Rehabilitation GA V28XL UT WOS:000208713400013 PM 22234670 ER PT J AU Wilfong, ER Lyles, M Rietcheck, RL Arfsten, DP Boeckman, HJ Johnson, EW Doyle, TL Chapman, GD AF Wilfong, E. R. Lyles, M. Rietcheck, R. L. Arfsten, D. P. Boeckman, H. J. Johnson, E. W. Doyle, T. L. Chapman, G. D. TI THE ACUTE AND LONG-TERM EFFECTS OF MIDDLE EAST SAND PARTICLES ON THE RAT AIRWAY FOLLOWING A SINGLE INTRATRACHEAL INSTILLATION SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES LA English DT Article ID DUST STORM EVENTS; SAUDI-ARABIA; BRONCHOALVEOLAR LAVAGE; MILITARY PERSONNEL; PULMONARY TOXICITY; F344 RATS; LUNG; INFLAMMATION; PARTICULATE; INHALATION AB Military personnel deployed in the Middle East have emphasized concerns regarding high levels of dust generated from blowing desert sand and the movement of troops and equipment. Airborne particulate matter levels (PM(10); PM < 10 mu m) in the region may exceed 1500 mu g/m(3), significantly higher than the military exposure guideline (MEG) of 50 mu g/m(3). Increases in PM(10) have been linked to a rise in incidences of asthma, obstructive pulmonary disease, lung cancer, and cardiovascular diseases. Male Sprague-Dawley rats received a single intratracheal (IT) instillation of 1, 5, or 10 mg of Middle East PM(10) collected at a military occupied site in Kuwait, silica (positive control), or titanium dioxide (TiO(2); negative control) suspended in 400 mu l sterile saline, or saline alone (vehicle control). Twenty-four hours, 3 d, 7 d and 6 mo postexposure (n = 15/group), organs including lung were evaluated for histopathological changes and for particle contaminants. Bronchoalveolar fluid (BALF) was also analyzed for cellular and biochemical parameters, including cytokines and chemokines. Instillation of silica resulted in early, pronounced, sustained inflammation indicated by significant increases in levels of total protein and neutrophils, and activities of lactate dehydrogenase activity and beta-glucuronidase activity. Lower magnitude and transient changes using the same markers were observed in animals exposed to TiO(2) and Middle East PM(10). The results suggest that for acute exposures, this Middle East PM(10) is a nuisance-type dust with relatively low toxicity. However, since average deployment of military personnel to the Middle East is 180 d with potential for multiple follow-on tours, chronic exposure studies are needed to fully understand the pulmonary effects associated with Middle East PM exposure. C1 [Wilfong, E. R.] USN Acad, Dept Chem, Annapolis, MD 21402 USA. [Lyles, M.] USN, Bur Med & Surg, Washington, DC USA. [Rietcheck, R. L.] USAF, Res Lab, Tri Serv Res Support, Pathol Sect, Wright Patterson AFB, OH 45433 USA. [Arfsten, D. P.] USN, Air Stn, Navy Drug Screening Lab, Jacksonville, FL USA. [Boeckman, H. J.; Johnson, E. W.; Doyle, T. L.; Chapman, G. D.] USN, Hlth Res Ctr Detachment, Environm Hlth Effects Lab, Wright Patterson AFB, OH USA. RP Wilfong, ER (reprint author), USN Acad, Dept Chem, Annapolis, MD 21402 USA. EM Wilfong@usna.edu FU Defense Health Promotion work unit [60262] FX This work was supported by Defense Health Promotion work unit number 60262. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of the Army, Department of Defense, or the U.S. government. This article is approved for public release, distribution unlimited. The authors are military service members (or employees of the U.S. government). This work was prepared as part of their official duties. Title 17 U.S.C. 105 provides that copyright protection under this title is not available for any work of the United States government. Title 17 U.S.C. 101 defines a U.S. government work as a work prepared by a military service member or employee of the U.S. government as part of that person's official duties. NR 41 TC 10 Z9 10 U1 1 U2 8 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1528-7394 J9 J TOXICOL ENV HEAL A JI J. Toxicol. Env. Health Part A PY 2011 VL 74 IS 20 BP 1351 EP 1365 DI 10.1080/15287394.2010.516239 PG 15 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 865PD UT WOS:000298321900004 PM 21899408 ER PT J AU Stander, VA Thomsen, CJ Merrill, LL Rabenhorst, MM Crouch, JL Milner, JS AF Stander, Valerie A. Thomsen, Cynthia J. Merrill, Lex L. Rabenhorst, Mandy M. Crouch, Julie L. Milner, Joel S. TI Gender and Military Contextual Risk Factors for Intimate Partner Aggression SO MILITARY PSYCHOLOGY LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; CHILD PHYSICAL ABUSE; NAVY RECRUIT SAMPLE; US ARMY SOLDIERS; PREVENTION PROGRAMS; CONFLICT-RESOLUTION; SPOUSAL AGGRESSION; DOMESTIC VIOLENCE; VIETNAM VETERANS; SEXUAL-ABUSE AB This study explored individual and military risk factors for intimate partner aggression (IPA) perpetration among Navy personnel in their second year of service. We found some evidence that job stress was related to higher perpetration among men. Contrary to expectations, ship duty was related to lower perpetration rates, even though it involves more military operational stress and more frequent deployments than does shore duty. Premilitary alcohol problems were a stronger risk factor for men than for women, whereas premilitary patterns of aggressive behavior were a stronger risk factor for women. Recommendations for future research and public health interventions are discussed. C1 [Stander, Valerie A.; Thomsen, Cynthia J.; Merrill, Lex L.] Naval Hlth Res Ctr, San Diego, CA 92106 USA. [Rabenhorst, Mandy M.; Crouch, Julie L.; Milner, Joel S.] No Illinois Univ, Ctr Study Family Violence & Sexual Assault, De Kalb, IL 60115 USA. RP Stander, VA (reprint author), Naval Hlth Res Ctr, Code 163,140 Sylvester Rd, San Diego, CA 92106 USA. EM valerie.stander@med.navy.mil NR 57 TC 3 Z9 3 U1 4 U2 12 PU LAWRENCE ERLBAUM ASSOC INC-TAYLOR & FRANCIS PI PHILADELPHIA PA 325 CHESTNUT STREET, STE 800, PHILADELPHIA, PA 19106 USA SN 0899-5605 J9 MIL PSYCHOL JI Milit. Psychol. PY 2011 VL 23 IS 6 BP 639 EP 658 DI 10.1080/08995605.2011.616808 PG 20 WC Psychology, Multidisciplinary SC Psychology GA 878LW UT WOS:000299259500005 ER PT S AU Smith, J Elele, DJ Hall, D Pedriani, C AF Smith, Jeremy Elele, Dr. James Hall, David Pedriani, Charles BE Kelmelis, EJ TI Applying Risk-Based M&S VV&A Techniques to Test and Laboratory Facilities SO MODELING AND SIMULATION FOR DEFENSE SYSTEMS AND APPLICATIONS VI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Modeling and Simulation for Defense Systems and Applications VI CY APR 26-27, 2011 CL Orlando, FL SP SPIE DE Risk; Verification; Validation; Accreditation; Model; Simulation; Test Facility; Laboratory AB The Department of Defense (DOD) is exercising a risk-based process for verifying, validating and accrediting models and simulations (M&S) used in system acquisition. Test and laboratory facilities can potentially have even greater potential negative consequences to a program than M&S if there are errors present in the test and analysis results, since test results are usually considered closer to the "truth" than M&S results. This paper will discuss how the risk-based M&S verification, validation and accreditation (VV&A) process is being applied to test and laboratory facilities, issues associated with this different application of the process, and thoughts on the broader applicability of risk-based VV&A beyond the current application. C1 [Smith, Jeremy; Elele, Dr. James] IBST, Naval Air Warfare Ctr, Div Aircraft, Battlespace Modeling V&V,BMS Div, Patuxent River, MD 20670 USA. RP Smith, J (reprint author), IBST, Naval Air Warfare Ctr, Div Aircraft, Battlespace Modeling V&V,BMS Div, Patuxent River, MD 20670 USA. EM james.elele@navy.mil NR 4 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-634-9 J9 PROC SPIE PY 2011 VL 8060 AR 80600K DI 10.1117/12.885251 PG 9 WC Computer Science, Interdisciplinary Applications; Optics SC Computer Science; Optics GA BVM98 UT WOS:000291935100015 ER PT J AU Alley, D Mullen, L Laux, A AF Alley, Derek Mullen, Linda Laux, Alan GP IEEE TI Compact, Dual-Wavelength, Non-Line-of-Sight (NLOS) Underwater Imager SO OCEANS 2011 LA English DT Proceedings Paper CT MTS/IEEE OCEANS Conference CY SEP 19-22, 2011 CL Kona, HI SP Marine Technol Soc (MTS), IEEE, OES DE underwater; optical imaging; optical communications; scattering AB High scattering environments, such as fog, sand, and turbid ocean water, severely degrade the performance of typical line-of-sight(LOS)/pseudo-monostatic imaging systems where the laser and receiver are on the same platform. Researchers at NAVAIR have developed a unique non-line-of-sight (NLOS)/bistatic imaging system where the illuminator and receiver are on separate platforms and are linked via wireless optical communication signal that is carried via the target-reflected light. The illuminator is placed close to the target, eliminating a majority of the forward and back scatter that occurs on the way to the target. This system is not hindered by multiple scattering in the path from the object to the receiver which allows it to achieve good image quality through much higher attenuation lengths than typical LOS imaging systems. A compact, dual optical wavelength system has been developed and is currently being tested in a laboratory environment. Results from this testing will be presented and plans for future work will be discussed. C1 [Alley, Derek; Mullen, Linda; Laux, Alan] NAVAIR, EO & Special Mission Sensors Div, Patuxent River, MD USA. RP Alley, D (reprint author), NAVAIR, EO & Special Mission Sensors Div, Patuxent River, MD USA. EM derek.m.alley@navy.mil NR 3 TC 0 Z9 0 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-0-933957-39-8 PY 2011 PG 5 WC Engineering, Multidisciplinary; Engineering, Electrical & Electronic SC Engineering GA BYJ22 UT WOS:000299005801174 ER PT B AU Story, WR Fu, TC Hackett, EE AF Story, W. Rob Fu, Thomas C. Hackett, Erin E. GP ASME TI RADAR MEASUREMENT OF OCEAN WAVES SO OMAE2011: PROCEEDINGS OF THE ASME 30TH INTERNATIONAL CONFERENCE ON OCEAN, OFFSHORE AND ARCTIC ENGINEERING, VOL 6: OCEAN ENGINEERING LA English DT Proceedings Paper CT 30th International Conference on Ocean, Offshore and Arctic Engineering CY JUN 19-24, 2011 CL Rotterdam, NETHERLANDS SP ASME, Ocean Offshore & Arctic Engn Div ID SEA CLUTTER; MICROWAVE-SCATTERING; IMAGES; MODEL; SPECTRA; SURFACE; MARINE; BACKSCATTERING; HEIGHTS; ANGLES AB Over the past two decades a number of advances have been made in the use of radar systems for the measurement of ocean waves, building on early work at universities and the Naval Research Lab (NRL) to investigate the potential for extracting wave field measurements from the sea clutter seen in shipboard radar images. This early work was the foundation for modern wave radar systems, with hardware systems ranging from commercial off the shelf (COTS) incoherent navigation radar to specially developed, calibrated, coherent instrumentation radar and phased-array systems. Software algorithms and image analysis techniques have also been in constant development, which have evolved from 2D analysis of digitized images into modern techniques performing real-time 3D transformation of high resolution images. Most of these systems are being utilized to measure the directional wave spectra, with some systems also providing wave height estimates and sea surface elevation maps. More recently, the Naval Surface Warfare Center, Carderock Division (NSWCCD) and others have begun to utilize these techniques for shipboard measurement of open ocean waves. All these efforts have led to higher fidelity data, as well as data that were previously unobtainable. In this paper we provide an overview and history of the development of COTS incoherent wave radar systems, analysis techniques, and capabilities, from early characterization of sea clutter return to the latest developments in image inversion and sea surface topography. This review and summary provides a foundation on which to develop analysis techniques for the higher fidelity data, using lessons learned to improve future analysis. While not intending to be exhaustive, this paper seeks to highlight the insights gained from both historical and recent applications of these techniques, as well as the difficulties and issues associated with shipboard measurements such as ship motion, logistical constraints, and environmental factors. C1 [Story, W. Rob] Fulcrum Corp, Arlington, VA 22203 USA. [Fu, Thomas C.; Hackett, Erin E.] Naval Surface Warfare Ctr, Carderock Div, Bethesda, MD USA. RP Story, WR (reprint author), Fulcrum Corp, Arlington, VA 22203 USA. FU U.S. Government; ASME disclaims all interest in the U.S. Government's FX This work is in part a work of the U.S. Government. ASME disclaims all interest in the U.S. Government's NR 49 TC 0 Z9 0 U1 0 U2 5 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4438-0 PY 2011 BP 707 EP + PG 4 WC Engineering, Ocean; Engineering, Mechanical SC Engineering GA BDT62 UT WOS:000314793000075 ER PT B AU Faucett, DC Choi, SR AF Faucett, David C. Choi, Sung R. GP ASME TI STRENGTH DEGRADATION OF OXIDE/OXIDE AND SiC/SiC CERAMIC MATRIX COMPOSITES IN CMAS AND CMAS/SALT EXPOSURES SO PROCEEDINGS OF THE ASME TURBO EXPO 2011, VOL 1 LA English DT Proceedings Paper CT ASME Turbo Expo 2011 CY JUN 06-10, 2011 CL Vancouver, CANADA SP ASME, Int Gas Turbine Inst DE CMAS (calcium-magnesium-aluminosilicate); ceramic matrix composites (CMCs); SiC/SiC; N720/alumina; N720/aluminosilicate; oxide/oxide; strength degradation; mechanical testing ID THERMAL BARRIER COATINGS; ELEVATED-TEMPERATURES; DELAMINATION; INFILTRATION; CORROSION; MECHANISM; SUBJECT AB CMAS (Calcium-Magnesium-Aluminosilicate) has shown to induce some deleterious effects on yittria-stabilized-zirconia (YSZ) based thermal barrier coatings (TBCs) of hot section components of aeroengines. The effects were shown to be dependent on the types and operating conditions of engines/components. The work presented here explored how CMAS would affect ceramic matrix composites (CMCs) in terms of strength degradation. Four different, gas-turbine grade CMCs were utilized including two types of MI SiC/SiCs and other two types of oxides/oxides (N720/aluminisilicate and N720/alumina). Test specimens in a simple flexure configuration were CMAS-treated at 1200 degrees C in air under either isothermal or thermal cycling condition. The effects of CMAS were quantified via residual strengths of treated test specimens. Strength degradation with respect to as-received strengths ranged from 10 to 20 % depending on the types of CMCs. It was further observed that significant degradation of strength up to 90% occurred in an oxide/oxide CMC when sodium sulfate was added to CMAS. C1 [Faucett, David C.; Choi, Sung R.] Naval Air Syst Command, Patuxent River, MD 20670 USA. RP Choi, SR (reprint author), Naval Air Syst Command, Patuxent River, MD 20670 USA. EM sung.choil@navy.mil NR 21 TC 0 Z9 0 U1 1 U2 3 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-5461-7 PY 2011 BP 497 EP 504 PG 8 WC Engineering, Mechanical SC Engineering GA BFO06 UT WOS:000320677300044 ER PT B AU Choi, SR Racz, Z AF Choi, Sung R. Racz, Zsolt GP ASME TI EFFECTS OF TARGET SIZE ON FOREIGN OBJECT DAMAGE IN GAS-TURBINE GRADE SILICON NITRIDES BY STEEL BALL PROJECTILES SO PROCEEDINGS OF THE ASME TURBO EXPO 2011, VOL 1 LA English DT Proceedings Paper CT ASME Turbo Expo 2011 CY JUN 06-10, 2011 CL Vancouver, CANADA SP ASME, Int Gas Turbine Inst DE foreign object damage (FOD); impact damage; impact test; silicon nitrides; ceramics; ballistic impact; target size effect ID IMPACT DAMAGE; STRENGTH DEGRADATION; MODEL; CERAMICS; SURFACES; AMBIENT; SPHERES AB Foreign object damage (FOD) phenomena of two gas-turbine grade silicon nitrides (AS800 and SN282) were assessed at ambient temperature applying impact velocities from 20 to 300 m/s using 1.59-mm diameter hardened steel ball projectiles. Targets in a flexural configuration with two different sizes (thicknesses) of 1 and 2 mm were ballistic-impacted under a fully supported condition. The severity of impact damage, as well as the degree of post-impact strength degradation, increased with increasing impact velocity, increased with decreasing target size, and was greater in SN282 than in AS800 silicon nitride. The critical impact velocity where targets fractured catastrophically decreased with decreasing target size and was lower in SN282 than in AS800. Overall, FOD by steel projectiles was significantly less than that by silicon-nitride ceramic counterparts, due to much decreased Hertzian contact stresses. A correlation of backside cracking velocity versus target size was made based on a simplified elastic foundation analysis. C1 [Choi, Sung R.] Naval Air Syst Command, Patuxent River, MD 20670 USA. RP Choi, SR (reprint author), Naval Air Syst Command, Patuxent River, MD 20670 USA. EM sung.choil@navy.mil NR 33 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-5461-7 PY 2011 BP 517 EP 527 PG 11 WC Engineering, Mechanical SC Engineering GA BFO06 UT WOS:000320677300046 ER PT J AU Larson, GE Hammer, PS Conway, TL Schmied, EA Galarneau, MR Konoske, P Webb-Murphy, JA Schmitz, KJ Edwards, N Johnson, DC AF Larson, Gerald E. Hammer, Paul S. Conway, Terry L. Schmied, Emily A. Galarneau, Michael R. Konoske, Paula Webb-Murphy, Jennifer A. Schmitz, Kimberly J. Edwards, Nathan Johnson, Douglas C. TI Predeployment and In-Theater Diagnoses of American Military Personnel Serving in Iraq SO PSYCHIATRIC SERVICES LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH; DEPLOYMENT; SYMPTOMS; METAANALYSIS; ADULTS AB Objective: This purpose of this study was to determine the incidence and types of preexisting mental disorders among military personnel who received mental health services in an Iraqi war zone. Methods: The study examined psychiatric histories of 1,078 American military personnel (Marines, 65%; Army, 23%; Navy, 11%; and Air Force, <1%) deployed to Iraq and seen by in-theater mental health providers between January 2006 and February 2007. Results: Among the 1,078 patients, the most frequent in-theater diagnoses were anxiety (24%), adjustment (23%), and mood (19%) disorders. Twenty-nine percent of the sample (N=308) had a psychiatric diagnosis in their medical records before their first encounter with mental health services in Iraq (Navy patients, 42%; Army patients, 39%; and Marine Corps patients, 23%). The mean time between last predeployment diagnosis and first in-theater mental health encounter was 21 months. For patients with a prior diagnosis, the highest rate of relapse (receipt of the same diagnosis in theater) was for attention-deficit hyperactivity disorder (57%), followed by anxiety disorders (44%)-especially posttraumatic stress disorder (PTSD) (55%)-mood disorders (38%), and adjustment disorders (32%). Conclusions: A significant proportion of military personnel who experienced mental health problems in a combat zone had preexisting psychiatric conditions. Because more than half of predeployment diagnoses were received in the nine months before the in-theater mental health encounter, further study may be advisable to determine whether a time-based algorithm for deployability is needed, particularly for PTSD, for which a high rate of repeat diagnosis in theater was found. (Psychiatric Services 62: 15-21, 2011) C1 [Larson, Gerald E.; Schmied, Emily A.] USN, Hlth Res Ctr, Dept Behav Sci & Epidemiol, San Diego, CA 92152 USA. [Johnson, Douglas C.] USN, Hlth Res Ctr, Dept Warfighter Performance, San Diego, CA 92152 USA. [Conway, Terry L.; Galarneau, Michael R.; Konoske, Paula; Edwards, Nathan] USN, Hlth Res Ctr, Dept Med Modeling Simulat & Mission Support, San Diego, CA 92152 USA. [Hammer, Paul S.; Webb-Murphy, Jennifer A.; Schmitz, Kimberly J.] Ctr Combat & Operat Stress Control, San Diego, CA USA. RP Schmied, EA (reprint author), Dept 163, 140 Sylvester Rd, San Diego, CA 92106 USA. EM emily.schmied@med.navy.mil FU Navy Bureau of Medicine and Surgery FX Funding for this study was provided by the Navy Bureau of Medicine and Surgery. The authors acknowledge the contributions of Robyn M. McRoy, M. A., M. P. H., and Thierry Nedellec in the collection and analysis of study data. The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, the Department of Defense, or the U.S. Government. This research was conducted in compliance with all applicable federal regulations governing the protection of human subjects in research. NR 12 TC 11 Z9 11 U1 0 U2 0 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 1075-2730 J9 PSYCHIAT SERV JI Psychiatr. Serv. PD JAN PY 2011 VL 62 IS 1 BP 15 EP 21 DI 10.1176/appi.ps.62.1.15 PG 7 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychiatry SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychiatry GA 702SX UT WOS:000285917200005 PM 21209294 ER PT S AU Silbert, M Mazzuchi, T Sarkani, S AF Silbert, Mark Mazzuchi, Thomas Sarkani, Shahram BE Drummond, OE TI Comparison of a grid-based filter to a Kalman filter for the state estimation of a maneuvering target SO SIGNAL AND DATA PROCESSING OF SMALL TARGETS 2011 SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Signal and Data Processing of Small Targets CY AUG 23-25, 2011 CL San Diego, CA SP SPIE DE grid-based track filter; constraint-based filter; maneuvering target tracking; Monte Carlo target tracking ID TRACKING AB Providing accurate state estimates of a maneuvering target is an important problem. This problem occurs when tracking maneuvering boats or even people wandering around. In our earlier paper, a specialized grid-based filter (GBF) was introduced as an effective method to produce accurate state estimates of a target moving in two dimensions, while requiring only a two-dimensional grid. The paper showed that this GBF produces accurate state estimates because the filter can capture the kinematic constraints of the target directly, and thus account for them in the estimation process. In this paper, the relative performance of a GBF to a Kalman filter is investigated. The state estimates (position and velocity) from a GBF are compared to those from a Kalman filter, against a maneuvering target. This study will employ the comparison paradigm presented by Kirubarajan and Bar-Shalom. The paradigm incrementally increases the maneuverability of a target to determine how the two different track filters compare as the target becomes more maneuverable. The intent of this study is to determine how maneuverable the target must be to gain the benefit from a GBF over a Kalman filter. The paper will discuss the target motion model, the GBF implementation, and the Kalman filter used for the study. Our results show that the GBF outperforms a Kalman filter, especially as the target becomes more maneuverable. A disadvantage of the GBF is that it is more computational than a Kalman filter. The paper will discuss the grid and sample sizing needed to obtain quality estimates from a GBF. It will be shown that the sizes are much smaller than what may be expected and is quite stable over a large range of sizes. Furthermore, this GBF can exploit parallelization of the computations, making the processing time significantly less. C1 [Silbert, Mark] NAVAIR, Patuxent River, MD 20670 USA. RP Silbert, M (reprint author), NAVAIR, Bldg 2187,48110 Shaw Rd, Patuxent River, MD 20670 USA. EM fusionkram@gmail.com NR 12 TC 0 Z9 0 U1 1 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-81948-747-6 J9 PROC SPIE PY 2011 VL 8137 AR 81370J DI 10.1117/12.892477 PG 10 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA BXY66 UT WOS:000297633200016 ER PT J AU Scheck, C Cheng, C Tran, K Zupan, M AF Scheck, Caroline Cheng, Christopher Kim Tran Zupan, Marc GP TMS TI IMPACT OF ULTRASONIC IMPACT TREATMENT ON A 5456 ALUMINUM ALLOY CHARACTERIZED THROUGH MICRO-SPECIMEN TESTING AND X-RAY TOMOGRAPHY SO TMS2011 SUPPLEMENTAL PROCEEDINGS, VOL 2: MATERIALS FABRICATION, PROPERTIES, CHARACTERIZATION, AND MODELING LA English DT Proceedings Paper CT TMS 140th Annual Meeting and Exhibition CY FEB 27-MAR 03, 2011 CL San Diego, CA SP TMS DE Aluminum; Micro-Tensile; Ultrasonic Impact Treatment; microCT AB Ultrasonic impact treatment (UIT) is a surface treatment that causes severe plastic deformation (SPD). UIT gives excellent parameter control and has a high energy efficiency, unlike similar processes such as shot peening. The objective of this work is to investigate the measured hardness, strength, and void properties of an ultrasonically impacted 5456-J116 aluminum. Micro-indentation is used to map the hardness properties while microsample specimens directly measure tensile mechanical properties. The micro species (3mm in length by 1mm wide with a gage section of 250 mu m(2)) are made at varying distances from the UIT treated surface and tested to characterize the Young's modulus and yield strength. Voids in the gage section of the micro specimens are analyzed before and after testing using novel X-ray tomography. These void characteristics are linked to the yield and plastic deformation behavior of the material. C1 [Scheck, Caroline; Cheng, Christopher; Zupan, Marc] Univ Maryland Baltimore Cty, 1000 Hilltop Circle, Baltimore, MD 21250 USA. [Kim Tran] Naval Surface Warfare Ctr, Carderock Div, Bethesda, MD 20817 USA. RP Scheck, C (reprint author), Univ Maryland Baltimore Cty, 1000 Hilltop Circle, Baltimore, MD 21250 USA. FU NSF [CBET-0821236] FX This research effort was funded in part through NSF grant number CBET-0821236. NR 5 TC 0 Z9 0 U1 0 U2 4 PU JOHN WILEY & SONS PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER, W SUSSEX PO 19 8SQ, ENGLAND BN 978-1-11802-946-6 PY 2011 BP 205 EP 212 PG 8 WC Materials Science, Multidisciplinary SC Materials Science GA BHY36 UT WOS:000327013200026 ER PT J AU Gee, AM Pfalzer, L Stout, N Levy, E McGarvey, C Springer, B Soballe, P Gerber, L AF Gee, A. Morehead Pfalzer, L. Stout, N. Levy, E. McGarvey, C. Springer, B. Soballe, P. Gerber, L. TI Racial Disparities in Physical and Functional Domains in Women with Early Breast Cancer SO CANCER RESEARCH LA English DT Meeting Abstract C1 NIH, Bethesda, MD 20892 USA. Univ Michigan, Flint, MI 48503 USA. Natl Naval Med Ctr, Bethesda, MD USA. CLM Consulting, Rockville, MD USA. Balboa Naval Hosp, San Diego, CA USA. George Mason Univ, Fairfax, VA 22030 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD DEC 15 PY 2010 VL 70 SU 24 MA P1-10-06 DI 10.1158/0008-5472.SABCS10-P1-10-06 PG 1 WC Oncology SC Oncology GA V43QL UT WOS:000209695800458 ER PT J AU Overfelt, PL Halterman, K Feng, SM Bowling, DR AF Overfelt, P. L. Halterman, Klaus Feng, Simin Bowling, D. R. TI Mode bifurcation and fold points of complex dispersion curves for the negative index metamaterial Goubau line SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID LEAKY WAVES; FREQUENCY; GUIDES AB In this paper the complex dispersion curves of the four lowest-order transverse magnetic modes of a dielectric Goubau line (epsilon > 0, mu > 0) are compared with those of a weakly dispersive negative index metamaterial (NIM) Goubau line. The vastly different dispersion curve structure for the NIM Goubau line is characterized by unusual features such as mode bifurcation, complex fold points, both proper and improper complex modes, and merging of complex and real modes. (C) 2010 American Institute of Physics. [doi:10.1063/1.3465330] C1 [Overfelt, P. L.; Halterman, Klaus; Feng, Simin; Bowling, D. R.] USN, Res & Intelligence Dept, Div Phys, Air Warfare Ctr, China Lake, CA 93555 USA. RP Overfelt, PL (reprint author), USN, Res & Intelligence Dept, Div Phys, Air Warfare Ctr, China Lake, CA 93555 USA. EM klaus.halterman@navy.mil RI Halterman, Klaus/G-3826-2012; OI Halterman, Klaus/0000-0002-6355-3134 FU ONR [N0001410-WX-20737]; DOD HPCMP; HPC FX The authors acknowledge G. A. Lindsay, Z. Sechrist, and G. Ostrom for valuable discussions and the support from ONR under Contract No. N0001410-WX-20737, as well as NAVAIR's ILIR program from ONR. K. H. is also supported in part by a grant of HPC resources as part of the DOD HPCMP. NR 37 TC 4 Z9 4 U1 0 U2 4 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD DEC 15 PY 2010 VL 108 IS 12 AR 124310 DI 10.1063/1.3465330 PG 5 WC Physics, Applied SC Physics GA 700UC UT WOS:000285768800103 ER PT J AU Nguyen, VC Chen, L Klaus, H AF Viet Cuong Nguyen Chen, Lang Klaus, Halterman TI Total Transmission and Total Reflection by Zero Index Metamaterials with Defects SO PHYSICAL REVIEW LETTERS LA English DT Article ID REFRACTION; SCATTERING; NIHILITY; LIGHT AB We theoretically investigate microwave transmission through a zero-index metamaterial loaded with dielectric defects. The metamaterial is impedance matched to free space, with the permittivity and permeability tending towards zero over a given frequency range. By simply varying the radii and permittivities of the defects, total transmission or reflection of the impinging electromagnetic wave can be achieved. The proposed defect structure can offer advances in shielding or cloaking technologies without restricting the object's viewpoint. Active control of the observed exotic transmission and reflection signatures can occur by incorporating tunable refractive index materials such as liquid crystals and BaSrTiO(3). C1 [Viet Cuong Nguyen; Chen, Lang] Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore 639798, Singapore. [Klaus, Halterman] USN, Air Warfare Ctr, Div Phys, Res & Intelligence Dept, China Lake, CA 93555 USA. RP Nguyen, VC (reprint author), Nanyang Technol Univ, Sch Mat Sci & Engn, 50 Nanyang Ave, Singapore 639798, Singapore. EM langchen@ntu.edu.sg RI CHEN, LANG/A-2251-2011; Halterman, Klaus/G-3826-2012; OI Nguyen, Viet Cuong/0000-0003-1145-5652; Halterman, Klaus/0000-0002-6355-3134 FU NTU; ONR; HPC as part of the DOD HPCMP FX L. C. acknowledges support from NTU. K. H. is supported in part by ONR and by a grant of HPC resources as part of the DOD HPCMP and would like to thank J. Martin for useful discussions. NR 26 TC 123 Z9 124 U1 15 U2 86 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD DEC 3 PY 2010 VL 105 IS 23 AR 233908 DI 10.1103/PhysRevLett.105.233908 PG 4 WC Physics, Multidisciplinary SC Physics GA 713KL UT WOS:000286736800010 PM 21231467 ER PT J AU Nichols, JF Aralis, H Merino, SG Barrack, MT Stalker-Fader, L Rauh, MJ AF Nichols, Jeanne F. Aralis, Hilary Garcia Merino, Sonia Barrack, Michelle T. Stalker-Fader, Lindsay Rauh, Mitchell J. TI Utility of the Actiheart Accelerometer for Estimating Exercise Energy Expenditure in Female Adolescent Runners SO INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM LA English DT Article DE accelerometry; physical activity assessment; oxygen consumption; athletes ID COMBINED HEART-RATE; PHYSICAL-ACTIVITY; ACTIVITY MONITORS; BONE TURNOVER; CHILDREN; WOMEN; CALIBRATION; AVAILABILITY; VALIDATION; MOVEMENT AB There is a growing need to accurately assess exercise energy expenditure (EEE) in athletic populations that may be at risk for health disorders because of an imbalance between energy intake and energy expenditure. The Actiheart combines heart rate and uniaxial accelerometry to estimate energy expenditure above rest. The authors' purpose was to determine the utility of the Actiheart for predicting EEE in female adolescent runners (N = 39, age 15.7 +/- 1.1 yr). EEE was measured by indirect calorimetry and predicted by the Actiheart during three 8-min stages of treadmill running at individualized velocities corresponding to each runner's training, including recovery, tempo, and 5-km-race pace. Repeated-measures ANOVA with Bonferroni post hoc comparisons across the 3 running stages indicated that the Actiheart was sensitive to changes in intensity (p < .01), but accelerometer output tended to plateau at race pace. Pairwise comparisons of the mean difference between Actiheart- and criterion-measured EEE yielded values of 0.0436, 0.0539, and 0.0753 kcal . kg(-1) min(-1) during recovery, tempo, and race pace, respectively (p < .0001). Bland Altman plots indicated that the Actiheart consistently underestimated EEE except in 1 runner's recovery bout. A linear mixed-model regression analysis with height as a covariate provided an improved EEE prediction model, with the overall standard error of the estimate for the 3 speeds reduced to 0.0101 kcal . kg(-1) . min(-1). Using the manufacturer's equation that combines heart rate and uniaxial motion, the Actiheart may have limited use in accurately assessing EEE, and therefore energy availability, in young, female competitive runners. C1 [Nichols, Jeanne F.; Stalker-Fader, Lindsay; Rauh, Mitchell J.] San Diego State Univ, Sch Exercise & Nutr Sci, San Diego, CA 92182 USA. [Aralis, Hilary] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Garcia Merino, Sonia] Univ Europea Madrid, Fac Phys Act & Sport Sci, Madrid, Spain. [Barrack, Michelle T.] Univ Calif Davis, Grad Grp Nutr Biol, Davis, CA 95616 USA. RP Nichols, JF (reprint author), San Diego State Univ, Sch Exercise & Nutr Sci, San Diego, CA 92182 USA. FU Center for Health and Nutrition Research at the University of California Davis; American College of Sports Medicine, NASA FX This study was funded by grants from the Center for Health and Nutrition Research at the University of California Davis and from the American College of Sports Medicine, NASA Space Physiology Research Program. None of the authors had a personal or financial conflict of interest. NR 34 TC 4 Z9 4 U1 0 U2 11 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1526-484X J9 INT J SPORT NUTR EXE JI Int. J. Sport Nutr. Exerc. Metab. PD DEC PY 2010 VL 20 IS 6 BP 487 EP 495 PG 9 WC Nutrition & Dietetics; Sport Sciences SC Nutrition & Dietetics; Sport Sciences GA 696GR UT WOS:000285430400005 PM 21116021 ER PT J AU Nichols, JM Seaver, M Trickey, ST Scandell, K Salvino, LW Aktas, E AF Nichols, J. M. Seaver, M. Trickey, S. T. Scandell, K. Salvino, L. W. Aktas, E. TI Real-Time Strain Monitoring of a Navy Vessel During Open Water Transit SO JOURNAL OF SHIP RESEARCH LA English DT Article DE fiber optics; U S Navy; vessel management ID SENSORS; SYSTEM AB In this work we describe the installation of a real-time, fiber-optic strain monitoring system aboard a US Navy vessel undergoing sea trials The system is lightweight, unintrusive, corrosion resistant, and provides dynamic strain response measurements from direct current (DC) up to 360 Hz Also described are the data acquisition and subsequent analysis The goals of the study were to demonstrate a fiber-optic strain monitoring system under real world conditions and to better understand the source of deck cracking above an area housing mission-critical components The results of the two-day trial indicate that there exist large stresses in the deck plate during normal ship operation Based on the results, it is clear that ship maneuvers, slewing of the radar located on the deck plate, and Insolation-related effects are not the primary source of the observed stress C1 USN, Res Lab, Washington, DC 20375 USA. [Scandell, K.; Salvino, L. W.] USN, Sea Syst Command, Naval Surface Warfare Ctr, Carderock Div, Bethesda, MD USA. NR 7 TC 5 Z9 5 U1 1 U2 5 PU SOC NAVAL ARCH MARINE ENG PI JERSEY CITY PA 601 PAVONIA AVENUE, JERSEY CITY, NJ 07306 USA SN 0022-4502 J9 J SHIP RES JI J. Ship Res. PD DEC PY 2010 VL 54 IS 4 BP 225 EP 230 PG 6 WC Engineering, Marine; Engineering, Civil SC Engineering GA 683CX UT WOS:000284450400001 ER PT J AU Seelig, AD Jacobson, IG Smith, B Hooper, TI Boyko, EJ Gackstetter, GD Gehrman, P Macera, CA Smith, TC AF Seelig, Amber D. Jacobson, Isabel G. Smith, Besa Hooper, Tomoko I. Boyko, Edward J. Gackstetter, Gary D. Gehrman, Philip Macera, Carol A. Smith, Tyler C. CA Millennium Cohort Study Team TI Sleep Patterns Before, During, and After Deployment to Iraq and Afghanistan SO SLEEP LA English DT Article DE Sleep; deployment; Millennium Cohort; mental health; veterans ID POSTTRAUMATIC-STRESS-DISORDER; MILITARY DEPLOYMENT; MILLENNIUM COHORT; GENERAL-POPULATION; COMBAT DEPLOYMENT; DECISION-MAKING; YOUNG-ADULTS; DURATION; DEPRIVATION; HEALTH AB Study Objectives: To determine the associations between deployment in support of the wars in Iraq and Afghanistan and sleep quantity and quality. Design: Longitudinal cohort study Setting: The Millennium Cohort Study survey is administered via a secure website or US mail. Participants: Data were from 41,225 Millennium Cohort members who completed baseline (2001-2003) and follow-up (2004-2006) surveys. Participants were placed into 1 of 3 exposure groups based on their deployment status at follow-up: nondeployed, survey completed during deployment, or survey completed postdeployment. Interventions: N/A Measurements and Results: Study outcomes were self-reported sleep duration and trouble sleeping, defined as having trouble falling asleep or staying asleep. Adjusted mean sleep duration was significantly shorter among those in the deployed and postdeployment groups compared with those who did not deploy. Additionally, male gender and greater stress were significantly associated with shorter sleep duration. Personnel who completed their survey during deployment or postdeployment were significantly more likely to have trouble sleeping than those who had not deployed. Lower self-reported general health, female gender, and reporting of mental health symptoms at baseline were also significantly associated with increased odds of trouble sleeping. Conclusions: Deployment significantly influenced sleep quality and quantity in this population though effect size was mediated with statistical modeling that included mental health symptoms. Personnel reporting combat exposures or mental health symptoms had increased odds of trouble sleeping. These findings merit further research to increase understanding of temporal relationships between sleep and mental health outcomes occurring during and after deployment. C1 [Seelig, Amber D.; Jacobson, Isabel G.; Smith, Besa; Smith, Tyler C.] USN, Hlth Res Ctr, Dept Deployment Hlth Res, San Diego, CA 92106 USA. [Hooper, Tomoko I.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Boyko, Edward J.] Vet Affairs Puget Sound Hlth Care Syst, Seattle Epidemiol Res & Informat Ctr, Seattle, WA USA. [Gackstetter, Gary D.] Analyt Serv Inc ANSER, Arlington, VA USA. [Gehrman, Philip] Univ Penn, Dept Psychiat, Penn Sleep Ctr, Philadelphia, PA 19104 USA. [Seelig, Amber D.; Macera, Carol A.] San Diego State Univ, Grad Sch Publ Hlth, San Diego, CA 92182 USA. RP Seelig, AD (reprint author), USN, Hlth Res Ctr, Dept Deployment Hlth Res, 140 Sylvester Rd, San Diego, CA 92106 USA. EM amber.seelig@med.navy.mil FU Henry M. Jackson Foundation FX In addition to the authors, the Millennium Cohort Study Team includes Melissa Bagnell, Lacy Farnell, Gia Gumbs, Nisara Granado, Jaime Horton, Kelly Jones, Molly Kelton, Cynthia LeardMann, Travis Leleu, Gordon Lynch, Jamie McGrew, Amanda Pietrucha, Teresa Powell, Donald Sandweiss, Beverly Sheppard, Katherine Snell, Steven Spiegel, Kari Welch, Martin White, James Whitmer, and Charlene Wong, from the Department of Deployment Health Research, Naval Health Research Center, San Diego, CA; Paul Amoroso, from the Madigan Army Medical Center, Tacoma, WA; Gregory Gray, from the College of Public Health and Health Professions, University of Florida, Gainesville, FL; James Riddle; Margaret Ryan from the Naval Hospital Camp Pendleton, Camp Pendleton, CA; and Timothy Wells from the US Air Force Research Laboratory, Wright-Patterson Air Force Base, OH.; The authors thank the Millennium Cohort Study participants, without whom these analyses would not be possible. We thank Scott Seggerman from the Management Information Division, US Defense Manpower Data Center, Monterey, CA; Michelle Stoia from the Naval Health Research Center; and all the professionals from the US Army Medical Research and Materiel Command, especially those from the Military Operational Medicine Research Program, Fort Detrick, MD. We appreciate the support of the Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, MD. NR 41 TC 64 Z9 64 U1 1 U2 11 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PD DEC 1 PY 2010 VL 33 IS 12 BP 1615 EP 1622 PG 8 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 686TZ UT WOS:000284719900006 PM 21120123 ER PT J AU Zhu, JA Krivorotov, IN Halterman, K Valls, OT AF Zhu, Jian Krivorotov, Ilya N. Halterman, Klaus Valls, Oriol T. TI Angular Dependence of the Superconducting Transition Temperature in Ferromagnet-Superconductor-Ferromagnet Trilayers SO PHYSICAL REVIEW LETTERS LA English DT Article ID ODD TRIPLET SUPERCONDUCTIVITY AB The superconducting transition temperature T-c of a ferromagnet (F)-superconductor (S)-ferromagnet trilayer depends on the mutual orientation of the magnetic moments of the F layers. This effect has been previously observed in F/S/F systems as a T-c difference between parallel and antiparallel configurations of the F layers. Here we report measurements of T-c in CuNi/Nb/CuNi trilayers as a function of the angle between the magnetic moments of the CuNi ferromagnets. The observed angular dependence of T-c is in qualitative agreement with a F/S proximity theory that accounts for the odd triplet component of the condensate predicted to arise for noncollinear orientation of the magnetic moments of the F layers. C1 [Zhu, Jian; Krivorotov, Ilya N.] Univ Calif Irvine, Dept Phys & Astron, Irvine, CA 92697 USA. [Halterman, Klaus] USN, Res & Intelligence Dept, Div Phys, Air Warfare Ctr, China Lake, CA 93555 USA. [Valls, Oriol T.] Univ Minnesota, Sch Phys & Astron, Minneapolis, MN 55455 USA. [Valls, Oriol T.] Univ Minnesota, Minnesota Supercomp Inst, Minneapolis, MN 55455 USA. RP Zhu, JA (reprint author), Univ Calif Irvine, Dept Phys & Astron, Irvine, CA 92697 USA. RI Zhu, Jian/C-3248-2012; Halterman, Klaus/G-3826-2012; OI Halterman, Klaus/0000-0002-6355-3134 FU NSF [DMR-0748810, ECCS-1002358]; ONR; DOD HPCMP; HPC FX This work was supported by NSF Grants No. DMR-0748810 and No. ECCS-1002358. K. H. is supported in part by ONR and by a grant of HPC resources as part of the DOD HPCMP. NR 28 TC 36 Z9 36 U1 0 U2 3 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD NOV 10 PY 2010 VL 105 IS 20 AR 207002 DI 10.1103/PhysRevLett.105.207002 PG 4 WC Physics, Multidisciplinary SC Physics GA 678DP UT WOS:000284052700013 PM 21231256 ER PT J AU Crum-Cianflone, NF Roediger, M Hullsiek, KH Ganesan, A Landrum, M Weintrob, A Agan, B Medina, S Rahkola, J Hale, B Janoff, EN AF Crum-Cianflone, Nancy F. Roediger, Mollie Hullsiek, Kathy Huppler Ganesan, Anuradha Landrum, Michael Weintrob, Amy Agan, Brian Medina, Sheila Rahkola, Jeremy Hale, Braden Janoff, Edward N. CA Infect Dis Clinical Res Program HI TI The association of ethnicity with antibody responses to pneumococcal vaccination among adults with HIV infection SO VACCINE LA English DT Article DE Ethnicity; Antibodies; Pneumococcal vaccination; HIV ID IMMUNODEFICIENCY-VIRUS-INFECTION; HIV-1-INFECTED UGANDAN ADULTS; POLYSACCHARIDE VACCINE; RISK-FACTORS; RESISTANCE PATTERNS; CLINICAL-FEATURES; CHARLESTON COUNTY; CONJUGATE VACCINE; SOUTH-CAROLINA; DISEASE AB Ethnicity may be associated with the incidence of pneumococcal infections and the frequency of protective vaccine responses. Earlier studies have suggested that HIV-infected persons of black ethnicity develop less robust immune responses to pneumococcal vaccination that may relate to their higher incidence of invasive disease. We evaluated the association of ethnicity with capsule-specific antibody responses to pneumococcal revaccination, with either the pneumococcal conjugate (PCV) or polysaccharide (PPV) vaccines among 188 HIV-infected adults. The proportion of the 77 African Americans (AA) and 111 Caucasians with comparable virologic and immunologic parameters who achieved a positive immune response (>= 2-fold rise in capsule-specific IgG from baseline with post-vaccination value >= 1 mu g/mL for >= 2 of 4 serotypes) at day 60 after revaccination was similar (43% vs. 49%, respectively, p = 0.65). Results were also similar when vaccine types (PPV and PCV) were examined separately. Mean changes in log(10) transformed IgG levels from baseline to days 60 and 180 post-vaccination were also not significantly different between AA and Caucasians. In summary, in this ethnically diverse cohort with equal access to care, we did not observe differential antibody responses between AA and Caucasian HIV-infected adults after pneumococcal revaccination. Published by Elsevier Ltd. C1 [Crum-Cianflone, Nancy F.] USN, San Diego Med Ctr, Clin Invest Dept KCA, San Diego, CA 92134 USA. [Crum-Cianflone, Nancy F.; Roediger, Mollie; Hullsiek, Kathy Huppler; Ganesan, Anuradha; Landrum, Michael; Weintrob, Amy; Agan, Brian; Medina, Sheila; Hale, Braden] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Roediger, Mollie; Hullsiek, Kathy Huppler] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Bethesda, MD USA. [Landrum, Michael] San Antonio Mil Med Ctr, San Antonio, TX USA. [Weintrob, Amy] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Rahkola, Jeremy; Janoff, Edward N.] Univ Colorado, Mucosal & Vaccine Res Program Colorado MAVRC, Denver, CO 80202 USA. [Hale, Braden] USN, Hlth Res Ctr, San Diego, CA 92134 USA. [Rahkola, Jeremy; Janoff, Edward N.] Denver Vet Affairs Med Ctr, Denver, CO USA. RP Crum-Cianflone, NF (reprint author), USN, San Diego Med Ctr, Clin Invest Dept KCA, 34800 Bob Wilson Dr,Ste 5, San Diego, CA 92134 USA. EM nancy.crum@med.navy.mil OI Agan, Brian/0000-0002-5114-1669 FU Department of Defense (DoD) through the Uniformed Services University of the Health Sciences [IDCRP RV-150]; National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) [Y1-AI-5072]; Veterans Affairs Research Service FX Support for this work (IDCRP RV-150) was provided by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072. Additional support was obtained from the Veterans Affairs Research Service. NR 27 TC 4 Z9 4 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD NOV 10 PY 2010 VL 28 IS 48 BP 7583 EP 7588 DI 10.1016/j.vaccine.2010.09.056 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 696HN UT WOS:000285432600002 PM 20887830 ER PT J AU Pidaparti, RM Aghazadeh, BS Whitfield, A Rao, AS Mercier, GP AF Pidaparti, Ramana M. Aghazadeh, Babak Seyed Whitfield, Angela Rao, A. S. Mercier, Gerald P. TI Classification of corrosion defects in NiAl bronze through image analysis SO CORROSION SCIENCE LA English DT Article DE Nickel; SEM; Modeling Studies; Pitting Corrosion; Acid Corrosion; Corrosion Fatigue ID ATMOSPHERIC CORROSION; PITTING CORROSION; INITIATION; EXPOSURE; ALLOYS; STRESS; DAMAGE AB Corrosion surface damage in the form of pitting and micro-cracks is observed in many metals. Cracks usually initiate from the pits and grow under cyclic stresses and eventually lead to material failure. An image analysis based on wavelet transforms and fractals was used to study the corrosion morphology of nickel aluminum bronze metal under varying corrosion conditions and applied stresses. Image feature parameters were extracted and analyzed to classify the pits/cracks in the metal samples. The results obtained indicate that classification of pits/cracks is possible with image analysis and may be used for correlating service/failure conditions based on corrosion morphology. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Pidaparti, Ramana M.; Aghazadeh, Babak Seyed] Virginia Commonwealth Univ, Dept Mech Engn, Richmond, VA 23284 USA. [Whitfield, Angela; Rao, A. S.; Mercier, Gerald P.] Naval Surface Warfare Ctr, Carderock Div, Dept Alloy Dev & Mech, Bethesda, MD 20817 USA. RP Pidaparti, RM (reprint author), Virginia Commonwealth Univ, Dept Mech Engn, 401 W Main St, Richmond, VA 23284 USA. EM rmpidaparti@vcu.edu FU US National Science Foundation [DMR-0505496]; Office of Naval Research, Virginia FX The first two authors thank US National Science Foundation for supporting this work through a Grant DMR-0505496. The authors also acknowledge the financial support from Dr. Airan Perez, Program Officer, Office of Naval Research, Virginia. NR 24 TC 17 Z9 18 U1 4 U2 14 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0010-938X J9 CORROS SCI JI Corrosion Sci. PD NOV PY 2010 VL 52 IS 11 BP 3661 EP 3666 DI 10.1016/j.corsci.2010.07.017 PG 6 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 659IX UT WOS:000282561300010 ER PT J AU Metzgar, D Baynes, D Myers, CA Kammerer, P Unabia, M Faix, DJ Blair, PJ AF Metzgar, David Baynes, Darcie Myers, Christopher A. Kammerer, Peter Unabia, Michelle Faix, Dennis J. Blair, Patrick J. TI Initial Identification and Characterization of an Emerging Zoonotic Influenza Virus Prior to Pandemic Spread SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID IONIZATION MASS-SPECTROMETRY; A H1N1 VIRUS; RAPID IDENTIFICATION; UNIVERSAL BIOSENSOR; VACCINE STRAINS; HUMANS; PCR; SURVEILLANCE; SENSITIVITY AB Two cases of febrile respiratory illness associated with untypeable influenza A virus were identified in Southern California in March 2009. One was initially detected as influenza virus using an experimental diagnostic device in a clinical trial, while the other was detected at a local reference lab using a diagnostic PCR assay. In both cases, analyses yielded negative results for strain-specific tests targeting circulating strains of influenza A virus (seasonal H1 and H3). These two samples became the first reported cases of the pandemic 2009/H1N1 influenza virus. The first reportable characterization was made from the second collected specimen on 15 April 2009 at the Centers for Disease Control and Prevention central lab using traditional culture and sequencing methods. The novel nature of the strain and its apparent zoonotic origins were initially characterized using the first collected specimen at the Naval Health Research Center in San Diego, CA, on 13 April using an experimental molecular analysis tool, PCR electro-spray ionization-mass spectrometry (PCR/ESI-MS), designed to amplify PCR products from any strain of influenza virus and to generate informative (phylogenetic) strain identifications through mass spectrometry of PCR amplicons. The ability of this high-throughput tool to correctly identify both well-characterized and novel influenza strains offers the possibility to integrate surveillance for emerging strains with on-site rapid diagnosis used for patient management, shortening the times between the emergence of new strains, their detection and identification, and appropriate public health response activities. Here we describe the initial characterization of the pandemic 2009/H1N1 influenza strain and discuss the possible roles of diagnostic tools with discovery potential. C1 [Metzgar, David; Baynes, Darcie; Myers, Christopher A.; Kammerer, Peter; Unabia, Michelle; Faix, Dennis J.; Blair, Patrick J.] Naval Hlth Res Ctr, Dept Resp Dis Res, San Diego, CA USA. RP Metzgar, D (reprint author), Ibis Biosci, 2251 Faraday Ave,Suite 150, Carlsbad, CA 92008 USA. EM dmetzgar@ibisbio.com RI Valle, Ruben/A-7512-2013 FU Department of Defense (DoD) Global Emerging Infections Surveillance and Response System (GEIS), a Division of the Armed Forces Health Surveillance Center [60501]; Defense Advanced Research Projects Agency (DARPA) FX This work represents NHRC report number 10-22 supported by the Department of Defense (DoD) Global Emerging Infections Surveillance and Response System (GEIS), a Division of the Armed Forces Health Surveillance Center, under research work unit no. 60501. The T5000 Universal Biosensor was developed and provided to NHRC with support from the Defense Advanced Research Projects Agency (DARPA). NR 18 TC 28 Z9 28 U1 0 U2 7 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD NOV PY 2010 VL 48 IS 11 BP 4228 EP 4234 DI 10.1128/JCM.01336-10 PG 7 WC Microbiology SC Microbiology GA 672MK UT WOS:000283588500057 PM 20861338 ER PT J AU Bellitto, VJ Melnik, MI Sorensen, DN Chang, JC AF Bellitto, Victor J. Melnik, Mikhail I. Sorensen, Daniel N. Chang, Joseph C. TI Predicting the shock sensitivity of cyclotrimethylene-trinitramine SO JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY LA English DT Article; Proceedings Paper CT 37th Annual Conference of the North-American-Thermal-Analysis-Society CY SEP 20-23, 2009 CL Lubbock, TX SP N Amer Thermal Anal Soc DE RDX; HMX; Statistical; DSC; AFM; Surface ID RDX AB We studied the surface and thermal properties of seven different varieties of cyclotrimethylene-trinitramine (RDX) crystalline explosives from five manufacturers using differential scanning calorimetry (DSC) and atomic force microscopy (AFM). The specific varieties of the RDX studied were acquired from the previous Reduced Sensitivity RDX Round Robin program. They were chosen because intensive characterization of the materials already existed including shock sensitivity and cyclotetramethylene-tetranitramine (HMX) impurity levels. AFM scans revealed a diversity of surface defects. To quantify the surface defects on the crystalline surface of the RDX particles, surface roughness measurements were acquired. Statistical analysis was undertaken to correlate the observed surface, HMX impurity levels, and DSC thermal curve properties with the known shock sensitivities of the material. It was determined that a statistically significant relationship exists between surface roughness and the shock sensitivity of the material while no relationship was observed between the DSC thermal properties and either surface roughness or shock sensitivity. The HMX content greatly affected the thermal properties of RDX but was uncorrelated with the shock sensitivity. C1 [Bellitto, Victor J.; Sorensen, Daniel N.; Chang, Joseph C.] Naval Surface Warfare Ctr, Indian Head, MD 20640 USA. [Melnik, Mikhail I.] Niagara Univ, Dept Commerce, Niagara, NY 14109 USA. RP Bellitto, VJ (reprint author), Naval Surface Warfare Ctr, 4104 Evans Way,Suite 102, Indian Head, MD 20640 USA. EM victor.bellitto@navy.mil NR 13 TC 4 Z9 5 U1 0 U2 3 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1388-6150 J9 J THERM ANAL CALORIM JI J. Therm. Anal. Calorim. PD NOV PY 2010 VL 102 IS 2 BP 557 EP 562 DI 10.1007/s10973-010-0978-3 PG 6 WC Thermodynamics; Chemistry, Analytical; Chemistry, Physical SC Thermodynamics; Chemistry GA 666DB UT WOS:000283090400021 ER PT J AU Highfill-McRoy, RM Larson, GE Booth-Kewley, S Garland, CF AF Highfill-McRoy, Robyn M. Larson, Gerald E. Booth-Kewley, Stephanie Garland, Cedric F. TI Psychiatric diagnoses and punishment for misconduct: the effects of PTSD in combat-deployed Marines SO BMC PSYCHIATRY LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; VIETNAM VETERANS; INTERPERSONAL VIOLENCE; ANTISOCIAL-BEHAVIOR; TRAUMATIC STRESS; SUBSTANCE USE; WAR; RISK; EXPOSURE AB Background: Research on Vietnam veterans suggests an association between psychological problems, including posttraumatic stress disorder (PTSD), and misconduct; however, this has rarely been studied in veterans of Operation Iraqi Freedom or Operation Enduring Freedom. The objective of this study was to investigate whether psychological problems were associated with three types of misconduct outcomes (demotions, drug-related discharges, and punitive discharges.) Methods: A population-based study was conducted on all U. S. Marines who entered the military between October 1, 2001, and September 30, 2006, and deployed outside of the United States before the end of the study period, September 30, 2007. Demographic, psychiatric, deployment, and personnel information was collected from military records. Cox proportional hazards regression analysis was conducted to investigate associations between the independent variables and the three types of misconduct in war-deployed (n = 77 998) and non-war-deployed (n = 13 944) Marines. Results: Marines in both the war-deployed and non-war-deployed cohorts with a non-PTSD psychiatric diagnosis had an elevated risk for all three misconduct outcomes (hazard ratios ranged from 3.93 to 5.65). PTSD was a significant predictor of drug-related discharges in both the war-deployed and non-war-deployed cohorts. In the war-deployed cohort only, a specific diagnosis of PTSD was associated with an increased risk for both demotions (hazard ratio, 8.60; 95% confidence interval, 6.95 to 10.64) and punitive discharges (HR, 11.06; 95% CI, 8.06 to 15.16). Conclusions: These results provide evidence of an association between PTSD and behavior problems in Marines deployed to war. Moreover, because misconduct can lead to disqualification for some Veterans Administration benefits, personnel with the most serious manifestations of PTSD may face additional barriers to care. C1 [Highfill-McRoy, Robyn M.; Larson, Gerald E.; Booth-Kewley, Stephanie; Garland, Cedric F.] USN, Behav Sci & Epidemiol Program, Hlth Res Ctr, San Diego, CA 92152 USA. [Garland, Cedric F.] Univ Calif San Diego, Dept Family & Prevent Med, San Diego, CA 92103 USA. [Garland, Cedric F.] Univ Calif San Diego, Moores UCSD Canc Ctr, San Diego, CA 92103 USA. RP Highfill-McRoy, RM (reprint author), USN, Behav Sci & Epidemiol Program, Hlth Res Ctr, San Diego, CA 92152 USA. EM Robyn.McRoy@med.navy.mil NR 44 TC 6 Z9 6 U1 0 U2 7 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-244X J9 BMC PSYCHIATRY JI BMC Psychiatry PD OCT 25 PY 2010 VL 10 AR 88 DI 10.1186/1471-244X-10-88 PG 8 WC Psychiatry SC Psychiatry GA 682UZ UT WOS:000284429800001 PM 20974004 ER PT J AU Littman, AJ Boyko, EJ Jacobson, IG Horton, J Gackstetter, GD Smith, B Hooper, T Wells, TS Amoroso, PJ Smith, TC AF Littman, Alyson J. Boyko, Edward J. Jacobson, Isabel G. Horton, Jaime Gackstetter, Gary D. Smith, Besa Hooper, Tomoko Wells, Timothy S. Amoroso, Paul J. Smith, Tyler C. CA Millennium Cohort Study TI Assessing nonresponse bias at follow-up in a large prospective cohort of relatively young and mobile military service members SO BMC MEDICAL RESEARCH METHODOLOGY LA English DT Article ID MILLENNIUM COHORT; US MILITARY; ATTRITION; HEALTH; DEPLOYMENT; POPULATION; PREDICTORS; VACCINATION; DEPRESSION; PREVALENCE AB Background: Nonresponse bias in a longitudinal study could affect the magnitude and direction of measures of association. We identified sociodemographic, behavioral, military, and health-related predictors of response to the first follow-up questionnaire in a large military cohort and assessed the extent to which nonresponse biased measures of association. Methods: Data are from the baseline and first follow-up survey of the Millennium Cohort Study. Seventy-six thousand, seven hundred and seventy-five eligible individuals completed the baseline survey and were presumed alive at the time of follow-up; of these, 54,960 (71.6%) completed the first follow-up survey. Logistic regression models were used to calculate inverse probability weights using propensity scores. Results: Characteristics associated with a greater probability of response included female gender, older age, higher education level, officer rank, active-duty status, and a self-reported history of military exposures. Ever smokers, those with a history of chronic alcohol consumption or a major depressive disorder, and those separated from the military at follow-up had a lower probability of response. Nonresponse to the follow-up questionnaire did not result in appreciable bias; bias was greatest in subgroups with small numbers. Conclusions: These findings suggest that prospective analyses from this cohort are not substantially biased by non-response at the first follow-up assessment. C1 [Littman, Alyson J.; Boyko, Edward J.] Dept Vet Affairs Puget Sound Hlth Care Syst, Seattle Epidemiol Res & Informat Ctr, Seattle, WA USA. [Littman, Alyson J.] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA. [Gackstetter, Gary D.] Analyt Serv INC, Arlington, VA USA. [Jacobson, Isabel G.; Horton, Jaime; Smith, Besa; Wells, Timothy S.; Smith, Tyler C.] USN, Dept Deployment Hlth Res, Hlth Res Ctr, San Diego, CA 92152 USA. [Hooper, Tomoko] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Amoroso, Paul J.] Madigan Army Med Ctr, Ft Lewis, WA USA. RP Littman, AJ (reprint author), Dept Vet Affairs Puget Sound Hlth Care Syst, Seattle Epidemiol Res & Informat Ctr, Seattle, WA USA. EM alyson@u.washington.edu FU U.S. Department of Veterans Affairs, Office of Research and Development; Department of Defense [60002] FX This material is based upon work supported in part by the U.S. Department of Veterans Affairs, Office of Research and Development, Cooperative Studies Program. This work represents report 09.34, supported by the Department of Defense, under work unit no. 60002. The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs, Department of the Navy, Department of the Army, Department of the Air Force, Department of Defense, or the US Government. This research has been conducted in compliance with all applicable federal regulations governing the protection of human subjects in research (Protocol NHRC.2000.007). NR 28 TC 48 Z9 48 U1 1 U2 7 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2288 J9 BMC MED RES METHODOL JI BMC Med. Res. Methodol. PD OCT 21 PY 2010 VL 10 AR 99 DI 10.1186/1471-2288-10-99 PG 11 WC Health Care Sciences & Services SC Health Care Sciences & Services GA 728ZU UT WOS:000287914500001 PM 20964861 ER PT J AU Kelton, ML LeardMann, CA Smith, B Boyko, EJ Hooper, TI Gackstetter, GD Bliese, PD Hoge, CW Smith, TC AF Kelton, Molly L. LeardMann, Cynthia A. Smith, Besa Boyko, Edward J. Hooper, Tomoko I. Gackstetter, Gary D. Bliese, Paul D. Hoge, Charles W. Smith, Tyler C. CA Millennium Cohort Study Team TI Exploratory factor analysis of self-reported symptoms in a large, population-based military cohort SO BMC MEDICAL RESEARCH METHODOLOGY LA English DT Article ID GULF-WAR SYNDROME; POSTTRAUMATIC-STRESS-DISORDER; MILLENNIUM COHORT; US MILITARY; CORRELATION-COEFFICIENT; COMBAT DEPLOYMENT; HEALTH; PREVALENCE; VALIDATION; EXPOSURES AB Background: US military engagements have consistently raised concern over the array of health outcomes experienced by service members postdeployment. Exploratory factor analysis has been used in studies of 1991 Gulf War-related illnesses, and may increase understanding of symptoms and health outcomes associated with current military conflicts in Iraq and Afghanistan. The objective of this study was to use exploratory factor analysis to describe the correlations among numerous physical and psychological symptoms in terms of a smaller number of unobserved variables or factors. Methods: The Millennium Cohort Study collects extensive self-reported health data from a large, population-based military cohort, providing a unique opportunity to investigate the interrelationships of numerous physical and psychological symptoms among US military personnel. This study used data from the Millennium Cohort Study, a large, population-based military cohort. Exploratory factor analysis was used to examine the covariance structure of symptoms reported by approximately 50,000 cohort members during 2004-2006. Analyses incorporated 89 symptoms, including responses to several validated instruments embedded in the questionnaire. Techniques accommodated the categorical and sometimes incomplete nature of the survey data. Results: A 14-factor model accounted for 60 percent of the total variance in symptoms data and included factors related to several physical, psychological, and behavioral constructs. A notable finding was that many factors appeared to load in accordance with symptom co-location within the survey instrument, highlighting the difficulty in disassociating the effects of question content, location, and response format on factor structure. Conclusions: This study demonstrates the potential strengths and weaknesses of exploratory factor analysis to heighten understanding of the complex associations among symptoms. Further research is needed to investigate the relationship between factor analytic results and survey structure, as well as to assess the relationship between factor scores and key exposure variables. C1 [Kelton, Molly L.; LeardMann, Cynthia A.; Smith, Besa; Smith, Tyler C.] US Dept Def, Ctr Deployment Hlth Res, Naval Hlth Res Ctr, San Diego, CA USA. [Boyko, Edward J.] Puget Sound Hlth Care Syst, Vet Affairs, Seattle Epidemiol Res & Informat Ctr, Seattle, WA USA. [Hooper, Tomoko I.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Gackstetter, Gary D.] Analyt Serv Inc, Arlington, VA USA. [Bliese, Paul D.; Hoge, Charles W.] Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD USA. RP LeardMann, CA (reprint author), US Dept Def, Ctr Deployment Hlth Res, Naval Hlth Res Ctr, San Diego, CA USA. EM cynthia.leardmann@med.navy.mil FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland; VA Puget Sound Health Care System; US Department of Defense [60002]; US Army Medical Research and Materiel Command, Fort Detrick, Maryland FX We are indebted to the Millennium Cohort Study participants, without whom these analyses would not be possible. We thank Scott L. Seggerman from the Management Information Division, US Defense Manpower Data Center, Seaside, California. Additionally, we thank Michelle Stoia from the Naval Health Research Center. We also thank all the professionals from the US Army Medical Research and Materiel Command, especially those from the Military Operational Medicine Research Program, Fort Detrick, Maryland. VA Puget Sound Health Care System provided support for Dr. Boyko's involvement in this research. We appreciate the support of the Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland.; This report represents Naval Health Research Center report 09-21, supported by the US Department of Defense, under work unit no. 60002. The views expressed in this article are those of the authors and do not reflect the official policy or position of the US Department of the Navy, US Department of the Army, US Department of the Air Force, US Department of Defense, US Department of Veterans Affairs, or the US Government. This work was supported by the Military Operational Medicine Research Program of the US Army Medical Research and Materiel Command, Fort Detrick, Maryland. The funding organization had no role in the design and conduct of the study; collection, preparation, analysis, or interpretation of data; or preparation, review, or approval of the manuscript. NR 41 TC 4 Z9 4 U1 1 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2288 J9 BMC MED RES METHODOL JI BMC Med. Res. Methodol. PD OCT 15 PY 2010 VL 10 AR 94 DI 10.1186/1471-2288-10-94 PG 11 WC Health Care Sciences & Services SC Health Care Sciences & Services GA 673MQ UT WOS:000283668000001 PM 20950474 ER PT J AU Deyde, VM Sampath, R Garten, RJ Blair, PJ Myers, CA Massire, C Matthews, H Svoboda, P Reed, MS Pohl, J Klimov, AI Gubareva, LV AF Deyde, Varough M. Sampath, Rangarajan Garten, Rebecca J. Blair, Patrick J. Myers, Christopher A. Massire, Christian Matthews, Heather Svoboda, Pavel Reed, Matthew S. Pohl, Jan Klimov, Alexander I. Gubareva, Larisa V. TI Genomic Signature-Based Identification of Influenza A Viruses Using RT-PCR/Electro-Spray Ionization Mass Spectrometry (ESI-MS) Technology SO PLOS ONE LA English DT Article ID ADAMANTANE RESISTANCE; AMANTADINE-RESISTANT; NUCLEIC-ACIDS; H1N1 VIRUS; PCR; INFECTION; HUMANS; REASSORTMENT; EVOLUTION; DIAGNOSIS AB Background: The emergence and rapid spread of the 2009 H1N1 pandemic influenza A virus (H1N1pdm) in humans highlights the importance of enhancing the capability of existing influenza surveillance systems with tools for rapid identification of emerging and re-emerging viruses. One of the new approaches is the RT-PCR electrospray ionization mass spectrometry (RT-PCR/ESI-MS) technology, which is based on analysis of base composition (BC) of RT-PCR amplicons from influenza "core" genes. Combination of the BC signatures represents a "genomic print" of an influenza A virus. Methodology/Principal Findings: Here, 757 samples collected between 2006 and 2009 were tested, including 302 seasonal H1N1, 171 H3N2, 7 swine triple reassortants, and 277 H1N1pdm viruses. Of the 277 H1N1pdm samples, 209 were clinical specimens (throat, nasal and nasopharyngeal swabs, nasal washes, blood and sputum). BC signatures for the clinical specimen from one of the first cases of the 2009 pandemic, A/California/04/2009, confirmed it as an unusual, previously unrecognized influenza A virus, with "core" genes related to viruses of avian, human and swine origins. Subsequent analysis of additional 276 H1N1pdm samples revealed that they shared the genomic print of A/California/04/2009, which differed from those of North American swine triple reassortant viruses, seasonal H1N1 and H3N2 and other viruses tested. Moreover, this assay allowed distinction between "core" genes of co-circulating groups of seasonal H1N1, such as clades 2B, 2C, and their reassortants with dual antiviral resistance to adamantanes and oseltamivir. Conclusions/Significance: The RT-PCR/ESI-MS assay is a broad range influenza identification tool that can be used directly on clinical specimens for rapid and accurate detection of influenza virus genes. The assay differentiates the H1N1pdm from seasonal and other nonhuman hosts viruses. Although not a diagnostic tool, this assay demonstrates its usefulness and robustness in influenza virus surveillance and detection of novel and unusual viruses with previously unseen genomic prints. C1 [Deyde, Varough M.; Garten, Rebecca J.; Klimov, Alexander I.; Gubareva, Larisa V.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Influenza Div, Atlanta, GA 30333 USA. [Blair, Patrick J.; Myers, Christopher A.] USN, Hlth Res Ctr, Naval Resp Dis Lab, San Diego, CA 92152 USA. [Svoboda, Pavel; Reed, Matthew S.; Pohl, Jan] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div Sci Resources, Atlanta, GA USA. [Sampath, Rangarajan; Massire, Christian; Matthews, Heather] Ibis Biosci, Genom & Computat Biol, Carlsbad, CA USA. RP Deyde, VM (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Influenza Div, Atlanta, GA 30333 USA. EM lqg3@cdc.gov FU Centers for Disease Control and Prevention FX The study was funded by the Centers for Disease Control and Prevention. This funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. However, the manuscript was cleared for submission to the journal following CDC's standard operating procedures. RS, CM and HM were involved in data analysis and interpretation. RS was also involved in assay design and preparation of manuscript. All three are full time employees of Abbott Molecular Inc. Abbott Molecular Inc. who funds RS, CM, and HM has therefore a role in the study design, data collection and analysis, and manuscript preparation. NR 45 TC 25 Z9 27 U1 0 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD OCT 12 PY 2010 VL 5 IS 10 AR e13293 DI 10.1371/journal.pone.0013293 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 662KX UT WOS:000282807300018 PM 20967258 ER PT J AU Kirman, CR Albertini, RJ Sweeney, LM Gargas, ML AF Kirman, Christopher R. Albertini, Richard J. Sweeney, Lisa M. Gargas, Michael L. TI 1,3-Butadiene: I. Review of metabolism and the implications to human health risk assessment SO CRITICAL REVIEWS IN TOXICOLOGY LA English DT Review DE 1,3-Butadiene; 1,2-dihydroxy-3; 4-epoxybutane; 1; 3; 4-diepoxybutane; 1; 2-epoxy-3-butene; metabolism; nonlinearity; species differences ID SPRAGUE-DAWLEY RATS; SYNTHETIC RUBBER INDUSTRY; HUMAN LIVER-MICROSOMES; LEVEL INHALATION EXPOSURE; THROUGH PERFUSED LIVERS; HUMAN CYTOCHROME P450S; DNA CROSS-LINKS; SPECIES-DIFFERENCES; BUTADIENE EPOXIDES; HEMOGLOBIN ADDUCTS AB 1,3-Butadiene (BD) is a multisite carcinogen in laboratory rodents following lifetime exposure, with mice demonstrating greater sensitivity than rats. In epidemiology studies of men in the styrene-butadiene rubber industry, leukemia mortality is associated with butadiene exposure, and this association is most pronounced for high-intensity BD exposures. Metabolism is an important determinant of BD carcinogenicity. BD is metabolized to several electrophilic intermediates, including epoxybutene (EB), diepoxybutane (DEB), and epoxybutane diol (EBD), which differ considerably in their genotoxic potency (DEB >> EB > EBD). Important species differences exist with respect to the formation of reactive metabolites and their subsequent detoxification, which underlie observed species differences in sensitivity to the carcinogenic effects of BD. The modes of action for human leukemia and for the observed solid tumors in rodents are both likely related to the genotoxic potencies for one or more of these metabolites. A number of factors related to metabolism can also contribute to nonlinearity in the dose-response relationship, including enzyme induction and inhibition, depletion of tissue glutathione, and saturation of oxidative metabolism. A quantitative risk assessment of BD needs to reflect these species differences and sources of nonlinearity if it is to reflect the current understanding of the disposition of BD. C1 [Kirman, Christopher R.] Summit Toxicol, Orange, VA USA. [Kirman, Christopher R.] Sapphire Grp, Orange, OH USA. [Albertini, Richard J.] Univ Vermont, Coll Med, Dept Pathol, Burlington, VT 05405 USA. [Sweeney, Lisa M.] Toxicol Excellence Risk Assessment, Cincinnati, OH USA. [Gargas, Michael L.] USN, Hlth Res Ctr, Wright Patterson AFB, OH USA. [Sweeney, Lisa M.; Gargas, Michael L.] Sapphire Grp, Dayton, OH USA. RP Kirman, CR (reprint author), Summit Toxicol, 29449 Pike Dr, Orange Village, OH 44022 USA. EM ckirman@summittoxicology.com RI Sweeney, Lisa/K-5114-2012 OI Sweeney, Lisa/0000-0002-4672-7358 FU Sapphire Group, Inc.; Olefins Panel of the American Chemistry Council FX The authors would like to acknowledge the Ms. Leigh Carson for her valuable assistance in preparing the manuscript and the support of Dr. Robert Tardiff of The Sapphire Group, Inc.; This work was funded by the Olefins Panel of the American Chemistry Council. The authors' affiliations are as shown on the first page. The authors have sole responsibility for the writing and content of the paper. Dr. Albertini, Dr. Gargas, Dr. Sweeney, and Mr. Kirman are consultants to the Olefins Panel. NR 67 TC 22 Z9 22 U1 0 U2 10 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1040-8444 J9 CRIT REV TOXICOL JI Crit. Rev. Toxicol. PD OCT PY 2010 VL 40 SU 1 BP 1 EP 11 DI 10.3109/10408444.2010.507181 PG 11 WC Toxicology SC Toxicology GA 661UX UT WOS:000282755000001 PM 20868266 ER PT J AU Albertini, RJ Carson, ML Kirman, CR Gargas, ML AF Albertini, Richard J. Carson, M. Leigh Kirman, Christopher R. Gargas, Michael L. TI 1,3-Butadiene: II. Genotoxicity profile SO CRITICAL REVIEWS IN TOXICOLOGY LA English DT Review DE 1,3-Butadiene; 1,2-dihydroxy-3; 4-epoxybutane; 1,2,3,4-diepoxybutane; 1,2-epoxy-3-butene; genotoxicity; mutagenicity ID SISTER-CHROMATID EXCHANGE; CULTURED HUMAN-LYMPHOCYTES; GLUTATHIONE-S-TRANSFERASE; BIFUNCTIONAL ALKYLATING-AGENTS; DNA CROSS-LINKS; BUTADIENE-POLYMER WORKERS; SYNTHETIC RUBBER INDUSTRY; HPRT MUTANT LYMPHOCYTES; EPOXIDE HYDROLASE GENE; LACI TRANSGENIC MICE AB 1,3-Butadiene's (BD's) major electrophilic metabolites 1,2-epoxy-3-butene (EB), 1,2-dihydroxy-3,4-epoxybutane (EBD), and 1,2,3,4-diepoxybutane (DEB) are responsible for both its mutagenicity and carcinogenicity. EB, EBD, and DEB are DNA reactive, forming a variety of adducts. All three metabolites are genotoxic in vitro and in vivo, with relative mutagenic potencies of DEB >> EB > EBD. DEB also effectively produces gene deletions and chromosome aberrations. BD's greater mutagenicity and carcinogenicity in mice over rats as well as its failure to induce chromosome-level mutations in vivo in rats appear to be due to greater production of DEB in mice. Concentrations of EB and DEB in vivo in humans are even lower than in rats. Although most studies of BD-exposed humans have failed to find increases in gene mutations, one group has reported positive findings. Reasons for these discordant results are examined. BD-related chromosome aberrations have never been demonstrated in humans except for the possible production of micronuclei in lymphocytes of workers exposed to extremely high levels of BD in the workplace. The relative potencies of the BD metabolites, their relative abundance in the different species, and the kinds of mutations they can induce are major considerations in BD's overall genotoxicity profile. C1 [Albertini, Richard J.] Univ Vermont, Coll Med, Dept Pathol, Burlington, VT 05405 USA. [Carson, M. Leigh] Sapphire Grp, Bethesda, MD USA. [Kirman, Christopher R.] Sapphire Grp, Orange, OH USA. [Kirman, Christopher R.] Summit Toxicol, Orange, OH USA. [Gargas, Michael L.] USN, Hlth Res Ctr, Wright Patterson AFB, OH USA. [Gargas, Michael L.] Sapphire Grp, Dayton, OH USA. RP Kirman, CR (reprint author), Summit Toxicol, 29449 Pike Dr, Orange Village, OH 44022 USA. EM ckirman@summittoxicology.com FU Olefins Panel of the American Chemistry Council; Sapphire Group FX This work was funded by the Olefins Panel of the American Chemistry Council. The authors' affiliations are as shown on the first page. The authors have sole responsibility for the writing and content of the paper. Dr. Albertini, Dr. Gargas, Ms. Carson, and Mr. Kirman are consultants to the Olefins Panel.; The authors also would like to acknowledge the support of Dr. Robert Tardiff of The Sapphire Group. NR 355 TC 16 Z9 17 U1 0 U2 9 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1040-8444 J9 CRIT REV TOXICOL JI Crit. Rev. Toxicol. PD OCT PY 2010 VL 40 SU 1 BP 12 EP 73 DI 10.3109/10408444.2010.507182 PG 62 WC Toxicology SC Toxicology GA 661UX UT WOS:000282755000002 PM 20868267 ER PT J AU Kirman, CR Albertini, RA Gargas, ML AF Kirman, Christopher R. Albertini, Richard A. Gargas, Michael L. TI 1,3-Butadiene: III. Assessing carcinogenic modes of action SO CRITICAL REVIEWS IN TOXICOLOGY LA English DT Review DE 1,3-Butadiene; carcinogenicity; 1,2-epoxy-3-butene; 1,2,3,4-diepoxybutane; 1,2-dihydroxy-3; 4-epoxybutane; mode of action ID SYNTHETIC RUBBER INDUSTRY; CANCER-RISK ASSESSMENT; BUTADIENE-POLYMER WORKERS; CHRONIC MYELOID-LEUKEMIA; SPRAGUE-DAWLEY RATS; ABL TYROSINE KINASE; MALE B6C3F1 MICE; CHROMOSOMAL-ABERRATIONS; STYRENE OXIDE; HPRT LOCUS AB 1,3-Butadiene (BD) is a multisite carcinogen in laboratory rodents following lifetime exposure, with greater potency in the mouse than the rat, and is associated with an increase in leukemia mortality in highly exposed workers. Species differences in the formation of reactive metabolites underlie observed species differences in sensitivity to the carcinogenic effects of BD. The modes of action (MOAs) for human leukemia and rodent tumors are both likely related to mutagenic potencies of one or more of these metabolites. However, differences in the nature of genotoxic lesions associated with human leukemia and rodent tumors, along with their implications for risk assessment, require that they be discussed separately. The MOAs for BD are assessed in this review using the modified Hill criteria and human relevance framework. Key events in MOAs for human and rodent cancers are identified, along with important species differences and sources of nonlinearity for each event that can affect extrapolations made from high-to low-dose exposures. Because occupational exposures to BD have also included co-exposures to styrene and dimethyldithiocarbamide (DMDTC), potential interactions with BD carcinogenicity are also discussed. The MOAs for BD carcinogenesis will be used to guide key decisions made in the quantitative cancer dose-response assessment. C1 [Kirman, Christopher R.] Summit Toxicol, Orange, OH USA. [Kirman, Christopher R.] Sapphire Grp, Orange, OH USA. [Albertini, Richard A.] Univ Vermont, Coll Med, Dept Pathol, Burlington, VT 05405 USA. [Gargas, Michael L.] USN, Hlth Res Ctr, Wright Patterson AFB, OH USA. [Gargas, Michael L.] Sapphire Grp, Dayton, OH USA. RP Kirman, CR (reprint author), Summit Toxicol, 29449 Pike Dr, Orange Village, OH 44022 USA. EM ckirman@summittoxicology.com FU Olefins Panel of the American Chemistry Council; Sapphire Group, Inc. FX This work was funded by the Olefins Panel of the American Chemistry Council. The authors' affiliations are as shown on the first page. The authors have sole responsibility for the writing and content of the paper. Dr. Albertini, Dr. Gargas, Dr. Sweeney, and Mr. Kirman are consultants to the Olefins Panel.; The authors would like to acknowledge Ms. Leigh Carson for her valuable assistance in preparing the manuscript and the support of Dr. Robert Tardiff of The Sapphire Group, Inc. NR 120 TC 13 Z9 14 U1 1 U2 6 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1040-8444 J9 CRIT REV TOXICOL JI Crit. Rev. Toxicol. PD OCT PY 2010 VL 40 SU 1 BP 74 EP 92 DI 10.3109/10408444.2010.507183 PG 19 WC Toxicology SC Toxicology GA 661UX UT WOS:000282755000003 PM 20868268 ER PT J AU Bailey, V Carboni, V Eichenberger, C Naff, T Smith, I Warren, T Whitney, B Giri, D Belt, D Brown, D Mazuc, A Seale, T AF Bailey, V. Carboni, V. Eichenberger, C. Naff, T. Smith, I. Warren, T. Whitney, B. Giri, D. Belt, D. Brown, D. Mazuc, A. Seale, T. TI A 6-MV Pulser to Drive Horizontally Polarized EMP Simulators SO IEEE TRANSACTIONS ON PLASMA SCIENCE LA English DT Article DE Antenna; electromagnetic pulser (EMP); fast risetime; horizontal dipole; Marx generator; peaking circuit AB L-3 Pulse Sciences (L-3 PS) is fabricating a 6-MV biconic pulse generator to drive a horizontally polarized dipole electromagnetic pulse simulator antenna [1] at the Naval Air Systems Command, Pax River. The L-3 PS pulser, i.e., the horizontal fast rise electromagnetic pulser (HFREMP), will replace the Maxwell Laboratories ML-5 pulser. The HFREMP project is funded through the Central Test and Evaluation Investment Program (CTEIP). The CTEIP was established by the United States Department of Defense (DoD) to provide joint initiatives, avoid unwarranted duplication of capability, and increase interoperability through capability improvement projects for the DoD Major Ranges and Test Facility Bases. Like the Physics International Fast Risetime EMP Simulator (FEMPS) 2000, which drives an identical antenna at the Centre d'Etudes de Gramat, France, the HFREMP uses two stages of pulse compression. In fact, output capacitors, output switches, intermediate capacitors, and intermediate switches all use the same type of design as the FEMPS 2000. The Marx generator is of a different lower inductance design, and where FEMPS 2000 has a 2.7-MV Marx pulser in only one side, the HFREMP has a 3-MV pulser in each side of the 150-Omega bicone that is the central part of the antenna. When the HFREMP drives the existing Pax River antenna, which is a variable height antenna (30-18 m), it will produce a 60- to 117.5-kV/m peak at the reference sensor with a waveform similar to that of the ML-5, which produces 47-92 kV/m. The HFREMP has also been considered to drive a bounded wave antenna of a different design, which is a fixed height antenna (30 m), producing at the reference sensor a peak field of over 80 kV/m and a wider more smoothly decaying pulse. The design of the HFREMP is described and compared with the designs of ML-5 and FEMPS 2000. Predictions of its performance into both types of antennas are presented. C1 [Bailey, V.; Carboni, V.; Eichenberger, C.; Naff, T.; Smith, I.; Warren, T.; Whitney, B.] L3 Commun Pulse Sci, San Leandro, CA 94577 USA. [Giri, D.] Pro Tech, Alamo, CA 94507 USA. [Belt, D.; Brown, D.; Mazuc, A.; Seale, T.] USN, Naval Air Syst Command, Patuxent River, MD 20670 USA. RP Bailey, V (reprint author), L3 Commun Pulse Sci, San Leandro, CA 94577 USA. NR 5 TC 4 Z9 7 U1 1 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0093-3813 J9 IEEE T PLASMA SCI JI IEEE Trans. Plasma Sci. PD OCT PY 2010 VL 38 IS 10 BP 2554 EP 2558 DI 10.1109/TPS.2010.2065245 PN 1 PG 5 WC Physics, Fluids & Plasmas SC Physics GA 670LE UT WOS:000283422400008 ER PT J AU Pietrzak, RH Goldstein, MB Malley, JC Rivers, AJ Johnson, DC Morgan, CA Southwick, SM AF Pietrzak, Robert H. Goldstein, Marc B. Malley, James C. Rivers, Alison J. Johnson, Douglas C. Morgan, Charles A., III Southwick, Steven M. TI Posttraumatic growth in Veterans of Operations Enduring Freedom and Iraqi Freedom SO JOURNAL OF AFFECTIVE DISORDERS LA English DT Article DE Posttraumatic stress disorder; Trauma; Posttraumatic growth; Veterans; Social support; Psychosocial; Resilience ID TRAUMATIC BRAIN-INJURY; MENTAL-HEALTH PROBLEMS; STRESS-DISORDER; SOCIAL SUPPORT; POSITIVE CHANGE; WAR; RESILIENCE; SYMPTOMS; SURVIVORS; SOLDIERS AB Objective: A growing body of research has examined the prevalence and correlates of psychopathology, mild traumatic brain injury, and related problems in Veterans of Operations Enduring Freedom and Iraqi Freedom (OEF-OIF). While these studies help characterize the deleterious effects of combat, no known study has examined factors that may enhance posttraumatic growth or positive changes experienced as a result of combat in this population. Method: A total of 272 predominantly older Reservist/National Guard OEF-OIF Veterans completed an anonymous mail survey that assessed combat exposure, psychopathology, psychosocial functioning, social support, and posttraumatic growth. Results: Seventy-two percent of the sample endorsed a significant degree of posttraumatic growth in at least one of the areas assessed, the most common of which were changing priorities about what is important in life (52.2%), being able to better appreciate each day (51.1%), and being better able to handle difficulties (48.5%). Hierarchical regression analysis revealed that younger age, greater posttraumatic stress disorder (PTSD) symptoms, and increased perceptions of unit member support and effort/perseverance were significantly associated with posttraumatic growth. Respondents with PTSD scored higher on an overall measure of posttraumatic growth and on items reflecting appreciation of life and personal strength. Limitations: This study is limited by a relatively low survey return rate and employment of an abbreviated measure of posttraumatic growth. Conclusions: Results of this study suggest that interventions to bolster unit member support and to enhance perceptions of effort and perseverance may help promote posttraumatic growth in OEF-OIF Veterans. (C) 2010 Elsevier B.V. All rights reserved. C1 [Pietrzak, Robert H.; Rivers, Alison J.; Morgan, Charles A., III; Southwick, Steven M.] Yale Univ, Sch Med, Dept Psychiat, West Haven, CT 06516 USA. [Pietrzak, Robert H.; Rivers, Alison J.; Morgan, Charles A., III; Southwick, Steven M.] VA Connecticut Healthcare Syst, Resilience Lab, Natl Ctr Posttraumat Stress Disorder, West Haven, CT USA. [Goldstein, Marc B.] Cent Connecticut State Univ, Dept Psychol, New Britain, CT 06050 USA. [Malley, James C.] Cent Connecticut State Univ, Dept Counseling & Family Therapy, New Britain, CT 06050 USA. [Johnson, Douglas C.] Univ Calif San Diego, Sch Med, Naval Hlth Res Ctr, San Diego, CA 92103 USA. [Johnson, Douglas C.] Univ Calif San Diego, Sch Med, Dept Psychiat, San Diego, CA 92103 USA. RP Pietrzak, RH (reprint author), Yale Univ, Sch Med, Dept Psychiat, 950 Campbell Ave 151E, West Haven, CT 06516 USA. EM robert.pietrzak@yale.edu FU State of Connecticut; Department of Mental Health and Addiction Services; National Center for PTSD FX We thank the veterans who participated in this survey. We appreciate the assistance of the Center for Public Policy and Social Research at Central Connecticut State University and the Connecticut Department of Veterans' Affairs in conducting this research. This work was supported by grants from the State of Connecticut, the Department of Mental Health and Addiction Services, the National Center for PTSD, and a private gift. NR 45 TC 31 Z9 32 U1 1 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-0327 J9 J AFFECT DISORDERS JI J. Affect. Disord. PD OCT PY 2010 VL 126 IS 1-2 BP 230 EP 235 DI 10.1016/j.jad.2010.03.021 PG 6 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 658KD UT WOS:000282488000029 PM 20399504 ER PT J AU Anders, MW Andersen, ME Clewell, HJ Gargas, ML Guengerich, FP Reitz, RH AF Anders, M. W. Andersen, Melvin E. Clewell, Harvey J., III Gargas, Michael L. Guengerich, F. Peter Reitz, Richard H. TI Comment on MV Evans and JC Caldwell: Evaluation of two different metabolic hypotheses for dichloromethane toxicity using physiologically based pharmacokinetic modeling of in vivo gas uptake data exposure in female B6C3F1 mice, Toxicol. Appl. Pharmacol., 244,280-290,2010 SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Letter ID RELEVANCE; CHLORIDE; CYP2A6 C1 [Clewell, Harvey J., III] Hamner Inst Hlth Sci, Ctr Human Hlth Assessment, Res Triangle Pk, NC 27709 USA. [Anders, M. W.] Univ Rochester, Med Ctr, Dept Anesthesiol, Rochester, NY 14642 USA. [Anders, M. W.] Univ Rochester, Med Ctr, Dept Environm Med, Rochester, NY 14642 USA. [Anders, M. W.] Univ Rochester, Med Ctr, Dept Physiol & Pharmacol, Rochester, NY 14642 USA. [Andersen, Melvin E.] Hamner Inst Hlth Sci, Program Chem Safety Sci, Res Triangle Pk, NC 27709 USA. [Gargas, Michael L.] USN, Hlth Res Ctr, Environm Hlth Effects Lab, Wright Patterson AFB, OH 45433 USA. [Guengerich, F. Peter] Vanderbilt Univ, Sch Med, Dept Biochem, Nashville, TN 37232 USA. [Guengerich, F. Peter] Vanderbilt Univ, Sch Med, Ctr Mol Toxicol, Nashville, TN 37232 USA. [Reitz, Richard H.] RHR Toxicol Consulting, Midland, MI 48640 USA. RP Clewell, HJ (reprint author), Hamner Inst Hlth Sci, Ctr Human Hlth Assessment, 6 Davis Dr,POB 12137, Res Triangle Pk, NC 27709 USA. EM hclewell@theHamner.org NR 9 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0041-008X J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD OCT 1 PY 2010 VL 248 IS 1 BP 63 EP 64 DI 10.1016/j.taap.2010.07.012 PG 2 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 652HS UT WOS:000281995100008 PM 20655322 ER PT J AU Cambrea, LR Davis, MC Groshens, TJ Guenthner, AJ Lamison, KR Mabry, JM AF Cambrea, Lee R. Davis, Matthew C. Groshens, Thomas J. Guenthner, Andrew J. Lamison, Kevin R. Mabry, Joseph M. TI A New Room-Temperature Liquid, High-Performance Tricyanate Ester SO JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY LA English DT Article DE cyclopolymerization; differential scanning calorimetry; high performance polymers; thermosets ID CYANATE ESTER; RESIN; ENAMINONES; 1,3,5-TRIAROYLBENZENES; COMPOSITES; POLYMERS; SCALE AB A new tricyanate ester monomer of a tris(4-hydroxyphenyl) benzene derivative was synthesized in 6-steps with a 63% overall yield. The geminal substitution of phenyl rings on ethane, in addition to the creation of a racemic/diastereomeric mixture, resulted in a liquid monomer whereas compounds with similar structure and symmetry have melting points typically over 100 degrees C. Key properties of the polycyanurate, such as the glass transition temperature and moisture resistance, were positively influenced by the higher crosslink density provided by the monomer. (C) 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 4547-4554, 2010 C1 [Cambrea, Lee R.; Davis, Matthew C.; Groshens, Thomas J.] USN, Air Warfare Ctr, Michelson Lab, Chem & Mat Div, China Lake, CA 93555 USA. [Guenthner, Andrew J.; Lamison, Kevin R.; Mabry, Joseph M.] USAF, Res Lab, Prop Directorate, Edwards AFB, CA 93525 USA. RP Davis, MC (reprint author), USN, Air Warfare Ctr, Michelson Lab, Chem & Mat Div, China Lake, CA 93555 USA. EM matthew.davis@navy.mil FU In-house Laboratory Independent Research award from the Office of Naval Research; Air Force Office of Scientific Research FX Financial support through an In-house Laboratory Independent Research award from the Office of Naval Research, and funding from the Air Force Office of Scientific Research, is gratefully acknowledged. Thanks to Dan Bliss (NAWCWD) for assistance with thermogravimetric analyses. NR 32 TC 13 Z9 13 U1 0 U2 5 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0887-624X J9 J POLYM SCI POL CHEM JI J. Polym. Sci. Pol. Chem. PD SEP 15 PY 2010 VL 48 IS 20 BP 4547 EP 4554 DI 10.1002/pola.24246 PG 8 WC Polymer Science SC Polymer Science GA 662VE UT WOS:000282841400021 ER PT J AU Booth-Kewley, S Larson, GE Highfill-McRoy, RM Garland, CF Gaskin, TA AF Booth-Kewley, Stephanie Larson, Gerald E. Highfill-McRoy, Robyn M. Garland, Cedric F. Gaskin, Thomas A. TI Factors Associated With Antisocial Behavior in Combat Veterans SO AGGRESSIVE BEHAVIOR LA English DT Article DE antisocial behavior; post-traumatic stress disorder; combat deployment; mental health ID POSTTRAUMATIC-STRESS-DISORDER; TRAUMATIC BRAIN-INJURY; WAR ZONE STRESSORS; VIETNAM VETERANS; MENTAL-HEALTH; INTERNALIZING SUBTYPES; SYMPTOMS; IRAQ; DEPLOYMENT; EXPOSURE AB The objective of this study was to identify factors associated with antisocial behavior in 1,543 Marines who deployed to combat zones in support of conflicts in Iraq and Afghanistan during 2002-2007. Five factors were associated with antisocial behavior in multivariate analyses: post-traumatic stress disorder (PTSD) symptoms, deployment-related stressors, combat exposure, younger age, and being divorced. PTSD symptoms had a stronger association with antisocial behavior than any other variable. A unique and important finding of this study was the association between deployment-related stressors and a higher incidence of antisocial behavior. Because deployment-related stressors are potentially modifiable, the military may be able to address them in concrete ways such as by shortening deployments and improving communication with home. Aggr. Behav. 36:330-337, 2010. Published 2010 by Wiley-Liss, Inc.(dagger) C1 [Booth-Kewley, Stephanie] USN, Hlth Res Ctr, Behav Sci & Epidemiol Dept, San Diego, CA 92106 USA. [Garland, Cedric F.] Univ Calif San Diego, Dept Family & Prevent Med, San Diego, CA 92103 USA. [Garland, Cedric F.] Moores UCSD Canc Ctr, La Jolla, CA USA. [Gaskin, Thomas A.] US Marine Corps, Combat Operat Stress Control, Headquarters, Quantico, VA USA. RP Booth-Kewley, S (reprint author), USN, Hlth Res Ctr, Behav Sci & Epidemiol Dept, 140 Sylvester Rd, San Diego, CA 92106 USA. EM stephanie.kewley@med.navy.mil FU Headquarters, Marine Corps (Combat Operational Stress Control) FX Grant sponsor: Headquarters, Marine Corps (Combat Operational Stress Control).; This study was funded by Headquarters, Marine Corps (Combat Operational Stress Control), under Work Unit 60518 at Naval Health Research Center. NR 30 TC 18 Z9 18 U1 1 U2 7 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0096-140X J9 AGGRESSIVE BEHAV JI Aggressive Behav. PD SEP-OCT PY 2010 VL 36 IS 5 BP 330 EP 337 DI 10.1002/ab.20355 PG 8 WC Behavioral Sciences; Psychology, Multidisciplinary SC Behavioral Sciences; Psychology GA 641MS UT WOS:000281131500006 PM 20626042 ER PT J AU Knapik, JJ Trone, DW Swedler, DI Villasenor, A Bullock, SH Schmied, E Bockelman, T Han, P Jones, BH AF Knapik, Joseph J. Trone, Daniel W. Swedler, David I. Villasenor, Adriana Bullock, Steve H. Schmied, Emily Bockelman, Timothy Han, Peggy Jones, Bruce H. TI Injury Reduction Effectiveness of Assigning Running Shoes Based on Plantar Shape in Marine Corps Basic Training SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE physical fitness; physical activity; tobacco use; prior injury; demographics; menstrual dysfunction ID LOWER-EXTREMITY INJURY; MEDICAL SURVEILLANCE; US NAVY; MILITARY; EPIDEMIOLOGY; PREVENTION; RECOMMENDATIONS; RECRUITS; RATES; ARMY AB Background: Shoe manufacturers market motion control, stability, and cushioned shoes for plantar shapes defined as low, normal, and high, respectively. This assignment procedure is presumed to reduce injuries by compensating for differences in running mechanics. Hypothesis: Assigning running shoes based on plantar shape will not reduce injury risk in Marine Corps basic training. Study Design: Randomized controlled clinical trial; Level of evidence, 1. Methods: After foot examinations, Marine Corps recruits in an experimental group (E: 408 men, 314 women) were provided motion control, stability, or cushioned shoes for plantar shapes indicative of low, medium, or high arches, respectively. A control group (C: 432 men, 257 women) received a stability shoe regardless of plantar shape. Injuries during the 12 weeks of training were determined from outpatient visits obtained from the Defense Medical Surveillance System. Other known injury risk factors (eg, fitness, smoking, prior physical activity) were obtained from a questionnaire, existing databases, or the training units. Results: Cox regression indicated little difference in injury risk between the E and C groups among men (hazard ratio [E/C] = 1.01; 95% confidence interval, 0.82-1.24) or women (hazard ratio [E/C] = 0.88; 95% confidence interval, 0.70-1.10). Conclusion: This prospective study demonstrated that assigning shoes based on the shape of the plantar foot surface had little influence on injuries even after considering other injury risk factors. C1 [Knapik, Joseph J.; Bullock, Steve H.; Jones, Bruce H.] USA, Directorate Epidemiol & Dis Surveillance, Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. [Trone, Daniel W.; Villasenor, Adriana; Schmied, Emily; Han, Peggy] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Swedler, David I.] Johns Hopkins Univ, Baltimore, MD USA. [Bockelman, Timothy] Marine Corps Recruit Depot, Parris Isl, SC USA. RP Knapik, JJ (reprint author), USA, Directorate Epidemiol & Dis Surveillance, Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. EM joseph.knapik@us.army.mil FU Naval Health Research Center, Work Unit [60626] FX This research was supported by the Naval Health Research Center, Work Unit No. 60626. We express our appreciation to the following members of our research team from the Naval Health Research Center in San Diego, California: Carol Macera, Mitchell Rauh, and Richard Shaffer. Additional thanks are due to James Reading from MCRD, San Diego, California. NR 31 TC 35 Z9 35 U1 1 U2 9 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD SEP PY 2010 VL 38 IS 9 BP 1759 EP 1767 DI 10.1177/0363546510369548 PG 9 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 644ZD UT WOS:000281419800003 PM 20576837 ER PT J AU Taller, J Wisbach, G Bertucci, W AF Taller, Janos Wisbach, Gordon Bertucci, William TI Single-incision laparoscopic sleeve gastrectomy for morbid obesity: video technique and review of first 10 patients SO SURGERY FOR OBESITY AND RELATED DISEASES LA English DT Editorial Material C1 [Taller, Janos; Wisbach, Gordon; Bertucci, William] Naval Med Center, Dept Gen Surg, San Diego, CA USA. RP Taller, J (reprint author), Pacific Bariatr Surg Med Group, 4060 4th Ave,Suite 330, San Diego, CA 92103 USA. NR 2 TC 4 Z9 4 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1550-7289 J9 SURG OBES RELAT DIS JI Surg. Obes. Relat. Dis. PD SEP-OCT PY 2010 VL 6 IS 5 BP 559 EP 560 DI 10.1016/j.soard.2010.07.007 PG 2 WC Surgery SC Surgery GA 660VB UT WOS:000282673400024 PM 20870188 ER PT J AU Seto, J Walsh, MP Metzgar, D Seto, D AF Seto, Jason Walsh, Michael P. Metzgar, David Seto, Donald TI Computational analysis of adenovirus serotype 5 (HAdV-C5) from an HAdV coinfection shows genome stability after 45 years of circulation SO VIROLOGY LA English DT Article DE Adenovirus evolution; Coinfection; Genome stability; Viral bioinformatics; Viral genomics; Sequencing error ID ACUTE RESPIRATORY-DISEASE; EPIDEMIC KERATOCONJUNCTIVITIS; MOLECULAR EPIDEMIOLOGY; BIOINFORMATICS ANALYSIS; ANTIGENIC RELATIONSHIPS; VECTOR DEVELOPMENT; MILITARY RECRUITS; CROSSOVER SITES; AIDS PATIENT; GENE-THERAPY AB Adenovirus coinfections present opportunities for genome recombination. Computational analysis of an HAdV-C5 field strain genome, recovered from a patient with acute respiratory disease and coinfected with HAdV-B21, shows that there was no exchange of genomic material into HAdV-C5. Comparison of this genome to the sparsely amplified prototype demonstrates a high level of sequence conservation and stability of this genome across 45 years. Further, comparison to a version of the prototype that had been passaged in laboratory settings shows stability as well. HAdV genome stability and evolution are considerations for applications as vaccines and as vectors for gene delivery. In the annotation analysis, a single sequencing error in the HAdV-C5_ARM (Adenovirus Reference Material) genome is noted and may lead to erroneous annotation and biological interpretations. (C) 2010 Elsevier Inc. All rights reserved. C1 [Seto, Jason; Walsh, Michael P.; Seto, Donald] George Mason Univ, Dept Bioinformat & Computat Biol, Manassas, VA 20110 USA. [Metzgar, David] Naval Hlth Res Ctr, Dept Resp Dis Res, San Diego, CA 92106 USA. RP Seto, D (reprint author), George Mason Univ, Dept Bioinformat & Computat Biol, 10900 Univ Blvd,MSN 5B3, Manassas, VA 20110 USA. EM jseto@gmu.edu; mwalsh5@gmu.edu; david.metzgar@med.navy.mil; dseto@gmu.edu FU US Army Medical Research and Material Command (USAMRMC) [DAMD17-03-2-0089]; EOS; HQ USAF Surgeon General Office, Directorate of Modernization (SGR); Defense Threat Reduction Agency (DTRA); NHRC [7151] FX We thank Clark Tibbetts for initial discussions and for providing the impetus and opportunity to pursue this line of research. Anjan Purkayastha, James M. Clark, and Kevin Russell provided appreciated preliminary analyses and discussions. During the collection of the genome data and preliminary data analyses, DS (2002-2004), AP (2003-2005), JMC (2004), and CT (2001-2005) were affiliated with the HQ USAF Surgeon General Office, Directorate of Modernization (SGR) and the Epidemic Outbreak Surveillance (EOS) Program, 5201 Leesburg Pike, Suite 1401, Falls Church, VA 22041. Portions of this work were funded, during these time periods, by a grant from the US Army Medical Research and Material Command (USAMRMC; DAMD17-03-2-0089) and additional support was through the EOS Project, funded by HQ USAF Surgeon General Office, Directorate of Modernization (SGR) and the Defense Threat Reduction Agency (DTRA). Therefore, it is noted that the opinions and assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the views of the US Department of Defense.; NHRC 7151 was collected with the support of the Global Emerging Infections Surveillance and Response System (GEIS), a Division of the Armed Forces Health Surveillance Center, Silver Spring, MD (www. afhsc.mil). NR 68 TC 6 Z9 6 U1 0 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD SEP 1 PY 2010 VL 404 IS 2 BP 180 EP 186 DI 10.1016/j.virol.2010.05.010 PG 7 WC Virology SC Virology GA 629OP UT WOS:000280209800005 PM 20627349 ER PT J AU Houng, HSH Gong, HP Kajon, AE Jones, MS Kuschner, RA Lyons, A Lott, L Lin, KH Metzgar, D AF Houng, Huo-Shu H. Gong, Heping Kajon, Adriana E. Jones, Morris S. Kuschner, Robert A. Lyons, Arthur Lott, Lisa Lin, Kuei-Hsiang Metzgar, David TI Genome sequences of Human Adenovirus 14 isolates from mild respiratory cases and a fatal pneumonia, isolated during 2006-2007 epidemics in North America SO RESPIRATORY RESEARCH LA English DT Article ID MILITARY RECRUITS; INFECTIONS; DISEASE; TYPE-7; ILLNESS; SEROTYPES; EVOLUTION; CHILDREN; TAIWAN; CAMP AB Background: Human adenovirus 14 (HAdV-14) is a recognized causative agent of epidemic febrile respiratory illness (FRI). Last reported in Eurasia in 1963, this virus has since been conspicuously absent in broad surveys, and was never isolated in North America despite inclusion of specific tests for this serotype in surveillance methods. In 2006 and 2007, this virus suddenly emerged in North America, causing high attack rate epidemics of FRI and, in some cases, severe pneumonias and occasional fatalities. Some outbreaks have been relatively mild, with low rates of progression beyond uncomplicated FRI, while other outbreaks have involved high rates of more serious outcomes. Methodology and Findings: In this paper we present the complete genomic sequence of this emerging pathogen, and compare genomic sequences of isolates from both mild and severe outbreaks. We also compare the genome sequences of the recent isolates with those of the prototype HAdV-14 that circulated in Eurasia 30 years ago and the closely related sequence of HAdV-11a, which has been circulating in southeast Asia. Conclusions: The data suggest that the currently circulating strain of HAdV-14 is closely related to the historically recognized prototype throughout its genome, though it does display a couple of potentially functional mutations in the fiber knob and E1A genes. There are no polymorphisms that suggest an obvious explanation for the divergence in severity between outbreak events, suggesting that differences in outcome are more likely environmental or host determined rather than viral genetics. C1 [Houng, Huo-Shu H.; Gong, Heping; Kuschner, Robert A.; Lyons, Arthur] Walter Reed Army Inst Res, Div Viral Dis, Silver Spring, MD 20910 USA. [Kajon, Adriana E.] Lovelace Resp Res Inst, Program Infect Dis, Albuquerque, NM 87108 USA. [Jones, Morris S.] David Grant USAF Med Ctr DGMC, Clin Invest Facil, Travis AFB, CA 94535 USA. [Lott, Lisa] Off AF Surg Gen, Adv Diagnost Lab, Lackland AFB, TX 78236 USA. [Lin, Kuei-Hsiang] Kaohsiung Med Univ, Dept Clin Lab, Kaohsiung 80708, Taiwan. [Metzgar, David] USN, Hlth Res Ctr, Dept Resp Dis Res, San Diego, CA 92106 USA. RP Houng, HSH (reprint author), Walter Reed Army Inst Res, Div Viral Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM huo-shu.houng@amedd.army.mil RI Lyons, Arthur/B-8923-2011; Valle, Ruben/A-7512-2013 NR 40 TC 17 Z9 17 U1 0 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1465-9921 J9 RESP RES JI Respir. Res. PD AUG 25 PY 2010 VL 11 AR 116 DI 10.1186/1465-9921-11-116 PG 8 WC Respiratory System SC Respiratory System GA 659FP UT WOS:000282552700001 PM 20738863 ER PT J AU Kovaleski, KJ Matzdorf, CA Nickerson, WC AF Kovaleski, Kevin J. Matzdorf, Craig A. Nickerson, William C. TI Assessment of accelerated corrosion tests compared to beachfront testing and proposed evaluation method of coated panels SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Kovaleski, Kevin J.; Matzdorf, Craig A.; Nickerson, William C.] NAVAIR, Mat Engn Div, Patuxent River, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 2010 VL 240 MA 104-PMSE PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V20UK UT WOS:000208164706309 ER PT J AU Feng, SM AF Feng, Simin TI Graphical retrieval method for orthorhombic anisotropic materials SO OPTICS EXPRESS LA English DT Article ID NEGATIVE-INDEX; METAMATERIALS; REFRACTION AB We apply the equivalent theory to orthorhombic anisotropic materials and provide a general unit-cell design criterion for achieving a length-independent retrieval of the effective material parameters from a single layer of unit cells. We introduce a graphical retrieval method and phase unwrapping techniques. The graphical method utilizes the linear regression technique. Our method can reduce the uncertainty of experimental measurements and the ambiguity of phase unwrapping. Moreover, the graphical method can simultaneously determine the bulk values of the six effective material parameters, permittivity and permeability tensors, from a single layer of unit cells. C1 USN, Air Warfare Ctr, Res & Intelligence Dept, Phys Branch, China Lake, CA 93555 USA. RP Feng, SM (reprint author), USN, Air Warfare Ctr, Res & Intelligence Dept, Phys Branch, China Lake, CA 93555 USA. EM simin.feng@navy.mil FU NAVAIR; Office of Naval Research FX The author thanks NAVAIR's ILIR program and the program managers Mark Spector and Steven Russell in Office of Naval Research for funding of this work. NR 18 TC 8 Z9 8 U1 1 U2 4 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD AUG 2 PY 2010 VL 18 IS 16 BP 17009 EP 17019 DI 10.1364/OE.18.017009 PG 11 WC Optics SC Optics GA 640IB UT WOS:000281042400075 PM 20721089 ER PT J AU Mohr, SB Garland, FC Garland, CF Gorham, ED Ricordi, C AF Mohr, Sharif B. Garland, Frank C. Garland, Cedric F. Gorham, Edward D. Ricordi, Camillo TI Is There a Role of Vitamin D Deficiency in Type 1 Diabetes of Children? SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Letter ID FINNISH CHILDREN; RISK; CHILDHOOD; MELLITUS; COHORT C1 [Mohr, Sharif B.; Garland, Frank C.; Garland, Cedric F.; Gorham, Edward D.] Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA. [Mohr, Sharif B.; Garland, Frank C.; Gorham, Edward D.] Naval Hlth Res Ctr, San Diego, CA USA. [Ricordi, Camillo] Univ Miami, Diabet Res Inst, Miami, FL USA. RP Garland, CF (reprint author), Univ Calif San Diego, Dept Family & Prevent Med, 9500 Gilman Dr,0631C, La Jolla, CA 92093 USA. EM cgarland@ucsd.edu OI Ricordi, Camillo/0000-0001-8092-7153 NR 7 TC 10 Z9 10 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD AUG PY 2010 VL 39 IS 2 BP 189 EP 190 DI 10.1016/j.amepre.2010.03.023 PG 2 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 632MP UT WOS:000280429100012 PM 20621268 ER PT J AU Boyko, EJ Jacobson, IG Smith, B Ryan, MAK Hoofer, TI Amoroso, PJ Gackstetter, GD Barrett-Connor, E Smith, TC AF Boyko, Edward J. Jacobson, Isabel G. Smith, Besa Ryan, Margaret A. K. Hoofer, Tomoko I. Amoroso, Paul J. Gackstetter, Gary D. Barrett-Connor, Elizabeth Smith, Tyler C. CA Millennium Cohort Study Team TI Risk of Diabetes in US Military Service Members in Relation to Combat Deployment and Mental Health SO DIABETES CARE LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; INSULIN-RESISTANCE; PRIMARY-CARE; DEPRESSION; PERFORMANCE; CHECKLIST; VETERANS; MELLITUS; ADULTS; SPAN AB OBJECTIVE Few prospective data exist on the risk of diabetes in individuals serving in the U.S. military. The objectives of this study were to determine whether military deployment, combat exposures, and mental health conditions were related to the risk of newly reported diabetes over 3 years. RESEARCH DESIGN AND METHODS Data were from Millennium Cohort Study participants who completed baseline (July 2001-June 2003) and follow-up (June 2004-February 2006) questionnaires (follow-up response rate = 71.4%). After exclusion criteria were applied, adjusted analyses included 44,754 participants (median age 36 years, range 18-68 years). Survey instruments collected demographics, height, weight, lifestyle, military service, clinician-diagnosed diabetes, and other physical and mental health conditions. Deployment was defined by U.S. Department of Defense databases, and combat exposure was assessed by self-report at follow-up. Odds of newly reported diabetes were estimated using logistic regression analysis. RESULTS Occurrence of diabetes during follow-up was 3 per 1,000 person-years. Individuals reporting diabetes at follow-up were significantly older, had greater baseline BMI, and were less likely to be Caucasian. After adjustment for age, sex, BMI, education, race/ethnicity, military service characteristics, and mental health conditions, only baseline posttraumatic stress disorder (PTSD) was significantly associated with risk of diabetes (odds ratio 2.07 [95% Cl 1.31-3.29]). Deployments since September 2001 were not significantly related to higher diabetes risk, with or without combat exposure. CONCLUSIONS In this military cohort, PTSD symptoms at baseline but not other mental health symptoms or military deployment experience were significantly associated with future risk of self-reported diabetes. C1 [Boyko, Edward J.] Puget Sound Hlth Care Syst, Dept Vet Affairs, Seattle Epidemiol Res & Informat Ctr, Seattle, WA USA. [Jacobson, Isabel G.; Smith, Tyler C.] USN, Hlth Res Ctr, Dept Deployment Hlth Res, San Diego, CA 92152 USA. [Smith, Besa; Ryan, Margaret A. K.] USN, Hosp Camp Pendleton, Camp Pendleton, CA USA. [Hoofer, Tomoko I.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Amoroso, Paul J.] Madigan Army Med Ctr, Tacoma, WA 98431 USA. [Gackstetter, Gary D.] Analyt Serv Inc ANSER, Arlington, VA USA. [Barrett-Connor, Elizabeth] Univ Calif San Diego, Div Epidemiol Family & Prevent Med, San Diego, CA 92103 USA. RP Boyko, EJ (reprint author), Puget Sound Hlth Care Syst, Dept Vet Affairs, Seattle Epidemiol Res & Informat Ctr, Seattle, WA USA. EM eboyko@uw.edu FU U.S. Department of Defense [60002]; U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland; Department of Veterans Affairs; Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland FX w This represents report 09-35, supported by the U.S. Department of Defense, under work unit no. 60002. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of Veterans Affairs, Department of the Navy, Department of the Army, Department of the Air Force, Department of Defense, or the U.S. Government. This research has been conducted in compliance with all applicable federal regulations governing the protection of human subjects in research (protocol NHRC.2000.0007). The funding organization had no role in the design and conduct of the study; collection, analysis, or preparation of data; or preparation, review, or approval of the manuscript.; The Millennium Cohort Study is funded through the Military Operational Medicine Research Program of the U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland. The Department of Veterans Affairs supported E.J.B.'s involvement with this research.; We are indebted to the Millennium Cohort Study participants, without whom these analyses would not be possible. We thank Scott L. Seggerman from the Management Information Division, Defense Manpower Data Center, Seaside, California. In addition, we thank Melissa Bagnell, MPH, Gina Creaven, MBA, James Davies, Lacy Farnell, Nisara Granado, MPH, PhD, Gia Gumbs, MPH, Jaime Horton, Cynthia LeardMann, MPH, Travis Leleu, Jamie McGrew, Amanda Pietrucha, MPH, Teresa Powell, MS, Amber Seelig, MPH, Katherine Snell, Steven Speigle, Kari Welch, MA, Martin White, MPH, James Whitmer, and Charlene Wong, MPH, from the Department of Defense Center for Deployment Health Research, Naval Health Research Center, San Diego, California, and Michelle Stoia, also from the Naval Health Research Center. We also thank the professionals from the U.S. Army Medical Research and Materiel Command, especially those from the Military Operational Medicine Research Program, Fort Detrick, Maryland. We appreciate the support of the Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland. These individuals provided assistance as part of their official duties as employees of the Department of Defense, and none received additional financial compensation. NR 26 TC 54 Z9 55 U1 1 U2 4 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA SN 0149-5992 J9 DIABETES CARE JI Diabetes Care PD AUG PY 2010 VL 33 IS 8 BP 1771 EP 1777 DI 10.2337/dc10-0296 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 645AF UT WOS:000281422600016 PM 20484134 ER PT J AU Prevey, PS Jayaraman, N Ravindranath, RA Shepard, M AF Prevey, Paul S. Jayaraman, N. Ravindranath, Ravi A. Shepard, Michael TI Mitigation of Fretting Fatigue Damage in Blade and Disk Pressure Faces With Low Plasticity Burnishing SO JOURNAL OF ENGINEERING FOR GAS TURBINES AND POWER-TRANSACTIONS OF THE ASME LA English DT Article ID SURFACE MODIFICATION; STRESS; TI-6AL-4V AB Low plasticity burnishing (LPB) is now established as a surface enhancement technology capable of introducing through-thickness compressive residual stresses in the edges of gas turbine engine blades and vanes to mitigate foreign object damage (FOD). The "fatigue design diagram" (FDD) method has been described and demonstrated to determine the depth and magnitude of compression required to achieve the optimum high cycle fatigue strength, and to mitigate a given depth of damage characterized by the fatigue stress concentration factor, k(f). LPB surface treatment technology and the FDD method have been combined to successfully mitigate a wide variety of surface damage ranging from FOD to corrosion pits in titanium and steel gas turbine engine compressor and fan components. LPB mitigation of fretting-induced damage in Ti-6Al-4V in laboratory samples has now been extended to fan and compressor components. LPB tooling technology recently developed to allow the processing of the pressure faces of fan and compressor blade dovetails and mating disk slots is described. Fretting-induced microcracks that form at the pressure face edge of bedding on both the blade dovetail and the dovetail disk slots in Ti-6-4 compressor components can now be arrested by the introduction of deep stable compression in conventional computer numerical control (CNC) machine tools during manufacture or overhaul. The compressive residual stress field design method employing the FDD approach developed at Lambda Technologies is described in application to mitigate fretting damage. The depth and magnitude of compression and the fatigue and damage tolerance achieved are presented. It was found that microcracks as deep as 0.030 in. (0.75 mm) large enough to be readily detected by current nondestructive inspection (NDI) technology can be fully arrested by LPB. The depth of compression achieved could allow NDI screening followed by LPB processing of critical components to reliably restore fatigue performance and extend component life. C1 [Prevey, Paul S.; Jayaraman, N.] Lambda Technol, Cincinnati, OH 45227 USA. [Ravindranath, Ravi A.] NAVAIR, Patuxent River, MD 20670 USA. [Shepard, Michael] WPAFB AFRL MLLMN, Wright Patterson AFB, OH 45433 USA. RP Prevey, PS (reprint author), Lambda Technol, 3929 Virginia Ave, Cincinnati, OH 45227 USA. EM pprevey@lambdatechs.com; njayaraman@lambdatechs.com; ravi.ravindranath@navy.mil; michael.shepard@wpafb.af.mil NR 36 TC 0 Z9 0 U1 1 U2 16 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0742-4795 J9 J ENG GAS TURB POWER JI J. Eng. Gas. Turbines Power-Trans. ASME PD AUG PY 2010 VL 132 IS 8 AR 082105 DI 10.1115/1.2943154 PG 8 WC Engineering, Mechanical SC Engineering GA 603BF UT WOS:000278182200008 ER PT J AU Vyas, KJ Patel, GR Shukla, D Mathews, WC AF Vyas, Kartavya J. Patel, Gulab R. Shukla, Deepak Mathews, William C. TI A comparison in HIV-associated stigma among healthcare workers in urban and rural Gujarat SO SAHARA J-JOURNAL OF SOCIAL ASPECTS OF HIV-AIDS LA English DT Article DE Stigma; healthcare workers; HIV-positive patients; India ID SEXUALLY-TRANSMITTED INFECTIONS; SEX WORKERS; INDIA; EPIDEMIC; HIV/AIDS AB The present study measures levels of stigma within health care settings in urban and rural Gujarat, in an attempt to understand how this may have contributed to the state's increasing HIV incidence. Two sites were studied: a rural hospital in Bardoli and an urban hospital in Surat. HIV-associated stigma among healthcare workers (N = 170) was assessed using a Stigma Index. Overall, analyses suggest an increase in medical education was found to be associated with higher stigmatisation (p < 0.001). Furthermore, a statistically significant difference between stigma scores of HCWs in rural and urban Gujarat was not observed. C1 [Vyas, Kartavya J.] Naval Med Ctr, San Diego NMCSD, San Diego, CA USA. [Patel, Gulab R.] New Civil Hosp, Dept Surg, Surat, Gujarat, India. [Shukla, Deepak] Surat New Civil Hosp, ART Therapy Ctr, Surat, India. EM kvyas@ucsd.edu RI Mathews, William/E-4451-2010 OI Mathews, William/0000-0002-2352-0725 NR 13 TC 4 Z9 4 U1 0 U2 2 PU SA MEDICAL ASSOC HEALTH & MEDICAL PUBL GROUP PI CLAREMONT PA 21 DREYER ST, 4TH FLOOR, SANCLARE BLDG, CLAREMONT, 7700, SOUTH AFRICA SN 1729-0376 J9 SAHARA J-J SOC ASP H JI Sahara J-J. Soc. Asp. HIV/AIDS PD AUG PY 2010 VL 7 IS 2 BP 71 EP 75 PG 5 WC Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA 643FP UT WOS:000281281300004 PM 21409297 ER PT J AU May, CA Cipriani, D Lorenz, KA AF May, Courtney A. Cipriani, Daniel Lorenz, Kent A. TI Power Development Through Complex Training for The Division I Collegiate Athlete SO STRENGTH AND CONDITIONING JOURNAL LA English DT Article DE power development; complex training; power; weightlifting ID VERTICAL JUMP PERFORMANCE; PROFESSIONAL RUGBY PLAYERS; BIOMECHANICAL ANALYSIS; KINETIC-ANALYSIS; REST INTERVAL; BODY POWER; RECOVERY; ABILITY; OUTPUT; MUSCLE AB Sports requiring explosive movements require power production. A strength and conditioning program should consist of exercises that will promote power development in the athlete. Power can be defined as the product of a force and velocity, which can be trained and increased through resisted and plyometric movements. Complex training can be used in force development and yields an increase in power. The published literature on complex training does not necessarily reflect the practices of complex training in the weight room. This article's purpose is to compare the suggestions from the literature and strength and conditioning coaches in a practical setting. C1 [May, Courtney A.] USN, Hlth Res Ctr, Warfighter Performance Dept, San Diego, CA 92152 USA. [Cipriani, Daniel; Lorenz, Kent A.] San Diego State Univ, Sch Exercise & Nutr Sci, Dept Exercise & Nutr Sci, San Diego, CA 92182 USA. RP May, CA (reprint author), USN, Hlth Res Ctr, Warfighter Performance Dept, San Diego, CA 92152 USA. NR 25 TC 6 Z9 6 U1 0 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1524-1602 J9 STRENGTH COND J JI Strength Cond. J. PD AUG PY 2010 VL 32 IS 4 BP 30 EP 43 DI 10.1519/SSC.0b013e3181dd8f47 PG 14 WC Sport Sciences SC Sport Sciences GA 633CC UT WOS:000280476100002 ER PT J AU LeardMann, CA Smith, B Ryan, MAK AF LeardMann, Cynthia A. Smith, Besa Ryan, Margaret A. K. TI Do adverse childhood experiences increase the risk of postdeployment posttraumatic stress disorder in US Marines? SO BMC PUBLIC HEALTH LA English DT Article ID MENTAL-HEALTH PROBLEMS; MALE VIETNAM VETERANS; HOUSEHOLD DYSFUNCTION; NATIONAL SAMPLE; PTSD SYMPTOMS; COMBAT; ABUSE; MILITARY; ASSOCIATION; DEPLOYMENT AB Background: Posttraumatic stress disorder ( PTSD) has been associated with combat intensity, lack of social support, and adverse childhood factors among military personnel in previous studies. It has not been well established if adverse childhood experiences reported predeployment are independently associated with postdeployment PTSD. Methods: Data were evaluated from 8,391 male responders of the Recruit Assessment Program survey at Marine Corps Recruit Depot in San Diego who were deployed in support of military conflicts between September 2001 and June 2004. Using patient medical records to determine PTSD diagnoses, Cox proportional hazard modeling was performed to examine if adverse childhood experiences were independently associated with postdeployment PTSD. Results: After adjustment, those who reported adverse childhood experiences in more than one category were significantly more likely to be diagnosed with postdeployment PTSD. Specifically, childhood physical neglect was mostly strongly associated with postdeployment PTSD. Conclusions: Findings suggest that Marines who experience multiple types of adverse childhood experiences may be at increased risk for postdeployment PTSD. It is possible, however, that these results indicate that men willing to report childhood adverse experiences are also more willing to seek care for PTSD. C1 [LeardMann, Cynthia A.; Smith, Besa; Ryan, Margaret A. K.] USN, US Dept Def, Ctr Deployment Hlth Res, Hlth Res Ctr, San Diego, CA 92152 USA. RP LeardMann, CA (reprint author), USN, US Dept Def, Ctr Deployment Hlth Res, Hlth Res Ctr, San Diego, CA 92152 USA. EM cynthia.leardmann@med.navy.mil FU Department of Defense [60002] FX This work represents report 09 05, supported by the Department of Defense, under work unit no. 60002. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of Defense, nor the US Government. The funding organization had no role in the design and conduct of the study; collection, analysis, or preparation of data; or preparation, review, or approval of the manuscript. NR 41 TC 23 Z9 25 U1 2 U2 12 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD JUL 26 PY 2010 VL 10 AR 437 DI 10.1186/1471-2458-10-437 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 650QB UT WOS:000281863500002 PM 20659342 ER PT J AU Abi-Salloum, TY Henry, B Davis, JP Narducci, FA AF Abi-Salloum, T. Y. Henry, B. Davis, J. P. Narducci, F. A. TI Resonances and excitation pathways in four-level N-scheme atomic systems SO PHYSICAL REVIEW A LA English DT Article ID ELECTROMAGNETICALLY INDUCED TRANSPARENCY AB In this work, we theoretically study the absorption and dispersion coefficients of a probe field in four-level N-scheme atomic systems driven by two additional fields. We separate the steady-state solution of the appropriate density matrix element into the sum of three resonances. The effect of each resonance on the overall absorption and dispersion experienced by the probe is studied as a function of the strengths of the two other fields. In the limit of low saturation, we reveal the physics of these resonances and associate them with atomic excitation pathways, which we explicitly explain in the bare-states picture. C1 [Abi-Salloum, T. Y.; Henry, B.] Widener Univ, Dept Phys & Astron, Chester, PA 19013 USA. [Davis, J. P.; Narducci, F. A.] Naval Air Syst Command, EO Sensors Div, Patuxent River, MD 20670 USA. RP Abi-Salloum, TY (reprint author), Widener Univ, Dept Phys & Astron, Chester, PA 19013 USA. FU Office of Naval Research FX Two of us (J.P.D and F.A.N) gratefully acknowledge financial support from an In-House Laboratory Innovative Research (ILIR) grant from the Office of Naval Research. NR 20 TC 11 Z9 11 U1 0 U2 4 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD JUL 26 PY 2010 VL 82 IS 1 AR 013834 DI 10.1103/PhysRevA.82.013834 PG 6 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA 630SC UT WOS:000280292700022 ER PT J AU Nordt, SP Chen, J Clark, R AF Nordt, S. P. Chen, J. Clark, R. TI Severe Hypermagnesemia from Acute Epsom Salt Administration SO CLINICAL TOXICOLOGY LA English DT Meeting Abstract C1 [Nordt, S. P.] Univ So Calif, Los Angeles, CA USA. [Chen, J.] Naval Hosp Balboa, San Diego, CA USA. [Clark, R.] Univ Calif San Diego, San Diego, CA 92103 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INFORMA HEALTHCARE PI NEW YORK PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA SN 1556-3650 J9 CLIN TOXICOL JI Clin. Toxicol. PD JUL PY 2010 VL 48 IS 6 MA 238 BP 653 EP 653 PG 1 WC Toxicology SC Toxicology GA 671HY UT WOS:000283492900256 ER PT J AU Enright, MP Chan, KS Moody, JP Golden, PJ Chandra, R Pentz, AC AF Enright, Michael P. Chan, Kwai S. Moody, Jonathan P. Golden, Patrick J. Chandra, Ramesh Pentz, Alan C. TI Probabilistic Fretting Fatigue Assessment of Aircraft Engine Disks SO JOURNAL OF ENGINEERING FOR GAS TURBINES AND POWER-TRANSACTIONS OF THE ASME LA English DT Article DE aerospace engines; aircraft; fatigue cracks; finite element analysis; fracture mechanics; gas turbines; inspection; integral equations; probability; stress analysis; wear ID HIGH-CYCLE FATIGUE; FRACTURE-MECHANICS APPROACH; DESIGN METHODOLOGY; CONTACT FATIGUE; PREDICTION; NOTCH AB Fretting fatigue is a random process that continues to be a major source of damage associated with the failure of aircraft gas turbine engine components. Fretting fatigue is dominated by the fatigue crack growth phase and is strongly dependent on the magnitude of the stress values in the contact region. These stress values often have the most influence on small cracks where traditional long-crack fracture mechanics may not apply. A number of random variables can be used to model the uncertainty associated with the fatigue crack growth process. However, these variables can often be reduced to a few primary random variables related to the size and location of the initial crack, variability associated with applied stress and crack growth life models, and uncertainty in the quality and frequency of nondeterministic inspections. In this paper, an approach is presented for estimating the risk reduction associated with the nondestructive inspection of aircraft engine components subjected to fretting fatigue. Contact stress values in the blade attachment region are estimated using a fine mesh finite element model coupled with a singular integral equation solver and combined with bulk stress values to obtain the total stress gradient at the edge of contact. This stress gradient is applied to the crack growth life prediction of a mode I fretting fatigue crack. A probabilistic model of the fretting process is formulated and calibrated using failure data from an existing engine fleet. The resulting calibrated model is used to quantify the influence of inspection on the probability of fracture of an actual military engine disk under real life loading conditions. The results can be applied to quantitative risk predictions of gas turbine engine components subjected to fretting fatigue. C1 [Enright, Michael P.; Chan, Kwai S.; Moody, Jonathan P.] SW Res Inst, San Antonio, TX 78238 USA. [Golden, Patrick J.] Air Force Res Lab, Wright Patterson AFB, OH 45433 USA. [Chandra, Ramesh; Pentz, Alan C.] NAVAIR, Patuxent River, MD 20670 USA. RP Enright, MP (reprint author), SW Res Inst, San Antonio, TX 78238 USA. FU NAVAIR [EDO-08-SA-0021]; Air Force Research Laboratory/Major Shared Resource Center (AFRL/MSRC) FX This work was supported by NAVAIR under Agreement No. EDO-08-SA-0021. The authors wish to acknowledge Dr. Sam Naboulsi for performing the fine mesh finite element computations at the Air Force Research Laboratory/Major Shared Resource Center (AFRL/MSRC) at Wright-Patterson AFB. NR 33 TC 0 Z9 3 U1 2 U2 21 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0742-4795 J9 J ENG GAS TURB POWER JI J. Eng. Gas. Turbines Power-Trans. ASME PD JUL PY 2010 VL 132 IS 7 AR 072502 DI 10.1115/1.4000130 PG 9 WC Engineering, Mechanical SC Engineering GA 588NY UT WOS:000277079800010 ER PT J AU Mohr, SB Garland, CF Gorham, ED Grant, WB Garland, FC AF Mohr, Sharif B. Garland, Cedric F. Gorham, Edward D. Grant, William B. Garland, Frank C. TI Ultraviolet B Irradiance and Vitamin D Status are Inversely Associated With Incidence Rates of Pancreatic Cancer Worldwide SO PANCREAS LA English DT Article DE pancreatic neoplasms; incidence; vitamin D; alcohol; smoking; multiple regression ID MORTALITY-RATES; GEOGRAPHIC-VARIATION; SOLAR-RADIATION; OVARIAN-CANCER; UNITED-STATES; 107 COUNTRIES; COLON CANCER; RISK-FACTORS; BREAST; SUNLIGHT AB Objectives: To determine if an inverse association exits between latitude, ultraviolet B (UVB) irradiance and incidence rates of pancreatic cancer worldwide. Methods: Multiple linear regression was used to investigate the relationship and between UVB irradiance incidence rates of pancreatic cancer and while controlling for cigarette, alcohol and sugar consumption, and proportion overweight. Serum 25-hydroxyvitamin D [25(OH) D] levels were estimated, and their association with incidence rates also was analyzed. Results: Incidence rates were higher at higher latitudes (R(2) for latitude for men, 0.51; P < 0.001; R(2) for latitude for women, 0.32; P < 0.001). Ultraviolet B irradiance also was independently inversely associated with incidence in men (P < 0.01) and women (P = 0.02). Alcohol (P < 0.0001) and cigarette (P <= 0.01) consumption were positively associated with incidence in men (R(2) for overall model for men, 0.76; P < 0.0001). Alcohol (P < 0.0001) and sugar (P = 0.001) consumption were positively associated with incidence rates in women (R(2) for overall model for women, 0.64; P < 0.0001). Incidence rates were half as high in countries with estimated serum 25(OH) >30 ng/mL (75 nmol/L) than in those with <= 30 ng/mL. Conclusions: Countries with lower UVB irradiance had higher incidence rates of pancreatic cancer in both hemispheres, with occasional exceptions. C1 [Garland, Cedric F.] Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA. [Mohr, Sharif B.; Gorham, Edward D.; Garland, Frank C.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Grant, William B.] Sunlight Nutr & Hlth Res Ctr, San Francisco, CA USA. RP Garland, CF (reprint author), Univ Calif San Diego, Dept Family & Prevent Med, 0631C,9500 Gilman Dr, La Jolla, CA 92093 USA. EM cgarland@ucsd.edu RI Grant, William/B-8311-2009 OI Grant, William/0000-0002-1439-3285 FU Penn State Hershey Cancer Institute of the Milton S. Hershey Medical Center, Hershey, Pennsylvania, through the Naval Health Research Center; Bureau of Medicine and Surgery, Department of the Navy [60126] FX This research was supported by a Congressional allocation to the Penn State Hershey Cancer Institute of the Milton S. Hershey Medical Center, Hershey, Pennsylvania, through the Naval Health Research Center and the Bureau of Medicine and Surgery, Department of the Navy, under Work Unit No. 60126. NR 54 TC 20 Z9 20 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0885-3177 J9 PANCREAS JI Pancreas PD JUL PY 2010 VL 39 IS 5 BP 669 EP 674 DI 10.1097/MPA.0b013e3181ce654d PG 6 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 612RD UT WOS:000278919100020 PM 20442683 ER PT J AU Metzgar, D McDonough, EA Hansen, CJ Blaesing, CR Baynes, D Hawksworth, AW Blair, PJ Faix, DJ Russell, KL AF Metzgar, David McDonough, Erin A. Hansen, Christian J. Blaesing, Carl R. Baynes, Darcie Hawksworth, Anthony W. Blair, Patrick J. Faix, Dennis J. Russell, Kevin L. TI Local changes in rates of group A Streptococcus disease and antibiotic resistance are associated with geographically widespread strain turnover events SO VIRULENCE LA English DT Article DE microbial drug resistance; ecology; epidemiology; molecular epidemiology; streptococcal M protein; streptococcal infections; Streptococcus pyogenes; virulence ID ACUTE RHEUMATIC-FEVER; UNITED-STATES; EPIDEMIOLOGY; INFECTIONS; PENICILLIN; SEROTYPES; SURVEILLANCE; PHARYNGITIS AB This study addresses the effects of dynamic strain turnover and antibiotic prophylaxis on rates of group A Streptococcus (GAS) antibiotic resistance and disease. The authors analyzed the strain distributions, disease rates and patterns of antibiotic resistance of 802 GAS isolates collected from 2002 through 2007. These samples were collected from patients with GAS infection symptoms at ten military facilities. Macrolide resistance peaked at 25% during 2004, due to the geographically widespread dominance of a single resistant strain (M75). The resistant strain was not retained regardless of local patterns of macrolide use, and resistance rates decreased upon replacement of M75 with macrolide-susceptible strains. Disease rates were similarly correlated with dominance of specific M types. Statistical analysis revealed temporal correlations between strain distributions at multiple locations. Only the most common strains yielded enough data at multiple sites for statistically significant comparison of temporal fluctuations in dominance, but these (including M44, M3, M18, M118 and M6) all yielded highly significant temporal correlations of 90% or greater on yearly scales. As expected given the complexity and variability of strain distributions on shorter time scales, analysis on a monthly scale yielded lower degrees of positive correlation (31-62%), but in this case all significant correlations were still positive. Shifts in antibiotic resistance profiles and disease rates at specific sites appear to be associated with strain replacements happening on larger scales, independent of antibiotic use at individual sites. C1 [Metzgar, David; McDonough, Erin A.; Hansen, Christian J.; Baynes, Darcie; Hawksworth, Anthony W.; Blair, Patrick J.; Faix, Dennis J.; Russell, Kevin L.] USN, Hlth Res Ctr, Dept Resp Dis Res, San Diego, CA 92152 USA. [Blaesing, Carl R.] USN Hosp, Beaufort, SC USA. [Russell, Kevin L.] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD USA. RP Metzgar, D (reprint author), USN, Hlth Res Ctr, Dept Resp Dis Res, San Diego, CA 92152 USA. EM davidleemetzgar@yahoo.com RI Valle, Ruben/A-7512-2013; Blaesing, Carl/D-5077-2017 OI Blaesing, Carl/0000-0002-2465-5058 NR 24 TC 8 Z9 8 U1 0 U2 3 PU LANDES BIOSCIENCE PI AUSTIN PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA SN 2150-5594 J9 VIRULENCE JI Virulence PD JUL-AUG PY 2010 VL 1 IS 4 BP 247 EP 253 DI 10.4161/viru.1.4.11979 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 789MW UT WOS:000292520600005 PM 21178449 ER PT J AU Phillips, CJ LeardMann, CA Gumbs, GR Smith, B AF Phillips, Christopher J. LeardMann, Cynthia A. Gumbs, Gia R. Smith, Besa TI Risk Factors for Posttraumatic Stress Disorder Among Deployed US Male Marines SO BMC PSYCHIATRY LA English DT Article ID MALE VIETNAM VETERANS; GULF-WAR VETERANS; ADVERSE CHILDHOOD EXPERIENCES; MENTAL-HEALTH PROBLEMS; NATIONAL SAMPLE; SOCIAL SUPPORT; LIFE EVENTS; PSYCHOLOGICAL DISTRESS; HOUSEHOLD DYSFUNCTION; LONGITUDINAL ANALYSIS AB Background: Combat exposure has been reported as one of the strongest risk factors for postdeployment posttraumatic stress disorder (PTSD) among military service members. Determining the impact of specific deployment-related exposures on the risk of developing PTSD has not been fully explored. Our study objective was to explore the relationship between specific combat exposures and other life experiences with postdeployment PTSD. Methods: This study consisted of male Marines who completed a Recruit Assessment Program (RAP) survey during recruit training at the Marine Corps Recruit Depot in San Diego, California as well as a follow-up survey several years after recruit training. Study participants included those Marines who deployed to the current operations in Iraq or Afghanistan between the baseline and follow-up surveys. Multivariable logistic regression was performed to determine which significant exposures and experiences were associated with postdeployment PTSD. Results: Of the 706 study participants, 10.8% screened positive for postdeployment PTSD. Those who reported feeling in great danger of death (odds ratio [OR] = 4.63, 95% confidence interval [CI]: 2.46-8.73), were shot or seriously injured (OR = 3.51, 95% CI: 1.58-7.77), saw someone wounded or killed (OR = 2.47, 95% CI: 1.08-5.67), and baseline (before recruit training) prior violence exposures (OR = 2.99, 95% CI: 1.46-6.10) were at increased odds for reporting PTSD symptoms. Number of deployments, number of close friends or relatives reported at follow-up, and enlisted pay grade were also significantly associated with postdeployment PTSD. Conclusions: Combat exposures, specifically the threat of death, serious injury, and witnessing injury or death are significant risk factors for screening positive for postdeployment PTSD among male Marines as well as violence exposures prior to entering the Marine Corps, which are independent of future combat exposures. A thorough history of lifetime violence exposures should be pursued when considering a clinical diagnosis of PTSD. C1 [Phillips, Christopher J.; LeardMann, Cynthia A.; Gumbs, Gia R.; Smith, Besa] USN, Dept Def Ctr Deployment Hlth Res, Hlth Res Ctr, Dept 164, San Diego, CA 92106 USA. RP Phillips, CJ (reprint author), USN, Dept Def Ctr Deployment Hlth Res, Hlth Res Ctr, Dept 164, 140 Sylvester Rd, San Diego, CA 92106 USA. EM chris.phillips@med.navy.mil FU Henry M Jackson Foundation for the Advancement of Military Medicine, Rockville, MD FX We are indebted to the Marine recruit study participants and our support staff at the Marine Corps Recruiting Depot, San Diego. We also thank Steven Speigle and James Whitmer from the Department of Defense Center for Deployment Health Research; Michelle Stoia, from the Naval Health Research Center, San Diego, CA. We value the insight generously provided by both Iris-Tatjana Kolassa and LinChiat Chang, and appreciate the support of the Henry M Jackson Foundation for the Advancement of Military Medicine, Rockville, MD. NR 53 TC 40 Z9 42 U1 4 U2 22 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-244X J9 BMC PSYCHIATRY JI BMC Psychiatry PD JUN 25 PY 2010 VL 10 AR 52 DI 10.1186/1471-244X-10-52 PG 11 WC Psychiatry SC Psychiatry GA 637UC UT WOS:000280843200001 PM 20579379 ER PT J AU Roberts, MJ Feng, SM Moran, M Johnson, L AF Roberts, M. Joseph Feng, Simin Moran, Mark Johnson, Linda TI Effective permittivity near zero in nanolaminates of silver and amorphous polycarbonate SO JOURNAL OF NANOPHOTONICS LA English DT Article DE Thin film devices and applications ID METAMATERIALS; LIGHT AB Experiments were conducted to demonstrate a material with epsilon near zero (ENZ). Dimensions estimated by effective medium theory guided the fabrication of nanolaminate composites of silver and amorphous polycarbonate. This approach ensures that the ordinary component (not the extraordinary component) of the relative permittivity of a uniaxial material equals zero. The nanolaminates were characterized for optical properties using spectroscopic ellipsometry, reflectance, and transmittance. Simulations using both, a new scattering retrieval method, and an effective-medium approximation (EMA) were compared to the experimental results. These results indicate that nanolaminates should enable further exploration into the new optical phenomena predicted for ENZ materials. C1 [Roberts, M. Joseph; Feng, Simin; Moran, Mark; Johnson, Linda] USN, Air Warfare Ctr, Weap Div, Res & Intelligence Dept, China Lake, CA 93555 USA. RP Roberts, MJ (reprint author), USN, Air Warfare Ctr, Weap Div, Res & Intelligence Dept, China Lake, CA 93555 USA. EM joe.roberts@navy.mil; simin.feng@navy.mil FU Office of Naval Research FX The authors thank the Office of Naval Research for support of this work through the ILIR program and program manager Scott Munro. We thank Don Bowling for a close reading of the manuscript. NR 15 TC 12 Z9 12 U1 0 U2 8 PU SPIE-SOC PHOTOPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 1934-2608 J9 J NANOPHOTONICS JI J. Nanophotonics PD JUN 22 PY 2010 VL 4 AR 043511 DI 10.1117/1.3463420 PG 7 WC Nanoscience & Nanotechnology; Optics SC Science & Technology - Other Topics; Optics GA 704PA UT WOS:000286063700001 ER PT J AU Cochenour, B Mullen, L Muth, J AF Cochenour, Brandon Mullen, Linda Muth, John TI Effect of scattering albedo on attenuation and polarization of light underwater SO OPTICS LETTERS LA English DT Article ID LINKS AB Recent work on underwater laser communication links uses polarization discrimination to improve system performance [Appl. Opt. 48, 328 (2009)] [in Proceedings of IEEE Oceans 2009 (IEEE, 2009), pp. 1-4]. In the laboratory, Maalox antacid is commonly used as a scattering agent. While its scattering function closely mimics that of natural seawaters, its scattering albedo can be much higher, as Maalox particles tend to be less absorbing. We present a series of experiments where Nigrosin dye is added to Maalox in order to more accurately recreate real-world absorption and scattering properties. We consider the effect that scattering albedo has on received power and the degree of depolarization of forward-scattered light in the context of underwater laser communication links. C1 [Cochenour, Brandon; Mullen, Linda] Naval Air Syst Command, Electroopt & Special Mission Sensors Div, Patuxent River, MD 20670 USA. [Cochenour, Brandon; Muth, John] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27606 USA. RP Cochenour, B (reprint author), Naval Air Syst Command, Electroopt & Special Mission Sensors Div, 22347 Cedar Point Rd, Patuxent River, MD 20670 USA. EM brandon.cochenour@navy.mil RI Muth, John/E-9027-2012 OI Muth, John/0000-0002-2488-7721 FU Science, Mathematics & Research for Transformation (SMART) Scholarship; National Science Foundation (NSF) [CCS-0636603] FX This work is supported by the Science, Mathematics & Research for Transformation (SMART) Scholarship and the National Science Foundation (NSF) grant CCS-0636603. NR 10 TC 21 Z9 22 U1 1 U2 12 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD JUN 15 PY 2010 VL 35 IS 12 BP 2088 EP 2090 PG 3 WC Optics SC Optics GA 619NB UT WOS:000279435800054 PM 20548395 ER PT J AU Jones, K Granado, N Smith, B Slymen, D Ryan, M Boyko, E Gackstetter, G Smith, T AF Jones, K. Granado, N. Smith, B. Slymen, D. Ryan, M. Boyko, E. Gackstetter, G. Smith, T. TI ARE NEWLY-REPORTED LUPUS AND RHEUMATOID ARTHRITIS ASSOCIATED WITH US MILITARY DEPLOYMENT IN SUPPORT OF THE OPERATIONS IN IRAQ AND AFGHANISTAN? SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 43rd Annual Meeting of the Society-for-Epidemiologic-Research CY JUN 23-26, 2010 CL Anaheim, SOLOMON ISLANDS SP Soc Epidemiol Res C1 [Jones, K.; Granado, N.; Smith, B.; Slymen, D.; Ryan, M.; Boyko, E.; Gackstetter, G.; Smith, T.] Naval Hlth Res Ctr, San Diego, CA 92106 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 2010 VL 171 SU 11 BP S86 EP S86 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 603QO UT WOS:000278223300345 ER PT J AU Pietrucha, A Granado, NS Smith, B Boyko, E Ryan, M Hooper, T Smith, TC AF Pietrucha, A. Granado, N. S. Smith, B. Boyko, E. Ryan, M. Hooper, T. Smith, T. C. TI A LONGITUDINAL STUDY OF BACK PAIN IN US MILITARY PERSONNEL DEPLOYED IN SUPPORT OF OPERATIONS IN IRAQ AND AFGHANISTAN; THE MILLENNIUM COHORT STUDY SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 43rd Annual Meeting of the Society-for-Epidemiologic-Research CY JUN 23-26, 2010 CL Anaheim, SOLOMON ISLANDS SP Soc Epidemiol Res C1 [Pietrucha, A.; Granado, N. S.; Smith, B.; Boyko, E.; Ryan, M.; Hooper, T.; Smith, T. C.] Naval Hlth Res Ctr, San Diego, CA 92106 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 2010 VL 171 SU 11 BP S87 EP S87 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 603QO UT WOS:000278223300346 ER PT J AU McClellan, SF Olde, BA Freeman, DH Mann, WF Rotruck, JR AF McClellan, Scott F. Olde, Brent A. Freeman, Daniel H. Mann, William F. Rotruck, John R. TI Smokeless Tobacco Use Among Military Flight Personnel: A Survey of 543 Aviators SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE snuff; smokeless tobacco; chewing tobacco; spit tobacco; dental health-based tobacco cessation programs ID CESSATION INTERVENTION; DENTAL OFFICE; SPIT TOBACCO; PREVALENCE; CLINICS; PROGRAM AB MCCLELLAN SF, OLDE BA, FREEMAN DH, MANN WF, ROTRUCK JR. Smokeless tobacco use among military flight personnel: a survey of 543 aviators. Aviat Space Environ Med 2010; 81:575-80. Introduction: Although there has been a steady decline in smoking rates among adults in the United States in recent years, the consumption of smokeless tobacco (ST) continues to increase. Moreover, ST use in the U.S. military is far higher than in the general population. This study was designed to determine the extent of ST use in a military aviation population and measure users' attitudes toward elements of a proposed cessation program. Methods: A study was conducted at two naval aviation training wings in western Florida. The target population (N = 2233) included flight instructors, students, and staff/support personnel who were rated aviators or flight officers. A total of 543 usable questionnaires were returned, yielding a response rate of 24.3%. Results: There were 71 respondents who reported using ST in the last 30 d (13.1%). This group responded favorably to questions regarding the involvement of both medical and dental health professionals as critical components of an effective ST cessation program. Discussion: This survey provides evidence for a rate of ST use among military aviators that is much higher than the U.S. national civilian average of 3.5%. Drawing upon the background of previous dental health-based studies, we propose augmenting existing tobacco cessation resources by creating separate ST cessation programs to reduce ST use among U.S. military aviators. C1 [McClellan, Scott F.] Madigan Army Med Ctr Ophthalmol Clin, Ft Lewis, WA USA. [Olde, Brent A.] USN, Air Warfare Ctr, Div Aircraft, Patuxent River, MD USA. [Freeman, Daniel H.] Univ Texas Med Branch, Dept Prevent Med & Community Hlth, Galveston, TX USA. [Mann, William F.] USN, Inst Aviat Med, Pensacola, FL USA. [Rotruck, John R.] Natl Naval Med Ctr, Dept Anesthesiol, Bethesda, MD USA. USN, Aerosp Med Inst, Pensacola Naval Air Stn, Pensacola, FL USA. RP McClellan, SF (reprint author), 1314 Foreman Rd, Dupont, WA 98327 USA. EM scott.f.mcclellan@us.army.mil NR 20 TC 2 Z9 2 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD JUN PY 2010 VL 81 IS 6 BP 575 EP 580 DI 10.3357/ASEM.2317.2010 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 604VA UT WOS:000278305400007 PM 20540449 ER PT J AU Washington, C Metzgar, D Hazbon, MH Binn, L Lyons, A Coward, C Kuschner, R AF Washington, Cicely Metzgar, David Hazbon, Manzour Hernando Binn, Leonard Lyons, Arthur Coward, Carl Kuschner, Robert TI Multiplexed Luminex xMAP Assay for Detection and Identification of Five Adenovirus Serotypes Associated with Epidemics of Respiratory Disease in Adults SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID REAL-TIME PCR; US MILITARY RECRUITS; YOUNG-ADULTS; INFECTIONS; COINFECTIONS; EMERGENCE; HEALTHY; ILLNESS; PANEL AB Several serotypes of human adenovirus (HAdV) cause acute respiratory disease (ARD) among healthy adults, sometimes generating broad outbreaks with high attack rates and occasional fatalities. Timely serotype identification provides valuable epidemiological information and significantly contributes to prevention (vaccination) strategies. The prevalence of specific serotypes causing ARD varies geographically. HAdV-3, HAdV-4, HAdV-7, HAdV-14, and HAdV-21 are the serotypes most commonly found in adult populations in the Western Hemisphere. Unfortunately, conventional serotype identification is a tedious process which can take a week or longer. For this reason, new molecular methods for serotype identification are needed. Commercially available rapid antigen and PCR assays for the detection of HAdV are universal but do not distinguish between the different serotypes. We describe the development of a sensitive and specific multiplex assay capable of identifying serotypes 3, 4, 7, 14, and 21. Two sets of primers were used for nonspecific (universal) PCR amplification, and serotype-specific probes coupled to Luminex tags were used for target-specific extension (TSE). PCR and TSE primers were designed using known hexon gene sequences of HAdV. The TSE products of HAdV-3, HAdV-4, HAdV-7, HAdV-14, and HAdV-21 were correctly identified using the Luminex xMAP fluid microsphere-based array system. No cross-reactivity with other respiratory pathogens or other HAdV serotypes was observed. This multiplexed assay can be expanded to include more serotypes and will allow broad and rapid detection and identification of adenoviral serotypes in a high-throughput environment. C1 [Washington, Cicely; Hazbon, Manzour Hernando; Binn, Leonard; Lyons, Arthur; Coward, Carl; Kuschner, Robert] Walter Reed Army Inst Res, Div Viral Dis, Silver Spring, MD 20910 USA. [Metzgar, David] USN, Hlth Res Ctr, Dept Resp Dis Res, San Diego, CA 92152 USA. RP Washington, C (reprint author), 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Cicely.Washington@us.army.mil RI Lyons, Arthur/B-8923-2011 FU Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center under WRAIR protocol [1566] FX This work is supported by the Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center under WRAIR protocol 1566. NR 37 TC 19 Z9 21 U1 0 U2 7 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JUN PY 2010 VL 48 IS 6 BP 2217 EP 2222 DI 10.1128/JCM.00029-10 PG 6 WC Microbiology SC Microbiology GA 602DG UT WOS:000278118100034 PM 20410343 ER PT J AU Rau, TJ Merrill, LL McWhorter, SK Stander, VA Thomsen, CJ Dyslin, CW Crouch, JL Rabenhorst, MM Milner, JS AF Rau, Terri J. Merrill, Lex L. McWhorter, Stephanie K. Stander, Valerie A. Thomsen, Cynthia J. Dyslin, Christopher W. Crouch, Julie L. Rabenhorst, Mandy M. Milner, Joel S. TI Evaluation of a Sexual Assault Education/Prevention Program for Male US Navy Personnel SO MILITARY MEDICINE LA English DT Article ID EFFECT SIZE; AGGRESSION; RAPE; STATISTICS; DESIGNS; SAMPLE; WOMEN; MODEL AB A randomized clinical trial was conducted to evaluate the effectiveness of the Navy Sexual Assault Intervention Training (SAIT) program for men. A four-group Solomon design was used to control for possible pretest sensitization effects. Male Navy personnel (N = 1,505) were assessed for rape knowledge, rape myth acceptance (two scales), and rape empathy after participating in the SAIT program or viewing an educational video about HIV/AIDS (comparison condition). The SAIT program was found to be effective in increasing rape knowledge, reducing rape myth acceptance, and increasing empathy for rape victims. As expected, men who had exhibited previous coercive sexual behavior, compared with those who had not, reported lower levels of knowledge, higher levels of rape myth acceptance, and less rape empathy. However, the SAIT program was generally effective in changing men's knowledge, beliefs, and feelings on the key measures, regardless of participants' histories of coercive sexual behavior. C1 [Rau, Terri J.] Navy Installat Command, Navy Fleet & Family Support Program, Millington, TN 38055 USA. [Merrill, Lex L.; McWhorter, Stephanie K.; Stander, Valerie A.] Naval Hlth Res Ctr, Behav Sci & Epidemiol Dept, San Diego, CA 92106 USA. [Thomsen, Cynthia J.; Crouch, Julie L.; Rabenhorst, Mandy M.; Milner, Joel S.] No Illinois Univ, Dept Psychol, Ctr Study Family Violence & Sexual Assault, De Kalb, IL 60115 USA. [Dyslin, Christopher W.] Governors State Univ, Div Psychol & Counseling, University Pk, IL 60466 USA. RP Rau, TJ (reprint author), Navy Installat Command, Navy Fleet & Family Support Program, 5720 Integr Dr, Millington, TN 38055 USA. FU Department of Defense [6309] FX This represents the Naval Health Research Center (NHRC) report 08-45, supported by the Department of Defense, under work unit no. 6309. This research has been conducted in compliance with all applicable federal regulations governing the protection of human subjects in research (protocol NHRC 1996.0001). NR 26 TC 6 Z9 6 U1 2 U2 10 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 2010 VL 175 IS 6 BP 429 EP 434 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 607FS UT WOS:000278485100011 PM 20572476 ER PT J AU Malik, SW Stemper, BD Metkar, U Yoganandan, N Shender, BS Rao, RD AF Malik, Steven W. Stemper, Brian D. Metkar, Umesh Yoganandan, Narayan Shender, Barry S. Rao, Raj D. TI Location of the Transverse Foramen in the Subaxial Cervical Spine in a Young Asymptomatic Population SO SPINE LA English DT Article DE subaxial cervical spine; vertebral morphology; computerized tomography; vertebral artery; foramen transversarium; uncovertebral joint ID VERTEBRAL ARTERY INJURY; COMPUTED-TOMOGRAPHY; SURGICAL ANATOMY; ANTERIOR; DECOMPRESSION; SURGERY; REPAIR; VOLUNTEERS AB Study Design. Computerized tomography of the subaxial cervical spine in 98 young, asymptomatic North American volunteers. Objective. To provide normative data on subaxial transverse foramen dimensions and location in relation to surgical landmarks routinely used during operative intervention in the anterior cervical spine. Summary of Background Data. Vertebral artery injury during anterior cervical spinal surgery is a rare but potentially catastrophic injury. There have been no prior studies in a large group of young, asymptomatic subjects without pathology and where the age, weight, and gender are known. There are no published computerized tomography data evaluating distances between the tip of the uncovertebral joint and the medial margin of the uncovertebral joint, 2 commonly used surgical landmarks. Methods. Axial and reconstructed coronal computerized tomography images of cervical vertebrae from C3 to C7 in 98 asymptomatic young volunteers were analyzed to measure interforaminal distance, transverse foramen distance from anterior and posterior vertebral body margins, transverse foramen dimensions, and transverse foramen medial margin distance from the uncus tip and medial margin. Results. All measurements were significantly different between males and females, with smaller female dimensions. Interforaminal distance gradually increased from C3 to C7. Transverse foramen anterior margin in relation to the anterior vertebral body was significantly more posterior at C7 compared with the C3-C6 levels. Transverse foramen posterior margin in relation to the vertebral body posterior margin gradually moved anteriorly from C3 to C6 and then posterior again at C7. The vertebral uncus tip and medial margin in relation to the medial transverse foramen averaged 2.8 mm and 5.7 mm for males and 2.7 mm and 5.3 mm for females from C3 to C6. Conclusion. Useful morphometric data are provided that may assist the operating surgeon to avoid vertebral artery injury during anterior surgical approaches to the cervical spine. The medial margin of the uncovertebral joint may be the safest landmark to avoid vertebral artery injury during anterior cervical disc surgery. The vertebral artery is at increased risk of injury during neural decompression at more cephalad levels. C1 [Malik, Steven W.; Metkar, Umesh; Yoganandan, Narayan; Rao, Raj D.] Med Coll Wisconsin, Dept Orthopaed Surg, Milwaukee, WI 53226 USA. [Stemper, Brian D.; Yoganandan, Narayan] Med Coll Wisconsin, Dept Neurosurg, Milwaukee, WI 53226 USA. [Shender, Barry S.] USN, Air Warfare Ctr, Aerosp Med Assoc, Patuxent River, MD USA. RP Rao, RD (reprint author), Med Coll Wisconsin, Dept Orthopaed Surg, 9200 W Wisconsin Ave, Milwaukee, WI 53226 USA. EM rrao@mcw.edu FU Federal funds FX Federal funds were received in support of this work. No benefits in any form have been or will be received from a commercial party related directly or indirectly to the subject of this manuscript. NR 24 TC 3 Z9 5 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD MAY 20 PY 2010 VL 35 IS 12 BP E514 EP E519 DI 10.1097/BRS.0b013e3181ce5332 PG 6 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 601PJ UT WOS:000278074400005 PM 20445473 ER PT J AU Wells, TS Bukowinski, AT Smith, TC Smith, B Dennis, LK Chu, LK Gray, GC Ryan, MAK AF Wells, Timothy S. Bukowinski, Anna T. Smith, Tyler C. Smith, Besa Dennis, Leslie K. Chu, Laura K. Gray, Gregory C. Ryan, Margaret A. K. TI Racial Differences in Prostate Cancer Risk Remain Among US Servicemen With Equal Access to Care SO PROSTATE LA English DT Article DE epidemiology; military personnel; occupational exposure; prostatic neoplasms ID HEALTH-CARE; TIME-SCALE; EPIDEMIOLOGY; SURVEILLANCE; CADMIUM; TRENDS; RACE AB BACKGROUND. Prostate cancer is the most common cancer among US men, however, the etiology remains unclear. Yet, one consistency is that black non-Hispanic men are at increased risk for prostate cancer compared to white, non-Hispanic men. The goal of this study was to assess relations between demographic and other potential prostate cancer risk factors in the context of the US military healthcare system, which provides equal access to all US servicemen. METHODS. Military healthcare and demographic data were used to describe risk factors for prostate cancer in the US military from September 1993 to September 2003. Cox's proportional hazards regression was employed to model the time to prostate cancer hospitalization. RESULTS. Four hundred eight first prostate cancer hospitalizations were identified among 2,761,559 servicemen. The adjusted rate per 100,000 persons rose from 1.41 to 3.62 for white non-Hispanic men and 1.43 to 6.08 for black non-Hispanic men by the end of the study. The increasing incidence over time for combined race/ethnic groups was similar to trends reported in the Surveillance, Epidemiology, and End Results Program for the US civilian population. No association was observed between occupation and prostate cancer hospitalization. However, black non-Hispanic men were at increased risk compared with white non-Hispanic men (hazard ratio = 2.72, 95% confidence interval: 2.12, 3.49). CONCLUSIONS. No association was observed between occupation and prostate cancer hospitalization. In this relatively young cohort, black non-Hispanic race/ethnicity was found to be predictive of prostate cancer, and this association existed regardless of access to care and socioeconomic status. Prostate 70: 727-734, 2010. (C) 2009 Wiley-Liss, Inc. C1 [Wells, Timothy S.] USAF, Res Lab, Dayton, OH USA. [Bukowinski, Anna T.; Smith, Tyler C.; Smith, Besa; Chu, Laura K.; Ryan, Margaret A. K.] USN, Hlth Res Ctr, US Dept Def, Ctr Deployment Hlth Res, San Diego, CA 92152 USA. [Dennis, Leslie K.; Gray, Gregory C.] Univ Iowa, Dept Epidemiol, Iowa City, IA USA. RP Wells, TS (reprint author), AFRL HEPA, 2800 Q St,Bldg 824,Room 206, Wright Patterson AFB, OH 45433 USA. EM timothy.wells@wpafb.af.mil FU Henry M. Jackson Foundation; Department of Defense [60002, W81XWH-04-1-0163] FX We thank Scott L. Seggerman from the Management Information Division, Defense Manpower Data Center, Seaside, CA. We appreciate the support of the Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, MD. This work represents report 08-31, which was additionally supported by the Department of Defense, under work unit no. 60002. This work was supported by the Department of Defense, Prostate Cancer Research Program of the Congressionally Directed Medical Research Programs[W81XWH-04-1-0163]. NR 20 TC 12 Z9 12 U1 0 U2 3 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0270-4137 J9 PROSTATE JI Prostate PD MAY 15 PY 2010 VL 70 IS 7 BP 727 EP 734 DI 10.1002/pros.21105 PG 8 WC Endocrinology & Metabolism; Urology & Nephrology SC Endocrinology & Metabolism; Urology & Nephrology GA 591XM UT WOS:000277338800005 PM 20033887 ER PT J AU Damon, AM Lessley, DJ Salzar, RS Bass, CR Shen, FH Paskoff, GR Shender, BS AF Damon, Andrew M. Lessley, David J. Salzar, Robert S. Bass, Cameron R. Shen, Francis H. Paskoff, Glenn R. Shender, Barry S. TI Kinematic Response of the Spine During Simulated Aircraft Ejections SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE postmortem human surrogate; spinal injury; military aviator; vertebrae ID CERVICAL MUSCLE RESPONSE; DYNAMIC-MOTION; INJURIES; HEAD; EXPERIENCE; WHIPLASH AB DAMON AM, LESSLEY DJ, SALZAR RS, BASS CR, SHEN FH, PASKOFF GR, SHENDER BS Kinematic response of the spine during simulated aircraft ejections. Aviat Space Environ Med 2010; 81:453-9. Introduction: Military aviators are susceptible to spinal injuries during high-speed ejection scenarios These injuries commonly arise as a result of strains induced by extreme flexion or compression of the spinal column This study characterizes the vertebral motion of two postmortem human surrogates (PMHS) during a simulated catapult phase of ejection on a horizontal decelerator sled Methods: During testing, the PMHS were restrained supinely to a mock ejection seat and subjected to a horizontal deceleration profile directed along the local z-axis Two midsized males (175 3 cm, 77 1 kg, 185 4 cm, 72 6 kg) were tested High-rate motion capture equipment was used to measure the three-dimensional displacement of the head, vertebrae, and pelvis during the ejection event Results: The two PMHS showed generally similar kinematic motion Head injury criterion (HIC) results were well below injury threshold levels for both specimens The specimens both showed compression of the spine, with a reduction in length of 23 0 mm and 45 7 mm Post-test autopsies revealed fractures in the C5, T1, and L1 vertebrae Discussion: This paper provides an analysis of spinal motion during an aircraft ejection The injuries observed in the test subjects were consistent with those seen in epidemiological studies Future studies should examine the effects of gender, muscle tensing, out-of-position (of head from neutral position) occupants, and external forces (e g, windblast) on spinal kinematics during aircraft ejection C1 [Damon, Andrew M.; Lessley, David J.; Salzar, Robert S.] Univ Virginia, Ctr Appl Biomech, Charlottesville, VA 22902 USA. [Shen, Francis H.] Univ Virginia, Dept Orthoped Surg, Charlottesville, VA 22902 USA. [Bass, Cameron R.] Duke Univ, Dept Biomed Engn, Durham, NC 27706 USA. [Paskoff, Glenn R.; Shender, Barry S.] USN, Human Syst Dept, Air Warfare Ctr, Div Aircraft, Patuxent River, MD USA. RP Damon, AM (reprint author), Univ Virginia, Ctr Appl Biomech, 1011 Linden Ave, Charlottesville, VA 22902 USA. NR 27 TC 2 Z9 2 U1 0 U2 3 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD MAY PY 2010 VL 81 IS 5 BP 453 EP 459 DI 10.3357/ASEM.2688.2010 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 589FY UT WOS:000277133500001 PM 20464811 ER PT J AU Conlin, AS Gumbs, GR Sevick, CJ Snell, KJ Descisciolo, C Smith, TC AF Conlin, A. S. Gumbs, G. R. Sevick, C. J. Snell, K. J. Descisciolo, C. Smith, T. C. TI Organizing Pregnancy Registries during an Emergency Response SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Meeting Abstract C1 [Conlin, A. S.; Gumbs, G. R.; Sevick, C. J.; Snell, K. J.; Descisciolo, C.; Smith, T. C.] Naval Hlth Res Ctr, San Diego, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD MAY PY 2010 VL 88 IS 5 BP 405 EP 405 PG 1 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA 605AV UT WOS:000278320600148 ER PT J AU Milner, JS Thomsen, CJ Crouch, JL Rabenhorst, MM Martens, PM Dyslin, CW Guimond, JM Stander, VA Merrill, LL AF Milner, Joel S. Thomsen, Cynthia J. Crouch, Julie L. Rabenhorst, Mandy M. Martens, Patricia M. Dyslin, Christopher W. Guimond, Jennifer M. Stander, Valerie A. Merrill, Lex L. TI Do trauma symptoms mediate the relationship between childhood physical abuse and adult child abuse risk? SO CHILD ABUSE & NEGLECT LA English DT Article DE Childhood physical abuse; Trauma symptoms; Trauma mediation; Adult child abuse risk ID POSTTRAUMATIC-STRESS-DISORDER; POTENTIAL INVENTORY; ADOLESCENT MOTHERS; DATING VIOLENCE; SOCIAL SUPPORT; SEXUAL-ABUSE; INTERPERSONAL SCHEMATA; ANTISOCIAL-BEHAVIOR; MALTREATMENT; ASSOCIATION AB Objective: Although the intergenerational transmission of family violence has been well documented, the mechanisms responsible for this effect have not been fully determined. The present study examined whether trauma symptoms mediate the relationship between a childhood history of child physical abuse (CPA) and adult CPA risk, and whether any such mediation was similar for women and men. Method: Female and male US Navy (USN) recruits (N = 5,394) and college students (N = 716) completed self-report measures of their history of child abuse (i.e., CPA and child sexual abuse [CSA]), exposure to intimate partner violence (IPV), current trauma symptoms, and adult CPA risk. Results: As expected, there was a strong association between a childhood history of CPA and adult CPA risk. This association was significant even after controlling for demographic variables and childhood exposure to other forms of violence (CSA and IPV), and the strength of the relationship did not vary depending on demographics or exposure to other forms of violence. However, the association between a history of CPA and adult risk of CPA was stronger for individuals high in defensive avoidance compared to those low in defensive avoidance. The association between a history of CPA and adult CPA risk was largely, although not entirely, mediated by psychological trauma symptoms. Mediation was observed for both women and men in both the USN and college samples. Conclusions: Trauma symptoms associated with a history of CPA accounted for a substantial part of the relationship between a history of CPA and adult CPA risk in both women and men. Practice implications: To the extent that trauma symptoms are a mechanism by which the intergenerational transmission of child abuse occurs, intervening to reduce trauma symptoms in CPA victims has the potential of reducing their risk of continuing the cycle of violence. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Milner, Joel S.; Thomsen, Cynthia J.; Crouch, Julie L.; Rabenhorst, Mandy M.] No Illinois Univ, Ctr Study Family Violence & Sexual Assault, De Kalb, IL 60115 USA. [Martens, Patricia M.] Kennedy Krieger Inst, Family Ctr, Baltimore, MD USA. [Dyslin, Christopher W.] Governors State Univ, Dept Psychol & Counseling, University Pk, PA USA. [Guimond, Jennifer M.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Stander, Valerie A.; Merrill, Lex L.] USN, Med Informat Syst & Operat Res Dept, Hlth Res Ctr, San Diego, CA 92152 USA. RP Milner, JS (reprint author), No Illinois Univ, Ctr Study Family Violence & Sexual Assault, De Kalb, IL 60115 USA. OI Guimond, Jennifer/0000-0002-8887-5885 NR 89 TC 25 Z9 29 U1 5 U2 26 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0145-2134 J9 CHILD ABUSE NEGLECT JI Child Abuse Negl. PD MAY PY 2010 VL 34 IS 5 BP 332 EP 344 DI 10.1016/j.chiabu.2009.09.017 PG 13 WC Family Studies; Psychology, Social; Social Work SC Family Studies; Psychology; Social Work GA 597SF UT WOS:000277780800006 PM 20359748 ER PT J AU Gross, ML Beckstead, MW AF Gross, Matthew L. Beckstead, Merrill W. TI Diffusion flame calculations for composite propellants predicting particle-size effects SO COMBUSTION AND FLAME LA English DT Article DE Ammonium perchlorate; Solid propellants; Combustion modeling; Energetic materials; Flame structure ID VORTICITY-VELOCITY FORMULATION; AMMONIUM-PERCHLORATE; KINETICS; COMBUSTION; FLOWS; MODEL AB The complexities of the flame structure above a composite propellant containing 86% ammonium perchlorate (AP) and 14% hydroxy-terminated-polybutadiene (HTPB) have been elucidated using a two-dimensional, detailed gas-phase kinetic mechanism diffusion flame model. The model utilizes a vorticity formulation of the transport equations, which essentially eliminates the pressure field calculation and speeds convergence. Mass and energy coupling between the condensed and gas phases are achieved through iteration with one-dimensional, premixed combustion models to dynamically update the inlet boundary conditions. The model uses a detailed gas-phase kinetic mechanism consisting of 37 species and 127 reactions. Numerical studies have been performed to examine the influence of particle size on the flame structure above the AP/HTPB propellant. Three different combustion zones, based on AP particle size, were predicted: the AP monopropellant limit, the diffusion flame region, and the premixed limit. The modeled flame structure changed dramatically with particle size and was found to be qualitatively similar to the Beckstead-Derr-Price Model. Mechanistic insights are presented to explain AP's unique ability to modify a propellant burning rate based on particle size alone. The premixed limit at which decreasing the size of the AP particles no longer influences the burning rate was also predicted. Results show promise in predicting formulistic effects using fundamental calculations. Published by Elsevier Inc. on behalf of The Combustion Institute. C1 [Gross, Matthew L.] USN, Air Warfare Ctr, Weap Div, China Lake, CA 93555 USA. [Beckstead, Merrill W.] Brigham Young Univ, Dept Chem Engn, Provo, UT 84602 USA. RP Gross, ML (reprint author), USN, Air Warfare Ctr, Weap Div, China Lake, CA 93555 USA. EM matthew.gross1@navy.mil FU NAVAIR ILIR program; N-STAR program (Naval Research - Science and Technology for America's Readiness) FX This work was sponsored by the NAVAIR ILIR program, managed at ONR by the N-STAR program (Naval Research - Science and Technology for America's Readiness). NR 27 TC 9 Z9 9 U1 1 U2 9 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0010-2180 J9 COMBUST FLAME JI Combust. Flame PD MAY PY 2010 VL 157 IS 5 BP 864 EP 873 DI 10.1016/j.combustflame.2009.09.004 PG 10 WC Thermodynamics; Energy & Fuels; Engineering, Multidisciplinary; Engineering, Chemical; Engineering, Mechanical SC Thermodynamics; Energy & Fuels; Engineering GA 570OM UT WOS:000275687600003 ER PT J AU Sueker, JJ Blazes, DL Johns, MC Blair, PJ Sjoberg, PA Tjaden, JA Montgomery, JM Pavlin, JA Schnabel, DC Eick, AA Tobias, S Quintana, M Vest, KG Burke, RL Lindler, LE Mansfield, JL Erickson, RL Russell, KL Sanchez, JL AF Sueker, J. Jeremy Blazes, David L. Johns, Matthew C. Blair, Patrick J. Sjoberg, Paul A. Tjaden, Jeffrey A. Montgomery, Joel M. Pavlin, Julie A. Schnabel, David C. Eick, Angelia A. Tobias, Steven Quintana, Miguel Vest, Kelly G. Burke, Ronald L. Lindler, Luther E. Mansfield, Jay L. Erickson, Ralph Loren Russell, Kevin L. Sanchez, Jose L. CA DoD Influenza Working Grp TI Influenza and respiratory disease surveillance: the US military's global laboratory-based network SO INFLUENZA AND OTHER RESPIRATORY VIRUSES LA English DT Review DE Influenza; military; surveillance ID BASIC TRAINEES; VACCINES; ADENOVIRUS; PERSONNEL; SYSTEM AB The US Department of Defense influenza surveillance system now spans nearly 500 sites in 75 countries, including active duty US military and dependent populations as well as host-country civilian and military personnel. This system represents a major part of the US Government's contributions to the World Health Organization's Global Influenza Surveillance Network and addresses Presidential Directive NSTC-7 to expand global surveillance, training, research and response to emerging infectious disease threats. Since 2006, the system has expanded significantly in response to rising pandemic influenza concerns. The expanded system has played a critical role in the detection and monitoring of ongoing H5N1 outbreaks worldwide as well as in the initial detection of, and response to, the current (H1N1) 2009 influenza pandemic. This article describes the system, details its contributions and the critical gaps that it is filling, and discusses future plans. C1 [Sanchez, Jose L.] USAPHC Prov, Div GEIS Operat, AFHSC, Silver Spring, MD 20910 USA. [Blair, Patrick J.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Tjaden, Jeffrey A.] US Naval Med Res Unit 3, Cairo, Egypt. [Montgomery, Joel M.] US Naval Med Res Ctr Detachment, Lima, Peru. [Pavlin, Julie A.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Schnabel, David C.] US Army Med Res Unit, Nairobi, Kenya. [Tobias, Steven] US Naval Med Res Unit 2, Jakarta, Indonesia. [Sjoberg, Paul A.] USAF, Sch Aerosp Med, Brooks City Base, TX USA. RP Sanchez, JL (reprint author), USAPHC Prov, Div GEIS Operat, AFHSC, 2900 Linden Lane,Suite 100, Silver Spring, MD 20910 USA. EM toti.sanchez@us.army.mil RI Valle, Ruben/A-7512-2013; Bulimo, Wallace/B-1982-2014 OI Bulimo, Wallace/0000-0001-8475-0586 FU DoD Global Emerging Surveillance and Response System (DoD-GEIS); Armed Forces Health Surveillance Center (AFHSC) FX This study was supported by the US Military's Defense Health Program funding of the DoD Global Emerging Surveillance and Response System (DoD-GEIS) and the Armed Forces Health Surveillance Center (AFHSC). NR 31 TC 13 Z9 13 U1 0 U2 6 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1750-2640 J9 INFLUENZA OTHER RESP JI Influenza Other Respir. Viruses PD MAY PY 2010 VL 4 IS 3 BP 155 EP 161 DI 10.1111/j.1750-2659.2010.00129.x PG 7 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA 579GF UT WOS:000276356100007 ER PT J AU Chan, KS Enright, MP Moody, JP Golden, PJ Chandra, R Pentz, AC AF Chan, Kwai S. Enright, Michael P. Moody, Jonathan P. Golden, Patrick J. Chandra, Ramesh Pentz, Alan C. TI Residual stress profiles for mitigating fretting fatigue in gas turbine engine disks SO INTERNATIONAL JOURNAL OF FATIGUE LA English DT Article; Proceedings Paper CT 138th TMS Annual Symposium on Mechanisms, Theory, Experiments and Industrial Practice in Fatigue CY 2009 CL San Francisco, CA SP TMS DE Fretting; Fatigue; Residual stress; Probabilistic methods; Low plasticity burnishing; Engine disks ID FOREIGN OBJECT DAMAGE; MECHANICS AB The driving force for fretting fatigue in engine disks is the contact stresses generated by fretting of the blade and the disk surfaces in the attachment region. This paper examines the use of different residual compressive stress profiles to counteract the undesirable effects of contact stresses and to mitigate fretting fatigue. A global finite-element analysis of the disk blade assembly is first performed. The contact pressure and shear traction at the attachment region are extracted from the FEM results and used to compute the contact stress distribution. The contact stresses are then combined with the residual stresses and the bulk stresses. The overall stress distribution is then utilized in a probabilistic crack growth model to predict the risk of disk failure for a military engine under simulated loading conditions. The results are used to identify the minimum residual stress profile for mitigating fretting fatigue in engine disks. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Chan, Kwai S.; Enright, Michael P.; Moody, Jonathan P.] SW Res Inst, San Antonio, TX 78238 USA. [Golden, Patrick J.] USAF, Res Lab, Wright Patterson AFB, OH 45433 USA. [Chandra, Ramesh; Pentz, Alan C.] NAVAIR, Patuxent River, MD 20670 USA. RP Chan, KS (reprint author), SW Res Inst, San Antonio, TX 78238 USA. EM kchan@swri.edu NR 28 TC 10 Z9 10 U1 3 U2 17 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0142-1123 J9 INT J FATIGUE JI Int. J. Fatigue PD MAY PY 2010 VL 32 IS 5 BP 815 EP 823 DI 10.1016/j.ijfatigue.2009.07.004 PG 9 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 560TW UT WOS:000274927000005 ER PT J AU Metzgar, D AF Metzgar, David TI Mycoplasma pneumoniae Outbreaks on Navy Vessels - Reply SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Letter C1 USN, Hlth Res Ctr, Dept Resp Dis Res Code 66, San Diego, CA 92106 USA. RP Metzgar, D (reprint author), USN, Hlth Res Ctr, Dept Resp Dis Res Code 66, 140 Sylvester Rd, San Diego, CA 92106 USA. EM david.metzgar@med.navy.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAY PY 2010 VL 48 IS 5 BP 1990 EP 1990 PG 1 WC Microbiology SC Microbiology GA 592DV UT WOS:000277356600091 ER PT J AU Champion, HR Holcomb, JB Lawnick, MM Kelliher, T Spott, MA Galarneau, MR Jenkins, DH West, SA Dye, J Wade, CE Eastridge, BJ Blackbourne, LH Shair, EK AF Champion, Howard R. Holcomb, John B. Lawnick, Mary M. Kelliher, Timothy Spott, Mary Ann Galarneau, Michael R. Jenkins, Donald H. West, Susan A. Dye, Judy Wade, Charles E. Eastridge, Brian J. Blackbourne, Lorne H. Shair, Ellen Kalin TI Improved Characterization of Combat Injury SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Abbreviated Injury Scale (AIS); Maximum AIS (MAIS); AIS 2005-Military; Maximum AIS Military (MAIS-Military); Combat registry; Combat injury; Combat casualty; Injury; Database; Wounds ID OPERATION-ENDURING-FREEDOM; SYSTEM; THEATER; CARE AB Background: Combat injury patterns differ from civilian trauma in that the former are largely explosion-related, comprising multiple mechanistic and fragment injuries and high-kinetic-energy bullets. Further, unlike civilians, U. S. armed forces combatants are usually heavily protected with helmets and Kevlar body armor with ceramic plate inserts. Searchable databases providing actionable, statistically valid knowledge of body surface entry wounds and resulting organ injury severity are essential to understanding combat trauma. Methods: Two tools were developed to address these unique aspects of combat injury: ( 1) the Surface Wound Mapping (SWM) database and Surface Wound Analysis Tool (SWAT) software that were developed to generate 3D density maps of point-of-surface wound entry and resultant anatomic injury severity; and (2) the Abbreviated Injury Scale (AIS) 2005-Military that was developed by a panel of military trauma surgeons to account for multiple injury etiology from explosions and other high-kinetic-energy weapons. Combined data from the Joint Theater Trauma Registry, Navy/Marine Combat Trauma Registry, and the Armed Forces Medical Examiner System Mortality Trauma Registry were coded in AIS 2005-Military, entered into the SWM database, and analyzed for entrance site and wounding path. Results: When data on 1,151 patients, who had a total of 3,500 surface wounds and 12,889 injuries, were entered into SWM, surface wounds averaged 3.0 per casualty and injuries averaged 11.2 per casualty. Of the 3,500 surface wounds, 2,496 (71%) were entrance wounds with 6,631 (51%) associated internal injuries, with 2.2 entrance wounds and 5.8 associated injuries per casualty (some details cannot be given because of operational security). Crude deaths rates were calculated using Maximum AIS-Military. Conclusion: These new tools have been successfully implemented to describe combat injury, mortality, and distribution of wounds and associated injuries. AIS 2005-Military is a more precise assignment of severity to military injuries. SWM has brought data from all three combat registries together into one analyzable database. SWM and SWAT allow visualization of wounds and associated injuries by region on a 3D model of the body. C1 [Champion, Howard R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Holcomb, John B.] Univ Texas Hlth Sci Ctr, Houston, TX USA. [Lawnick, Mary M.; Kelliher, Timothy; Shair, Ellen Kalin] SimQuest LLC, Silver Spring, MD USA. [Spott, Mary Ann; West, Susan A.; Eastridge, Brian J.; Blackbourne, Lorne H.] USA, Inst Surg Res, Houston, TX USA. [Galarneau, Michael R.; Dye, Judy] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Jenkins, Donald H.] Mayo Clin, Rochester, MN USA. [Wade, Charles E.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP Champion, HR (reprint author), 954 Melvin Rd, Annapolis, MD 21403 USA. EM hrchampion@aol.com FU US Army [W81XWH-04-0020, DAMD-01-P-0485, W81XWH-04-C-0134, W81XWH-06-C-0365, N41756-06-C-5518, W81XWH-05-2-0057] FX Supported by the US Army under Contract Nos. W81XWH-04-0020, DAMD-01-P-0485, W81XWH-04-C-0134, W81XWH-06-C-0365, N41756-06-C-5518, and W81XWH-05-2-0057. NR 23 TC 56 Z9 57 U1 0 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD MAY PY 2010 VL 68 IS 5 BP 1139 EP 1150 DI 10.1097/TA.0b013e3181d86a0d PG 12 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 595MQ UT WOS:000277615200020 PM 20453770 ER PT J AU Knapik, JJ Trone, D Brosch, L Hauret, K Grier, T Bullock, SB Jones, B AF Knapik, Joseph J. Trone, Daniel Brosch, Lorie Hauret, Keith Grier, Tyson Bullock, Steve B. Jones, Bruce TI Does Assigning Running Shoes Based on Plantar Shape Reduce Injury Risk? A Meta-Analysis SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Knapik, Joseph J.; Hauret, Keith; Grier, Tyson; Bullock, Steve B.; Jones, Bruce] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD USA. [Brosch, Lorie] 37th Med Grp, Lackland AFB, TX USA. [Trone, Daniel] USN, Hlth Res Ctr, San Diego, CA 92152 USA. EM joseph.knapik@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 1048 BP 145 EP 145 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226300410 ER PT J AU Taylor, MK Ward, MDD Padilla, GA Evans, KE Markham, AE Khosravi, JY Koehler, MM Phillips, JB AF Taylor, Marcus K. Ward, Michael D. Dial Padilla, Genieleah A. Evans, Katherine E. Markham, Amanda E. Khosravi, Jasmine Y. Koehler, Matthew M. Phillips, Jeffrey B. TI Hormonal Reactivity to Extreme Military Stress: Effect Of Psychological Skills Training SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Taylor, Marcus K.; Khosravi, Jasmine Y.; Phillips, Jeffrey B.] USN, Aerosp Med Res Lab, Pensacola, FL USA. [Ward, Michael D. Dial; Koehler, Matthew M.] Ctr Secur Forces Learning Site SERE W, San Diego, CA USA. [Padilla, Genieleah A.; Evans, Katherine E.; Markham, Amanda E.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. EM marc.taylor@med.navy.mil NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 1476 BP 287 EP 288 PG 2 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226301132 ER PT J AU Hascall, JL Thom, NJ Johnson, DC Miller, PW AF Hascall, Jessie L. Thom, Nathaniel J. Johnson, Douglas C. Miller, Paul W. TI Aerobic Fitness, But Not Musculoskeletal Fitness, Is Inversely Associated With Changes In Perceived Stress SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Hascall, Jessie L.; Thom, Nathaniel J.; Johnson, Douglas C.; Miller, Paul W.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. EM jessie.hascall@med.navy.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 2278 BP 571 EP 571 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226302080 ER PT J AU Johnson, EC May, CA Wong, JM Jameson, JT Hodgdon, JA Heaney, JH AF Johnson, Evan C. May, Courtney A. Wong, Janine M. Jameson, Jason T. Hodgdon, James A. Heaney, Jay H. TI Core Temperature Response to Alternating Sedentary Water Immersion and Wet Clothing Air Exposure SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Johnson, Evan C.; May, Courtney A.; Wong, Janine M.; Jameson, Jason T.; Hodgdon, James A.; Heaney, Jay H.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. EM evan.johnson@med.navy.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 2478 BP 640 EP 640 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226302279 ER PT J AU Wang, Z Malanoski, AP Lin, BC Long, NC Leski, TA Blaney, KM Hansen, CJ Brown, J Broderick, M Stenger, DA Tibbetts, C Russell, KL Metzgar, D AF Wang, Zheng Malanoski, Anthony P. Lin, Baochuan Long, Nina C. Leski, Tomasz A. Blaney, Kate M. Hansen, Christian J. Brown, Jason Broderick, Michael Stenger, David A. Tibbetts, Clark Russell, Kevin L. Metzgar, David TI Broad Spectrum Respiratory Pathogen Analysis of Throat Swabs from Military Recruits Reveals Interference Between Rhinoviruses and Adenoviruses SO MICROBIAL ECOLOGY LA English DT Article ID RESEQUENCING DNA MICROARRAYS; POLYMERASE-CHAIN-REACTION; WITHIN-HOST EVOLUTION; TRACT INFECTIONS; MULTIPLEX PCR; ILLNESS; IDENTIFICATION; DISEASE; EPIDEMIOLOGY; SYMPTOMS AB Military recruits experience a high incidence of febrile respiratory illness (FRI), leading to significant morbidity and lost training time. Adenoviruses, group A Streptococcus pyogenes, and influenza virus are implicated in over half of the FRI cases reported at recruit training center clinics, while the etiology of the remaining cases is unclear. In this study, we explore the carriage rates and disease associations of adenovirus, enterovirus, rhinovirus, Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis in military recruits using high-density resequencing microarrays. The results showed that rhinoviruses, adenoviruses, S. pneumoniae, H. influenzae, and N. meningitidis were widely distributed in recruits. Of these five agents, only adenovirus showed significant correlation with illness. Among the samples tested, only pathogens associated with FRI, such as adenovirus 4 and enterovirus 68, revealed strong temporal and spatial clustering of specific strains, indicating that they are transmitted primarily within sites. The results showed a strong negative association between adenoviral FRI and the presence of rhinoviruses in recruits, suggesting some form of viral interference. C1 [Wang, Zheng; Malanoski, Anthony P.; Lin, Baochuan; Leski, Tomasz A.; Stenger, David A.] USN, Res Lab, Ctr Biomol Sci & Engn, Washington, DC 20375 USA. [Long, Nina C.; Blaney, Kate M.] Nova Res Inc, Alexandria, VA USA. [Hansen, Christian J.; Brown, Jason; Broderick, Michael; Russell, Kevin L.; Metzgar, David] USN, Hlth Res Ctr, Dept Resp Dis Res, San Diego, CA 92152 USA. [Tibbetts, Clark] Tessarae LLC, Potomac Falls, VA USA. [Russell, Kevin L.] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD USA. RP Wang, Z (reprint author), USN, Res Lab, Ctr Biomol Sci & Engn, Washington, DC 20375 USA. EM zheng.wang@nrl.navy.mil; david.metzgar@med.navy.mil RI Malanoski, Anthony/C-7814-2011; Valle, Ruben/A-7512-2013; Leski, Tomasz/K-6916-2013; Lin, Baochuan/A-8390-2009 OI Malanoski, Anthony/0000-0001-6192-888X; Leski, Tomasz/0000-0001-7688-9887; Lin, Baochuan/0000-0002-9484-0785 FU Office of Naval Research via Naval Research Laboratory; Global Emerging Infections Surveillance and Response System (GEIS), a Division of the Armed Forces Health Surveillance Center, Silver Spring, MD under NHRC [60805] FX This work represents NHRC report number 09-20, supported in part by the Office of Naval Research via Naval Research Laboratory core funding and in part by the Global Emerging Infections Surveillance and Response System (GEIS), a Division of the Armed Forces Health Surveillance Center, Silver Spring, MD www.afhsc.mil, under NHRC research work unit #60805. The views expressed in this work are those of the authors, and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, or the US Government. NR 42 TC 30 Z9 31 U1 0 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0095-3628 J9 MICROB ECOL JI Microb. Ecol. PD MAY PY 2010 VL 59 IS 4 BP 623 EP 634 DI 10.1007/s00248-010-9636-3 PG 12 WC Ecology; Marine & Freshwater Biology; Microbiology SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Microbiology GA 605LP UT WOS:000278349400001 PM 20217405 ER PT J AU Rauh, MJ Macera, CA Trone, DW Reis, JP Shaffer, RA AF Rauh, Mitchell J. Macera, Caroline A. Trone, Daniel W. Reis, Jared P. Shaffer, Richard A. TI Selected Static Anatomic Measures Predict Overuse Injuries in Female Recruits SO MILITARY MEDICINE LA English DT Article ID ANTERIOR KNEE PAIN; PATELLOFEMORAL PAIN; RISK-FACTORS; STRESS-FRACTURES; ARMY RECRUITS; RUNNERS; TRAINEES; GENDER; WOMEN; ANGLE AB This prospective study determined whether selected anatomic measures identified women at increased risk of patellofemoral pain syndrome (PFPS) and shin splints (SS). Ten anatomic measures were performed on 748 women before basic training at the Marine Corps Recruit Depot (MCRD), Parris Island, South Carolina. Recruits were then followed throughout basic training for occurrence of injuries. Logistic regression modeling indicated that a left hip internal rotation range of motion (ROM) <= 25 degrees and >= 46 degrees, a right Q angle >= 20 degrees, and left knee hyperextension ROM >= 6 degrees were positively associated with PFPS. Whereas left dorsiflexion ROM >= 21 degrees was associated with SS, right Q angle >= 20 degrees was inversely associated with SS. These findings suggest that multiple anatomic measures can be used to identify women entering MCRD basic training at risk for PFPS and SS injuries. C1 [Rauh, Mitchell J.; Macera, Caroline A.; Trone, Daniel W.; Shaffer, Richard A.] USN, Hlth Res Ctr, San Diego, CA 92106 USA. [Rauh, Mitchell J.; Macera, Caroline A.; Shaffer, Richard A.] San Diego State Univ, Grad Sch Publ Hlth, San Diego, CA 92182 USA. [Rauh, Mitchell J.; Macera, Caroline A.] Sci Applicat Int Corp, San Diego, CA 92121 USA. [Rauh, Mitchell J.] Rocky Mt Univ Hlth Profess, Grad Program Orthoped & Sports Phys Therapy, Provo, UT 84606 USA. [Trone, Daniel W.] Univ Calif San Diego, Joint Doctoral Program Publ Hlth Epidemiol, San Diego, CA 92182 USA. [Reis, Jared P.] NHLBI, Populat Sci Program, Div Cardiovasc Sci, Rockedge Ctr 2, Bethesda, MD 20892 USA. RP Rauh, MJ (reprint author), USN, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. FU Department of Defense [60213]; [NHRC.2002.0020] FX This research has been conducted in compliance with all applicable federal regulations governing the protection of human subjects in research protocol NHRC.2002.0020. This work was supported by the Department of Defense, under work unit no. 60213. NR 36 TC 6 Z9 6 U1 2 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 2010 VL 175 IS 5 BP 329 EP 335 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 598FH UT WOS:000277819700008 PM 20486504 ER PT J AU Harris, E Olshenske, Z AF Harris, E. Olshenske, Z. TI Aligned Discontinuous Fiber-based Formable Textiles for Aircraft Composite Repair SO SAMPE JOURNAL LA English DT Article AB Lightweight, polymer matrix composites (PMC's) are an enabling material for Naval aircraft providing a combination of high stiffness to weight ratio and improved corrosion and fatigue resistance. In service Navy aircraft which incorporate extensive composite structure, though, are often subject to impact related damage resulting in various defects in the components which need to be repaired. Bonded patch repair processes are a preferred field repair solution (versus bolted repairs) as the resulting repair joint can obtain the stiffness and strength of the original part skin if performed correctly. Obtaining quality bonded repair joints becomes increasingly difficult, though, as the complex curvature of the part increases, even when using wet layup, fabric based laminate patches. This preliminary study evaluates the benefits of utilizing a new aligned, discontinuous "formable" textile called DiscoTex (R) (in development by Pepin Associates) for producing laminate patches for bonded repairs on select double curvature composite shapes typical of those geometries found on fixed wing fighter aircraft. C1 [Harris, E.] NAVAIR, Mat Engn Div, San Diego, CA USA. NAVAIR, Mat Engn Div, Patuxent River, MD USA. RP Harris, E (reprint author), NAVAIR, Mat Engn Div, San Diego, CA USA. EM Edward.W.Harris@navy.mil NR 4 TC 1 Z9 1 U1 0 U2 2 PU SAMPE PUBLISHERS PI COVINA PA 1161 PARKVIEW DRIVE, COVINA, CA 91722 USA SN 0091-1062 J9 SAMPE J JI Sampe J. PD MAY-JUN PY 2010 VL 46 IS 3 BP 16 EP 25 PG 10 WC Engineering, Multidisciplinary; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 583ZC UT WOS:000276718200002 ER PT J AU Arnold, J Janoska, M Kajon, AE Metzgar, D Hudson, NR Torres, S Harrach, B Seto, D Chodosh, J Jones, MS AF Arnold, John Janoska, Mate Kajon, Adriana E. Metzgar, David Hudson, Nolan Ryan Torres, Sarah Harrach, Balazs Seto, Donald Chodosh, James Jones, Morris S. TI Genomic characterization of human adenovirus 36, a putative obesity agent SO VIRUS RESEARCH LA English DT Article DE Human adenovirus; Bioinformatics; Genomics ID EPIDEMIC KERATOCONJUNCTIVITIS; PROTEIN; INTERNALIZATION; ADIPOSITY; GENE; DIFFERENTIATION; OVERWEIGHT; CHICKEN; BINDING; WEIGHT AB Increased levels of serum antibody titers against human adenovirus 36 (HAdV-D36) are associated with human obesity and experimental obesity in laboratory animals. While HAdV-D36 has been studied as an infectious agent implicated in obesity for over a decade, the complete genome sequence and its analysis have yet to be reported. A detailed analysis of the genome sequence of HAdV-D36 may be important to understand its role in obesity. Genomic and bioinformatic comparisons with other HAdVs identified differences that suggested unique functions. Global pairwise genome alignment with all sequenced human adenovirus D (HAdV-D) genomes revealed areas of nonconserved sequences in the hexon, E3 CR1 beta, E3 CR1 gamma, and fiber genes. Phylogenetic analysis of all HAdV-D36 proteins confirmed that this virus belongs to species Human adenovirus D. This genomic analysis of HAdV-D36 provides an important tool for comprehending the role that this unique adenovirus may play in human obesity. Low amino acid sequence identity in the E3 CR1 beta and CR1 gamma genes may suggest distinctive roles for these proteins. Furthermore, the predicted molecular models of the HAdV-D36 fiber protein seem to implicate a unique tissue tropism for HAdV-D36. Published by Elsevier B.V. C1 [Jones, Morris S.] David Grant USAF Med Ctr, Clin Invest Facil, Travis, CA USA. [Arnold, John] USN, San Diego Med Ctr, Dept Pediat, Div Infect Dis, San Diego, CA 92152 USA. [Janoska, Mate; Harrach, Balazs] Hungarian Acad Sci, Vet Med Res Inst, H-1581 Budapest, Hungary. [Kajon, Adriana E.] Lovelace Resp Res Inst, Albuquerque, NM USA. [Metzgar, David] USN, Hlth Res Ctr, Dept Resp Dis Res, San Diego, CA 92152 USA. [Hudson, Nolan Ryan; Torres, Sarah; Seto, Donald] George Mason Univ, Dept Bioinformat & Computat Biol, Manassas, VA USA. [Chodosh, James] Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Howe Lab, Boston, MA USA. RP Jones, MS (reprint author), David Grant USAF Med Ctr, Clin Invest Facil, Travis, CA USA. EM drmorrisj@yahoo.com RI Harrach, Balazs/A-3680-2008; Valle, Ruben/A-7512-2013 OI Harrach, Balazs/0000-0002-1410-6469; FU Hungarian Research Fund [K72484]; U.S. Public Health Service NIH [EY013124, P30EY013104]; Massachusetts Lions Eye Research Fund, Inc.; Research to Prevent Blindness, Inc FX BH was supported by Hungarian Research Fund grant K72484. JC was supported in part by U.S. Public Health Service NIH grants EY013124 and P30EY013104, Massachusetts Lions Eye Research Fund, Inc., and an unrestricted grant to the Department of Ophthalmology, Harvard Medical School from Research to Prevent Blindness, Inc. NR 43 TC 20 Z9 22 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-1702 J9 VIRUS RES JI Virus Res. PD MAY PY 2010 VL 149 IS 2 BP 152 EP 161 DI 10.1016/j.virusres.2010.01.011 PG 10 WC Virology SC Virology GA 587BU UT WOS:000276962700003 PM 20109503 ER PT J AU Zerilli, FJ Kuklja, MM AF Zerilli, Frank J. Kuklja, Maija M. TI Ab Initio Equation of State of the Organic Molecular Crystal: beta-Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine SO JOURNAL OF PHYSICAL CHEMISTRY A LA English DT Article ID BETA-HMX; 1,1-DIAMINO-2,2-DINITROETHYLENE AB We apply a simple strategy for calculating from first principles a thermodynamically complete equation of state for molecular crystals using readily available quantum chemistry techniques. The strategy involves a combination of separate methods for the temperature-independent mechanical compression and the thermal vibrational contributions to the free energy. A first principles equation of state for beta-octahydro-1,3,5,7-tetranitro1,3,5,7-tetrazocine (beta-HMX) has been calculated for temperatures between 0 and 400 K and for specific volumes from 0.42 to 0.55 cm(3)/g, corresponding to relative volumes from 0.8 to 1.03. The calculated 300 K isotherm agrees very well with the experimentally measured pressure volume relation. We also discuss thermodynamic properties of the material such as the volumetric thermal expansion coefficient, the Grtineisen parameter, and the specific heat (1.0 kJ/kg/K at 300 K and atmospheric pressure). The developed computational approach exhibits a reliable predictive power and is easily transferable to other molecular materials. C1 [Kuklja, Maija M.] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA. [Zerilli, Frank J.] Naval Surface Warfare Ctr, Res & Technol Dept, Indian Head, MD 20640 USA. RP Kuklja, MM (reprint author), Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA. EM mkukla@nsf.gov NR 28 TC 15 Z9 15 U1 1 U2 8 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1089-5639 J9 J PHYS CHEM A JI J. Phys. Chem. A PD APR 29 PY 2010 VL 114 IS 16 BP 5372 EP 5376 DI 10.1021/jp911767q PG 5 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 586FM UT WOS:000276888800018 PM 20364852 ER PT J AU Paulus, MP Simmons, AN Fitzpatrick, SN Potterat, EG Van Orden, KF Bauman, J Swain, JL AF Paulus, Martin P. Simmons, Alan N. Fitzpatrick, Summer N. Potterat, Eric G. Van Orden, Karl F. Bauman, James Swain, Judith L. TI Differential Brain Activation to Angry Faces by Elite Warfighters: Neural Processing Evidence for Enhanced Threat Detection SO PLOS ONE LA English DT Article ID AVERSIVE VISUAL-STIMULI; INSULAR CORTEX; ORBITOFRONTAL CORTEX; ANTERIOR CINGULATE; PREDICTION ERRORS; FUNCTIONAL NEUROANATOMY; DECISION-MAKING; EMOTION; PERFORMANCE; AMYGDALA AB Background: Little is known about the neural basis of elite performers and their optimal performance in extreme environments. The purpose of this study was to examine brain processing differences between elite warfighters and comparison subjects in brain structures that are important for emotion processing and interoception. Methodology/Principal Findings: Navy Sea, Air, and Land Forces (SEALs) while off duty (n = 11) were compared with n = 23 healthy male volunteers while performing a simple emotion face-processing task during functional magnetic resonance imaging. Irrespective of the target emotion, elite warfighters relative to comparison subjects showed relatively greater right-sided insula, but attenuated left-sided insula, activation. Navy SEALs showed selectively greater activation to angry target faces relative to fearful or happy target faces bilaterally in the insula. This was not accounted for by contrasting positive versus negative emotions. Finally, these individuals also showed slower response latencies to fearful and happy target faces than did comparison subjects. Conclusions/Significance: These findings support the hypothesis that elite warfighters deploy greater processing resources toward potential threat-related facial expressions and reduced processing resources to non-threat-related facial expressions. Moreover, rather than expending more effort in general, elite warfighters show more focused neural and performance tuning. In other words, greater neural processing resources are directed toward threat stimuli and processing resources are conserved when facing a nonthreat stimulus situation. C1 [Paulus, Martin P.; Simmons, Alan N.; Fitzpatrick, Summer N.; Swain, Judith L.] Univ Calif San Diego, San Diego, CA 92103 USA. [Van Orden, Karl F.] Naval Hlth Res Ctr, San Diego, CA USA. [Bauman, James] US Olymp Training Ctr, Chula Vista, CA USA. [Potterat, Eric G.] Naval Special Warfare Ctr, San Diego, CA USA. [Paulus, Martin P.; Potterat, Eric G.; Van Orden, Karl F.; Bauman, James; Swain, Judith L.] OptiBrain Consortium, San Diego, CA USA. [Swain, Judith L.] ASTAR, Singapore Inst Clin Sci, Singapore, Singapore. [Swain, Judith L.] Natl Univ Singapore, Singapore 117548, Singapore. RP Paulus, MP (reprint author), Univ Calif San Diego, San Diego, CA 92103 USA. EM mpaulus@ucsd.edu RI Simmons, Alan/A-9815-2008 OI Simmons, Alan/0000-0003-3963-2112 FU VA Center of Excellence for Stress and Mental Health (CESAMH); Department of Veterans Affairs FX Some of this work was supported by the VA Center of Excellence for Stress and Mental Health (CESAMH), which is supported by Department of Veterans Affairs. CESAMH is affiliated with VISN 22, the Veterans Affairs San Diego Healthcare System, and the University of California, San Diego. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 73 TC 19 Z9 19 U1 4 U2 10 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 14 PY 2010 VL 5 IS 4 AR e10096 DI 10.1371/journal.pone.0010096 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 583VA UT WOS:000276706800007 PM 20418943 ER PT J AU Holbrook, TL Galarneau, MR AF Holbrook, Troy Lisa Galarneau, Michael R. TI Morphine after Combat Injury and Post-Traumatic Stress Disorder REPLY SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter C1 [Holbrook, Troy Lisa] EPI SOAR Consulting, San Diego, CA USA. [Galarneau, Michael R.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. RP Holbrook, TL (reprint author), EPI SOAR Consulting, San Diego, CA USA. EM troy@epi-soar.com NR 0 TC 0 Z9 0 U1 1 U2 1 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD APR 8 PY 2010 VL 362 IS 14 BP 1342 EP 1342 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA 579SN UT WOS:000276393700020 ER PT J AU Konek, CT Mason, BP Hooper, JP Stoltz, CA Wilkinson, J AF Konek, Christopher T. Mason, Brian P. Hooper, Joseph P. Stoltz, Chad A. Wilkinson, John TI Terahertz absorption spectra of 1,3,5,7-tetranitro-1,3,5,7-tetrazocane (HMX) polymorphs SO CHEMICAL PHYSICS LETTERS LA English DT Article ID THEORETICAL-ANALYSIS; CRYSTAL-STRUCTURE; THZ SPECTROSCOPY; INFRARED-SPECTRA; EXPLOSIVES; RAMAN; DELTA-OCTAHYDRO-1,3,5,7-TETRANITRO-1,3,5,7-TETRAZOCINE; DEPENDENCE; SOLIDS; BETA AB Interest in terahertz spectroscopy of organic compounds has been driven by its potential utility as a stand-off detection technology for explosives. Much work has focused on identifying the spectral signatures of explosives compounds and understanding the molecular origin of the complex, low-frequency modes in the terahertz regime. We present distinct absorption spectra in the terahertz region for polymorphs of the secondary high explosive 1,3,5,7-tetranitro-1,3,5,7-tetrazocane (HMX). For alpha-HMX, we couple experiments to solid-state density functional perturbation theory (DFPT) calculations, and find excellent agreement. This work underlines the importance of careful sample preparation when examining spectra and comparing experimental work with calculations. Published by Elsevier B.V. C1 [Konek, Christopher T.; Mason, Brian P.; Hooper, Joseph P.; Stoltz, Chad A.; Wilkinson, John] Naval Surface Warfare Ctr, Indian Head, MD 20640 USA. RP Wilkinson, J (reprint author), Naval Surface Warfare Ctr, 4104 Evans Way,Suite 102, Indian Head, MD 20640 USA. EM John.h.wilkinson@navy.mil FU Office of Naval Research; ASEE/NSWC FX This work was supported by an Independent Research grant from the Office of Naval Research. CTK and BPM acknowledge ASEE/NSWC postdoctoral fellowships. Additionally, the authors would like to thank Mike Kemp for helpful discussions, and Wayne Ouellette for the HMX graphics. NR 34 TC 30 Z9 32 U1 2 U2 25 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD APR 1 PY 2010 VL 489 IS 1-3 BP 48 EP 53 DI 10.1016/j.cplett.2010.02.042 PG 6 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 571LA UT WOS:000275752100010 ER PT J AU Bruno, ME Ortiz, P Moore, T Nesnow, S Winnik, W Yue, G AF Bruno, Maribel Enid Ortiz, Pedro Moore, Tanya Nesnow, Stephen Winnik, Witold Yue, Ge TI Proteomic Analysis of Propiconazole Responses in Mouse Liver-Comparison of Genomic and Proteomic Profiles SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Bruno, Maribel Enid; Moore, Tanya; Nesnow, Stephen] US EPA, Carcinogenesis Branch, Res Triangle Pk, NC 27711 USA. [Winnik, Witold; Yue, Ge] US EPA, Res Triangle Pk, NC 27711 USA. [Ortiz, Pedro] USN, Environm Hlth Effects Lab, Hlth Res Ctr, Wright Patterson AFB, OH USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2010 VL 24 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V28IW UT WOS:000208675501025 ER PT J AU Metzgar, D Gibbins, C Hudson, NR Jones, MS AF Metzgar, David Gibbins, Carl Hudson, N. Ryan Jones, Morris S. TI Evaluation of Multiplex Type-Specific Real-Time PCR Assays Using the LightCycler and Joint Biological Agent Identification and Diagnostic System Platforms for Detection and Quantitation of Adult Human Respiratory Adenoviruses SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID EPIDEMIC KERATOCONJUNCTIVITIS; MILITARY RECRUITS; PNEUMONIA; INFECTIONS; SEROTYPE; DISEASE AB Every year, thousands of basic military trainees in each service of the U. S. Armed Forces experience acute respiratory disease. The majority of this disease burden results from infection with human adeno-viruses. We designed single- and multiplex assays that detect and discriminate adenovirus types B3, E4, B7, B11, B14, and B21. A total of 116 oropharyngeal swab specimens obtained from patients at the Naval Health Research Center were used to validate the new assays. Type- specific singleplex assays were designed and used independently to successfully identify 94 representative patient specimens. The lower limits of detection for our singleplex real-time PCR assays were calculated to be 50, 500, 500, 50, 50, and 50 genomic copies per reaction for human adenovirus type B3 (HAdV-B3), HAdV-E4, HAdV-B7, HAdV-B11, HAdV-B14, and HAdV-B21, respectively. These were then multiplexed to increase efficiency and tested against singleplex assays using titrated controls. The HAdV-B3/B11 and HAdV-E4/B7 multiplex assays were as sensitive and specific as they were individually. The HAdV-B14/B21 multiplex assay was not as efficient at detecting HAdV-B14 as the singleplex assay. Interestingly, a statistically significant difference was found between the viral loads of HAdV-B14 and those of HAdV-B3, -E4, -B7, and -B21 (P < 0.001). The assays did not cross-react with other adenoviruses, influenza virus, respiratory syncytial virus, or respiratory disease-causing bacteria. These assays have the potential to be useful as clinical diagnostic tools for the detection of HAdV infection in adult populations. C1 [Gibbins, Carl; Hudson, N. Ryan; Jones, Morris S.] David Grant USAF Med Ctr, Clin Invest Facil, Travis AFB, CA 94535 USA. [Metzgar, David] USN, Hlth Res Ctr, Dept Resp Dis Res, San Diego, CA 92152 USA. RP Jones, MS (reprint author), David Grant USAF Med Ctr, Clin Invest Facil, Travis AFB, CA 94535 USA. EM drmorrisj@yahoo.com RI Valle, Ruben/A-7512-2013 FU U. S. Air Force Surgeon General-approved Clinical Investigation [FDG20080024E, FDG20080020E, FDG20080022E, FDG20080023E, FDG20080029E] FX We thank Ginny Gildengorn for statistical analysis and critical analysis of the manuscript.; The work reported herein was performed under U. S. Air Force Surgeon General-approved Clinical Investigation no. FDG20080024E, FDG20080020E, FDG20080022E, FDG20080023E, and FDG20080029E.; Informed consent was obtained in writing. The views expressed in this material are ours and do not reflect the official policy or position of the U. S. government, the Department of Defense, the Department of the Air Force, the Department of the Navy, or the Department of the Army. NR 25 TC 7 Z9 7 U1 0 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD APR PY 2010 VL 48 IS 4 BP 1397 EP 1403 DI 10.1128/JCM.01600-09 PG 7 WC Microbiology SC Microbiology GA 576OC UT WOS:000276153200053 PM 20053853 ER PT J AU Kajon, AE Dickson, LM Metzgar, D Houng, HS Lee, V Tan, BH AF Kajon, Adriana E. Dickson, Laura M. Metzgar, David Houng, Huo-Shu Lee, Vernon Tan, Boon-Huan TI Outbreak of Febrile Respiratory Illness Associated with Adenovirus 11a Infection in a Singapore Military Training Camp SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID GENOME TYPES; RECRUITS; DISEASE; PCR; HEALTHY; TYPE-11; ADULTS; GENE AB Outbreak cases of acute respiratory disease (ARD) associated with subspecies B2 human adenovirus 11a (HAdV-11a) infection were detected during 2005 in a military basic training camp in Singapore. The Singapore HAdV-11a strain is highly similar to other Asian strains of HAdV-11, including strain QS-DLL, which is responsible for the recently described 2006 outbreak of ARD in China. C1 [Kajon, Adriana E.; Dickson, Laura M.] LRRI, Program Infect Dis, Albuquerque, NM 87108 USA. [Metzgar, David] USN, Hlth Res Ctr, Dept Resp Dis Res, NHRC, San Diego, CA 92106 USA. [Houng, Huo-Shu] Walter Reed Army Inst Res, Dept Virus Dis, Silver Spring, MD 20910 USA. [Lee, Vernon] Biodef Ctr, Singapore 778910, Singapore. [Tan, Boon-Huan] Def Med & Environm Res Inst, Detect & Diagnost Lab, DSO Natl Labs, Singapore 117510, Singapore. RP Kajon, AE (reprint author), LRRI, Program Infect Dis, 2425 Ridgecrest Dr SE, Albuquerque, NM 87108 USA. EM akajon@lrri.org RI Valle, Ruben/A-7512-2013 FU Global Emerging Infections Surveillance and Response System; Division of the U.S. Armed Forces Health Surveillance Center; Henry M. Jackson Foundation for the Advancement of Military Medicine; Singapore Ministry of Defense FX Funding for this work was provided by the Global Emerging Infections Surveillance and Response System, a Division of the U.S. Armed Forces Health Surveillance Center, the Henry M. Jackson Foundation for the Advancement of Military Medicine, and the Singapore Ministry of Defense. We declare that no financial conflict of interest exists.; Views and opinions of and endorsements by the authors do not reflect those of the U.S. Army or the Department of Defense (DoD), the Department of the Navy, or the United States and Singapore governments. This research has been conducted in compliance with all applicable federal and international regulations governing the protection of human subjects in research (DoD protocol NHRC. 1999.0002). NR 36 TC 40 Z9 45 U1 0 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD APR PY 2010 VL 48 IS 4 BP 1438 EP 1441 DI 10.1128/JCM.01928-09 PG 4 WC Microbiology SC Microbiology GA 576OC UT WOS:000276153200064 PM 20129957 ER PT J AU Buono, MJ Martha, SL Heaney, JH AF Buono, Michael J. Martha, Sandra Leichliter Heaney, Jay H. TI Peripheral sweat gland function, but not whole-body sweat rate, increases in women following humid heat acclimation SO JOURNAL OF THERMAL BIOLOGY LA English DT Article DE Core temperature; Pilocarpine-induced sweat rate; Whole-body sweat rate ID DRY-HEAT; PHYSIOLOGICAL-RESPONSES; MEN; EXERCISE; STRESS; GENDER; SKIN AB The purpose of this study was to compare both the whole-body and pharmacological-induced sweat rates of men and women following humid heat acclimation. Whole-body sweat rate was significantly (P<0.05) increased 20% in men following heat acclimation; however, it was essentially unchanged in women. The most important new finding was that humid heat acclimation produced a significant (P<0.05) 60-70% increase in pilocarpine-induced sweat rate in both men and women. These results suggest that humid heat acclimation significantly improves peripheral sweat gland function equally in both men and women. However, during exercise in humid heat, the increased peripheral sweat capacity in women is suppressed via either pre- or post-glandular mechanisms, thus limiting wasteful sweat production. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Buono, Michael J.; Martha, Sandra Leichliter] San Diego State Univ, San Diego, CA 92182 USA. [Heaney, Jay H.] USN, Hlth Res Ctr, San Diego, CA 92106 USA. RP Buono, MJ (reprint author), San Diego State Univ, MC 7251, San Diego, CA 92182 USA. EM mbuono@mail.sdsu.edu NR 27 TC 2 Z9 2 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0306-4565 J9 J THERM BIOL JI J. Therm. Biol. PD APR PY 2010 VL 35 IS 3 BP 134 EP 137 DI 10.1016/j.jtherbio.2010.01.004 PG 4 WC Biology; Zoology SC Life Sciences & Biomedicine - Other Topics; Zoology GA 579MF UT WOS:000276374100004 ER PT J AU Mohr, SB Garland, CF Gorham, ED Grant, WB Garland, FC AF Mohr, Sharif B. Garland, Cedric F. Gorham, Edward D. Grant, William B. Garland, Frank C. TI Ultraviolet B Irradiance and Incidence Rates of Bladder Cancer in 174 Countries SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID VITAMIN-D SYNTHESIS; BREAST-CANCER; PLASMA 25-HYDROXYVITAMIN-D; SERUM 25-HYDROXYVITAMIN-D; POOLED ANALYSIS; OVARIAN-CANCER; HUMAN-SKIN; RISK; PREVENTION; SCHISTOSOMIASIS AB Background: Although nearly half of bladder cancer cases are due to smoking, the cause of nearly half is unexplained. Purpose: This study aims to determine whether an inverse association exists between ultraviolet B (UVB) irradiance and incidence rates of bladder cancer worldwide. Methods: This study used an ecologic approach. Age-adjusted incidence rates of bladder cancer from 2002 were obtained for all 174 countries in GLOBOCAN, a database of the International Agency for Research on Cancer. The relationship of latitude and estimated serum 25-hydroxyvitamin D [25(OH)D] with incidence rates was determined. The independent contributions to incidence rates of bladder cancer of UVB, per capita cigarette consumption in 1980, and per capita health expenditure for 2001 were assessed using multiple regression. The analyses were performed in July 2008. Results: Bladder cancer incidence rates were higher in countries at higher latitudes than those nearer to the equator (r=-0.66, 95% Cl=-0.74, -0.57, p<0.01). Ultraviolet B irradiance was independently inversely associated with incidence rates of bladder cancer after controlling for per capita cigarette consumption (beta=-0.28, 95% CI-0.51, -0.05; R(2) for model=0.38, p<0.0001). Further, UVB irradiance was also inversely associated with incidence rates after controlling for per capita health expenditure (beta=-0.23, 95% CI=-0.36, -0.01; R(2) for model=0.49, p<0.0001) in a separate regression model. Conclusions: Further investigation is needed to confirm the associations identified in this study using observational studies of individuals. The focus of this research should include the association of serum 25(OH)D levels with risk of bladder cancer. (Am J Prev Med 2010;38(3):296 -302) (C) 2010 American Journal of Preventive Medicine C1 [Mohr, Sharif B.; Garland, Cedric F.; Gorham, Edward D.; Garland, Frank C.] Univ Calif San Diego, Dept Family & Prevent Med, San Diego, CA 92103 USA. [Mohr, Sharif B.; Garland, Cedric F.; Gorham, Edward D.; Garland, Frank C.] USN, Hlth Res Ctr, Dept Hlth Sci & Epidemiol, San Diego, CA 92152 USA. [Grant, William B.] Sunlight Nutr & Hlth Res Ctr, San Francisco, CA USA. RP Garland, CF (reprint author), Univ Calif San Diego, Dept Family & Prevent Med, 9500 Gilman Dr, La Jolla, CA 92093 USA. EM cgarland@ucsd.edu RI Grant, William/B-8311-2009 OI Grant, William/0000-0002-1439-3285 FU Hollings Cancer Center of the Medical University of South Carolina; Charleston SC, through the Department of the Navy; Bureau of Medicine and Surgery [60126]; UV Foundation; Sunlight Research Forum; Bio-Tech-Pharmacal FX This research was supported by a congressional allocation to the Hollings Cancer Center of the Medical University of South Carolina, Charleston SC, through the Department of the Navy, Bureau of Medicine and Surgery, under Work Unit No. 60126. Thanks to the staff of the GLOBOCAN database of the International Agency for Research in Cancer of the WHO for providing the age-standardized data used in this study. Thanks also to the Columbia University Center for International Earth Science Information for providing the population centroids for each country that was used in this study.; The views expressed in this report are those of the authors and do not represent an official position of the Department of the Navy, Department of Defense, or the U.S. Government.; WBG receives funding from the UV Foundation (McLean VA), the Sunlight Research Forum (Veldhoven), and Bio-Tech-Pharmacal (Fayetteville AR), and has previously received funding from the Vitamin D Society (Canada). WBG has also received honoraria for presentations on vitamin D for cancer prevention. No other financial disclosures were reported by the authors of this paper. NR 51 TC 11 Z9 11 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD MAR PY 2010 VL 38 IS 3 BP 296 EP 302 DI 10.1016/j.amepre.2009.10.044 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 566OW UT WOS:000275383100007 PM 20171531 ER PT J AU Johnson, EC Ganio, MS Lee, EC Lopez, RM McDermott, BP Casa, DJ Maresh, CM Armstrong, LE AF Johnson, Evan C. Ganio, Matthew S. Lee, Elaine C. Lopez, Rebecca M. McDermott, Brendon P. Casa, Douglas J. Maresh, Carl M. Armstrong, Lawrence E. TI Perceptual Responses While Wearing an American Football Uniform in the Heat SO JOURNAL OF ATHLETIC TRAINING LA English DT Article DE rectal temperature; rating of perceived exertion; thermal perception; thirst perception; muscle pain perception ID PHYSIOLOGICAL-RESPONSES; FLUID INTAKE; MUSCLE PAIN; EXERCISE; BALANCE; REHYDRATION; INTENSITY; EQUIPMENT; HUMANS AB Context: The protective equipment worn during American football has been shown to increase thermal strain; however, the perception of this increased heat has not been examined. Objective: To evaluate perceptual responses of American football players while wearing different uniforms during exercise in the heat and to evaluate how these responses may be used to monitor athlete safety. Design: Randomized controlled trial. Setting: Human Performance Laboratory. Patients or Other Participants: Ten men with more than 3 years of competitive experience as football linemen (age 23.8 +/- 1.3 years, height 183.9 +/- 1.8 cm, mass = 117.4 +/- 3.5 kg, body fat = 30.1% +/- 1.7%) participated. Intervention(s): On 3 occasions in hot, humid (33 degrees C, 48%-49% relative humidity) environmental conditions, participants completed 10 minutes of strenuous repetitive box lifting (RBL), 10 minutes of seated rest, and up to 60 minutes of treadmill walking. At each trial, they wore a different uniform condition: control (CON) clothing comprising shorts, socks, and sneakers; partial (PART) National Football League (NFL) uniform comprising the uniform without helmet or shoulder pads; or full (FULL) NFL uniform. Exercise, meals, and hydration status were controlled. Main Outcome Measure(s): Rectal temperature (T(re)), skin temperature (T(sk)), rating of perceived exertion (RPE), thermal perception (THM), perception of thirst (TST), and perception of muscle pain (MPN) were obtained for time points matched across trials. Results: Nineteen of the 30 trials ended before 60 minutes of treadmill walking as a result of participant exhaustion. Mean treadmill time was longer for the CON condition (51.7 +/- 13.4 minutes) than for the PART (43.1 +/- 15.6 minutes; t(9) = 3.092, P = .01) or the FULL (36.2 +/- 13.2 minutes; t(9) = 4.393, P = .002) conditions. Neck and forearm T(sk) increased between the initial time point and the end of exercise in the PART (33.6 +/- 0.9 degrees C and 35.0 +/- 0.6 degrees C, respectively; F(2,18) = 9.034, P < .001) and the FULL (33.4 +/- 0.9 degrees C and 35.2 +/- 0.6 degrees C, respectively; F(2,18) = 21.011, P = .002) conditions. Rate of Tre rise was greater in the FULL (0.042 +/- 0.010 degrees C/min) than in the PART (0.034 +/- 0.006 degrees C/min) condition (F(2,27) = 10.69, P =.04). We found a relationship at the post-RBL and final time points between RPE and THM (r = 0.75, P < .001 and r = 0.59, P < .001, respectively), RPE and TST, (r = 0.76, P < .001 and r = 0.61, P < .001, respectively), and RPE and MPN (r = 0.63, P < .001 and r = 0.64, P < .001, respectively). The RPE was greater at the end of exercise in the PART (17 +/- 2) and FULL (18 +/- 1) conditions than in the CON (15 +/- 3) condition (F(2,18) 7.403, P = .005). Conclusions: Although no differences in perceptual scales existed between the PART and FULL conditions, the Tsk and rate of Tre increase differed, indicating that football athletes find it difficult to perceptually rate exercise conditions as potentially dangerous hyperthermia develops. In addition, correlations between the perceptual scales further defined perceptual responses during exercise in the heat. C1 [Johnson, Evan C.; Ganio, Matthew S.; Lee, Elaine C.; Lopez, Rebecca M.; McDermott, Brendon P.; Casa, Douglas J.; Maresh, Carl M.; Armstrong, Lawrence E.] Univ Connecticut, Dept Kinesiol, Storrs, CT USA. RP Johnson, EC (reprint author), USN, Hlth Res Ctr, Bldg 328,Room 207 C,140 Sylvester Rd, San Diego, CA 92106 USA. EM Evan.Johnson@med.navy.mil FU Waite; Schneider; Bayless; Chesley (Cincinnati, OH) FX This investigation was funded in part by Waite, Schneider, Bayless & Chesley (Cincinnati, OH). NR 35 TC 13 Z9 15 U1 2 U2 6 PU NATL ATHLETIC TRAINERS ASSOC INC PI DALLAS PA 2952 STEMMONS FREEWAY, DALLAS, TX 75247 USA SN 1062-6050 J9 J ATHL TRAINING JI J. Athl. Train. PD MAR-APR PY 2010 VL 45 IS 2 BP 107 EP 116 DI 10.4085/1062-6050-45.2.107 PG 10 WC Sport Sciences SC Sport Sciences GA 573PS UT WOS:000275927300002 PM 20210614 ER PT J AU Seah, SGK Lim, EAS Kok-Yong, S Liaw, JCW Lee, V Kammerer, P Metzgar, D Russell, KL Tan, BH AF Seah, Shirley Gek-Kheng Lim, Elizabeth Ai-Sim Kok-Yong, Seng Liaw, Jasper Chin-Wen Lee, Vernon Kammerer, Peter Metzgar, David Russell, Kevin L. Tan, Boon-Huan TI Viral agents responsible for febrile respiratory illnesses among military recruits training in tropical Singapore SO JOURNAL OF CLINICAL VIROLOGY LA English DT Article DE Singapore military; Tropical; Influenza A and B viruses; Febrile respiratory illness; Recruits ID POLYMERASE-CHAIN-REACTION; HEALTHY-YOUNG ADULTS; INFLUENZA-A; PCR ASSAY; ADENOVIRUS; DISEASE; VIRUS; OUTBREAK; INFECTIONS; EMERGENCE AB Background: Military personnel are highly susceptible to febrile respiratory illnesses (FRI), likely due to crowding, stress and other risk factors present in the military environment. Objective: Our objective was to investigate the viral etiological agents responsible for FRI among military recruits training in a tropical climate in Singapore. Study design: From March 2006 through April 2007, a total of 1354 oropharyngeal (throat) swabs were collected from military recruits who reported sick with an oral temperature of >= 38 degrees C and a cough and/or sore throat. Real-time polymerase chain reaction (PCR) was used to assay for the presence of influenza A and B viruses and adenoviruses (H-AdV), and conventional PCR used for the remaining respiratory viruses in all specimens. Results: Influenza A virus was the dominant infection with a laboratory-confirmed incidence of 24% (326/1354) and a predominance of the H3N2 subtype. The temporal pattern for influenza A virus infections coincided with the nation-wide pattern in the civilian community. Detection rates of 12% (159/1354) and 2.7% (5/1354) were obtained for influenza B virus and other respiratory viruses, respectively. Conclusions: The laboratory findings identified influenza A virus as the primary causative viral agent for FRI in the Singapore military, in strong contrast to findings from temperate countries and countries where recruits are often vaccinated for influenza. Our results suggest that influenza vaccination should be considered as a requirement to reduce the incidence of influenza infections. This is the first report describing respiratory infections in a tropical military setting, in a developed country in Asia. (C) 2010 Elsevier B.V. All rights reserved. C1 [Seah, Shirley Gek-Kheng; Lim, Elizabeth Ai-Sim; Kok-Yong, Seng; Liaw, Jasper Chin-Wen; Tan, Boon-Huan] DSO Natl Labs, Detect & Diagnost Lab, Singapore 117510, Singapore. [Lee, Vernon] Singapore Armed Forces, Biodef Ctr, Headquarters Med Corps, Singapore, Singapore. [Kammerer, Peter; Metzgar, David; Russell, Kevin L.] USN, Hlth Res Ctr, Dept Resp Dis Res, San Diego, CA 92152 USA. RP Tan, BH (reprint author), DSO Natl Labs, Detect & Diagnost Lab, 13-00,27 Med Dr,DSO Kent Ridge Bldg, Singapore 117510, Singapore. EM tboonhua@dso.org.sg RI Valle, Ruben/A-7512-2013 FU Ministry of Defence, Singapore FX This research is funded by Ministry of Defence, Singapore. NR 32 TC 13 Z9 13 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1386-6532 EI 1873-5967 J9 J CLIN VIROL JI J. Clin. Virol. PD MAR PY 2010 VL 47 IS 3 BP 289 EP 292 DI 10.1016/j.jcv.2009.12.011 PG 4 WC Virology SC Virology GA 559XI UT WOS:000274862700020 PM 20079688 ER PT J AU Melcer, T Walker, GJ Galarneau, M Belnap, B Konoske, P AF Melcer, Ted Walker, G. Jay Galarneau, Michael Belnap, Brian Konoske, Paula TI Midterm Health and Personnel Outcomes of Recent Combat Amputees SO MILITARY MEDICINE LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; OPERATION ENDURING FREEDOM; TRAUMATIC BRAIN-INJURY; FOLLOW-UP; HETEROTOPIC OSSIFICATION; MILITARY PERSONNEL; IRAQI-FREEDOM; VIETNAM-WAR; AMPUTATIONS; AFGHANISTAN AB Objective: Warfighters who sustained combat amputations in Operation Enduring Freedom or Operation Iraqi Freedom (OEF/OIF) have unique challenges during rehabilitation. This study followed their outcomes. Methods: Subjects were 382 U.S. warfighters with major limb amputations utter combat injury in OEF/OIF between 2001 and 2005. Outcome measures were diagnoses, treatment codes, and personnel events captured by health and personnel data-bases during 24 months postinjury. Results: Most patients had multiple complications generally within 30 days postinjury (e.g., infections, anemia), with important exceptions (e.g., heterotopic ossification). Lower limb amputees had 50% more complications than upper limb amputees. Two-thirds of patients had a mental health disorder (e.g.. adjustment, post-traumatic stress disorder), with rates of major disorder categories between 18% and 25%. Over 80% of patients used physical and occupational therapy. prosthetic/orthotic services. and psychiatric care. Conclusions: Combat amputees had a complex set of outcomes supporting the continued need for military amputee care programs. C1 [Melcer, Ted; Galarneau, Michael; Konoske, Paula] USN, Hlth Res Ctr, San Diego, CA 92106 USA. [Walker, G. Jay] Sci Applicat Int Corp, San Diego, CA 92121 USA. [Belnap, Brian] USN, San Diego Med Ctr, Comprehens Combat & Complex Casualty Care Naval M, San Diego, CA 92134 USA. RP Melcer, T (reprint author), USN, Hlth Res Ctr, Dept 161,Bldg 331,140 Sylvester Rd, San Diego, CA 92106 USA. FU Office of the Assistant Secretary of Defense (Health Affairs); U.S. Army Medical Research and Materiel Command; Marine Corps Systems Command; Office of Naval Research FX This work was funded by the Office of the Assistant Secretary of Defense (Health Affairs), U.S. Army Medical Research and Materiel Command, Marine Corps Systems Command, and the Office of Naval Research. NR 40 TC 27 Z9 27 U1 0 U2 9 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2010 VL 175 IS 3 BP 147 EP 154 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 582GT UT WOS:000276585400005 PM 20358702 ER PT J AU Nguyen, JT Hoopes, JD Le, MH Smee, DF Patick, AK Faix, DJ Blair, PJ de Jong, MD Prichard, MN Went, GT AF Nguyen, Jack T. Hoopes, Justin D. Le, Minh H. Smee, Donald F. Patick, Amy K. Faix, Dennis J. Blair, Patrick J. de Jong, Menno D. Prichard, Mark N. Went, Gregory T. TI Triple Combination of Amantadine, Ribavirin, and Oseltamivir Is Highly Active and Synergistic against Drug Resistant Influenza Virus Strains In Vitro SO PLOS ONE LA English DT Article ID A H1N1 VIRUSES; NEURAMINIDASE INHIBITORS; HEMAGGLUTININ GLYCOPROTEIN; CELL-CULTURE; MDCK CELLS; APRIL 2009; MICE; INFECTIONS; SURVEILLANCE; WORLDWIDE AB The rapid emergence and subsequent spread of the novel 2009 Influenza A/H1N1 virus (2009 H1N1) has prompted the World Health Organization to declare the first pandemic of the 21(st) century, highlighting the threat of influenza to public health and healthcare systems. Widespread resistance to both classes of influenza antivirals (adamantanes and neuraminidase inhibitors) occurs in both pandemic and seasonal viruses, rendering these drugs to be of marginal utility in the treatment modality. Worldwide, virtually all 2009 H1N1 and seasonal H3N2 strains are resistant to the adamantanes (rimantadine and amantadine), and the majority of seasonal H1N1 strains are resistant to oseltamivir, the most widely prescribed neuraminidase inhibitor (NAI). To address the need for more effective therapy, we evaluated the in vitro activity of a triple combination antiviral drug (TCAD) regimen composed of drugs with different mechanisms of action against drug-resistant seasonal and 2009 H1N1 influenza viruses. Amantadine, ribavirin, and oseltamivir, alone and in combination, were tested against amantadine-and oseltamivir-resistant influenza A viruses using an in vitro infection model in MDCK cells. Our data show that the triple combination was highly synergistic against drug-resistant viruses, and the synergy of the triple combination was significantly greater than the synergy of any double combination tested (P < 0.05), including the combination of two NAIs. Surprisingly, amantadine and oseltamivir contributed to the antiviral activity of the TCAD regimen against amantadine-and oseltamivir-resistant viruses, respectively, at concentrations where they had no activity as single agents, and at concentrations that were clinically achievable. Our data demonstrate that the TCAD regimen composed of amantadine, ribavirin, and oseltamivir is highly synergistic against resistant viruses, including 2009 H1N1. The TCAD regimen overcomes baseline drug resistance to both classes of approved influenza antivirals, and thus may represent a highly active antiviral therapy for seasonal and pandemic influenza. C1 [Nguyen, Jack T.; Le, Minh H.; Patick, Amy K.; Went, Gregory T.] Adamas Pharmaceut Inc, Emeryville, CA USA. [Hoopes, Justin D.; Smee, Donald F.] Utah State Univ, Logan, UT 84322 USA. [Faix, Dennis J.; Blair, Patrick J.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [de Jong, Menno D.] Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands. [Prichard, Mark N.] Univ Alabama, Birmingham, AL USA. RP Nguyen, JT (reprint author), Adamas Pharmaceut Inc, Emeryville, CA USA. EM jnguyen@adamaspharma.com; gwent@adamaspharma.com FU Adamas Pharmaceuticals FX Funding for this study was provided by Adamas Pharmaceuticals. Authors from Adamas Pharmaceuticals participated in the design of the studies, analysis of the data, and preparing the manuscript. NR 40 TC 88 Z9 92 U1 1 U2 16 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 22 PY 2010 VL 5 IS 2 AR e9332 DI 10.1371/journal.pone.0009332 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 560SU UT WOS:000274923900006 PM 20179772 ER PT J AU Landrum, ML Hullsiek, KH Ganesan, A Weintrob, AC Crum-Cianflone, NF Barthel, RV O'Connell, RJ Fieberg, A Chun, HM Marconi, VC Dolan, MJ Agan, BK AF Landrum, Michael L. Hullsiek, Katherine Huppler Ganesan, Anuradha Weintrob, Amy C. Crum-Cianflone, Nancy F. Barthel, R. Vincent O'Connell, Robert J. Fieberg, Ann Chun, Helen M. Marconi, Vincent C. Dolan, Matthew J. Agan, Brian K. CA Infect Dis Clinical Res Program TI Hepatitis B vaccination and risk of hepatitis B infection in HIV-infected individuals SO AIDS LA English DT Article DE hepatitis B vaccine; hepatitis B virus; human immunodeficiency virus; immunization; vaccination ID HUMAN-IMMUNODEFICIENCY-VIRUS; LONG-TERM IMMUNOGENICITY; T-CELL RESPONSES; HOMOSEXUAL-MEN; ANTIRETROVIRAL THERAPY; UNITED-STATES; EFFICACY; ANTIBODY; COHORT; TRIAL AB Objective: To assess the association of hepatitis B virus (HBV) vaccination with risk of HBV infection among HIV-infected patients and HBV infection risk factors among vaccinees. Design: Observational cohort study. Methods: Participants enrolled from 1986 through 2004, unvaccinated and serologically negative for HBV infection at the time of HIV diagnosis, were followed longitudinally through 2007 for the occurrence of HBV infection. Risk factors for HBV infection were evaluated using time to event methods, including Kaplan-Meier survival curves and Cox proportional hazards models. Results: During 11 632 person-years of follow-up, the rate of HBV infection was 2.01 (95% CI 1.75-2.27)/100 person-years. Receipt of at least one dose of vaccine was not associated with reduced risk of HBV (unadjusted hazard ratio 0.86, 95% CI 0.7-1.1; adjusted hazard ratio 1.08, 95% CI 0.8-1.4). Receipt of three or more doses of vaccine was also not associated with reduced risk (hazard ratio 0.96; 95% CI 0.56-1.64). Among 409 vaccinees with HBsAb less than 10 IU/l, 46 (11.2%) developed HBV infection compared with 11 of 217 (5.1%) vaccinees with HBsAb >= 10 IU/l (hazard ratio 0.51; 95% CI 0.3-1.0). In participants with initial HBsAb less than 10 IU/l, 16 of 46 (35%) infections were chronic, compared with none of 11 in those with initial HBsAb at least 10 IU/l (P = 0.02). Conclusion: Overall, HBV vaccination was not associated with reduced risk of HBV infection in our cohort of HIV-infected individuals. However, the small subset of vaccinees with a positive vaccine response may have had reduced HBV infection risk, including chronic disease. Improvements in vaccine delivery and immunogenicity are needed to increase HBV vaccine effectiveness in HIV-infected patients. (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins C1 [Landrum, Michael L.; Marconi, Vincent C.; Dolan, Matthew J.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Landrum, Michael L.; Hullsiek, Katherine Huppler; Ganesan, Anuradha; Weintrob, Amy C.; Crum-Cianflone, Nancy F.; O'Connell, Robert J.; Fieberg, Ann; Marconi, Vincent C.; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD USA. [Hullsiek, Katherine Huppler; Fieberg, Ann] Univ Minnesota, Minneapolis, MN USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Bethesda, MD USA. [Weintrob, Amy C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Crum-Cianflone, Nancy F.] Naval Med Ctr, San Diego, CA USA. [Barthel, R. Vincent] Naval Med Ctr, Portsmouth, VA USA. [O'Connell, Robert J.] Walter Reed Army Inst Res, Div Retrovirol, Silver Spring, MD USA. [Chun, Helen M.] Naval Hlth Res Ctr, San Diego, CA USA. RP Landrum, ML (reprint author), Brooke Army Med Ctr, Infect Dis Serv, MCHE MDI, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM mlandrum@idcrp.org RI Marconi, Vincent/N-3210-2014; OI Marconi, Vincent/0000-0001-8409-4689; Agan, Brian/0000-0002-5114-1669 FU NIAID NIH HHS [HU0001-05-2-0011]; PHS HHS [HU0001-05-2-0011] NR 54 TC 25 Z9 25 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0269-9370 J9 AIDS JI Aids PD FEB 20 PY 2010 VL 24 IS 4 BP 545 EP 555 DI 10.1097/QAD.0b013e32832cd99e PG 11 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 563QK UT WOS:000275148000007 PM 19487908 ER PT J AU Guenthner, AJ Hess, DM Cash, JJ AF Guenthner, Andrew J. Hess, David M. Cash, Jessica J. TI Dimensional Stability of Sparse Network Microstructures Formed by Photopolymerization-Induced Phase Separation SO JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS LA English DT Article DE microstructure; morphology; phase separation; thiol-ene ID DISPERSED LIQUID-CRYSTAL; LATEX FILM FORMATION; IMMISCIBLE POLYMER BLENDS; LOW-REYNOLDS-NUMBER; MORPHOLOGY DEVELOPMENT; POLYSULFONE MEMBRANES; INTERFACIAL-TENSION; TERNARY-SYSTEM; WATER; SCAFFOLDS AB The morphology of sparse filament networks formed during photo polymerization-induced phase separation of mixtures of NOA81 (a UV-curable thiol-ene adhesive) in mixed cosolvents consisting of water, diglyme, and polyethers of varying molecular weight was investigated as a function of the molecular weight and relative amount of the polyethers used. During photo polymerization (50 mW/cm(-2) of 365 nm radiation for 60 s) of solutions containing 5 wt % NOA81 and a total oligo-ether or polyether to water ratio of 8:1 by weight, viscoelastic phase separation produced a sparse network of interconnected NOA81 filaments. During the subsequent evaporation and/or solidification of the solvents, the network compacted significantly via a collapse process that was curtailed by increasing both the weight fraction and molecular weight of the nonvolatile polyether. The influence of mass and momentum transport processes on the collapse of the phase-separated network and the resultant final morphology was determined with the aid of dimensional analysis, leading to the identification of sedimentation and compaction driven by the motion of the interface as key factors. The networks exhibiting the least collapse combine a high level of interconnectivity and specific surface area with a low occupied volume fraction while being fabricated via a simple, template-free process. (C) 2010 Wiley Periodicals, Inc.* J Polym Sci Part B: Polym Phys 48: 396-410, 2010 C1 [Guenthner, Andrew J.; Hess, David M.; Cash, Jessica J.] USN, Air Warfare Ctr, Weap Div, China Lake, CA 93555 USA. RP Guenthner, AJ (reprint author), USN, Air Warfare Ctr, Weap Div, China Lake, CA 93555 USA. EM andrew.guenthner@navy.mil FU Office of Naval Research; American Society of Engineering Education FX The support of the Office of Naval Research is gratefully acknowledged. D. M. Hess thanks the American Society of Engineering Education for support through the Navy Research Laboratory Post-Doctoral Fellowship Program. The efforts of Danielle Ramos and Dan Connor in producing the SEM images and corresponding element maps are also greatly appreciated. NR 51 TC 0 Z9 0 U1 3 U2 16 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0887-6266 EI 1099-0488 J9 J POLYM SCI POL PHYS JI J. Polym. Sci. Pt. B-Polym. Phys. PD FEB 15 PY 2010 VL 48 IS 4 BP 396 EP 410 DI 10.1002/polb.21868 PG 15 WC Polymer Science SC Polymer Science GA 558NR UT WOS:000274751200002 ER PT J AU Metzgar, D Myers, CA Russell, KL Faix, D Blair, PJ Brown, J Vo, S Swayne, DE Thomas, C Stenger, DA Lin, B Malanoski, AP Wang, Z Blaney, KM Long, NC Schnur, JM Saad, MD Borsuk, LA Lichanska, AM Lorence, MC Weslowski, B Schafer, KO Tibbetts, C AF Metzgar, David Myers, Christopher A. Russell, Kevin L. Faix, Dennis Blair, Patrick J. Brown, Jason Vo, Scott Swayne, David E. Thomas, Colleen Stenger, David A. Lin, Baochuan Malanoski, Anthony P. Wang, Zheng Blaney, Kate M. Long, Nina C. Schnur, Joel M. Saad, Magdi D. Borsuk, Lisa A. Lichanska, Agnieszka M. Lorence, Matthew C. Weslowski, Brian Schafer, Klaus O. Tibbetts, Clark TI Single Assay for Simultaneous Detection and Differential Identification of Human and Avian Influenza Virus Types, Subtypes, and Emergent Variants SO PLOS ONE LA English DT Article ID RESEQUENCING DNA MICROARRAYS; PATHOGEN IDENTIFICATION; BACTERIAL PNEUMONIA; PANDEMIC INFLUENZA; BROAD-SPECTRUM; HEMAGGLUTININ; SURVEILLANCE; TOOL AB For more than four decades the cause of most type A influenza virus infections of humans has been attributed to only two viral subtypes, A/H1N1 or A/H3N2. In contrast, avian and other vertebrate species are a reservoir of type A influenza virus genome diversity, hosting strains representing at least 120 of 144 combinations of 16 viral hemagglutinin and 9 viral neuraminidase subtypes. Viral genome segment reassortments and mutations emerging within this reservoir may spawn new influenza virus strains as imminent epidemic or pandemic threats to human health and poultry production. Traditional methods to detect and differentiate influenza virus subtypes are either time-consuming and labor-intensive (culture-based) or remarkably insensitive (antibody-based). Molecular diagnostic assays based upon reverse transcriptase-polymerase chain reaction (RT-PCR) have short assay cycle time, and high analytical sensitivity and specificity. However, none of these diagnostic tests determine viral gene nucleotide sequences to distinguish strains and variants of a detected pathogen from one specimen to the next. Decision-quality, strain-and variant-specific pathogen gene sequence information may be critical for public health, infection control, surveillance, epidemiology, or medical/veterinary treatment planning. The Resequencing Pathogen Microarray (RPM-Flu) is a robust, highly multiplexed and target gene sequencing-based alternative to both traditional culture-or biomarker-based diagnostic tests. RPM-Flu is a single, simultaneous differential diagnostic assay for all subtype combinations of type A influenza viruses and for 30 other viral and bacterial pathogens that may cause influenza-like illness. These other pathogen targets of RPM-Flu may co-infect and compound the morbidity and/or mortality of patients with influenza. The informative specificity of a single RPM-Flu test represents specimen-specific viral gene sequences as determinants of virus type, A/HN subtype, virulence, host-range, and resistance to antiviral agents. C1 [Metzgar, David; Myers, Christopher A.; Russell, Kevin L.; Faix, Dennis; Blair, Patrick J.; Brown, Jason; Vo, Scott] USN, Dept Resp Dis Res, Hlth Res Ctr, San Diego, CA 92152 USA. [Russell, Kevin L.] US Dept Def Global Emerging Infect Surveillance &, Div Armed Forces Hlth Surveillance Ctr, Silver Spring, MD USA. [Swayne, David E.; Thomas, Colleen; Blaney, Kate M.] ARS, SE Poultry Res Lab, USDA, Athens, GA USA. [Stenger, David A.; Lin, Baochuan; Malanoski, Anthony P.; Wang, Zheng; Long, Nina C.; Schnur, Joel M.] USN, Res Lab, Ctr Bio Mol Sci & Engn, Washington, DC 20375 USA. [Schnur, Joel M.] George Mason Univ, Manassas, VA USA. [Saad, Magdi D.] Naval Med Res Unit 3, Cairo, Egypt. [Borsuk, Lisa A.; Lichanska, Agnieszka M.; Lorence, Matthew C.; Weslowski, Brian; Schafer, Klaus O.; Tibbetts, Clark] TessArae LLC, Potomac Falls, VA USA. RP Metzgar, D (reprint author), USN, Dept Resp Dis Res, Hlth Res Ctr, San Diego, CA 92152 USA. EM clark.tibbetts@tessarae.com RI Malanoski, Anthony/C-7814-2011; Saad, Magdi/H-5561-2013; Valle, Ruben/A-7512-2013; Lin, Baochuan/A-8390-2009 OI Malanoski, Anthony/0000-0001-6192-888X; Saad, Magdi/0000-0003-2111-8115; Lin, Baochuan/0000-0002-9484-0785 FU TessArae [NCRADA-NRL-06-406]; United States Navy to TessArae [N00244-07-C-0037]; Department of Defense; Division of the Armed Forces Health Surveillance Center, Silver Spring, Maryland FX No grant funding supported this effort. TessArae and the Naval Research Laboratory worked together under a Cooperative Research and Development Agreement (NCRADA-NRL-06-406), with financial resources contributed from TessArae. TessArae and the Naval Health Research Center worked together under a research services contract (N00244-07-C-0037) from the United States Navy to TessArae. Partial funding for this respiratory disease surveillance initiative was provided by the Department of Defense, Global Emerging Infections Surveillance and Response System (GEIS), a Division of the Armed Forces Health Surveillance Center, Silver Spring, Maryland. TessArae and the Department of Agriculture, Agricultural Research Service, Southeast Poultry Research Laboratory (SEPRL) cooperated under a no-cost cooperative agreement under which SEPRL provided samples (as their respective costs assumed) for testing and TessArae performed the testing (as their respective costs assumed). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 27 TC 22 Z9 28 U1 2 U2 8 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 3 PY 2010 VL 5 IS 2 AR e8995 DI 10.1371/journal.pone.0008995 PG 18 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 554ZA UT WOS:000274474200003 PM 20140251 ER PT J AU Cranston, MM Ryan, MAK Smith, TC Sevick, CJ Brodine, SK AF Cranston, Marcus M. Ryan, Margaret A. K. Smith, Tyler C. Sevick, Carter J. Brodine, Stephanie K. TI Hypothyroidism among military infants born in countries of varied iodine nutrition status SO BMC ENDOCRINE DISORDERS LA English DT Article ID CONGENITAL HYPOTHYROIDISM; UNITED-STATES; URINARY IODINE; SCREENING-PROGRAM; NATIONAL-HEALTH; RISK-FACTORS; PREGNANCY; PREVALENCE; ETHNICITY AB Background: Iodine deficiency is a global problem representing the most common preventable cause of mental retardation. Recently, the impact of subtle deficiencies in iodine intake on children and pregnant women has been questioned. This study was designed to compare hypothyroidism among infants born to US military families in countries of varied iodine nutrition status. Methods: A cohort design was used to analyze data from the Department of Defense Birth and Infant Health Registry for infants born in 2000-04 (n = 447,691). Hypothyroidism was defined using ICD-9-CM codes from the first year of life (n = 698). The impact of birth location on hypothyroidism was assessed by comparing rates in Germany, Japan, and US territories with the United States, while controlling for infant gender, plurality, gestational age, maternal age, maternal military status, and military parent's race/ethnicity. Results: Hypothyroidism did not vary by birth location with adjusted odds ratios (OR) as follows: Germany (OR 0.82, [95% CI 0.50, 1.35]), Japan (OR 0.67, [95% CI 0.37, 1.22]), and US territories (OR 1.29, [95% CI 0.57, 2.89]). Hypothyroidism was strongly associated with preterm birth (OR 5.44, [95% CI 4.60, 6.42]). Hypothyroidism was also increased among infants with civilian mothers (OR 1.24, [95% CI 1.00, 1.54]), and older mothers, especially ages 40 years and older (OR 2.09, [95% CI 1.33, 3.30]). Conclusions: In this study, hypothyroidism in military-dependent infants did not vary by birth location, but was associated with other risk factors, including preterm birth, civilian maternal status, and advanced maternal age. C1 [Smith, Tyler C.; Sevick, Carter J.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Cranston, Marcus M.] Keesler Med Ctr, Keesler AFB, MS USA. [Ryan, Margaret A. K.] USN Hosp, Camp Pendleton, CA USA. [Brodine, Stephanie K.] San Diego State Univ, San Diego, CA 92182 USA. RP Smith, TC (reprint author), USN, Hlth Res Ctr, San Diego, CA 92152 USA. EM tyler.c.smith@med.navy.mil FU Department of Defense [60504] FX This represents report 08-16, supported by the Department of Defense, under work unit no. 60504. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of the Army, Department of the Air Force, Department of Defense, or the US Government. This research has been conducted in compliance with all applicable federal regulations governing the protection of human subjects in research (Protocol NHRC.2007.0026). NR 24 TC 1 Z9 1 U1 0 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1472-6823 J9 BMC ENDOCR DISORD JI BMC Endocr. Disord. PD FEB 1 PY 2010 VL 10 AR 2 DI 10.1186/1472-6823-10-2 PG 6 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 851KV UT WOS:000297269200001 PM 20205833 ER PT J AU Chun, HM Fieberg, AM Hullsiek, KH Lifson, AR Crum-Cianflone, NF Weintrob, AC Ganesan, A Barthel, RV Bradley, WP Agan, BK Landrum, ML AF Chun, Helen M. Fieberg, Ann M. Hullsiek, Katherine Huppler Lifson, Alan R. Crum-Cianflone, Nancy F. Weintrob, Amy C. Ganesan, Anuradha Barthel, Robert V. Bradley, William P. Agan, Brian K. Landrum, Michael L. CA HIV Working Grp TI Epidemiology of Hepatitis B Virus Infection in a US Cohort of HIV-Infected Individuals during the Past 20 Years SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; ACTIVE ANTIRETROVIRAL THERAPY; UNITED-STATES; RISK-FACTORS; C VIRUS; HEPATOTOXICITY; PREVALENCE; RECOMMENDATIONS; ANTIBODIES; MANAGEMENT AB Background. The epidemiologic trends of hepatitis B virus (HBV) infection in human immunodeficiency virus (HIV)-infected patients over the past 20 years are largely unknown. Methods. Prevalence and risk factors for HBV infection overall, at the time of HIV infection, and after HIV infection were examined in an ongoing observational HIV cohort study. Risk factors for HBV infection at the time of diagnosis of HIV infection were evaluated using logistic regression, and risk of incident HBV infection after diagnosis of HIV infection was evaluated using Cox proportional hazards models. Results. Of the 2769 evaluable participants, 1078 (39%) had HBV infection, of whom 117 (11%) had chronic HBV infection. The yearly cross-sectional prevalence of HBV infection decreased from a peak of 49% in 1995 to 36% in 2008 (P < .001). The prevalence of HBV infection at the time of diagnosis of HIV infection decreased during 1989-2008 from 34% to 9% (P < .001). The incidence of HBV infection after diagnosis of HIV infection decreased from 4.0 cases per 100 person-years during the pre-highly active antiretroviral therapy (HAART) era to 1.1 cases per 100 person-years during the HAART era (P < .001); however, this incidence remained unchanged during 2000-2008 (P = .49), with 120% of HBV infections occurring after HIV infection being chronic. Decreased risk of HBV infection after diagnosis of HIV infection was associated with higher CD4 cell count and the use of HBV-active HAART. Receipt of >= 1 dose of HBV vaccine was not associated with reduced risk of HBV infection after diagnosis of HIV infection. Conclusions. Although the burden of HBV infection overall is slowly decreasing among HIV-infected individuals, the persistent rate of HBV infection after diagnosis of HIV infection raises concern that more-effective prevention strategies may be needed to significantly reduce the prevalence of HBV infection in this patient population. C1 [Chun, Helen M.] Naval Hlth Res Ctr, San Diego, CA USA. [Crum-Cianflone, Nancy F.] Naval Med Ctr San Diego, San Diego, CA USA. [Fieberg, Ann M.; Hullsiek, Katherine Huppler; Lifson, Alan R.] Univ Minnesota, Minneapolis, MN USA. [Fieberg, Ann M.; Hullsiek, Katherine Huppler; Lifson, Alan R.; Crum-Cianflone, Nancy F.; Weintrob, Amy C.; Ganesan, Anuradha; Bradley, William P.; Agan, Brian K.; Landrum, Michael L.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Bethesda, MD USA. [Weintrob, Amy C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Barthel, Robert V.] Naval Med Ctr Portsmouth, Portsmouth, VA USA. [Bradley, William P.; Landrum, Michael L.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. RP Landrum, ML (reprint author), Brooke Army Med Ctr, MCHE MDI, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM mlandrum@idcrp.org RI Marconi, Vincent/N-3210-2014; OI Marconi, Vincent/0000-0001-8409-4689; Agan, Brian/0000-0002-5114-1669 FU Uniformed Services University of the Health Sciences (USUHS); Department of Defence; Henry M. Jackson Foundation; National Institutes of Health, National Institute of Allergy and Infectious Diseases [HU0001-05-2-0011] FX Infectious Disease Clinical Research Program (IDCRP) of the Uniformed Services University of the Health Sciences (USUHS). The IDCRP is a Department of Defence tri-service program executed through USUHS and the Henry M. Jackson Foundation for the Advancement of Military Medicine, in collaboration with Health and Human Services, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Division of Clinical Research through Interagency Agreement HU0001-05-2-0011. NR 38 TC 28 Z9 30 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD FEB 1 PY 2010 VL 50 IS 3 BP 426 EP 436 DI 10.1086/649885 PG 11 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 542NG UT WOS:000273500300019 PM 20047484 ER PT J AU Woodruff, SI Dougherty, AL Dye, JL Mohrle, CR Galarneau, MR AF Woodruff, Susan I. Dougherty, Amber L. Dye, Judy L. Mohrle, Charlene R. Galarneau, Michael R. TI Use of recombinant factor VIIA for control of combat-related haemorrhage SO EMERGENCY MEDICINE JOURNAL LA English DT Article ID ACTIVATED FACTOR-VII; INJURY SEVERITY SCORE; V LIVER INJURIES; DAMAGE-CONTROL; TRAUMA; COAGULOPATHY; RFVIIA; CARE; TRANSFUSION; CASUALTIES AB Background Recombinant activated human coagulation factor VII (rFVIIa), an intravascular strategy to promote clotting, is being used as an adjunct to surgical control of bleeding in combat trauma patients. Objective To describe the initial experiences with rFVIIa administered to combat casualties at US Navy-Marine Corps medical treatment facilities in Iraq, and to compare survival outcomes of those treated with rFVIIa to controls not receiving rFVIIa. Methods Medical encounter data from the US Navy-Marine Corps Combat Trauma Registry were retrospectively reviewed to identify all battle-injured patients documented as having received rFVIIa during the period May 2004 to January 2006 of Operation Iraqi Freedom. Available clinical and injury related data are presented to characterise the patients. To assess effects of rFVIIa on survival outcomes, rFVIIa cases were matched to controls on injury severity and age. Results 22 battle-injured patients from the Combat Trauma Registry received rFVIIa. Primarily young US Marines, these patients typically had penetrating injuries from improvised explosive devices and gunshot wounds. Injuries were often abdominal. The average dose used was similar to that reported in another study of civilian trauma patients, although dosing varies widely in the existing experimental and anecdotal literature. Over two-thirds (68%) of the rFVIIa patients survived-an identical outcome seen for a matched control group of 22 patients. Conclusions Survival of seriously injured combat casualties was good, although identical to that of a control group. Methodological limitations of this retrospective study preclude making firm conclusions about the effectiveness of rFVIIa. Future controlled studies are needed for safety and efficacy testing of rFVIIa in combat trauma patients. C1 [Dougherty, Amber L.; Galarneau, Michael R.] USN, Hlth Res Ctr, Dept Med Modeling Simulat & Mission Support, San Diego, CA 92106 USA. [Dye, Judy L.; Mohrle, Charlene R.] Sci Applicat Int Corp, Hlth Solut Business Unit, San Diego, CA USA. [Woodruff, Susan I.] San Diego State Univ, Sch Social Work, San Diego, CA 92182 USA. RP Dougherty, AL (reprint author), USN, Hlth Res Ctr, Dept Med Modeling Simulat & Mission Support, 140 Sylvester Rd, San Diego, CA 92106 USA. EM amber.dougherty@med.navy.mil FU US Navy Bureau of Medicine and Surgery, Washington, DC FX This research was supported by the US Navy Bureau of Medicine and Surgery, Washington, DC under Work Unit No. 60332. The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense or the US Government. Approved for public release; distribution is unlimited.; NHRC certifies that this research has been conducted in compliance with all applicable federal regulations governing the protection of human subjects in research (# NHRC-2003-0025). NR 28 TC 9 Z9 9 U1 0 U2 2 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1472-0205 J9 EMERG MED J JI Emerg. Med. J. PD FEB PY 2010 VL 27 IS 2 BP 121 EP 124 DI 10.1136/emj.2008.060657 PG 4 WC Emergency Medicine SC Emergency Medicine GA 555MK UT WOS:000274514700011 PM 20156864 ER PT J AU Asvestas, JS Yankovich, SP Allen, OE AF Asvestas, John S. Yankovich, Stephen Paul Allen, Oliver Eric TI Calculation of the Impedance Matrix Inner Integral to Prescribed Precision SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Article DE Boundary-integral equations; cubatures; Gordon-Bilow transformation; impedance-matrix; method of moments (MoM); numerical integration; significant digits; Taylor's theorem with a remainder ID POTENTIAL INTEGRALS; ELEMENTS; ACCURATE AB We present a new method for evaluating the inner integral of the impedance matrix element in the traditional Rao-Wilton-Glisson formulation of the method of moments for perfect conductors. In this method we replace the original integrand (modified by a constant phase factor) by its Taylor series and keep enough terms to guarantee a number of significant digits in the integration outcome. We develop criteria that relate the number of Taylor terms to the number of required significant digits. We integrate the leading Taylor terms analytically and the rest through iteration formulas. We show that the iteration formulas converge for all observation points within a sphere with a radius of half-a-wavelength and center the triangle's centroid. We compare results of our method with existing ones and find them in excellent agreement. We also outline a procedure for using cubatures outside the region of convergence. C1 [Asvestas, John S.; Yankovich, Stephen Paul; Allen, Oliver Eric] NAVAIR, Radar & Antenna Syst Div, Patuxent River, MD 20670 USA. RP Asvestas, JS (reprint author), NAVAIR, Radar & Antenna Syst Div, Code 4-5-5, Patuxent River, MD 20670 USA. EM john.asvestas@navy.mil; oliver.allen@navy.mil NR 16 TC 7 Z9 8 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-926X J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD FEB PY 2010 VL 58 IS 2 BP 479 EP 487 DI 10.1109/TAP.2009.2037703 PG 9 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 551LL UT WOS:000274210700025 ER PT J AU Broderick, MP Hansen, CJ Irvine, M Metzgar, D Campbell, K Baker, C Russell, KL AF Broderick, M. P. Hansen, C. J. Irvine, M. Metzgar, D. Campbell, K. Baker, C. Russell, K. L. TI Adenovirus 36 seropositivity is strongly associated with race and gender, but not obesity, among US military personnel SO INTERNATIONAL JOURNAL OF OBESITY LA English DT Article DE Ad-36; adenoviruses; viral antibodies; military ID BODY-MASS INDEX; ADIPOSITY; INFECTION; TRANSMISSION; CHICKEN; INSULIN; WEIGHT AB Background: Although several studies have shown a positive association between evidence of anti-adenovirus 36 (Ad-36) antibodies (Ad-36 exposure) and ( 1) obesity and ( 2) serum cholesterol in animals, there is limited research demonstrating this association in humans. There is also limited research on transmission, presentation and demographics of Ad-36 infection. Design: ( 1) Body mass ( body mass index ( BMI)), ( 2) fasting serum cholesterol and triglyceride levels and ( 3) demographic characteristics were compared between Ad-36 seropositive and seronegative groups. The majority of subjects were matched as cases versus controls on a number of demographic variables. Subjects: A total of 150 obese and 150 lean active-duty military personnel were studied. Measurements: Subjects completed a questionnaire regarding demographic and behavioral characteristics. Subject serum samples were tested by serum neutralization assay for the presence of anti-Ad-36 antibodies. Results: In all, 34% of obese and 39% of lean subjects had Ad-36 exposure, an insignificant difference. Serum cholesterol and triglyceride levels were significantly higher among the obese subjects than among the lean, but there were no associations between serum cholesterol and triglyceride levels and Ad-36 exposure. Positive associations were found between Ad-36 exposure and age, race and gender. Conclusion: The study stands in contrast to previous work that has shown a positive relationship between Ad-36 exposure and ( 1) obesity, and ( 2) levels of serum cholesterol and triglycerides. In this study there was no association in either case. Unanticipated relationships between Ad-36 exposure and age, race and gender were found, and this is the first time that such a link between Ad-36 exposure and demographics has been found. International Journal of Obesity ( 2010) 34, 302-308; doi: 10.1038/ijo.2009.224; published online 10 November 2009 C1 [Broderick, M. P.; Hansen, C. J.; Irvine, M.; Metzgar, D.; Campbell, K.; Baker, C.; Russell, K. L.] USN, Hlth Res Ctr, Dept Resp Dis Res, San Diego, CA 92186 USA. RP Broderick, MP (reprint author), USN, Hlth Res Ctr, Dept Resp Dis Res, POB 85122, San Diego, CA 92186 USA. EM michael.broderick@med.navy.mil FU Department of the Navy; Department of Defense or the US Government; US Department of Defense [60501]; Global Emerging Infections Surveillance and Response System [61102A-M010160501] FX We thank the commands of the USS Nimitz and the Naval Base, San Diego, CA, USA for permission to recruit subjects. We are indebted to Dr Joel Gaydos and Dr MAK Ryan for their incipient and continued support of this study. We also are grateful for the contributions of Dr Peter Kammerer, Meghan Donahue, and Ryan Ortiguerra of the Naval Health Research Center Virology Laboratory. This research has been conducted in compliance with all applicable federal regulations governing the protection of human subjects in research (protocol NHRC.2001.0013). The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Navy, the Department of Defense or the US Government. US Department of Defense and the Global Emerging Infections Surveillance and Response System (award 61102A-M010160501) supported us financially. This study represents report 08-XX, supported by the Department of Defense under work unit no. 60501. NR 30 TC 39 Z9 39 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0307-0565 J9 INT J OBESITY JI Int. J. Obes. PD FEB PY 2010 VL 34 IS 2 BP 302 EP 308 DI 10.1038/ijo.2009.224 PG 7 WC Endocrinology & Metabolism; Nutrition & Dietetics SC Endocrinology & Metabolism; Nutrition & Dietetics GA 555JZ UT WOS:000274508100011 PM 19901952 ER PT J AU Booth-Kewley, S Highfill-McRoy, RM Larson, GE Garland, CF AF Booth-Kewley, Stephanie Highfill-McRoy, Robyn M. Larson, Gerald E. Garland, Cedric F. TI Psychosocial Predictors of Military Misconduct SO JOURNAL OF NERVOUS AND MENTAL DISEASE LA English DT Article DE Antisocial behavior; psychiatric disorders; military populations; misconduct; Iraq/Afghanistan wars; veterans; combat ID POSTTRAUMATIC-STRESS-DISORDER; ADVERSE CHILDHOOD EXPERIENCES; MENTAL-HEALTH PROBLEMS; COMBAT EXPOSURE; INTERNALIZING SUBTYPES; EARLY ADOLESCENCE; VIETNAM VETERANS; US MILITARY; GULF-WAR; DELINQUENCY AB The objective of this longitudinal study was to determine psychosocial predictors of military misconduct in a cohort of Marine Corps war veterans. The study included data from 20,746 male Marines who completed a life history questionnaire during initial basic training and were subsequently deployed to a combat zone. Associations between psychosocial variables, psychiatric diagnoses, and subsequent misconduct outcomes were analyzed using Cox proportional hazards regression. The strongest predictors of misconduct outcomes (bad conduct discharges and military demotions) were psychiatric diagnoses and young age at first combat deployment. The results indicate that combat-related psychological disorders may manifest in numerous harmful ways, including impulsive, disruptive, and antisocial behavior. We recommend that the association between misconduct and psychiatric disorders be more explicitly acknowledged in research and treatment efforts involving military war veterans and other trauma victims. C1 [Booth-Kewley, Stephanie; Highfill-McRoy, Robyn M.; Larson, Gerald E.] USN, Hlth Res Ctr, Dept Behav Sci & Epidemiol, San Diego, CA 92106 USA. [Garland, Cedric F.] Univ Calif San Diego, Dept Family & Prevent Med, Moores UCSD Canc Ctr, San Diego, CA 92103 USA. RP Booth-Kewley, S (reprint author), USN, Hlth Res Ctr, Dept Behav Sci & Epidemiol, 140 Sylvester Rd, San Diego, CA 92106 USA. EM stephanie.kewley@med.navy.mil FU US Army Medical Research and Material Command [60817] FX Supported by US Army Medical Research and Material Command under Work Unit 60817. NR 40 TC 13 Z9 13 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-3018 J9 J NERV MENT DIS JI J. Nerv. Ment. Dis. PD FEB PY 2010 VL 198 IS 2 BP 91 EP 98 DI 10.1097/NMD.0b013e3181cc45e9 PG 8 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 558LG UT WOS:000274743200002 PM 20145482 ER PT J AU Booth-Kewley, S Larson, GE Highfill-McRoy, RM Garland, CF Gaskin, TA AF Booth-Kewley, Stephanie Larson, Gerald E. Highfill-McRoy, Robyn M. Garland, Cedric F. Gaskin, Thomas A. TI Correlates of Posttraumatic Stress Disorder Symptoms in Marines Back From War SO JOURNAL OF TRAUMATIC STRESS LA English DT Article ID MENTAL-HEALTH PROBLEMS; US MILITARY PERSONNEL; PERSIAN-GULF-WAR; PSYCHOMETRIC PROPERTIES; PTSD CHECKLIST; DEPLOYMENT STRESSORS; VIETNAM VETERANS; ZONE STRESSORS; RISK-FACTORS; FOLLOW-UP AB The effect of combat and operational stress on the mental health of military personnel is a major concern. The objective of this study was to identify factors associated with possible posttraumatic stress disorder (PTSD). A questionnaire was completed by 1,569 Marines who deployed in support of conflicts in Iraq and Afghanistan (2002-2007). Using the PTSD Checklist with a cutoff score of 44, 17.1 % of the sainple screened positive for possible PTSD. of 9 demographic and psychosocial factors examined in relation to MD, 4 were significant in a multivariate analysis: deployment-related stressors, combat exposure, marital status, and education. Deployment-related stressors bad a stronger association with PT D than any other variable. This is an important finding because deployment-related stressors are potentially modifiable. C1 [Booth-Kewley, Stephanie] USN, Hlth Res Ctr, Behav Sci & Epidemiol Dept, San Diego, CA 92106 USA. [Larson, Gerald E.] Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA. [Larson, Gerald E.] Univ Calif San Diego, Moores UCSD Canc Ctr, La Jolla, CA 92093 USA. [Gaskin, Thomas A.] US Marine Corps, Headquarters, Combat Operat Stress Control, Quantico, VA USA. RP Booth-Kewley, S (reprint author), USN, Hlth Res Ctr, Behav Sci & Epidemiol Dept, San Diego, CA 92106 USA. EM stephanie.kewley@med.navy.mil NR 33 TC 34 Z9 34 U1 1 U2 4 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0894-9867 J9 J TRAUMA STRESS JI J. Trauma Stress PD FEB PY 2010 VL 23 IS 1 BP 69 EP 77 DI 10.1002/jts.20485 PG 9 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA 571FW UT WOS:000275738100010 PM 20104587 ER PT J AU Washburn, EB Parr, TP Hanson-Parr, DM AF Washburn, Ephraim B. Parr, Timothy P. Hanson-Parr, Donna M. TI Micro Videographic Analysis of the Melt Layer of Self-Deflagrating HMX and RDX SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE HMX; Melt Layer; RDX; Temperature Sensitivity ID COMBUSTION; PHASE AB Micro videographic analysis of the thin molten layer on the surface of HMX (Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine) and RDX (Hexahydro-1,3,5-trinitro-1,3.5-triazine) during self deflagration were performed. This was done to gain a better understanding of the physical structure present in this 100-300 mu m layer and give a visual picture for the development of computational models. During steady-state combustion, RDX had a consistent melt layer with vigorous bubble formation. There was a continuous liquid layer throughout combustion and no foam was formed. The surface of HMX during steady-state combustion at ambient initial temperatures was an uneven layer of foam. Foam appeared to convect across the surface in undulating waves. At elevated initial temperatures, the HMX molten layer was a consistent foam layer in both time and space. Micro videography was also done with a diagnostic laser sheet as illumination to measure the melt layer thickness. The RDX bubbling layer was about 217 +/- 30 mu m thick. The HMX foam thickness varied from almost nothing to 660 mu m, with an average value of about 234 +/- 106 mu m. A one-dimensional multiphase propellant ingredient combustion model was modified to represent the foam structure better. A foam model used to model fire suppression foam was implemented. The void fraction had a consistent trend and the calculated burning rate temperature sensitivity increased to follow the experimental measured values better. C1 [Washburn, Ephraim B.] USN, Air Warfare Ctr, Weap Div, China Lake, CA 93555 USA. [Parr, Timothy P.; Hanson-Parr, Donna M.] Jacobs Technol Corp, Ridgecrest, CA 93555 USA. RP Washburn, EB (reprint author), USN, Air Warfare Ctr, Weap Div, China Lake, CA 93555 USA. EM ephraim.washburn@navy.mil FU Office of Naval Research [N0001404WX20376] FX This work was supported by the Office of Naval Research, contract no. N0001404WX20376. NR 15 TC 3 Z9 4 U1 2 U2 7 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 0721-3115 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD FEB PY 2010 VL 35 IS 1 BP 46 EP 52 DI 10.1002/prep.200800087 PG 7 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA 565AK UT WOS:000275260200007 ER PT J AU Holbrook, TL Galarneau, MR Dye, JL Quinn, K Dougherty, AL AF Holbrook, Troy Lisa Galarneau, Michael R. Dye, Judy L. Quinn, Kimberly Dougherty, Amber L. TI Morphine Use after Combat Injury in Iraq and Post-Traumatic Stress Disorder SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID MENTAL-HEALTH PROBLEMS; MAJOR TRAUMA; RISK-FACTORS; PTSD; AFGHANISTAN; CARE; PHARMACOTHERAPY; INTERVENTION; PREVENTION; SYMPTOMS AB BACKGROUND Post-traumatic stress disorder (PTSD) is a common adverse mental health outcome among seriously injured civilians and military personnel who are survivors of trauma. Pharmacotherapy in the aftermath of serious physical injury or exposure to traumatic events may be effective for the secondary prevention of PTSD. METHODS We identified 696 injured U. S. military personnel without serious traumatic brain injury from the Navy-Marine Corps Combat Trauma Registry Expeditionary Medical Encounter Database. Complete data on medications administered were available for all personnel selected. The diagnosis of PTSD was obtained from the Career History Archival Medical and Personnel System and verified in a review of medical records. RESULTS Among the 696 patients studied, 243 received a diagnosis of PTSD and 453 did not. The use of morphine during early resuscitation and trauma care was significantly associated with a lower risk of PTSD after injury. Among the patients in whom PTSD developed, 61% received morphine; among those in whom PTSD did not develop, 76% received morphine (odds ratio, 0.47; P<0.001). This association remained significant after adjustment for injury severity, age, mechanism of injury, status with respect to amputation, and selected injury-related clinical factors. CONCLUSIONS Our findings suggest that the use of morphine during trauma care may reduce the risk of subsequent development of PTSD after serious injury. C1 [Holbrook, Troy Lisa; Galarneau, Michael R.; Dye, Judy L.; Quinn, Kimberly; Dougherty, Amber L.] Naval Hlth Res Ctr, San Diego, CA 92106 USA. [Holbrook, Troy Lisa] EPI SOAR Consulting, San Diego, CA USA. RP Holbrook, TL (reprint author), Naval Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. EM troy@epi-soar.com FU U.S. Navy Bureau of Medicine and Surgery [60808] FX Supported by U.S. Navy Bureau of Medicine and Surgery under the Wounded, Ill, and Injured-Psychological Health-Traumatic Brain Injury Program (work unit 60808). NR 39 TC 170 Z9 175 U1 4 U2 22 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD JAN 14 PY 2010 VL 362 IS 2 BP 110 EP 117 DI 10.1056/NEJMoa0903326 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 543FU UT WOS:000273558500008 PM 20071700 ER PT J AU Landrum, ML Fieberg, AM Chun, HM Crum-Cianflone, NF Marconi, VC Weintrob, AC Ganesan, A Barthel, RV Wortmann, G Agan, BK AF Landrum, Michael L. Fieberg, Ann M. Chun, Helen M. Crum-Cianflone, Nancy F. Marconi, Vincent C. Weintrob, Amy C. Ganesan, Anuradha Barthel, Robert V. Wortmann, Glenn Agan, Brian K. TI The Effect of Human Immunodeficiency Virus on Hepatitis B Virus Serologic Status in Co-Infected Adults SO PLOS ONE LA English DT Article ID ACTIVE ANTIRETROVIRAL THERAPY; T-CELL RESPONSES; NATURAL-HISTORY; HBV INFECTION; HIV-INFECTION; SEROCONVERSION; RECOMMENDATIONS; COINFECTION; MANAGEMENT; MORTALITY AB Background: Factors associated with serologic hepatitis B virus (HBV) outcomes in HIV-infected individuals remain incompletely understood, yet such knowledge may lead to improvements in the prevention and treatment of chronic HBV infection. Methods and Findings: HBV-HIV co-infected cohort participants were retrospectively analyzed. HBV serologic outcomes were classified as chronic, resolved, and isolated-HBcAb. Chronic HBV (CHBV) was defined as the presence of HBsAg on two or more occasions at least six months apart. Risk factors for HBV serologic outcome were assessed using logistic regression. Of 2037 participants with HBV infection, 281 (14%) had CHBV. Overall the proportions of HBV infections classified as CHBV were 11%, 16%, and 19% for CD4 cell count strata of >= 500, 200-499, and,200, respectively (p<0.0001). Risk of CHBV was increased for those with HBV infection occurring after HIV diagnosis (OR 2.62; 95% CI 1.78-3.85). This included the subset with CD4 count >= 500 cells/mu L where 21% of those with HBV after HIV diagnosis had CHBV compared with 9% for all other cases of HBV infection in this stratum (p = 0.0004). Prior receipt of HAART was associated with improved HBV serologic outcome overall (p = 0.012), and specifically among those with HBV after HIV (p = 0.002). In those with HBV after HIV, HAART was associated with reduced risk of CHBV overall (OR 0.18; 95% CI 0.04-0.79); including reduced risk in the subsets with CD4 >= 350 cells/mu L (p<0.001) and CD4 >= 500 cells/mu L (p = 0.01) where no cases of CHBV were seen in those with a recent history of HAART use. Conclusions: Clinical indicators of immunologic status in HIV-infected individuals, such as CD4 cell count, are associated with HBV serologic outcome. These data suggest that immunologic preservation through the increased use of HAART to improve functional anti-HBV immunity, whether by improved access to care or earlier initiation of therapy, would likely improve HBV infection outcomes in HIV-infected individuals. C1 [Landrum, Michael L.; Fieberg, Ann M.; Weintrob, Amy C.; Ganesan, Anuradha; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Landrum, Michael L.; Crum-Cianflone, Nancy F.; Marconi, Vincent C.] San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX USA. [Fieberg, Ann M.] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Chun, Helen M.] USN, Hlth Res Ctr, Dept Def HIV AIDS Prevent Program, San Diego, CA USA. [Crum-Cianflone, Nancy F.] USN, Med Ctr, Infect Dis Clin, San Diego, CA USA. [Weintrob, Amy C.; Wortmann, Glenn] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Div Infect Dis, Bethesda, MD USA. [Barthel, Robert V.] USN, Med Ctr, Div Infect Dis, Portsmouth, VA USA. RP Landrum, ML (reprint author), Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. EM mlandrum@idcrp.org RI Marconi, Vincent/N-3210-2014; OI Marconi, Vincent/0000-0001-8409-4689; Agan, Brian/0000-0002-5114-1669 FU IDCRP [G187YS-RV198]; National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) [Y1-AI-5072] FX Support for this work (IDCRP# G187YS-RV198) was provided by the Infectious Disease Clinical Research Program (IDCRP, www. idcrp. org), a Department of Defense (DoD) program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072. The IDCRP reviewed the study design, collected the data, and provided salary support to investigators (M. L. L. A. M. F., N. F. C., A. C. W., A. G., and B. K. A.). The analyses, conclusions and decision to submit the manuscript are the independent work and decision of the authors. The NIH had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 33 TC 13 Z9 13 U1 0 U2 0 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JAN 13 PY 2010 VL 5 IS 1 AR e8687 DI 10.1371/journal.pone.0008687 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 543EV UT WOS:000273554600036 PM 20084275 ER PT J AU Du, EY Ives, R van Nevel, A She, JH AF Du, Eliza Yingzi Ives, Robert van Nevel, Alan She, Jin-Hua TI Advanced Image Processing for Defense and Security Applications SO EURASIP JOURNAL ON ADVANCES IN SIGNAL PROCESSING LA English DT Editorial Material C1 [Du, Eliza Yingzi] Indiana Univ Purdue Univ Indianapolis, Dept Elect & Comp Engn, Indainapolis, IN 46259 USA. [Ives, Robert] USN Acad, Dept Elect Engn, Annapolis, MD 21402 USA. [van Nevel, Alan] USN, Air Warfare Ctr, Image & Signal Proc Branch, Res Dept, China Lake, CA 93555 USA. [She, Jin-Hua] Tokyo Univ Technol, Sch Comp Sci, Tokyo 1920982, Japan. RP Du, EY (reprint author), Indiana Univ Purdue Univ Indianapolis, Dept Elect & Comp Engn, 723W Michigan St,SL 160, Indainapolis, IN 46259 USA. EM yidu@iupui.edu NR 0 TC 0 Z9 0 U1 1 U2 4 PU HINDAWI PUBLISHING CORPORATION PI NEW YORK PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA SN 1687-6172 J9 EURASIP J ADV SIG PR JI EURASIP J. Adv. Signal Process. PY 2010 AR 432972 DI 10.1155/2010/432972 PG 1 WC Engineering, Electrical & Electronic SC Engineering GA 760MJ UT WOS:000290328100001 ER PT S AU Aebersold, J Walsh, K Beggans, M AF Aebersold J, Julia Walsh, Kevin Beggans, Michael GP IEEE TI Utilization of Direct Write Lithography to Develop Ultra High Aspect Ratio (> 100:1) DRIE Silicon Pillars SO 2010 18TH BIENNIAL UNIVERSITY/GOVERNMENT/INDUSTRY MICRO-NANO SYMPOSIUM SE University Government Industry Micro-Nano Symposium Proceedings LA English DT Proceedings Paper CT 18th Biennial University/Government/Industry Micro-Nano Symposium CY JUN 28-JUL 01, 2010 CL Purdue Univ, West Lafayette, IN SP IEEE HO Purdue Univ AB Aspect ratios for deep reactive ion etching (DRIE) typically do not exceed 100. The discussed technique uses direct write lithography utilizing a Heidelberg DWL 66FS laser pattern generator followed by DRIE and hydrofluoric acid etching to create a nano pillar array on a silicon wafer. Prior to the direct write process, chrome was patterned on the wafer to act as an etch stop once the positive photoresist was consumed via DRIE. The sample was then oxygen-plasma etched to remove any remaining C4F8 residuals, as confirmed by Energy Dispersive X-ray spectroscopy. Remaining oxides were removed with dilute hydrofluoric acid and the wafer was rinsed with de-ionized water. The resulting structure was a nano pillar array with aspect ratios of 129.9:1, where pillar lengths were 50 mu m with widths of 380 nm. C1 [Aebersold J, Julia; Walsh, Kevin] Univ Louisville, Louisville, KY 40292 USA. [Beggans, Michael] Naval Surface Warfare Ctr, Indian Head Div, Indian Head, MARYLAND. RP Aebersold, J (reprint author), Univ Louisville, Louisville, KY 40292 USA. FU U.S. Navy [DAAB07-03-D-B010/TO-0198] FX We gratefully acknowledge the funding for this effort from U.S. Navy Contract DAAB07-03-D-B010/TO-0198. NR 5 TC 0 Z9 0 U1 2 U2 5 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0749-6877 BN 978-1-4244-4732-9 J9 U GOV IND MICRO NANO PY 2010 PG 5 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology SC Engineering; Science & Technology - Other Topics GA BTO08 UT WOS:000287454500032 ER PT S AU Sparr, C Dusch, K AF Sparr, Christopher Dusch, Kevin GP IEEE TI Prioritizing parallel analog re-host Candidates through ATLAS Source Code Analysis SO 2010 IEEE AUTOTESTCON SE IEEE Autotestcon LA English DT Proceedings Paper CT AUTOTESTCON 2010 Systems Readiness Technology Conference CY SEP 13-16, 2010 CL Orlando, FL DE automatic test system source data repository; parallel test capability AB The US Navy's Consolidated Automated Support System (CASS) family of testers is outfitted with three Ai-710 analog test instruments and provides 96 channels of analog test capability, enabling transition from a traditional serial to a parallel test approach. Most CASS test program sets do not take advantage of parallel test capability, which results in long run-times. In this paper, the authors will outline a set of design rules for mining data in the NAVAIR automatic test system source data repository to identify economical targets of opportunity, the development of an initial set of tools to apply the parallel test capability, and show a return on investment for reducing the cost of testing avionics systems. C1 [Sparr, Christopher] Naval Air Syst Command, Mcas Cherry Point, NC 28532 USA. [Dusch, Kevin] Naval Air Syst Command, NAS Patuxent River, MD USA. RP Sparr, C (reprint author), Naval Air Syst Command, Mcas Cherry Point, NC 28532 USA. EM christopher.sparr@navy.mil; kevin.dusch@navy.mil NR 5 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1088-7725 BN 978-1-4244-7959-7 J9 IEEE AUTOTESTCON PY 2010 BP 11 EP 16 PG 6 WC Engineering, Electrical & Electronic SC Engineering GA BTI75 UT WOS:000287044100003 ER PT S AU Cooper, JN Augustine, RA AF Cooper, John N. Augustine, Robert A. GP IEEE TI CASS Phase II TPS Offload Testing, Production and Delivery to the Fleet SO 2010 IEEE AUTOTESTCON SE IEEE Autotestcon LA English DT Proceedings Paper CT AUTOTESTCON 2010 Systems Readiness Technology Conference CY SEP 13-16, 2010 CL Orlando, FL DE CASS; TPS; Offload; Autamated Test; ATE; Lessons learned; NAVAIR AB This paper examines the testing and production processes used on the CASS Phase II TPS Offload Program. The CASS Phase II TPS Offload program is a US Navy acquisition to replace legacy ATE Systems using CASS (Consolidated Automated Support System) Test Stations. This provides the Navy intermediate maintenance activities an effective tool for restoring "Ready For Issue" (RFI) status for over 450 aircraft avionic assemblies. With the completion of these OTPSs the Navy will replace a multitude of obsolete aircraft support testers with one type of station. The Offload team developed over 400 test programs running on 75 unique hardware test sets and produced a total of 1143 Operational Test Program Sets along with accompanying spares for the US Navy. From integration to deployment to the Fleet, a variety of test processes are encountered and with the numerous test programs being developed, the team found itself in some form of "final" test for most of the program life cycle. The TPS Offload team brought together the developers, buyers and the end users to streamline these processes without reducing the quality of the product. We will examine the evolution of the acceptance test approach for the CASS Phase II TPS Offload Program, the costs and benefits of the various testing phases and the lessons learned as we combined many aspects of testing along the way. The paper will further discuss the transition from development to production. The first production units were delivered in August 2005 and by the end of 2010 we will have delivered 1143 test sets to sites around the world. To prepare for this complex production effort, a multi-disciplined team was established to conduct Pre-production kaizens at the Orlando and La Mesa facilities. The team included our US Navy and DCMA customers. A single piece flow operation was developed which allowed for early production delivery of multiple configurations to the US Navy. Subassemblies, such as cables and test fixtures would be built at a low cost manufacturing facility in La Mesa, Mexico, while final assembly and acceptance test would take place at the Lockheed Martin Simulation, Training & Support facility in Orlando. The operating plan, layout and support model for the production operation evolved and lessons learned were incorporated in each successive block of production. C1 [Cooper, John N.] Lockheed Martin Global Training & Logist, Orlando, FL 32801 USA. [Augustine, Robert A.] Naval Air Syst Command, Patuxent River, MA USA. RP Cooper, JN (reprint author), Lockheed Martin Global Training & Logist, Orlando, FL 32801 USA. EM john.n.cooper@lmco.com; robert.a.augustine@navy.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1088-7725 BN 978-1-4244-7959-7 J9 IEEE AUTOTESTCON PY 2010 BP 201 EP 205 PG 5 WC Engineering, Electrical & Electronic SC Engineering GA BTI75 UT WOS:000287044100039 ER PT S AU Son, S de Nolfo, GA Dion, MP Hunter, SD Guardala, NA AF Son, Seunghee de Nolfo, Georgia A. Dion, M. P. Hunter, Stanley D. Guardala, Noel A. GP IEEE TI Neutron Imaging Camera SO 2010 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD (NSS/MIC) SE IEEE Nuclear Science Symposium Conference Record LA English DT Proceedings Paper CT IEEE Nuclear Science Symposium (NSS)/Medical Imaging Conference (MIC)/17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors CY OCT 30-NOV 06, 2010 CL Knoxville, TN SP Inst Elect & Elect Engineers, Nucl & Plasma Sci Soc, IEEE ID DIFFUSION AB We describe the Neutron Imaging Camera (NIC) being developed for the detection of special nuclear material by NASA/Goddard Space Flight Center (GSFC) and NSWC/Carderock. The NIC is a self-contained, robust, omnidirectional, and 3 He-independent neutron detector based on the Three-Dimensional Track Imager (3-DTI) technology developed at GSFC for gamma-ray astrophysics applications. The 3-DTI, a large volume, gas, time-projection chamber, provides accurate, similar to 0.4 mm resolution, 3-D tracking of charged particles. The incident direction of fast neutrons, 0.1 MeV < E-n < 10 MeV, are reconstructed from the momenta and energies of the protons resulting from single and double (n, p) scatters in methane (CH4). We present angular and energy resolution performance of the NIC derived from the field test at Ft. Monroe, VA in September 2010. C1 [Son, Seunghee; de Nolfo, Georgia A.; Hunter, Stanley D.] NASA, CRESST UMBC, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. [Dion, M. P.; Guardala, Noel A.] Carderock Divi, Naval Surface Warfare Ctr, Bethesda, MD 20817 USA. RP Son, S (reprint author), NASA, CRESST UMBC, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. EM seunghee.son@nasa.gov RI de Nolfo, Georgia/E-1500-2012; OI Dion, Michael/0000-0002-3030-0050 FU Office of Naval Research M-WMD-D program FX This work was supported in part by the Office of Naval Research M-WMD-D program. NR 7 TC 1 Z9 1 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1082-3654 BN 978-1-4244-9106-3 J9 IEEE NUCL SCI CONF R PY 2010 BP 298 EP 301 PG 4 WC Engineering, Electrical & Electronic; Nuclear Science & Technology; Physics, Applied SC Engineering; Nuclear Science & Technology; Physics GA BBB94 UT WOS:000306402900063 ER PT S AU Garzarella, A Wu, DH Crim, JB AF Garzarella, Anthony Wu, Dong Ho Crim, John B. GP IEEE TI An All-Dielectric, 3-Axis Electric Field Sensor Using Quasi-Longitudinally Configured Electro-Optic Crystals SO 2010 IEEE SENSORS SE IEEE Sensors LA English DT Proceedings Paper CT 2010 IEEE Sensors Conference CY NOV 01-04, 2010 CL Kona, HI SP IEEE AB We describe a stabilized, all-dielectric, 3-axis electric field sensor using electro-optic (EO) crystals. By directing the laser probe quasi-longitudinally with respect to the optic axis of the crystal, we have improved stability by three orders of magnitude and substantially reduced phase noise. While the modulation depth of the output signal is slightly reduced, overall sensitivity is greatly improved due to the larger signal to noise ratio. Unlike conventional EO sensors, measurements can be made with 50 meters of optical fibers without excessive noise. Additionally, the sensor and fibers can be moved during measurements without the need for compensation optics or recalibration. This makes the sensor very practical for actual field test applications and attractive for potential commercial use. C1 [Garzarella, Anthony; Wu, Dong Ho] USN, Res Lab, Washington, DC 20375 USA. [Crim, John B.] Naval Air Warfare Ctr, Naval Electmagnet Radiat Facil, Patuxent River, MD USA. RP Garzarella, A (reprint author), USN, Res Lab, Washington, DC 20375 USA. EM tony.garzarella@nrl.navy.mil FU T&E/S&T Program through U.S. Army Program Executive Office for Simulation, Training and Instrumentation FX This work is funded by the T&E/S&T Program through the U.S. Army Program Executive Office for Simulation, Training and Instrumentation. NR 5 TC 2 Z9 2 U1 2 U2 4 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1930-0395 BN 978-1-4244-8168-2 J9 IEEE SENSOR PY 2010 BP 983 EP 986 DI 10.1109/ICSENS.2010.5690916 PG 4 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA BTS59 UT WOS:000287982100218 ER PT J AU Wells, TS LeardMann, CA Fortuna, SO Smith, B Smith, TC Ryan, MAK Boyko, EJ Blazer, D AF Wells, Timothy S. LeardMann, Cynthia A. Fortuna, Sarah O. Smith, Besa Smith, Tyler C. Ryan, Margaret A. K. Boyko, Edward J. Blazer, Dan CA Millennium Cohort Study Team TI A Prospective Study of Depression Following Combat Deployment in Support of the Wars in Iraq and Afghanistan SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; PERSIAN-GULF-WAR; MILLENNIUM COHORT; MILITARY SERVICE; PRIMARY-CARE; US MILITARY; MAJOR DEPRESSION; UNITED-STATES; PEACEKEEPING OPERATIONS AB Objective. We investigated relations between deployment and new-onset depression among US service members recently deployed to the wars in Iraq and Afghanistan. Methods. We included 40219 Millennium Cohort Study participants who completed baseline and follow-up questionnaires and met inclusion criteria. Participants were identified with depression if they met the Primary Care Evaluation of Mental Disorders Patient Health Questionnaire criteria for depression at follow-up, but not at baseline. Results. Deployed men and women with combat exposures had the highest onset of depression, followed by those not deployed and those deployed without combat exposures. Combat-deployed men and women were at increased risk for new-onset depression compared with nondeployed men and women (men: adjusted odds ratio [AOR]=1.32; 95% confidence interval [CI]=1.13, 1.54; women: AOR=2.13; 95% CI=1.70, 2.65). Conversely, deployment without combat exposures led to decreased risk for new-onset depression compared with those who did not deploy (men: AOR=0.66; 95% CI=0.53, 0.83; women: AOR = 0.65; 95% CI = 0.47, 0.89). Conclusions. Deployment with combat exposures is a risk factor for new-onset depression among US service members. Post-deployment screening may be beneficial for US service members exposed to combat. (Am J Public Health. 2010;100:90-99. doi:10.2105/AJPH.2008.155432) C1 [Wells, Timothy S.; Fortuna, Sarah O.] USAF, Res Lab, Wright Patterson AFB, OH 45433 USA. [LeardMann, Cynthia A.; Smith, Besa; Smith, Tyler C.; Ryan, Margaret A. K.] USN, US Dept Def, Ctr Deployment Hlth Res, Hlth Res Ctr, San Diego, CA 92152 USA. [Boyko, Edward J.] VA Puget Sound Hlth Care Syst, Seattle Epidemiol Res & Informat Ctr, Seattle, WA USA. [Blazer, Dan] Duke Univ, Med Ctr, Durham, NC USA. RP Wells, TS (reprint author), 711th HPW RHPA,Bldg 824,Room 206,2800 Q St, Wright Patterson AFB, OH 45433 USA. EM timothy.wells@wpafb.af.mil RI Blazer II, Dan/D-6675-2012 FU Department of Defense [60002] FX This work represents report 08-06, supported by the Department of Defense, under work unit no. 60002.The views expressed in this article are those of the authors and do not reflect the official policy or position ofthe Department of the Navy, Department of the Army, Department of the Air- Force, Department of Defense, Department of Veterans Affairs, or the US Govemment. NR 82 TC 106 Z9 106 U1 10 U2 17 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JAN PY 2010 VL 100 IS 1 BP 90 EP 99 DI 10.2105/AJPH.2008.155432 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 538EK UT WOS:000273166800020 PM 19910353 ER PT J AU Harvey, BG Wright, ME Quintana, RL AF Harvey, Benjamin G. Wright, Michael E. Quintana, Roxanne L. TI High-Density Renewable Fuels Based on the Selective Dimerization of Pinenes SO ENERGY & FUELS LA English DT Article ID CATALYTIC CONVERSION; SILICA NANOCOMPOSITE; ACID CATALYSTS; ALKYLATION; COMPOSITE; LIMONENE AB High-density fuel candidates have been synthesized in up to 90% yield from beta-pinene, a renewable strained bicyclic compound derived from wood and plant Sources. The process is based oil the heterogeneous acidic catalysts Montmorillonite-K10 and Nafion, which promote selective isomerization and dimerization of pinenes under moderate conditions (100 degrees C and atmospheric pressure). Montmorillonite-K10 was shown to be a highly active catalyst for dimerization but was also active in the ring opening of beta-pinene followed by dehydrogenation to produce p-cymene, which limited the yield of the dimer to ca. 75%. Nafion was capable of producing dimers in up to 90% yield primarily through isomerization followed by dimerization. Amberlyst-15 a common industrial catalyst had very poor activity and conversion even at 150 degrees C. The dimer mixtures were upgraded through hydrogenation over PtO(2) and fractional distillation. The synthesized fuels have a density of 0.94 g/cm(3) and a net volumetric heating value of 39.5 MJ/L (141 745 BTU/gallon). These values are nearly identical to those for the widely used tactical fuel JP-10 (primarily composed of exotetrahydrodicyclopentadiene), suggesting that these renewable fuels may have applications for rocket propulsion. C1 [Harvey, Benjamin G.; Wright, Michael E.; Quintana, Roxanne L.] USN, Naval Air Syst Command, Naval Air Warfare Ctr, Weap Div,Res Dept,Chem Div, China Lake, CA 93555 USA. RP Harvey, BG (reprint author), USN, Naval Air Syst Command, Naval Air Warfare Ctr, Weap Div,Res Dept,Chem Div, China Lake, CA 93555 USA. EM benjamin.g.harvey@navy.mil FU NAWCWD; Office of Naval Research FX The authors thank Andrew Chafin for gas-phase heat of formation calculations and NAWCWD and the Office of Naval Research (In-House Laboratory Independent Research Program) for funding this work. NR 34 TC 83 Z9 86 U1 4 U2 67 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0887-0624 J9 ENERG FUEL JI Energy Fuels PD JAN PY 2010 VL 24 BP 267 EP 273 DI 10.1021/ef900799c PG 7 WC Energy & Fuels; Engineering, Chemical SC Energy & Fuels; Engineering GA 555MI UT WOS:000274514500038 ER PT J AU Dharmasena, KP Queheillalt, DT Wadley, HNG Dudt, P Chen, Y Knight, D Evans, AG Deshpande, VS AF Dharmasena, K. P. Queheillalt, D. T. Wadley, H. N. G. Dudt, P. Chen, Y. Knight, D. Evans, A. G. Deshpande, V. S. TI Dynamic compression of metallic sandwich structures during planar impulsive loading in water SO EUROPEAN JOURNAL OF MECHANICS A-SOLIDS LA English DT Article DE Sandwich panels; Underwater impulsive loading; Fluid/structure interaction; Metal foams, lattices and honeycombs ID PANELS; BEAMS; BLAST; RESISTANCE; BEHAVIOR; PLATES AB The compressive response of rigidly supported stainless steel sandwich panels subject to a planar impulsive load in water is investigated. Five core topologies that spanned a wide range of crush strengths and strain-dependencies were investigated. They included a (i) square-honeycomb, (ii) triangular honeycomb, (iii) multi-layer pyramidal truss, (iv) triangular corrugation and (v) diamond corrugation, all with a core relative density of approximately 5%. Quasi-statically, the honeycombs had the highest peak strength, but exhibited strong softening beyond the peak strength. The truss and corrugated cores had significantly lower strength, but a post yield plateau that extended to beyond a plastic strain of 60% similar to metal foams. Dynamically, the transmitted pressures scale with the quasi-static strength. The final transmitted momentum increased slowly with core strength (provided the cores were not fully crushed). It is shown that the essential aspects of the dynamic response, such as the transmitted momentum and the degree of core compression, are captured with surprising fidelity by modeling the cores as equivalent metal foams having plateau strengths represented by the quasi-static peak strength. The implication is that, despite considerable differences in core topology and dynamic deformation modes, a simple foam-like model replicates the dynamic response of rigidly supported sandwich panels subject to planar impulsive loads. It remains to ascertain whether such foam-like models capture more nuanced aspects of sandwich panel behavior when locally loaded in edge clamped configurations. (C) 2009 Elsevier Masson SAS. All rights reserved. C1 [Dharmasena, K. P.; Queheillalt, D. T.; Wadley, H. N. G.] Univ Virginia, Dept Mat Sci & Engn, Charlottesville, VA 22904 USA. [Dudt, P.; Chen, Y.; Knight, D.] Naval Surface Warfare Ctr, Carderock, MD 20817 USA. [Evans, A. G.] Univ Calif Santa Barbara, Dept Mech Engn, Santa Barbara, CA 93106 USA. [Deshpande, V. S.] Univ Cambridge, Dept Engn, Cambridge CB2 1PZ, England. RP Dharmasena, KP (reprint author), Univ Virginia, Dept Mat Sci & Engn, 395 McCormick Rd, Charlottesville, VA 22904 USA. EM kumar@virginia.edu RI Deshpande, Vikram/C-6750-2013 OI Deshpande, Vikram/0000-0003-3899-3573 FU Office of Naval Research [N00014-03-1-0281] FX This research was supported by the Office of Naval Research grant number N00014-03-1-0281 on Blast and Fragmentation Protection Sandwich Panel Concepts for Stainless Steel Monohull designs monitored by Drs. Edward Johnson and Daniel Tam. NR 21 TC 30 Z9 35 U1 4 U2 41 PU GAUTHIER-VILLARS/EDITIONS ELSEVIER PI PARIS PA 23 RUE LINOIS, 75015 PARIS, FRANCE SN 0997-7538 J9 EUR J MECH A-SOLID JI Eur. J. Mech. A-Solids PD JAN-FEB PY 2010 VL 29 IS 1 BP 56 EP 67 DI 10.1016/j.euromechsol.2009.05.003 PG 12 WC Mechanics SC Mechanics GA 510OU UT WOS:000271100200007 ER PT S AU Kurti, RS Halterman, K Shori, RK Arian, C Wardlaw, MJ AF Kurti, R. Steven Halterman, Klaus Shori, Ramesh K. Arian, Cyrus Wardlaw, Michael J. BE Tankala, K Dawson, JW TI Creating discrete cylindrical vector beams using coherently combined fiber arrays SO FIBER LASERS VII: TECHNOLOGY, SYSTEMS, AND APPLICATIONS SE Proceedings of SPIE LA English DT Proceedings Paper CT 7th Conference on Fiber Lasers - Technology, Systems, and Applications CY JAN 25-28, 2010 CL San Francisco, CA SP SPIE, Fianium Ltd, PolarOnyx Inc DE Cylindrical vector beam; coherent beam combining; radial vector beam; fiber array; cylindrical symmetry; radial polarization; azimuthal polarization ID RADIALLY POLARIZED BEAMS; LASER-BEAM; GENERATION; BIREFRINGENCE; COMBINATION; AZIMUTHAL; DEVICE; PRISM; MODE AB A novel method is presented for beam shaping far field intensity distributions using coherently combined fiber arrays. Traditionally, coherent arrays have been composed of linearly polarized elements having their polarization vector along a common axis. In this novel method, the fibers are arranged uniformly on the perimeter of a circle, and the linearly polarized beams are oriented with their polarization vectors arranged in a cylindrical fashion such that each subsequent vector is rotated by 2 pi/N where N is the number of elements on the circle. The elements each have the same Gaussian intensity distribution and power. The ensemble yields a far field intensity pattern that is a good approximation to a cylindrical vector (CV) beam which is characterized by a nonuniform polarization distribution and a null in the center of the beam. These synthetically created CV beams, or discrete cylindrical vector (DCV) beams, can be represented in a closed form solution to predict the far field intensity distributions. This solution is shown to agree with experimental results where several values of N, the number of elements, were tested. In addition, some more complex geometries such as nested geometries, fractal geometries, and some nonuniform geometries have been simulated, all of which also have a central null in the beam and have a nonuniform polarization distribution. These results are in contrast to linearly polarized beams, where the intensity peaks on axis, and from traditional cylindrical vector beams, which are generated by a single laser cavity. C1 [Kurti, R. Steven] Loma Linda Univ, Sch Dent, Loma Linda, CA 92350 USA. RP Halterman, K (reprint author), USN, Res & Intelligence Dept, Div Phys, Air Warfare Ctr, China Lake, CA 93555 USA. EM klaus.halterman@navy.mil RI Halterman, Klaus/G-3826-2012 NR 31 TC 0 Z9 0 U1 0 U2 3 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7976-1 J9 PROC SPIE PY 2010 VL 7580 AR 75801P DI 10.1117/12.841588 PG 8 WC Optics; Physics, Applied SC Optics; Physics GA BRS51 UT WOS:000283536200054 ER PT J AU Groshens, TJ AF Groshens, Thomas J. TI Synthesis, characterization, and coordination chemistry of the dihydrobis(5-aminotetrazol-1-yl)borate anion SO JOURNAL OF COORDINATION CHEMISTRY LA English DT Article DE Coordination polymers; Bridging ligands; Tetrazolylborate; 5-Aminotetrazole; Boronium ion ID TRANSITION-METAL COMPLEXES; WATER SUBSTRUCTURES; LIGAND; POLYMERS AB The new anionic dihydrobis(5-aminotetrazol-1-yl)borate ligand was synthesized in high yield and structurally characterized. Electron donating effects of the amino substituent on the tetrazole ring are discussed comparing the basicity and coordination chemistry to the previously reported unsubstituted dihydrobistetrazol-1-ylborate anion. Both mono- and diprotonated ligand species were isolated and structurally characterized. Increased sigma-electron donating strength of the aminotetrazole compound provides more than one tetrazolyl nitrogen position capable of metal coordination. One-dimensional coordination polymers of {H2B(H2NCN4)2}2Cu(NH3)2 and {H2B(H2NCN4)2}Zn(NH3)Cl are structurally characterized demonstrating both a symmetrically bridging and a new unsymmetrically bridging motif involving more than one of the tetrazolyl ring positions of the ligand. C1 USN, Air Warfare Ctr, Weap Div, China Lake, CA 93555 USA. RP Groshens, TJ (reprint author), USN, Air Warfare Ctr, Weap Div, China Lake, CA 93555 USA. EM thomas.groshens@navy.mil NR 18 TC 8 Z9 8 U1 0 U2 2 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0095-8972 J9 J COORD CHEM JI J. Coord. Chem. PY 2010 VL 63 IS 11 BP 1882 EP 1892 AR PII 923377538 DI 10.1080/00958972.2010.495775 PG 11 WC Chemistry, Inorganic & Nuclear SC Chemistry GA 622ZP UT WOS:000279706500006 ER PT J AU MacGregor, AJ Shaffer, RA Dougherty, AL Galarneau, MR Raman, R Baker, DG Lindsay, SR Golomb, BA Corson, KS AF MacGregor, Andrew J. Shaffer, Richard A. Dougherty, Amber L. Galarneau, Michael R. Raman, Rema Baker, Dewleen G. Lindsay, Suzanne R. Golomb, Beatrice A. Corson, Karen S. TI Prevalence and Psychological Correlates of Traumatic Brain Injury in Operation Iraqi Freedom SO JOURNAL OF HEAD TRAUMA REHABILITATION LA English DT Article DE military; posttraumatic stress disorder; PTSD; traumatic brain injury ID POSTTRAUMATIC-STRESS-DISORDER; MOTOR-VEHICLE ACCIDENTS; ROAD TRAFFIC ACCIDENTS; PSYCHIATRIC-DISORDERS; HEAD-INJURY; COMBAT VETERANS; SEVERITY SCORE; EVENT; REGISTRY; AMNESIA AB Objective: To describe the prevalence and psychological correlates of traumatic brain injury (TBI) among injured male combatants in the Iraq conflict. Participants: A total of 781 men injured during military combat between September 2004 and February 2005. Main Outcome Measures: Mental health diagnosis (ICD-9 290-319), particularly posttraumatic stress disorder and mood/anxiety disorders, assigned through November 2006. Results: 15.8% met criteria for TBI (13.4% mild, 2.4% moderate-severe TBI), 35.0% other head injury, and 49.2% non-head injury. Multivariate logistic regression suggested lower rates of posttraumatic stress disorder and mood/anxiety disorders among those with mild and moderate-severe TBI. Conclusions: These findings could reflect a problem with differential diagnosis or, conversely, a low rate of self-presentation for symptoms. Further research is needed to elucidate the psychological consequences, clinical implications, and overall impact of TBI among military combat veterans. C1 [MacGregor, Andrew J.; Shaffer, Richard A.; Galarneau, Michael R.; Corson, Karen S.] USN, Hlth Res Ctr, San Diego, CA 92106 USA. [Dougherty, Amber L.] Sci Applications Int Corp, San Diego, CA USA. [Raman, Rema; Baker, Dewleen G.; Golomb, Beatrice A.] Univ Calif San Diego, San Diego, CA 92103 USA. [Baker, Dewleen G.] VA San Diego Healthcare Syst, San Diego, CA USA. [Lindsay, Suzanne R.] San Diego State Univ, San Diego, CA 92182 USA. RP Dougherty, AL (reprint author), USN, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. EM amber.dougherty@med.navy.mil FU US Navy Bureau of Medicine and Surgery, Washington, DC FX This work was supported by the US Navy Bureau of Medicine and Surgery, Washington, DC, under Work Unit No. 60819. The views and opinions expressed herein are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, nor the US Government. This research has been conducted in compliance with all applicable federal regulations governing the protection of human subjects in research (Protocol NHRC.2007.0004). NR 53 TC 47 Z9 47 U1 2 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0885-9701 J9 J HEAD TRAUMA REHAB JI J. Head Trauma Rehabil. PD JAN-FEB PY 2010 VL 25 IS 1 BP 1 EP 8 PG 8 WC Clinical Neurology; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA 550XC UT WOS:000274165800001 PM 20051901 ER PT J AU Ganio, MS Armstrong, LE Johnson, EC Klau, JF Ballard, KD Michniak-Kohn, B Kaushik, D Maresh, CM AF Ganio, Matthew S. Armstrong, Lawrence E. Johnson, Evan C. Klau, Jennifer F. Ballard, Kevin D. Michniak-Kohn, Bozena Kaushik, Diksha Maresh, Carl M. TI Effect of quercetin supplementation on maximal oxygen uptake in men and women SO JOURNAL OF SPORTS SCIENCES LA English DT Article DE Flavonoid; maximal oxygen uptake; endurance; exercise; aerobic capacity ID EXERCISE; INGESTION; PERFORMANCE; ENDURANCE; ILLNESS; HUMANS; MUSCLE AB Quercetin is a naturally occurring flavonoid with anti-oxidant and anti-inflammatory properties. The effect of quercetin supplementation on maximal oxygen uptake ((V) over dotO(2max)) is unknown. The purpose of this investigation was to test the effects of quercetin supplementation on (V) over dotO(2max) in untrained, sedentary individuals. After baseline treadmill (V) over dotO(2max) testing, 11 participants (5 males, 6 females) ingested either placebo or quercetin-supplemented (1000 mg . day(-1)) food bars in a randomized, double-blind, counterbalanced, crossover research design. The participants ingested food bars for six consecutive mornings (5 days). On the sixth morning, participants underwent repeat (V) over dotO(2max) testing. After a 22 day wash-out, the participants repeated baseline (V) over dotO(2max) testing, daily consumption of the opposite food bars, and post-supplementation (V) over dotO(2max) testing. The condition x time interaction for (V) over dotO(2max) was non-significant when expressed in absolute (litres . min(-1); P=0.929) and relative (ml . kg(-1) . min(-1); P=0.778) terms. These findings were similar when taking sex into account (P>0.05). The mean difference in (V) over dotO(2max) change from pre to post between groups (quercetin vs. placebo) was 0.139 ml . kg(-1) . min(-1) (P=0.780). Other physiological measures also were similar between conditions (P>0.05). In conclusion, 5 days of quercetin supplementation did not influence (V) over dotO(2max) or related variables in sedentary men and women. C1 [Ganio, Matthew S.; Armstrong, Lawrence E.; Johnson, Evan C.; Klau, Jennifer F.; Ballard, Kevin D.; Maresh, Carl M.] Univ Connecticut, Human Performance Lab, Storrs, CT USA. [Johnson, Evan C.] USN, Hlth Res Ctr, Warfighter Performance Dept, San Diego, CA 92152 USA. [Michniak-Kohn, Bozena; Kaushik, Diksha] Rutgers State Univ, Dept Pharmaceut, Piscataway, NJ USA. RP Ganio, MS (reprint author), Texas Hlth Presbyterian Hosp Dallas, Inst Exercise & Environm Med, 7232 Greenville Ave, Dallas, TX 75231 USA. EM matthewganio@texashealth.org OI Ballard, Kevin/0000-0001-7587-1220 NR 23 TC 18 Z9 18 U1 0 U2 7 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0264-0414 J9 J SPORT SCI JI J. Sports Sci. PY 2010 VL 28 IS 2 BP 201 EP 208 DI 10.1080/02640410903428558 PG 8 WC Sport Sciences SC Sport Sciences GA 556VF UT WOS:000274620700010 PM 20054739 ER PT J AU Stenger-Smith, JD Guenthner, A Cash, J Irvin, JA Irvin, DJ AF Stenger-Smith, John D. Guenthner, Andrew Cash, Jessica Irvin, Jennifer A. Irvin, David J. TI Poly(propylenedioxy)thiophene-Based Supercapacitors Operating at Low Temperatures SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article DE differential scanning calorimetry; electrolytes; high-temperature effects; liquid mixtures; polymer films; supercapacitors ID IONIC LIQUIDS; BATTERIES; ELECTROLYTES; POLYMERS; DEVICES AB A mixture of the ionic liquids 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide (EMIBTI) and 1-ethyl-3-methylimidazolium hexafluorophosphate (EMIPF6) was formulated. The thermal properties of the 50/50 binary mixture were determined by differential scanning calorimetry and cloud point measurement. No evidence of crystallization or phase separation during cooling at 1 degrees C/min to -60 degrees C was found. The devices constructed in this study were light weight, flexible, and hermetically sealed. These sealed devices proved effective against electrolyte leakage and performance degradation during temperature cycling. The performance of poly(propylenedioxy) thiophene (PProDOT)-based type I supercapacitors using a 50/50 wt % EMIBTI/EMIPF6 electrolyte mixture was compared to the performance using neat EMIBTI. It was difficult to deposit PProDOT films directly from the ionic liquid mixtures. However, it was possible to deposit PProDOT films from EMIBTI and then assemble and test the devices using the 50/50 mixture. The low temperature performance of the EMIBTI/EMIPF6 supercapacitors was superior to that of the EMIBTI-based supercapacitors, evidenced by the retention of capacitive behavior below -30 degrees C. The high temperature performance of the EMIBTI/EMIPF6 supercapacitors was nearly as good as the EMIBTI-based supercapacitors with 10% loss after 10,000 cycles at 70% depth of discharge at 60 degrees C. C1 [Stenger-Smith, John D.; Guenthner, Andrew; Cash, Jessica] USN, Air Warfare Ctr, Weap Div, China Lake, CA 93555 USA. [Irvin, Jennifer A.] SW Texas State Univ, Dept Chem & Biochem, San Marcos, TX 78666 USA. [Irvin, David J.] Syst & Mat Res Corp, Austin, TX 78756 USA. RP Stenger-Smith, JD (reprint author), USN, Air Warfare Ctr, Weap Div, China Lake, CA 93555 USA. EM john.stenger-smith@navy.mil RI Irvin, Jennifer/C-7968-2013 OI Irvin, Jennifer/0000-0003-3500-8419 FU Power Sources Strategic Technology Initiative Office FX The authors thank the Office of Naval Research and, in particular, Dr. M. Anderson, Dr. P. Armistead, and Dr. R. Carlin; the Power Sources Strategic Technology Initiative Office for support, Dr. David Hess for the viscosity measurements, and student Michael Ford for technical assistance. The gift of Kapton HN from E. I. du Pont de Nemours and Company is greatly appreciated. The gift of the ShieldPack PPD material from Greg Less of T/J Technologies is greatly appreciated. The authors thank Dr. Gregory Ostrom and Mark Moran for assistance with electrode substrate preparation, and Dan Kline and Joe Hibbs III for technical assistance with the scanning electron microscopy. The authors also thank the reviewers, especially reviewer 1 for suggestions on our manuscript. NR 25 TC 9 Z9 10 U1 1 U2 12 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 SOUTH MAIN STREET, PENNINGTON, NJ 08534 USA SN 0013-4651 EI 1945-7111 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PY 2010 VL 157 IS 3 BP A298 EP A304 DI 10.1149/1.3276094 PG 7 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA 552VO UT WOS:000274321900010 ER PT J AU Kennell, C AF Kennell, Colen TI On the Nature of the Transport Factor Component TFfuel SO MARINE TECHNOLOGY AND SNAME NEWS LA English DT Article DE high speed craft; design (vessels); design (general); multi-hulls; catamarans; surface effect ships; trimarans AB This paper presents insight into the structure of TFfuel, the Transport Factor component related to the weight of fuel needed to meet a ship's endurance requirement. TFfuel is shown to be dependent on the required range and the specific fuel consumption rate of the machinery while being independent of installed power and speed. The effect of operating ships at less than full-load displacement to increase fuel efficiency is illustrated. The results are compatible with Transport Factor analyses that assess transport properties of ship types of interest for high-speed sealift such as displacement and semi-displacement monohulls and multihulls. C1 Ctr Innovat Ship Design, Naval Surface Warfare Ctr, Carderock Div, Bethesda, MD USA. RP Kennell, C (reprint author), Ctr Innovat Ship Design, Naval Surface Warfare Ctr, Carderock Div, Bethesda, MD USA. FU Mobility Combat Logistics Division [OPNAV N42]; USNavy/PEOShips [PMS 385] FX The continued support provided by the Mobility Combat Logistics Division (OPNAV N42) and USNavy/PEOShips (PMS 385) for high-speed sealift research is gratefully acknowledged. NR 7 TC 0 Z9 0 U1 1 U2 1 PU SOC NAVAL ARCH MARINE ENG PI JERSEY CITY PA 601 PAVONIA AVENUE, JERSEY CITY, NJ 07306 USA SN 0025-3316 J9 MAR TECHNOL SNAME N JI Mar. Technol. Sname News PD JAN PY 2010 VL 47 IS 1 BP 59 EP 64 PG 6 WC Engineering, Ocean; Oceanography SC Engineering; Oceanography GA 553LX UT WOS:000274369400006 ER PT J AU Negus, TL Brown, CJ Konoske, P AF Negus, Tracy L. Brown, Carrie J. Konoske, Paula TI Determining Medical Staffing Requirements for Humanitarian Assistance Missions SO MILITARY MEDICINE LA English DT Article AB Objective: The primary mission of hospital ships is to provide acute medical and surgical services to U.S. forces during military operations. Hospital ships also provide a hospital asset in support of disaster relief and humanitarian assistance (HA) operations. HA missions afford medical care to populations with vastly different sets of medical conditions from combat casualty care, which affects staffing requirements. Methods: Information from a variety of sources was reviewed to better understand hospital ship HA missions. Factors such as time on-site and location shape the mission and underlying goals. Results: Patient encounter data from previous HA missions were used to determine expected patient conditions encountered in various HA operations. These data points were used to project the medical staffing required for future missions. Conclusions: Further data collection, along with goal setting, must be performed to accomplish successful future HA missions. Refining staffing requirements allows deployments to accomplish needed HA and effectively reach underserved areas. C1 [Negus, Tracy L.; Brown, Carrie J.; Konoske, Paula] USN, Hlth Res Ctr, San Diego, CA 92106 USA. RP Negus, TL (reprint author), USN, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. FU Office of Naval Research [60608] FX This work represents report 07-44 and was supported by the Office of Naval Research under work unit no. 60608. NR 9 TC 5 Z9 6 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JAN PY 2010 VL 175 IS 1 BP 1 EP 6 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 582GN UT WOS:000276584800005 PM 20108835 ER PT J AU Momen, N Taylor, MK Pietrobon, R Gandhi, M Markham, AE Padilla, GA Miller, PW Evans, KE Sander, TC AF Momen, Nausheen Taylor, Marcus K. Pietrobon, Ricardo Gandhi, Mihir Markham, Amanda E. Padilla, Genieleah A. Miller, Paul W. Evans, Katherine E. Sander, Todd C. TI Initial Validation of the Military Operational Risk Taking Scale (MORTS) SO MILITARY PSYCHOLOGY LA English DT Article ID SENSATION SEEKING; PROPENSITY; ANXIETY; BEHAVIORS AB Risk is an inherent component of military operations. A 31-item Military Operational Risk Taking Scale (MORTS) was developed to identify military personnel with the tendency to engage in or avoid operationally nonessential risks that are maladaptive to the mission. Three hundred and thirty-three active duty Marine Corps personnel completed the MORTS along with two measures of non-military-specific risk taking: Domain-Specific Risk-Attitude Scale (DOSPERT) and Evaluation of Risk Scale (EVAR). The participants also completed the State-Trait Anxiety Inventory (STAI). The MORTS had excellent internal reliability and convergent validity with risk-taking scales of other domains. The responses to the 31 items of the MORTS were subjected to principal components analysis (PCA) with a Varimax rotation. Preliminary findings demonstrated that the MORTS may identify individuals who are likely to participate in essential/adaptive versus nonessential/maladaptive operational risk. C1 [Momen, Nausheen; Markham, Amanda E.; Padilla, Genieleah A.; Miller, Paul W.; Evans, Katherine E.; Sander, Todd C.] USN, Hlth Res Ctr, Dept 162, San Diego, CA 92106 USA. [Taylor, Marcus K.] USN, Aerosp Med Res Lab, Pensacola, FL USA. [Pietrobon, Ricardo; Gandhi, Mihir] Duke Univ, Durham, NC USA. RP Momen, N (reprint author), USN, Hlth Res Ctr, Dept 162, 140 Sylvester Rd, San Diego, CA 92106 USA. EM Nausheen.Momen@med.navy.mil NR 18 TC 4 Z9 4 U1 2 U2 5 PU LAWRENCE ERLBAUM ASSOC INC-TAYLOR & FRANCIS PI PHILADELPHIA PA 325 CHESTNUT STREET, STE 800, PHILADELPHIA, PA 19106 USA SN 0899-5605 J9 MIL PSYCHOL JI Milit. Psychol. PY 2010 VL 22 IS 2 BP 128 EP 142 AR PII 920991906 DI 10.1080/08995601003638942 PG 15 WC Psychology, Multidisciplinary SC Psychology GA 595ZT UT WOS:000277653700004 ER PT J AU Mohr, SB Gorham, ED Garland, CF Grant, WB Garland, FC AF Mohr, Sharif B. Gorham, Edward D. Garland, Cedric F. Grant, William B. Garland, Frank C. TI Low Ultraviolet B and Increased Risk of Brain Cancer: An Ecological Study of 175 Countries SO NEUROEPIDEMIOLOGY LA English DT Article DE Brain neoplasms; Vitamin D; Ultraviolet rays; Alcohol; Cigarettes; Multiple regression; International comparisons ID VITAMIN-D-RECEPTOR; CENTRAL NERVOUS SYSTEM; BREAST-CANCER; PLASMA 25-HYDROXYVITAMIN-D; SERUM 25-HYDROXYVITAMIN-D; TOXOPLASMA-GONDII; OVARIAN-CANCER; GROWTH-FACTORS; D METABOLITES; COLON-CANCER AB Background: The purpose of this study was to determine whether an inverse association exists between latitude, solar ultraviolet B (UVB) irradiance, modeled 25-hydroxyvitamin D [25(OH)D] levels and incidence rates of cancer of the brain. Methods: Associations of latitude and UVB irradiance with age-standardized incidence rates of cancer of the brain were analyzed for 175 countries while controlling for proportion of population overweight, energy from animal sources, fish consumption, cigarette and alcohol consumption and per capita health expenditures, using multiple regression. Serum 25(OH)D levels were modeled for each country, and their association with brain cancer also was determined. Results: The incidence rates of brain cancer were higher at higher latitudes (R(2) for males = 0.45, p <= 0.0001; R(2) for females = 0.35, p < 0.0001). After adjustment for potential confounders, UVB irradiance (p <= 0.0001) and modeled serum 25(OH)D were inversely associated with incidence rates. Conclusions: Countries with low solar UVB irradiance and estimated mean serum 25(OH)D levels generally had higher age-standardized incidence rates of brain cancer. Since this was an ecological study, further research would be worthwhile on the association of prediagnostic serum 25(OH)D with incidence rate in studies of cohorts of individuals. Copyright (C) 2010 S. Karger AG, Basel C1 [Mohr, Sharif B.; Gorham, Edward D.; Garland, Frank C.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Mohr, Sharif B.; Gorham, Edward D.; Garland, Cedric F.; Garland, Frank C.] Univ Calif San Diego, Dept Family & Prevent Med 0620, La Jolla, CA 92093 USA. [Grant, William B.] Sunlight Nutr & Hlth Res Ctr, San Francisco, CA USA. RP Garland, CF (reprint author), Univ Calif San Diego, Dept Family & Prevent Med, 9500 Gilman Dr 0620, La Jolla, CA 92093 USA. EM cgarland@ucsd.edu RI Grant, William/B-8311-2009 OI Grant, William/0000-0002-1439-3285 FU Department of the Navy, Bureau of Medicine and Surgery [60126] FX This research was supported by a Congressional allocation to the Penn State Cancer Institute of the Hershey Medical Center, Hershey, Pa., USA, through the Department of the Navy, Bureau of Medicine and Surgery, under work unit No. 60126 at the Naval Health Research Center (San Diego, Calif., USA). The views expressed in this report are those of the authors and do not represent an official position of the Department of the Navy, Department of Defense or the US Government. NR 62 TC 11 Z9 11 U1 0 U2 0 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0251-5350 J9 NEUROEPIDEMIOLOGY JI Neuroepidemiology PY 2010 VL 35 IS 4 BP 281 EP 290 DI 10.1159/000314350 PG 10 WC Public, Environmental & Occupational Health; Clinical Neurology SC Public, Environmental & Occupational Health; Neurosciences & Neurology GA 683AM UT WOS:000284444100008 PM 20948235 ER PT S AU DelBalzo, DR Leclere, JH Klicka, J AF DelBalzo, Donald R. Leclere, James H. Klicka, Joseph GP IEEE TI Impact of Extended-Life Noise and Temperature Measurements on Littoral ASW SO OCEANS 2010 SE OCEANS-IEEE LA English DT Proceedings Paper CT Washington State Conference and Trade Center (WSCTC) CY SEP 20-23, 2010 CL Seattle, WA SP IEEE, Marine Technol, OES AB The U. S. Naval Air Systems Command is considering extended-life environmental sonobuoy concepts to better characterize littoral environments. Some conceptual designs contain thermistors to measure ocean temperatures and hydrophones to measure ambient noise. In this work, measured temperature profiles and predictions of ambient noise using ship densities in the Sea of Japan are used to simulate a) data collected with 3 "single-shot" fixed sonobuoys, b) data collected with 3 extended-life sonobuoys drifting over a 12-days, and c) "ground-truth" or actual conditions. Those environmental simulations are used to predict acoustic conditions; i.e., transmission loss, detection range, and detection probability at 100 Hz for an anti-submarine warfare application. The simulated environmental fields and predicted acoustic results for fixed and drifting sensors are compared to our best estimate of actual conditions. Results show that 3 drifting buoys yield significantly better representations of the actual temperatures, ambient noise, and derived acoustic fields than 3 discrete measurements. Intelligent algorithms are used to locate tactical sonobuoys in the three environments. The calculated detection probabilities from the drifting buoy environment are 20% more accurate than those from the discretely measured environment. C1 [DelBalzo, Donald R.; Leclere, James H.] QinetiQ N Amer, Technol Solut Grp, 40201 Hwy 190 E, Slidell, LA 70461 USA. [Klicka, Joseph] Naval Air Syst Command, PMA 264, Patuxent River, MD 20670 USA. RP DelBalzo, DR (reprint author), QinetiQ N Amer, Technol Solut Grp, 40201 Hwy 190 E, Slidell, LA 70461 USA. FU Naval Air Systems Command FX This on-going work was sponsored by the Naval Air Systems Command. NR 0 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0197-7385 BN 978-1-4244-4333-8 J9 OCEANS-IEEE PY 2010 PG 5 WC Acoustics; Engineering, Electrical & Electronic; Oceanography SC Acoustics; Engineering; Oceanography GA BTO61 UT WOS:000287539100105 ER PT J AU Hooper, TI Gackstetter, GD LeardMann, CA Boyko, EJ Pearse, LA Smith, B Amoroso, PJ Smith, TC AF Hooper, Tomoko I. Gackstetter, Gary D. LeardMann, Cynthia A. Boyko, Edward J. Pearse, Lisa A. Smith, Besa Amoroso, Paul J. Smith, Tyler C. CA Millennium Cohort Study Team TI Early mortality experience in a large military cohort and a comparison of mortality data sources SO POPULATION HEALTH METRICS LA English DT Article ID NATIONAL-DEATH-INDEX; OF-VETERANS-AFFAIRS; VITAL STATUS; MILLENNIUM COHORT; ASCERTAINMENT; DATABASES; HEALTH; VACCINATION; POPULATION; VALIDATION AB Background: Complete and accurate ascertainment of mortality is critically important in any longitudinal study. Tracking of mortality is particularly essential among US military members because of unique occupational exposures (e. g., worldwide deployments as well as combat experiences). Our study objectives were to describe the early mortality experience of Panel 1 of the Millennium Cohort, consisting of participants in a 21-year prospective study of US military service members, and to assess data sources used to ascertain mortality. Methods: A population-based random sample (n = 256,400) of all US military service members on service rosters as of October 1, 2000, was selected for study recruitment. Among this original sample, 214,388 had valid mailing addresses, were not in the pilot study, and comprised the group referred to in this study as the invited sample. Panel 1 participants were enrolled from 2001 to 2003, represented all armed service branches, and included active-duty, Reserve, and National Guard members. Crude death rates, as well as age-and sex-adjusted overall and age-adjusted, category-specific death rates were calculated and compared for participants (n = 77,047) and non-participants (n = 137,341) based on data from the Social Security Administration Death Master File, Department of Veterans Affairs (VA) files, and the Department of Defense Medical Mortality Registry, 2001-2006. Numbers of deaths identified by these three data sources, as well as the National Death Index, were compared for 2001-2004. Results: There were 341 deaths among the participants for a crude death rate of 80.7 per 100,000 person-years (95% confidence interval [CI]: 72.2,89.3) compared to 820 deaths and a crude death rate of 113.2 per 100,000 person-years (95% CI: 105.4, 120.9) for non-participants. Age-adjusted, category-specific death rates highlighted consistently higher rates among study non-participants. Although there were advantages and disadvantages for each data source, the VA mortality files identified the largest number of deaths (97%). Conclusions: The difference in crude and adjusted death rates between Panel 1 participants and non-participants may reflect healthier segments of the military having the opportunity and choosing to participate. In our study population, mortality information was best captured using multiple data sources. C1 [Hooper, Tomoko I.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Gackstetter, Gary D.] Analyt Serv Inc, Arlington, VA USA. [LeardMann, Cynthia A.; Smith, Besa; Smith, Tyler C.] USN, Hlth Res Ctr, Dept Def Ctr Deployment Hlth Res, San Diego, CA 92152 USA. [Boyko, Edward J.] Dept Vet Affairs Puget Sound Hlth Care Syst, Seattle Epidemiol Res & Informat Ctr, Seattle, WA USA. [Pearse, Lisa A.] Armed Forces Med Examiner Syst, Mortal Surveillance Div, Rockville, MD USA. [Amoroso, Paul J.] Madigan Army Med Ctr, Ft Lewis, WA USA. RP Hooper, TI (reprint author), Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. EM thooper@usuhs.mil NR 33 TC 6 Z9 6 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1478-7954 J9 POPUL HEALTH METR JI Popul. Health Metr. PY 2010 VL 8 AR 15 DI 10.1186/1478-7954-8-15 PG 13 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA V21QF UT WOS:000208221400015 PM 20492737 ER PT S AU Mutschler, DW AF Mutschler, David W. BE Johansson, B Jain, S MontoyaTorres, J Hugan, J Yucesan, E TI EMPLOYING PROXIES TO IMPROVE PARALLEL DISCRETE EVENT SIMULATION PERFORMANCE SO PROCEEDINGS OF THE 2010 WINTER SIMULATION CONFERENCE SE Winter Simulation Conference Proceedings LA English DT Proceedings Paper CT 2010 Winter Simulation Conference CY DEC 05-08, 2010 CL Baltimore, MD SP IEEE, ASA, ACM/SIGSIM, IEEE/SMC, IIE, INFORMS-SIM, NIST, SCS AB Proxies are caches of information maintained by one simulation object about other simulation objects. Though proxies can require significant overhead to maintain consistency, their judicious use can improve parallel performance by increasing speedup. This paper discusses three cases where careful use of proxies has improved speedup in a parallel discrete event simulator implemented using threaded worker pools. C1 Naval Air Syst Command, Patuxent River, MD 20670 USA. RP Mutschler, DW (reprint author), Naval Air Syst Command, 22595 Saufley Rd,Bldg 3259, Patuxent River, MD 20670 USA. EM david.mutschler@navy.mil NR 5 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0891-7736 BN 978-1-4244-9864-2 J9 WINT SIMUL C PROC PY 2010 BP 1512 EP 1521 DI 10.1109/WSC.2010.5679041 PG 10 WC Computer Science, Interdisciplinary Applications; Engineering, Manufacturing; Mathematical & Computational Biology; Operations Research & Management Science; Mathematics, Applied SC Computer Science; Engineering; Mathematical & Computational Biology; Operations Research & Management Science; Mathematics GA BTS41 UT WOS:000287976701070 ER PT B AU Minnick, L Bassler, C Percival, S Hanyok, L AF Minnick, Lisa Bassler, Christopher Percival, Scott Hanyok, Lauren GP ASME TI LARGE-SCALE WAVE KINEMATICS MEASUREMENTS OF REGULAR WAVES AND LARGE-AMPLITUDE WAVE GROUPS SO PROCEEDINGS OF THE ASME 29TH INTERNATIONAL CONFERENCE ON OCEAN, OFFSHORE AND ARCTIC ENGINEERING, 2010, VOL 4 LA English DT Proceedings Paper CT 29th ASME International Conference on Ocean, Offshore and Arctic Engineering CY JUN 06-11, 2010 CL Shanghai, PEOPLES R CHINA SP ASME, Ocean, Offshore, & Arctic Engn Div ID DEEP-WATER; ACCELERATIONS AB An experiment was performed to measure and characterize wave kinematics in an experimental basin. The experiment is part of an ongoing effort to improve predictions and measurements of ship motions in waves, including more accurate characterization of the near-field wave environment and its influence on ship motions. The primary objective of this experiment was to measure and characterize the wave kinematics of regular waves of varying steepness and scaled irregular seaways, including irregular waves with embedded wave groups. Measurements, including free-surface elevations and velocity field measurements under the free surface, are presented and discussed. C1 [Minnick, Lisa; Bassler, Christopher; Percival, Scott; Hanyok, Lauren] Naval Surface Warfare Ctr, Carderock Div, Carderock, MD USA. RP Minnick, L (reprint author), Naval Surface Warfare Ctr, Carderock Div, Carderock, MD USA. NR 24 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4912-5 PY 2010 BP 147 EP 158 PG 12 WC Engineering, Ocean; Engineering, Mechanical SC Engineering GA BUY37 UT WOS:000290693600019 ER PT J AU Nozette, S Spudis, P Bussey, B Jensen, R Raney, K Winters, H Lichtenberg, CL Marinelli, W Crusan, J Gates, M Robinson, M AF Nozette, Stewart Spudis, Paul Bussey, Ben Jensen, Robert Raney, Keith Winters, Helene Lichtenberg, Christopher L. Marinelli, William Crusan, Jason Gates, Michele Robinson, Mark TI The Lunar Reconnaissance Orbiter Miniature Radio Frequency (Mini-RF) Technology Demonstration SO SPACE SCIENCE REVIEWS LA English DT Review DE Lunar Reconnaissance Orbiter; Mini RF; Lunar poles ID SOUTH-POLE; RADAR EXPERIMENT; ICE; DEPOSITS; MOON; SAR AB The Miniature Radio Frequency (Mini-RF) system is manifested on the Lunar Reconnaissance Orbiter (LRO) as a technology demonstration and an extended mission science instrument. Mini-RF represents a significant step forward in spaceborne RF technology and architecture. It combines synthetic aperture radar (SAR) at two wavelengths (S-band and X-band) and two resolutions (150 m and 30 m) with interferometric and communications functionality in one lightweight (16 kg) package. Previous radar observations (Earth-based, and one bistatic data set from Clementine) of the permanently shadowed regions of the lunar poles seem to indicate areas of high circular polarization ratio (CPR) consistent with volume scattering from volatile deposits (e.g. water ice) buried at shallow (0.1-1 m) depth, but only at unfavorable viewing geometries, and with inconclusive results. The LRO Mini-RF utilizes new wideband hybrid polarization architecture to measure the Stokes parameters of the reflected signal. These data will help to differentiate "true" volumetric ice reflections from "false" returns due to angular surface regolith. Additional lunar science investigations (e.g. pyroclastic deposit characterization) will also be attempted during the LRO extended mission. LRO's lunar operations will be contemporaneous with India's Chandrayaan-1, which carries the Forerunner Mini-SAR (S-band wavelength and 150-m resolution), and bistatic radar (S-Band) measurements may be possible. On orbit calibration, procedures for LRO Mini-RF have been validated using Chandrayaan 1 and ground-based facilities (Arecibo and Greenbank Radio Observatories). C1 [Bussey, Ben; Jensen, Robert; Raney, Keith; Winters, Helene] Appl Phys Lab, Laurel, MD 20723 USA. [Nozette, Stewart; Spudis, Paul] Lunar & Planetary Inst, Houston, TX 77058 USA. [Lichtenberg, Christopher L.] USN, Air Warfare Ctr, China Lake, CA 93555 USA. [Marinelli, William; Crusan, Jason; Gates, Michele] NASA, Washington, DC 20546 USA. [Robinson, Mark] Arizona State Univ, Tempe, AZ USA. RP Bussey, B (reprint author), Appl Phys Lab, Laurel, MD 20723 USA. EM Ben.Bussey@jhuapl.edu NR 18 TC 54 Z9 58 U1 0 U2 15 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0038-6308 J9 SPACE SCI REV JI Space Sci. Rev. PD JAN PY 2010 VL 150 IS 1-4 BP 285 EP 302 DI 10.1007/s11214-009-9607-5 PG 18 WC Astronomy & Astrophysics SC Astronomy & Astrophysics GA 573JG UT WOS:000275908700012 ER PT J AU Davis, MC Baldwin, LC AF Davis, Matthew C. Baldwin, Lawrence C. TI Alternative Route to the Diisocyanate Building Block 1,4-Diisocyanato-4-methylpentane (DIMP) SO SYNTHETIC COMMUNICATIONS LA English DT Article DE Curtius reaction; dicarboxylic acid; diisocyanate; dinitrile AB The synthesis of 1,4-diisocyanato-4-methylpentane was accomplished starting from isobutyronitrile in six steps with 53% overall yield. The two isocyanates were installed by a double Curtius rearrangement. The product reacts with alcohol in a regioselective manner. C1 [Davis, Matthew C.; Baldwin, Lawrence C.] USN, Chem & Mat Div, Michelson Lab, Air Warfare Ctr, China Lake, CA 93555 USA. RP Davis, MC (reprint author), USN, Chem & Mat Div, Michelson Lab, Air Warfare Ctr, China Lake, CA 93555 USA. EM matthew.davis@navy.mil FU Army Research Laboratory FX The generous financial support from the Army Research Laboratory is gratefully acknowledged. Thanks to Ann M. Moorehead of the Technical Library for obtaining Ref. 1. NR 17 TC 0 Z9 0 U1 1 U2 1 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0039-7911 J9 SYNTHETIC COMMUN JI Synth. Commun. PY 2010 VL 40 IS 10 BP 1437 EP 1444 AR PII 921552219 DI 10.1080/00397910903097278 PG 8 WC Chemistry, Organic SC Chemistry GA 597EH UT WOS:000277738700003 ER PT J AU Davis, MC Groshens, TJ Parrish, DA AF Davis, Matthew C. Groshens, Thomas J. Parrish, Damon A. TI Preparation of Cyan Dyes from 6-Diethylaminobenzo[b]furan-2-carboxaldehyde SO SYNTHETIC COMMUNICATIONS LA English DT Article DE Benzofuran; dyes; malononitrile dimer; polyene ID NONLINEAR-OPTICAL CHROMOPHORES; MALONONITRILE DIMER; FACILE SYNTHESIS; ISOPHORONE AB 6-Diethylaminobenzo[b]furan-2-carboxaldehyde was synthesized in four steps and 48% overall yield starting from 4-diethylaminosalicylaldehyde. Five cyan dyes were made from this aldehyde using malononitrile dimer and 2-dicyanomethylene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran. The crystal structures of two dyes are included. C1 [Davis, Matthew C.; Groshens, Thomas J.] USN, Chem & Mat Div, Michelson Lab, Air Warfare Ctr, China Lake, CA 93555 USA. [Parrish, Damon A.] USN, Struct Matter Lab, Res Lab, Washington, DC USA. RP Davis, MC (reprint author), USN, Chem & Mat Div, Michelson Lab, Air Warfare Ctr, China Lake, CA 93555 USA. EM matthew.davis@navy.mil NR 29 TC 3 Z9 3 U1 1 U2 7 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0039-7911 J9 SYNTHETIC COMMUN JI Synth. Commun. PY 2010 VL 40 IS 20 BP 3008 EP 3020 AR PII 926886368 DI 10.1080/00397910903351568 PG 13 WC Chemistry, Organic SC Chemistry GA 650SP UT WOS:000281872900006 ER PT B AU Gorham, ED Mohr, SB Garland, FC Garland, CF AF Gorham, Edward D. Mohr, Sharif B. Garland, Frank C. Garland, Cedric F. BE Holick, MF TI Vitamin D for Cancer Prevention and Survival SO VITAMIN D: PHYSIOLOGY, MOLECULAR BIOLOGY, AND CLINICAL APPLICATIONS, SECOND EDITION SE Nutrition and Health Series LA English DT Article; Book Chapter DE Vitamin D; 25-hydroxyvitamin D; breast neoplasms; colonic neoplasms; ovarian neoplasms; dose response; pathogenesis; prevention ID ULTRAVIOLET-B IRRADIANCE; SERUM 25-HYDROXYVITAMIN-D LEVELS; AFRICAN-AMERICAN WOMEN; MAMMARY STEM-CELLS; BREAST-CANCER; COLORECTAL-CANCER; COLON-CANCER; D SUPPLEMENTATION; MORTALITY-RATES; OVARIAN-CANCER AB Higher levels of the principal circulating form of vitamin D, 25-hydroxyvitamin D [25(OH)D], are associated with substantially lower incidence and death rates from colon, breast, and ovarian cancer, with a linear dose response gradient. The accumulated evidence from observational studies and a randomized trial reveal that population serum levels of 25(OH)D in the range of 40-60 ng/ml will markedly reduce incidence and mortality rates of several cancers including those of the breast, colon, and ovary. There is an immediate clinical need for cancer care providers worldwide to assure that a serum 25(OH)D level > 40 ng/ml is achieved as soon as feasible after diagnosis of patients with breast and colon cancer, unless specifically contraindicated by preexisting. hypercalcemia. This serum target could he revisited after further rigorous studies are performed, but the evidence that has accumulated during the past 30 years is sufficiently strong now to adopt the above dosages and serum targets for professional and public health action. Such prompt action is likely to cut mortality from these cancers by half within approximately 5 years. Research on a wider range of cancer types with higher scrum 25(OH)D levels (>= 50 ng/ml or 125 nmol/l) is needed. In the meantime, vitamin D-3 intake by everyone in the continental United States and Canada aged I year and older should be no less than 2,000 IU/day of vitamin D-3 and 1,000 IU/day for infants. C1 [Gorham, Edward D.; Mohr, Sharif B.; Garland, Frank C.; Garland, Cedric F.] Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA. [Gorham, Edward D.; Mohr, Sharif B.; Garland, Frank C.; Garland, Cedric F.] USN, Hlth Res Ctr, San Diego, CA 92106 USA. RP Gorham, ED (reprint author), Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA. NR 131 TC 1 Z9 1 U1 0 U2 1 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA BN 978-1-60327-300-8 J9 NUTR HEALTH SER JI Nutr. Health Ser. PY 2010 BP 813 EP 840 DI 10.1007/978-1-60327-303-9_44 D2 10.1007/978-1-60327-303-9 PG 28 WC Nutrition & Dietetics SC Nutrition & Dietetics GA BOR11 UT WOS:000277365800044 ER PT J AU Crum-Cianflone, NF Blair, PJ Faix, D Arnold, J Echols, S Sherman, SS Tueller, JE Warkentien, T Sanguineti, G Bavaro, M Hale, BR AF Crum-Cianflone, Nancy F. Blair, Patrick J. Faix, Dennis Arnold, John Echols, Sara Sherman, Sterling S. Tueller, John E. Warkentien, Tyler Sanguineti, Gabriela Bavaro, Mary Hale, Braden R. TI Clinical and Epidemiologic Characteristics of an Outbreak of Novel H1N1 (Swine Origin) Influenza A Virus among United States Military Beneficiaries SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID PANDEMIC INFLUENZA; SEASONAL INFLUENZA; APRIL-MAY; HUMANS; INFECTION; TRANSMISSIBILITY; SURVEILLANCE; VACCINATION; CALIFORNIA; WISCONSIN AB Background. A novel swine-origin influenza A (H1N1) virus was identified in March 2009 and subsequently caused worldwide outbreaks. The San Diego region was an early focal point of the emerging pandemic. We describe the clinical and epidemiologic characteristics of this novel strain in a military population to assist in future outbreak prevention and control efforts. Methods. We performed an epidemiologic evaluation of novel H1N1 virus infections diagnosed in San Diego County among 96,258 local US military beneficiaries. The structured military medical system afforded the ability to obtain precise epidemiologic information on the impact on H1N1 virus infection in a population. The novel H1N1 virus was confirmed using real-time reverse transcriptase polymerase chain reaction (rRT-PCR). Results. From 21 April through 8 May 2009, 761 patients presented with influenza-like illness and underwent rRT-PCR testing. Of these patients, 97 had confirmed novel H1N1 virus infection, with an incidence rate of 101 cases per 100,000 persons. The median age of H1N1 patients with H1N1 virus infection was 21 years (interquartile range, 15-25 years). Fever was a universal symptom in patients with H1N1 virus infection; other symptoms included cough (present in 96% of patients), myalgia or arthralgia (57%), and sore throat (51%). Sixty-eight (70%) of our patients had an identifiable epidemiologic link to another confirmed patient. The largest cluster of cases of H1N1 virus infection occurred on a Navy ship and involved 32 (8%) of 402 crew members; the secondary attack rate was 6%-14%. The rapid influenza testing that was used during this outbreak had a sensitivity of 51% and specificity of 98%, compared with rRT-PCR. Only 1 patient was hospitalized, and there were no deaths. Conclusions. A novel H1N1 influenza A virus caused a significant outbreak among military beneficiaries in San Diego County, including a significant cluster of cases onboard a Navy ship. The outbreak described here primarily affected adolescents and young adults and resulted in a febrile illness without sequelae. C1 [Crum-Cianflone, Nancy F.; Echols, Sara; Warkentien, Tyler; Sanguineti, Gabriela; Bavaro, Mary; Hale, Braden R.] USN, San Diego Med Ctr, Infect Dis Clin, San Diego, CA 92134 USA. [Arnold, John] USN, San Diego Med Ctr, Dept Pediat, San Diego, CA 92134 USA. [Sherman, Sterling S.; Tueller, John E.] USN, San Diego Med Ctr, Dept Prevent Med, San Diego, CA 92134 USA. [Blair, Patrick J.; Faix, Dennis] USN, Hlth Res Ctr, San Diego, CA 92134 USA. [Crum-Cianflone, Nancy F.; Echols, Sara; Sanguineti, Gabriela; Hale, Braden R.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. RP Hale, BR (reprint author), USN, San Diego Med Ctr, Infect Dis Clin, 34800 Bob Wilson Dr,Ste 5, San Diego, CA 92134 USA. EM braden.hale@med.navy.mil RI Valle, Ruben/A-7512-2013; Chiang, Vincent, Ming-Hsien/D-4312-2016 OI Chiang, Vincent, Ming-Hsien/0000-0002-2029-7863 FU US Department of Defense Global Emerging Infections Surveillance and Response System; Infectious Disease Clinical Research Program; Uniformed Services University of the Health Sciences; National Institute of Allergy and Infectious Diseases; National Institutes of Health [Y1-AI-5072] FX US Department of Defense Global Emerging Infections Surveillance and Response System; the Infectious Disease Clinical Research Program, a Department of Defense program executed through the Uniformed Services University of the Health Sciences; and the National Institute of Allergy and Infectious Diseases, National Institutes of Health (interagency agreement Y1-AI-5072). NR 35 TC 68 Z9 68 U1 1 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD DEC 15 PY 2009 VL 49 IS 12 BP 1801 EP 1810 DI 10.1086/648508 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 523KA UT WOS:000272070800005 PM 19911946 ER PT J AU Smith, B Wong, CA Smith, TC Boyko, EJ Gackstetter, GD Ryan, MAK AF Smith, Besa Wong, Charlene A. Smith, Tyler C. Boyko, Edward J. Gackstetter, Gary D. Ryan, Margaret A. K. CA Millennium Cohort Study Team TI Newly Reported Respiratory Symptoms and Conditions Among Military Personnel Deployed to Iraq and Afghanistan: A Prospective Population-based Study SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Article DE longitudinal studies; lung diseases; military personnel; signs and symptoms; respiratory ID GULF-WAR VETERANS; OBSTRUCTIVE PULMONARY-DISEASE; CHARACTERIZING MINERAL DUSTS; MILLENNIUM COHORT; HEALTH-STATUS; US MILITARY; OCCUPATIONAL DUST; EXPOSURE; PREVALENCE; ILLNESS AB Concerns about respiratory conditions have surfaced among persons deployed to Iraq and Afghanistan. Data on 46,077 Millennium Cohort Study participants who completed baseline (July 2001-June 2003) and follow-up (June 2004-February 2006) questionnaires were used to investigate 1) respiratory symptoms (persistent or recurring cough or shortness of breath), 2) chronic bronchitis or emphysema, and 3) asthma. Deployers had a higher rate of newly reported respiratory symptoms than nondeployers (14% vs. 10%), while similar rates of chronic bronchitis or emphysema (1% vs. 1%) and asthma (1% vs. 1%) were observed. Deployment was associated with respiratory symptoms in both Army (adjusted odds ratio = 1.73, 95% confidence interval: 1.57, 1.91) and Marine Corps (adjusted odds ratio = 1.49, 95% confidence interval: 1.06, 2.08) personnel, independently of smoking status. Deployment length was linearly associated with increased symptom reporting in Army personnel (P < 0.0001). Among deployers, elevated odds of symptoms were associated with land-based deployment as compared with sea-based deployment. Although respiratory symptoms were associated with deployment, inconsistency in risk with cumulative exposure time suggests that specific exposures rather than deployment in general are determinants of postdeployment respiratory illness. Significant associations seen with land-based deployment also imply that exposures related to ground combat may be important. C1 [Smith, Besa; Wong, Charlene A.; Smith, Tyler C.] USN, Dept Def, Ctr Deployment Hlth Res, Hlth Res Ctr, San Diego, CA 92106 USA. [Boyko, Edward J.] Seattle Epidemiol Res & Informat Ctr, Dept Vet Affairs Puget Sound Healthcare Syst, Seattle, WA USA. [Gackstetter, Gary D.] Analyt Serv Inc, Arlington, VA USA. [Gackstetter, Gary D.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Ryan, Margaret A. K.] USN, Dept Occupat Hlth, Hosp Camp Pendleton, Camp Pendleton, CA USA. RP Smith, B (reprint author), USN, Dept Def, Ctr Deployment Hlth Res, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. EM besa.smith@med.navy.mil FU US Department of Defense; Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland.; [NHRC.2000.007] FX This research (Naval Health Research Center report 08-33) was supported by the US Department of Defense and was conducted in compliance with all applicable federal regulations governing the protection of human subjects in research (protocol NHRC.2000.007). Additional support was provided by the Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland. NR 47 TC 61 Z9 61 U1 2 U2 9 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD DEC 1 PY 2009 VL 170 IS 11 BP 1433 EP 1442 DI 10.1093/aje/kwp287 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 523JR UT WOS:000272069900014 PM 19850627 ER PT J AU McLay, RN Spira, JL AF McLay, Robert N. Spira, James L. TI Use of a Portable Biofeedback Device to Improve Insomnia in a Combat Zone, a Case Report SO APPLIED PSYCHOPHYSIOLOGY AND BIOFEEDBACK LA English DT Article DE Anxiety; Combat disorders; Depression; Post traumatic stress disorder; Sleep; War ID SLEEP; VARIABILITY; DISORDER; PTSD; WAR AB Insomnia is a common problem in situations of stress. Some forms of stress, however, may contraindicate the use of traditional, pharmacological interventions. Working in a combat zone is such a situation. Alternative means of improving sleep are clearly needed for Service Members. We report a case involving a medical provider who was serving in a military, emergency-services facility in Iraq, and who presented with anxiety, depressed mood, and insomnia. Symptoms were sub-threshold for major depressive disorder or acute stress disorder. Mood and anxiety symptoms responded to traditional therapy techniques, but problems with insomnia remained. The patient was given a portable biofeedback device that employs an infrared sensor photoplethysmograph to measure heart rate variability (HRV) from peripheral finger pulse. One week later, sleep was significantly improved. Symptom improvement lasted to at least 6 weeks while in theater. One year later, a check-in with the patient revealed that after returning home, he had been diagnosed with post traumatic stress disorder (PTSD). PTSD symptoms had resolved after 6 months of psychopharmacology and cognitive behavioral therapy. These results indicate that biofeedback may be a useful means of improving sleep in a combat zone, but that such improvements may not necessarily prevent the development of more serious symptoms later. No clear causality can be inferred from a single case, and further study is needed to determine if this finding have wider applicability. C1 [McLay, Robert N.; Spira, James L.] USN, San Diego Med Ctr, Clin Invest Dept KCA, San Diego, CA 92134 USA. [Spira, James L.] RTI Internat, Unit 5, San Diego, CA 92130 USA. [McLay, Robert N.] Naval Medical Center San Diego, Clin Investigat Department KCA, San Diego, CA 92134 USA. RP McLay, RN (reprint author), USN, San Diego Med Ctr, Clin Invest Dept KCA, 34800 Bob Wilson Dr,Ste 5, San Diego, CA 92134 USA. EM rmclay1@yahoo.com NR 16 TC 13 Z9 14 U1 3 U2 13 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1090-0586 J9 APPL PSYCHOPHYS BIOF JI Appl. Psychophysiol. Biofeedback PD DEC PY 2009 VL 34 IS 4 BP 319 EP 321 DI 10.1007/s10484-009-9104-3 PG 3 WC Psychology, Clinical SC Psychology GA 524QR UT WOS:000272158300008 PM 19655243 ER PT J AU Ding, HP Chen, G Majumdar, AK Sadler, BM Xu, ZY AF Ding, Haipeng Chen, Gang Majumdar, Arun K. Sadler, Brian M. Xu, Zhengyuan TI Modeling of Non-Line-of-Sight Ultraviolet Scattering Channels for Communication SO IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS LA English DT Article DE Multiple scattering; non-line-of-sight; ultraviolet; Monte Carlo; photon tracing ID LIGHT-EMITTING-DIODES; AVALANCHE PHOTODIODES; PERFORMANCE; ATMOSPHERE; AUREOLE AB A stochastic non-line-of-sight (NLOS) ultraviolet (UV) communication channel model is developed using a Monte Carlo simulation method based on photon tracing. The expected channel impulse response is obtained by computing photon arrival probabilities and associated propagation delay at the receiver. This method captures the multiple scattering effects of UV signal propagation in the atmosphere, and relaxes the assumptions of single scattering theory. The proposed model has a clear advantage in reliable prediction of NLOS path loss, as validated by outdoor experiments at small to medium elevation angles. A Gamma function is shown to agree well with the predicted impulse response, and this provides a simple means to determine the channel bandwidth. The developed model is employed to study the characteristics of NLOS UV scattering channels, including path loss and channel bandwidth, for a variety of scattering conditions, source wavelength, transmitter and receiver optical pointing geometries, and range. C1 [Ding, Haipeng; Chen, Gang; Xu, Zhengyuan] Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. [Majumdar, Arun K.] USN, Air Warfare Ctr, Weap Div, China Lake, CA 93555 USA. [Sadler, Brian M.] USA, Res Lab, RDRL CIN T, Adelphi, MD 20783 USA. RP Ding, HP (reprint author), Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. EM arun.majumdar@navy.mil; bsadler@arl.army.mil; dxu@ee.ucr.edu RI Ding, Haipeng/B-7742-2014 FU Army Research Office [W911NF-06-1-0364, W911NF-06-1-0173]; Army Research Laboratory [DAAD19-01-2-0011] FX This work was supported in part by the Army Research Office under Grants W911NF-06-1-0364 and W911NF-06-1-0173, and the Army Research Laboratory under the Collaborative Technology Alliance Program, Cooperative Agreement DAAD19-01-2-0011. NR 32 TC 100 Z9 114 U1 3 U2 13 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0733-8716 J9 IEEE J SEL AREA COMM JI IEEE J. Sel. Areas Commun. PD DEC PY 2009 VL 27 IS 9 BP 1535 EP 1544 DI 10.1109/JSAC.2009.091203 PG 10 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 526SX UT WOS:000272315200003 ER PT J AU Sliman, JA Metzgar, D Asseff, DC Coon, RG Faix, DJ Lizewski, S AF Sliman, Joseph A. Metzgar, David Asseff, David C. Coon, Robert G. Faix, Dennis J. Lizewski, Stephen TI Outbreak of Acute Respiratory Disease Caused by Mycoplasma pneumoniae on Board a Deployed US Navy Ship SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID CRUISE SHIPS; INFLUENZA; PCR; IDENTIFICATION; INFECTIONS AB We identified 179 cases of acute respiratory illness including 50 cases of radiographically confirmed pneumonia over the course of 4 months on a deployed U. S. Navy vessel. Laboratory tests showed Mycoplasma pneumoniae to be the etiological agent. This report represents the first published description of a shipboard outbreak of this pathogen. C1 [Metzgar, David; Coon, Robert G.; Faix, Dennis J.] USN, Hlth Res Ctr, Dept Resp Dis Res, San Diego, CA 92106 USA. [Sliman, Joseph A.; Faix, Dennis J.] USN, Environm & Prevent Med Unit 6, Honolulu, HI USA. [Asseff, David C.; Lizewski, Stephen] USN, Environm & Prevent Med Unit 5, San Diego, CA 92106 USA. RP Metzgar, D (reprint author), USN, Hlth Res Ctr, Dept Resp Dis Res Code 166, 140 Sylvester Rd, San Diego, CA 92106 USA. EM david.metzgar@med.navy.mil NR 25 TC 9 Z9 11 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD DEC PY 2009 VL 47 IS 12 BP 4121 EP 4123 DI 10.1128/JCM.01926-09 PG 3 WC Microbiology SC Microbiology GA 525QD UT WOS:000272230500047 PM 19846632 ER PT J AU Momen, N AF Momen, Nausheen TI The Effects of Alternative Input Devices and Repeated Exposures on the Test of Basic Aviation Skills (TBAS) Performance SO MILITARY MEDICINE LA English DT Article AB The use of computer-based, psychomotor testing systems for personnel selection and classification has gained popularity in the civilian and military worlds in recent years. However, several issues need to be resolved before adopting a computerized, psychomotor test. The purpose of this study was to compare the impact of alternative input devices used for the Test Of Basic Aviation Skills (TBAS) as well as to explore the practice effects of the TBAS. In study 1, participants were administered the TBAS tracking tests once with a throttle and once with foot pedals in a classic test retest paradigm. The results confirmed that neither of the input devices provided a significant advantage on TBAS performance. In study 2, participants were administered the TBAS twice with a 24-hour interval between testing. The results demonstrated significant practice effects for all the TBAS subtests except for the dichotic listening tests. C1 USN, Hlth Res Ctr, San Diego, CA 92106 USA. RP Momen, N (reprint author), USN, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. FU Naval Operational Medicine Institute (NOMI) [70408] FX Appreciation is extended to CAPT Dave Service for subject matter expert consultation. Appreciation is also extended to the students and staff at the Aviation Preflight Indoctrination School, NAS Pensacola, FL. This study was sponsored by the Naval Operational Medicine Institute (NOMI), Work Unit No. 70408. NR 13 TC 1 Z9 1 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2009 VL 174 IS 12 BP 1282 EP 1286 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 601LM UT WOS:000278061000024 PM 20055069 ER PT J AU Arnold, JC Singh, KK Milder, E Spector, SA Sawyer, MH Gavali, S Glaser, C AF Arnold, John C. Singh, Kumud K. Milder, Edmund Spector, Stephen A. Sawyer, Mark H. Gavali, Shilpa Glaser, Carol TI Human Metapneumovirus Associated With Central Nervous System Infection in Children SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE human metapneumovirus; encephalitis; seizures; pediatric ID RESPIRATORY-TRACT DISEASE; YOUNG-CHILDREN; ENCEPHALITIS; CALIFORNIA; ADULTS AB Background: Human metapneumovirus (hMPV) is an established pathogen of the respiratory tract of children and adults. hMPV is related to other paramyxoviruses known to cause encephalitis. Reports suggest that hMPV may cause disease of the central nervous system (CNS). Methods: Two groups of patients were studied. The first group consisted of children between birth and 18 years from whom nasal scrapings were obtained between January 2004 and October 2005. hMPV RNA amplification by PCR was done and records were reviewed for clinical and demographic data. The second group consisted of patients with encephalitis referred to the California Encephalitis Project (CEP) for comprehensive diagnostic testing between November 2004 and June 2006. Results: In group 1, 1474 specimens were examined for hMPV RNA. Sixty-three evaluable patients were infected with hMPV of whom 4 (6.3%) had seizures, compared with 145 patients infected with RSV of whom I had seizures (0.7%, P = 0.031). Comparing respiratory syncytial virus (RSV) and hMPV infections, there was no significant difference in the occurrence of fever. All children with hMPV infections and seizures were hospitalized and 3 were intubated because of status epilepticus. Group 2 consisted of 205 pediatric cases referred to CEP between November 2004 and June 2006 who had hMPV testing done. hMPV was detected in nasopharyngeal swabs of 5 patients. Neither hMPV RNA nor antihMPV specific IgM were detectable in the CSF from the 5 patients for whom CSF was available. Conclusion: Nine cases of CNS illness temporally associated with the presence of hMPV nucleic acid in the upper airway are described. Compared with children infected with RSV, children with hMPV were significantly more likely to have had a seizure. Our data, in conjunction with previously reported cases suggest that hMPV may be associated with a spectrum of CNS disease ranging from febrile seizures to severe, fatal encephalitis. C1 [Arnold, John C.; Milder, Edmund] USN, Med Ctr, Dept Pediat, Div Infect Dis, San Diego, CA 92152 USA. [Arnold, John C.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Singh, Kumud K.; Spector, Stephen A.; Sawyer, Mark H.] Univ Calif San Diego, Dept Pediat, Ctr AIDS Res, Div Infect Dis, San Diego, CA 92103 USA. [Gavali, Shilpa; Glaser, Carol] Ctr Infect Dis, Viral & Rickettsial Dis Lab, Calif Dept Publ Hlth, Berkeley, CA USA. RP Arnold, JC (reprint author), Childrens Hosp, Dept Infect Dis, 3020 Childrens Way,MC 5041, San Diego, CA 92123 USA. EM jcarnold@ucsd.edu FU Virology Core, Center for AIDS Research, University of California, San Diego, CA [AI-36214] FX Supported in part by AI-36214 (Virology Core, Center for AIDS Research, University of California, San Diego, CA). NR 20 TC 20 Z9 20 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD DEC PY 2009 VL 28 IS 12 BP 1057 EP 1060 DI 10.1097/INF.0b013e3181acd221 PG 4 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA 525OH UT WOS:000272225200004 PM 19755929 ER PT J AU Stoops, AC Barbara, KA Indrawan, M Ibrahim, IN Petrus, WB Wijaya, S Farzeli, A Antonjaya, U Sin, LW Hidayatullah, N Kristanto, I Tampubolon, AM Purnama, S Supriatna, A Burgess, TH Williams, M Putnam, SD Tobias, S Blair, PJ AF Stoops, Arthur C. Barbara, Katie A. Indrawan, Mochamad Ibrahim, Ima N. Petrus, Wicaksana B. Wijaya, Susan Farzeli, Arik Antonjaya, Ungke Sin, Lim W. Hidayatullah, N. Kristanto, Ige Tampubolon, A. M. Purnama, S. Supriatna, Adam Burgess, Timothy H. Williams, Maya Putnam, Shannon D. Tobias, Steve Blair, Patrick J. TI H5N1 Surveillance in Migratory Birds in Java, Indonesia SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Field studies; Influenza; Zoonosis ID PATHOGENIC AVIAN INFLUENZA; VIRUS-INFECTION; WILD BIRDS; NORTH-AMERICA; HONG-KONG; A VIRUS; HEMAGGLUTININ; EVOLUTION; ASIA; REEMERGENCE AB We sought to elucidate the role of migratory birds in transmission of H5N1 in an enzoonotic area. Resident, captive, and migratory birds were sampled at five sites in Java, Indonesia. Mist nets were used to trap birds. Birds were identified to species. RNA was extracted from swabs and reverse transcriptase polymerase chain reaction (RT-PCR) conducted for the HA and M genes of H5N1. Antibodies were detected by enzyme-linked immunosorbent assay and hemagglutination inhibition test. Between October 2006 and September 2007, a total of 4,067 captive, resident, and migratory birds comprising 98 species in 23 genera were sampled. The most commonly collected birds were the common sandpiper (6% of total), striated heron (3%), and the domestic chicken (14%). The overall prevalence of H5N1 antibodies was 5.3%. A significantly higher percentage of captive birds (16.1%) showed antibody evidence of H5N1 exposure when compared to migratory or resident birds. The greatest number of seropositive birds in each category were Muschovy duck (captive), striated heron (resident), and the Pacific golden plover (migratory). Seven apparently well captive birds yielded molecular evidence of H5N1 infection. Following amplification, the HA, NA, and M genes were analyzed. Phylogenetic analysis of the HA gene showed that the isolates were 97% similar to EU124153.1 A/chicken/West Java/Garut May 2006, an isolate obtained in a similar region of West Java. While no known markers of neuraminidase inhibitor resistance were found within the NA gene, M segment analysis revealed the V27A mutation known to confer resistance to adamantanes. Our results demonstrate moderate serologic evidence of H5N1 infection in captive birds, sampled in five sites in Java, Indonesia, but only occasional infection in resident and migratory birds. These data imply that in an enzoonotic region of Indonesia the role of migratory birds in transmission of H5N1 is limited. C1 [Stoops, Arthur C.; Barbara, Katie A.; Petrus, Wicaksana B.; Wijaya, Susan; Farzeli, Arik; Antonjaya, Ungke; Burgess, Timothy H.; Williams, Maya; Putnam, Shannon D.; Tobias, Steve; Blair, Patrick J.] Naval Med Res Unit 2, Jakarta, Indonesia. [Indrawan, Mochamad] PILI Pusat Informasi Lingkungan Hidup Indonesia, IdOU Indonesian Ornithol Union, Jawa Barat 16155, Indonesia. [Sin, Lim W.; Hidayatullah, N.; Kristanto, Ige; Tampubolon, A. M.; Purnama, S.; Supriatna, Adam] Yayasan Kutilang Indonesia, Sleman, Yogyakarta, Indonesia. [Ibrahim, Ima N.] Natl Inst Hlth Res & Dev, Ecol & Hlth Status Res & Dev Ctr, Jakarta, Indonesia. RP Blair, PJ (reprint author), USN, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. EM Patrick.blair@med.navy.mil FU U.S. Department of Defenses' Global Emerging Infection Systems (DoD-GEIS); United States Agency for International Development (USAID); Centers for Disease Control and Prevention FX The authors are grateful for the assistance of the field staff at the Indonesian Ornithologists' Union, Yayasan Kutilang Indonesia, PILI- NGO Movement and the Animal Rescue Centers' Network. We thank the laboratory staff at the National Institute of Health Research and Development and the Naval Medical Research Unit # 2 for processing and analyzing samples and Christian Hansen for statistical analysis. This work was supported by grants from the U.S. Department of Defenses' Global Emerging Infection Systems (DoD-GEIS), the United States Agency for International Development (USAID), and the Centers for Disease Control and Prevention. The views expressed in this manuscript are those of the authors and do not represent official policy of the U.S. Department of Defense or Department of the Navy. NR 37 TC 5 Z9 6 U1 1 U2 5 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD DEC PY 2009 VL 9 IS 6 BP 695 EP 702 DI 10.1089/vbz.2008.0183 PG 8 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 530GE UT WOS:000272576300018 PM 19271996 ER PT J AU Taylor, MK Mujica-Parodi, LR Potterat, EG Momen, N Ward, MDD Padilla, GA Markham, AE Evans, KE AF Taylor, Marcus K. Mujica-Parodi, Lilianne R. Potterat, Eric G. Momen, Nausheen Ward, Michael D. Dial Padilla, Genieleah A. Markham, Amanda E. Evans, Katherine E. TI Anger Expression and Stress Responses in Military Men SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE stress; survival; evasion; PTSD ID UNCONTROLLABLE STRESS; TRAUMA EXPOSURE; NEUROPEPTIDE-Y; SYMPTOMS; PERFORMANCE; CORTISOL; DISSOCIATION; ANXIETY; ASSOCIATIONS; DEPLOYMENT AB TAYLOR MK, MUJICA-PARODI LR, POTTTERAI EG, MOMEN N, DIAL WARD MD, PADILLA GA, MARKHAM AE, EVANS KE. Anger expression and stress responses in military men. Aviat Space Environ Med 2009; 80:962-7. Introduction: A better understanding of individual differences in the human stress response may enhance prevention and treatment of operational stress reactions In this study, we examined the relationships of anger experience and expression to stress indices during daily living and ill response to military survival training in 4.5 men Methods. Prior to participation in survival training, subjects completed self-report measures of perceived stress and anger. The revised Impact of Event Scale was then administered 24 h after the conclusion of training. Results: As expected, outward anger expression was positively associated with perceived stress during free living (P < 0 0125) outward anger expression, inward anger expression, and angry temperament then combined to account for 25%, of the variance in psychological impact of a stressful mock-captivity challenge Conclusion: Anger characteristics are associated with human stress endpoints, both during daily living and in response to all ecologically valid stressor These findings may assist in the prevention and treatment of operational stress reactions. C1 [Taylor, Marcus K.] USN, Aerosp Med Res Lab, Operat Stress & Resilience Program, Pensacola, FL 32508 USA. [Mujica-Parodi, Lilianne R.] SUNY Stony Brook, Dept Biomed Engn, Stony Brook, NY 11794 USA. [Potterat, Eric G.] USN, Special Warfare Ctr, San Diego, CA 92152 USA. [Momen, Nausheen; Padilla, Genieleah A.; Markham, Amanda E.; Evans, Katherine E.] USN, Dept 162, Hlth Res Ctr, San Diego, CA 92152 USA. [Ward, Michael D. Dial] Learning Site SERE W, Ctr Secur Forces, San Diego, CA USA. RP Taylor, MK (reprint author), USN, Aerosp Med Res Lab, Operat Stress & Resilience Program, 280 Fred Bauer St, Pensacola, FL 32508 USA. OI Mujica-Parodi, Lilianne/0000-0002-3752-5519 FU Office of Naval Research Stress Physiology and Force Health Protection Programs FX This study was supported by grants from the Office of Naval Research Stress Physiology and Force Health Protection Programs. All opinions expressed in this article, report, etc are those of the author(s) and do not necessarily reflect upon the official Policy of the Bureau of Medicine and Surgery, Department of the Navy, or Department of Defense. Thus research has been conducted in compliance with all applicable federal regulations governing the protection of human subjects in research. NR 35 TC 2 Z9 2 U1 1 U2 2 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD NOV PY 2009 VL 80 IS 11 BP 962 EP 967 DI 10.3357/ASEM.2536.2009 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 512RI UT WOS:000271267500007 PM 19911520 ER PT J AU Nelson, AP Parrish, DA Cambrea, LR Baldwin, LC Trivedi, NJ Mulfort, KL Farha, OK Hupp, JT AF Nelson, Andrew P. Parrish, Damon A. Cambrea, Lee R. Baldwin, Lawrence C. Trivedi, Nirupam J. Mulfort, Karen L. Farha, Omar K. Hupp, Joseph T. TI Crystal to Crystal Guest Exchange in a Mixed Ligand Metal-Organic Framework SO CRYSTAL GROWTH & DESIGN LA English DT Article ID MN2+ COORDINATION SITES; HYDROGEN STORAGE; SORPTION PROPERTIES; ADSORPTION; BINDING; SEPARATION; CATALYSIS; POLYMERS; SOLIDS; MIL-53 AB The occluded solvent in a mixed ligand metal-organic framework has been displaced by n-hexanol, chloroform, and nitrobenzene in a crystal to crystal guest exchange. The X-ray structures of the three new solvent addticts of Zn(2)NDC(2)DPNI(2) reveal the complete replacement of N',N-dimethylformamide with the new guest. Structural changes to the framework geometry in response to the size of the incoming guest are also exhibited. These new frameworks are characterized by powder X-ray diffraction, thermal gravimetric analysis coupled with infrared spectroscopy, and cross-polarization magic angle spinning NMR. C1 [Nelson, Andrew P.; Cambrea, Lee R.; Baldwin, Lawrence C.; Trivedi, Nirupam J.] USN, Air Warfare Ctr, Weap Div, China Lake, CA 93555 USA. [Parrish, Damon A.] USN, Res Lab, Washington, DC 20375 USA. [Mulfort, Karen L.; Farha, Omar K.; Hupp, Joseph T.] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA. [Mulfort, Karen L.; Farha, Omar K.; Hupp, Joseph T.] Northwestern Univ, Int Inst Nanotechnol, Evanston, IL 60208 USA. RP Nelson, AP (reprint author), USN, Air Warfare Ctr, Weap Div, China Lake, CA 93555 USA. EM andrew.p.nelson@navy.mil RI Hupp, Joseph/K-8844-2012; Farha, Omar/B-5512-2014 OI Hupp, Joseph/0000-0003-3982-9812; Farha, Omar/0000-0002-9904-9845 FU NAVAIR ILTR program; N*Star program (Naval S&T for America's Readiness); DTRA; U.S. Dept. of Energy; Northwestern NSEC FX This work was sponsored by the NAVAIR ILTR program, managed at ONR by the N*Star program (Naval S&T for America's Readiness). Work at Northwestern was sponsored by DTRA, the U.S. Dept. of Energy, and the Northwestern NSEC. NR 36 TC 24 Z9 24 U1 6 U2 34 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1528-7483 J9 CRYST GROWTH DES JI Cryst. Growth Des. PD NOV PY 2009 VL 9 IS 11 BP 4588 EP 4591 DI 10.1021/cg900735n PG 4 WC Chemistry, Multidisciplinary; Crystallography; Materials Science, Multidisciplinary SC Chemistry; Crystallography; Materials Science GA 512TG UT WOS:000271272900003 ER PT J AU Granado, NS Smith, TC Swanson, GM Harris, RB Shahar, E Smith, B Boyko, EJ Wells, TS Ryan, MAK AF Granado, Nisara S. Smith, Tyler C. Swanson, G. Marie Harris, Robin B. Shahar, Eyal Smith, Besa Boyko, Edward J. Wells, Timothy S. Ryan, Margaret A. K. CA Millennium Cohort Study Team TI Newly Reported Hypertension After Military Combat Deployment in a Large Population-Based Study SO HYPERTENSION LA English DT Article DE hypertension; incidence; stressful events; cohort studies; military personnel ID AMERICAN-HEART-ASSOCIATION; BLOOD-PRESSURE CONTROL; GULF-WAR VETERANS; BODY-MASS INDEX; MILLENNIUM COHORT; CARDIOVASCULAR-DISEASE; RESISTANCE EXERCISE; US MILITARY; ARTERIAL STIFFNESS; CIGARETTE-SMOKING AB High-stress situations, such as combat deployments, are a potential risk factor for hypertension. Although stress is postulated to increase blood pressure, the underlying role of stress on hypertension is not well established. We sought to determine the relations between combat deployment-induced stress and hypertension. The Millennium Cohort baseline questionnaire (2001-2003) was completed by 77 047 US active-duty and Reserve/National Guard members. Follow-up was completed by 55 021 responders approximate to 3 years later (2004-2006). Multivariable logistic regression was used to estimate the 3-year risk of newly reported hypertension, adjusting for general and mental health, demographics, and occupational and behavioral characteristics. After applying exclusion criteria, our analyses included 36 061 service members. Subanalyses of deployers included 8829 participants. Newly reported hypertension was identified in 6.9% of the cohort between baseline and follow-up, many of whom had deployed on military operations in support of the conflicts in Iraq and Afghanistan. After adjusting, deployers who experienced no combat exposures were less likely to report hypertension than nondeployers (odds ratio: 0.77; 95% CI: 0.67 to 0.89). Among deployers, those reporting multiple combat exposures were 1.33 times more likely to report hypertension compared with noncombat deployers (95% CI: 1.07 to 1.65). Although military deployers, in general, had a lower incidence of hypertension than nondeployers, deployment with multiple stressful combat exposures appeared to be a unique risk factor for newly reported hypertension. (Hypertension. 2009; 54: 966-973.) C1 [Granado, Nisara S.; Smith, Tyler C.; Smith, Besa] USN, Hlth Res Ctr, Dept Def Ctr Deployment Hlth Res, San Diego, CA 92106 USA. [Swanson, G. Marie] Indiana Univ, Sch Med, Dept Publ Hlth, Indianapolis, IN USA. [Harris, Robin B.; Shahar, Eyal] Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Tucson, AZ USA. [Boyko, Edward J.] Vet Affairs Puget Sound Hlth Care Syst, Seattle Epidemiol Res & Informat Ctr, Seattle, WA USA. [Smith, Tyler C.] USAF, Res Lab, Dayton, OH USA. [Ryan, Margaret A. K.] USN, Hosp Camp Pendleton, Dept Occupat Hlth, Camp Pendleton, CA USA. RP Granado, NS (reprint author), USN, Hlth Res Ctr, Dept Def Ctr Deployment Hlth Res, 140 Sylvester Rd, San Diego, CA 92106 USA. EM nisara.granado@med.navy.mil FU Military Operational Medicine Research Program; United States Army Medical Research and Material Command FX The Millennium Cohort Study is funded through the Military Operational Medicine Research Program, United States Army Medical Research and Material Command (Fort Detrick, MD). NR 43 TC 36 Z9 37 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0194-911X J9 HYPERTENSION JI Hypertension PD NOV PY 2009 VL 54 IS 5 BP 966 EP 973 DI 10.1161/HYPERTENSIONAHA.109.132555 PG 8 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 509CW UT WOS:000270992100010 PM 19752293 ER PT J AU Lee, EU Glinka, G Vasudevan, AK Iyyer, N Phan, ND AF Lee, E. U. Glinka, G. Vasudevan, A. K. Iyyer, N. Phan, N. D. TI Fatigue of 7075-T651 aluminum alloy under constant and variable amplitude loadings SO INTERNATIONAL JOURNAL OF FATIGUE LA English DT Article; Proceedings Paper CT 7th International Conference on Fatigue Damage in Structural Materials CY SEP 14-19, 2008 CL Hyannis, MA DE Fatigue crack growth; Constant and variable amplitude loadings; Stress ratio; Frequency; Load spectrum ID CRACK-GROWTH BEHAVIOR; STRESS INTENSITIES; CORROSION FATIGUE; ENVIRONMENT; MECHANISMS; STEELS; DAMAGE; PROPAGATION; TI-6AL-4V; VACUUM AB The fatigue crack growth (FCG) behavior of 7075-T651 aluminum alloy was studied under constant and variable amplitude loadings in vacuum, air and 1% NaCl solution. In the study of constant amplitude loading fatigue, the stress ratios were 0.1 and 0.85 and the loading frequency was 10 Hz. In the study of variable amplitude loading fatigue, the load spectrums were tension type and tension-compression type, and the average loading frequency was about 5 Hz. The results of FCG tests, under constant and variable amplitude loadings, validated the unified two parameter driving force model, accounting for the residual stress and stress ratio effects on fatigue crack growth. Published by Elsevier Ltd. C1 [Lee, E. U.; Phan, N. D.] USN, Air Warfare Ctr, Div Aircraft, Patuxent River, MD 20670 USA. [Glinka, G.] Univ Waterloo, Waterloo, ON N2L 3G1, Canada. [Vasudevan, A. K.] Off Naval Res, Arlington, VA 22203 USA. [Iyyer, N.] Tech Data Anal Inc, Falls Church, VA USA. RP Lee, EU (reprint author), USN, Air Warfare Ctr, Div Aircraft, Patuxent River, MD 20670 USA. EM eun.lee@navy.mil NR 44 TC 21 Z9 22 U1 0 U2 9 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0142-1123 J9 INT J FATIGUE JI Int. J. Fatigue PD NOV-DEC PY 2009 VL 31 IS 11-12 BP 1858 EP 1864 DI 10.1016/j.ijfatigue.2008.11.013 PG 7 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 500RP UT WOS:000270322400028 ER PT J AU Lee, EU Vasudevan, AK Glinka, G AF Lee, E. U. Vasudevan, A. K. Glinka, G. TI Environmental effects on low cycle fatigue of 2024-T351 and 7075-T651 aluminum alloys SO INTERNATIONAL JOURNAL OF FATIGUE LA English DT Article; Proceedings Paper CT 7th International Conference on Fatigue Damage in Structural Materials CY SEP 14-19, 2008 CL Hyannis, MA DE Low cycle fatigue; Environmental effect; Strain amplitude; Fractographic features ID CRACK-GROWTH; CORROSION FATIGUE; DAMAGE; STEELS; ARREST AB The environmental effects on the low cycle fatigue (LCF) behavior of 2024-T351 and 7075-T651 aluminum alloys were studied at room temperature. The specimens were subjected to identical LCF tests at strain ratio R of -1 and frequency of 5 Hz in three environments: vacuum, air and 1% NaCl solution pH 2. A separate group of specimens was pre-corroded in 1% NaCl solution and then LCF-tested in air. Their strain-life relations and cyclic stress-strain responses were investigated and compared. Furthermore, the fracture surface morphology was evaluated to find the association of LCF behavior and fractographic features under different environmental conditions. Published by Elsevier Ltd. C1 [Lee, E. U.] USN, Air Warfare Ctr, Div Aircraft, Patuxent River, MD 20670 USA. [Vasudevan, A. K.] Off Naval Res, Arlington, VA 22203 USA. [Glinka, G.] Univ Waterloo, Waterloo, ON N2L 3G1, Canada. RP Lee, EU (reprint author), USN, Air Warfare Ctr, Div Aircraft, Patuxent River, MD 20670 USA. EM enu.lee@navy.mil NR 25 TC 8 Z9 11 U1 0 U2 12 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0142-1123 J9 INT J FATIGUE JI Int. J. Fatigue PD NOV-DEC PY 2009 VL 31 IS 11-12 BP 1938 EP 1942 DI 10.1016/j.ijfatigue.2008.11.012 PG 5 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 500RP UT WOS:000270322400038 ER PT J AU Bae, YS Dubbeldam, D Nelson, A Walton, KS Hupp, JT Snurr, RQ AF Bae, Youn-Sang Dubbeldam, David Nelson, Andrew Walton, Krista S. Hupp, Joseph T. Snurr, Randall Q. TI Strategies for Characterization of Large-Pore Metal-Organic Frameworks by Combined Experimental and Computational Methods SO CHEMISTRY OF MATERIALS LA English DT Article ID HYDROGEN STORAGE; SORPTION PROPERTIES; MOLECULAR-DYNAMICS; CARBON-DIOXIDE; SURFACE-AREAS; ADSORPTION; DESIGN; SIZE; SEPARATION; METHANE AB A large-pore IRMOF-16-like material (1) was synthesized solvothermally and evacuated by two solvent removal procedures: the original chloroform (CHCl(3)) method and a new supercritical carbon dioxide (SCID) method. Using several experimental and geometric characterization tools, including thermogravimetric analysis (TGA), powder X-ray diffraction (PXRD), and pore size analysis, we propose that 1 is a mixture of noncatenated IRMOF-16 and the corresponding 2-fold interwoven structure and is partially collapsed during the evacuation, especially some of the larger pores. Adsorption measurements using several gases at 77 and 298 K showed that the new SCD evacuation is superior to the conventional CHCl(3) evacuation for increasing the adsorption kinetics as well as the adsorption capacity. This work illustrates a new strategy that combines several experimental methods, geometric calculations, and molecular simulations for the characterization of metalorganic frameworks (MOFs), especially those with large pores. This combination should be helpful for future characterization of new MOFs that possibly include some imperfections such as nonuniform catenation and partial collapse of the crystalline phase. C1 [Bae, Youn-Sang; Dubbeldam, David; Snurr, Randall Q.] Northwestern Univ, Dept Chem & Biol Engn, Evanston, IL 60208 USA. [Hupp, Joseph T.] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA. [Nelson, Andrew] USN, Air Warfare Ctr, Weap Div, China Lake, CA 93555 USA. [Walton, Krista S.] Kansas State Univ, Dept Chem Engn, Manhattan, KS 66506 USA. RP Snurr, RQ (reprint author), Northwestern Univ, Dept Chem & Biol Engn, 2145 Sheridan Rd, Evanston, IL 60208 USA. EM snurr@northwestern.edu RI Walton, Krista/E-8756-2010; Garcia-Sanchez, Almudena/B-3303-2009; Snurr, Randall/B-6699-2009; Snurr, Randall/E-4900-2011; Bae, Youn-Sang/G-8073-2012; Hupp, Joseph/K-8844-2012; Dubbeldam, David/B-6753-2014 OI Hupp, Joseph/0000-0003-3982-9812; Dubbeldam, David/0000-0002-4382-1509 FU Korea Research Foundation [KRF-2006-352-D00040]; U.S. Dept. of Energy's Office of Science [DE-FG02-01ER15244]; U.S. National Science Foundation [CTS-0507013]; TeraGrid computing facilities FX This work was supported by the Korea Research Foundation Grant funded by the Korean Goverment (MOEHRD) (KRF-2006-352-D00040), the U.S. Dept. of Energy's Office of Science (Grant No. DE-FG02-01ER15244), the U.S. National Science Foundation (CTS-0507013), and by TeraGrid computing facilities. Acknowledgment is also made to the Donors of the American Chemical Society Petroleum Research Fund for partial support of this research. NR 43 TC 42 Z9 42 U1 7 U2 44 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0897-4756 J9 CHEM MATER JI Chem. Mat. PD OCT 27 PY 2009 VL 21 IS 20 BP 4768 EP 4777 DI 10.1021/cm803218f PG 10 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 506WM UT WOS:000270807800006 ER PT J AU Feng, SM Halterman, K Overfelt, PL Bowling, D AF Feng, Simin Halterman, Klaus Overfelt, Pamela L. Bowling, Donald TI Cyclic Sommerfeld Resonances in Nanorods at Grazing Incidences SO OPTICS EXPRESS LA English DT Article ID OBLIQUE-INCIDENCE; DIELECTRIC CYLINDER; PHOTONIC CRYSTALS; SCATTERING; NANOPARTICLES; SURFACE; INDEX; MODES AB We investigate electromagnetic scattering from nanoscale wires and reveal the emergence of a family of exotic resonances for source waves close to grazing incidence. These grazing resonances have a much higher Q-bandwidth product and thus, a much higher Q factor and broader bandwidth than the pure plasmonic resonances found in metal nanowires. Furthermore, these grazing resonances are much less susceptible to material losses than surface plasmon resonances. Contrary to the process of exciting surface plasmon resonances, these grazing resonances can arise in both dielectric and metallic nanowires and appear near to the cutoff wavelength of the circular waveguide. This peculiar resonance effect originates from the excitation of long range guided surface waves through the interplay of coherently scattered continuum modes coupled with first-order azimuthal propagating modes of the cylindrical nanowire. These first-order cyclic Sommerfeld waves and associated cyclic Sommerfeld resonances revealed here opens up the possibility of an alternative scheme of enhanced fields with a better merit (higher Q-bandwidth product and lower loss) than conventional surface plasmon resonances in the nano-regime. This nanowire resonance phenomenon can be utilized in broad scientific areas, including: metamaterial designs, nanophotonic integration, nanoantennas, and nanosensors. C1 [Feng, Simin; Halterman, Klaus; Overfelt, Pamela L.; Bowling, Donald] USN, Res & Intelligence Dept, Div Phys, Air Warfare Ctr, China Lake, CA 93555 USA. RP Feng, SM (reprint author), USN, Res & Intelligence Dept, Div Phys, Air Warfare Ctr, China Lake, CA 93555 USA. EM simin.feng@navy.mil RI Halterman, Klaus/G-3826-2012; OI Halterman, Klaus/0000-0002-6355-3134 FU Office of Naval Research (ONR) FX The authors gratefully acknowledge G. A. Lindsay, Z. Sechrist, and G. Ostrom for valuable discussions and the support from the Office of Naval Research (ONR), as well as NAVAIR's ILIR program from ONR. NR 32 TC 5 Z9 5 U1 3 U2 7 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD OCT 26 PY 2009 VL 17 IS 22 BP 19823 EP 19841 DI 10.1364/OE.17.019823 PG 19 WC Optics SC Optics GA 517PS UT WOS:000271629200052 PM 19997204 ER PT J AU Gorham, ED Barrett-Connor, E Highfill-McRoy, RM Mohr, SB Garland, CF Garland, FC Ricordi, C AF Gorham, E. D. Barrett-Connor, E. Highfill-McRoy, R. M. Mohr, S. B. Garland, C. F. Garland, F. C. Ricordi, C. TI Incidence of insulin-requiring diabetes in the US military SO DIABETOLOGIA LA English DT Article DE Incidence rates; Insulin-requiring diabetes; Race; Seasonality; Sex; Vitamin D; Young adults ID VITAMIN-D; MELLITUS; TYPE-1; AMERICANS AB The aim of the study was to determine age- and race-related, and overall incidence rates of insulin-requiring diabetes in adults in the US military. Electronic records for admissions to US military and Tricare hospitals during 1990-2005 and visits to military clinics during 2000-2005 were identified using the Career History Archival Medical and Personnel System at the Naval Health Research Center, San Diego, CA, USA. Population data were obtained from the Defense Manpower Data Center and Defense Medical Epidemiology Database. In men there were 2,918 new cases of insulin-requiring diabetes in 20,427,038 person-years at ages 18-44 years (median age 28 years) for a total age-adjusted incidence rate of 17.5 per 100,000 person-years (95% CI 16.4-18.6). Incidence rates were twice as high in black men as in white men (31.5 vs 14.5 per 100,000, p < 0.001). In women there were 414 new cases in 3,285,000 person-years at ages 18-44 years (median age 27 years), for a total age-adjusted incidence rate of 13.6 per 100,000 (95% CI 12.4-14.9). Incidence rates were twice as high in black women as in white women (21.8 vs 9.7 per 100,000, p < 0.001). In a regression model, incidence of insulin-requiring diabetes peaked annually in the winter-spring season (OR 1.46, p < 0.01). Race and seasonal differences persisted in the multivariate analysis. Differences in incidence rates by race and season suggest a need for further research into possible reasons, including the possibility of a contribution from vitamin D deficiency. Cohort studies using prediagnostic serum 25-hydroxyvitamin D should be conducted to further evaluate this relationship. C1 [Gorham, E. D.; Barrett-Connor, E.; Mohr, S. B.; Garland, C. F.; Garland, F. C.] Univ Calif San Diego, Dept Family & Prevent Med, San Diego, CA 92106 USA. [Gorham, E. D.; Highfill-McRoy, R. M.; Mohr, S. B.; Garland, F. C.] Naval Hlth Res Ctr, San Diego, CA USA. [Ricordi, C.] Univ Miami, Miller Sch Med, Diabet Res Inst, Miami, FL 33136 USA. RP Gorham, ED (reprint author), Univ Calif San Diego, Dept Family & Prevent Med, 140 Sylvester Rd, San Diego, CA 92106 USA. EM edward.gorham@med.navy.mil OI Ricordi, Camillo/0000-0001-8092-7153 FU Congressional allocation to the Diabetes Research Institute; University of Miami; Miller School of Medicine in Miami, FL, USA through the Department of the Navy, Bureau of Medicine and Surgery FX This research was supported by a Congressional allocation to the Diabetes Research Institute, University of Miami, Miller School of Medicine in Miami, FL, USA, through the Department of the Navy, Bureau of Medicine and Surgery, under Work Unit No. 60126. The views expressed in this report are those of the authors and do not represent an official position of the Department of the Navy, Department of Defense or the US Government. The study has been approved for public release with unlimited distribution. The authors express their gratitude to: R. Guerin, Director, Tricare Health Programs Analysis and Evaluation Branch; S. Jenkins of the Tricare Management Activity Privacy Office; the Tricare Chief Information Officer and the staff of the Tricare Executive Information and Decision Support System. We also thank our Naval Health Research Center colleague E. E. K. Gunderson, who brought together the system of medical databases that were used to perform this study, M. Miller and T. Nedellec for maintaining the data sets that were used to perform the study, and S. Hilton for consultation on SPSS programming methods. Thanks are also extended to D. Washington of Tricare and Axion, who helped the authors obtain access to Tricare medical data, to M. Dove, V. Lauter and S. Seggerman of the Management Information and Analysis Division, Defense Manpower Data Center-West, who provided data on population denominators, and to the Defense Medical Epidemiology Database of the Army, whose DMED online website provided denominator data for some analyses. We also thank A. A. Burgi ( Naval Health Research Center), who read and commented on the manuscript. NR 12 TC 12 Z9 12 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0012-186X J9 DIABETOLOGIA JI Diabetologia PD OCT PY 2009 VL 52 IS 10 BP 2087 EP 2091 DI 10.1007/s00125-009-1449-x PG 5 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 494VT UT WOS:000269848100014 PM 19629431 ER PT J AU Flynn, MJ Sarkani, S Mazzuchi, TA AF Flynn, Michael J. Sarkani, Shahram Mazzuchi, Thomas A. TI Regression Analysis of Automatic Measurement Systems SO IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT LA English DT Article; Proceedings Paper CT 43rd Annual IEEE AUTOTESTCON Conference CY SEP 08-11, 2008 CL Salt Lake City, UT SP IEEE Aerosp & Elect Syst Soc DE Automatic test equipment; avionics; consolidated automated support system (CASS); reconfigurable-transportable consolidated automated support system (RTCASS); test program sets AB In this paper, regression analysis is presented to analyze the comparative performance capability between two functionally equivalent but technologically different automatic measurement systems for acceptance testing of a unit under test (UUT). Since the pass/fail criteria of a UUT are contingent upon repeatable and reproducible accurate measurements, a methodology is presented to examine if there is a statistically significant difference between two functionally equivalent automatic measurement systems. The purpose of which is to reduce the technical risk of transportability issues that occur when a UUT is in transition from the legacy measurement system to an emerging measurement system. C1 [Flynn, Michael J.] Naval Air Warfare Ctr, Div Aircraft, Patuxent River, MD 20670 USA. [Sarkani, Shahram; Mazzuchi, Thomas A.] George Washington Univ, Washington, DC 20052 USA. RP Flynn, MJ (reprint author), Naval Air Warfare Ctr, Div Aircraft, Patuxent River, MD 20670 USA. NR 22 TC 4 Z9 4 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-9456 J9 IEEE T INSTRUM MEAS JI IEEE Trans. Instrum. Meas. PD OCT PY 2009 VL 58 IS 10 BP 3373 EP 3379 DI 10.1109/TIM.2009.2025467 PG 7 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 493XP UT WOS:000269772900003 ER PT J AU Smith, TC AF Smith, Tyler C. CA Millennium Cohort Study Team TI The US Department of Defense Millennium Cohort Study: Career Span and Beyond Longitudinal Follow-Up SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; MILITARY SERVICE MEMBERS; MENTAL-HEALTH PROBLEMS; SMALLPOX VACCINATION; ANTHRAX VACCINATION; CIGARETTE-SMOKING; COMBAT DEPLOYMENT; VETERANS HEALTH; BIRTH-DEFECTS; PRIME-MD AB Objective: To describe current and future career-span health research in the US Department of Defense Millennium Cohort Study. Methods: Collaborating with all military service branches and the Department of Veterans Affairs, the Millennium Cohort Study launched in 2001, before September 11 and the start of deployments in Afghanistan and Iraq, to conduct coordinated strategic research to determine an effects of military occupational and deployment-related exposures, on long-term health. Results: More than 150,000 consenting members represent demographic, occupational, military, and health characteristics of the US military. More than 70% of the first two panels have submitted follow-up questionnaires and >50% have deployed since 2001. Conclusions: Prospective cohort data have identified subgroups of military populations at higher risk or more resilient to decrements in mental and physical health. Continued career span and beyond follow-up will answer long-term health questions related to military service. (J Occup Environ Med. 2009;51:1193-1201) C1 [Smith, Tyler C.; Millennium Cohort Study Team] USN, Hlth Res Ctr, Dept Def, Ctr Deployment Hlth Res, San Diego, CA 92106 USA. RP Smith, TC (reprint author), USN, Hlth Res Ctr, Dept Def, Ctr Deployment Hlth Res, 140 Sylvester Rd, San Diego, CA 92106 USA. EM tyler.c.smith@med.navy.mil NR 51 TC 36 Z9 37 U1 2 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD OCT PY 2009 VL 51 IS 10 BP 1193 EP 1201 DI 10.1097/JOM.0b013e3181b73146 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 506AZ UT WOS:000270746100011 PM 19786902 ER PT J AU Metzgar, D Skochko, G Gibbins, C Hudson, N Lott, L Jones, MS AF Metzgar, David Skochko, Greg Gibbins, Carl Hudson, Nolan Lott, Lisa Jones, Morris S. TI Evaluation and Validation of a Real-Time PCR Assay for Detection and Quantitation of Human Adenovirus 14 from Clinical Samples SO PLOS ONE LA English DT Article AB In 2007, the Centers for Disease Control and Prevention (CDC) reported that Human adenovirus type 14 (HAdV-14) infected 106 military personnel and was responsible for the death of one U. S. soldier at Lackland Air Force Base in Texas. Identification of the responsible adenovirus, which had not previously been seen in North America and for which rapid diagnostic tools were unavailable, required retrospective analysis at reference laboratories. Initial quarantine measures were also reliant on relatively slow traditional PCR analysis at other locations. To address this problem, we developed a real-time PCR assay that detects a 225 base pair sequence in the HAdV-14a hexon gene. Fifty-one oropharyngeal swab specimens from the Naval Health Research Center, San Diego, CA and Advanced Diagnostic Laboratory, Lackland AFB, TX were used to validate the new assay. The described assay detected eight of eight and 19 of 19 confirmed HAdV-14a clinical isolates in two separate cohorts from respiratory disease outbreaks. The real-time PCR assay had a wide dynamic range, detecting from 10 2 to 10 7 copies of genomic DNA per reaction. The assay did not cross-react with other adenoviruses, influenza, respiratory syncytial virus, or common respiratory tract bacteria. The described assay is easy to use, sensitive and specific for HAdV-14a in clinical throat swab specimens, and very rapid since turnaround time is less than four hours to obtain an answer. RP Metzgar, D (reprint author), Naval Hlth Res Ctr, Dept Resp Dis Res, San Diego, CA USA. EM drmorrisj@yahoo.com RI Valle, Ruben/A-7512-2013 NR 22 TC 13 Z9 13 U1 1 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD SEP 17 PY 2009 VL 4 IS 9 AR e7081 DI 10.1371/journal.pone.0007081 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 496KG UT WOS:000269970200011 PM 19759905 ER PT J AU Metzgar, D Baynes, D Hansen, CJ McDonough, EA Cabrera, DR Ellorin, MM Blair, PJ Russell, KL Faix, DJ AF Metzgar, David Baynes, Darcie Hansen, Christian J. McDonough, Erin A. Cabrera, Daisy R. Ellorin, Melody M. Blair, Patrick J. Russell, Kevin L. Faix, Dennis J. TI Inference of Antibiotic Resistance and Virulence among Diverse Group A Streptococcus Strains Using emm Sequencing and Multilocus Genotyping Methods SO PLOS ONE LA English DT Article AB Background: Group A Streptococcus pyogenes ( GAS) exhibits a high degree of clinically relevant phenotypic diversity. Strains vary widely in terms of antibiotic resistance (AbR), clinical severity, and transmission rate. Currently, strain identification is achieved by emm typing ( direct sequencing of the genomic segment coding for the antigenic portion of the M protein) or by multilocus genotyping methods. Phenotype analysis, including critical AbR typing, is generally achieved by much slower and more laborious direct culture-based methods. Methodology/Principal Findings: We compare genotype identification ( by emm typing and PCR/ESI-MS) with directly measured phenotypes ( AbR and outbreak associations) for 802 clinical isolates of GAS collected from symptomatic patients over a period of 6 years at 10 military facilities in the United States. All independent strain characterization methods are highly correlated. This shows that recombination, horizontal transfer, and other forms of reassortment are rare in GAS insofar as housekeeping genes, primary virulence and antibiotic resistance determinants, and the emm gene are concerned. Therefore, genotyping methods offer an efficient way to predict emm type and the associated AbR and virulence phenotypes. Conclusions/Significance: The data presented here, combined with much historical data, suggest that emm typing assays and faster molecular methods that infer emm type from genomic signatures could be used to efficiently infer critical phenotypic characteristics based on robust genotype: phenotype correlations. This, in turn, would enable faster and better-targeted responses during identified outbreaks of constitutively resistant or particularly virulent emm types. RP Metzgar, D (reprint author), Naval Hlth Res Ctr, Dept Resp Dis Res, San Diego, CA USA. EM david.metzgar@med.navy.mil RI Valle, Ruben/A-7512-2013 NR 24 TC 3 Z9 3 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD SEP 4 PY 2009 VL 4 IS 9 AR e6897 DI 10.1371/journal.pone.0006897 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 491ZF UT WOS:000269622100003 PM 19730733 ER PT J AU Rowe, MA Kelly, A Horne, C Lane, S Campbell, J Lehman, B Phipps, C Keller, M Benito, AP AF Rowe, Meredeth A. Kelly, Annette Horne, Claydell Lane, Steve Campbell, Judy Lehman, Brandy Phipps, Chad Keller, Meredith Benito, Andrea Pe TI Reducing dangerous nighttime events in persons with dementia by using a nighttime monitoring system SO ALZHEIMERS & DEMENTIA LA English DT Article DE Alzheimer's disease; Dementia; Nighttime activity; Sleep; Caregivers; Injury; Technology; Monitoring system ID ALZHEIMERS-DISEASE; INSTITUTIONALIZATION; PREDICTORS; CAREGIVERS; PLACEMENT; PEOPLE; HOME AB Background: Nighttime activity, a common occurrence in persons with dementia, increases the risk for injury and unattended home exits and impairs the sleep patterns of caregivers. Technology is needed that will alert caregivers of nighttime activity in persons with dementia to help prevent injuries and unattended exits. Methods: As part of a product development grant, a controlled pilot study was conducted to test the effectiveness of a new night monitoring system designed for informal caregivers to use in the home. Data from 53 subjects were collected at nine points in time during a 12-month period regarding injuries and unattended home exits that occurred while the caregiver slept. Nighttime activity frequently resulted in nursing home placement. Results: The night monitoring system proved a reliable adjunct to assist caregivers in managing nighttime activity. A total of nine events (injuries or unattended home exits) occurred during the study, with 6 events occurring in the control group. With intent-to-treat analysis, there was no difference between the groups. However, in a secondary analysis that was based on use of the intervention, experimental subjects were 85% less likely to sustain an event than control subjects. Conclusions: When nighttime activity occurred, it resulted in severe injuries sometimes associated with subsequent nursing home placement. The night monitoring system represents a new technology that caregivers can use to assist them in preventing nighttime injuries and unattended home exits in care recipients with dementia. (C) 2009 The Alzheimer's Association. All rights reserved. C1 [Rowe, Meredeth A.; Horne, Claydell; Campbell, Judy; Benito, Andrea Pe] Univ Florida, Coll Nursing, Gainesville, FL 32611 USA. [Kelly, Annette] Florida So Coll, Lakeland, FL USA. [Lane, Steve] Amron Corp, Mclean, VA USA. [Lehman, Brandy] Univ S Florida, Tampa, FL USA. [Phipps, Chad] San Diego Naval Hosp, San Diego, CA USA. [Keller, Meredith] Natl Naval Med Ctr, Bethesda, MD USA. RP Rowe, MA (reprint author), Univ Florida, Coll Nursing, Gainesville, FL 32611 USA. EM mrowe@ufl.edu FU NINR NIH HHS [R42 NR004952-02A2, R42 NR004952-03, R42 NR004952, 2R42NR004952-02A2]; PHS HHS [1R41N004952-01A1] NR 27 TC 19 Z9 19 U1 3 U2 9 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1552-5260 J9 ALZHEIMERS DEMENT JI Alzheimers. Dement. PD SEP PY 2009 VL 5 IS 5 BP 419 EP 426 DI 10.1016/j.jalz.2008.08.005 PG 8 WC Clinical Neurology SC Neurosciences & Neurology GA 503ZL UT WOS:000270581400007 PM 19751921 ER PT J AU Jacobson, IG White, MR Smith, TC Smith, B Wells, TS Gackstetter, GD Boyko, EJ AF Jacobson, Isabel G. White, Martin R. Smith, Tyler C. Smith, Besa Wells, Timothy S. Gackstetter, Gary D. Boyko, Edward J. CA Millennium Cohort Study Team TI Self-Reported Health Symptoms and Conditions Among Complementary and Alternative Medicine Users in a Large Military Cohort SO ANNALS OF EPIDEMIOLOGY LA English DT Article DE Cohort Studies; Complementary Therapies; Signs and Symptoms ID UNITED-STATES; MILLENNIUM COHORT; PRIMARY-CARE; PRIME-MD; PREVALENCE; UTILITY; SERVICES AB PURPOSE: To describe medical symptom and condition reporting in relation to complementary and alternative medicine (CAM) use among members of the US military. METHODS: CAM was defined as health treatments not widely taught at US medical schools or typically available at US hospitals. By using data from the Millennium Cohort Study, we included participants who completed a survey from 2004 to 2006 (n = 86,131) as part of this cross-sectional analysis in which we sought to identify demographic characteristics and types of health-related symptoms and conditions associated with CAM use. Chi-square tests were used to compare health assessed by self-reported symptoms and conditions among those not reporting CAM use with those reporting practitioner-assisted or self-administered CAM. RESULTS: Of 86,131 participants, 30% reported using at least one practitioner-assisted CAM therapy, 27% reported using at least one self-administered CAM therapy, whereas 59% did not report using any CAM therapy. Both women and men who used CAM reported a greater proportion of specific health conditions and health-related symptoms compared with those not reporting CAM use (p < 0.05). CONCLUSIONS: These findings illustrate that a relatively young adult occupational cohort of military personnel using CAM therapies also report multiple comorbidities which may indicate chronic illness management and poorer overall health. Ann Epidemiol 2009;19:613-622. (C) Published by Elsevier Inc. C1 [Jacobson, Isabel G.; White, Martin R.; Smith, Tyler C.; Smith, Besa] USN, Hlth Res Ctr, US Dept Def, Ctr Deployment Hlth Res, San Diego, CA 92106 USA. [Wells, Timothy S.] USAF, Res Lab, Wright Patterson AFB, OH 45433 USA. [Boyko, Edward J.] Vet Affairs Puget Sound Hlth Care Syst, Seattle Epidetniol Res & Informat Ctr, Seattle, WA USA. [Gackstetter, Gary D.] Analyt Serv Inc, ANSER, Arlington, VA USA. RP Jacobson, IG (reprint author), USN, Hlth Res Ctr, US Dept Def, Ctr Deployment Hlth Res, Dept 164,140 Sylvester Rd, San Diego, CA 92106 USA. EM isabel.jacobson@med.navy.mil NR 30 TC 18 Z9 18 U1 3 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1047-2797 J9 ANN EPIDEMIOL JI Ann. Epidemiol. PD SEP PY 2009 VL 19 IS 9 BP 613 EP 622 DI 10.1016/j.annepidem.2009.05.001 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 488ES UT WOS:000269332600002 PM 19596206 ER PT J AU Dikici, B Dean, SW Pantoya, ML Levitas, VI Jouet, RJ AF Dikici, Birce Dean, Steven W. Pantoya, Michelle L. Levitas, Valery I. Jouet, R. Jason TI Influence of Aluminum Passivation on the Reaction Mechanism: Flame Propagation Studies SO ENERGY & FUELS LA English DT Article ID POLYMORPHIC PHASE-TRANSFORMATIONS; NANOPARTICLE OXIDATION; IGNITION; NANOCOMPOSITES; NANOPOWDERS; THERMITES AB Currently, two main known mechanisms of aluminum (Al) nanoparticle reaction are discussed in the literature, namely these based on diffusion through an oxide shell melt dispersion. The two mechanisms lead to opposite predictions in nanoparticle design. This diffusion mechanism suggests that the reduction or complete elimination of the oxide shell will increase Al reactivity, whereas the melt-dispersion mechanism suggests an increase in initial oxide thickness up to an optimal value. The goal of this study is to perform critical experiments in a confined flame tube apparatus to compare these two predictions. Specifically, the flame propagation rates of perfluoroalkyl carboxylic acid (C13F27COOH). treated Al nanoparticles with and without an alumina shell were measured. Results show that when there is no alumina passivation shell encasing the Al core, the flame rate decreases by a factor of 22-95 and peak pressure decease by 3 orders of manitude, in comparision with the A1 particles with an oxide shell. These results imply that the melt-dispersion reaction mechanism is responisble for high flame propagation rates observed in these confined tube experiments. C1 [Dikici, Birce; Dean, Steven W.; Pantoya, Michelle L.; Levitas, Valery I.] Texas Tech Univ, Dept Mech Engn, Lubbock, TX 79409 USA. [Levitas, Valery I.] Iowa State Univ, Dept Mech Engn, Ames, IA 50011 USA. [Levitas, Valery I.] Iowa State Univ, Dept Aerosp Engn, Ames, IA 50011 USA. [Levitas, Valery I.] Iowa State Univ, Dept Mat Sci & Engn, Ames, IA 50011 USA. [Jouet, R. Jason] Naval Surface Warfare Ctr, Indian Head Div, Res & Technol Dept, Indian Head, MD 20640 USA. RP Pantoya, ML (reprint author), Texas Tech Univ, Dept Mech Engn, Lubbock, TX 79409 USA. EM michelle.pantoya@ttu.edu FU Army Research Office [W911NF-04-1-0217]; Office of Naval Research [N000140810104]; National Science Foundation [CBET-0755236] FX The authors gratefully acknowledge support from the Army Research Office contract W911NF-04-1-0217 (program director Dr. Ralph Anthenien), Office of Naval Research contract N000140810104 (program director Dr. Clifford Bedford), and National Science Foundation grant CBET-0755236 (program director Dr. Phillip Westmereland. NR 20 TC 27 Z9 27 U1 0 U2 23 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0887-0624 J9 ENERG FUEL JI Energy Fuels PD SEP PY 2009 VL 23 BP 4231 EP 4235 DI 10.1021/ef801116x PG 5 WC Energy & Fuels; Engineering, Chemical SC Energy & Fuels; Engineering GA 505EG UT WOS:000270671500004 ER PT J AU MacGregor, AJ Corson, KS Larson, GE Shaffer, RA Dougherty, AL Galarneau, MR Raman, R Baker, DG Lindsay, SP Golomb, BA AF MacGregor, Andrew J. Corson, Karen S. Larson, Gerald E. Shaffer, Richard A. Dougherty, Amber L. Galarneau, Michael R. Raman, Rema Baker, Dewleen G. Lindsay, Suzanne P. Golomb, Beatrice A. TI Injury-specific predictors of posttraumatic stress disorder SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED LA English DT Article DE Combat injury; Military; Posttraumatic stress disorder; Operation Iraqi Freedom ID MOTOR-VEHICLE ACCIDENT; COMBAT TRAUMA REGISTRY; ROAD TRAFFIC ACCIDENT; HEART-RATE; FOLLOW-UP; PSYCHOPHYSIOLOGICAL AROUSAL; PSYCHIATRIC-DISORDERS; SEVERITY SCORE; OKLAHOMA-CITY; RISK-FACTORS AB Objective: Posttraumatic stress disorder (PTSD) is an important source of morbidity in military personnel, but its relationship with characteristics of battle injury has not been well defined. The aim of this study was to characterise the relationship between injury-related factors and PTSD among a population of battle injuries. Patients and methods: A total of 831 American military personnel injured during combat between September 2004 and February 2005 composed the study population. Patients were followed through November 2006 for diagnosis of PTSD (ICD-9 309.81) or any mental health outcome (ICD-9 290-319). Results: During the follow-up period, 31.3% of patients received any type of mental health diagnosis and 17.0% received a PTSD diagnosis. Compared with minor injuries those with moderate (odds ratio [OR], 2.37; 95% confidence interval [Cl], 1.61-3.48), serious (OR, 4.07; 95% Cl, 2.55-6.50), and severe (OR, 5.22; 95% Cl, 2.74-9.96) injuries were at greater risk of being diagnosed with any mental health outcome. Similar results were found for serious (OR, 3.03; 95% Cl, 1.81-5.08) and severe (OR, 3.21; 95% Cl, 1.62-6.33) injuries with PTSD diagnosis. Those with gunshot wounds were at greater risk of any mental health diagnosis, but not PTSD, in comparison with other mechanisms of injury (OR 2.07; 95% Cl, 1.35, 3.19). Diastolic blood pressure measured postinjury was associated with any mental health outcome, and the effect was modified by injury severity. Conclusions: Injury severity was a significant predictor of any mental health diagnosis and PTSD diagnosis. Gunshot wounds and diastolic blood pressure were significant predictors of any mental health diagnosis, but not PTSD. Further studies are needed to replicate these results and elucidate potential mechanisms for these associations. (C) 2009 Elsevier Ltd. All rights reserved. C1 [MacGregor, Andrew J.; Dougherty, Amber L.; Galarneau, Michael R.] USN, Hlth Res Ctr, Dept Med Modeling Simulat & Mission Support, San Diego, CA 92106 USA. [Shaffer, Richard A.] USN, Hlth Res Ctr, DoD HIV AIDS Prevent Program, San Diego, CA 92106 USA. [Dougherty, Amber L.] Sci Applicat Int Corp, Hlth Res & Appl Technol Div, San Diego, CA 92121 USA. [Raman, Rema] Univ Calif San Diego, Dept Family & Prevent Med, San Diego, CA 92103 USA. [Baker, Dewleen G.] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA. [Baker, Dewleen G.] VA San Diego Healthcare Syst, Psychiat Serv, San Diego, CA USA. [Lindsay, Suzanne P.] San Diego State Univ, Grad Sch Publ Hlth, San Diego, CA 92182 USA. [Golomb, Beatrice A.] Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA. RP Dougherty, AL (reprint author), USN, Hlth Res Ctr, Dept Med Modeling Simulat & Mission Support, 140 Sylvester Rd, San Diego, CA 92106 USA. EM amber.dougherty@med.navy.mil FU U.S. Navy Bureau of Medicine and Surgery; Psychological Health and Traumatic Brain Injury Program, Washington, DC FX This work was supported by The U.S. Navy Bureau of Medicine and Surgery, Psychological Health and Traumatic Brain Injury Program, Washington, DC under work unit 60332. The views and opinions expressed herein are those of the authors and do not necessarily reflect the official policy or position of the United States Department of the Navy, Department of Defense, nor the U.S. Government. This research has been conducted in compliance with all applicable federal regulations governing the protection of human subjects in research (Protocol NHRC.2007.0004). NR 58 TC 20 Z9 20 U1 5 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0020-1383 J9 INJURY JI Injury-Int. J. Care Inj. PD SEP PY 2009 VL 40 IS 9 BP 1004 EP 1010 DI 10.1016/j.injury.2009.04.006 PG 7 WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery GA 487KE UT WOS:000269271500019 PM 19524912 ER PT J AU Allan, SA Kline, DL Walker, T AF Allan, Sandra A. Kline, Daniel L. Walker, Todd TI ENVIRONMENTAL FACTORS AFFECTING EFFICACY OF BIFENTHRIN-TREATED VEGETATION FOR MOSQUITO CONTROL SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE bifenthrin; mosquito control; Aedes aegypti; leaves; wax myrtle; azalea ID ADULT AEDES-ALBOPICTUS; SCREENED FIELD CAGES; CULEX-QUINQUEFASCIATUS; RESIDUAL EFFECTIVENESS; FEMALE MOSQUITOS; COTTON PLANTS; PERMETHRIN; CULICIDAE; DIPTERA; FOLIAGE AB The use of pesticide-treated vegetation as a barrier for control of nuisance and disease-bearing mosquitoes has become an option for mosquito management for home owners and public health and mosquito control professionals. Potted wax myrtle and azalea plants were treated with bifenthrin (0.79% AI) at maximum label rate using backpack and electrostatic sprayers and exposed to various treatments that could affect the residual degradation of the applied pesticides. Treatments included leaf aspect, simulated rainfall, shade, and natural sun exposure with the residual effectiveness of leaves examined in tarsal contact Petri dish assays using laboratory-reared Aedes aegypti. There was no significant difference in efficacy between the adaxial (top) or abaxial (bottom) surfaces of electrostatically or backpack-treated leaves. Significant differences existed between application method, plant species, and exposure with most significant effects between weeks 1 and 4. Simulated heavy rainfalls applied 3 times weekly reduced knockdown by leaves treated with electrostatic and backpack methods with reductions seen as soon as 1 wk after treatment. Reductions were seen with both wax myrtle and azalea leaves and after 1, 4, and 24 h contact of mosquitoes to leaves. Placement of plants with full exposure to sunlight also significantly reduced efficacy compared to plants placed in the shade. Differences were observed most often for 4 and 24 h knockdown counts, and significant decreases were seen from week 4 onwards. Clearly factors such as rain and exposure to sun impact degradation of efficacy of bifenthrin-treated vegetation in the field. Degradation of bifenthrin efficacy was slowest in sites protected from rain and sun, which coincide with preferred resting site locations for many mosquito species. C1 [Allan, Sandra A.; Kline, Daniel L.] ARS, USDA, Gainesville, FL 32608 USA. [Walker, Todd] USN, Entomol Ctr Excellence, Naval Air Stn, Jacksonville, FL 32212 USA. RP Allan, SA (reprint author), ARS, USDA, 1600 SW 23rd Dr, Gainesville, FL 32608 USA. FU Deployed War-fighter Protection Research Program; US Department of Defense through the Armed Forces Pest Management Board; United States Department of Agriculture or the Agricultural Research Service FX We thank J. McClurg and E. Vrzal for assistance with assays, J. Urban for assistance with plant treatment, and V. L. Smith and C. A. Robinson from the Naval Entomology Center of Excellence, Naval Air Station, Jacksonville, for application of pesticides to the plants. This study was supported by a Deployed War-fighter Protection Research Program Grant funded by the US Department of Defense through the Armed Forces Pest Management Board. The use of trade, firm, or corporation names in this publication is for the information and convenience of the reader. Such use does not constitute an official endorsement or approval by the United States Department of Agriculture or the Agricultural Research Service of any product or service to the exclusion of others that may be suitable. NR 38 TC 11 Z9 11 U1 2 U2 9 PU AMER MOSQUITO CONTROL ASSOC PI MOUNT LAUREL PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA SN 8756-971X EI 1943-6270 J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD SEP PY 2009 VL 25 IS 3 BP 338 EP 346 DI 10.2987/09-5854.1 PG 9 WC Entomology SC Entomology GA 504EN UT WOS:000270598300017 PM 19852225 ER PT J AU Halterman, K Valls, OT AF Halterman, Klaus Valls, Oriol T. TI Emergence of triplet correlations in superconductor/half-metallic nanojunctions with spin-active interfaces SO PHYSICAL REVIEW B LA English DT Article ID FERROMAGNET STRUCTURES AB We study triplet pairing correlations induced in an SFS trilayer (where F is a ferromagnet and S an ordinary s-wave superconductor) by spin-flip scattering at the interfaces, via the derivation and self-consistent solution of the appropriate Bogoliubov-de Gennes equations in the clean limit. We find that the spin-flip scattering generates m = +/- 1 triplet correlations, odd in time and study the general spatial behavior of these and of m = 0 correlations as a function of position and of spin-flip strength, H(spin), concentrating on the case where the ferromagnet is half-metallic. For certain values of H(spin), the triplet correlations pervade the magnetic layer and can penetrate deeply into the superconductor. The behavior we find depends very strongly on whether the singlet order parameter is in the 0 or pi state, which must in turn be determined self-consistently. We also present results for the density of states (DOS) and for the local magnetization, which, due to spin-flip processes, is not in general aligned with the magnetization of the half-metal, and near the interfaces, rotates as a function of position and H(spin). The average DOS in both F and S is shown to exhibit various subgap bound states positioned at energies that depend strongly on the particular junction state and the spin-flip scattering strength. C1 [Halterman, Klaus] USN, Res & Intelligence Dept, Div Phys, Air Warfare Ctr, China Lake, CA 93555 USA. [Valls, Oriol T.] Univ Minnesota, Sch Phys & Astron, Minneapolis, MN 55455 USA. [Valls, Oriol T.] Univ Minnesota, Minnesota Supercomp Inst, Minneapolis, MN 55455 USA. RP Halterman, K (reprint author), USN, Res & Intelligence Dept, Div Phys, Air Warfare Ctr, China Lake, CA 93555 USA. EM klaus.halterman@navy.mil; otvalls@umn.edu RI Halterman, Klaus/G-3826-2012; OI Halterman, Klaus/0000-0002-6355-3134 FU DoD High Performance Computing Modernization Program (HPCMP); ONR FX This project was supported in part by a grant of super-computer resources provided by the DoD High Performance Computing Modernization Program (HPCMP) and NA-VAIR's ILIR program sponsored by ONR. We thank I. Krivorotov for useful discussions. NR 33 TC 22 Z9 23 U1 1 U2 4 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD SEP PY 2009 VL 80 IS 10 AR 104502 DI 10.1103/PhysRevB.80.104502 PG 13 WC Physics, Condensed Matter SC Physics GA 501LJ UT WOS:000270383100085 ER PT J AU Guenthner, AJ Cash, J Hess, DM AF Guenthner, Andrew J. Cash, Jessica Hess, David M. TI POLY 603-Silicone RTV composites with enhanced thermal conductivity for mold-making applications SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Guenthner, Andrew J.; Cash, Jessica; Hess, David M.] USN, Air Warfare Ctr, Weap Div, China Lake, CA 93555 USA. EM andrew.guenthner@navy.mil; jessica.cash@navy.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 603-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HY UT WOS:000207861906489 ER PT J AU Nelson, AP Cambrea, LR Trivedi, NJ AF Nelson, Andrew P. Cambrea, Lee R. Trivedi, Nirupam J. TI Energetic MOFs: Trapping energetic materials within thermally stable metal-organic frameworks SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Nelson, Andrew P.; Cambrea, Lee R.; Trivedi, Nirupam J.] USN, Synth & Formulat Branch Code 474100D, Air Warfare Ctr, Weap Div, China Lake, CA 93555 USA. EM andrew.p.nelson@navy.mil; lee.cambrea@navy.mil; nirupam.trivedi@navy.mil NR 0 TC 0 Z9 0 U1 2 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 16 PY 2009 VL 238 MA 94-INOR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16HZ UT WOS:000207862000657 ER PT J AU Faix, DJ Sherman, SS Waterman, SH AF Faix, Dennis J. Sherman, Sterling S. Waterman, Steven H. TI Rapid-Test Sensitivity for Novel Swine-Origin Influenza A (H1N1) Virus in Humans SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter C1 [Faix, Dennis J.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Sherman, Sterling S.] USN, Med Ctr, San Diego, CA 92152 USA. [Waterman, Steven H.] Ctr Dis Control & Prevent, San Diego, CA USA. RP Faix, DJ (reprint author), USN, Hlth Res Ctr, San Diego, CA 92152 USA. EM dennis.faix@med.navy.mil RI Valle, Ruben/A-7512-2013 NR 4 TC 186 Z9 191 U1 0 U2 8 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD AUG 13 PY 2009 VL 361 IS 7 BP 728 EP 729 DI 10.1056/NEJMc0904264 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 482JX UT WOS:000268884100030 PM 19564634 ER PT J AU Kurti, RS Halterman, K Shori, RK Wardlaw, MJ AF Kurti, R. Steven Halterman, Klaus Shori, Ramesh K. Wardlaw, Michael J. TI Discrete Cylindrical Vector Beam Generation from an Array of Optical Fibers SO OPTICS EXPRESS LA English DT Article ID RADIALLY POLARIZED BEAMS; LASER-BEAM; COHERENT BEAM; BIREFRINGENCE; COMBINATION; AZIMUTHAL; DEVICE; PRISM; MODE AB A novel method is presented for the beam shaping of far field intensity distributions of coherently combined fiber arrays. The fibers are arranged uniformly on the perimeter of a circle, and the linearly polarized beams of equal shape are superimposed such that the far field pattern represents an effective radially polarized vector beam, or discrete cylindrical vector (DCV) beam. The DCV beam is produced by three or more beams that each individually have a varying polarization vector. The beams are appropriately distributed in the near field such that the far field intensity distribution has a central null. This result is in contrast to the situation of parallel linearly polarized beams, where the intensity peaks on axis. (C) 2009 Optical Society of America C1 [Kurti, R. Steven; Halterman, Klaus; Shori, Ramesh K.] USN, Res & Intelligence Dept, Div Phys, Air Warfare Ctr, China Lake, CA 93555 USA. [Wardlaw, Michael J.] Off Naval Res, Arlington, VA 22203 USA. RP Kurti, RS (reprint author), USN, Res & Intelligence Dept, Div Phys, Air Warfare Ctr, China Lake, CA 93555 USA. EM klaus.halterman@navy.mil RI Halterman, Klaus/G-3826-2012; OI Halterman, Klaus/0000-0002-6355-3134 FU DoD High Performance Computing Modernization Program (HPCMP); NAVAIRs ILIR program sponsored by ONR FX This project was supported in part by a grant of supercomputer resources provided by the DoD High Performance Computing Modernization Program (HPCMP) and NAVAIRs ILIR program sponsored by ONR. NR 31 TC 26 Z9 28 U1 3 U2 10 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD AUG 3 PY 2009 VL 17 IS 16 BP 13982 EP 13988 DI 10.1364/OE.17.013982 PG 7 WC Optics SC Optics GA 481WQ UT WOS:000268843700075 PM 19654806 ER PT J AU Klamo, JT AF Klamo, Joseph T. TI The application of controlled variable magnetic eddy current damping to the study of vortex-induced vibrations SO EXPERIMENTS IN FLUIDS LA English DT Article ID VERY-LOW MASS; CROSS-FLOW; OSCILLATING CYLINDER; FREQUENCY-RESPONSE; CIRCULAR-CYLINDER; FORCES; WAKE; AMPLITUDE; DYNAMICS; MODES AB A powerful variable magnetic eddy current damping system has been constructed and utilized in an experimental study of vortex-induced vibrations (VIV). This damping system allows us to impose precise values of nearly ideal viscous damping over a wide range of damping values of interest. This new damping system offers improvements over previously utilized damping methods. Unlike most studies of VIV, where the damping cannot be independently controlled, we are able to impose our system damping independent of the other system parameters. Also, because the system only requires that a thin conductive plate be attached to the oscillating system, the overall mass of the system does not increase dramatically and still allows the investigation of very low mass systems. Finally, the system can operate in a steady-state fashion, supplying a constant damping value for an extended period of time, or in a transient fashion, where the damping value is intentionally varied over time. With this damping system, we have systematically explored both steady and transient damping effects on VIV behavior and provide a brief overview of some sample results. C1 [Klamo, Joseph T.] CALTECH, Grad Aeronaut Labs, Pasadena, CA 91125 USA. RP Klamo, JT (reprint author), USN, US Dept Def, Naval Surface Warfare Ctr, Carderock Div, 9500 MacArthur Blvd, Bethesda, MD 20817 USA. EM joseph.klamo@navy.mil FU ONR [N00014-94-1-0793]; National Science Foundation FX I would like to thank Prof. Anatol Roshko who initially suggested using eddy currents as a means to generate damping. I am also very grateful to Profs. Anthony Leonard and Morteza Gharib for their insight and suggestions during this work. Finally, I would like to thank Prof. David Goodwin who helped with the estimations of magnetic field strength and the resultant damping during the design stage which allowed for the final product to meet the necessary requirements. This work was supported by ONR grant # N00014-94-1-0793 and a National Science Foundation Graduate Fellowship. NR 23 TC 1 Z9 1 U1 1 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0723-4864 J9 EXP FLUIDS JI Exp. Fluids PD AUG PY 2009 VL 47 IS 2 BP 357 EP 367 DI 10.1007/s00348-009-0664-z PG 11 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 474PW UT WOS:000268297400014 ER PT J AU Korsapati, H Babaei, A Bhargava, V Dohil, R Quin, A Mittal, RK AF Korsapati, H. Babaei, A. Bhargava, V. Dohil, R. Quin, A. Mittal, R. K. TI Dysfunction of the longitudinal muscles of the oesophagus in eosinophilic oesophagitis SO GUT LA English DT Article ID CONTRACTION; CHILDREN; PERISTALSIS; ADULTS; TRAFFICKING; EXPRESSION; ASYNCHRONY; CYTOKINES; EOTAXIN; EUS AB Background: Oesophageal motility, as measured by manometry, is normal in the majority of patients with eosinophilic oesophagitis (EO). However, manometry measures only the circular muscle function of the oesophagus. The goal of the present study was to assess circular and longitudinal muscle function during peristalsis in patients with EO. Methods: Ultrasound imaging and manometry were simultaneously acquired during swallow-induced peristalsis in patients with EO and controls to measure the longitudinal muscle and circular muscle contraction, respectively. A probe with an ultrasound transducer was positioned 2 cm and then 10 cm above the lower oesophageal sphincter and five, 5 ml water swallows were recorded before and after edrophonium. Results: There is no difference in the incidence of swallow-induced peristalsis and manometric pressures (a marker of circular muscle contraction) between controls and patients with EO. However, changes in the muscle thickness (a marker of longitudinal muscle contraction) are markedly diminished in patients with EO, at both 2 and 10 cm above the lower oesophageal sphincter. The longitudinal muscle response to edrophonium is markedly blunted in patients with EO. Normal subjects demonstrate synchrony between the circular and longitudinal muscle contraction during peristalsis that is affected by edrophonium. On the other hand, patients with EO demonstrate mild asynchrony of circular and longitudinal muscle contraction during swallow-induced contractions that is not altered by edrophonium. Conclusions: In patients with EO, there is selective dysfunction of the longitudinal muscle contraction during peristalsis. It is proposed that the longitudinal muscle dysfunction in EO may contribute to dysphagia. C1 [Dohil, R.] Univ Calif San Diego, Div Pediat, San Diego, CA 92103 USA. [Korsapati, H.; Babaei, A.; Bhargava, V.; Mittal, R. K.] San Diego VA Hosp, Div Gastroenterol, San Diego, CA USA. [Quin, A.] San Diego Naval Hosp, San Diego, CA USA. RP Mittal, RK (reprint author), Vet Adm Med Ctr, Div Gastroenterol 111D, 3350 Jolla Village Dr, San Diego, CA 92161 USA. EM rmittal@ucsd.edu FU NIH [RO-1DK060733] FX This work was supported by an NIH grant-RO-1DK060733. NR 36 TC 46 Z9 49 U1 0 U2 0 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0017-5749 J9 GUT JI Gut PD AUG PY 2009 VL 58 IS 8 BP 1056 EP 1062 DI 10.1136/gut.2008.168146 PG 7 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 469ML UT WOS:000267903400011 PM 19136515 ER PT J AU Huang, MX Theilmann, RJ Robb, A Angeles, A Nichols, S Drake, A D'Andrea, J Levy, M Holland, M Song, T Ge, S Hwang, E Yoo, K Cui, L Baker, DG Trauner, D Coimbra, R Lee, RR AF Huang, Ming-Xiong Theilmann, Rebecca J. Robb, Ashley Angeles, Annemarie Nichols, Sharon Drake, Angela D'Andrea, John Levy, Michael Holland, Martin Song, Tao Ge, Sheng Hwang, Eric Yoo, Kevin Cui, Li Baker, Dewleen G. Trauner, Doris Coimbra, Raul Lee, Roland R. TI Integrated Imaging Approach with MEG and DTI to Detect Mild Traumatic Brain Injury in Military and Civilian Patients SO JOURNAL OF NEUROTRAUMA LA English DT Article DE concussion; diffusion tensor imaging; head injury; magnetoencephalography; slow wave; traumatic brain injury ID DIFFUSE AXONAL INJURY; SPACE SEPARATION METHOD; HEAD-INJURY; DELTA WAVES; SPATIAL STATISTICS; VOXELWISE ANALYSIS; IMAGES; EEG; REGISTRATION; INTERFERENCE AB Traumatic brain injury (TBI) is a leading cause of sustained impairment in military and civilian populations. However, mild (and some moderate) TBI can be difficult to diagnose due to lack of obvious external injuries and because the injuries are often not visible on conventional acute MRI or CT. Injured brain tissues in TBI patients generate pathological low-frequency neuronal magnetic signal (delta waves 1-4 Hz) that can be measured and localized by magnetoencephalography (MEG). We hypothesize that abnormal MEG delta waves originate from gray matter neurons that experience de-afferentation due to axonal injury to the underlying white matter fiber tracts, which is manifested on diffusion tensor imaging (DTI) as reduced fractional anisotropy. The present study used a neuroimaging approach integrating findings of magnetoencephalography (MEG) and diffusion tensor imaging (DTI), evaluating their utility in diagnosing mild TBI in 10 subjects in whom conventional CT and MRI showed no visible lesions in 9. The results show: (1) the integrated approach with MEG and DTI is more sensitive than conventional CT and MRI in detecting subtle neuronal injury in mild TBI; (2) MEG slow waves in mild TBI patients originate from cortical gray matter areas that experience de-afferentation due to axonal injuries in the white matter fibers with reduced fractional anisotropy; (3) findings from the integrated imaging approach are consistent with post-concussive symptoms; (4) in some cases, abnormal MEG delta waves were observed in subjects without obvious DTI abnormality, indicating that MEG may be more sensitive than DTI in diagnosing mild TBI. C1 [Huang, Ming-Xiong] Univ Calif San Diego, Radiol Imaging Lab, Dept Radiol, San Diego, CA 92121 USA. [Nichols, Sharon; Trauner, Doris] Univ Calif San Diego, Dept Neurosci, San Diego, CA 92121 USA. [Baker, Dewleen G.] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92121 USA. [Coimbra, Raul] Univ Calif San Diego, Dept Surg, San Diego, CA 92121 USA. [Huang, Ming-Xiong; Robb, Ashley; Angeles, Annemarie; D'Andrea, John; Baker, Dewleen G.; Coimbra, Raul; Lee, Roland R.] VA San Diego Healthcare Syst, Res Serv, San Diego, CA USA. [Huang, Ming-Xiong; Robb, Ashley; Angeles, Annemarie; D'Andrea, John; Baker, Dewleen G.; Coimbra, Raul; Lee, Roland R.] VA San Diego Healthcare Syst, Serv Radiol, San Diego, CA USA. [Huang, Ming-Xiong; Robb, Ashley; Angeles, Annemarie; D'Andrea, John; Baker, Dewleen G.; Coimbra, Raul; Lee, Roland R.] VA San Diego Healthcare Syst, Rehabil Serv, San Diego, CA USA. [Huang, Ming-Xiong; Robb, Ashley; Angeles, Annemarie; D'Andrea, John; Baker, Dewleen G.; Coimbra, Raul; Lee, Roland R.] VA San Diego Healthcare Syst, Psychiat Serv, San Diego, CA USA. [Nichols, Sharon; Drake, Angela; Holland, Martin] San Diego Naval Hosp, Def & Vet Brain Injury Ctr, San Diego, CA USA. [Levy, Michael] Univ Calif San Diego, Childrens Hosp San Diego, San Diego, CA 92121 USA. [Yoo, Kevin] Palomar Neurosurg Ctr, Poway, CA USA. RP Huang, MX (reprint author), Univ Calif San Diego, Radiol Imaging Lab, Dept Radiol, 3510 Dunhill St, San Diego, CA 92121 USA. EM mxhuang@ucsd.edu FU Department of Veterans Affairs [051455]; M.-X. H [060812]; R.R.L [E4477-R] FX This work was supported in part by three merit review grants from the Department of Veterans Affairs (051455 and 060812 to M.-X. H.; E4477-R to R.R.L.). We thank Michael Kilmer, Diane Delrey, Catherine Cheung, Angelica Dilay, Susan Yoder, Richard Daugherty, and Terry Curry for their efforts with patient recruitment. We would also like to thank two anonymous reviewers' constructive suggestions that substantially strengthened the present study. NR 55 TC 91 Z9 92 U1 4 U2 9 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD AUG PY 2009 VL 26 IS 8 BP 1213 EP 1226 DI 10.1089/neu.2008.0672 PG 14 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 479AF UT WOS:000268629900005 PM 19385722 ER PT J AU Johnson, EC Armstrong, LE AF Johnson, Evan C. Armstrong, Lawrence E. TI Heat and Hydration Considerations for Junior and Collegiate Tennis Players SO STRENGTH AND CONDITIONING JOURNAL LA English DT Article DE dehydration; sodium; exertional heat cramps; thermoregulation; urine color ID MATCH PLAY; SINGLES TENNIS; PHYSIOLOGICAL PROFILE; EXERCISE PERFORMANCE; ELECTROLYTE BALANCE; VOLUNTARY DRINKING; URINARY INDEXES; FLUID; DEHYDRATION; RESPONSES AB Heat and hydration may not be the first considerations of tournament directors, coaches, and athletes, when preparing for tennis. However, health risks and performance decrements are associated with both. The demands of tennis, particularly during multiday tournaments, predispose players to increased core body temperature and large fluid losses. This combination of factors can lead to decreased performance and exertional heat illnesses such as heat cramps, heat syncope, or heat exhaustion. By identifying individual fluid and salt needs, designing a replacement plan, and reducing core body temperature during and between matches, athletes can optimize performance while minimizing risk of heat illness. C1 [Johnson, Evan C.] Naval Hlth Res Ctr, San Diego, CA USA. [Armstrong, Lawrence E.] Univ Connecticut, Human Performance Lab, Dept Kinesiol Exercise & Environm Physiol, Storrs, CT USA. RP Johnson, EC (reprint author), Naval Hlth Res Ctr, San Diego, CA USA. NR 63 TC 0 Z9 0 U1 2 U2 12 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1524-1602 J9 STRENGTH COND J JI Strength Cond. J. PD AUG PY 2009 VL 31 IS 4 BP 27 EP 34 DI 10.1519/SSC.0b013e3181aedff2 PG 8 WC Sport Sciences SC Sport Sciences GA 614PO UT WOS:000279072400003 ER PT J AU Endara, SM Ryan, MAK Sevick, CJ Conlin, AMS Macera, CA Smith, TC AF Endara, Skye M. Ryan, Margaret A. K. Sevick, Carter J. Conlin, Ava Marie S. Macera, Caroline A. Smith, Tyler C. TI Does acute maternal stress in pregnancy affect infant health outcomes? Examination of a large cohort of infants born after the terrorist attacks of September 11, 2001 SO BMC PUBLIC HEALTH LA English DT Article ID WORLD-TRADE-CENTER; NEW-YORK-CITY; LOW-BIRTH-WEIGHT; SEX-RATIO; MENTAL-HEALTH; IN-UTERO; POSTTRAUMATIC-STRESS; GROWTH RESTRICTION; PRETERM BIRTH; FETAL-GROWTH AB Background: Infants in utero during the terrorist attacks of September 11, 2001 may have been negatively affected by maternal stress. Studies to date have produced contradictory results. Methods: Data for this retrospective cohort study were obtained from the Department of Defense Birth and Infant Health Registry and included up to 164,743 infants born to active-duty military families. Infants were considered exposed if they were in utero on September 11, 2001, while the referent group included infants gestating in the same period in the preceding and following year (2000 and 2002). We investigated the association of this acute stress during pregnancy with the infant health outcomes of male: female sex ratio, birth defects, preterm birth, and growth deficiencies in utero and in infancy. Results: No difference in sex ratio was observed between infants in utero in the first trimester of pregnancy on September 11, 2001 and infants in the referent population. Examination of the relationship between first-trimester exposure and birth defects also revealed no significant associations. In adjusted multivariable models, neither preterm birth nor growth deficiencies were significantly associated with the maternal exposure to the stress of September 11 during pregnancy. Conclusion: The findings from this large population-based study suggest that women who were pregnant during the terrorist attacks of September 11, 2001 had no increased risk of adverse infant health outcomes. C1 [Endara, Skye M.; Sevick, Carter J.; Conlin, Ava Marie S.; Macera, Caroline A.; Smith, Tyler C.] USN, Hlth Res Ctr, US Dept Def, Ctr Deployment Hlth Res, San Diego, CA 92152 USA. [Ryan, Margaret A. K.] USN, Hosp Camp Pendleton, Camp Pendleton, CA USA. [Endara, Skye M.; Macera, Caroline A.; Smith, Tyler C.] San Diego State Univ, Grad Sch Publ Hlth, Div Epidemiol & Biostat, San Diego, CA 92182 USA. RP Conlin, AMS (reprint author), USN, Hlth Res Ctr, US Dept Def, Ctr Deployment Hlth Res, San Diego, CA 92152 USA. EM sendara@gmail.com; margaret.ryan@med.navy.mil; carter.sevick@med.navy.mil; ava.conlin@med.navy.mil; cmacera@mail.sdsu.edu; tyler.c.smith@med.navy.mil NR 42 TC 11 Z9 11 U1 5 U2 10 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD JUL 20 PY 2009 VL 9 AR 252 DI 10.1186/1471-2458-9-252 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 492MU UT WOS:000269663300001 PM 19619310 ER PT J AU Garten, RJ Davis, CT Russell, CA Shu, B Lindstrom, S Balish, A Sessions, WM Xu, XY Skepner, E Deyde, V Okomo-Adhiambo, M Gubareva, L Barnes, J Smith, CB Emery, SL Hillman, MJ Rivailler, P Smagala, J de Graaf, M Burke, DF Fouchier, RAM Pappas, C Alpuche-Aranda, CM Lopez-Gatell, H Olivera, H Lopez, I Myers, CA Faix, D Blair, PJ Yu, C Keene, KM Dotson, PD Boxrud, D Sambol, AR Abid, SH George, KS Bannerman, T Moore, AL Stringer, DJ Blevins, P Demmler-Harrison, GJ Ginsberg, M Kriner, P Waterman, S Smole, S Guevara, HF Belongia, EA Clark, PA Beatrice, ST Donis, R Katz, J Finelli, L Bridges, CB Shaw, M Jernigan, DB Uyeki, TM Smith, DJ Klimov, AI Cox, NJ AF Garten, Rebecca J. Davis, C. Todd Russell, Colin A. Shu, Bo Lindstrom, Stephen Balish, Amanda Sessions, Wendy M. Xu, Xiyan Skepner, Eugene Deyde, Varough Okomo-Adhiambo, Margaret Gubareva, Larisa Barnes, John Smith, Catherine B. Emery, Shannon L. Hillman, Michael J. Rivailler, Pierre Smagala, James de Graaf, Miranda Burke, David F. Fouchier, Ron A. M. Pappas, Claudia Alpuche-Aranda, Celia M. Lopez-Gatell, Hugo Olivera, Hiram Lopez, Irma Myers, Christopher A. Faix, Dennis Blair, Patrick J. Yu, Cindy Keene, Kimberly M. Dotson, P. David, Jr. Boxrud, David Sambol, Anthony R. Abid, Syed H. George, Kirsten St. Bannerman, Tammy Moore, Amanda L. Stringer, David J. Blevins, Patricia Demmler-Harrison, Gail J. Ginsberg, Michele Kriner, Paula Waterman, Steve Smole, Sandra Guevara, Hugo F. Belongia, Edward A. Clark, Patricia A. Beatrice, Sara T. Donis, Ruben Katz, Jacqueline Finelli, Lyn Bridges, Carolyn B. Shaw, Michael Jernigan, Daniel B. Uyeki, Timothy M. Smith, Derek J. Klimov, Alexander I. Cox, Nancy J. TI Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans SO SCIENCE LA English DT Article ID A VIRUS; PHYLOGENETIC ANALYSIS; UNITED-STATES; NORTH-AMERICA; EVOLUTION; PIGS; PATHOGENICITY; TRANSMISSION; EMERGENCE; INFECTION AB Since its identification in April 2009, an A(H1N1) virus containing a unique combination of gene segments from both North American and Eurasian swine lineages has continued to circulate in humans. The lack of similarity between the 2009 A(H1N1) virus and its nearest relatives indicates that its gene segments have been circulating undetected for an extended period. Its low genetic diversity suggests that the introduction into humans was a single event or multiple events of similar viruses. Molecular markers predictive of adaptation to humans are not currently present in 2009 A(H1N1) viruses, suggesting that previously unrecognized molecular determinants could be responsible for the transmission among humans. Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1). C1 [Russell, Colin A.; Skepner, Eugene; de Graaf, Miranda; Burke, David F.; Smith, Derek J.] Univ Cambridge, Dept Zool, Cambridge CB2 3EJ, England. [Garten, Rebecca J.; Davis, C. Todd; Shu, Bo; Lindstrom, Stephen; Balish, Amanda; Sessions, Wendy M.; Xu, Xiyan; Skepner, Eugene; Deyde, Varough; Okomo-Adhiambo, Margaret; Gubareva, Larisa; Barnes, John; Smith, Catherine B.; Emery, Shannon L.; Hillman, Michael J.; Rivailler, Pierre; Smagala, James; Pappas, Claudia; Guevara, Hugo F.; Belongia, Edward A.; Clark, Patricia A.; Beatrice, Sara T.; Donis, Ruben; Katz, Jacqueline; Finelli, Lyn; Bridges, Carolyn B.; Shaw, Michael; Jernigan, Daniel B.; Uyeki, Timothy M.; Klimov, Alexander I.; Cox, Nancy J.] Ctr Dis Control & Prevent CDC, WHO, Collaborating Ctr Influenza, Atlanta, GA 30333 USA. [Russell, Colin A.; Smith, Derek J.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. [de Graaf, Miranda; Fouchier, Ron A. M.; Smith, Derek J.] Erasmus MC, Dept Virol, NL-3000 CA Rotterdam, Netherlands. [Alpuche-Aranda, Celia M.; Lopez-Gatell, Hugo; Olivera, Hiram; Lopez, Irma] InDRE Prolongac Carpio, Mexico City 11340, DF, Mexico. [Myers, Christopher A.; Faix, Dennis; Blair, Patrick J.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Yu, Cindy] Arizona State Publ Hlth Lab, Phoenix, AZ 85007 USA. [Keene, Kimberly M.] Colorado Dept Publ Hlth & Environm, Denver, CO 80230 USA. [Dotson, P. David, Jr.] Indiana State Dept Hlth Labs, Indianapolis, IN 46202 USA. [Boxrud, David] Minnesota Dept Hlth, Publ Hlth Lab, St Paul, MN 55164 USA. [Sambol, Anthony R.] Nebraska Publ Hlth Lab, Omaha, NE 68198 USA. [Abid, Syed H.] Westchester Cty Dept Labs & Res Publ Hlth Labs, Valhalla, NY 10595 USA. [George, Kirsten St.] New York State Dept Hlth, Wadsworth Ctr, Slingerlands, NY USA. [Bannerman, Tammy] Ohio Dept Hlth Lab, Reynoldsburg, OH USA. [Moore, Amanda L.] S Carolina Dept Hlth & Environm Control, Columbia, SC 29223 USA. [Stringer, David J.] Dallas Cty Hlth & Human Serv, Dallas, TX 75207 USA. [Blevins, Patricia] San Antonio Metro Hlth Dist, Brooks City Base, TX 78235 USA. [Demmler-Harrison, Gail J.] Texas Childrens Hosp, Diagnost Virol Lab, Houston, TX 77030 USA. [Ginsberg, Michele] San Diego Publ Hlth Lab, San Diego, CA 92186 USA. [Kriner, Paula] Imperial Cty Publ Hlth Dept, El Centro, CA 92243 USA. [Waterman, Steve] CDC, Border Infect Dis Surveillance Project, Atlanta, GA 30333 USA. [Smole, Sandra] Massachusetts Dept Publ Hlth, William A Hinton State Lab Inst, Jamaica Plain, MA 02130 USA. [Guevara, Hugo F.] Calif Dept Publ Hlth, Viral & Rickettsial Dis Lab, Richmond, CA 94804 USA. [Belongia, Edward A.] Marshfield Clin Fdn Med Res & Educ, Marshfield, WI 54449 USA. [Clark, Patricia A.] Michigan Dept Community Hlth, Lansing, MI 48906 USA. [Beatrice, Sara T.] NYU, Dept Hlth & Mental Hyg, Publ Hlth Lab, New York, NY 10016 USA. RP Smith, DJ (reprint author), Univ Cambridge, Dept Zool, Downing St, Cambridge CB2 3EJ, England. EM dsmith@zoo.cam.ac.uk; njc1@cdc.gov RI Bannerman, Tammy/E-2694-2011; burke, david/C-2091-2013; Valle, Ruben/A-7512-2013; Fouchier, Ron/A-1911-2014; OI Fouchier, Ron/0000-0001-8095-2869; burke, david/0000-0001-8830-3951; Russell, Colin/0000-0002-2113-162X FU National Institute of Allergy and Infectious Diseases [HHSN266200700010C]; International Federation of Pharmaceutical Manufacturers and Associations [RG51953]; Research Fellowship from Clare College, Cambridge; NIH [DP1-OD000490-01]; European Union [223498 EMPERIE]; Human Frontier Science Program [RG P0050/2008] FX We thank the many individuals at the local, state, and national levels for their enormous contributions to the surveillance of the 2009 A(H1N1) virus; the entire CDC Influenza Division staff and emergency staff; the maintainers of the GISAID EpiFluDB and NCBI GenBank/IVR, and the members of the WHO Global Influenza Surveillance Network. The findings and conclusions of this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. R.A.M.F. was supported by National Institute of Allergy and Infectious Diseases under NIH contract HHSN266200700010C. E.S. was supported in part by the International Federation of Pharmaceutical Manufacturers and Associations through grant RG51953. C.A.R. was supported in part by a Research Fellowship from Clare College, Cambridge. D.J.S., C.A.R., E.S., and D.F.B. were supported by an NIH Directors Pioneer Award, part of the NIH roadmap for medical research, through grant DP1-OD000490-01, an FP7 grant, 223498 EMPERIE, from the European Union, and program grant RG P0050/2008 from the Human Frontier Science Program. GenBank accession numbers are listed in the Supporting Online Material NR 38 TC 1372 Z9 1481 U1 16 U2 217 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 J9 SCIENCE JI Science PD JUL 10 PY 2009 VL 325 IS 5937 BP 197 EP 201 DI 10.1126/science.1176225 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 468FK UT WOS:000267802000046 PM 19465683 ER PT J AU Manock, SR Jacobsen, KH de Bravo, NB Russell, KL Negrete, M Olson, JG Sanchez, JL Blair, PJ Smalligan, RD Quist, BK Espin, JF Espinoza, WR MacCormick, F Fleming, LC Kochel, T AF Manock, Stephen R. Jacobsen, Kathryn H. Brito de Bravo, Narcisa Russell, Kevin L. Negrete, Monica Olson, James G. Sanchez, Jose L. Blair, Patrick J. Smalligan, Roger D. Quist, Brad K. Freire Espin, Juan Espinoza, Willan R. MacCormick, Fiona Fleming, Lila C. Kochel, Tadeusz TI Etiology of Acute Undifferentiated Febrile Illness in the Amazon Basin of Ecuador SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID ACUTE Q-FEVER; HOSPITALIZED-PATIENTS; DENGUE VIRUS; PUERTO-RICO; LEPTOSPIROSIS; DIAGNOSIS; INFECTION; ADULTS; TRAVELERS; EPIDEMIC AB We conducted a longitudinal observational study of 533 patients presenting to two hospitals in the Ecuadorean Amazon basin with acute undifferentiated febrile illness (AUFI) from 2001 through 2004. Viral isolation, reverse transcription-polymerase chain reaction (RT-PCR), IgM seroconversion, and malaria smears identified pathogens responsible for fever in 122 (40.1%) of 304 patients who provided both acute and convalescent blood samples. Leptospirosis was found in 40 (13.2%), malaria in 38 (12.5%), rickettsioses in 18 (5.9%), dengue fever in 16 (5.3%), Q fever in 1.5 (4.9%), brucellosis in 4 (1.3%), Ilheus infection in 3 (1.0%), and Venezuelan equine encephalitis (VEE), Oropouche, and St. Louis encephalitis virus infections in less than 1% of these patients. Viral isolation and RT-PCR on another 229 participants who provided only acute samples identified 3 cases of dengue fever, 2 of VEE, and 1 of Ilheus. None of these pathogens, except for malaria, had previously been detected in the study area. C1 [Jacobsen, Kathryn H.; Fleming, Lila C.] George Mason Univ, Dept Global & Community Hlth, Fairfax, VA 22030 USA. [Manock, Stephen R.] Rural Med Serv, Parrottsville, TN 37843 USA. [Brito de Bravo, Narcisa] Hosp Vozandes Oriente, Shell, Pastaza, Ecuador. [Russell, Kevin L.; Sanchez, Jose L.] Armed Forces Hlth Surveillance Ctr, Dept Def Global Emerging Surveillance & Response, Silver Spring, MD 20910 USA. [Negrete, Monica] I TECH, Maputo, Mozambique. [Blair, Patrick J.] Naval Hlth Res Ctr, San Diego, CA 92106 USA. [Smalligan, Roger D.] E Tennessee State Univ, Quillen Coll Med, Johnson City, TN 37604 USA. E Tennessee State Univ, Dept Internal Med, Johnson City, TN 37604 USA. [Quist, Brad K.] HCJB Global, Community Dev Dept, Quito, Ecuador. [Freire Espin, Juan] Hosp Gen Fuerzas Armadas, Dept Med Interna, Quito, Ecuador. [Espinoza, Willan R.] Policlin Militar San Jorge, Sangolqui, Pichincha, Ecuador. [MacCormick, Fiona] W Cumberland Dist Gen Hosp, N Cumbria Acute Hosp NHS Trust, Whitehaven CA28 8JG, Cumbria, England. [Kochel, Tadeusz] US Med Res Ctr Detachment, Lima, Peru. US Naval Med Res Ctr Detachment, Lima, Peru. RP Jacobsen, KH (reprint author), George Mason Univ, Dept Global & Community Hlth, 4400 Univ Dr 5B7, Fairfax, VA 22030 USA. EM stevemanock@yahoo.com; kjacobse@gmu.edu; nbrito@hcjb.org.ec; kevin.russell4@us.army.mil; monican@itech-mozambique.org; payara@comcast.net; toti.sanchez@us.army.mil; Patrick.Blair@med.navy.mil; smalliga@mail.etsu.edu; bquist@hcjb.org.ec; juanfreire52@yahoo.es; wrespinozas@yahoo.com; fionamaccormick@doctors.org.uk; lflemin1@gmu.edu; Tad.Kochel@med.navy.mil RI Jacobsen, Kathryn/B-5857-2008; Valle, Ruben/A-7512-2013; OI Jacobsen, Kathryn/0000-0002-4198-6246; Fleming, Lila/0000-0002-5556-2831 FU United States Department of Defense Global Emerging Infections Systems Research Program [847705.82000.25GB.B0016] FX This study was funded by the United States Department of Defense Global Emerging Infections Systems Research Program, WORK UNIT NUMBER: 847705.82000.25GB.B0016. NR 44 TC 29 Z9 32 U1 0 U2 8 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 2009 VL 81 IS 1 BP 146 EP 151 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 464SI UT WOS:000267526500025 PM 19556580 ER PT J AU Garland, CF AF Garland, Cedric F. TI Symposium in Print on the Epidemiology of Vitamin D and Cancer SO ANNALS OF EPIDEMIOLOGY LA English DT Editorial Material C1 [Garland, Cedric F.] Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA. [Garland, Cedric F.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. RP Garland, CF (reprint author), Univ Calif San Diego, Dept Family & Prevent Med, 9500 Gilman Dr 0631C, La Jolla, CA 92093 USA. NR 11 TC 2 Z9 2 U1 1 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1047-2797 J9 ANN EPIDEMIOL JI Ann. Epidemiol. PD JUL PY 2009 VL 19 IS 7 BP 439 EP 440 DI 10.1016/j.annepidem.2009.02.002 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 460QM UT WOS:000267202200001 PM 19342255 ER PT J AU Garland, CF Gorham, ED Mohr, SB Garland, FC AF Garland, Cedric F. Gorham, Edward D. Mohr, Sharif B. Garland, Frank C. TI Vitamin D for Cancer Prevention: Global Perspective SO ANNALS OF EPIDEMIOLOGY LA English DT Review DE Vitamin D; Breast Neoplasms; Colorectal Neoplasms; Ovarian Neoplasms; Dose-Response; Calcium; Etiology; Prevention; Treatment; Survival ID ULTRAVIOLET-B IRRADIANCE; CULTURED HUMAN KERATINOCYTES; AFRICAN-AMERICAN WOMEN; MYELOID-LEUKEMIA CELLS; D METABOLITE LEVELS; BREAST-CANCER; PROSTATE-CANCER; COLON-CANCER; COLORECTAL-CANCER; D SUPPLEMENTATION AB PURPOSE: Higher serum levels of the main circulating form of vitamin D, 25-hydroxyvitamin D (25(OH)D), are associated with substantially lower incidence rates of colon, breast, ovarian, renal, pancreatic, aggressive prostate and other cancers. METHODS: Epidemiological findings combined with newly discovered mechanisms suggest a new model of cancer etiology that accounts for these actions of 25(OH)D and calcium. Its seven phases are disjunction, initiation, natural selection, overgrowth, metastasis, involution, and transition (abbreviated DINOMIT). Vitamin D metabolites prevent disjunction of cells and are beneficial in other phases. RESULTS/CONCLUSIONS: It is projected that raising the minimum year-around serum 25(OH)D level to 40 to 60 ng/mL (100-150 nmol/L) would prevent approximately 58,000 new cases of breast cancer and 49,000 new cases of colorectal cancer each year, and three fourths of deaths from these diseases in the United States and Canada, based on observational studies combined with a randomized trial. Such intakes also are expected to reduce case-fatality rates of patients who have breast, colorectal, or prostate cancer by half. There are no unreasonable risks from intake of 2000 IU per day of vitamin D(3), or from a population serum 25(OH)D level of 40 to 60 ng/mL. The time has arrived for nationally coordinated action to substantially increase intake of vitamin D and calcium. Ann Epidemiol 2009; 19:468-483. (C) Published by Elsevier Inc. C1 [Gorham, Edward D.; Garland, Frank C.] USN, Hlth Res Ctr, San Diego, CA 92186 USA. [Garland, Cedric F.; Gorham, Edward D.; Mohr, Sharif B.; Garland, Frank C.] Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA. [Garland, Cedric F.; Gorham, Edward D.; Mohr, Sharif B.; Garland, Frank C.] Moores Univ Calif San Diego, Ctr Canc, La Jolla, CA USA. RP Gorham, ED (reprint author), USN, Hlth Res Ctr, POB 85122, San Diego, CA 92186 USA. EM edward.gorham@med.navy.mil FU Special Interest Congressional Project allocation; Bureau of Medicine and Surgery; Naval Health Research Center in San Diego, CA FX This research was partially supported by a Special Interest Congressional Project allocation to the Penn State Cancer Institute of the Milton S. Hershey Medical Center (Hershey, PA) through the Department of the Navy, Bureau of Medicine and Surgery, and the Naval Health Research Center in San Diego, CA, Work Unit No. 60126. The views expressed in this report are those of the authors and do not represent an official position of the Department of the Navy, Department of Defense, or the U. S. Government. NR 144 TC 206 Z9 217 U1 3 U2 33 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1047-2797 J9 ANN EPIDEMIOL JI Ann. Epidemiol. PD JUL PY 2009 VL 19 IS 7 BP 468 EP 483 DI 10.1016/j.annepidem.2009.03.021 PG 16 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 460QM UT WOS:000267202200006 PM 19523595 ER PT J AU Dougherty, AL Mohrle, CR Galarneau, MR Woodruff, SI Dye, JL Quinn, KH AF Dougherty, Amber L. Mohrle, Charlene R. Galarneau, Michael R. Woodruff, Susan I. Dye, Judy L. Quinn, Kimberly H. TI Battlefield extremity injuries in Operation Iraqi Freedom SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED LA English DT Article DE Extremity injury; Combat casualty; Severity; Military; Operation Iraqi Freedom ID COMBAT TRAUMA REGISTRY; NECK INJURIES; UNITED-STATES; EXPERIENCE; CASUALTIES; ARMY; HEAD AB Objective: Extremity injuries account for the majority of wounds incurred during US armed conflicts. Information regarding the severity and short-term outcomes of patients with extremity wounds, however, is limited. The aim of the present study was to describe patients with battlefield extremity injuries in Operation Iraqi Freedom (OIF) and to compare characteristics of extremity injury patients with other combat wounded. Patients and methods: Data were obtained from the United States Navy-Marine Corps Combat Trauma Registry (CTR) for patients who received treatment for combat wounds at Navy-Marine Corps facilities in Iraq between September 2004 and February 2005. Battlefield extremity injuries were classified according to type, location, and severity: patient demographic, injury-specific, and short-term outcome data were analysed. Upper and lower extremity injuries were also compared. Results: A total of 935 combat wounded patients were identified; 665 (71%) sustained extremity injury. Overall, multiple wounding was common (an average of 3 wounds per patient), though more prevalent amongst patients with extremity injury than those with other injury (75% vs. 56%, P < .001). Amongst the 665 extremity injury patients, 261 (39%) sustained injury to the upper extremities, 223 (34%) to the lower extremities, and 181 (27%) to both the upper and lower extremities. Though the total number of patients with upper extremity injury was higher than lower extremity injury, the total number of extremity wounds (n = 1654) was evenly distributed amongst the upper and lower extremities (827 and 827 wounds, respectively). Further, lower extremity injuries were more likely than the upper extremity injuries to be coded as serious to fatal (AIS > 2, P < .001). Conclusions: Extremity injuries continue to account for the majority of combat wounds. Compared with other conflicts, OIF has seen increased prevalence of patients with upper extremity injuries. Wounds to the lower extremities, however, are more serious. Further research on the risks and outcomes associated with extremity injury is necessary to enhance the planning and delivery of combat casualty medical care. (c) 2009 Elsevier Ltd. All rights reserved. C1 [Dougherty, Amber L.; Mohrle, Charlene R.; Woodruff, Susan I.; Dye, Judy L.; Quinn, Kimberly H.] Sci Applicat Int Corp, Hlth Res & Appl Technol Div, San Diego, CA 92121 USA. [Dougherty, Amber L.; Galarneau, Michael R.] USN, Hlth Res Ctr, Dept Med Modeling Simulat & Mission Support, San Diego, CA 92106 USA. RP Dougherty, AL (reprint author), USN, Hlth Res Ctr, Dept Med Modeling Simulat & Mission Support, 140 Sylvester Rd, San Diego, CA 92106 USA. EM amber.dougherty@med.navy.mil FU United States Office of Naval Research; Casualty Care Management, Arlington, Virginia [60802]; United States Office of the Secretary of Defense Business Transformation Agency (BTA); Warfighter Support Office, Arlington, Virginia [60829] FX The work was supported by the United States Office of Naval Research, Casualty Care Management, Arlington, Virginia under Work Unit No. 60802 and the United States Office of the Secretary of Defense Business Transformation Agency (BTA), Warfighter Support Office, Arlington, Virginia under Work Unit No. 60829. The views and opinions expressed herein are those of the authors and do not necessarily reflect the official policy or position of the United States Navy, Department of Defense, nor the US Government. NR 22 TC 35 Z9 36 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0020-1383 J9 INJURY JI Injury-Int. J. Care Inj. PD JUL PY 2009 VL 40 IS 7 BP 772 EP 777 DI 10.1016/j.injury.2009.02.014 PG 6 WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery GA 467JE UT WOS:000267734000019 PM 19450798 ER PT J AU Fonseca, V Davis, M Wing, R Kriner, P Lopez, K Blair, PJ Faix, D Goldbaum, G Bruce, H Nelson, M Marfin, AA Jamieson, DJ MacFarlane, K Rasmussen, SA Honein, MA Finelli, L Uyeki, T Gross, D Fiore, A Olsen, SJ Swerdlow, DL Barzilay, EJ Menon, M O'Reilly, CE Dharan, N Patel, MK AF Fonseca, V. Davis, M. Wing, R. Kriner, P. Lopez, K. Blair, P. J. Faix, D. Goldbaum, G. Bruce, H. Nelson, M. Marfin, A. A. Jamieson, D. J. MacFarlane, K. Rasmussen, S. A. Honein, M. A. Finelli, L. Uyeki, T. Gross, D. Fiore, A. Olsen, S. J. Swerdlow, D. L. Barzilay, E. J. Menon, M. O'Reilly, C. E. Dharan, N. Patel, M. K. TI Novel Influenza A (H1N1) Virus Infections in Three Pregnant Women-United States, April-May 2009 (Reprinted from MMWR, vol 58, pg 497-500, 2009) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Blair, P. J.; Faix, D.] Naval Hlth Res Ctr, San Diego, CA USA. [Dharan, N.; Patel, M. K.] CDC, Atlanta, GA 30333 USA. RI Valle, Ruben/A-7512-2013 NR 1 TC 2 Z9 2 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD JUL 1 PY 2009 VL 302 IS 1 BP 23 EP 25 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 464GH UT WOS:000267492800005 ER PT J AU Houng, HSH Lott, L Gong, HP Kuschner, RA Lynch, JA Metzgar, D AF Houng, Huo-Shu H. Lott, Lisa Gong, Heping Kuschner, Robert A. Lynch, Julia A. Metzgar, David TI Adenovirus Microsatellite Reveals Dynamics of Transmission during a Recent Epidemic of Human Adenovirus Serotype 14 Infection SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID RESPIRATORY ADENOVIRUS; SEQUENCE-ANALYSIS; IDENTIFICATION; EVOLUTION; OUTBREAK; TYPE-7; GENOME; REGION; GENE; TOOL AB This study reveals diverse-length polymorphisms in long mononucleotide repeats (microsatellites) in several serotypes of epidemic human respiratory adenovirus. The length of one of these microsatellites, a homopolymeric thymidine [poly( T)] repeat, is measured in 68 isolates of adenovirus serotype 14. These isolates were collected during a series of sudden and sometimes fatal outbreaks among both military recruits and civilians as the virus emerged for the first time in the United States in 2006 and 2007. The results demonstrate the usefulness of adenoviral microsatellites as high-resolution molecular strain markers. The described homopolymer is hypervariable in length, varying from 12 to 17 bp in the analyzed sample set. All intermediate lengths were identified in at least one isolate. Furthermore, the specific length of the marker is stable for significant periods of time (up to 7 months) at individual sites where the virus is in consistent circulation. The microsatellite also can maintain specific length identity through site-to-site transmission events, as determined by the analysis of isolates from three advanced training sites that appeared to be subject to pathogen transfer from one of the affected recruit training installations. Public database searches revealed that the polymorphic nature of the microsatellite extends to other species B serotypes, and that other polymorphic microsatellites can be identified readily in a variety of epidemic respiratory adenovirus clades. This study shows that microsatellites are a ubiquitous source of polymorphic markers for human adenoviruses and demonstrates their use through an epidemiological analysis of isolates from a recent North American epidemic. C1 [Metzgar, David] USN, Hlth Res Ctr, Dept Resp Dis Res, San Diego, CA 92106 USA. [Houng, Huo-Shu H.; Gong, Heping; Kuschner, Robert A.; Lynch, Julia A.] Walter Reed Army Inst Res, Div Viral Dis, Silver Spring, MD USA. [Lott, Lisa] Off AF Surg Gen, Adv Diagnost Lab, Lackland AFB, TX USA. RP Metzgar, D (reprint author), USN, Hlth Res Ctr, Dept Resp Dis Res Code 166, 140 Sylvester Rd, San Diego, CA 92106 USA. EM david.metzgar@med.navy.mil RI Valle, Ruben/A-7512-2013 FU Department of Defense Global Emerging Infections Surveillance and Response System [6609] FX The views expressed in this work are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of the Army, Department of the Air Force, Department of Defense (DoD), or U. S. government. This research has been conducted in compliance with all applicable federal and international regulations governing the protection of human subjects in research (DoD protocol NHRC. 1999.0002). We declare that no conflict of interest exists. NR 26 TC 7 Z9 7 U1 1 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JUL PY 2009 VL 47 IS 7 BP 2243 EP 2248 DI 10.1128/JCM.01659-08 PG 6 WC Microbiology SC Microbiology GA 467CC UT WOS:000267713000036 PM 19403773 ER PT J AU Aktas, E Seaver, M Nichols, JM Trickey, ST Davis, WR AF Aktas, E. Seaver, M. Nichols, J. M. Trickey, S. T. Davis, W. R. TI The Influence of Low Energy Impacts on the Static and Dynamic Response of a Foam Core Composite Wing SO JOURNAL OF INTELLIGENT MATERIAL SYSTEMS AND STRUCTURES LA English DT Article DE Structural Health Monitoring (SHM); fiber optic sensors; non-destructive testing; sandwich composite airfoil; low velocity impact damage; delamination ID DAMAGE DETECTION; SANDWICH COMPOSITES; FATIGUE; TORSION; BEAM; LIFE AB This work describes damage detection efforts on a composite wing subject to a series of low-energy (similar to 7 J) impacts. Two airfoils with fundamentally different damage scenarios were considered. The first damage scenario produced no visible signs of damage on the wing surface following eight impacts. A duplicate wing, subjected to a similar series of impacts, was investigated using flash thermography and subsequently autopsied. The flash thermography showed small, localized damage in the skin, but gave no information about core damage. The autopsy showed core/skin disbonding at both interfaces that varied with the number of impacts, core crushing, and a through the core shear crack. No clear changes to the static or dynamic wing response were observed for this scenario. The second damage scenario involved cracking of the wing skin. While damage quantification was not undertaken for this scenario, both static and dynamic changes in wing response were observed. An analytical model of the wing is presented which helps explain the observed behaviors of the two damage scenarios. C1 [Aktas, E.] Izmir Inst Technol, Dept Civil Engn, TR-35430 Urla Izmir, Turkey. [Seaver, M.; Nichols, J. M.; Trickey, S. T.] USN, Res Lab, Washington, DC 20375 USA. [Davis, W. R.] USN, Air Warfare Ctr, Div Aircraft, Patuxent River, MD 20670 USA. RP Aktas, E (reprint author), Izmir Inst Technol, Dept Civil Engn, TR-35430 Urla Izmir, Turkey. EM enginaktas@iyte.edu.tr NR 19 TC 1 Z9 1 U1 0 U2 3 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1045-389X J9 J INTEL MAT SYST STR JI J. Intell. Mater. Syst. Struct. PD JUL PY 2009 VL 20 IS 11 BP 1351 EP 1361 DI 10.1177/1045389X08095184 PG 11 WC Materials Science, Multidisciplinary SC Materials Science GA 463NT UT WOS:000267439600007 ER PT J AU Gronroos, NN Zouris, JM Wade, AL AF Gronroos, Noelle N. Zouris, James M. Wade, Amber L. TI Odds of Hospitalization Among Marine Corps Personnel by Military Occupational Specialty and Causative Agents During OEF and OIF SO MILITARY MEDICINE LA English DT Article ID OPERATION ENDURING FREEDOM; IRAQI-FREEDOM; COMBAT; INJURIES; SOLDIERS; WOUNDS AB Objective: This study investigated the risk of hospitalization among Marines deployed during Operations Enduring and Iraqi Freedom by military occupational specialty (MOS). Methods: Trends in risk of hospitalization as a function of injury cause (explosive munitions and small arms [EM/SA]), anatomical location, and injury type were analyzed to identify which MOSs were more likely to have open wound injuries or trauma to the extremities. The study population consisted of 163,939 Marines deployed at any time during the study period (September 11, 2001-January 31, 2007). Hospitalized Marines (n = 2,718) were matched to nonhospitalized Marines on rank, time deployed, and number of deployments. Results: Noninfantry MOSs had lower risk of hospitalization compared with infantry, regardless of injury cause or location. Trends differed for EM/SA versus other injury causative agents, but did not differ by anatomical location among EM/SA. Conclusion: This information allows for quantitative assessment of risk by MOS in combat situations. C1 [Gronroos, Noelle N.] San Diego State Univ, Res Fdn, San Diego, CA 92182 USA. [Gronroos, Noelle N.; Zouris, James M.; Wade, Amber L.] USN, Hlth Res Ctr, San Diego, CA 92106 USA. RP Gronroos, NN (reprint author), San Diego State Univ, Res Fdn, 5250 Campanile Dr, San Diego, CA 92182 USA. FU Science Applications International Corporation; Office of Naval Research, Arlington, VA; Marine Corps Warfighting Laboratory [63706N.M0095.60511] FX This research could have not been done without various key personnel. We thank Thierry Nedellac; Paula Konoske, PhD; Michael Galarneau, MS; and Michelle Stoia from the Naval Health Research Center as well as the Defense Manpower Data Center. We appreciate the support of the Science Applications International Corporation, 10260 Campus Point Dr., San Diego, CA 92121. This research was supported by the Office of Naval Research, Arlington, VA, and the Marine Corps Warfighting Laboratory under Work Unit No. 63706N.M0095.60511. NR 14 TC 1 Z9 1 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2009 VL 174 IS 7 BP 715 EP 720 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 601LE UT WOS:000278060100008 PM 19685843 ER PT J AU Larson, GE Booth-Kewley, S Highfill-McRoy, RM Young, SYN AF Larson, Gerald E. Booth-Kewley, Stephanie Highfill-McRoy, Robyn M. Young, Sylvia Y. N. TI Prospective Analysis of Psychiatric Risk Factors in Marines Sent to War SO MILITARY MEDICINE LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; ADVERSE CHILDHOOD EXPERIENCES; VIETNAM VETERANS; SYMPTOMS; EXPOSURE; SMOKING; EVENTS; TRAUMA; PTSD AB The objective of this longitudinal study was to identify risk factors for combat-related psychiatric disorders. The sample consisted of 6,442 enlisted U.S. Marines who completed a questionnaire during basic training, deployed to a combat zone with no prior psychiatric diagnoses, and completed a postdeployment assessment form. Cox proportional hazards regression was used to determine associations between predeployment and postdeployrnent self-reports and subsequent mental health outcomes. During the observation period, 6.8% of the sample were diagnosed with a psychiatric disorder. The strongest predictors of postdeployment psychiatric disorders were, in order of importance, low paygrade, hospitalization during deployment, low education, preservice smoking, and post-traumatic stress disorder symptoms at deployment's end. The impact of war zone variables was smaller than expected. It was recommended that the combat experience section of the military's postdeployment assessment form be expanded to enhance the military's ability to identify and refer personnel who may be at risk for psychiatric disorders. C1 [Larson, Gerald E.; Booth-Kewley, Stephanie; Highfill-McRoy, Robyn M.] USN, Hlth Res Ctr, San Diego, CA 92106 USA. [Highfill-McRoy, Robyn M.] Sci Applicat Int Corp Inc, San Diego, CA 92121 USA. [Young, Sylvia Y. N.] USN, San Diego Med Ctr, San Diego, CA 92134 USA. RP Larson, GE (reprint author), USN, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. FU Bureau of Medicine and Surgery [60518] FX The authors thank Dr. Cedric Garland for providing helpful comments on the manuscript. This report was supported by the Bureau of Medicine and Surgery, under Work Unit No. 60518. NR 33 TC 6 Z9 7 U1 2 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2009 VL 174 IS 7 BP 737 EP 744 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 601LE UT WOS:000278060100011 PM 19685846 ER PT J AU Paulus, MP Potterat, EG Taylor, MK Van Orden, KF Bauman, J Momen, N Padilla, GA Swaine, JL AF Paulus, Martin P. Potterat, Eric G. Taylor, Marcus K. Van Orden, Karl F. Bauman, James Momen, Nausheen Padilla, Genieleah A. Swaine, Judith L. TI A neuroscience approach to optimizing brain resources for human performance in extreme environments SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS LA English DT Review DE Performance; Stress; Elite athlete; Warfighter; Sport; Cognition; Emotion ID CORTICOTROPIN-RELEASING-FACTOR; ANTERIOR CINGULATE CORTEX; COGNITIVE PERFORMANCE; PSYCHOLOGICAL MEASURES; CENTRAL NUCLEUS; SPACE MISSIONS; SLEEP LOSS; STRESS; BEHAVIOR; ANXIETY AB Extreme environments requiring optimal cognitive and behavioral performance occur in a wide variety of situations ranging from complex combat operations to elite athletic competitions. Although a large literature characterizes psychological and other aspects of individual differences in performances in extreme environments, virtually nothing is known about the underlying neural basis for these differences. This review summarizes the cognitive, emotional, and behavioral consequences of exposure to extreme environments, discusses predictors of performance, and builds a case for the use of neuroscience approaches to quantify and understand optimal cognitive and behavioral performance. Extreme environments are defined as an external context that exposes individuals to demanding psychological and/or physical conditions, and which may have profound effects on cognitive and behavioral performance. Examples of these types of environments include combat situations, Olympic-level competition, and expeditions in extreme cold, at high altitudes, or in space. Optimal performance is defined as the degree to which individuals achieve a desired outcome when completing goal-oriented tasks. It is hypothesized that individual variability with respect to optimal performance in extreme environments depends on a well "contextualized" internal body state that is associated with an appropriate potential to act. This hypothesis can be translated into an experimental approach that may be useful for quantifying the degree to which individuals are particularly suited to performing optimally in demanding environments. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Paulus, Martin P.; Swaine, Judith L.] Univ Calif San Diego, San Diego, CA 92037 USA. [Taylor, Marcus K.; Van Orden, Karl F.; Momen, Nausheen; Padilla, Genieleah A.] Naval Hlth Res Ctr, San Diego, CA 92186 USA. [Bauman, James] US Olympic Training Ctr, Chula Vista, CA 91915 USA. [Potterat, Eric G.] Naval Special Warfare Ctr, San Diego, CA 92155 USA. [Paulus, Martin P.; Potterat, Eric G.; Taylor, Marcus K.; Van Orden, Karl F.; Bauman, James; Momen, Nausheen; Padilla, Genieleah A.; Swaine, Judith L.] OptiBrain Consortium, La Jolla, CA 92037 USA. [Swaine, Judith L.] Natl Univ Singapore, Singapore 117548, Singapore. [Swaine, Judith L.] ASTAR, Singapore Inst Clin Sci, Singapore, Singapore. RP Paulus, MP (reprint author), Univ Calif San Diego, 9500 Gilman Dr, San Diego, CA 92037 USA. EM mpaulus@ucsd.edu FU NIDA NIH HHS [R03 DA020687-02, R03 DA020687] NR 77 TC 21 Z9 23 U1 4 U2 31 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0149-7634 J9 NEUROSCI BIOBEHAV R JI Neurosci. Biobehav. Rev. PD JUL PY 2009 VL 33 IS 7 BP 1080 EP 1088 DI 10.1016/j.neubiorev.2009.05.003 PG 9 WC Behavioral Sciences; Neurosciences SC Behavioral Sciences; Neurosciences & Neurology GA 475QM UT WOS:000268375300008 PM 19447132 ER PT J AU Baca, AJ Truong, TT Cambrea, LR Montgomery, JM Gray, SK Abdula, D Banks, TR Yao, JM Nuzzo, RG Rogers, JA AF Baca, Alfred J. Truong, Tu T. Cambrea, Lee R. Montgomery, Jason M. Gray, Stephen K. Abdula, Daner Banks, Tony R. Yao, Jimin Nuzzo, Ralph G. Rogers, John A. TI Molded plasmonic crystals for detecting and spatially imaging surface bound species by surface-enhanced Raman scattering SO APPLIED PHYSICS LETTERS LA English DT Article DE monolayers; nanofabrication; nanolithography; nanostructured materials; plasmonics; soft lithography; surface enhanced Raman scattering ID SPECTROSCOPY; MONOLAYERS AB This report introduces a type of plasmonic crystal that consists of metal coated nanostructures of relief molded on a polymer film as a substrate for surface-enhanced Raman scattering (SERS). Such crystals exhibit SERS enhancement factors of similar to 10(5), over large areas and with sufficiently high levels of uniformity for precise two-dimensional Raman mapping of surface bound monolayers. The ease of fabrication together with the high sensitivities and spatial resolution that can be achieved suggests an attractive route to SERS substrates for portable chemical warfare agent detection, environmental monitors, noninvasive imaging of biomolecules, and other applications. C1 [Baca, Alfred J.; Truong, Tu T.; Banks, Tony R.; Nuzzo, Ralph G.; Rogers, John A.] Univ Illinois, Beckman Inst, Fredrick Seitz Mat Res Lab, Dept Chem, Urbana, IL 61801 USA. [Cambrea, Lee R.] USN, Air Warfare Ctr, Weap Div, Dept Chem, China Lake, CA 93555 USA. [Montgomery, Jason M.; Gray, Stephen K.] Argonne Natl Lab, Ctr Nanoscale Mat, Argonne, IL 60439 USA. [Abdula, Daner; Yao, Jimin; Rogers, John A.] Univ Illinois, Dept Mat Sci & Engn, Urbana, IL 61801 USA. [Abdula, Daner; Yao, Jimin; Rogers, John A.] Univ Illinois, Dept Elect & Comp Engn, Urbana, IL 61801 USA. RP Baca, AJ (reprint author), Univ Illinois, Beckman Inst, Fredrick Seitz Mat Res Lab, Dept Chem, Urbana, IL 61801 USA. EM jrogers@illinois.edu RI Truong, Tu/E-7029-2011; Rogers, John /L-2798-2016; OI Abdula, Daner/0000-0002-5912-7482 FU U. S. Department of Energy (DoE), Division of Materials Sciences [DE-FG02-07ER46471]; NERSC [DE-AC02-05CH11231, DE-AC0206CH11357] FX A. J. B. thanks C. Conway and D. Stevenson and support from the SMART fellowship program. This work was supported by the U. S. Department of Energy (DoE), Division of Materials Sciences, Contract No. DE-FG02-07ER46471 and ONR ILIR program. Use of NERSC was supported by DOE Contract Nos. DE-AC02-05CH11231 and DE-AC0206CH11357. NR 14 TC 27 Z9 27 U1 3 U2 14 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUN 15 PY 2009 VL 94 IS 24 AR 243109 DI 10.1063/1.3155198 PG 3 WC Physics, Applied SC Physics GA 460DF UT WOS:000267166600066 ER PT J AU Phillips, CJ Matyas, GR Hansen, CJ Alving, CR Smith, TC Ryan, MAK AF Phillips, Christopher J. Matyas, Gary R. Hansen, Christian J. Alving, Carl R. Smith, Tyler C. Ryan, Margaret A. K. TI Antibodies to squalene in US Navy Persian Gulf War veterans with chronic multisymptom illness SO VACCINE LA English DT Article DE Immunologic adjuvants; Squalene; Anthrax vaccines ID DESERT-STORM; HEALTH; SYMPTOMS; EXPOSURE; INDUCTION; RESPONSES; ASSAY AB Since the end of the 1991 Gulf War, there have been reports of unexplained, multisymptom illnesses afflicting veterans who consistently report more symptoms than do nondeployed veterans. One of the many possible exposures suspected of causing chronic multisymptom illnesses Gulf War veterans is squalene, thought to be present in anthrax vaccine. We examined the relationship between squalene antibodies and chronic symptoms reported by Navy construction workers (Seabees), n = 579. 30.2% were deployers, 7.4% were defined as ill, and 43.5% were positive for squalene antibodies. We found no association between squalene antibody Status and chronic multisymptom illness (p = 0.465). The etiology of Gulf War syndrome remains unknown, but Should not include squalene antibody status. Published by Elsevier Ltd. C1 [Phillips, Christopher J.; Hansen, Christian J.; Smith, Tyler C.] USN, Hlth Res Ctr, US Dept Def, Ctr Deployment Hlth Res, San Diego, CA 92106 USA. [Matyas, Gary R.; Alving, Carl R.] Walter Reed Army Inst Res, Dept Adjuvant, Rockville, MD 20850 USA. [Matyas, Gary R.; Alving, Carl R.] Walter Reed Army Inst Res, Antigen Res Div Retrovirol, Rockville, MD 20850 USA. [Ryan, Margaret A. K.] Univ Calif San Diego, Div Epidemiol, Dept Family & Prevent Med, La Jolla, CA 92093 USA. RP Phillips, CJ (reprint author), USN, Hlth Res Ctr, US Dept Def, Ctr Deployment Hlth Res, 140 Sylvester Rd, San Diego, CA 92106 USA. EM chris.phillips@med.navy.mil OI Matyas, Gary/0000-0002-2074-2373 FU Naval Health Research Center [08-34]; Department of Defense [60002]; US Department of the Navy; US Department of the Army; US Department of the Air Force; US Department of Defense; federal regulations governing the protection of human subjects in research [NHRC.2002.0013] FX This represents Naval Health Research Center report 08-34, supported by the Department of Defense, under work unit No. 60002. Funding sources did not play any other role. The views expressed in this article are those of the authors and do not reflect the official policy or position of the US Department of the Navy, US Department of the Army, US Department of the Air Force, or US Department of Defense, approved for public release. This research has been conducted in compliance with all applicable federal regulations governing the protection of human subjects in research (Protocol NHRC.2002.0013). NR 41 TC 16 Z9 17 U1 2 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JUN 12 PY 2009 VL 27 IS 29 BP 3921 EP 3926 DI 10.1016/j.vaccine.2009.03.091 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 465KA UT WOS:000267581300017 PM 19379786 ER PT J AU Bukowinski, A Rockswold, P Smith, B Smith, T AF Bukowinski, A. Rockswold, P. Smith, B. Smith, T. TI GUILLAIN-BARRE SYNDROME IN US ACTIVE-DUTY MILITARY PERSONNEL SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 42nd Annual Meeting of the Society-for-Epidemiologic-Research CY JUN 23-26, 2009 CL Anaheim, CA SP Soc Epidemiol Res C1 [Bukowinski, A.; Rockswold, P.; Smith, B.; Smith, T.] Naval Hlth Res Ctr, San Diego, CA 92106 USA. RI Bukowinski, Anna/A-7273-2010 NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 2009 VL 169 BP S58 EP S58 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 456SK UT WOS:000266868300230 ER PT J AU Granado, N Smith, T Swanson, M Harris, R Shahar, E Smith, B Boyko, E Wells, T Ryan, M AF Granado, N. Smith, T. Swanson, M. Harris, R. Shahar, E. Smith, B. Boyko, E. Wells, T. Ryan, M. TI NEW-ONSET HYPERTENSION ASSOCIATED WITH COMBAT DEPLOYMENT IN MILLENNIUM COHORT ACTIVE-DUTY, RESERVE AND NATIONAL GUARD MEMBERS SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 42nd Annual Meeting of the Society-for-Epidemiologic-Research CY JUN 23-26, 2009 CL Anaheim, CA SP Soc Epidemiol Res C1 [Granado, N.; Smith, T.; Swanson, M.; Harris, R.; Shahar, E.; Smith, B.; Boyko, E.; Wells, T.; Ryan, M.] USN, Hlth Res Ctr, San Diego, CA 92103 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 2009 VL 169 BP S46 EP S46 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 456SK UT WOS:000266868300184 ER PT J AU Granado, N Smith, T Smith, B Koffman, R AF Granado, N. Smith, T. Smith, B. Koffman, R. TI MEETING THE MENTAL HEALTH NEEDS OF OUR DEPLOYING SERVICE MEMBERS: ASSESSMENT USING SELF-REPORTED SYMPTOM SCREEN AND ELECTRONIC MEDICAL ENCOUNTER DATA SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 42nd Annual Meeting of the Society-for-Epidemiologic-Research CY JUN 23-26, 2009 CL Anaheim, CA SP Soc Epidemiol Res C1 [Granado, N.; Smith, T.; Smith, B.; Koffman, R.] Naval Hlth Res Ctr, San Diego, CA 92106 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 2009 VL 169 BP S9 EP S9 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 456SK UT WOS:000266868300037 ER PT J AU Hooper, T Granado, N Gackstetter, G Scher, A Jankosky, C Boyko, E Smith, T AF Hooper, T. Granado, N. Gackstetter, G. Scher, A. Jankosky, C. Boyko, E. Smith, T. TI THE PREVALENCE OF MIGRAINE AND OTHER HEADACHE DISORDERS IN MILLENNIUM COHORT ACTIVE-DUTY, RESERVE AND NATIONAL GUARD MEMBERS. SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 42nd Annual Meeting of the Society-for-Epidemiologic-Research CY JUN 23-26, 2009 CL Anaheim, CA SP Soc Epidemiol Res C1 [Hooper, T.; Granado, N.; Gackstetter, G.; Scher, A.; Jankosky, C.; Boyko, E.; Smith, T.] USN, Hlth Res Ctr, San Diego, CA 92106 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 2009 VL 169 BP S118 EP S118 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 456SK UT WOS:000266868300468 ER PT J AU Jacobson, IG LeardMann, CA Smith, TC Smith, B Wells, TS Boyko, EJ Ryan, MAK AF Jacobson, I. G. LeardMann, C. A. Smith, T. C. Smith, B. Wells, T. S. Boyko, E. J. Ryan, M. A. K. CA Millennium Cohort Study Team TI PROSPECTIVE ANALYSIS OF POSTTRAUMATIC STRESS DISORDER AND DEPRESSION AMONG MILITARY PROFESSIONAL CAREGIVERS DEPLOYED TO THE WARS IN IRAQ AND AFGHANISTAN SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 42nd Annual Meeting of the Society-for-Epidemiologic-Research CY JUN 23-26, 2009 CL Anaheim, CA SP Soc Epidemiol Res C1 [Jacobson, I. G.; LeardMann, C. A.; Smith, T. C.; Smith, B.; Wells, T. S.; Boyko, E. J.; Ryan, M. A. K.; Millennium Cohort Study Team] USN, Hlth Res Ctr, San Diego, CA 92106 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 2009 VL 169 BP S124 EP S124 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 456SK UT WOS:000266868300491 ER PT J AU Jacobson, IG Awong, C Smith, B Boyko, EJ Gackstetter, GD Smith, TC AF Jacobson, I. G. Awong, C. Smith, B. Boyko, E. J. Gackstetter, G. D. Smith, T. C. CA Millennium Cohort Study Team TI IS COMPLEMENTARY AND ALTERNATIVE MEDICINE USE ASSOCIATED WITH CHANGE IN BODY MASS INDEX IN A LARGE MILITARY COHORT? SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 42nd Annual Meeting of the Society-for-Epidemiologic-Research CY JUN 23-26, 2009 CL Anaheim, CA SP Soc Epidemiol Res C1 [Jacobson, I. G.; Awong, C.; Smith, B.; Boyko, E. J.; Gackstetter, G. D.; Smith, T. C.; Millennium Cohort Study Team] Naval Hlth Res Ctr, San Diego, CA 92106 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 2009 VL 169 BP S61 EP S61 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 456SK UT WOS:000266868300242 ER PT J AU Jacobson, IG Smith, TC LeardMann, CA Smith, B Ryan, MAK AF Jacobson, I. G. Smith, T. C. LeardMann, C. A. Smith, B. Ryan, M. A. K. TI POSTDEPLOYMENT HOSPITALIZATION EXPERIENCE OF SERVICE MEMBERS DEPLOYED IN SUPPORT OF THE WARS IN IRAQ AND AFGHANISTAN SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 42nd Annual Meeting of the Society-for-Epidemiologic-Research CY JUN 23-26, 2009 CL Anaheim, CA SP Soc Epidemiol Res C1 [Jacobson, I. G.; Smith, T. C.; LeardMann, C. A.; Smith, B.; Ryan, M. A. K.] USN, Hlth Res Ctr, San Diego, CA 92106 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 2009 VL 169 BP S46 EP S46 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 456SK UT WOS:000266868300183 ER PT J AU Kelton, ML LeardMann, CA Smith, B Boyko, EJ Wells, TS Littman, A Smith, TC AF Kelton, M. L. LeardMann, C. A. Smith, B. Boyko, E. J. Wells, T. S. Littman, A. Smith, T. C. CA Millennium Cohort Study Team TI PHYSICAL ACTIVITY IS ASSOCIATED WITH POSTTRAUMATIC STRESS DISORDER SYMPTOMS IN A LARGE, MILITARY COHORT SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 42nd Annual Meeting of the Society-for-Epidemiologic-Research CY JUN 23-26, 2009 CL Anaheim, CA SP Soc Epidemiol Res C1 [Kelton, M. L.; LeardMann, C. A.; Smith, B.; Boyko, E. J.; Wells, T. S.; Littman, A.; Smith, T. C.; Millennium Cohort Study Team] USN, Hlth Res Ctr, San Diego, CA 92106 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 2009 VL 169 BP S66 EP S66 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 456SK UT WOS:000266868300262 ER PT J AU LeardMann, CA Jacobson, IG Smith, B Wells, TS Boyko, EJ Ryan, MAK Smith, TC AF LeardMann, C. A. Jacobson, I. G. Smith, B. Wells, T. S. Boyko, E. J. Ryan, M. A. K. Smith, T. C. CA Millennium Cohort Study Team TI A PROSPECTIVE INVESTIGATION OF POSTTRAUMATIC STRESS DISORDER AND BODY WEIGHT IN A LARGE MILITARY COHORT SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 42nd Annual Meeting of the Society-for-Epidemiologic-Research CY JUN 23-26, 2009 CL Anaheim, CA SP Soc Epidemiol Res C1 [LeardMann, C. A.; Jacobson, I. G.; Smith, B.; Wells, T. S.; Boyko, E. J.; Ryan, M. A. K.; Smith, T. C.; Millennium Cohort Study Team] USN, Hlth Res Ctr, San Diego, CA 92106 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 2009 VL 169 BP S66 EP S66 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 456SK UT WOS:000266868300263 ER PT J AU Sandweiss, D Slymen, D LeardMann, C Smith, B White, M Hooper, T Gackstetter, G Amoroso, P Smith, T AF Sandweiss, D. Slymen, D. LeardMann, C. Smith, B. White, M. Hooper, T. Gackstetter, G. Amoroso, P. Smith, T. CA Millennium Cohort Study Team TI A PROSPECTIVE ANALYSIS OF THE EFFECTS OF PRE-INJURY PSYCHOLOGICAL STATUS ON THE PSYCHOLOGICAL IMPACT OF INJURY DURING DEPLOYMENT IN SUPPORT OF THE WARS IN IRAQ AND AFGHANISTAN SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 42nd Annual Meeting of the Society-for-Epidemiologic-Research CY JUN 23-26, 2009 CL Anaheim, CA SP Soc Epidemiol Res C1 [Sandweiss, D.; Slymen, D.; LeardMann, C.; Smith, B.; White, M.; Hooper, T.; Gackstetter, G.; Amoroso, P.; Smith, T.; Millennium Cohort Study Team] USN, Hlth Res Ctr, San Diego, CA 92106 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 2009 VL 169 BP S108 EP S108 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 456SK UT WOS:000266868300430 ER PT J AU Seelig, AD Jacobson, IG Smith, B Hooper, TI Boyko, EJ Gackstetter, GD Gehrman, P Macera, CA Smith, TC AF Seelig, A. D. Jacobson, I. G. Smith, B. Hooper, T. I. Boyko, E. J. Gackstetter, G. D. Gehrman, P. Macera, C. A. Smith, T. C. CA Millennium Cohort Study Team TI SLEEP PATTERNS BEFORE, DURING, AND AFTER MILITARY COMBAT DEPLOYMENT IN SUPPORT OF THE WARS IN IRAQ AND AFGHANISTAN SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 42nd Annual Meeting of the Society-for-Epidemiologic-Research CY JUN 23-26, 2009 CL Anaheim, CA SP Soc Epidemiol Res C1 [Seelig, A. D.; Jacobson, I. G.; Smith, B.; Hooper, T. I.; Boyko, E. J.; Gackstetter, G. D.; Gehrman, P.; Macera, C. A.; Smith, T. C.; Millennium Cohort Study Team] USN, Hlth Res Ctr, San Diego, CA 92106 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 2009 VL 169 BP S123 EP S123 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 456SK UT WOS:000266868300490 ER PT J AU Smith, B Wingard, D Ryan, M Slymen, D Macera, C Patterson, T AF Smith, B. Wingard, D. Ryan, M. Slymen, D. Macera, C. Patterson, T. CA Millennium Cohort Study Team TI THE ASSOCIATION OF FREQUENCY AND DURATION OF DEPLOYMENT AND FUNCTIONAL HEALTH AMONG SERVICE MEMBERS DEPLOYED IN SUPPORT OF THE WARS IN IRAQ AND AFGHANISTAN SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 42nd Annual Meeting of the Society-for-Epidemiologic-Research CY JUN 23-26, 2009 CL Anaheim, CA SP Soc Epidemiol Res C1 [Smith, B.; Wingard, D.; Ryan, M.; Slymen, D.; Macera, C.; Patterson, T.; Millennium Cohort Study Team] USN, Hlth Res Ctr, San Diego, CA 92106 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 2009 VL 169 BP S124 EP S124 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 456SK UT WOS:000266868300494 ER PT J AU Smith, B Wong, C Smith, T Ryan, M Boyko, E Gackstetter, G Gray, G AF Smith, B. Wong, C. Smith, T. Ryan, M. Boyko, E. Gackstetter, G. Gray, G. CA Millennium Cohort Study Team TI PROSPECTIVE INVESTIGATION OF NEW-ONSET RESPIRATORY ILLNESS AMONG DEPLOYED MILITARY PERSONNEL SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 42nd Annual Meeting of the Society-for-Epidemiologic-Research CY JUN 23-26, 2009 CL Anaheim, CA SP Soc Epidemiol Res C1 [Smith, B.; Wong, C.; Smith, T.; Ryan, M.; Boyko, E.; Gackstetter, G.; Gray, G.; Millennium Cohort Study Team] USN, Hlth Res Ctr, San Diego, CA 92106 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 2009 VL 169 BP S125 EP S125 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 456SK UT WOS:000266868300495 ER PT J AU Smith, B Boyko, E Jacobson, I Smith, T Hooper, T Amoroso, P Gackstetter, G Ryan, M Barrett-Connor, E AF Smith, B. Boyko, E. Jacobson, I. Smith, T. Hooper, T. Amoroso, P. Gackstetter, G. Ryan, M. Barrett-Connor, E. TI RISK FACTORS FOR INCIDENT DIABETES IN US MILITARY PARTICIPANTS OF THE MILLENNIUM COHORT STUDY SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 42nd Annual Meeting of the Society-for-Epidemiologic-Research CY JUN 23-26, 2009 CL Anaheim, CA SP Soc Epidemiol Res C1 [Smith, B.; Boyko, E.; Jacobson, I.; Smith, T.; Hooper, T.; Amoroso, P.; Gackstetter, G.; Ryan, M.; Barrett-Connor, E.] USN, Hlth Res Ctr, San Diego, CA 92106 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 2009 VL 169 BP S2 EP S2 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 456SK UT WOS:000266868300009 ER PT J AU Smith, B Hooper, T Gackstetter, G LeardMann, C Boyko, E Pearse, L Amoroso, P Smith, T AF Smith, Besa Hooper, Tomoko Gackstetter, Gary LeardMann, C. Boyko, E. Pearse, L. Amoroso, P. Smith, T. CA Millennium Cohort Study Team TI EARLY MORTALITY EXPERIENCE AND A COMPARISON OF DATA SOURCES USED FOR MORTALITY ASCERTAINMENT IN A LARGE MILITARY COHORT SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 42nd Annual Meeting of the Society-for-Epidemiologic-Research CY JUN 23-26, 2009 CL Anaheim, CA SP Soc Epidemiol Res C1 [Smith, Besa; Hooper, Tomoko; Gackstetter, Gary; LeardMann, C.; Boyko, E.; Pearse, L.; Amoroso, P.; Smith, T.; Millennium Cohort Study Team] USN, Hlth Res Ctr, San Diego, CA 92106 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 2009 VL 169 BP S108 EP S108 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 456SK UT WOS:000266868300429 ER PT J AU Smith, T Smith, B Jacobson, I LeardMann, C Welch, K Farnell, L AF Smith, T. Smith, B. Jacobson, I. LeardMann, C. Welch, K. Farnell, L. CA Millennium Cohort Study Team TI THE MILLENNIUM COHORT STUDY: A 21-YEAR CONTRIBUTION TO THE UNDERSTANDING OF MILITARY HEALTH SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 42nd Annual Meeting of the Society-for-Epidemiologic-Research CY JUN 23-26, 2009 CL Anaheim, CA SP Soc Epidemiol Res C1 [Smith, T.; Smith, B.; Jacobson, I.; LeardMann, C.; Welch, K.; Farnell, L.; Millennium Cohort Study Team] USN, Hlth Res Ctr, San Diego, CA 92106 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 2009 VL 169 BP S124 EP S124 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 456SK UT WOS:000266868300492 ER PT J AU Smith, T Wells, T Jacobson, I Smith, B LeardMann, C Hoge, C Blazer, D Ryan, M AF Smith, T. Wells, T. Jacobson, I. Smith, B. LeardMann, C. Hoge, C. Blazer, D. Ryan, M. CA Millennium Cohort Study Team TI PROSPECTIVE INVESTIGATION OF MENTAL HEALTH CHALLENGES AND COPING BEHAVIORS IN DEPLOYERS SUPPORTING THE WARS IN IRAQ AND AFGHANISTAN SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 42nd Annual Meeting of the Society-for-Epidemiologic-Research CY JUN 23-26, 2009 CL Anaheim, CA SP Soc Epidemiol Res C1 [Smith, T.; Wells, T.; Jacobson, I.; Smith, B.; LeardMann, C.; Hoge, C.; Blazer, D.; Ryan, M.; Millennium Cohort Study Team] Naval Hlth Res Ctr, San Diego, CA 92106 USA. RI Blazer II, Dan/D-6675-2012 NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 2009 VL 169 BP S63 EP S63 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 456SK UT WOS:000266868300248 ER PT J AU Wells, T LeardMann, C Fortuna, S Smith, B Smith, T Ryan, M Boyko, E Blazer, D AF Wells, T. LeardMann, C. Fortuna, S. Smith, B. Smith, T. Ryan, M. Boyko, E. Blazer, D. CA Millennium Cohort Study Team TI DEPRESSION IS PROSPECTIVELY ASSOCIATED WITH COMBAT DEPLOYMENT IN SUPPORT OF THE WARS IN IRAQ AND AFGHANISTAN SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 42nd Annual Meeting of the Society-for-Epidemiologic-Research CY JUN 23-26, 2009 CL Anaheim, CA SP Soc Epidemiol Res C1 [Wells, T.; LeardMann, C.; Fortuna, S.; Smith, B.; Smith, T.; Ryan, M.; Boyko, E.; Blazer, D.; Millennium Cohort Study Team] USN, Hlth Res Ctr, San Diego, CA 92106 USA. RI Blazer II, Dan/D-6675-2012 NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 2009 VL 169 BP S66 EP S66 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 456SK UT WOS:000266868300261 ER PT J AU Choi, SR Kowalik, RW Alexander, DJ Bansal, NP AF Choi, Sung R. Kowalik, Robert W. Alexander, Donald J. Bansal, Narottam P. TI Elevated-temperature stress rupture in interlaminar shear of a Hi-Nic SiC/SiC ceramic matrix composite SO COMPOSITES SCIENCE AND TECHNOLOGY LA English DT Article DE Ceramic matrix composite; Mechanical properties; MI SiC/SiC; Interlaminar shear; Life prediction; Stress rupture ID CRACK-GROWTH; STRENGTH; INPLANE AB Assessments of stress rupture in a gas-turbine grade, melt-infiltrated Hi-Nicalon (TM) SiC continuous fiber-reinforced SiC ceramic matrix composite (CMC) were made in interlaminar shear at 1316 degrees C in air. The composite exhibited appreciable life limiting behavior with a life susceptibility parameter of n(s) = 22-24, estimated based on a proposed phenomenological life prediction model together with experimental data. The phenomenological life model was in good agreement in prediction between the stress rupture and the constant stress-rate data, validating its appropriateness in describing the life limiting phenomenon of the CIVIC coupons subjected to interlaminar shear. The results of this work also indicated that the governing mechanism(s) associated with failure in interlaminar shear would have remained almost unchanged, regardless of the type of loading configurations, either in stress rupture or in constant stress rate. Published by Elsevier Ltd. C1 [Choi, Sung R.; Kowalik, Robert W.; Alexander, Donald J.] Naval Air Syst Command, Patuxent River, MD 20670 USA. [Bansal, Narottam P.] NASA, Glenn Res Ctr, Cleveland, OH 44135 USA. RP Choi, SR (reprint author), Naval Air Syst Command, 48066 Shaw Rd, Patuxent River, MD 20670 USA. EM sung.choil@navy.mil FU NAVAIR; Office of Naval Research FX The authors (NAVAIR) acknowledge Dr. D. Shifler and the Office of Naval Research for the support of this work. Some mechanical testing was conducted at the NASA Glenn, Cleveland, Ohio. NR 24 TC 11 Z9 11 U1 0 U2 15 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0266-3538 J9 COMPOS SCI TECHNOL JI Compos. Sci. Technol. PD JUN PY 2009 VL 69 IS 7-8 BP 890 EP 897 DI 10.1016/j.compscitech.2008.12.006 PG 8 WC Materials Science, Composites SC Materials Science GA 450DH UT WOS:000266380700003 ER PT J AU Faulkner, SD Kwon, YW Bartlett, S Rasmussen, EA AF Faulkner, S. D. Kwon, Y. W. Bartlett, S. Rasmussen, E. A. TI Study of composite joint strength with carbon nanotube reinforcement SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID FRACTURE-TOUGHNESS; LOAD-TRANSFER; INTERFACE AB In order to strengthen the interface of a composite scarf joint, this study investigated the benefits of using locally applied carbon nanotubes to reinforce a carbon fiber composite scarf joint. The effect of carbon nanotubes on enhancing the fracture toughness and interface strength was investigated by performing Mode I and Mode II fracture tests with and without carbon nanotubes applied locally at the joint interface. Furthermore, the effects of seawater absorption and different carbon nanotube concentration values on Mode II fracture were investigated. Finally, a partial application of carbon nanotubes only near the crack tip area was considered. During the study, the image correlation technique was used to examine the fracture mechanisms altered by the introduction of carbon nanotubes. The experimental study showed that an optimal amount of carbon nanotubes could increase the fracture toughness of the composite joint interface significantly, especially for Mode II, including a physical change in the fracture mechanism. C1 [Faulkner, S. D.; Kwon, Y. W.] Naval Postgrad Sch, Dept Mech & Aeronaut Engn, Monterey, CA USA. [Bartlett, S.; Rasmussen, E. A.] Naval Surface Warfare Ctr, Struct & Composite Div, Bethesda, MD USA. RP Kwon, YW (reprint author), Naval Postgrad Sch, Dept Mech & Aeronaut Engn, Monterey, CA USA. EM ywkwon@nps.edu NR 19 TC 13 Z9 13 U1 1 U2 10 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD JUN PY 2009 VL 44 IS 11 BP 2858 EP 2864 DI 10.1007/s10853-009-3378-y PG 7 WC Materials Science, Multidisciplinary SC Materials Science GA 434TZ UT WOS:000265298300018 ER PT J AU Taylor, MK Mujica-Parodi, LR Padilla, GA Markham, AE Potterat, EG Momen, N Sander, TC Larson, GE AF Taylor, Marcus K. Mujica-Parodi, Lilianne R. Padilla, Genieleah A. Markham, Amanda E. Potterat, Eric G. Momen, Nausheen Sander, Todd C. Larson, Gerald E. TI Behavioral Predictors of Acute Stress Symptoms During Intense Military Training SO JOURNAL OF TRAUMATIC STRESS LA English DT Article ID POSTTRAUMATIC-STRESS; UNCONTROLLABLE STRESS; PERFORMANCE; DISSOCIATION; SURVIVORS; SEVERITY; CORTISOL; HEALTH AB A better understanding of factors influencing human responses to acute stress is needed to enhance prevention and treatment of stress-related disorders. In the current study, the authors examined predictors of acute stress symptoms during intense military training in 35 men. In univariate and multivariate models, perceived stress, passive coping, and emotion-focused coping during daily living predicted acute stress symptoms in response to realistic survival training, whereas active coping and problem-focused coping did not. Baseline stress levels and coping styles, both of which may be modifiable, appear to play a fundamental role in the human response to acute uncontrollable stress. Additional research is needed to better elucidate the relative and interactive contributions of behavioral predictors of acute stress. C1 [Taylor, Marcus K.] Naval Aerosp Med Res Lab, Operat Stress & Resilience Program, Pensacola, FL 32508 USA. [Taylor, Marcus K.; Padilla, Genieleah A.; Markham, Amanda E.; Momen, Nausheen; Sander, Todd C.; Larson, Gerald E.] Naval Hlth Res Ctr, San Diego, CA USA. [Mujica-Parodi, Lilianne R.] SUNY Stony Brook, Dept Biomed Engn, Stony Brook, NY USA. [Potterat, Eric G.] Naval Special Warfare Ctr, San Diego, CA USA. RP Taylor, MK (reprint author), Naval Aerosp Med Res Lab, Operat Stress & Resilience Program, 280 Fred Bauer St, Pensacola, FL 32508 USA. EM marc.taylor@med.navy.mil OI Mujica-Parodi, Lilianne/0000-0002-3752-5519 NR 24 TC 13 Z9 13 U1 0 U2 1 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0894-9867 J9 J TRAUMA STRESS JI J. Trauma Stress PD JUN PY 2009 VL 22 IS 3 BP 212 EP 217 DI 10.1002/jts.20413 PG 6 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA 468JR UT WOS:000267814300007 PM 19479980 ER PT J AU Kennedy, RB Ovsyannikova, IG Pankratz, VS Vierkant, RA Jacobson, RM Ryan, MAK Poland, GA AF Kennedy, Richard B. Ovsyannikova, Inna G. Pankratz, V. Shane Vierkant, Robert A. Jacobson, Robert M. Ryan, Margaret A. K. Poland, Gregory A. TI Gender effects on humoral immune responses to smallpox vaccine SO VACCINE LA English DT Article; Proceedings Paper CT 6th World Congress on Vaccines, Immunisation and Immunotherapy CY SEP 23-25, 2008 CL Milan, ITALY DE Smallpox vaccine; Vaccinia; Neutralizing antibody; Vaccine response ID POXVIRUS INFECTION; GENE POLYMORPHISMS; ETHNIC-DIFFERENCES; CELL MEMORY; ANTIBODY; RUBELLA; MEASLES; MUMPS; VIRUS; ASSOCIATIONS AB There are no data currently available on gender and racial variation in smallpox vaccine immune responses. We recruited 1076 healthy adults 18-40 years old who received one dose of the US-licensed smallpox vaccine (Dryvax (R)). Vaccinia neutralizing antibody titers in each Subject's serum were determined using a high throughput neutralization assay based on a recombinant, beta-gal expressing vaccinia virus. Results are reported as the serum dilution inhibiting 50% of virus activity (ID(50)). The median ID(50) for all subjects was 132.2 (inter-quartile range (IQR) = 78.8, 205.6). While no significant differences were observed with race and ethnicity, females had significantly higher neutralizing antibody titers than males (158.5 [93.2, 255.8] vs. 124.1 [75.2, 185.9]; p < 0.0001). As expected, time since vaccination was also associated with variations in neutralizing antibody titers in Our subjects. These data indicate that neutralizing antibody titers following primary smallpox vaccination Vary by gender. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Kennedy, Richard B.; Ovsyannikova, Inna G.; Jacobson, Robert M.; Poland, Gregory A.] Mayo Clin, Mayo Vaccine Res Grp, Rochester, MN 55905 USA. [Pankratz, V. Shane; Vierkant, Robert A.] Mayo Clin, Div Biostat, Rochester, MN 55905 USA. [Kennedy, Richard B.; Ovsyannikova, Inna G.; Poland, Gregory A.] Mayo Clin, Program Translat Immunovirol & Biodef, Rochester, MN 55905 USA. [Jacobson, Robert M.] Mayo Clin, Dept Pediat & Adolescent Med, Rochester, MN 55905 USA. [Ryan, Margaret A. K.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. RP Poland, GA (reprint author), Mayo Clin, Mayo Vaccine Res Grp, Guggenheim 611C,200 1st St SW, Rochester, MN 55905 USA. EM Poland.gregory@mayo.edu OI Vierkant, Robert/0000-0001-6242-5221; Jacobson, Robert/0000-0002-6355-8752 FU NCRR NIH HHS [1 UL1 RR024150-01, UL1 RR024150, UL1 RR024150-01]; NIAID NIH HHS [N01 AI040065, N01AI40065] NR 33 TC 33 Z9 33 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD MAY 26 PY 2009 VL 27 IS 25-26 BP 3319 EP 3323 DI 10.1016/j.vaccine.2009.01.086 PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 457QT UT WOS:000266947900016 PM 19200827 ER PT J AU Tate, JE Bunning, ML Lott, L Lu, XY Su, J Metzgar, D Brosch, L Panozzo, CA Marconi, VC Faix, DJ Prill, M Johnson, B Erdman, DD Fonseca, V Anderson, LJ Widdowson, MA AF Tate, Jacqueline E. Bunning, Michel L. Lott, Lisa Lu, Xiaoyan Su, John Metzgar, David Brosch, Lorie Panozzo, Catherine A. Marconi, Vincent C. Faix, Dennis J. Prill, Mila Johnson, Brian Erdman, Dean D. Fonseca, Vincent Anderson, Larry J. Widdowson, Marc-Alain TI Outbreak of Severe Respiratory Disease Associated with Emergent Human Adenovirus Serotype 14 at a US Air Force Training Facility in 2007 SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT 6th International Conference on Emerging Infectious Diseases CY MAR 16-19, 2008 CL Atlanta, GA ID MILITARY RECRUITS; YOUNG-ADULTS; LARGE EPIDEMIC; RISK-FACTORS; VIRUS WATCH; INFECTIONS; ILLNESS; SURVEILLANCE; TYPE-4; CHILDREN AB Background. In 2007, a US Air Force training facility reported a cluster of severe respiratory illnesses associated with a rare human adenovirus (Ad) serotype, Ad14. We investigated this outbreak to better understand its epidemiology, clinical spectrum, and associated risk factors. Methods. Data were collected from ongoing febrile respiratory illness (FRI) surveillance and from a retrospective cohort investigation. Because an Ad7 vaccine is in development, Ad7 antibody titers in pretraining serum samples from trainees with mild and those with severe Ad14 illness were compared. Results. During 2007, an estimated 551 (48%) of 1147 trainees with FRI were infected with Ad14; 23 were hospitalized with pneumonia, 4 required admission to an intensive care unit, and 1 died. Among cohort members (n = 173), the Ad14 infection rate was high (50%). Of those infected, 40% experienced FRI. Nocohort members were hospitalized. Male sex (risk ratio [RR], 4.7 [95% confidence interval {CI}, 2.2-10.1]) and an ill close contact (RR, 1.6 [95% CI, 1.2-2.2]) were associated with infection. Preexisting Ad7 neutralizing antibodies were found in 7 (37%) of 19 Ad14-positive trainees with mild illness but in 0 of 16 trainees with Ad14 pneumonia (P = .007). Conclusions. Emergence of Ad14, a rare Ad serotype, caused a protracted outbreak of respiratory illness among military recruits. Most infected recruits experienced FRI or milder illnesses. Some required hospitalization, and 1 died. Natural Ad7 infection may protect against severe Ad14 illness. C1 [Tate, Jacqueline E.; Lu, Xiaoyan; Panozzo, Catherine A.; Prill, Mila; Johnson, Brian; Erdman, Dean D.; Anderson, Larry J.; Widdowson, Marc-Alain] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA 30333 USA. [Su, John] Ctr Dis Control & Prevent, Off Workforce & Career Dev, Atlanta, GA 30333 USA. [Bunning, Michel L.; Brosch, Lorie] USAF, Med Grp 37, San Antonio, TX USA. [Lott, Lisa] Off AF Surg Gen, Modernizat Directorate, San Antonio, TX USA. [Marconi, Vincent C.] Wilford Hall USAF Med Ctr, Infect Dis Serv, San Antonio, TX 78236 USA. [Su, John; Fonseca, Vincent] Texas Dept State Hlth Serv, Austin, TX USA. [Metzgar, David; Faix, Dennis J.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. RP Tate, JE (reprint author), Ctr Dis Control & Prevent, Div Viral Dis, 1600 Clinton Rd NE,MS-A47, Atlanta, GA 30333 USA. EM jqt8@cdc.gov RI Valle, Ruben/A-7512-2013; Marconi, Vincent/N-3210-2014; OI Marconi, Vincent/0000-0001-8409-4689; Widdowson, Marc-Alain/0000-0002-0682-6933 NR 35 TC 65 Z9 66 U1 0 U2 3 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD MAY 15 PY 2009 VL 199 IS 10 BP 1419 EP 1426 DI 10.1086/598520 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 437TK UT WOS:000265509600003 PM 19351260 ER PT J AU Mullen, L Laux, A Cochenour, B AF Mullen, Linda Laux, Alan Cochenour, Brandon TI Propagation of modulated light in water: implications for imaging and communications systems SO APPLIED OPTICS LA English DT Article ID OPTICAL COMMUNICATION; UNDERWATER AB Until recently, little has been done to study the effect of higher modulation frequencies (> 100 MHz) or short (< 2 ns) pulse durations on forward-scattered light in ocean water. This forward-scattered light limits image resolution and may ultimately limit the bandwidth of a point-to-point optical communications link. The purpose of this work is to study the propagation of modulated light fields at frequencies up to 1 GHz. Results from laboratory tank experiments and their impact on future underwater optical imaging and communications systems are discussed. C1 [Mullen, Linda; Laux, Alan; Cochenour, Brandon] USN, Air Syst Command, Electroopt & Special Mission Sensors Div, NAVAIR, Patuxent River, MD 20670 USA. RP Mullen, L (reprint author), USN, Air Syst Command, Electroopt & Special Mission Sensors Div, NAVAIR, 22347 Cedar Point Rd, Patuxent River, MD 20670 USA. EM linda.mullen@navy.mil FU In-House Laboratory Innovative Research (ILIR) FX This work was funded by In-House Laboratory Innovative Research (ILIR) funds. NR 12 TC 36 Z9 38 U1 0 U2 11 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD MAY 10 PY 2009 VL 48 IS 14 BP 2607 EP 2612 DI 10.1364/AO.48.002607 PG 6 WC Optics SC Optics GA 451IV UT WOS:000266464800001 PM 19424378 ER EF