FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Zhang, BX Zhang, ZL Lin, AL Wang, HZ Pilia, M Ong, JL Dean, DD Chen, XD Yeh, CK AF Zhang, Bin-Xian Zhang, Zhi-Liang Lin, Alan L. Wang, Hanzhou Pilia, Marcello Ong, Joo L. Dean, David D. Chen, Xiao-Dong Yeh, Chih-Ko TI Silk Fibroin Scaffolds Promote Formation of the Ex Vivo Niche for Salivary Gland Epithelial Cell Growth, Matrix Formation, and Retention of Differentiated Function SO TISSUE ENGINEERING PART A LA English DT Article ID MESENCHYMAL STEM-CELLS; PAROTID ACINAR-CELLS; EXTRACELLULAR-MATRIX; BIOMEDICAL APPLICATIONS; STERILIZATION METHODS; BONE-MARROW; SECRETION; CULTURE; MORPHOGENESIS; FATE AB Salivary gland hypofunction often results from a number of causes, including the use of various medications, radiation for head and neck tumors, autoimmune diseases, diabetes, and aging. Since treatments for this condition are lacking and adult salivary glands have little regenerative capacity, there is a need for cell-based therapies to restore salivary gland function. Development of these treatment strategies requires the establishment of a system that is capable of replicating the salivary gland cell "niche" to support the proliferation and differentiation of salivary gland progenitor cells. In this study, a culture system using three-dimensional silk fibroin scaffolds (SFS) and primary salivary gland epithelial cells (pSGECs) from rat submandibular (SM) gland and parotid gland (PG) was established and characterized. pSGECs grown on SFS, but not tissue culture plastic (TCP), formed aggregates of cells with morphological features resembling secretory acini. High levels of amylase were released into the media by both cell types after extended periods in culture on SFS. Remarkably, cultures of PG-derived cells on SFS, but not SM cells, responded to isoproterenol, a beta-adrenergic receptor agonist, with increased enzyme release. This behavior mimics that of the salivary glands in vivo. Decellularized extracellular matrix (ECM) formed by pSGECs in culture on SFS contained type IV collagen, a major component of the basement membrane. These results demonstrate that pSGECs grown on SFS, but not TCP, retain important functional and structural features of differentiated salivary glands and produce an ECM that mimics the native salivary gland cell niche. These results demonstrate that SFS has potential as a scaffold for creating the salivary gland cell niche in vitro and may provide an approach for inducing multipotent stem cells to provide therapeutically meaningful numbers of salivary gland progenitor cells for regenerating these tissues in patients. C1 [Zhang, Bin-Xian; Yeh, Chih-Ko] South Texas Vet Hlth Care Syst, Geriatr Res Educ & Clin Ctr, Audie L Murphy Div, San Antonio, TX 78229 USA. [Zhang, Bin-Xian; Chen, Xiao-Dong] South Texas Vet Hlth Care Syst, Res Serv, Audie L Murphy Div, San Antonio, TX 78229 USA. [Zhang, Bin-Xian; Zhang, Zhi-Liang; Lin, Alan L.; Wang, Hanzhou; Dean, David D.; Chen, Xiao-Dong; Yeh, Chih-Ko] Univ Texas Hlth Sci Ctr San Antonio, Dept Comprehens Dent, San Antonio, TX 78229 USA. [Pilia, Marcello; Ong, Joo L.] Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX USA. RP Yeh, CK (reprint author), South Texas Vet Hlth Care Syst, Geriatr Res Educ & Clin Ctr 182, Audie L Murphy Div, 7400 Merton Minter Blvd, San Antonio, TX 78229 USA. EM chenx4@uthscsa.edu; yeh@uthscsa.edu OI Dean, David/0000-0002-4512-9065 FU NIH/NIDCR [R01 DE021084]; VA Merit Review grants [1I01BX001103, 1I01BX002145-01] FX This research was supported by grant R01 DE021084 from the NIH/NIDCR (Y. Sun and C.-K.Y.) and VA Merit Review grants 1I01BX001103 (C.-K.Y.) and 1I01BX002145-01 (X.-D.C.). The authors gratefully acknowledge the support from these organizations. NR 37 TC 6 Z9 6 U1 0 U2 5 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1937-3341 EI 1937-335X J9 TISSUE ENG PT A JI Tissue Eng. Part A PD MAY 1 PY 2015 VL 21 IS 9-10 BP 1611 EP 1620 DI 10.1089/ten.tea.2014.0411 PG 10 WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology SC Cell Biology; Biotechnology & Applied Microbiology GA CH3TD UT WOS:000353952300013 PM 25625623 ER PT J AU Simpson, TL Malte, CA Dietel, B Tell, D Pocock, I Lyons, R Varon, D Raskind, M Saxon, AJ AF Simpson, Tracy L. Malte, Carol A. Dietel, Bergetta Tell, Dana Pocock, Ian Lyons, Robert Varon, Dana Raskind, Murray Saxon, Andrew J. TI A Pilot Trial of Prazosin, an Alpha-1 Adrenergic Antagonist, for Comorbid Alcohol Dependence and Posttraumatic Stress Disorder SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH LA English DT Article DE Noradrenergic; Prazosin; Alcohol Dependence; Posttraumatic Stress Disorder; Human Clinical Trial ID RANDOMIZED CONTROLLED-TRIAL; SUBSTANCE USE DISORDER; PHARMACOLOGICAL-TREATMENT; PREFRONTAL CORTEX; RECENT PROGRESS; PTSD; NOREPINEPHRINE; INDIVIDUALS; NALTREXONE; VETERANS AB BackgroundPosttraumatic stress disorder (PTSD) and alcohol dependence (AD) commonly co-occur and are associated with greater symptom severity and costs than either disorder alone. No pharmacologic interventions have been found to decrease both alcohol use and PTSD symptom severity relative to matched placebo. Prazosin, an alpha-1 adrenoreceptor antagonist, has demonstrated the efficacy of reducing PTSD and AD symptoms among individuals with one or the other disorder and may be useful in addressing comorbid PTSD/AD. MethodsPrazosin and matched placebo were compared in the context of an outpatient 6-week double-blind randomized controlled pilot trial involving 30 individuals with comorbid PTSD/AD. Medication was titrated to 4mgqam, 4mgqpm and 8mg qhs by the end of week 2. Participants in both conditions received 5 medical management sessions. Information regarding alcohol use, craving, and PTSD was gathered daily using a telephone interactive voice response system. ResultsParticipants randomized to prazosin had a greater reduction in percent days drinking per week and percent days heavy drinking per week between baseline and week 6 than did placebo participants. No significant differences were detected within or between groups in change from weeks 1 to 6 in total PTSD symptoms. Participants in the prazosin condition reported drowsiness on significantly more days than those in the placebo condition. ConclusionsConsistent with the extant research evaluating medications for comorbid PTSD/AD, the current evaluation of prazosin also found decreased alcohol consumption but no medication effect on PTSD symptomatology. C1 [Simpson, Tracy L.; Malte, Carol A.; Dietel, Bergetta; Tell, Dana; Pocock, Ian; Lyons, Robert; Varon, Dana; Saxon, Andrew J.] VA Puget Sound Hlth Care Syst, Ctr Excellence Subst Abuse Treatment & Educ, Seattle, WA USA. [Simpson, Tracy L.; Raskind, Murray] VA Puget Sound Hlth Care Syst, Mental Illness Res Educ & Clin Ctr, Seattle, WA USA. [Simpson, Tracy L.; Raskind, Murray; Saxon, Andrew J.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [Dietel, Bergetta; Tell, Dana; Pocock, Ian; Lyons, Robert; Varon, Dana] Seattle Inst Biomed & Clin Res, Seattle, WA USA. RP Simpson, TL (reprint author), 1660 S Columbian Way,116 ATC S, Seattle, WA 98108 USA. EM Tracy.Simpson@va.gov FU VA Puget Sound Health Care System, Seattle, Washington Center of Excellence in Substance Abuse Treatment and Education; [NIAAA P20 1 P20 AA017839-01] FX Funding for this study was provided by a grant awarded to AJS (NIAAA P20 1 P20 AA017839-01) and the VA Puget Sound Health Care System, Seattle, Washington Center of Excellence in Substance Abuse Treatment and Education. NR 49 TC 12 Z9 12 U1 0 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0145-6008 EI 1530-0277 J9 ALCOHOL CLIN EXP RES JI Alcoholism (NY) PD MAY PY 2015 VL 39 IS 5 BP 808 EP 817 DI 10.1111/acer.12703 PG 10 WC Substance Abuse SC Substance Abuse GA CG1QX UT WOS:000353049600006 PM 25827659 ER PT J AU Cheng, R Chan, AP Ehdaie, A Bersohn, MM AF Cheng, Richard Chan, Amy P. Ehdaie, Ashkan Bersohn, Malcolm M. TI Heeding the Sign: Macroscopic T-Wave Alternans SO AMERICAN JOURNAL OF MEDICINE LA English DT Editorial Material C1 [Cheng, Richard; Chan, Amy P.; Ehdaie, Ashkan] Cedars Sinai Heart Inst, Los Angeles, CA USA. [Chan, Amy P.; Ehdaie, Ashkan; Bersohn, Malcolm M.] Univ Calif Los Angeles, Vet Affairs Greater Los Angeles Healthcare Syst, Div Cardiol, Los Angeles, CA 90073 USA. [Bersohn, Malcolm M.] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90073 USA. RP Bersohn, MM (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, VA Greater Los Angeles Healthcare Syst, Cardiol 111E,11301 Wilshire Blvd, Los Angeles, CA 90073 USA. EM mbersohn@ucla.edu OI Cheng, Richard/0000-0003-2552-6773 NR 5 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9343 EI 1555-7162 J9 AM J MED JI Am. J. Med. PD MAY PY 2015 VL 128 IS 5 BP 480 EP 483 DI 10.1016/j.amjmed.2015.01.006 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA CG7XK UT WOS:000353520500025 PM 25637757 ER PT J AU Minor, KS Friedman-Yakoobian, M Leung, YJ Meyer, EC Zimmet, SV Caplan, B Monteleone, T Bryant, C Guyer, M Keshavan, MS Seidman, LJ AF Minor, Kyle S. Friedman-Yakoobian, Michelle Leung, Y. Jude Meyer, Eric C. Zimmet, Suzanna V. Caplan, Brina Monteleone, Thomas Bryant, Caitlin Guyer, Margaret Keshavan, Matcheri S. Seidman, Larry J. TI The impact of premorbid adjustment, neurocognition, and depression on social and role functioning in patients in an early psychosis treatment program SO AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY LA English DT Article DE depression; early psychosis; premorbid adjustment; role functioning; social functioning ID QUALITY-OF-LIFE; 1ST-EPISODE NONAFFECTIVE PSYCHOSIS; 1ST EPISODE PSYCHOSIS; 10-YEAR FOLLOW-UP; NEGATIVE SYMPTOMS; HIGH-RISK; SCHIZOPHRENIA; PREDICTORS; RECOVERY; SCALE AB Objective: Functional impairments are debilitating concomitants of psychotic disorders and are present early in the illness course and, commonly, prior to psychosis onset. The factors affecting social and role functioning in early psychosis (EP) following treatment are unclear. We evaluated whether six months of participation in the PREPR, Boston, EP treatment program, part of a public-academic community mental health center, was related to improvements in social and role functioning and whether premorbid adjustment in adolescence, baseline neurocognition, and depression symptoms predicted functional improvement. Method: The Global Functioning Social and Role scales, MATRICS neurocognitive battery, and Calgary Depression Scale were assessed at baseline and six months during naturalistic treatment, while premorbid adjustment was measured at baseline. All participants were psychotic disorder patients in PREPR (n = 46 with social functioning and 47 with role functioning measures at both time points). Results: Large improvements were observed in role functioning (d = 0.84) and medium to large improvements were observed in social functioning (d = 0.70). Models consisting of adolescent premorbid adjustment and change in depression symptoms predicted social and role functioning change, whereas neuropsychological functioning did not. Conclusions: Substantial improvements in social and role functioning were observed among this sample participating in a recovery-based EP program. The impact of clinical factors on social and role functioning was highlighted. Further studies of premorbid adjustment in adolescence and the treatment of depression in EP programs in controlled treatment trials are needed to confirm these findings. C1 [Minor, Kyle S.] Indiana Univ Purdue Univ, Dept Psychol, Indianapolis, IN 46202 USA. [Friedman-Yakoobian, Michelle; Zimmet, Suzanna V.; Keshavan, Matcheri S.; Seidman, Larry J.] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA. [Friedman-Yakoobian, Michelle; Leung, Y. Jude; Zimmet, Suzanna V.; Monteleone, Thomas; Bryant, Caitlin; Guyer, Margaret; Keshavan, Matcheri S.; Seidman, Larry J.] Beth Israel Deaconess Med Ctr, Massachusetts Mental Hlth Ctr, Div Publ Psychiat, Boston, MA 02215 USA. [Meyer, Eric C.] US Dept Vet Affairs, VISN Ctr Excellence Res Returning War Vet 17, Waco, TX USA. [Meyer, Eric C.] Cent Texas Vet Healthcare Syst, Temple, TX USA. [Monteleone, Thomas; Guyer, Margaret] Massachusetts Mental Hlth Ctr, Dept Mental Hlth, Boston, MA 02115 USA. RP Minor, KS (reprint author), Indiana Univ Purdue Univ, Dept Psychol, 402 N Blackford,LD120C, Indianapolis, IN 46202 USA. EM ksminor@iupui.edu FU Commonwealth of Massachusetts [SCDMH82101008006]; Sidney R. Baer Jr. Foundation FX This work was supported in part by The Commonwealth of Massachusetts (SCDMH82101008006, L.J.S.) and the Sidney R. Baer Jr. Foundation (L.J.S.). NR 50 TC 3 Z9 3 U1 2 U2 8 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0004-8674 EI 1440-1614 J9 AUST NZ J PSYCHIAT JI Aust. N. Z. J. Psych. PD MAY PY 2015 VL 49 IS 5 BP 444 EP 452 DI 10.1177/0004867414565473 PG 9 WC Psychiatry SC Psychiatry GA CG3YC UT WOS:000353214700007 PM 25586755 ER PT J AU Melton, DW McManus, LM Gelfond, JAL Shireman, PK AF Melton, David W. McManus, Linda M. Gelfond, Jonathan A. L. Shireman, Paula K. TI Temporal phenotypic features distinguish polarized macrophages in vitro SO AUTOIMMUNITY LA English DT Article DE Chemokine; cytokine; macrophage; polarization; temporal ID ALTERNATIVELY ACTIVATED MACROPHAGES; TUMOR-ASSOCIATED MACROPHAGES; INDUCED MITOGENIC FACTOR; GENE-EXPRESSION; HUMAN MONOCYTES; GM-CSF; INTERFERON-GAMMA; IFN-GAMMA; INFLAMMATORY RESPONSE; CYTOKINE EXPRESSION AB Macrophages are important in vascular inflammation and environmental factors influence macrophage plasticity. Macrophage transitions into pro-inflammatory (M1) or anti-inflammatory (M2) states have been defined predominately by measuring cytokines in culture media (CM). However, temporal relationships between cellular and secreted cytokines have not been established. We measured phenotypic markers and cytokines in cellular and CM of murine bone marrow-derived macrophages at multiple time points following stimulation with IFN-gamma + LPS (M1), IL-4 (M2a) or IL-10 (M2c). Cytokines/proteins in M1-polarized macrophages exhibited two distinct temporal patterns; an early (0.5-3 h), transient increase in cellular cytokines (GM-CSF, KC-GRO, MIP-2, IP-10 and MIP-1 beta) and a delayed (3-6 h) response that was more sustained [IL-3, regulated on activation normal T cell expressed and secreted (RANTES), and tissue inhibitor of metalloproteinases 1 (TIMP-1)]. M2a-related cytokine/cell markers (IGF-1, Fizz1 and Ym1) were progressively (3-24 h) increased post-stimulation. In addition, novel patterns were observed. First, and unexpectedly, cellular pro-inflammatory chemokines, MCP-1 and MCP-3 but not MCP-5, were comparably increased in M1 and M2a macrophages. Second, Vegfr1 mRNA was decreased in M1 and increased in M2a macrophages. Finally, VEGF-A was increased in the CM of M1 cultures and strikingly reduced in M2a coinciding with increased Vegfr1 expression, suggesting decreased VEGF-A in M2a CM was secondary to increased soluble VEGFR1. In conclusion, macrophage cytokine production and marker expression were temporally regulated and relative levels compared across polarizing conditions were highly dependent upon the timing and location (cellular versus CM) of the sample collection. For most cytokines, cellular production preceded increases in the CM suggesting that cellular regulatory pathways should be studied within 6 h of stimulation. The divergent polarization-dependent expression of Vegfr1 may be essential to controlling VEGF potentially regulating angiogenesis and inflammatory cell infiltration in the vascular niche. The current study expands the repertoire of cytokines produced by polarized macrophages and provides insights into the dynamic regulation of macrophage polarization and resulting cytokines, proteins and gene expression that influence vascular inflammation. C1 [Melton, David W.; Shireman, Paula K.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA. [Melton, David W.] Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol, San Antonio, TX 78229 USA. [Melton, David W.; McManus, Linda M.; Gelfond, Jonathan A. L.; Shireman, Paula K.] Univ Texas Hlth Sci Ctr San Antonio, Sam & Ann Barshop Inst Longev & Aging Studies, San Antonio, TX 78229 USA. [McManus, Linda M.] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, San Antonio, TX 78229 USA. [Gelfond, Jonathan A. L.] Univ Texas Hlth Sci Ctr San Antonio, Dept Biostat & Epidemiol, San Antonio, TX 78229 USA. [Shireman, Paula K.] South Texas Vet Hlth Care Syst, San Antonio, TX USA. RP Shireman, PK (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, 7703 Floyd Curl Dr,MC 7741, San Antonio, TX 78229 USA. EM shireman@uthscsa.edu FU UTHSCSA; NIH-NCI [P30CA054174]; National Institutes of Health [HL074236, HL110743]; Veterans Administration Merit Review [1I01BX001186] FX We acknowledge the assistance of the UTHSCSA Genomics Core Shared Resource, which is supported by UTHSCSA and NIH-NCI P30CA054174 (CTRC of UTHSCSA).; The authors have no financial conflict of interest. These studies were supported, in part, by grants from the National Institutes of Health (HL074236 and HL110743), and the Veterans Administration Merit Review (1I01BX001186). NR 120 TC 7 Z9 8 U1 3 U2 8 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0891-6934 EI 1607-842X J9 AUTOIMMUNITY JI Autoimmunity PD MAY PY 2015 VL 48 IS 3 BP 161 EP 176 DI 10.3109/08916934.2015.1027816 PG 16 WC Immunology SC Immunology GA CG7YN UT WOS:000353523900004 PM 25826285 ER PT J AU Sonnenberg, A AF Sonnenberg, Amnon TI Adverse Outcomes: Why Bad Things Happen to Good People SO CLINICAL GASTROENTEROLOGY AND HEPATOLOGY LA English DT Editorial Material C1 [Sonnenberg, Amnon] Portland VA Med Ctr, Div Gastroenterol Hepatol, Portland, OR 97239 USA. [Sonnenberg, Amnon] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. RP Sonnenberg, A (reprint author), Portland VA Med Ctr, P3-GI,3710 SW US Vet Hosp Rd, Portland, OR 97239 USA. EM sonnenbe@ohsu.edu NR 9 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1542-3565 EI 1542-7714 J9 CLIN GASTROENTEROL H JI Clin. Gastroenterol. Hepatol. PD MAY PY 2015 VL 13 IS 5 BP 820 EP U295 DI 10.1016/j.cgh.2014.07.064 PG 5 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA CG1XN UT WOS:000353069000007 PM 25890669 ER PT J AU Singh, H Allen, JI AF Singh, Hardeep Allen, John I. TI Patient Safety Counterpoint: Systems Approaches and Multidisciplinary Strategies at the Centerpiece of Error Prevention SO CLINICAL GASTROENTEROLOGY AND HEPATOLOGY LA English DT Editorial Material ID COLORECTAL-CANCER DIAGNOSIS C1 [Singh, Hardeep] Baylor Coll Med, Michael E DeBakey Vet Affairs Med Ctr, Houston Vet Affairs Ctr Innovat Qual Effectivenes, Houston, TX 77030 USA. [Singh, Hardeep] Baylor Coll Med, Dept Med, Sect Hlth Serv Res, Houston, TX 77030 USA. [Allen, John I.] Yale Univ, Sch Med, New Haven, CT USA. RP Singh, H (reprint author), VA Med Ctr, Hlth Policy Qual & Informat Program, 152 2002 Holcombe Blvd, Houston, TX 77030 USA. EM hardeeps@bcm.edu FU AHRQ HHS [R01HS022087] NR 16 TC 2 Z9 2 U1 1 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1542-3565 EI 1542-7714 J9 CLIN GASTROENTEROL H JI Clin. Gastroenterol. Hepatol. PD MAY PY 2015 VL 13 IS 5 BP 824 EP 826 DI 10.1016/j.cgh.2015.01.005 PG 3 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA CG1XN UT WOS:000353069000008 PM 25890670 ER PT J AU Sosenko, JM Skyler, JS Beam, CA Boulware, D Mahon, JL Krischer, JP Greenbaum, CJ Rafkin, LE Matheson, D Herold, KC Palmer, JP AF Sosenko, Jay M. Skyler, Jay S. Beam, Craig A. Boulware, David Mahon, Jeffrey L. Krischer, Jeffrey P. Greenbaum, Carla J. Rafkin, Lisa E. Matheson, Della Herold, Kevan C. Palmer, Jerry P. CA Type 1 Diabet TrialNet Study Grp Diabet Prevention Trial-Type 1 TI The Development and Utility of a Novel Scale That Quantifies the Glycemic Progression Toward Type 1 Diabetes Over 6 Months SO DIABETES CARE LA English DT Article ID TRIAL-TYPE 1; C-PEPTIDE; NATURAL-HISTORY; GLUCOSE; DESIGN AB OBJECTIVEWe developed a scale to serve as a potential end point for 6-month glycemic progression (PS6M) toward type 1 diabetes (T1D) in autoantibody-positive relatives of individuals with T1D.RESEARCH DESIGN AND METHODSThe PS6M was developed from Diabetes Prevention Trial-Type 1 (DPT-1) data and tested in the TrialNet Pathway to Prevention Study (PTP). It is the difference between 6-month glucose sum values (30-120 min oral glucose tolerance test values) and values predicted for nonprogressors.RESULTSThe PS6M predicted T1D in the PTP (P < 0.001). The area under the receiver operating chacteristic curve was greater (P < 0.001) for the PS6M than for the baseline-to-6-month difference. PS6M values were higher in those with two or more autoantibodies, 30-0 min C-peptide values <2.00 ng/mL, or DPT-1 Risk Scores >7.00 (P < 0.001 for all).CONCLUSIONSThe PS6M is an indicator of short-term glycemic progression to T1D that could be a useful tool for assessing preventive treatments and biomarkers. C1 [Sosenko, Jay M.; Skyler, Jay S.; Rafkin, Lisa E.; Matheson, Della] Univ Miami, Div Endocrinol, Miami, FL 33124 USA. [Beam, Craig A.] Western Michigan Univ, Sch Med, Div Epidemiol & Biostat, Kalamazoo, MI 49008 USA. [Boulware, David; Krischer, Jeffrey P.] Univ S Florida, Div Informat & Biostat, Tampa, FL USA. [Mahon, Jeffrey L.] Univ Western Ontario, Dept Epidemiol & Biostat, London, ON, Canada. [Greenbaum, Carla J.] Benaroya Res Inst Virginia Mason, Seattle, WA USA. [Herold, Kevan C.] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT USA. [Palmer, Jerry P.] VA Puget Sound Hlth Care Syst, Seattle, WA USA. [Palmer, Jerry P.] Univ Washington, Div Endocrinol Metab & Nutr, Seattle, WA 98195 USA. RP Sosenko, JM (reprint author), Univ Miami, Div Endocrinol, Miami, FL 33124 USA. EM jsosenko@med.miami.edu RI Skyler, Jay/F-4211-2016 OI Tack, Jan/0000-0002-3206-6704 FU National Institutes of Health through the National Center for Research Resources; JDRF; American Diabetes Association FX This work was funded by the National Institutes of Health through the National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Allergy and Infectious Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Center for Research Resources, the JDRF, and the American Diabetes Association. NR 10 TC 4 Z9 4 U1 0 U2 5 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA SN 0149-5992 EI 1935-5548 J9 DIABETES CARE JI Diabetes Care PD MAY PY 2015 VL 38 IS 5 BP 940 EP 942 DI 10.2337/dc14-2787 PG 3 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA CG7SP UT WOS:000353505600040 PM 25758770 ER PT J AU Brima, W Eden, DJ Mehdi, SF Bravo, M Wiese, MM Stein, J Almonte, V Zhao, DZ Kurland, I Pessin, JE Zima, T Tanowitz, HB Weiss, LM Roth, J Nagajyothi, F AF Brima, Wunnie Eden, Daniel J. Mehdi, Syed Faizan Bravo, Michelle Wiese, Mohammad M. Stein, Joanna Almonte, Vanessa Zhao, Dazhi Kurland, Irwin Pessin, Jeffrey E. Zima, Tomas Tanowitz, Herbert B. Weiss, Louis M. Roth, Jesse Nagajyothi, Fnu TI The brighter (and evolutionarily older) face of the metabolic syndrome: evidence from Trypanosoma cruzi infection in CD-1 mice SO DIABETES-METABOLISM RESEARCH AND REVIEWS LA English DT Article DE metabolic syndrome; high-fat diet; Trypanosoma cruzi; metformin; infectious disease; mortality ID DENSITY-LIPOPROTEIN RECEPTOR; NECROSIS-FACTOR-ALPHA; CHAGAS-DISEASE; BRAZIL STRAIN; OBESITY; METFORMIN; CELLS; CARDIOMYOPATHY; TUBERCULOSIS; ASSOCIATION AB BackgroundInfection with Trypanosoma cruzi, the protozoan parasite that causes Chagas disease, results in chronic infection that leads to cardiomyopathy with increased mortality and morbidity in endemic regions. In a companion study, our group found that a high-fat diet (HFD) protected mice from T.cruzi-induced myocardial damage and significantly reduced post-infection mortality during acute T.cruzi infection. MethodsIn the present study metabolic syndrome was induced prior to T. cruzi infection by feeding a high fat diet. Also, mice were treated with anti-diabetic drug metformin. ResultsIn the present study, the lethality of T.cruzi (Brazil strain) infection in CD-1 mice was reduced from 55% to 20% by an 8-week pre-feeding of an HFD to induce obesity and metabolic syndrome. The addition of metformin reduced mortality to 3%. ConclusionsIt is an interesting observation that both the high fat diet and the metformin, which are known to differentially attenuate host metabolism, effectively modified mortality in T.cruzi-infected mice. In humans, the metabolic syndrome, as presently construed, produces immune activation and metabolic alterations that promote complications of obesity and diseases of later life, such as myocardial infarction, stroke, diabetes, Alzheimer's disease and cancer. Using an evolutionary approach, we hypothesized that for millions of years, the channeling of host resources into immune defences starting early in life ameliorated the effects of infectious diseases, especially chronic infections, such as tuberculosis and Chagas disease. In economically developed countries in recent times, with control of the common devastating infections, epidemic obesity and lengthening of lifespan, the dwindling benefits of the immune activation in the first half of life have been overshadowed by the explosion of the syndrome's negative effects in later life. Copyright (c) 2015 John Wiley & Sons, Ltd. C1 [Brima, Wunnie; Eden, Daniel J.; Mehdi, Syed Faizan; Bravo, Michelle; Wiese, Mohammad M.; Roth, Jesse] North Shore Long Isl Jewish Hlth Syst, Feinstein Inst Med Res, Lab Diabet & Diabet Related Res, Manhasset, NY USA. [Brima, Wunnie; Almonte, Vanessa; Zhao, Dazhi; Tanowitz, Herbert B.; Weiss, Louis M.; Roth, Jesse; Nagajyothi, Fnu] Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10461 USA. [Brima, Wunnie] Mt Sinai Med Ctr Hlth Syst, James J Peters VA Med Ctr, Bronx, NY USA. [Brima, Wunnie; Zima, Tomas] Charles Univ Prague, Prague, Czech Republic. [Stein, Joanna] North Shore Long Isl Jewish Hlth Syst, Feinstein Inst Med Res, Biostat Unit, Manhasset, NY USA. [Kurland, Irwin; Pessin, Jeffrey E.; Tanowitz, Herbert B.; Weiss, Louis M.] Albert Einstein Coll Med, Dept Med, Bronx, NY 10467 USA. [Roth, Jesse] North Shore Long Isl Jewish Hlth Syst, Hofstra North Shore LIJ Sch Med, Hempstead, NY USA. RP Roth, J (reprint author), 149-37 Powells Cove Blvd, Whitestone, NY 11357 USA. EM jesserothmd@hotmail.com; fnu.nagajyothi@einstein.yu.edu RI Zima, Tomas/F-6760-2017 OI Zima, Tomas/0000-0001-8518-6972 FU Feinstein Institute for Medical Research of the North Shore-Long Island Jewish Health System; Alan and Tatyana Forman Family; Russell Berrie Foundation; National Heart, Lung and Blood Institute (National Institutes of Health) [HL-112099] FX This study was supported by funds from the Feinstein Institute for Medical Research of the North Shore-Long Island Jewish Health System, the Alan and Tatyana Forman Family and the Russell Berrie Foundation. This work was also supported by grants from the National Heart, Lung and Blood Institute (National Institutes of Health HL-112099) to Fnu Nagajyothi. NR 40 TC 5 Z9 5 U1 2 U2 17 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1520-7560 J9 DIABETES-METAB RES JI Diabetes-Metab. Res. Rev. PD MAY PY 2015 VL 31 IS 4 BP 346 EP 359 DI 10.1002/dmrr.2636 PG 14 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA CG6GR UT WOS:000353396700004 PM 25613819 ER PT J AU Coletta, DK Fernandez, M Cersosimo, E Gastaldelli, A Musi, N DeFronzo, RA AF Coletta, D. K. Fernandez, M. Cersosimo, E. Gastaldelli, A. Musi, N. DeFronzo, R. A. TI The effect of muraglitazar on adiponectin signalling, mitochondrial function and fat oxidation genes in human skeletal muscle in vivo SO DIABETIC MEDICINE LA English DT Article ID TYPE-2 DIABETES-MELLITUS; ACTIVATED PROTEIN-KINASE; PLACEBO-CONTROLLED TRIAL; INSULIN SENSITIVITY; GLYCEMIC CONTROL; PPAR-GAMMA; PIOGLITAZONE; METABOLISM; RESISTANCE; RECEPTOR AB AimsThe molecular mechanisms by which muraglitazar (peroxisome proliferator-activated receptor / agonist) improves insulin sensitivity in Type2 diabetes mellitus are not fully understood. We hypothesized that muraglitazar would increase expression of 5-monophosphate-activated protein kinase and genes involved in adiponectin signalling, free fatty acid oxidation and mitochondrial function in skeletal muscle. MethodsSixteen participants with Type2 diabetes received muraglitazar, 5mg/day (n=12) or placebo (n=4). Before and after 16weeks, participants had vastus lateralis muscle biopsy followed by 180min euglycaemic hyperinsulinaemic clamp. ResultsMuraglitazar increased plasma adiponectin (9.01.1 to 17.81.5g/ml, P<0.05), while no significant change was observed with placebo. After 16weeks with muraglitazar, fasting plasma glucose declined by 31%, fasting plasma insulin decreased by 44%, insulin-stimulated glucose disposal increased by 81%, HbA(1c) decreased by 21% and plasma triglyceride decreased by 39% (all P<0.05). Muraglitazar increased mRNA levels of 5-monophosphate-activated protein kinase, adiponectin receptor1, adiponectin receptor2, peroxisome proliferator-activated receptor gamma coactivator-1 alpha and multiple genes involved in mitochondrial function and fat oxidation. In the placebo group, there were no significant changes in expression of these genes. ConclusionsMuraglitazar increases plasma adiponectin, stimulates muscle 5-monophosphate-activated protein kinase expression and increases expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation. These changes represent important cellular mechanisms by which dual peroxisome proliferator-activated receptor agonists improve skeletal muscle insulin sensitivity. What's new? Skeletal muscle insulin resistance is a characteristic feature of Type2 diabetes mellitus. Muraglitazar, a peroxisome proliferator-activated receptor / agonist augments insulin sensitivity, improves -cell function, mobilizes fat out of the liver and muscle, and improves dyslipidaemia. However, the molecular mechanisms by which muraglitazar exert its insulin-sensitizing effect remain unclear. This study demonstrates that muraglitazar increases plasma adiponectin levels and mRNA muscle expression of adiponectin receptors, 5-monophosphate-activated protein kinase and genes involved in mitochondrial function and fat oxidation. To our knowledge, no other study has investigated the molecular actions of muraglitazar in human skeletal muscle. C1 [Coletta, D. K.] Mayo Clin Arizona, Scottsdale, AZ USA. [Coletta, D. K.] Arizona State Univ, Sch Life Sci, Tempe, AZ USA. [Coletta, D. K.] Univ Arizona, Coll Med, Dept Basic Med Sci, Phoenix, AZ USA. [Fernandez, M.; Cersosimo, E.; Gastaldelli, A.; Musi, N.; DeFronzo, R. A.] Univ Texas Hlth Sci Ctr San Antonio, Diabet Div, San Antonio, TX 78229 USA. [Fernandez, M.; Cersosimo, E.; Musi, N.; DeFronzo, R. A.] Texas Diabet Inst, San Antonio, TX USA. [Gastaldelli, A.] CNR, Inst Clin Physiol, Pisa, Italy. [DeFronzo, R. A.] South Texas Vet Hlth Care Syst, San Antonio, TX USA. RP Coletta, DK (reprint author), Mayo Clin Arizona, Scottsdale, AZ USA. EM dawn.coletta@asu.edu RI Coletta, Dawn/G-6382-2016; Gastaldelli, Amalia/H-3319-2014 OI Gastaldelli, Amalia/0000-0003-2594-1651; Coletta, Dawn/0000-0001-5819-5152 FU Bristol Myers Squibb; Veterans Administration Service FX This work was supported by a research grant from Bristol Myers Squibb. Ralph A. DeFronzo's salary is supported by the Veterans Administration Service. NR 30 TC 1 Z9 2 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0742-3071 EI 1464-5491 J9 DIABETIC MED JI Diabetic Med. PD MAY PY 2015 VL 32 IS 5 BP 657 EP 664 DI 10.1111/dme.12664 PG 8 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA CG4BE UT WOS:000353224800013 PM 25484175 ER PT J AU Henry, KE Elfers, CT Burke, RM Chepurny, OG Holz, GG Blevins, JE Roth, CL Doyle, RP AF Henry, Kelly E. Elfers, Clinton T. Burke, Rachael M. Chepurny, Oleg G. Holz, George G. Blevins, James E. Roth, Christian L. Doyle, Robert P. TI Vitamin B-12 Conjugation of Peptide-YY3-36 Decreases Food Intake Compared to Native Peptide-YY3-36 Upon Subcutaneous Administration in Male Rats SO ENDOCRINOLOGY LA English DT Article ID GLUCAGON-LIKE PEPTIDE-1; C-FOS EXPRESSION; ORAL DELIVERY; BODY-WEIGHT; BRAIN-STEM; OBESE CHILDREN; RODENT MODELS; VAGUS NERVE; GUT HORMONE; YY3-36 AB Challenges to peptide-based therapies include rapid clearance, ready degradation by hydrolysis/proteolysis, and poor intestinal uptake and/or a need for blood brain barrier transport. This work evaluates the efficacy of conjugation of vitamin B-12 (B-12) on sc administered peptide tyrosine tyrosine (PYY)(3-36) function. In the current experiments, a B-12-PYY3-36 conjugate was tested against native PYY3-36, and an inactive conjugate B-12-PYYC36 (null control) in vitro and in vivo. In vitro experiments demonstrated similar agonism for the neuropeptide Y2 receptor by the B-12-PYY3-36 conjugate (EC50 26.5nM) comparedwith native PYY3-36(EC50 16.0 nM), with the null control having an EC50 of 1.8 mu M. In vivo experiments were performed in young adult male Sprague Dawley rats (9 wk). Daily treatments were delivered sc in five 1-hour pulses, each pulse delivering 5-10 nmol/kg, by implanted microinfusion pumps. Increases in hindbrain Fos expression were comparable 90 minutes after B-12-PYY3-36 or PYY3-36 injection relative to saline or B-12-PYYC36. Food intake was reduced during a 5-day treatment for both B-12-PYY3-36- (24%, P = .001) and PYY3-36-(13%, P = .008) treated groups relative to baseline. In addition, reduction of food intake after the three dark cycle treatment pulses was more consistent with B-12-PYY3-36 treatment (-26%, -29%, -27%) compared with the PYY3-36 treatment (-3%, -21%, -16%), and B-12-PYY3-36 generated a significantly longer inhibition of food intake vs PYY3-36 treatment after the first two pulses (P = .041 and P = .036, respectively). These findings demonstrate a stronger, more consistent, and longer inhibition of food intake after the pulses of B-12-PYY3-36 conjugate compared with the native PYY3-36. C1 [Henry, Kelly E.; Burke, Rachael M.; Doyle, Robert P.] Syracuse Univ, Ctr Sci & Technol, Dept Chem, Syracuse, NY 13244 USA. [Elfers, Clinton T.; Roth, Christian L.] Seattle Childrens Res Inst, Div Endocrinol, Ctr Integrat Brain Res, Seattle, WA 98101 USA. [Chepurny, Oleg G.; Holz, George G.; Doyle, Robert P.] SUNY Upstate Med Univ, Dept Med, Syracuse, NY 13210 USA. [Holz, George G.] SUNY Upstate Med Univ, Dept Pharmacol, Syracuse, NY 13210 USA. [Blevins, James E.] Vet Affairs Puget Sound Hlth Care Syst, Res & Dev Serv, Seattle, WA 98108 USA. [Blevins, James E.] Univ Washington, Dept Med, Div Metab Endocrinol & Nutr, Seattle, WA 98195 USA. [Roth, Christian L.] Univ Washington, Dept Pediat, Div Endocrinol, Seattle, WA 98105 USA. RP Doyle, RP (reprint author), Syracuse Univ, Ctr Sci & Technol, Dept Chem, 111 Coll Pl, Syracuse, NY 13244 USA. EM christian.roth@seattlechildrens.org; rpdoyle@syr.edu FU National Institute of Diabetes and Digestive and Kidney Diseases/National Institutes of Health/Department of Health and Human Services [NIH-R15DK097675-01A1]; Arnold and Mabel Beckman Foundation; Department of Veterans Affairs Merit Review Research Program; Research and Development Service of the Department of Veterans Affairs; Cellular and Molecular Imaging Core of the Diabetes Research Center at the University of Washington and National Institutes of Health [P30DK017047] FX This work was supported by the National Institute of Diabetes and Digestive and Kidney Diseases/National Institutes of Health/Department of Health and Human Services Grant NIH-R15DK097675-01A1 (to R.P.D. and C.L.R.), the Arnold and Mabel Beckman Foundation (to R.P.D.), and by the Department of Veterans Affairs Merit Review Research Program (to J.E.B.). Additional support included the Research and Development Service of the Department of Veterans Affairs and the Cellular and Molecular Imaging Core of the Diabetes Research Center at the University of Washington and National Institutes of Health Grant P30DK017047. NR 46 TC 5 Z9 5 U1 2 U2 9 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0013-7227 EI 1945-7170 J9 ENDOCRINOLOGY JI Endocrinology PD MAY PY 2015 VL 156 IS 5 BP 1739 EP 1749 DI 10.1210/en.2014-1825 PG 11 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA CG4RO UT WOS:000353274500016 PM 25658456 ER PT J AU New, AB Robin, DA Parkinson, AL Eickhoff, CR Reetz, K Hoffstaedter, F Mathys, C Sudmeyer, M Grefkes, C Larson, CR Ramig, LO Fox, PT Eickhoff, SB AF New, Anneliese B. Robin, Donald A. Parkinson, Amy L. Eickhoff, Claudia R. Reetz, Kathrin Hoffstaedter, Felix Mathys, Christian Sudmeyer, Martin Grefkes, Christian Larson, Charles R. Ramig, Loraine O. Fox, Peter T. Eickhoff, Simon B. TI The Intrinsic Resting State Voice Network in Parkinson's Disease SO HUMAN BRAIN MAPPING LA English DT Article DE Parkinson's disease; neuroimaging; resting-state; functional connectivity; voice network ID FUNCTIONAL CONNECTIVITY MRI; HUMAN AUDITORY-CORTEX; BRAIN ACTIVITY; BASAL GANGLIA; HEAD MOTION; SPEECH; NEUROANATOMY; STRIATUM; CIRCUITS; THALAMUS AB Over 90 percent of patients with Parkinson's disease experience speech-motor impairment, namely, hypokinetic dysarthria characterized by reduced pitch and loudness. Resting-state functional connectivity analysis of blood oxygen level-dependent functional magnetic resonance imaging is a useful measure of intrinsic neural functioning. We utilized resting-state functional connectivity modeling to analyze the intrinsic connectivity in patients with Parkinson's disease within a vocalization network defined by a previous meta-analysis of speech (Brown et al., 2009). Functional connectivity of this network was assessed in 56 patients with Parkinson's disease and 56 gender-, age-, and movement-matched healthy controls. We also had item 5 and 18 of the UPDRS, and the PDQ-39 Communication subscale available for correlation with the voice network connectivity strength in patients. The within-group analyses of connectivity patterns demonstrated a lack of subcortical-cortical connectivity in patients with Parkinson's disease. At the cortical level, we found robust (homotopic) interhemispheric connectivity but only inconsistent evidence for many intrahemispheric connections. When directly contrasted to the control group, we found a significant reduction of connections between the left thalamus and putamen, and cortical motor areas, as well as reduced right superior temporal gyrus connectivity. Furthermore, most symptom measures correlated with right putamen, left cerebellum, left superior temporal gyrus, right premotor, and left Rolandic operculum connectivity in the voice network. The results reflect the importance of (right) subcortical nodes and the superior temporal gyrus in Parkinson's disease, enhancing our understanding of the neurobiological underpinnings of vocalization impairment in Parkinson's disease. Hum Brain Mapp 36:1951-1962, 2015. (c) 2015 Wiley Periodicals, Inc. C1 [New, Anneliese B.; Robin, Donald A.; Parkinson, Amy L.; Fox, Peter T.] Univ Texas Hlth Sci Ctr San Antonio, Res Imaging Inst, San Antonio, TX 78229 USA. [Robin, Donald A.; Fox, Peter T.] Univ Texas Hlth Sci Ctr San Antonio, Dept Neurol, San Antonio, TX 78229 USA. [Robin, Donald A.; Fox, Peter T.] Univ Texas Hlth Sci Ctr San Antonio, Dept Radiol, San Antonio, TX 78229 USA. [Robin, Donald A.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Robin, Donald A.] Univ Texas San Antonio, Joint Program Biomed Engn, San Antonio, TX USA. [Eickhoff, Claudia R.; Hoffstaedter, Felix; Eickhoff, Simon B.] Univ Hosp, Res Ctr Julich, Inst Neurosci & Med INM 1, Dept Psychiat Psychotherapy & Psychosomat, Julich, Germany. [Eickhoff, Claudia R.] Univ Hosp Aachen, Dept Psychiat Psychotherapy & Psychosomat, Aachen, Germany. [Reetz, Kathrin] Univ Aachen, Dept Neurol, Aachen, Germany. [Reetz, Kathrin] Univ Hosp, Res Ctr Julich, Inst Neurosci & Med INM 4, Dept Neurol, Julich, Germany. [Reetz, Kathrin] Julich Aachen Res Alliance, Translat Brain Med, Julich, Germany. [Reetz, Kathrin] Julich Aachen Res Alliance, Translat Brain Med, Aachen, Germany. [Hoffstaedter, Felix; Eickhoff, Simon B.] Univ Dusseldorf, Dept Clin Neurosci & Med Psychol, Dusseldorf, Germany. [Mathys, Christian] Univ Dusseldorf, Fac Med, Dept Diagnost & Intervent Radiol, Dusseldorf, Germany. [Sudmeyer, Martin] Univ Dusseldorf, Dept Neurol, Univ Hosp, Dusseldorf, Germany. [Grefkes, Christian] Max Planck Inst Neurol Res Neuromodulat & Neurore, Cologne, Germany. [Grefkes, Christian] Univ Cologne, Dept Neurol, D-50931 Cologne, Germany. [Larson, Charles R.] Northwestern Univ, Commun Sci & Disorders, Evanston, IL USA. [Ramig, Loraine O.] Univ Colorado, Dept Speech Language & Hearing Sci, Boulder, CO 80309 USA. [Ramig, Loraine O.] Natl Ctr Voice & Speech, Salt Lake City, UT USA. [Fox, Peter T.] South Texas Vet Hlth Care Syst, Dept Neurol, San Antonio, TX USA. RP Robin, DA (reprint author), 8403 Floyd Curl Dr, San Antonio, TX 78229 USA. EM robind@uthscsa.edu RI Grefkes, Christian/H-3972-2013; Reetz, Kathrin/H-9510-2012 OI Reetz, Kathrin/0000-0002-9730-9228 FU National Institute of Health [R01DC001150-20, R01DC006243, R01-MH074457-01A1]; Excellence Initiative of the German federal government [DFG ZUK32/1]; Excellence Initiative of the German state government [DFG ZUK32/1]; Deutsche Forschungsgemeinschaft [GR 3285/2-1, GR 3285/5-1]; Helmholtz Initiative on systems biology; Human Brain Project; Deutsche Forschungsgemeinschaft (DFG) [EI 816/4-1, LA 3071/3-1] FX Contract grant sponsor: National Institute of Health; Contract grant numbers: R01DC001150-20, R01DC006243, and R01-MH074457-01A1; Contract grant sponsor: Excellence Initiative of the German federal and state governments; Contract grant number: DFG ZUK32/1(K.R.); Contract grant sponsor: Deutsche Forschungsgemeinschaft; Contract grant number: GR 3285/2-1 and GR 3285/5-1 (C.G.); Contract grant sponsor: Deutsche Forschungsgemeinschaft; Contract grant numbers: DFG, EI 816/4-1 and LA 3071/3-1 (S.B.E.); Contract grant sponsor: Helmholtz Initiative on systems biology and the Human Brain Project. NR 54 TC 8 Z9 8 U1 1 U2 16 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1065-9471 EI 1097-0193 J9 HUM BRAIN MAPP JI Hum. Brain Mapp. PD MAY PY 2015 VL 36 IS 5 BP 1951 EP 1962 DI 10.1002/hbm.22748 PG 12 WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA CG1XH UT WOS:000353068300023 PM 25627959 ER PT J AU Zhao, KW Murray, EJB Murray, SS AF Zhao, Ke-Wei Murray, Elsa J. Brochmann Murray, Samuel S. TI Spp24 Derivatives Stimulate a G(i)-Protein Coupled Receptor-Erk1/2 Signaling Pathway and Modulate Gene Expressions in W-20-17 Cells SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Article ID BONE MORPHOGENETIC PROTEIN-2; SECRETED PHOSPHOPROTEIN-24 KDA; BMP-BINDING PEPTIDE; RODENT MODEL; GROWTH; SEQUENCE; PHOSPHORYLATION; DIFFERENTIATION; INHIBITORS; CLEAVAGE AB Secreted phosphoprotein 24 kDa (Spp24) is an apatite-and BMP/TGF-beta cytokine-binding phosphoprotein found in serum and many tissues, including bone. N-terminally intact degradation products ranging in size from 14 kDa to 23 kDa have been found in bone. The cleavage sites in Spp24 that produce these short forms have not been definitively identified, and the biological activities and mechanisms of action of Spp24 and its degradation products have not been fully elucidated. We found that the C-terminus of Spp24 is labile to proteolysis by furin, kallikrein, lactoferrin, and trypsin, indicating that both extracellular and intracellular proteolytic events could account for the generation of biologically-active Spp18, Spp16, and Spp14. We determined the effects of these truncation products on kinase-mediated signal transduction, gene expression, and osteoblastic differentiation in W-20-17 bone marrow stromal cells cultured in basal or pro-osteogenic media. After culturing for five days, all forms inhibited BMP-2-stimulated osteoblastic differentiation, assessed as induction of alkaline phosphatase activity, in basal, but not pro-osteogenic media. After 10 days, they also inhibited BMP-2-stimulated mineral deposition in pro-osteogenic media. Spp24 had no effect on Erk1/2 phosphorylation, but Spp18 stimulated short-term Erk1/2, MEK 1/2, and p38 phosphorylation. Pertussis toxin and a MEK1/2 inhibitor ablated Spp18-stimulated Erk 1/2 phosphorylation, indicating a role for G(i) proteins and MEK1/2 in the Spp18-stimulated Erk1/2 phosphorylation cascade. Truncation products, but not full-length Spp24, stimulated RUNX2, ATF4, and CSF1 transcription. This suggests that Spp24 truncation products have effects on osteoblastic differentiation mediated by kinase pathways that are independent of exogenous BMP/TGF-b cytokines. J. Cell. Biochem. 116: 767-777, 2015. (C) 2014 Wiley Periodicals, Inc. C1 [Zhao, Ke-Wei; Murray, Elsa J. Brochmann; Murray, Samuel S.] Vet Affairs Greater Los Angeles Healthcare Syst, Geriatr Res Educ & Clin Ctr 11E, Sepulveda, CA 91343 USA. [Murray, Elsa J. Brochmann; Murray, Samuel S.] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90095 USA. [Murray, Samuel S.] Univ Calif Los Angeles, Interdept Program Biomed Engn, Los Angeles, CA 90095 USA. RP Murray, SS (reprint author), Vet Affairs Greater Los Angeles Healthcare Syst, Geriatr Res Educ & Clin Ctr 11E, Sepulveda, CA 91343 USA. EM Samuel.Murray@va.gov FU Department of Veterans Affairs Biomedical Laboratory [1I01BX000511]; Rehabilitation Research and Development Services [1I0RX000383] FX Supported by the Department of Veterans Affairs Biomedical Laboratory (1I01BX000511) and Rehabilitation (1I0RX000383) Research and Development Services. NR 46 TC 3 Z9 3 U1 0 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-2312 EI 1097-4644 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD MAY PY 2015 VL 116 IS 5 BP 767 EP 777 DI 10.1002/jcb.25032 PG 11 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA CF8ND UT WOS:000352817300009 PM 25501958 ER PT J AU Gorth, DJ Lothstein, KE Chiaro, JA Farrell, MJ Dodge, GR Elliott, DM Malhotra, NR Mauck, RL Smith, LJ AF Gorth, Deborah J. Lothstein, Katherine E. Chiaro, Joseph A. Farrell, Megan J. Dodge, George R. Elliott, Dawn M. Malhotra, Neil R. Mauck, Robert L. Smith, Lachlan J. TI Hypoxic Regulation of Functional Extracellular Matrix Elaboration by Nucleus Pulposus Cells in Long-Term Agarose Culture SO JOURNAL OF ORTHOPAEDIC RESEARCH LA English DT Article DE intervertebral disc; oxygen tension; extracellular matrix; mechanical properties; tissue engineering ID INTERVERTEBRAL DISC CELLS; BACK-PAIN; ANNULUS FIBROSUS; GENE-EXPRESSION; OXYGEN-TENSION; BLOOD-VESSELS; 3D SCAFFOLDS; IN-VITRO; DEGENERATION; METABOLISM AB Degeneration of the intervertebral discs is strongly implicated as a cause of low back pain. Since current treatments for discogenic low back pain show poor long-term efficacy, a number of new biological strategies are being pursued. For such therapies to succeed, it is critical that they be validated in conditions that mimic the unique biochemical microenvironment of the nucleus pulposus (NP), which include low oxygen tension. Therefore, the objective of this study was to investigate the effects of oxygen tension on NP cell functional extracellular matrix elaboration in 3D culture. Bovine NP cells were encapsulated in agarose constructs and cultured for 14 or 42 days in either 20% or 2% oxygen in defined media containing transforming growth factor beta-3. At each time point, extracellular matrix composition, biomechanics, and mRNA expression of key phenotypic markers were evaluated. Results showed that while bulk mechanics and composition were largely independent of oxygen level, low oxygen promoted improved restoration of the NP phenotype, higher mRNA expression of extracellular matrix and NP specific markers, and more uniform matrix elaboration. These findings indicate that culture under physiological oxygen levels is an important consideration for successful development of cell and growth factor-based regenerative strategies for the disc. (c) 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:747-754, 2015. C1 [Gorth, Deborah J.; Lothstein, Katherine E.; Chiaro, Joseph A.; Malhotra, Neil R.; Smith, Lachlan J.] Univ Penn, Dept Neurosurg, Philadelphia, PA 19104 USA. [Gorth, Deborah J.; Lothstein, Katherine E.; Chiaro, Joseph A.; Farrell, Megan J.; Dodge, George R.; Mauck, Robert L.; Smith, Lachlan J.] Univ Penn, Dept Orthopaed Surg, Philadelphia, PA 19104 USA. [Gorth, Deborah J.; Lothstein, Katherine E.; Chiaro, Joseph A.; Dodge, George R.; Mauck, Robert L.; Smith, Lachlan J.] Vet Affairs Med Ctr, Translat Musculoskeletal Res Ctr, Philadelphia, PA USA. [Elliott, Dawn M.] Univ Delaware, Dept Biomed Engn, Newark, DE USA. RP Smith, LJ (reprint author), Univ Penn, Dept Neurosurg, Philadelphia, PA 19104 USA. EM lachlans@mail.med.upenn.edu FU Department of Veterans Affairs [I01RX000211 I01RX001321]; National Institutes of Health [P30AR050950] FX Grant sponsor: Department of Veterans Affairs; Grant number: I01RX000211 I01RX001321; Grant sponsor: National Institutes of Health program; Grant number: P30AR050950. NR 39 TC 5 Z9 5 U1 2 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0736-0266 EI 1554-527X J9 J ORTHOP RES JI J. Orthop. Res. PD MAY PY 2015 VL 33 IS 5 BP 747 EP 754 DI 10.1002/jor.22821 PG 8 WC Orthopedics SC Orthopedics GA CG6NB UT WOS:000353417300018 PM 25640328 ER PT J AU Burke, RE Rooks, SP Levy, C Schwartz, R Ginde, AA AF Burke, Robert E. Rooks, Sean P. Levy, Cari Schwartz, Robert Ginde, Adit A. TI Identifying Potentially Preventable Emergency Department Visits by Nursing Home Residents in the United States SO Journal of the American Medical Directors Association LA English DT Article DE Preventable emergency visit; nursing home resident; emergency department utilization ID LONG-STAY RESIDENTS; AVOIDABLE HOSPITALIZATIONS; INAPPROPRIATE MEDICATIONS; COMMUNICATION; CONSEQUENCES; FACILITY; CRITERIA; ADULTS; RISK AB Objectives: To identify and describe potentially preventable emergency department (ED) visits by nursing home (NH) residents in the United States. These visits are important because they are common, frequently lead to hospitalization, and can be associated with significant cost to the patient and the health care system. Design: Retrospective analysis of the 2005-2010 National Hospital Ambulatory Care Survey (NHAMCS), comparing ED visits by nursing home residents that did not lead to hospital admission (potentially preventable) with those that led to admission (less likely preventable). Setting: Nationally representative sample of US EDs; federal hospitals and hospitals with fewer than 6 beds were excluded. Participants: Older (age >= 65 years) NH residents with an ED visit during this time period. Measurements: Patient demographics, ED visit information including testing performed, interventions (both procedures and medications) provided, and diagnoses treated. Results: Older NH residents accounted for 3857 of 208,956 ED visits during the time period of interest (1.8%). When weighted to be nationally representative, these represent 13.97 million ED visits, equivalent to 1.8 ED visits annually per NH resident in the United States. More than half of visits (53.5%) did not lead to hospital admission; of those discharged from the ED, 62.8% had normal vital signs on presentation and 18.9% did not have any diagnostic testing before ED discharge. Injuries were 1.78 times more likely to be discharged than admitted (44.8% versus 25.3%, respectively, P < .001), whereas infections were 2.06 times as likely to be admitted as discharged (22.9% versus 11.1%, respectively). Computed tomography (CT) scans were performed in 25.4% and 30.1% of older NH residents who were discharged from the ED and admitted to the hospital, respectively, and more than 70% of these were CTs of the head. NH residents received centrally acting, sedating medications before ED discharge in 9.4% of visits. Conclusion: This nationally representative sample of older NH residents suggests ED visits for injury, those that are associated with normal triage vital signs, and those that are not associated with any diagnostic testing are potentially preventable. Those discharged from the ED often undergo important testing and receive medications that may alter their physical examination on return to the nursing facility, highlighting the need for seamless communication of the ED course to NHs. Published by Elsevier Inc. on behalf of AMDA - The Society for Post-Acute and Long-Term Care Medicine. C1 [Burke, Robert E.] Eastern Colorado Hlth Care Syst, Dept Vet Affairs Med Ctr, Denver, CO USA. [Burke, Robert E.] Univ Colorado, Sch Med, Dept Med, Div Gen Internal Med, Denver, CO 80202 USA. [Rooks, Sean P.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio Sch Med, San Antonio, TX 78229 USA. [Levy, Cari] Univ Colorado, Sch Med, Div Hlth Care Policy & Res, Denver, CO USA. [Schwartz, Robert] Univ Colorado, Sch Med, Dept Med, Div Geriatr Med, Denver, CO 80202 USA. [Ginde, Adit A.] Univ Colorado, Sch Med, Dept Emergency Med, Denver, CO 80202 USA. RP Burke, RE (reprint author), Denver VA Med Ctr, 1055 Clermont St, Denver, CO 80220 USA. EM Robert.Burke5@va.gov RI bebarta, vikhyat/K-3476-2015; Siry, Bonnie/D-7189-2017 FU Colorado Clinical Translational Science Institute (National Institutes of Health [NIH]) [UL1 TR001082]; Department of Veterans Affairs Health Services Research and Development Service Center for Innovation: Value-Centered and Value-Driven Care; NIH [K23AG040708] FX R.E.B. and A.A.G. were supported by the Colorado Clinical Translational Science Institute (National Institutes of Health [NIH] UL1 TR001082) and R.E.B. and C.L. by the Department of Veterans Affairs Health Services Research and Development Service Center for Innovation: Value-Centered and Value-Driven Care. A.A.G. was supported by NIH grant K23AG040708. The sponsors had no role in the design, methods, analysis, or preparation of the manuscript. The views in this article are those of the authors and do not necessarily represent the views of the Department of Veterans Affairs or National Institute on Aging. NR 26 TC 10 Z9 10 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1525-8610 EI 1538-9375 J9 J AM MED DIR ASSOC JI J. Am. Med. Dir. Assoc. PD MAY 1 PY 2015 VL 16 IS 5 BP 395 EP 399 DI 10.1016/j.jamda.2015.01.076 PG 5 WC Geriatrics & Gerontology SC Geriatrics & Gerontology GA CG8IO UT WOS:000353551000008 PM 25703449 ER PT J AU Hildebrandt, E Ding, HT Mulky, A Dai, Q Aleksandrov, AA Bajrami, B Diego, PA Wu, X Ray, M Naren, AP Riordan, JR Yao, XD DeLucas, LJ Urbatsch, IL Kappes, JC AF Hildebrandt, Ellen Ding, Haitao Mulky, Alok Dai, Qun Aleksandrov, Andrei A. Bajrami, Bekim Diego, Pamela Ann Wu, Xing Ray, Marjorie Naren, Anjaparavanda P. Riordan, John R. Yao, Xudong DeLucas, Lawrence J. Urbatsch, Ina L. Kappes, John C. TI A Stable Human-Cell System Overexpressing Cystic Fibrosis Transmembrane Conductance Regulator Recombinant Protein at the Cell Surface SO MOLECULAR BIOTECHNOLOGY LA English DT Article DE CFTR; Mammalian cell; Overexpression; HEK293; Biophysical analysis ID ENGINEERED SUMO FUSIONS; LENTIVIRAL VECTOR; NUCLEOTIDE-BINDING; IN-VIVO; ENDOPLASMIC-RETICULUM; MASS-SPECTROMETRY; CHLORIDE CHANNEL; GENE DELIVERY; CFTR FUNCTION; EXPRESSION AB Recent human clinical trials results demonstrated successful treatment for certain genetic forms of cystic fibrosis (CF). To extend treatment opportunities to those afflicted with other genetic forms of CF disease, structural and biophysical characterization of CF transmembrane conductance regulator (CFTR) is urgently needed. In this study, CFTR was modified with various tags, including a His10 purification tag, the SUMOstar (SUMO*) domain, an extracellular FLAG epitope, and an enhanced green fluorescent protein (EGFP), each alone or in various combinations. Expressed in HEK293 cells, recombinant CFTR proteins underwent complex glycosylation, compartmentalized with the plasma membrane, and exhibited regulated chloride-channel activity with only modest alterations in channel conductance and gating kinetics. Surface CFTR expression level was enhanced by the presence of SUMO* on the N-terminus. Quantitative mass-spectrometric analysis indicated approximately 10 % of the total recombinant CFTR (SUMO*-CFTRFLAG-EGFP) localized to the plasma membrane. Trial purification using dodecylmaltoside for membrane protein extraction reproducibly recovered 178 +/- 56 mu g SUMO*-CFTRFLAG-EGFP per billion cells at 80 % purity. Fluorescence size-exclusion chromatography indicated purified CFTR was monodisperse. These findings demonstrate a stable mammalian cell expression system capable of producing human CFTR of sufficient quality and quantity to augment future CF drug discovery efforts, including biophysical and structural studies. C1 [Hildebrandt, Ellen; Urbatsch, Ina L.] Texas Tech Univ, Hlth Sci Ctr, Dept Cell Biol & Biochem, Lubbock, TX 79430 USA. [Hildebrandt, Ellen; Urbatsch, Ina L.] Texas Tech Univ, Hlth Sci Ctr, Ctr Membrane Prot Res, Lubbock, TX 79430 USA. [Ding, Haitao; Mulky, Alok; Dai, Qun; Wu, Xing; Kappes, John C.] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA. [Aleksandrov, Andrei A.; Riordan, John R.] Univ N Carolina, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA. [Bajrami, Bekim; Diego, Pamela Ann; Yao, Xudong] Univ Connecticut, Dept Chem, Storrs, CT 06269 USA. [Ray, Marjorie; DeLucas, Lawrence J.] Univ Alabama Birmingham, Dept Optometry, Birmingham, AL 35294 USA. [Naren, Anjaparavanda P.] Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA. [Kappes, John C.] Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA. [Kappes, John C.] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA. [Kappes, John C.] Birmingham Vet Affairs Med Ctr, Res Serv, Birmingham, AL 35233 USA. RP Urbatsch, IL (reprint author), Texas Tech Univ, Hlth Sci Ctr, Dept Cell Biol & Biochem, Lubbock, TX 79430 USA. EM ina.urbatsch@ttuhsc.edu; kappesjc@uab.edu FU Cystic Fibrosis Foundation [DELUCA03G0, URBATS13XX0, YAO07XX0]; National Institutes of Health [R01GM095639]; Virology, Genetic Sequencing and Flow Cytometry Cores of the UAB Center for AIDS Research [P30 AI27767]; UAB Rheumatic Diseases Core Center's High Resolution Imaging Facility [5P30 AR048311]; UAB CF Research & Translational Core Center [5P30 DK072482]; UAB Gregory Fleming James Cystic Fibrosis Research Center [464-CR07]; UAB Comprehensive Cancer Center Hybridoma Core FX This study was supported by the Cystic Fibrosis Foundation (DELUCA03G0, URBATS13XX0, and YAO07XX0) and the National Institutes of Health, including R01GM095639, the Virology, Genetic Sequencing and Flow Cytometry Cores of the UAB Center for AIDS Research (P30 AI27767), the UAB Rheumatic Diseases Core Center's High Resolution Imaging Facility (5P30 AR048311), and the UAB CF Research & Translational Core Center (5P30 DK072482). Support was also provided by the UAB Gregory Fleming James Cystic Fibrosis Research Center (464-CR07). The UAB Comprehensive Cancer Center Hybridoma Core supported the preparation of R1104 mAb ascites. P-glycoprotein-EGFP was a gift of D. Swartz, TTUHSC. The authors are grateful to J. Denise Wetzel, CCHMC Medical Writer, for editing of the manuscript. NR 61 TC 8 Z9 8 U1 2 U2 10 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA SN 1073-6085 EI 1559-0305 J9 MOL BIOTECHNOL JI Mol. Biotechnol. PD MAY PY 2015 VL 57 IS 5 BP 391 EP 405 DI 10.1007/s12033-014-9830-5 PG 15 WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology GA CG3AD UT WOS:000353147700001 PM 25577540 ER PT J AU Hildebrandt, E Ding, HT Mulky, A Dai, Q Aleksandrov, AA Bajrami, B Diego, PA Wu, X Ray, M Naren, AP Riordan, JR Yao, XD DeLucas, LJ Urbatsch, IL Kappes, JC AF Hildebrandt, Ellen Ding, Haitao Mulky, Alok Dai, Qun Aleksandrov, Andrei A. Bajrami, Bekim Diego, Pamela Ann Wu, Xing Ray, Marjorie Naren, Anjaparavanda P. Riordan, John R. Yao, Xudong DeLucas, Lawrence J. Urbatsch, Ina L. Kappes, John C. TI A Stable Human-Cell System Overexpressing Cystic Fibrosis Transmembrane Conductance Regulator Recombinant Protein at the Cell Surface (vol 57, pg 391, 2015) SO MOLECULAR BIOTECHNOLOGY LA English DT Correction C1 [Hildebrandt, Ellen; Urbatsch, Ina L.] Texas Tech Univ, Hlth Sci Ctr, Dept Cell Biol & Biochem, Lubbock, TX 79430 USA. [Hildebrandt, Ellen; Urbatsch, Ina L.] Texas Tech Univ, Hlth Sci Ctr, Ctr Membrane Prot Res, Lubbock, TX 79430 USA. [Ding, Haitao; Mulky, Alok; Dai, Qun; Wu, Xing; Kappes, John C.] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA. [Aleksandrov, Andrei A.; Riordan, John R.] Univ N Carolina, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA. [Bajrami, Bekim; Diego, Pamela Ann; Yao, Xudong] Univ Connecticut, Dept Chem, Storrs, CT 06269 USA. [Ray, Marjorie; DeLucas, Lawrence J.] Univ Alabama Birmingham, Dept Optometry, Birmingham, AL 35294 USA. [Naren, Anjaparavanda P.] Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA. [Kappes, John C.] Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA. [Kappes, John C.] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA. [Kappes, John C.] Birmingham Vet Affairs Med Ctr, Res Serv, Birmingham, AL 35233 USA. RP Urbatsch, IL (reprint author), Texas Tech Univ, Hlth Sci Ctr, Dept Cell Biol & Biochem, Lubbock, TX 79430 USA. EM ina.urbatsch@ttuhsc.edu; kappesjc@uab.edu FU NIDDK NIH HHS [P30 DK072482] NR 1 TC 1 Z9 1 U1 0 U2 0 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA SN 1073-6085 EI 1559-0305 J9 MOL BIOTECHNOL JI Mol. Biotechnol. PD MAY PY 2015 VL 57 IS 5 BP 406 EP 406 DI 10.1007/s12033-015-9857-2 PG 1 WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology GA CG3AD UT WOS:000353147700002 PM 25808031 ER PT J AU Thorpe, CT Johnson, H Dopp, AL Thorpe, JM Ronk, K Everett, CM Palta, M Mott, DA Chewning, B Schleiden, L Smith, MA AF Thorpe, Carolyn T. Johnson, Heather Dopp, Anna Legreid Thorpe, Joshua M. Ronk, Katie Everett, Christine M. Palta, Mari Mott, David A. Chewning, Betty Schleiden, Loren Smith, Maureen A. TI Medication oversupply in patients with diabetes SO Research in Social & Administrative Pharmacy LA English DT Article DE Refill adherence; Oversupply; Medication surplus; Diabetes ID HEALTH-CARE-SYSTEM; REFILL ADHERENCE; OLDER-ADULTS; REPEAT PRESCRIPTIONS; INSULIN THERAPY; COSTS; PERFORMANCE; HYPERTENSION; ASSOCIATION; CONTINUITY AB Background: Studies in integrated health systems suggest that patients often accumulate oversupplies of prescribed medications, which is associated with higher costs and hospitalization risk. However, predictors of oversupply are poorly understood, with no studies in Medicare Part D. Objective: The aim of this study was to describe prevalence and predictors of oversupply of antidiabetic, antihypertensive, and antihyperlipidemic medications in adults with diabetes managed by a large, multidisciplinary, academic physician group and enrolled in Medicare Part D or a local private health plan. Methods: This was a retrospective cohort study. Electronic health record data were linked to medical and pharmacy claims and enrollment data from Medicare and a local private payer for 2006-2008 to construct a patient-quarter dataset for patients managed by the physician group. Patients' quarterly refill adherence was calculated using ReComp, a continuous, multiple-interval measure of medication acquisition (CMA), and categorized as < 0.80 = Undersupply, 0.80-1.20 = Appropriate Supply, >1.20 = Oversupply. We examined associations of baseline and time-varying predisposing, enabling, and medical need factors to quarterly supply using multinomial logistic regression. Results: The sample included 2519 adults with diabetes. Relative to patients with private insurance, higher odds of oversupply were observed in patients aged ! 65 in Medicare (OR = 3.36, 95% CI = 1.61-6.99), patients 65+ in Medicare (OR = 2.51, 95% CI = 1.37-4.60), patients <65 in Medicare/Medicaid (OR = 4.55, 95% CI = 2.33-8.92), and patients 65+ in Medicare/Medicaid (OR = 5.73, 95% CI = 2.89-11.33). Other factors associated with higher odds of oversupply included any 90-day refills during the quarter, psychotic disorder diagnosis, and moderate versus tight glycemic control. Conclusions: Oversupply was less prevalent than in previous studies of integrated systems, but Medicare Part D enrollees had greater odds of oversupply than privately insured individuals. Future research should examine utilization management practices of Part D versus private health plans that may affect oversupply. Published by Elsevier Inc. C1 [Thorpe, Carolyn T.; Thorpe, Joshua M.] Vet Affairs Pittsburgh Healthcare Syst, Ctr Hlth Equ Res & Promot, Pittsburgh, PA 15240 USA. [Thorpe, Carolyn T.; Thorpe, Joshua M.; Schleiden, Loren] Univ Pittsburgh, Dept Pharm & Therapeut, Pittsburgh, PA 15260 USA. [Johnson, Heather] Univ Wisconsin, Dept Med, Madison, WI 53705 USA. [Dopp, Anna Legreid] Pharm Soc Wisconsin, Madison, WI 53717 USA. [Ronk, Katie; Palta, Mari; Smith, Maureen A.] Univ Wisconsin, Dept Populat Hlth Sci, Madison, WI 53705 USA. [Everett, Christine M.] Duke Univ, Med Ctr, Dept Community & Family Med, Durham, NC 27710 USA. [Mott, David A.; Chewning, Betty] Univ Wisconsin, Sch Pharm, Madison, WI 53705 USA. [Smith, Maureen A.] Univ Wisconsin, Dept Family Med, Madison, WI 53705 USA. [Smith, Maureen A.] Univ Wisconsin, Dept Surg, Madison, WI 53705 USA. RP Thorpe, CT (reprint author), Univ Pittsburgh, Sch Pharm, Dept Pharm & Therapeut, 919 Salk Hall,3501 Terrace St, Pittsburgh, PA 15260 USA. EM ctthorpe@pitt.edu FU AHRQ HHS [5T32HS000083, HS000083-12, R01 HS018368, R01HS018368, R21 HS017646, R21HS017646, T32 HS000083]; NCATS NIH HHS [9U54TR000021, UL1 TR000427]; NCRR NIH HHS [1UL1RR025011, UL1 RR025011]; NHLBI NIH HHS [K23 HL112907, 1K23HL112907]; NIDDK NIH HHS [R21 DK090634, R21DK090634]; None [HS000083-12] NR 46 TC 1 Z9 1 U1 1 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1551-7411 EI 1934-8150 J9 RES SOC ADMIN PHARM JI Res. Soc. Adm. Pharm. PD MAY-JUN PY 2015 VL 11 IS 3 BP 382 EP 400 DI 10.1016/j.sapharm.2014.09.002 PG 19 WC Public, Environmental & Occupational Health; Pharmacology & Pharmacy SC Public, Environmental & Occupational Health; Pharmacology & Pharmacy GA CG5KN UT WOS:000353330500013 PM 25288448 ER PT J AU Dichter, ME True, G AF Dichter, Melissa E. True, Gala TI "This Is the Story of Why My Military Career Ended Before It Should Have": Premature Separation From Military Service Among US Women Veterans SO AFFILIA-JOURNAL OF WOMEN AND SOCIAL WORK LA English DT Article DE gender-based violence; pregnancy; parenthood; qualitative; women veterans ID SEXUAL TRAUMA; CONSEQUENCES; AFGHANISTAN; PROPENSITY; IDENTITY; SOLDIERS; VIOLENCE; ENLIST; TIME; IRAQ AB Women who serve in the military benefit from unique opportunities but face strains as a minority population and, compared to men, report greater dissatisfaction with their service and have shorter military careers. We interviewed 35 U.S. women veterans about their decisions to enter and leave military service. Premature separationleaving military service before one plans, expects, or wants towas a prominent theme and was often precipitated by gender-based experiences, including interpersonal violence, harassment, and caregiving needs. Findings can inform efforts to improve the length and quality of women's military careers and support women during and after service. C1 [Dichter, Melissa E.; True, Gala] Philadelphia VA Med Ctr, Ctr Hlth Equ Res & Promot, Philadelphia, PA 19104 USA. [True, Gala] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA. RP Dichter, ME (reprint author), Philadelphia VA Med Ctr, Ctr Hlth Equ Res & Promot, 3900 Woodland Ave,Bldg 4100 Annex, Philadelphia, PA 19104 USA. EM mdichter@sp2.upenn.edu FU U.S. Department of Veterans Affairs, Health Services Research and Development Service (CDA) [10-202]; U.S. Department of Veterans Affairs, Center for Evaluation of Patient Aligned Care Teams ("IPV Assessment and Response with the PACT Model: Needs, Barriers, and Opportunities" CEPACT) [12-005]; U.S. Department of Veterans Affairs, Center for Health Equity Research and Promotion; U.S. Department of Veterans Affairs, Health Services Research and Development [10-255] FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Dr. Dichter is a Career Development awardee, supported by the U.S. Department of Veterans Affairs, Health Services Research and Development Service (CDA #10-202). This work was additionally supported by: U.S. Department of Veterans Affairs, Center for Evaluation of Patient Aligned Care Teams ("IPV Assessment and Response with the PACT Model: Needs, Barriers, and Opportunities," CEPACT #12-005, PI: Dichter); U.S. Department of Veterans Affairs, Center for Health Equity Research and Promotion ("Feasibility of a Life Story Intervention for OEF/OIF Veterans,'' PI: True); and U.S. Department of Veterans Affairs, Health Services Research and Development ("Photovoice as an educational intervention to improve care of OEF/OIF Veterans,'' PPO #10-255, PI: True) NR 33 TC 3 Z9 3 U1 1 U2 8 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0886-1099 EI 1552-3020 J9 AFFILIA J WOM SOC WO JI Affil. J. Women Soc. Work PD MAY PY 2015 VL 30 IS 2 BP 187 EP 199 DI 10.1177/0886109914555219 PG 13 WC Social Work; Women's Studies SC Social Work; Women's Studies GA CG1NV UT WOS:000353040800005 ER PT J AU Lu, ZY Li, YC Jin, JF Zhang, XM Hannun, YA Huang, Y AF Lu, Zhongyang Li, Yanchun Jin, Junfei Zhang, Xiaoming Hannun, Yusuf A. Huang, Yan TI GPR40/FFA1 and neutral sphingomyelinase are involved in palmitate-boosted inflammatory response of microvascular endothelial cells to LPS SO ATHEROSCLEROSIS LA English DT Article DE Atherosclerosis; Palmitic acid; LPS; Sphingolipid; Endothelium ID ACID RECEPTOR GPR40; INSULIN-RESISTANCE; CERAMIDE SYNTHESIS; BETA-CELLS; KEY ROLE; LIPOPOLYSACCHARIDE; ACTIVATION; APOPTOSIS; ATHEROSCLEROSIS; INTERLEUKIN-6 AB Objectives: Increased levels of both saturated fatty acids (SFAs) and lipopolysaccharide (LPS) are associated with type 2 diabetes. However, it remains largely unknown how SFAs interact with LPS to regulate inflammatory responses in microvascular endothelial cells (MIC ECs) that are critically involved in atherosclerosis as a diabetic complication. In this study, we compared the effects of LPS, palmitic acid (PA), the most abundant saturated fatty acid, or the combination of LPS and PA on interleukin (IL)-6 expression by MIC ECs and explored the underlying mechanisms. Methods: Human cardiac MIC ECs were treated with LPS, PA and LPS plus PA and the regulatory pathways including receptors, signal transduction, transcription and post-transcription, and sphingolipid metabolism for IL-6 expression were investigated. Results: G protein-coupled receptor (GPR) 40 or free fatty acid receptor 1 (FFA1), but not toll-like receptor 4, was involved in PA-stimulated IL-6 expression. PA not only stimulated IL-6 expression by itself, but also remarkably enhanced LPS-stimulated IL-6 expression via a cooperative stimulation on mitogen-activated protein kinase and nuclear factor kappa B signaling pathways, and both transcriptional and post-transcriptional activation. Furthermore, PA induced a robust neutral sphingomyelinase (nSMase)-mediated sphingomyelin hydrolysis that was involved in PA-augmented IL-6 upregulation. Conclusion: PA boosted inflammatory response of microvascular endothelial cells to LPS via GPR40 and nSMase. Published by Elsevier Ireland Ltd. C1 [Huang, Yan] Ralph H Johnson Vet Affairs Med Ctr, Charleston, SC 29401 USA. [Lu, Zhongyang; Li, Yanchun; Jin, Junfei; Zhang, Xiaoming; Huang, Yan] Med Univ S Carolina, Dept Med, Div Endocrinol Diabet & Med Genet, Charleston, SC 29425 USA. [Hannun, Yusuf A.] SUNY Stony Brook, Stony Brook Canc Ctr, Stony Brook, NY 11794 USA. [Jin, Junfei] Guilin Med Univ, Affiliated Hosp, Lab Hepatobiliary & Pancreat Surg, Guilin 541001, Guangxi, Peoples R China. RP Huang, Y (reprint author), Med Univ S Carolina, Div Endocrinol Diabet & Med Genet, 114 Doughty St, Charleston, SC 29425 USA. EM huangyan@musc.edu FU Biomedical Laboratory Research and Development Program of the Department of Veterans Affairs; NIH [DE016353, GM43825, CA97132]; Lipidomics Shared Resource, Hollings Cancer Center, Medical University of South Carolina [P30 CA138313]; Lipidomics Core in the SC Lipidomics and Pathobiology COBRE [P20 RR017677]; National Center for Research Resources; National Institutes of Health [C06 RR018823] FX This work was supported by the Biomedical Laboratory Research and Development Program of the Department of Veterans Affairs and NIH grant DE016353 (to Y.H.) and grants GM43825 and CA97132 (to Y.A.H.). The work on sphingolipid analysis was supported in part by the Lipidomics Shared Resource, Hollings Cancer Center, Medical University of South Carolina (P30 CA138313), the Lipidomics Core in the SC Lipidomics and Pathobiology COBRE (P20 RR017677) and the National Center for Research Resources and the Office of the Director of the National Institutes of Health through Grant Number C06 RR018823. NR 38 TC 5 Z9 5 U1 2 U2 14 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0021-9150 EI 1879-1484 J9 ATHEROSCLEROSIS JI Atherosclerosis PD MAY PY 2015 VL 240 IS 1 BP 163 EP 173 DI 10.1016/j.atherosclerosis.2015.03.013 PG 11 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA CF6YR UT WOS:000352703400027 PM 25795558 ER PT J AU Raskind, MA Peskind, ER Millard, S Petrie, EC AF Raskind, Murray A. Peskind, Elaine R. Millard, Steven Petrie, Eric C. TI Baseline Blood Pressure Is Associated with PTSD Symptom Response to Prazosin in Active Duty Combat Soldiers SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry on Stress, Emotion, Neurodevelopment and Psychopathology CY MAY 14-16, 2015 CL Toronto, CANADA SP Soc Biol Psychiat DE PTSD; prazosin; combat; soldiers C1 [Raskind, Murray A.; Peskind, Elaine R.; Millard, Steven; Petrie, Eric C.] VA Puget Sound Hlth Care Syst, Mental Illness Res Educ & Clin Ctr, Seattle, WA USA. NR 0 TC 0 Z9 0 U1 1 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0006-3223 EI 1873-2402 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD MAY 1 PY 2015 VL 77 IS 9 SU S MA 169 BP 63S EP 63S PG 1 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA CF0BM UT WOS:000352207500162 ER PT J AU Sahlem, GL Badran, BW Peyton, E Reeves, MT Halford, JJ Bachman, D Uhde, TW Borckardt, JJ George, MS AF Sahlem, Gregory L. Badran, Bashar W. Peyton, Emily Reeves, Matthew T. Halford, Jonathan J. Bachman, David Uhde, Thomas W. Borckardt, Jeffery J. George, Mark S. TI A Randomized Controlled Pilot Trial Suggesting that Cathodal Bi-frontal Transcranial Direct Current Stimulation (tDCS) May Shorten Sleep Onset Latency, and Increase Sleep Efficiency When Applied Before an Afternoon Nap. SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry on Stress, Emotion, Neurodevelopment and Psychopathology CY MAY 14-16, 2015 CL Toronto, CANADA SP Soc Biol Psychiat DE Transcranial Direct Current Stimulation; Sleep; tDCS C1 [Sahlem, Gregory L.; Badran, Bashar W.; Peyton, Emily; Reeves, Matthew T.; Uhde, Thomas W.; Borckardt, Jeffery J.; George, Mark S.] Med Univ S Carolina, Psychiat, Chrleston, SC USA. [Halford, Jonathan J.; Bachman, David] Med Univ S Carolina, Neurol, Chrleston, SC USA. [George, Mark S.] Ralph H Johnson VA Med Ctr, Psychiat, Charleston, SC USA. NR 0 TC 0 Z9 0 U1 3 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0006-3223 EI 1873-2402 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD MAY 1 PY 2015 VL 77 IS 9 SU S MA 326 BP 127S EP 127S PG 1 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA CF0BM UT WOS:000352207500319 ER PT J AU Austelle, CW Dowdle, LT DeVries, W Mithoefer, OJ Badran, BW George, MS Hanlon, CA AF Austelle, Christopher W. Dowdle, Logan T. DeVries, William Mithoefer, Oliver J. Badran, Bashar W. George, Mark S. Hanlon, Colleen A. TI To Crave or Not to Crave: Individual Variability in Alcohol Craving Is Associated with the Efficacy of TMS as a Treatment Tool for Alcoholism SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry on Stress, Emotion, Neurodevelopment and Psychopathology CY MAY 14-16, 2015 CL Toronto, CANADA SP Soc Biol Psychiat DE brain stimulation; addiction; neuroimaging; craving; theta burst C1 [Austelle, Christopher W.; Dowdle, Logan T.; DeVries, William; Mithoefer, Oliver J.; Badran, Bashar W.; George, Mark S.; Hanlon, Colleen A.] Med Univ S Carolina, Dept Psychiat, Charleston, SC 29425 USA. [Dowdle, Logan T.; George, Mark S.; Hanlon, Colleen A.] Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA. [George, Mark S.] Ralph H Johnson VA Med Ctr, Psychiat, Charleston, SC USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0006-3223 EI 1873-2402 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD MAY 1 PY 2015 VL 77 IS 9 SU S MA 329 BP 128S EP 128S PG 1 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA CF0BM UT WOS:000352207500322 ER PT J AU Siever, LJ McClure, M Graff, FA Hazlett, EA AF Siever, Larry J. McClure, Margaret Graff, Fiona A. Hazlett, Erin A. TI Guanfacine and Cognitive Remediation in the Schizophrenia Spectrum SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry on Stress, Emotion, Neurodevelopment and Psychopathology CY MAY 14-16, 2015 CL Toronto, CANADA SP Soc Biol Psychiat DE Guanfacine; Schizophrenia Spectrum; Cognitive Remediation; Social Cognition; Executive Function C1 [Siever, Larry J.; McClure, Margaret; Graff, Fiona A.; Hazlett, Erin A.] Icahn Sch Med Mt Sinai, James J Peters VAMC, Psychiat, New York, NY 10029 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0006-3223 EI 1873-2402 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD MAY 1 PY 2015 VL 77 IS 9 SU S MA 839 BP 301S EP 302S PG 2 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA CF0BM UT WOS:000352207502040 ER PT J AU Dowdle, LT Mithoefer, OJ George, MS Brown, TS Hanlon, CA AF Dowdle, Logan T. Mithoefer, Oliver J. George, Mark S. Brown, Truman S. Hanlon, Colleen A. TI Back To Basics: Robust Quantification of the TMS-associated Hemodynamic Response Function and Implications for TMS/BOLDFunctional Connectivity SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry on Stress, Emotion, Neurodevelopment and Psychopathology CY MAY 14-16, 2015 CL Toronto, CANADA SP Soc Biol Psychiat DE brain stimulation; functional connectivity; neuroimaging; prefrontal cortex; striatum C1 [Dowdle, Logan T.; Mithoefer, Oliver J.; George, Mark S.; Hanlon, Colleen A.] Med Univ S Carolina, Dept Psychiat, Charleston, SC 29425 USA. [Dowdle, Logan T.; George, Mark S.; Brown, Truman S.; Hanlon, Colleen A.] Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA. [George, Mark S.] Ralph H Johnson VA Med Ctr, Psychiat, Charleston, SC USA. [Brown, Truman S.] Med Univ S Carolina, Dept Radiol, Charleston, SC 29425 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0006-3223 EI 1873-2402 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD MAY 1 PY 2015 VL 77 IS 9 SU S MA 1031 BP 374S EP 374S PG 1 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA CF0BM UT WOS:000352207502224 ER PT J AU Messamore, E Dennis, LE AF Messamore, Erik Dennis, Laura E. TI Prevalence and Characterization of the Abnormal Niacin Response among Subjects with Schizophrenia and First-Degree Relatives SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry on Stress, Emotion, Neurodevelopment and Psychopathology CY MAY 14-16, 2015 CL Toronto, CANADA SP Soc Biol Psychiat DE Niacin; Schizophrenia; Endophenotypes; Biomarkers; Prostaglandins C1 [Messamore, Erik] Univ Cincinnati, Lindner Ctr HOPE, Dept Psychiat, Mason, OH USA. [Messamore, Erik; Dennis, Laura E.] Portland VA Med Ctr, Mental Hlth Div, Portland, OR USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0006-3223 EI 1873-2402 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD MAY 1 PY 2015 VL 77 IS 9 SU S MA 1036 BP 376S EP 376S PG 1 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA CF0BM UT WOS:000352207502229 ER PT J AU Yao, JK Curran, GL Poduslo, JF AF Yao, Jeffrey K. Curran, Geoffry L. Poduslo, Joseph F. TI Significant Correlations between Peripheral and Central Biomarkers in a Transgenic Mouse Model of Alzheimer'S Disease SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry on Stress, Emotion, Neurodevelopment and Psychopathology CY MAY 14-16, 2015 CL Toronto, CANADA SP Soc Biol Psychiat DE Alzheimer's Disease; Double transgenic mice; Biomarkers; Plasma; Brain cortex C1 [Yao, Jeffrey K.] VA Pittsburgh Healthcare Syst, Med Res Serv, Pittsburgh, PA USA. [Yao, Jeffrey K.] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA. [Yao, Jeffrey K.] Univ Pittsburgh, Sch Pharm, Dept Pharmaceut Sci, Pittsburgh, PA 15261 USA. [Curran, Geoffry L.] Mayo Clin, Dept Neurol, Coll Med, Rochester, MN USA. [Poduslo, Joseph F.] Mayo Clin, Coll Med, Dept Neurol Neurosci & Biochem Mol Biol, Rochester, MN USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0006-3223 EI 1873-2402 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD MAY 1 PY 2015 VL 77 IS 9 SU S MA 1093 BP 399S EP 399S PG 1 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA CF0BM UT WOS:000352207502286 ER PT J AU Badran, BW Taylor, JJ Devries, W McTeague, LM Li, XB Hanlon, C George, MS AF Badran, Bashar W. Taylor, Joseph J. Devries, William McTeague, Lisa M. Li, Xingbao Hanlon, Colleen George, Mark S. TI Using Interleaved Transcranial Magnetic Stimulation (TMS)/fMRI to Assess the BOLD Response Before and After a Single 20 minute Session of 10Hz rTMS SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry on Stress, Emotion, Neurodevelopment and Psychopathology CY MAY 14-16, 2015 CL Toronto, CANADA SP Soc Biol Psychiat DE TMS; fMRI; Depression; Brain Stimulation C1 [Badran, Bashar W.; Taylor, Joseph J.; Devries, William; McTeague, Lisa M.; Li, Xingbao; Hanlon, Colleen; George, Mark S.] Med Univ S Carolina, Psychiat & Behav Sci, Charleston, SC 29425 USA. [Badran, Bashar W.] Med Univ S Carolina, Neurosci Inst, Charleston, SC 29425 USA. [George, Mark S.] Ralph H Johnson VA Med Ctr, Neurol, Psychiat, Charleston, SC USA. NR 0 TC 0 Z9 0 U1 3 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0006-3223 EI 1873-2402 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD MAY 1 PY 2015 VL 77 IS 9 SU S MA 650 PG 1 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA CF0BM UT WOS:000352207501244 ER PT J AU Davis, MC Wynn, JK Weiner, K Hellemann, GS Green, MF Marder, SR AF Davis, Michael C. Wynn, Jonathan K. Weiner, Katherine Hellemann, Gerhard S. Green, Michael F. Marder, Stephen R. TI Randomized Controlled Trial of N-Acetylcysteine for Cognition and EEG Correlates in Schizophrenia SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry on Stress, Emotion, Neurodevelopment and Psychopathology CY MAY 14-16, 2015 CL Toronto, CANADA SP Soc Biol Psychiat DE n-acetylcysteine; NAC; schizophrenia; cognition; EEG C1 [Davis, Michael C.] Baylor Coll Med, Psychiat & Behav Sci, Houston, TX 77030 USA. [Davis, Michael C.] Michael E DeBakey VA Med Ctr, Mental Hlth Care Line, Houston, TX USA. [Wynn, Jonathan K.; Weiner, Katherine; Hellemann, Gerhard S.; Green, Michael F.; Marder, Stephen R.] UCLA Semel Inst, Psychiat & Biobehav Sci, Los Angeles, CA USA. [Wynn, Jonathan K.; Weiner, Katherine; Hellemann, Gerhard S.; Green, Michael F.; Marder, Stephen R.] VA Greater Los Angeles, Mental Illness Res Educ & Clin Ctr, Los Angeles, CA USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0006-3223 EI 1873-2402 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD MAY 1 PY 2015 VL 77 IS 9 SU S MA 523 PG 1 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA CF0BM UT WOS:000352207501117 ER PT J AU Ferri, J Eisendrath, SJ Fryer, SL Gillung, E Roach, BJ Mathalon, DH AF Ferri, Jamie Eisendrath, Stuart J. Fryer, Susanna L. Gillung, Erin Roach, Brian J. Mathalon, Daniel H. TI Blunted Amygdala Response During Affect Labeling in Treatment Resistant Depression Is Associated with Depression Severity SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry on Stress, Emotion, Neurodevelopment and Psychopathology CY MAY 14-16, 2015 CL Toronto, CANADA SP Soc Biol Psychiat DE Depression; Emotion; fMRI; amygdala; faces C1 [Ferri, Jamie; Eisendrath, Stuart J.; Fryer, Susanna L.; Gillung, Erin; Mathalon, Daniel H.] UCSF, Psychiat, San Francisco, CA USA. [Fryer, Susanna L.; Roach, Brian J.; Mathalon, Daniel H.] San Francisco VA Med Ctr, Mental Hlth Serv, San Francisco, CA USA. NR 0 TC 0 Z9 0 U1 3 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0006-3223 EI 1873-2402 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD MAY 1 PY 2015 VL 77 IS 9 SU S MA 449 PG 1 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA CF0BM UT WOS:000352207501051 ER PT J AU Fryer, SL Eisendrath, SJ Ferri, J Segal, ZV Roach, BJ Gillung, E Mathalon, DH AF Fryer, Susanna L. Eisendrath, Stuart J. Ferri, Jamie Segal, Zindel V. Roach, Brian J. Gillung, Erin Mathalon, Daniel H. TI Mindfulness-Based Cognitive Therapy Modulates Resting State Functional Brain Connectivity in Treatment-Resistant Depression: A Randomized Controlled Study SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry on Stress, Emotion, Neurodevelopment and Psychopathology CY MAY 14-16, 2015 CL Toronto, CANADA SP Soc Biol Psychiat DE mindfulness meditation; depression treatment outcome; functional connectivity; fMRI resting state; amygdala C1 [Fryer, Susanna L.; Eisendrath, Stuart J.; Ferri, Jamie; Gillung, Erin; Mathalon, Daniel H.] Univ Calif San Francisco, Psychiat, San Francisco, CA 94143 USA. [Fryer, Susanna L.; Ferri, Jamie; Roach, Brian J.; Mathalon, Daniel H.] San Francisco VA Med Ctr, Mental Hlth, San Francisco, CA USA. [Segal, Zindel V.] Univ Toronto, Psychiat, Toronto, ON, Canada. NR 0 TC 0 Z9 0 U1 6 U2 21 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0006-3223 EI 1873-2402 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD MAY 1 PY 2015 VL 77 IS 9 SU S MA 448 PG 1 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA CF0BM UT WOS:000352207501050 ER PT J AU Lin, JE Cohen, BE Neylan, TC Woolley, JD O'Donovan, A AF Lin, Joy E. Cohen, Beth E. Neylan, Thomas C. Woolley, Joshua D. O'Donovan, Aoife TI Social Isolation Is Associated with Elevated Inflammation in Patients without, but not with PTSD SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry on Stress, Emotion, Neurodevelopment and Psychopathology CY MAY 14-16, 2015 CL Toronto, CANADA SP Soc Biol Psychiat DE Social isolation; PTSD; Inflammation; Smoking; Perceived social support C1 [Lin, Joy E.] Univ Calif San Francisco, Sch Med, San Francisco, CA USA. [Lin, Joy E.; Neylan, Thomas C.; Woolley, Joshua D.; O'Donovan, Aoife] San Francisco VA Med Ctr, Psychiat, San Francisco, CA USA. [Cohen, Beth E.] Univ Calif San Francisco, Med, San Francisco, CA 94143 USA. [Cohen, Beth E.] San Francisco VA Med Ctr, Med, San Francisco, CA USA. [Neylan, Thomas C.; Woolley, Joshua D.; O'Donovan, Aoife] Univ Calif San Francisco, Psychiat, San Francisco, CA 94143 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0006-3223 EI 1873-2402 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD MAY 1 PY 2015 VL 77 IS 9 SU S MA 588 PG 2 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA CF0BM UT WOS:000352207501182 ER PT J AU Marton, TF Luongo, F Roach, B Sohal, V AF Marton, Tobias F. Luongo, Francisco Roach, Brian Sohal, Vikaas TI Optogenetic Dissection of mPFC Function During an Attention-Shifting Task in Mice SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry on Stress, Emotion, Neurodevelopment and Psychopathology CY MAY 14-16, 2015 CL Toronto, CANADA SP Soc Biol Psychiat DE attention; ERP; optogenetics; mice C1 [Marton, Tobias F.; Sohal, Vikaas] UCSF, Psychiat, San Francisco, CA USA. [Luongo, Francisco] UCSF, Grad Program Neurosci, San Francisco, CA USA. [Roach, Brian] San Francisco VA Med Ctr, Psychiat, San Francisco, CA USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0006-3223 EI 1873-2402 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD MAY 1 PY 2015 VL 77 IS 9 SU S MA 758 PG 1 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA CF0BM UT WOS:000352207501351 ER PT J AU Mithoefer, OJ Higgins, E George, MS Mithoefer, MC Hanlon, CA AF Mithoefer, Oliver J. Higgins, Edmund George, Mark S. Mithoefer, Michael C. Hanlon, Colleen A. TI The Effects of MDMA on Brain Reactivity to Personalized Trauma Scripts in Patients with PTSD: A Pilot Study SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry on Stress, Emotion, Neurodevelopment and Psychopathology CY MAY 14-16, 2015 CL Toronto, CANADA SP Soc Biol Psychiat DE post traumatic stress disorder; fMRI; exposure therapy; MDMA C1 [Mithoefer, Oliver J.; Higgins, Edmund; George, Mark S.; Hanlon, Colleen A.] Med Univ S Carolina, Dept Psychiat, Charleston, SC 29425 USA. [Higgins, Edmund] Med Univ S Carolina, Dept Family Med, Charleston, SC 29425 USA. [George, Mark S.; Hanlon, Colleen A.] Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA. [George, Mark S.] Ralph H Johnson VA Med Ctr, Psychiat, Charleston, SC USA. [Mithoefer, Michael C.] Multidisciplinary Assoc Psychedel Studies, Psychiat, San Diego, CA USA. [Mithoefer, Michael C.] Med Univ S Carolina, Dept Psychiat, Charelston, SC USA. NR 0 TC 0 Z9 0 U1 4 U2 27 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0006-3223 EI 1873-2402 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD MAY 1 PY 2015 VL 77 IS 9 SU S MA 630 PG 1 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA CF0BM UT WOS:000352207501224 ER PT J AU Peskind, ER Petrie, EC Mayer, C Pagulayan, K Huber, BR Meabon, J Raskind, MA Cook, DG Zhang, J Banks, W AF Peskind, Elaine R. Petrie, Eric C. Mayer, Cynthia Pagulayan, Kathleen Huber, Bertrand R. Meabon, James Raskind, Murray A. Cook, David G. Zhang, Jin Banks, William TI Cerebrospinal Fluid Biomarkers in Iraq and Afghanistan Veterans: Effects of Deployment and Blast Concussion Mild Traumatic Brain Injury SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry on Stress, Emotion, Neurodevelopment and Psychopathology CY MAY 14-16, 2015 CL Toronto, CANADA SP Soc Biol Psychiat DE biomarkers; CSF; mTBI; veterans C1 [Peskind, Elaine R.; Petrie, Eric C.; Mayer, Cynthia; Pagulayan, Kathleen; Huber, Bertrand R.; Meabon, James; Raskind, Murray A.] VA Puget Sound Hlth Care Syst, MIRECC, Seattle, WA USA. [Cook, David G.; Banks, William] VA Puget Sound Hlth Care Syst, GRECC, Seattle, WA USA. [Zhang, Jin] Univ Washington, Pathol, Seattle, WA 98195 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0006-3223 EI 1873-2402 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD MAY 1 PY 2015 VL 77 IS 9 SU S MA 555 PG 1 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA CF0BM UT WOS:000352207501149 ER PT J AU Singh, H Sittig, DF AF Singh, Hardeep Sittig, Dean F. TI Setting the record straight on measuring diagnostic errors. Reply to: 'Bad assumptions on primary care diagnostic errors' by Dr Richard Young SO BMJ QUALITY & SAFETY LA English DT Letter ID FOLLOW-UP; MEDICINE C1 [Singh, Hardeep] Baylor Coll Med, Michael E DeBakey Vet Affairs Med Ctr, Houston Vet Affairs Ctr Innovat Qual Effectivenes, Houston, TX 77030 USA. [Singh, Hardeep] Baylor Coll Med, Dept Med, Sect Hlth Serv Res, Houston, TX 77030 USA. [Sittig, Dean F.] Univ Texas Sch Biomed Informat, Houston, TX USA. [Sittig, Dean F.] UT Mem Hermann Ctr Healthcare Qual & Safety, Houston, TX USA. RP Singh, H (reprint author), VA Med Ctr 152, 2002 Holcombe Blvd, Houston, TX 77030 USA. EM hardeeps@bcm.edu FU VA Health Services Research and Development Service [CRE 12-033, 14-274]; VA National Center for Patient Safety; Agency for Health Care Research and Quality [R01HS022087]; Houston VA HSR&D Center for Innovations in Quality, Effectiveness and Safety [CIN 13-413] FX HS was supported by the VA Health Services Research and Development Service (CRE 12-033; Presidential Early Career Award for Scientists and Engineers USA 14-274), the VA National Center for Patient Safety and the Agency for Health Care Research and Quality (R01HS022087). This work was supported in part by the Houston VA HSR&D Center for Innovations in Quality, Effectiveness and Safety (CIN 13-413). NR 24 TC 1 Z9 1 U1 0 U2 1 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 2044-5415 EI 2044-5423 J9 BMJ QUAL SAF JI BMJ Qual. Saf. PD MAY PY 2015 VL 24 IS 5 BP 345 EP 348 DI 10.1136/bmjqs-2015-004140 PG 4 WC Health Care Sciences & Services; Health Policy & Services SC Health Care Sciences & Services GA CG1MX UT WOS:000353038100009 PM 25784768 ER PT J AU Hodnett, BL Schmitt, NC Clayburgh, DR Burkowsky, A Balzer, J Thirumala, PD Duvvuri, U AF Hodnett, Benjamin L. Schmitt, Nicole C. Clayburgh, Daniel R. Burkowsky, Alex Balzer, Jeffrey Thirumala, Parthasarathy D. Duvvuri, Umamaheswar TI Superior Laryngeal Nerve Monitoring Using Laryngeal Surface Electrodes and Intraoperative Neurophysiological Monitoring During Thyroidectomy SO CLINICAL ANATOMY LA English DT Article DE external branch of superior laryngeal nerve; nerve monitoring and stimulation; thyroid surgery ID EXTERNAL-BRANCH; SURGERY; ELECTROMYOGRAPHY; CONDUCTION AB The objective of this study is to establish normative waveform data for the external branch of the superior laryngeal nerve (SLN) utilizing laryngeal surface electrodes and intraoperative neurophysiological monitoring (IONM) in conjunction with a clinical neurophysiologist. A retrospective chart review of 91 consecutive at-risk SLN were identified in 51 patients in whom IONM using laryngeal surface electrodes was performed by a clinical neurophysiologist using Dragonfly (Neurovision Medical Products, Ventura, CA) recording electrodes and a Protektor (Natus Medical Inc., San Carlos, CA)16 channel- intraoperative nerve monitoring system. Inclusion criteria were met for 30 SLN. Data collected included preoperative diagnosis, surgical procedure, rates of nerve identification and stimulation, and waveform characteristics. Waveform analysis for 30 SLN yielded a peak latency of 4.0 +/- 0.2 ms, onset latency 2.3 +/- 0.1 ms, peak-to-peak amplitude of 220.4 +/- 31.1 mu V, onset-to-peak amplitude of 186.0 +/- 25.0 mu V, and stimulation current threshold of 0.55 +/- 0.03 mA (data=mean +/- SEM). Two patients had abnormal SLN function documented clinically on postoperative laryngoscopic examination. Laryngeal surface electrodes were successfully utilized to identify and monitor SLN function intraoperatively. IONM using laryngeal surface electrodes enables analysis of waveform morphology and latency in addition to threshold and amplitude data obtained with the traditional NIM system, potentially improving the performance of nerve monitoring during thyroid surgery. Clin. Anat. 28:460-466, 2015. (c) 2014 Wiley Periodicals, Inc. C1 [Hodnett, Benjamin L.; Schmitt, Nicole C.] Univ Pittsburgh, Med Ctr, Dept Otolaryngol, Inst Eye & Ear, Pittsburgh, PA 15213 USA. [Clayburgh, Daniel R.] Oregon Hlth & Sci Univ, Dept Otolaryngol Head & Neck Surg, Portland, OR 97201 USA. [Burkowsky, Alex] UPMC Presbyterian Hosp, Procirca Ctr Clin Neurophysiol CCN, Clin Neurophysiol Tech, Pittsburgh, PA USA. [Balzer, Jeffrey] UPMC Presbyterian Hosp, Ctr Clin Neurophysiol CCN, Neurosci & Acute & Tertiary Care Nursing, Pittsburgh, PA USA. [Thirumala, Parthasarathy D.] UPMC Presbyterian Hosp, Ctr Clin Neurophysiol CCN, Pittsburgh, PA USA. [Duvvuri, Umamaheswar] Univ Pittsburgh, Med Ctr, VA Pittsburgh Hlth Syst, Inst Eye & Ear, Pittsburgh, PA 15213 USA. RP Duvvuri, U (reprint author), Univ Pittsburgh, Med Ctr, VA Pittsburgh Hlth Syst, Inst Eye & Ear, 200 Lothrop St,Suite 500, Pittsburgh, PA 15213 USA. EM duvvuriu@upmc.edu FU Department of Veterans Affairs, BLSRD; PNC Foundation (UD) FX Contract Grant sponsor: Department of Veterans Affairs, BLSR&D, and the PNC Foundation (UD). NR 16 TC 2 Z9 2 U1 2 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0897-3806 EI 1098-2353 J9 CLIN ANAT JI Clin. Anat. PD MAY PY 2015 VL 28 IS 4 BP 460 EP 466 DI 10.1002/ca.22487 PG 7 WC Anatomy & Morphology SC Anatomy & Morphology GA CG1OB UT WOS:000353041400010 PM 25425500 ER PT J AU Johansen, KL Lee, C AF Johansen, Kirsten L. Lee, Carol TI Body composition in chronic kidney disease SO CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION LA English DT Review DE frailty; obesity; physical function; sarcopenia; visceral fat ID RANDOMIZED CONTROLLED-TRIAL; QUALITY-OF-LIFE; MAINTENANCE HEMODIALYSIS-PATIENTS; PERITONEAL-DIALYSIS PATIENTS; SKELETAL-MUSCLE MASS; STAGE RENAL-DISEASE; NANDROLONE DECANOATE; RESISTANCE EXERCISE; ADIPONECTIN LEVELS; ADIPOSE-TISSUE AB Purpose of review To summarize the latest information on body composition among patients with chronic kidney disease and its association with outcomes. Recent findings Obesity is increasing among patients with end-stage renal disease and is more prevalent when direct measures of adiposity are used rather than BMI. High BMI is not associated with better survival among patients with earlier chronic kidney disease or after kidney transplantation, suggesting that excess fat is most protective among the sickest patients. Despite the positive association between BMI and survival among patients with end-stage renal disease, visceral fat is associated with coronary artery calcification and adverse cardiovascular events. Muscle wasting is prominent among patients with chronic kidney disease, sometimes even in the setting of obesity. Obesity and muscle wasting are associated with worse physical functioning. Indicators of low muscle size and strength are associated with higher mortality. Some interventions can affect body composition, but whether they affect survival has not been determined. Summary Recent studies show that a high BMI is not protective for all patients with chronic kidney disease and is associated with poor physical functioning and frailty. Visceral adiposity is associated with adverse cardiovascular outcomes. Sarcopenia is common among patients with end-stage renal disease and is associated with worse physical performance and higher mortality. C1 [Johansen, Kirsten L.; Lee, Carol] Univ Calif San Francisco, Div Nephrol, San Francisco, CA 94143 USA. RP Johansen, KL (reprint author), San Francisco VA Med Ctr, Nephrol Sect, Box 111J,4150 Clement St, San Francisco, CA 94121 USA. EM Kirsten.johansen@ucsf.edu FU National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases [DK085153]; Department of Veterans Affairs FX K.L.J. is supported by National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases grant DK085153. C.L. was supported by a nephrology research fellowship from the Department of Veterans Affairs. NR 61 TC 5 Z9 6 U1 1 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1062-4821 EI 1473-6543 J9 CURR OPIN NEPHROL HY JI Curr. Opin. Nephrol. Hypertens. PD MAY PY 2015 VL 24 IS 3 BP 268 EP 275 DI 10.1097/MNH.0000000000000120 PG 8 WC Urology & Nephrology; Peripheral Vascular Disease SC Urology & Nephrology; Cardiovascular System & Cardiology GA CF8FO UT WOS:000352791700010 PM 25887900 ER PT J AU Ragen, BJ Seidel, J Chollak, C Pietrzak, RH Neumeister, A AF Ragen, Benjamin J. Seidel, Jordan Chollak, Christine Pietrzak, Robert H. Neumeister, Alexander TI Investigational drugs under development for the treatment of PTSD SO EXPERT OPINION ON INVESTIGATIONAL DRUGS LA English DT Review DE evidence-based; neurobiology; posttraumatic stress disorder; treatment ID POSTTRAUMATIC-STRESS-DISORDER; ACID AMIDE HYDROLASE; METABOTROPIC GLUTAMATE RECEPTORS; KAPPA-OPIOID-RECEPTOR; FEAR-POTENTIATED STARTLE; ANTIDEPRESSANT-LIKE ACTIVITY; NATIONAL COMORBIDITY SURVEY; RANDOMIZED CLINICAL-TRIAL; PLACEBO-CONTROLLED TRIAL; COMBAT-RELATED PTSD AB Introduction: Posttraumatic stress disorder (PTSD) is a prevalent, chronic and disabling anxiety disorder that may develop following exposure to a traumatic event. There is currently no effective pharmacotherapy for PTSD and therefore the discovery of novel, evidence-based treatments is particularly important. This review of potential novel treatments could act as a catalyst for further drug investigation. Areas covered: In this review, the authors discuss the heterogeneity of PTSD and why this provides a challenge for discovering effective treatments for this disorder. By searching for the neurobiological systems that are disrupted in individuals with PTSD and their correlation with different symptoms, the authors propose potential pharmacological treatments that could target these symptoms. They discuss drugs such as nabilone, D-cycloserine, nor-BNI, 7,8-dihydroxyflavone and oxytocin (OT) to target systems such as cannabinoids, glutamate, opioids, brain-derived neurotrophic factor and the OT receptor, respectively. While not conclusive, the authors believe that these brain systems include promising targets for drug discovery. Finally, the authors review animal studies, proof-of-concept studies and case studies that support our proposed treatments. Expert opinion: A mechanism-based approach utilizing techniques such as in vivo neuroimaging will allow for the determination of treatments. Due to the heterogeneity of the PTSD phenotype, focusing on symptomology rather than a categorical diagnosis will allow for more personalized treatment. Furthermore, there appears to be a promise in drugs as cognitive enhancers, the use of drug cocktails and novel compounds that target specific pathways linked to the etiology of PTSD. C1 [Ragen, Benjamin J.; Seidel, Jordan; Chollak, Christine] NYU, Sch Med, Dept Psychiat, New York, NY 10016 USA. [Pietrzak, Robert H.] US Dept Vet Affairs, VA Connecticut Healthcare Syst, Clin Neurosci Div, Natl Ctr Posttraumat Stress Disorder, West Haven, CT USA. [Pietrzak, Robert H.] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA. [Neumeister, Alexander] NYU, Sch Med, Dept Radiol, Mol Imaging Program Anxiety & Mood Disorders, New York, NY 10016 USA. RP Neumeister, A (reprint author), NYU, Sch Med, Dept Radiol, Mol Imaging Program Anxiety & Mood Disorders, One Pk Ave,8th Floor,Room 225, New York, NY 10016 USA. EM alexander.neumeister@nyumc.org FU National Institutes of Health [R21MH096105, R21MH085627, R34MH102871, RO1MH096876, RO1MH102566]; Office of the Assistant Secretary of Defense for Health Affairs [W81XWH-14-1-0084]; Pfizer, Inc. FX This project was supported by the National Institutes of Health through the following awards: R21MH096105, R21MH085627, R34MH102871, RO1MH096876 and RO1MH102566; the Office of the Assistant Secretary of Defense for Health Affairs under Award No. W81XWH-14-1-0084. The Clinical Neurosciences Division of the United States Department of Veterans Affairs National Center for Posttraumatic Stress Disorder. Opinions, interpretations, conclusions and recommendations are those of the author and are not necessarily endorsed by the Department of Defense, the NIH or VA. A Neumeister has received consulting fees from Pfizer, Inc. This activity is unrelated to the present publication. A Neumeister has received material support from Eli Lilly & Co. Eli Lilly & Co. has supported the development of [11C]LY2795050, which is unrelated to the present publication. R Pietrzak is a scientific consultant to Cogstate, Ltd. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. NR 163 TC 4 Z9 4 U1 6 U2 18 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1354-3784 EI 1744-7658 J9 EXPERT OPIN INV DRUG JI Expert Opin. Investig. Drugs PD MAY PY 2015 VL 24 IS 5 BP 659 EP 672 DI 10.1517/13543784.2015.1020109 PG 14 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA CF6EF UT WOS:000352648800006 PM 25773140 ER PT J AU Nelson, RE Jones, M Liu, CF Samore, MH Evans, ME Graves, N Lee, B Rubin, MA AF Nelson, Richard E. Jones, Makoto Liu, Chuan-Fen Samore, Matthew H. Evans, Martin E. Graves, Nicholas Lee, Bruce Rubin, Michael A. TI The Impact of Healthcare-Associated Methicillin-Resistant Staphylococcus Aureus Infections on Post-Discharge Healthcare Costs and Utilization SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article ID SURGICAL SITE INFECTIONS; UNITED-STATES; HOSPITAL DISCHARGE; OUTCOMES; BURDEN; PNEUMONIA; MEDICARE; PROGRAM; DISEASE; BALANCE AB OBJECTIVE. Healthcare-associated methicillin-resistant Staphylococcus aureus (MRSA) infections are a major cause of morbidity, mortality, and cost among hospitalized patients. Little is known about their impact on post-discharge resource utilization. The purpose of this study was to estimate post-discharge healthcare costs and utilization attributable to positive MRSA cultures during a hospitalization. METHODS. Our study cohort consisted of patients with an inpatient admission lasting longer than 48 hours within the US Department of Veterans Affairs (VA) system between October 1, 2007, and November 30, 2010. Of these patients, we identified those with a positive MRSA culture from microbiology reports in the VA electronic medical record. We used propensity score matching and multivariable regression models to assess the impact of positive culture on post-discharge outpatient, inpatient, and pharmacy costs and utilization in the 365 days following discharge. RESULTS. Our full cohort included 369,743 inpatients, of whom, 3,599 (1.0%) had positive MRSA cultures. Our final analysis sample included 3,592 matched patients with and without positive cultures. We found that, in the 12 months following hospital discharge, having a positive culture resulted in increases in post-discharge pharmacy costs ($776, P<.0001) and inpatient costs ($12,167, P<.0001). Likewise, having a positive culture increased the risk of a readmission (odds ratio [OR] = 1.396, P<.0001), the number of prescriptions (incidence rate ratio [IRR], 1.138; P<.0001) and the number of inpatient days (IRR, 1.204; P<. 0001,) but decreased the number of subsequent outpatient encounters (IRR, 0.941; P<.008). CONCLUSIONS. The results of this study indicate that MRSA infections are associated with higher levels of post-discharge healthcare cost and utilization. These findings indicate that financial benefits resulting from infection prevention efforts may extend beyond the initial hospital stay. C1 [Nelson, Richard E.; Jones, Makoto; Samore, Matthew H.; Rubin, Michael A.] Vet Affairs Salt Lake City Hlth Care Syst, Salt Lake City, UT USA. [Nelson, Richard E.; Jones, Makoto; Samore, Matthew H.; Rubin, Michael A.] Univ Utah, Sch Med, Dept Internal Med, Salt Lake City, UT USA. [Liu, Chuan-Fen] Vet Affairs Puget Sound Hlth Care Syst, Seattle, WA USA. [Liu, Chuan-Fen] Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA. [Evans, Martin E.] Lexington Vet Affairs Med Ctr, Lexington, KY USA. [Evans, Martin E.] Vet Hlth Adm, Natl Infect Dis Serv, MRSA, MDRO Program, Lexington, KY USA. [Evans, Martin E.] Univ Kentucky, Dept Internal Med, Lexington, KY USA. [Graves, Nicholas] Queensland Univ Technol, Sch Publ Hlth, Brisbane, Qld 4001, Australia. [Graves, Nicholas] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld 4001, Australia. [Lee, Bruce] Johns Hopkins Univ, Dept Int Hlth, Baltimore, MD USA. RP Nelson, RE (reprint author), 500 Foothill Blvd, Salt Lake City, UT 84148 USA. EM richard.nelson@utah.edu FU Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Health Services Research and Development Service [CDA 11-210] FX The research reported here was supported by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Health Services Research and Development Service (CDA 11-210). NR 39 TC 6 Z9 6 U1 2 U2 9 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0899-823X EI 1559-6834 J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD MAY PY 2015 VL 36 IS 5 BP 534 EP 542 DI 10.1017/ice.2015.22 PG 9 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA CG1MP UT WOS:000353037100005 PM 25715806 ER PT J AU Steinhilber, S Estrada, CA AF Steinhilber, Starr Estrada, Carlos A. TI To Lead or Not to Lead? Structure and Content of Leadership Development Programs SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Editorial Material ID MULTISOURCE FEEDBACK; SCHOLARS PROGRAM; FACULTY; MANAGERS; SKILLS C1 [Steinhilber, Starr] Univ Alabama Birmingham, Tinsley Harrison Internal Med Residency Training, Birmingham, AL 35294 USA. [Estrada, Carlos A.] Univ Alabama Birmingham, Div Gen Internal Med, Birmingham, AL 35294 USA. [Estrada, Carlos A.] Birmingham Vet Affairs Med Ctr, Birmingham, AL USA. RP Estrada, CA (reprint author), Univ Alabama Birmingham, Div Gen Internal Med, 720 Fac Off Tower,510 20th St South, Birmingham, AL 35294 USA. EM cestrada@uab.edu NR 16 TC 0 Z9 0 U1 2 U2 8 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD MAY PY 2015 VL 30 IS 5 BP 543 EP 545 DI 10.1007/s11606-015-3240-7 PG 3 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CF7CJ UT WOS:000352713400005 PM 25701050 ER PT J AU Johnson, HM Olson, AG LaMantia, JN Kind, AJH Pandhi, N Mendonca, EA Craven, M Smith, MA AF Johnson, Heather M. Olson, Andrea G. LaMantia, Jamie N. Kind, Amy J. H. Pandhi, Nancy Mendonca, Eneida A. Craven, Mark Smith, Maureen A. TI Documented Lifestyle Education Among Young Adults with Incident Hypertension SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Article DE hypertension; patient education; primary care; electronic health records; health behavior ID AMERICAN-HEART-ASSOCIATION; HEALTH-CARE PROFESSIONALS; BLOOD-PRESSURE; ADMINISTRATIVE DATA; COMPETING DEMANDS; PREVENTIVE CARE; FAMILY-HISTORY; RISK-FACTORS; PHYSICIAN; PREVALENCE AB Only 38 % of young adults with hypertension have controlled blood pressure. Lifestyle education is a critical initial step for hypertension control. Previous studies have not assessed the type and frequency of lifestyle education in young adults with incident hypertension. The purpose of this study was to determine patient, provider, and visit predictors of documented lifestyle education among young adults with incident hypertension. We conducted a retrospective analysis of manually abstracted electronic health record data. A random selection of adults 18-39 years old (n = 500), managed by a large academic practice from 2008 to 2011 and who met JNC 7 clinical criteria for incident hypertension, participated in the study. The primary outcome was the presence of any documented lifestyle education during one year after meeting criteria for incident hypertension. Abstracted topics included documented patient education for exercise, tobacco cessation, alcohol use, stress management/stress reduction, Dietary Approaches to Stop Hypertension (DASH) diet, and weight loss. Clinic visits were categorized based upon a modified established taxonomy to characterize patients' patterns of outpatient service. We excluded patients with previous hypertension diagnoses, previous antihypertensive medications, or pregnancy. Logistic regression was used to identify predictors of documented education. Overall, 55 % (n = 275) of patients had documented lifestyle education within one year of incident hypertension. Exercise was the most frequent topic (64 %). Young adult males had significantly decreased odds of receiving documented education. Patients with a previous diagnosis of hyperlipidemia or a family history of hypertension or coronary artery disease had increased odds of documented education. Among visit types, chronic disease visits predicted documented lifestyle education, but not acute or other/preventive visits. Among young adults with incident hypertension, only 55 % had documented lifestyle education within one year. Knowledge of patient, provider, and visit predictors of education can help better target the development of interventions to improve young adult health education and hypertension control. C1 [Johnson, Heather M.; Olson, Andrea G.; LaMantia, Jamie N.; Kind, Amy J. H.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med, Madison, WI 53792 USA. [Johnson, Heather M.; LaMantia, Jamie N.; Kind, Amy J. H.; Pandhi, Nancy; Smith, Maureen A.] Univ Wisconsin, Sch Med & Publ Hlth, Hlth Innovat Program, Madison, WI 53792 USA. [Kind, Amy J. H.] William S Middleton Mem Vet Adm Med Ctr, Geriatr Res Educ & Clin Ctr, Madison, WI USA. [Pandhi, Nancy; Smith, Maureen A.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Family Med, Madison, WI 53792 USA. [Mendonca, Eneida A.; Craven, Mark] Univ Wisconsin, Sch Med & Publ Hlth, Dept Biostat & Med Informat, Madison, WI 53792 USA. [Mendonca, Eneida A.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Pediat, Madison, WI 53792 USA. [Smith, Maureen A.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Populat Hlth Sci, Madison, WI 53792 USA. [Smith, Maureen A.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Surg, Madison, WI 53792 USA. [Johnson, Heather M.] Univ Wisconsin, Sch Med & Publ Hlth, Div Cardiovasc Med, Madison, WI 53792 USA. RP Johnson, HM (reprint author), Univ Wisconsin, Sch Med & Publ Hlth, Div Cardiovasc Med, H4-512 CSC,MC 3248 600 Highland Ave, Madison, WI 53792 USA. EM Hm2@medicine.wisc.edu RI Mendonca, Eneida/J-8895-2016 OI Mendonca, Eneida/0000-0003-4297-9221; Johnson, Heather/0000-0002-4916-3519 FU National Center for Research Resources (NCRR) [UL1RR025011]; National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health [U54TR000021]; National Heart, Lung, and Blood Institute of the National Institutes of Health [K23HL112907]; University of Wisconsin Centennial Scholars Program of the University of Wisconsin School of Medicine and Public Health; National Institute on Aging of the National Institutes of Health [K23AG034551, K08AG029527]; American Federation for Aging Research; Atlantic Philanthropies; Starr Foundation; Madison VA Geriatric Research, Education, and Clinical Center; University of Wisconsin Health Innovation Program; University of Wisconsin School of Medicine and Public Health from the Wisconsin Partnership Program FX Research reported in this manuscript was supported by the Health Innovation Program and the Clinical and Translational Science Award (CTSA) program, previously through the National Center for Research Resources (NCRR) under award number UL1RR025011, and now by the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health under award number U54TR000021. Heather Johnson is supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health under award number K23HL112907, and also by the University of Wisconsin Centennial Scholars Program of the University of Wisconsin School of Medicine and Public Health. Amy Kind is supported by the National Institute on Aging of the National Institutes of Health under award number K23AG034551, the American Federation for Aging Research, the Atlantic Philanthropies, the Starr Foundation, and the Madison VA Geriatric Research, Education, and Clinical Center. Nancy Pandhi is supported by the National Institute on Aging of the National Institutes of Health under award number K08AG029527. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Additional funding for this project was provided by the University of Wisconsin Health Innovation Program and the University of Wisconsin School of Medicine and Public Health from the Wisconsin Partnership Program. NR 60 TC 6 Z9 6 U1 2 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD MAY PY 2015 VL 30 IS 5 BP 556 EP 564 DI 10.1007/s11606-014-3059-7 PG 9 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CF7CJ UT WOS:000352713400009 PM 25373831 ER PT J AU Kiefer, MM Silverman, JB Young, BA Nelson, KM AF Kiefer, Meghan M. Silverman, Julie B. Young, Bessie A. Nelson, Karin M. TI National Patterns in Diabetes Screening: Data from the National Health and Nutrition Examination Survey (NHANES) 2005-2012 SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Article DE diabetes screening; prediabetes; NHANES; ADA; disparities ID MANAGED CARE POPULATION; ETHNIC-DIFFERENCES; GLUCOSE CONTROL; SELF-REPORT; FOLLOW-UP; MORTALITY; COHORT; COMPLICATIONS; INTERVENTION; PARTICIPANTS AB There are few current population-based estimates of the patterns of diabetes screening in the United States. The American Diabetes Association (ADA) recommends universal screening of adults a parts per thousand yen 45 years, and high-risk adults < 45 years, but there is no current assessment of ADA guideline performance in detecting diabetes and prediabetes. Furthermore, data on racial/ethnic patterns of screening are limited. Our aim was to estimate diabetes screening prevalence for the US adult population and specifically for those who meet ADA criteria; to report the prevalence of prediabetes and diabetes among these groups; and to determine if high-risk race/ethnicity was associated with reported screening. This was a Cross-sectional survey. Non-pregnant adults (a parts per thousand yen 21 years) without diabetes or prediabetes who participated in the National Health and Nutrition Examination Survey (NHANES) in 2005-2012 (n = 17,572) were included in the study. "Screening-recommended" participants, classified by ADA criteria, included (1) adults a parts per thousand yen 45 years and (2) "high-risk" adults < 45 years. "Screening-not-recommended" participants were adults < 45 years who did not meet criteria. Diabetes screening status was obtained by self-report. We used calibrated HbA(1c) and/or fasting glucose levels to define undiagnosed diabetes and prediabetes. Seventy-six percent of the study population (approximately 136 million US adults) met ADA criteria. Among them, less than half (46.2 %) reported screening; undiagnosed diabetes affected 3.7 % (5 million individuals), and undiagnosed prediabetes affected 36.3 % (49 million people.) African Americans were more likely to report screening, both among adults a parts per thousand yen 45 years and among "high risk" younger adults (OR 1.27 and 1.36, respectively.) Hispanic participants were also more likely to report screening (OR 1.31 for older adults, 1.42 for younger adults.) The screening rate among "screening-not-recommended" adults was 29.6 %; the prevalence of diabetes and prediabetes were 0.4 and 10.2 %, respectively. In a nationally representative sample, 76 % of adults met ADA screening criteria, of whom fewer than half reported screening. Limitations include cross-sectional design and screening self-report. C1 [Kiefer, Meghan M.; Nelson, Karin M.] Univ Washington Sch Med, Div Gen Internal Med, Dept Med, Seattle, WA USA. [Kiefer, Meghan M.] Harborview Med Ctr, Adult Med Clin, Seattle, WA 98195 USA. [Silverman, Julie B.; Young, Bessie A.; Nelson, Karin M.] VA Puget Sound Healthcare Syst, Northwest HSR&D Ctr Excellence, Seattle, WA USA. [Silverman, Julie B.; Young, Bessie A.; Nelson, Karin M.] Univ Washington Sch Publ Hlth, Dept Hlth Serv, Seattle, WA USA. RP Kiefer, MM (reprint author), Harborview Med Ctr, Adult Med Clin, 325 9th Ave,Box 356420, Seattle, WA 98195 USA. EM meghanm@uw.edu FU Ruth L. Kirschstein National Research Service through the University of Washington; VA Puget Sound Health Care System, Seattle WA FX The first author's salary is provided by the Ruth L. Kirschstein National Research Service through the University of Washington; the work was also supported by resources from the VA Puget Sound Health Care System, Seattle WA. The funding sources had no role in the design, conduct, or analysis of the study, or the decision to submit the manuscript for publication. NR 28 TC 3 Z9 3 U1 4 U2 10 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD MAY PY 2015 VL 30 IS 5 BP 612 EP 618 DI 10.1007/s11606-014-3147-8 PG 7 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CF7CJ UT WOS:000352713400016 PM 25533392 ER PT J AU Couts, KL Nakachi, I Luo, Y Van, H Fujisawa, A Robinson, S Robinson, W Geraci, M Fujita, M AF Couts, K. L. Nakachi, I. Luo, Y. Van, H. Fujisawa, A. Robinson, S. Robinson, W. Geraci, M. Fujita, M. TI Identification of a pre-programmed metastasis-associated homozygous deletion in Chr2q37.3 in human melanoma SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT Annual Meeting of the Society-for-Investigative-Dermatology CY MAY 06-09, 2015 CL Atlanta, GA SP Soc Investigat Dermatol C1 [Couts, K. L.; Luo, Y.; Van, H.; Fujisawa, A.; Fujita, M.] Univ Colorado, AMC, Dermatol, Aurora, CO USA. [Nakachi, I.; Robinson, S.; Geraci, M.] Univ Colorado, AMC, Med, Aurora, CO USA. [Robinson, W.] Univ Colorado, AMC, Med Oncol, Aurora, CO USA. [Fujita, M.] Denver VA Med Ctr, Denver, CO USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0022-202X EI 1523-1747 J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD MAY PY 2015 VL 135 SU 1 MA 106 BP S18 EP S18 PG 1 WC Dermatology SC Dermatology GA CF8CO UT WOS:000352783200107 ER PT J AU Grigoryan, K Best, A Dellavalle, R AF Grigoryan, K. Best, A. Dellavalle, R. TI University tort liability for allowing college debit card purchasing of indoor UV tanning SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT Annual Meeting of the Society-for-Investigative-Dermatology CY MAY 06-09, 2015 CL Atlanta, GA SP Soc Investigat Dermatol C1 [Grigoryan, K.] Univ Cincinnati, Coll Med, Cincinnati, OH USA. [Dellavalle, R.] Univ Colorado Denver, Denver VAMC, Denver, CO USA. [Best, A.] Univ Denver, Sturm Coll Law, Denver, CO USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0022-202X EI 1523-1747 J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD MAY PY 2015 VL 135 SU 1 MA 270 BP S46 EP S46 PG 1 WC Dermatology SC Dermatology GA CF8CO UT WOS:000352783200271 ER PT J AU Hagstrom, EL Patel, S Boyers, LN Karimkhani, C Dunnick, C Dellavalle, R AF Hagstrom, E. L. Patel, S. Boyers, L. N. Karimkhani, C. Dunnick, C. Dellavalle, R. TI Comparing cutaneous research funded by the National Institutes of Health with the United States skin disease burden SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT Annual Meeting of the Society-for-Investigative-Dermatology CY MAY 06-09, 2015 CL Atlanta, GA SP Soc Investigat Dermatol C1 [Karimkhani, C.] Columbia Univ Coll Phys & Surg, New York, NY 10032 USA. [Hagstrom, E. L.] Loyola Univ Chicago, Stritch Sch Med, Maywood, IL USA. [Patel, S.] Med Univ S Carolina, Charleston, SC 29425 USA. [Boyers, L. N.] Georgetown Univ, Sch Med, Washington, DC USA. [Dunnick, C.; Dellavalle, R.] Univ Colorado, Dept Dermatol, Aurora, CO USA. [Dunnick, C.] US Dept Vet Affairs, Dermatol Serv, Eastern Colorado Hlth Care Syst, Denver, CO USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0022-202X EI 1523-1747 J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD MAY PY 2015 VL 135 SU 1 MA 300 BP S51 EP S51 PG 1 WC Dermatology SC Dermatology GA CF8CO UT WOS:000352783200301 ER PT J AU Jayanthy, A Setaluri, V AF Jayanthy, A. Setaluri, V. TI Identification of MITF regulated microRNAs in melanoma SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT Annual Meeting of the Society-for-Investigative-Dermatology CY MAY 06-09, 2015 CL Atlanta, GA SP Soc Investigat Dermatol C1 [Jayanthy, A.; Setaluri, V.] Univ Wisconsin, Dermatol, Madison, WI USA. [Setaluri, V.] William S Middleton Mem Vet Adm Med Ctr, Madison, WI USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0022-202X EI 1523-1747 J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD MAY PY 2015 VL 135 SU 1 MA 470 BP S80 EP S80 PG 1 WC Dermatology SC Dermatology GA CF8CO UT WOS:000352783200470 ER PT J AU Karimkhani, C Boyers, LN Schilling, LM Dellavalle, R AF Karimkhani, C. Boyers, L. N. Schilling, L. M. Dellavalle, R. TI Bradford hill criteria support the surgeon general stating that indoor ultraviolet tanning causes skin cancer SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT Annual Meeting of the Society-for-Investigative-Dermatology CY MAY 06-09, 2015 CL Atlanta, GA SP Soc Investigat Dermatol C1 [Karimkhani, C.] Columbia Univ Coll Phys & Surg, New York, NY 10032 USA. [Boyers, L. N.] Georgetown Univ, Sch Med, Washington, DC USA. [Schilling, L. M.] Univ Colorado, Dept Med, Aurora, CO USA. [Dellavalle, R.] Univ Colorado, Dept Dermatol, Aurora, CO USA. [Dellavalle, R.] Colorado Sch Publ Hlth, Dept Epidemiol, Aurora, CO USA. [Dellavalle, R.] US Dept Vet Affairs, Dermatol Serv, Eastern Colorado Hlth Care Syst, Denver, CO USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0022-202X EI 1523-1747 J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD MAY PY 2015 VL 135 SU 1 MA 313 BP S54 EP S54 PG 1 WC Dermatology SC Dermatology GA CF8CO UT WOS:000352783200313 ER PT J AU Katiyar, SK Singh, T Prasad, R AF Katiyar, S. K. Singh, T. Prasad, R. TI Drinking green tea inhibits photocarcinogenesis in mice by upregulating the levels of miRNA-29 and subsequently inhibition of DNA hypermethylation in tumors SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT Annual Meeting of the Society-for-Investigative-Dermatology CY MAY 06-09, 2015 CL Atlanta, GA SP Soc Investigat Dermatol C1 [Katiyar, S. K.; Singh, T.; Prasad, R.] Univ Alabama Birmingham, Birmingham, AL USA. [Katiyar, S. K.] Birmingham VA Med Ctr, Birmingham, AL USA. NR 0 TC 0 Z9 0 U1 1 U2 5 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0022-202X EI 1523-1747 J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD MAY PY 2015 VL 135 SU 1 MA 579 BP S99 EP S99 PG 1 WC Dermatology SC Dermatology GA CF8CO UT WOS:000352783200579 ER PT J AU Luo, Y Arcaroli, JJ Nguyen, N Liu, S Kutty, L Bagby, S Robinson, S Robinson, W Norris, D Messersmith, W Fujita, M AF Luo, Y. Arcaroli, J. J. Nguyen, N. Liu, S. Kutty, L. Bagby, S. Robinson, S. Robinson, W. Norris, D. Messersmith, W. Fujita, M. TI CDK1 enhances tumor initiation and stemness by interacting with stem cell genes in human cancers SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT Annual Meeting of the Society-for-Investigative-Dermatology CY MAY 06-09, 2015 CL Atlanta, GA SP Soc Investigat Dermatol C1 [Luo, Y.; Nguyen, N.; Liu, S.; Kutty, L.; Norris, D.; Fujita, M.] Univ Colorado Denver, Dermatol, Aurora, CO USA. [Arcaroli, J. J.; Bagby, S.; Robinson, S.; Robinson, W.; Messersmith, W.] Univ Colorado Denver, Med, Aurora, CO USA. [Norris, D.; Fujita, M.] Denver VA Med Ctr, Denver, CO USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0022-202X EI 1523-1747 J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD MAY PY 2015 VL 135 SU 1 MA 624 BP S108 EP S108 PG 1 WC Dermatology SC Dermatology GA CF8CO UT WOS:000352783200624 ER PT J AU Prasad, R Singh, T Vaid, M Katiyar, SK AF Prasad, R. Singh, T. Vaid, M. Katiyar, S. K. TI A meta-analysis of microRNAs expression profile in UV-radiation induced skin tumors SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT Annual Meeting of the Society-for-Investigative-Dermatology CY MAY 06-09, 2015 CL Atlanta, GA SP Soc Investigat Dermatol C1 [Prasad, R.; Singh, T.; Vaid, M.; Katiyar, S. K.] Univ Alabama Birmingham, Dermatol, Birmingham, AL USA. [Katiyar, S. K.] Birmingham VA Med Ctr, Birmingham, AL USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0022-202X EI 1523-1747 J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD MAY PY 2015 VL 135 SU 1 MA 578 BP S99 EP S99 PG 1 WC Dermatology SC Dermatology GA CF8CO UT WOS:000352783200578 ER PT J AU Self, A Karimkhani, C Grigoryan, K Lott, JP Dellavalle, R AF Self, A. Karimkhani, C. Grigoryan, K. Lott, J. P. Dellavalle, R. TI Advertisement of indoor tanning to minors through high school newspapers SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT Annual Meeting of the Society-for-Investigative-Dermatology CY MAY 06-09, 2015 CL Atlanta, GA SP Soc Investigat Dermatol C1 [Self, A.] Univ Colorado, Sch Med, Aurora, CO USA. Columbia Univ, Coll Phys & Surg, New York, NY USA. Univ Cincinnati, Coll Med, Cincinnati, OH USA. [Lott, J. P.] Yale Univ, Robert Wood Johnson Fdn Clin Scholars Program, New Haven, CT USA. [Dellavalle, R.] US Dept Vet Affairs, Dermatol Serv, Eastern Colorado Hlth Care Syst, Denver, CO USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0022-202X EI 1523-1747 J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD MAY PY 2015 VL 135 SU 1 MA 333 BP S57 EP S57 PG 1 WC Dermatology SC Dermatology GA CF8CO UT WOS:000352783200333 ER PT J AU Zhai, Z Liu, W Kaur, M Luo, Y Norris, D Spritz, RA Dinarello, CA Fujita, M AF Zhai, Z. Liu, W. Kaur, M. Luo, Y. Norris, D. Spritz, R. A. Dinarello, C. A. Fujita, M. TI Notch1 confers melanoma resistance to temozolomide through NLRP1 upregulation SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT Annual Meeting of the Society-for-Investigative-Dermatology CY MAY 06-09, 2015 CL Atlanta, GA SP Soc Investigat Dermatol C1 [Zhai, Z.; Liu, W.; Kaur, M.; Luo, Y.; Norris, D.; Fujita, M.] Univ Colorado AMC, Dermatol, Aurora, CO USA. [Spritz, R. A.; Dinarello, C. A.] Univ Colorado AMC, Med, Aurora, CO USA. [Norris, D.; Fujita, M.] Denver VA Med Ctr, Denver, CO USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0022-202X EI 1523-1747 J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD MAY PY 2015 VL 135 SU 1 MA 640 BP S110 EP S110 PG 1 WC Dermatology SC Dermatology GA CF8CO UT WOS:000352783200640 ER PT J AU Muram, D Matsumoto, A Zhang, X Cui, Z AF Muram, D. Matsumoto, A. Zhang, X. Cui, Z. TI APPLICATION OF THE ENDOCRINE SOCIETY CLINICAL GUIDELINES ON TESTOSTERONE THERAPY IN MEN WITH ANDROGEN DEFICIENCY SYNDROMES IN CLINICAL PRACTICE SO JOURNAL OF SEXUAL MEDICINE LA English DT Meeting Abstract C1 [Muram, D.; Zhang, X.; Cui, Z.] Lilly Res Labs, Indianapolis, IN USA. [Matsumoto, A.] VA Puget Sound Hlth Care Syst, Geriatr Res Educ & Clin Ctr, Seattle, WA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1743-6095 EI 1743-6109 J9 J SEX MED JI J. Sex. Med. PD MAY PY 2015 VL 12 SU 2 SI SI MA 035 BP 113 EP 113 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA CF8EQ UT WOS:000352789100036 ER PT J AU Hoggatt, KJ Williams, EC Der-Martirosian, C Yano, EM Washington, DL AF Hoggatt, Katherine J. Williams, Emily C. Der-Martirosian, Claudia Yano, Elizabeth M. Washington, Donna L. TI National Prevalence and Correlates of Alcohol Misuse in Women Veterans SO JOURNAL OF SUBSTANCE ABUSE TREATMENT LA English DT Article DE Alcohol misuse; Mental health care; Health services; Women veterans ID POSTTRAUMATIC-STRESS-DISORDER; IDENTIFICATION TEST AUDIT; US GENERAL-POPULATION; PRIMARY-CARE; MENTAL-HEALTH; SCREENING SCORES; AFGHANISTAN VETERANS; MILITARY ENVIRONMENT; GENDER-DIFFERENCES; AFFAIRS PATIENTS AB Our goal was to estimate the prevalence and correlates of alcohol misuse in women veterans and to assess the associations between alcohol misuse and mental health (MH) care utilization in a group comprising both Veterans Health Administration (VA) healthcare system users and non-users. We assessed alcohol misuse using survey-based AUDIT-C scores. The prevalence of alcohol misuse was 27% in VA users and 32% in nonusers. Prevalence rates were higher for VA users who were younger, served in OEF/OIF, or had combat exposure and for VA non-users who screened positive for posttraumatic stress disorder or sexual assault in the military. In contrast to VA users, VA non-users with alcohol misuse had a low prevalence of past-year MH care despite having indications of MH care need. Our results on alcohol misuse prevalence, its correlates, and its association with MH care may aid program planning and resource allocation in VA and non-VA settings. Published by Elsevier Inc. C1 [Hoggatt, Katherine J.; Yano, Elizabeth M.; Washington, Donna L.] Ctr Study Healthcare Innovat Implementat & Policy, VA Greater Los Angeles Hlth Serv Res & Dev HSR&D, Sepulveda, CA 91343 USA. [Hoggatt, Katherine J.] Univ Calif Los Angeles, Dept Epidemiol, Fielding Sch Publ Hlth, Los Angeles, CA USA. [Williams, Emily C.] VA Puget Sound, HSR&D, Denver Seattle Ctr Innovat Vet Ctr & Value Driven, Seattle, WA USA. [Williams, Emily C.] Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA. [Der-Martirosian, Claudia] VEMEC, North Hills, CA USA. [Yano, Elizabeth M.] Univ Calif Los Angeles, Dept Hlth Policy & Management, Fielding Sch Publ Hlth, Los Angeles, CA USA. [Washington, Donna L.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA. RP Hoggatt, KJ (reprint author), Ctr Study Healthcare Innovat Implementat & Policy, VA Greater Los Angeles Hlth Serv Res & Dev HSR&D, 16111 Plummer St 152, Sepulveda, CA 91343 USA. EM khoggatt@ucla.edu FU Department of Veterans Affairs (VA) Women's Health Services within the Office of Patient Care Services; VA Health Services Research and Development (HSRD) Service [SDR-08-270]; VA HSR&D Quality Enhancement Research Initiative (QUERI) Career Development Award [CDA 11-261]; VA Office of Academic Affiliations; VA HSR&D Senior Research Career Scientist award [RCS 05-195]; Career Development Award from VA HSRD [CDA 12-276]; National Institute of Mental Health [R25 MH080916-01A2]; Department of Veterans Affairs, HSRD QUERI FX This study was funded by the Department of Veterans Affairs (VA) Women's Health Services within the Office of Patient Care Services, and the VA Health Services Research and Development (HSR&D) Service (#SDR-08-270). Dr. Hoggatt was funded through a VA HSR&D Quality Enhancement Research Initiative (QUERI) Career Development Award (CDA 11-261) and received additional support from the VA Office of Academic Affiliations. Dr. Yano was funded through a VA HSR&D Senior Research Career Scientist award (RCS 05-195). Dr. Williams is supported by a Career Development Award from VA HSR&D (CDA 12-276) and is an investigator with the Implementation Research Institute (IRI) at the George Warren Brown School of Social Work at Washington University in St. Louis. IRI is supported through an award from the National Institute of Mental Health (R25 MH080916-01A2) and the Department of Veterans Affairs, HSR&D QUERI. The authors gratefully acknowledge Mark Canning for project management, and Su Sun Mor, MPH and Michael Mitchell, PhD, for assistance with database construction. Select results were previously presented at the Addiction Health Services Conference (Fairfax, VA; 2011). The views expressed within are solely those of the authors, and do not necessarily represent the views of the Department of Veterans Affairs or of the United States government. NR 51 TC 4 Z9 4 U1 1 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0740-5472 J9 J SUBST ABUSE TREAT JI J. Subst. Abus. Treat. PD MAY PY 2015 VL 52 BP 10 EP 16 DI 10.1016/j.jsat.2014.12.003 PG 7 WC Psychology, Clinical; Substance Abuse SC Psychology; Substance Abuse GA CF6OA UT WOS:000352674800002 PM 25661517 ER PT J AU Brody, AL McClernon, FJ AF Brody, Arthur L. McClernon, Francis Joseph TI Prediction of Smoking Cessation with Treatment: The Emerging Contribution of Brain Imaging Research SO NEUROPSYCHOPHARMACOLOGY LA English DT Editorial Material ID STIMULATION C1 [Brody, Arthur L.] Univ Calif Los Angeles, Dept Psychiat, Los Angeles, CA 90095 USA. [Brody, Arthur L.] VA Greater Los Angeles Healthcare Syst, Dept Psychiat, Los Angeles, CA USA. [Brody, Arthur L.] VA Greater Los Angeles Healthcare Syst, Dept Res, Los Angeles, CA USA. [McClernon, Francis Joseph] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC USA. RP Brody, AL (reprint author), Univ Calif Los Angeles, Dept Psychiat, 300 UCLA Med Plaza,Suite 2200, Los Angeles, CA 90095 USA. EM abrody@ucla.edu FU CSRD VA [I01 CX000412]; NIDA NIH HHS [P50 DA027840, R01 DA025876, R01 DA038442, R01 DA20872] NR 6 TC 1 Z9 1 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0893-133X EI 1740-634X J9 NEUROPSYCHOPHARMACOL JI Neuropsychopharmacology PD MAY PY 2015 VL 40 IS 6 BP 1309 EP 1310 DI 10.1038/npp.2015.31 PG 2 WC Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA CG0PI UT WOS:000352968100001 PM 25868069 ER PT J AU Basu, P Shah, NJ John, N Perez, A Gress, FG AF Basu, Patrick Shah, Niraj J. John, Nimy Perez, Audrik Gress, Frank G. TI Novel Colonoscopy Preparation of Organic Coconut Water With MiraLAX and Dulcolax in Split Doses for Decompensated Cirrhotics. a Randomized Double Blinded Open Labelled Clinical Pilot Single Centered Observational Study. Cosmic Study SO GASTROINTESTINAL ENDOSCOPY LA English DT Meeting Abstract C1 [Basu, Patrick; Gress, Frank G.] Columbia Univ Phys & Surg, New York, NY USA. [Basu, Patrick; John, Nimy; Perez, Audrik] Kings Cty Hosp, Med Ctr, Brooklyn, NY USA. [Shah, Niraj J.] Icahn Sch Med Mt Sinai, James J Peters VA Med Ctr, New York, NY 10029 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0016-5107 EI 1097-6779 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD MAY PY 2015 VL 81 IS 5 SU S MA Su1534 BP AB318 EP AB319 PG 5 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA V47DB UT WOS:000209931400232 ER PT J AU Childers, RE Williams, JL Sonnenberg, A AF Childers, Ryan E. Williams, Jeffrey L. Sonnenberg, Amnon TI Colonoscopy Sedation Trends in the United States: More for Women, Less for Ethnic Minorities and the Elderly SO GASTROINTESTINAL ENDOSCOPY LA English DT Meeting Abstract CT 46th Annual Digestive Diseases Week (DDW) / Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Annual Meeting of the American-Society-for-Gastrointestinal-Endoscopy (ASGE) CY MAY 16-19, 2015 CL Washington, DC SP Amer Assoc Study Liver Dis, Amer Gastroenterol Assoc, Amer Soc Gastrointestinal Endoscopy, Soc Surg Alimentary Tract C1 [Childers, Ryan E.; Williams, Jeffrey L.; Sonnenberg, Amnon] Oregon Hlth & Sci Univ, Gastroenterol, Lake Oswego, OR USA. [Sonnenberg, Amnon] Portland VA Med Ctr, Portland, OR USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0016-5107 EI 1097-6779 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD MAY PY 2015 VL 81 IS 5 SU S MA Sa1434 BP AB214 EP AB214 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA DS4PS UT WOS:000380763600244 ER PT J AU Chu, VW Li, EH Cheung, ML Ng, CKM Ho, SCP Luk, W Lai, S Leung, FW AF Chu, Virginia Wy Li, Ernest H. Cheung, Mabel L. Ng, Carmen Ka Man Ho, Steven C. P. Luk, Wf Lai, St Leung, Felix W. TI Water Exchange Colonoscopy Reduced Sedation Requirement Without Compromising Success of Cecal Intubation in Patients Accepting the Option of on Demand Sedation in Chinese Patients in Hong Kong SO GASTROINTESTINAL ENDOSCOPY LA English DT Meeting Abstract CT 46th Annual Digestive Diseases Week (DDW) / Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Annual Meeting of the American-Society-for-Gastrointestinal-Endoscopy (ASGE) CY MAY 16-19, 2015 CL Washington, DC SP Amer Assoc Study Liver Dis, Amer Gastroenterol Assoc, Amer Soc Gastrointestinal Endoscopy, Soc Surg Alimentary Tract C1 [Chu, Virginia Wy; Li, Ernest H.; Cheung, Mabel L.; Ng, Carmen Ka Man; Ho, Steven C. P.; Luk, Wf; Lai, St] Princess Margaret Hosp, Med & Geriatr, Kowloon, Hong Kong, Peoples R China. [Leung, Felix W.] Vet Affairs Greater Los Angeles Hlth Care Syst, Sepulveda Ambulatory Care Ctr, North Hills, CA USA. [Leung, Felix W.] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0016-5107 EI 1097-6779 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD MAY PY 2015 VL 81 IS 5 SU S MA Sa1439 BP AB216 EP AB217 PG 4 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA DS4PS UT WOS:000380763600249 ER PT J AU Makarov, DV Soulos, PR Gold, HT Yu, JB Sen, S Ross, JS Gross, CP AF Makarov, Danil V. Soulos, Pamela R. Gold, Heather T. Yu, James B. Sen, Sounok Ross, Joseph S. Gross, Cary P. TI Regional-Level Correlations in Inappropriate Imaging Rates for Prostate and Breast Cancers Potential Implications for the Choosing Wisely Campaign SO JAMA ONCOLOGY LA English DT Article ID TOP 5 LIST; MEDICARE POPULATION; CARE; TRENDS; VISUALIZATION; APPROPRIATE; PROGRESS; OVERUSE; COSTS; RISK AB IMPORTANCE The association between regional norms of clinical practice and appropriateness of care is incompletely understood. Understanding regional patterns of care across diseases might optimize implementation of programs like Choosing Wisely, an ongoing campaign to decrease wasteful medical expenditures. OBJECTIVE To determine whether regional rates of inappropriate prostate and breast cancer imaging were associated. DESIGN, SETTING, AND PARTICIPANTS Retrospective cohort study using the the Surveillance, Epidemiology, and End Results-Medicare linked database. We identified patients diagnosed from 2004 to 2007 with low-risk prostate (clinical stage T1c/T2a; Gleason score, <= 6; and prostate-specific antigen level, <10 ng/mL) or breast cancer (in situ, stage I, or stage II disease), based on Choosing Wisely definitions. MAIN OUTCOMES AND MEASURES In a hospital referral region (HRR)-level analysis, our dependent variable was HRR-level imaging rate among patients with low-risk prostate cancer. Our independent variable was HRR-level imaging rate among patients with low-risk breast cancer. In a subsequent patient-level analysis we used multivariable logistic regression to model prostate cancer imaging as a function of regional breast cancer imaging and vice versa. RESULTS We identified 9219 men with prostate cancer and 30 398 women with breast cancer residing in 84 HRRs. We found high rates of inappropriate imaging for both prostate cancer (44.4%) and breast cancer (41.8%). In the first, second, third, and fourth quartiles of breast cancer imaging, inappropriate prostate cancer imaging was 34.2%, 44.6%, 41.1%, and 56.4%, respectively. In the first, second, third, and fourth quartiles of prostate cancer imaging, inappropriate breast cancer imaging was 38.1%, 38.4%, 43.8%, and 45.7%, respectively. At the HRR level, inappropriate prostate cancer imaging rates were associated with inappropriate breast cancer imaging rates (rho=0.35; P<.01). At the patient level, a man with low-risk prostate cancer had odds ratios (95% CIs) of 1.72 (1.12-2.65), 1.19 (0.78-1.81), or 1.76 (1.15-2.70) for undergoing inappropriate prostate imaging if he lived in an HRR in the fourth, third, or second quartiles, respectively, of inappropriate breast cancer imaging, compared with the lowest quartile. CONCLUSIONS AND RELEVANCE At a regional level, there is an association between inappropriate prostate and breast cancer imaging rates. This finding suggests the existence of a regional-level propensity for inappropriate imaging utilization, which may be considered by policymakers seeking to improve quality of care and reduce health care spending in high-utilization areas. C1 [Makarov, Danil V.] US Dept Vet Affairs, Washington, DC USA. [Makarov, Danil V.] NYU, Sch Med, Dept Urol, New York, NY 10003 USA. [Makarov, Danil V.; Gold, Heather T.] NYU, Sch Med, Dept Populat Hlth, New York, NY USA. [Makarov, Danil V.; Gold, Heather T.] NYU, Inst Canc, New York, NY USA. [Soulos, Pamela R.; Yu, James B.; Sen, Sounok; Gross, Cary P.] Yale Univ, Canc Outcomes Publ Policy & Effectiveness Res COP, New Haven, CT USA. [Soulos, Pamela R.; Gold, Heather T.] Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06510 USA. [Gold, Heather T.] NYU, Sch Med, Dept Med, New York, NY USA. [Yu, James B.] Yale Univ, Sch Med, Dept Therapeut Radiol, New Haven, CT 06510 USA. [Ross, Joseph S.] Yale New Haven Med Ctr, Ctr Outcomes Res & Evaluat, New Haven, CT 06504 USA. [Ross, Joseph S.] Yale Univ, Sch Med, Dept Med, Gen Internal Med Sect, New Haven, CT 06510 USA. [Ross, Joseph S.] Yale Univ, Dept Hlth Policy & Management, Sch Publ Hlth, New Haven, CT USA. [Gross, Cary P.] Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06510 USA. RP Makarov, DV (reprint author), NYU, Sch Med, 550 First Ave,VZ30 Sixth Floor,Off 613, New York, NY 10016 USA. EM danil.makarov@nyumc.org OI Makarov, Danil/0000-0002-0565-9272 FU Robert Wood Johnson Foundation; Louis Feil Charitable Lead Trust; US Department of Veterans Affairs (VA); Veterans Health Administration; Health Services Research & Development Service (HSRDS); VA HSR&DS Career Development awardee at the Manhattan VA; California Department of Public Health [103885]; National Cancer Institute (NCI) SEER Program [N01-PC-35136, N01-PC-35139, N02-PC-15105]; Centers for Disease Control and Prevention (CDC) National Program of Cancer Registries [U55/CCR921930-02]; Centers for Medicare & Medicaid Services; National Institute on Aging [K08 AG032886]; American Federation for Aging Research through the Paul B. Beeson Career Development Award Program FX This research was supported by the Robert Wood Johnson Foundation, The Louis Feil Charitable Lead Trust, and the US Department of Veterans Affairs (VA), Veterans Health Administration, Health Services Research & Development Service (HSR&DS). Dr Makarov is a VA HSR&DS Career Development awardee at the Manhattan VA. The collection of the California cancer incidence data used in this study was supported by the California Department of Public Health as part of the statewide cancer reporting program mandated by California Health and Safety Code Section 103885; the National Cancer Institute (NCI) SEER Program under contract N01-PC-35136 awarded to the Northern California Cancer Center, contract N01-PC-35139 awarded to the University of Southern California, and contract N02-PC-15105 awarded to the Public Health Institute; and the Centers for Disease Control and Prevention (CDC) National Program of Cancer Registries, under agreement U55/CCR921930-02 awarded to the Public Health Institute. Dr Ross receives research support from the Centers for Medicare & Medicaid Services, to develop and maintain performance measures that are used for public reporting, and from the US Food and Drug Administration, to develop methods for postmarket surveillance of medical devices. Dr Ross is also supported by grant K08 AG032886 from the National Institute on Aging and by the American Federation for Aging Research through the Paul B. Beeson Career Development Award Program. NR 32 TC 11 Z9 11 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA EI 2374-2445 J9 JAMA ONCOL JI JAMA Oncol. PD MAY PY 2015 VL 1 IS 2 BP 185 EP 194 DI 10.1001/jamaoncol.2015.37 PG 10 WC Oncology SC Oncology GA DW5FK UT WOS:000383668400012 PM 26181021 ER PT J AU Hamilton, J Li, J Wu, Q Yang, PA Luo, B Li, H Bradley, J Taylor, J Randall, T Mountz, J Hsu, HC AF Hamilton, Jennie Li, Jun Wu, Qi Yang, PingAr Luo, Bao Li, Hao Bradley, John Taylor, Justin Randall, Troy Mountz, John Hsu, Hui-Chen TI Increased PKC signaling in lupus La reactive B cells promotes development of the transitional T3 population and memory B cells in autoimmune BXD2 mice SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract CT Annual Meeting of the American-Association-of-Immunologists (IMMUNOLOGY) CY MAY 08-12, 2015 CL New Orleans, LA SP Amer Assoc Immunologists C1 [Hamilton, Jennie; Li, Jun; Wu, Qi; Yang, PingAr; Luo, Bao; Li, Hao; Bradley, John; Randall, Troy; Mountz, John; Hsu, Hui-Chen] Univ Alabama Birmingham, Dept Med, Div Clin Immunol & Rheumatol, Birmingham, AL 35294 USA. [Taylor, Justin] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USA. [Mountz, John] Birmingham VA Med Ctr, Dept Med, Birmingham, AL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 EI 1550-6606 J9 J IMMUNOL JI J. Immunol. PD MAY 1 PY 2015 VL 194 SU 1 MA BA3P.108 PG 2 WC Immunology SC Immunology GA DQ7RG UT WOS:000379404500233 ER PT J AU Kaplan, D Chang, LY Tanoue, S Li, YH AF Kaplan, David Chang, Li-Yuan Tanoue, Shiroh Li, Yonghai TI Increased sensitivity of peripheral CD27(+) memory B cells to Fas-induced apoptosis contributes to their disappearance in cirrhosis SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract CT Annual Meeting of the American-Association-of-Immunologists (IMMUNOLOGY) CY MAY 08-12, 2015 CL New Orleans, LA SP Amer Assoc Immunologists C1 [Kaplan, David] Philadelphia Vet Affairs Med Ctr, Med, Philadelphia, PA USA. [Kaplan, David; Chang, Li-Yuan; Tanoue, Shiroh; Li, Yonghai] Univ Penn, Gastroenterol, Philadelphia, PA 19104 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 EI 1550-6606 J9 J IMMUNOL JI J. Immunol. PD MAY 1 PY 2015 VL 194 SU 1 MA HUM1P.309 PG 2 WC Immunology SC Immunology GA DQ7RG UT WOS:000379404500309 ER PT J AU Mountz, J Li, H Hsu, HC Zhou, Y Wu, Q Yang, PA Li, J Luo, B Morel, L Ware, C Fu, Y Yagita, H AF Mountz, John Li, Hao Hsu, Hui-Chen Zhou, Yong Wu, Qi Yang, PingAr Li, Jun Luo, Bao Morel, Laurence Ware, Carl Fu, Yang Yagita, Hideo TI Type I interferons promote lupus through disruption of the lymphotoxin receptor mediated mechanosensing MKL1 pathway in marginal zone macrophages SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract CT Annual Meeting of the American-Association-of-Immunologists (IMMUNOLOGY) CY MAY 08-12, 2015 CL New Orleans, LA SP Amer Assoc Immunologists C1 [Mountz, John; Li, Hao; Hsu, Hui-Chen; Zhou, Yong; Wu, Qi; Yang, PingAr; Li, Jun; Luo, Bao] Univ Alabama Birmingham, Birmingham, AL USA. [Morel, Laurence] Univ Florida, Dept Pathol Immunol & Lab Med, Gainesville, FL USA. [Fu, Yang] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA. [Ware, Carl] Sanford Burnham Med Res Inst La Jolla, Infect & Inflammatory Dis Ctr, La Jolla, CA USA. [Mountz, John] Birmingham VAMC, Birmingham, AL USA. [Yagita, Hideo] Juntendo Univ, Sch Med, Dept Immunol, Tokyo, Japan. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 EI 1550-6606 J9 J IMMUNOL JI J. Immunol. PD MAY 1 PY 2015 VL 194 SU 1 MA BA4P.124 PG 1 WC Immunology SC Immunology GA DQ7RG UT WOS:000379404503081 ER PT J AU Narang, A Qiao, F Atkinson, C Kulik, L Holers, V Yang, XF Tomlinson, S AF Narang, Aarti Qiao, Fei Atkinson, Carl Kulik, Liudmila Holers, V. Yang, Xiaofeng Tomlinson, Stephen TI Targeted complement inhibition improves recovery in murine spinal cord injury model SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract CT Annual Meeting of the American-Association-of-Immunologists (IMMUNOLOGY) CY MAY 08-12, 2015 CL New Orleans, LA SP Amer Assoc Immunologists C1 [Narang, Aarti; Qiao, Fei; Atkinson, Carl; Yang, Xiaofeng; Tomlinson, Stephen] Med Univ S Carolina, Microbiol & Immunol, Charleston, SC 29425 USA. [Kulik, Liudmila; Holers, V.] Univ Colorado, SOM MED, Denver, CO 80202 USA. [Tomlinson, Stephen] Ralph H Johnson VA Med Ctr, Charleston, SC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 EI 1550-6606 J9 J IMMUNOL JI J. Immunol. PD MAY 1 PY 2015 VL 194 SU 1 MA THER2P.956 PG 2 WC Immunology SC Immunology GA DQ7RG UT WOS:000379404500016 ER PT J AU Richard, ML Brandon, D Sato, S Zhang, X AF Richard, Mara Lennard Brandon, Danielle Sato, Shuzo Zhang, Xian TI Regulation of granulocyte colony stimulating factor by Fli-1, a novel transcriptional activator of inflammatory mediators SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract CT Annual Meeting of the American-Association-of-Immunologists (IMMUNOLOGY) CY MAY 08-12, 2015 CL New Orleans, LA SP Amer Assoc Immunologists C1 [Richard, Mara Lennard; Brandon, Danielle; Sato, Shuzo; Zhang, Xian] Med Univ South Carolina, Charleston, SC USA. [Zhang, Xian] Ralph H Johnson Vet Affairs Med Ctr, Med Res Serv, Charleston, SC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 EI 1550-6606 J9 J IMMUNOL JI J. Immunol. PD MAY 1 PY 2015 VL 194 SU 1 MA CCR3P.213 PG 1 WC Immunology SC Immunology GA DQ7RG UT WOS:000379404502297 ER PT J AU Marx, N Rosenstock, J Kahn, SE Zinman, B Kastelein, JJ Lachin, JM Espeland, MA Bluhmki, E Mattheus, M Ryckaert, B Patel, S Johansen, OE Woerle, HJ AF Marx, Nikolaus Rosenstock, Julio Kahn, Steven E. Zinman, Bernard Kastelein, John J. Lachin, John M. Espeland, Mark A. Bluhmki, Erich Mattheus, Michaela Ryckaert, Bart Patel, Sanjay Johansen, Odd Erik Woerle, Hans-Juergen TI Design and baseline characteristics of the CARdiovascular Outcome Trial of LINAgliptin Versus Glimepiride in Type 2 Diabetes (CAROLINA (R)) SO DIABETES & VASCULAR DISEASE RESEARCH LA English DT Article DE Type 2 diabetes; cardiovascular complications; macrovascular; dipeptidyl-peptidase-4 inhibitor; sulphonylurea ID DPP-4 INHIBITION; CLINICAL-TRIALS; IV INHIBITORS; DOUBLE-BLIND; COMPLICATIONS; METAANALYSIS; RATIONALE; SAFETY; DRUGS AB CARdiovascular Outcome Trial of LINAgliptin Versus Glimepiride in Type 2 Diabetes (NCT01243424) is an ongoing, randomized trial in subjects with early type 2 diabetes and increased cardiovascular risk or established complications that will determine the long-term cardiovascular impact of linagliptin versus the sulphonylurea glimepiride. Eligible patients were sulphonylurea-naive with HbA(1c) 6.5%-8.5% or previously exposed to sulphonylurea (in monotherapy or in a combination regimen <5years) with HbA(1c) 6.5%-7.5%. Primary outcome is time to first occurrence of cardiovascular death, non-fatal myocardial infarction, non-fatal stroke or hospitalization for unstable angina. A total of 631 patients with primary outcome events will be required to provide 91% power to demonstrate non-inferiority in cardiovascular safety by comparing the upper limit of the two-sided 95% confidence interval as being below 1.3 for a given hazard ratio. Hierarchical testing for superiority will follow, and the trial has 80% power to demonstrate a 20% relative cardiovascular risk reduction. A total of 6041 patients were treated with median type 2 diabetes duration 6.2years, 40.0% female, mean HbA1c 7.2%, 66% on 1 and 24% on 2 glucose-lowering agents and 34.5% had previous cardiovascular complications. The results of CARdiovascular Outcome Trial of LINAgliptin Versus Glimepiride in Type 2 Diabetes may influence the decision-making process for selecting a second glucose-lowering agent after metformin in type 2 diabetes. C1 [Marx, Nikolaus] Univ Hosp Aachen, Dept Internal Med 1, D-52074 Aachen, Germany. [Rosenstock, Julio] Dallas Diabet & Endocrine Ctr Med City, Dallas, TX USA. [Rosenstock, Julio] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA. [Kahn, Steven E.] VA Puget Sound Hlth Care Syst, Dept Med, Div Metab Endocrinol & Nutr, Seattle, WA USA. [Kahn, Steven E.] Univ Washington, Seattle, WA 98195 USA. [Zinman, Bernard] Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada. [Zinman, Bernard] Univ Toronto, Toronto, ON, Canada. [Kastelein, John J.] Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, NL-1105 AZ Amsterdam, Netherlands. [Lachin, John M.] George Washington Univ, Biostat Ctr, Rockville, MD USA. [Espeland, Mark A.] Wake Forest Baptist Med Ctr, Dept Biostat, Winston Salem, NC USA. [Bluhmki, Erich] Boehringer Ingelheim GmbH & Co KG, Biberach, Germany. [Mattheus, Michaela; Woerle, Hans-Juergen] Boehringer Ingelheim KG, Ingelheim, Germany. [Ryckaert, Bart] Boehringer Ingelheim GmbH & Co KG, Brussels, Belgium. [Patel, Sanjay] Boehringer Ingelheim GmbH & Co KG, Bracknell, Berks, England. [Johansen, Odd Erik] Boehringer Ingelheim GmbH & Co KG, Asker, Norway. RP Marx, N (reprint author), Univ Hosp Aachen, Dept Internal Med 1, D-52074 Aachen, Germany. EM nmarx@ukaachen.de RI Zinman, Bernard/E-7266-2013 FU Boehringer Ingelheim; Eli Lilly FX The CAROLINA trial is sponsored by Boehringer Ingelheim and Eli Lilly. NR 23 TC 33 Z9 33 U1 2 U2 7 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1479-1641 EI 1752-8984 J9 DIABETES VASC DIS RE JI Diabetes Vasc. Dis. Res. PD MAY PY 2015 VL 12 IS 3 BP 164 EP 174 DI 10.1177/1479164115570301 PG 11 WC Endocrinology & Metabolism; Peripheral Vascular Disease SC Endocrinology & Metabolism; Cardiovascular System & Cardiology GA CF6EM UT WOS:000352649600002 PM 25780262 ER PT J AU Ioannou, GN Bryson, CL Weiss, NS Boyko, EJ AF Ioannou, George N. Bryson, Christopher L. Weiss, Noel S. Boyko, Edward J. TI Associations between lipodystrophy or antiretroviral medications and cirrhosis in patients with HIV infection or HIV/HCV coinfection SO EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY LA English DT Article DE adverse effect; AIDS; drug; fibrosis; side effect ID HEPATITIS-C VIRUS; THERAPY-ASSOCIATED LIPODYSTROPHY; HEPATOCELLULAR-CARCINOMA; RISK-FACTORS; FAT LOSS; LIVER; INDIVIDUALS; LIPOATROPHY; PROGRESSION; METABOLISM AB Background Many HIV antiretroviral medications have been associated with chronic liver injury. HIV-infected patients frequently develop HIV and highly active antiretroviral treatment-associated lipodystrophy syndrome (HALS), characterized by accumulation of intra-abdominal fat, insulin resistance, and hepatic steatosis. We sought to determine whether long-term exposure to specific antiretroviral medications or the presence of HALS predispose HIV-infected patients to the development of cirrhosis. Methods HIV-infected patients with cirrhosis who received care in the Veterans Affairs Healthcare System nationally in 2009 were matched by hepatitis C virus (HCV) coinfection status and year of first visit for HIV to the Veterans Affairs Healthcare System with HIV-infected patients without cirrhosis in a 1 : 3 ratio. Results Among HIV/HCV coinfected patients (593 with cirrhosis and 1591 matched controls), HALS was associated with a significantly increased risk for cirrhosis (adjusted odds ratio 1.6, 95% confidence interval 1.1-2.3), especially among Black patients (adjusted odds ratio 2.9, 95% confidence interval 1.6-5.2). In addition, among HIV/HCV coinfected patients, longer cumulative exposures to all antiretroviral medications, all nucleoside reverse transcriptase inhibitors, all protease inhibitors, and selected individual medications (didanosine, stavudine, and nelfinavir) were found to be significantly associated with cirrhosis. In contrast, among HIV-infected patients not coinfected with HCV (245 with cirrhosis and 658 matched controls), HALS or exposure to antiretroviral medications was found not to be significantly associated with cirrhosis, with the exception of didanosine. Conclusion HALS and cumulative exposure to nucleoside reverse transcriptase inhibitors and protease inhibitors, especially stavudine, didanosine, and nelfinavir, were found to be associated with the development of cirrhosis in HIV/HCV coinfected patients, but not in HIV-monoinfected patients. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved. C1 [Ioannou, George N.] Vet Affairs Puget Sound Healthcare Syst, Div Gastroenterol, Seattle, WA 98108 USA. [Bryson, Christopher L.; Boyko, Edward J.] Vet Affairs Puget Sound Healthcare Syst, Div Internal Med, Seattle, WA 98108 USA. [Weiss, Noel S.] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA. RP Ioannou, GN (reprint author), Vet Affairs Puget Sound Healthcare Syst, Div Gastroenterol, S-111 Gastro,1660 S Columbian Way, Seattle, WA 98108 USA. EM georgei@medicine.washington.edu OI Boyko, Edward/0000-0002-3695-192X FU Merit Review grant, Clinical Science Research and Development, Office of Research and Development, Veterans Affairs [I01CX000320] FX The study was funded by a Merit Review grant (I01CX000320), Clinical Science Research and Development, Office of Research and Development, Veterans Affairs (G.N.I.). NR 28 TC 1 Z9 1 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0954-691X EI 1473-5687 J9 EUR J GASTROEN HEPAT JI Eur. J. Gastroenterol. Hepatol. PD MAY PY 2015 VL 27 IS 5 BP 577 EP 584 DI 10.1097/MEG.0000000000000290 PG 8 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA CE9KK UT WOS:000352162600015 PM 25769096 ER PT J AU Murray, SS Wang, JC Duarte, MEL Zhao, KW Tian, HJ Francis, T Murray, EJB AF Murray, Samuel S. Wang, Jeffrey C. Leite Duarte, Maria Eugenia Zhao, Ke-Wei Tian, Haijun Francis, Timothy Murray, Elsa J. Brochmann TI The bone matrix protein secreted phosphoprotein 24 kD (Spp24): bone metabolism regulator and starting material for biotherapeutic materials SO HISTOLOGY AND HISTOPATHOLOGY LA English DT Review DE Secreted phosphoprotein 24 kD; Spp24; SPP2; Bone morphogenetic protein; Bone matrix proteins ID GROWTH-FACTOR-BETA; HORMONE GH ACTION; BINDING PEPTIDE; RODENT MODEL; CYSTATIN SUPERFAMILY; RESPONSE GENE; EXPRESSION; SEQUENCE; REVEALS; COMPLEX AB Secreted phosphoprotein 24 kD (Spp24) is a bone matrix protein that appears to be derived primarily from the liver and delivered to other tissues in a protective complex. A significant role in bone growth and turnover is suggested by genetic studies that associate the gene locus (SPP2) with bone mineral density and bone quality. The function of this protein in the normal bone environment is unknown but clues are given by the fact that Spp24, or proteolytic products of Spp24, bind cytokines of the TGF-beta superfamily and also activate intracellular signaling pathways. Several potential biotherapeutics have been engineered from this protein including materials that enhance BMP-induced bone healing and, on the other hand, materials that inhibit BMPs in clinical situations where this is called for such as reducing BMP-induced inflammation and inhibiting tumors dependent on BMP autocrine systems. As understanding of the structure and function of this protein increases, more opportunities for rationally developed therapeutics will become apparent. C1 [Murray, Samuel S.; Murray, Elsa J. Brochmann] VA Greater Los Angeles, Sepulveda Ambulatory Care Ctr, Geriatr Res Educ & Clin Ctr, Los Angeles, CA USA. [Murray, Samuel S.; Murray, Elsa J. Brochmann] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA. [Wang, Jeffrey C.] Univ So Calif, Dept Orthopaed Surg, Los Angeles, CA USA. [Leite Duarte, Maria Eugenia] Natl Inst Traumatol & Orthopaed INTO, Rio De Janeiro, Brazil. [Leite Duarte, Maria Eugenia] Fed Univ Rio Janeiro UFRJ, Rio De Janeiro, Brazil. [Zhao, Ke-Wei] VA Greater Los Angeles, Res Serv, Los Angeles, CA USA. [Tian, Haijun] Second Mil Med Univ, Shanghai Changzheng Hosp, Dept Orthopaed Surg, Shanghai, Peoples R China. [Francis, Timothy] Coventry Univ, Business Dev Grp, Coventry, W Midlands, England. RP Murray, SS (reprint author), VA Med Ctr, GRECC 11-E,16111 Plummer St, Sepulveda, CA 91343 USA. EM samuel.murray@va.gov FU Research Service of the Department of Veterans Affairs, USA FX Supported by the Research Service of the Department of Veterans Affairs, USA NR 37 TC 4 Z9 4 U1 0 U2 5 PU F HERNANDEZ PI MURCIA PA PLAZA FUENSANTA 2-7 C, 30008 MURCIA, SPAIN SN 0213-3911 EI 1699-5848 J9 HISTOL HISTOPATHOL JI Histol. Histopath. PD MAY PY 2015 VL 30 IS 5 BP 531 EP 537 DI 10.14670/HH-30.531 PG 7 WC Cell Biology; Pathology SC Cell Biology; Pathology GA CF4EA UT WOS:000352500300003 PM 25339413 ER PT J AU Ren, X Bischoff, D Weisgerber, DW Lewis, MS Tu, V Yamaguchi, DT Miller, TA Harley, BAC Lee, JC AF Ren, Xiaoyan Bischoff, David Weisgerber, Daniel W. Lewis, Michael S. Tu, Victor Yamaguchi, Dean T. Miller, Timothy A. Harley, Brendan A. C. Lee, Justine C. TI Osteogenesis on nanoparticulate mineralized collagen scaffolds via autogenous activation of the canonical BMP receptor signaling pathway SO BIOMATERIALS LA English DT Article DE Osteogenesis; Biomimetic material; Nanoparticulate mineralization; BMP ID BONE MORPHOGENETIC PROTEIN-2; MESENCHYMAL STEM-CELLS; CALCIUM-PHOSPHATE; CRANIAL DEFECTS; COMPOSITE; DIFFERENTIATION; COMPLICATIONS; CRANIOPLASTY; FUSION; FAMILY AB Skeletal regenerative medicine frequently incorporates deliverable growth factors to stimulate osteogenesis. However, the cost and side effects secondary to supraphysiologic dosages of growth factors warrant investigation of alternative methods of stimulating osteogenesis for clinical utilization. In this work, we describe growth factor independent osteogenic induction of human mesenchymal stem cells (hMSCs) on a novel nanoparticulate mineralized collagen glycosaminoglycan scaffold (MC-GAG). hMSCs demonstrated elevated osteogenic gene expression and mineralization on MC-GAG with minimal to no effect upon addition of BMP-2 when compared to non-mineralized scaffolds (Col-GAG). To investigate the intracellular pathways responsible for the increase in osteogenesis, we examined the canonical and non-canonical pathways downstream from BMP receptor activation. Constitutive Smad1/5 phosphorylation with nuclear translocation occurred on MC-GAG independent of BMP-2, whereas Smad1/5 phosphorylation depended on BMP-2 stimulation on Col-GAG. When non-canonical BMPR signaling molecules were examined, ERK1/2 phosphorylation was found to be decreased in MC-GAG but elevated in Col-GAG. No differences in Smad2/3 or p38 activation were detected. Collectively, these results demonstrated that MC-GAG scaffolds induce osteogenesis without exogenous BMP-2 addition via endogenous activation of the canonical BMP receptor signaling pathway. Published by Elsevier Ltd. C1 [Ren, Xiaoyan; Tu, Victor; Miller, Timothy A.; Lee, Justine C.] Univ Calif Los Angeles, David Geffen Sch Med, Div Plast & Reconstruct Surg, Los Angeles, CA 90095 USA. [Ren, Xiaoyan; Tu, Victor; Miller, Timothy A.; Lee, Justine C.] Greater Angeles VA Healthcare Syst, Div Plast & Reconstruct Surg, Los Angeles, CA 90073 USA. [Bischoff, David; Yamaguchi, Dean T.] Greater Angeles VA Healthcare Syst, Res Serv, Los Angeles, CA USA. [Weisgerber, Daniel W.; Harley, Brendan A. C.] Univ Illinois, Inst Genom Biol, Dept Chem & Biomol Engn, Urbana, IL 61801 USA. [Lewis, Michael S.] Greater Los Angeles VA Healthcare Syst, Dept Pathol, Los Angeles, CA USA. RP Lee, JC (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Div Plast & Reconstruct Surg, 200 UCLA Med Plaza,Suite 465, Los Angeles, CA 90095 USA. EM justine@ucla.edu OI Harley, Brendan/0000-0001-5458-154X FU Merit Review Grant - U.S. Department of Veterans Affairs [1I01BX001367-01A2]; Jean Perkins Foundation; National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health [R21 AR063331]; National Science Foundation (NSF) [0965918] FX This work was supported by a Merit Review Grant (1I01BX001367-01A2) awarded by the U.S. Department of Veterans Affairs (TAM) and the Jean Perkins Foundation (JCL). Research reported in this publication was also supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award Numbers R21 AR063331 (BACH). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. DWW was funded at UIUC from National Science Foundation (NSF) Grant 0965918 IGERT: Training the Next Generation of Researchers in Cellular & Molecular Mechanics and BioNanotechnology. NR 43 TC 12 Z9 13 U1 3 U2 38 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0142-9612 EI 1878-5905 J9 BIOMATERIALS JI Biomaterials PD MAY PY 2015 VL 50 BP 107 EP 114 DI 10.1016/j.biomaterials.2015.01.059 PG 8 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA CE2OX UT WOS:000351656000012 PM 25736501 ER PT J AU Schafer, AL Li, X Schwartz, AV Tufts, LS Wheeler, AL Grunfeld, C Stewart, L Rogers, SJ Carter, JT Posselt, AM Black, DM Shoback, DM AF Schafer, A. L. Li, X. Schwartz, A. V. Tufts, L. S. Wheeler, A. L. Grunfeld, C. Stewart, L. Rogers, S. J. Carter, J. T. Posselt, A. M. Black, D. M. Shoback, D. M. TI Changes in vertebral bone marrow fat and bone mass after gastric bypass surgery: A pilot study SO BONE LA English DT Article DE Bone marrow fat; Bariatric surgery; Gastric bypass surgery; Diabetes ID ADIPOSE-TISSUE; MINERAL DENSITY; WEIGHT-LOSS; CALORIC RESTRICTION; BARIATRIC SURGERY; ANOREXIA-NERVOSA; FRACTURE RISK; OLDER-ADULTS; WOMEN; DXA AB Bone marrow fat may serve a metabolic role distinct from other fat depots, and it may be altered by metabolic conditions including diabetes. Caloric restriction paradoxically increases marrow fat in mice, and women with anorexia nervosa have high marrow fat. The longitudinal effect of weight loss on marrow fat in humans is unknown. We hypothesized that marrow fat increases after Roux-en-Y gastric bypass (RYGB) surgery, as total body fat decreases. In a pilot study of 11 morbidly obese women (6 diabetic, 5 nondiabetic), we measured vertebral marrow fat content (percentage fat fraction) before and 6 months after RYGB using magnetic resonance spectroscopy. Total body fat mass declined in all participants (mean +/- SD decline 19.1 +/- 6.1 kg or 36.5% +/- 10.9%, p <0.001), Areal bone mineral density (BMD) decreased by 5.2% +/- 3.5% and 4.1% +/- 2.6% at the femoral neck and total hip, respectively, and volumetric BMD decreased at the spine by 7.4% +/- 2.8% (p <0.001 for all). Effects of RYGB on marrow fat differed by diabetes status (adjusted p = 0.04). There was little mean change in marrow fat in nondiabetic women (mean +0.9%, 95% Cl - 10.0 to + 11.7%, p = 0.84). In contrast, marrow fat decreased in diabetic women (-7.5%, 95% Cl - 152 to +0.1%, p = 0.05). Changes in total body fat mass and marrow fat were inversely correlated among nondiabetic (r = -0.96, p = 0.01) but not diabetic (r = 0.52, p = 0.29) participants. In conclusion, among those without diabetes, marrow fat is maintained on average after RYGB, despite dramatic declines in overall fat mass. Among those with diabetes, RYGB may reduce marrow fat. Thus, future studies of marrow fat should take diabetes status into account. Marrow fat may have unique metabolic behavior compared with other fat depots. Published by Elsevier Inc. C1 [Schafer, A. L.; Wheeler, A. L.; Grunfeld, C.; Shoback, D. M.] Univ Calif San Francisco, Dept Med, San Francisco, CA USA. [Li, X.; Tufts, L. S.] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA. [Schwartz, A. V.; Black, D. M.] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA. [Stewart, L.; Rogers, S. J.; Carter, J. T.; Posselt, A. M.] Univ Calif San Francisco, Dept Surg, San Francisco, CA USA. [Schafer, A. L.; Wheeler, A. L.; Grunfeld, C.; Shoback, D. M.] San Francisco VA Med Ctr, Med Serv, San Francisco, CA USA. [Stewart, L.] San Francisco VA Med Ctr, Surg Serv, San Francisco, CA USA. RP Schafer, AL (reprint author), 1700 Owens St,Room 367, San Francisco, CA 94158 USA. EM anne.schafer@ucsf.edu OI Wheeler, Amber/0000-0002-9926-1301 FU Department of Veterans Affairs, VHA, CSRD Service [CDA-2 5 IK2 CX000549-04]; UCSF Diabetes Center; National Center for Advancing Translational Science of the National Institutes of Health through UCSF-CTSI [UL1 TR000004]; NIH [5 K12 HD052163-15] FX Grant support: The research described here was supported by the Department of Veterans Affairs, VHA, CSR&D Service (CDA-2 5 IK2 CX000549-04, to ALS, SFVAMC) and by a pilot and feasibility grant with funds provided by the UCSF Diabetes Center. Additional support was provided by the National Center for Advancing Translational Science of the National Institutes of Health through UCSF-CTSI Grant UL1 TR000004, and by NIH grant 5 K12 HD052163-15. Manuscript contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. Calcium citrate supplements were supplied by Bariatric Advantage. NR 36 TC 18 Z9 18 U1 2 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 8756-3282 EI 1873-2763 J9 BONE JI Bone PD MAY PY 2015 VL 74 BP 140 EP 145 DI 10.1016/j.bone.2015.01.010 PG 6 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA CD6HE UT WOS:000351189400017 PM 25603463 ER PT J AU Wolkowitz, OM Mellon, SH Lindqvist, D Epel, ES Blackburn, EH Lin, J Reus, VI Burke, H Rosser, R Mahan, L Mackin, S Yang, T Weiner, M Mueller, S AF Wolkowitz, Owen M. Mellon, Synthia H. Lindqvist, Daniel Epel, Elissa S. Blackburn, Elizabeth H. Lin, Jue Reus, Victor I. Burke, Heather Rosser, Rebecca Mahan, Laura Mackin, Scott Yang, Tony Weiner, Michael Mueller, Susanne TI PBMC telomerase activity, but not leukocyte telomere length, correlates with hippocampal volume in major depression SO PSYCHIATRY RESEARCH-NEUROIMAGING LA English DT Article DE Telomeres; Telomerase; Hippocampus; Leukocytes; Brain; Depression ID SHORTER TELOMERES; BRAIN-INJURY; REVERSE-TRANSCRIPTASE; COGNITIVE PERFORMANCE; NEUROTROPHIC FACTOR; CATALYTIC SUBUNIT; EMERGING ROLES; T-LYMPHOCYTES; DNA-DAMAGE; STRESS AB Accelerated cell aging, indexed in peripheral leukocytes by telomere shortness and in peripheral blood mononuclear cells (PBMCs) by telomerase activity, has been reported in several studies of major depressive disorder (MDD). However, the relevance of these peripheral measures for brain indices that are presumably more directly related to MDD pathophysiology is unknown. In this study, we explored the relationship between PBMC telomerase activity and leukocyte telomere length and magnetic resonance imaging-estimated hippocampal volume in un-medicated depressed individuals and healthy controls. We predicted that to the extent peripheral and central telomerase activity are directly related, PBMC telomerase activity would be positively correlated with hippocampal volume, perhaps due to hippocampal telomerase-associated neurogenesis, neuroprotection or neurotrophic facilitation, and that this effect would be clearer in individuals with increased PBMC telomerase activity, as previously reported in un-medicated MDD. We did not have specific hypotheses regarding the relationship between leukocyte telomere length and hippocampal volume, due to conflicting reports in the published literature. We found, in 25 un-medicated MDD subjects, that PBMC telomerase activity was significantly positively correlated with hippocampal volume; this relationship was not observed in 18 healthy controls. Leukocyte telomere length was not significantly related to hippocampal volume in either group (19 unmedicated MDD subjects and 17 healthy controls). Although the nature of the relationship between peripheral telomerase activity and telomere length and the hippocampus is unclear, these preliminary data are consistent with the possibility that PBMC telomerase activity indexes, and may provide a novel window into, hippocampal neuroprotection and/or neurogenesis in MDD. (C) 2015 Elsevier Ireland Ltd. All rights reserved. C1 [Wolkowitz, Owen M.; Epel, Elissa S.; Reus, Victor I.; Burke, Heather; Rosser, Rebecca; Mahan, Laura; Mackin, Scott; Yang, Tony] Univ Calif San Francisco, Sch Med, Dept Psychiat, San Francisco, CA 94143 USA. [Mellon, Synthia H.] Univ Calif San Francisco, Sch Med, Dept OBGYN & Reprod Endocrinol, San Francisco, CA 94143 USA. [Lindqvist, Daniel] Lund Univ, Dept Clin Sci, Sect Psychiat, Lund, Sweden. [Blackburn, Elizabeth H.; Lin, Jue] Univ Calif San Francisco, Sch Med, Dept Biochem & Biophys, San Francisco, CA 94143 USA. [Weiner, Michael; Mueller, Susanne] Univ Calif San Francisco, Sch Med, Dept Radiol, San Francisco, CA 94143 USA. [Weiner, Michael; Mueller, Susanne] San Francisco Vet Adm Med Ctr, San Francisco, CA USA. RP Wolkowitz, OM (reprint author), Univ Calif San Francisco, Sch Med, Dept Psychiat, 401 Parnassus Ave, San Francisco, CA 94143 USA. EM Owen.Wolkowitz@ucsf.edu RI reus, victor/I-7923-2015 OI reus, victor/0000-0002-8193-5697 FU NIMH [1 R01 MH083784]; O'Shaughnessy Foundation; Tinberg Family; National Center for Research Resources; National Center for Advancing Translational Sciences, National Institutes of Health through UCSF-CTSI [UL1 RR024131] FX The research reported was supported by NIMH grant 1 R01 MH083784 (Co-PI's: O.M.W., E.S.E., S.H.M.), the UCSF Academic Senate and private donations from the O'Shaughnessy Foundation and the Tinberg Family. This project was also supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through UCSF-CTSI Grant number UL1 RR024131. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. NR 68 TC 5 Z9 6 U1 2 U2 11 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0925-4927 EI 1872-7506 J9 PSYCHIAT RES-NEUROIM JI Psychiatry Res. Neuroimaging PD APR 30 PY 2015 VL 232 IS 1 BP 58 EP 64 DI 10.1016/j.pscychresns.2015.01.007 PG 7 WC Clinical Neurology; Neuroimaging; Psychiatry SC Neurosciences & Neurology; Psychiatry GA CG9HJ UT WOS:000353625300005 PM 25773002 ER PT J AU Haghighi, F Galfalvy, H Chen, S Huang, YY Cooper, TB Burke, AK Oquendo, MA Mann, JJ Sublette, ME AF Haghighi, Fatemeh Galfalvy, Hanga Chen, Sean Huang, Yung-yu Cooper, Thomas B. Burke, Ainsley K. Oquendo, Maria A. Mann, J. John Sublette, M. Elizabeth TI DNA methylation perturbations in genes involved in polyunsaturated fatty acid biosynthesis associated with depression and suicide risk SO FRONTIERS IN NEUROLOGY LA English DT Article DE DNA methylation; epigenetics; suicide; major depressive disorder; polyunsaturated omega-3/omega-6; fatty acids; Fads1 fatty acid desaturase; elongation of very long-chain fatty acids protein 5 ID EICOSAPENTAENOIC ACID; DOCOSAHEXAENOIC ACID; PREFRONTAL CORTEX; DESATURASE; DISORDER; SUPPLEMENTATION; METAANALYSIS; METABOLISM; EFFICACY; TRIALS AB Polyunsaturated fatty acid (PUFA) status has been associated with neuropsychiatric disorders, including depression and risk of suicide. Long-chain PUFAs (LC-PUFAs) are obtained in the diet or produced by sequential desaturation and elongation of shorter-chain precursor fatty acids linoleic acid (LA, 18:2n-6) and a-linolenic acid (ALA, 18:3n-3). We compared DNA methylation patterns in genes involved in LC-PUFA biosynthesis in major depressive disorder (MDD) with (n =22) and without (n=39) history of suicide attempt, and age- and sex-matched healthy volunteers (n=59). Plasma levels of selected PUFAs along the LC-PUFA biosynthesis pathway were determined by transesterification and gas chromatography. CpG methylation levels for the main human LC-PUFA biosynthetic genes, fatty acid desaturases 1 (Fads 1) and 2 (Fads2), and elongation of very long-chain fatty acids protein 5 (ElovI5), were assayed by bisulfite pyrosequencing. Associations between PUFA levels and diagnosis or suicide attempt status did not survive correction for multiple testing. However, MDD diagnosis and suicide attempts were significantly associated with DNA methylation in ElovI5 gene regulatory regions. Also the relative roles of PUFA levels and DNA methylation with respect to diagnostic and suicide attempt status were determined by least absolute shrinkage and selection operator logistic regression analyses. We found that PUFA associations with suicide attempt status were explained by effects of ElovI5 DNA methylation within the regulatory regions. The observed link between plasma PUFA levels, DNA methylation, and suicide risk may have implications for modulation of disease-associated epigenetic marks by nutritional intervention. C1 [Haghighi, Fatemeh] James J Peters Vet Affairs Med Ctr, Dept Psychiat, New York, NY USA. [Haghighi, Fatemeh; Chen, Sean] Icahn Sch Med Mt Sinai, Fishberg Dept Neurosci, New York, NY 10029 USA. [Haghighi, Fatemeh; Chen, Sean] Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA. [Galfalvy, Hanga; Cooper, Thomas B.; Burke, Ainsley K.; Oquendo, Maria A.; Mann, J. John; Sublette, M. Elizabeth] Columbia Univ, Coll Phys & Surg, Dept Psychiat, New York, NY USA. [Galfalvy, Hanga] New York State Psychiat Inst & Hosp, Div Biostat, New York, NY 10032 USA. [Huang, Yung-yu; Cooper, Thomas B.; Burke, Ainsley K.; Oquendo, Maria A.; Mann, J. John; Sublette, M. Elizabeth] New York State Psychiat Inst & Hosp, Div Mol Imaging & Neuropathol, New York, NY 10032 USA. [Cooper, Thomas B.] Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA. [Mann, J. John] Columbia Univ, Coll Phys & Surg, Dept Radiol, New York, NY USA. RP Haghighi, F (reprint author), Icahn Sch Med Mt Sinai, James J Peters VA Med Ctr, 1425 Madison Ave,Floor 10,Room 10-70D, New York, NY 10029 USA. EM fatemeh.haghighi@mssm.edu RI Sublette, M/A-8391-2009 OI Sublette, M/0000-0001-7378-4262 NR 47 TC 6 Z9 6 U1 1 U2 9 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1664-2295 J9 FRONT NEUROL JI Front. Neurol. PD APR 28 PY 2015 VL 6 AR UNSP 92 DI 10.3389/fneur.2015.00092 PG 7 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA CU8GR UT WOS:000363780200001 PM 25972837 ER PT J AU Su, M Yang, CC Trikamji, B Mishra, S AF Su, Michael Yang, Chih-Chao Trikamji, Bhavesh Mishra, Shri TI HISTORY OF NEUROLOGY IN TAIWAN SO NEUROLOGY LA English DT Article AB Neurology, as an independent medical specialty, is a relatively young field, originally stemming from internal medicine and psychiatry. The roots of neurology in Taiwan are no different. Modern neurology in Taiwan was established in the 1950s. Prior to that, neurologic diseases were uncommon and mainly consisted of infectious diseases of CNS. The 1950s brought on the establishment of dedicated neurology clinics and primary neurology training at various sites in Taiwan.(1) The expansion of these sites continued to flourish over the next several decades. Neurology was further developed with the creation and induction of academic societies and conferences, as well as adoption of modern diagnostic techniques and therapeutics. This has firmly set neurology as a stand-alone specialty in Taiwan. C1 [Su, Michael] UCLA Med Ctr, Dept Neurol, Los Angeles, CA USA. [Yang, Chih-Chao] Natl Taiwan Univ Hosp, Dept Neurol, Taipei, Taiwan. [Trikamji, Bhavesh] Olive View UCLA Med Ctr, Dept Neurol, Sylmar, CA 91342 USA. [Trikamji, Bhavesh] VA Greater Los Angeles HCS, Dept Neurol, Los Angeles, CA USA. [Mishra, Shri] VA Greater Los Angeles Healthcare Syst, North Hills, CA 91343 USA. RP Mishra, S (reprint author), VA Greater Los Angeles Healthcare Syst, North Hills, CA 91343 USA. EM smishra@usc.edu NR 4 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0028-3878 EI 1526-632X J9 NEUROLOGY JI Neurology PD APR 28 PY 2015 VL 84 IS 17 BP 1803 EP 1804 DI 10.1212/WNL.0000000000001513 PG 2 WC Clinical Neurology SC Neurosciences & Neurology GA CH5GB UT WOS:000354062200019 PM 25917485 ER PT J AU Lin, YW Chen, CC Lin, LC Lee, SP AF Lin, Yu-Wei Chen, Chia-Chun Lin, Li-Ching Lee, Steve P. TI The Impact of Reduced-Volume, Intensity-Modulated Radiation Therapy on Disease Control in Nasopharyngeal Carcinoma SO PLOS ONE LA English DT Article ID NECK-CANCER; CLINICAL-OUTCOMES; TARGET VOLUMES; RADIOTHERAPY; HEAD; EXPERIENCE; PATTERNS; FAILURE; IRRADIATION; DELINEATION AB Objective To investigate the feasibility of using intensity-modulated radiotherapy (IMRT) with reduced, high-dose target volumes for nasopharyngeal carcinoma (NPC). Methods The first 57 patients (admitted from October 2005 to May 2008) were treated with large-target-volume IMRT (LV-IMRT). For the LV-IMRT group, the CTV at 70 Gy (CTV70) was delineated as the gross target volume (GTV) plus 7mm, with or without the first-echelon lymphnode region. The next 56 patients (admitted from June 2008 to November 2011) were treated with reduced-target-volume IMRT (RV-IMRT). For the RV-IMRT group, the CTV70 was delineated as the GTV alone. Results The 4-year local recurrence-free, regional recurrence-free, distant metastasis-free, progression-free, and overall survival rates were 77.2%, 80.1%, 83.2%, 61.2%, and 74.4% for the LV-IMRT group and 83.5%, 92.6%, 89.1%, 78.5, and 91.0% for the RV-IMRT group, respectively. Late toxicity scoring of xerostomia was lesser in the RV-IMRT group than the LV-IMRT group (P < 0.001). Conclusions The use of RV-IMRT for the treatment of NPC did not negatively affect survival rates but did reduce the late xerostomia events compared to LV-IMRT. C1 [Lin, Yu-Wei; Lin, Li-Ching] Chi Mei Med Ctr, Dept Radiat Oncol, Tainan, Taiwan. [Lin, Yu-Wei] Natl Sun Yat Sen Univ, Inst Biomed Sci, Kaohsiung 80424, Taiwan. [Lin, Yu-Wei] Kaohsiung Med Univ, Sch Med, Kaohsiung, Taiwan. [Chen, Chia-Chun] Chi Mei Med Ctr, Dept Radiat Oncol, Tainan, Taiwan. [Lin, Li-Ching] Taipei Med Univ, Sch Med, Taipei, Taiwan. [Lee, Steve P.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiat Oncol, Los Angeles, CA 90095 USA. [Lee, Steve P.] VA Greater Los Angeles Healthcare Syst, Dept Radiat Oncol, Los Angeles, CA USA. RP Lin, YW (reprint author), Chi Mei Med Ctr, Dept Radiat Oncol, Tainan, Taiwan. EM marklin1108@gmail.com; splee@mednet.ucla.edu NR 32 TC 2 Z9 2 U1 2 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 28 PY 2015 VL 10 IS 4 AR e0125283 DI 10.1371/journal.pone.0125283 PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CG9SE UT WOS:000353659400079 PM 25919285 ER PT J AU Neely, BA Ferrante, JA Chaves, JM Soper, JL Almeida, JS Arthur, JM Gulland, FMD Janech, MG AF Neely, Benjamin A. Ferrante, Jason A. Chaves, J. Mauro Soper, Jennifer L. Almeida, Jonas S. Arthur, John M. Gulland, Frances M. D. Janech, Michael G. TI Proteomic Analysis of Plasma from California Sea Lions (Zalophus californianus) Reveals Apolipoprotein E as a Candidate Biomarker of Chronic Domoic Acid Toxicosis SO PLOS ONE LA English DT Article ID TOXICITY; NMDA; GLYCOSYLATION; NEUROTOXICITY; PATHOLOGY; EPILEPSY; NEURONS; DISEASE; MODEL; RATS AB Domoic acid toxicosis (DAT) in California sea lions (Zalophus californianus) is caused by exposure to the marine biotoxin domoic acid and has been linked to massive stranding events and mortality. Diagnosis is based on clinical signs in addition to the presence of domoic acid in body fluids. Chronic DAT further is characterized by reoccurring seizures progressing to status epilepticus. Diagnosis of chronic DAT is often slow and problematic, and minimally invasive tests for DAT have been the focus of numerous recent biomarker studies. The goal of this study was to retrospectively profile plasma proteins in a population of sea lions with chronic DAT and those without DAT using two dimensional gel electrophoresis to discover whether individual, multiple, or combinations of protein and clinical data could be utilized to identify sea lions with DAT. Using a training set of 32 sea lion sera, 20 proteins and their isoforms were identified that were significantly different between the two groups (p<0.05). Interestingly, 11 apolipoprotein E (ApoE) charge forms were decreased in DAT samples, indicating that ApoE charge form distributions may be important in the progression of DAT. In order to develop a classifier of chronic DAT, an independent blinded test set of 20 sea lions, seven with chronic DAT, was used to validate models utilizing ApoE charge forms and eosinophil counts. The resulting support vector machine had high sensitivity (85.7% with 92.3% negative predictive value) and high specificity (92.3% with 85.7% positive predictive value). These results suggest that ApoE and eosinophil counts along with machine learning can perform as a robust and accurate tool to diagnose chronic DAT. Although this analysis is specifically focused on blood biomarkers and routine clinical data, the results demonstrate promise for future studies combining additional variables in multidimensional space to create robust classifiers. C1 [Neely, Benjamin A.; Ferrante, Jason A.; Chaves, J. Mauro; Arthur, John M.; Janech, Michael G.] Med Univ S Carolina, Dept Med, Div Nephrol, Charleston, SC 29425 USA. [Ferrante, Jason A.; Janech, Michael G.] Coll Charleston, Grice Marine Lab, Charleston, SC 29401 USA. [Soper, Jennifer L.; Gulland, Frances M. D.] Marine Mammal Ctr, Sausalito, CA USA. [Almeida, Jonas S.] SUNY Stony Brook, Dept Biomed Informat, Long Isl City, NY USA. [Arthur, John M.; Janech, Michael G.] Ralph H Johnson VA Med Ctr, Res Serv, Charleston, SC USA. RP Janech, MG (reprint author), Med Univ S Carolina, Dept Med, Div Nephrol, Charleston, SC 29425 USA. EM janechmg@musc.edu OI Neely, Benjamin/0000-0001-6120-7695 FU Office of Naval Research [N00014-08-1-0341] FX Funding: Funding for this work, and for BAN JAF JMC JLS JSA JMA FMDG MGJ, was provided by the Office of Naval Research (N00014-08-1-0341). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 39 TC 3 Z9 3 U1 2 U2 11 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 28 PY 2015 VL 10 IS 4 AR e0123295 DI 10.1371/journal.pone.0123295 PG 18 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CG9SE UT WOS:000353659400026 ER PT J AU McFarland, LV Malfertheiner, P Huang, Y Wang, L AF McFarland, Lynne V. Malfertheiner, Peter Huang, Ying Wang, Lin TI Meta-analysis of single strain probiotics for the eradication of Helicobacter pylori and prevention of adverse events SO WORLD JOURNAL OF META-ANALYSIS LA English DT Review DE Probiotics; Safety; Saccharomyces boulardii; Helicobacter pylori; Meta-analysis; Adverse reactions; Diarrhea; Lactobacillus rhamnosus; Randomized clinical trials ID PLACEBO-CONTROLLED TRIAL; ANTIBIOTIC-ASSOCIATED DIARRHEA; LACTOBACILLUS GG SUPPLEMENTATION; RANDOMIZED CONTROLLED-TRIALS; SACCHAROMYCES-BOULARDII; DOUBLE-BLIND; INTESTINAL MICROBIOTA; FERMENTED MILK; TRIPLE THERAPY; PARALLEL-GROUP AB AIM: To assess the efficacy and safety of single strain probiotics for the: (1) eradication of Helicobacter pylori (H. pylori); (2) prevention of adverse events; and (3) prevention of antibiotic-associated diarrhea associated with eradication therapy. METHODS: We searched PubMed (1960-2014), EMBASE (1974-2014), Cochrane Database of Systematic Reviews (1990-2014), and ISI Web of Science (2000-2014). Additionally, we conducted a grey literature search including contact with National Institutes of Health Clinical Trials Registry, abstracts from annual infectious disease and gastroenterology meetings, experts in the field and correspondence with authors. Randomized controlled trials of H. pylori positive adults or children treated with eradication therapy and assessing the adjunctive therapy with a single strain of probiotics were included. The primary outcomes were the rates of eradication of H. pylori and frequency of patients with adverse events or antibiotic-associated diarrhea. Outcomes were pooled using fixed or random-effects models to calculate the relative risk and corresponding 95%CI and weighted on study size. To explore possible explanations for heterogeneity, a priori subgroup analyses were conducted on daily probiotic dose, study population, and quality of the study. The overall quality of the evidence for each probiotic strain was assessed using the GRADE criteria. RESULTS: A total of 25 randomized controlled trials (28 treatment arms, with a total of 3769 participants) assessed one of six single probiotic strains as adjunctive treatments to standard eradication therapy. Only one probiotic strain significantly improved H. pylori eradication rates: Saccharomyces boulardii (S. boulardii) CNCM I-745 [pooled relative risks (pRR) = 1.11, 95% CI: 1.07-1.16]. Only one probiotic strain (S. boulardii CNCM I-745) significantly prevented any adverse events (pRR = 0.42, 95% CI: 0.28-0.62). Both S. boulardii CNCM I-745 and Lactobacillus rhamnosus GG significantly reduced antibiotic-associated diarrhea (pRR = 0.47, 95%CI: 0.37-0.60 and pRR = 0.29, 95%CI: 0.17-0.48, respectively) associated with H. pylori eradication therapy. Meta-regression of sub-groups did not detect significant differences by dose, adult vs pediatric, symptom status, or study quality, but did find significant differences by the strain of probiotic. Potential mild publication bias was found for antibiotic-associated diarrhea, but not for eradication or adverse event outcomes. Analysis of the study quality illuminated areas for improvement in future studies (use of placebos, study size calculations, attrition reasons and discussion of limitations and generalizability). CONCLUSION: The pooled evidence suggests that the adjunctive use of a few probiotic strains may improve H. pylori eradication rates and prevent the development of adverse events and antibiotic-associated diarrhea in those treated with standard eradication therapies. The type of probiotic strain was the most important factor in predicting efficacy. C1 [McFarland, Lynne V.] Univ Washington, Dept Med Chem, Seattle, WA 98195 USA. [McFarland, Lynne V.] VA Puget Sound Hlth Care Syst, Dept Vet Affairs, Hlth Serv Res & Dev, Seattle, WA 98101 USA. [Malfertheiner, Peter] Univ Klinikum Magdeburg AOR, D-39120 Magdeburg, Germany. [Huang, Ying; Wang, Lin] Fudan Univ, Childrens Hosp, Shanghai 201102, Peoples R China. RP McFarland, LV (reprint author), VA Puget Sound Hlth Care Syst, Dept Vet Affairs, Hlth Serv Res & Dev, Metropolitan Pk West,1100 Olive Way 1400, Seattle, WA 98101 USA. EM lvmcfarl@u.washington.edu NR 96 TC 3 Z9 4 U1 2 U2 6 PU BAISHIDENG PUBLISHING GROUP INC PI PLEASANTON PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA SN 2308-3840 J9 WORLD J META-ANAL JI World J. Meta-Anal. PD APR 26 PY 2015 VL 3 IS 2 BP 97 EP 117 PG 21 WC Mathematical & Computational Biology SC Mathematical & Computational Biology GA CR0GB UT WOS:000360995400004 ER PT J AU Krumholz, A Wiebe, S Gronseth, GS Gloss, DS Sanchez, AM Kabir, AA Liferidge, AT Martello, JP Kanner, AM Shinnar, S Hopp, JL French, JA AF Krumholz, Allan Wiebe, Samuel Gronseth, Gary S. Gloss, David S. Sanchez, Ana M. Kabir, Arif A. Liferidge, Aisha T. Martello, Justin P. Kanner, Andres M. Shinnar, Shlomo Hopp, Jennifer L. French, Jacqueline A. CA Amer Acad Neurology TI Evidence-based guideline: Management of an unprovoked first seizure in adults Report of the Guideline Development Subcommittee of the American Academy of Neurology and the American Epilepsy Society SO NEUROLOGY LA English DT Article ID TONIC-CLONIC SEIZURE; QUALITY STANDARDS SUBCOMMITTEE; RANDOMIZED CLINICAL-TRIAL; NEW-ONSET EPILEPSY; ANTIEPILEPTIC DRUGS; PRACTICE PARAMETER; SINGLE SEIZURES; FOLLOW-UP; RECURRENCE; RISK AB Objective:To provide evidence-based recommendations for treatment of adults with an unprovoked first seizure.Methods:We defined relevant questions and systematically reviewed published studies according to the American Academy of Neurology's classification of evidence criteria; we based recommendations on evidence level.Results and recommendations:Adults with an unprovoked first seizure should be informed that their seizure recurrence risk is greatest early within the first 2 years (21%-45%) (Level A), and clinical variables associated with increased risk may include a prior brain insult (Level A), an EEG with epileptiform abnormalities (Level A), a significant brain-imaging abnormality (Level B), and a nocturnal seizure (Level B). Immediate antiepileptic drug (AED) therapy, as compared with delay of treatment pending a second seizure, is likely to reduce recurrence risk within the first 2 years (Level B) but may not improve quality of life (Level C). Over a longer term (>3 years), immediate AED treatment is unlikely to improve prognosis as measured by sustained seizure remission (Level B). Patients should be advised that risk of AED adverse events (AEs) may range from 7% to 31% (Level B) and that these AEs are likely predominantly mild and reversible. Clinicians' recommendations whether to initiate immediate AED treatment after a first seizure should be based on individualized assessments that weigh the risk of recurrence against the AEs of AED therapy, consider educated patient preferences, and advise that immediate treatment will not improve the long-term prognosis for seizure remission but will reduce seizure risk over the subsequent 2 years. C1 [Krumholz, Allan] Univ Maryland, Sch Med, Dept Neurol, Maryland Epilepsy Ctr, Baltimore, MD 21201 USA. [Sanchez, Ana M.; Kabir, Arif A.; Martello, Justin P.; Hopp, Jennifer L.] Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA. [Krumholz, Allan] US Dept Vet Affairs, Maryland Healthcare Syst, Epilepsy Ctr Excellence, Baltimore, MD USA. [Wiebe, Samuel] Univ Calgary, Fac Med, Dept Clin Neurosci, Calgary, AB T2N 1N4, Canada. [Gronseth, Gary S.] Univ Kansas, Dept Neurol, Sch Med, Kansas City, KS USA. [Gloss, David S.] Geisinger Hlth Syst, Dept Neurol, Danville, PA USA. [Liferidge, Aisha T.] George Washington Univ, Sch Med, Dept Emergency Med, Washington, DC USA. [Kanner, Andres M.] Univ Miami, Miller Sch Med, Int Ctr Epilepsy, Dept Neurol, Coral Gables, FL 33124 USA. [Shinnar, Shlomo] Yeshiva Univ, Dept Neurol, Albert Einstein Coll Med, Bronx, NY USA. [Shinnar, Shlomo] Yeshiva Univ, Dept Pediat, Albert Einstein Coll Med, Bronx, NY USA. [Shinnar, Shlomo] Yeshiva Univ, Dept Epidemiol, Albert Einstein Coll Med, Bronx, NY USA. [Shinnar, Shlomo] Yeshiva Univ, Dept Populat Hlth, Albert Einstein Coll Med, Bronx, NY USA. [French, Jacqueline A.] NYU, Comprehens Epilepsy Ctr, New York, NY USA. RI French, Jacqueline/G-6795-2013 OI French, Jacqueline/0000-0003-2242-8027 FU American Academy of Neurology FX This guideline was developed with financial support from the American Academy of Neurology. NR 38 TC 30 Z9 30 U1 0 U2 11 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0028-3878 EI 1526-632X J9 NEUROLOGY JI Neurology PD APR 21 PY 2015 VL 84 IS 16 BP 1705 EP 1713 DI 10.1212/WNL.0000000000001487 PG 9 WC Clinical Neurology SC Neurosciences & Neurology GA CG4GJ UT WOS:000353243200018 PM 25901057 ER PT J AU Bai, XY Shang, SB Henao-Tamayo, M Basaraba, RJ Ovrutsky, AR Matsuda, JL Takeda, K Chan, MM Dakhama, A Kinney, WH Trostel, J Bai, A Honda, JR Achcar, R Hartney, J Joosten, LAB Kim, SH Orme, I Dinarello, CA Ordway, DJ Chan, ED AF Bai, Xiyuan Shang, Shaobin Henao-Tamayo, Marcela Basaraba, Randall J. Ovrutsky, Alida R. Matsuda, Jennifer L. Takeda, Katsuyuki Chan, Mallory M. Dakhama, Azzeddine Kinney, William H. Trostel, Jessica Bai, An Honda, Jennifer R. Achcar, Rosane Hartney, John Joosten, Leo A. B. Kim, Soo-Hyun Orme, Ian Dinarello, Charles A. Ordway, Diane J. Chan, Edward D. TI Human IL-32 expression protects mice against a hypervirulent strain of Mycobacterium tuberculosis SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE cytokine; transgenic mouse; tuberculosis; host immunity; interleukin-32 ID PROINFLAMMATORY CYTOKINE; RHEUMATOID-ARTHRITIS; INTERLEUKIN-32; INFECTION; CELLS; INFLAMMATION; IL-32-GAMMA; ISOFORM AB Silencing of interleukin-32 (IL-32) in a differentiated human promonocytic cell line impairs killing of Mycobacterium tuberculosis (MTB) but the role of IL-32 in vivo against MTB remains unknown. To study the effects of IL-32 in vivo, a transgenic mouse was generated in which the human IL-32 gamma gene is expressed using the surfactant protein C promoter (SPC-IL-32 gamma Tg). Wild-type and SPC-IL-32 gamma Tg mice were infected with a low-dose aerosol of a hypervirulent strain of MTB (W-Beijing HN878). At 30 and 60 d after infection, the transgenic mice had 66% and 85% fewer MTB in the lungs and 49% and 68% fewer MTB in the spleens, respectively; the transgenic mice also exhibited greater survival. Increased numbers of host-protective innate and adaptive immune cells were present in SPC-IL-32 gamma Tg mice, including tumor necrosis factor-alpha (TNF alpha) positive lung macrophages and dendritic cells, and IFN-gamma (IFN gamma) and TNF alpha positive CD4(+) and CD8(+) T cells in the lungs and mediastinal lymph nodes. Alveolar macrophages from transgenic mice infected with MTB ex vivo had reduced bacterial burden and increased colocalization of green fluorescent protein-labeled MTB with lysosomes. Furthermore, mouse macrophages made to express IL-32. but not the splice variant IL-32 beta were better able to limit MTB growth than macrophages capable of producing both. The lungs of patients with tuberculosis showed increased IL-32 expression, particularly in macrophages of granulomas and airway epithelial cells but also B cells and T cells. We conclude that IL-32 gamma enhances host immunity to MTB. C1 [Bai, Xiyuan; Ovrutsky, Alida R.; Chan, Edward D.] Denver Vet Affairs Med Ctr, Denver, CO 80206 USA. [Shang, Shaobin; Henao-Tamayo, Marcela; Basaraba, Randall J.; Orme, Ian; Ordway, Diane J.] Colorado State Univ, Dept Microbiol Immunol & Pathol, Mycobacteria Res Labs, Ft Collins, CO 80523 USA. [Bai, Xiyuan; Ovrutsky, Alida R.; Matsuda, Jennifer L.; Chan, Mallory M.; Kinney, William H.; Trostel, Jessica; Bai, An; Honda, Jennifer R.; Hartney, John; Chan, Edward D.] Natl Jewish Hlth, Dept Med, Denver, CO 80206 USA. [Takeda, Katsuyuki; Dakhama, Azzeddine] Natl Jewish Hlth, Dept Pediat, Denver, CO 80206 USA. [Achcar, Rosane] Natl Jewish Hlth, Dept Pathol, Denver, CO 80206 USA. [Joosten, Leo A. B.; Dinarello, Charles A.] Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, Nijmegen, Netherlands. [Kim, Soo-Hyun] Konkuk Univ, Dept Biomed Sci & Technol, Seoul, South Korea. [Ovrutsky, Alida R.; Honda, Jennifer R.; Chan, Edward D.] Univ Colorado, Div Pulm Sci & Crit Care Med, Aurora, CO 80045 USA. [Dinarello, Charles A.] Univ Colorado, Div Infect Dis, Aurora, CO 80045 USA. RP Bai, XY (reprint author), Denver Vet Affairs Med Ctr, Denver, CO 80206 USA. EM BaiX@NJHealth.org; cdinare333@aol.com; ChanE@NJHealth.org RI Joosten, Leo/H-3138-2015; Shang, Shaobin/K-5669-2015; Henao-Tamayo, Marcela/D-8189-2017 OI Shang, Shaobin/0000-0003-4407-1911; Henao-Tamayo, Marcela/0000-0002-4249-9650 FU Department of Veterans Affairs Veterans Health Administration, Office of Research and Development [1 I01 BX001028-01A2]; National Institutes of Health (NIH) [AI15614]; National Research Foundation of Korea; NIH [R21 AI081959, 1DP2OD006450]; American Recovery and Reinvestment Act funds FX We thank Dr. Stephan W. Glasser (University of Cincinnati) for providing the SPC expression vector pUC18SPC3.7, Drs. Carlyne Cool and Steve Groshong of National Jewish Health for advice on the use of the Aperio technology, and Drs. Su Young and Jida Choi for measuring the IL-32 levels in the lungs of the SPC-IL-32 gamma Tg mice. This study was funded by grants from the Department of Veterans Affairs Veterans Health Administration, Office of Research and Development 1 I01 BX001028-01A2 (to E.D.C.); National Institutes of Health (NIH) AI15614 (to C.A.D.); National Research Foundation of Korea (S.-H.K.); and NIH R21 AI081959, NIH Innovation Award 1DP2OD006450, and American Recovery and Reinvestment Act funds (to D.J.O.). NR 29 TC 5 Z9 6 U1 2 U2 10 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR 21 PY 2015 VL 112 IS 16 BP 5111 EP 5116 DI 10.1073/pnas.1424302112 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CG4FJ UT WOS:000353239100072 PM 25820174 ER PT J AU Becker, A Kannan, TR Taylor, AB Pakhomova, ON Zhang, Y Somarajan, SR Galaleldeen, A Holloway, SP Baseman, JB Hart, PJ AF Becker, Argentina Kannan, T. R. Taylor, Alexander B. Pakhomova, Olga N. Zhang, Yanfeng Somarajan, Sudha R. Galaleldeen, Ahmad Holloway, Stephen P. Baseman, Joel B. Hart, P. John TI Structure of CARDS toxin, a unique ADP-ribosylating and vacuolating cytotoxin from Mycoplasma pneumoniae SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE mycoplasma cytotoxin; single-crystal X-ray diffraction; ADP-ribosyltransferase; vacuolation; reactive airway disease ID DISTRESS-SYNDROME TOXIN; SURFACTANT PROTEIN-A; CHOLERA-TOXIN; PULMONARY SURFACTANT; CRYSTAL-STRUCTURE; BINDING SITE; INFLAMMATION; PATHOGEN; ASTHMA; LIPIDS AB Mycoplasma pneumoniae (Mp) infections cause tracheobronchitis and "walking" pneumonia, and are linked to asthma and other reactive airway diseases. As part of the infectious process, the bacterium expresses a 591-aa virulence factor with both mono-ADP ribosyltransferase (mART) and vacuolating activities known as Community-Acquired Respiratory Distress Syndrome Toxin (CARDS TX). CARDS TX binds to human surfactant protein A and annexin A2 on airway epithelial cells and is internalized, leading to a range of pathogenetic events. Here we present the structure of CARDS TX, a triangular molecule in which N-terminal mART and C-terminal tandem beta-trefoil domains associate to form an overall architecture distinct from other well-recognized ADP-ribosylating bacterial toxins. We demonstrate that CARDS TX binds phosphatidylcholine and sphingomyelin specifically over other membrane lipids, and that cell surface binding and internalization activities are housed within the C-terminal beta-trefoil domain. The results enhance our understanding of Mp pathogenicity and suggest a novel avenue for the development of therapies to treat Mp-associated asthma and other acute and chronic airway diseases. C1 [Becker, Argentina; Taylor, Alexander B.; Pakhomova, Olga N.; Zhang, Yanfeng; Galaleldeen, Ahmad; Holloway, Stephen P.; Hart, P. John] Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem, San Antonio, TX 78229 USA. [Kannan, T. R.; Somarajan, Sudha R.; Baseman, Joel B.] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, Ctr Airway Inflammat Res, San Antonio, TX 78229 USA. [Taylor, Alexander B.; Hart, P. John] Univ Texas Hlth Sci Ctr San Antonio, XRay Crystallog Core Lab, San Antonio, TX 78229 USA. [Pakhomova, Olga N.] Old Dominion Univ, Frank Reidy Ctr Bioelect, Norfolk, VA 23508 USA. [Galaleldeen, Ahmad] St Marys Univ, Dept Biol Sci, San Antonio, TX 78228 USA. [Hart, P. John] US Dept Vet Affairs, South Texas Vet Hlth Care Syst, San Antonio, TX 78229 USA. RP Baseman, JB (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, Ctr Airway Inflammat Res, San Antonio, TX 78229 USA. EM baseman@uthscsa.edu; pjh@biochem.uthscsa.edu OI Pakhomova, Olga/0000-0003-4950-4130 FU National Institutes of Health [U19 AI070412, P41 GM103403]; Kleberg Foundation; R.A. Welch Foundation [AQ-1399]; US Department of Energy [DE-AC02-06CH11357]; Office of the Vice President for Research; San Antonio Cancer Institute Grant [P30 CA054174] FX We thank Jonathan Schuermann for technical support. J.B.B., P.J.H., and coauthors are supported by National Institutes of Health Grant U19 AI070412. J.B.B. is also supported by the Kleberg Foundation. P.J.H. is also supported by R.A. Welch Foundation Grant AQ-1399. Support for Northeastern Collaborative Access Team beamline 24-ID-E is provided by National Institutes of Health Grant P41 GM103403 and US Department of Energy Grant DE-AC02-06CH11357. The University of Texas Health Science Center at San Antonio's X-Ray Crystallography Core Laboratory is supported in part by the Office of the Vice President for Research and by San Antonio Cancer Institute Grant P30 CA054174. NR 49 TC 8 Z9 11 U1 3 U2 11 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR 21 PY 2015 VL 112 IS 16 BP 5165 EP 5170 DI 10.1073/pnas.1420308112 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CG4FJ UT WOS:000353239100081 PM 25848012 ER PT J AU Belendiuk, KA Baldini, LL Bonn-Miller, MO AF Belendiuk, Katherine A. Baldini, Lisa L. Bonn-Miller, Marcel O. TI Narrative review of the safety and efficacy of marijuana for the treatment of commonly stateapproved medical and psychiatric disorders SO ADDICTION SCIENCE & CLINICAL PRACTICE LA English DT Review DE Cannabis; Medical marijuana; Marijuana; Medicine; Treatment; Alzheimer's disease; ALS; Cachexia; Cancer; Crohn's disease; Epilepsy; Seizures; Glaucoma; Hepatitis C virus; HCV; HIV; AIDS; Multiple sclerosis; MS; Pain; Nausea; Vomiting; Post-traumatic stress disorder; PTSD AB The present investigation aimed to provide an objective narrative review of the existing literature pertaining to the benefits and harms of marijuana use for the treatment of the most common medical and psychological conditions for which it has been allowed at the state level. Common medical conditions for which marijuana is allowed (i. e., those conditions shared by at least 80 percent of medical marijuana states) were identified as: Alzheimer's disease, amyotrophic lateral sclerosis, cachexia/wasting syndrome, cancer, Crohn's disease, epilepsy and seizures, glaucoma, hepatitis C virus, human immunodeficiency virus/acquired immunodeficiency syndrome, multiple sclerosis and muscle spasticity, severe and chronic pain, and severe nausea. Post-traumatic stress disorder was also included in the review, as it is the sole psychological disorder for which medical marijuana has been allowed. Studies for this narrative review were included based on a literature search in PsycINFO, MEDLINE, and Google Scholar. Findings indicate that, for the majority of these conditions, there is insufficient evidence to support the recommendation of medical marijuana at this time. A significant amount of rigorous resna for these conditions. It is important for such work to not only examearch is needed to definitively ascertain the potential implications of marijuaine the effects of smoked marijuana preparations, but also to compare its safety, tolerability, and efficacy in relation to existing pharmacological treatments. C1 [Belendiuk, Katherine A.] Univ Calif, Inst Human Dev, 1121 Tolman Hall # 1690, Berkeley, CA 94720 USA. [Baldini, Lisa L.] Palo Alto Univ, 1791 Arastradero Rd, Palo Alto, CA 94304 USA. [Bonn-Miller, Marcel O.] Philadelphia VA Med Ctr, Ctr Excellence Substance Abuse Treatment & Educ, 3900 Woodland Ave, Philadelphia, PA 19104 USA. [Bonn-Miller, Marcel O.] Ctr Innovat Implementat, 795 Willow Rd 152-MPD, Menlo Pk, CA 94025 USA. [Bonn-Miller, Marcel O.] Natl Ctr PTSD, VA Palo Alto Hlth Care Syst, 795 Willow Rd 152-MPD, Menlo Pk, CA 94025 USA. Univ Penn, Perelman Sch Med, Dept Psychiat, 3440 Market St, Philadelphia, PA 19104 USA. RP Bonn-Miller, MO (reprint author), Philadelphia VA Med Ctr, Ctr Excellence Substance Abuse Treatment & Educ, 3900 Woodland Ave, Philadelphia, PA 19104 USA. EM Marcel.Bonn-Miller@va.gov FU National Institute of Mental Health [R01 MH40564]; VA Center of Excellence for Substance Abuse Treatment and Education; VA Substance Use Disorder Quality Enhancement Research Initiative [SUDQ-LIP1410] FX Dr. Belendiuk's salary was supported by National Institute of Mental Health R01 MH40564. Dr. Bonn-Miller's salary was supported by the VA Center of Excellence for Substance Abuse Treatment and Education. Literature review and synthesis was supported by a grant from the VA Substance Use Disorder Quality Enhancement Research Initiative (SUDQ-LIP1410). The above funding agencies played no role in the writing of the manuscript or decision to submit the manuscript for publication. The expressed views do not necessarily represent those of the Department of Veterans Affairs. NR 136 TC 8 Z9 8 U1 0 U2 11 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1940-0640 J9 ADDICT SCI CLIN PRAC JI Addict. Sci. Clin. Pract. PD APR 21 PY 2015 VL 10 AR 10 DI 10.1186/s13722-015-0032-7 PG 10 WC Substance Abuse SC Substance Abuse GA V49JJ UT WOS:000210083000001 PM 25896576 ER PT J AU Bill, A Gutierrez, A Kulkarni, S Kemp, C Bonenfant, D Voshol, H Duvvuri, U Gaither, LA AF Bill, Anke Gutierrez, Abraham Kulkarni, Sucheta Kemp, Carolyn Bonenfant, Debora Voshol, Hans Duvvuri, Umamaheswar Gaither, L. Alex TI ANO1/TMEM16A interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer SO ONCOTARGET LA English DT Article DE epidermal growth factor receptor (EGFR); EGFR-targeted therapy; biomarker; calcium-activated chloride channel; protein-protein interaction ID GROWTH-FACTOR RECEPTOR; SQUAMOUS-CELL CARCINOMA; ACTIVATED CHLORIDE CHANNEL; INTERSTITIAL-CELLS; TYROSINE KINASES; PHASE-II; TMEM16A; EXPRESSION; PROTEIN; ANO1 AB The epidermal growth factor receptor (EGFR) contributes to the pathogenesis of head&neck squamous cell carcinoma (HNSCC). However, only a subset of HNSCC patients benefit from anti-EGFR targeted therapy. By performing an unbiased proteomics screen, we found that the calcium-activated chloride channel ANO1 interacts with EGFR and facilitates EGFR-signaling in HNSCC. Using structural mutants of EGFR and ANO1 we identified the trans/juxtamembrane domain of EGFR to be critical for the interaction with ANO1. Our results show that ANO1 and EGFR form a functional complex that jointly regulates HNSCC cell proliferation. Expression of ANO1 affected EGFR stability, while EGFR-signaling elevated ANO1 protein levels, establishing a functional and regulatory link between ANO1 and EGFR. Co-inhibition of EGFR and ANO1 had an additive effect on HNSCC cell proliferation, suggesting that co-targeting of ANO1 and EGFR could enhance the clinical potential of EGFR-targeted therapy in HNSCC and might circumvent the development of resistance to single agent therapy. HNSCC cell lines with amplification and high expression of ANO1 showed enhanced sensitivity to Gefitinib, suggesting ANO1 overexpression as a predictive marker for the response to EGFR-targeting agents in HNSCC therapy. Taken together, our results introduce ANO1 as a promising target and/or biomarker for EGFR-directed therapy in HNSCC. C1 [Bill, Anke; Gutierrez, Abraham; Gaither, L. Alex] Novartis Inst Biomed Res, Cambridge, MA 02139 USA. [Kulkarni, Sucheta; Kemp, Carolyn; Duvvuri, Umamaheswar] Univ Pittsburgh, Dept Otolaryngol, Med Ctr, Pittsburgh, PA 15213 USA. [Bonenfant, Debora; Voshol, Hans] Novartis Inst Biomed Res, CH-4002 Basel, Switzerland. [Duvvuri, Umamaheswar] VA Pittsburgh HealthCare Syst, Pittsburgh, PA 15213 USA. RP Gaither, LA (reprint author), Novartis Inst Biomed Res, Cambridge, MA 02139 USA. EM duvvuriu@upmc.edu; alex.gaither@novartis.com FU Department of Veterans Affairs BLSR&D PNC Foundation FX This work was supported in part by funds from the Department of Veterans Affairs BLSR&D PNC Foundation (U.D.). NR 62 TC 10 Z9 10 U1 0 U2 6 PU IMPACT JOURNALS LLC PI ALBANY PA 6211 TIPTON HOUSE, STE 6, ALBANY, NY 12203 USA SN 1949-2553 J9 ONCOTARGET JI Oncotarget PD APR 20 PY 2015 VL 6 IS 11 BP 9173 EP 9188 PG 16 WC Oncology; Cell Biology SC Oncology; Cell Biology GA CN9NB UT WOS:000358774600053 PM 25823819 ER PT J AU Mitsui, Y Hirata, H Arichi, N Hiraki, M Yasumoto, H Chang, I Fukuhara, S Yamamura, S Shahryari, V Deng, GR Saini, S Majid, S Dahiya, R Tanaka, Y Shiina, H AF Mitsui, Yozo Hirata, Hiroshi Arichi, Naoko Hiraki, Miho Yasumoto, Hiroaki Chang, Inik Fukuhara, Shinichiro Yamamura, Soichiro Shahryari, Varahram Deng, Guoren Saini, Sharanjot Majid, Shahana Dahiya, Rajvir Tanaka, Yuichiro Shiina, Hiroaki TI Inactivation of bone morphogenetic protein 2 may predict clinical outcome and poor overall survival for renal cell carcinoma through epigenetic pathways SO ONCOTARGET LA English DT Article DE bone morphogenetic protein 2; renal cell carcinoma; DNA methylation; molecular marker ID CANCER CELLS; EXTERNAL VALIDATION; EXPRESSION; DIFFERENTIATION; INHIBITOR; GROWTH; METHYLATION; POPULATION; RECEPTORS; P27(KIP1) AB We investigated whether impaired regulation of bone morphogenetic protein-2 (BMP-2) via epigenetic pathways is associated with renal cell carcinoma (RCC) pathogenesis. Expression and CpG methylation of the BMP-2 gene were analyzed using RCC cell lines, and 96 matched RCC and normal renal tissues. We also performed functional analysis using BMP-2 restored RCC cells. A significant association of BMP-2 mRNA expression was also found with advanced tumor stage and lymph node involvement, while lower BMP-2 mRNA expression was significantly associated with poor overall survival after radical nephrectomy. In RCC cells, BMP-2 restoration significantly inhibited cell proliferation, migration, invasion, and colony formation. In addition, BMP-2 overexpression induced p21(WAF1/CIP1) and p27(KIP1) expression, and cellular apoptosis in RCC cells. BMP-2 mRNA expression was significantly enhanced in RCC cells by 5-aza-2'-deoxycitidine treatment. The prevalence of BMP-2 promoter methylation was significantly greater and BMP-2 mRNA expression was significantly lower in RCC samples as compared to normal kidney samples. Furthermore, a significant correlation was found between BMP-2 promoter methylation and mRNA transcription in tumors. Aberrant BMP-2 methylation and the resultant loss of BMP-2 expression may be a useful molecular marker for designing improved diagnostic and therapeutic strategies for RCC. C1 [Mitsui, Yozo; Arichi, Naoko; Hiraki, Miho; Yasumoto, Hiroaki; Shiina, Hiroaki] Shimane Univ, Fac Med, Dept Urol, Enya, Izumo, Japan. [Mitsui, Yozo; Hirata, Hiroshi; Yamamura, Soichiro; Shahryari, Varahram; Deng, Guoren; Saini, Sharanjot; Majid, Shahana; Dahiya, Rajvir; Tanaka, Yuichiro] San Francisco VA Med Ctr, Dept Urol, San Francisco, CA USA. [Mitsui, Yozo; Hirata, Hiroshi; Yamamura, Soichiro; Shahryari, Varahram; Deng, Guoren; Saini, Sharanjot; Majid, Shahana; Dahiya, Rajvir; Tanaka, Yuichiro] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Chang, Inik] Yonsei Univ, Coll Densitry, Dept Oral Biol, Seoul 120749, South Korea. [Fukuhara, Shinichiro] Osaka Univ, Grad Sch Med, Dept Urol, Suita, Osaka, Japan. RP Mitsui, Y (reprint author), Shimane Univ, Fac Med, Dept Urol, Enya, Izumo, Japan. EM mitsui@med.shimane-u.ac.jp FU National Center for Research Resources of the NIH [RO1CA130860]; VA Merit Review and VA Program Project FX Address all correspondence and requests for Yozo Mitsui, MD, PhD, Departments of Urology, Shimane University Faculty of Medicine, 89-1 Enya-cho, 693-8501 Izumo, Japan. E-mail: mitsui@med.shimane-u.ac.jp. We thank Dr. Roger Erickson for his support and assistance with the preparation of the manuscript. This research study was supported by the National Center for Research Resources of the NIH through Grant Number RO1CA130860 and VA Merit Review and VA Program Project. NR 42 TC 4 Z9 4 U1 0 U2 2 PU IMPACT JOURNALS LLC PI ALBANY PA 6211 TIPTON HOUSE, STE 6, ALBANY, NY 12203 USA SN 1949-2553 J9 ONCOTARGET JI Oncotarget PD APR 20 PY 2015 VL 6 IS 11 BP 9577 EP 9591 PG 15 WC Oncology; Cell Biology SC Oncology; Cell Biology GA CN9NB UT WOS:000358774600083 PM 25797254 ER PT J AU Ogdie, A Pang, WG Forde, KA Samir, BD Mulugeta, L Chang, KM Kaplan, DE Amorosa, VK Kostman, JR Reddy, RK Schumacher, RH Lo Re, V AF Ogdie, Alexis Pang, Wyki Gina Forde, Kimberly A. Samir, Bhangle D. Mulugeta, Lakeisha Chang, Kyong-Mi Kaplan, David E. Amorosa, Valerianna K. Kostman, Jay R. Reddy, Rajender K. Schumacher, Ralph H. Lo Re, Vincent, III TI Prevalence and risk factors for patient-reported joint pain among patients with HIV/Hepatitis C coinfection, Hepatitis C monoinfection, and HIV monoinfection SO BMC MUSCULOSKELETAL DISORDERS LA English DT Article DE Hepatitis c; HIV; Arthralgia; Epidemiology ID HEALTH-ASSESSMENT QUESTIONNAIRE; RHEUMATIC-DISEASES; VIRUS-INFECTION; ROUTINE ASSESSMENT; INDEX; MDHAQ; CARE; MANIFESTATIONS; FIBROMYALGIA; SYMPTOMS AB Background: To determine the prevalence of patient-reported joint pain among patients with human immunodeficiency virus (HIV)/chronic hepatitis C virus (HCV) coinfection, chronic HCV monoinfection, and HIV monoinfection followed in hepatology and infectious disease outpatient practices. Methods: Standardized interviews were performed among 79 HIV/HCV-coinfected, 93 HCV-monoinfected, and 30 HIV-monoinfected patients in a cross-sectional study within hepatology and infectious disease clinics at three centers. The Multi-Dimensional Health Assessment Questionnaire was used to ascertain joint pain and associated symptoms. Information on potential risk factors for joint pain was obtained during the interview and by chart review. Logistic regression was used to determine adjusted odds ratios (aORs) with 95% confidence intervals (CIs) of joint pain associated with risk factors of interest among chronic HCV-infected and HIV-infected patients. Results: Joint pain was more commonly reported in HCV-monoinfected than HIV/HCV-coinfected (71% versus 56%; p = 0.038) and HIV-monoinfected (71% versus 50%; p = 0.035) patients. A previous diagnosis of arthritis and current smoking were risk factors for joint pain among HCV-infected patients (arthritis: aOR, 4.25; 95% CI, 1.84-9.81; smoking: aOR, 5.02; 95% CI, 2.15-11.74) and HIV-infected (arthritis: aOR, 5.36; 95% CI, 2.01-14.25; smoking: aOR, 6.07; 95% CI, 2.30-16.00) patients. Conclusion: Patient-reported joint pain was prevalent among all three groups, but more common among chronic HCV-monoinfected than either HIV/HCV-coinfected or HIV-monoinfected patients. A prior diagnosis of arthritis and current smoking were risk factors for patient-reported joint pain among both HCV-infected and HIV-infected patients. C1 [Ogdie, Alexis] Univ Penn, Perelman Sch Med, Ctr Clin Epidemiol & Biostat, Div Rheumatol, Philadelphia, PA 19104 USA. [Pang, Wyki Gina] Tufts Univ, Sch Med, Maine Med Ctr, Portland, ME USA. [Forde, Kimberly A.] Univ Penn, Perelman Sch Med, Ctr Clin Epidemiol & Biostat, Dept Med,Div Gastroenterol, Philadelphia, PA 19104 USA. [Samir, Bhangle D.] Seacoast Arthrit & Osteoporosis Ctr, Dover, NH 03820 USA. [Mulugeta, Lakeisha] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA. [Chang, Kyong-Mi; Kaplan, David E.] Univ Penn, Perelman Sch Med, Philadelphia VA Med Ctr, Div Gastroenterol, Philadelphia, PA 19104 USA. [Amorosa, Valerianna K.; Kostman, Jay R.] Univ Penn, Perelman Sch Med, Philadelphia VA Med Ctr, Div Infect Dis, Philadelphia, PA 19104 USA. [Reddy, Rajender K.] Univ Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA. [Schumacher, Ralph H.] Univ Penn, Perelman Sch Med, Philadelphia VA Med Ctr, Div Rheumatol, Philadelphia, PA 19104 USA. [Lo Re, Vincent, III] Univ Penn, Perelman Sch Med, Ctr Clin Epidemiol & Biostat, Dept Med,Div Infect Dis, Philadelphia, PA 19104 USA. RP Ogdie, A (reprint author), Univ Penn, Perelman Sch Med, Ctr Clin Epidemiol & Biostat, Div Rheumatol, Penn Tower Room 1407,1 Convent Ave, Philadelphia, PA 19104 USA. EM Alexis.ogdie@uphs.upenn.edu RI Lo Re, Vincent/N-7817-2015 OI Ogdie, Alexis/0000-0002-4639-0775 FU American College of Rheumatology Research Foundation Ephram Engleman Preceptorship Award; American College of Rheumatology Research Foundation Investigator Award; National Institute of Arthritis and Musculoskeletal and Skin Diseases [K23 AR063764]; National Institute of Allergy and Infectious Diseases [K01 AI 070001] FX We would like to thank Janet Dinella and Yihui Connie Jiang for administrative support and Melissa Nezamzadeh for assistance with database management. This study was funded by the American College of Rheumatology Research Foundation Ephram Engleman Preceptorship Award. During this study, Dr. Ogdie was supported by an American College of Rheumatology Research Foundation Investigator Award and research grant K23 AR063764 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and Dr. Lo Re was supported by research grant K01 AI 070001 from the National Institute of Allergy and Infectious Diseases. NR 31 TC 1 Z9 1 U1 2 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2474 J9 BMC MUSCULOSKEL DIS JI BMC Musculoskelet. Disord. PD APR 19 PY 2015 VL 16 AR 93 DI 10.1186/s12891-015-0552-z PG 8 WC Orthopedics; Rheumatology SC Orthopedics; Rheumatology GA CG3QB UT WOS:000353193600001 PM 25896674 ER PT J AU Gale, RC Asch, SM Taylor, T Nelson, KM Luck, J Meredith, LS Helfrich, CD AF Gale, Randall C. Asch, Steven M. Taylor, Thomas Nelson, Karin M. Luck, Jeff Meredith, Lisa S. Helfrich, Christian D. TI The most used and most helpful facilitators for patient-centered medical home implementation SO Implementation Science LA English DT Article DE Patient-centered medical home; Implementation resources; Provider self-efficacy ID PRIMARY-CARE; HEALTH; LESSONS; SUPPORT; HISTORY AB Background: Like other transformative healthcare initiatives, patient-centered medical home (PCMH) implementation requires substantial investments of time and resources. Even though PCMH and PCMH-like models are being implemented by multiple provider practices and health systems, little is known about what facilitates their implementation. The purpose of this study was to assess which PCMH-implementation resources are most widely used, by whom, and which resources primary care personnel find most helpful. Methods: This study is an analysis of data from a cross-sectional survey of primary care personnel in the Veterans Health Administration in 2012, in which respondents were asked to rate whether they were aware of and accessed PCMH-implementation resources, and to rate their helpfulness. Logistic regression was used to produce odds ratios for the outcomes (1) resource use and (2) resource helpfulness. Respondents were nested within clinics, nested, in turn, within 135 parent hospitals. Results: Teamlet huddles were the most widely accessed (80.4% accessed) and most helpful (90.4% rated helpful) resource; quality-improvement methods to conduct small tests of change were the least frequently accessed (42.4% accessed) resource though two-thirds (66.7%) of users reported as helpful. Supervisors were significantly more likely (ORs, 1.46 to 1.86) to use resources than non-supervisors but were less likely to rate the majority (8 out of 10) of resources as "somewhat/very helpful" than non-supervisors (ORs, 0.72 to 0.84). Longer-tenured employees tended to rate resources as more helpful. Conclusions: These findings are the first in the PCMH literature that we are aware of that systematically assesses primary care staff's access to and the helpfulness of PCMH implementation resources. Supervisors generally reported greater access to resources, relative to non-supervisors, but rated resources as less helpful, suggesting that information about them may not have been optimally disseminated. Knowing what resources primary care staff use and find helpful can inform administrators' and policymakers' investments in PCMH-implementation resources. The implications of our model extend beyond just PCMH implementation but also to considerations when providing implementation resources for other complex quality-improvement initiatives. C1 [Gale, Randall C.; Asch, Steven M.; Taylor, Thomas] Ctr Innovat Implementat Ci2i, VA Palo Alto Hlth Care Syst, Menlo Pk, CA 94025 USA. [Asch, Steven M.] Stanford Univ, Div Gen Med Disciplines, Palo Alto, CA 94304 USA. [Nelson, Karin M.; Helfrich, Christian D.] US Dept Vet Affairs, Seattle Denver Ctr Innovat Vet Ctr & Value Driven, Seattle, WA USA. [Nelson, Karin M.] Univ Washington, Sch Med, Dept Med, Seattle, WA 98195 USA. [Nelson, Karin M.; Helfrich, Christian D.] Univ Washington, Sch Publ Hlth, Dept Hlth Serv, Seattle, WA 98195 USA. [Luck, Jeff] Oregon State Univ, Coll Publ Hlth & Human Sci, Corvallis, OR 97331 USA. [Meredith, Lisa S.] VA HSR&D Ctr Study Healthcare Provider Behav, Sepulveda, CA USA. [Meredith, Lisa S.] RAND Corp, Santa Monica, CA USA. RP Gale, RC (reprint author), Ctr Innovat Implementat Ci2i, VA Palo Alto Hlth Care Syst, 790 Willow Rd, Menlo Pk, CA 94025 USA. EM Randall.Gale@va.gov NR 31 TC 2 Z9 2 U1 3 U2 7 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1748-5908 J9 IMPLEMENT SCI JI Implement. Sci. PD APR 19 PY 2015 VL 10 AR 52 DI 10.1186/s13012-015-0246-9 PG 11 WC Health Care Sciences & Services; Health Policy & Services SC Health Care Sciences & Services GA CG9RW UT WOS:000353657900001 PM 25924611 ER PT J AU Tang, V Boscardin, WJ Stijacic-Cenzer, I Lee, SJ AF Tang, Victoria Boscardin, W. John Stijacic-Cenzer, Irena Lee, Sei J. TI Time to benefit for colorectal cancer screening: survival meta-analysis of flexible sigmoidoscopy trials SO BMJ-British Medical Journal LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; OLDER-ADULTS; FOLLOW-UP; COLONOSCOPY; PREVENTION; MORTALITY AB OBJECTIVE To determine the time to benefit of using flexible sigmoidoscopy for colorectal cancer screening. DESIGN Survival meta-analysis. DATA SOURCES A Cochrane Collaboration systematic review published in 2013, Medline, and Cochrane Library databases. ELIGIBILITY CRITERIA Randomized controlled trials comparing screening flexible sigmoidoscopy with no screening. Trials with fewer than 100 flexible sigmoidoscopy screenings were excluded. RESULTS Four studies were eligible (total n=459 814). They were similar for patients' age (50-74 years), length of follow-up (11.2-11.9 years), and relative risk for colorectal cancer related mortality (0.69-0.78 with flexible sigmoidoscopy screening). For every 1000 people screened at five and 10 years, 0.3 and 1.2 colorectal cancer related deaths, respectively, were prevented. It took 4.3 years (95% confidence interval 2.8 to 5.8) to observe an absolute risk reduction of 0.0002 (one colorectal cancer related death prevented for every 5000 flexible sigmoidoscopy screenings). It took 9.4 years (7.6 to 11.3) to observe an absolute risk reduction of 0.001 (one colorectal cancer related death prevented for every 1000 flexible sigmoidoscopy screenings). CONCLUSION Our findings suggest that screening flexible sigmoidoscopy is most appropriate for older adults with a life expectancy greater than approximately 10 years. C1 [Tang, Victoria; Boscardin, W. John; Stijacic-Cenzer, Irena; Lee, Sei J.] San Francisco VA Med Ctr, San Francisco, CA 94121 USA. [Boscardin, W. John; Stijacic-Cenzer, Irena; Lee, Sei J.] Univ Calif San Francisco, Div Geriatr, San Francisco, CA 94143 USA. RP Tang, V (reprint author), San Francisco VA Med Ctr, San Francisco, CA 94121 USA. EM Victoria.Tang@ucsf.edu FU Beeson career development award through the American Federation of Aging Research; National Institute on Aging [K23AG040779] FX SJL was supported by the Beeson career development award through the American Federation of Aging Research and National Institute on Aging (K23AG040779). The funding source had no involvement in the design or conduct of the study and had no influence on the collection, analysis, and interpretation of the data; the preparation, review, or approval of the manuscript; or the decision to submit the paper for publication. NR 30 TC 5 Z9 5 U1 0 U2 0 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1756-1833 J9 BMJ-BRIT MED J JI BMJ-British Medical Journal PD APR 16 PY 2015 VL 350 AR h1662 DI 10.1136/bmj.h1662 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA CG5JV UT WOS:000353328700003 PM 25881903 ER PT J AU Brune, K Frank, J Schwingshackl, A Finigan, J Sidhaye, VK AF Brune, Kieran Frank, James Schwingshackl, Andreas Finigan, James Sidhaye, Venkataramana K. TI Pulmonary epithelial barrier function: some new players and mechanisms SO AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY LA English DT Review DE lung; epithelial barrier; permeability; transport; ions ID ACUTE LUNG INJURY; GROWTH-FACTOR RECEPTOR; RESPIRATORY-DISTRESS-SYNDROME; POTASSIUM CHANNEL TREK-1; NA-K-ATPASE; TRANSMEMBRANE CONDUCTANCE REGULATOR; HUMAN AIRWAY EPITHELIA; TIGHT JUNCTION PERMEABILITY; ALVEOLAR FLUID CLEARANCE; BETA-CATENIN AB The pulmonary epithelium serves as a barrier to prevent access of the inspired luminal contents to the subepithelium. In addition, the epithelium dictates the initial responses of the lung to both infectious and noninfectious stimuli. One mechanism by which the epithelium does this is by coordinating transport of diffusible molecules across the epithelial barrier, both through the cell and between cells. In this review, we will discuss a few emerging paradigms of permeability changes through altered ion transport and paracellular regulation by which the epithelium gates its response to potentially detrimental luminal stimuli. This review is a summary of talks presented during a symposium in Experimental Biology geared toward novel and less recognized methods of epithelial barrier regulation. First, we will discuss mechanisms of dynamic regulation of cell-cell contacts in the context of repetitive exposure to inhaled infectious and noninfectious insults. In the second section, we will briefly discuss mechanisms of transcellular ion homeostasis specifically focused on the role of claudins and paracellular ion-channel regulation in chronic barrier dysfunction. In the next section, we will address transcellular ion transport and highlight the role of Trek-1 in epithelial responses to lung injury. In the final section, we will outline the role of epithelial growth receptor in barrier regulation in baseline, acute lung injury, and airway disease. We will then end with a summary of mechanisms of epithelial control as well as discuss emerging paradigms of the epithelium role in shifting between a structural element that maintains tight cell-cell adhesion to a cell that initiates and participates in immune responses. C1 [Brune, Kieran; Sidhaye, Venkataramana K.] Johns Hopkins Univ, Div Pulm & Crit Care Med, Baltimore, MD USA. [Frank, James] Univ Calif San Francisco, San Francisco VA Med Ctr, Div Pulm & Crit Care Med, San Francisco, CA 94143 USA. [Frank, James] Vet Hlth Res Inst, NCIRE, San Francisco, CA 94143 USA. [Schwingshackl, Andreas] Univ Tennessee, Ctr Hlth Sci, Dept Pediat, Memphis, TN 38163 USA. [Finigan, James] Natl Jewish Hlth, Ctr Canc, Div Oncol, Denver, CO USA. RP Sidhaye, VK (reprint author), Johns Hopkins Asthma & Allergy Ctr, Div Pulm & Crit Care Med, Dept Med, 4B-59,5501 Hopkins Bayview Circle, Baltimore, MD 21224 USA. EM vsidhay1@jhmi.edu FU NHLBI NIH HHS [K08 HL118118, R01 HL111674, R21 HL111707, R56 HL088440] NR 212 TC 9 Z9 9 U1 4 U2 18 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 1040-0605 EI 1522-1504 J9 AM J PHYSIOL-LUNG C JI Am. J. Physiol.-Lung Cell. Mol. Physiol. PD APR 15 PY 2015 VL 308 IS 8 BP L731 EP L745 DI 10.1152/ajplung.00309.2014 PG 15 WC Physiology; Respiratory System SC Physiology; Respiratory System GA CH3JP UT WOS:000353927300001 PM 25637609 ER PT J AU Grazioli, S Gil, S An, D Kajikawa, O Farnand, AW Hanson, JF Birkland, T Chen, P Duffield, J Schnapp, LM Altemeier, WA Matute-Bello, G AF Grazioli, Serge Gil, Sucheol An, Dowon Kajikawa, Osamu Farnand, Alex W. Hanson, Josiah F. Birkland, Timothy Chen, Peter Duffield, Jeremy Schnapp, Lynn M. Altemeier, William A. Matute-Bello, Gustavo TI CYR61 (CCN1) overexpression induces lung injury in mice SO AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY LA English DT Article DE Cysteine-rich protein-61; CCN1; acute lung injury ID CELL-MIGRATION MODULATOR; IMMEDIATE-EARLY GENE; MATRICELLULAR PROTEINS; GROWTH-FACTOR; EPITHELIAL-CELLS; EXPRESSION; FIBROSIS; PROLIFERATION; ADHESION; INFLAMMATION AB Cysteine- rich protein-61 (CYR61), also known as connective tissue growth factor, CYR61, and nephroblastoma overexpressed gene 1 (CCN1), is a heparin-binding protein member of the CCN family of matricellular proteins. Gene expression profiles showed that Cyr61 is upregulated in human acute lung injury (ALI), but its functional role is unclear. We hypothesized that CYR61 contributes to ALI in mice. First, we demonstrated that CYR61 expression increases after bleomycin-induced lung injury. We then used adenovirus-mediated gene transfer to determine whether CYR61 overexpression in the lungs was sufficient to cause ALI. Mice instilled with CYR61 adenovirus showed greater weight loss, increased bronchoalveolar lavage total neutrophil counts, increased protein concentrations, and increased mortality compared with mice instilled with empty-vector adenovirus. Immunohistochemical studies in lungs from humans with idiopathic pulmonary fibrosis revealed CYR61 expression on the luminal membrane of alveolar epithelial cells in areas of injury. We conclude that CYR61 is upregulated in ALI and that CYR61 overexpression exacerbates ALI in mice. C1 [Grazioli, Serge] Univ Hosp Geneva, Pediat Crit Care Unit, Geneva, Switzerland. [Grazioli, Serge; Gil, Sucheol; An, Dowon; Kajikawa, Osamu; Farnand, Alex W.; Hanson, Josiah F.; Birkland, Timothy; Chen, Peter; Schnapp, Lynn M.; Altemeier, William A.; Matute-Bello, Gustavo] Univ Washington, Dept Med, Ctr Lung Biol, Div Pulm & Crit Med, Seattle, WA USA. [Duffield, Jeremy] Univ Washington, Dept Med, Div Nephrol, Seattle, WA USA. [Matute-Bello, Gustavo] Vet Affairs Puget Sound Healthcare Syst, Seattle, WA USA. RP Matute-Bello, G (reprint author), 850 Republican St,Box 358052, Seattle, WA 98109 USA. RI Grazioli, Serge/A-1457-2016 OI Chen, Peter/0000-0002-5330-1718 FU Swiss National Science Foundation [PBGEP3-142293]; NIH:NHLBI [HL081764]; NHLBI grant [HL086883, HL103868, HL120947] FX This work was supported by Swiss National Science Foundation Grant PBGEP3-142293 (S. Grazioli), NIH:NHLBI grant HL081764 (G. MatuteBello), NHLBI grant HL086883 (W. Altemeier), HL103868 (P. Chen), and HL120947 (P. Chen). NR 34 TC 4 Z9 4 U1 1 U2 5 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 1040-0605 EI 1522-1504 J9 AM J PHYSIOL-LUNG C JI Am. J. Physiol.-Lung Cell. Mol. Physiol. PD APR 15 PY 2015 VL 308 IS 8 BP L759 EP L765 DI 10.1152/ajplung.00190.2014 PG 7 WC Physiology; Respiratory System SC Physiology; Respiratory System GA CH3JP UT WOS:000353927300003 PM 25713320 ER PT J AU Bamman, MM Ferrando, AA Evans, RP Stec, MJ Kelly, NA Gruenwald, JM Corrick, KL Trump, JR Singh, JA AF Bamman, Marcas M. Ferrando, Arny A. Evans, Richard P. Stec, Michael J. Kelly, Neil A. Gruenwald, Johannes M. Corrick, Katie L. Trump, Jesse R. Singh, Jasvinder A. TI Muscle inflammation susceptibility: a prognostic index of recovery potential after hip arthroplasty? SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM LA English DT Article DE total hip arthroplasty; muscle atrophy; inflammation; muscle protein metabolism; muscle regeneration ID TOTAL KNEE ARTHROPLASTY; HUMAN SKELETAL-MUSCLE; PAIN MEDICATIONS; POOR PAIN; ATROPHY; REGENERATION; OSTEOARTHRITIS; PREDICTORS; EXPRESSION; CELLS AB While elective total hip arthroplasty (THA) for end-stage osteoarthritis (OA) improves pain, mobility function, and quality of life in most cases, a large proportion of patients suffer persistent muscle atrophy, pain, and mobility impairment. Extensive skeletal muscle damage is unavoidable in these surgical procedures, and it stands to reason that poor recovery and long-term mobility impairment among some individuals after THA is linked to failed muscle regeneration and regrowth following surgery and that local muscle inflammation susceptibility (MuIS) is a major contributing factor. Here we present results of two integrated studies. In study 1, we compared muscle inflammation and protein metabolism signaling in elective THA (n = 15) vs. hip fracture/trauma (HFX; n = 11) vs. nonsurgical controls (CON; n = 19). In study 2, we compared two subgroups of THA patients dichotomized into MuIS((+)) (n = 7) or MuIS((-)) (n = 7) based on muscle expression of TNF-like weak inducer of apoptosis (TWEAK) receptor (Fn14). As expected, HFX demonstrated overt systemic and local muscle inflammation and hypermetabolism. By contrast, no systemic inflammation was detected in elective THA patients; however, local muscle inflammation in the perioperative limb was profound in MuIS((+)) and was accompanied by suppressed muscle protein synthesis compared with MuIS((-)). Muscle from the contralateral limb of MuIS((+)) was unaffected, providing evidence of a true inflammation susceptibility localized to the muscle surrounding the hip with end-stage OA. We suggest MuIS status assessed at the time of surgery may be a useful prognostic index for muscle recovery potential and could therefore provide the basis for a personalized approach to postsurgery rehabilitation. C1 [Bamman, Marcas M.; Stec, Michael J.; Kelly, Neil A.; Corrick, Katie L.; Trump, Jesse R.] Univ Alabama Birmingham, Dept Cell Dev & Integrat Biol, Birmingham, AL 35294 USA. [Ferrando, Arny A.] Univ Arkansas Med Sci, Dept Geriatr, Little Rock, AR 72205 USA. [Ferrando, Arny A.] Univ Arkansas Med Sci, Ctr Translat Res Aging & Longev, Little Rock, AR 72205 USA. [Evans, Richard P.] Univ Arkansas Med Sci, Dept Orthoped Surg, Little Rock, AR 72205 USA. [Gruenwald, Johannes M.] Univ Arkansas Med Sci, Dept Trauma Surg, Little Rock, AR 72205 USA. [Singh, Jasvinder A.] Univ Alabama Birmingham, Dept Med, Div Clin Immunol & Rheumatol, Birmingham, AL 35294 USA. [Bamman, Marcas M.; Stec, Michael J.; Kelly, Neil A.; Singh, Jasvinder A.] Univ Alabama Birmingham, UAB Ctr Exercise Med, Birmingham, AL 35294 USA. [Bamman, Marcas M.; Singh, Jasvinder A.] Univ Alabama Birmingham, Comprehens Arthrit Musculoskeletal & Autoimmun Ct, Birmingham, AL 35294 USA. [Bamman, Marcas M.] Birmingham Vet Affairs Med Ctr, Geriatr Res Educ & Clin Ctr, Birmingham, AL USA. [Singh, Jasvinder A.] Birmingham Vet Affairs Med Ctr, Med Serv, Birmingham, AL USA. [Singh, Jasvinder A.] Mayo Clin, Coll Med, Rochester, MN USA. RP Bamman, MM (reprint author), Univ Alabama Birmingham, UAB Ctr Exercise Med, MCLM 966,1918 Univ Blvd, Birmingham, AL 35294 USA. EM mbamman@uab.edu FU National Institutes of Health [R01-AR-052293, P30-AG-028718]; Veterans Affairs Merit Review Award; UAB Center for Exercise Medicine Core Muscle Research Laboratory FX The research was supported in part by National Institutes of Health Grants R01-AR-052293 (to A. A. Ferrando) and P30-AG-028718 (to A. A. Ferrando), a Veterans Affairs Merit Review Award (to M. M. Bamman), and the UAB Center for Exercise Medicine Core Muscle Research Laboratory (to M. M. Bamman). NR 35 TC 2 Z9 2 U1 0 U2 10 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0193-1849 EI 1522-1555 J9 AM J PHYSIOL-ENDOC M JI Am. J. Physiol.-Endocrinol. Metab. PD APR 15 PY 2015 VL 308 IS 8 BP E670 EP E679 DI 10.1152/ajpendo.00576.2014 PG 10 WC Endocrinology & Metabolism; Physiology SC Endocrinology & Metabolism; Physiology GA CH3SS UT WOS:000353951200007 PM 25670829 ER PT J AU Sakely, H Corbo, J Coley, K McGivney, M Thorpe, C Klatt, P Schleiden, L Zaharoff, J Cox-Vance, L Balestrino, V AF Sakely, Heather Corbo, Jason Coley, Kim McGivney, Melissa Thorpe, Carolyn Klatt, Patricia Schleiden, Loren Zaharoff, John Cox-Vance, Lora Balestrino, Vincent TI Pharmacist-led collaborative practice for older adults SO AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY LA English DT Editorial Material ID MEDICATION USE; CARE; RECONCILIATION C1 [Sakely, Heather] UPMC St Margaret, Geriatr Pharmacotherapy, Pittsburgh, PA 15215 USA. [Corbo, Jason] UPMC St Margaret, Geriatr, Pittsburgh, PA 15215 USA. [Coley, Kim] Univ Pittsburgh, Sch Pharm, Dept Pharm & Therapeut, Pittsburgh, PA 15261 USA. [McGivney, Melissa] Univ Pittsburgh, Sch Pharm, Community Partnerships, Pittsburgh, PA 15260 USA. [McGivney, Melissa] Univ Pittsburgh, Sch Pharm, Pharm & Therapeut, Pittsburgh, PA 15260 USA. [Thorpe, Carolyn] Vet Affairs Pittsburgh Healthcare Syst, Ctr Hlth Equ Res & Promot, Pittsburgh, PA USA. [Thorpe, Carolyn] Univ Pittsburgh, Sch Pharm, Pharm & Therapeut, Pittsburgh, PA 15260 USA. [Klatt, Patricia] UPMC St Margaret, Adv Pharmacist Practice, Pittsburgh, PA USA. [Schleiden, Loren] Univ Pittsburgh, Sch Pharm, Pittsburgh, PA 15260 USA. [Zaharoff, John] Willows, Presbyterian SeniorCare, Oakmont, PA USA. [Cox-Vance, Lora] UPMC St Margaret, Geriatr Fellowship, Pittsburgh, PA USA. [Balestrino, Vincent] UPMC St Margaret, Family Med Residency, Pittsburgh, PA USA. RP Sakely, H (reprint author), UPMC St Margaret, Geriatr Pharmacotherapy, Pittsburgh, PA 15215 USA. EM sakelyh@upmc.edu OI Coley, Kim/0000-0002-5454-5300 NR 11 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEALTH-SYSTEM PHARMACISTS PI BETHESDA PA 7272 WISCONSIN AVE, BETHESDA, MD 20814 USA SN 1079-2082 EI 1535-2900 J9 AM J HEALTH-SYST PH JI Am. J. Health-Syst. Pharm. PD APR 15 PY 2015 VL 72 IS 8 BP 606 EP + DI 10.2146/ajhp140228 PG 3 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA CG2BH UT WOS:000353079400008 PM 25825181 ER PT J AU Lombardi, AJ Hoskins, EE Foglesong, GD Wikenheiser-Brokamp, KA Wiesmuller, L Hanenberg, H Andreassen, PR Jacobs, AJ Olson, SB Keeble, WW Hays, LE Wells, SI AF Lombardi, Anne J. Hoskins, Elizabeth E. Foglesong, Grant D. Wikenheiser-Brokamp, Kathryn A. Wiesmueller, Lisa Hanenberg, Helmut Andreassen, Paul R. Jacobs, Allison J. Olson, Susan B. Keeble, Winifred W. Hays, Laura E. Wells, Susanne I. TI Acquisition of Relative Interstrand Crosslinker Resistance and PARP Inhibitor Sensitivity in Fanconi Anemia Head and Neck Cancers SO CLINICAL CANCER RESEARCH LA English DT Article ID SQUAMOUS-CELL CARCINOMA; DOUBLE-STRAND BREAKS; DNA-DAMAGE RESPONSE; POLY(ADP-RIBOSE) POLYMERASE-1; CLINICAL RADIOSENSITIVITY; SYNTHETIC LETHALITY; REPAIR; PATHWAY; TRANSCRIPTION; DEFICIENCY AB Purpose: Fanconi anemia is an inherited disorder associated with a constitutional defect in the Fanconi anemia DNA repair machinery that is essential for resolution of DNA interstrand crosslinks. Individuals with Fanconi anemia are predisposed to formation of head and neck squamous cell carcinomas (HNSCC) at a young age. Prognosis is poor, partly due to patient intolerance of chemotherapy and radiation requiring dose reduction, which may lead to early recurrence of disease. Experimental Design: Using HNSCC cell lines derived from the tumors of patients with Fanconi anemia, and murine HNSCC cell lines derived from the tumors of wild-type and Fancc(-/)-mice, we sought to define Fanconi anemia-dependent chemosensitivity and DNA repair characteristics. We utilized DNA repair reporter assays to explore the preference of Fanconi anemia HNSCC cells for non-homologous end joining (NHEJ). Results: Surprisingly, interstrand crosslinker (ICL) sensitivity was notnecessarily Fanconi anemia-dependent inhuman or murine cell systems. Our results suggest that the increased Ku-dependent NHEJ that is expected in Fanconi anemia cells did not mediate relative ICL resistance. ICL exposure resulted in increased DNA damage sensing and repair by PARP in Fanconi anemia-deficient cells. Moreover, human and murine Fanconi anemia HNSCC cells were sensitive to PARP inhibition, and sensitivity of human cells was attenuated by Fanconi anemia gene complementation. Conclusions: The observed reliance upon PARP-mediated mechanisms reveals a means by which Fanconi anemia HNSCCs can acquire relative resistance to the ICL-based chemotherapy that is a foundation of HNSCC treatment, as well as a potential target for overcoming chemoresistance in the chemosensitive individual. C1 [Lombardi, Anne J.; Hoskins, Elizabeth E.; Foglesong, Grant D.; Andreassen, Paul R.; Wells, Susanne I.] Cincinnati Childrens Hosp Res Fdn, Canc & Blood Dis Inst, Cincinnati, OH 45229 USA. [Wikenheiser-Brokamp, Kathryn A.] Cincinnati Childrens Hosp Med Ctr, Pathol & Lab Med, Cincinnati, OH 45229 USA. [Wikenheiser-Brokamp, Kathryn A.] Cincinnati Childrens Hosp Med Ctr, Pulm Biol, Cincinnati, OH 45229 USA. [Wikenheiser-Brokamp, Kathryn A.] Univ Cincinnati, Cincinnati, OH USA. [Wiesmueller, Lisa] Univ Ulm, Dept Obstet & Gynaecol, D-89069 Ulm, Germany. [Hanenberg, Helmut] Indiana Univ Sch Med, Dept Pediat & Med & Mol Genet, Indianapolis, IN 46202 USA. [Hanenberg, Helmut] Univ Dusseldorf, Sch Med, Dept Otorhinolaryngol ENT HNO, Dusseldorf, Germany. [Jacobs, Allison J.; Keeble, Winifred W.; Hays, Laura E.] Oregon Hlth & Sci Univ, Knight Canc Inst, Dept Hematol Oncol, Portland, OR 97201 USA. [Jacobs, Allison J.; Keeble, Winifred W.; Hays, Laura E.] Portland VA Med Ctr, Portland, OR USA. [Olson, Susan B.] Oregon Hlth & Sci Univ, Dept Mol & Med Genet, Portland, OR 97201 USA. RP Wells, SI (reprint author), Cincinnati Childrens Hosp Res Fdn, Room S7-206 MLC 7015,3333 Burnet Ave, Cincinnati, OH 45229 USA. EM laura@fanconi.org; susanne.wells@cchmc.org FU NIH [RO1 CA102357]; NHLBI [PO1HL048546]; Fanconi Anemia Research Fund FX This work was supported in part by NIH award RO1 CA102357 (to S.I. Wells), NHLBI grant PO1HL048546 (to S.B. Olson), and a grant from the Fanconi Anemia Research Fund (to L.E. Hays). NR 50 TC 2 Z9 2 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1078-0432 EI 1557-3265 J9 CLIN CANCER RES JI Clin. Cancer Res. PD APR 15 PY 2015 VL 21 IS 8 BP 1962 EP 1972 DI 10.1158/1078-0432.CCR-14-2616 PG 11 WC Oncology SC Oncology GA CF9PJ UT WOS:000352897200025 PM 25609062 ER PT J AU Robertson, CL Ishibashi, K Mandelkern, MA Brown, AK Ghahremani, DG Sabb, F Bilder, R Cannon, T Borg, J London, ED AF Robertson, Chelsea L. Ishibashi, Kenji Mandelkern, Mark A. Brown, Amira K. Ghahremani, Dara G. Sabb, Fred Bilder, Robert Cannon, Tyrone Borg, Jacqueline London, Edythe D. TI Striatal D-1- and D-2-type Dopamine Receptors Are Linked to Motor Response Inhibition in Human Subjects SO JOURNAL OF NEUROSCIENCE LA English DT Article DE dopamine; impulsivity; PET imaging ID REACTION-TIME-TASK; STOP-SIGNAL TASK; TEST-RETEST RELIABILITY; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY DISORDER; NUCLEUS-ACCUMBENS CORE; REFERENCE TISSUE MODEL; IMPULSIVE BEHAVIOR; BASAL GANGLIA; PREFRONTAL CORTEX AB Motor response inhibition is mediated by neural circuits involving dopaminergic transmission; however, the relative contributions of dopaminergic signaling via D-1- and D-2-type receptors are unclear. Although evidence supports dissociable contributions of D-1- and D-2-type receptors to response inhibition in rats and associations of D-2-type receptors to response inhibition in humans, the relationship between D-1-type receptors and response inhibition has not been evaluated in humans. Here, we tested whether individual differences in striatal D-1- and D-2-type receptors are related to response inhibition in human subjects, possibly in opposing ways. Thirty-one volunteers participated. Response inhibition was indexed by stop-signal reaction time on the stop-signal task and commission errors on the continuous performance task, and tested for association with striatal D-1- and D-2-type receptor availability [binding potential referred to nondisplaceable uptake (BPND)], measured using positron emission tomography with [C-11]NNC-112 and [F-18] fallypride, respectively. Stop-signal reaction time was negatively correlated with D-1- and D-2-type BPND in whole striatum, with significant relationships involving the dorsal striatum, but not the ventral striatum, and no significant correlations involving the continuous performance task. The results indicate that dopamine D-1- and D-2-type receptors are associated with response inhibition, and identify the dorsal striatum as an important locus of dopaminergic control in stopping. Moreover, the similar contribution of both receptor subtypes suggests the importance of a relative balance between phasic and tonic dopaminergic activity subserved by D-1- and D-2-type receptors, respectively, in support of response inhibition. The results also suggest that the stop-signal task and the continuous performance task use different neurochemical mechanisms subserving motor response inhibition. C1 [Robertson, Chelsea L.; London, Edythe D.] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Dept Mol & Med Pharmacol, Los Angeles, CA 90024 USA. [Cannon, Tyrone; Borg, Jacqueline] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Dept Psychol, Los Angeles, CA 90024 USA. [Ishibashi, Kenji; Brown, Amira K.; Ghahremani, Dara G.; Sabb, Fred; Bilder, Robert; London, Edythe D.] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA. [Ishibashi, Kenji; London, Edythe D.] Univ Calif Los Angeles, Brain Res Inst, Los Angeles, CA 90024 USA. [Robertson, Chelsea L.; Mandelkern, Mark A.; London, Edythe D.] Vet Adm Greater Los Angeles Healthcare Syst, Los Angeles, CA 90073 USA. [Mandelkern, Mark A.] Univ Calif Irvine, Dept Phys, Irvine, CA 92697 USA. RP London, ED (reprint author), Univ Calif Los Angeles, Semel Inst, 760 Westwood Plaza,C8-831, Los Angeles, CA 90024 USA. EM elondon@mednet.ucla.edu RI Bilder, Robert/A-8894-2008 OI Bilder, Robert/0000-0001-5085-7852 FU Consortium for Neuropsychiatric Phenomics (National Institutes of Health Roadmap for Medical Research) [UL1-DE019580, RL1MH083269, RL1DA024853, PL1MH083271]; UCLA Training Program in Translational Neuroscience of Drug Abuse [T32DA024635]; Marjorie Greene Trust FX This work was supported by the Consortium for Neuropsychiatric Phenomics (National Institutes of Health Roadmap for Medical Research Grants UL1-DE019580, RL1MH083269, RL1DA024853, and PL1MH083271), The UCLA Training Program in Translational Neuroscience of Drug Abuse (Grant T32DA024635), and Endowments from the Thomas P. and Katherine P. Pike Chair in Addiction Studies and the Marjorie Greene Trust. NR 80 TC 7 Z9 7 U1 3 U2 16 PU SOC NEUROSCIENCE PI WASHINGTON PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA SN 0270-6474 J9 J NEUROSCI JI J. Neurosci. PD APR 15 PY 2015 VL 35 IS 15 BP 5990 EP 5997 DI 10.1523/JNEUROSCI.4850-14.2015 PG 8 WC Neurosciences SC Neurosciences & Neurology GA CG1SZ UT WOS:000353055600011 PM 25878272 ER PT J AU Biundo, R Weis, L Facchini, S Formento-Dojot, P Vallelunga, A Pilleri, M Weintraub, D Antonini, A AF Biundo, Roberta Weis, Luca Facchini, Silvia Formento-Dojot, Patrizia Vallelunga, Annamaria Pilleri, Manuela Weintraub, Daniel Antonini, Angelo TI Patterns of Cortical Thickness Associated With Impulse Control Disorders in Parkinson's Disease SO MOVEMENT DISORDERS LA English DT Article DE Parkinson's disease; impulse control disorders; fronto-striatal-limbic networks; QUIP-RS; cortical thickness ID VENTROMEDIAL PREFRONTAL CORTEX; OBSESSIVE-COMPULSIVE DISORDER; MILD COGNITIVE IMPAIRMENT; SURFACE-BASED ANALYSIS; SOCIETY TASK-FORCE; RATING-SCALE; DOPAMINE-AGONISTS; DECISION-MAKING; CONNECTIVITY; BEHAVIOR AB Previous functional neuroimaging studies in Parkinson's disease (PD) patients with impulse control disorders (ICDs) demonstrated dysfunction of the reward network, although the extent of anatomical changes is unclear. The aim of this study was to measure brain cortical thickness and subcortical volumes, and to assess their relationship with presence and severity of symptoms, in PD patients with and without ICDs. We studied 110 PD patients (N=58 with ICDs) and 33 healthy controls (all negative for ICDs) who underwent an extensive neurological, neuropsychological, and behavioral assessment as well as structural 1.5 Tesla magnetic resonance imaging (MRI). Between-group differences in brain cortical thickness and subcortical volumes, assessed with the FreeSurfer 5.1 tool, were analyzed. In patients with ICDs, we found significant cortical thinning in fronto-striatal circuitry, specifically in the right superior orbitofrontal, left rostral middle frontal, bilateral caudal middle frontal region, and corpus callosum, as well as volume reduction in the right accumbens and increase in the left amygdala. Finally, we observed a positive association relationship between severity of impulsive symptoms and left rostral middle frontal, inferior parietal, and supramarginal areas. These results support the involvement of both reward and response inhibition networks in PD patients with ICDs. Moreover, their severity is associated with alterations in brain regions linked with reward and top-down control networks. Increased understanding of the mechanisms underlying impulsive and compulsive behaviors might help improve therapeutic strategies for these important disorders. (c) 2015 International Parkinson and Movement Disorder Society C1 [Biundo, Roberta; Weis, Luca; Facchini, Silvia; Formento-Dojot, Patrizia; Vallelunga, Annamaria; Pilleri, Manuela; Antonini, Angelo] Fdn Osped San Camillo IRCCS, Parkinson & Movement Disorders Unit, Venice, Italy. [Weintraub, Daniel] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA. [Weintraub, Daniel] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA. [Weintraub, Daniel] Philadelphia Vet Affairs Med Ctr, Parkinsons Dis Res Educ & Clin Ctr PADRECC, Philadelphia, PA USA. [Weintraub, Daniel] Philadelphia Vet Affairs Med Ctr, MIRECC, Philadelphia, PA USA. RP Biundo, R (reprint author), Fdn Osped San Camillo IRCCS, Parkinson & Movement Disorders Unit, Via Alberoni 70, I-30126 Venice Lido, Italy. EM roberta.biundo@ospedalesancamillo.net FU Italian Research Grant [N RF-2009-1530177] FX This study was supported by Italian Research Grant N RF-2009-1530177. NR 45 TC 12 Z9 12 U1 3 U2 12 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0885-3185 EI 1531-8257 J9 MOVEMENT DISORD JI Mov. Disord. PD APR 15 PY 2015 VL 30 IS 5 BP 688 EP 695 DI 10.1002/mds.26154 PG 8 WC Clinical Neurology SC Neurosciences & Neurology GA CF8FE UT WOS:000352790700013 PM 25649923 ER PT J AU Srivatsal, S Cholerton, B Leverenz, JB Wszolek, ZK Uitti, RJ Dickson, DW Weintraub, D Trojanowski, JQ Van Deerlin, VM Quinn, JF Chung, KA Peterson, AL Factor, SA Wood-Siverio, C Goldman, JG Stebbins, GT Bernard, B Ritz, B Rausch, R Espay, AJ Revilla, FJ Devoto, J Rosenthal, LS Dawson, TM Albert, MS Mata, IF Hu, SC Montine, KS Johnson, C Montine, TJ Edwards, KL Zhang, J Zabetian, CP AF Srivatsal, Sindhu Cholerton, Brenna Leverenz, James B. Wszolek, Zbigniew K. Uitti, Ryan J. Dickson, Dennis W. Weintraub, Daniel Trojanowski, John Q. Van Deerlin, Vivianna M. Quinn, Joseph F. Chung, Kathryn A. Peterson, Amie L. Factor, Stewart A. Wood-Siverio, Cathy Goldman, Jennifer G. Stebbins, Glenn T. Bernard, Bryan Ritz, Beate Rausch, Rebecca Espay, Alberto J. Revilla, Fredy J. Devoto, Johnna Rosenthal, Liana S. Dawson, Ted M. Albert, Marilyn S. Mata, Ignacio F. Hu, Shu-Ching Montine, Kathleen S. Johnson, Catherine Montine, Thomas J. Edwards, Karen L. Zhang, Jing Zabetian, Cyrus P. TI Cognitive Profile of LRRK2-Related Parkinson's Disease SO MOVEMENT DISORDERS LA English DT Article DE cognition; LRRK2; neuropsychological tests; Parkinson's disease; working memory ID MINI-MENTAL-STATE; LRRK2 MUTATIONS; NORMATIVE DATA; DEMENTIA; PERFORMANCE; IMPAIRMENT; ONSET; RISK; DYSFUNCTION; CARRIERS AB BackgroundIncreasing evidence suggests that genetic factors play a role in the variability associated with cognitive performance in Parkinson's disease (PD). Mutations in the LRRK2 gene are the most common cause of monogenic PD; however, the cognitive profile of LRRK2-related PD is not well-characterized. MethodsA cohort of 1,447 PD patients enrolled in the PD Cognitive Genetics Consortium was screened for LRRK2 mutations and completed detailed cognitive testing. Associations between mutation carrier status and cognitive test scores were assessed using linear regression models. ResultsLRRK2 mutation carriers (n=29) demonstrated better performance on the Mini Mental State Examination (P=0.03) and the Letter-Number Sequencing Test (P=0.005). A smaller proportion of LRRK2 carriers were demented (P=0.03). ConclusionsOur cross-sectional study demonstrates better performance on certain cognitive tests, as well as lower rates of dementia in LRRK2-related PD. Future longitudinal studies are needed to determine whether LRRK2 mutation carriers exhibit slower cognitive decline. (c) 2015 International Parkinson and Movement Disorder Society C1 [Srivatsal, Sindhu] Virginia Mason Neurosci Inst, Seattle, WA USA. [Cholerton, Brenna; Mata, Ignacio F.; Hu, Shu-Ching; Zabetian, Cyrus P.] VA Puget Sound Hlth Care Syst, Seattle, WA 98108 USA. [Cholerton, Brenna] Univ Washington, Sch Med, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [Leverenz, James B.] Cleveland Clin, Neurol Inst, Lou Ruvo Ctr Brain Hlth, Cleveland, OH 44106 USA. [Wszolek, Zbigniew K.; Uitti, Ryan J.; Dickson, Dennis W.] Mayo Clin, Dept Neurol, Jacksonville, FL 32224 USA. [Weintraub, Daniel] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA. [Weintraub, Daniel] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA. [Weintraub, Daniel] Philadelphia Vet Affairs Med Ctr, Philadelphia, PA USA. [Trojanowski, John Q.; Van Deerlin, Vivianna M.] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA USA. [Trojanowski, John Q.] Univ Penn, Inst Aging, Philadelphia, PA 19104 USA. [Quinn, Joseph F.; Chung, Kathryn A.; Peterson, Amie L.] Portland VA Med Ctr, Portland, OR USA. [Quinn, Joseph F.; Chung, Kathryn A.; Peterson, Amie L.] Oregon Hlth & Sci Univ, Dept Neurol, Portland, OR 97201 USA. [Factor, Stewart A.; Wood-Siverio, Cathy] Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA. [Goldman, Jennifer G.; Stebbins, Glenn T.; Bernard, Bryan] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA. [Ritz, Beate] Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90024 USA. [Ritz, Beate] Univ Calif Los Angeles, Sch Publ Hlth, Dept Environm Hlth Sci, Los Angeles, CA 90024 USA. [Ritz, Beate; Rausch, Rebecca] Univ Calif Los Angeles, Sch Med, Dept Neurol, Los Angeles, CA 90024 USA. [Espay, Alberto J.; Revilla, Fredy J.; Devoto, Johnna] Univ Cincinnati, Dept Neurol & Rehabil Med, Cincinnati, OH USA. [Rosenthal, Liana S.; Dawson, Ted M.; Albert, Marilyn S.] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA. [Dawson, Ted M.] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Neuroregenerat Program, Baltimore, MD USA. [Dawson, Ted M.] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Stem Cell Program, Baltimore, MD USA. [Dawson, Ted M.] Johns Hopkins Univ, Sch Med, Solomon H Snyder Dept Neurosci, Baltimore, MD USA. [Hu, Shu-Ching; Zabetian, Cyrus P.] Univ Washington, Sch Med, Dept Neurol, Seattle, WA USA. [Montine, Kathleen S.; Montine, Thomas J.; Zhang, Jing] Univ Washington, Sch Med, Dept Pathol, Seattle, WA 98195 USA. [Johnson, Catherine; Edwards, Karen L.] Univ Calif Irvine, Sch Med, Dept Epidemiol, Irvine, CA 92717 USA. RP Zabetian, CP (reprint author), VA Puget Sound Hlth Care Syst, GRECC S-182,1660 S Columbian Way, Seattle, WA 98108 USA. EM zabetian@u.washington.edu RI Ritz, Beate/E-3043-2015 FU National Institutes of Health [K23 NS060949, P50 NS062684, P50 NS053488, P50 NS038367, P50 NS038377, P50 NSO72187, R01 NS065070, R01 NS057567, U01 NS082133]; U.S. Department of Veterans Affairs Merit Award [1I01BX000531]; Parkinson's Disease Foundation; Nancy and Buster Alvord Endowment; Jane and Lee Seidman Fund; Consolidated Anti-Aging Foundation FX This research was supported by the National Institutes of Health (K23 NS060949, P50 NS062684, P50 NS053488, P50 NS038367, P50 NS038377, P50 NSO72187, R01 NS065070, R01 NS057567, and U01 NS082133), the U.S. Department of Veterans Affairs Merit Award (1I01BX000531), the Parkinson's Disease Foundation, the Nancy and Buster Alvord Endowment, the Jane and Lee Seidman Fund, the Consolidated Anti-Aging Foundation, and gifts from Carl Edward Bolch, Jr, and Susan Bass Bolch. The funding sources did not provide scientific input for the study. The contents of this article do not represent the views of the U.S. Department of Veterans Affairs or the United States Government. NR 37 TC 14 Z9 14 U1 0 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0885-3185 EI 1531-8257 J9 MOVEMENT DISORD JI Mov. Disord. PD APR 15 PY 2015 VL 30 IS 5 BP 728 EP 733 DI 10.1002/mds.26161 PG 6 WC Clinical Neurology SC Neurosciences & Neurology GA CF8FE UT WOS:000352790700019 PM 25650144 ER PT J AU Dawes, AJ Hemmelgarn, M Nguyen, DK Sacks, GD Clayton, SM Cope, JR Ganz, PA Maggard-Gibbons, M AF Dawes, Aaron J. Hemmelgarn, Marian Nguyen, David K. Sacks, Greg D. Clayton, Sheilah M. Cope, Jacqueline R. Ganz, Patricia A. Maggard-Gibbons, Melinda TI Are Primary Care Providers Prepared to Care for Survivors of Breast Cancer in the Safety Net? SO CANCER LA English DT Article DE breast cancer; survivorship; safety-net providers; primary care physicians ID QUALITY-OF-LIFE; TOP 5 LIST; FOLLOW-UP; CLINICAL ONCOLOGY; AMERICAN SOCIETY; RANDOMIZED-TRIAL; PHYSICIANS; SURVEILLANCE; MAMMOGRAPHY; PLANS AB BACKGROUNDWith the growing number of survivors of breast cancer outpacing the capacity of oncology providers, there is pressure to transition patients back to primary care. Primary care providers (PCPs) working in safety-net settings may have less experience treating survivors, and little is known about their knowledge and views on survivorship care. The current study was performed to determine the knowledge, attitudes, and confidence of PCPs in the safety net at delivering care to survivors of breast cancer. METHODSA modified version of the National Cancer Institute's Survey of Physician Attitudes Regarding Care of Cancer Survivors was given to providers at 2 county hospitals and 5 associated clinics (59 providers). Focus groups were held to understand barriers to survivorship care. RESULTSAlthough the majority of providers believed PCPs have the skills necessary to provide cancer-related follow-up, the vast majority were not comfortable providing these services themselves. Providers were adherent to American Society of Clinical Oncology recommendations for mammography (98%) and physical examination (87%); less than one-third were guideline-concordant for laboratory testing and only 6 providers (10%) met all recommendations. PCPs universally requested additional training on clinical guidelines and the provision of written survivorship care plans before transfer. Concerns voiced in qualitative sessions included unfamiliarity with the management of endocrine therapy and confusion regarding who would be responsible for certain aspects of care. CONCLUSIONSSafety-net providers currently lack knowledge of and confidence in providing survivorship care to patients with breast cancer. Opportunities exist for additional training in evidence-based guidelines and improved coordination of care between PCPs and oncology specialists. Cancer 2015;121:1249-1256. (c) 2014 American Cancer Society. Primary care providers working in safety-net settings report low knowledge and confidence in their ability to care for survivors of breast cancer. Additional training concerning aspects of survivorship care, including compliance with American Society of Clinical Oncology guidelines, is needed before survivors can be successfully transitioned to primary care. C1 [Dawes, Aaron J.; Nguyen, David K.; Sacks, Greg D.; Maggard-Gibbons, Melinda] Univ Calif Los Angeles, David Geffen Sch Med, Dept Surg, Los Angeles, CA 90095 USA. [Dawes, Aaron J.; Maggard-Gibbons, Melinda] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. [Dawes, Aaron J.; Sacks, Greg D.] Univ Calif Los Angeles, Robert Wood Johnson Fdn, Clin Scholars Program, Los Angeles, CA USA. [Hemmelgarn, Marian; Maggard-Gibbons, Melinda] Olive View Univ Calif Los Angeles, Med Ctr, Dept Surg, Sylmar, CA USA. [Clayton, Sheilah M.] Martin Luther King Jr Charles R Drew Univ Med Ctr, Dept Med, Div Canc Res & Training, Los Angeles, CA USA. [Clayton, Sheilah M.] Martin Luther King Jr Multi Serv Ambulatory Care, Los Angeles, CA USA. [Cope, Jacqueline R.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Family Med, Los Angeles, CA 90095 USA. [Cope, Jacqueline R.] Los Angeles Cty Dept Hlth Serv, Ambulatory Care Network, Los Angeles, CA USA. [Ganz, Patricia A.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA. [Ganz, Patricia A.] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90024 USA. RP Dawes, AJ (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Dept Surg, Ronald Reagan UCLA Med Ctr, 757 Westwood Plaza,B711, Los Angeles, CA 90095 USA. EM adawes@mednet.ucla.edu1 OI Dawes, Aaron/0000-0003-4574-6765 FU National Cancer Institute/National Institutes of Health [U54 CA143931] FX Supported in part by a grant from the National Cancer Institute/National Institutes of Health (U54 CA143931). NR 24 TC 9 Z9 9 U1 1 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0008-543X EI 1097-0142 J9 CANCER-AM CANCER SOC JI Cancer PD APR 15 PY 2015 VL 121 IS 8 BP 1249 EP 1256 DI 10.1002/cncr.29201 PG 8 WC Oncology SC Oncology GA CF7CG UT WOS:000352713100018 PM 25536301 ER PT J AU Zaynagetdinov, R Sherrill, TP Gleaves, LA McLoed, AG Saxon, JA Habermann, AC Connelly, L Dulek, D Peebles, RS Fingleton, B Yull, FE Stathopoulos, GT Blackwell, TS AF Zaynagetdinov, Rinat Sherrill, Taylor P. Gleaves, Linda A. McLoed, Allyson G. Saxon, Jamie A. Habermann, Arun C. Connelly, Linda Dulek, Daniel Peebles, R. Stokes, Jr. Fingleton, Barbara Yull, Fiona E. Stathopoulos, Georgios T. Blackwell, Timothy S. TI Interleukin-5 Facilitates Lung Metastasis by Modulating the Immune Microenvironment SO CANCER RESEARCH LA English DT Article ID REGULATORY T-CELLS; INNATE LYMPHOID-CELLS; FACTOR-KAPPA-B; AIRWAY HYPERRESPONSIVENESS; EXCESSIVE EOSINOPHILIA; TISSUE EOSINOPHILIA; CANCER METASTASIS; FLOW-CYTOMETRY; ASTHMA MODEL; IN-VIVO AB Although the lung is the most common metastatic site for cancer cells, biologic mechanisms regulating lung metastasis are not fully understood. Using heterotopic and intravenous injection models of lung metastasis in mice, we found that IL5, a cytokine involved in allergic and infectious diseases, facilitates metastatic colonization through recruitment of sentinel eosinophils and regulation of other inflammatory/immune cells in the microenvironment of the distal lung. Genetic IL5 deficiency offered marked protection of the lungs from metastasis of different types of tumor cells, including lung cancer, melanoma, and colon cancer. IL5 neutralization protected subjects from metastasis, whereas IL5 reconstitution or adoptive transfer of eosinophils into IL5-deficient mice exerted prometastatic effects. However, IL5 deficiency did not affect the growth of the primary tumor or the size of metastatic lesions. Mechanistic investigations revealed that eosinophils produce CCL22, which recruits regulatory T cells to the lungs. During early stages of metastasis, Treg created a protumorigenic microenvironment, potentially by suppressing IFN?-producing natural killer cells and M1-polarized macrophages. Together, our results establish a network of allergic inflammatory circuitry that can be co-opted by metastatic cancer cells to facilitate lung colonization, suggesting interventions to target this pathway may offer therapeutic benefits to prevent or treat lung metastasis. (C) 2015 AACR C1 [Zaynagetdinov, Rinat; Sherrill, Taylor P.; Gleaves, Linda A.; Habermann, Arun C.; Peebles, R. Stokes, Jr.; Blackwell, Timothy S.] Vanderbilt Univ, Dept Med, Dept Med Pulm & Crit Care Med, Div Allergy, Nashville, TN 37232 USA. [McLoed, Allyson G.; Saxon, Jamie A.; Fingleton, Barbara; Yull, Fiona E.; Blackwell, Timothy S.] Vanderbilt Univ, Dept Canc Biol, Nashville, TN 37232 USA. [Connelly, Linda] Univ Hawaii, Dept Pharmaceut Sci, Hilo, HI 96720 USA. [Dulek, Daniel] Vanderbilt Univ, Dept Pediat, Nashville, TN 37232 USA. [Peebles, R. Stokes, Jr.; Blackwell, Timothy S.] US Dept Vet Affairs, Nashville, TN USA. [Yull, Fiona E.; Blackwell, Timothy S.] Vanderbilt Univ, Med Ctr, Vanderbilt Ingram Canc Ctr, Nashville, TN 37232 USA. [Stathopoulos, Georgios T.] Univ Patras, Dept Physiol, Lab Mol Resp Carcinogenesis, Rion, Greece. [Blackwell, Timothy S.] Vanderbilt Univ, Dept Cell & Dev Biol, Nashville, TN 37232 USA. RP Zaynagetdinov, R (reprint author), Vanderbilt Univ, Sch Med, 1161 21st Ave South,T-1218 MCN, Nashville, TN 37232 USA. EM rinat.z.zaynagetdinov@vanderbilt.edu FU Cancer Initiative of North Carolina; NIH [T32HL094296]; European Research Council Starting Independent Investigator Grant [FP7-IDEAS-ERC-StG-2010-260524-KRASHIMPE]; Department of Veterans Affairs; Vanderbilt-Ingram Cancer Center Spore Grant FX This work was supported by a grant from the Lung Cancer Initiative of North Carolina and Free to Breathe (R. Zaynagetdinov), NIH grant T32HL094296 (R. Zaynagetdinov), European Research Council Starting Independent Investigator Grant FP7-IDEAS-ERC-StG-2010-260524-KRASHIMPE (G.T. Stathopoulos), the Department of Veterans Affairs (T.S. Blackwell), and by a Vanderbilt-Ingram Cancer Center Spore Grant 2010 (T.S. Blackwell). NR 49 TC 8 Z9 8 U1 1 U2 6 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD APR 15 PY 2015 VL 75 IS 8 BP 1624 EP 1634 DI 10.1158/0008-5472.CAN-14-2379 PG 11 WC Oncology SC Oncology GA CF9PH UT WOS:000352896900009 PM 25691457 ER PT J AU Perez, SE He, B Nadeem, M Wuu, J Scheff, SW Abrahamson, EE Ikonomovic, MD Mufson, EJ AF Perez, Sylvia E. He, Bin Nadeem, Muhammad Wuu, Joanne Scheff, Stephen W. Abrahamson, Eric E. Ikonomovic, Milos D. Mufson, Elliott J. TI Resilience of Precuneus Neurotrophic Signaling Pathways Despite Amyloid Pathology in Prodromal Alzheimer's Disease SO BIOLOGICAL PSYCHIATRY LA English DT Article DE Alzheimer's disease; Amyloid; Mild cognitive impairment; Neuropathology; Neurotrophic factors; Tau ID MILD COGNITIVE IMPAIRMENT; NERVE GROWTH-FACTOR; CHOLINERGIC BASAL FOREBRAIN; TRANSGENIC MOUSE; DEFAULT NETWORK; TAU PATHOLOGY; OLDER PERSONS; EARLY-ONSET; IN-VITRO; PRO-NGF AB BACKGROUND: Reduction of precuneus choline acetyltransferase activity co-occurs with greater beta-amyloid (A beta) in Alzheimer's disease (AD). Whether this cholinergic deficit is associated with alteration in nerve growth factor (NGF) signaling and its relation to A beta plaque and neurofibrillary tangle (NFT) pathology during disease onset is unknown. METHODS: Precuneus NGF upstream and downstream signaling levels relative to A beta and NFT pathology were evaluated using biochemistry and histochemistry in 62 subjects with a premortem diagnosis of non-cognitively impaired (NCI; n = 23), mild cognitive impairment (MCI; n = 21), and mild to moderate AD (n = 18). RESULTS: Immunoblots revealed increased levels of proNGF in AD subjects but not MCI subjects, whereas cognate receptors were unchanged. There were no significant differences in protein level for the downstream survival kinasesignaling proteins Erk and phospho-Erk among groups. Apoptotic phospho-JNK, phospho-JNK/JNK ratio, and Bcl-2 were significantly elevated in AD subjects. Soluble A beta(1-42) and fibrillar A beta measured by [H-3] Pittsburgh compound-B ([H-3] PiB) binding were significantly higher in AD subjects compared with MCI and NCI subjects. The density of plaques showed a trend to increase, but only 6-CN-PiB-positive plaques reached significance in AD subjects. AT8-positive, TOC-1-positive, and Tau C3-positive NFT densities were unchanged, whereas only AT8-positive neuropil thread density was statistically higher in AD subjects. A negative correlation was found between proNGF, phospho-JNK, and Bcl-2 levels and phospho-JNK/JNK ratio and cognition, whereas proNGF correlated positively with 6-CNPiB-positive plaques during disease progression. CONCLUSIONS: Data indicate that precuneus neurotrophin pathways are resilient to amyloid toxicity during the onset of AD. C1 [Perez, Sylvia E.; He, Bin; Nadeem, Muhammad; Mufson, Elliott J.] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA. [Wuu, Joanne] Univ Miami, Miller Sch Med, Dept Neurol, Miami, FL 33136 USA. [Scheff, Stephen W.] Univ Kentucky, Coll Med, Sanders Brown Ctr Aging, Lexington, KY 40536 USA. [Abrahamson, Eric E.; Ikonomovic, Milos D.] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15260 USA. [Abrahamson, Eric E.; Ikonomovic, Milos D.] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA. [Abrahamson, Eric E.; Ikonomovic, Milos D.] VA Pittsburgh Healthcare Syst, Geriatr Res Ctr, Pittsburgh, PA USA. RP Mufson, EJ (reprint author), Rush Univ, Med Ctr, Dept Neurol Sci, 1735 W Harrison St,Suite 310, Chicago, IL 60612 USA. EM emufson@rush.edu FU National Institute on Aging [PO1AG14449, PO1AG9466, P30AG10161, RO1AG025204, RO1AG043375] FX We thank the nuns, priests, and brothers from across the country that participated in the Rush Religious Order Study and the staff of the Rush Alzheimer's Disease Center. We also thank patients and research participants at the University of Kentucky Alzheimer's Disease Center. This study was supported by National Institute on Aging Grant Nos. PO1AG14449, PO1AG9466, P30AG10161, RO1AG025204, and RO1AG043375. NR 72 TC 13 Z9 13 U1 0 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0006-3223 EI 1873-2402 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD APR 15 PY 2015 VL 77 IS 8 BP 693 EP 703 DI 10.1016/j.biopsych.2013.12.016 PG 11 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA CE8LB UT WOS:000352092700007 PM 24529280 ER PT J AU Long, JA Watts, LT Chemello, J Huang, SL Shen, Q Duong, TQ AF Long, Justin Alexander Watts, Lora Talley Chemello, Jonathan Huang, Shiliang Shen, Qiang Duong, Timothy Q. TI Multiparametric and Longitudinal MRI Characterization of Mild Traumatic Brain Injury in Rats SO JOURNAL OF NEUROTRAUMA LA English DT Article DE behavioral assessments; diffusion tensor imaging; immunohistochemistry; TBI; controlled cortical impact; quantitative magnetic resonance imaging ID DIFFUSE AXONAL INJURY; CEREBRAL-BLOOD-FLOW; IMAGING FINDINGS; NEURONAL DEGENERATION; FLUORO-JADE; PERFUSION; EDEMA; DYNAMICS; HYPOXIA; MODELS AB This study reports T-2 and diffusion-tensor magnetic resonance imaging (MRI) studies of a mild open-skull, controlled cortical impact injury in rats (n=6) from 3 h to up to 14 d after traumatic brain injury (TBI). Comparison was made with longitudinal behavioral measurements and end-point histology. The impact was applied over the left primary forelimb somatosensory cortex (S1FL). The major findings were: 1) In the S1FL, T-2 increased and fractional anisotropy (FA) decreased at 3 h after TBI and gradually returned toward normal by Day 14; 2) in the S1FL, the apparent diffusion coefficient (ADC) increased at 3 h, peaked on Day 2, and gradually returned toward normal at Day 14; 3) in the corpus callosum underneath the S1FL, FA decreased at 3 h to Day 2 but returned to normal at Day 7 and 14, whereas T-2 and ADC were normal throughout; 4) heterogeneous hyperintense and hypointense T-2 map intensities likely indicated the presence of hemorrhage but were not independently verified; 5) lesion volumes defined by abnormal T-2, ADC, and FA showed similar temporal patterns, peaking around Day 2 and returning toward normal on Day 14; 6) the temporal profiles of lesion volumes were consistent with behavioral scores assessed by forelimb placement and forelimb foot fault tests; and 7) at 14 d post-TBI, there was substantial tissue recovery by MRI, which could either reflect true tissue recovery or reabsorption of edema. Histology performed 14 d post-TBI, however, showed a small cavitation and significant neuronal degeneration surrounding the cavitation in S1FL. Thus, the observed improvement of behavioral scores likely involves both functional recovery and functional compensation. C1 [Long, Justin Alexander; Watts, Lora Talley; Chemello, Jonathan; Huang, Shiliang; Shen, Qiang; Duong, Timothy Q.] Univ Texas Hlth Sci Ctr San Antonio, Res Imaging Inst, San Antonio, TX 78229 USA. [Watts, Lora Talley] Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol, San Antonio, TX 78229 USA. [Watts, Lora Talley; Duong, Timothy Q.] Univ Texas Hlth Sci Ctr San Antonio, Dept Neurol, San Antonio, TX 78229 USA. [Duong, Timothy Q.] Univ Texas Hlth Sci Ctr San Antonio, Dept Ophthalmol, San Antonio, TX 78229 USA. [Duong, Timothy Q.] South Texas Vet Hlth Care Syst, San Antonio, TX USA. RP Duong, TQ (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Res Imaging Inst, Dept Ophthamol, Radiol, 8403 Floyd Curl Dr, San Antonio, TX 78229 USA. EM duongt@uthscsa.edu RI Shen, Qiang/B-8784-2008 OI Shen, Qiang/0000-0002-4287-3403 FU NIH/NINDS [R01 NS45879]; TL1 grant; Clinical Translational Science Awards (CTSA) [KL2 TR001118, UL1TR000149, TL1TR001119] FX The authors wish to thank Timothy Schallert and Theresa Jones of UT Austin for their assistance in the setup of the behavioral assays utilized in this study. This work was supported in part by NIH/NINDS R01 NS45879 (TQD), a TL1 grant (JAL) and KL2 TR001118 (LTW) via the Clinical Translational Science Awards (CTSA, parent grant UL1TR000149 and TL1TR001119). Images were generated in the Core Optical Imaging Facility which is supported by UTHSCSA, NIH/NCI P30CA54174 and NIH/NIA P01AG19316. NR 40 TC 14 Z9 14 U1 0 U2 4 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD APR 15 PY 2015 VL 32 IS 8 BP 598 EP 607 DI 10.1089/neu.2014.3563 PG 10 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA CF2BS UT WOS:000352352900010 PM 25203249 ER PT J AU Goldkorn, A Ely, B Tangen, CM Tai, YC Xu, T Li, HL Twardowski, P Van Veldhuizen, PJ Agarwal, N Carducci, MA Monk, JP Garzotto, M Mack, PC Lara, P Higano, CS Hussain, M Vogelzang, NJ Thompson, IM Cote, RJ Quinn, DI AF Goldkorn, Amir Ely, Benjamin Tangen, Catherine M. Tai, Yu-Chong Xu, Tong Li, Hongli Twardowski, Przemyslaw Van Veldhuizen, Peter J. Agarwal, Neeraj Carducci, Michael A. Monk, J. Paul, III Garzotto, Mark Mack, Philip C. Lara, Primo, Jr. Higano, Celestia S. Hussain, Maha Vogelzang, Nicholas J. Thompson, Ian M., Jr. Cote, Richard J. Quinn, David I. TI Circulating tumor cell telomerase activity as a prognostic marker for overall survival in SWOG 0421: A phase III metastatic castration resistant prostate cancer trial SO INTERNATIONAL JOURNAL OF CANCER LA English DT Article DE circulating tumor cells; telomerase activity; prostate cancer; prognosis; biomarker ID PREDICTIVE BIOMARKER; DOCETAXEL; PLACEBO; MICROFILTER; ATRASENTAN; S0421; MEN AB Circulating tumor cells (CTC) are promising biomarkers in metastatic castration resistant prostate cancer (mCRPC), and telomerase activity (TA) is a recognized cancer marker. Therefore, we hypothesized that CTC TA may be prognostic of overall survival (OS) in mCRPC. To test this, we used a novel Parylene-C slot microfilter to measure live CTC TA in S0421, a phase III SWOG-led therapeutic trial. Blood samples underwent CTC capture and TA measurement by microfilter, as well as parallel enumeration by CellSearch (Janssen/J&J). Cox regression was used to assess baseline (pre-treatment) TA versus OS, and recursive partitioning was used to explore potential prognostic subgroups and to generate Kaplan-Meier (KM) OS curves. Samples were obtained from 263 patients and generated 215 TA measures. In patients with baseline CTC count 5 (47% of patients), higher CTC TA was associated with hazard ratio 1.14 (p=0.001) for OS after adjusting for other clinical covariates including CTC counts and serum PSA at study entry. Recursive partitioning identified new candidate risk groups with KM OS curve separation based on CTC counts and TA. Notably, in men with an intermediate range baseline CTC count (6-54 CTCs/7.5 ml), low versus high CTC TA was associated with median survival of 19 versus 12 months, respectively (p=0.009). Baseline telomerase activity from CTCs live-captured on a new slot microfilter is the first CTC-derived candidate biomarker prognostic of OS in a large patient subgroup in a prospective clinical trial. CTC telomerase activity thus merits further study and validation as a step towards molecular CTC-based precision cancer management. C1 [Goldkorn, Amir; Xu, Tong; Quinn, David I.] Univ So Calif, Keck Sch Med, Div Med Oncol, Dept Med, Los Angeles, CA 90033 USA. [Goldkorn, Amir; Xu, Tong; Quinn, David I.] Norris Comprehens Canc Ctr, Los Angeles, CA USA. [Ely, Benjamin; Tangen, Catherine M.; Li, Hongli] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, SWOG Stat Ctr, Seattle, WA 98104 USA. [Tai, Yu-Chong] CALTECH, Pasadena, CA 91125 USA. [Twardowski, Przemyslaw] City Hope Natl Med Ctr, Dept Med Oncol & Therapeut Res, Duarte, CA USA. [Van Veldhuizen, Peter J.] Univ Kansas, Ctr Canc, Hem Onc Div, Westwood, KS USA. [Agarwal, Neeraj] Univ Utah, Huntsman Canc Inst, Div Oncol, Salt Lake City, UT USA. [Carducci, Michael A.] Johns Hopkins Univ, Dept Urol, Baltimore ECOG, Baltimore, MD USA. [Carducci, Michael A.] Johns Hopkins Univ, Dept Oncol, Baltimore ECOG, Baltimore, MD USA. [Monk, J. Paul, III] Ohio State Univ, CALGB, Div Med Oncol, Columbus, OH 43210 USA. [Garzotto, Mark] Portland VA Med Ctr, Dept Urol, Portland, OR USA. [Mack, Philip C.; Lara, Primo, Jr.] Univ Calif Davis, Div Hematol & Oncol, Sacramento, CA 95817 USA. [Higano, Celestia S.] Univ Washington, Seattle Canc Care Alliance, Puget Sound Oncol Consortium, Div Oncol,Dept Med,Dept Urol, Seattle, WA 98195 USA. [Hussain, Maha] Univ Michigan, Ctr Comprehens Canc, Div Hematol Oncol, Ann Arbor, MI 48109 USA. [Vogelzang, Nicholas J.] Comprehens Canc Ctr Nevada, Div Med Oncol, Las Vegas, NV USA. [Vogelzang, Nicholas J.] US Oncol Res, Las Vegas, NV USA. [Thompson, Ian M., Jr.] Univ Texas Hlth Sci Ctr San Antonio, Dept Urol, San Antonio, TX 78229 USA. [Cote, Richard J.] Univ Miami, Miller Sch Med, Dept Pathol, Miami, FL 33136 USA. RP Goldkorn, A (reprint author), Univ So Calif, Keck Sch Med, Div Med Oncol, Dept Internal Med, Los Angeles, CA 90033 USA. EM agoldkor@med.usc.edu RI Quinn, David/F-4343-2015 OI Quinn, David/0000-0002-1411-0417 FU National Cancer Institute at the National Institutes of Health; DHHS [CA32102, CA38926, CA46368, CA46441, CA58882, CA58861, CA12644, CA22433]; DHHS. [CA46282, CA27057, CA58416, CA45807, CA45808, CA45450, CA42777, CA35281, CA20319, CA35090, CA76429, CA14028, CA67575, CA45377, CA68183, CA63848, CA74647, CA16385, CA35192, CA63844]; DHHS; [CA68183, CA11083, CA63845, CA76447, CA35128, CA13612, CA35431, CA76448, CA35178, CA35176, CA35119, CA35421, CA128567, CA04919, CA45560, CA37981, CA58723, CA21115, CA31946, CA16116, CA31949, CA014089-38, CCSRI 015469, CA141077] FX Grant sponsors: PHS Cooperative Agreement grants by the National Cancer Institute at the National Institutes of Health and DHHS; Grant numbers: CA32102, CA38926, CA46368, CA46441, CA58882, CA58861, CA12644, CA22433, CA46282, CA27057, CA58416, CA45807, CA45808, CA45450, CA42777, CA35281, CA20319, CA35090, CA76429, CA14028, CA67575, CA45377, CA68183, CA63848, CA74647, CA16385, CA35192, CA63844, CA11083, CA63845, CA76447, CA35128, CA13612, CA35431, CA76448, CA35178, CA35176, CA35119, CA35421, CA128567, CA04919, CA68183, CA45560, CA37981, CA58723, CA21115, CA31946, CA16116, CA31949, CA014089-38, CCSRI 015469 and CA141077; Grant sponsors: Hope Foundation and Abbott Laboratories and Sanofi-Aventis NR 27 TC 10 Z9 11 U1 0 U2 12 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0020-7136 EI 1097-0215 J9 INT J CANCER JI Int. J. Cancer PD APR 15 PY 2015 VL 136 IS 8 BP 1856 EP 1862 DI 10.1002/ijc.29212 PG 7 WC Oncology SC Oncology GA CB4SS UT WOS:000349619000011 PM 25219358 ER PT J AU Shore, S Ho, PM Lambert-Kerzner, A Glorioso, TJ Carey, EP Cunningham, F Longo, L JackeviciusPharmD, C Rose, A Turakhia, MP AF Shore, Supriya Ho, P. Michael Lambert-Kerzner, Anne Glorioso, Thomas J. Carey, Evan P. Cunningham, Fran Longo, Lisa Jackevicius, Cynthia Rose, Adam Turakhia, Mintu P. TI Site-Level Variation in and Practices Associated With Dabigatran Adherence SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID ATRIAL-FIBRILLATION; MEDICATION ADHERENCE; MYOCARDIAL-INFARCTION; STROKE PREVENTION; PHARMACY RECORDS; PATIENT-OUTCOMES; TREAT-AF; HEALTH; ANTICOAGULATION; WARFARIN AB IMPORTANCE Unlike warfarin, which requires routine laboratory testing and dose adjustment, target-specific oral anticoagulants like dabigatran do not. However, optimal follow-up infrastructure and modifiable site-level factors associated with improved adherence to dabigatran are unknown. OBJECTIVES To assess site-level variation in dabigatran adherence and to identify site-level practices associated with higher dabigatran adherence. DESIGN, SETTING, AND PARTICIPANTS Mixed-methods study involving retrospective quantitative and cross-sectional qualitative data. A total of 67 Veterans Health Administration sites with 20 or more patients filling dabigatran prescriptions between 2010 and 2012 for nonvalvular atrial fibrillation were sampled (4863 total patients; median, 51 patients per site). Forty-seven pharmacists from 41 eligible sites participated in the qualitative inquiry. EXPOSURE Site-level practices identified included appropriate patient selection, pharmacist-driven patient education, and pharmacist-led adverse event and adherence monitoring. MAIN OUTCOMES AND MEASURES Dabigatran adherence (intensity of drug use during therapy) defined by proportion of days covered (ratio of days supplied by prescription to follow-up duration) of 80% or more. RESULTS The median proportion of patients adherent to dabigatran was 74% (interquartile range [IQR], 66%-80%). After multivariable adjustment, dabigatran adherence across sites varied by a median odds ratio of 1.57. Review of practices across participating sites showed that appropriate patient selection was performed at 31 sites, pharmacist-led education was provided at 30 sites, and pharmacist-led monitoring at 28 sites. The proportion of adherent patients was higher at sites performing appropriate selection (75% vs 69%), education (76% vs 66%), and monitoring (77% vs 65%). Following multivariable adjustment, association between pharmacist-led education and dabigatran adherence was not statistically significant (relative risk [RR], 0.94; 95% Cl, 0.83-1.06). Appropriate patient selection (RR, 1.14; 95% Cl, 1.05-1.25), and provision of pharmacist-led monitoring (RR, 1.25; 95% Cl, 1.11-1.40 were associated with better patient adherence. Additionally, longer duration of monitoring and providing more intensive care to nonadherent patients in collaboration with the clinician improved adherence. CONCLUSIONS AND RELEVANCE Among nonvalvular atrial fibrillation patients treated with dabigatran, there was variability in patient medication adherence across Veterans Health Administration sites. Specific pharmacist-based activities were associated with greater patient adherence to dabigatran. C1 [Shore, Supriya] Emory Univ, Sch Med, Atlanta, GA USA. [Ho, P. Michael; Lambert-Kerzner, Anne; Glorioso, Thomas J.; Carey, Evan P.] Vet Affairs Eastern Colorado Hlth Care Syst, Denver, CO USA. [Ho, P. Michael; Glorioso, Thomas J.; Carey, Evan P.] Univ Colorado, Aurora, CO USA. [Ho, P. Michael; Lambert-Kerzner, Anne; Glorioso, Thomas J.; Carey, Evan P.] Colorado Cardiovasc Outcomes Res Consortium, Denver, CO USA. [Cunningham, Fran; Longo, Lisa] Pharm Benefits Management Serv, Vet Affairs, Hines, IL USA. [Cunningham, Fran; Longo, Lisa] Ctr Medicat Safety, Hines, IL USA. [Jackevicius, Cynthia] Vet Affairs Greater Los Angeles Hlth Care Syst, Los Angeles, CA USA. [Jackevicius, Cynthia] Western Univ Hlth Sci, Pomona, CA USA. [Rose, Adam] Bedford Veterabs Affairs Med Ctr, Bedford, MA USA. [Rose, Adam] Boston Univ, Boston, MA 02215 USA. [Turakhia, Mintu P.] Vet Affairs Palo Alto Hlth Care Syst, Palo Alto, CA USA. [Turakhia, Mintu P.] Stanford Univ, Sch Med, Stanford, CA 94305 USA. RP Turakhia, MP (reprint author), VA Palo Alto Hlth Care Syst, Dept Cardiol, 3801 Miranda Ave,Ste 111C, Palo Alto, CA 94304 USA. EM mintu@stanford.edu FU Career Development Award from VA Health Services Research Development; American Heart Association National Scientist Development Grant; Gilead Sciences Cardiovascular Research Scholars Program award FX Dr Turakhia is supported by a Career Development Award from VA Health Services Research & Development, an American Heart Association National Scientist Development Grant, and a Gilead Sciences Cardiovascular Research Scholars Program award. NR 24 TC 27 Z9 27 U1 0 U2 5 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD APR 14 PY 2015 VL 313 IS 14 BP 1443 EP 1450 DI 10.1001/jama.2015.2761 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA CF8OK UT WOS:000352821200020 PM 25871670 ER PT J AU Sheridan, CM Grogan, TR Nguyen, HG Galet, C Rettig, MB Hsieh, AC Ruggero, D AF Sheridan, Christine Moore Grogan, Tristan R. Nguyen, Hao G. Galet, Colette Rettig, Matthew B. Hsieh, Andrew C. Ruggero, Davide TI YB-1 and MTA1 protein levels and not DNA or mRNA alterations predict for prostate cancer recurrence SO ONCOTARGET LA English DT Article DE translation control; prostate cancer; PSA recurrence; biomarker; YB-1 ID RADICAL PROSTATECTOMY AB Attempts to identify biomarkers to detect prostate tumorigenesis, and thus minimize prostate cancer progression and inform treatment decisions have primarily focused on alterations at the DNA and mRNA levels, ignoring alterations at the level of protein synthesis control. We have previously shown that the PI3K-AKT-mTOR pathway, frequently deregulated in prostate cancer, specifically induces the synthesis of proteins that contribute to metastasis, most notably YB-1 and MTA1, without altering mRNA levels thereby demonstrating the importance of translation control in driving the expression of these genes in cancer. Here, we analyze genomic sequencing and mRNA expression databases, as well as protein expression employing an annotated tissue microarray generated from 332 prostate cancer patients with 15 years of clinical follow-up to determine the combined prognostic capability of YB-1 and MTA1 alterations in forecasting prostate cancer outcomes. Remarkably, protein abundance, but not genomic or transcriptional alterations of YB-1 and MTA1, is predictive of disease recurrence, exhibiting a dose-dependent effect on time to PSA recurrence, an indicator of tumor relapse. Moreover, high protein levels of YB-1 and MTA1 are associated with a 3-fold increased risk for requiring future hormone therapy or radiation therapy. Importantly, YB-1 and MTA1 protein levels significantly increase the predictive capacity of a clinical model for prostate cancer recurrence. These findings demonstrate that protein abundance of YB-1 and MTA1, irrespective of DNA or mRNA status, can predict for prostate cancer relapse and uncover a vast underappreciated repository of biomarkers regulated at the level of protein expression. C1 [Sheridan, Christine Moore; Nguyen, Hao G.; Hsieh, Andrew C.; Ruggero, Davide] Univ Calif San Francisco, Dept Urol, San Francisco, CA USA. [Grogan, Tristan R.] Univ Calif Los Angeles, David Geffen Sch Med, Stat Core, Los Angeles, CA 90095 USA. [Galet, Colette; Rettig, Matthew B.] VA Greater Los Angeles Healthcare Syst West Los A, Dept Med, Los Angeles, CA 90073 USA. [Rettig, Matthew B.] Univ Calif Los Angeles, Sch Med, Dept Urol, Los Angeles, CA USA. [Hsieh, Andrew C.] Univ Calif San Francisco, Dept Med, Div Hematol Oncol, San Francisco, CA USA. RP Rettig, MB (reprint author), VA Greater Los Angeles Healthcare Syst West Los A, Dept Med, Los Angeles, CA 90073 USA. EM mrettig@mednet.ucla.edu; ahsieh@fredhutch.org; davide.ruggero@ucsf.edu FU Goldberg-Benioff Program in Cancer Translational Biology FX We thank the members of the Ruggero laboratory for critical discussion and support. We thank the Goldberg-Benioff Program in Cancer Translational Biology for their support and commitment to prostate cancer research. We thank Justin Pak (Keyence Corporation of America), DeLaine Larsen (UCSF, Nikon Imaging Center), and Kurt Thorn (UCSF, Nikon Imaging Center) for providing technical support for imaging. We thank Jennifer M. Shen and Christine Milentis for assistance with editing the manuscript. NR 18 TC 4 Z9 4 U1 0 U2 1 PU IMPACT JOURNALS LLC PI ALBANY PA 6211 TIPTON HOUSE, STE 6, ALBANY, NY 12203 USA SN 1949-2553 J9 ONCOTARGET JI Oncotarget PD APR 10 PY 2015 VL 6 IS 10 BP 7470 EP 7480 PG 11 WC Oncology; Cell Biology SC Oncology; Cell Biology GA CI6QJ UT WOS:000354885300009 PM 25797255 ER PT J AU Wang, JY Xia, JC Zhang, F Shi, YJ Wu, Y Pu, HJ Liou, AKF Leak, RK Yu, XG Chen, L Chen, J AF Wang, Jiayin Xia, Jinchao Zhang, Feng Shi, Yejie Wu, Yun Pu, Hongjian Liou, Anthony K. F. Leak, Rehana K. Yu, Xinguang Chen, Ling Chen, Jun TI Galectin-1-secreting neural stem cells elicit long-term neuroprotection against ischemic brain injury SO SCIENTIFIC REPORTS LA English DT Article ID PROMOTES AXONAL REGENERATION; MICROGLIA/MACROPHAGE POLARIZATION DYNAMICS; FOCAL CEREBRAL-ISCHEMIA; WHITE-MATTER INJURY; SPINAL-CORD-INJURY; OXIDIZED GALECTIN-1; FUNCTIONAL RECOVERY; PERIPHERAL-NERVES; REGULATES NEUROGENESIS; STEM/PROGENITOR CELLS AB Galectin-1 (gal-1), a special lectin with high affinity to beta-galactosides, is implicated in protection against ischemic brain injury. The present study investigated transplantation of gal-1-secreting neural stem cell (s-NSC) into ischemic brains and identified the mechanisms underlying protection. To accomplish this goal, secretory gal-1 was stably overexpressed in NE-4C neural stem cells. Transient cerebral ischemia was induced in mice by middle cerebral artery occlusion for 60 minutes and s-NSCs were injected into the striatum and cortex within 2 hours post-ischemia. Brain infarct volume and neurological performance were assessed up to 28 days post-ischemia. s-NSC transplantation reduced infarct volume, improved sensorimotor and cognitive functions, and provided more robust neuroprotection than non-engineered NSCs or gal-1-overexpressing (but non-secreting) NSCs. White matter injury was also ameliorated in s-NSC-treated stroke mice. Gal-1 modulated microglial function in vitro, by attenuating secretion of pro-inflammatory cytokines (TNF-alpha and nitric oxide) in response to LPS stimulation and enhancing production of anti-inflammatory cytokines (IL-10 and TGF-beta). Gal-1 also shifted microglia/macrophage polarization toward the beneficial M2 phenotype in vivo by reducing CD16 expression and increasing CD206 expression. In sum, s-NSC transplantation confers robust neuroprotection against cerebral ischemia, probably by alleviating white matter injury and modulating microglial/macrophage function. C1 [Wang, Jiayin; Wu, Yun] Capital Med Univ, Xuanwu Hosp, Cell Therapy Ctr, Beijing 100053, Peoples R China. [Xia, Jinchao] Zhengzhou Univ, Henan Prov Peoples Hosp, Cerebrovasc Ctr, Zhengzhou 450003, Peoples R China. [Wang, Jiayin; Xia, Jinchao; Zhang, Feng; Shi, Yejie; Wu, Yun; Pu, Hongjian; Liou, Anthony K. F.; Chen, Jun] Univ Pittsburgh, Sch Med, Ctr Cerebrovasc Dis Res, Pittsburgh, PA 15213 USA. [Leak, Rehana K.] Duquesne Univ, Mylan Sch Pharm, Div Pharmaceut Sci, Pittsburgh, PA 15282 USA. [Yu, Xinguang; Chen, Ling] Chinese Peoples Liberat Army Gen Hosp, Dept Neurosurg & PLA Inst Neurosurg, Beijing 100853, Peoples R China. [Zhang, Feng; Shi, Yejie; Pu, Hongjian; Chen, Jun] Vet Affairs Pittsburgh Hlth Care Syst, Geriatr Res Educ & Clin Ctr, Pittsburgh, PA 15261 USA. RP Chen, J (reprint author), Univ Pittsburgh, Sch Med, Ctr Cerebrovasc Dis Res, Pittsburgh, PA 15213 USA. EM chlyz34@163.com; chenj2@upmc.edu OI Leak, Rehana/0000-0003-2817-7417; Shi, Yejie/0000-0001-7502-9201 FU U.S. National Institutes of Health [NS036736, NS045048, NS089534]; U.S. Department of Veterans Affairs; High Level Talent Fund of the Beijing Healthcare System [2011-3-093]; Program for New Century Excellent Talents in University [NCET-12-0612]; National Natural Science Foundation of China [81301066]; Beijing Nova Program [2013019]; RRD Merit Review FX J.W. and J.X. contributed equally to the work. This project was supported by U.S. National Institutes of Health grants NS036736, NS045048, and NS089534 (to J.C.), U.S. Department of Veterans Affairs Research Career Scientist Award and RR&D Merit Review (to J.C.). L.C. was supported by the High Level Talent Fund of the Beijing Healthcare System (Grant No. 2011-3-093) and the Program for New Century Excellent Talents in University (Grant No. NCET-12-0612). J.W. was supported by the National Natural Science Foundation of China (Grant No. 81301066) and Beijing Nova Program (Grant No. 2013019). The authors are indebted to Carol Culver for excellent editorial assistance and Pat Strickler for excellent administrative support. NR 62 TC 8 Z9 10 U1 3 U2 24 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD APR 10 PY 2015 VL 5 AR 9621 DI 10.1038/srep09621 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CF6AM UT WOS:000352638800001 PM 25858671 ER PT J AU Wang, XW Wei, L Cramer, JM Leibowitz, BJ Judge, C Epperly, M Greenberger, J Wang, FC Li, LH Stelzner, MG Dunn, JCY Martin, MG Lagasse, E Zhang, L Yu, J AF Wang, Xinwei Wei, Liang Cramer, Julie M. Leibowitz, Brian J. Judge, Colleen Epperly, Michael Greenberger, Joel Wang, Fengchao Li, Linheng Stelzner, Matthias G. Dunn, James C. Y. Martin, Martin G. Lagasse, Eric Zhang, Lin Yu, Jian TI Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation SO SCIENTIFIC REPORTS LA English DT Article ID COLORECTAL-CANCER CELLS; GASTROINTESTINAL-SYNDROME; CRANIAL IRRADIATION; HEMATOPOIETIC STEM; IN-VITRO; P53; PUMA; INDUCTION; DAMAGE; LGR5 AB Exposure to high levels of ionizing radiation (IR) leads to debilitating and dose-limiting gastrointestinal (GI) toxicity. Using three-dimensional mouse crypt culture, we demonstrated that p53 target PUMA mediates radiation-induced apoptosis via a cell-intrinsic mechanism, and identified the GSK-3 inhibitor CHIR99021 as a potent radioprotector. CHIR99021 treatment improved Lgr51 cell survival and crypt regeneration after radiation in culture and mice. CHIR99021 treatment specifically blocked apoptosis and PUMAinduction and K120 acetylation of p53 mediated by acetyl-transferase Tip60, while it had no effect on p53 stabilization, phosphorylation or p21 induction. CHIR99021 also protected human intestinal cultures from radiation by PUMA but not p21 suppression. These results demonstrate that p53 posttranslational modifications play a key role in the pathological and apoptotic response of the intestinal stem cells to radiation and can be targeted pharmacologically. C1 [Wang, Xinwei; Wei, Liang; Cramer, Julie M.; Leibowitz, Brian J.; Judge, Colleen; Lagasse, Eric; Yu, Jian] Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA 15213 USA. [Wang, Xinwei; Wei, Liang; Leibowitz, Brian J.; Judge, Colleen; Epperly, Michael; Greenberger, Joel; Zhang, Lin; Yu, Jian] Univ Pittsburgh, Inst Canc, Pittsburgh, PA 15213 USA. [Epperly, Michael; Greenberger, Joel; Yu, Jian] Univ Pittsburgh, Sch Med, Dept Radiat Oncol, Pittsburgh, PA 15213 USA. [Wang, Fengchao; Li, Linheng] Univ Kansas, Med Ctr, Stowers Inst Med Res, Dept Pathol, Kansas City, MS 64110 USA. [Stelzner, Matthias G.] Vet Affairs Greater Los Angeles Healthcare Syst, Dept Surg, Los Angeles, CA 90073 USA. [Dunn, James C. Y.; Martin, Martin G.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Surg, Los Angeles, CA 90095 USA. [Dunn, James C. Y.; Martin, Martin G.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pediat, Los Angeles, CA 90095 USA. [Zhang, Lin] Univ Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15213 USA. RP Yu, J (reprint author), Univ Pittsburgh, Sch Med, Dept Pathol, 5117 Ctr Ave, Pittsburgh, PA 15213 USA. EM yuj2@upmc.edu OI Judge, Colleen/0000-0001-9167-9650 FU NIH [U01-DK085570, CA129829, CA106348]; American Cancer Society [RGS-10-124-01-CCE, U01-DK085535, U01DK085507]; NIDDK; NIAID [U01]; [5T32GM008208]; [P30CA047904] FX We thank members in the Yu and Zhang labs for helpful discussions. This work is supported in part by NIH grants U01-DK085570, NIH grant CA129829, American Cancer Society grant RGS-10-124-01-CCE (J Yu), U01-DK085535 (M Martin), U01DK085507 (L Li), and NIH grant CA106348 (L Zhang). Yu, Li and Martin laboratories are members of the Intestinal Stem Cell Consortium, supported in part by NIDDK and NIAID (U01). C.J. was supported by 5T32GM008208. This project used the UPCI shared glassware, animal, and cell and tissue imaging facilities that were supported in part by award P30CA047904. NR 48 TC 11 Z9 11 U1 0 U2 9 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD APR 10 PY 2015 VL 5 AR UNSP 8566 DI 10.1038/srep08566 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CF5ZX UT WOS:000352637300001 PM 25858503 ER PT J AU Gordon, AJ Jenkins, JA AF Gordon, Adam J. Jenkins, Jennifer A. TI The Time Is Now: The Role of Pharmacotherapies in Expanding Treatment for Opioid Use Disorder SO SUBSTANCE ABUSE LA English DT Editorial Material C1 [Gordon, Adam J.] Univ Pittsburgh, Sch Med, Div Gen Internal Med, Sect Treatment Res & Educ Addict Med, Pittsburgh, PA USA. [Gordon, Adam J.] VA Pittsburgh Healthcare Syst, Ctr Hlth Equ Res & Promot, Pittsburgh, PA 15240 USA. [Gordon, Adam J.] VA Pittsburgh Healthcare Syst, Mental Illness Res Educ & Clin Ctr, Pittsburgh, PA 15240 USA. [Jenkins, Jennifer A.] VA Puget Sound Hlth Care Syst, Ctr Innovat Vet Ctr & Value Driven Care, Seattle, WA USA. RP Gordon, AJ (reprint author), VA Pittsburgh Healthcare Syst, Ctr Hlth Equ Res & Promot, Univ Dr C,Bldg 30,Mailcode 151-C, Pittsburgh, PA 15240 USA. EM gordona@medschool.pitt.edu FU American Academy of Addiction Psychiatry (AAAP); Providers' Clinical Support System for Opioid Therapies from SAMHSA [5H79TI023439, 1H79TI025595] FX This special issue is supported by the American Academy of Addiction Psychiatry (AAAP). Funding for this initiative was made possible (in part) by Providers' Clinical Support System for Opioid Therapies (grant nos. 5H79TI023439 and 1H79TI025595) from SAMHSA. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services, nor does mention of trade names, commercial practices, or organizations imply endorsement by the US government. NR 12 TC 1 Z9 1 U1 1 U2 1 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0889-7077 EI 1547-0164 J9 SUBST ABUS JI Subst. Abus. PD APR 3 PY 2015 VL 36 IS 2 SI SI BP 127 EP 128 DI 10.1080/08897077.2015.1033884 PG 2 WC Substance Abuse SC Substance Abuse GA CK6UF UT WOS:000356363100001 PM 25826044 ER PT J AU Gordon, AJ Jenkins, JA Galanter, M AF Gordon, Adam J. Jenkins, Jennifer A. Galanter, Marc TI International Addiction Scholarship: Promise, Progress, and Results From the Annual Meeting of the International Society of Addiction Medicine SO SUBSTANCE ABUSE LA English DT Editorial Material ID BORDERS C1 [Gordon, Adam J.] Univ Pittsburgh, Sch Med, Div Gen Internal Med, Sect Treatment Res & Educ Addict Med, Pittsburgh, PA USA. [Gordon, Adam J.] VA Pittsburgh Healthcare Syst, Ctr Hlth Equ Res & Promot, Pittsburgh, PA 15240 USA. [Gordon, Adam J.] VA Pittsburgh Healthcare Syst, Mental Illness Res Educ & Clin Ctr, Pittsburgh, PA 15240 USA. [Jenkins, Jennifer A.] VA Puget Sound Hlth Care Syst, Ctr Innovat Vet Ctr & Value Driven Care, Seattle, WA USA. [Galanter, Marc] NYU, Sch Med, Div Alcoholism & Drug Abuse, New York, NY USA. RP Gordon, AJ (reprint author), VA Pittsburgh Healthcare Syst, Ctr Hlth Equ Res & Promot, Univ Dr C,Bldg 30,Mailcode 151-C, Pittsburgh, PA 15240 USA. EM gordona@medschool.pitt.edu NR 6 TC 1 Z9 1 U1 0 U2 0 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0889-7077 EI 1547-0164 J9 SUBST ABUS JI Subst. Abus. PD APR 3 PY 2015 VL 36 IS 2 SI SI BP 129 EP 130 DI 10.1080/08897077.2015.1033887 PG 2 WC Substance Abuse SC Substance Abuse GA CK6UF UT WOS:000356363100002 PM 25826272 ER PT J AU Jenkins, JA Alford, DP Gordon, AJ AF Jenkins, Jennifer A. Alford, Daniel P. Gordon, Adam J. TI Building Connections and Bridging Interdisciplinary Leadership in Addictions: 2014 AMERSA Annual Conference and a Thank You to Reviewers SO SUBSTANCE ABUSE LA English DT Editorial Material C1 [Jenkins, Jennifer A.] VA Puget Sound Hlth Care Syst, Ctr Innovat Vet Ctr & Value Driven Care, Seattle, WA USA. [Alford, Daniel P.] AMERSA, Cranston, RI USA. [Alford, Daniel P.] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA. [Gordon, Adam J.] Univ Pittsburgh, Sch Med, Div Gen Internal Med, Sect Treatment Res & Educ Addict Med, Pittsburgh, PA USA. [Gordon, Adam J.] VA Pittsburgh Healthcare Syst, Ctr Hlth Equ Res & Promot, Pittsburgh, PA 15240 USA. [Gordon, Adam J.] VA Pittsburgh Healthcare Syst, Mental Illness Res Educ & Clin Ctr, Pittsburgh, PA 15240 USA. RP Gordon, AJ (reprint author), VA Pittsburgh Healthcare Syst, Ctr Hlth Equ Res & Promot, Univ Dr C,Bldg 30,Mailcode 151-C, Pittsburgh, PA 15240 USA. EM gordona@medschool.pitt.edu NR 11 TC 1 Z9 1 U1 0 U2 0 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0889-7077 EI 1547-0164 J9 SUBST ABUS JI Subst. Abus. PD APR 3 PY 2015 VL 36 IS 2 SI SI BP 131 EP 134 DI 10.1080/08897077.2015.1033910 PG 4 WC Substance Abuse SC Substance Abuse GA CK6UF UT WOS:000356363100003 PM 25826178 ER PT J AU Cochran, G Woo, B Lo-Ciganic, WH Gordon, AJ Donohue, JM Gellad, WF AF Cochran, Gerald Woo, Bongki Lo-Ciganic, Wei-Hsuan Gordon, Adam J. Donohue, Julie M. Gellad, Walid F. TI Defining Nonmedical Use of Prescription Opioids Within Health Care Claims: A Systematic Review SO SUBSTANCE ABUSE LA English DT Review DE systematic review; Non-medical use of prescription opioids; health insurance ID NATIONAL EPIDEMIOLOGIC SURVEY; MENTAL-HEALTH; UNITED-STATES; 10-YEAR PERSPECTIVE; IDENTIFY PATIENTS; USE DISORDERS; DRUG-USE; ABUSE; MISUSE; PAIN AB Background: Health insurance claims data may play an important role for health care systems and payers in monitoring the nonmedical use of prescription opioids (NMPO) among patients. However, these systems require valid methods for identifying NMPO if they are to target individuals for intervention. Limited efforts have been made to define NMPO using administrative data available to health systems and payers. We conducted a systematic review of publications that defined and measured NMPO within health insurance claims databases in order to describe definitions of NMPO and identify areas for improvement. Methods: We searched 8 electronic databases for articles that included terms related to NMPO and health insurance claims. A total of 2613 articles were identified in our search. Titles, abstracts, and article full texts were assessed according to predetermined inclusion/exclusion criteria. Following article selection, we extracted general information, conceptual and operational definitions of NMPO, methods used to validate operational definitions of NMPO, and rates of NMPO. Results: A total of 7 studies met all inclusion criteria. A range of conceptual NMPO definitions emerged, from concrete concepts of abuse to qualified definitions of probable misuse. Operational definitions also varied, ranging from variables that rely on diagnostic codes to those that rely on opioid dosage and/or filling patterns. Quantitative validation of NMPO definitions was reported in 3 studies (e.g., receiver operating curves or logistic regression), with each study indicating adequate validity. Three studies reported qualitative validation, using face and content validity. One study reported no validation efforts. Rates of NMPO among the studies' populations ranged from 0.75% to 10.32%. Conclusions: Disparate definitions of NMPO emerged from the literature, with little uniformity in conceptualization and operationalization. Validation approaches were also limited, and rates of NMPO varied across studies. Future research should prospectively test and validate a construct of NMPO to disseminate to payers and health officials. C1 [Cochran, Gerald] Univ Pittsburgh, Sch Social Work, Pittsburgh, PA 15260 USA. [Cochran, Gerald; Lo-Ciganic, Wei-Hsuan; Gordon, Adam J.; Donohue, Julie M.; Gellad, Walid F.] Univ Pittsburgh, Ctr Pharmaceut Policy & Prescribing, Pittsburgh, PA 15260 USA. [Woo, Bongki] Boston Coll, Sch Social Work, Boston, MA USA. [Gordon, Adam J.; Gellad, Walid F.] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. [Gordon, Adam J.; Gellad, Walid F.] Univ Pittsburgh, Sch Med, Pittsburgh, PA 15260 USA. [Donohue, Julie M.] Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA 15260 USA. RP Cochran, G (reprint author), Univ Pittsburgh, Sch Social Work, 4200 Forbes Ave,2117 CL, Pittsburgh, PA 15260 USA. EM gcochran@pitt.edu OI Donohue, Julie/0000-0003-2418-6017 FU CDC/NIDA [U01CE002496-01]; VA HSR&D Career Development Award [09-207] FX Drs. Cochran, Donohue, Gordon, and Gellad are supported by CDC/NIDA U01CE002496-01. Dr. Gellad is also supported by a VA HSR&D Career Development Award (09-207). Funders were not involved in study design, the collection, analysis, or interpretation of data, the writing of the report, or the decision to submit the manuscript for publication. The authors declare that they have no conflicts of interest. NR 39 TC 6 Z9 6 U1 4 U2 9 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0889-7077 EI 1547-0164 J9 SUBST ABUS JI Subst. Abus. PD APR 3 PY 2015 VL 36 IS 2 SI SI BP 192 EP 202 DI 10.1080/08897077.2014.993491 PG 11 WC Substance Abuse SC Substance Abuse GA CK6UF UT WOS:000356363100015 PM 25671499 ER PT J AU Farmer, CM Lindsay, D Williams, J Ayers, A Schuster, J Cilia, A Flaherty, MT Mandell, T Gordon, AJ Stein, BD AF Farmer, Carrie M. Lindsay, Dawn Williams, Jessica Ayers, Amanda Schuster, James Cilia, Alyssa Flaherty, Michael T. Mandell, Todd Gordon, Adam J. Stein, Bradley D. TI Practice Guidance for Buprenorphine for the Treatment of Opioid Use Disorders: Results ofanExpert Panel Process SO SUBSTANCE ABUSE LA English DT Article DE Buprenorphine; opioid use disorders; clinical practice guidelines ID 1ST 3 YEARS; SERVICE UTILIZATION; ALGORITHM PROJECT; MENTAL-DISORDERS; UNITED-STATES; ADDICTION; BARRIERS; DEPENDENCE; IMPLEMENTABILITY; COMORBIDITY AB ABSTRACT. Background: Although the number of physicians credentialed to prescribe buprenorphine has increased over time, many credentialed physicians may be reluctant to treat individuals with opioid use disorders due to discomfort with prescribing buprenorphine. Although prescribing physicians are required to complete a training course, many have questions about buprenorphine and treatment guidelines have not been updated to reflect clinical experience in recent years. We report on an expert panel process to update and expand buprenorphine guidelines. Methods: We identified candidate guidelines through expert opinion and a review of the literature and used a modified RAND/UCLA Appropriateness Method to assess the validity of the candidate guidelines. An expert panel completed 2 rounds of rating, with a meeting to discuss the guidelines between the first and second ratings. Results: Through the rating process, expert panel members rated 90 candidate guideline statements across 8 domains, including candidacy for buprenorphine treatment, dosing of buprenorphine, psychosocial counseling, and treatment of co-occurring depression and anxiety. A total of 65 guideline statements (72%) were rated as valid. Expert panel members had agreement in some areas, such as the treatment of co-occurring mental health problems, but disagreement in others, including the appropriate dosing of buprenorphine given patient complexities. Conclusions: Through an expert panel process, we developed an updated and expanded set of buprenorphine treatment guidelines; this additional guidance may increase credentialed physicians' comfort with prescribing buprenorphine to patients with opioid use disorders. Future efforts should focus on appropriate dosing guidance and ensuring that guidelines can be adapted to a variety of practice settings. C1 [Farmer, Carrie M.; Stein, Bradley D.] RAND Corp, Pittsburgh, PA 15213 USA. [Lindsay, Dawn; Williams, Jessica] Inst Res Educ & Training Addict, Pittsburgh, PA USA. [Gordon, Adam J.] Univ Pittsburgh, Sch Med, Dept Med, Pittsburgh, PA 15213 USA. [Gordon, Adam J.] VA Pittsburgh Healthcare Syst, Mental Illness Res Educ & Clin Ctr, Ctr Hlth Equ Res & Promot, Pittsburgh, PA USA. [Ayers, Amanda; Schuster, James; Cilia, Alyssa] Univ Pittsburgh, Med Ctr, Insurance Div, Community Care Behav Hlth Org, Pittsburgh, PA USA. [Flaherty, Michael T.] Clin Practice, Murrysville, PA USA. [Mandell, Todd] Community Subst Abuse Ctr, Westfield, MA USA. RP Farmer, CM (reprint author), RAND Corp, 4570 Fifth Ave,Suite 600, Pittsburgh, PA 15213 USA. EM cfarmer@rand.org FU NIDA NIH HHS [R01 DA032881] NR 52 TC 4 Z9 4 U1 4 U2 9 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0889-7077 EI 1547-0164 J9 SUBST ABUS JI Subst. Abus. PD APR 3 PY 2015 VL 36 IS 2 SI SI BP 209 EP 216 DI 10.1080/08897077.2015.1012613 PG 8 WC Substance Abuse SC Substance Abuse GA CK6UF UT WOS:000356363100017 PM 25844527 ER PT J AU Wu, E Barnes, DE Ackerman, SL Lee, J Chesney, M Mehling, WE AF Wu, Eveline Barnes, Deborah E. Ackerman, Sara L. Lee, Jennifer Chesney, Margaret Mehling, Wolf E. TI Preventing Loss of Independence through Exercise (PLIe): qualitative analysis of a clinical trial in older adults with dementia SO AGING & MENTAL HEALTH LA English DT Article DE qualitative methods; general; Alzheimer's disease; other dementias ID RANDOMIZED-CONTROLLED-TRIAL; ALZHEIMERS-DISEASE; TAI-CHI; PHYSICAL-ACTIVITY; SUPPORTING SELF; INTERVENTIONS; BALANCE; PEOPLE; METAANALYSIS; INDIVIDUALS AB Objectives: Preventing Loss of Independence through Exercise (PLIe) is a novel, integrative exercise program for individuals with dementia that combines elements of different conventional and complementary exercise modalities (e.g. tai-chi, yoga, Feldenkrais, and dance movement therapy) and focuses on training procedural memory for basic functional movements (e.g., sit-to-stand) while increasing mindful body awareness and facilitating social connection. This study presents analyses of qualitative data collected during a 36-week cross-over pilot clinical trial in 11 individuals. Methods: Qualitative data included exercise instructors' written notes, which were prepared after each class and also following biweekly telephone calls with caregivers and monthly home visits; three video-recorded classes; and written summaries prepared by research assistants following pre- and post-intervention quantitative assessments. Data were extracted for each study participant and placed onto a timeline for month of observation. Data were coded and analyzed to identify themes that were confirmed and refined through an iterative, collaborative process by the entire team including a qualitative researcher (SA) and the exercise instructors. Results: Three overarching themes emerged: (1) Functional changes included increasing body awareness, movement memory and functional skill. (2) Emotional changes included greater acceptance of resting, sharing of personal stories and feelings, and positive attitude toward exercise. (3) Social changes included more coherent social interactions and making friends. Conclusions: These qualitative results suggest that the PLIe program may be associated with beneficial functional, emotional, and social changes for individuals with mild to moderate dementia. Further study of the PLIe program in individuals with dementia is warranted. C1 [Wu, Eveline; Lee, Jennifer; Chesney, Margaret; Mehling, Wolf E.] Univ Calif San Francisco, Osher Ctr Integrat Med, San Francisco, CA 94143 USA. [Wu, Eveline] Calif Inst Integral Studies, Dept Counseling Psychol, San Francisco, CA USA. [Barnes, Deborah E.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA. [Barnes, Deborah E.] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA. [Barnes, Deborah E.] San Francisco VA Med Ctr, San Francisco, CA USA. [Ackerman, Sara L.] Univ Calif San Francisco, Dept Social & Behav Sci, San Francisco, CA USA. [Mehling, Wolf E.] Univ Calif San Francisco, Dept Family & Community Med, San Francisco, CA 94143 USA. RP Mehling, WE (reprint author), Univ Calif San Francisco, Osher Ctr Integrat Med, San Francisco, CA 94143 USA. EM mehlingw@ocim.ucsf.edu NR 55 TC 5 Z9 6 U1 9 U2 201 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1360-7863 EI 1364-6915 J9 AGING MENT HEALTH JI Aging Ment. Health PD APR 3 PY 2015 VL 19 IS 4 BP 353 EP 362 DI 10.1080/13607863.2014.935290 PG 10 WC Geriatrics & Gerontology; Gerontology; Psychiatry SC Geriatrics & Gerontology; Psychiatry GA AZ6EP UT WOS:000348311900007 PM 25022459 ER PT J AU Ramos, AD Andersen, RE Liu, SJ Nowakowski, TJ Hong, SJ Gertz, CC Salinas, RD Zarabi, H Kriegstein, AR Lim, DA AF Ramos, Alexander D. Andersen, Rebecca E. Liu, Siyuan John Nowakowski, Tomasz Jan Hong, Sung Jun Gertz, Caitlyn C. Salinas, Ryan D. Zarabi, Hosniya Kriegstein, Arnold R. Lim, Daniel A. TI The Long Noncoding RNA Pnky Regulates Neuronal Differentiation of Embryonic and Postnatal Neural Stem Cells SO CELL STEM CELL LA English DT Article ID TRACT-BINDING-PROTEINS; ADULT MAMMALIAN BRAIN; SUBVENTRICULAR ZONE; EPIGENETIC REGULATION; GENE-EXPRESSION; IN-VIVO; PTBP2; NEUROGENESIS; TRANSCRIPTS; PROGRESSION AB While thousands of long noncoding RNAs (IncRNAs) have been identified, few IncRNAs that control neural stem cell (NSC) behavior are known. Here, we identify Pinky (Pnky) as a neural-specific IncRNA that regulates neurogenesis from NSCs in the embryonic and postnatal brain. In postnatal NSCs, Pnky knockdown potentiates neuronal lineage commitment and expands the transit-amplifying cell population, increasing neuron production several-fold. Pnky is evolutionarily conserved and expressed in NSCs of the developing human brain. In the embryonic mouse cortex, Pnky knockdown increases neuronal differentiation and depletes the NSC population. Pnky interacts with the splicing regulator PTBP1, and PTBP1 knockdown also enhances neurogenesis. In NSCs, Pnky and PTBP1 regulate the expression and alternative splicing of a core set of transcripts that relates to the cellular phenotype. These data thus unveil Pnky as a conserved IncRNA that interacts with a key RNA processing factor and regulates neurogenesis from embryonic and postnatal NSC populations. C1 [Ramos, Alexander D.; Andersen, Rebecca E.; Liu, Siyuan John; Hong, Sung Jun; Salinas, Ryan D.; Zarabi, Hosniya; Lim, Daniel A.] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94143 USA. [Ramos, Alexander D.; Andersen, Rebecca E.; Liu, Siyuan John; Nowakowski, Tomasz Jan; Hong, Sung Jun; Gertz, Caitlyn C.; Salinas, Ryan D.; Zarabi, Hosniya; Kriegstein, Arnold R.; Lim, Daniel A.] Univ Calif San Francisco, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, San Francisco, CA 94143 USA. [Ramos, Alexander D.; Liu, Siyuan John] Univ Calif San Francisco, Med Sci Training Program, Biomed Sci Grad Program, San Francisco, CA 94143 USA. [Andersen, Rebecca E.] Univ Calif San Francisco, Dev & Stem Cell Biol Grad Program, San Francisco, CA 94143 USA. [Nowakowski, Tomasz Jan; Gertz, Caitlyn C.; Kriegstein, Arnold R.] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA. [Gertz, Caitlyn C.] Univ Calif San Francisco, Neurosci Grad Program, San Francisco, CA 94143 USA. [Hong, Sung Jun] San Francisco State Univ, CIRM Bridges Scholar Program, San Francisco, CA 94132 USA. [Lim, Daniel A.] San Francisco VA Med Ctr, San Francisco, CA 94121 USA. RP Lim, DA (reprint author), Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94143 USA. EM daniel.lim@ucsf.edu FU NIH [DP2-OD006505-01, VA 1I01 BX000252-04, R01 NS35710, 1F31NS080501-01A1]; Shurl and Kay Curci Foundation Award; National Science Foundation Graduate Research Fellowship [1144247]; MSTP [2T32GM007618-34]; SFSU CIRM Bridges fellowship [TB1-01194]; HHMI Medical Research Fellowship FX We thank Robert Darnell for the PTBP2 antibody; David Weinberg for helpful discussions; Kenneth Probst for help with the graphical abstract; and Ewa Witkowski, Steven Hall, and The Sandler-Moore Mass Spectrometry Core Facility at UCSF for help with mass spectrometry. This project was supported by NIH DP2-OD006505-01, VA 1I01 BX000252-04, and a Shurl and Kay Curci Foundation Award to D.A.L; NIH R01 NS35710 to A.R.K.; NIH 1F31NS080501-01A1 to A.D.R.; National Science Foundation Graduate Research Fellowship Grant No. 1144247 to R.E.A.; MSTP training grant 2T32GM007618-34 to S.J.L.; SFSU CIRM Bridges TB1-01194 fellowship to S.H.; HHMI Medical Research Fellowship to H.Z.; and facilities and resources provided by the San Francisco Veterans Affairs Medical Center. NR 44 TC 44 Z9 49 U1 3 U2 26 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 1934-5909 EI 1875-9777 J9 CELL STEM CELL JI Cell Stem Cell PD APR 2 PY 2015 VL 16 IS 4 BP 439 EP 447 DI 10.1016/j.stem.2015.02.007 PG 9 WC Cell & Tissue Engineering; Cell Biology SC Cell Biology GA CF0JD UT WOS:000352228600015 PM 25800779 ER PT J AU Aikens, JE Vogel, M Illes, RA Safford, MM Andreae, SJ Koenig, CJ Maguen, S Seal, K Mayott, LK AF Aikens, James E. Vogel, Mark Illes, Rose Ann Safford, Monika M. Andreae, Susan J. Koenig, Christopher J. Maguen, Shira Seal, Karen Mayott, Lindsay K. TI IMPROVING PRIMARY CARE THROUGH CULTURALLY RESPONSIVE INITIATIVES SO ANNALS OF BEHAVIORAL MEDICINE LA English DT Meeting Abstract C1 [Aikens, James E.] Univ Michigan, Ann Arbor, MI 48109 USA. [Vogel, Mark] Genesys Reg Med Ctr, Burton, MI USA. [Illes, Rose Ann] Florida State Univ, Ft Myers, FL USA. [Safford, Monika M.; Andreae, Susan J.] Univ Alabama Birmingham, Birmingham, AL USA. [Koenig, Christopher J.] UCSF, San Francisco Vet Affairs Med Ctr, San Francisco, CA USA. [Maguen, Shira] San Francis VA Med Ctr, San Francisco, CA USA. [Maguen, Shira] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Seal, Karen] UCSF, San Francisco VA Med Ctr, San Francisco, CA USA. [Mayott, Lindsay K.] Columbia Univ, Teachers Coll, New York, NY 10027 USA. EM roseanne.illes@leememorial.org; msafford@uab.edu; christopher.koenig@ucsf.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0883-6612 EI 1532-4796 J9 ANN BEHAV MED JI Ann. Behav. Med. PD APR PY 2015 VL 49 SU 1 MA 31 BP S132 EP S132 PG 1 WC Psychology, Multidisciplinary SC Psychology GA DA5EH UT WOS:000367825002009 ER PT J AU Millstein, R Hoerster, K Rosenberg, D Nelson, K Reiber, GE Saelens, B AF Millstein, Rachel Hoerster, Katherine Rosenberg, Dori Nelson, Karin Reiber, Gayle E. Saelens, Brian TI INDIVIDUAL, SOCIAL, AND NEIGHBORHOOD ASSOCIATIONS WITH SITTING TIME AMONG VETERANS SO ANNALS OF BEHAVIORAL MEDICINE LA English DT Meeting Abstract C1 [Millstein, Rachel] MGH, Boston, MA 02114 USA. [Hoerster, Katherine] VA Puget Sound Healthcare Syst, Seattle, WA USA. [Rosenberg, Dori] Grp Hlth Res Inst, Seattle, WA USA. [Nelson, Karin] Univ Washington, VA Puget Sound, Seattle, WA 98195 USA. [Reiber, Gayle E.] VA Puget Sound, Lake Forest Pk, WA USA. [Saelens, Brian] Univ Washington, Seattle Childrens Res Inst, Seattle, WA 98195 USA. EM rmillstein@gmail.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0883-6612 EI 1532-4796 J9 ANN BEHAV MED JI Ann. Behav. Med. PD APR PY 2015 VL 49 SU 1 MA C104 BP S200 EP S200 PG 1 WC Psychology, Multidisciplinary SC Psychology GA DA5EH UT WOS:000367825002275 ER PT J AU Richardson, CR Damschroder, L Moin, T Estabrooks, P AF Richardson, Caroline R. Damschroder, Laura Moin, Tannaz Estabrooks, Paul TI IMPLEMENTING DIABETES PREVENTION IN THE VA - RESULTS FROM A CLINICAL DEMONSTRATION PROJECT SO ANNALS OF BEHAVIORAL MEDICINE LA English DT Meeting Abstract C1 [Richardson, Caroline R.] Univ Michigan, Ann Arbor VA Med Ctr, Ann Arbor, MI 48109 USA. [Damschroder, Laura] VA Ann Arbor Ctr Clin Management Res, Ann Arbor, MI USA. [Moin, Tannaz] VA Greater Los Angeles, Los Angeles, CA USA. [Estabrooks, Paul] Virginia Tech, Caril Clin, Virginia Tech Caril Sch Med, Blacksburg, VA USA. EM caroli@umich.edu; laura.damschroder@va.gov; tmoin@mednet.ucla.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0883-6612 EI 1532-4796 J9 ANN BEHAV MED JI Ann. Behav. Med. PD APR PY 2015 VL 49 SU 1 MA 30 BP S131 EP S131 PG 1 WC Psychology, Multidisciplinary SC Psychology GA DA5EH UT WOS:000367825002005 ER PT J AU Teo, AR AF Teo, Alan R. TI SHALL WE MEET UP? MODE AND FREQUENCY OF SOCIAL CONTACT AS A PREDICTOR FOR DEPRESSION IN THE ELDERLY SO ANNALS OF BEHAVIORAL MEDICINE LA English DT Meeting Abstract C1 [Teo, Alan R.] Portland VA Med Ctr, Portland, OR USA. EM teoa@ohsu.edu NR 0 TC 0 Z9 0 U1 3 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0883-6612 EI 1532-4796 J9 ANN BEHAV MED JI Ann. Behav. Med. PD APR PY 2015 VL 49 SU 1 MA D045 BP S234 EP S234 PG 1 WC Psychology, Multidisciplinary SC Psychology GA DA5EH UT WOS:000367825002411 ER PT J AU Mitsui, J Matsukawa, T Sasaki, H Yabe, I Matsushima, M Durr, A Brice, A Takashima, H Kikuchi, A Aoki, M Ishiura, H Yasuda, T Date, H Ahsan, B Iwata, A Goto, J Ichikawa, Y Nakahara, Y Momose, Y Takahashi, Y Hara, K Kakita, A Yamada, M Takahashi, H Onodera, O Nishizawa, M Watanabe, H Ito, M Sobue, G Ishikawa, K Mizusawa, H Kanai, K Hattori, T Kuwabara, S Arai, K Koyano, S Kuroiwa, Y Hasegawa, K Yuasa, T Yasui, K Nakashima, K Ito, H Izumi, Y Kaji, R Kato, T Kusunoki, S Osaki, Y Horiuchi, M Kondo, T Murayama, S Hattori, N Yamamoto, M Murata, M Satake, W Toda, T Filla, A Klockgether, T Wullner, U Nicholson, G Gilman, S Tanner, CM Kukull, WA Stern, MB Lee, VMY Trojanowski, JQ Masliah, E Low, PA Sandroni, P Ozelius, LJ Foroud, T Tsuji, S AF Mitsui, Jun Matsukawa, Takashi Sasaki, Hidenao Yabe, Ichiro Matsushima, Masaaki Duerr, Alexandra Brice, Alexis Takashima, Hiroshi Kikuchi, Akio Aoki, Masashi Ishiura, Hiroyuki Yasuda, Tsutomu Date, Hidetoshi Ahsan, Budrul Iwata, Atsushi Goto, Jun Ichikawa, Yaeko Nakahara, Yasuo Momose, Yoshio Takahashi, Yuji Hara, Kenju Kakita, Akiyoshi Yamada, Mitsunori Takahashi, Hitoshi Onodera, Osamu Nishizawa, Masatoyo Watanabe, Hirohisa Ito, Mizuki Sobue, Gen Ishikawa, Kinya Mizusawa, Hidehiro Kanai, Kazuaki Hattori, Takamichi Kuwabara, Satoshi Arai, Kimihito Koyano, Shigeru Kuroiwa, Yoshiyuki Hasegawa, Kazuko Yuasa, Tatsuhiko Yasui, Kenichi Nakashima, Kenji Ito, Hijiri Izumi, Yuishin Kaji, Ryuji Kato, Takeo Kusunoki, Susumu Osaki, Yasushi Horiuchi, Masahiro Kondo, Tomoyoshi Murayama, Shigeo Hattori, Nobutaka Yamamoto, Mitsutoshi Murata, Miho Satake, Wataru Toda, Tatsushi Filla, Alessandro Klockgether, Thomas Wuellner, Ullrich Nicholson, Garth Gilman, Sid Tanner, Caroline M. Kukull, Walter A. Stern, Mathew B. Lee, Virginia M. -Y. Trojanowski, John Q. Masliah, Eliezer Low, Phillip A. Sandroni, Paola Ozelius, Laurie J. Foroud, Tatiana Tsuji, Shoji TI Variants associated with Gaucher disease in multiple system atrophy SO ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY LA English DT Article ID GLIAL CYTOPLASMIC INCLUSIONS; ALPHA-SYNUCLEIN; PARKINSONS-DISEASE; GLUCOCEREBROSIDASE MUTATIONS; OLIVOPONTOCEREBELLAR ATROPHY; LEWY BODIES; TYPE-1; SNCA; MULTICENTER; ALLELES AB Objective: Glucocerebrosidase gene (GBA) variants that cause Gaucher disease are associated with Parkinson disease (PD) and dementia with Lewy bodies (DLB). To investigate the role of GBA variants in multiple system atrophy (MSA), we analyzed GBA variants in a large case-control series. Methods: We sequenced coding regions and flanking splice sites of GBA in 969 MSA patients (574 Japanese, 223 European, and 172 North American) and 1509 control subjects (900 Japanese, 315 European, and 294 North American). We focused solely on Gaucher-disease-causing GBA variants. Results: In the Japanese series, we found nine carriers among the MSA patients (1.65%) and eight carriers among the control subjects (0.89%). In the European series, we found three carriers among the MSA patients (1.35%) and two carriers among the control subjects (0.63%). In the North American series, we found five carriers among the MSA patients (2.91%) and one carrier among the control subjects (0.34%). Subjecting each series to a Mantel-Haenszel analysis yielded a pooled odds ratio (OR) of 2.44 (95% confidence interval [CI], 1.14-5.21) and a P-value of 0.029 without evidence of significant heterogeneity. Logistic regression analysis yielded similar results, with an adjusted OR of 2.43 (95% CI 1.15-5.37) and a P-value of 0.022. Subtype analysis showed that Gaucher-disease-causing GBA variants are significantly associated with MSA cerebellar subtype (MSA-C) patients (P = 7.3 9 10(-3)). Interpretation: The findings indicate that, as in PD and DLB, Gaucher-disease-causing GBA variants are associated with MSA. C1 [Mitsui, Jun; Matsukawa, Takashi; Ishiura, Hiroyuki; Yasuda, Tsutomu; Date, Hidetoshi; Ahsan, Budrul; Iwata, Atsushi; Goto, Jun; Ichikawa, Yaeko; Nakahara, Yasuo; Momose, Yoshio; Takahashi, Yuji; Tsuji, Shoji] Univ Tokyo, Grad Sch Med, Dept Neurol, Tokyo, Japan. [Sasaki, Hidenao; Yabe, Ichiro; Matsushima, Masaaki] Hokkaido Univ, Grad Sch Med, Dept Neurol, Sapporo, Hokkaido, Japan. [Duerr, Alexandra; Brice, Alexis] Univ Paris 06, Univ Sorbonne 3, Hop La Pitie Salpetriere,CNRS,UMR 7225,UM 75,ICM, AP HP,Dept Genet & Cytogenet,INSERM,U1127, F-75013 Paris, France. [Takashima, Hiroshi] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Neurol & Geriatr, Kagoshima 890, Japan. [Kikuchi, Akio; Aoki, Masashi] Tohoku Univ, Sch Med, Dept Neurol, Sendai, Miyagi 980, Japan. [Hara, Kenju; Onodera, Osamu; Nishizawa, Masatoyo] Niigata Univ, Brain Res Inst, Dept Neurol, Niigata 951, Japan. [Kakita, Akiyoshi; Yamada, Mitsunori; Takahashi, Hitoshi] Niigata Univ, Brain Res Inst, Dept Pathol, Niigata, Japan. [Watanabe, Hirohisa; Ito, Mizuki; Sobue, Gen] Natl Hosp Org, Dept Clin Res, Saigata Med Ctr, Niigata, Japan. [Watanabe, Hirohisa; Ito, Mizuki; Sobue, Gen] Nagoya Univ, Grad Sch Med, Dept Neurol, Nagoya, Aichi 4648601, Japan. [Ishikawa, Kinya; Mizusawa, Hidehiro] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Neurol & Neurol Sci, Tokyo, Japan. [Kanai, Kazuaki; Hattori, Takamichi; Kuwabara, Satoshi] Chiba Univ, Sch Med, Dept Neurol, Chiba 280, Japan. [Arai, Kimihito] Natl Hosp Org, Chiba East Hosp, Div Neurol, Chiba, Japan. [Koyano, Shigeru] Yokohama City Univ, Grad Sch Med, Dept Clin Neurol & Stroke Med, Yokohama, Kanagawa 232, Japan. [Kuroiwa, Yoshiyuki] Teikyo Univ, Sch Med, Univ Hosp, Dept Neurol, Kawasaki, Kanagawa, Japan. [Hasegawa, Kazuko] Natl Hosp Org, Sagamihara Natl Hosp, Div Neurol, Sagamihara, Kanagawa, Japan. [Yuasa, Tatsuhiko] Kamagaya Gen Hosp, Kamagaya Chiba Med Ctr Intractable Neurol Dis, Dept Neurol, Chiba, Japan. [Yasui, Kenichi; Nakashima, Kenji] Tottori Univ, Fac Med, Dept Brain & Neurosci, Div Neurol, Yonago, Tottori 683, Japan. [Ito, Hijiri] Mifukai Vihara Hananosato Hosp, Dept Neurol, Hiroshima, Japan. [Izumi, Yuishin; Kaji, Ryuji] Univ Tokushima, Grad Sch, Inst Hlth Biosci, Dept Clin Neurosci, Tokushima 770, Japan. [Kato, Takeo] Yamagata Univ, Fac Med, Dept Neurol, Yamagata 990, Japan. [Kato, Takeo] Yamagata Univ, Fac Med, Dept Hematol, Yamagata 990, Japan. [Kato, Takeo] Yamagata Univ, Fac Med, Dept Metab, Yamagata 990, Japan. [Kato, Takeo] Yamagata Univ, Fac Med, Dept Endocrinol, Yamagata 990, Japan. [Kato, Takeo] Yamagata Univ, Fac Med, Dept Diabetol, Yamagata 990, Japan. [Kusunoki, Susumu] Kinki Univ, Sch Med, Dept Neurol, Osaka 589, Japan. [Osaki, Yasushi] Kochi Med Sch, Dept Geriatr Cardiol & Neurol, Nankoku, Kochi, Japan. [Horiuchi, Masahiro] St Marianna Univ, Sch Med, Dept Internal Med, Div Neurol, Kawasaki, Kanagawa, Japan. [Kondo, Tomoyoshi] Wakayama Med Univ, Dept Neurol, Wakayama, Japan. [Murayama, Shigeo] Tokyo Metropolitan Geriatr Hosp, Dept Neuropathol, Tokyo 173, Japan. [Murayama, Shigeo] Tokyo Metropolitan Geriatr Hosp, Brain Bank Aging Res, Tokyo 173, Japan. [Murayama, Shigeo] Inst Gerontol, Tokyo, Japan. [Hattori, Nobutaka] Juntendo Univ, Sch Med, Dept Neurol, Tokyo 113, Japan. [Yamamoto, Mitsutoshi] Kagawa Prefectural Cent Hosp, Dept Neurol, Takamatsu, Kagawa, Japan. [Murata, Miho] Natl Ctr Hosp Neurol & Psychiat, Dept Neurol, Tokyo, Japan. [Satake, Wataru; Toda, Tatsushi] Kobe Univ, Grad Sch Med, Div Neurol Mol Brain Sci, Kobe, Hyogo 657, Japan. [Filla, Alessandro] Univ Naples Federico II, Dept Neurol Sci, Naples, Italy. [Klockgether, Thomas; Wuellner, Ullrich] Univ Bonn, Dept Neurol, Bonn, Germany. [Klockgether, Thomas; Wuellner, Ullrich] German Ctr Neurodegenerat Dis DZNE, Bonn, Germany. [Nicholson, Garth] Univ Sydney, Concord Hosp, Australian & New Zealand Army Corps ANZAC Res Ins, Sydney, NSW 2006, Australia. [Gilman, Sid] Univ Michigan, Dept Neurol, Ann Arbor, MI USA. [Tanner, Caroline M.] San Francisco VA Med Ctr, Parkinsons Dis Res Educ & Clin Ctr, San Francisco, CA USA. [Kukull, Walter A.] Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA. [Stern, Mathew B.] Univ Penn, Dept Neurol, Perelman Sch Med, Parkinsons Dis & Movement Disorders Ctr, Philadelphia, PA 19104 USA. [Kikuchi, Akio; Lee, Virginia M. -Y.; Trojanowski, John Q.] Univ Penn, Perelman Sch Med, Udall Parkinsons Res Ctr, Inst Aging, Philadelphia, PA 19104 USA. [Lee, Virginia M. -Y.; Trojanowski, John Q.] Univ Penn, Perelman Sch Med, Ctr Neurodegenerat Dis Res, Philadelphia, PA 19104 USA. [Lee, Virginia M. -Y.; Trojanowski, John Q.] Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA. [Masliah, Eliezer] Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA. [Low, Phillip A.; Sandroni, Paola] Mayo Clin, Dept Neurol, Rochester, MN USA. [Ozelius, Laurie J.] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA. [Ozelius, Laurie J.] Icahn Sch Med Mt Sinai, Dept Neurol, New York, NY 10029 USA. [Foroud, Tatiana] Indiana Univ Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46202 USA. RP Tsuji, S (reprint author), 7-3-1 Hongo, Tokyo 1138655, Japan. EM tsuji@m.u-tokyo.ac.jp RI Iwata, Atsushi/A-9598-2013; Onodera, Osamu/K-7327-2013 OI Iwata, Atsushi/0000-0001-7308-5314; Onodera, Osamu/0000-0003-3354-5472 FU NIA NIH HHS [P50 AG005131, U01 AG016976]; NINDS NIH HHS [P01 NS044233, P50 NS053488] NR 36 TC 14 Z9 14 U1 0 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2328-9503 J9 ANN CLIN TRANSL NEUR JI Ann. Clin. Transl. Neurol. PD APR PY 2015 VL 2 IS 4 BP 417 EP 426 DI 10.1002/acn3.185 PG 10 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA CZ3CJ UT WOS:000366981500008 PM 25909086 ER PT J AU Anselmi, L Huynh, J Duraffourd, C Jaramillo, I Vegezzi, G Saccani, F Boschetti, E Brecha, NC De Giorgio, R Sternini, C AF Anselmi, L. Huynh, J. Duraffourd, C. Jaramillo, I. Vegezzi, G. Saccani, F. Boschetti, E. Brecha, N. C. De Giorgio, R. Sternini, C. TI Activation of mu opioid receptors modulates inflammation in acute experimental colitis SO NEUROGASTROENTEROLOGY AND MOTILITY LA English DT Article DE antiapoptotic factor; cytokines; inflammatory indexes; transcriptional nuclear factor-kB ID NF-KAPPA-B; RAT GASTROINTESTINAL-TRACT; GUINEA-PIG ILEUM; IMMUNE-SYSTEM; CELL-DEATH; INTESTINAL ISCHEMIA/REPERFUSION; GENE-EXPRESSION; BOWEL DISEASES; MICE LACKING; MECHANISMS AB Background mu opioid receptors (mu ORs) are expressed by neurons and inflammatory cells, and mediate immune response. We tested whether activation of peripheral mu ORs ameliorates the acute and delayed phase of colitis. Methods C57BL/6J mice were treated with 3% dextran sodium sulfate (DSS) in water, 5 days with or without the peripherally acting mu OR agonist, [D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin (DAMGO) or with DAMGO+mu OR antagonist at day 2-5, then euthanized. Other mice received DSS followed by water for 4 weeks, or DSS with DAMGO starting at day 2 of DSS for 2 or 3 weeks followed by water, then euthanized at 4 weeks. Disease activity index (DAI), histological damage, and myeloperoxidase assay (MPO), as index of neutrophil infiltration, were evaluated. Cytokines and mu OR mRNAs were measured with RT-PCR, and nuclear factor-kB (NF-kB), the antiapoptotic factor Bcl-xL, and caspase 3 and 7 with Western blot. Key Results DSS induced acute colitis with elevated DAI, tissue damage, apoptosis and increased MPO, cytokines, mu OR mRNA, and NF-kB. DAMGO significantly reduced DAI, inflammatory indexes, cytokines, caspases, and NF-kB, and upregulated Bcl-xL, effects prevented by lOR antagonist. In DSS mice plus 4 weeks of water, DAI, NF-kB, and lOR were normal, whereas MPO, histological damage, and cytokines were still elevated; DAMGO did not reduce inflammation, and did not upregulate Bcl-xL. Conclusions & Inferences lOR activation ameliorated the acute but not the delayed phase of DSS colitis by reducing cytokines, likely through activation of the antiapoptotic factor, Bcl-xL, and suppression of NF-kB, a potentiator of inflammation. C1 [Anselmi, L.; Huynh, J.; Duraffourd, C.; Jaramillo, I.; Vegezzi, G.; Saccani, F.; Brecha, N. C.; Sternini, C.] Univ Calif Los Angeles, David Geffen Sch Med, Div Digest Dis, CURE Digest Dis Res Ctr, Los Angeles, CA 90095 USA. [Anselmi, L.; Huynh, J.; Duraffourd, C.; Jaramillo, I.; Vegezzi, G.; Saccani, F.; Brecha, N. C.; Sternini, C.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA. [Duraffourd, C.; Brecha, N. C.; Sternini, C.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA. [Boschetti, E.; De Giorgio, R.] Univ Bologna, St Orsola Malpighi Hosp, CRBA, Dept Med & Surg Sci, Bologna, Italy. [Brecha, N. C.; Sternini, C.] Vet Adm Greater Los Angeles Hlth Syst, Los Angeles, CA USA. RP Sternini, C (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Div Digest Dis, CURE DDRC, 650 C Young Dr South,CHS 44-146, Los Angeles, CA 90095 USA. EM csternin@ucla.edu RI Boschetti, Elisa/J-3684-2016 OI Boschetti, Elisa/0000-0003-4503-2770 FU National Institutes of Health [R01 DK54155, P30 DK41301]; Morphology and Cell Imaging Core; VA Career Research Scientist Award; Italian Ministry of Education, University and Research (MIUR) (PRIN); Fondazione Del Monte di Bologna e Ravenna, Italy FX This work was supported by the National Institutes of Health, R01 DK54155 (to C.S.) and P30 DK41301, Morphology and Cell Imaging Core (to C.S.), a VA Career Research Scientist Award (to N.C.B) and Italian Ministry of Education, University and Research (MIUR) (PRIN2009) and Fondazione Del Monte di Bologna e Ravenna, Italy (to R.D.G.). NR 58 TC 7 Z9 8 U1 1 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1350-1925 EI 1365-2982 J9 NEUROGASTROENT MOTIL JI Neurogastroenterol. Motil. PD APR PY 2015 VL 27 IS 4 BP 509 EP 523 DI 10.1111/nmo.12521 PG 15 WC Gastroenterology & Hepatology; Clinical Neurology; Neurosciences SC Gastroenterology & Hepatology; Neurosciences & Neurology GA CW1HR UT WOS:000364740900007 PM 25690069 ER PT J AU Basu, PP Shah, NJ Brown, R AF Basu, P. P. Shah, N. J. Brown, R., Jr. TI SIMEPREVIR AND SOFOSBUVIR WITH MODIFIED DOSES OF RIBAVIRIN (RBV) THERAPY ON TELAPREVIR EXPERIENCED CO INFECTED (WITH HIV) CIRRHOTICS WITH CHRONIC HEPATITIS C (CHC). A RANDOMIZED OPEN LABEL CLINICAL PILOT STUDY: STOP C SO JOURNAL OF HEPATOLOGY LA English DT Meeting Abstract CT 50th International Liver Congress of the European-Association-for-the-Study-of-the-Liver CY APR 22-26, 2015 CL Vienna, AUSTRIA SP European Assoc Study Liver C1 [Basu, P. P.; Brown, R., Jr.] Columbia Univ Coll Phys & Surg, New York, NY USA. [Basu, P. P.] Kings Cty Hosp, Med Ctr, Brooklyn, NY USA. [Shah, N. J.] Icahn Sch Med Mt Sinai, James J Peters VA Med Ctr, New York, NY 10029 USA. EM basu.patrick@gmail.com NR 0 TC 2 Z9 2 U1 1 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-8278 EI 1600-0641 J9 J HEPATOL JI J. Hepatol. PD APR PY 2015 VL 62 SU 2 MA P0819 BP S643 EP S643 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA CT5EL UT WOS:000362830900014 ER PT J AU Lee, A Polgar, N Lui, V Tamashiro, KK Napoli, JA Lipschutz, J Fogelgren, B AF Lee, Amanda Polgar, Noemi Lui, Vanessa Tamashiro, Kadee-Kalia Napoli, Josephine Andrea Lipschutz, Joshua Fogelgren, Ben TI A Novel Transgenic Mouse Model for Congenital Obstructive Nephropathy SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY MAR 28-APR 01, 2015 CL Boston, MA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET C1 [Lee, Amanda; Polgar, Noemi; Lui, Vanessa; Tamashiro, Kadee-Kalia; Napoli, Josephine Andrea; Fogelgren, Ben] Univ Hawaii, Anat Biochem & Physiol, Honolulu, HI 96822 USA. [Lipschutz, Joshua] Med Univ S Carolina, Med, Charleston, SC 29425 USA. [Lipschutz, Joshua] Ralph Johnson Vet Affairs Med Ctr, Med, Charleston, SC USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 663.16 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CS0BT UT WOS:000361722700017 ER PT J AU Roy, A Goodman, J Pittman, G Begum, G Donnelly, B Sun, D Subramanya, A AF Roy, Ankita Goodman, Joshua Pittman, Gabrielle Begum, Gulnaz Donnelly, Bridget Sun, Dandan Subramanya, Arohan TI CRISPR/Cas mediated genome editing reveals new insights into the WNK-SPAK/OSR1 network SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY MAR 28-APR 01, 2015 CL Boston, MA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET C1 [Roy, Ankita; Goodman, Joshua; Pittman, Gabrielle; Donnelly, Bridget; Subramanya, Arohan] Univ Pittsburgh, Med, Pittsburgh, PA 15260 USA. [Begum, Gulnaz; Sun, Dandan] Univ Pittsburgh, Neurol, Pittsburgh, PA 15260 USA. [Subramanya, Arohan] VA Pittsburgh Healthcare Syst, Res Serv, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 969.20 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CS0BT UT WOS:000361722706486 ER PT J AU Toba, H Bras, LD Baicu, C Zile, M Lindsey, M Bradshaw, A AF Toba, Hiroe Bras, Lisandra de Castro Baicu, Catalin Zile, Michael Lindsey, Merry Bradshaw, Amy TI SPARC Facilitates Inflammation in the Aging Heart and Suppresses Macrophage M2 Polarization SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY MAR 28-APR 01, 2015 CL Boston, MA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET C1 [Toba, Hiroe; Bras, Lisandra de Castro; Lindsey, Merry] UMMC, Physiol & Biophys, MS Ctr Heart Res, Jackson, MS USA. [Toba, Hiroe; Bras, Lisandra de Castro; Lindsey, Merry] UMMC, Physiol & Biophys, San Antonio CV Prote Ctr, Jackson, MS USA. [Toba, Hiroe] Kyoto Pharmaceut Univ, Clin Pharmacol, Kyoto 607, Japan. [Baicu, Catalin; Zile, Michael; Bradshaw, Amy] Med MUSC, Gazes Cardiac Res Inst, Charleston, SC USA. [Zile, Michael; Bradshaw, Amy] Ralph H Johnson VA Med Ctr, Charleston, SC USA. [Lindsey, Merry] GV Sonny Montgomery VA Med Ctr, Jackson, MS USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 1047.1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CS0BT UT WOS:000361722708092 ER PT J AU Voruganti, VS Haack, K Laston, S Goring, H Best, L Howard, B MacCluer, J Umans, J Cole, S Cohen, D AF Voruganti, V. Saroja Haack, Karin Laston, Sandra Goring, Harald Best, Lyle Howard, Barbara MacCluer, Jean Umans, Jason Cole, Shelley Cohen, David TI Sex-Specific Effects Of NPHP1 And SLC9A2 SNPs On Systemic Water Balance In American Indians SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY MAR 28-APR 01, 2015 CL Boston, MA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, ASIP, ASN, ASPET C1 [Voruganti, V. Saroja] UNC, Nutr, Chapel Hill, NC USA. [Voruganti, V. Saroja] UNC, Inst Nutr Res, Chapel Hill, NC USA. [Haack, Karin; Laston, Sandra; Goring, Harald; MacCluer, Jean; Cole, Shelley] Texas Biomed Res Inst, Genet, Houston, TX USA. [Best, Lyle] Missouri Breaks Ind Res Inc, Kansas City, MO USA. [Howard, Barbara; Umans, Jason] Medstar, Hlth Res Inst, Washington, DC USA. [Howard, Barbara; Umans, Jason] Georgetown Howard Univ Ctr Clin & Translat Sci, Washington, DC USA. [Cohen, David] Oregon Hlth & Sci Univ, Med, Portland, OR 97201 USA. [Cohen, David] Portland VA Med Ctr, Portland, OR USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 748.6 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CS0BT UT WOS:000361722702210 ER PT J AU Senkal, C Hannun, Y Obeid, L AF Senkal, Can Hannun, Yusuf Obeid, Lina TI Interaction of Ceramide Synthase with Long Chain Fatty Acyl-CoA Synthase 5 Channels de novo Ceramide to Acylceramide Generation by Diacylglycerol Acyltransferase 2 on Lipid Droplets SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Senkal, Can; Hannun, Yusuf; Obeid, Lina] SUNY Stony Brook, Dept Med, Stony Brook, NY 11794 USA. [Hannun, Yusuf] SUNY Stony Brook, Stony Brook Canc Ctr, Stony Brook, NY 11794 USA. [Obeid, Lina] US Dept Vet Affairs, Northport Vet Affairs Med Ctr, Northport, NY USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2015 VL 29 SU 1 MA 568.21 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CR6PV UT WOS:000361470504100 ER PT J AU Sakamoto, M Hilsabeck, RC Hammel, M Barakat, F Hassanein, T Perry, W AF Sakamoto, Maiko Hilsabeck, Robin C. Hammel, Meghan Barakat, Fatma Hassanein, Tarek Perry, William TI Neuropsychological functioning among individuals infected with hepatitis C: a comparison of pre- and post-transplant performance SO NEUROPSYCHOLOGICAL TRENDS LA English DT Article DE Hepatitis C; Liver transplantation; Cognitive impairment; Depressive symptoms; End stage liver disease ID QUALITY-OF-LIFE; STAGE LIVER-DISEASE; COGNITIVE DYSFUNCTION; TRANSPLANT RECIPIENTS; HIV-INFECTION; ENCEPHALOPATHY; IMPAIRMENT; IMPACT; CIRRHOSIS; VIRUS AB It is well established that patients with end stage liver disease (ESLD) experience cognitive and mood problems; however, little is known about changes in cognitive and emotional functioning following liver transplantation, especially over the past decade with the epidemic of hepatitis C virus (HCV) infection taking over as the leading indication for liver transplantation. Seventeen patients with ESLD secondary to chronic HCV were assessed pre- and post-liver transplantation using a comprehensive neuropsychological battery. After an average of four years post-transplant, patients demonstrated significant improvements in most cognitive functioning and depressive symptoms. However, 18% of liver recipients continued to exhibit mild cognitive impairment mainly in areas of attention/executive functioning, motor speed, and learning. Liver transplantation is a life-extending surgery that reverses most, but not all, cognitive and mood difficulties. It is crucial to evaluate cognition after liver transplantation, especially in these three domains, and to consider the effect on daily functioning. C1 [Sakamoto, Maiko; Hilsabeck, Robin C.; Hammel, Meghan; Perry, William] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA. [Sakamoto, Maiko] Saga Univ, Sch Med, Saga 840, Japan. [Hilsabeck, Robin C.] Univ Texas Hlth Sci Ctr San Antonio, Dept Psychiat, San Antonio, TX 78229 USA. [Hilsabeck, Robin C.] South Texas Vet Hlth Care Syst, San Antonio, TX USA. [Barakat, Fatma; Hassanein, Tarek] Southern Calif Liver Ctr, Coronado, CA USA. RP Sakamoto, M (reprint author), Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA. EM thassanein@livercenters.com NR 60 TC 0 Z9 0 U1 2 U2 2 PU EDIZIONI UNIV LETTERE ECONOMIC DIRITTO-LED PI MILAN PA VIA CERVIGNANO 4,, MILAN, 20137, ITALY SN 1970-321X EI 1970-3201 J9 NEUROPSYCHOL TRENDS JI Neuropsychol. Trends PD APR PY 2015 IS 17 BP 67 EP 83 DI 10.7358/neur-2015-017-saka PG 17 WC Psychology SC Psychology GA CM2MC UT WOS:000357513400007 ER PT J AU Ahluwalia, S Cromer, R Giannitrapani, K Schreibeis-Baum, H Dobscha, S Krebs, EE Lorenz, K AF Ahluwalia, Sangeeta Cromer, Risa Giannitrapani, Karleen Schreibeis-Baum, Hannah Dobscha, Steven Krebs, Erin E. Lorenz, Karl TI "IT ENCOURAGES THEM TO COMPLAIN": POTENTIAL UNINTENDED CONSEQUENCES OF ROUTINE PAIN SCREENING AND IMPLICATIONS FOR IMPROVEMENT SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Krebs, Erin E.] Minneapolis VA Hlth Care Syst, Minneapolis, MN USA. [Dobscha, Steven] Portland VA Med Ctr, Portland, OR USA. [Ahluwalia, Sangeeta] RAND Corp, Encino, CA USA. [Cromer, Risa] Vet Hlth Adm, Portland, OR USA. [Giannitrapani, Karleen; Schreibeis-Baum, Hannah; Lorenz, Karl] Vet Hlth Adm, Los Angeles, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2192233 BP S46 EP S46 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386900004 ER PT J AU Asch, DA Troxel, AB Stewart, WF Sequist, TD Jones, JB Hirsch, AG Hoffer, K Zhu, JS Wang, WL Hodlofski, AT Frasch, AB Weiner, MG Finnerty, DD Rosenthal, M Gangemi, K Volpp, KG AF Asch, David A. Troxel, Andrea B. Stewart, Walter F. Sequist, Thomas D. Jones, J. B. Hirsch, Annemarie G. Hoffer, Karen Zhu, Jingsan Wang, Wenli Hodlofski, Amanda T. Frasch, Antonette B. Weiner, Mark G. Finnerty, Darra D. Rosenthal, Meredith Gangemi, Kelsey Volpp, Kevin G. TI A MULTICENTER RANDOMIZED TRIAL OF PHYSICIAN, PATIENT, AND PHYSICIAN/PATIENT INCENTIVES TO IMPROVE LIPID MANAGEMENT SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Sequist, Thomas D.] Partners Healthcare Syst, Boston, MA 19104 USA. [Asch, David A.; Hoffer, Karen; Wang, Wenli; Frasch, Antonette B.; Finnerty, Darra D.] Univ Penn, Philadelphia, PA USA. [Troxel, Andrea B.; Zhu, Jingsan; Hodlofski, Amanda T.; Gangemi, Kelsey; Volpp, Kevin G.] Univ Penn, Philadelphia, PA 02115 USA. [Asch, David A.; Volpp, Kevin G.] Philadelphia VA Med Ctr, Philadelphia, PA USA. [Rosenthal, Meredith] Harvard Univ, Sch Publ Hlth, Boston, MA USA. [Stewart, Walter F.; Jones, J. B.] Sutter Hlth, San Francisco, CA USA. [Hirsch, Annemarie G.] Geisinger Hlth Syst, Danville, PA USA. [Weiner, Mark G.] Temple Univ Hlth Syst, Philadelphia, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2200183 BP S86 EP S86 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386900094 ER PT J AU Becker, W Tate, JP Edelman, EJ Gaither, J Akgun, K Barry, D Crystal, S Gordon, A Merlin, JS Kerns, RD Justice, AC Fiellin, DA AF Becker, William Tate, Janet P. Edelman, Eva J. Gaither, Julie Akgun, Kathleen Barry, Declan Crystal, Stephen Gordon, Adam Merlin, Jessica S. Kerns, Robert D. Justice, Amy C. Fiellin, David A. TI THE RELATIONSHIP AMONG OPIOID USE, HIV, AND ACCIDENTAL DEATH: IS IT IN THE EYE OF THE BEHOLDER? SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Gordon, Adam] Univ Pittsburgh, Pittsburgh, PA USA. [Gordon, Adam] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. [Becker, William; Akgun, Kathleen; Kerns, Robert D.] VA Connecticut, West Haven, CT USA. [Gaither, Julie; Barry, Declan] Yale Univ, New Haven, CT USA. [Crystal, Stephen] Rutgers State Univ, New Brunswick, NJ 08903 USA. [Merlin, Jessica S.] Univ Alabama Birmingham, Birmingham, AL USA. [Tate, Janet P.; Edelman, Eva J.; Justice, Amy C.; Fiellin, David A.] Yale Univ, Internal Med, New Haven, CT USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2198782 BP S74 EP S75 PG 2 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386900068 ER PT J AU Burke, RE Whitfield, E Coleman, EA Schwartz, R Ginde, AA Hittle, D AF Burke, Robert E. Whitfield, Emily Coleman, Eric A. Schwartz, Robert Ginde, Adit A. Hittle, David TI TIMING OF READMISSIONS FROM POST-ACUTE CARE: IMPLICATIONS FOR IMPROVING THE QUALITY OF TRANSITIONAL CARE SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Burke, Robert E.] Denver VA Med Ctr, Denver, CO USA. [Burke, Robert E.; Coleman, Eric A.; Schwartz, Robert; Hittle, David] Univ Colorado, Sch Med, Aurora, CO USA. [Ginde, Adit A.] Univ Colorado, Sch Med, Denver, CO USA. RI bebarta, vikhyat/K-3476-2015 NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2199110 BP S282 EP S283 PG 2 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386901142 ER PT J AU Carter, A Borrero, S Wessel, C Bean-Mayberry, B Washington, DL Corbelli, J AF Carter, Andrea Borrero, Sonya Wessel, Charles Bean-Mayberry, Bevanne Washington, Donna L. Corbelli, Jennifer TI RACIAL AND ETHNIC DISPARITIES IN HEALTHCARE AMONG WOMEN IN THE VA: A SYSTEMATIC REVIEW SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Carter, Andrea; Borrero, Sonya; Wessel, Charles; Corbelli, Jennifer] Univ Pittsburgh, Pittsburgh, PA USA. [Borrero, Sonya] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. [Bean-Mayberry, Bevanne; Washington, Donna L.] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. RI Wessel, Charles/B-2318-2013 OI Wessel, Charles/0000-0002-5018-0156 NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2194054 BP S241 EP S241 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386901053 ER PT J AU Centor, RM Atkinson, TP Waites, K Estrada, C AF Centor, Robert M. Atkinson, Thomas P. Waites, Ken Estrada, Carlos TI CENTOR SCORE PREDICTS COMMON BACTERIAL CAUSES OF SORE THROAT-NOT JUST GROUP A BETA HEMOLYTIC STREPTOCOCCUS SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Centor, Robert M.] Univ Alabama, Huntsville, AL 35899 USA. [Atkinson, Thomas P.; Waites, Ken; Estrada, Carlos] Univ Alabama Birmingham, Birmingham, AL USA. [Estrada, Carlos] Birmingham VAMC, Birmingham, AL USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2168431 BP S118 EP S118 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386900166 ER PT J AU Cordasco, KM Zuchowski, JL Hamilton, A Mark, C Bell-Lewis, L Chrystal, JG Kirsh, S Washington, DL AF Cordasco, Kristina M. Zuchowski, Jessica L. Hamilton, Alison Mark, Canning Bell-Lewis, LaShawnta Chrystal, Joya G. Kirsh, Susan Washington, Donna L. TI VETERANS HEALTH ADMINISTRATION ELECTRONIC CONSULTATIONS: WOMEN'S HEALTH PRIMARY CARE PROVIDERS' PERCEPTIONS SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Cordasco, Kristina M.; Zuchowski, Jessica L.; Hamilton, Alison; Mark, Canning; Bell-Lewis, LaShawnta; Chrystal, Joya G.; Washington, Donna L.] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. [Cordasco, Kristina M.; Hamilton, Alison; Washington, Donna L.] Univ Calif Los Angeles, Sch Med, Los Angeles, CA USA. [Kirsh, Susan] Cleveland VA Med Ctr, Cleveland, OH USA. [Kirsh, Susan] VA Cent Off, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2195043 BP S298 EP S298 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386901175 ER PT J AU Dailey, FE Burstein, S AF Dailey, Francis E. Burstein, Samuel TI AN ADULT WITH ATOMOXETINE-INDUCED HEPATITIS: A REPORT OF A RARE CASE SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Dailey, Francis E.] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA. [Burstein, Samuel] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2200271 BP S357 EP S357 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386901328 ER PT J AU Dulay, MH Bachhuber, M Shunk, RL OBrien, BC AF Dulay, Maya H. Bachhuber, Melissa Shunk, Rebecca L. OBrien, Bridget C. TI IMPROVING IDENTIFICATION OF HIGH-RISK PRIMARY CARE PATIENTS FOR INTERNAL MEDICINE RESIDENTS' YEAR-END HANDOFFS SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Dulay, Maya H.; Bachhuber, Melissa; Shunk, Rebecca L.] San Francisco VA Med Ctr, San Francisco, CA USA. [Dulay, Maya H.; Bachhuber, Melissa; Shunk, Rebecca L.; OBrien, Bridget C.] Univ Calif San Francisco, San Francisco, CA 94143 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2199524 BP S539 EP S539 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386902219 ER PT J AU Duru, OK Turk, N Ettner, S Moin, T Li, JN Keckhafer, AM Luchs, RH Chan, C Steers, N Mangione, C AF Duru, O. Kenrik Turk, Norman Ettner, Susan Moin, Tannaz Li, Jinnan Keckhafer, Abigail M. Luchs, Robert H. Chan, Charles Steers, Neil Mangione, Carol TI RESULTS FROM NEXT-D: PROMOTING BREAST CANCER SCREENING IN A DIABETES/PRE-DIABETES SPECIFIC HEALTH PLAN SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Duru, O. Kenrik; Turk, Norman; Ettner, Susan; Li, Jinnan; Steers, Neil; Mangione, Carol] Univ Calif Los Angeles, Los Angeles, CA USA. [Moin, Tannaz] Univ Calif Los Angeles, VA Greater Los Angeles, Los Angeles, CA USA. [Keckhafer, Abigail M.; Luchs, Robert H.; Chan, Charles] UnitedHealthcare, Minneapolis, MN USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2196155 BP S247 EP S247 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386901068 ER PT J AU Edelman, EJ Tate, JP Gordon, KS Becker, W Bryant, K Crothers, K Gaither, JR Gibert, C Gordon, A Marshall, BD Rodriguez-Barradas, M Samet, JH Skanderson, M Justice, AC Fiellin, DA AF Edelman, E. J. Tate, Janet P. Gordon, Kirsha S. Becker, William Bryant, Kendall Crothers, Kristina Gaither, J. R. Gibert, Cynthia Gordon, Adam Marshall, Brandon D. Rodriguez-Barradas, Maria Samet, Jeffrey H. Skanderson, Melissa Justice, Amy C. Fiellin, David A. TI DO PRESCRIBED OPIOIDS IMPACT CD4 COUNT RESTORATION AMONG HIV plus PATIENTS INITIATING ANTIRETROVIRAL THERAPY? SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Edelman, E. J.; Tate, Janet P.; Gordon, Kirsha S.; Becker, William; Justice, Amy C.; Fiellin, David A.] Yale Univ, Sch Med, New Haven, CT USA. [Becker, William; Justice, Amy C.] VA Connecticut Healthcare Syst, West Haven, CT USA. [Bryant, Kendall] NIH, Bethesda, MD 20892 USA. [Crothers, Kristina] Univ Washington, Seattle, WA 98195 USA. [Gaither, J. R.] Yale Univ, New Haven, CT USA. [Gibert, Cynthia] DC VAMC, Washington, DC USA. [Gibert, Cynthia] George Washington Univ, Washington, DC USA. [Gordon, Adam; Skanderson, Melissa] Univ Pittsburgh, Pittsburgh, PA USA. [Gordon, Adam; Skanderson, Melissa] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. [Marshall, Brandon D.] Brown Univ, Providence, RI 02912 USA. [Rodriguez-Barradas, Maria] Michael E DeBakey VAMC, Houston, TX USA. [Rodriguez-Barradas, Maria] Baylor Coll Med, Houston, TX 77030 USA. [Samet, Jeffrey H.] Boston Univ, Sch Med, Boston, MA 02118 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2199293 BP S142 EP S142 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386900221 ER PT J AU Edwards, ST Rubenstein, LV Meredith, LS Schmidt, N Stockdale, SE Cordasco, KM Lanto, A Roos, P Yano, EM AF Edwards, Samuel T. Rubenstein, Lisa V. Meredith, Lisa S. Schmidt, Nicole Stockdale, Susan E. Cordasco, Kristina M. Lanto, Andrew Roos, Philip Yano, Elizabeth M. TI WHO IS RESPONSIBLE FOR WHAT TASKS WITHIN PRIMARY CARE: PERCEIVED TASK ALLOCATION AMONG PRIMARY CARE PROVIDERS AND INTERDISCIPLINARY TEAM MEMBERS SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Rubenstein, Lisa V.; Stockdale, Susan E.; Lanto, Andrew; Yano, Elizabeth M.] Greater Los Angeles VA Healthcare Syst, Sepulveda, CA USA. [Meredith, Lisa S.; Schmidt, Nicole] RAND Corp, Santa Monica, CA USA. [Cordasco, Kristina M.] Univ Calif Los Angeles, VA Greater Los Angles Healthcare Syst, Los Angeles, CA USA. [Roos, Philip] VA Loma Linda Healthcare Syst, Loma Linda, CA USA. [Edwards, Samuel T.] VA Portland Hlth Care Syst, Portland, OR USA. [Edwards, Samuel T.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2185177 BP S303 EP S303 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386901186 ER PT J AU Giannitrapani, K Hamilton, A Huynh, AK Stockdale, SE Rubenstein, LV AF Giannitrapani, Karleen Hamilton, Alison Huynh, Alexis K. Stockdale, Susan E. Rubenstein, Lisa V. TI STAFF ROLES ON PRIMARY CARE TEAMS ARE FAILING TO ALIGN WITH PHYSICIANS' EXPECTATIONS AND NEEDS SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Rubenstein, Lisa V.] GLA VA, North Hills, CA USA. [Stockdale, Susan E.] Greater Los Angeles VA Healthcare Syst, Sepulveda, CA USA. [Giannitrapani, Karleen] UCLA VA GLA, Los Angeles, CA USA. [Hamilton, Alison] US Dept Vet Affairs, Los Angeles, CA USA. [Huynh, Alexis K.] Vet Affairs, Sepulveda, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2196596 BP S257 EP S257 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386901089 ER PT J AU Giannitrapani, K Ahluwalia, S Pisciotta, M Cromer, R Schreibeis-Baum, HC Dobscha, S Krebs, EE Lorenz, K AF Giannitrapani, Karleen Ahluwalia, Sangeeta Pisciotta, Maura Cromer, Risa Schreibeis-Baum, Hannah C. Dobscha, Steven Krebs, Erin E. Lorenz, Karl TI IMPROVING OPIOID PRESCRIBING IN THE CONTEXT OF ROUTINE PAIN SCREENING SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Krebs, Erin E.] Minneapolis VA Hlth Care Syst, Minneapolis, MN USA. [Pisciotta, Maura; Dobscha, Steven] Portland VA Med Ctr, Portland, OR USA. [Ahluwalia, Sangeeta] RAND Corp, Encino, CA USA. [Giannitrapani, Karleen] Univ Calif Los Angeles, VA GLA, Los Angeles, CA USA. [Schreibeis-Baum, Hannah C.] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. [Cromer, Risa] VA, Portland, OR USA. [Lorenz, Karl] Univ Calif Los Angeles, RAND, VA, Los Angeles, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2196337 BP S188 EP S188 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386900320 ER PT J AU Giannitrapani, K Huynh, AK Lanto, A Stockdale, SE Meredith, LS Rubenstein, LV AF Giannitrapani, Karleen Huynh, Alexis K. Lanto, Andrew Stockdale, Susan E. Meredith, Lisa S. Rubenstein, Lisa V. TI FACILITATORS OF TEAM FUNCTIONING DURING THE EARLY STAGES OF PCMH IMPLEMENTATION SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Rubenstein, Lisa V.] GLA VA, North Hills, CA USA. [Stockdale, Susan E.] Greater Los Angeles VA Healthcare Syst, Sepulveda, CA USA. [Meredith, Lisa S.] RAND Corp, Santa Monica, CA USA. [Giannitrapani, Karleen] UCLA VA GLA, Los Angeles, CA USA. [Lanto, Andrew] VA Greater LA Healthcare Syst, Sepulveda, CA USA. [Huynh, Alexis K.] Vet Affairs, Sepulveda, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2196640 BP S157 EP S157 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386900252 ER PT J AU Goldstein, KM Frayne, SM Gierisch, J Blakeney, J Yano, EM Sadler, A Bean-Mayberry, B Carney, D DiLeone, B Fox, A Klap, R Hamilton, A Yee, E Vogt, D AF Goldstein, Karen M. Frayne, Susan M. Gierisch, Jennifer Blakeney, Jill Yano, Elizabeth M. Sadler, Anne Bean-Mayberry, Bevanne Carney, Diane DiLeone, Brooke Fox, Annie Klap, Ruth Hamilton, Alison Yee, Ellen Vogt, Dawne TI EVIDENCE-BASED QUALITY IMPROVEMENT IN AVA WOMEN'S HEALTH PRACTICE BASED RESEARCH NETWORK SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Goldstein, Karen M.; Gierisch, Jennifer] Durham VA, Durham, NC USA. [Goldstein, Karen M.; Gierisch, Jennifer] Duke Univ, Durham, NC USA. [Yee, Ellen] NMVAHCS, Albuquerque, NM USA. [Hamilton, Alison] US Dept Vet Affairs, Los Angeles, CA USA. [Yano, Elizabeth M.; Bean-Mayberry, Bevanne; Klap, Ruth] VA Greater Los Angeles HSR&D Ctr, Sepulveda, CA USA. [Frayne, Susan M.; Carney, Diane] VA Palo Alto Hlth Care Syst, Menlo Pk, CA USA. [Frayne, Susan M.] Stanford Univ, Palo Alto, CA 94304 USA. [Yano, Elizabeth M.; Bean-Mayberry, Bevanne] Univ Calif Los Angeles, Los Angeles, CA USA. [Sadler, Anne] Dept Vet Affairs, Iowa City, IA USA. [Sadler, Anne] Univ Iowa, Iowa City, IA USA. [DiLeone, Brooke] Philadelphia VAMC, Philadelphia, PA USA. [Fox, Annie; Vogt, Dawne] VA Boston Med Ctr, Boston, MA USA. [Vogt, Dawne] Boston Univ, Boston, MA 02215 USA. [Blakeney, Jill] Durham VAMC, Durham, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2194776 BP S153 EP S153 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386900244 ER PT J AU Gopalan, A Cain, LR Makelarski, JA Garibay, LB Merchant, RM Lindau, ST AF Gopalan, Anjali Cain, Loretta R. Makelarski, Jennifer A. Garibay, Lori B. Merchant, Raina M. Lindau, Stacy T. TI HEALTH-SPECIFIC INFORMATION AND COMMUNICATION TECHNOLOGY USE AND ITS RELATIONSHIP TO CHRONIC DISEASE STATUS IN COMMUNITIES ON THE SOUTH SIDE OF CHICAGO SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Gopalan, Anjali] Philadelphia VA Med Ctr, Philadelphia, PA USA. [Gopalan, Anjali] Robert Wood Johnson Clin Scholars Program, Philadelphia, PA USA. [Merchant, Raina M.] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA. [Cain, Loretta R.; Makelarski, Jennifer A.; Lindau, Stacy T.] Univ Chicago, Chicago, IL 60637 USA. [Garibay, Lori B.] Rescue Social Change Grp, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2192280 BP S172 EP S172 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386900284 ER PT J AU Hamilton, AB Maisel, N Yano, EM Klap, R Oishi, S Balasubramanian, V Saechao, F Frayne, SM AF Hamilton, Alison B. Maisel, Natalya Yano, Elizabeth M. Klap, Ruth Oishi, Sabine Balasubramanian, Vidhya Saechao, Fay Frayne, Susan M. TI WOMEN VETERANS WITH CO-OCCURRING MENTAL HEALTH CONDITIONS IN VA PRIMARY CARE CLINICS: A MIXED METHODS STUDY SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Yano, Elizabeth M.] VA Greater Los Angeles HSR&D Ctr, Sepulveda, CA USA. [Hamilton, Alison B.; Klap, Ruth; Oishi, Sabine] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. [Frayne, Susan M.] VA Palo Alto Hlth Care Syst Stanford, Menlo Pk, CA USA. [Saechao, Fay] VAPAHCS, Menlo Pk, CA USA. [Maisel, Natalya; Balasubramanian, Vidhya] Vet Affairs Palo Alto Hlth Care Syst, Menlo Pk, CA USA. [Hamilton, Alison B.] Univ Calif Los Angeles, Los Angeles, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2197845 BP S305 EP S306 PG 2 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386901192 ER PT J AU Hoffman, R Shi, Y Freedland, S Keating, NL Walter, L AF Hoffman, Richard Shi, Ying Freedland, Stephen Keating, Nancy L. Walter, Louise TI TREATMENT PATTERNS FOR OLDER VETERANS WITH LOCALIZED PROSTATE CANCER SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Shi, Ying; Walter, Louise] San Francisco VA Med Ctr, San Francisco, CA USA. [Walter, Louise] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Hoffman, Richard] Albuquerque VA Med Ctr, Albuquerque, NM USA. [Hoffman, Richard] Univ New Mexico, Sch Med, Albuquerque, NM 87131 USA. [Freedland, Stephen] Duke Univ, Durham, NC USA. [Keating, Nancy L.] Harvard Univ, Sch Med, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2190732 BP S286 EP S287 PG 2 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386901151 ER PT J AU Howell, BA Long, J Edelman, EJ McGinnis, KA Rimland, D Fiellin, DA Justice, AC Wang, EA AF Howell, Benjamin A. Long, Jessica Edelman, E. J. McGinnis, Kathleen A. Rimland, David Fiellin, David A. Justice, Amy C. Wang, Emily A. TI LIFETIME AND RECENT INCARCERATION AND RISK OF UNCONTROLLED BLOOD PRESSURE CONTROL IN A MULTI-SITE COHORT SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Rimland, David] VA Med Ctr, Decatur, GA USA. [McGinnis, Kathleen A.] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. [Howell, Benjamin A.; Long, Jessica; Edelman, E. J.; Fiellin, David A.; Justice, Amy C.; Wang, Emily A.] Yale Univ, Sch Med, New Haven, CT USA. [Fiellin, David A.; Justice, Amy C.] Ctr Interdisciplinary Res AIDS, New Haven, CT USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2182563 BP S203 EP S203 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386900352 ER PT J AU Jones, CD Wald, H Boxer, RS Masoudi, FA Burke, RE Capp, R Ginde, AA AF Jones, Christine D. Wald, Heidi Boxer, Rebecca S. Masoudi, Frederick A. Burke, Robert E. Capp, Roberta Ginde, Adit A. TI REGIONAL VARIATION IN HOME HEALTH CARE REFERRALS AT HOSPITAL DISCHARGE: RESULTS FROM THE 2012 NATIONAL INPATIENT SAMPLE SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Burke, Robert E.] Denver VA Med Ctr, Denver, CO USA. [Jones, Christine D.] Univ Colorado, Aurora, CO USA. [Wald, Heidi; Boxer, Rebecca S.; Masoudi, Frederick A.; Capp, Roberta; Ginde, Adit A.] Univ Colorado, Denver, CO 80202 USA. RI bebarta, vikhyat/K-3476-2015 NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2197874 BP S245 EP S245 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386901063 ER PT J AU Kertesz, S Austin, EL Elam, C Johnson, N AF Kertesz, Stefan Austin, Erika L. Elam, Calvin Johnson, Nancy TI A SURVEY TO ASSESS PATIENT EXPERIENCES IN PATIENT-CENTERED MEDICAL HOMES FOR PATIENTS WHO ARE HOMELESS AND FORMERLY HOMELESS SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Kertesz, Stefan; Austin, Erika L.; Elam, Calvin; Johnson, Nancy] Birmingham VAMC, Birmingham, AL USA. [Kertesz, Stefan] Univ Alabama Birmingham, Birmingham, AL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2198318 BP S514 EP S515 PG 2 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386902170 ER PT J AU Kidwai-Khan, F McGinnis, KA Tate, JP Bryant, K Justice, AC AF Kidwai-Khan, Farah McGinnis, Kathleen A. Tate, Janet P. Bryant, Kendall Justice, Amy C. TI VACS-TLFB FOR ALCOHOL USE: A WEB BASED TIMELINE FOLLOWBACK APPLICATION - A HEALTH TECHNOLOGY ASSESSMENT SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [McGinnis, Kathleen A.] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. [Kidwai-Khan, Farah] Yale Univ, Sleepy Hollow, NY USA. [Justice, Amy C.] Yale Univ, West Haven, CT USA. [Tate, Janet P.] Yale Univ, SOM, West Haven, CT USA. [Kidwai-Khan, Farah; Bryant, Kendall] VA Connecticut Healthcare Syst, West Haven, CT USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2198915 BP S297 EP S297 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386901173 ER PT J AU Lebduska, E Kohli, A Hoffman, EL Fischer, G Spagnoletti, C Hariharan, J AF Lebduska, Elena Kohli, Amar Hoffman, Erika L. Fischer, Gary Spagnoletti, Carla Hariharan, Jaishree TI TEAM QI: AN INNOVATIVE STEPWISE APPROACH TO INVOLVE RESIDENTS IN QUALITY IMPROVEMENT INITIATIVES IN THE OUTPATIENT SETTING SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Kohli, Amar] UPMC, Pittsburgh, PA USA. [Fischer, Gary; Spagnoletti, Carla] Univ Pittsburgh, Pittsburgh, PA USA. [Lebduska, Elena; Hariharan, Jaishree] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA. [Hoffman, Erika L.] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2199104 BP S508 EP S509 PG 2 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386902155 ER PT J AU Moin, T Li, JN Duru, OK Ettner, S Turk, N Kimbro, L Keckhafer, AM Luchs, RH Ho, S Mangione, C AF Moin, Tannaz Li, Jinnan Duru, O. Kenrik Ettner, Susan Turk, Norman Kimbro, Lindsay Keckhafer, Abigail M. Luchs, Robert H. Ho, Sam Mangione, Carol TI RESULTS FROM NEXT-D: DOES A DISEASE SPECIFIC HEALTH PLAN REDUCE INCIDENT DIABETES DEVELOPMENT AMONG A NATIONAL SAMPLE OF WORKING-AGE ADULTS WITH PRE-DIABETES? SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Moin, Tannaz; Mangione, Carol] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA. [Li, Jinnan; Duru, O. Kenrik; Ettner, Susan; Turk, Norman; Kimbro, Lindsay] Univ Calif Los Angeles, Los Angeles, CA USA. [Moin, Tannaz] VA Greater Los Angeles, Los Angeles, CA USA. [Keckhafer, Abigail M.; Luchs, Robert H.; Ho, Sam] UnitedHealthCare, Minneapolis, MN USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2198946 BP S246 EP S247 PG 2 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386901067 ER PT J AU Mortensen, E Bollinger, M Fine, M AF Mortensen, Eric Bollinger, Mary Fine, MIchael TI ELECTRONIC MEDICAL RECORD BASED INTERVENTION TO REDUCE LENGTH OF STAY FOR VETERANS HOSPITALIZED WITH PNEUMONIA SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Mortensen, Eric] VANTHCS, Dallas, TX USA. [Mortensen, Eric] UT Southwestern Med Ctr, Dallas, TX USA. [Bollinger, Mary] STVHCS, San Antonio, TX USA. [Fine, MIchael] VA Pittsburgh Hlth Care Syst, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2194967 BP S56 EP S56 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386900028 ER PT J AU Nelson, KM Schwartz, GJ Hernandez, S Simonetti, JA Curtis, I Fihn, SD AF Nelson, Karin M. Schwartz, Gregory J. Hernandez, Susan Simonetti, Joseph A. Curtis, Idamay Fihn, Stephan D. TI THE ASSOCIATION OF NEIGHBORHOOD ENVIRONMENT AND MORTALITY: RESULTS FROM A NATIONAL STUDY OF VETERANS SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Nelson, Karin M.; Simonetti, Joseph A.; Fihn, Stephan D.] Univ Washington, VA Puget Sound, Seattle, WA 98195 USA. [Schwartz, Gregory J.; Hernandez, Susan; Simonetti, Joseph A.] VA, Seattle, WA USA. [Curtis, Idamay; Fihn, Stephan D.] Vet Hlth Adm, Seattle, WA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2198108 BP S267 EP S267 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386901107 ER PT J AU Nelson, KM Sylling, PW Wong, E Taylor, L Helfrich, CD Curtis, I Schectman, G Stark, R Fihn, SD AF Nelson, Karin M. Sylling, Philip W. Wong, Edwin Taylor, Leslie Helfrich, Christian D. Curtis, Idamay Schectman, Gordon Stark, Richard Fihn, Stephan D. TI IMPLEMENTATION OF THE PATIENT CENTERED MEDICAL HOME (PCMH) IN THE VETERANS HEALTH ADMINISTRATION (VHA): ASSOCIATIONS WITH CLINICAL OUTCOMES, PATIENT SATISFACTION, PROVIDER BURNOUT AND HEALTH CARE USE SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Stark, Richard] Dept Vet Affairs, Washington, DC USA. [Wong, Edwin] Northwest Ctr Outcomes Res Older Adults, Seattle, WA USA. [Nelson, Karin M.] Univ Washington, VA Puget Sound, Seattle, WA 98195 USA. [Nelson, Karin M.; Taylor, Leslie] VA, Seattle, WA USA. [Helfrich, Christian D.] VA Puget Sound Healthcare Syst, Seattle, WA USA. [Schectman, Gordon] Vet Affairs Cent Off, Milwaukee, WI USA. [Sylling, Philip W.; Curtis, Idamay; Fihn, Stephan D.] Vet Hlth Adm, Seattle, WA USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2198377 BP S185 EP S185 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386900313 ER PT J AU Nikiforova, T Benson, MK Hamm, M Williams, K Zickmund, SL Donovan, AK AF Nikiforova, Tanya Benson, Maggie K. Hamm, Megan Williams, Kelly Zickmund, Susan L. Donovan, Anna K. TI FITTING THE BILL: A QUALITATIVE ANALYSIS OF GROUP REFLECTIONS ON PATIENTS' HOSPITAL CHARGES SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Nikiforova, Tanya; Benson, Maggie K.; Donovan, Anna K.] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA. [Zickmund, Susan L.] Univ Pittsburgh, VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. [Hamm, Megan; Williams, Kelly] Univ Pittsburgh, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2198694 BP S496 EP S496 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386902127 ER PT J AU Patel, M Asch, DA Troxel, AB Wesby, L Ulrich, V Zhu, JS Wang, WL Volpp, KG AF Patel, Mitesh Asch, David A. Troxel, Andrea B. Wesby, Lisa Ulrich, Victoria Zhu, Jingsan Wang, Wenli Volpp, Kevin G. TI WORKPLACE WELLNESS INCENTIVES FOR WEIGHT LOSS-A RANDOMIZED, CONTROLLED TRIAL SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Patel, Mitesh; Asch, David A.; Troxel, Andrea B.; Wesby, Lisa; Ulrich, Victoria; Zhu, Jingsan; Wang, Wenli; Volpp, Kevin G.] Univ Penn, Philadelphia, PA 19104 USA. [Patel, Mitesh; Asch, David A.; Volpp, Kevin G.] Philadelphia VA Med Ctr, Philadelphia, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2196639 BP S306 EP S307 PG 2 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386901195 ER PT J AU Patel, M Reed, D Smith, CD Arora, VM AF Patel, Mitesh Reed, Darcy Smith, Cynthia D. Arora, Vineet M. TI ROLE-MODELING COST-CONSCIOUS CARE-A NATIONAL EVALUATION OF FACULTY AT TEACHING HOSPITALS IN THE UNITED STATES SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Reed, Darcy] Mayo Clin, Rochester, MN USA. [Arora, Vineet M.] Univ Chicago, Med Ctr, Chicago, IL 60637 USA. [Patel, Mitesh] Univ Penn, Philadelphia, PA 19104 USA. [Patel, Mitesh] Philadelphia VA Med Ctr, Philadelphia, PA USA. [Smith, Cynthia D.] Amer Coll Physicians, Philadelphia, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2196655 BP S249 EP S249 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386901073 ER PT J AU Pierce, C Ozzello, D Keniston, A Stickrath, C Health, D AF Pierce, Cason Ozzello, Daniel Keniston, Angela Stickrath, Chad Health, Denver TI THE FREQUENCY OF ATTENDING-LED DISCUSSION OF TEST ORDERING PRINCIPLES DURING INTERNAL MEDICINE WARDS ROUNDS SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Pierce, Cason] Denver Hlth, Denver, CO USA. [Keniston, Angela] Denver Hlth & Hosp Author, Denver, CO USA. [Stickrath, Chad] Denver VA Med Ctr, Denver, CO USA. [Pierce, Cason; Ozzello, Daniel] Univ Colorado, Denver, CO 80202 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2197468 BP S272 EP S273 PG 2 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386901121 ER PT J AU Primack, BA Shensa, A Sidani, J Colditz, J Brook, J Fine, MJ AF Primack, Brian A. Shensa, Ariel Sidani, Jaime Colditz, Jason Brook, Judith Fine, Michael J. TI WATERPIPE TOBACCO SMOKING AMONG US YOUNG ADULTS BOTH IN AND NOT IN SCHOOL: A NATIONALLY-REPRESENTATIVE STUDY SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Primack, Brian A.; Shensa, Ariel; Sidani, Jaime; Colditz, Jason] Univ Pittsburgh, Pittsburgh, PA USA. [Fine, Michael J.] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. [Brook, Judith] NYU, New York, NY USA. NR 0 TC 0 Z9 0 U1 1 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2197948 BP S299 EP S300 PG 2 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386901179 ER PT J AU Primack, BA Carroll, M Weiss, PM Shihadeh, A Shensa, A Farley, S Fine, MJ Eissenberg, T Nayak, S AF Primack, Brian A. Carroll, Mary Weiss, Patricia M. Shihadeh, Alan Shensa, Ariel Farley, Steven Fine, Michael J. Eissenberg, Thomas Nayak, Smita TI SYSTEMATIC REVIEW AND META-ANALYSIS OF INHALED TOXICANTS FROM WATERPIPE AND CIGARETTE SMOKING SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Primack, Brian A.; Weiss, Patricia M.; Shensa, Ariel; Farley, Steven] Univ Pittsburgh, Pittsburgh, PA USA. [Fine, Michael J.] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. [Carroll, Mary] Squirrel Hill Hlth Ctr, Pittsburgh, PA USA. [Shihadeh, Alan] Amer Univ Beirut, Beirut, Lebanon. [Nayak, Smita] Swedish Ctr Res & Innovat, Seattle, WA USA. [Eissenberg, Thomas] Virginia Commonwealth Univ, Richmond, VA USA. NR 0 TC 0 Z9 0 U1 2 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2198875 BP S262 EP S262 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386901098 ER PT J AU Primack, BA Soneji, S Stoolmiller, M Fine, MJ Sargent, J AF Primack, Brian A. Soneji, Samir Stoolmiller, Michael Fine, Michael J. Sargent, Jim TI INITIATION OF CIGARETTE SMOKING AFTER ELECTRONIC CIGARETTE USE: A NATIONAL STUDY OF YOUNG ADULTS SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Primack, Brian A.] Univ Pittsburgh, Pittsburgh, PA USA. [Fine, Michael J.] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. [Soneji, Samir; Sargent, Jim] Dartmouth Coll, Sch Med, Hanover, NH USA. [Stoolmiller, Michael] Oregon Social Learning Ctr, Eugene, OR 97401 USA. NR 0 TC 0 Z9 0 U1 2 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2198326 BP S193 EP S193 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386900331 ER PT J AU Quinones, A Joos, S Hart, KD Rosales, A Perrin, N Kansagara, D AF Quinones, Ana Joos, Sandra Hart, Kyle D. Rosales, Ana Perrin, Nancy Kansagara, Devan TI THE EFFECTS OF IMPLEMENTING A PATIENT-CENTERED MEDICAL HOME MODEL ON EMERGENCY UTILIZATION IN A VA HEALTH CARE SETTING SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Quinones, Ana; Hart, Kyle D.; Kansagara, Devan] OHSU, Portland, OR USA. [Joos, Sandra] Portland VA Med Ctr, Portland, OR USA. [Kansagara, Devan] VA Portland Hlth Care Syst, Portland, OR USA. [Rosales, Ana; Perrin, Nancy] Kaiser Permanente Ctr Hlth Res, Portland, OR USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2201320 BP S271 EP S272 PG 2 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386901119 ER PT J AU Radomski, TR Zhao, XH Thorpe, CT Good, C Mor, M Fine, MJ Gellad, WF AF Radomski, Thomas R. Zhao, Xinhua Thorpe, Carolyn T. Good, Chester Mor, Maria Fine, Michael J. Gellad, Walid F. TI TYPOLOGIES OF VA AND MEDICARE UTILIZATION AMONG DUALLY ENROLLED VETERANS WITH TYPE 2 DIABETES: A LATENT CLASS ANALYSIS SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Thorpe, Carolyn T.; Mor, Maria] Univ Pittsburgh, Pittsburgh, PA USA. [Radomski, Thomas R.; Zhao, Xinhua; Thorpe, Carolyn T.; Good, Chester; Mor, Maria; Fine, Michael J.] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. [Gellad, Walid F.] Univ Pittsburgh, VA Pittsburgh, Pittsburgh, PA USA. [Radomski, Thomas R.; Good, Chester; Fine, Michael J.] Univ Pittsburgh, Sch Med, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2196785 BP S290 EP S291 PG 2 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386901159 ER PT J AU Ramsey, AL Otazo, M Caruso, A Bates, JT AF Ramsey, Allison L. Otazo, Maria Caruso, Andrew Bates, Jeffrey T. TI PRIMARILY SUSPECT CHOLANGIOCARCINOMA SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Ramsey, Allison L.; Otazo, Maria; Caruso, Andrew] Baylor Coll Med, Houston, TX 77030 USA. [Bates, Jeffrey T.] VA Med Ctr, Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2200185 BP S439 EP S440 PG 2 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386901547 ER PT J AU Ray, L Zingmond, D Vangala, S Sayles, JN Tu, M Chu, LH Pollack, BA Malloy, D Saliba, D AF Ray, Lhasa Zingmond, David Vangala, Sitaram Sayles, Jennifer N. Tu, Michael Chu, Li-Hao Pollack, Bruce A. Malloy, Demetria Saliba, Debra TI AN EVALUATION OF THE IMPACT OF CALIFORNIA'S TRANSITION TO MANAGED CARE ON HEALTH CARE UTILIZATION BY MEDICAID SENIORS AND PERSONS WITH DISABILITIES SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Zingmond, David] Univ Calif Los Angeles, Los Angeles, CA USA. [Saliba, Debra] Univ Calif Los Angeles, Borun Ctr, VA GRECC, RAND, Los Angeles, CA USA. [Ray, Lhasa; Vangala, Sitaram] Univ Calif Los Angeles, Culver City, CA USA. [Ray, Lhasa; Zingmond, David; Saliba, Debra] Vet Affairs Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. [Sayles, Jennifer N.] Los Angeles Cty, Los Angeles, CA USA. [Tu, Michael; Chu, Li-Hao; Pollack, Bruce A.; Malloy, Demetria] LA Care Hlth Plan, Los Angeles, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2193338 BP S99 EP S100 PG 2 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386900128 ER PT J AU Rosland, AM Wong, E Zulman, DM Piegari, RI Prenovost, K Fihn, SD Nelson, KM AF Rosland, Ann-Marie Wong, Edwin Zulman, Donna M. Piegari, Rebecca I. Prenovost, Katherine Fihn, Stephan D. Nelson, Karin M. TI HIGHER LEVEL OF PATIENT-CENTERED MEDICAL HOME IMPLEMENTATION ASSOCIATED WITH IMPROVEMENTS IN CLINICAL QUALITY OF CARE IN THE NATION-WIDE VHA PACT INITIATIVE SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Wong, Edwin; Nelson, Karin M.] Northwest Ctr Outcomes Res Older Adults, Seattle, WA USA. [Nelson, Karin M.] Univ Washington, VA Puget Sound, Seattle, WA 98195 USA. [Rosland, Ann-Marie; Prenovost, Katherine] VA Ann Arbor, Ann Arbor, MI USA. [Piegari, Rebecca I.; Fihn, Stephan D.] Dept Vet Affairs, Seattle, WA USA. [Rosland, Ann-Marie] Univ Michigan, Sch Med, Ann Arbor, MI USA. [Zulman, Donna M.] VA Palo Alto, Palo Alto, CA USA. [Zulman, Donna M.] Stanford Univ, Palo Alto, CA 94304 USA. RI Rosland, Annmarie/B-7750-2016 NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2198149 BP S175 EP S176 PG 2 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386900292 ER PT J AU Ryskina, KL Holmboe, E Bernabeo, EC Kim, EJ Shea, JA Long, J AF Ryskina, Kira L. Holmboe, Eric Bernabeo, Elizabeth C. Kim, Esther J. Shea, Judy A. Long, Judith TI PHYSICIAN AWARENESS AND USE OF OVERTREATMENT GUIDELINES IN PRACTICE: A NATIONAL SURVEY OF US INTERNISTS SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Holmboe, Eric] ACGME, Philadelphia, PA USA. [Bernabeo, Elizabeth C.] Amer Board Internal Med, Philadelphia, PA USA. [Long, Judith] Philadelphia VA Ctr Hlth Equ Res & Promot, Philadelphia, PA USA. [Ryskina, Kira L.; Kim, Esther J.; Shea, Judy A.] Univ Penn, Philadelphia, PA 19104 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2199369 BP S228 EP S228 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386901022 ER PT J AU Silverman, JB Nelson, KM Krieger, J AF Silverman, Julie B. Nelson, Karin M. Krieger, James TI INCORPORATING COMMUNITY HEALTH WORKERS INTO THE VA: WHAT DO VETERANS THINK? SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Nelson, Karin M.] Univ Washington, VA Puget Sound, Seattle, WA 98195 USA. [Silverman, Julie B.] VA Puget Sound, Seattle, WA USA. [Krieger, James] Publ Hlth Seattle King Cty, Seattle, WA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2191031 BP S191 EP S191 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386900326 ER PT J AU Silverman, JB Krieger, J Nelson, KM AF Silverman, Julie B. Krieger, Jim Nelson, Karin M. TI A LOOK INSIDE COMMUNITY HEALTH WORKERS' VISITS: A QUALITATIVE STUDY SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Nelson, Karin M.] Univ Washington, VA Puget Sound, Seattle, WA 98195 USA. [Silverman, Julie B.] VA Puget Sound, Seattle, WA USA. [Krieger, Jim] Act Hlth Food, Seattle, WA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2198635 BP S85 EP S86 PG 2 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386900093 ER PT J AU Spataro, B Tulsky, A Comer, D Rubio, D Spagnoletti, C AF Spataro, Brielle Tulsky, Asher Comer, Diane Rubio, Doris Spagnoletti, Carla TI BRIDGING THE GAP: A POST HOSPITAL DISCHARGE VISIT CURRICULUM SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Spataro, Brielle] UPMC Presbyterian Hosp, Pittsburgh, PA USA. [Tulsky, Asher; Comer, Diane; Rubio, Doris; Spagnoletti, Carla] Univ Pittsburgh, Pittsburgh, PA USA. [Spataro, Brielle] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2193329 BP S488 EP S489 PG 2 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386902109 ER PT J AU Walling, A Ahluwalia, S Wenger, N Smith, P Booth, M Roth, C Lorenz, K Kanwal, F Dy, SM Asch, S AF Walling, Anne Ahluwalia, Sangeeta Wenger, Neil Smith, Patty Booth, Marika Roth, Carol Lorenz, Karl Kanwal, Fasiha Dy, Sydney M. Asch, Steven TI PALLIATIVE CARE QUALITY INDICATORS FOR PATIENTS WITH END STAGE LIVER DISEASE SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Dy, Sydney M.] Johns HOpkins, Baltimore, MD USA. [Ahluwalia, Sangeeta; Smith, Patty; Booth, Marika; Roth, Carol] RAND Corp, Encino, CA USA. [Wenger, Neil] Univ Calif Los Angeles, Los Angeles, CA USA. [Walling, Anne] Univ Calif Los Angeles, Studio City, CA USA. [Asch, Steven] VA, Menlo Pk, CA USA. [Lorenz, Karl] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. [Kanwal, Fasiha] Houston VA, Houston, TX USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2196734 BP S219 EP S219 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386900387 ER PT J AU Warde, C Ching, WT Sohmer, R AF Warde, Carole Ching, Wendell T. Sohmer, Robin TI ENHANCING RESILIENCE TO PROMOTE VA PATIENT-CENTERED MEDICAL HOME TRANSFORMATION AND THE UNTOWARD EFFECTS OF THE NATIONAL ACCESS CRISIS SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Warde, Carole] Greater Los Angeles VA Hlth Syst, North Hills, CA USA. [Ching, Wendell T.; Sohmer, Robin] VA Sepulveda Amb Care Ctr, North Hills, CA USA. [Warde, Carole; Ching, Wendell T.] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2194553 BP S516 EP S516 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386902173 ER PT J AU Washington, DL Hamilton, AB Cordasco, KM AF Washington, Donna L. Hamilton, Alison B. Cordasco, Kristina M. TI VULNERABILITY FOR HEALTHCARE COMMUNICATION GAPS FOR USERS OF VA PURCHASED CARE: IMPLICATIONS FOR THE VETERANS CHOICE ACT SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Washington, Donna L.; Hamilton, Alison B.; Cordasco, Kristina M.] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. [Washington, Donna L.; Hamilton, Alison B.; Cordasco, Kristina M.] Univ Calif Los Angeles, Sch Med, Los Angeles, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2198688 BP S80 EP S80 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386900079 ER PT J AU Young, EA Stickrath, C Calderon, A Chapman, E Gonzalo, J Kuperman, E Lopez, M Smith, CJ Sweigart, JR Theobald, C Burke, RE AF Young, Eric A. Stickrath, Chad Calderon, Aaron Chapman, Elizabeth Gonzalo, Jed Kuperman, Ethan Lopez, Max Smith, Christopher J. Sweigart, Joseph R. Theobald, Cecilia Burke, Robert E. TI INTERNAL MEDICINE RESIDENTS' PERCEIVED RESPONSIBILITY FOR TRANSITIONS OF CARE: A NEEDS ASSESSMENT SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Young, Eric A.; Stickrath, Chad; Burke, Robert E.] Denver VA Med Ctr, Denver, CO USA. [Gonzalo, Jed] Penn State Coll Med, Hershey, PA USA. [Kuperman, Ethan] Univ Iowa, Carver Coll Med, Iowa City, IA USA. [Smith, Christopher J.] Univ Nebraska Med Ctr, Omaha, NE USA. [Chapman, Elizabeth] Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI USA. [Young, Eric A.; Stickrath, Chad; Burke, Robert E.] Univ Colorado, Sch Med, Aurora, CO USA. [Calderon, Aaron] St Joseph Med Ctr, Denver, CO USA. [Lopez, Max] Univ Vermont, Burlington, VT USA. [Sweigart, Joseph R.] Univ Kentucky, Lexington, KY USA. [Theobald, Cecilia] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2196402 BP S195 EP S196 PG 2 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386900336 ER PT J AU Zuchowski, JL Cordasco, KM Oishi, SM Rose, D Canelo, I Yano, EM Hamilton, A AF Zuchowski, Jessica L. Cordasco, Kristina M. Oishi, Sabine M. Rose, Danielle Canelo, Ismelda Yano, Elizabeth M. Hamilton, Alison TI THE USE OF TELE-MENTAL HEALTH TO ADDRESS WOMEN VETERANS' MENTAL HEALTH NEEDS IN VA SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Zuchowski, Jessica L.; Cordasco, Kristina M.; Oishi, Sabine M.; Rose, Danielle; Canelo, Ismelda; Yano, Elizabeth M.; Hamilton, Alison] US Dept Vet Affairs, North Hills, CA USA. [Cordasco, Kristina M.] Univ Calif Los Angeles, VA Greater Los Angles Healthcare Syst, Los Angeles, CA USA. [Yano, Elizabeth M.; Hamilton, Alison] Univ Calif Los Angeles, Los Angeles, CA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2196274 BP S281 EP S282 PG 2 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386901141 ER PT J AU Zuchowski, JL Huynh, AK Stockdale, SE Meredith, LS Robles, AE Roos, P Rubenstein, LV Cordasco, KM AF Zuchowski, Jessica L. Huynh, Alexis K. Stockdale, Susan E. Meredith, Lisa S. Robles, Antonio E. Roos, Philip Rubenstein, Lisa V. Cordasco, Kristina M. TI SPECIALIST AWARENESS OF THE VA PATIENT-CENTERED MEDICAL HOME SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 38th Annual Meeting of the Society-of-General-Internal-Medicine (SGIM) CY APR 22-25, 2015 CL Toronto, CANADA SP Soc Gen Internal Med C1 [Rubenstein, Lisa V.] GLA VA, North Hills, CA USA. [Meredith, Lisa S.; Rubenstein, Lisa V.] RAND Corp, Santa Monica, CA USA. [Zuchowski, Jessica L.; Huynh, Alexis K.; Stockdale, Susan E.; Cordasco, Kristina M.] US Dept Vet Affairs, North Hills, CA USA. [Cordasco, Kristina M.] Univ Calif Los Angeles, VA Greater Los Angles Healthcare Syst, Los Angeles, CA USA. [Robles, Antonio E.; Roos, Philip] VA Loma Linda Healthcare Syst, Loma Linda, CA USA. [Robles, Antonio E.; Roos, Philip] Loma Linda Univ, Loma Linda, CA 92350 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 SU 2 MA 2196239 BP S254 EP S255 PG 2 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN4FV UT WOS:000358386901085 ER PT J AU Ibrahim, SA AF Ibrahim, Said A. TI Patient Preference as a Barrier to Needed Care SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material ID JOINT REPLACEMENT; WILLINGNESS C1 [Ibrahim, Said A.] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA. [Ibrahim, Said A.] Dept Vet Affairs VA, Ctr Hlth Equ Res & Promot, Philadelphia, PA USA. RP Ibrahim, SA (reprint author), Univ Penn, Perelman Sch Med, Ctr Hlth Equ Res & Promot, Philadelphia VA Med Ctr ANNEX,Med, 3900 Woodland Ave, Philadelphia, PA 19104 USA. EM said.ibrahim2@va.gov FU National Institutes of Musculoskeletal and Skin Disorders [1K24AR055259-01] FX S. A. Ibrahim is supported by the National Institutes of Musculoskeletal and Skin Disorders (award 1K24AR055259-01). NR 6 TC 0 Z9 0 U1 0 U2 0 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD APR PY 2015 VL 105 IS 4 BP 613 EP 614 DI 10.2105/AJPH.2015.302603 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CM0SE UT WOS:000357387800023 PM 25713949 ER PT J AU Hawkins, M Newman, AB Madero, M Patel, KV Shlipak, MG Cooper, J Johansen, KL Navaneethan, SD Shorr, RI Simonsick, EM Fried, LF AF Hawkins, Marquis Newman, Anne B. Madero, Magdalena Patel, Kushang V. Shlipak, Michael G. Cooper, Jennifer Johansen, Kirsten L. Navaneethan, Sankar D. Shorr, Ronald I. Simonsick, Eleanor M. Fried, Linda F. TI TV Watching, but Not Physical Activity, Is Associated With Change in Kidney Function in Older Adults SO JOURNAL OF PHYSICAL ACTIVITY & HEALTH LA English DT Article DE sedentary lifestyle; chronic disease; aged; renal health ID SERUM CYSTATIN-C; BODY-COMPOSITION; ESTIMATING GFR; SITTING TIME; HEALTH ABC; DISEASE; RISK; CKD; OBESITY; LIFE AB Background: Physical activity (PA) may play a role in preserving kidney health. The purpose of this study was to determine if PA and sedentary behavior are associated with incident chronic kidney disease (CKD) and change in kidney function in older adults. Methods: The Health, Aging, and Body Composition study is a prospective cohort of 3075 well-functioning older adults. PA and television watching was measured by self-report, and serum cystatin C was used to estimate glomerular filtration rate (eGFR). CKD was defined as an eGFR <60 ml/min/1.73m(2). Rapid kidney function decline was defined as an annual loss in eGFR of >3ml/min/1.73m(2). Discrete survival analysis was used to determine if baseline PA and television watching were related to 10-year cumulative incidence of CKD and rapid decline in kidney function. Results: Individuals who reported watching television >3 hours/day had a higher risk of incident CKD (HR 1.34; 95% CI, 1.09-1.65) and experiencing a rapid decline in kidney function (HR 1.26; 95% CI, 1.05-1.52) compared with individuals who watched television <2 hours/day. PA was not related to either outcome. Conclusions: High levels of television watching are associated with declining kidney function; the mechanisms that underlie this association need further study. C1 [Hawkins, Marquis; Fried, Linda F.] Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Div Biostat & Epidemiol, Amherst, MA 01003 USA. [Fried, Linda F.] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. [Newman, Anne B.; Cooper, Jennifer] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA. [Madero, Magdalena] Inst Nacl Cardiol Ignacio Chavez, Mexico City, DF, Mexico. [Patel, Kushang V.] Univ Washington, Dept Anesthesiol & Pain Med, Seattle, WA 98195 USA. [Shlipak, Michael G.; Johansen, Kirsten L.] San Francisco VA, San Francisco, CA USA. [Shlipak, Michael G.; Johansen, Kirsten L.] Univ Calif San Francisco, Dept Med, San Francisco, CA USA. [Navaneethan, Sankar D.] Cleveland Clin, Dept Hypertens & Nephrol, Cleveland, OH 44106 USA. [Shorr, Ronald I.] Univ Florida, Dept Epidemiol, Gainseville, FL USA. [Simonsick, Eleanor M.] NIA, Baltimore, MD 21224 USA. RP Hawkins, M (reprint author), Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Div Biostat & Epidemiol, Amherst, MA 01003 USA. EM mshawkins@schoolph.umass.edu OI Newman, Anne B./0000-0002-0106-1150 FU National Institute on Aging (NIA) [N01-AG-6-2101, N01-AG-6-2103, N01-AG-6-2106]; NIA [R01-AG028050, R01-AG029364]; NINR [R01-NR012459]; Intramural Research Program of the National Institutes of Health, National Institute on Aging FX This research was supported by National Institute on Aging (NIA) Contracts N01-AG-6-2101, N01-AG-6-2103, and N01-AG-6-2106; NIA Grant R01-AG028050, NIA Grant R01-AG029364, NINR Grant R01-NR012459, and the Intramural Research Program of the National Institutes of Health, National Institute on Aging. NR 33 TC 0 Z9 0 U1 3 U2 6 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1543-3080 EI 1543-5474 J9 J PHYS ACT HEALTH JI J. Phys. Act. Health PD APR PY 2015 VL 12 IS 4 BP 561 EP 568 DI 10.1123/jpah.2013-0289 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CM7XE UT WOS:000357909000018 PM 24762526 ER PT J AU McNeil, MR Pratt, SR Szuminsky, N Sung, JE Fossett, TRD Fassbinder, W Lim, KY AF McNeil, Malcolm R. Pratt, Sheila R. Szuminsky, Neil Sung, Jee Eun Fossett, Tepanta R. D. Fassbinder, Wiltrud Lim, Kyoung Yuel TI Reliability and Validity of the Computerized Revised Token Test: Comparison of Reading and Listening Versions in Persons With and Without Aphasia SO JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH LA English DT Article ID SPEEDED CLASSIFICATION; VISUAL DOMINANCE; COMPREHENSION; IMPAIRMENTS; INDIVIDUALS; PERFORMANCE; MODALITY; STIMULUS; SPEECH; PEOPLE AB Purpose: This study assessed the reliability and validity of intermodality associations and differences in persons with aphasia (PWA) and healthy controls (HC) on a computerized listening and 3 reading versions of the Revised Token Test (RTT; McNeil & Prescott, 1978). Method: Thirty PWA and 30 HC completed the test versions, including a complete replication. Reading versions varied according to stimulus presentation method: (a) full-sentence presentation, (b) self-paced word-by-word fullsentence construction, and (c) self-paced word-by-word presentation with each word removed with the onset of the next word. Participants also received tests of aphasia and reading severity. Results: The listening version produced higher overall mean scores than each of the reading versions. Differences were small and within 1 standard error of measurement of each version. Overall score test-retest reliability among versions for PWA ranged from r =.89 to r = .97. Correlations between the listening and reading versions ranged from r = .79 to r = .85. All versions correlated highly with aphasia and reading severity. Correlations were generally low for the HC due to restricted variability. Factor analysis yielded a 2-factor solution for PWA and a single-factor for HC. Conclusions: Intermodality differences were small, and all 4 versions were reliable, concurrently valid, and sensitive to similar linguistic processing difficulties in PWA. C1 [McNeil, Malcolm R.; Pratt, Sheila R.; Szuminsky, Neil; Sung, Jee Eun; Fossett, Tepanta R. D.; Fassbinder, Wiltrud; Lim, Kyoung Yuel] VA Pittsburgh Healthcare Syst, Geriatr Res Educ & Clin Ctr, Pittsburgh, PA USA. [McNeil, Malcolm R.; Pratt, Sheila R.; Szuminsky, Neil; Sung, Jee Eun; Fossett, Tepanta R. D.; Fassbinder, Wiltrud; Lim, Kyoung Yuel] Univ Pittsburgh, Pittsburgh, PA 15260 USA. RP McNeil, MR (reprint author), VA Pittsburgh Healthcare Syst, Geriatr Res Educ & Clin Ctr, Pittsburgh, PA USA. EM mcneil@pitt.edu FU VA Hospital, Denver, CO; Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Rehabilitation Research and Development Service [C47074X, C3118R] FX The previously published test on which this research is based is derived from McNeil and Prescott (1978), and those data are based on work supported in part by the VA Hospital, Denver, CO. Additional support for the work reported here are based in part on funding supplied by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Rehabilitation Research and Development Service (award #C47074X to Malcolm R. McNeil and award #C3118R to Patrick J. Doyle and Sheila R. Pratt), and resources and facilities provided by the Geriatric Research Education and Clinical Center in the Veterans Affairs Pittsburgh Healthcare System, PA. The contents of this article do not represent the views of the Department of Veterans Affairs or the U.S. Government. NR 46 TC 2 Z9 2 U1 2 U2 7 PU AMER SPEECH-LANGUAGE-HEARING ASSOC PI ROCKVILLE PA 10801 ROCKVILLE PIKE, ROCKVILLE, MD 20852-3279 USA SN 1092-4388 EI 1558-9102 J9 J SPEECH LANG HEAR R JI J. Speech Lang. Hear. Res. PD APR PY 2015 VL 58 IS 2 BP 311 EP 324 DI 10.1044/2015_JSLHR-L-13-0030 PG 14 WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation GA CL6ZF UT WOS:000357118000012 PM 25569547 ER PT J AU Molis, MR Kampel, SD McMillan, GP Gallun, FJ Dann, SM Konrad-Martin, D AF Molis, Michelle R. Kampel, Sean D. McMillan, Garnett P. Gallun, Frederick J. Dann, Serena M. Konrad-Martin, Dawn TI Effects of Hearing and Aging on Sentence-Level Time-Gated Word Recognition SO JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH LA English DT Article ID SPEECH RECOGNITION; PROCESSING SPEED; GATING PARADIGM; AGE; ADULTS; NOISE; SENSITIVITY; PERCEPTION; PERFORMANCE; RECEPTION AB Purpose: Aging is known to influence temporal processing, but its relationship to speech perception has not been clearly defined. To examine listeners' use of contextual and phonetic information, the Revised Speech Perception in Noise test (R-SPIN) was used to develop a time-gated word (TGW) task. Method: In Experiment 1, R-SPIN sentence lists were matched on context, target-word length, and median word segment length necessary for target recognition. In Experiment 2, TGW recognition was assessed in quiet and in noise among adults of various ages with normal hearing to moderate hearing loss. Linear regression models of the minimum word duration necessary for correct identification and identification failure rates were developed. Age and hearing thresholds were modeled as continuous predictors with corrections for correlations among multiple measurements of the same participants. Results: While aging and hearing loss both had significant impacts on task performance in the most adverse listening condition (low context, in noise), for most conditions, performance was limited primarily by hearing loss. Conclusion: Whereas hearing loss was strongly related to target-word recognition, the effect of aging was only weakly related to task performance. These results have implications for the design and evaluation of studies of hearing and aging. C1 [Molis, Michelle R.; Kampel, Sean D.; McMillan, Garnett P.; Gallun, Frederick J.; Dann, Serena M.; Konrad-Martin, Dawn] Portland VA Med Ctr, Natl Ctr Rehabil Auditory Res, Portland, OR USA. [Molis, Michelle R.; Gallun, Frederick J.; Konrad-Martin, Dawn] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. RP Molis, MR (reprint author), Portland VA Med Ctr, Natl Ctr Rehabil Auditory Res, Portland, OR USA. EM Michelle.Molis@va.gov FU Veterans Affairs Rehabilitation Research & Development Service [C7450R, C7113N, C6116W, C4963W]; National Center for Rehabilitative Auditory Research FX This work was supported by Veterans Affairs Rehabilitation Research & Development Service Grants C7450R, C7113N, C6116W, C4963W, and the National Center for Rehabilitative Auditory Research. Thanks to Kelly Reavis, Roger Ellingson, and Patrick Tsukuda for their work on this project. NR 35 TC 4 Z9 4 U1 0 U2 1 PU AMER SPEECH-LANGUAGE-HEARING ASSOC PI ROCKVILLE PA 10801 ROCKVILLE PIKE, ROCKVILLE, MD 20852-3279 USA SN 1092-4388 EI 1558-9102 J9 J SPEECH LANG HEAR R JI J. Speech Lang. Hear. Res. PD APR PY 2015 VL 58 IS 2 BP 481 EP 496 DI 10.1044/2015_JSLHR-H-14-0098 PG 16 WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation GA CL6ZF UT WOS:000357118000026 PM 25815688 ER PT J AU Sawaya, H Johnson, K Schmidt, M Arana, A Chahine, G Atoui, M Pincus, D George, MS Panksepp, J Nahas, Z AF Sawaya, Helen Johnson, Kevin Schmidt, Matthew Arana, Ashley Chahine, George Atoui, Mia Pincus, David George, Mark S. Panksepp, Jaak Nahas, Ziad TI Resting-State Functional Connectivity of Antero-Medial Prefrontal Cortex Sub-Regions in Major Depression and Relationship to Emotional Intelligence SO INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY LA English DT Article DE anterior medial PFC; emotional intelligence; major depression; MSCEIT; resting state functional connectivity ID DEFAULT MODE NETWORK; SOMATIC MARKER HYPOTHESIS; TREATMENT RESPONSE; DISORDER; MOOD; TRAIT AB Background: Major depressive disorder has been associated with abnormal resting-state functional connectivity (FC), especially in cognitive processing and emotional regulation networks. Although studies have found abnormal FC in regions of the default mode network (DMN), no study has investigated the FC of specific regions within the anterior DMN based on cytoarchitectonic subdivisions of the antero-medial pre-frontal cortex (PFC). Studies from different areas in the field have shown regions within the anterior DMN to be involved in emotional intelligence. Although abnormalities in this region have been observed in depression, the relationship between the ventromedial PFC (vmPFC) function and emotional intelligence has yet to be investigated in depressed individuals. Methods: Twenty-one medication-free, non-treatment resistant, depressed patients and 21 healthy controls underwent a resting state functional magnetic resonance imaging session. The participants also completed an ability-based measure of emotional intelligence: the Mayer-Salovey-Caruso Emotional Intelligence Test. FC maps of Brodmann areas (BA) 25, 10m, 10r, and 10p were created and compared between the two groups. Results: Mixed-effects analyses showed that the more anterior seeds encompassed larger areas of the DMN. Compared to healthy controls, depressed patients had significantly lower connectivity between BA10p and the right insula and between BA25 and the perigenual anterior cingulate cortex. Exploratory analyses showed an association between vmPFC connectivity and emotional intelligence. Conclusions: These results suggest that individuals with depression have reduced FC between antero-medial PFC regions and regions involved in emotional regulation compared to control subjects. Moreover, vmPFC functional connectivity appears linked to emotional intelligence. C1 [Sawaya, Helen; Chahine, George; Atoui, Mia; Nahas, Ziad] Amer Univ Beirut, Dept Psychiat, Beirut 2020, Lebanon. [Johnson, Kevin] Stanford Univ, Stanford, CA 94305 USA. [Schmidt, Matthew; Arana, Ashley; George, Mark S.] Med Univ S Carolina, Dept Psychiat, Brain Stimulat Lab, Charleston, SC USA. [Schmidt, Matthew; George, Mark S.] Ralph H Johnson VA Med Ctr, Charleston, SC USA. [Pincus, David] Cleveland Psychoanalyt Ctr Ohio, CWRU, Dept Psychiat, Cleveland, OH USA. [Pincus, David] Cleveland Psychoanalyt Ctr Ohio, CWRU, Dept Psychol, Cleveland, OH USA. [Panksepp, Jaak] Washington State Univ, Dept Integrat Physiol & Neurosci Washington, Pullman, WA 99164 USA. RP Nahas, Z (reprint author), Amer Univ Beirut, Box 11-0236,Riad El Solh 1107, Beirut 2020, Lebanon. EM zn17@aub.edu.lb FU National Institute of Mental Health, the Brain and Behavior Research Foundation; Hope for Depression Research Foundation; American University of Beirut's Intramural Funds; Medtronic Inc.; Massachusetts Emergency Care Training Academy; Pfizer; Centre National de la Recherche Scientifique FX This research was supported by grants from the National Institute of Mental Health, the Brain and Behavior Research Foundation (formally known as National Alliance of Research on Schizophrenia and Depression), the Hope for Depression Research Foundation, American University of Beirut's Intramural Funds, Medtronic Inc., Massachusetts Emergency Care Training Academy, Pfizer, and Centre National de la Recherche Scientifique. NR 50 TC 3 Z9 3 U1 3 U2 8 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1461-1457 EI 1469-5111 J9 INT J NEUROPSYCHOPH JI Int. J. Neuropsychopharmacol. PD APR PY 2015 VL 18 IS 6 DI 10.1093/ijnp/pyu112 PG 9 WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA CL1JY UT WOS:000356700000014 ER PT J AU Greysen, SR Cenzer, IS Auerbach, AD Covinsky, KE AF Greysen, S. Ryan Cenzer, Irena Stijacic Auerbach, Andrew D. Covinsky, Kenneth E. TI Functional Impairment and Hospital Readmission in Medicare Seniors SO JAMA INTERNAL MEDICINE LA English DT Article ID OLDER-ADULTS; RISK; HOME; ELDERS; DISABILITY; PREDICTION; DEPENDENCE; MORTALITY; ADMISSION; DISCHARGE AB IMPORTANCE Medicare currently penalizes hospitals for high readmission rates for seniors but does not account for common age-related syndromes, such as functional impairment. OBJECTIVE To assess the effects of functional impairment on Medicare hospital readmissions given the high prevalence of functional impairments in community-dwelling seniors. DESIGN, SETTING, AND PARTICIPANTS We created a nationally representative cohort of 7854 community-dwelling seniors in the Health and Retirement Study, with 22 289 Medicare hospitalizations from January 1, 2000, through December 31, 2010. MAIN OUTCOMES AND MEASURES Outcome was 30-day readmission assessed by Medicare claims. The main predictor was functional impairment determined from the Health and Retirement Study interview preceding hospitalization, stratified into the following 5 levels: no functional impairments, difficulty with 1 or more instrumental activities of daily living, difficulty with 1 or more activities of daily living (ADL), dependency (need for help) in 1 to 2 ADLs, and dependency in 3 or more ADLs. Adjustment variables included age, race/ethnicity, sex, annual income, net worth, comorbid conditions (Elixhauser score from Medicare claims), and prior admission. We performed multivariable logistic regression to adjust for clustering at the patient level to characterize the association of functional impairments and readmission. RESULTS Patients had a mean (SD) age of 78.5 (7.7) years (range, 65-105 years); 58.4% were female, 84.9% were white, 89.6% reported 3 or more comorbidities, and 86.0% had 1 or more hospitalizations in the previous year. Overall, 48.3% had some level of functional impairment before admission, and 15.5% of hospitalizations were followed by readmission within 30 days. We found a progressive increase in the adjusted risk of readmission as the degree of functional impairment increased: 13.5% with no functional impairment, 14.3% with difficulty with 1 or more instrumental activities of daily living (odds ratio [OR], 1.06; 95% CI, 0.94-1.20), 14.4% with difficulty with 1 or more ADL (OR, 1.08; 95% CI, 0.96-1.21), 16.5% with dependency in 1 to 2 ADLs (OR, 1.26; 95% CI, 1.11-1.44), and 18.2% with dependency in 3 or more ADLs (OR, 1.42; 95% CI, 1.20-1.69). Subanalysis restricted to patients admitted with conditions targeted by Medicare (ie, heart failure, myocardial infarction, and pneumonia) revealed a parallel trend with larger effects for the most impaired (16.9% readmission rate for no impairment vs 25.7% for dependency in 3 or more ADLs [OR, 1.70; 95% CI, 1.04-2.78]). CONCLUSIONS AND RELEVANCE Functional impairment is associated with increased risk of 30-day all-cause hospital readmission in Medicare seniors, especially those admitted for heart failure, myocardial infarction, or pneumonia. Functional impairment may be an important but underaddressed factor in preventing readmissions for Medicare seniors. C1 [Greysen, S. Ryan; Auerbach, Andrew D.] Univ Calif San Francisco, Div Hosp Med, San Francisco, CA 94113 USA. [Cenzer, Irena Stijacic; Covinsky, Kenneth E.] Univ Calif San Francisco, Div Geriatr Med, San Francisco, CA 94113 USA. [Cenzer, Irena Stijacic; Covinsky, Kenneth E.] San Francisco VA Med Ctr, San Francisco, CA USA. RP Greysen, SR (reprint author), Univ Calif San Francisco, Div Hosp Med, 533 Parnassus Ave,POB 0131, San Francisco, CA 94113 USA. EM ryan.greysen@ucsf.edu FU National Institutes of Health (NIH), National Institute of Aging (NIA) through the Claude D. Pepper Older Americans Independence Center [P30AG021342 NIH/NIA]; NIH-NIA; NIA; National Institute for Nursing Research; [1K23AG045338-01] FX Dr Greysen is supported by the National Institutes of Health (NIH), National Institute of Aging (NIA) through the Claude D. Pepper Older Americans Independence Center (grant P30AG021342 NIH/NIA), a Career Development Award (grant 1K23AG045338-01), and the NIH-NIA Loan Repayment Program. Dr Covinsky is supported by the NIA through a K-24 Career Mentoring Award and an R01 from the National Institute for Nursing Research. NR 38 TC 30 Z9 30 U1 4 U2 10 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6106 EI 2168-6114 J9 JAMA INTERN MED JI JAMA Intern. Med. PD APR PY 2015 VL 175 IS 4 BP 559 EP 565 DI 10.1001/jamainternmed.2014.7756 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA CK4FJ UT WOS:000356177100019 PM 25642907 ER PT J AU Bachhuber, MA Saloner, B Barry, CL AF Bachhuber, Marcus A. Saloner, Brendan Barry, Colleen L. TI What Ecologic Analyses Cannot Tell Us About Medical Marijuana Legalization and Opioid Pain Medication Mortality Reply SO JAMA INTERNAL MEDICINE LA English DT Letter ID INDIVIDUALS C1 [Bachhuber, Marcus A.] Philadelphia Vet Affairs Med Ctr, Ctr Hlth Equ Res & Promot, Philadelphia, PA 19104 USA. [Bachhuber, Marcus A.] Univ Penn, Robert Wood Johnson Fdn Clin Scholars Program, Philadelphia, PA 19104 USA. [Bachhuber, Marcus A.; Barry, Colleen L.] Univ Penn, Leonard Davis Inst Hlth Econ, Philadelphia, PA 19104 USA. [Saloner, Brendan; Barry, Colleen L.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, Baltimore, MD USA. [Saloner, Brendan; Barry, Colleen L.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mental Hlth, Baltimore, MD USA. RP Bachhuber, MA (reprint author), Philadelphia Vet Affairs Med Ctr, Ctr Hlth Equ Res & Promot, 423 Guardian Dr,1303-A Blockley Hall, Philadelphia, PA 19104 USA. EM marcus.bachhuber@gmail.com OI Bachhuber, Marcus/0000-0002-5610-8382 NR 6 TC 0 Z9 0 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6106 EI 2168-6114 J9 JAMA INTERN MED JI JAMA Intern. Med. PD APR PY 2015 VL 175 IS 4 BP 656 EP 657 DI 10.1001/jamainternmed.2014.8027 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA CK4FJ UT WOS:000356177100057 PM 25844749 ER PT J AU Green, J Yule, C Berger, A Weisbord, S AF Green, Jamie Yule, Christina Berger, Andrea Weisbord, Steven TI PATIENT PERSPECTIVES ON CHRONIC KIDNEY DISEASE SELF-MANAGEMENT SO AMERICAN JOURNAL OF KIDNEY DISEASES LA English DT Meeting Abstract CT Spring Clinical Meeting of National-Kidney-Foundation CY MAR 25-29, 2015 CL Grapevine, TX SP Natl Kidney Fdn C1 [Green, Jamie; Yule, Christina; Berger, Andrea] Geisinger Med Ctr, Danville, PA 17822 USA. [Weisbord, Steven] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0272-6386 EI 1523-6838 J9 AM J KIDNEY DIS JI Am. J. Kidney Dis. PD APR PY 2015 VL 65 IS 4 MA 98 BP A39 EP A39 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA CJ9BE UT WOS:000355796500101 ER PT J AU Judy, T Anita, M Rajeev, R AF Judy, Tan Anita, Mehrotra Rajeev, Rohatgi TI TELENEPHROLOGY FOR THE REMOTE MANAGEMENT OF CHRONIC KIDNEY DISEASE: A RETROSPECTIVE COHORT STUDY SO AMERICAN JOURNAL OF KIDNEY DISEASES LA English DT Meeting Abstract CT Spring Clinical Meeting of National-Kidney-Foundation CY MAR 25-29, 2015 CL Grapevine, TX SP Natl Kidney Fdn C1 [Judy, Tan; Anita, Mehrotra; Rajeev, Rohatgi] Mt Sinai Hosp, New York, NY 10029 USA. [Rajeev, Rohatgi] James J Peters VAMC, Bronx, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0272-6386 EI 1523-6838 J9 AM J KIDNEY DIS JI Am. J. Kidney Dis. PD APR PY 2015 VL 65 IS 4 MA 275 BP A83 EP A83 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA CJ9BE UT WOS:000355796500278 ER PT J AU Nelson, J Yule, C Berger, A Weisbord, S Green, J AF Nelson, Jessica Yule, Christina Berger, Andrea Weisbord, Steven Green, Jamie TI PREVALENCE AND CORRELATES OF MEDICATION ADHERENCE IN PATIENTS WITH CHRONIC KIDNEY DISEASE SO AMERICAN JOURNAL OF KIDNEY DISEASES LA English DT Meeting Abstract CT Spring Clinical Meeting of National-Kidney-Foundation CY MAR 25-29, 2015 CL Grapevine, TX SP Natl Kidney Fdn C1 [Nelson, Jessica; Yule, Christina; Berger, Andrea; Green, Jamie] Geisinger Med Ctr, Danville, PA 17822 USA. [Weisbord, Steven] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0272-6386 EI 1523-6838 J9 AM J KIDNEY DIS JI Am. J. Kidney Dis. PD APR PY 2015 VL 65 IS 4 MA 184 BP A60 EP A60 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA CJ9BE UT WOS:000355796500187 ER PT J AU Nelson, J Yule, C Berger, A Weisbord, S Green, J AF Nelson, Jessica Yule, Christina Berger, Andrea Weisbord, Steven Green, Jamie TI ASSOCIATION OF HEALTH LITERACY WITH MEDICATION SELF-MANAGEMENT SO AMERICAN JOURNAL OF KIDNEY DISEASES LA English DT Meeting Abstract CT Spring Clinical Meeting of National-Kidney-Foundation CY MAR 25-29, 2015 CL Grapevine, TX SP Natl Kidney Fdn C1 [Nelson, Jessica; Yule, Christina; Berger, Andrea; Green, Jamie] Geisinger Med Ctr, Danville, PA 17822 USA. [Weisbord, Steven] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0272-6386 EI 1523-6838 J9 AM J KIDNEY DIS JI Am. J. Kidney Dis. PD APR PY 2015 VL 65 IS 4 MA 183 BP A60 EP A60 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA CJ9BE UT WOS:000355796500186 ER PT J AU Sultan, G Agarwal, G Dah, K Wagner, B Werner, S AF Sultan, G. Agarwal, G. Dah, K. Wagner, B. Werner, S. TI IMMUNOTACTOID GLOMERULOPATHY WITH MEMBRANOUS PATTERN IN PATIENT WITH RHEUMATOID ARTHRITIS AND MONOCLONAL GAMMOPATHY SO AMERICAN JOURNAL OF KIDNEY DISEASES LA English DT Meeting Abstract CT Spring Clinical Meeting of National-Kidney-Foundation CY MAR 25-29, 2015 CL Grapevine, TX SP Natl Kidney Fdn C1 Univ Texas San Antonio, Dept Nephrol, San Antonio, TX USA. Univ Texas San Antonio, Dept Pathol, San Antonio, TX USA. South Texas Vet Hlth Care Syst, Dept Nephrol, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0272-6386 EI 1523-6838 J9 AM J KIDNEY DIS JI Am. J. Kidney Dis. PD APR PY 2015 VL 65 IS 4 MA 271 BP A82 EP A82 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA CJ9BE UT WOS:000355796500274 ER PT J AU Binh, TT Suzuki, R Trang, TTH Kwon, DH Yamaoka, Y AF Tran Thanh Binh Suzuki, Rumiko Tran Thi Huyen Trang Kwon, Dong Hyeon Yamaoka, Yoshio TI Search for Novel Candidate Mutations for Metronidazole Resistance in Helicobacter pylori Using Next-Generation Sequencing SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID RDXA GENE; ANTIBIOTIC-RESISTANCE; CLARITHROMYCIN RESISTANCE; PROTEIN-SYNTHESIS; STRAIN 908; ERADICATION; INFECTION; FRXA; GENOME; NITROREDUCTASE AB Metronidazole resistance is a key factor associated with Helicobacter pylori treatment failure. Although this resistance is mainly associated with mutations in the rdxA and frxA genes, the question of whether metronidazole resistance is caused by the inactivation of frxA alone is still debated. Furthermore, it is unclear whether there are other mutations involved in addition to the two genes that are associated with resistance. A metronidazole-resistant strain was cultured from the metronidazole-susceptible H. pylori strain 26695-1 by exposure to low concentrations of metronidazole. The genome sequences of both susceptible and resistant H. pylori strains were determined by Illumina next-generation sequencing, from which putative candidate resistance mutations were identified. Natural transformation was used to introduce PCR products containing candidate mutations into the susceptible parent strain 26695-1, and the metronidazole MIC was determined for each strain. Mutations in frxA (hp0642), rdxA (hp0954), and rpsU (hp0562) were confirmed by the Sanger method. The mutated sequence in rdxA was successfully transformed into strain 26695-1, and the transformants showed resistance to metronidazole. The transformants containing a single mutation in rdxA showed a low MIC (16 mg/liter), while those containing mutations in both rdxA and frxA showed a higher MIC (48 mg/liter). No transformants containing a single mutation in frxA or rpsU were obtained. Next-generation sequencing was used to identify mutations related to drug resistance. We confirmed that the mutations in rdxA are mainly associated with metronidazole resistance, and mutations in frxA are able to enhance H. pylori resistance only in the presence of rdxA mutations. Moreover, mutations in rpsU may play a role in metronidazole resistance. C1 [Tran Thanh Binh; Suzuki, Rumiko; Tran Thi Huyen Trang; Yamaoka, Yoshio] Oita Univ, Fac Med, Dept Environm & Prevent Med, Yufu, Japan. [Tran Thanh Binh] Cho Ray Hosp, Dept Endoscopy, Ho Chi Minh City, Vietnam. [Kwon, Dong Hyeon] Long Isl Univ, Dept Biol, Brooklyn, NY USA. [Yamaoka, Yoshio] Baylor Coll Med, Dept Med Gastroenterol, Houston, TX 77030 USA. [Yamaoka, Yoshio] Baylor Coll Med, Michael E DeBakey Vet Affairs Med Ctr, Houston, TX 77030 USA. RP Yamaoka, Y (reprint author), Oita Univ, Fac Med, Dept Environm & Prevent Med, Yufu, Japan. EM yyamaoka@oita-u.ac.jp FU Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan [25293104, 24659200, 24406015]; Special Co-ordination Funds for Promoting Science and Technology from the MEXT of Japan; National Institutes of Health [DK62813, GM94053]; Japanese Government (Monbukagakusho, MEXT) Scholarship Program FX This study was supported by grants-in-aid for scientific research from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan (25293104, 24659200, and 24406015) (to Y.Y.), the Special Co-ordination Funds for Promoting Science and Technology from the MEXT of Japan (to Y.Y.), and National Institutes of Health grants DK62813 (to Y.Y.) and GM94053 (to D.H.K.). T.T.B. is a doctoral student supported by the Japanese Government (Monbukagakusho, MEXT) Scholarship Program for 2010. NR 59 TC 9 Z9 10 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD APR PY 2015 VL 59 IS 4 BP 2343 EP 2348 DI 10.1128/AAC.04852-14 PG 6 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA CI8BY UT WOS:000354993700061 PM 25645832 ER PT J AU Beidas, RS Marcus, S Aarons, GA Hoagwood, KE Schoenwald, S Evans, AC Hurford, MO Hadley, T Barg, FK Walsh, LM Adams, DR Mandell, DS AF Beidas, Rinad S. Marcus, Steven Aarons, Gregory A. Hoagwood, Kimberly E. Schoenwald, Sonja Evans, Arthur C. Hurford, Matthew O. Hadley, Trevor Barg, Frances K. Walsh, Lucia M. Adams, Danielle R. Mandell, David S. TI Predictors of Community Therapists' Use of Therapy Techniques in a Large Public Mental Health System SO JAMA PEDIATRICS LA English DT Article ID ORGANIZATIONAL SOCIAL-CONTEXT; CHILDRENS SERVICE SYSTEMS; TREATMENT FIDELITY; WELFARE SYSTEMS; FAMILY-THERAPY; IMPLEMENTATION; ATTITUDES; CLIMATE; OUTCOMES; YOUTH AB IMPORTANCE Few studies have examined the effects of individual and organizational characteristics on the use of evidence-based practices in mental health care. Improved understanding of these factors could guide future implementation efforts to ensure effective adoption, implementation, and sustainment of evidence-based practices. OBJECTIVE To estimate the relative contribution of individual and organizational factors on therapist self-reported use of cognitive-behavioral, family, and psychodynamic therapy techniques within the context of a large-scale effort to increase use of evidence-based practices in an urban public mental health system serving youth and families. DESIGN, SETTING, AND PARTICIPANTS In this observational, cross-sectional study of 23 organizations, data were collected from March 1 through July 25, 2013. We used purposive sampling to recruit the 29 largest child-serving agencies, which together serve approximately 80% of youth receiving publically funded mental health care. The final sample included 19 agencies with 23 sites, 130 therapists, 36 supervisors, and 22 executive administrators. MAIN OUTCOMES AND MEASURES Therapist self-reported use of cognitive-behavioral, family, and psychodynamic therapy techniques, as measured by the Therapist Procedures Checklist-Family Revised. RESULTS Individual factors accounted for the following percentages of the overall variation: cognitive-behavioral therapy techniques, 16%; family therapy techniques, 7%; and psychodynamic therapy techniques, 20%. Organizational factors accounted for the following percentages of the overall variation: cognitive-behavioral therapy techniques, 23%; family therapy techniques, 19%; and psychodynamic therapy techniques, 7%. Older therapists and therapists with more open attitudes were more likely to endorse use of cognitive-behavioral therapy techniques, as were those in organizations that had spent fewer years participating in evidence-based practice initiatives, had more resistant cultures, and had more functional climates. Women were more likely to endorse use of family therapy techniques, as were those in organizations employing more fee-for-service staff and with more stressful climates. Therapists with more divergent attitudes and less knowledge about evidence-based practices were more likely to use psychodynamic therapy techniques. CONCLUSIONS AND RELEVANCE This study suggests that individual and organizational factors are important in explaining therapist behavior and use of evidence-based practices, but the relative importance varies by therapeutic technique. C1 [Beidas, Rinad S.; Evans, Arthur C.; Hurford, Matthew O.; Hadley, Trevor; Walsh, Lucia M.; Adams, Danielle R.; Mandell, David S.] Univ Penn, Perelman Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA. [Marcus, Steven] Univ Penn, Sch Social Policy & Practice, Philadelphia, PA 19104 USA. [Marcus, Steven] Philadelphia Vet Affairs Med Ctr, Ctr Hlth Equ Res & Promot, Philadelphia, PA USA. [Aarons, Gregory A.] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA. [Hoagwood, Kimberly E.] NYU, Dept Psychiat, New York, NY 10016 USA. [Schoenwald, Sonja] Med Univ S Carolina, Dept Psychiat & Behav Sci, Charleston, SC USA. [Evans, Arthur C.; Hurford, Matthew O.] Dept Behav Hlth & Intellectual Disabil Serv, Philadelphia, PA USA. [Hurford, Matthew O.] Community Behav Hlth, Philadelphia, PA USA. [Barg, Frances K.] Univ Penn, Perelman Sch Med, Dept Family Med & Community Hlth, Philadelphia, PA 19104 USA. RP Beidas, RS (reprint author), Univ Penn, Perelman Sch Med, Dept Psychiat, 3535 Market St,3015, Philadelphia, PA 19104 USA. EM rbeidas@upenn.edu RI Mandell, David/H-2730-2012 OI Mandell, David/0000-0001-8240-820X FU Implementation Research Institute fellowship from the National Institute of Mental Health [K23 MH099179]; Implementation Research Institute, George Warren Brown School of Social Work, Washington University, St Louis, Missouri; National Institute of Mental Health [R25 MH080916]; Quality Enhancement Research Initiative, Department of Veterans Affairs Contract, Veterans Health Administration, Office of Research and Development, Health Services Research and Development Service FX This study was supported by grant K23 MH099179 and an Implementation Research Institute fellowship (2012-2014) from the National Institute of Mental Health (Dr Beidas); the Implementation Research Institute, George Warren Brown School of Social Work, Washington University, St Louis, Missouri; grant R25 MH080916 from the National Institute of Mental Health; and the Quality Enhancement Research Initiative, Department of Veterans Affairs Contract, Veterans Health Administration, Office of Research and Development, Health Services Research and Development Service. NR 38 TC 20 Z9 20 U1 3 U2 14 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6203 EI 2168-6211 J9 JAMA PEDIATR JI JAMA Pediatr. PD APR PY 2015 VL 169 IS 4 BP 374 EP 382 DI 10.1001/jamapediatrics.2014.3736 PG 9 WC Pediatrics SC Pediatrics GA CI8CP UT WOS:000354995600021 PM 25686473 ER PT J AU Cohen, BE Shi, Y Neylan, TC Maguen, S Seal, KH AF Cohen, Beth E. Shi, Ying Neylan, Thomas C. Maguen, Shira Seal, Karen H. TI Antipsychotic Prescriptions in Iraq and Afghanistan Veterans With Posttraumatic Stress Disorder in Department of Veterans Affairs Healthcare, 2007-2012 SO JOURNAL OF CLINICAL PSYCHIATRY LA English DT Article ID CARDIOVASCULAR RISK; DIAGNOSES; TRENDS; PTSD; METAANALYSIS; RISPERIDONE AB Objective: Antipsychotic medications have been increasingly prescribed for off-label uses, including treatment of posttraumatic stress disorder (PTSD). Given limited knowledge about their use in returning Iraq and Afghanistan veterans with PTSD, we explored rates of antipsychotic use in this population and correlations with sociodemographic, military service, and psychiatric factors. Method: Iraq and Afghanistan veterans with a PTSD diagnosis based on ICD-9-CM codes enrolled in Veterans Administration care between January 1, 2007, and September 30, 2011, were followed through September 30, 2012. Patients with a comorbid diagnosis of schizophrenia or bipolar disorder were excluded. Poisson regression models evaluated factors associated with prescriptions for antipsychotic versus other psychiatric medications (primary outcome). Results: The mean age of our study population was 29.3 years, and 9.4% were women. Of 186,460 veterans with PTSD diagnoses examined, 19.9% received no psychiatric medications, and the remainder received psychiatric medications that excluded (61.2%) or included (18.9%) antipsychotics. In adjusted models, several factors were independently associated with antipsychotic use, including male sex (adjusted relative risk = 1.25; 95% CI, 1.20-1.30) and enlisted rank (1.44; 95% CI, 1.35-1.53). Increased likelihood of antipsychotic prescribing was associated with suicidal ideation (4.77; 95% CI, 4.59-4.95) and comorbid psychiatric diagnoses including personality disorder (4.27; 95% CI, 4.09-4.46), drug use disorder (3.56; 95% CI, 3.43-3.69), and alcohol use disorder (2.75; 95% CI, 2.65-2.84). Conclusions: A substantial minority of Iraq and Afghanistan veterans diagnosed with PTSD received antipsychotics. Male veterans, those of enlisted rank, and those with suicidal ideation and psychiatric comorbidities were more likely to receive antipsychotics than other types of psychiatric medications. Providers should be cautious about antipsychotic use, given their known metabolic risks and questionable benefits for PTSD. C1 [Cohen, Beth E.; Seal, Karen H.] Univ Calif San Francisco, Dept Med, San Francisco, CA USA. [Neylan, Thomas C.; Maguen, Shira; Seal, Karen H.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA. [Cohen, Beth E.; Shi, Ying; Neylan, Thomas C.; Maguen, Shira; Seal, Karen H.] San Francisco VA Med Ctr, San Francisco, CA USA. RP Cohen, BE (reprint author), San Francisco VA Med Ctr, Box 111A1,4150 Clement St, San Francisco, CA 94120 USA. EM Beth.Cohen@va.gov FU National Heart, Lung, and Blood Institute grant [K23 HL 094765-01]; American Heart Association Clinical Research Program; VA Health Services Research and Development Research Enhancement Award Program at San Francisco VA Medical Center FX Dr Cohen was supported by National Heart, Lung, and Blood Institute grant K23 HL 094765-01 and a grant from the American Heart Association Clinical Research Program. This work was also supported by the VA Health Services Research and Development Research Enhancement Award Program at the San Francisco VA Medical Center. NR 26 TC 1 Z9 1 U1 0 U2 1 PU PHYSICIANS POSTGRADUATE PRESS PI MEMPHIS PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA SN 0160-6689 EI 1555-2101 J9 J CLIN PSYCHIAT JI J. Clin. Psychiatry PD APR PY 2015 VL 76 IS 4 BP 406 EP + DI 10.4088/JCP.13m08857 PG 12 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA CI8DA UT WOS:000354997500021 PM 25845036 ER PT J AU Gabrielian, S Bromley, E Hellemann, GS Kern, RS Goldenson, NI Danley, ME Young, AS AF Gabrielian, Sonya Bromley, Elizabeth Hellemann, Gerhard S. Kern, Robert S. Goldenson, Nicholas I. Danley, Megan E. Young, Alexander S. TI Factors Affecting Exits From Homelessness Among Persons With Serious Mental Illness and Substance Use Disorders SO JOURNAL OF CLINICAL PSYCHIATRY LA English DT Article ID COGNITIVE ASSESSMENT-TOOL; QUALITY-OF-LIFE; SOCIAL SUPPORT; SCREENING-TEST; VOCATIONAL-REHABILITATION; PSYCHOMETRIC PROPERTIES; COMMUNITY INTEGRATION; OLDER-ADULTS; SCHIZOPHRENIA; HEALTH AB Objective: We sought to understand the housing trajectories of homeless consumers with serious mental illness (SMI) and co-occurring substance use disorders (SUD) and to identify factors that best predicted achievement of independent housing. Method: Using administrative data, we identified homeless persons with SMI and SUD admitted to a residential rehabilitation program from December 2008 to November 2011. Our primary outcome measure was independent housing status. On a random sample (N = 36), we assessed a range of potential predictors of housing outcomes, including symptoms, cognition, and social/community supports. We used the Residential Time-Line Follow-Back (TLFB) Inventory to gather housing histories since exiting rehabilitation and to identify housing outcomes. We used Recursive Partitioning (RP) to identify variables that best differentiated participants by these outcomes. Results: We identified 3 housing trajectories: stable housing (n = 14), unstable housing (n = 15), and continuously engaged in housing services (n = 7). In RP analysis, 2 variables (Symbol Digit Modalities Test [SDMT], a neurocognitive speed of processing measure, and Behavior and Symptom Identification Scale [BASIS-24] Relationships subscale, which quantifies symptoms affecting relationships) were sufficient to capture information provided by 26 predictors to classify participants by housing outcome. Participants predicted to continuously engage in services had impaired processing speeds (SDMT score < 32.5). Among consumers with SDMT score = 32.5, those predicted to achieve stable housing had fewer interpersonal symptoms (BASIS-24 Relationships subscale score < 0.81) than those predicted to have unstable housing. This model explains 57% of this sample's variability and 14% of this population's variability in housing outcomes. Conclusions: Because cognition and symptoms influencing relationships predicted housing outcomes for homeless adults with SMI and SUD, cognitive and social skills training may be useful for this population. (C) Copyright 2015 Physicians Postgraduate Press, Inc. C1 [Gabrielian, Sonya; Bromley, Elizabeth; Young, Alexander S.] Greater Los Angeles Healthcare Syst, US Dept Vet Affairs, Dept Psychiat, Los Angeles, CA 90073 USA. [Gabrielian, Sonya; Bromley, Elizabeth; Hellemann, Gerhard S.; Kern, Robert S.; Young, Alexander S.] Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA. [Gabrielian, Sonya; Bromley, Elizabeth; Kern, Robert S.; Young, Alexander S.] Vet Affairs Greater Los Angeles Healthcare Syst, Dept Vet Affairs VISN22, MIRECC, Los Angeles, CA USA. [Gabrielian, Sonya; Bromley, Elizabeth; Hellemann, Gerhard S.; Young, Alexander S.] VA Ctr Study Healthcare Innovat Implementat & Pol, North Hills, CA USA. [Goldenson, Nicholas I.] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA. [Danley, Megan E.] Univ Calif San Francisco, Sch Med, Dept Phys Therapy & Rehabil Sci, San Francisco, CA USA. RP Gabrielian, S (reprint author), Greater Los Angeles Healthcare Syst, US Dept Vet Affairs, 11301 Wilshire Blvd,Bldg 210A, Los Angeles, CA 90073 USA. EM sonya.gabrielian@va.gov FU Department of Veterans Affairs VISN22 MIRECC Pala Grant (Los Angeles, California); VA Center for the Study of Healthcare Innovation, Implementation, and Policy (North Hills, California); Veterans Health Administration, Office of Research and Development, Health Services Research and Development (Washington, DC) [RRP 12-259]; Office of Academic Affiliations, Advanced Fellowship Program in Mental Illness Research and Treatment, US Department of Veterans Affairs FX This material is based upon work supported by a Department of Veterans Affairs VISN22 MIRECC Pala Grant (Los Angeles, California); Locally Initiated Project funds from the VA Center for the Study of Healthcare Innovation, Implementation, and Policy (North Hills, California); and the Veterans Health Administration, Office of Research and Development, Health Services Research and Development, RRP 12-259 (Washington, DC). Dr Gabrielian was supported in part by the Office of Academic Affiliations, Advanced Fellowship Program in Mental Illness Research and Treatment, US Department of Veterans Affairs. NR 61 TC 1 Z9 1 U1 0 U2 18 PU PHYSICIANS POSTGRADUATE PRESS PI MEMPHIS PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA SN 0160-6689 EI 1555-2101 J9 J CLIN PSYCHIAT JI J. Clin. Psychiatry PD APR PY 2015 VL 76 IS 4 BP E469 EP E476 DI 10.4088/JCP.14m09229 PG 8 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA CI8DA UT WOS:000354997500001 PM 25919839 ER PT J AU Pietrzak, RH Sumner, JA Aiello, AE Uddin, M Neumeister, A Guffanti, G Koenen, KC AF Pietrzak, Robert H. Sumner, Jennifer A. Aiello, Allison E. Uddin, Monica Neumeister, Alexander Guffanti, Guia Koenen, Karestan C. TI Association of the rs2242446 Polymorphism in the Norepinephrine Transporter Gene SLC6A2 and Anxious Arousal Symptoms of Posttraumatic Stress Disorder SO JOURNAL OF CLINICAL PSYCHIATRY LA English DT Letter ID PANIC DISORDER C1 [Pietrzak, Robert H.] VA Connecticut Healthcare Syst, US Dept Vet Affairs, Natl Ctr Posttraumat Stress Disorder, Clin Neurosci Div, West Haven, CT 06516 USA. [Pietrzak, Robert H.] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA. [Sumner, Jennifer A.; Guffanti, Guia; Koenen, Karestan C.] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA. [Aiello, Allison E.] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. [Uddin, Monica] Wayne State Univ, Sch Med, Ctr Mol Med & Genet, Detroit, MI USA. [Uddin, Monica] Wayne State Univ, Sch Med, Dept Psychiat & Behav Neurosci, Detroit, MI USA. [Neumeister, Alexander] NYU, Sch Med, Dept Psychiat, New York, NY USA. [Neumeister, Alexander] NYU, Dept Radiol, Sch Med, New York, NY 10016 USA. RP Pietrzak, RH (reprint author), VA Connecticut Healthcare Syst, US Dept Vet Affairs, Natl Ctr Posttraumat Stress Disorder, Clin Neurosci Div, West Haven, CT 06516 USA. EM robert.pietrzak@yale.edu FU National Institutes of Health [R01DA022720, R01DA022720-S1 [PhenX], R01DA022720-S1 [Supplement], RC1MH088283]; US Department of Veterans Affairs National Center for Posttraumatic Stress Disorder FX This research was funded by National Institutes of Health grants (R01DA022720, R01DA022720-S1 [PhenX], R01DA022720-S1 [Supplement], and RC1MH088283). Preparation of this report was supported in part by the US Department of Veterans Affairs National Center for Posttraumatic Stress Disorder and a private donation. NR 8 TC 3 Z9 3 U1 0 U2 4 PU PHYSICIANS POSTGRADUATE PRESS PI MEMPHIS PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA SN 0160-6689 EI 1555-2101 J9 J CLIN PSYCHIAT JI J. Clin. Psychiatry PD APR PY 2015 VL 76 IS 4 BP E537 EP E538 DI 10.4088/JCP.14l09346 PG 2 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA CI8DA UT WOS:000354997500015 PM 25919853 ER PT J AU Suri, P Lorbergs, A Travison, TG Meng, CA Jarraya, M Guermazi, A Samelson, EJ AF Suri, P. Lorbergs, A. Travison, T. G. Meng, C. -A. Jarraya, M. Guermazi, A. Samelson, E. J. TI PHYSICAL ACTIVITY AND 6-YEAR INCIDENCE OF FACET JOINT OSTEOARTHRITIS IN WOMEN AND MEN: THE FRAMINGHAM STUDY SO OSTEOARTHRITIS AND CARTILAGE LA English DT Meeting Abstract CT World Congress of the Osteoarthritis-Research-Society-International (OARSI) on Osteoarthritis CY APR 30-MAY 03, 2015 CL Seattle, WA SP Osteoarthritis Res Soc Int C1 [Suri, P.] Univ Washington, Sch Med, VA Puget Sound Hlth Care Syst, Seattle, WA USA. [Suri, P.] Harvard Univ, Sch Med, Boston, MA USA. [Suri, P.] Hebrew SeniorLife, Boston, MA USA. [Suri, P.] Mercy Hlth, Philadelphia, PA USA. [Suri, P.] Boston Univ, Sch Med, Boston, MA 02118 USA. [Suri, P.] Harvard Univ, Sch Med, Hebrew SeniorLife, Boston, MA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1063-4584 EI 1522-9653 J9 OSTEOARTHR CARTILAGE JI Osteoarthritis Cartilage PD APR PY 2015 VL 23 SU 2 MA 270 BP A176 EP A176 PG 1 WC Orthopedics; Rheumatology SC Orthopedics; Rheumatology GA CI8VC UT WOS:000355048800300 ER PT J AU Criner, GJ Bourbeau, J Diekemper, RL Ouellette, DR Goodridge, D Hernandez, P Curren, K Balter, MS Bhutani, M Camp, PG Celli, BR Dechman, G Dransfield, MT Fiel, SB Foreman, MG Hanania, NA Ireland, BK Marchetti, N Marciniuk, DD Mularski, RA Ornelas, J Road, JD Stickland, MK AF Criner, Gerard J. Bourbeau, Jean Diekemper, Rebecca L. Ouellette, Daniel R. Goodridge, Donna Hernandez, Paul Curren, Kristen Balter, Meyer S. Bhutani, Mohit Camp, Pat G. Celli, Bartolome R. Dechman, Gail Dransfield, Mark T. Fiel, Stanley B. Foreman, Marilyn G. Hanania, Nicola A. Ireland, Belinda K. Marchetti, Nathaniel Marciniuk, Darcy D. Mularski, Richard A. Ornelas, Joseph Road, Jeremy D. Stickland, Michael K. TI Prevention of Acute Exacerbation of COPD: American College of Chest Physicians and Canadian Thoracic Society Guideline SO CHEST LA English DT Article ID OBSTRUCTIVE PULMONARY-DISEASE; IMPROVING PRIMARY-CARE; COMPLEX INTERVENTIONS; CHRONIC ILLNESS; RECOMMENDATIONS; MANAGEMENT; DIAGNOSIS; OUTCOMES; QUALITY; UPDATE C1 [Criner, Gerard J.] Temple Univ, Sch Med, Philadelphia, PA 19140 USA. [Bourbeau, Jean] McGill Univ, Resp Epidemiol & Clin Res Unit, Montreal Chest Inst, Ctr Hlth, Montreal, PQ, Canada. [Diekemper, Rebecca L.; Ornelas, Joseph] Amer Coll Chest Phys, Glenview, IL USA. [Ouellette, Daniel R.] Henry Ford Hlth Syst, Detroit, MI USA. [Goodridge, Donna] Univ Saskatchewan, Coll Med, Saskatoon, SK S7N 0W0, Canada. [Hernandez, Paul] Dalhousie Univ, Dept Med, Halifax, NS, Canada. [Dechman, Gail] Dalhousie Univ, Sch Physiotherapy, Halifax, NS, Canada. [Curren, Kristen] Canadian Thorac Soc, Ottawa, ON, Canada. [Balter, Meyer S.] Univ Toronto, Div Respirol, Toronto, ON, Canada. [Bhutani, Mohit] Univ Alberta, Edmonton, AB, Canada. [Camp, Pat G.] Univ British Columbia, Dept Phys Therapy, Vancouver, BC V5Z 1M9, Canada. [Celli, Bartolome R.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA. [Dransfield, Mark T.] Univ Alabama Birmingham, Birmingham, AL USA. [Dransfield, Mark T.] Birmingham VA Med Ctr, Birmingham, AL USA. [Fiel, Stanley B.] Atlantic Hlth Syst, Med Ctr, Morristown, NJ USA. [Foreman, Marilyn G.] Morehouse Sch Med, Atlanta, GA 30310 USA. [Hanania, Nicola A.] Baylor Coll Med, Houston, TX 77030 USA. [Ireland, Belinda K.] TheEvidenceDoc LLC, Pacifi, MO USA. [Marchetti, Nathaniel] Temple Univ, Sch Med, Philadelphia, PA USA. [Marciniuk, Darcy D.] Univ Saskatchewan, Div Respirol Crit Care & Sleep Med, Royal Univ Hosp, Saskatoon, SK, Canada. [Mularski, Richard A.] Kaiser Permanente Ctr Hlth Res, Portland, OR USA. [Road, Jeremy D.] Univ British Columbia, Dept Med, Vancouver, BC, Canada. [Stickland, Michael K.] Univ Alberta, Div Pulm Med, Edmonton, AB, Canada. RP Criner, GJ (reprint author), Temple Univ, Sch Med, Dept Pulm & Crit Care Med, 745 Parkinson Pavilion,3401 N Broad St, Philadelphia, PA 19140 USA. EM gerard.criner@tuhs.temple.edu FU NHLBI NIH HHS [K01 HL092601]; NIMHD NIH HHS [S21 MD000101] NR 32 TC 16 Z9 17 U1 1 U2 5 PU AMER COLL CHEST PHYSICIANS PI GLENVIEW PA 2595 PATRIOT BLVD, GLENVIEW, IL 60026 USA SN 0012-3692 J9 CHEST JI Chest PD APR PY 2015 VL 147 IS 4 BP 883 EP 893 DI 10.1378/chest.14-1677 PG 11 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA CI2VT UT WOS:000354606300021 PM 25320966 ER PT J AU Criner, GJ Bourbeau, J Diekemper, RL Ouellette, DR Goodridge, D Hernandez, P Curren, K Balter, MS Bhutani, M Camp, PG Celli, BR Dechman, G Dransfield, MT Fiel, SB Foreman, MG Hanania, NA Ireland, BK Marchetti, N Marciniuk, DD Mularski, RA Ornelas, J Road, JD Stickland, MK AF Criner, Gerard J. Bourbeau, Jean Diekemper, Rebecca L. Ouellette, Daniel R. Goodridge, Donna Hernandez, Paul Curren, Kristen Balter, Meyer S. Bhutani, Mohit Camp, Pat G. Celli, Bartolome R. Dechman, Gail Dransfield, Mark T. Fiel, Stanley B. Foreman, Marilyn G. Hanania, Nicola A. Ireland, Belinda K. Marchetti, Nathaniel Marciniuk, Darcy D. Mularski, Richard A. Ornelas, Joseph Road, Jeremy D. Stickland, Michael K. TI Prevention of Acute Exacerbations of COPD American College of Chest Physicians and Canadian Thoracic Society Guideline SO CHEST LA English DT Article ID OBSTRUCTIVE PULMONARY-DISEASE; RANDOMIZED CONTROLLED-TRIAL; PLACEBO-CONTROLLED TRIAL; LONG-TERM TREATMENT; FLUTICASONE PROPIONATE/SALMETEROL 250/50; INHALED ANTICHOLINERGIC BRONCHODILATOR; SMOKING-CESSATION INTERVENTION; CLINICAL-PRACTICE GUIDELINE; CHRONIC RESPIRATORY-FAILURE; SLOW-RELEASE THEOPHYLLINE AB BACKGROUND: COPD is a major cause of morbidity and mortality in the United States as well as throughout the rest of the world. An exacerbation of COPD (periodic escalations of symptoms of cough, dyspnea, and sputum production) is a major contributor to worsening lung function, impairment in quality of life, need for urgent care or hospitalization, and cost of care in COPD. Research conducted over the past decade has contributed much to our current understanding of the pathogenesis and treatment of COPD. Additionally, an evolving literature has accumulated about the prevention of acute exacerbations. METHODS: In recognition of the importance of preventing exacerbations in patients with COPD, the American College of Chest Physicians (CHEST) and Canadian Thoracic Society (CTS) joint evidence-based guideline (AECOPD Guideline) was developed to provide a practical, clinically useful document to describe the current state of knowledge regarding the prevention of acute exacerbations according to major categories of prevention therapies. Three key clinical questions developed using the PICO (population, intervention, comparator, and outcome) format addressed the prevention of acute exacerbations of COPD: nonpharmacologic therapies, inhaled therapies, and oral therapies. We used recognized document evaluation tools to assess and choose the most appropriate studies and to extract meaningful data and grade the level of evidence to support the recommendations in each PICO question in a balanced and unbiased fashion. RESULTS: The AECOPD Guideline is unique not only for its topic, the prevention of acute exacerbations of COPD, but also for the first-in-kind partnership between two of the largest thoracic societies in North America. The CHEST Guidelines Oversight Committee in partnership with the CTS COPD Clinical Assembly launched this project with the objective that a systematic review and critical evaluation of the published literature by clinical experts and researchers in the field of COPD would lead to a series of recommendations to assist clinicians in their management of the patient with COPD. CONCLUSIONS: This guideline is unique because it provides an up-to-date, rigorous, evidencebased analysis of current randomized controlled trial data regarding the prevention of COPD exacerbations. C1 [Criner, Gerard J.] Temple Univ, Sch Med, Philadelphia, PA 19140 USA. [Bourbeau, Jean] McGill Univ, Ctr Hlth, Resp Epidemiol & Clin Res Unit, Montreal Chest Inst, Montreal, PQ, Canada. [Diekemper, Rebecca L.; Ornelas, Joseph] Amer Coll Chest Phys, Glenview, IL USA. [Ouellette, Daniel R.] Henry Ford Hlth Syst, Detroit, MI USA. [Goodridge, Donna] Univ Saskatchewan, Coll Med, Saskatoon, SK S7N 0W0, Canada. [Hernandez, Paul] Dalhousie Univ, Dept Med, Halifax, NS, Canada. [Dechman, Gail] Dalhousie Univ, Sch Physiotherapy, Halifax, NS, Canada. [Curren, Kristen] Canadian Thorac Soc, Ottawa, ON, Canada. [Balter, Meyer S.] Univ Toronto, Div Respirol, Toronto, ON, Canada. [Bhutani, Mohit] Univ Alberta, Edmonton, AB, Canada. [Camp, Pat G.] Univ British Columbia, Dept Phys Therapy, Vancouver, BC V5Z 1M9, Canada. [Celli, Bartolome R.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA. [Dransfield, Mark T.] Univ Alabama Birmingham, Birmingham, AL USA. [Dransfield, Mark T.] Birmingham VA Med Ctr, Birmingham, AL USA. [Fiel, Stanley B.] Atlantic Hlth Syst, Med Ctr, Morristown, NJ USA. [Foreman, Marilyn G.] Morehouse Sch Med, Atlanta, GA 30310 USA. [Hanania, Nicola A.] Baylor Coll Med, Houston, TX 77030 USA. [Ireland, Belinda K.] TheEvidenceDoc LLC, Pacific, MO USA. [Marchetti, Nathaniel] Temple Univ, Sch Med, Philadelphia, PA USA. [Marciniuk, Darcy D.] Univ Saskatchewan, Royal Univ Hosp, Div Respirol Crit Care & Sleep, Saskatoon, SK, Canada. [Mularski, Richard A.] Kaiser Permanente Ctr Hlth Res, Portland, OR USA. [Road, Jeremy D.] Univ British Columbia, Dept Med, Vancouver, BC, Canada. [Stickland, Michael K.] Univ Alberta, Div Pulm Med, Edmonton, AB, Canada. RP Criner, GJ (reprint author), Temple Univ, Sch Med, Dept Pulm & Crit Care Med, 745 Parkinson Pavilion,3401 N Broad St, Philadelphia, PA 19140 USA. EM gerard.criner@tuhs.temple.edu OI Goodridge, Donna/0000-0002-8680-8646; Foreman, Marilyn/0000-0002-9405-7475 FU American College of Chest Physicians; Canadian Thoracic Society FX The American College of Chest Physicians and the Canadian Thoracic Society supported the development this article and the innovations addressed within. NR 284 TC 41 Z9 44 U1 7 U2 20 PU AMER COLL CHEST PHYSICIANS PI GLENVIEW PA 2595 PATRIOT BLVD, GLENVIEW, IL 60026 USA SN 0012-3692 J9 CHEST JI Chest PD APR PY 2015 VL 147 IS 4 BP 894 EP 942 DI 10.1378/chest.14-1676 PG 49 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA CI2VT UT WOS:000354606300022 PM 25321320 ER PT J AU Muellerova, H Maselli, DJ Locantore, N Vestbo, J Hurst, JR Wedzicha, JA Bakke, P Agusti, A Anzueto, A AF Muellerova, Hana Maselli, Diego J. Locantore, Nicholas Vestbo, Jorgen Hurst, John R. Wedzicha, Jadwiga A. Bakke, Per Agusti, Alvar Anzueto, Antonio CA ECLIPSE Investigators TI Hospitalized Exacerbations of COPD Risk Factors and Outcomes in the ECLIPSE Cohort SO CHEST LA English DT Article ID OBSTRUCTIVE PULMONARY-DISEASE; LUNG-FUNCTION DECLINE; QUALITY-OF-LIFE; HEALTH-STATUS; GLOBAL BURDEN; TIME-COURSE; MORTALITY; PREDICTORS; SEVERITY; RECOVERY AB OBJECTIVE: Exacerbations of COPD requiring hospital admission have important clinical and societal implications. We sought to investigate the incidence, recurrence, risk factors, and mortality of patients with COPD exacerbations requiring hospital admission compared with those without hospital admission during 3-year follow-up. Patients with COPD (N = 2,138) were identified from the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) observational cohort. METHODS: An analysis of time to first event of hospital admission was performed using Kaplan-Meier curves and Cox proportional hazard regression adjusting for possible confounders. RESULTS: Of the 2,138 patients, 670 (31%) reported a total of 1,452 COPD exacerbations requiring hospital admission during the study period; 313 patients (15%) reported multiple events. A prior history of exacerbation of COPD requiring hospital admission was the factor associated with the highest risk of a new hospitalization for exacerbation (hazard ratio, 2.71; 95% CI, 2.24-3.29; P < .001). Other risk factors included more severe airflow limitation, poorer health status, older age, radiologic evidence of emphysema, and higher WBC count. Having been hospitalized for exacerbation significantly increased the risk of mortality (P,.001). CONCLUSIONS: Exacerbations of COPD requiring hospital admission occur across all stages of airflow limitation and are a significant prognostic factor of reduced survival across all COPD stages. Patients with COPD at a high risk for hospitalization can be identified by their past history for similar events, and other factors, including the severity of airflow limitation, poor health status, age, presence of emphysema, and leukocytosis. C1 [Muellerova, Hana] GlaxoSmithKline R&D, Resp Epidemiol, Uxbridge, Middx, England. [Maselli, Diego J.; Anzueto, Antonio] South Texas Vet Hlth Care Syst, Audie L Murphy Hosp, San Antonio, TX USA. [Maselli, Diego J.; Anzueto, Antonio] Univ Texas Hlth Sci Ctr San Antonio, Crit Care Med, Div Pulm Dis, San Antonio, TX 78229 USA. [Locantore, Nicholas] GlaxoSmithKline, Resp Med Dev Ctr, Res Triangle Pk, NC USA. [Vestbo, Jorgen] Gentofte, Hellerup, Denmark. [Vestbo, Jorgen] Univ Manchester, Resp Res Grp, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England. [Hurst, John R.] UCL, Ctr Inflammat & Tissue Repair, London, England. [Wedzicha, Jadwiga A.] UCL, Ctr Resp Med, London, England. [Bakke, Per] Univ Bergen, Dept Clin Sci, Bergen, Norway. [Bakke, Per] Haukeland Hosp, Dept Thorac Med, N-5021 Bergen, Norway. [Agusti, Alvar] Univ Barcelona, Thorax Inst, Hosp Clin, IDIBAPS, Barcelona, Spain. [Agusti, Alvar] CIBER Enfermedades Resp, FISIB, Mallorca, Spain. RP Anzueto, A (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Div Pulm Crit Care Med, 7400 Merton Minter,MC111E, San Antonio, TX 78229 USA. EM anzueto@uthscsa.edu RI Agusti Garcia-Navarro, Alvar/F-4474-2015 OI Agusti Garcia-Navarro, Alvar/0000-0003-3271-3788; MacNee, William/0000-0002-3692-1448; Mullerova, Hana/0000-0002-0949-0101 FU GlaxoSmithKline FX The ECLIPSE study was funded by GlaxoSmithKline. NR 52 TC 21 Z9 21 U1 3 U2 7 PU AMER COLL CHEST PHYSICIANS PI GLENVIEW PA 2595 PATRIOT BLVD, GLENVIEW, IL 60026 USA SN 0012-3692 J9 CHEST JI Chest PD APR PY 2015 VL 147 IS 4 BP 999 EP 1007 DI 10.1378/chest.14-0655 PG 9 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA CI2VT UT WOS:000354606300029 ER PT J AU Chumbler, NR Li, XL Quigley, P Morey, MC Rose, D Griffiths, P Sanford, J Hoenig, H AF Chumbler, Neale R. Li, Xinli Quigley, Patricia Morey, Miriam C. Rose, Dorian Griffiths, Patricia Sanford, Jon Hoenig, Helen TI A randomized controlled trial on Stroke telerehabilitation: The effects on falls self-efficacy and satisfaction with care SO JOURNAL OF TELEMEDICINE AND TELECARE LA English DT Article DE Telemedicine; stroke; rehabilitation; satisfaction; falls; self-efficacy ID REHABILITATION; SINGAPORE; VETERANS; OUTCOMES AB We determined the effect of a multifaceted stroke telerehabilitation (STeleR) intervention on falls-related self-efficacy and satisfaction with care. We conducted a prospective, randomized, multisite, single-blinded trial in 52 veterans from three Veterans Affairs Medical Centers. Participants who experienced a stroke in the past 24 months were randomized to the STeleR intervention or usual care. Participants in the intervention arm were administered an exit interview to gather specific patient satisfaction data three months after their final outcome measure. The STeleR intervention consisted of three home visits, five telephone calls, and an in-home messaging device provided over three months to instruct patients in functionally based exercises and adaptive strategies. The outcome measures included Falls Efficacy Scale to measure fall-related self-efficacy and a Stroke-Specific Patient Satisfaction with Care (SSPSC) scale, a measure separated into two subscales (satisfaction with home care and satisfaction with hospital care) was employed to measure the participants' satisfaction. At six months, compared with the usual care group, the STeleR group showed statistically significant improvements in one of the two SSPSC scales (satisfaction with hospital care, p = .029) and approached significance in the second SSPSC scale (satisfaction with home care, p = .077). There were no improvements in fall-related self-efficacy. Core concepts identified were: (a) beneficial impact of the trained assistant; (b) exercises helpful; (c) home use of technology. The STeleR intervention improved satisfaction with care, especially as it relates to care following their experience from the hospital. With the limited resources available for in-home rehabilitation for stroke survivors, STeleR (and especially its exercise components) can be a useful complement to traditional post-stroke rehabilitation. C1 [Chumbler, Neale R.] Univ Georgia, Coll Publ Hlth, Dept Hlth Policy & Management, Athens, GA 30602 USA. [Li, Xinli] US Dept Vet Affairs, Natl Surg Off, Deputy Undersecretary Hlth & Operat & Management, Denver, CO USA. [Quigley, Patricia] HSR&D RRD Ctr Excellence, Maximizing Rehabil Outcomes, Tampa, FL USA. [Morey, Miriam C.] Durham VA Med Ctr, Geriatr Res Educ & Clin Ctr, Durham, NC USA. [Morey, Miriam C.] Duke Univ, Sch Med, Older Amer Independence Pepper Ctr, Durham, NC USA. [Rose, Dorian] Univ Florida, Coll Publ Hlth & Hlth Profess, Dept Phys Therapy, Gainesville, FL USA. [Griffiths, Patricia; Sanford, Jon] Ctr Visual & Neurocognit Rehabil, Atlanta Dept Vet Affairs RR&D, Atlanta, GA USA. [Griffiths, Patricia] GRECC, Dept Vet Affairs Birmingham Atlanta, Atlanta, GA USA. [Griffiths, Patricia] Emory Univ, Sch Med, Div Gen Med & Geriatr, Atlanta, GA 30322 USA. [Sanford, Jon] Georgia Tech Univ, Coll Architecture, Ctr Assist Technol & Environm Access, Atlanta, GA USA. [Hoenig, Helen] Duke Univ, Med Ctr, Durham, NC USA. [Hoenig, Helen] Durham VA Med Ctr, Phys Med & Rehabil Serv, Durham, NC USA. RP Chumbler, NR (reprint author), Univ Georgia, Coll Publ Hlth, Dept Hlth Policy & Management, Athens, GA 30602 USA. EM chumbler@uga.edu FU Department of Veterans Affairs Rehabilitation Research and Development (RRD) [B4492R] FX This research was supported by a grant from the Department of Veterans Affairs Rehabilitation Research and Development (RR&D) (B4492R). An earlier version of this paper was presented at the 2014 International Conference on Collaboration Technologies and Systems in Minneapolis, MN. The opinions contained in this paper are those of the authors and do not necessarily reflect those of the US Department of Veterans Affairs. NR 18 TC 0 Z9 0 U1 3 U2 8 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1357-633X EI 1758-1109 J9 J TELEMED TELECARE JI J. Telemed. Telecare PD APR PY 2015 VL 21 IS 3 BP 139 EP 143 DI 10.1177/1357633X15571995 PG 5 WC Health Care Sciences & Services SC Health Care Sciences & Services GA CI1UL UT WOS:000354530300003 PM 25680390 ER PT J AU Akiba, Y Kaunitz, JD Million, M AF Akiba, Yasutada Kaunitz, Jonathan D. Million, Mulugeta TI Peripheral Corticotropin-Releasing Factor Receptor Type 2 Activation Increases Colonic Blood Flow Through Nitric Oxide Pathway in Rats SO DIGESTIVE DISEASES AND SCIENCES LA English DT Article DE Colonic blood flow; Corticotropin-releasing factor; Mouse urocortin 2; Sauvagine; Astressin(2)-B; Nitric oxide ID STRESS-RELATED ALTERATIONS; ACID-SENSING PATHWAYS; FACTOR CRF FAMILY; UROTENSIN-I; PROSTAGLANDIN E-2; GASTRIC TRANSIT; SENSORY NEURONS; MUCOSAL DEFENSE; MOTOR FUNCTION; UROCORTIN-II AB Background Corticotropin-releasing factor (CRF) peptides exert profound effects on the secretomotor function of the gastrointestinal tract. Nevertheless, despite the presence of CRF peptides and receptors in colonic tissue, their influence on colonic blood flow (CBF) is unknown. Aim To determine the effect and mechanism of members of the CRF peptide family on CBF in isoflurane-anesthetized rats. Methods Proximal CBF was measured with laser-Doppler flowmetry simultaneously with mean arterial blood pressure (MABP) measurement. Rats were injected with intravenous human/rat CRF (CRF1 > CRF2 affinity), mouse urocortin 2 (mUcn2, selective CRF2 agonist), or sauvagine (SVG, CRF2 > CRF1 affinity) at 1-30 mu g/kg. The nitric oxide (NO) synthase inhibitor, L-NAME (3 mg/kg, iv), the cyclooxygenase inhibitor, indomethacin (Indo, 5 mg/kg, ip), or selective CRF2 antagonist, astressin(2)-B (Ast(2)B, 50 mu g/kg, iv) was given before SVG injection (10 mu g/kg, iv). Results SVG and mUcn2 dose-dependently increased CBF while decreasing MABP and colonic vascular resistance (CVR). CRF had no effect on CBF, but increased CVR. The hyperemic effect of SVG was inhibited by L-NAME but not by Indo, whereas hypotension was partially reduced by L-NAME. Sensory denervation had no effect on SVG-induced changes. Ast(2)B inhibited SVG-induced hyperemia and decreased CVR, and partially reduced the hypotension. Conclusions Peripheral CRF2 activation induces colonic hyperemia through NO synthesis, without involving prostaglandin synthesis or sensory nerve activation, suggesting a direct action on the endothelium and myenteric neurons. Members of the CRF peptide family may protect the colonic mucosa via the activation of the CRF2 receptor. C1 [Akiba, Yasutada; Kaunitz, Jonathan D.; Million, Mulugeta] Univ Calif Los Angeles, David Geffen Sch Med, Oppenheimer Family Ctr Neurobiol Stress, CURE Digest Dis Res Ctr, Los Angeles, CA 90095 USA. [Akiba, Yasutada; Kaunitz, Jonathan D.] VA Greater Los Angles Healthcare Syst, Los Angeles, CA 90073 USA. [Akiba, Yasutada; Kaunitz, Jonathan D.] Brentwood Biomed Res Inst, Los Angeles, CA 90073 USA. [Million, Mulugeta] VA Greater Los Angles Healthcare Syst, Los Angeles, CA 90073 USA. RP Million, M (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Oppenheimer Family Ctr Neurobiol Stress, CURE Digest Dis Res Ctr, Los Angeles, CA 90095 USA. EM yakiba@mednet.ucla.edu; jake@ucla.edu; mmuluget@ucla.edu FU NIHDDK [DK 57238-01A1S1, DK078676]; Department of Veterans Affairs Merit Review Award; NIH-NIDDK [RO1 DK54221]; [NIHDDK-41303] FX We would like to thank Dr. Yvette Tache (UCLA) and Dr. Jean Rivier (Salk Institute, Peptide Laboratories) for their suggestions and peptide supply. Authors received study support from NIHDDK-41303 Animal Model Core (MM, JDK), NIHDDK DK 57238-01A1S1 & DK078676 (MM), Department of Veterans Affairs Merit Review Award, and NIH-NIDDK RO1 DK54221 (JDK). NR 55 TC 2 Z9 2 U1 0 U2 5 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0163-2116 EI 1573-2568 J9 DIGEST DIS SCI JI Dig. Dis. Sci. PD APR PY 2015 VL 60 IS 4 BP 858 EP 867 DI 10.1007/s10620-015-3579-y PG 10 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA CI0YC UT WOS:000354464900014 PM 25701320 ER PT J AU Hernandez, R Kershaw, KN Prohaska, TR Wang, PC Marquez, DX Sarkisian, CA AF Hernandez, Rosalba Kershaw, Kiarri N. Prohaska, Thomas R. Wang, Pin-Chieh Marquez, David X. Sarkisian, Catherine A. TI The Cross-Sectional and Longitudinal Association Between Perceived Neighborhood Walkability Characteristics and Depressive Symptoms in Older Latinos: The "!Caminemos!" Study SO JOURNAL OF AGING AND HEALTH LA English DT Article DE older adults; Hispanics/Latinos; depressive symptoms; neighborhood/environment ID MENTAL-HEALTH-CARE; ETHNIC DISPARITIES; SOCIAL SUPPORT; 5-ITEM VERSION; ADULTS; SCALE; PREVALENCE; COMMUNITY; ENVIRONMENT; POPULATION AB Objective: Evaluate the cross-sectional and longitudinal association between perceived walkability-related neighborhood characteristics (e.g., traffic safety) and depressive symptoms among community-dwelling older Latino adults. Method: We used baseline, 12-month, and 24-month in-person interview data collected from Latinos aged >= 60 years participating in an exercise intervention at 27 senior centers (N = 570). Results: In cross-sectional analyses, lower perceived neighborhood crime, indicative of greater neighborhood walkability, was associated with a lower odds of elevated symptoms of depression (odds ratio [OR] = 0.90; 95% confidence interval [CI] = [0.82, 0.996]; p = .04) after adjusting for demographic characteristics, linguistic acculturation, and medical comorbidities. Associations between Neighborhood Environment Walkability scales and incident depressive symptoms at 12- and/or 24-months were not statistically significant, but the point estimate for crime safety was consistent with cross-sectional findings (OR = 0.83; 95% CI = [0.64, 1.07]; p = .16), suggesting a protective effect for lower perceived neighborhood crime. Discussion: Lower perceived neighborhood crime is associated with reduced presence of elevated symptoms of depression in older Latinos. C1 [Hernandez, Rosalba] Univ Illinois, Urbana, IL 61801 USA. [Kershaw, Kiarri N.] Northwestern Univ, Chicago, IL 60611 USA. [Prohaska, Thomas R.] George Mason Univ, Fairfax, VA 22030 USA. [Wang, Pin-Chieh; Sarkisian, Catherine A.] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA. [Marquez, David X.] Univ Illinois, Chicago, IL USA. [Sarkisian, Catherine A.] Vet Adm Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. RP Hernandez, R (reprint author), Univ Illinois, Sch Social Work, 1010 W Nevada St, Urbana, IL 61801 USA. EM rherna17@illinois.edu FU National Institute on Aging of the National Institutes of Health [R01 AG024460-05, P30AG028748, K24AG047899]; University of California, Los Angeles, Resource Centers for Minority Aging Research Center for Health Improvement of Minority Elderly (RCMAR/CHIME) under NIH/NIA Grant [P30-AG021684] FX The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Research reported in this publication was supported by the National Institute on Aging of the National Institutes of Health under Award Number R01 AG024460-05, P30AG028748 (UCLA Claude D. Pepper Older Americans Independence Center), and K24AG047899. University of California, Los Angeles, Resource Centers for Minority Aging Research Center for Health Improvement of Minority Elderly (RCMAR/CHIME) under NIH/NIA Grant P30-AG021684. Rosalba Hernandez was a T32 Post-Doctoral Fellow on NHLBI T32 HL 069771-10 (Daviglus, PI) when initially drafting this manuscript. NR 39 TC 4 Z9 4 U1 2 U2 6 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0898-2643 EI 1552-6887 J9 J AGING HEALTH JI J. Aging Health PD APR PY 2015 VL 27 IS 3 BP 551 EP 568 DI 10.1177/0898264314553211 PG 18 WC Gerontology; Health Policy & Services SC Geriatrics & Gerontology; Health Care Sciences & Services GA CI2BO UT WOS:000354549800008 PM 25326129 ER PT J AU Yu, Z Wang, R Fok, WC Coles, A Salmon, AB Perez, VI AF Yu, Zhen Wang, Rong Fok, Wilson C. Coles, Alexander Salmon, Adam B. Perez, Viviana I. TI Rapamycin and Dietary Restriction Induce Metabolically Distinctive Changes in Mouse Liver SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES LA English DT Article DE Rapamycin; Dietary restriction; Metabolites; beta-oxidation ID INDUCED INSULIN-RESISTANCE; FATTY-ACID-METABOLISM; CALORIC RESTRICTION; GLUCOSE-METABOLISM; LIFE-SPAN; SKELETAL-MUSCLE; SMOOTH-MUSCLE; MICE; ACTIVATION; SIROLIMUS AB Dietary restriction (DR) is the gold standard intervention used to delay aging, and much recent research has focused on the identification of possible DR mimetics. Energy sensing pathways, including insulin/IGF1 signaling, sirtuins, and mammalian Target of Rapamycin (mTOR), have been proposed as pathways involved in the antiaging actions of DR, and compounds that affect these pathways have been suggested to act as DR mimetics, including metformin (insulin/IGF1 signaling), resveratrol (sirtuins), and rapamycin (mTOR). Rapamycin is a promising DR mimetic because it significantly increases both health span and life span in mice. Unfortunately, rapamycin also leads to some negative effects, foremost among which is the induction of insulin resistance, potentially limiting its translation into humans. To begin clarifying the mechanism(s) involved in insulin resistance induced by rapamycin, we compared several aspects of liver metabolism in mice treated with DR or rapamycin for 6 months. Our data suggest that although both DR and rapamycin inhibit lipogenesis, activate lipolysis, and increased serum levels of nonesterified fatty acids, only DR further activates beta-oxidation of the fatty acids leading to the production of ketone bodies. C1 [Yu, Zhen; Wang, Rong; Perez, Viviana I.] Oregon State Univ, Linus Pauling Inst, Corvallis, OR 97331 USA. [Fok, Wilson C.] Univ Oklahoma, Hlth Sci Ctr, Dept Geriatr Med, Norman, OK 73019 USA. [Fok, Wilson C.] Oklahoma City VA Med Ctr, Oklahoma City, OK USA. [Coles, Alexander] Univ Michigan Flint, Dept Chem & Biochem, Flint, MI USA. [Salmon, Adam B.] South Texas Vet Hlth Care Syst, Dept Mol Med, San Antonio, TX USA. [Salmon, Adam B.] Barshop Inst Longev & Aging Studies, San Antonio, TX USA. [Salmon, Adam B.] Audie Murphy VA Hosp, South Texas Vet Hlth Care Syst, San Antonio, TX USA. [Perez, Viviana I.] Oregon State Univ, Dept Biochem & Biophys, Corvallis, OR 97331 USA. RP Perez, VI (reprint author), Oregon State Univ, Linus Pauling Inst, Dept Biochem & Biophys, Linus Pauling Sci Ctr 307, Corvallis, OR 97331 USA. EM viviana.perez@oregonstate.edu OI Fok, Wilson Chun Yim/0000-0003-3289-2093 FU National Institutional of Health (NIH) [AG036613]; San Antonio Nathan Shock Aging Center [1P30-AG-13319]; NIH [AG021890]; Ellison Medical Foundation; Department of Biochemistry and Biophysics; Linus Pauling Institute FX Financial support was provided by National Institutional of Health (NIH) RC2 Grand Opportunity grant (AG036613 to A.R.), The San Antonio Nathan Shock Aging Center (1P30-AG-13319 to A.R.), NIH T32 Training Grant (AG021890 to W.F.), and The Ellison Medical Foundation (V.I.P.), and start-up funds from the Department of Biochemistry and Biophysics and The Linus Pauling Institute (V.I.P.). NR 46 TC 5 Z9 5 U1 1 U2 12 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1079-5006 EI 1758-535X J9 J GERONTOL A-BIOL JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci. PD APR PY 2015 VL 70 IS 4 BP 410 EP 420 DI 10.1093/gerona/glu053 PG 11 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CH2ZW UT WOS:000353896100002 PM 24755936 ER PT J AU Saladin, ME McClure, EA Baker, NL Carpenter, MJ Ramakrishnan, V Hartwell, KJ Gray, KM AF Saladin, Michael E. McClure, Erin A. Baker, Nathaniel L. Carpenter, Matthew J. Ramakrishnan, Viswanathan Hartwell, Karen J. Gray, Kevin M. TI Increasing Progesterone Levels Are Associated With Smoking Abstinence Among Free-Cycling Women Smokers Who Receive Brief Pharmacotherapy SO NICOTINE & TOBACCO RESEARCH LA English DT Article ID NICOTINE REPLACEMENT THERAPY; COCAINE-SEEKING BEHAVIOR; LOCALLY WEIGHTED REGRESSION; MENSTRUAL-CYCLE; SEX-DIFFERENCES; FEMALE RATS; GENDER-DIFFERENCES; OVARIAN HORMONES; BIOLOGICAL BASIS; QUIT DATE AB Introduction: Preclinical and human laboratory research suggests that (a) progesterone may decrease drug reward, craving, and smoking behavior, and (b) estradiol may enhance drug reward and smoking behavior. A modest majority of treatment research examining the relationship between menstrual cycle phase and outcomes suggests that the luteal menstrual phase, with its uniquely higher progesterone levels, is associated with better cessation outcomes. However, no studies to date have examined the effects of naturally occurring variation in progesterone and estradiol levels on medication-assisted smoking cessation. The present study sought to fill this notable gap in the treatment literature. Methods: Weekly plasma progesterone and estradiol levels were obtained from nicotine-dependent female smokers enrolled in a 4-week cessation trial. Participants (N = 108) were randomized to receive a 4-week course of either varenicline (VAR) tablets and placebo patches or placebo tablets and nicotine patches. Plasma samples were obtained 1 week before their cessation attempt and weekly during medication administration. Abstinence was assessed weekly. Results: Weekly hormone data replicated commonly observed menstrual cycle patterns of progesterone and estradiol levels. Importantly, increases in progesterone level were associated with a 23% increase in the odds for being abstinent within each week of treatment. This effect was driven primarily by nicotine patch-treated versus VAR-treated females. Conclusions: This study was the first to identify an association between progesterone level (increasing) and abstinence outcomes in free-cycling women smokers who participated in a medicationbased treatment. Furthermore, the potential benefits of progesterone may vary across different pharmacotherapies. Implications of these findings for smoking cessation intervention are discussed. C1 [Saladin, Michael E.] Med Univ S Carolina, Dept Hlth Sci & Res, Charleston, SC 29425 USA. [Saladin, Michael E.; McClure, Erin A.; Carpenter, Matthew J.; Hartwell, Karen J.; Gray, Kevin M.] Med Univ S Carolina, Clin Neurosci Div, Charleston, SC 29425 USA. [Gray, Kevin M.] Med Univ S Carolina, Dept Psychiat & Behav Sci, Youth Div, Charleston, SC 29425 USA. [Carpenter, Matthew J.] Med Univ S Carolina, Hollings Canc Ctr, Charleston, SC 29425 USA. [Baker, Nathaniel L.; Ramakrishnan, Viswanathan] Med Univ S Carolina, Dept Publ Hlth Sci, Charleston, SC 29425 USA. [Hartwell, Karen J.] Ralph H Johnson Vet Affairs Med Ctr, Mental Hlth Serv, Subst Abuse Treatment Ctr, Charleston, SC USA. RP Saladin, ME (reprint author), Med Univ S Carolina, Dept Hlth Sci & Res, Coll Hlth Profess, 77 President St,Room 224,MSC700, Charleston, SC 29425 USA. EM saladinm@musc.edu FU NIDA/ORWH/FDA [P50 DA016511]; Specialized Center of Research (SCOR) on Sex and Gender Factors Affecting Women's Health; SouthCarolina Clinical and Translational Research (SCTR) Institute; academic home at the Medical University of South Carolina, through NIH [UL1 RR029882, UL1 TR000062] FX This research was supported by NIDA/ORWH/FDA grant P50 DA016511, Specialized Center of Research (SCOR) on Sex and Gender Factors Affecting Women's Health, and by the SouthCarolina Clinical and Translational Research (SCTR) Institute, with an academic home at the Medical University of South Carolina, through NIH grant numbers UL1 RR029882 and UL1 TR000062. Clinical Trials Registration clinicaltrials.gov identifier #NCT00664755. NR 61 TC 6 Z9 6 U1 2 U2 2 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1462-2203 EI 1469-994X J9 NICOTINE TOB RES JI Nicotine Tob. Res. PD APR PY 2015 VL 17 IS 4 BP 398 EP 406 DI 10.1093/ntr/ntu262 PG 9 WC Substance Abuse; Public, Environmental & Occupational Health SC Substance Abuse; Public, Environmental & Occupational Health GA CH3CC UT WOS:000353903000004 PM 25762749 ER PT J AU Ringman, JM Liang, LJ Zhou, Y Vangala, S Teng, E Kremen, S Wharton, D Goate, A Marcus, DS Farlow, M Ghetti, B McDade, E Masters, CL Mayeux, RP Rossor, M Salloway, S Schofield, PR Cummings, JL Buckles, V Bateman, R Morris, JC AF Ringman, John M. Liang, Li-Jung Zhou, Yan Vangala, Sitaram Teng, Edmond Kremen, Sarah Wharton, David Goate, Alison Marcus, Daniel S. Farlow, Martin Ghetti, Bernardino McDade, Eric Masters, Colin L. Mayeux, Richard P. Rossor, Martin Salloway, Stephen Schofield, Peter R. Cummings, Jeffrey L. Buckles, Virginia Bateman, Randall Morris, John C. CA Dominantly Inherited Alzheimer TI Early behavioural changes in familial Alzheimer's disease in the Dominantly Inherited Alzheimer Network SO BRAIN LA English DT Article DE behaviour; depression; Alzheimer; prodromal; familial ID MILD COGNITIVE IMPAIRMENT; PRESENILIN-1 MUTATION CARRIERS; DEPRESSIVE SYMPTOMS; NEUROPSYCHIATRIC SYMPTOMS; OLDER-ADULTS; DEMENTIA; PROGRESSION; ONSET; ASSOCIATION; DECLINE AB Ringman et al. characterize behavioural changes in individuals with preclinical and early familial Alzheimer's disease. Significant behavioural changes do not occur prior to cognitive decline but, in common with late-onset Alzheimer's disease, increased rates of depression, anxiety, apathy and other behavioural changes are seen early in manifest familial disease.Prior studies indicate psychiatric symptoms such as depression, apathy and anxiety are risk factors for or prodromal symptoms of incipient Alzheimer's disease. The study of persons at 50% risk for inheriting autosomal dominant Alzheimer's disease mutations allows characterization of these symptoms before progressive decline in a population destined to develop illness. We sought to characterize early behavioural features in carriers of autosomal dominant Alzheimer's disease mutations. Two hundred and sixty-one persons unaware of their mutation status enrolled in the Dominantly Inherited Alzheimer Network, a study of persons with or at-risk for autosomal dominant Alzheimer's disease, were evaluated with the Neuropsychiatric Inventory-Questionnaire, the 15-item Geriatric Depression Scale and the Clinical Dementia Rating Scale (CDR). Ninety-seven asymptomatic (CDR = 0), 25 mildly symptomatic (CDR = 0.5), and 33 overtly affected (CDR > 0.5) autosomal dominant Alzheimer's disease mutation carriers were compared to 106 non-carriers with regard to frequency of behavioural symptoms on the Neuropsychiatric Inventory-Questionnaire and severity of depressive symptoms on the Geriatric Depression Scale using generalized linear regression models with appropriate distributions and link functions. Results from the adjusted analyses indicated that depressive symptoms on the Neuropsychiatric Inventory-Questionnaire were less common in cognitively asymptomatic mutation carriers than in non-carriers (5% versus 17%, P = 0.014) and the odds of experiencing at least one behavioural sign in cognitively asymptomatic mutation carriers was lower than in non-carriers (odds ratio = 0.50, 95% confidence interval: 0.26-0.98, P = 0.042). Depression (56% versus 17%, P = 0.0003), apathy (40% versus 4%, P < 0.0001), disinhibition (16% versus 2%, P = 0.009), irritability (48% versus 9%, P = 0.0001), sleep changes (28% versus 7%, P = 0.003), and agitation (24% versus 6%, P = 0.008) were more common and the degree of self-rated depression more severe (mean Geriatric Depression Scale score of 2.8 versus 1.4, P = 0.006) in mildly symptomatic mutation carriers relative to non-carriers. Anxiety, appetite changes, delusions, and repetitive motor activity were additionally more common in overtly impaired mutation carriers. Similar to studies of late-onset Alzheimer's disease, we demonstrated increased rates of depression, apathy, and other behavioural symptoms in the mildly symptomatic, prodromal phase of autosomal dominant Alzheimer's disease that increased with disease severity. We did not identify any increased psychopathology in mutation carriers over non-carriers during the presymptomatic stage, suggesting these symptoms result when a threshold of neurodegeneration is reached rather than as life-long qualities. Unexpectedly, we found lower rates of depressive symptoms in cognitively asymptomatic mutation carriers. C1 [Ringman, John M.; Zhou, Yan; Teng, Edmond; Kremen, Sarah; Wharton, David] Univ Calif Los Angeles, Mary S Easton Ctr Alzheimers Dis Res, Los Angeles, CA 90095 USA. [Liang, Li-Jung; Vangala, Sitaram] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90024 USA. [Teng, Edmond] VA Greater Los Angeles Healthcare Syst, Neurobehav Serv, GRECC, Los Angeles, CA 90095 USA. [Goate, Alison] Icahn Sch Med Mt Sinai, Dept Neurosci, New York, NY 10029 USA. [Marcus, Daniel S.; Buckles, Virginia; Bateman, Randall; Morris, John C.] Washington Univ, Sch Med, Dept Neurol, Knight Alzheimers Dis Res Ctr, St Louis, MO 63108 USA. [Farlow, Martin] Indiana Univ, Dept Neurol, Indianapolis, IN 46202 USA. [Ghetti, Bernardino] Indiana Univ, Dept Pathol & Lab Med, Indianapolis, IN 46202 USA. [McDade, Eric] Univ Pittsburgh, Sch Med, Alzheimer Dis Res Ctr, Pittsburgh, PA 15213 USA. [Masters, Colin L.] Univ Melbourne, Florey Inst, Parkville, Vic 3010, Australia. [Mayeux, Richard P.] Columbia Univ, Coll Phys & Surg, New York, NY 10032 USA. [Rossor, Martin] UCL, Inst Neurol, Dementia Res Ctr, Dept Neurodegenerat, London WC1 3BG, England. [Salloway, Stephen] Brown Univ, Butler Hosp, Providence, RI 02906 USA. [Schofield, Peter R.] Neurosci Res Australia, Sydney, NSW 2031, Australia. [Schofield, Peter R.] Univ New S Wales, Sch Med Sci, Sydney, NSW 2052, Australia. [Cummings, Jeffrey L.] Cleveland Clin, Lou Ruvo Ctr Brain Hlth, Las Vegas, NV 89106 USA. RP Ringman, JM (reprint author), USC Dept Neurol, Memory & Aging Ctr, 1540 Alcazar St,CHP215, Los Angeles, CA 90033 USA. EM jringman@mednet.ucla.edu FU Dominantly Inherited Alzheimer Network (DIAN) - National Institute on Aging (NIA) [U19AG032438]; UCLA Alzheimer's Disease Research Center Grant [P50 AG-16570]; UCLA Clinical Translational Research Institute [1UL1-RR033176]; Easton Consortium for Alzheimer's Disease Drug Discovery and Biomarker Development; NIHR Queen Square Dementia BRU FX Study supported by: Data collection and sharing for this project was supported by The Dominantly Inherited Alzheimer Network (DIAN, U19AG032438) funded by the National Institute on Aging (NIA). Further support for this work comes from the UCLA Alzheimer's Disease Research Center Grant P50 AG-16570, the UCLA Clinical Translational Research Institute 1UL1-RR033176, the Easton Consortium for Alzheimer's Disease Drug Discovery and Biomarker Development, and the NIHR Queen Square Dementia BRU. NR 36 TC 13 Z9 13 U1 2 U2 17 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0006-8950 EI 1460-2156 J9 BRAIN JI Brain PD APR 1 PY 2015 VL 138 BP 1036 EP 1045 DI 10.1093/brain/awv004 PN 4 PG 10 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA CG7XZ UT WOS:000353522100027 PM 25688083 ER PT J AU Bhalla, P Forrest, GN Gershon, M Zhou, Y Chen, J LaRussa, P Steinberg, S Gershon, AA AF Bhalla, Preeti Forrest, Graeme N. Gershon, Michael Zhou, Yan Chen, Jason LaRussa, Philip Steinberg, Sharon Gershon, Anne A. TI Disseminated, Persistent, and Fatal Infection Due to the Vaccine Strain of Varicella-Zoster Virus in an Adult Following Stem Cell Transplantation SO CLINICAL INFECTIOUS DISEASES LA English DT Editorial Material DE zoster; vOka; varicella; vaccine; granulomas ID KILLER T-CELLS; HERPES-ZOSTER; CUTANEOUS REACTIONS; NERVOUS-SYSTEM; SAFETY PROFILE; PATIENT; DEFICIENCY; CHILD; COMPLICATIONS; GRANULOMAS AB Live attenuated varicella vaccine is recommended for healthy individuals who are susceptible to varicella. Although the vaccine is safe, effective, and used worldwide, serious adverse events have been reported, mainly in immunocompromised patients who subsequently recovered. Here, we describe the fatality of an immunocompromised patient who received the varicella vaccine. His medical history provides a cautionary lens through which to view the decision of when vaccination is appropriate. A middle-aged man with non-Hodgkin lymphoma received chemotherapy and a stem cell transplant. He was vaccinated 4 years post-transplantation, despite diagnosis of a new low-grade lymphoma confined to the lymph nodes. Within 3 months of vaccination, he developed recurrent rashes with fever, malaise, weakness, hepatitis, weight loss, and renal failure. The syndrome was eventually determined to be associated with persistent disseminated zoster caused by the vaccine virus. This case illustrates a circumstance when a live viral vaccine should not be used. C1 [Bhalla, Preeti; Forrest, Graeme N.] Oregon Hlth & Sci Univ, Dept Med, Portland, OR USA. [Forrest, Graeme N.] Portland VA Med Ctr, Portland, OR USA. [Gershon, Michael; Zhou, Yan; Chen, Jason] Columbia Univ Coll Phys & Surg, Dept Pathol & Cell Biol, New York, NY 10032 USA. [LaRussa, Philip; Steinberg, Sharon; Gershon, Anne A.] Columbia Univ Coll Phys & Surg, Dept Pediat, New York, NY 10032 USA. RP Gershon, AA (reprint author), Columbia Univ Coll Phys & Surg, 630 W 168th St, New York, NY 10032 USA. EM aag1@cumc.columbia.edu FU NIDDK NIH HHS [R01 DK093094] NR 40 TC 11 Z9 11 U1 0 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD APR 1 PY 2015 VL 60 IS 7 BP 1068 EP 1074 DI 10.1093/cid/ciu970 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CH0MH UT WOS:000353714000013 PM 25452596 ER PT J AU van Koeverden, I Blanc, PD Bowler, RP Arjomandi, M AF van Koeverden, Ian Blanc, Paul D. Bowler, Russell P. Arjomandi, Mehrdad TI Secondhand Tobacco Smoke and COPD Risk in Smokers: A COPDGene Study Cohort Subgroup Analysis SO COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE LA English DT Article DE COPD; secondhand tobacco smoke; occupational exposure; job exposure matrix; cigarette smoking; work-related ID OBSTRUCTIVE PULMONARY-DISEASE; JOB-EXPOSURE MATRIX; OCCUPATIONAL-EXPOSURE; BURDEN; ADULTS; ASTHMA; OUTCOMES; DESIGN; IMPACT; FUMES AB Background: Exposure to secondhand tobacco smoke (SHS) can be a risk factor for chronic obstructive pulmonary disease (COPD), but its role among relatively heavy smokers with potential co-exposure to workplace vapors, gas, dust, and fumes (VGDF) has not been studied. Methods: To estimate the contribution of SHS exposure to COPD risk, taking into account smoking effects and work-related exposures to VGDF, we quantified SHS based on survey responses for 1400 ever-employed subjects enrolled in the COPDGene study, all current or former smokers with or without COPD. Occupational exposures to VGDF were quantified based on a job exposure matrix. The associations between SHS and COPD were tested in multivariate logistic regression analyses adjusted for age, sex, VGDF exposure, and cumulative smoking. Results and Discussion: Exposures to SHS at work and at home during adulthood were associated with increased COPD risk: odds ratio (OR) = 1.12 (95% confidence interval [CI]: 1.02-1.23; p = 0.01) and OR = 1.09 (95% CI: 1.00-1.18; p = 0.04) per 10 years of exposure adjusted for smoking and other covariates, respectively. In addition, subjects with employment histories likely to entail exposure to VGDF were more likely to have COPD: OR = 1.52 (95% CI: 1.16-1.98; p < 0.01) (adjusted for other covariates). While adult home SHS COPD risk was attenuated among the heaviest smokers within the cohort, workplace SHS and job VGDF risks persisted in that stratum. Conclusion: Among smokers all with at least 10 pack-years, adult home and work SHS exposures and occupational VGDF exposure are all associated with COPD. C1 [van Koeverden, Ian] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands. [van Koeverden, Ian; Arjomandi, Mehrdad] San Francisco VA Med Ctr, Pulm Res Grp, San Francisco, CA USA. [Blanc, Paul D.] Univ Calif San Francisco, Dept Med, Div Occupat & Environm Med, San Francisco, CA 94121 USA. [Blanc, Paul D.; Arjomandi, Mehrdad] Univ Calif San Francisco, Dept Med, Div Pulm Crit Care Allergy & Immunol & Sleep Med, San Francisco, CA 94121 USA. [Bowler, Russell P.] Natl Jewish Hlth, Denver, CO USA. RP Arjomandi, M (reprint author), Univ Calif San Francisco, San Francisco Vet Affairs Med Ctr, Div Pulm Crit Care Allergy & Immunol & Sleep Med, Bldg 203,Room 3A-128,Mailstop 111-D, San Francisco, CA 94121 USA. EM mehrdad.arjomandi@ucsf.edu FU NHLBI [U01 HL08-9856, U01 HL08-9897, K23 HL08-3099]; NCRR/HIH [UL1 RR025780]; Butcher Foundation; Flight Attendants Medical Research Institute (FAMRI) FX We would like to thank Dr. John Hokanson from University of Colorado Health Sciences with help in preparation of manuscript. Authors' contributions were as follows. Conceived and designed the experiment: RB. Collected data: RB. Designed analytical approach: MA, PB. Analyzed and interpreted the data: IvK, MA, PB. Wrote the manuscript: IvK, MA. Provided feedback on analyses and manuscript: PB, RB. Guarantor of the manuscript: MA, RB. The authors do not have any conflict of interest to disclose. This study was supported by NHLBI (U01 HL08-9856, U01 HL08-9897, Arjomandi K23 HL08-3099), NCRR/HIH (UL1 RR025780), the Butcher Foundation, and the Flight Attendants Medical Research Institute (FAMRI). The sponsors of the study had no role in the design and conduct of this study. NR 31 TC 0 Z9 0 U1 0 U2 0 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1541-2555 EI 1541-2563 J9 COPD JI COPD-J. Chronic Obstr. Pulm. Dis. PD APR PY 2015 VL 12 IS 2 BP 182 EP 189 DI 10.3109/15412555.2014.922173 PG 8 WC Respiratory System SC Respiratory System GA CH3JB UT WOS:000353925900010 ER PT J AU Marshall, MR Young, BA Fox, SJ Cleland, CJ Walker, RJ Maskane, I Herold, AM AF Marshall, Mark R. Young, Bessie A. Fox, Sally J. Cleland, Calli J. Walker, Robert J. Maskane, Ikuto Herold, Aaron M. TI The home hemodialysis hub: Physical infrastructure and integrated governance structure SO HEMODIALYSIS INTERNATIONAL LA English DT Article DE Infrastructure; governance; home hemodialysis; dialysis ID EXPERIENCE; DIALYSIS; PROGRAM; CHRISTCHURCH; BARRIERS AB An effective home hemodialysis program critically depends on adequate hub facilities and support functions and on transparent and accountable organizational processes. The likelihood of optimal service delivery and patient care will be enhanced by fit-for-purpose facilities and implementation of a well-considered governance structure. In this article, we describe the required accommodation and infrastructure for a home hemodialysis program and a generic organizational structure that will support both patient-facing clinical activities and business processes. C1 [Marshall, Mark R.] Univ Auckland, Fac Med & Hlth Sci, Auckland 1142, New Zealand. [Marshall, Mark R.; Fox, Sally J.; Cleland, Calli J.] Counties Manukau Dist Hlth Board, Dept Renal Med, Auckland, New Zealand. [Young, Bessie A.] Univ Washington, Div Nephrol, Kidney Res Inst, Vet Affairs Puget Sound Hlth Care Syst, Seattle, WA 98195 USA. [Walker, Robert J.] Univ Otago, Dunedin Sch Med, Dept Med, Dunedin, New Zealand. [Maskane, Ikuto] Yabuki Hosp, Kidney & Dialysis Ctr, Yamagata, Japan. [Herold, Aaron M.] Northwest Kidney Ctr, Operat Support, Seattle, WA USA. RP Marshall, MR (reprint author), Univ Auckland, Fac Med & Hlth Sci, Private Bag 92019, Auckland 1142, New Zealand. EM mrmarsh@woosh.co.nz FU Baxter; Fresenius Medical Care, Asia-Pacific; Auckland Medical Research Foundation; Gambro Pty Ltd (New Zealand); Fresenius Medical Care Australia Pty Ltd; Fresenius Medical Care Asia-Pacific Pty Ltd; Health Research Council of New Zealand; Kidney Health New Zealand; Lottery Health Research Foundation (New Zealand); Maurine and Phyllis Paykel Trust; New Zealand Ministry of Health; Royal Australasian College of Physicians Jacquot Foundation; Amgen; Ineos Healthcare Limited; Fresenius Medical Care FX MM is currently employed as the Director of Medical Affairs, Asia-Pacific, by Baxter Healthcare Corporation and previously served as a paid consultant to Baxter and Fresenius Medical Care, Asia-Pacific. He has received grant support from the Auckland Medical Research Foundation, Gambro Pty Ltd (New Zealand), Fresenius Medical Care Australia Pty Ltd, Fresenius Medical Care Asia-Pacific Pty Ltd, Health Research Council of New Zealand, Kidney Health New Zealand (formerly the National Kidney Foundation, New Zealand), Lottery Health Research Foundation (New Zealand), Maurine and Phyllis Paykel Trust, New Zealand Ministry of Health, and The Royal Australasian College of Physicians Jacquot Foundation. He has been an investigator for clinical trials sponsored by Amgen, Ineos Healthcare Limited, and Fresenius Medical Care. NR 25 TC 1 Z9 1 U1 2 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1492-7535 EI 1542-4758 J9 HEMODIAL INT JI Hemodial. Int. PD APR PY 2015 VL 19 SU 1 SI SI BP S8 EP S22 DI 10.1111/hdi.12273 PG 15 WC Urology & Nephrology SC Urology & Nephrology GA CH3WC UT WOS:000353960400003 PM 25925827 ER PT J AU Rao, MN Neylan, TC Grunfeld, C Mulligan, K Schambelan, M Schwarz, JM AF Rao, Madhu N. Neylan, Thomas C. Grunfeld, Carl Mulligan, Kathleen Schambelan, Morris Schwarz, Jean-Marc TI Subchronic Sleep Restriction Causes Tissue-Specific Insulin Resistance SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM LA English DT Article ID FATTY-ACID-METABOLISM; GLUCOSE-PRODUCTION; CARBOHYDRATE-METABOLISM; INFECTED PATIENTS; HUMANS; LIPOLYSIS; STIMULATION; SENSITIVITY; SECRETION; CORTISOL AB Context: Short sleep duration is associated with an increased risk of type 2 diabetes. Subchronic sleep restriction (SR) causes insulin resistance, but the mechanisms and roles of specific tissues are unclear. Objective: The purpose of this article was to determine whether subchronic SR altered (1) hepatic insulin sensitivity, (2) peripheral insulin sensitivity, and (3) substrate utilization. Design: This was a randomized crossover study in which 14 subjects underwent 2 admissions separated by a washout period. Each admission had 2 acclimatization nights followed by 5 nights of either SR (4 hours time in bed) or normal sleep (8 hours time in bed). Main Outcome Measure/Methods: Insulin sensitivity (measured by hyperinsulinemic-euglycemic clamp) and hepatic insulin sensitivity (measured by stable isotope techniques) were measured. In addition, we assayed stress hormone (24-hour urine free cortisol, metanephrine, and normetanephrine), nonesterified fatty acid (NEFA), and beta-hydroxybutyrate (beta-OH butyrate) levels. Resting energy expenditure (REE) and respiratory quotient (RQ) were measured by indirect calorimetry. Results: Compared to normal sleep, whole-body insulin sensitivity decreased by 25% (P = .008) with SR and peripheral insulin sensitivity decreased by 29% (P = .003). Whereas hepatic insulin sensitivity (endogenous glucose production) did not change significantly, percent gluconeogenesis increased (P = .03). Stress hormones increased modestly (cortisol by 21%, P = .04; metanephrine by 8%, P = .014; normetanephrine by 18%, P = .002). Fasting NEFA and beta-OH butyrate levels increased substantially (62% and 55%, respectively). REE did not change (P = 0.98), but RQ decreased (0.81 +/- .02 vs 0.75 +/- 0.02, P = .045). Conclusion: Subchronic SR causes unique metabolic disturbances characterized by peripheral, but not hepatic, insulin resistance; this was associated with a robust increase in fasting NEFA levels (indicative of increased lipolysis), decreased RQ, and increased beta-OH butyrate levels (indicative of whole-body and hepatic fat oxidation, respectively). We postulate that elevated NEFA levels are partially responsible for the decrease in peripheral sensitivity and modulation of hepatic metabolism (ie, increase in gluconeogenesis without increase in endogenous glucose production). Elevated cortisol and metanephrine levels may contribute to insulin resistance by increasing lipolysis and NEFA levels. C1 [Rao, Madhu N.; Neylan, Thomas C.; Grunfeld, Carl] San Francisco VA Med Ctr, San Francisco, CA 94121 USA. [Rao, Madhu N.; Grunfeld, Carl; Mulligan, Kathleen; Schambelan, Morris; Schwarz, Jean-Marc] Univ Calif San Francisco, Dept Med, Div Endocrinol & Metab, San Francisco, CA 94143 USA. [Neylan, Thomas C.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA. [Schwarz, Jean-Marc] Touro Univ, Vallejo, CA 94592 USA. RP Rao, MN (reprint author), San Francisco VA Med Ctr, 111F,4150 Clement St, San Francisco, CA 94121 USA. EM madhu.rao@ucsf.edu FU National Institutes of Health (National Heart, Lung, and Blood Institute Grant) [K23HL096832]; National Institutes of Health (National Center for Research Resources Grant) [UL 1 TR000004] FX This work was supported by funding from the National Institutes of Health (National Heart, Lung, and Blood Institute Grant K23HL096832, National Center for Research Resources Grant UL 1 TR000004) and with resources and the use of the facilities of the San Francisco Veterans' Affairs Medical Center NR 38 TC 13 Z9 13 U1 1 U2 6 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0021-972X EI 1945-7197 J9 J CLIN ENDOCR METAB JI J. Clin. Endocrinol. Metab. PD APR PY 2015 VL 100 IS 4 BP 1664 EP 1671 DI 10.1210/jc.2014-3911 PG 8 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA CG5UN UT WOS:000353361500078 PM 25658017 ER PT J AU Ma, C Hernandez, MA Kirkpatrick, VE Liang, LJ Nouvong, AL Gordon, IL AF Ma, Christine Hernandez, Michael A. Kirkpatrick, Vincent E. Liang, Li-Jung Nouvong, Aksone L. Gordon, Ian L. TI Topical Platelet-Derived Growth Factor vs Placebo Therapy of Diabetic Foot Ulcers Offloaded With Windowed Casts: A Randomized, Controlled Trial SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE LA English DT Article DE diabetic foot ulcer; platelet derived growth factor; diabetes; short leg walking cast ID OFF-LOADING DEVICES; TOTAL CONTACT CAST; LOWER-EXTREMITY; PLANTAR ULCERS; CLINICAL-TRIAL; BEARING CAST; ULCERATION; METAANALYSIS; DEBRIDEMENT; MANAGEMENT AB Objective. This study sought to compare the efficacy of topical platelet derived growth factor (Regranex, Smith and Nephew, London, UK) (test group) to placebo (control group) in treating diabetic foot ulcers. All subjects had a short leg walking cast with a window fashioned in the cast over the site of the ulcer. Methods. Forty-six subjects were randomized (double-blind) 1:1 to the test or control group and treated for up to 4 months. Subjects had Wagner grade I ulcers with wound area of 1 cm(2) to 16 cm(2) without severe peripheral arterial disease, osteomyelitis, or any infection requiring antibiotics. Study medication was applied daily and casts changed approximately every 14 days. Results. Of the 46 subjects randomized, 38 either healed or completed 16 weeks of therapy without healing. Eight subjects dropped out prior to 16 weeks. Based on intention-to-treat, 12 of 23 (52%) test group subjects healed before 16 weeks compared to 13 of 23 (57%) control group subjects (not significant). Regression analysis demonstrated that slower healing was associated with larger initial wound size (hazard radio [HR] = 0.997, 95% confidence interval [Cl]: 0.995-1.00, P = 0.028) and excessive wound drainage (HR = 0.346, 95% CI: 0.126-0.948, P = 0.039). Excluding the patients who dropped out, 25 of 38 (66%) subjects healed by 4 months. Three additional subjects healed with casts that were worn longer than 4 months, for an overall rate of 74% at 9 months. Five subjects developed cast burns, and 3 patients required amputation. Conclusion. Topical platelet derived growth factor does not appear to significantly improve healing of Wagner grade I diabetic foot ulcers that are treated by offloading with a short leg walking cast. Excellent healing rates may be achieved with casting alone. C1 [Ma, Christine; Hernandez, Michael A.; Kirkpatrick, Vincent E.; Gordon, Ian L.] Vet Affairs Long Beach Healthcare Syst, Dept Surg, Long Beach, CA USA. [Kirkpatrick, Vincent E.; Gordon, Ian L.] Univ Calif Irvine, Sch Med, Dept Surg, Orange, CA 92868 USA. [Liang, Li-Jung; Nouvong, Aksone L.] Vet Affairs Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. [Liang, Li-Jung; Nouvong, Aksone L.] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA. [Nouvong, Aksone L.] Westem Univ Hlth Sci, Pomona, CA USA. RP Kirkpatrick, VE (reprint author), Univ Calif Irvine, Med Ctr, Dept Surg, 333 City Blvd W,Suite 700, Orange, CA 92868 USA. EM kirkpatrickv@uthscsa.edu FU Heritage Medical Research Institute of Heritage Provider Network, Inc, Northridge, CA, a health maintenance organization FX The authors disclose this study was funded by the Heritage Medical Research Institute of Heritage Provider Network, Inc, Northridge, CA, a health maintenance organization whose research arm supports medical research. The sponsor had no influence on the collection and interpretation of data or the writing of the manuscript. NR 26 TC 7 Z9 7 U1 0 U2 5 PU H M P COMMUNICATIONS PI MALVERN PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA SN 1044-7946 EI 1943-2704 J9 WOUNDS JI Wounds-Compend. Clin. Res. Pract. PD APR PY 2015 VL 27 IS 4 BP 83 EP 91 PG 9 WC Dermatology; Surgery SC Dermatology; Surgery GA CG9XF UT WOS:000353672700002 PM 25855851 ER PT J AU Ana, EJS Prisciandaro, JJ Saladin, ME McRae-Clark, AL Shaftman, SR Nietert, PJ Brady, KT AF Ana, Elizabeth J. Santa Prisciandaro, James J. Saladin, Michael E. McRae-Clark, Aimee L. Shaftman, Stephanie R. Nietert, Paul J. Brady, Kathleen T. TI D-Cycloserine Combined With Cue Exposure Therapy Fails to Attenuate Subjective and Physiological Craving in Cocaine Dependence SO AMERICAN JOURNAL ON ADDICTIONS LA English DT Article ID CONDITIONED PLACE PREFERENCE; EXTINCTION; INDIVIDUALS; DISORDER; RECEPTOR; FEAR AB Background: Based on preclinical studies showing that the partial N-methyl-D-aspartate (NMDA) agonist D-cycloserine (DCS) facilitates extinction of cocaine self-administration and cocaine-induced conditioned place preference, we evaluated whether 50 mg of DCS would reduce craving to cocaine cues when combined with cue exposure (CE) in cocaine dependent humans. Methods: In this double-blind placebo-controlled pilot study, 47 cocaine dependent participants were randomized to DCS or placebo (PBO), plus CE. Participants received DCS or PBO 30 minutes prior to two CE sessions, conducted one day apart. Craving and heart rate was assessed prior to CE sessions, during CE trials, and after CE trials. These measures were assessed again at a 1-week follow-up (session 3) after the second CE session. Results: DCS failed to significantly attenuate cocaine cue reactivity based on subjective craving and physiological reactivity (heart rate) compared to PBO. The CE protocol, consisting of repeated exposure to drug cues combined with skills training, resulted in extinction to cocaine cues as suggested by decreased craving within and between sessions in both treatment conditions. All participants exhibited elevated heart rate with repeated exposures, demonstrating a potentiation in heart rate between sessions. Conclusions: 50 mg of DCS may not be effective for extinguishing reactivity to drug cues for individuals with cocaine dependence. Scientific Significance: Future studies examining the effect of DCS on facilitating extinction to drug cues should examine variations in cue exposure length, number of CE presentations, and timing of DCS dose administration prior to cue exposures, which may differentially impact drug cue reactivity. C1 [Ana, Elizabeth J. Santa; Prisciandaro, James J.; McRae-Clark, Aimee L.; Brady, Kathleen T.] Med Univ S Carolina, Dept Psychiat & Behav Sci, Div Clin Neurosci, Charleston, SC 29401 USA. [Ana, Elizabeth J. Santa] Ralph H Johnson VA Med Ctr, Charleston, SC USA. [Saladin, Michael E.] Med Univ S Carolina, Dept Hlth Sci & Res, Charleston, SC 29401 USA. [Shaftman, Stephanie R.; Nietert, Paul J.] Med Univ S Carolina, Dept Publ Hlth Sci, Charleston, SC 29401 USA. RP Ana, EJS (reprint author), Med Univ S Carolina, Dept Psychiat, Clin Neurosci Div, 109 Bee St, Charleston, SC 29401 USA. EM santaana@musc.edu FU National Institutes of Health [1R01DA023188-01A1, 3 R01 DA023188-02S1]; South Carolina Clinical and Translational Institute [UL1TR4000062] FX This study was supported by the National Institutes of Health (Grant Nos. 1R01DA023188-01A1 and 3 R01 DA023188-02S1) and the South Carolina Clinical and Translational Institute, UL1TR4000062. NR 43 TC 2 Z9 2 U1 0 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1055-0496 EI 1521-0391 J9 AM J ADDICTION JI Am. J. Addict. PD APR PY 2015 VL 24 IS 3 BP 217 EP 224 DI 10.1111/ajad.12191 PG 8 WC Substance Abuse SC Substance Abuse GA CG6MC UT WOS:000353414300007 ER PT J AU Duffy, SA Noonan, D Karvonen-Gutierrez, CA Ronis, DL Ewing, LA Waltje, AH Dalack, GW Smith, PM Carmody, TP Hicks, T Hermann, C AF Duffy, Sonia A. Noonan, Devon Karvonen-Gutierrez, Carrie A. Ronis, David L. Ewing, Lee A. Waltje, Andrea H. Dalack, Gregory W. Smith, Patricia M. Carmody, Timothy P. Hicks, Thomas Hermann, Christopher TI Effectiveness of the Tobacco Tactics Program for Psychiatric Inpatient Veterans: An Implementation Study SO ARCHIVES OF PSYCHIATRIC NURSING LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; RANDOMIZED CONTROLLED-TRIAL; MENTAL-HEALTH-CARE; SMOKING-CESSATION; NICOTINE DEPENDENCE; QUIT SMOKING; MOTIVATION; ADDICTION; ILLNESS; SMOKERS AB Background: The objective of this study was to evaluate the effectiveness of the inpatient, nurse-administered Tobacco Tactics program for patients admitted for psychiatric conditions in two Veterans Affairs (VA) hospitals compared to a control hospital. Methods: This is a subgroup analysis of data from the inpatient tobacco tactics effectiveness trial, which was a longitudinal, pre-post-nonrandomized comparison design with 6-month follow-up in the three large Veterans Integrated Service Networks (VISN) 11 hospitals. Results: Six-month self-reported quit rates for patients admitted for psychiatric conditions increased from 3.5% pre-intervention to 10.2% post-intervention compared to a decrease in self-reported quit rates in the control hospital (12% pre-intervention to 1.6% post-intervention). There was significant improvement in self-reported quit rates for the pre-versus post-intervention time periods in the Detroit and Ann Arbor intervention sites compared to the Indianapolis control site (P = 0.01) and cotinine results were in the same direction. Conclusion: The implementation of the Tobacco Tactics intervention has the potential to significantly decrease smoking and smoking-related morbidity and mortality among smokers admitted to VA hospitals for psychiatric disorders. Published by Elsevier Inc. C1 [Duffy, Sonia A.; Karvonen-Gutierrez, Carrie A.; Ewing, Lee A.] Ann Arbor VA Ctr Clin Management Res Hlth Serv Re, Ann Arbor, MI USA. [Duffy, Sonia A.] Ohio State Univ, Coll Nursing, Columbus, OH 43210 USA. [Ronis, David L.; Waltje, Andrea H.] Univ Michigan, Sch Nursing, Ann Arbor, MI 48109 USA. [Duffy, Sonia A.; Dalack, Gregory W.] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA. [Noonan, Devon] Duke Univ, Sch Nursing, Durham, NC USA. [Smith, Patricia M.] Northern Ontario Sch Med, Thunder Bay, ON, Canada. [Carmody, Timothy P.] San Francisco VA Med Ctr, San Francisco, CA USA. [Hicks, Thomas] Richard L Roudebush VA Med Ctr, Indianapolis, IN USA. [Hermann, Christopher] John D Dingell VA Med Ctr, Detroit, MI USA. RP Duffy, SA (reprint author), 2215 Fuller Rd, Ann Arbor, MI 48105 USA. EM bump@umich.edu FU Department of Veterans Affairs Service Directed Project [SDP 06-003] FX First and foremost, the authors would like to express our heartfelt appreciation to the Ann Arbor and Detroit nurses and other staff who included the intervention in their already busy work schedules. The study could not have been accomplished without the hard work of our research partners (Pamela Reeves, Petra Flanagan, Richard White, and Stacey Breedveld), research nurses (Amanda Fore, Judy Heath, and Carmelite Dalmacy), and research assistants (Wanda Hines and Elizabeth Jones). Most importantly, we would like to thank the Veterans that participated in this study. Funding was supported by the Department of Veterans Affairs Service Directed Project (SDP 06-003). NR 28 TC 0 Z9 0 U1 3 U2 6 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0883-9417 EI 1532-8228 J9 ARCH PSYCHIAT NURS JI Arch. Psychiatr. Nurs. PD APR PY 2015 VL 29 IS 2 BP 120 EP 126 DI 10.1016/j.apnu.2014.12.002 PG 7 WC Nursing; Psychiatry SC Nursing; Psychiatry GA CG5WR UT WOS:000353367100009 PM 25858205 ER PT J AU Wells, JM Iyer, AS Rahaghi, FN Bhatt, SP Gupta, H Denney, TS Lloyd, SG Dell'Italia, LJ Nath, H Estepar, RSJ Washko, GR Dransfield, MT AF Wells, J. Michael Iyer, Anand S. Rahaghi, Farbod N. Bhatt, Surya P. Gupta, Himanshu Denney, Thomas S. Lloyd, Steven G. Dell'Italia, Louis J. Nath, Hrudaya Estepar, Raul San Jose Washko, George R. Dransfield, Mark T. TI Pulmonary Artery Enlargement Is Associated With Right Ventricular Dysfunction and Loss of Blood Volume in Small Pulmonary Vessels in Chronic Obstructive Pulmonary Disease SO Circulation-Cardiovascular Imaging LA English DT Article DE cardiac magnetic resonance imaging; hypertension, pulmonary; pulmonary disease; pulmonary heart disease; smoking ID CARDIAC MAGNETIC-RESONANCE; EXERCISE PERFORMANCE; COMPUTED-TOMOGRAPHY; LOBE SEGMENTATION; PERCENT EMPHYSEMA; CONTROLLED-TRIAL; SEVERE COPD; HYPERTENSION; LUNG; ECHOCARDIOGRAPHY AB Background-Chronic obstructive pulmonary disease causes significant morbidity and concomitant pulmonary vascular disease and cardiac dysfunction are associated with poor prognosis. Computed tomography-detected relative pulmonary artery (PA) enlargement defined as a PA to ascending aorta diameter ratio >1 (PA:A>1) is a marker for pulmonary hypertension and predicts chronic obstructive pulmonary disease exacerbations. However, little is known about the relationship between the PA: A ratio, pulmonary blood volume, and cardiac function. Methods and Results-A single-center prospective cohort study of patients with chronic obstructive pulmonary disease was conducted. Clinical characteristics and computed tomography metrics, including the PA: A and pulmonary blood vessel volume, were measured. Ventricular functions, volumes, and dimensions were measured by cine cardiac MRI with 3-dimensional analysis. Linear regression examined the relationships between clinical characteristics, computed tomography and cardiac MRI metrics, and 6-minute walk distance. Twenty-four patients were evaluated and those with PA:A>1 had higher right ventricular (RV) end-diastolic and end-systolic volume indices accompanied by lower RV ejection fraction (52 +/- 7% versus 60 +/- 9%; P=0.04). The PA: A correlated inversely with total intraparenchymal pulmonary blood vessel volume and the volume of distal vessels with a cross-sectional area of <5 mm(2). Lower forced expiratory volume, PA:A>1, and hyperinflation correlated with reduced RV ejection fraction. Both PA diameter and reduced RV ejection fraction were independently associated with reduced 6-minute walk distance. Conclusions-The loss of blood volume in distal pulmonary vessels is associated with PA enlargement on computed tomography. Cardiac MRI detects early RV dysfunction and remodeling in nonsevere chronic obstructive pulmonary disease patients with a PA:A>1. Both RV dysfunction and PA enlargement are independently associated with reduced walk distance. C1 [Wells, J. Michael; Gupta, Himanshu; Lloyd, Steven G.; Dell'Italia, Louis J.; Dransfield, Mark T.] Birmingham VA Med Ctr, Birmingham, AL USA. [Wells, J. Michael; Iyer, Anand S.; Bhatt, Surya P.; Gupta, Himanshu; Lloyd, Steven G.; Dell'Italia, Louis J.; Dransfield, Mark T.] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA. [Wells, J. Michael; Bhatt, Surya P.; Dransfield, Mark T.] Univ Alabama Birmingham, Div Pulm Allergy & Crit Care, Lung Hlth Ctr, Birmingham, AL USA. [Gupta, Himanshu; Lloyd, Steven G.; Dell'Italia, Louis J.] Univ Alabama Birmingham, Div Cardiovasc Dis, Birmingham, AL 35294 USA. [Nath, Hrudaya] Univ Alabama Birmingham, Dept Radiol, Birmingham, AL USA. [Rahaghi, Farbod N.; Washko, George R.] Brigham & Womens Hosp, Div Pulm & Crit Care Med, Boston, MA 02115 USA. [Estepar, Raul San Jose] Harvard Univ, Sch Med, Dept Radiol, Brigham & Womens Hosp, Boston, MA 02115 USA. [Denney, Thomas S.] Auburn Univ, Dept Elect & Comp Engn, Birmingham, AL USA. RP Wells, JM (reprint author), 1900 Univ Blvd,THT 422, Birmingham, AL 35294 USA. EM jmwells@uab.edu FU Walter B. Frommeyer Jr Fellowship in Investigational Medicine, University of Alabama at Birmingham; National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) [K08HL1123940]; American Heart Association [13CRP16750005]; NIH NHLBI [R01-HL104018, K25 HL104085-04, 1R01HL116931-02, R01HL116473-02, R01HL116473]; NHLBI [U01HL089897, U01HL089856] FX Walter B. Frommeyer Jr Fellowship in Investigational Medicine, University of Alabama at Birmingham and National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) K08HL1123940 (to Dr Wells); American Heart Association 13CRP16750005 (to Dr Bhatt); NIH NHLBI R01-HL104018 (to Dr Gupta); K25 HL104085-04 and 1R01HL116931-02 and R01HL116473-02 (to Dr Estepar); R01HL116473 (to Dr Washko); The COPDGene project is supported by grants from the NHLBI (U01HL089897 and U01HL089856) NR 44 TC 5 Z9 5 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1941-9651 EI 1942-0080 J9 CIRC-CARDIOVASC IMAG JI Circ.-Cardiovasc. Imaging PD APR PY 2015 VL 8 IS 4 AR e002546 DI 10.1161/CIRCIMAGING.114.002546 PG 12 WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical Imaging SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine & Medical Imaging GA CG5CX UT WOS:000353309800004 ER PT J AU McNeil, JK AF McNeil, Juli K. TI Letter to the Editor for the Special Issue on Military Social Work SO JOURNAL OF SOCIAL WORK EDUCATION LA English DT Letter C1 US Dept Vet Affairs, Vet Integrated Serv Network VISN 17, Washington, DC 20420 USA. RP McNeil, JK (reprint author), US Dept Vet Affairs, Vet Integrated Serv Network VISN 17, Washington, DC 20420 USA. NR 8 TC 0 Z9 0 U1 2 U2 2 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1043-7797 EI 2163-5811 J9 J SOC WORK EDUC JI J. Soc. Work Educ. PD APR 1 PY 2015 VL 51 SU 1 SI SI BP S145 EP S148 DI 10.1080/10437797.2015.1001297 PG 4 WC Education & Educational Research; Social Work SC Education & Educational Research; Social Work GA CG7RA UT WOS:000353500900011 ER PT J AU Ersek, M Thorpe, J Kim, H Thomasson, A Smith, D AF Ersek, Mary Thorpe, Joshua Kim, Hyejin Thomasson, Arwin Smith, Dawn TI Exploring End-of-Life Care in Veterans Affairs Community Living Centers SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Article DE nursing homes; palliative care; end-of-life care; veterans; quality of care ID NURSING-HOME RESIDENTS; FAMILY ASSESSMENT; PALLIATIVE CARE; QUALITY MEASURE; NATIONWIDE; HOSPICE; PERCEPTIONS; TRANSITIONS; PLACE AB ObjectivesTo compare quality of end-of-life (EOL) care indicators and family evaluation of care in community living centers (CLCs) with that of EOL care in acute, intensive, and hospice and palliative care units. DesignRetrospective chart review and survey with next of kin of recently deceased inpatients. SettingInpatient Veterans Affairs (VA) Medical Centers (N=145), including 132 CLCs, across the United States. ParticipantsThe chart review included all individuals who died in VA inpatient units (n=57,397). Family survey results included data for 33,497 veterans. MeasurementsIndicators of optimal EOL care: palliative consultation in the last 90days of life, contact with a chaplain, family contact with a chaplain, and emotional support given to family after death. The main outcome was a single Bereaved Family Survey item in which respondents provided a global evaluation of quality of EOL care (excellent to very good, good, fair to poor). ResultsFamily evaluations of overall EOL care and quality of EOL care indicators for veterans who died in CLCs were better than those of veterans dying in acute or intensive care units but worse than those dying in hospice or palliative care units. ConclusionCare in CLCs can be enhanced through the integration of palliative care practices. Future research should identify critical elements of enhancing EOL care in nursing homes. C1 [Ersek, Mary; Thorpe, Joshua; Thomasson, Arwin; Smith, Dawn] Vet Affairs Med Ctr, Performance Reporting & Outcomes Measurement Impr, Philadelphia, PA USA. [Ersek, Mary; Kim, Hyejin; Smith, Dawn] Univ Penn, Sch Nursing, Philadelphia, PA 19104 USA. [Thorpe, Joshua] Vet Affairs Med Ctr, Ctr Hlth Equ Res & Promot, Pittsburgh, PA USA. [Thorpe, Joshua] Univ Pittsburgh, Sch Pharm, Dept Pharm & Therapeut, Pittsburgh, PA 15261 USA. RP Ersek, M (reprint author), Philadelphia Vet Affairs Med Ctr, 3900 Woodland Ave,Annex Suite 203, Philadelphia, PA 19104 USA. EM mary.ersek@va.gov FU Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development FX This material is based upon work supported by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, which had no role in the design, methods, participant recruitment, data collection, analysis, or preparation of manuscript or in the decision to submit the manuscript for publication. All authors had access to the data and take responsibility for the integrity of the data and the accuracy of the data analysis. The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs or the U.S. government. NR 27 TC 1 Z9 1 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 IS 4 BP 644 EP 650 DI 10.1111/jgs.13348 PG 7 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CG4EB UT WOS:000353234900003 PM 25809839 ER PT J AU Eng, JA Clough-Gorr, K Cabral, HJ Silliman, RA AF Eng, Jessica A. Clough-Gorr, Kerri Cabral, Howard J. Silliman, Rebecca A. TI Predicting 5-and 10-Year Survival in Older Women with Early-Stage Breast Cancer: Self-Rated Health and Walking Ability SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Article DE breast cancer; physical function; self-rated health ID COMPREHENSIVE GERIATRIC ASSESSMENT; SOCIAL SUPPORT SURVEY; PROGNOSTIC-FACTORS; PROSTATE-CANCER; SURVEY SF-36; MORTALITY; FRAILTY; OUTCOMES; ADULTS; MULTICENTER AB ObjectivesTo determine life expectancy for older women with breast cancer. DesignProspective longitudinal study with 10years of follow-up data. SettingHospitals or collaborating tumor registries in four geographic regions (Los Angeles, California; Minnesota; North Carolina; Rhode Island). ParticipantsWomen aged 65 and older at time of breast cancer diagnosis with Stage I to IIIA disease with measures of self-rated health (SRH) and walking ability at baseline (N=615; 17% aged 80, 52% Stage I, 58% with 2 comorbidities). MeasurementsBaseline SRH, baseline self-reported walking ability, all-cause and breast cancer-specific estimated probability of 5- and 10-year survival. ResultsAt the time of breast cancer diagnosis, 39% of women reported poor SRH, and 28% reported limited ability to walk several blocks. The all-cause survival curves appear to separate after approximately 3years, and the difference in survival probability between those with low SRH and limited walking ability and those with high SRH and no walking ability limitation was significant (0.708 vs 0.855 at 5years, P.001; 0.300 vs 0.648 at 10years, P<.001). There were no differences between the groups in breast cancer-specific survival at 5 and 10years (P = .66 at 5years, P=.16 at 10years). ConclusionThe combination of low SRH and limited ability to walk several blocks at diagnosis is an important predictor of worse all-cause survival at 5 and 10years. These self-report measures easily assessed in clinical practice may be an effective strategy to improve treatment decision-making in older adults with cancer. C1 [Eng, Jessica A.] Univ Calif San Francisco, Div Geriatr, San Francisco, CA 94143 USA. [Eng, Jessica A.] San Francisco VA Med Ctr, San Francisco, CA USA. [Clough-Gorr, Kerri] Univ Bern, Inst Social & Prevent Med, Bern, Switzerland. [Cabral, Howard J.] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA. [Silliman, Rebecca A.] Boston Univ, Sch Med, Sect Geriatr, Boston, MA 02118 USA. [Silliman, Rebecca A.] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA USA. RP Eng, JA (reprint author), San Francisco VA Med Ctr, 4150 Clement St,181G, San Francisco, CA 94121 USA. EM jessica.eng@ucsf.edu FU National Cancer Institute [R01 CA106979, R01 CA/AG 70818, R01 CA84506]; John A. Hartford Foundation; Department of Veterans Affairs Quality Scholars Program; Boston University Clinical and Translational Science Institute (CTSI); National Institutes for Health [K05 CA92395] FX Data collection for the initial study was supported by the National Cancer Institute (R01 CA106979, R01 CA/AG 70818, R01 CA84506). Dr. Eng was supported by the John A. Hartford Foundation and the Department of Veterans Affairs Quality Scholars Program. Dr. Cabral was supported by the Boston University Clinical and Translational Science Institute (CTSI). Dr. Silliman was supported by the National Institutes for Health (K05 CA92395). NR 30 TC 4 Z9 4 U1 1 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 IS 4 BP 757 EP 762 DI 10.1111/jgs.13340 PG 6 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CG4EB UT WOS:000353234900019 PM 25900489 ER PT J AU Kramer, BJ Creekmur, B Cote, S Saliba, D AF Kramer, Betty Jo (Josea) Creekmur, Beth Cote, Sarah Saliba, Debra TI Improving Access to Noninstitutional Long-Term Care for American Indian Veterans SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Article DE rural; Department of Veterans Affairs; Indian Health Service ID QUALITY-OF-LIFE; HEALTH-SERVICE; DUAL-USE; MANAGEMENT AB Home-based primary care (HBPC) is an effective model of noninstitutional long-term care developed in the Department of Veterans Affairs (VA) to provide ongoing care to homebound persons. Significant rural populations of American Indians have limited access to services designed for frail older adults. Fourteen Veterans Affairs Medical Centers (VAMCs) initiated efforts to expand access to HBPC in concert with local tribes and Indian Health Service (IHS) facilities. This study characterizes the resulting emerging models of HBPC and co-management. Using an observational design, key respondent telephone interviews (n=37) were conducted with stakeholders representing the 14 VAMCs to describe these HBPC programs, and HBPC models were evaluated in relation to VAMC organizational culture as revealed on the annual VA All Employee Survey. Twelve VAMCs independently developed HBPC expansion programs for American Indian veterans, and six different program models were implemented. Two models were unique to collaborations between VAMCs and tribes; in these collaborations, the tribes retained primary care responsibilities. VAMC used the other four models for delivery of care in remote rural areas to all veteran populations, American Indians and non-Indians alike. Strategies to improve access by reducing geographic barriers occur in all models. Comparing mean VAMC organizational culture ratings, as defined in the Competing Values Framework, revealed significant group differences for one of these six models. Findings from this study illustrate the flexibility of the HBPC program and opportunities for co-management and expansion of healthcare access for American Indians and non-Indians, particularly in rural areas. C1 [Kramer, Betty Jo (Josea); Creekmur, Beth; Cote, Sarah; Saliba, Debra] Vet Affairs Greater Los Angeles Healthcare Syst, Geriatr Res Educ & Clin Ctr, Los Angeles, CA USA. [Kramer, Betty Jo (Josea); Saliba, Debra] Univ Calif Los Angeles, David Geffen Sch Med, Div Geriatr Med, Los Angeles, CA 90095 USA. [Saliba, Debra] Univ Calif Los Angeles, Jewish Home Borun Ctr Gerontol Res, Los Angeles, CA USA. [Saliba, Debra] RAND Corp, Santa Monica, CA USA. RP Kramer, BJ (reprint author), Greater Los Angeles Healthcare Syst GRECC, 16111 Plummer St 11E, Sepulveda, CA 91343 USA. EM josea.kramer@va.gov OI Creekmur, Beth/0000-0001-7802-1125 FU VA Health Services Research [RRP 12-434, IIR 12-063]; VA Office of Rural Health through VA Office of Geriatrics and Extended Care FX Project Support: VA Health Services Research RRP 12-434 and IIR 12-063.; We wish to acknowledge the invaluable assistance of Barry Kraus in background research and facilitating key respondent interviews. We also wish to acknowledge that the funding source for the HBPC expansion projects was the VA Office of Rural Health through a proposal from the VA Office of Geriatrics and Extended Care. We would also like to thank the VHA Organizational Assessment Sub-Committee for reviewing the study proposal and granting access to the AES data. The valuable contribution of the National Center for Organization Development staff for collecting and managing these data is also appreciated. We thank the National Center for Organization Development for working with us to determine the appropriate data subset and preparing the data for our research purposes. NR 30 TC 0 Z9 0 U1 1 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 IS 4 BP 789 EP 796 DI 10.1111/jgs.13344 PG 8 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CG4EB UT WOS:000353234900024 PM 25854124 ER PT J AU Chen, P Dowal, S Schmitt, E Habtemariam, D Hshieh, TT Victor, R Boockvar, KS Inouye, SK AF Chen, Pei Dowal, Sarah Schmitt, Eva Habtemariam, Daniel Hshieh, Tammy T. Victor, Ryan Boockvar, Kenneth S. Inouye, Sharon K. TI Hospital Elder Life Program in the Real World: The Many Uses of the Hospital Elder Life Program Website SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Article DE Hospital Elder Life Program; delirium prevention; dementia; program dissemination; geriatrics education; web-based training ID PREDICTION RULE; DELIRIUM; INTERVENTIONS; CARE; OUTCOMES; SURGERY; MODEL AB The Hospital Elder Life Program (HELP) can prevent delirium, a common condition in older hospitalized adults associated with substantial morbidity, mortality, and healthcare costs. In 2011, HELP transitioned to a web-based dissemination model to provide accessible resources, including implementation materials; information for healthcare professionals, patients, and families; and a searchable reference database. It was hypothesized that, although intended to assist sites to establish HELP, the resources that the HELP website offer might have broader applications. An e-mail was sent to all HELP website registrants from September 10, 2012, to March 15, 2013, requesting participation in an online survey to examine uses of the resources on the website and to evaluate knowledge diffusion related to these resources. Of 102 responding sites, 73 (72%) completed the survey. Thirty-nine (53%) had implemented and maintained an active HELP model. Twenty-six (35%) sites had used the HELP website resources to plan for implementation of the HELP model and 35 (50%) sites to implement and support the program during and after launch. Sites also used the resources for the development of non-HELP delirium prevention programs and guidelines. Forty-five sites (61%) used the website resources for educational purposes, targeting healthcare professionals, patients, families, or volunteers. The results demonstrated that HELP resources were used for implementation of HELP and other delirium prevention programs and were also disseminated broadly in innovative educational efforts across the professional and lay communities. C1 [Chen, Pei; Boockvar, Kenneth S.] Icahn Sch Med Mt Sinai, Brookdale Dept Geriatr & Palliat Med, New York, NY 10029 USA. [Dowal, Sarah; Schmitt, Eva; Habtemariam, Daniel; Victor, Ryan; Inouye, Sharon K.] Hebrew SeniorLife, Inst Aging Res, Boston, MA USA. [Hshieh, Tammy T.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Aging, Boston, MA 02115 USA. [Boockvar, Kenneth S.] James J Peters VA Med Ctr, Geriatr Res Educ & Clin Ctr, Bronx, NY USA. [Inouye, Sharon K.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Div Gerontol, Boston, MA 02215 USA. RP Chen, P (reprint author), Icahn Sch Med Mt Sinai, Brookdale Dept Geriatr & Palliat Med, One Gustave L Levy Pl,Box 1070, New York, NY 10029 USA. EM pei.chen@mssm.edu OI Boockvar, Kenneth/0000-0003-1165-5558 FU National Institute on Aging [K07AG041835]; Retirement Research Foundation [2013-87]; National Institutes of Health [AG000158]; Fan Fox and Leslie Samuels Foundation; Greenwall Foundation; Mount Sinai Older Americans Independence Center; Milton and Shirley F. Levy Family Chair FX This work was supported in part by Grants K07AG041835 (SKI) from the National Institute on Aging and 2013-87 (SKI) from the Retirement Research Foundation. Dr. Hshieh is supported by the T32 Training Grant AG000158 from the National Institutes of Health. Dr. Boockvar is supported by the Fan Fox and Leslie Samuels Foundation, Greenwall Foundation, and Mount Sinai Older Americans Independence Center. Dr. Inouye is supported by the Milton and Shirley F. Levy Family Chair. NR 30 TC 0 Z9 0 U1 2 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 IS 4 BP 797 EP 803 DI 10.1111/jgs.13343 PG 7 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CG4EB UT WOS:000353234900025 PM 25877747 ER PT J AU Fang, MA Heiney, C Yentes, JM Harada, ND Masih, S Perell-Gerson, KL AF Fang, Meika A. Heiney, Constance Yentes, Jennifer M. Harada, Nancy D. Masih, Sulabha Perell-Gerson, Karen L. TI Effects of Contralateral Versus Ipsilateral Cane Use on Gait in People with Knee Osteoarthritis SO PM&R LA English DT Article ID RADIOGRAPHIC DISEASE PROGRESSION; EULAR RECOMMENDATIONS; HIP; PAIN; CLASSIFICATION; MANAGEMENT; MOMENTS; FORCE; USAGE; RISK AB Objective: To compare the immediate effects of contralateral versus ipsilateral cane use on spatiotemporal gait parameters and peak vertical ground force in overweight or obese adults with symptomatic knee osteoarthritis (OA). Design: Prospective observational study. Setting: An academic tertiary Veterans Affairs Healthcare Center. Participants: Thirty-eight overweight or obese subjects with symptomatic knee OA who had not used a cane for the past 30 days. Methods: Spatiotemporal gait data were obtained with an optical motion capture system while subjects walked without a cane, with a cane contralateral to the more painful lower limb, or with a cane ipsilateral to the more painful lower limb at self-selected speeds. An in-shoe dynamic pressure distribution system was used to measure the vertical ground reaction force. Main Outcome Measurements: Spatiotemporal measures of gait and peak vertical ground reaction force on both lower limbs were recorded for each walking condition: no cane, contralateral cane, and ipsilateral cane. Results: Walking with a cane either contralateral or ipsilateral to the more symptomatic limb led to significant reductions in gait velocity (14%-16%), cadence (12%-14%), and peak vertical ground reaction force (normalized for body weight; 11%-12%) on the more painful lower limb compared with walking unaided (P < .05). There were no significant differences in the peak vertical ground reaction force on either lower limbs when comparing walking with a cane contralateral to the more painful limb or walking with a cane ipsilateral to the more painful limb. Subjects also experienced a significant decrease in gait velocity with contralateral or ipsilateral cane use compared with walking without a cane; the lower walking speed was due to a decrease in cadence. Conclusions: These results support the prescription of a single-point cane to offload a lower limb with painful knee OA by holding the cane either ipsilateral or contralateral to the more painful lower limb. C1 [Fang, Meika A.; Heiney, Constance; Harada, Nancy D.; Masih, Sulabha; Perell-Gerson, Karen L.] Vet Affairs Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. [Fang, Meika A.; Harada, Nancy D.; Masih, Sulabha] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA. [Yentes, Jennifer M.] Univ Nebraska, Nebraska Biomech Core Facil, Omaha, NE 68182 USA. [Perell-Gerson, Karen L.] Georgia Gwinnett Coll, Sch Sci & Technol, Lawrenceville, GA USA. RP Fang, MA (reprint author), VA West Los Angeles Healthcare Ctr, Rheumatol Sect, 111J,11301 Wilshire Blvd, Los Angeles, CA 90073 USA. EM meika.fang@va.gov OI Yentes, Jennifer/0000-0001-6550-7759 FU Veterans Affairs Office of Research and Development, Rehabilitation Research and Development Service [F3873R] FX This work was supported by the Veterans Affairs Office of Research and Development, Rehabilitation Research and Development Service (grant F3873R; ClinicalTrials.gov identifier No. NCT00223795). NR 36 TC 0 Z9 0 U1 1 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1934-1482 EI 1934-1563 J9 PM&R JI PM&R PD APR PY 2015 VL 7 IS 4 BP 400 EP 406 DI 10.1016/j.pmrj.2014.09.018 PG 7 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA CG2QZ UT WOS:000353120900007 PM 25305371 ER PT J AU Marcus, EA Wozniak, LJ Venick, RS Ponthieux, SM Cheng, EY Farmer, DG AF Marcus, E. A. Wozniak, L. J. Venick, R. S. Ponthieux, S. M. Cheng, E. Y. Farmer, D. G. TI Successful Term Pregnancy in an Intestine-Pancreas Transplant Recipient With Chronic Graft Dysfunction and Parenteral Nutrition Dependence: A Case Report SO TRANSPLANTATION PROCEEDINGS LA English DT Article ID LIVER-TRANSPLANTATION; TACROLIMUS; PATIENT; REPRODUCTION; INFANTS AB Pregnancy after solid organ transplantation is becoming more common, with the largest recorded numbers in renal and liver transplant recipients. Intestinal transplantation is relatively new compared to other solid organs, and reports of successful pregnancy are far less frequent. All pregnancies reported to date in intestinal transplant recipients have been in women with stable graft function. The case reported here involves the first reported successful term pregnancy in an intestine-pancreas transplant recipient with chronic graft dysfunction and dependence on both transplant immunosuppression and parenteral nutrition (PN) at the time of conception. Pregnancy was unplanned and unexpected in the setting of chronic illness and menstrual irregularities, discovered incidentally on abdominal ultrasound at approximately 18 weeks' gestation. Rapamune was held, tacrolimus continued, and PN adjusted to maintain consistent weight gain. A healthy female infant was delivered vaginally at term. Medical complications during pregnancy included anemia and need for tunneled catheter replacements. Ascites and edema were improved from baseline, with recurrence of large volume ascites shortly after delivery. Successful pregnancy is possible in the setting of transplant immunosuppression, chronic intestinal graft dysfunction, and long-term PN requirement, but close monitoring is required to ensure the health of mother and child. C1 [Marcus, E. A.; Wozniak, L. J.; Venick, R. S.] Univ Calif Los Angeles, DGSOM, Dept Pediat, Los Angeles, CA 90095 USA. [Marcus, E. A.] VA Greater Los Angeles Hlth Care Syst, Los Angeles, CA USA. [Venick, R. S.; Ponthieux, S. M.; Cheng, E. Y.; Farmer, D. G.] Univ Calif Los Angeles, DGSOM, Dept Surg, Dumont UCLA Transplant Ctr, Los Angeles, CA 90095 USA. RP Marcus, EA (reprint author), Univ Calif Los Angeles, DGSOM, Div Pediat Gastroenterol Hepatol & Nutr, Dept Pediat, 10833 LeConte Ave,12-383 MDCC, Los Angeles, CA 90095 USA. EM emarcus@mednet.ucla.edu FU NIDDK NIH HHS [K08 DK100661] NR 31 TC 2 Z9 2 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0041-1345 EI 1873-2623 J9 TRANSPL P JI Transplant. Proc. PD APR PY 2015 VL 47 IS 3 BP 863 EP 867 DI 10.1016/j.transproceed.2015.01.009 PG 5 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA CG6PT UT WOS:000353424900068 PM 25724255 ER PT J AU Kanzaria, HK Hoffman, JR Probst, MA Caloyeras, JP Berry, SH Brook, RH AF Kanzaria, Hemal K. Hoffman, Jerome R. Probst, Marc A. Caloyeras, John P. Berry, Sandra H. Brook, Robert H. TI Emergency Physician Perceptions of Medically Unnecessary Advanced Diagnostic Imaging SO ACADEMIC EMERGENCY MEDICINE LA English DT Article ID EVIDENCE-BASED MEDICINE; MINOR HEAD TRAUMA; US HEALTH-CARE; DECISION-MAKING; DEFENSIVE MEDICINE; PERFORMANCE-MEASURES; DEPARTMENT PATIENTS; NATIONAL TRENDS; COST; MALPRACTICE AB ObjectivesThe objective was to determine emergency physician (EP) perceptions regarding 1) the extent to which they order medically unnecessary advanced diagnostic imaging, 2) factors that contribute to this behavior, and 3) proposed solutions for curbing this practice. MethodsAs part of a larger study to engage physicians in the delivery of high-value health care, two multispecialty focus groups were conducted to explore the topic of decision-making around resource utilization, after which qualitative analysis was used to generate survey questions. The survey was extensively pilot-tested and refined for emergency medicine (EM) to focus on advanced diagnostic imaging (i.e., computed tomography [CT] or magnetic resonance imaging [MRI]). The survey was then administered to a national, purposive sample of EPs and EM trainees. Simple descriptive statistics to summarize physician responses are presented. ResultsIn this study, 478 EPs were approached, of whom 435 (91%) completed the survey; 68% of respondents were board-certified, and roughly half worked in academic emergency departments (EDs). Over 85% of respondents believe too many diagnostic tests are ordered in their own EDs, and 97% said at least some (mean= 22%) of the advanced imaging studies they personally order are medically unnecessary. The main perceived contributors were fear of missing a low-probability diagnosis and fear of litigation. Solutions most commonly felt to be extremely or very helpful for reducing unnecessary imaging included malpractice reform (79%), increased patient involvement through education (70%) and shared decision-making (56%), feedback to physicians on test-ordering metrics (55%), and improved education of physicians on diagnostic testing (50%). ConclusionsOverordering of advanced imaging may be a systemic problem, as many EPs believe a substantial proportion of such studies, including some they personally order, are medically unnecessary. Respondents cited multiple complex factors with several potential high-yield solutions that must be addressed simultaneously to curb overimaging. C1 [Kanzaria, Hemal K.] Robert Wood Johnson Fdn Clin Scholars Program, Los Angeles, CA USA. [Kanzaria, Hemal K.] US Dept Vet Affairs, Los Angeles, CA USA. [Kanzaria, Hemal K.] Univ Calif Los Angeles, Los Angeles, CA USA. [Hoffman, Jerome R.] Univ Calif Los Angeles, Ctr Emergency Med, Los Angeles, CA 90024 USA. [Probst, Marc A.] Mt Sinai Med Ctr, Dept Emergency Med, New York, NY 10029 USA. [Caloyeras, John P.; Berry, Sandra H.; Brook, Robert H.] RAND Corp, Santa Monica, CA USA. [Caloyeras, John P.] Pardee RAND Grad Sch, Santa Monica, CA USA. [Brook, Robert H.] Univ Calif Los Angeles, David Geffen Sch Med, Jonathan & Karin Fielding Sch Publ Hlth, Los Angeles, CA 90095 USA. RP Kanzaria, HK (reprint author), Robert Wood Johnson Fdn Clin Scholars Program, Los Angeles, CA USA. EM hkanzaria@mednet.ucla.edu FU VA Office of Academic Affiliations through the VA/Robert Wood Johnson Foundation Clinical Scholars program; National Heart, Lung, and Blood Institute of the National Institutes of Health [5K12 HL109005] FX This work was supported by the VA Office of Academic Affiliations through the VA/Robert Wood Johnson Foundation Clinical Scholars program (Dr. Kanzaria) and the National Heart, Lung, and Blood Institute of the National Institutes of Health under Award Number 5K12 HL109005 (Dr. Probst). The funding agencies had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript. NR 70 TC 27 Z9 27 U1 2 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1069-6563 EI 1553-2712 J9 ACAD EMERG MED JI Acad. Emerg. Med. PD APR PY 2015 VL 22 IS 4 SI SI BP 390 EP 398 DI 10.1111/acem.12625 PG 9 WC Emergency Medicine SC Emergency Medicine GA CF5BN UT WOS:000352569900002 PM 25807868 ER PT J AU Kanzaria, HK Brook, RH Probst, MA Harris, D Berry, SH Hoffman, JR AF Kanzaria, Hemal K. Brook, Robert H. Probst, Marc A. Harris, Dustin Berry, Sandra H. Hoffman, Jerome R. TI Emergency Physician Perceptions of Shared Decision-making SO ACADEMIC EMERGENCY MEDICINE LA English DT Article ID PRIMARY-CARE; WORKFORCE; MEDICINE AB ObjectivesDespite the potential benefits of shared decision-making (SDM), its integration into emergency care is challenging. Emergency physician (EP) perceptions about the frequency with which they use SDM, its potential to reduce medically unnecessary diagnostic testing, and the barriers to employing SDM in the emergency department (ED) were investigated. MethodsAs part of a larger project examining beliefs on overtesting, questions were posed to EPs about SDM. Qualitative analysis of two multispecialty focus groups was done exploring decision-making around resource use to generate survey items. The survey was then pilot-tested and revised to focus on advanced diagnostic imaging and SDM. The final survey was administered to EPs recruited at four emergency medicine (EM) conferences and 15 ED group meetings. This report addresses responses regarding SDM. ResultsA purposive sample of 478 EPs from 29 states were approached, of whom 435 (91%) completed the survey. EPs estimated that, on average, multiple reasonable management options exist in over 50% of their patients and reported employing SDM with 58% of such patients. Respondents perceived SDM as a promising solution to reduce overtesting. However, despite existing research to the contrary, respondents also commonly cited beliefs that 1) many patients prefer that the physician decides, 2) when offered a choice, many patients opt for more aggressive care than they need, and 3) it is too complicated for patients to know how to choose. ConclusionsMost surveyed EPs believe SDM is a potential high-yield solution to overtesting, but many perceive patient-related barriers to its successful implementation. C1 [Kanzaria, Hemal K.] Univ Calif Los Angeles, Robert Wood Johnson Fdn Clin Scholars Program, Los Angeles, CA 90024 USA. [Kanzaria, Hemal K.] Univ Calif Los Angeles, US Dept Vet Affairs, Los Angeles, CA USA. [Brook, Robert H.; Harris, Dustin] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA. [Brook, Robert H.] Univ Calif Los Angeles, Jonathan & Karin Fielding Sch Publ Hlth, Los Angeles, CA USA. [Hoffman, Jerome R.] Univ Calif Los Angeles, Ctr Emergency Med, Los Angeles, CA 90024 USA. [Brook, Robert H.; Berry, Sandra H.] RAND Corp, Santa Monica, CA USA. [Probst, Marc A.] Mt Sinai Med Ctr, Dept Emergency Med, New York, NY 10029 USA. RP Kanzaria, HK (reprint author), Univ Calif Los Angeles, Robert Wood Johnson Fdn Clin Scholars Program, Los Angeles, CA 90024 USA. EM hkanzaria@mednet.ucla.edu FU VA Office of Academic Affiliations through the VA/Robert Wood Johnson Foundation Clinical Scholars program; National Heart, Lung and Blood Institute of the National Institutes of Health [5K12 HL109005] FX This work was supported by the VA Office of Academic Affiliations through the VA/Robert Wood Johnson Foundation Clinical Scholars program (Dr. Kanzaria) and the National Heart, Lung and Blood Institute of the National Institutes of Health under Award Number 5K12 HL109005 (Dr. Probst). The funding agencies had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript. NR 7 TC 23 Z9 23 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1069-6563 EI 1553-2712 J9 ACAD EMERG MED JI Acad. Emerg. Med. PD APR PY 2015 VL 22 IS 4 SI SI BP 399 EP 405 DI 10.1111/acem.12627 PG 7 WC Emergency Medicine SC Emergency Medicine GA CF5BN UT WOS:000352569900003 PM 25807995 ER PT J AU Scales, CD Lin, L Saigal, CS Bennett, CJ Ponce, NA Mangione, CM Litwin, MS AF Scales, Charles D., Jr. Lin, Li Saigal, Christopher S. Bennett, Carol J. Ponce, Ninez A. Mangione, Carol M. Litwin, Mark S. CA NIDDK Urologic Dis Amer Project TI Emergency Department Revisits for Patients with Kidney Stones in California SO ACADEMIC EMERGENCY MEDICINE LA English DT Article ID UNITED-STATES; MANAGEMENT; DISEASE; UROLITHIASIS; PREVALENCE; PATTERNS; VISITS; CARE AB ObjectivesKidney stones affect nearly one in 11 persons in the United States, and among those experiencing symptoms, emergency care is common. In this population, little is known about the incidence of and factors associated with repeat emergency department (ED) visits. The objective was to identify associations between potentially mutable factors and the risk of an ED revisit for patients with kidney stones in a large, all-payer cohort. MethodsThis was a retrospective cohort study of all patients in California initially treated and released from EDs for kidney stones between February 2008 and November 2009. A multivariable regression model was created to identify associations between patient-level characteristics, area health care resources, processes of care, and the risk of repeat ED visits. The primary outcome was a second ED visit within 30days of the initial discharge from emergent care. ResultsAmong 128,564 patients discharged from emergent care, 13,684 (11%) had at least one additional emergent visit for treatment of their kidney stone. In these patients, nearly one in three required hospitalization or an urgent temporizing procedure at the second visit. On multivariable analysis, the risk of an ED revisit was associated with insurance status (e.g., Medicaid vs. private insurance; odds ratio [OR]= 1.52, 95% confidence interval [CI]=1.43 to 1.61; p<0.001). Greater access to urologic care was associated with lower odds of an ED revisit (highest quartile OR= 0.88, 95% CI=0.80 to 0.97; p<0.01 vs. lowest quartile). In exploratory models, performance of a complete blood count was associated with a decreased odds of revisit (OR=0.86, 95% CI=0.75 to 0.97; p=0.02). ConclusionsRepeat high-acuity care affects one in nine patients discharged from initial emergent evaluations for kidney stones. Access to urologic care and processes of care are associated with lower risk of repeat emergent encounters. Efforts are indicated to identify preventable causes of ED revisits for kidney stone patients and design interventions to reduce the risk of high-cost, high-acuity, repeat care. C1 [Scales, Charles D., Jr.; Lin, Li] Duke Univ, Sch Med, Duke Clin Res Inst, Durham, NC 27708 USA. [Scales, Charles D., Jr.] Duke Univ, Sch Med, Div Urol Surg, Durham, NC USA. [Scales, Charles D., Jr.; Mangione, Carol M.] Univ Calif Los Angeles, David Geffen Sch Med, Robert Wood Johnson Fdn, VA Clin Scholars Program, Los Angeles, CA 90095 USA. [Saigal, Christopher S.; Bennett, Carol J.; Litwin, Mark S.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Urol, Los Angeles, CA 90095 USA. [Mangione, Carol M.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA. [Bennett, Carol J.] Greater Los Angeles Vet Hlth Syst, Los Angeles, CA USA. [Saigal, Christopher S.; Litwin, Mark S.] RAND Corp, Santa Monica, CA USA. [Ponce, Ninez A.; Mangione, Carol M.; Litwin, Mark S.] Univ Calif Los Angeles, Dept Hlth Policy & Management, Fielding Sch Publ Hlth, Los Angeles, CA USA. RP Scales, CD (reprint author), Duke Univ, Sch Med, Duke Clin Res Inst, Durham, NC 27708 USA. EM chuck.scales@duke.edu OI Ponce, Ninez/0000-0001-5151-6718 FU Robert Wood Johnson Foundation; VA Office of Academic Affiliations through the VA/Robert Wood Johnson Clinical Scholars Program; UCLA Robert Wood Johnson Clinical Scholars Program; U.S. Department of Veterans Affairs [67799]; University of California at Los Angeles (UCLA); Resource Centers for Minority Aging Research Center for Health Improvement of Minority Elderly under National Institutes of Health (NIH)/NIA [P30-AG021684]; NIH/National Center for Advancing Translational Sciences UCLA Clinical and Translational Science Institute Grant [UL1TR000124]; Barbara A. Levey and Gerald S. Levey Endowed Chair in Medicine; National Institute of Diabetes and Digestive and Kidney Diseases [HHSN276201200016C]; National Library of Medicine FX Dr. Scales was supported by the Robert Wood Johnson Foundation and the VA Office of Academic Affiliations through the VA/Robert Wood Johnson Clinical Scholars Program.; Dr. Mangione received support from the UCLA Robert Wood Johnson Clinical Scholars Program and the U.S. Department of Veterans Affairs (Grant 67799), the University of California at Los Angeles (UCLA), Resource Centers for Minority Aging Research Center for Health Improvement of Minority Elderly under National Institutes of Health (NIH)/NIA Grant P30-AG021684, and from NIH/National Center for Advancing Translational Sciences UCLA Clinical and Translational Science Institute Grant UL1TR000124. Dr. Mangione holds the Barbara A. Levey and Gerald S. Levey Endowed Chair in Medicine, which partially supported her work.; The Urologic Diseases in America Project is supported by Grant HHSN276201200016C from the National Institute of Diabetes and Digestive and Kidney Diseases and the National Library of Medicine. NR 19 TC 8 Z9 8 U1 1 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1069-6563 EI 1553-2712 J9 ACAD EMERG MED JI Acad. Emerg. Med. PD APR PY 2015 VL 22 IS 4 SI SI BP 468 EP 474 DI 10.1111/acem.12632 PG 7 WC Emergency Medicine SC Emergency Medicine GA CF5BN UT WOS:000352569900012 PM 25779695 ER PT J AU Wehner, MR Linos, E Parvataneni, R Stuart, SE Boscardin, WJ Chren, MM AF Wehner, Mackenzie R. Linos, Eleni Parvataneni, Rupa Stuart, Sarah E. Boscardin, W. John Chren, Mary-Margaret TI Timing of Subsequent NewTumors in Patients Who Present With Basal Cell Carcinoma or Cutaneous Squamous Cell Carcinoma SO JAMA DERMATOLOGY LA English DT Article ID NONMELANOMA SKIN-CANCER; RISK-FACTORS; SUNLIGHT EXPOSURE; METAANALYSIS; POPULATION; RECURRENCE AB IMPORTANCE Patients with basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (SCC) (often termed nonmelanoma skin cancer or keratinocyte carcinoma [ KC]) often develop new KCs, but information is limited on the frequency and timing of these subsequent tumors. This information is crucial to guide follow-up care. OBJECTIVE To determine the timing of subsequent new KCs in patients who present with KC. DESIGN, SETTING, AND PARTICIPANTS We enrolled a consecutive cohort of 1426 patients diagnosed as having biopsy-proven KC from January 1, 1999, through December 31, 2000, in a university dermatology practice and its affiliated Department of Veterans Affairs dermatology service. After exclusion of patients with basal cell nevus syndrome and immunocompromise, 1284 patients (90.0%) were followed up prospectively for a mean of 5.7 (range, 0-12.3) years. MAIN OUTCOMES AND MEASURES We assessed the risks for subsequent KCs over time using single-failure and multiple-failure models. We separately assessed outcomes after first lifetime KCs and after nonfirst lifetime KCs. We also performed secondary analyses of the risk for a subsequent BCC after a prior BCC diagnosis and the risk for a subsequent SCC after a prior SCC diagnosis. RESULTS The risk for a subsequent KC was substantially lower after the first lifetime KC diagnosis: 14.5%(95% CI, 11.9%-17.7%) at 1 year, 31.1% (95% CI, 27.3%-35.3%) at 3 years, and 40.7%(95% CI, 36.5%-45.2%) at 5 years, than after a nonfirst KC: 43.9%(95% CI, 42.0%-45.9%) at 1 year, 71.1% (95% CI, 69.1%-73.0%) at 3 years, and 82.0%(95% CI, 80.2%-83.7%) at 5 years. Secondary analyses of the risks for a subsequent BCC after a prior BCC diagnosis and of a subsequent SCC after a prior SCC diagnosis yielded results consistent with the analyses for the pooled KC sample. CONCLUSIONS AND RELEVANCE Although all patients with KC are assumed to be at high risk for subsequent tumors, a subsetmay not develop another KC after their first tumor. Whether these findings are related to biological or behavioral differences or to differences in health care services should be investigated further to inform and improve care. Ongoing routine screening for subsequent KC may not be indicated for all patients with KC. Skin cancer screening can be improved with a better understanding of the course and frequency of subsequent KC diagnoses. C1 [Wehner, Mackenzie R.] Stanford Univ, Sch Med, Stanford, CA 94305 USA. [Boscardin, W. John] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA. [Chren, Mary-Margaret] San Francisco VA Med Ctr, Dermatol Serv, San Francisco, CA USA. RP Chren, MM (reprint author), Univ Calif San Francisco, Dept Dermatol, 2340 Sutter St,Room N412,Box 0808, San Francisco, CA 94143 USA. EM chrenm@derm.ucsf.edu OI Linos, Eleni/0000-0002-5856-6301; , Eleni/0000-0003-2538-0700 FU Doris Duke Charitable Foundation; Dermatology Foundation; National Center for Research Resources of the National Institutes of Health (NIH) [KL2RR024130]; National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH [R01 AR 054983, K24 AR052667] FX Funding/Support: This study was supported in part by grants from the Doris Duke Charitable Foundation (Dr Wehner), by the Dermatology Foundation (Dr Linos), by award KL2RR024130 from the National Center for Research Resources of the National Institutes of Health (NIH) (Dr Linos), and by grants R01 AR 054983 and K24 AR052667 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH (Dr Chren). NR 24 TC 7 Z9 7 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6068 EI 2168-6084 J9 JAMA DERMATOL JI JAMA Dermatol. PD APR PY 2015 VL 151 IS 4 BP 382 EP 388 DI 10.1001/jamadermatol.2014.3307 PG 7 WC Dermatology SC Dermatology GA CF6FI UT WOS:000352652000005 PM 25588079 ER PT J AU Goodkind, M Eickhoff, SB Oathes, DJ Jiang, Y Chang, A Jones-Hagata, LB Ortega, BN Zaiko, YV Roach, EL Korgaonkar, MS Grieve, SM Galatzer-Levy, I Fox, PT Etkin, A AF Goodkind, Madeleine Eickhoff, Simon B. Oathes, Desmond J. Jiang, Ying Chang, Andrew Jones-Hagata, Laura B. Ortega, Brissa N. Zaiko, Yevgeniya V. Roach, Erika L. Korgaonkar, Mayuresh S. Grieve, Stuart M. Galatzer-Levy, Isaac Fox, Peter T. Etkin, Amit TI Identification of a Common Neurobiological Substrate for Mental Illness SO JAMA PSYCHIATRY LA English DT Article ID MAJOR DEPRESSIVE DISORDER; VOXEL-BASED MORPHOMETRY; POSTTRAUMATIC-STRESS-DISORDER; LIKELIHOOD ESTIMATION METAANALYSIS; OBSESSIVE-COMPULSIVE DISORDER; AUTISM SPECTRUM DISORDER; GRAY-MATTER VOLUME; BIPOLAR-DISORDER; FUNCTIONAL CONNECTIVITY; ANTIPSYCHOTIC TREATMENT AB IMPORTANCE Psychiatric diagnoses are currently distinguished based on sets of specific symptoms. However, genetic and clinical analyses find similarities across a wide variety of diagnoses, suggesting that a common neurobiological substrate may exist across mental illness. OBJECTIVE To conduct a meta-analysis of structural neuroimaging studies across multiple psychiatric diagnoses, followed by parallel analyses of 3 large-scale healthy participant data sets to help interpret structural findings in the meta-analysis. DATA SOURCES PubMed was searched to identify voxel-based morphometry studies through July 2012 comparing psychiatric patients to healthy control individuals for the meta-analysis. The 3 parallel healthy participant data sets included resting-state functional magnetic resonance imaging, a database of activation foci across thousands of neuroimaging experiments, and a data set with structural imaging and cognitive task performance data. DATA EXTRACTION AND SYNTHESIS Studies were included in the meta-analysis if they reported voxel-based morphometry differences between patients with an Axis I diagnosis and control individuals in stereotactic coordinates across the whole brain, did not present predominantly in childhood, and had at least 10 studies contributing to that diagnosis (or across closely related diagnoses). The meta-analysis was conducted on peak voxel coordinates using an activation likelihood estimation approach. MAIN OUTCOMES AND MEASURES We tested for areas of common gray matter volume increase or decrease across Axis I diagnoses, as well as areas differing between diagnoses. Follow-up analyses on other healthy participant data sets tested connectivity related to regions arising from the meta-analysis and the relationship of gray matter volume to cognition. RESULTS Based on the voxel-based morphometry meta-analysis of 193 studies comprising 15 892 individuals across 6 diverse diagnostic groups (schizophrenia, bipolar disorder, depression, addiction, obsessive-compulsive disorder, and anxiety), we found that gray matter loss converged across diagnoses in 3 regions: the dorsal anterior cingulate, right insula, and left insula. By contrast, there were few diagnosis-specific effects, distinguishing only schizophrenia and depression from other diagnoses. In the parallel follow-up analyses of the 3 independent healthy participant data sets, we found that the common gray matter loss regions formed a tightly interconnected network during tasks and at resting and that lower gray matter in this network was associated with poor executive functioning. CONCLUSIONS AND REVELANCE We identified a concordance across psychiatric diagnoses in terms of integrity of an anterior insula/dorsal anterior cingulate-based network, which may relate to executive function deficits observed across diagnoses. This concordance provides an organizing model that emphasizes the importance of shared neural substrates across psychopathology, despite likely diverse etiologies, which is currently not an explicit component of psychiatric nosology. C1 [Goodkind, Madeleine; Oathes, Desmond J.; Jiang, Ying; Chang, Andrew; Jones-Hagata, Laura B.; Ortega, Brissa N.; Zaiko, Yevgeniya V.; Roach, Erika L.; Etkin, Amit] Vet Affairs Palo Alto Healthcare Syst, Palo Alto, CA USA. [Goodkind, Madeleine; Oathes, Desmond J.; Jiang, Ying; Chang, Andrew; Jones-Hagata, Laura B.; Ortega, Brissa N.; Zaiko, Yevgeniya V.; Roach, Erika L.; Etkin, Amit] Sierra Pacif Mental Illness Res Educ & Clin Ctr M, Palo Alto, CA USA. [Goodkind, Madeleine; Oathes, Desmond J.; Jiang, Ying; Chang, Andrew; Jones-Hagata, Laura B.; Ortega, Brissa N.; Zaiko, Yevgeniya V.; Roach, Erika L.; Etkin, Amit] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA. [Eickhoff, Simon B.] Res Ctr Julich, INM 1, Julich, Germany. [Eickhoff, Simon B.] Univ Dusseldorf, Inst Clin Neurosci & Med Psychol, Dusseldorf, Germany. [Korgaonkar, Mayuresh S.; Grieve, Stuart M.] Westmead Millennium Inst, Brain Dynam Ctr, Sydney, NSW, Australia. [Korgaonkar, Mayuresh S.; Grieve, Stuart M.] Sydney Med Sc Westmead, Sydney, NSW, Australia. [Korgaonkar, Mayuresh S.; Grieve, Stuart M.] Univ Sydney, Sydney Med Sch, Sydney Translat Imaging Lab, Sydney, NSW 2006, Australia. [Galatzer-Levy, Isaac] NYU, Dept Psychiat, New York, NY 10016 USA. [Fox, Peter T.] Univ Texas Hlth Sci Ctr San Antonio, Res Imaging Inst, San Antonio, TX 78229 USA. [Fox, Peter T.] South Texas Vet Hlth Care Syst, San Antonio, TX USA. [Fox, Peter T.] Univ Hong Kong, Sch Humanities, Hong Kong, Hong Kong, Peoples R China. [Fox, Peter T.] Univ Hong Kong, State Key Lab Brain & Cognit Sci, Hong Kong, Hong Kong, Peoples R China. RP Etkin, A (reprint author), Stanford Univ, Dept Psychiat & Behav Sci, 401 Quarry Rd,MC 5797, Stanford, CA 94305 USA. EM amitetkin@stanford.edu RI Eickhoff, Simon/K-2061-2013 OI Eickhoff, Simon/0000-0001-6363-2759; Oathes, Desmond/0000-0001-7346-2669; Galatzer-Levy, Isaac/0000-0003-1864-064X FU Sierra-Pacific Mental Illness Research, Education and Clinical Center (MIRECC) at the Palo Alto Veterans Affairs; Deutsche Forschungsgemeinschaft [EI 816/4-1, LA 3071/3-1]; National Institute of Mental Health [R01-MH074457]; European Commission (Human Brain Project); National Health and Medical Research Council of Australia project grants scheme [1008080]; Sydney University Medical Foundation; National Institutes of Health/National Institute of Mental Health Award [RO1 MH074457] FX Drs Goodkind and Etkin were funded by the Sierra-Pacific Mental Illness Research, Education and Clinical Center (MIRECC) at the Palo Alto Veterans Affairs. Dr Eickhoff was supported by the Deutsche Forschungsgemeinschaft (EI 816/4-1; SBE and LA 3071/3-1), the National Institute of Mental Health (R01-MH074457), and the European Commission (Human Brain Project). Drs Korgaonkar and Grieve were funded by the National Health and Medical Research Council of Australia project grants scheme (project grant 1008080) and the Sydney University Medical Foundation. Comprehensive access to the BrainMap database was authorized by a collaborative-use license agreement. BrainMap is supported by National Institutes of Health/National Institute of Mental Health Award RO1 MH074457. All VBM studies reported in this article are now coded and accessible through BrainMap. NR 86 TC 97 Z9 98 U1 14 U2 72 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-622X EI 2168-6238 J9 JAMA PSYCHIAT JI JAMA Psychiatry PD APR PY 2015 VL 72 IS 4 BP 305 EP 315 DI 10.1001/jamapsychiatry.2014.2206 PG 11 WC Psychiatry SC Psychiatry GA CF3ZF UT WOS:000352487000002 PM 25651064 ER PT J AU Pietrzak, RH Averill, LA Abdallah, CG Neumeister, A Krystal, JH Levy, I Harpaz-Rotem, I AF Pietrzak, Robert H. Averill, Lynnette A. Abdallah, Chadi G. Neumeister, Alexander Krystal, John H. Levy, Ifat Harpaz-Rotem, Ilan TI Amygdala-Hippocampal Volume and the Phenotypic Heterogeneity of Posttraumatic Stress Disorder: A Cross-Sectional Study SO JAMA PSYCHIATRY LA English DT Letter ID INDIVIDUAL-DIFFERENCES; METAANALYSIS C1 [Pietrzak, Robert H.; Averill, Lynnette A.; Abdallah, Chadi G.; Krystal, John H.; Levy, Ifat; Harpaz-Rotem, Ilan] Natl Ctr Posttraumat Stress Disorder, US Dept Vet Affairs, VA Connecticut Healthcare Syst, Clin Neurosci Div, West Haven, CT 06516 USA. [Pietrzak, Robert H.; Averill, Lynnette A.; Abdallah, Chadi G.; Krystal, John H.; Harpaz-Rotem, Ilan] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA. [Neumeister, Alexander] NYU, Sch Med, Dept Psychiat, New York, NY USA. [Neumeister, Alexander] NYU, Sch Med, Dept Radiol, New York, NY USA. [Levy, Ifat] Yale Univ, Sch Med, Comparat Med Sect, New Haven, CT 06510 USA. RP Pietrzak, RH (reprint author), VA Connecticut Healthcare Syst, Natl Ctr Posttraumat Stress Disorder, US Dept Vet Affairs, 950 Campbell Ave,151E, West Haven, CT 06516 USA. EM robert.pietrzak@yale.edu OI Abdallah, Chadi/0000-0001-5783-6181 FU Clinical Neurosciences Division of the US Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, grant from the National Institutes of Health [K23 MH-101498] FX Preparation of this study was supported in part by the Clinical Neurosciences Division of the US Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, grant K23 MH-101498 from the National Institutes of Health (Dr Abdallah), and a private donation. NR 6 TC 3 Z9 4 U1 1 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-622X EI 2168-6238 J9 JAMA PSYCHIAT JI JAMA Psychiatry PD APR PY 2015 VL 72 IS 4 BP 396 EP 398 DI 10.1001/jamapsychiatry.2014.2470 PG 4 WC Psychiatry SC Psychiatry GA CF3ZF UT WOS:000352487000013 PM 25692480 ER PT J AU King, JT Perkal, MF Rosenthal, RA Gordon, AJ Crystal, S Rodriguez-Barradas, MC Butt, AA Gibert, CL Rimland, D Simberkoff, MS Justice, AC AF King, Joseph T., Jr. Perkal, Melissa F. Rosenthal, Ronnie A. Gordon, Adam J. Crystal, Stephen Rodriguez-Barradas, Maria C. Butt, Adeel A. Gibert, Cynthia L. Rimland, David Simberkoff, Michael S. Justice, Amy C. TI Thirty-Day Postoperative Mortality Among Individuals With HIV Infection Receiving Antiretroviral Therapy and Procedure-Matched, Uninfected Comparators SO JAMA SURGERY LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; POSITIVE PATIENTS; CD4 COUNT; ABDOMINAL OPERATIONS; KIDNEY-TRANSPLANTATION; LIVER-TRANSPLANTATION; SURGICAL-TREATMENT; PROGNOSTIC-FACTOR; CESAREAN-SECTION; LIFE EXPECTANCY AB IMPORTANCE Antiretroviral therapy (ART) has converted human immunodeficiency virus (HIV) infection into a chronic condition, and patients now undergo a variety of surgical procedures, but current surgical outcomes are inadequately characterized. OBJECTIVE To compare 30-day postoperative mortality in patients with HIV infection receiving ART with the rates in uninfected individuals. DESIGN, SETTING, AND PARTICIPANTS Retrospective analysis of nationwide electronic medical record data from the US Veterans Health Administration Healthcare System, October 1, 1996, to September 30, 2010. Common inpatient surgical procedures were grouped using the Healthcare Cost and Utilization Project Clinical Classification System to match HIV-infected and uninfected patients in a 1: 2 ratio. Data on 1641 patients with HIV infection receiving combination ART who were undergoing inpatient surgery were compared with data on 3282 procedure-matched, uninfected comparators. Poisson regression models of 30-day postoperative mortality were adjusted for procedure year, age, Charlson Comorbidity Index score, hemoglobin level, albumin level, HIV infection, CD4 cell count, and HIV-1 RNA level. MAIN OUTCOMES AND MEASURES All-cause 30-day postoperative mortality. RESULTS The most common procedures in both groups were cholecystectomy (10.5%), hip arthroplasty (10.5%), spine surgery (9.8%), herniorrhaphy (7.4%), and coronary artery bypass grafting (7.0%). In patients with HIV infection, CD4 cell distributions were 80.0% with 200/mu L or more, 16.3% with 50/mu L to 199/mu L, and 3.7% with less than 50/mu L; 74.1% of patients with HIV infection had undetectable HIV-1 RNA. Human immunodeficiency virus infection was associated with higher 30-day postoperative mortality compared with the mortality in uninfected patients (3.4%[56 patients]) vs 1.6%[53]); incidence rate ratio [IRR], 2.11; 95% CI, 1.41-3.17; P < .001). CD4 cell count was inversely associated with mortality, but HIV-1 RNA provided no additional information. After adjustment, patients with HIV infection had increased mortality compared with uninfected patients at all CD4 cell count strata (>= 500/mu L: IRR, 1.92; 95% CI, 1.02-3.60; P =.04; 200-499/mu L: IRR, 1.89; 95% CI, 1.20-2.98; P = .01; 50-199/mu L: IRR, 2.66; 95% CI, 1.29-5.47; P = .01; and < 50/mu L: IRR, 6.21; 95% CI, 3.55-10.85; P < .001). Hypoalbuminemia (IRR, 4.35; 95% CI, 2.78-6.81; P < .001) and age in decades (IRR, 1.47; 95% CI, 1.23-1.76; P < .001) were also strongly associated with mortality. CONCLUSIONS AND RELEVANCE Current postoperative mortality rates among individuals with HIV infection who are receiving ART are low and are influenced as much by hypoalbuminemia and age as by CD4 cell status. Human immunodeficiency virus infection and CD4 cell count are only 2 of many factors associated with surgical outcomes that should be incorporated into surgical decision making. C1 [King, Joseph T., Jr.] Vet Affairs VA Connecticut Healthcare Syst, Dept Surg, Sect Neurosurg, West Haven, CT USA. [King, Joseph T., Jr.] Yale Univ, Sch Med, Dept Neurosurg, New Haven, CT USA. [Perkal, Melissa F.; Rosenthal, Ronnie A.] VA Connecticut Healthcare Syst, Sect Gen Surg, Dept Surg, West Haven, CT USA. [Perkal, Melissa F.; Rosenthal, Ronnie A.] Yale Univ, Sch Med, Dept Surg, New Haven, CT 06510 USA. [Gordon, Adam J.; Butt, Adeel A.] Univ Pittsburgh, Sch Med, Dept Med, Pittsburgh, PA 15213 USA. [Gordon, Adam J.; Butt, Adeel A.] VA Pittsburgh Healthcare Syst, Dept Med, Pittsburgh, PA USA. [Gordon, Adam J.; Butt, Adeel A.] Univ Pittsburgh, Sch Med, Dept Med, Div Infect Dis, Pittsburgh, PA 15213 USA. [Crystal, Stephen] Rutgers State Univ, Ctr Hlth Serv Res Pharmacotherapy Chron Dis Manag, New Brunswick, NJ 08903 USA. [Rodriguez-Barradas, Maria C.] Michael E DeBakey VA Med Ctr, Infect Dis Sect, Dept Med, Houston, TX USA. [Rodriguez-Barradas, Maria C.] Baylor Coll Med, Dept Med, Houston, TX 77030 USA. [Gibert, Cynthia L.] VA Med Ctr, Med Serv, Infect Dis Sect, Washington, DC USA. [Gibert, Cynthia L.] George Washington Univ, Sch Med & Hlth Sci, Dept Med, Washington, DC 20052 USA. [Rimland, David] Atlanta VA Med Ctr, Dept Med, Div Infect Dis, Atlanta, GA USA. [Rimland, David] Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA USA. [Simberkoff, Michael S.] VA New York Harbor Healthcare Syst, Dept Med, Infect Dis Sect, New York, NY USA. [Simberkoff, Michael S.] NYU, Sch Med, Dept Med, Infect Dis Sect, New York, NY USA. [Justice, Amy C.] VA Connecticut Healthcare Syst, Dept Med, Gen Internal Med Sect, West Haven, CT USA. [Justice, Amy C.] Yale Univ, Sch Med, Dept Med, Gen Internal Med Sect, New Haven, CT 06510 USA. RP King, JT (reprint author), Vet Affairs Connecticut Healthcare Syst, Dept Surg 113, Sect Neurosurg, 950 Campbell Ave, West Haven, CT 06516 USA. EM joseph.kingjr@va.gov OI Butt, Adeel/0000-0002-1118-1826; Justice, Amy/0000-0003-0139-5502 FU National Institutes of Health: National Institute on Alcohol Abuse and Alcoholism [U10-AA13566]; National Institutes of Health: National Institute on Aging [R01-AG029154]; National Institutes of Health: National Heart, Lung, and Blood Institute [R01-HL095136, R01-HL090342, RCI-HL100347]; National Institutes of Health: National Institute of Allergy and Infectious Disease [U01-A1069918]; National Institutes of Health: National Institute of Mental Health [P30-MH062294]; National Institutes of Health: Agency for Healthcare Research and Quality [U19-HS-021112]; Veterans Health Administration Office of Research and Development [VA REA 8-266]; Office of Academic Affiliations (Medical Informatics Fellowship) FX This work was supported by grants from the National Institutes of Health: National Institute on Alcohol Abuse and Alcoholism (U10-AA13566), National Institute on Aging (R01-AG029154), National Heart, Lung, and Blood Institute (R01-HL095136; R01-HL090342; RCI-HL100347), National Institute of Allergy and Infectious Disease (U01-A1069918), National Institute of Mental Health (P30-MH062294), Agency for Healthcare Research and Quality (U19-HS-021112), and the Veterans Health Administration Office of Research and Development (VA REA 8-266) and Office of Academic Affiliations (Medical Informatics Fellowship). NR 76 TC 3 Z9 3 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6254 EI 2168-6262 J9 JAMA SURG JI JAMA Surg. PD APR PY 2015 VL 150 IS 4 BP 343 EP 351 DI 10.1001/jamasurg.2014.2257 PG 9 WC Surgery SC Surgery GA CG0EB UT WOS:000352938300011 PM 25714794 ER PT J AU Stevenson, K Collins, E Ebert, J Johnson, D Schiffman, J Blair, T AF Stevenson, K. Collins, E. Ebert, J. Johnson, D. Schiffman, J. Blair, T. TI Establishment of a controlled substance advisory review consult process for patients on chronic opioid therapy SO JOURNAL OF PAIN LA English DT Meeting Abstract C1 [Stevenson, K.; Collins, E.; Ebert, J.; Johnson, D.; Schiffman, J.; Blair, T.] William S Middleton Mem Vet Adm Med Ctr, Madison, WI USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1526-5900 J9 J PAIN JI J. Pain PD APR PY 2015 VL 16 IS 4 SU 1 MA 245 BP S37 EP S37 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA CF7PK UT WOS:000352748600147 ER PT J AU Ayala, D Garcia, J Sanchez-Reilly, S AF Ayala, D. Garcia, J. Sanchez-Reilly, S. TI Myths, Beliefs and Their Effect on Pain Control on the Elderly SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS) CY MAY 10-17, 2015 CL National Harbor, MD SP Amer Geriatr Soc C1 [Ayala, D.; Garcia, J.; Sanchez-Reilly, S.] UTHSCSA, San Antonio, TX USA. [Ayala, D.] Univ Texas Houston, Sch Publ Hlth, Houston, TX USA. [Garcia, J.; Sanchez-Reilly, S.] South Texas Vet Hlth Care Syst, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 SU 1 SI SI MA B171 BP S152 EP S152 PG 1 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CF5EL UT WOS:000352578900424 ER PT J AU Boockvar, KS Guerrero, V Torres, J Beckford, K Smyth, C Wen, L Teresi, J Inouye, S AF Boockvar, K. S. Guerrero, V. Torres, J. Beckford, K. Smyth, C. Wen, L. Teresi, J. Inouye, S. TI Characteristics of patients receiving a multicomponent delirium-prevention intervention in the nursing home setting SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS) CY MAY 10-17, 2015 CL National Harbor, MD SP Amer Geriatr Soc C1 [Boockvar, K. S.] James J Peters VA Med Ctr, Bronx, NY USA. [Boockvar, K. S.; Guerrero, V.; Torres, J.; Beckford, K.] Jewish Home Lifecare, New York, NY USA. [Smyth, C.; Wen, L.] Optum CarePlus, Eden Prairie, MN USA. [Teresi, J.] Hebrew Home, Bronx, NY USA. [Teresi, J.] Columbia Univ, New York, NY USA. [Inouye, S.] Hebrew SeniorLife, Boston, MA USA. [Inouye, S.] Harvard Univ, Sch Med, Boston, MA USA. NR 0 TC 0 Z9 0 U1 4 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 SU 1 SI SI MA B79 BP S119 EP S119 PG 1 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CF5EL UT WOS:000352578900332 ER PT J AU Branch-Elliman, W Snyderman, D Wilson, B Carter, R Heath, B Mody, L Moehring, R Crnich, C Schmader, K Jump, R AF Branch-Elliman, W. Snyderman, D. Wilson, B. Carter, R. Heath, B. Mody, L. Moehring, R. Crnich, C. Schmader, K. Jump, R. TI Preliminary Outcomes from an Educational Intervention to Promote Antimicrobial Stewardship and Improve the Care of Older Adults with Infections SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS) CY MAY 10-17, 2015 CL National Harbor, MD SP Amer Geriatr Soc C1 [Branch-Elliman, W.] Vet Affairs Eastern Colorado Hlth Care Syst, Denver, CO USA. [Branch-Elliman, W.] Univ Colorado, Sch Med, Denver, CO USA. [Snyderman, D.] Thomas Jefferson Univ, Philadelphia, PA 19107 USA. [Wilson, B.; Carter, R.; Heath, B.; Jump, R.] Louis Stokes Cleveland VAMC, Cleveland, OH USA. [Carter, R.; Jump, R.] Case Western Reserve Univ, Cleveland, OH 44106 USA. [Mody, L.] Univ Michigan, Ann Arbor, MI 48109 USA. [Mody, L.] VA Ann Arbor Healthcare Syst, Ann Arbor, MI USA. [Moehring, R.; Schmader, K.] Duke Univ, Durham, NC USA. [Moehring, R.; Schmader, K.] Durham VAMC, Durham, NC USA. [Crnich, C.] Univ Wisconsin, Madison, WI USA. [Crnich, C.] William S Middleton Mem Vet Adm Med Ctr, Madison, WI USA. NR 0 TC 0 Z9 0 U1 1 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 SU 1 SI SI MA A106 BP S54 EP S54 PG 1 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CF5EL UT WOS:000352578900152 ER PT J AU Campbell, A Coley, K Thorpe, C Corbo, J McGivney, M Klatt, P Zaharoff, J Cox-Vance, L Sakely, H AF Campbell, A. Coley, K. Thorpe, C. Corbo, J. McGivney, M. Klatt, P. Zaharoff, J. Cox-Vance, L. Sakely, H. TI The impact of pharmacists caring for geriatric patients across the healthcare continuum on the identification, resolution, and prevention of drug therapy problems: A subset of the PIVOTS (Pharmacist-led Interventions on the Transitions of Seniors) Group SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS) CY MAY 10-17, 2015 CL National Harbor, MD SP Amer Geriatr Soc C1 [Campbell, A.; Corbo, J.; Klatt, P.; Cox-Vance, L.; Sakely, H.] UPMC St Margaret, Pittsburgh, PA USA. [Coley, K.; Thorpe, C.; McGivney, M.] Univ Pittsburgh, Pittsburgh, PA USA. [Thorpe, C.] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. [Zaharoff, J.] Presbyterian SeniorCare, Oakmont, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 SU 1 SI SI MA D83 BP S265 EP S265 PG 1 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CF5EL UT WOS:000352578900745 ER PT J AU Chen, P Sun, DM Boockvar, KS Hung, W AF Chen, P. Sun, D. M. Boockvar, K. S. Hung, W. TI Geriatrics Case Teleconference for Rural Healthcare Professionals: Evaluation of Barriers SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS) CY MAY 10-17, 2015 CL National Harbor, MD SP Amer Geriatr Soc C1 [Chen, P.; Boockvar, K. S.; Hung, W.] Icahn Sch Med Mt Sinai, Brookdale Dept Geriatr & Palliat Med, New York, NY 10029 USA. [Sun, D. M.; Boockvar, K. S.; Hung, W.] James J Peters VA Med Ctr, GRECC, Bronx, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 SU 1 SI SI MA A102 BP S53 EP S53 PG 1 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CF5EL UT WOS:000352578900148 ER PT J AU Cheng, J Castle, S Blanchard, E Ines, E Roberts, C Morey, MC Hall, K Deberry, J Valencia-Rodrigo, W Steinbrenner, G Katzel, L Giffuni, J Kopp, T Cammarata, H Lee, CC AF Cheng, J. Castle, S. Blanchard, E. Ines, E. Roberts, C. Morey, M. C. Hall, K. Deberry, J. Valencia-Rodrigo, W. Steinbrenner, G. Katzel, L. Giffuni, J. Kopp, T. Cammarata, H. Lee, C. C. TI Integration of the FallProof Balance Program into the Gerofit Veterans Fitness Program SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS) CY MAY 10-17, 2015 CL National Harbor, MD SP Amer Geriatr Soc C1 [Cheng, J.; Castle, S.; Blanchard, E.; Ines, E.; Roberts, C.; Lee, C. C.] VA Greater Los Angeles, GRECC, Los Angeles, CA USA. [Morey, M. C.; Hall, K.; Deberry, J.] VHA Durham, GRECC, Durham, NC USA. [Valencia-Rodrigo, W.] VHA Miami, GRECC, Miami, FL USA. [Steinbrenner, G.; Katzel, L.; Giffuni, J.] VHA Baltimore, GRECC, Baltimore, MD USA. [Kopp, T.; Cammarata, H.] VAMC Canandaigua, Canandaigua, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 SU 1 SI SI MA D65 BP S258 EP S259 PG 2 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CF5EL UT WOS:000352578900727 ER PT J AU Cummins, J Lyketsos, C Tariot, PN Peskind, ER Nguyen, U Knowles, N Shin, P Siffert, J AF Cummins, J. Lyketsos, C. Tariot, P. N. Peskind, E. R. Nguyen, U. Knowles, N. Shin, P. Siffert, J. TI Dextromethorphan/Quinidine (AVP-923) Efficacy and Safety for Treatment of Agitation in Persons With Alzheimer's Disease: Results From a Phase 2 Study (NCT01584440) SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS) CY MAY 10-17, 2015 CL National Harbor, MD SP Amer Geriatr Soc C1 [Cummins, J.] Cleveland Clin, Lou Ruvo Ctr Brain Hlth, Las Vegas, NV USA. [Lyketsos, C.] Johns Hopkins Med, Baltimore, MD USA. [Tariot, P. N.] Banner Alzheimers Inst, Phoenix, AZ USA. [Peskind, E. R.] VA Puget Sound Hlth Care Syst, Seattle, WA USA. [Nguyen, U.; Knowles, N.; Shin, P.; Siffert, J.] Avanir Pharmaceut Inc, Aliso Viejo, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 SU 1 SI SI MA A42 BP S32 EP S32 PG 1 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CF5EL UT WOS:000352578900088 ER PT J AU Dharia, T Jang, M Schwab, E Ang, K AF Dharia, T. Jang, M. Schwab, E. Ang, K. TI Proton Pump Inhibitor (PPI) Tapering - A Primary Care Difficulty SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS) CY MAY 10-17, 2015 CL National Harbor, MD SP Amer Geriatr Soc C1 [Dharia, T.; Jang, M.; Schwab, E.] Univ Penn, Div Geriatr Med, Philadelphia, PA 19104 USA. [Dharia, T.; Jang, M.; Schwab, E.; Ang, K.] Philadelphia VA Med Ctr, Div Geriatr, Philadelphia, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 SU 1 SI SI MA C132 BP S206 EP S206 PG 1 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CF5EL UT WOS:000352578900578 ER PT J AU Fung, CH Alessi, C Truong, C Josephson, K Hays, R Col, N Patterson, E Martin, J AF Fung, C. H. Alessi, C. Truong, C. Josephson, K. Hays, R. Col, N. Patterson, E. Martin, J. TI Patient-provider communication about sleep apnea: Results from focus groups with older adults SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS) CY MAY 10-17, 2015 CL National Harbor, MD SP Amer Geriatr Soc C1 [Fung, C. H.; Alessi, C.; Truong, C.; Josephson, K.; Martin, J.] VA Greater Los Angeles, Los Angeles, CA USA. [Fung, C. H.; Alessi, C.; Truong, C.; Hays, R.; Martin, J.] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA. [Col, N.] Univ So Maine, Portland, ME 04103 USA. [Patterson, E.] Ohio State Univ, Columbus, OH 43210 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 SU 1 SI SI MA A140 BP S66 EP S66 PG 1 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CF5EL UT WOS:000352578900186 ER PT J AU Greene, M Hessol, N Perissinotto, C Marcotte, T Hutton-Parrott, A Zepf, R Foreman, C Whirry, R Gandhi, M John, M AF Greene, M. Hessol, N. Perissinotto, C. Marcotte, T. Hutton-Parrott, A. Zepf, R. Foreman, C. Whirry, R. Gandhi, M. John, M. TI Loneliness is Associated with Functional Impairment and Health-Related Quality of Life in Older HIV-Positive Adults SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS) CY MAY 10-17, 2015 CL National Harbor, MD SP Amer Geriatr Soc C1 [Greene, M.; Hessol, N.; Perissinotto, C.; Marcotte, T.; Hutton-Parrott, A.; Zepf, R.; Foreman, C.; Gandhi, M.; John, M.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Greene, M.] San Francisco VA Med Ctr, San Francisco, CA USA. [Whirry, R.] Robert Whirry & Associates, Los Angeles, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 SU 1 SI SI MA B176 BP S154 EP S154 PG 1 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CF5EL UT WOS:000352578900429 ER PT J AU Greene, M Cenzer, IS Ahalt, C Williams, B AF Greene, M. Cenzer, I. Stijacic Ahalt, C. Williams, B. TI Older Jail Inmates Experience Early Onset of Geriatric Conditions SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS) CY MAY 10-17, 2015 CL National Harbor, MD SP Amer Geriatr Soc C1 [Greene, M.; Cenzer, I. Stijacic; Ahalt, C.; Williams, B.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Greene, M.; Cenzer, I. Stijacic; Williams, B.] San Francisco VA Med Ctr, San Francisco, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 SU 1 SI SI MA B94 BP S124 EP S124 PG 1 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CF5EL UT WOS:000352578900347 ER PT J AU Hagiwara, Y Ross, J Reilly, A Lee, S Sanchez-Reilly, S AF Hagiwara, Y. Ross, J. Reilly, A. Lee, S. Sanchez-Reilly, S. TI Tough Conversations: Training Medical Students to Lead Family Meetings SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS) CY MAY 10-17, 2015 CL National Harbor, MD SP Amer Geriatr Soc C1 [Hagiwara, Y.; Ross, J.; Sanchez-Reilly, S.] UT Hlth Sci Ctr San Antonio, Geriatr Gerontol & Palliat Med, San Antonio, TX USA. [Ross, J.; Reilly, A.; Lee, S.; Sanchez-Reilly, S.] South Texas Vet Hlth Care Syst, GRECC, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 SU 1 SI SI MA P15 BP S6 EP S6 PG 1 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CF5EL UT WOS:000352578900016 ER PT J AU Horney, C Capp, R Burke, RE Boxer, RS AF Horney, C. Capp, R. Burke, R. E. Boxer, R. S. TI Shorter Length of Hospital Stay Associated with Early Readmissions from Post-Acute Care SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS) CY MAY 10-17, 2015 CL National Harbor, MD SP Amer Geriatr Soc C1 [Horney, C.; Boxer, R. S.] Univ Colorado, Dept Med, Div Geriatr Med, Aurora, CO USA. [Capp, R.] Univ Colorado, Dept Emergency Med, Aurora, CO USA. [Burke, R. E.] Denver VA Med Ctr, Med Serv, Hosp Med Sect, Denver, CO USA. [Burke, R. E.] Univ Colorado, Dept Med, Div Gen Internal Med, Aurora, CO USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 SU 1 SI SI MA B25 BP S99 EP S99 PG 1 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CF5EL UT WOS:000352578900278 ER PT J AU Hsu, A Henderson, JT Harper, CC Sawaya, GF AF Hsu, A. Henderson, J. T. Harper, C. C. Sawaya, G. F. TI Pelvic examinations in older women: practices and beliefs of US obstetrician-gynecologists SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS) CY MAY 10-17, 2015 CL National Harbor, MD SP Amer Geriatr Soc C1 [Hsu, A.] San Francisco VA Med Ctr, San Francisco, CA USA. [Henderson, J. T.] Kaiser Permanente Ctr Hlth Res, Portland, OR USA. [Harper, C. C.; Sawaya, G. F.] Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 SU 1 SI SI MA B164 BP S150 EP S150 PG 1 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CF5EL UT WOS:000352578900417 ER PT J AU Jang, M Schwab, E AF Jang, M. Schwab, E. TI Dementia and the "Great Imitator": Neurosyphilis in a Veteran Presenting with Delirium SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS) CY MAY 10-17, 2015 CL National Harbor, MD SP Amer Geriatr Soc C1 [Jang, M.; Schwab, E.] Univ Penn, Div Geriatr Med, Philadelphia, PA 19104 USA. [Jang, M.; Schwab, E.] Philadelphia Vet Affairs Med Ctr, Div Geriatr, Philadelphia, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 SU 1 SI SI MA A26 BP S26 EP S27 PG 2 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CF5EL UT WOS:000352578900072 ER PT J AU Kennelty, K Troller, P Deniger, A Doh, J Mirr, J Dattalo, M Kind, A AF Kennelty, K. Troller, P. Deniger, A. Doh, J. Mirr, J. Dattalo, M. Kind, A. TI Prevalence of Medication Discrepancies Post-Discharge by Community Pharmacy Type for Older Adult Patients SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS) CY MAY 10-17, 2015 CL National Harbor, MD SP Amer Geriatr Soc C1 [Kennelty, K.; Dattalo, M.; Kind, A.] William S Middleton Mem Vet Adm Med Ctr, Geriatr Res Educ & Clin Ctr, Madison, WI USA. [Troller, P.; Deniger, A.; Dattalo, M.] Univ Wisconsin Hosp & Clin, Madison, WI 53792 USA. [Kennelty, K.; Doh, J.; Mirr, J.; Kind, A.] Univ Wisconsin, Madison, WI USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 SU 1 SI SI MA C151 BP S212 EP S213 PG 2 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CF5EL UT WOS:000352578900597 ER PT J AU Kilpatrick, L Williams, B Harada, C AF Kilpatrick, L. Williams, B. Harada, C. TI Reflections on Frailty from First Year Internal Medicine SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS) CY MAY 10-17, 2015 CL National Harbor, MD SP Amer Geriatr Soc C1 [Kilpatrick, L.] Baylor Scott & White, Temple, TX USA. [Williams, B.; Harada, C.] Univ Alabama Birmingham, Birmingham, AL USA. [Williams, B.; Harada, C.] Birmingham VAMC, Birmingham, AL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 SU 1 SI SI MA A99 BP S51 EP S52 PG 2 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CF5EL UT WOS:000352578900145 ER PT J AU Maggiore, R Callahan, K Parker, I Tooze, J Hsu, T Klepin, H AF Maggiore, R. Callahan, K. Parker, I. Tooze, J. Hsu, T. Klepin, H. TI Cancer Care Training Content of US Geriatric Medicine Fellowship Programs: A Survey of Geriatrics Fellowship Program Directors SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS) CY MAY 10-17, 2015 CL National Harbor, MD SP Amer Geriatr Soc C1 [Maggiore, R.] Portland VA Med Ctr, Portland, OR USA. [Callahan, K.; Tooze, J.; Klepin, H.] Wake Forest Univ, Winston Salem, NC 27109 USA. [Parker, I.] ElderCare Mediat Solut, San Diego, CA USA. [Hsu, T.] Ottawa Hosp, Ctr Canc, Ottawa, ON, Canada. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 SU 1 SI SI MA A107 BP S54 EP S55 PG 2 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CF5EL UT WOS:000352578900153 ER PT J AU Makris, UE Pugh, M Alvarez, CA Mortensen, EM AF Makris, U. E. Pugh, M. Alvarez, C. A. Mortensen, E. M. TI Exposure to High Risk Medications is Associated with Worse Outcomes in Older Veterans with Chronic Pain SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS) CY MAY 10-17, 2015 CL National Harbor, MD SP Amer Geriatr Soc C1 [Makris, U. E.; Alvarez, C. A.; Mortensen, E. M.] Univ Texas SW Med Ctr Dallas, Internal Med, Dallas, TX 75390 USA. [Makris, U. E.; Mortensen, E. M.] VA North Texas Hlth Care Syst, Dallas, TX USA. [Pugh, M.] South Texas Vet Hlth Care Syst, San Antonio, TX USA. [Pugh, M.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Alvarez, C. A.] Texas Tech Univ, Hlth Sci Ctr, Dallas, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 SU 1 SI SI MA A154 BP S71 EP S71 PG 1 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CF5EL UT WOS:000352578900200 ER PT J AU McCaskill, GM Bowen, PG Leeper, P Burgio, KL Clay, OJ AF McCaskill, G. M. Bowen, P. G. Leeper, J. Burgio, K. L. Clay, O. J. TI Predicting Aerobic Activity among Older African Americans with Chronic Conditions SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS) CY MAY 10-17, 2015 CL National Harbor, MD SP Amer Geriatr Soc C1 [McCaskill, G. M.] Birmingham VAMC, Birmingham, AL USA. [Bowen, P. G.; Burgio, K. L.; Clay, O. J.] Univ Alabama Birmingham, Birmingham, AL USA. [Leeper, J.] Univ Alabama, Tuscaloosa, AL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 SU 1 SI SI MA A130 BP S63 EP S63 PG 1 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CF5EL UT WOS:000352578900176 ER PT J AU McElwain, L Brown, C Fix, K Waite, C Booth, KA Markland, AD AF McElwain, L. Brown, C. Fix, K. Waite, C. Booth, K. A. Markland, A. D. TI Documentation and Accessibility of Advance Care Planning Discussions for Home-Based Primary Care Veterans SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS) CY MAY 10-17, 2015 CL National Harbor, MD SP Amer Geriatr Soc C1 [McElwain, L.; Brown, C.; Fix, K.; Booth, K. A.; Markland, A. D.] Univ Alabama Birmingham, Birmingham, AL USA. [McElwain, L.; Fix, K.; Waite, C.] Birmingham VA Med Ctr, Birmingham, AL USA. [Brown, C.; Booth, K. A.; Markland, A. D.] Birmingham Atlanta GRECC, Birmingham, AL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 SU 1 SI SI MA C75 BP S186 EP S186 PG 1 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CF5EL UT WOS:000352578900521 ER PT J AU Miura, L Black, A Franklin, S Pruitt, C Goodlin, S AF Miura, L. Black, A. Franklin, S. Pruitt, C. Goodlin, S. TI Reaching Rural Veterans with Dementia through Telehealth: the Rural Collaborative Dementia Program SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS) CY MAY 10-17, 2015 CL National Harbor, MD SP Amer Geriatr Soc C1 [Miura, L.; Black, A.; Franklin, S.; Pruitt, C.; Goodlin, S.] Portland VA Med Ctr, Med, Portland, OR USA. [Miura, L.; Goodlin, S.] Oregon Hlth & Sci Univ, Med, Portland, OR 97201 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 SU 1 SI SI MA A132 BP S63 EP S64 PG 2 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CF5EL UT WOS:000352578900178 ER PT J AU Ngo, Q Shi, Y Shu, Z Kamat, A AF Ngo, Q. Shi, Y. Shu, Z. Kamat, A. TI Age-Related Alterations in Expression of Key Regulators of Hepatic Lipid Metabolism in a Non-Human Primate Model SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS) CY MAY 10-17, 2015 CL National Harbor, MD SP Amer Geriatr Soc C1 [Ngo, Q.; Shi, Y.; Shu, Z.; Kamat, A.] Univ Texas Hlth Sci Ctr San Antonio, Med, San Antonio, TX 78229 USA. [Shi, Y.; Shu, Z.; Kamat, A.] South Texas Vet Hlth Care Syst, GRECC, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 SU 1 SI SI MA B55 BP S110 EP S110 PG 1 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CF5EL UT WOS:000352578900308 ER PT J AU Noble, S Sanchez-Reilly, S Ross, J AF Noble, S. Sanchez-Reilly, S. Ross, J. TI Facebook as a Resource for Informal Caregivers of Dementia Patients SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS) CY MAY 10-17, 2015 CL National Harbor, MD SP Amer Geriatr Soc C1 [Noble, S.; Sanchez-Reilly, S.; Ross, J.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Noble, S.; Sanchez-Reilly, S.; Ross, J.] South Texas Vet Hlth Care Syst, GEC GRECC, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 SU 1 SI SI MA P6 BP S2 EP S3 PG 2 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CF5EL UT WOS:000352578900007 ER PT J AU Poon, LH Nigro, S Wittkop, E Lee, AJ AF Poon, L. H. Nigro, S. Wittkop, E. Lee, A. J. TI Impact of a geriatric pharmacist conducted hospital discharge follow-up program SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS) CY MAY 10-17, 2015 CL National Harbor, MD SP Amer Geriatr Soc C1 [Poon, L. H.; Nigro, S.; Lee, A. J.] San Francisco VA Med Ctr, Pharm, San Francisco, CA USA. [Poon, L. H.; Lee, A. J.] Univ Pacific, Sch Pharm & Hlth Sci, Stockton, CA 95211 USA. [Wittkop, E.] VA Northern Calif Hlth Care Syst, Pharm, Martinez, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 SU 1 SI SI MA A174 BP S78 EP S78 PG 1 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CF5EL UT WOS:000352578900220 ER PT J AU Rothrock, AG Bearden, D Simmons, E Sawyer, P Brown, C Flood, K AF Rothrock, A. G. Bearden, D. Simmons, E. Sawyer, P. Brown, C. Flood, K. TI Safe Mobility for Older Adults in Acute Care Settings: Simulation Training for Interprofessional Providers SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS) CY MAY 10-17, 2015 CL National Harbor, MD SP Amer Geriatr Soc C1 [Rothrock, A. G.; Bearden, D.; Simmons, E.; Sawyer, P.; Brown, C.; Flood, K.] Univ Alabama Birmingham, Birmingham, AL USA. [Brown, C.] Birmingham Vet Affairs Med Ctr, Birmingham, AL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 SU 1 SI SI MA A79 BP S45 EP S45 PG 1 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CF5EL UT WOS:000352578900125 ER PT J AU Stephens, C Halifax, E Bui, N Lee, SJ Harrington, C Shim, J Ritchie, C AF Stephens, C. Halifax, E. Bui, N. Lee, S. J. Harrington, C. Shim, J. Ritchie, C. TI The Perceived Influence of Family on Nursing Home Resident ER Transfers and Potential Role for Palliative Care and Emerging Health Technologies SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS) CY MAY 10-17, 2015 CL National Harbor, MD SP Amer Geriatr Soc C1 [Lee, S. J.] Univ Calif San Francisco, Geriatr Palliat & Extended Care, San Francisco VA Med Ctr, San Francisco, CA 94143 USA. [Stephens, C.; Halifax, E.; Bui, N.] Univ Calif San Francisco, Community Hlth Syst, San Francisco, CA 94143 USA. [Harrington, C.; Shim, J.] Univ Calif San Francisco, Social & Behav Sci, San Francisco, CA 94143 USA. [Ritchie, C.] Univ Calif San Francisco, Div Geriatr, San Francisco, CA 94143 USA. NR 0 TC 0 Z9 0 U1 1 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 SU 1 SI SI MA C135 BP S207 EP S207 PG 1 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CF5EL UT WOS:000352578900581 ER PT J AU Stephens, C Halifax, E Bui, N Shim, J Ritchie, C Harrington, C Lee, SJ AF Stephens, C. Halifax, E. Bui, N. Shim, J. Ritchie, C. Harrington, C. Lee, S. J. TI "They don't trust us": The Influence of Perceptions of Inadequate Nursing Home Care on ER Transfers and Potential Role for Emerging Health Technologies SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS) CY MAY 10-17, 2015 CL National Harbor, MD SP Amer Geriatr Soc C1 [Lee, S. J.] UC San Francisco, San Francisco VA Med Ctr, Geriatr Palliat & Extended Care, San Francisco, CA USA. [Stephens, C.; Halifax, E.; Bui, N.] Univ Calif San Francisco, Community Hlth Syst, San Francisco, CA 94143 USA. [Shim, J.; Harrington, C.] Univ Calif San Francisco, Social & Behav Sci, San Francisco, CA 94143 USA. [Ritchie, C.] Univ Calif San Francisco, Div Geriatr, San Francisco, CA 94143 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 SU 1 SI SI MA B98 BP S125 EP S126 PG 2 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CF5EL UT WOS:000352578900351 ER PT J AU Wright, RM Rossi, MI Marcum, Z AF Wright, R. M. Rossi, M. I. Marcum, Z. TI The Geriatric Pharmacology QI Project SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS) CY MAY 10-17, 2015 CL National Harbor, MD SP Amer Geriatr Soc C1 [Rossi, M. I.] VA Pittsburgh Healthcare Syst, GRECC, Pittsburgh, PA USA. [Wright, R. M.; Rossi, M. I.; Marcum, Z.] Univ Pittsburgh, Div Geriatr Med, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 SU 1 SI SI MA C111 BP S199 EP S199 PG 1 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CF5EL UT WOS:000352578900557 ER PT J AU Wright, RM Rossi, MI AF Wright, R. M. Rossi, M. I. TI Milestones for an Internal Medicine Residency Geriatrics Rotation SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS) CY MAY 10-17, 2015 CL National Harbor, MD SP Amer Geriatr Soc C1 [Wright, R. M.; Rossi, M. I.] Univ Pittsburgh, Med Geriatr, Pittsburgh, PA USA. [Rossi, M. I.] VA Pittsburgh Healthcare Syst, GRECC, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 SU 1 SI SI MA B70 BP S115 EP S116 PG 2 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CF5EL UT WOS:000352578900323 ER PT J AU Zullo, AR Lee, Y Mor, V Daiello, L Komaiko, K Boscardin, WJ Steinman, M AF Zullo, A. R. Lee, Y. Mor, V. Daiello, L. Komaiko, K. Boscardin, W. J. Steinman, M. TI Beta Blocker Use Among United States Nursing Home Residents After Myocardial Infarction: A National Study SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Meeting Abstract CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS) CY MAY 10-17, 2015 CL National Harbor, MD SP Amer Geriatr Soc C1 [Komaiko, K.; Boscardin, W. J.; Steinman, M.] Univ Calif San Francisco, Div Geriatr, San Francisco, CA 94143 USA. [Komaiko, K.; Boscardin, W. J.; Steinman, M.] San Francisco VA Med Ctr, San Francisco, CA USA. [Zullo, A. R.; Lee, Y.; Mor, V.; Daiello, L.] Brown Univ, Sch Publ Hlth, Dept Hlth Serv Policy & Practice, Providence, RI 02912 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD APR PY 2015 VL 63 SU 1 SI SI MA P19 BP S7 EP S7 PG 1 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CF5EL UT WOS:000352578900020 ER PT J AU Browne, KC Trim, RS Myers, US Norman, SB AF Browne, Kendall C. Trim, Ryan S. Myers, Ursula S. Norman, Sonya B. TI Trauma-Related Guilt: Conceptual Development and Relationship With Posttraumatic Stress and Depressive Symptoms SO JOURNAL OF TRAUMATIC STRESS LA English DT Article ID COGNITIVE-PROCESSING THERAPY; FEMALE RAPE VICTIMS; MULTIDIMENSIONAL MODEL; COMBAT VETERANS; PTSD; SHAME; DISORDER; EXPOSURE; SEVERITY; MILITARY AB Despite high prevalence and concerning associated problems, little effort has been made to conceptualize the construct of posttraumatic guilt. This investigation examined the theoretical model of trauma-related guilt proposed by Kubany and Watson (2003). This model hypothesizes that emotional and physical distress related to trauma memories partially mediates the relationship between guilt cognitions and posttraumatic guilt. Using path analysis, this investigation (a) empirically evaluated relationships hypothesized in Kubany and Watson's model, and (b) extended this conceptualization by evaluating models whereby guilt cognitions, distress, and posttraumatic guilt were related to posttraumatic stress disorder (PTSD) symptoms depression symptom severity. Participants were male U.S. Iraq and Afghanistan veterans (N=149). Results yielded a significant indirect effect from guilt cognitions to posttraumatic guilt via distress, providing support for Kubany and Watson's model ( = .14). Findings suggested distress may be the strongest correlate of PTSD symptoms (=.47) and depression symptoms (=.40), and that guilt cognitions may serve to intensify the relationship between distress and posttraumatic psychopathology. Research is needed to evaluate whether distress specific to guilt cognitions operates differentially on posttraumatic guilt when compared to distress more broadly related to trauma memories. Resumen A pesar de la alta prevalencia y los respectivos problemas asociados, se han realizado pocos esfuerzos para conceptualizar el constructo de culpa postraumatica. Esta investigacion examino el modelo teorico de culpa relacionada al trauma propuesto por Kubany y Warson (2003). Este modelo propone que el sufrimiento emocional y fisico relacionado a las memorias traumaticas media parcialmente la relacion entre las cogniciones de la culpa y la culpa postraumatica. Usando analisis de pautas, esta investigacion: (a) evaluo empiricamente las relaciones planteadas en el modelo de Kubany y Watson y (b) extendio esta conceptualizacion mediante la evaluacion de modelos en los cuales las cogniciones de la culpa, el sufrimiento y la culpa postraumatica estaban relacionadas al Trastorno por Estres Postraumatico (TEPT) y la severidad de los sintomas depresivos. Los participantes fueron hombres veteranos estadounidenses de Iraq y Afganistan (n = 149). Los resultados arrojaron un efecto indirecto significativo desde las cogniciones de la culpa hacia la culpa postraumatica via sufrimiento, apoyando el modelo de Kubany y Watson ( = .14). Los hallazgos sugieren que el sufrimiento puede ser el mas fuerte correlato del TEPT ( = .47) y los sintomas depresivos ( = .40) y que las cogniciones de la culpa pueden contribuir a intensificar la relacion entre el sufrimiento y la psicopatologia postraumatica. Se requiere investigacion para evaluar si el sufrimiento especifico a las cogniciones de la culpa opera diferencialmente en la culpa postraumatica cuando se le compara al sufrimiento relacionado en forma mas amplia a las memorias del trauma. Replicacion del Cuestionario de Historia de Incidente Critico: Frecuencia y Severidad de Exposicion a Trauma entre Oficiales de Agencias Policiales medianas y pequenas. Traditional and Simplified Chinese Abstracts by AsianSTSS ??: ???????????????????????????? ??: ?????????????,???????????,????????????????????????Kubany?Watson (2003)????????????????????????????????????,???????????????????????????????(?)?????Kubany?Watson????????;(?)??????,?????????????????????(PTSD)????????????????????????????????????(N = 149)????????,??????????????????????,?Kubany?Watson????????( =.14)???????,????PTSD ( = .47)?????( = .40) ???????,??????????????????????????????????????,??????????????,????????????????,???????????? ??: ???????????????????????????? ??: ?????????????,???????????,????????????????????????Kubany?Watson (2003)?????????????????????????????????????,???????????????????????????????(?)?????Kubany?Watson????????;(?)??????,?????????????????????(PTSD)????????????????????????????????????(N = 149)????????,??????????????????????,?Kubany?Watson????????( =.14)???????,????PTSD ( = .47)?????( = .40) ???????,??????????????????????????????????????,??????????????,????????????????,???????????? C1 [Browne, Kendall C.] VA Puget Sound Hlth Care Syst, Mental Illness Res Educ & Clin Ctr, Seattle, WA USA. [Browne, Kendall C.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [Trim, Ryan S.] VA San Diego Healthcare Syst, San Diego, CA USA. [Trim, Ryan S.; Norman, Sonya B.] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA. [Myers, Ursula S.] Univ Calif San Diego, San Diego State Univ, Joint Doctoral Program Clin Psychol, San Diego, CA 92103 USA. [Norman, Sonya B.] Natl Ctr PTSD, White River Jct, VT USA. [Norman, Sonya B.] Ctr Excellence Stress & Mental Hlth, San Diego, CA USA. RP Norman, SB (reprint author), VA San Diego, 3350 La Jolla Village Dr,MC116B, San Diego, CA 92161 USA. EM snorman@ucsd.edu FU NIAAA F31 award [5 F31 AA018909-02]; UCSD School of Medicine Faculty Research Award; VA Center of Excellence for Stress and Mental Health FX This material is the result of work supported by an NIAAA F31 award (5 F31 AA018909-02) to Dr. Kendall Browne, by a UCSD School of Medicine Faculty Research Award to Drs. Norman and Allard, by the VA Center of Excellence for Stress and Mental Health, and by resources from the U.S. Department of Veterans Affairs Office of Academic Affiliations, Advanced Fellowship Program in Mental Illness Research and Treatment, the VA Puget Sound Health Care System, Seattle, WA, and the VA San Diego Healthcare System, San Diego, CA. The views expressed in this article are those of the authors and do not represent the views of the Department of Veteran Affairs or the United States government. Authors would like to thank Dr. Sandra Brown, Dr. Joseph Price, Dr. Susan Tate, and Dr. V. Robin Weersing for their contributions to this work. NR 37 TC 4 Z9 4 U1 2 U2 16 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0894-9867 EI 1573-6598 J9 J TRAUMA STRESS JI J. Trauma Stress PD APR PY 2015 VL 28 IS 2 BP 134 EP 141 DI 10.1002/jts.21999 PG 8 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA CF8NJ UT WOS:000352818300007 PM 25864504 ER PT J AU Hixson, JD Van Bebber, SL Bertko, KM AF Hixson, John D. Van Bebber, Stephanie L. Bertko, Kate M. TI Interest in a Digital Health Tool in Veterans With Epilepsy: Results of a Phone Survey SO MILITARY MEDICINE LA English DT Article ID SELF-MANAGEMENT; CHRONIC DISEASE; INTERNET; ADULTS; INFORMATION; PROGRAM; ONLINE; TRIAL AB Objective: Online tools for managing chronic health conditions are becoming increasingly popular. Perceived benefits include ease of use, low costs, and availability but are contingent on patient engagement, Internet access, and digital literacy. This article describes data collected during the recruitment phase of a study evaluating an online self- management platform for epilepsy in a U.S. Veteran population. Methods: We used administrative data to identify and contact Veterans with a likely diagnosis of epilepsy in the Veterans Health Administration (VHA). Veterans who did not respond directly to a mailed invitation were recruited by phone to determine study interest and evaluate digital access. Results: Of the 2,143 Veterans mailed study invitations, phone calls were made to 1,789 who did not specifically decline participation. Among those reached by phone (n = 1,053): 295 (28%) expressed interest in the study and an online tool, 333 (19%) reported a lack of computer and/or Internet access and 425 (40%) were not interested for other reasons. Conclusions: This study suggests an interest in online tools for managing health despite the fact that some Veterans lack computer and/or Internet access. As investment in digital health solutions grows, the VHA should prioritize the widespread provision of digital access to more Veterans. C1 [Hixson, John D.] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94122 USA. [Hixson, John D.; Van Bebber, Stephanie L.; Bertko, Kate M.] San Francisco VA Med Ctr, Epilepsy Ctr Excellence, San Francisco, CA 94121 USA. [Hixson, John D.; Van Bebber, Stephanie L.; Bertko, Kate M.] Northern Calif Inst Res & Educ, San Francisco, CA 94121 USA. RP Hixson, JD (reprint author), Univ Calif San Francisco, Dept Neurol, 400 Parnassus Ave, San Francisco, CA 94122 USA. FU Epilepsy Centers for Excellence (ECoE) Network; San Francisco Veterans Affairs Medical Center FX We acknowledge the support of Dr. Karen Parko and John Haupert in conducting this study. This material is the result of work supported with resources and the use of facilities of the Epilepsy Centers for Excellence (ECoE) Network and the San Francisco Veterans Affairs Medical Center. This study was an industry-sponsored, investigator-initiated trial. NR 19 TC 3 Z9 3 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD APR PY 2015 VL 180 IS 4 BP 387 EP 390 DI 10.7205/MILMED-D-14-00224 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA CF6UJ UT WOS:000352691600005 PM 25826343 ER PT J AU Simon, JH Kinkel, RP Kollman, C O'Connor, P Fisher, E You, X Hyde, R AF Simon, J. H. Kinkel, R. P. Kollman, C. O'Connor, P. Fisher, E. You, X. Hyde, R. CA CHAMPIONS Investigators Grp TI Ten-year follow-up of the 'minimal MRI lesion' subgroup from the original CHAMPS Multiple Sclerosis Prevention Trial SO MULTIPLE SCLEROSIS JOURNAL LA English DT Article DE CHAMPS; CHAMPIONS; disease progression; intramuscular interferon beta-1a; MRI; multiple sclerosis; clinically isolated syndrome ID CLINICALLY ISOLATED SYNDROMES; INTRAMUSCULAR INTERFERON BETA-1A; 1ST DEMYELINATING EVENT; DISABILITY; DEFINITE; MS; CONVERSION AB Background: Patients with clinically isolated syndrome (CIS) and characteristic magnetic resonance imaging (MRI) lesions are at high risk for multiple sclerosis (MS). However, patients with a minimal MRI lesion burden (a low T2-hyperintense [low T2] lesion count) may have borderline formal diagnostic criteria, presenting a clinical management challenge. Objective: Compare the 10-year disease progression of patients with low and higher T2 lesion counts treated over most intervals. Methods: CIS patients from the original CHAMPS MS trial were retrospectively assigned to low-T2 (first quartile; 2-8 lesions) or higher-T2 (second through fourth quartiles; 9 lesions) groups using baseline T2 lesion counts. The 5- and 10-year open-label extension of CHAMPS (CHAMPIONS) evaluated conversion to clinically definite MS (CDMS), MRI activity, relapses, and disability. Results: The vast majority of patients showed new disease activity by MRI and/or clinical criteria at 10 years (low-T2 86%; higher-T2 98%). Fewer low-T2 than higher-T2 patients developed CDMS (40% vs. 63%; p = 0.013); low-T2 patients also had fewer new brain lesions, less brain volume loss, and less disability progression. Conclusion: CIS patients with low T2 lesion counts show continued disease activity. However, all assessments of disease progression over 10 years indicated a significantly less severe disease course for low-T2 patients. C1 [Simon, J. H.] Portland VA Med Ctr, VA Med Ctr, Portland, OR 97239 USA. [Simon, J. H.] Oregon Hlth & Sci Univ, Portland, OR 97239 USA. [Kinkel, R. P.] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA. [Kollman, C.] Jaeb Ctr Hlth Res, Dept Biostat, Tampa, FL USA. [O'Connor, P.] St Michaels Hosp, Multiple Sclerosis Clin, Toronto, ON M5B 1W8, Canada. [Fisher, E.] Cleveland Clin, Dept Biomed Engn, Cleveland, OH 44106 USA. [You, X.] Biogen Idec Inc, Dept Biostat, Cambridge, MA USA. [Hyde, R.] Biogen Idec Inc, Global Med Affairs, Cambridge, MA USA. RP Simon, JH (reprint author), Portland VA Med Ctr, VA Med Ctr, 3710 SW US Vet Rd, Portland, OR 97239 USA. EM jack.simon1@me.com NR 22 TC 3 Z9 3 U1 0 U2 0 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1352-4585 EI 1477-0970 J9 MULT SCLER J JI Mult. Scler. J. PD APR PY 2015 VL 21 IS 4 BP 415 EP 422 DI 10.1177/1352458514547407 PG 8 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA CE9LH UT WOS:000352165000010 PM 25344370 ER PT J AU Wiley, CA Bonneh-Barkay, D Dixon, CE Lesniak, A Wang, GJ Bissel, SJ Kochanek, PM AF Wiley, Clayton A. Bonneh-Barkay, Dafna Dixon, C. Edward Lesniak, Andrew Wang, Guoji Bissel, Stephanie J. Kochanek, Patrick M. TI Role for mammalian chitinase 3-like protein 1 in traumatic brain injury SO NEUROPATHOLOGY LA English DT Article DE BRP-39; chitinase 3-like protein 1; controlled cortical impact; neuroinflammation; traumatic brain injury ID EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; NERVOUS-SYSTEM INFLAMMATION; REACTIVE ASTROCYTES; TRANSGENIC INHIBITION; YKL-40 EXPRESSION; MICE; TISSUE; DEGENERATION; DISEASES; EVOLUTION AB Traumatic brain injury (TBI) is accompanied by inflammatory infiltrates and CNS tissue response. The astrocytosis associated with TBI has been proposed to have both beneficial and detrimental effects on surviving neural tissue. We recently observed prominent astrocytic expression of YKL-40/chitinase 3-like protein 1 (CHI3L1) associated with severity of brain injury. The physiological role of CHI3L1 in the CNS is unknown; however, its distribution at the perimeter of contusions and temporal course of expression suggested that in TBI it might be an important component of the astrocytic response to modulate CNS inflammation. To address this hypothesis, we used serially sectioned brains to quantitatively compare the neuropathological outcomes of TBI produced by controlled cortical impact in wild type (WT) and chi3l1 knockout (KO) mice where the murine YKL-40 homologue, breast regression protein 39 (BRP-39/CHI3l1), had been homozygously disrupted. At 21 days post-injury, chi3l1KO mice displayed greater astrocytosis (increased GFAP staining) in the hemispheres ipsilateral and contralateral to impact compared with WT mice. Similarly, Iba1 expression as a measure of microglial/macrophage response was significantly increased in chi3l1KO compared with WT in the hemisphere contralateral to impact. We conclude that astrocytic expression of CHI3L1 limits the extent of both astrocytic and microglial/macrophage facets of neuroinflammation and suggests a novel potential therapeutic target for modulating neuroinflammation. C1 [Wiley, Clayton A.; Bonneh-Barkay, Dafna; Lesniak, Andrew; Wang, Guoji; Bissel, Stephanie J.] Univ Pittsburgh, Dept Pathol, Pittsburgh, PA 15213 USA. [Dixon, C. Edward] Univ Pittsburgh, VA Pittsburgh Healthcare Syst, Dept Neurosurg Anesthesiol, Pittsburgh, PA 15213 USA. [Dixon, C. Edward] Univ Pittsburgh, VA Pittsburgh Healthcare Syst, Dept Phys Med & Rehabil, Pittsburgh, PA 15213 USA. [Dixon, C. Edward] Univ Pittsburgh, VA Pittsburgh Healthcare Syst, Dept Crit Care Med, Pittsburgh, PA 15213 USA. [Dixon, C. Edward] Univ Pittsburgh, Safar Ctr Resuscitat Res, Dept Neurosurg Anesthesiol, Pittsburgh, PA 15213 USA. [Dixon, C. Edward] Univ Pittsburgh, Safar Ctr Resuscitat Res, Dept Phys Med & Rehabil, Pittsburgh, PA 15213 USA. [Dixon, C. Edward; Kochanek, Patrick M.] Univ Pittsburgh, Safar Ctr Resuscitat Res, Dept Crit Care Med, Pittsburgh, PA 15213 USA. [Kochanek, Patrick M.] Univ Pittsburgh, Safar Ctr Resuscitat Res, Dept Anesthesiol & Pediat, Pittsburgh, PA 15213 USA. RP Wiley, CA (reprint author), Univ Pittsburgh, Dept Pathol, S701 Scaife Hall 200 Lothrop, Pittsburgh, PA 15213 USA. EM wiley1@pitt.edu RI Kochanek, Patrick/D-2371-2015 OI Kochanek, Patrick/0000-0002-2627-913X FU NIH NINDS [NS 070003, NS079061, NS 30318, K24 MH01717]; Pittsburgh Foundation Emmerling funds FX We thank Mark Stauffer, Arlene Carbone-Wiley and Advait Salgarkar for valuable technical assistance. This work was supported, partly by funds from NIH NINDS NS 070003 to PMK; NS079061 to CED; NS 30318 to CED and PMK; K24 MH01717 to CAW, and Pittsburgh Foundation Emmerling funds to DB-B. NR 38 TC 6 Z9 6 U1 1 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0919-6544 EI 1440-1789 J9 NEUROPATHOLOGY JI Neuropathology PD APR PY 2015 VL 35 IS 2 BP 95 EP 106 DI 10.1111/neup.12158 PG 12 WC Clinical Neurology; Neurosciences; Pathology SC Neurosciences & Neurology; Pathology GA CF5WV UT WOS:000352628900001 PM 25377763 ER PT J AU Govani, SM Waljee, AK Stidham, RW Higgins, PDR AF Govani, Shail M. Waljee, Akbar K. Stidham, Ryan W. Higgins, Peter D. R. TI Increasing ultraviolet light exposure is associated with reduced mortality from Clostridium difficile infection SO UNITED EUROPEAN GASTROENTEROLOGY JOURNAL LA English DT Article DE Clostridium difficile; colitis; infectious disease; mortality; risk factors; seasonality; ultraviolet light; vitamin D ID EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; VITAMIN-D DEFICIENCY; RETROSPECTIVE COHORT; RISK; SUPPRESSION; INDEX AB Background: Clostridium difficile infection (CDI) is an increasingly common cause of inpatient mortality. Vitamin D deficiency is associated with more aggressive CDI. We aimed to determine if average annual ultraviolet light (UV) exposure was associated with mortality in patients with CDI. Methods: We used the US National Inpatient Sample (NIS) from 2004-2011 to assess the mortality risk in patients with a diagnosis of CDI (as per ICD-9CM 008.45). Annual average state UV exposure was assigned to each hospitalization. Logistic regression was used to determine the effects of UV exposure on mortality, controlling for age, gender, race and other comorbidities. Results: During the study period, there were 2.61 million hospitalizations with a diagnosis of CDI. The mortality rate was 9.0%. In univariate analysis, the odds ratio (OR) of inpatient mortality for the UV index was 0.97 (95% CI 0.95-0.99; p=0.008) per unit of UV exposure. In a multivariable model adjusting for age, gender, race, Charlson-Deyo index, season and coexisting inflammatory bowel disease, the UV index remained a protective predictor, with an OR of 0.94 (95% CI 0.92-0.96; p<0.001). In the multivariate model, a seasonal effect was also present, with the highest risk of inpatient mortality in the period from January to March (OR 1.11; 95% CI 1.08-1.14) and the lowest risk, from July to September (OR 0.95; 95% CI 0.92-0.98). Conclusions: An increase in UV exposure index is associated with a reduced risk of inpatient mortality in patients with CDI. A seasonal effect is also present, with the highest risk of death during winter months. Further studies exploring the role of UV light in CDI are necessary. C1 [Govani, Shail M.; Waljee, Akbar K.; Stidham, Ryan W.; Higgins, Peter D. R.] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA. [Waljee, Akbar K.] US Dept Vet Affairs, Ctr Clin Management Res, Ann Arbor, MI USA. RP Govani, SM (reprint author), 3912 Taubman Ctr,1500 E Med Ctr Dr,SPC 5362, Ann Arbor, MI 48109 USA. EM shailg@umich.edu RI Waljee, Akbar/G-2067-2010 OI Waljee, Akbar/0000-0003-1964-8790 FU Inflammatory Bowel Disease Working Group; UCB Inc; US Veterans' Administration [1IK2HX000775] FX This work was supported by the Inflammatory Bowel Disease Working Group through an unrestricted educational grant by UCB Inc (GI Fellows Research Award to SMG) and the US Veterans' Administration (VA HSR&D CDA-2 Career Development Award number 1IK2HX000775, to AKS). NR 23 TC 2 Z9 2 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 2050-6406 EI 2050-6414 J9 UNITED EUR GASTROENT JI United European Gastroenterol. J. PD APR PY 2015 VL 3 IS 2 SI SI BP 208 EP 214 DI 10.1177/2050640614567185 PG 7 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA CE9LY UT WOS:000352166700013 PM 25984339 ER PT J AU Patel, R Mikuls, TR Richards, JS Kerr, G Cannon, GW Baker, JF AF Patel, Ruchika Mikuls, Ted R. Richards, John S. Kerr, Gail Cannon, Grant W. Baker, Joshua F. TI Disease Characteristics and Treatment Patterns in Veterans With Rheumatoid Arthritis and Concomitant Hepatitis C Infection SO ARTHRITIS CARE & RESEARCH LA English DT Article ID MODIFYING ANTIRHEUMATIC DRUGS; VIRUS-INFECTION; UNITED-STATES; US VETERANS; MANIFESTATIONS; RECOMMENDATIONS; PREVALENCE; REGISTRY; CRYOGLOBULINEMIA; METHOTREXATE AB ObjectiveTo assess disease characteristics, disease activity, and treatment patterns in rheumatoid arthritis (RA) patients with comorbid hepatitis C virus (HCV) infection. MethodsRA patients with concomitant HCV were identified within the Veterans Affairs Rheumatoid Arthritis Registry. HCV was defined as at least 1 diagnostic code present in medical record databases. Generalized estimating equations in linear regression models compared component and composite measures of disease activity between HCV-positive and HCV-negative patients over the study period, accounting for within-subject correlations. Similar analysis of pharmacy databases evaluated medication use within each group. ResultsNinety-two of 1,706 registry participants (5.1%) were identified with concomitant HCV. At enrollment, HCV-positive patients were younger (mean SD 61.7 +/- 7.1 years versus 67.5 +/- 11.2 years; P < 0.001), more often African American (35% versus 15%; P < 0.001), and smokers (48% versus 26%; P < 0.001). In unadjusted and adjusted analyses incorporating all study visits, patient-reported outcomes (pain, tender joints, and patient global scores) were higher in HCV-positive patients, contributing to higher disease activity scores. There was no difference in physician-reported outcomes (swollen joints or physician global scores). HCV-positive patients had lower C-reactive protein levels ( -0.30 [95% confidence interval (95% CI) -0.53, -0.07], P = 0.01). Over all visits, HCV-positive patients were less likely to receive methotrexate (odds ratio [OR] 0.27 [95% CI 0.17, 0.40], P < 0.001), and more likely to receive prednisone (OR 1.41 [95% CI 1.02, 1.97], P = 0.04) and anti-tumor necrosis factor (anti-TNF) therapies (OR 1.51 [95% CI 1.04, 2.19], P = 0.03). ConclusionRA patients with concomitant HCV have higher disease activity scores, driven primarily by higher patient-reported measures. HCV-positive patients were more likely to be treated with prednisone and anti-TNF therapies and less likely to receive methotrexate compared to HCV-negative patients. C1 [Patel, Ruchika; Baker, Joshua F.] Philadelphia VA Med Ctr, Philadelphia, PA USA. [Patel, Ruchika; Baker, Joshua F.] Univ Penn, Philadelphia, PA 19104 USA. [Mikuls, Ted R.] Nebraska Western Iowa VA Med Ctr, Omaha, NE USA. [Richards, John S.; Kerr, Gail] VA Med Ctr, Washington, DC USA. [Kerr, Gail] Georgetown Univ Hosp, Washington, DC 20007 USA. [Kerr, Gail] Howard Univ Hosp, Washington, DC USA. [Cannon, Grant W.] Salt Lake City VA Med Ctr, Salt Lake City, UT USA. [Cannon, Grant W.] Univ Utah, Salt Lake City, UT USA. RP Baker, JF (reprint author), Hosp Univ Penn, Dept Med, Div Rheumatol, 8 Penn Tower Bldg,34th & Civ Ctr Blvd, Philadelphia, PA 19104 USA. EM bakerjo@uphs.upenn.edu FU Nebraska Arthritis Outcomes Research Center at the University of Nebraska Medical Center; VA Health Services Research and Development Program of the Veterans Health Administration; Abbott Laboratories; Bristol-Myers Squibb; VA Clinical Science Research & Development Career Development Award [IK2 CX000955]; VA Merit Clinical Science Research & Development Career Development Award FX Supported by the Nebraska Arthritis Outcomes Research Center at the University of Nebraska Medical Center. The VA Rheumatoid Arthritis Registry is supported by the VA Health Services Research and Development Program of the Veterans Health Administration and unrestricted research grants from Abbott Laboratories and Bristol-Myers Squibb. Dr. Baker's work was supported by a VA Clinical Science Research & Development Career Development Award (IK2 CX000955). Dr. Mikuls's work was supported by a VA Merit Clinical Science Research & Development Career Development Award. NR 34 TC 1 Z9 2 U1 2 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2151-464X EI 2151-4658 J9 ARTHRIT CARE RES JI Arthritis Care Res. PD APR PY 2015 VL 67 IS 4 BP 467 EP 474 DI 10.1002/acr.22463 PG 8 WC Rheumatology SC Rheumatology GA CE8RM UT WOS:000352111800003 PM 25187185 ER PT J AU Naik, AD Lawrence, B Kiefer, L Ramos, K Utech, A Masozera, N Rao, R Petersen, NJ Kunik, ME Cully, JA AF Naik, Aanand D. Lawrence, Briana Kiefer, Lea Ramos, Katherine Utech, Anne Masozera, Nicholas Rao, Radha Petersen, Nancy J. Kunik, Mark E. Cully, Jeffrey A. TI Building a primary care/research partnership: lessons learned from a telehealth intervention for diabetes and depression SO FAMILY PRACTICE LA English DT Article DE Community-based partnership; formative evaluation; implementation; medical home; primary care ID PARTICIPATORY RESEARCH; IMPLEMENTATION-RESEARCH; PARIHS FRAMEWORK; HEALTH AB Introduction. Evidence-based interventions are often poorly translated into primary care settings due to inadequate integration into organizational cultures and clinical workflows. Study designs that blend evaluation of effectiveness and implementation may enhance uptake of interventions into primary care settings. Community-Based Participatory Research (CBPR) models are useful for developing partnerships between research teams and primary care clinical partners to test blended study designs. Methods. We conducted a formative evaluation of partnership building between a health services research team and a primary care community in US Veterans Affairs Health System to conduct a randomized effectiveness trial of an intervention embedded in routine primary care. The formative evaluation used qualitative data drawn from research/clinical partnership meetings. Data were coded and analysed using qualitative framework analysis. Results. The CBPR model guided development of a research/clinical partnership based on a facilitation team consisting of 'external facilitators' (research team), 'internal facilitators' (primary care leadership) and a ` clinical advisory committee' drawn from the primary care community. Qualitative themes focused on: how the intervention components ('evidence') aligned with local clinical cultures, barriers and facilitators to acceptance and adoption of the intervention processes within the context of clinical workflows and identified ` facilitators' of intervention uptake and sustainability. Conclusion. A CBPR model can guide the development of research/clinical partnerships. Partnerships can identify barriers and craft modifications to intervention procedures that promote integration and into primary care workflows. Formative research/ clinical partnerships are critical for designing and testing interventions focused on implementation and sustainability of new evidence within routine primary care. C1 [Naik, Aanand D.; Lawrence, Briana; Kiefer, Lea; Ramos, Katherine; Petersen, Nancy J.; Kunik, Mark E.; Cully, Jeffrey A.] Michael E DeBakey VA Med Ctr, VA HSR&D Houston Ctr Innovat, Houston, TX USA. [Naik, Aanand D.; Lawrence, Briana; Kiefer, Lea; Ramos, Katherine; Utech, Anne; Petersen, Nancy J.] Baylor Coll Med, Dept Med, Houston, TX 77030 USA. [Naik, Aanand D.] Univ Texas Houston, Sch Publ Hlth, Dept Hlth Promot & Behav Sci, Houston, TX USA. [Lawrence, Briana] Univ Texas Houston, Sch Publ Hlth, Susan G Komen Canc Dispar Trainee, Houston, TX USA. [Ramos, Katherine] Univ Houston, Dept Counseling Psychol, Houston, TX USA. [Utech, Anne; Masozera, Nicholas; Rao, Radha] Michael E DeBakey VA Med Ctr, Primary Care Line, Houston, TX USA. [Kunik, Mark E.; Cully, Jeffrey A.] Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA. [Kunik, Mark E.; Cully, Jeffrey A.] Educ & Clin Ctr, VA South Cent Mental Illness Res, Houston, TX USA. RP Naik, AD (reprint author), Michael E DeBakey VA Med Ctr 152, 2450 Holcombe Blvd,Suite 01Y, Houston, TX 77021 USA. EM anaik@bcm.edu OI Ramos, Katherine/0000-0002-7584-3040 FU Department of Veterans Affairs, Veterans Health Administration, Health Services Research and Development Service project [10-135]; Houston Center for Innovations in Quality, Effectiveness and Safety at the Michael E. DeBakey VA Medical Center [CIN 13-413] FX Department of Veterans Affairs, Veterans Health Administration, Health Services Research and Development Service project (10-135, Naik and Cully, MPIs). Houston Center for Innovations in Quality, Effectiveness and Safety (CIN 13-413) at the Michael E. DeBakey VA Medical Center. NR 19 TC 1 Z9 1 U1 0 U2 12 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0263-2136 EI 1460-2229 J9 FAM PRACT JI Fam. Pr. PD APR PY 2015 VL 32 IS 2 BP 216 EP 223 DI 10.1093/fampra/cmu084 PG 8 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA CF0AH UT WOS:000352204400015 PM 25552674 ER PT J AU Belayev, LY Mor, MK Sevick, MA Shields, AM Rollman, BL Palevsky, PM Arnold, RM Fine, MJ Weisbord, SD AF Belayev, Linda Y. Mor, Maria K. Sevick, Mary Ann Shields, Anne Marie Rollman, Bruce L. Palevsky, Paul M. Arnold, Robert M. Fine, Michael J. Weisbord, Steven D. TI Longitudinal associations of depressive symptoms and pain with quality of life in patients receiving chronic hemodialysis SO HEMODIALYSIS INTERNATIONAL LA English DT Article DE Depressive symptoms; depression; quality of life; pain; symptoms ID STAGE RENAL-DISEASE; CHRONIC KIDNEY-DISEASE; PSYCHOSOCIAL FACTORS; DIALYSIS PATIENTS; MANAGEMENT STRATEGIES; MAJOR DEPRESSION; MORTALITY; ADHERENCE; SEVERITY; SURVIVAL AB Depressive symptoms and pain are common in patients on chronic hemodialysis (HD), yet their associations with quality of life (QOL) are not fully understood. We sought to characterize the longitudinal associations of these symptoms with QOL. As part of a trial comparing two symptom management strategies in patients receiving chronic HD, we assessed depressive symptoms using the Patient Health Questionnaire-9 (PHQ-9), and pain using the Short Form McGill Pain Questionnaire (SF-MPQ) monthly over 24 months. We assessed health-related QOL (HR-QOL) quarterly using the Short Form 12 (SF-12) and global QOL (G-QOL) using a single-item survey. We used random effects linear regression to analyze the independent associations of depressive symptoms and pain, scaled based on 5-point increments in symptom scores, with HR-QOL and G-QOL. Overall, 286 patients completed 1417 PHQ-9 and SF-MPQ symptom assessments, 1361 SF-12 assessments, and 1416 G-QOL assessments. Depressive symptoms were independently and inversely associated with SF-12 physical HR-QOL scores (=-1.09; 95% confidence interval [CI]: -1.69, -0.50, P<0.001); SF-12 mental HR-QOL scores (=-4.52; 95% CI: -5.15, -3.89, P<0.001); and G-QOL scores (=-0.64; 95%CI: -0.79, -0.49, P<0.001). Pain was independently and inversely associated with SF-12 physical HR-QOL scores (=-0.99; 95% CI: -1.30, -0.68, P<0.001) and G-QOL scores (=-0.12; 95%CI: -0.20, -0.05, P=0.002); but not with SF-12 mental HR-QOL scores (=-0.16; 95%CI: -0.050, 0.17, P=0.34). In patients receiving chronic HD, depressive symptoms and to a lesser extent pain, are independently associated with reduced HR-QOL and G-QOL. Interventions to alleviate these symptoms could potentially improve patients' HR-QOL and G-QOL. C1 [Belayev, Linda Y.; Palevsky, Paul M.; Weisbord, Steven D.] Univ Pittsburgh, Sch Med, Dept Med, Div Renal Electrolyte, Pittsburgh, PA 15213 USA. [Rollman, Bruce L.; Arnold, Robert M.; Fine, Michael J.] Univ Pittsburgh, Sch Med, Div Gen Internal Med, Pittsburgh, PA USA. [Arnold, Robert M.] Univ Pittsburgh, Sch Med, Div Palliat Care, Pittsburgh, PA USA. [Palevsky, Paul M.; Weisbord, Steven D.] VA Pittsburgh Healthcare Syst, Renal Sect, Med Serv Line, Pittsburgh, PA 15240 USA. [Mor, Maria K.; Shields, Anne Marie; Fine, Michael J.; Weisbord, Steven D.] VA Pittsburgh Healthcare Syst, Ctr Hlth Equ Res & Promot, Pittsburgh, PA 15240 USA. [Mor, Maria K.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Biostat, Pittsburgh, PA 15261 USA. [Sevick, Mary Ann] NYU, Sch Med, Dept Populat Hlth, New York, NY USA. RP Weisbord, SD (reprint author), VA Pittsburgh Healthcare Syst, 7E Room 120,111F-U, Pittsburgh, PA 15240 USA. EM weisbordsd@upmc.edu OI Palevsky, Paul/0000-0002-7334-5400 FU Department of Veterans Affairs Health Services Research and Development Merit Review award [IIR 07-190]; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases [T32 DK061296] FX S. D. W. was supported by a Department of Veterans Affairs Health Services Research and Development Merit Review award (IIR 07-190) and L. Y. B. was supported by an National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases grant T32 DK061296. NR 54 TC 7 Z9 7 U1 2 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1492-7535 EI 1542-4758 J9 HEMODIAL INT JI Hemodial. Int. PD APR PY 2015 VL 19 IS 2 BP 216 EP 224 DI 10.1111/hdi.12247 PG 9 WC Urology & Nephrology SC Urology & Nephrology GA CF5FR UT WOS:000352582900002 PM 25403142 ER PT J AU Mithal, P Howard, LE Aronson, WJ Kane, CJ Cooperberg, MR Terris, MK Amling, CL Freedland, SJ AF Mithal, Prabhakar Howard, Lauren E. Aronson, William J. Kane, Christopher J. Cooperberg, Matthew R. Terris, Martha K. Amling, Christopher L. Freedland, Stephen J. TI Prostate-specific antigen level, stage or Gleason score: Which is best for predicting outcomes after radical prostatectomy, and does it vary by the outcome being measured? Results from Shared Equal Access Regional Cancer Hospital database SO INTERNATIONAL JOURNAL OF UROLOGY LA English DT Article DE disease progression; mortality; prostatectomy; prostatic neoplasms; risk factors ID BIOCHEMICAL RECURRENCE; SEARCH DATABASE; RISK; MORTALITY AB ObjectivesTo assess the ability of preoperative prostate-specific antigen level, Gleason score and stage to predict prostate cancer outcomes beyond biochemical recurrence, specifically castration-resistant prostate cancer, metastases and prostate cancer-specific mortality in radical prostatectomy patients. MethodsWe carried out a retrospective study of 2735 men in the Shared Equal Access Regional Cancer Hospital database treated by radical prostatectomy from 1988 to 2011 with data available on pathological stage, grade and preoperative prostate-specific antigen. We used Cox hazards analyses to examine the predictive accuracy (c-index) of the preoperative prostate-specific antigen (log-transformed), path Gleason score (7, 3+4, 4+3 and 8-10) and path stage grouping (pT2 negative margins; pT2 positive margins; pT3a negative margins; pT3a positive margins; pT3b; vs positive nodes) to predict biochemical recurrence, castration-resistant prostate cancer, metastases and prostate cancer-specific mortality. ResultsMedian follow up was 8.7years, during which, 937 (34%) had biochemical recurrence, 108 (4%) castration-resistant prostate cancer, 127 (5%) metastases and 68 (2%) prostate cancer-specific mortality. For the outcomes of biochemical recurrence, castration-resistant prostate cancer, metastases and prostate cancer-specific mortality, the c-indices were, respectively: prostate-specific antigen 0.65, 0.66, 0.64 and 0.69; Gleason score 0.66, 0.83, 0.76 and 0.85; and pathological stage group 0.69, 0.76, 0.72 and 0.80. ConclusionsGleason score can predict with very high accuracy prostate cancer-specific mortality in patients undergoing radical prostatectomy. Thus, Gleason score should be given more weight in nomograms to predict prostate cancer-specific mortality. Furthermore, men with a high Gleason score should be given special consideration for adjuvant treatment or referral to clinical trials because of a higher risk of prostate cancer-specific mortality. (c) 2015 The Japanese Urological Association C1 [Mithal, Prabhakar] Univ Rochester, Med Ctr, Dept Urol, Rochester, NY 14642 USA. [Howard, Lauren E.; Freedland, Stephen J.] Duke Univ, Sch Med, Dept Surg, Duke Prostate Ctr,Div Urol Surg, Durham, NC USA. [Howard, Lauren E.; Freedland, Stephen J.] Vet Affairs Med Ctr, Dept Surg, Urol Sect, Durham, NC USA. [Aronson, William J.] Vet Affairs Greater Los Angeles Healthcare Syst, Urol Sect, Dept Surg, Los Angeles, CA USA. [Aronson, William J.] Univ Calif Los Angeles, Sch Med, Dept Urol, Los Angeles, CA USA. [Kane, Christopher J.] Univ Calif San Diego, Med Ctr, Dept Urol, San Diego, CA 92103 USA. [Cooperberg, Matthew R.] Univ Calif San Francisco, Dept Urol, San Francisco, CA USA. [Cooperberg, Matthew R.] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA. [Cooperberg, Matthew R.] Vet Affairs Med Ctr, Dept Surg, Urol Sect, San Francisco, CA 94121 USA. [Terris, Martha K.] Med Coll Georgia, Dept Surg, Vet Affairs Med Ctr, Urol Sect, Augusta, GA 30912 USA. [Terris, Martha K.] Med Coll Georgia, Dept Surg, Div Urol Surg, Augusta, GA 30912 USA. [Amling, Christopher L.] Oregon Hlth & Sci Univ, Dept Surg, Div Urol, Portland, OR 97201 USA. RP Freedland, SJ (reprint author), Cedars Sinai Med Ctr, 8635 West 3rd,Suite 1070W, Los Angeles, CA 90048 USA. EM stephen.freedland@cshs.org OI Terris, Martha/0000-0002-3843-7270 FU Amgen; Abbott; Dendreon; Astellas FX Matthew R Cooperberg is a paid consultant to Amgen, Abbott, Dendreon, Astellas. NR 9 TC 2 Z9 3 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0919-8172 EI 1442-2042 J9 INT J UROL JI Int. J. Urol. PD APR PY 2015 VL 22 IS 4 BP 362 EP 366 DI 10.1111/iju.12704 PG 5 WC Urology & Nephrology SC Urology & Nephrology GA CF0JC UT WOS:000352228500007 PM 25728968 ER PT J AU Jacobs, RL Andrews, CP Ramirez, DA Rather, CG Harper, N Jimenez, F Martinez, H Manoharan, M Carrillo, A Gerardi, M Esch, RE He, W Ahuja, SK AF Jacobs, Robert L. Andrews, Charles P. Ramirez, Daniel A. Rather, Cynthia G. Harper, Nathan Jimenez, Fabio Martinez, Hernan Manoharan, Muthu Carrillo, Andrew Gerardi, Margit Esch, Robert E. He, Weijing Ahuja, Sunil K. TI Symptom dynamics during repeated serial allergen challenge chamber exposures to house dust mite SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Letter ID POLLEN; IGE; IMMUNOTHERAPY; PLACEBO C1 [Jacobs, Robert L.; Andrews, Charles P.; Ramirez, Daniel A.; Rather, Cynthia G.] Biogen Res Chamber, San Antonio, TX 78201 USA. [Harper, Nathan; Jimenez, Fabio; Martinez, Hernan; Manoharan, Muthu; Carrillo, Andrew; Gerardi, Margit; He, Weijing; Ahuja, Sunil K.] South Texas Vet Hlth Care Syst, Vet Adm Ctr Personalized Med, San Antonio, TX USA. [Harper, Nathan; Jimenez, Fabio; Martinez, Hernan; Manoharan, Muthu; Carrillo, Andrew; He, Weijing; Ahuja, Sunil K.] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA. [Ahuja, Sunil K.] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, San Antonio, TX 78229 USA. [Ahuja, Sunil K.] Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem, San Antonio, TX 78229 USA. [Esch, Robert E.] Greer Labs, Lenoir, NC USA. RP Jacobs, RL (reprint author), Biogen Res Chamber, San Antonio, TX 78201 USA. EM robert.jacobs7025@sbcglobal.net NR 13 TC 5 Z9 5 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0091-6749 EI 1097-6825 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD APR PY 2015 VL 135 IS 4 BP 1071 EP 1075 DI 10.1016/j.jaci.2014.09.047 PG 6 WC Allergy; Immunology SC Allergy; Immunology GA CF0MQ UT WOS:000352238600034 PM 25458003 ER PT J AU Schmaling, KB Romano, JM Jensen, MP Wilkinson, CW McPherson, S AF Schmaling, Karen B. Romano, Joan M. Jensen, Mark P. Wilkinson, Charles W. McPherson, Sterling TI Salivary Cortisol Responses to Household Tasks Among Couples With Unexplained Chronic Fatigue SO JOURNAL OF FAMILY PSYCHOLOGY LA English DT Article DE couples; chronic fatigue syndrome; cortisol; relationship satisfaction ID DIURNAL CORTISOL; QUALITY; ISSUES; LIFE AB This study examined salivary cortisol levels in couples in which one member had unexplained chronic fatigue (CF). The couples completed questionnaires and seven household activities in a laboratory setting and provided salivary cortisol samples prior to and immediately after the activities, as well as again after completing additional questionnaires and debriefing. The couples rated their interactions as similar to those at home, suggesting ecological validity, and patients with CF experienced the activities as involving more exertion than did their partners. The multilevel model results indicated that patients with CF had overall lower cortisol levels and flatter slopes across repeated measurements than did their significant others. Patients' and significant others' cortisol concentrations were significantly associated with each other over time. Furthermore, significant others' cortisol was associated with greater relationship satisfaction and greater observed rates of patients' illness/pain behaviors per minute, but patients' levels of cortisol were not associated with relationship variables. This study is the first to examine cortisol in couples with CF; the results are discussed in terms of implications for future research. C1 [Schmaling, Karen B.] Washington State Univ, Dept Psychol, Vancouver, WA 98686 USA. [Romano, Joan M.; Wilkinson, Charles W.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [Jensen, Mark P.] Univ Washington, Dept Rehabil Med, Seattle, WA 98195 USA. [Wilkinson, Charles W.] VA Puget Sound Hlth Care Syst, Ctr Geriatr Res Educ & Clin, Seattle, WA USA. [McPherson, Sterling] Washington State Univ, Sch Nursing, Vancouver, WA 98686 USA. RP Schmaling, KB (reprint author), Washington State Univ, Dept Psychol, 14204 NE Salmon Creek Ave, Vancouver, WA 98686 USA. EM Karen.Schmaling@wsu.edu OI Schmaling, Karen/0000-0003-2085-134X FU Chronic Fatigue Association of Minnesota; National Institutes of Health [U19AI38429]; Geriatric Research, Education and Clinical Center; Research and Development Service of the VA Puget Sound Health Care System, Seattle, Washington FX This study was supported by a grant from the Chronic Fatigue Association of Minnesota and National Institutes of Health Grant U19AI38429 Project 4; Charles W. Wilkinson's work was supported in part by the Geriatric Research, Education and Clinical Center and the Research and Development Service of the VA Puget Sound Health Care System, Seattle, Washington. We acknowledge Elizabeth Colasurdo and Carl Sikkema for performance of the cortisol assays and Bethany Osterman for working with the participants. NR 23 TC 1 Z9 1 U1 3 U2 5 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0893-3200 EI 1939-1293 J9 J FAM PSYCHOL JI J. Fam. Psychol. PD APR PY 2015 VL 29 IS 2 BP 296 EP 301 DI 10.1037/fam0000074 PG 6 WC Psychology, Clinical; Family Studies SC Psychology; Family Studies GA CF1PV UT WOS:000352320700017 PM 25844497 ER PT J AU Olson, APJ Sahni, N Kim, B Dhaliwal, G AF Olson, Andrew P. J. Sahni, Nishant Kim, Benjamin Dhaliwal, Gurpreet TI Not a Textbook Case SO JOURNAL OF HOSPITAL MEDICINE LA English DT Article ID GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY; AUTOIMMUNE HEMOLYTIC-ANEMIA C1 [Olson, Andrew P. J.; Sahni, Nishant] Univ Minnesota, Sch Med, Dept Med, Minneapolis, MN 54555 USA. [Olson, Andrew P. J.] Univ Minnesota, Sch Med, Dept Pediat, Minneapolis, MN 54555 USA. [Kim, Benjamin] Univ Calif San Francisco, Div Hematol Oncol, San Francisco, CA 94143 USA. [Kim, Benjamin; Dhaliwal, Gurpreet] Univ Calif San Francisco, Dept Med, San Francisco, CA USA. [Dhaliwal, Gurpreet] San Francisco VA Med Ctr, Med Serv, San Francisco, CA USA. RP Olson, APJ (reprint author), Univ Minnesota, Sch Med, Div Pediat Hosp Med, Dept Med, 420 Delaware St SE,MMC 741, Minneapolis, MN 55455 USA. EM olso5714@umn.edu NR 14 TC 1 Z9 1 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1553-5592 EI 1553-5606 J9 J HOSP MED JI J. Hosp. Med. PD APR PY 2015 VL 10 IS 4 BP 266 EP 270 DI 10.1002/jhm.2319 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA CF5XU UT WOS:000352631400010 PM 25647462 ER PT J AU Gupta, A Schiros, CG Gaddam, KK Aban, I Denney, TS Lloyd, SG Oparil, S Dell'Italia, LJ Calhoun, DA Gupta, H AF Gupta, A. Schiros, C. G. Gaddam, K. K. Aban, I. Denney, T. S. Lloyd, S. G. Oparil, S. Dell'Italia, L. J. Calhoun, D. A. Gupta, H. TI Effect of spironolactone on diastolic function in hypertensive left ventricular hypertrophy SO JOURNAL OF HUMAN HYPERTENSION LA English DT Article ID PRESERVED EJECTION FRACTION; CHRONIC HEART-FAILURE; MYOCARDIAL FIBROSIS; CARDIAC-FUNCTION; DIETARY-SODIUM; ALDOSTERONE; DYSFUNCTION; INHIBITION; COLLAGEN; DISEASE AB We have previously shown rapid reversal of left ventricular hypertrophy (LVH) with 6 months of spironolactone therapy in patients with resistant hypertension (HTN), preserved left ventricular ejection fraction and no history of heart failure. In this substudy, we investigated the effect of mineralocorticoid receptor blockade with spironolactone on pre-clinical diastolic dysfunction. Thirty-four patients (19 with high and 15 with normal aldosterone levels) were treated with spironolactone and followed with cardiac magnetic resonance with tissue tagging at baseline, 3 and 6 months of treatment. Serum markers of collagen turnover (C-propeptide of type-I procollagen and carboxy-terminal telopeptide of type-I collagen) were measured at baseline and at 6 months. At baseline, patients demonstrated reduced E/A ratio (volumetric normalized peak early filling rate/late filling rate, normalized to left ventricular end-diastolic volume), lower peak early-diastolic mitral annular velocity and lower peak early-diastolic circumferential strain rates compared to the reference values obtained from 45 normal controls without HTN or cardiac disease (all comparisons, P<0.01). No significant change occurred in diastolic filling, relaxation parameters or collagen markers with spironolactone therapy at 6 months irrespective of aldosterone status despite significant reduction in left ventricular mass index in both high-and normal-aldosterone groups. In conclusion, resistant HTN patients with LVH demonstrate significant pre-clinical diastolic dysfunction. Short-term spironolactone therapy may not lead to improvement in diastolic function despite rapid reversal of LVH. C1 [Gupta, A.; Schiros, C. G.; Gaddam, K. K.; Lloyd, S. G.; Oparil, S.; Dell'Italia, L. J.; Calhoun, D. A.; Gupta, H.] Univ Alabama Birmingham, Dept Med, Div Cardiovasc Dis, Birmingham, AL 35294 USA. [Aban, I.] Univ Alabama Birmingham, Dept Biostat, Birmingham, AL 35294 USA. [Denney, T. S.] Auburn Univ, Dept Elect & Comp Engn, Auburn, AL 36849 USA. [Lloyd, S. G.; Dell'Italia, L. J.; Gupta, H.] Birmingham Vet Affairs Med Ctr, Birmingham, AL USA. RP Gupta, H (reprint author), CVMRI, FACC BDB 101, 1530 3rd Ave South, Birmingham, AL 35294 USA. EM hgupta@uab.edu FU NIH [P50-HL077100, R01-HL104018] FX This study was funded by NIH grants P50-HL077100 (to LJD) and R01-HL104018 (to HG). NR 27 TC 6 Z9 6 U1 4 U2 5 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0950-9240 EI 1476-5527 J9 J HUM HYPERTENS JI J. Hum. Hypertens. PD APR PY 2015 VL 29 IS 4 BP 241 EP 246 DI 10.1038/jhh.2014.83 PG 6 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA CF4CW UT WOS:000352497200007 PM 25231508 ER PT J AU Mulshine, JL Gierada, DS Armato, SG Avila, RS Yankelevitz, DF Kazerooni, EA McNitt-Gray, MF Buckler, AJ Sullivan, DC AF Mulshine, James L. Gierada, David S. Armato, Samuel G., III Avila, Rick S. Yankelevitz, David F. Kazerooni, Ella A. McNitt-Gray, Michael F. Buckler, Andrew J. Sullivan, Daniel C. TI Role of the Quantitative Imaging Biomarker Alliance in Optimizing CT for the Evaluation of Lung Cancer Screen-Detected Nodules SO JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY LA English DT Article DE Lung cancer screening; pulmonary nodules; quantitative imaging biomarker; low-dose CT scans; metrology ID VOLUMETRIC CT; INTEROBSERVER; VARIABILITY; GUIDELINES; RATES AB The Quantitative Imaging Biomarker Alliance (QIBA) is a multidisciplinary consortium sponsored by the RSNA to define processes that enable the implementation and advancement of quantitative imaging methods described in a QIBA profile document that outlines the process to reliably and accurately measure imaging features. A QIBA profile includes factors such as technical (product-specific) standards, user activities, and relationship to a clinically meaningful metric, such as with nodule measurement in the course of CT screening for lung cancer. In this report, the authors describe how the QIBA approach is being applied to the measurement of small pulmonary nodules such as those found during low-dose CT-based lung cancer screening. All sources of variance with irnaging measurement were defined for this process. Through a process of experimentation, literature review, and assembly of expert opinion, the strongest evidence was used to define how to best implement each step in the imaging acquisition and evaluation process. This systematic approach to implementing a quantitative imaging biomarker with standardized specifications for image acquisition and postprocessing for a specific quantitative measurement of a pulmonary nodule results in consistent performance characteristics of the measurement (eg, bias and variance). Implementation of the QIBA small nodule profile may allow more efficient and effective clinical management of the diagnostic workup of individuals found to have suspicious pulmonary nodules in the course of lung cancer screening evaluation. C1 [Mulshine, James L.] Rush Univ, Chicago, IL 60612 USA. [Gierada, David S.] Washington Univ, Sch Med, Mallinckrodt Inst Radiol, St Louis, MO USA. [Armato, Samuel G., III] Univ Chicago, Dept Radiol, Chicago, IL 60637 USA. [Avila, Rick S.] US Dept Vet Affairs, Washington, DC USA. [Yankelevitz, David F.] Mt Sinai Sch Med, Dept Radiol, New York, NY USA. [Kazerooni, Ella A.] Univ Michigan Hosp, Dept Radiol, Ann Arbor, MI 48109 USA. [McNitt-Gray, Michael F.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiol, Los Angeles, CA 90095 USA. [Buckler, Andrew J.] Elucid Bioimaging Inc, Wenham, MA USA. [Sullivan, Daniel C.] Duke Univ, Dept Radiol, Durham, NC 27710 USA. RP Mulshine, JL (reprint author), Rush Univ, 1735 W Harrison St,Suite 206, Chicago, IL 60612 USA. EM jmulshin@rush.edu OI Buckler, Andrew/0000-0002-0786-4835 NR 29 TC 5 Z9 5 U1 1 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1546-1440 J9 J AM COLL RADIOL JI J. Am. Coll. Radiol. PD APR PY 2015 VL 12 IS 4 BP 390 EP 395 DI 10.1016/j.jacr.2014.12.003 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA CE9RL UT WOS:000352181000016 PM 25842017 ER PT J AU Havens, K Ertl, K Moin, T Vasti, E Makki, F Hughes, M Youles, B Damschroder, L Richardson, C AF Havens, Kathryn Ertl, Kristyn Moin, Tannaz Vasti, Elena Makki, Fatima Hughes, Maria Youles, Bradley Damschroder, Laura Richardson, Caroline TI Women Veterans' Early Experiences with a Web-Based Diabetes Prevention Program SO JOURNAL OF WOMENS HEALTH LA English DT Meeting Abstract C1 [Havens, Kathryn] Zablocki VA Med Ctr, Milwaukee, WI USA. [Ertl, Kristyn] Med Coll Wisconsin, Ctr Patient Care & Outcomes Res, Milwaukee, WI 53226 USA. [Moin, Tannaz; Vasti, Elena] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. [Makki, Fatima; Hughes, Maria; Youles, Bradley; Damschroder, Laura; Richardson, Caroline] VA Ann Arbor Ctr Clin Management Res, Ann Arbor, MI USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-9996 EI 1931-843X J9 J WOMENS HEALTH JI J. Womens Health PD APR 1 PY 2015 VL 24 IS 4 MA P41 BP 17 EP 18 PG 2 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Obstetrics & Gynecology; Women's Studies SC Public, Environmental & Occupational Health; General & Internal Medicine; Obstetrics & Gynecology; Women's Studies GA CF5YE UT WOS:000352632500042 ER PT J AU Yadav, P Leung, N Sanders, PW Cockwell, P AF Yadav, Punit Leung, Nelson Sanders, Paul W. Cockwell, Paul TI The use of immunoglobulin light chain assays in the diagnosis of paraprotein-related kidney disease SO KIDNEY INTERNATIONAL LA English DT Review DE monoclonal gammopathy; monoclonal gammopathy of renal significance; multiple myeloma; serum free light chains ID URINE IMMUNOFIXATION ELECTROPHORESIS; MONOCLONAL GAMMOPATHIES; MULTIPLE-MYELOMA; UNDETERMINED SIGNIFICANCE; PROTEIN ELECTROPHORESIS; QUANTITATIVE ASSESSMENT; AL-AMYLOIDOSIS; SERUM; COMBINATION; POPULATION AB Kidney involvement is common in paraprotein-related diseases. A diversity of clinical presentations and histopathological features can occur secondary to tissue injury caused by precipitation or deposition of a clonal immunoglobulin, usually an immunoglobulin light chain. The paraprotein is either produced by multiple myeloma or by a clone of B-cell lineage that does not fulfill diagnostic criteria for multiple myeloma. The recent introduction of serum immunoglobulin free light chain assays, which accurately quantify both light chain isotypes to produce a ratio that indicates the presence or absence of a light chain paraprotein, is a major clinical development. However, as the interpretation of the assay can be challenging, the aim of this review is to clarify the role of serum and urinary light chain assays in the screening and diagnosis of paraprotein-related kidney disease. C1 [Yadav, Punit; Cockwell, Paul] Queen Elizabeth Hosp, Dept Renal Med, Birmingham B15 2WB, W Midlands, England. [Yadav, Punit; Cockwell, Paul] Univ Birmingham, Coll Med & Dent Sci, Div Immun & Infect, Birmingham, W Midlands, England. [Leung, Nelson] Mayo Clin, Div Nephrol & Hypertens, Rochester, MN USA. [Leung, Nelson] Mayo Clin, Div Haematol, Rochester, MN USA. [Sanders, Paul W.] Univ Alabama Birmingham, Dept Med, Div Nephrol, Birmingham VA Med Ctr, Birmingham, AL 35294 USA. RP Cockwell, P (reprint author), Queen Elizabeth Hosp, Dept Renal Med, Mindelsohn Way, Birmingham B15 2WB, W Midlands, England. EM paul.cockwell@uhb.nhs.uk OI Cockwell, Paul/0000-0003-1975-266X; Leung, Nelson/0000-0002-5651-1411 FU CSRD VA [I01 CX001326]; NIDDK NIH HHS [P30 DK079337] NR 29 TC 2 Z9 2 U1 0 U2 6 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0085-2538 EI 1523-1755 J9 KIDNEY INT JI Kidney Int. PD APR PY 2015 VL 87 IS 4 BP 692 EP 697 DI 10.1038/ki.2014.333 PG 6 WC Urology & Nephrology SC Urology & Nephrology GA CE9QZ UT WOS:000352179800007 PM 25296094 ER PT J AU Ortega, M Bhatnagar, H Lin, AP Wang, L Aster, JC Sill, H Aguiar, RCT AF Ortega, M. Bhatnagar, H. Lin, A-P Wang, L. Aster, J. C. Sill, H. Aguiar, R. C. T. TI A microRNA-mediated regulatory loop modulates NOTCH and MYC oncogenic signals in B- and T-cell malignancies SO LEUKEMIA LA English DT Article ID C-MYC; MYELOID-LEUKEMIA; LYMPHOMA; MUTATIONS; CANCER; PATHWAY; TARGET; TUMORIGENESIS; PROGRESSION; ACTIVATION AB Growing evidence suggests that microRNAs (miRNAs) facilitate the cross-talk between transcriptional modules and signal transduction pathways. MYC and NOTCH1 contribute to the pathogenesis of lymphoid malignancies. NOTCH induces MYC, connecting two signaling programs that enhance oncogenicity. Here we show that this relationship is bidirectional and that MYC, via a miRNA intermediary, modulates NOTCH. MicroRNA-30a (miR-30a), a member of a family of miRNAs that are transcriptionally suppressed by MYC, directly binds to and inhibits NOTCH1 and NOTCH2 expression. Using a murine model and genetically modified human cell lines, we confirmed that miR-30a influences NOTCH expression in a MYC-dependent fashion. In turn, through genetic modulation, we demonstrated that intracellular NOTCH1 and NOTCH2, by inducing MYC, suppressed miR-30a. Conversely, pharmacological inhibition of NOTCH decreased MYC expression and ultimately de-repressed miR-30a. Examination of genetic models of gain and loss of miR-30a in diffuse large B-cell lymphoma (DLBCL) and T-acute lymphoblastic leukemia (T-ALL) cells suggested a tumor-suppressive role for this miRNA. Finally, the activity of the miR-30a-NOTCH-MYC loop was validated in primary DLBCL and T-ALL samples. These data define the presence of a miRNA-mediated regulatory circuitry that may modulate the oncogenic signals originating from NOTCH and MYC. C1 [Ortega, M.; Bhatnagar, H.; Lin, A-P; Wang, L.; Aguiar, R. C. T.] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, Div Hematol & Med Oncol, San Antonio, TX 78229 USA. [Aster, J. C.] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA. [Aster, J. C.] Harvard Univ, Sch Med, Boston, MA USA. [Sill, H.] Med Univ Graz, Div Hematol, Graz, Austria. [Aguiar, R. C. T.] Univ Texas Hlth Sci Ctr San Antonio, Canc Therapy & Res Ctr, San Antonio, TX 78229 USA. [Aguiar, R. C. T.] Univ Texas Hlth Sci Ctr San Antonio, Greehey Childrens Canc Res Inst, San Antonio, TX 78229 USA. [Aguiar, R. C. T.] Audie Murphy VA Hosp, South Texas Vet Hlth Care Syst, San Antonio, TX USA. RP Aguiar, RCT (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Med, Div Hematol & Med Oncol, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA. EM aguiarr@uthscsa.edu OI Sill, Heinz/0000-0003-0993-4371 FU National Cancer Institute [R01-CA138747]; Veterans Administration Merit Award [I01-BX001882]; National Cancer Institute Cancer Center Support Grant [P30 CA054174] FX We thank H Bouamar for technical help in generating the microRNA sponges, A Weng for suggestions and the Flow Cytometry Shared Resource Facility at UTHSCSA for the cell sorting. This work was supported by a grant from the National Cancer Institute (R01-CA138747), a Veterans Administration Merit Award (I01-BX001882) and a National Cancer Institute Cancer Center Support Grant (P30 CA054174). NR 38 TC 9 Z9 11 U1 1 U2 3 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0887-6924 EI 1476-5551 J9 LEUKEMIA JI Leukemia PD APR PY 2015 VL 29 IS 4 BP 968 EP 976 DI 10.1038/leu.2014.302 PG 9 WC Oncology; Hematology SC Oncology; Hematology GA CF5GY UT WOS:000352586700025 PM 25311243 ER PT J AU Jimeno, A Bauman, JE Weissman, C Adkins, D Schnadig, I Beauregard, P Bowles, DW Spira, A Levy, B Seetharamu, N Hausman, D Walker, L Rudin, CM Shirai, K AF Jimeno, Antonio Bauman, Julie E. Weissman, Charles Adkins, Douglas Schnadig, Ian Beauregard, Patrice Bowles, Daniel W. Spira, Alexander Levy, Benjamin Seetharamu, Nagashree Hausman, Diana Walker, Luke Rudin, Charles M. Shirai, Keisuke TI A randomized, phase 2 trial of docetaxel with or without PX-866, an irreversible oral phosphatidylinositol 3-kinase inhibitor, in patients with relapsed or metastatic head and neck squamous cell cancer SO ORAL ONCOLOGY LA English DT Article DE PIK3CA; PI3K; Docetaxel; Head and neck squamous cell cancer ID ADVANCED SOLID TUMORS; I PI3K INHIBITOR; LUNG-CANCER; PIK3CA GENE; MUTATIONS; CARCINOMA; PATHWAY; DRUG AB Introduction: The phosphotidylinositol-3 kinase (PI3K)/serine-threonine kinase (AKT)/mammalian target of rapamycin (mTOR) signaling pathway is frequently altered in head and neck squamous cell cancer (HNSCC). PX-866 is an oral, irreversible, pan-isoform inhibitor of PI3K. Preclinical models revealed synergy with docetaxel and a phase 1 trial demonstrated tolerability of this combination. This randomized phase 2 study evaluated PX-866 combined with docetaxel in patients with advanced, refractory HNSCC. Methods: Patients with locally advanced, recurrent or metastatic HNSCC who had received at least one and no more than two prior systemic treatment regimens were randomized (1: 1) to a combination of docetaxel (75 mg/m(2) IV every 21 days) with or without PX-866 (8 mg PO daily; Arms A and B, respectively). The primary endpoint was progression free survival (PFS). Secondary endpoints included objective response rate (RR), overall survival (OS), toxicity, and correlation of biomarker analyses with efficacy outcomes. Results: 85 patients were enrolled. There was a non-significant improvement in response rate in the combination arm (14% vs. 5%; P = 0.13). Median PFS was 92 days in Arm A and 82 days in Arm B (P = 0.42). There was no difference in OS between the two arms (263 vs. 195 days; P = 0.62). Grade 3 or higher adverse events were infrequent, but more common in the combination arm with respect to diarrhea (17% vs. 2%), nausea (7% vs. 0%), and febrile neutropenia (21% vs. 5%); grade 3 or higher anemia was more frequent in arm B (7% vs. 27%). PIK3CA mutations or PTEN loss were infrequently observed. Conclusion: The addition of PX-866 to docetaxel did not improve PFS, RR, or OS in patients with advanced, refractory HNSCC without molecular pre-selection. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Jimeno, Antonio; Bowles, Daniel W.] Univ Colorado, Sch Med, Aurora, CO 80045 USA. [Bauman, Julie E.] Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA. [Weissman, Charles] New York Hematol, New York, NY USA. [Adkins, Douglas] Washington Univ, St Louis, MO USA. [Schnadig, Ian] Compass Oncol, Tualatin, OR USA. [Schnadig, Ian; Spira, Alexander] US Oncol Res, The Woodlands, TX USA. [Beauregard, Patrice] CHUS Hop Fleurimont, Quebec City, PQ, Canada. [Bowles, Daniel W.] Denver Vet Affairs Med Ctr, Denver, CO USA. [Spira, Alexander] Virginia Canc Specialists, Fairfax, VA USA. [Levy, Benjamin] St Lukes Hosp, Beth Israel Hosp, Mt Sinai Hlth Syst, New York, NY USA. [Seetharamu, Nagashree] NYU, New York, NY USA. [Hausman, Diana; Walker, Luke] Oncothyreon Inc, Seattle, WA USA. [Rudin, Charles M.] Johns Hopkins Univ, Baltimore, MD USA. [Shirai, Keisuke] Med Univ S Carolina, Charleston, SC 29425 USA. RP Jimeno, A (reprint author), Univ Colorado, Sch Med, Div Med Oncol, 12801 East 17th Ave,MS8117, Aurora, CO 80045 USA. EM antonio.jimeno@ucdenver.edu FU Oncothyreon Inc. FX This clinical trial was sponsored by Oncothyreon Inc. No funding was received from the NIH, Wellcome Trust or HHMI. NR 33 TC 14 Z9 14 U1 0 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1368-8375 EI 1879-0593 J9 ORAL ONCOL JI Oral Oncol. PD APR PY 2015 VL 51 IS 4 BP 383 EP 388 DI 10.1016/j.oraloncology.2014.12.013 PG 6 WC Oncology; Dentistry, Oral Surgery & Medicine SC Oncology; Dentistry, Oral Surgery & Medicine GA CE7JX UT WOS:000352016600014 PM 25593016 ER PT J AU Selzman, KA Banks, T Bodtcher, R Keung, E AF Selzman, Kimberly A. Banks, Thomas Bodtcher, Roy Keung, Edmond TI Pacemakers at the Elective Replacement Indicator with a Normal Magnet Rate on Transtelephonic Monitoring SO PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY LA English DT Article DE pacemaker; transtelephonic; elective replacement indicator; ERI; magnet rate; battery voltage C1 [Selzman, Kimberly A.; Banks, Thomas; Bodtcher, Roy] Vet Affairs Med Ctr, George E Wahlen Dept, Div Cardiol, Salt Lake City, UT 84148 USA. [Selzman, Kimberly A.] Univ Utah, Sch Med, Div Cardiol, Salt Lake City, UT USA. [Keung, Edmond] San Francisco VA Med Ctr, Div Cardiol, San Francisco, CA USA. RP Selzman, KA (reprint author), Vet Affairs Med Ctr, George E Wahlen Dept, Div Cardiol, VA 500 Foothill Blvd, Salt Lake City, UT 84148 USA. EM kimberly.selzman@va.gov NR 3 TC 1 Z9 1 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0147-8389 EI 1540-8159 J9 PACE JI PACE-Pacing Clin. Electrophysiol. PD APR PY 2015 VL 38 IS 4 BP 522 EP 525 DI 10.1111/pace.12415 PG 4 WC Cardiac & Cardiovascular Systems; Engineering, Biomedical SC Cardiovascular System & Cardiology; Engineering GA CF1FB UT WOS:000352288100017 PM 24787276 ER PT J AU Simmonds, MJ Finley, EP Vale, S Pugh, MJ Turner, BJ AF Simmonds, Maureen J. Finley, Erin P. Vale, Shruthi Pugh, Mary Jo Turner, Barbara J. TI A Qualitative Study of Veterans on Long-Term Opioid Analgesics: Barriers and Facilitators to Multimodality Pain Management SO PAIN MEDICINE LA English DT Article DE Chronic Pain; Alternative Therapies; Narcotics; Veterans ID CHRONIC NONCANCER PAIN; LOW-BACK-PAIN; PLANNED BEHAVIOR; RANDOMIZED-TRIAL; THERAPY; GUIDELINES; OVERDOSE; SUPPORT; HEALTH AB ObjectiveThe aim of this study was to examine barriers and facilitators to multimodality chronic pain care among veterans on high-dose opioid analgesics for chronic non-cancer pain. SettingA Veterans Health Administration clinic in San Antonio. ParticipantsTwenty-five veterans taking at least 50mg morphine equivalent daily oral opioid doses for more than 6months. MethodsThree semi-structured focus groups, each with seven to nine veterans. Interview guide addressed: chronic pain effects on quality of life, attitudes/experiences with multimodality pain care, social support, and interest in peer support. In an iterative process using grounded theory, three reviewers reviewed de-identified transcripts for themes. The theory of planned behavior (TPB) framework was used to classify barriers and facilitators to multimodal pain management. Main ResultsThe 25 participants had a mean age of 54years (39-70); 32% were women and 24% non-white. The three TPB dimensions (attitudes, social norms, and perceived behavioral control) were reflected in emergent themes: 1) uncontrollable impact of pain in all aspects of life; 2) reliance on opioids and challenges in obtaining these drugs despite ambivalence about benefits; 3) poor access to and beliefs about non-pharmacologic therapies; 4) frustrations with Department of Veterans Affairs health care; and 5) poor social support and isolation reflected by limited interest in peer support. ConclusionsVeterans with chronic pain on long-term opioids hold pervasive attitudes that prevent them from using multimodality pain management options, lack social support and social norms for non-opioid-based pain treatment options, and have poor perceived control due to poor access to multimodality care. C1 [Simmonds, Maureen J.; Finley, Erin P.; Vale, Shruthi; Pugh, Mary Jo; Turner, Barbara J.] Univ Texas Hlth Sci Ctr San Antonio, Res Adv Community Hlth Ctr ReACH Ctr, San Antonio, TX 78229 USA. [Simmonds, Maureen J.; Finley, Erin P.; Pugh, Mary Jo; Turner, Barbara J.] South Texas Vet Hlth Care Syst, Vet Evidence Based Res Disseminat & Implementat C, San Antonio, TX USA. [Finley, Erin P.; Pugh, Mary Jo] Univ Texas Sch Publ Hlth, Houston, TX USA. RP Turner, BJ (reprint author), Univ Texas Hlth Sci Ctr San Antonio, ReACH Ctr, 7411 John Smith Rd,Suite 1050, San Antonio, TX 78229 USA. EM turner@uthscsa.edu OI Pugh, Mary Jo/0000-0003-4196-7763; Finley, Erin/0000-0003-4497-7721 FU Elizabeth Huth Coates Charitable Foundation of 1992 FX We gratefully acknowledge funding from the Elizabeth Huth Coates Charitable Foundation of 1992. We also would like to thank Gregorio E. Pedroza III, MD, for his invaluable help in conducting this study. NR 29 TC 7 Z9 7 U1 2 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1526-2375 EI 1526-4637 J9 PAIN MED JI Pain Med. PD APR PY 2015 VL 16 IS 4 BP 726 EP 732 DI 10.1111/pme.12626 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA CF5SP UT WOS:000352617600015 PM 25528887 ER PT J AU Barger, JL Anderson, RM Newton, MA da Silva, C Vann, JA Pugh, TD Someya, S Prolla, TA Weindruch, R AF Barger, Jamie L. Anderson, Rozalyn M. Newton, Michael A. da Silva, Cristina Vann, James A. Pugh, Thomas D. Someya, Shinichi Prolla, Tomas A. Weindruch, Richard TI A Conserved Transcriptional Signature of Delayed Aging and Reduced Disease Vulnerability Is Partially Mediated by SIRT3 SO PLOS ONE LA English DT Article ID EXTENDS LIFE-SPAN; CALORIC RESTRICTION; GENE-EXPRESSION; INSULIN-RESISTANCE; DIETARY RESTRICTION; SKELETAL-MUSCLE; ADIPOSE-TISSUE; RHESUS-MONKEYS; MICE; METABOLISM AB Aging is the most significant risk factor for a range of diseases, including many cancers, neurodegeneration, cardiovascular disease, and diabetes. Caloric restriction (CR) without malnutrition delays aging in diverse species, and therefore offers unique insights into age-related disease vulnerability. Previous studies suggest that there are shared mechanisms of disease resistance associated with delayed aging, however quantitative support is lacking. We therefore sought to identify a common response to CR in diverse tissues and species and determine whether this signature would reflect health status independent of aging. We analyzed gene expression datasets from eight tissues of mice subjected to CR and identified a common transcriptional signature that includes functional categories of mitochondrial energy metabolism, inflammation and ribosomal structure. This signature is detected in flies, rats, and rhesus monkeys on CR, indicating aspects of CR that are evolutionarily conserved. Detection of the signature in mouse genetic models of slowed aging indicates that it is not unique to CR but rather a common aspect of extended longevity. Mice lacking the NAD-dependent deacetylase SIRT3 fail to induce mitochondrial and anti-inflammatory elements of the signature in response to CR, suggesting a potential mechanism involving SIRT3. The inverse of this transcriptional signature is detected with consumption of a high fat diet, obesity and metabolic disease, and is reversed in response to interventions that decrease disease risk. We propose that this evolutionarily conserved, tissue-independent, transcriptional signature of delayed aging and reduced disease vulnerability is a promising target for developing therapies for age-related diseases. C1 [Barger, Jamie L.; da Silva, Cristina; Prolla, Tomas A.; Weindruch, Richard] LifeGen Technol LLC, Madison, WI 53719 USA. [Anderson, Rozalyn M.; Pugh, Thomas D.; Weindruch, Richard] Univ Wisconsin, Dept Med, SMPH, Madison, WI USA. [Anderson, Rozalyn M.; Weindruch, Richard] William S Middleton Mem Vet Adm Med Ctr, Geriatr Res, Educ & Clin Ctr, Madison, WI USA. [Newton, Michael A.] Univ Wisconsin, Dept Stat, Madison, WI 53706 USA. [Newton, Michael A.] Univ Wisconsin, Dept Biostat & Med Informat, Madison, WI USA. [Vann, James A.; Someya, Shinichi; Prolla, Tomas A.] Univ Wisconsin, Dept Genet, Madison, WI 53706 USA. [Vann, James A.; Someya, Shinichi; Prolla, Tomas A.] Univ Wisconsin, Dept Med Genet, Madison, WI 53706 USA. RP Barger, JL (reprint author), LifeGen Technol LLC, Madison, WI 53719 USA. EM Jamie.L.Barger@gmail.com FU National Institute on Aging [R01AG037000, P01AG011915, R01AG038679]; National Institute of General Medical Sciences [R21HG006568]; LifeGen Technologies, LLC FX Funding was provided by National Institute on Aging R01AG037000 (RMA), National Institute on Aging P01AG011915 (RW), National Institute of General Medical Sciences R21HG006568 (MAN), and National Institute on Aging R01AG038679 (TAP). LifeGen Technologies, LLC, provided support in the form of salaries for authors JLB and CdS, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the 'author contributions' section. NR 58 TC 5 Z9 5 U1 3 U2 13 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 1 PY 2015 VL 10 IS 4 AR UNSP e0120738 DI 10.1371/journal.pone.0120738 PG 15 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CE9AM UT WOS:000352135600037 PM 25830335 ER PT J AU Winnier, DA Fourcaudot, M Norton, L Abdul-Ghani, MA Hu, SL Farook, VS Coletta, DK Kumar, S Puppala, S Chittoor, G Dyer, TD Arya, R Carless, M Lehman, DM Curran, JE Cromack, DT Tripathy, D Blangero, J Duggirala, R Goring, HHH DeFronzo, RA Jenkinson, CP AF Winnier, Deidre A. Fourcaudot, Marcel Norton, Luke Abdul-Ghani, Muhammad A. Hu, Shirley L. Farook, Vidya S. Coletta, Dawn K. Kumar, Satish Puppala, Sobha Chittoor, Geetha Dyer, Thomas D. Arya, Rector Carless, Melanie Lehman, Donna M. Curran, Joanne E. Cromack, Douglas T. Tripathy, Devjit Blangero, John Duggirala, Ravindranath Goering, Harald H. H. DeFronzo, Ralph A. Jenkinson, Christopher P. TI Transcriptomic Identification of ADH1B as a Novel Candidate Gene for Obesity and Insulin Resistance in Human Adipose Tissue in Mexican Americans from the Veterans Administration Genetic Epidemiology Study (VAGES) SO PLOS ONE LA English DT Article ID TYPE-2 DIABETES-MELLITUS; HUMAN SKELETAL-MUSCLE; GENOME-WIDE ASSOCIATION; ETHANOL-PRODUCTION; GLUCOSE-TOLERANCE; LINKAGE ANALYSIS; NONALCOHOLIC STEATOHEPATITIS; ADIPOGENIC DIFFERENTIATION; ALCOHOL-DEHYDROGENASE; FAMILY-HISTORY AB Type 2 diabetes (T2D) is a complex metabolic disease that is more prevalent in ethnic groups such as Mexican Americans, and is strongly associated with the risk factors obesity and insulin resistance. The goal of this study was to perform whole genome gene expression profiling in adipose tissue to detect common patterns of gene regulation associated with obesity and insulin resistance. We used phenotypic and genotypic data from 308 Mexican American participants from the Veterans Administration Genetic Epidemiology Study (VAGES). Basal fasting RNA was extracted from adipose tissue biopsies from a subset of 75 unrelated individuals, and gene expression data generated on the Illumina BeadArray platform. The number of gene probes with significant expression above baseline was approximately 31,000. We performed multiple regression analysis of all probes with 15 metabolic traits. Adipose tissue had 3,012 genes significantly associated with the traits of interest (false discovery rate, FDR <= 0.05). The significance of gene expression changes was used to select 52 genes with significant (FDR <= 10(-4)) gene expression changes across multiple traits. Gene sets/Pathways analysis identified one gene, alcohol dehydrogenase 1B (ADH1B) that was significantly enriched (P < 10(-60)) as a prime candidate for involvement in multiple relevant metabolic pathways. Illumina BeadChip derived ADH1B expression data was consistent with quantitative real time PCR data. We observed significant inverse correlations with waist circumference (2.8 x 10(-9)), BMI (5.4 x 10(-6)), and fasting plasma insulin (P < 0.001). These findings are consistent with a central role for ADH1B in obesity and insulin resistance and provide evidence for a novel genetic regulatory mechanism for human metabolic diseases related to these traits. C1 [Winnier, Deidre A.; Fourcaudot, Marcel; Norton, Luke; Abdul-Ghani, Muhammad A.; Tripathy, Devjit; DeFronzo, Ralph A.; Jenkinson, Christopher P.] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, Div Diabet, San Antonio, TX 78229 USA. [Hu, Shirley L.] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, Div Nephrol, San Antonio, TX 78229 USA. [Farook, Vidya S.; Kumar, Satish; Puppala, Sobha; Chittoor, Geetha; Dyer, Thomas D.; Carless, Melanie; Curran, Joanne E.; Blangero, John; Duggirala, Ravindranath; Goering, Harald H. H.; Jenkinson, Christopher P.] Texas Biomed Res Inst, San Antonio, TX USA. [Cromack, Douglas T.] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, Div Orthoped, San Antonio, TX 78229 USA. [Arya, Rector] Univ Texas Hlth Sci Ctr San Antonio, Dept Pediat, Div Endocrinol & Diabet, San Antonio, TX 78229 USA. [Lehman, Donna M.] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, Div Clin Epidemiol, San Antonio, TX 78229 USA. [Cromack, Douglas T.; Tripathy, Devjit; DeFronzo, Ralph A.; Jenkinson, Christopher P.] South Texas Vet Hlth Care Syst, San Antonio, TX USA. [Coletta, Dawn K.] Arizona State Univ, Sch Life Sci, Tempe, AZ USA. RP Jenkinson, CP (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Med, Div Diabet, San Antonio, TX 78229 USA. EM jenkinsonc@uthscsa.edu RI Coletta, Dawn/G-6382-2016 OI Coletta, Dawn/0000-0001-5819-5152; Norton, Luke/0000-0002-0231-5722 FU Veterans Administration: Merit Review Award [11487646]; Genetic Epidemiologic Grant; National Institutes of Health [DK79195, DK067690, DK53889, HD41111, DK70746, MH59490] FX This study was supported in part by grants from the Veterans Administration: Merit Review Award 11487646 (CPJ) and Genetic Epidemiologic Grant (RAD) and the National Institutes of Health: DK79195 (CPJ), DK067690 (CPJ), DK53889 (RD), HD41111 (RD), DK70746 (DML) and MH59490 (JB). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 68 TC 3 Z9 3 U1 0 U2 9 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 1 PY 2015 VL 10 IS 4 AR e0119941 DI 10.1371/journal.pone.0119941 PG 26 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CE9AM UT WOS:000352135600017 PM 25830378 ER PT J AU Slatore, CG Au, DH Press, N Wiener, RS Golden, SE Ganzini, L AF Slatore, Christopher G. Au, David H. Press, Nancy Wiener, Renda Soylemez Golden, Sara E. Ganzini, Linda TI Decision making among Veterans with incidental pulmonary nodules: A qualitative analysis SO RESPIRATORY MEDICINE LA English DT Article DE Pulmonary nodule; Lung cancer; Shared decision making ID LUNG-CANCER; HEALTH-CARE; RADIATION-EXPOSURE; FLEISCHNER-SOCIETY; CLINICAL-PRACTICE; GUIDELINES; STATEMENT; MANAGEMENT; MODEL; SCANS AB Purpose: Among patients undergoing lung cancer evaluation for newly diagnosed, incidental pulmonary nodules, it is important to evaluate the shared power and responsibility domain of patient-centered communication. We explored Veterans' perceptions of decision making with regards to an incidentally-detected pulmonary nodule. Methods: We conducted semi-structured, qualitative interviews of 19 Veterans from one medical center with incidentally-detected pulmonary nodules that were judged as having a low risk for malignancy. We used qualitative description for the analysis, focusing on patients' perceptions of shared decision making with their primary care provider (PCP). Interviews were conducted in 2011 and 2012. Results: Patients almost always played a passive role in deciding how and when to evaluate their pulmonary nodule for the possibility of malignancy. Some patients felt comfortable with this role, expressing trust that their clinician would provide the appropriate care. Other patients were not satisfied with how these decisions were made with some expressing concern that no decisions had actually occurred. Regardless of how satisfied they were with the decision, patients did not report discussing how they liked to make decisions with their PCP. Conclusions: Veterans in our study did not engage in shared decision making with their clinician. Some were satisfied with this approach although many would have preferred a shared approach. In order to reduce patient distress and improve satisfaction, clinicians may want to consider adopting a shared approach when making decisions about pulmonary nodule evaluation. Published by Elsevier Ltd. C1 [Slatore, Christopher G.; Golden, Sara E.; Ganzini, Linda] Portland VA Med Ctr, Hlth Serv Res Dev, Portland, OR USA. [Slatore, Christopher G.] Portland VA Med Ctr, Sect Pulm & Crit Care Med, Portland, OR USA. [Slatore, Christopher G.] Oregon Hlth & Sci Univ, Dept Med, Div Pulm & Crit Care Med, Portland, OR 97201 USA. [Au, David H.] VA Puget Sound Hlth Care Syst, Hlth Serv Res & Dev, Seattle, WA USA. [Au, David H.] Univ Washington, Sch Med, Div Pulm & Crit Care Med, Seattle, WA USA. [Press, Nancy] Oregon Hlth & Sci Univ, Sch Nursing, Portland, OR 97201 USA. [Wiener, Renda Soylemez] Edith Nourse Rogers Mem VA Hosp, Ctr Hlth Qual Outcomes & Econ Res, Bedford, MA USA. [Wiener, Renda Soylemez] Boston Univ, Sch Med, Ctr Pulm, Boston, MA 02118 USA. RP Slatore, CG (reprint author), 3710 SW US Vet Hosp Rd R&D 66, Portland, OR 97239 USA. EM christopher.slatore@va.gov OI Wiener, Renda/0000-0001-7712-2135; Slatore, Christopher/0000-0003-0958-8122 FU VA HSRD [CDP 11-227] FX This study was sponsored by a VA HSRD Career Development Award (CDP 11-227) to Dr. Slatore. It was also supported by resources from the Portland VA Medical Center, Portland, Oregon, the Puget Sound VA Healthcare System, Seattle, WA and the Edith Nourse Rogers Memorial VA Hospital, Bedford, Massachusetts. The Department of Veterans Affairs did not have a role in the conduct of the study, in the collection, management, analysis, interpretation of data, or in the preparation of the manuscript. NR 47 TC 2 Z9 2 U1 1 U2 3 PU W B SAUNDERS CO LTD PI LONDON PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND SN 0954-6111 EI 1532-3064 J9 RESP MED JI Respir. Med. PD APR PY 2015 VL 109 IS 4 BP 532 EP 539 DI 10.1016/j.rmed.2015.01.007 PG 8 WC Cardiac & Cardiovascular Systems; Respiratory System SC Cardiovascular System & Cardiology; Respiratory System GA CE9PW UT WOS:000352176900013 PM 25660437 ER PT J AU Salmon, AB Lerner, C Ikeno, Y Perrine, SMM McCarter, R Sell, C AF Salmon, Adam B. Lerner, Chad Ikeno, Yuji Perrine, Susan M. Motch McCarter, Roger Sell, Christian TI Altered metabolism and resistance to obesity in long-lived mice producing reduced levels of IGF-I SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM LA English DT Article DE insulin-like growth factor I; insulin; metabolism; obesity; gluconeogenesis ID GROWTH-FACTOR-I; DIET-INDUCED OBESITY; HIGH-FAT DIET; HEPATIC INSULIN-RESISTANCE; PROTEIN-1 TRANSGENIC MICE; EXTENDS LIFE-SPAN; ISLET-CELL GROWTH; ADIPOSE-TISSUE; GLUCOSE-INTOLERANCE; A DEFICIENCY AB The extension of lifespan due to reduced insulin-like growth factor 1 (IGF-I) signaling in mice has been proposed to be mediated through alterations in metabolism. Previously, we showed that mice homozygous for an insertion in the Igf1 allele have reduced levels of IGF-I, are smaller, and have an extension of maximum lifespan. Here, we tested whether this specific reduction of IGF-I alters glucose metabolism both on normal rodent chow and in response to high-fat feeding. We found that female IGF-I-deficient mice were lean on a standard rodent diet but paradoxically displayed an insulin-resistant phenotype. However, these mice gained significantly less weight than normal controls when placed on a high-fat diet. In control animals, insulin response was significantly impaired by high-fat feeding, whereas IGF-I-deficient mice showed a much smaller shift in insulin response after high-fat feeding. Gluconeogenesis was also elevated in the IGF-I-deficient mice relative to controls on both normal and high-fat diet. An analysis of metabolism and respiratory quotient over 24 h indicated that the IGF-I-deficient mice preferentially utilized fatty acids as an energy source when placed on a high-fat diet. These results indicate that reduction in the circulating and tissue IGF-I levels can produce a metabolic phenotype in female mice that increases peripheral insulin resistance but renders animals resistant to the deleterious effects of high-fat feeding. C1 [Salmon, Adam B.; Ikeno, Yuji] Univ Texas Hlth Sci Ctr San Antonio, Sam & Ann Barshop Inst Longev & Aging Studies, San Antonio, TX 78229 USA. [Salmon, Adam B.] Univ Texas Hlth Sci Ctr San Antonio, Dept Mol Med, San Antonio, TX 78229 USA. [Ikeno, Yuji] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, San Antonio, TX 78229 USA. [Salmon, Adam B.; Ikeno, Yuji] Audie L Murphy Vet Affairs Hosp, South Texas Vet Hlth Care Syst, Geriatr Res Educ & Clin Ctr, San Antonio, TX USA. [Lerner, Chad; Sell, Christian] Drexel Univ, Coll Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA. [Perrine, Susan M. Motch] Penn State Univ, Dept Anthropol, University Pk, PA 16802 USA. [McCarter, Roger] Penn State Univ, Ctr Dev & Hlth Genet, University Pk, PA 16802 USA. RP Salmon, AB (reprint author), Univ Texas Hlth Sci, 15355 Lambda Dr, San Antonio, TX 78245 USA. EM salmona@uthscsa.edu OI Salmon, Adam/0000-0002-1475-7843 FU National Institutes of Health Training Grant [T32-AG021890-05]; National Institute on Aging [AG-223343]; Drexel University Aging Initiative [AG-02243]; Geriatric Research, Education, and Clinical Center of the South Texas Health Care System; American Federation of Aging Research FX This work was supported by National Institutes of Health Training Grant T32-AG021890-05, Grant No. AG-223343 from the National Institute on Aging, funds from the Drexel University Aging Initiative, and Grant No. AG-02243 to C. Sell. A. B. Salmon was supported by the the Geriatric Research, Education, and Clinical Center of the South Texas Health Care System and a grant from the American Federation of Aging Research. NR 51 TC 3 Z9 3 U1 0 U2 3 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0193-1849 EI 1522-1555 J9 AM J PHYSIOL-ENDOC M JI Am. J. Physiol.-Endocrinol. Metab. PD APR 1 PY 2015 VL 308 IS 7 BP E545 EP E553 DI 10.1152/ajpendo.00558.2014 PG 9 WC Endocrinology & Metabolism; Physiology SC Endocrinology & Metabolism; Physiology GA CE9WO UT WOS:000352194300001 PM 25648834 ER PT J AU Katz, M Luciano, MS Carlson, K Luo, P Marks, WJ Larson, PS Starr, PA Follett, KA Weaver, FM Stern, MB Reda, DJ Ostrem, JL AF Katz, Maya Luciano, Marta San Carlson, Kimberly Luo, Ping Marks, William J., Jr. Larson, Paul S. Starr, Philip A. Follett, Kenneth A. Weaver, Frances M. Stern, Matthew B. Reda, Domenic J. Ostrem, Jill L. CA CSP 468 Study Grp TI Differential Effects of Deep Brain Stimulation Target on Motor Subtypes in Parkinson's Disease SO ANNALS OF NEUROLOGY LA English DT Article ID SUBTHALAMIC NUCLEUS STIMULATION; RANDOMIZED CONTROLLED-TRIAL; PALLIDAL STIMULATION; MEDICAL THERAPY; OUTCOMES; TREMOR; METAANALYSIS; MULTICENTER; DOPAMINE; PD AB ObjectiveThe Veterans Administration Cooperative Studies Program #468, a multicenter study that randomized Parkinson's disease (PD) patients to either subthalamic nucleus (STN) or globus pallidus internus (GPi) deep brain stimulation (DBS), found that stimulation at either target provided similar overall motoric benefits. We conducted an additional analysis of this data set to evaluate whether PD motor subtypes responded differently to the 2 stimulation targets. MethodsWe classified 235 subjects by motor subtype: tremor dominant (TD), intermediate (I), or postural instability gait difficulty (PIGD), based on pre-DBS baseline Unified Parkinson's Disease Rating Scale (UPDRS) scores off-medication. The primary outcome was change in UPDRS part III (UPDRS-III) off-medication scores from baseline to 24 months post-DBS, compared among subjects with particular PD motor subtypes and by DBS target (STN vs GPi). Changes in tremor, rigidity, akinesia, and gait scores were also assessed using the UPDRS. ResultsTD patients had greater mean overall motor improvement, measured by UPDRS-III, after GPi DBS, compared to STN DBS (17.513.0 vs 14.6 +/- 14.9, p=0.02), with improvement in gait accounting for this difference. Regardless of stimulation target, PIGD subjects had lower mean overall improvement in UPDRS-III scores compared with I or TD subjects (8.7 +/- 12.2 vs 21.7 +/- 11.2 vs 16.3 +/- 13.8, p=0.001). InterpretationOur results suggest that responsiveness to both GPi and STN DBS is similar among different PD motor subtypes, although the TD motor subtype may have a greater response to GPi DBS with respect to gait. PIGD patients obtained less overall benefit from stimulation. Ann Neurol 2015;77:710-719 C1 [Katz, Maya; Luciano, Marta San; Marks, William J., Jr.; Ostrem, Jill L.] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94131 USA. [Katz, Maya; Luciano, Marta San; Marks, William J., Jr.; Ostrem, Jill L.] San Francisco VA Med Ctr, Parkinsons Dis Res Educ & Clin Ctr, San Francisco, CA USA. [Carlson, Kimberly; Reda, Domenic J.] Dept Vet Affairs, Off Res & Dev, Cooperat Studies Program, Washington, DC USA. [Luo, Ping] Domen Reda & Kimberly Carlson Hines VA Cooperat S, Hines, IL USA. [Larson, Paul S.; Starr, Philip A.] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94131 USA. [Follett, Kenneth A.] Univ Nebraska Med Ctr, Dept Neurosurg, Omaha, NE USA. [Weaver, Frances M.] Edward J Hines Jr VA Hosp, Ctr Innovat Complex Chron Healthcare, Hines, IL USA. [Weaver, Frances M.] Loyola Univ, Stritch Sch Med, Maywood, IL 60153 USA. [Stern, Matthew B.] Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USA. RP Katz, M (reprint author), Univ Calif San Francisco, 1635 Divisadero St,Suite 520, San Francisco, CA 94131 USA. EM maya.katz@ucsfmedctr.org FU Cooperative Studies Program of the Department of Veterans Affairs Office of Research and Development; NIH National Institute of Neurological Disorders and Stroke; Medtronic FX The CSP #468 study was supported by the Cooperative Studies Program of the Department of Veterans Affairs Office of Research and Development, the NIH National Institute of Neurological Disorders and Stroke, and Medtronic. Our additional analysis of the original study received no specific funding support. NR 36 TC 6 Z9 6 U1 1 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0364-5134 EI 1531-8249 J9 ANN NEUROL JI Ann. Neurol. PD APR PY 2015 VL 77 IS 4 BP 710 EP 719 DI 10.1002/ana.24374 PG 10 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA CE8OK UT WOS:000352102500015 PM 25627340 ER PT J AU Singh, JA AF Singh, Jasvinder A. TI When gout goes to the heart: does gout equal a cardiovascular disease risk factor? SO ANNALS OF THE RHEUMATIC DISEASES LA English DT Editorial Material ID EVIDENCE BASED RECOMMENDATIONS; PERIPHERAL ARTERIAL-DISEASE; ACUTE MYOCARDIAL-INFARCTION; URIC-ACID LEVEL; RHEUMATOID-ARTHRITIS; INDEPENDENT IMPACT; TASK-FORCE; MORTALITY; HYPERURICEMIA; METAANALYSIS C1 [Singh, Jasvinder A.] Birmingham VA Med Ctr, Med Serv, Birmingham, AL USA. [Singh, Jasvinder A.] Univ Alabama Birmingham, Div Epidemiol, Birmingham, AL 35294 USA. [Singh, Jasvinder A.] Univ Alabama Birmingham, Med, Birmingham, AL 35294 USA. [Singh, Jasvinder A.] Mayo Clin, Coll Med, Dept Orthoped Surg, Rochester, MN USA. RP Singh, JA (reprint author), Univ Alabama Birmingham, Fac Off Tower 805B,510 20th St S, Birmingham, AL 35294 USA. EM Jasvinder.md@gmail.com NR 28 TC 4 Z9 4 U1 0 U2 0 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0003-4967 EI 1468-2060 J9 ANN RHEUM DIS JI Ann. Rheum. Dis. PD APR PY 2015 VL 74 IS 4 BP 631 EP 634 DI 10.1136/annrheumdis-2014-206432 PG 4 WC Rheumatology SC Rheumatology GA CE2AV UT WOS:000351615700003 PM 25603830 ER PT J AU Mahindra, A Raval, G Mehta, P Brazauskas, R Zhang, MJ Zhong, XB Bird, JM Freytes, CO Hale, GA Herzig, R Holmberg, LA Kamble, RT Kumar, S Lazarus, HM Majhail, NS Marks, DI Moreb, JS Olsson, R Saber, W Savani, BN Schiller, GJ Tay, J Vogl, DT Waller, EK Wiernik, PH Wirk, B Lonial, S Krishnan, AY Dispenzieri, A Brandenburg, NA Gale, RP Hari, PN AF Mahindra, Anuj Raval, Girindra Mehta, Paulette Brazauskas, Ruta Zhang, Mei-Jie Zhong, Xiaobo Bird, Jennifer M. Freytes, Cesar O. Hale, Gregory A. Herzig, Roger Holmberg, Leona A. Kamble, Rammurti T. Kumar, Shaji Lazarus, Hillard M. Majhail, Navneet S. Marks, David I. Moreb, Jan S. Olsson, Richard Saber, Wael Savani, Bipin N. Schiller, Gary J. Tay, Jason Vogl, Dan T. Waller, Edmund K. Wiernik, Peter H. Wirk, Baldeep Lonial, Sagar Krishnan, Amrita Y. Dispenzieri, Angela Brandenburg, Nancy A. Gale, Robert Peter Hari, Parameswaran N. TI New Cancers after Autotransplantations for Multiple Myeloma SO BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION LA English DT Article DE Myeloma; Second cancer; Transplantation ID STEM-CELL TRANSPLANTATION; 2ND PRIMARY MALIGNANCIES; MYELODYSPLASTIC SYNDROMES; ACUTE-LEUKEMIA; LENALIDOMIDE; THERAPY; NEOPLASMS; RISK; CHEMOTHERAPY; METAANALYSIS AB We describe baseline incidence and risk factors for new cancers in 4161 persons receiving autotransplants for multiple myeloma in the United States from 1990 to 2010. Observed incidence of invasive new cancers was compared with expected incidence relative to the US population. The cohort represented 13,387 person-years at-risk. In total, 163 new cancers were observed, for a crude incidence rate of 1.2 new cancers per 100 person-years and cumulative incidences of 2.6% (95% confidence interval [CI], 2.09 to 3.17), 4.2% (95% Cl, 3.49 to 5.00), and 6.1% (95% CI, 5.08 to 7.24) at 3, 5, and 7 years, respectively. The incidence of new cancers in the autotransplantation cohort was similar to age-, race-, and gender-adjusted comparison subjects with an observed/expected (O/E) ratio of 1.00 (99% CI, .81 to 1.22). However, acute myeloid leukemia and melanoma were observed at higher than expected rates with 0/E ratios of 5.19 (99% CI, 1.67 to 12.04; P = .0004), and 3.58 (99% CI, 1.82 to 6.29; P < .0001), respectively. Obesity, older age, and male gender were associated with increased risks of new cancers in multivariate analyses. This large data set provides a baseline for comparison and defines the histologic type specific risk for new cancers in patients with MM receiving post-autotransplantation therapies, such as maintenance. (C) 2015 American Society for Blood and Marrow Transplantation. C1 [Mahindra, Anuj] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Raval, Girindra] Jefferson Reg Med Ctr, Pine Bluff, AR USA. [Mehta, Paulette] Univ Arkansas Med Sci, Little Rock, AR 72205 USA. [Mehta, Paulette] Cent Arkansas Vet Healthcare Syst, Little Rock, AR USA. [Brazauskas, Ruta; Zhang, Mei-Jie; Zhong, Xiaobo; Saber, Wael] Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Dept Med, Milwaukee, WI 53226 USA. [Brazauskas, Ruta; Zhang, Mei-Jie] Med Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI 53226 USA. [Bird, Jennifer M.; Marks, David I.] Univ Hosp Bristol NHS Trust, Bristol, Avon, England. [Freytes, Cesar O.] South Texas Vet Hlth Care Syst, San Antonio, TX USA. [Freytes, Cesar O.] Univ Texas Hlth Sci, Ctr San Antonio, San Antonio, TX USA. [Hale, Gregory A.] All Childrens Hosp, St Petersburg, FL USA. [Herzig, Roger] Univ Louisville Hosp, James Brown Canc Ctr, Louisville, KY USA. [Holmberg, Leona A.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Kamble, Rammurti T.] Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA. [Kumar, Shaji; Dispenzieri, Angela] Mayo Clin, Rochester, MN USA. [Lazarus, Hillard M.] Univ Hosp, Case Med Ctr, Seidman Canc Ctr, Cleveland, OH USA. [Majhail, Navneet S.] Cleveland Clin, Cleveland, OH 44106 USA. [Moreb, Jan S.] Shands HealthCare, Gainesville, FL USA. [Moreb, Jan S.] Univ Florida, Gainesville, FL USA. [Olsson, Richard] Karolinska Inst, Dept Lab Med, Div Therapeut Immunol, Stockholm, Sweden. [Olsson, Richard] Uppsala Univ, Ctr Clin Res Sormland, Uppsala, Sweden. [Savani, Bipin N.] Vanderbilt Univ, Med Ctr, Nashville, TN 37235 USA. [Schiller, Gary J.] Univ Calif Los Angeles, Ctr Hlth Sci, Nashville, TN USA. [Tay, Jason] Univ Ottawa, Ottawa, ON, Canada. Univ Penn, Abramson Canc Ctr, Med Ctr, Philadelphia, PA 19104 USA. [Waller, Edmund K.; Lonial, Sagar] Emory Univ Hosp, Winship Canc Inst, Atlanta, GA 30322 USA. [Wiernik, Peter H.] Our Lady Mercy Med Ctr, Bronx, NY USA. [Wirk, Baldeep] SUNY Stony Brook, Med Ctr, Stony Brook, NY 11794 USA. [Krishnan, Amrita Y.] City Hope Natl Med Ctr, Duarte, CA 91010 USA. [Brandenburg, Nancy A.] Celgene Corp, Summit, NJ USA. [Gale, Robert Peter] Univ London Imperial Coll Sci Technol & Med, London, England. RP Hari, PN (reprint author), Ctr Int Blood & Marrow Transplant Res, Med colIege Wisconsin, Div Hematol & Oncol, 9200W Wisconsin Ave,Suite C5500, Milwaukee, WI 53226 USA. EM phari@mcw.edu OI Olsson, Richard/0000-0001-5970-2128; Dispenzieri, Angela/0000-0001-8780-9512; Hari, Parameswaran/0000-0002-8800-297X FU Public Health Service Grant from the National Cancer Institute [U24-CA076518]; National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases; NHLBI [5U10HL069294]; NCI; Health Resources and Services Administration [HHSH250201200016C]; Office of Naval Research [N00014-12-1-0142, N00014-13-1-0039]; Actinium Pharmaceuticals; Allos Therapeutics, Inc.; Amgen; Be The Match Foundation; Blue Cross and Blue Shield Association; Celgene Corporation; Chimerix, Inc.; Fred Hutchinson Cancer Research Center; Fresenius-Biotech North America, Inc.; Gamida Cell Teva Joint Venture Ltd.; Genentech, Inc.; Gentium SpA; Genzyme Corporation; GlaxoSmithKline; Health Research, Inc.; Roswell Park Cancer Institute; HistoGenetics; Incyte Corporation; Jeff Gordon Children's Foundation; Kiadis Pharma; Leukemia & Lymphoma Society; Medac GmbH; Medical College of Wisconsin; Merck Co., Inc.; Millennium: The Takeda Oncology Co.; Milliman USA, Inc.; Miltenyi Biotec; National Marrow Donor Program; Onyx Pharmaceuticals; Optum Healthcare Solutions, Inc.; Osiris Therapeutics; Otsuka America Pharmaceutical, Inc.; Perkin Elmer, Inc.; Remedy Informatics; Sanofi US; Seattle Genetics; Sigma-Tau Pharmaceuticals; Soligenix, Inc.; St. Baldrick's Foundation; StemCyte; Global Cord Blood Therapeutics Co.; Stemsoft Software, Inc.; Swedish Orphan Biovitrum; Tarix Pharmaceuticals; Terumo BCT; Teva Neuroscience, Inc.; Therakos; University of Minnesota; University of Utah; WellPoint FX The CIBMTR is supported by Public Health Service Grant/Cooperative Agreement U24-CA076518 from the National Cancer Institute, the National Heart, Lung, and Blood Institute and the National Institute of Allergy and Infectious Diseases; a grant/cooperative agreement 5U10HL069294 from NHLBI and NCI; a contract HHSH250201200016C with Health Resources and Services Administration; 2 grants N00014-12-1-0142 and N00014-13-1-0039 from the Office of Naval Research; and grants from Actinium Pharmaceuticals; Allos Therapeutics, Inc.; Amgen; anonymous donation to the Medical College of Wisconsin; Ariad; Be The Match Foundation; Blue Cross and Blue Shield Association; Celgene Corporation; Chimerix, Inc.; Fred Hutchinson Cancer Research Center; Fresenius-Biotech North America, Inc.; Gamida Cell Teva Joint Venture Ltd.; Genentech, Inc.; Gentium SpA; Genzyme Corporation; GlaxoSmithKline; Health Research, Inc.; Roswell Park Cancer Institute; HistoGenetics; Incyte Corporation; Jeff Gordon Children's Foundation; Kiadis Pharma; The Leukemia & Lymphoma Society; Medac GmbH; The Medical College of Wisconsin; Merck & Co., Inc.; Millennium: The Takeda Oncology Co.; Milliman USA, Inc.; Miltenyi Biotec; National Marrow Donor Program; Onyx Pharmaceuticals; Optum Healthcare Solutions, Inc.; Osiris Therapeutics; Otsuka America Pharmaceutical, Inc.; Perkin Elmer, Inc.; Remedy Informatics; Sanofi US; Seattle Genetics; Sigma-Tau Pharmaceuticals; Soligenix, Inc.; St. Baldrick's Foundation; StemCyte, A Global Cord Blood Therapeutics Co.; Stemsoft Software, Inc.; Swedish Orphan Biovitrum; Tarix Pharmaceuticals; Terumo BCT; Teva Neuroscience, Inc.; Therakos; University of Minnesota; University of Utah; and WellPoint The views expressed in this article do not reflect the official policy or position of the National Institute of Health, the Department of the Navy, the Department of Defense, Health Resources and Services Administration or any other agency of the US Government. Additional support for this study was provided by Celgene Corporation. NR 28 TC 5 Z9 5 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1083-8791 EI 1523-6536 J9 BIOL BLOOD MARROW TR JI Biol. Blood Marrow Transplant. PD APR PY 2015 VL 21 IS 4 BP 738 EP 745 DI 10.1016/j.bbmt.2014.12.028 PG 8 WC Hematology; Immunology; Transplantation SC Hematology; Immunology; Transplantation GA CE4GY UT WOS:000351790300024 PM 25555448 ER PT J AU Jana, P Maiti, S Kahn, NN Sinha, AK AF Jana, Pradipta Maiti, Smarajit Kahn, Nighat N. Sinha, Asru K. TI Estriol-induced fibrinolysis due to the activation of plasminogen to plasmin by nitric oxide synthesis in platelets SO BLOOD COAGULATION & FIBRINOLYSIS LA English DT Article DE human serum albumin precursor; nongenomic expression of the estriol effect; plasmin; plasminogen activation ID HUMAN-BLOOD-PLATELETS; THROMBOLYSIS; PURIFICATION; STIMULATION; ENDOTHELIUM; THROMBOSIS; SYNTHASE; ESTROGEN; RECEPTOR; KINETICS AB Estriol, an oestrogen, at 0.6 nmol/l was reported to inhibit ADP-induced platelet aggregation through nitric oxide synthesis. As nitric oxide has been reported to cause fibrinolysis due to the activation of plasminogen to plasmin, the role of estriol as a fibrinolytic agent was investigated. Also, the mechanism of estriol-induced nitric oxide synthesis in anucleated platelets was investigated. The estriol-induced lysis of platelet-rich plasma (PRP) clot was determined by photography of the clot lysis and by the assay of fibrin degradation products in the lysate and was obtained by SDS-PAGE. Nitric oxide was determined by methemoglobin method. The platelet membrane protein was isolated from the platelets by using Triton X-100 (0.05% v/v). The binding of estriol to the protein was determined by Scatchard plot by using an ELISA for estriol. Estriol at 0.6 nmol/l was found to lyse the clotted PRP due to fibrinolysis that produced fibrin degradation products in the lysate. The amino acid analysis of the platelet membrane protein, which resembles with nitric oxide synthase (NOS) activity, was activated nearly 10-fold over the control in the presence of estriol and was identified to be a human serum albumin precursor (Mr. 69 kDa) that binds to estriol with Kd(1) of 6.0x10(-9) mol/l and 39 +/- 2 molecules of estriol bound the NOS molecule. The estriol-induced nitric oxide is capable of inducing fibrinolysis of the clotted PRP. The binding of estriol to platelet membrane NOS activated the enzyme in the absence of DNA in the platelet. Blood Coagul Fibrinolysis 26: 316-323 Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved. C1 [Jana, Pradipta; Sinha, Asru K.] Sinha Inst Med Sci & Technol, Kolkata, India. [Jana, Pradipta; Maiti, Smarajit] Vidyasagar Univ, Oriental Inst Sci & Technol, Cell & Mol Therapeut Lab, Post Grad Dept Biochem & Biotechnol, Medinipur, W Bengal, India. [Kahn, Nighat N.] James J Peters VA Med Ctr, Bronx, NY USA. RP Sinha, AK (reprint author), Sinha Inst Med Sci & Technol, 288 Kendua Main Rd, Kolkata 700084, W Bengal, India. EM asruksinha@yahoo.com NR 32 TC 1 Z9 1 U1 2 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0957-5235 EI 1473-5733 J9 BLOOD COAGUL FIBRIN JI Blood Coagul. Fibrinolysis PD APR PY 2015 VL 26 IS 3 BP 316 EP 323 DI 10.1097/MBC.0000000000000085 PG 8 WC Hematology SC Hematology GA CE5PQ UT WOS:000351888000015 PM 24695088 ER PT J AU Hirata, H Hinoda, Y Shahryari, V Deng, GR Nakajima, K Tabatabai, ZL Ishii, N Dahiya, R AF Hirata, Hiroshi Hinoda, Yuji Shahryari, Varahram Deng, Guoren Nakajima, Koichi Tabatabai, Z. Laura Ishii, Nobuhisa Dahiya, Rajvir TI Long Noncoding RNA MALAT1 Promotes Aggressive Renal Cell Carcinoma through Ezh2 and Interacts with miR-205 SO CANCER RESEARCH LA English DT Article ID BLADDER-CANCER METASTASIS; KIDNEY CANCER; TUMOR-SUPPRESSOR; UP-REGULATION; TRANSCRIPTION; EXPRESSION; HOTAIR; REGION; CERNA; EPIMUTATION AB Recently, long noncoding RNAs (lncRNA) have emerged as new gene regulators and prognostic markers in several cancers, including renal cell carcinoma (RCC). In this study, we investigated the contributions of the lncRNA MALAT1 in RCC with a specific focus on its transcriptional regulation and its interactions with Ezh2 and miR-205. We found that MALAT1 expression was higher in human RCC tissues, where it was associated with reduced patient survival. MALAT1 silencing decreased RCC cell proliferation and invasion and increased apoptosis. Mechanistic investigations showed that MALAT1 was transcriptionally activated by c-Fos and that it interacted with Ezh2. After MALAT1 silencing, E-cadherin expression was increased, whereas beta-catenin expression was decreased through Ezh2. Reciprocal interaction between MALAT1 and miR-205 was also observed. Lastly, MALAT1 bound Ezh2 and oncogenesis facilitated by MALAT1 was inhibited by Ezh2 depletion, thereby blocking epithelial-mesenchymal transition via E-cadherin recovery and beta-catenin downregulation. Overall, our findings illuminate how overexpression of MALAT1 confers an oncogenic function in RCC that may offer a novel theranostic marker in this disease. (C)2015 AACR. C1 [Hirata, Hiroshi; Shahryari, Varahram; Deng, Guoren; Dahiya, Rajvir] San Francisco VA Med Ctr, Dept Urol, San Francisco, CA 94121 USA. [Hirata, Hiroshi; Shahryari, Varahram; Deng, Guoren; Tabatabai, Z. Laura; Dahiya, Rajvir] Univ Calif San Francisco, San Francisco, CA 94121 USA. [Hinoda, Yuji] Yamaguchi Univ, Grad Sch Med, Dept Oncol & Lab Med, Yamaguchi, Japan. [Nakajima, Koichi; Ishii, Nobuhisa] Toho Univ, Fac Med, Dept Urol, Tokyo, Japan. [Tabatabai, Z. Laura] San Francisco VA Med Ctr, Dept Pathol, San Francisco, CA 94121 USA. RP Dahiya, R (reprint author), San Francisco VA Med Ctr, 4150 Clement St, San Francisco, CA 94121 USA. EM rdahiya@urology.ucsf.edu FU National Center for Research Resources of the National Institutes of Health [RO1CA130860, RO1CA138642, RO1CA160079, 101BX001123]; VA Merit Review; VA Program Project; Yamada Science Foundation FX This study was supported by National Center for Research Resources of the National Institutes of Health through grant numbers RO1CA130860, RO1CA138642, RO1CA160079, and 101BX001123, VA Merit Review, VA Program Project (Principal Investigator, R. Dahiya), and Yamada Science Foundation. NR 48 TC 91 Z9 98 U1 5 U2 27 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD APR 1 PY 2015 VL 75 IS 7 BP 1322 EP 1331 DI 10.1158/0008-5472.CAN-14-2931 PG 10 WC Oncology SC Oncology GA CE6LW UT WOS:000351948900019 PM 25600645 ER PT J AU Kim, JY Kim, N Yenari, MA AF Kim, Jong-Youl Kim, Nuri Yenari, Midori A. TI Mechanisms and Potential Therapeutic Applications of Microglial Activation after Brain Injury SO CNS NEUROSCIENCE & THERAPEUTICS LA English DT Review DE Brain injury; Inflammation; Microglia; Neurotoxic mediator ID FOCAL CEREBRAL-ISCHEMIA; NITRIC-OXIDE SYNTHASE; CENTRAL-NERVOUS-SYSTEM; TUMOR-NECROSIS-FACTOR; NF-KAPPA-B; MICROGLIA/MACROPHAGE POLARIZATION DYNAMICS; INTRACEREBRAL INFLAMMATORY RESPONSE; RECEPTOR-GAMMA AGONISTS; CELL-ADHESION MOLECULES; TRANSGENIC MOUSE MODEL AB As the resident immune cells of the central nervous system, microglia rapidly respond to brain insults, including stroke and traumatic brain injury. Microglial activation plays a major role in neuronal cell damage and death by releasing a variety of inflammatory and neurotoxic mediators. Their activation is an early response that may exacerbate brain injury and many other stressors, especially in the acute stages, but are also essential to brain recovery and repair. The full range of microglial activities is still not completely understood, but there is accumulating knowledge about their role following brain injury. We review recent progress related to the deleterious and beneficial effects of microglia in the setting of acute neurological insults and the current literature surrounding pharmacological interventions for intervention. C1 [Kim, Jong-Youl; Kim, Nuri; Yenari, Midori A.] Univ Calif San Francisco, Dept Neurol, San Francisco Vet Affairs Med Ctr, San Francisco, CA 94121 USA. RP Yenari, MA (reprint author), Univ Calif San Francisco, Dept Neurol, San Francisco Vet Affairs Med Ctr, 4150 Clement,MS 127, San Francisco, CA 94121 USA. EM yenari@alum.mit.edu FU National Institutes of Health (NIH) [NS40516]; Veteran's Merit Awards; American Hearts Association [13POST14810019]; Veterans Affairs Medical Center, San Francisco, California FX This work was supported by grants from the National Institutes of Health (NIH) (NS40516 to MY), the Veteran's Merit Awards to MY, and American Hearts Association (13POST14810019) to JYK. Grants to MY and JYK were administered by the Northern California Institute for Research and Education and supported by resources of the Veterans Affairs Medical Center, San Francisco, California. NR 217 TC 11 Z9 11 U1 0 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1755-5930 EI 1755-5949 J9 CNS NEUROSCI THER JI CNS Neurosci. Ther. PD APR PY 2015 VL 21 IS 4 SI SI BP 309 EP 319 DI 10.1111/cns.12360 PG 11 WC Neurosciences; Pharmacology & Pharmacy SC Neurosciences & Neurology; Pharmacology & Pharmacy GA CE5JX UT WOS:000351870400003 PM 25475659 ER PT J AU Hershenberg, R Olino, TM Dyson, MW Davila, J Kleine, DN AF Hershenberg, Rachel Olino, Thomas M. Dyson, Margaret W. Davila, Joanne Kleine, Daniel N. TI Are personality disorder dimensions related over time? An examination over the course of ten years using multivariate growth modeling SO COMPREHENSIVE PSYCHIATRY LA English DT Article ID 5-FACTOR MODEL; PATTERNS; COOCCURRENCE; COMORBIDITY; OUTPATIENTS; STABILITY AB Objective: Despite the well-documented literature on cross-sectional comorbidity, there is a paucity of data on the associations between personality disorders (PDs) over time. Using multivariate growth modeling, the present study examined the inter-relationships between pairs of PD disorder dimensions. Methods: We tested these associations in a sample of 142 depressed outpatients followed-up five times over the course of 10 years. Results: We found cross-sectional associations between the initial levels of severity of many pairs of PD dimensions. However, there was limited support for longitudinal associations between PD dimensions. Conclusion: These findings suggest that the course of PD dimensions is fairly independent of each other, and that initial levels of PD dimensions have relatively little prognostic value for predicting the course of other PD dimensions. Published by Elsevier Inc. C1 [Hershenberg, Rachel] Philadelphia VA Med Ctr, VISN MIRECC 4, Philadelphia, PA 19104 USA. [Hershenberg, Rachel] Univ Penn, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA. [Olino, Thomas M.] Temple Univ, Dept Psychol, Philadelphia, PA 19122 USA. [Dyson, Margaret W.] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA. [Davila, Joanne; Kleine, Daniel N.] SUNY Stony Brook, Dept Psychol, Stony Brook, NY 11794 USA. RP Hershenberg, R (reprint author), Philadelphia VA Med Ctr, VISN MIRECC 4, 3900 Woodland Ave, Philadelphia, PA 19104 USA. EM rhersh@mail.med.upenn.edu; thomas.olino@temple.edu; mdyson@ucsd.edu; joanne.davila@stonybrook.edu; Daniel.klein@stonybrook.edu FU VISN 4 Mental Illness Research, Education, and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA; NIH [K01 MH09263, RO1 MH45757] FX This paper was prepared with the support of the VISN 4 Mental Illness Research, Education, and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA. The views expressed in the article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs or the United States government. Dr. Olino was supported by NIH grant K01 MH09263. Dr. Klein was supported by NIH grant RO1 MH45757. There were no conflicts of interest related to this project or its authors. NR 29 TC 0 Z9 0 U1 1 U2 5 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0010-440X EI 1532-8384 J9 COMPR PSYCHIAT JI Compr. Psychiat. PD APR PY 2015 VL 58 BP 11 EP 17 DI 10.1016/j.comppsych.2014.12.002 PG 7 WC Psychiatry SC Psychiatry GA CE4NR UT WOS:000351807800002 PM 25659664 ER PT J AU Tapp, A Wood, AE Kennedy, A Sylvers, P Kilzieh, N Saxon, AJ AF Tapp, Andre Wood, Amanda Ernst Kennedy, Annette Sylvers, Patrick Kilzieh, Nael Saxon, Andrew J. TI Quetiapine for the treatment of cocaine use disorder SO DRUG AND ALCOHOL DEPENDENCE LA English DT Article DE Cocaine use disorder; Quetiapine; Treatment trial ID PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND TRIAL; OPEN-LABEL TRIAL; DEPENDENT PATIENTS; TIMELINE FOLLOWBACK; ALCOHOL DEPENDENCE; BIPOLAR DISORDER; SUBSTANCE USE; PILOT TRIAL; RISPERIDONE AB Background: Cocaine addiction continues to be a significant healthcare issue, yet there are no FDA approved medications for the treatment of cocaine use disorder within the United States. Methods: This 12-week, prospective, double-blind, randomized, placebo-controlled study examined the effectiveness of quetiapine (Seroquel XR (TM)) versus matched placebo for the treatment of DSM-IV cocaine dependence in non-psychotic individuals. Subjects randomized to quetiapine (N = 29) were titrated up to a target dose of 400 mg/day of quetiapine, while those in the placebo arm (N = 31) were given a matched placebo. All subjects had weekly clinic visits and a cognitive-behavioral therapy group session. Outcome measures included self-report of cocaine use and money spent on cocaine as well as urine drug screens (UDS). Results: The drop-out rate was substantial at 68%. Logistic regression analysis did not find significant differences between groups in predicting end-of trial abstinence, defined as three consecutive weekly negative UDS (13.7% in the quetiapine group versus 12.9% in the placebo group; p = .92). Based upon a repeated measures analysis of variance, subjects in this study, as a whole, demonstrated reductions in their self-reported use of cocaine, self-reported money spent on cocaine, and number of days per week using cocaine. However, the quetiapine group did not differ significantly from the placebo group. Conclusions: This study did not find group differences between the quetiapine and placebo arms, suggesting that quetiapine is not an efficacious treatment for DSM-IV cocaine dependence. Published by Elsevier Ireland Ltd. C1 [Tapp, Andre] Univ Washington, Amer Lake Div A 116, VA Puget Sound Hlth Care Syst, Tacoma, WA 98493 USA. [Wood, Amanda Ernst; Sylvers, Patrick; Kilzieh, Nael; Saxon, Andrew J.] Univ Washington, VA Puget Sound Hlth Care Syst, Tacoma, WA 98493 USA. [Kennedy, Annette] Univ Wyoming, Sheridan VAMC, Laramie, WY 82071 USA. RP Tapp, A (reprint author), Univ Washington, Amer Lake Div A 116, VA Puget Sound Hlth Care Syst, 9600 Vet Dr SW, Tacoma, WA 98493 USA. EM Andre.Tapp@va.gov FU AstraZeneca Pharmaceuticals FX Funding for this study was provided by an investigator initiated grant from AstraZeneca Pharmaceuticals; AstraZeneca Pharmaceuticals had no role in study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication. NR 47 TC 3 Z9 3 U1 1 U2 8 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0376-8716 EI 1879-0046 J9 DRUG ALCOHOL DEPEN JI Drug Alcohol Depend. PD APR 1 PY 2015 VL 149 BP 18 EP 24 DI 10.1016/j.drugalcdep.2014.12.037 PG 7 WC Substance Abuse; Psychiatry SC Substance Abuse; Psychiatry GA CE4KJ UT WOS:000351799200003 PM 25682480 ER PT J AU Hoerster, KD Jakupcak, M Hanson, R McFall, M Reiber, G Hall, KS Nelson, KM AF Hoerster, Katherine D. Jakupcak, Matthew Hanson, Robert McFall, Miles Reiber, Gayle Hall, Katherine S. Nelson, Karin M. TI PTSD and depression symptoms are associated with binge eating among US Iraq and Afghanistan veterans SO EATING BEHAVIORS LA English DT Article DE Veterans; Post-traumatic stress disorder; Depression; Obesity; Binge eating ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH; OBESE VETERANS; CARE; OVERWEIGHT; MILITARY; BEHAVIOR AB Objective: US Iraq and Afghanistan Veterans with post-traumatic stress disorder (PTSD) and depression are at increased risk for obesity. Understanding the contribution of health behaviors to this relationship will enhance efforts to prevent and reduce obesity. Therefore, we examined the association of PTSD and depression symptoms with binge eating, a risk factor for obesity, among Iraq/Afghanistan Veterans. Method: Iraq/Afghanistan Veterans were assessed at intake to the VA Puget Sound Healthcare System-Seattle post-deployment clinic (May 2004-January 2007). The Patient Health Questionnaire was used to measure depression and binge eating symptoms, and the PTSD Checklist-Military Version assessed PTSD symptoms. Results: The majority of the sample (N = 332) was male (91.5%) and Caucasian (72.6%), with an average age of 31.1 (SD = 8.5) years; 16.3% met depression screening criteria, 37.8% met PTSD screening criteria, and 8.4% met binge eating screening criteria. In adjusted models, those meeting depression (odds ratio (OR) = 7.53; 95% CI = 2.69, 21.04; p < .001) and PTSD (OR = 3.37; 95% CI = 1.34, 8.46; p = .01) screening criteria were more likely to meet binge eating screening criteria. Continuous measures of PTSD and depression symptom severity were also associated with meeting binge eating screening criteria (ps < .05). Conclusion: PTSD and depression are common conditions among Iraq/Afghanistan Veterans. In the present study, PTSD and depression symptoms were associated with meeting binge eating screening criteria, identifying a possible pathway by which psychiatric conditions lead to disproportionate burden of overweight and obesity in this Veteran cohort. Tailored dietary behavior interventions may be needed for Iraq/Afghanistan Veterans with co-morbid obesity and psychiatric conditions. Published by Elsevier Ltd. C1 [Hoerster, Katherine D.; Jakupcak, Matthew; McFall, Miles] VA Puget Sound Healthcare Syst, Seattle Div, Mental Hlth Serv, Seattle, WA 98108 USA. [Hoerster, Katherine D.; Jakupcak, Matthew; McFall, Miles] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [Hanson, Robert; Reiber, Gayle; Nelson, Karin M.] VA Puget Sound Healthcare Syst, Res & Dev Serv, Seattle, WA 98108 USA. [Reiber, Gayle] Univ Washington, Sch Publ Hlth, Dept Hlth Serv, Seattle, WA 98195 USA. [Reiber, Gayle] Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA. [Hall, Katherine S.] Durham Vet Affairs Med Ctr, Geriatr Res Educ & Clin Ctr, Durham, NC 27705 USA. [Hall, Katherine S.] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA. [Nelson, Karin M.] VA Puget Sound Healthcare Syst, Gen Internal Med Serv, Seattle, WA 98108 USA. [Nelson, Karin M.] Univ Washington, Dept Med, Seattle, WA 98195 USA. RP Hoerster, KD (reprint author), 1660 S Columbian Way S-116, Seattle, WA 98108 USA. EM Katherine.Hoerster@va.gov; Matthew.Jakupcak@va.gov; Robert.Hanson@va.gov; Miles.McFall@va.gov; Gayle.Reiber@va.gov; katherine.hall@duke.edu; Karin.Nelson@va.gov FU Career Development Award from the Rehabilitation Research and Development Service of the Department of Veterans Affairs [2RX001316] FX There was no funding for this paper. This material is the result of work supported by resources from VA Puget Sound Healthcare System. Dr. Hall is funded by a Career Development Award from the Rehabilitation Research and Development Service of the Department of Veterans Affairs (2RX001316). The funders had no role in the study design, collection, analysis or interpretation of the data, writing the manuscript, or the decision to submit the paper for publication. NR 22 TC 7 Z9 7 U1 3 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1471-0153 EI 1873-7358 J9 EAT BEHAV JI Eat. Behav. PD APR PY 2015 VL 17 BP 115 EP 118 DI 10.1016/j.eatbeh.2015.01.005 PG 4 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA CE4XP UT WOS:000351834000025 PM 25687231 ER PT J AU Murray, RJ Debbane, M Fox, PT Bzdok, D Eickhoff, SB AF Murray, Ryan J. Debbane, Martin Fox, Peter T. Bzdok, Danilo Eickhoff, Simon B. TI Functional Connectivity Mapping of Regions Associated with Self- and Other-Processing SO HUMAN BRAIN MAPPING LA English DT Review DE self-concept; rostral anterior cingulate; social value; posterior cingulate; precuneus; social cognition; connectivity ID ANTERIOR CINGULATE CORTEX; COORDINATE-BASED METAANALYSIS; CORTICAL MIDLINE STRUCTURES; TEMPORO-PARIETAL JUNCTION; MEDIAL PREFRONTAL CORTEX; DEFAULT-MODE NETWORK; SOCIAL COGNITION; DECISION-MAKING; TEMPOROPARIETAL JUNCTION; HUMAN BRAIN AB Neuroscience literature increasingly suggests a conceptual self composed of interacting neural regions, rather than independent local activations, yet such claims have yet to be investigated. We, thus, combined task-dependent meta-analytic connectivity modeling (MACM) with task-independent resting-state (RS) connectivity analysis to delineate the neural network of the self, across both states. Given psychological evidence implicating the self's interdependence on social information, we also delineated the neural network underlying conceptual other-processing. To elucidate the relation between the self-/other-networks and their function, we mined the MACM metadata to generate a cognitive-behavioral profile for an empirically identified region specific to conceptual self, the pregenual anterior cingulate (pACC), and conceptual other, posterior cingulate/precuneus (PCC/PC). Mining of 7,200 published, task-dependent, neuroimaging studies, using healthy human subjects, yielded 193 studies activating the self-related seed and were conjoined with RS connectivity analysis to delineate a differentiated self-network composed of the pACC (seed) and anterior insula, relative to other functional connectivity. Additionally, 106 studies activating the other-related seed were conjoined with RS connectivity analysis to delineate a differentiated other-network of PCC/PC (seed) and angular gyrus/temporoparietal junction, relative to self-functional connectivity. The self-network seed related to emotional conflict resolution and motivational processing, whereas the other-network seed related to socially oriented processing and contextual information integration. Notably, our findings revealed shared RS connectivity between ensuing self-/other-networks within the ventromedial prefrontal cortex and medial orbitofrontal cortex, suggesting self-updating via integration of self-relevant social information. We, therefore, present initial neurobiological evidence corroborating the increasing claims of an intricate self-network, the architecture of which may promote social value processing. Hum Brain Mapp 36:1304-1324, 2015. (c) 2014 Wiley Periodicals, Inc. C1 [Murray, Ryan J.; Debbane, Martin] Univ Geneva, Fac Psychol & Educ Sci, Dev Clin Psychol Res Unit, Geneva, Switzerland. [Murray, Ryan J.] Univ Geneva, Swiss Ctr Affect Sci, Geneva, Switzerland. [Debbane, Martin] Univ Geneva, Geneva Fac Med, Dept Psychiat, Off Med Pedagog, Geneva, Switzerland. [Debbane, Martin] UCL, Res Dept Clin Educ & Hlth Psychol, London WC1E 6BT, England. [Fox, Peter T.] Univ Texas Hlth Sci Ctr San Antonio, Res Imaging Inst, San Antonio, TX 78229 USA. [Fox, Peter T.] South Texas Vet Hlth Care Syst, San Antonio, TX USA. [Bzdok, Danilo; Eickhoff, Simon B.] Res Ctr Julich, Inst Neurosci & Med INM 1, Julich, Germany. [Bzdok, Danilo; Eickhoff, Simon B.] Univ Dusseldorf, Inst Clin Neurosci & Med Psychol, Dusseldorf, Germany. RP Murray, RJ (reprint author), CISA Univ Geneva, Campus Biotech,Case Postale 60, CH-1211 Geneva 20, Switzerland. EM ryan.murray@unige.ch RI Eickhoff, Simon/K-2061-2013 OI Eickhoff, Simon/0000-0001-6363-2759 FU National Institute of Mental Health 907 [R01-MH074457]; Initiative and Networking Fund of the Helmholtz Association within the Helmholtz Alliance on Systems Biology (Human Brain Model); Swiss National Science Foundation [100014-135311/1] FX Contract grant sponsor: the National Institute of Mental Health 907; Contract grant number: R01-MH074457; Contract grant sponsor: the Initiative and Networking Fund of the Helmholtz Association within the Helmholtz Alliance on Systems Biology (Human Brain Model); Contract grant sponsor: the Swiss National Science Foundation; Contract grant number: 100014-135311/1 NR 151 TC 15 Z9 16 U1 5 U2 33 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1065-9471 EI 1097-0193 J9 HUM BRAIN MAPP JI Hum. Brain Mapp. PD APR PY 2015 VL 36 IS 4 BP 1304 EP 1324 DI 10.1002/hbm.22703 PG 21 WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA CE3OX UT WOS:000351737800006 PM 25482016 ER PT J AU Farkas, AH Vanderberg, R Sucato, GS Miller, E Akers, AY Borrero, S AF Farkas, Amy H. Vanderberg, Rachel Sucato, Gina S. Miller, Elizabeth Akers, Aletha Y. Borrero, Sonya TI Racial and Ethnic Differences in Young Men's Sex and Contraceptive Education SO JOURNAL OF ADOLESCENT HEALTH LA English DT Article DE Race; Disparities; Men; Sex education; Contraceptive education ID BEHAVIORS AB Purpose: Racial/ethnic disparities exist in young men's contraceptive knowledge. This study examines whether the likelihood of receiving sexual health education varies by race/ethnicity. Methods: We examined racial/ethnic differences in sex and contraceptive education both in school and from parents with multivariable logistic regression models among 4,104 men aged 15-24 years using data from the 2006-2010 National Survey of Family Growth. Results: Nearly all respondents (96.6%) reported formal sex education. Fewer reported formal birth control education (66.6%), parental sex discussions (66.8%), and parental discussions specifically about birth control (49.2%). In multivariable analysis, black men were less likely than white men to report receiving formal contraceptive education (adjusted odds ratio [aOR],.70; 95% CI, .51-.96). Both black and U.S.-born Hispanic men reported more parental sex discussions than white men (aOR, 1.44; 95% CI, 1.07-1.94, aOR, 1.47; 95% CI, 1.09-1.99, respectively). Conclusions: Nearly all respondents reported having received formal sexual health education. Fewer reported receiving education about birth control either at school or at home. Black men were less likely to report receiving formal contraceptive education. Published by Elsevier Inc. on behalf of Society for Adolescent Health and Medicine. C1 [Farkas, Amy H.; Vanderberg, Rachel; Borrero, Sonya] Univ Pittsburgh, Div Gen Internal Med, Dept Internal Med, Pittsburgh, PA 15213 USA. [Sucato, Gina S.; Miller, Elizabeth] UPMC, Childrens Hosp Pittsburgh, Dept Pediat, Div Adolescent Med, Pittsburgh, PA USA. [Akers, Aletha Y.] Childrens Hosp Philadelphia, Craig Dalsimer Div Adolescent Med, Gynecol Consultat Serv, Philadelphia, PA 19104 USA. [Borrero, Sonya] VA Pittsburgh Healthcare Syst, Ctr Hlth Equity Res & Promot, Pittsburgh, PA USA. RP Borrero, S (reprint author), Univ Pittsburgh, Ctr Res Hlth Care, 230 McKee Pl,Suite 600, Pittsburgh, PA 15213 USA. EM borrerosp@upmc.edu FU NIH [UL1-TR-000005] FX We thank Dan Winger, at the Clinical and Translation Science Institute, University of Pittsburgh supported by NIH grant UL1-TR-000005, for his assistance with statistical analysis. NR 9 TC 1 Z9 1 U1 1 U2 9 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1054-139X EI 1879-1972 J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD APR PY 2015 VL 56 IS 4 BP 464 EP 467 DI 10.1016/j.jadohealth.2014.12.014 PG 4 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA CE3BC UT WOS:000351698100018 PM 25797633 ER PT J AU Bunchorntavakul, C Jones, LM Kikuchi, M Valiga, ME Kaplan, DE Nunes, FA Aytaman, A Reddy, KR Chang, KM AF Bunchorntavakul, Chalermrat Jones, Lisa M. Kikuchi, Masahiro Valiga, Mary E. Kaplan, David E. Nunes, Frederick A. Aytaman, Ayse Reddy, K. Rajender Chang, Kyong-Mi TI Distinct Features in Natural History and Outcomes of Acute Hepatitis C SO JOURNAL OF CLINICAL GASTROENTEROLOGY LA English DT Article DE hepatitis C virus; acute hepatitis; RNA fluctuation; clinical presentation; autoantibody ID HIV-INFECTED MEN; INJECTION-DRUG USERS; T-CELL RESPONSES; VIRUS-INFECTION; FIBROSIS PROGRESSION; VIRAL CLEARANCE; LIVER FIBROSIS; UNITED-STATES; RISK-FACTORS; COHORT AB Background: Acute hepatitis C (AHCV) provides a diagnostic challenge with diverse clinical presentations. Goals: This study was aimed to examine the clinical and demographic features as well as outcomes in AHCV patients identified from inpatient and outpatient hospital settings. Study: Patients with suspected AHCV were recruited from Philadelphia VA Medical Center, Hospital of University of Pennsylvania and Brooklyn VA Medical Center between 2000 and 2010. AHCV was diagnosed by acute serum alanine aminotransferase elevation with anti-hepatitis C virus (HCV) sero-conversion, HCV-RNA fluctuations above 1 log, and/or recent high-risk exposure without prior HCV infection, excluding those with human immunodeficiency virus infection. Clinical and therapeutic outcomes were monitored for at least 6 months. Results: A total of 40 AHCV patients were enrolled with a median follow-up of 129 weeks. They were mostly men (68%) and whites (73%) with median age of 43 years, diverse risk factors (33% injection drugs, 20% health care-associated, 3% sexual, and 45% unknown), and wide variations in peak alanine aminotransferase (143 to 3435 U/L) and total bilirubin levels (0.4 to 19.3 mg/dL). Viremia resolved spontaneously in 23% and persisted without therapy in 27%, whereas 50% received interferon a-based therapy with 90% cure (18/20). Distinct clinical scenarios included: (1) wide viremic fluctuations > 1log (65%) and intermittent HCV-RNA negativity; (2) autoantibodies (25% antinuclear antibodies, 69% antismooth muscle antibodies) or autoimmune features; (3) delayed spontaneous viral clearance in 2 patients; (4) rapid cirrhosis progression in 2 patients. Conclusions: AHCV is a heterogenous disease that requires careful monitoring. The lack of apparent risk factor in high proportion of patients and its diverse presentations warrant diagnostic vigilance. C1 [Bunchorntavakul, Chalermrat; Jones, Lisa M.; Kikuchi, Masahiro; Valiga, Mary E.; Kaplan, David E.; Reddy, K. Rajender; Chang, Kyong-Mi] Univ Penn, Dept Med, Philadelphia, PA 19104 USA. [Jones, Lisa M.; Kikuchi, Masahiro; Valiga, Mary E.; Kaplan, David E.; Chang, Kyong-Mi] Philadelphia VA Med Ctr, Div Gastroenterol & Hepatol, Dept Med, Philadelphia, PA 19104 USA. [Nunes, Frederick A.] Penn Hosp, Philadelphia, PA 19107 USA. [Bunchorntavakul, Chalermrat] Rangsit Univ, Rajavithi Hosp, Coll Med, Bangkok, Thailand. [Aytaman, Ayse] VA New York Harbor Healthcare Syst, Brooklyn, NY USA. RP Chang, KM (reprint author), Philadelphia VA Med Ctr, A424,Med Res Bldg, Philadelphia, PA 19104 USA. EM kmchang@mail.med.upenn.edu FU Office of Research and Development, Department of Veterans Affairs [IOBX000649]; NIH [R01-AI-47519, R01-AA-12849, T32 DK 07066, K12-RR-017625]; Philadelphia VA Medical Research; NIH/NIDDK Center of Molecular Studies in Digestive and Liver Diseases [P30DK50306]; NIH Public Health Service Research [M01-RR00040]; NIH Loan Repayment Program; AASLD/Schering Advanced Hepatology Fellowship; VA Career Development Award; VA Stars and Stripes Award FX This material is based upon work supported in part by the Office of Research and Development, Department of Veterans Affairs with VA Merit Review IOBX000649 and with the resources and the use of facilities at the Philadelphia VA Medical Center. This study was also supported by NIH Grants R01-AI-47519 and R01-AA-12849; the Philadelphia VA Medical Research; NIH/NIDDK Center of Molecular Studies in Digestive and Liver Diseases P30DK50306 and its Molecular Biology and Cell Culture Core Facilities; the NIH Public Health Service Research Grant M01-RR00040. D.E.K. was supported by the NIH T32 DK 07066, NIH Loan Repayment Program, AASLD/Schering Advanced Hepatology Fellowship, NIH K12-RR-017625, and the VA Career Development Award and the VA Stars and Stripes Award. NR 53 TC 3 Z9 3 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0192-0790 EI 1539-2031 J9 J CLIN GASTROENTEROL JI J. Clin. Gastroenterol. PD APR PY 2015 VL 49 IS 4 BP E31 EP E40 PG 10 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA CE2GJ UT WOS:000351632400001 PM 24457946 ER PT J AU Marcus, DK Bell, EC Mercer, SH AF Marcus, David K. Bell, Erin C. Mercer, Sterett H. TI Adding Components Improves Treatment Outcomes: Reply to Fluckiger et al. (2015) SO JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY LA English DT Editorial Material DE specific ingredients; component studies; additive studies; psychotherapy research; sleeper effect ID DODO BIRD; METAANALYSIS AB In our article "Are the Parts as Good as the Whole? A Meta-Analysis of Component Treatment Studies" (Bell, Marcus, & Goodlad, 2013), we found that adding a component to an existing treatment resulted in better outcomes than the standard treatment for targeted problems at both termination and follow-up. The effect size at follow-up was twice as large as at termination, suggesting a "sleeper effect," but we did not test whether this increase was statistically significant. In their commentary on our article, Fluckiger, Del Re, and Wampold (2015) tested whether this difference was significant, and they found that it was not. The lack of support for a sleeper effect should not, however, distract from our central findings that specific ingredients can make a modest contribution to targeted treatment outcomes. The implications of these findings for the common factors versus specific ingredients debate are discussed. C1 [Marcus, David K.] Washington State Univ, Dept Psychol, Pullman, WA 99164 USA. [Bell, Erin C.] Med Univ S Carolina, Dept Psychiat & Behav Sci, Charleston, SC 29425 USA. [Bell, Erin C.] Ralph H Johnson Vet Affairs Med Ctr, Psychol Serv, Charleston, SC USA. [Mercer, Sterett H.] Univ British Columbia, Dept Educ & Counselling Psychol & Special Educ, Vancouver, BC V5Z 1M9, Canada. RP Marcus, DK (reprint author), Washington State Univ, Dept Psychol, Pullman, WA 99164 USA. EM david.marcus@wsu.edu NR 13 TC 1 Z9 1 U1 2 U2 5 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0022-006X EI 1939-2117 J9 J CONSULT CLIN PSYCH JI J. Consult. Clin. Psychol. PD APR PY 2015 VL 83 IS 2 BP 443 EP 444 DI 10.1037/ccp0000012 PG 2 WC Psychology, Clinical SC Psychology GA CE6KL UT WOS:000351945200020 ER PT J AU Huang, G Wharton, W Travison, TG Ho, MH Gleason, C Asthana, S Bhasin, S Basaria, S AF Huang, G. Wharton, W. Travison, T. G. Ho, M. H. Gleason, C. Asthana, S. Bhasin, S. Basaria, S. TI Effects of testosterone administration on cognitive function in hysterectomized women with low testosterone levels: a dose-response randomized trial SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION LA English DT Article DE Testosterone; Menopause; Cognition; Androgen deficiency ID HEALTH INITIATIVE MEMORY; POSTMENOPAUSAL WOMEN; SEX-HORMONES; REPLACEMENT THERAPY; SPATIAL COGNITION; MENSTRUAL-CYCLE; DOUBLE-BLIND; ESTROGEN; ABILITIES AB Purpose To determine the dose-dependent effects of testosterone administration on cognition in women with low testosterone levels. Methods 71 hysterectomized women with or without oophorectomy with total testosterone <31 ng/dl and/or free testosterone <3.5 pg/ml received a standardized transdermal estradiol regimen during the 12-week run-in period and were then randomized to receive weekly intramuscular injections of placebo, 3, 6.25, 12.5, or 25 mg testosterone enanthate for 24 weeks. Total testosterone was measured in serum by LC-MS/MS, and free testosterone levels were measured by equilibrium dialysis. Cognitive function was evaluated using a comprehensive battery of standardized neuropsychological tests at baseline and 24 weeks. Results 46 women who had baseline and end-of-treatment cognitive function data constituted the analytic sample. The five groups were similar at baseline. Mean on-treatment nadir total testosterone concentrations were 15, 89, 98, 134, and 234 ng/dl in the placebo, 3, 6.25, 12.5, and 25 mg groups, respectively. No significant changes in spatial ability, verbal fluency, verbal memory, or executive function were observed in any treatment arm compared to placebo even after adjustment for baseline cognitive function, age, and education. Multiple regression analysis did not show any significant relation between changes in testosterone concentrations and change in cognitive function scores. Conclusion Short-term testosterone administration over a wide range of doses for 24 weeks in women with low testosterone levels was neither associated with improvements nor worsening of cognitive function. C1 [Huang, G.; Travison, T. G.; Bhasin, S.; Basaria, S.] Harvard Univ, Brigham & Womens Hosp, Sect Mens Hlth Aging & Metab, Sch Med, Boston, MA 02115 USA. [Wharton, W.] Emory Univ, Dept Neurol, Atlanta, GA 30329 USA. [Ho, M. H.] Charles R Drew Univ Med & Sci, Div Endocrinol Metab & Mol Med, Los Angeles, CA 90059 USA. [Gleason, C.; Asthana, S.] Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI 53792 USA. [Gleason, C.; Asthana, S.] William S Middleton Mem Vet Adm Med Ctr, Geriatr Res Educ & Clin Ctr, Madison, WI 53705 USA. [Gleason, C.; Asthana, S.] Wisconsin Alzheimers Dis Res Ctr, Madison, WI 53792 USA. RP Huang, G (reprint author), Harvard Univ, Brigham & Womens Hosp, Sect Mens Hlth Aging & Metab, Sch Med, BLI-5,221 Longwood Ave, Boston, MA 02115 USA. EM ghuang7@partners.org FU National Institute of Child Health and Human Development [2008 TF D2274G]; Boston Claude D. Pepper Older Americans Independence Center Grant from the National Institute of Aging [5P30AG031679] FX This study was supported by Grants 5U54HD041748-04 (to Charles Drew University of Medicine and Science) and 2008 TF D2274G (sub award to Boston University) from the National Institute of Child Health and Human Development and the Boston Claude D. Pepper Older Americans Independence Center Grant #5P30AG031679 from the National Institute of Aging. Watson Pharmaceuticals provided the transdermal estradiol patch for this trial. ENDO Pharmaceuticals provided testosterone injections for this trial. NR 23 TC 1 Z9 1 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1720-8386 J9 J ENDOCRINOL INVEST JI J. Endocrinol. Invest. PD APR PY 2015 VL 38 IS 4 BP 455 EP 461 DI 10.1007/s40618-014-0213-3 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA CE3CQ UT WOS:000351702500010 PM 25430996 ER PT J AU Rich, JD Allen, SA Williams, BA AF Rich, Josiah D. Allen, Scott A. Williams, Brie A. TI The Need for Higher Standards in Correctional Healthcare to Improve Public Health SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Article ID CRIMINAL-JUSTICE SYSTEM; HEPATITIS-C; HIGH-RISK; EPIDEMIC; INMATES; INCARCERATION; FACILITIES; RELEASE; AGENDA; PRISON C1 [Rich, Josiah D.] Brown Univ, Warren Alpert Med Sch, Providence, RI 02912 USA. [Rich, Josiah D.; Allen, Scott A.] Miriam Hosp, Ctr Prisoner Hlth & Human Rights, Providence, RI 02906 USA. [Allen, Scott A.] Univ Calif Riverside, Sch Med, Riverside, CA 92521 USA. [Williams, Brie A.] Univ Calif San Francisco, Dept Med, Div Geriatr, San Francisco, CA USA. [Williams, Brie A.] San Francisco VA Med Ctr, San Francisco, CA USA. RP Rich, JD (reprint author), Miriam Hosp, Ctr Prisoner Hlth & Human Rights, 164 Summit Ave, Providence, RI 02906 USA. EM jrich@lifespan.org FU National Institute on Drug Abuse [K24DA022112]; National Institute on Allergy and Infectious Diseases [P30A142853]; National Institute on Aging [K23AG033102]; Jacob & Valeria Langeloth Foundation; UCSF Program for the Aging Century; UCSF Claude D. Pepper Older Americans Independence Center FX Dr. Rich is supported by the National Institute on Drug Abuse (K24DA022112) and the National Institute on Allergy and Infectious Diseases (P30A142853). Dr. Williams is an employee of the Department of Veterans Affairs and is supported by the National Institute on Aging (K23AG033102), The Jacob & Valeria Langeloth Foundation, the UCSF Program for the Aging Century, and the UCSF Claude D. Pepper Older Americans Independence Center. Dr. Rich participated in a single meeting of the Gilead advisory board in 2012 and is a stockholder in Alkermes. Drs. Rich, Allen, and Williams have all offered expert testimony in cases (12 cumulatively) involving the health care of prisoners. The opinions expressed in this manuscript may not represent those of the supporting agencies. NR 32 TC 1 Z9 1 U1 4 U2 12 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 IS 4 BP 503 EP 507 DI 10.1007/s11606-014-3142-0 PG 5 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CE2RO UT WOS:000351664000030 PM 25523471 ER PT J AU Chiovaro, J AF Chiovaro, Joseph TI Capsule commentary on Turner, et al. Chronic opioid therapy urine drug testing in primary care: prevalence and predictors of aberrant results (vol 30, pg 241, 2015) SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Correction C1 Oregon Hlth & Sci Univ, Portland VA Med Ctr, Portland, OR 97201 USA. RP Chiovaro, J (reprint author), Oregon Hlth & Sci Univ, Portland VA Med Ctr, Portland, OR 97201 USA. EM jchiovaro@gmail.com NR 1 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 EI 1525-1497 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2015 VL 30 IS 4 BP 534 EP 534 DI 10.1007/s11606-015-3232-7 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CE2RO UT WOS:000351664000037 PM 25701048 ER PT J AU Yoo, EM Trinh, KR Tran, D Vasuthasawat, A Zhang, J Hoang, B Lichtenstein, A Morrison, SL AF Yoo, Esther M. Trinh, Kham R. Danh Tran Vasuthasawat, Alex Zhang, Juan Hoang, Bao Lichtenstein, Alan Morrison, Sherie L. TI Anti-CD138-Targeted Interferon Is a Potent Therapeutic Against Multiple Myeloma SO JOURNAL OF INTERFERON AND CYTOKINE RESEARCH LA English DT Article ID ALPHA-INDUCED APOPTOSIS; B-CELL LYMPHOMA; MAMMALIAN TARGET; ANTITUMOR ACTIVITIES; IFN-ALPHA; RAPAMYCIN; 3-KINASE; FUSION; LINES; EXPRESSION AB Multiple myeloma (MM), a plasma cell malignancy, is the second most prevalent hematologic malignancy in the US. Although much effort has been made trying to understand the etiology and the complexities of this disease with the hope of developing effective therapies, MM remains incurable at this time. Because of their antiproliferative and proapoptotic activities, interferons (IFNs) have been used to treat various malignancies, including MM. Although some success has been observed, the inherent toxicities of IFNs limit their efficacy. To address this problem, we produced anti-CD138 antibody fusion proteins containing either IFN alpha 2 or a mutant IFN alpha 2 (IFN alpha 2(YNS)) with the goal of targeting IFN to CD138-expressing cells, thereby achieving effective IFN concentrations at the site of the tumor in the absence of toxicity. The fusion proteins inhibited the proliferation and induced apoptosis of U266, ANBL-6, NCI-H929, and MM1-144 MM cell lines. The fusion proteins decreased the expression of IFN regulatory factor 4 (IRF4) in U266. In addition, the fusion proteins were effective against primary cells from MM patients, and treatment with fusion proteins prolonged survival in the U266 murine model of MM. These studies show that IFN alpha antibody fusion proteins can be effective novel therapeutics for the treatment of MM. C1 [Yoo, Esther M.; Trinh, Kham R.; Danh Tran; Vasuthasawat, Alex; Zhang, Juan; Morrison, Sherie L.] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA. [Zhang, Juan] China Pharmaceut Univ, State Key Lab Nat Med, Sch Life Sci & Technol, Nanjing, Jiangsu, Peoples R China. [Hoang, Bao; Lichtenstein, Alan] Greater Los Angeles Vet Adm Healthcare Ctr, Los Angeles, CA USA. [Hoang, Bao; Lichtenstein, Alan] Jonsson Comprehens Canc Ctr, Los Angeles, CA 90034 USA. [Hoang, Bao; Lichtenstein, Alan] Univ Calif Los Angeles, Div Hematol Oncol, Los Angeles, CA 90095 USA. [Morrison, Sherie L.] Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90095 USA. RP Morrison, SL (reprint author), Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, 247 BSRB 615 Charles E Young Dr East, Los Angeles, CA 90095 USA. EM sheriem@microbio.ucla.edu FU Senior Research Award; Dean Assink/Multiple Myeloma Research Foundation Senior Research Award; National Institutes of Health [2RO1CA111448, 1RO1CA132778, 1R21CA168491]; Multiple Myeloma Research Foundation; Veteran's Administration FX This work was supported by the Senior Research Award (S.L.M.), the Dean Assink/Multiple Myeloma Research Foundation Senior Research Award (S.L.M.), the National Institutes of Health (grants 2RO1CA111448, 1RO1CA132778 and 1R21CA168491 to A.L.), and grants from the Multiple Myeloma Research Foundation (A.L.), and the Veteran's Administration (A.L.). NR 34 TC 5 Z9 5 U1 1 U2 4 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1079-9907 EI 1557-7465 J9 J INTERF CYTOK RES JI J. Interferon Cytokine Res. PD APR 1 PY 2015 VL 35 IS 4 BP 281 EP 291 DI 10.1089/jir.2014.0125 PG 11 WC Biochemistry & Molecular Biology; Cell Biology; Immunology SC Biochemistry & Molecular Biology; Cell Biology; Immunology GA CF1PW UT WOS:000352321000006 PM 25353626 ER PT J AU Ko, F Isoda, F Mobbs, C AF Ko, Fred Isoda, Fumiko Mobbs, Charles TI Laparotomy in Mice Induces Blood Cell Expression of Inflammatory and Stress Genes SO JOURNAL OF INTERFERON AND CYTOKINE RESEARCH LA English DT Article ID MONOCYTE CHEMOATTRACTANT PROTEIN-1; MULTIPLE ORGAN FAILURE; OXIDATIVE STRESS; REACTIVE OXYGEN; SURGICAL TRAUMA; GLUTATHIONE DEPLETION; SIGNALING PATHWAYS; IMMUNE-RESPONSE; ONCOSTATIN-M; SURGERY AB Surgical trauma induces immune and stress responses although its effects on postsurgical inflammatory and stress gene expression remain poorly characterized. This study sought to improve current scientific knowledge by investigating the effects of laparotomy on mouse blood cell inflammatory and stress gene expression. Three-month-old male C57BL/6J mice were subjected to 2% isoflurane or 2% isoflurane with laparotomy and sacrificed 4 h postintervention. Blood was collected and blood cell expression of 158 genes central to inflammatory and stress responses was assayed using quantitative polymerase chain reaction arrays. Mice subjected to isoflurane with laparotomy, compared with mice receiving isoflurane alone, had >2-fold upregulation of genes in inflammation (Osm, IL1rn, IL1b, and Csf1), oxidative stress (Hmox1), heat shock (Hspa1b), growth arrest (Cdkn1a), and DNA repair (Ugt1a2). These genes demonstrated similar expression patterns by Pearson correlation and cluster analysis. Thus, laparotomy induces coordinated, postsurgical blood cell expression of unique inflammatory and stress genes whose roles in influencing surgical outcomes need further investigation. C1 [Ko, Fred; Mobbs, Charles] Icahn Sch Med Mt Sinai, Brookdale Dept Geriatr & Palliat Med, New York, NY 10029 USA. [Ko, Fred] James J Peters VA Med Ctr, GRECC, Bronx, NY USA. [Isoda, Fumiko; Mobbs, Charles] Icahn Sch Med Mt Sinai, Dept Neurosci, New York, NY 10029 USA. RP Ko, F (reprint author), Icahn Sch Med Mt Sinai, Brookdale Dept Geriatr & Palliat Med, One Gustave L Levy Pl,Box 1070, New York, NY 10029 USA. EM fred.ko@mssm.edu FU NIH [P30 AG028741-01A2, 5KL2RR029885-03]; Hartford Foundation National Center of Excellence Award FX This work was supported by grants from the NIH (P30 AG028741-01A2 and 5KL2RR029885-03) and The Hartford Foundation National Center of Excellence Award. The authors wish to thank Dr. Christopher Cardozo's critical reading of this article and Qingling Du's assistance with statistical analysis. NR 58 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1079-9907 EI 1557-7465 J9 J INTERF CYTOK RES JI J. Interferon Cytokine Res. PD APR 1 PY 2015 VL 35 IS 4 BP 302 EP 312 DI 10.1089/jir.2014.0031 PG 11 WC Biochemistry & Molecular Biology; Cell Biology; Immunology SC Biochemistry & Molecular Biology; Cell Biology; Immunology GA CF1PW UT WOS:000352321000008 PM 25406893 ER PT J AU Linnemann, AK Battiola, TJ Kimple, ME Davis, DB Neuman, JC Davis, DB AF Linnemann, A. K. Battiola, T. J. Kimple, M. E. Davis, D. B. Neuman, J. C. Davis, D. B. TI PANCREATIC ISLET GLP-1 SECRETION IS INCREASED IN NON-DIABETIC OBESITY AND GLP-1 DIRECTLY REGULATES BETA-CELL CHOLECYSTOKININ PRODUCTION SO JOURNAL OF INVESTIGATIVE MEDICINE LA English DT Meeting Abstract CT Combined Annual Meeting of the Central-Society-for-Clinical-and-Translational-Research and Midwestern-Section of American-Federation-for-Medical-Research CY APR 23-24, 2015 CL Chicago, IL SP Cent Soc Clin & Translat Res, Amer Federat Med Res, Midwestern Sect C1 [Linnemann, A. K.; Battiola, T. J.; Kimple, M. E.; Davis, D. B.] Univ Wisconsin, Med Endocrinol, Madison, WI USA. [Neuman, J. C.] Univ Wisconsin, Nutr Sci, Madison, WI USA. [Davis, D. B.] William S Middleton Mem Vet Adm Med Ctr, Madison, WI USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1081-5589 EI 1708-8267 J9 J INVEST MED JI J. Invest. Med. PD APR PY 2015 VL 63 IS 4 MA 26 BP 667 EP 667 PG 1 WC Medicine, General & Internal; Medicine, Research & Experimental SC General & Internal Medicine; Research & Experimental Medicine GA CE3EZ UT WOS:000351710300048 ER PT J AU Perez, SE He, B Nadeem, M Wuu, J Ginsberg, SD Ikonomovic, MD Mufson, EJ AF Perez, Sylvia E. He, Bin Nadeem, Muhammad Wuu, Joanne Ginsberg, Stephen D. Ikonomovic, Milos D. Mufson, Elliott J. TI Hippocampal Endosomal, Lysosomal, and Autophagic Dysregulation in Mild Cognitive Impairment: Correlation With A beta and Tau Pathology SO JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY LA English DT Article DE Alzheimer disease; Autophagy; Cathepsin D; Endosomallysosomal proteins; Hippocampus; Mild cognitive impairment; mTOR; Rabaptin5 ID AMYLOID PRECURSOR PROTEIN; FRONTOTEMPORAL LOBAR DEGENERATION; SPORADIC ALZHEIMERS-DISEASE; CATHEPSIN-D; UP-REGULATION; ENDOCYTIC PATHWAY; SIGNALING PATHWAY; MAMMALIAN TARGET; NEURODEGENERATIVE DISEASES; NEUROTROPHIN RECEPTOR AB Endosomal-lysosomal and autophagic dysregulation occurs in the hippocampus in prodromal Alzheimer disease (AD), but its relationship with A-amyloid (AA) and tau pathology remains unclear. To investigate this issue, we performed immunoblot analysis of hippocampal homogenates from cases with an antemortem clinical diagnosis of no cognitive impairment, mild cognitive impairment (MCI), and AD. Western blot analysis revealed significant increases in the acid hydrolase cathepsin D and early endosome marker rabaptin5 in the MCI group compared with AD, whereas levels of phosphorylated mammalian target of rapamycin proteins (pmTOR), total mammalian target of rapamycin (mTOR), p62, traf6, and LilrB2 were comparable across clinical groups. Hippocampal A beta 1 (40) and A beta(1) (42) concentrations and AT8-immunopositive neurofibrillary tangle density were not significantly different across the clinical groups. Greater cathepsin D expression was associated with global cognitive score and episodic memory score but not with mini mental state examination or advanced neuropathology criteria. These results indicate that alterations in hippocampal endosomal-lysosomal proteins in MCI are independent of tau or AA pathology. C1 [Perez, Sylvia E.; Mufson, Elliott J.] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA. [He, Bin; Nadeem, Muhammad; Mufson, Elliott J.] Barrow Neurol Inst, Alzheimers Dis Res Lab, Phoenix, AZ 85013 USA. [Wuu, Joanne] Univ Miami, Miller Sch Med, Dept Neurol, Miami, FL 33136 USA. [Ginsberg, Stephen D.] Nathan S Kline Inst Psychiat Res, Ctr Dementia Res, Orangeburg, NY USA. [Ginsberg, Stephen D.] NYU Langone Med Ctr, Dept Psychiat, New York, NY USA. [Ginsberg, Stephen D.] NYU Langone Med Ctr, Dept Physiol, New York, NY USA. [Ginsberg, Stephen D.] NYU Langone Med Ctr, Dept Neurosci, New York, NY USA. [Ikonomovic, Milos D.] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15260 USA. [Ikonomovic, Milos D.] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15260 USA. [Ikonomovic, Milos D.] VA Pittsburgh Healthcare Syst, Geriatr Res Educ & Clin Ctr, Pittsburgh, PA USA. RP Mufson, EJ (reprint author), Barrow Neurol Inst, Alzheimers Dis Res Lab, 350 W Thomas St, Phoenix, AZ 85013 USA. EM elliott.mufson@dignityhealth.org FU NIA [PO1AG14449, RO1AG043375, P30AG010161, RO1AG042210, PO1AG025204, PO1AG107617]; Alzheimer's Association; Brinson Foundation FX Supported by NIA Grants PO1AG14449, RO1AG043375, P30AG010161, RO1AG042210, PO1AG025204, PO1AG107617, Alzheimer's Association, and Brinson Foundation. NR 110 TC 10 Z9 12 U1 2 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0022-3069 J9 J NEUROPATH EXP NEUR JI J. Neuropathol. Exp. Neurol. PD APR PY 2015 VL 74 IS 4 BP 345 EP 358 PG 14 WC Clinical Neurology; Neurosciences; Pathology SC Neurosciences & Neurology; Pathology GA CE2UV UT WOS:000351676100005 PM 25756588 ER PT J AU Scanzello, CR Markova, DZ Chee, A Xiu, Y Adams, SL Anderson, G Zgonis, M Qin, L An, HS Zhang, YJ AF Scanzello, Carla R. Markova, Dessislava Z. Chee, Ana Xiu, Yan Adams, Sherrill L. Anderson, Greg Zgonis, Miltiadis Qin, Ling An, Howard S. Zhang, Yejia TI Fibronectin Splice Variation in Human Knee Cartilage, Meniscus and Synovial Membrane: Observations in Osteoarthritic Knee SO JOURNAL OF ORTHOPAEDIC RESEARCH LA English DT Article DE fibronectin; alternative splicing; cartilage; synovium; degeneration ID B-CONTAINING FIBRONECTIN; RHEUMATOID-ARTHRITIS; ARTICULAR-CARTILAGE; EXTRA-DOMAIN; MESSENGER-RNA; EIIIA SEGMENT; CELL-ADHESION; NERVE GROWTH; ED-A; EXPRESSION AB Fibronectin (FN) is a widely expressed molecule that can participate in development of osteoarthritis (OA) affecting cartilage, meniscus, and synovial membrane (SM). The alternatively spliced isoforms of FN in joint tissues other than cartilage have not been extensively studied previously. The present study compares FN splice variation in patients with varying degrees of osteoarthritic change. Joint tissues were collected from asymptomatic donors and patients undergoing arthroscopic procedures. Total RNA was amplified by PCR using primers flanking alternatively spliced Extra Domain A (EDA), Extra Domain B (EDB) and Variable (V) regions. EDB+, EDB- and EDA(-) and V+ variants were present in all joint tissues, while the EDA(+) variant was rarely detected. Expression levels of EDB+ and EDV+ variants were similar in cartilage, synovium, and meniscal tissues. Synovial expression of V+ FN in arthroscopy patients varied with degree of cartilage degeneration. Two V- isoforms, previously identified in cartilage, were also present in SM and meniscus. Fibronectin splicing in meniscus and SM bears striking resemblance to that of cartilage. Expression levels of synovial V+ FN varied with degree of cartilage degeneration. V+ FN should be investigated as a potential biomarker of disease stage or progression in larger populations. (c) 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:556-562, 2015. C1 [Scanzello, Carla R.] Univ Penn, Philadelphia Vet Affairs Med Ctr, Div Rheumatol, Perelman Sch Med, Philadelphia, PA 19104 USA. [Markova, Dessislava Z.; Anderson, Greg] Thomas Jefferson Univ, Dept Orthoped Surg, Philadelphia, PA 19107 USA. [Chee, Ana; An, Howard S.; Zhang, Yejia] Rush Univ, Dept Orthoped Surg, Med Ctr, Chicago, IL 60612 USA. [Adams, Sherrill L.] Univ Penn, Sch Dent Med, Dept Biochem, Philadelphia, PA 19104 USA. [Xiu, Yan; Zgonis, Miltiadis; Qin, Ling] Univ Penn, Perelman Sch Med, Dept Orthoped Surg, Philadelphia, PA 19104 USA. [Zhang, Yejia] Univ Penn, Perelman Sch Med, Philadelphia Vet Affairs Med Ctr, Philadelphia, PA 19104 USA. [Zhang, Yejia] Univ Penn, Perelman Sch Med, Dept Phys Med & Rehabil, Philadelphia, PA 19104 USA. RP Zhang, YJ (reprint author), Rush Univ, Dept Orthoped Surg, Med Ctr, Chicago, IL 60612 USA. EM yejia.zhang@uphs.upenn.edu FU National Institute of Child Health and Human Development [1K08 HD049598]; National Institute of Arthritis, Musculoskeletal and Skin Diseases [1K08 AR057859]; NIH [AR060991] FX Grant sponsor: National Institute of Child Health and Human Development; Grant number: 1K08 HD049598; Grant sponsor: National Institute of Arthritis, Musculoskeletal and Skin Diseases; Grant number: 1K08 AR057859; Grant sponsor: NIH; Grant number: AR060991. NR 38 TC 4 Z9 4 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0736-0266 EI 1554-527X J9 J ORTHOP RES JI J. Orthop. Res. PD APR PY 2015 VL 33 IS 4 BP 556 EP 562 DI 10.1002/jor.22787 PG 7 WC Orthopedics SC Orthopedics GA CE2YE UT WOS:000351687400016 PM 25410897 ER PT J AU Yawn, J Lawrence, LA Carroll, WW Mulligan, JK AF Yawn, James Lawrence, Lauren A. Carroll, William W. Mulligan, Jennifer K. TI Vitamin D for the treatment of respiratory diseases: Is it the end or just the beginning? SO JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY LA English DT Review DE Vitamin D; Sinusitis; Asthma; Rhinitis; Supplementation ID AIRWAY SMOOTH-MUSCLE; 25-HYDROXYVITAMIN D LEVELS; BRONCHIAL EPITHELIAL-CELLS; REGULATORY T-CELLS; ALLERGIC FUNGAL RHINOSINUSITIS; 1,25-DIHYDROXYVITAMIN D-3; DENDRITIC CELLS; IN-VITRO; D DEFICIENCY; D SUPPLEMENTATION AB A large number of human, animal and in vitro studies have suggested that vitamin D3 (VD3) plays a critical role in inflammatory airway diseases such as asthma, chronic rhinosinusitis, and allergic rhinitis. VD3 acts upon a broad range of immune cells involved in the pathogenesis of these diseases including T-cells, dendritic cells (DCs), macrophages, and B-cells. In addition, VD3 can also regulate the functions of a number of non-immune cells including epithelial cells, fibroblasts, and smooth muscle cells. Given that VD3 has known effects on the immune system, it seems logical that supplementation with VD3 would prove efficacious in the treatment of these three diseases. While many studies, most of which are observational, have suggested that VD3 deficiency is associated with more severe disease, VD3 supplementation trials in humans have resulted in varied outcomes in terms of efficacy. In this review article we will discuss the role of VD3 in these three commonly associated respiratory diseases. We will explore the literature describing associations of VD3 deficiency with patient outcomes, cells in the respiratory microenvironment susceptible to VD3 regulation, conflicting results of VD3 supplementation trials, and potential gaps in our knowledge that may be limiting the widespread use of VD3 for the treatment of respiratory diseases such asthma, chronic rhinosinusitis and allergic rhinitis. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Yawn, James; Lawrence, Lauren A.; Carroll, William W.; Mulligan, Jennifer K.] Med Univ S Carolina, Dept Otolaryngol Head & Neck Surg, Charleston, SC 29425 USA. [Mulligan, Jennifer K.] Med Univ S Carolina, Dept Pediat, Charleston, SC 29425 USA. [Mulligan, Jennifer K.] Ralph H Johnson VA Med Ctr, Charleston, SC USA. RP Mulligan, JK (reprint author), 135 Rutledge Ave,MSC 550, Charleston, SC 29425 USA. EM konopa@musc.edu FU American Academy of Otolaryngology - Head & Neck Surgery Foundation; Flight Attendant Medical Research Institute; Department of Veterans Affairs; W.K. Kellogg Foundation; National Institute of Health; American Society of Pediatric Otolaryngology FX Dr. Carroll has received grant funding from the American Academy of Otolaryngology - Head & Neck Surgery Foundation. Dr. Mulligan has received research grant funding from the Flight Attendant Medical Research Institute, Department of Veterans Affairs,W.K. Kellogg Foundation, National Institute of Health and the American Society of Pediatric Otolaryngology. NR 173 TC 9 Z9 9 U1 1 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0960-0760 J9 J STEROID BIOCHEM JI J. Steroid Biochem. Mol. Biol. PD APR PY 2015 VL 148 SI SI BP 326 EP 337 DI 10.1016/j.jsbmb.2015.01.017 PG 12 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism SC Biochemistry & Molecular Biology; Endocrinology & Metabolism GA CE4FJ UT WOS:000351786200049 PM 25625665 ER PT J AU Win, AZ AF Win, Aung Zaw TI Telehealth Can Bridge the Gap for Rural, Disabled, and Elderly Patients SO JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION LA English DT Editorial Material ID QUALITY-OF-LIFE; HEALTH-CARE; TELEMEDICINE; AMERICA; IMPACT; MODEL C1 San Francisco VA Med Ctr, San Francisco, CA 94121 USA. RP Win, AZ (reprint author), San Francisco VA Med Ctr, 4150 Clement St, San Francisco, CA 94121 USA. EM aungzwin@gmail.com NR 16 TC 3 Z9 3 U1 1 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1525-8610 EI 1538-9375 J9 J AM MED DIR ASSOC JI J. Am. Med. Dir. Assoc. PD APR 1 PY 2015 VL 16 IS 4 BP 268 EP 269 DI 10.1016/j.jamda.2015.01.077 PG 2 WC Geriatrics & Gerontology SC Geriatrics & Gerontology GA CE6KT UT WOS:000351946000002 PM 25687928 ER PT J AU Sourbeer, KN Howard, LE Moreira, DM Amarasekara, HS Chow, LD Cockrell, DC Hanyok, BT Pratson, CL Kane, CJ Terris, MK Aronson, WJ Cooperberg, MR Amling, CL Hernandez, RK Freedland, SJ AF Sourbeer, Katharine N. Howard, Lauren E. Moreira, Daniel M. Amarasekara, Hiruni S. Chow, Lydia D. Cockrell, Dillon C. Hanyok, Brian T. Pratson, Connor L. Kane, Christopher J. Terris, Martha K. Aronson, William J. Cooperberg, Matthew R. Amling, Christopher L. Hernandez, Rohini K. Freedland, Stephen J. TI Practice Patterns and Predictors of Followup Imaging after a Negative Bone Scan in Men with Castration Resistant Prostate Cancer: Results from the SEARCH Database SO JOURNAL OF UROLOGY LA English DT Article DE prostatic neoplasms; prostate specific antigen; radionuclide imaging; neoplasm metastasis; physician's practice patterns ID BIOCHEMICAL RECURRENCE; RADICAL PROSTATECTOMY; SURVIVAL; ANTIGEN; RISK AB Purpose: We investigated imaging practice patterns in men with nonmetastatic (M0) castration resistant prostate cancer. Materials and Methods: We analyzed data on 247 patients with documented M0 CRPC from the SEARCH database. Patients were selected regardless of primary treatment modality and all had a negative bone scan after a castration resistant prostate cancer diagnosis. Cox models were used to test associations of time to a second imaging test with several demographic and clinical factors. Results: During a median followup of 29.0 months (IQR 12.9-43.5) after a postcastration resistant prostate cancer bone scan was negative, 190 patients (77%) underwent a second imaging test. On univariable analysis patients with higher prostate specific antigen (HR 1.13, p = 0.016), shorter prostate specific antigen doubling time (HR 0.79, p < 0.001) and faster prostate specific antigen velocity (HR 1.01, p < 0.001) were more likely to undergo a second imaging test. Treatment center was also a significant predictor of a second imaging test (p - 0.010). No other factor was a significant predictor. Results were similar on multivariable analysis. It was estimated that approximately 20% of men with a prostate specific antigen doubling time of less than 3 months did not undergo an imaging test in the first year after a post-castration resistant prostate cancer negative bone scan. However, 50% of patients with prostate specific antigen doubling time 15 months or greater underwent a second imaging test in the first year. Conclusions: Clinicians use some known predictors of positive imaging tests to determine which patients with M0 castration resistant prostate cancer undergo a second imaging test. However, there may be under imaging in those at high risk and over imaging in those at low risk. Further studies are needed to identify risk factors for metastasis and form clear imaging guidelines in patients with M0 castration resistant prostate cancer. C1 [Sourbeer, Katharine N.; Howard, Lauren E.; Amarasekara, Hiruni S.; Chow, Lydia D.; Cockrell, Dillon C.; Hanyok, Brian T.; Pratson, Connor L.; Freedland, Stephen J.] Duke Univ, Sch Med, Durham Vet Affairs Med Ctr, Urol Sect, Durham, NC USA. [Sourbeer, Katharine N.; Howard, Lauren E.; Amarasekara, Hiruni S.; Chow, Lydia D.; Cockrell, Dillon C.; Hanyok, Brian T.; Pratson, Connor L.; Freedland, Stephen J.] Duke Univ, Sch Med, Div Urol, Duke Prostate Ctr,Dept Surg, Durham, NC USA. [Howard, Lauren E.] Duke Univ, Sch Med, Dept Biostat, Durham, NC USA. [Freedland, Stephen J.] Duke Univ, Sch Med, Dept Pathol, Durham, NC 27706 USA. [Moreira, Daniel M.] Mayo Clin, Dept Urol, Rochester, MN USA. [Kane, Christopher J.] Univ Calif San Diego Hlth Syst, Dept Urol, San Diego, CA USA. [Aronson, William J.] Vet Affairs Greater Los Angeles Healthcare Syst, Dept Surg, Urol Sect, Los Angeles, CA USA. [Aronson, William J.] Univ Calif Los Angeles, Sch Med, Dept Urol, Los Angeles, CA USA. [Cooperberg, Matthew R.] Univ Calif San Francisco, Dept Urol, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA USA. [Hernandez, Rohini K.] Amgen Inc, Ctr Observat Res, Thousand Oaks, CA 91320 USA. [Terris, Martha K.] Vet Affairs Med Ctr, Urol Sect, Augusta, GA USA. [Terris, Martha K.] Med Coll Georgia, Augusta, GA 30912 USA. [Amling, Christopher L.] Oregon Hlth & Sci Univ, Div Urol, Portland, OR USA. RP Freedland, SJ (reprint author), Cedars Sinai Med Ctr, Dept Surg, Div Urol, 8635 West 3rd,Suite 1070W, Los Angeles, CA 90048 USA. EM Stephen.freedland@cshs.org OI Terris, Martha/0000-0002-3843-7270 FU Amgen FX Supported by Amgen. NR 18 TC 4 Z9 4 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-5347 EI 1527-3792 J9 J UROLOGY JI J. Urol. PD APR PY 2015 VL 193 IS 4 BP 1232 EP 1238 DI 10.1016/j.juro.2014.11.014 PG 7 WC Urology & Nephrology SC Urology & Nephrology GA CE8OO UT WOS:000352102900028 PM 25463986 ER PT J AU Madigan, M Entabi, F Zuckerbraun, B Loughran, P Tzeng, E AF Madigan, Michael Entabi, Fateh Zuckerbraun, Brian Loughran, Patricia Tzeng, Edith TI Delayed inhaled carbon monoxide mediates the regression of established neointimal lesions SO JOURNAL OF VASCULAR SURGERY LA English DT Article ID BARE-METAL STENTS; INHIBITS INTIMAL HYPERPLASIA; SMOOTH-MUSCLE-CELLS; BALLOON ANGIOPLASTY; HEME OXYGENASE-1; ELUTING STENTS; NITRIC-OXIDE; VEIN GRAFTS; APOPTOSIS; AUTOPHAGY AB Objective: Intimal hyperplasia (IH) contributes to the failure of vascular interventions. While many investigational therapies inhibit the development of IH in animal models, few of these potential therapies can reverse established lesions. Inhaled carbon monoxide (CO) dramatically inhibits IH in both rats and pigs when given perioperatively. It also prevented the development of pulmonary arterial hypertension in rodents. Interestingly, CO could reverse pulmonary artery structural changes and right heart hemodynamic changes when administered after the establishment of pulmonary hypertension. Thus, we hypothesize that inhaled CO may mediate the regression of established neointimal lesions. Methods: Rats underwent carotid artery balloon angioplasty injury. Carotid arteries were collected at 2 and 4 weeks after injury for morphometric analysis of the neointima. Another group was treated with inhaled CO (250 parts per million) for 1 hour daily from week 2 until week 4. Additional rats were sacrificed 3 days after initiating CO treatment, and the carotid arteries were examined for apoptosis by terminal deoxynucleotidyl transferase dUTP nick end-labeling, proliferation by Ki67 staining, and autophagy by microtubule-associated protein light chain 3 I/II staining. Results: At 2 weeks following injury, sizable neointimal lesions had developed (intimal/media [0.92 +/- 0.22). By 4 weeks, lesion size remained stable (0.80 +/- 0.09). Delayed inhaled CO treatment greatly reduced neointimal lesion size vs the 2-and 4-week control mice (0.38 +/- 0.05; P < .05). Arteries from the CO-treated rats exhibited significantly reduced apoptosis compared with control vessels (3.18% +/- 1.94% vs 16.26% +/- 5.91%; P = .036). Proliferation was also dramatically reduced in the CO-treated animals (2.98 +/- 1.55 vs 10.37 +/- 2.80; P = .036). No difference in autophagy between control and CO-treated rats was detected. Conclusions: Delayed administration of inhaled CO reduced established neointimal lesion size. This effect was mediated by the antiproliferative effect of CO on medial and intimal smooth muscle cells without increases in arterial wall apoptosis or autophagy. Future studies will examine additional time points to determine if there is temporal variation in the rates of apoptosis and autophagy. C1 [Madigan, Michael; Entabi, Fateh; Zuckerbraun, Brian; Tzeng, Edith] Univ Pittsburgh, Dept Vet Affairs Med Ctr, Pittsburgh, PA 15213 USA. [Madigan, Michael; Entabi, Fateh; Tzeng, Edith] Univ Pittsburgh, Div Vasc Surg, Pittsburgh, PA 15213 USA. [Zuckerbraun, Brian] Univ Pittsburgh, Dept Surg, Pittsburgh, PA 15213 USA. [Loughran, Patricia] Univ Pittsburgh, Ctr Biol Imaging, Pittsburgh, PA 15213 USA. RP Tzeng, E (reprint author), Univ Pittsburgh, VA Pittsburgh Healthcare Syst, Vasc Surg, A1010 PUH,200 Lothrop St, Pittsburgh, PA 15213 USA. EM tzenge@upmc.edu FU Department of Veterans Affairs, Veterans Health Administration [BX000635]; Office of Biomedical Laboratory Research and Development; NIH [T32 HL098036] FX This material is based upon work supported in part by the Department of Veterans Affairs, Veterans Health Administration (VA Merit Grant BX000635), Office of Biomedical Laboratory Research and Development (E.T.), and through funding from NIH T32 HL098036 (E.T.). NR 35 TC 3 Z9 3 U1 1 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD APR PY 2015 VL 61 IS 4 BP 1026 EP 1033 DI 10.1016/j.jvs.2013.11.072 PG 8 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA CE4BP UT WOS:000351776100029 PM 24418641 ER PT J AU Lynch, CP Baker, N Korte, JE Mauldin, JG Mayorga, ME Hunt, KJ AF Lynch, Cheryl P. Baker, Nathaniel Korte, Jeffrey E. Mauldin, Jill G. Mayorga, Maria E. Hunt, Kelly J. TI Increasing Prevalence of Diabetes During Pregnancy in South Carolina SO JOURNAL OF WOMENS HEALTH LA English DT Article ID OF-THE-LITERATURE; RISK-FACTORS; MELLITUS; WOMEN; POPULATION; METAANALYSIS; PREDICTORS; COHORT; TRENDS; US AB Background: The objective of our study was to examine the prevalence of diabetes during pregnancy at the population level in SC from January 1996 through December 2008. Methods: The study included 387,720 non-Hispanic white (NHW), 232,278 non-Hispanic black (NHB), and 43,454 Hispanic live singleton births. Maternal inpatient hospital discharge codes from delivery (91.59%) and prenatal information (i.e., Medicaid [42.91%] and SC State Health Plan [SHP] [5.98%]) were linked to birth certificate data. Diabetes during pregnancy included gestational and preexisting, defined by prenatal and maternal inpatient International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) diagnostic codes (i.e., 64801-64802, 64881-64882, or 25000-25092) or report on the birth certificate. Results: Diabetes prevalence from any source increased from 5.02% (95% confidence interval [CI]: 4.82-5.22) in 1996 to 8.37% (95% CI: 8.15-8.60) in 2008. Diabetes prevalence, standardized for maternal age and race/ethnicity from 1996 through 2008, increased from 3.38% (95% CI: 3.29-3.47) to 5.81% (95% CI: 5.71-5.91) using birth certificate data, from 3.99% (95% CI: 3.89-4.10) to 6.69% (95% CI: 6.58-6.80) using hospital discharge data, and from 4.74% (95% CI: 4.52-4.96) to 8.82% (95% CI: 8.61-9.03) using Medicaid data. Comparing birth certificate to hospital discharge, Medicaid, and SHP data, Cohen's kappa in 2008 was 0.73 (95% CI: 0.72-0.75), 0.64 (95% CI: 0.62-0.66), and 0.59 (95% CI: 0.54-0.65), respectively. Conclusions: An increasing prevalence of diabetes during pregnancy is reported, as well as substantial lack of agreement in reporting of diabetes prevalence across administrative databases. Prevalence of reported diabetes during pregnancy is impacted by screening, diagnostic, and reporting practices across different data sources, as well as by actual changes in prevalence over time. C1 [Lynch, Cheryl P.] Med Univ S Carolina, Dept Med, Charleston, SC 29425 USA. [Lynch, Cheryl P.; Hunt, Kelly J.] Ralph H Johnson Dept Vet Affairs Med Ctr, Hlth Equity & Rural Outreach Innovat Ctr, Charleston, SC USA. [Baker, Nathaniel; Korte, Jeffrey E.; Hunt, Kelly J.] Med Univ S Carolina, Dept Publ Hlth Sci, Charleston, SC 29425 USA. [Mauldin, Jill G.] Med Univ S Carolina, Dept Obstet & Gynecol, Charleston, SC 29425 USA. [Mayorga, Maria E.] N Carolina State Univ, Dept Ind & Syst Engn, Raleigh, NC 27695 USA. RP Hunt, KJ (reprint author), Med Univ S Carolina, Dept Publ Hlth Sci, 135 Cannon St,Suite 302, Charleston, SC 29425 USA. EM huntke@musc.edu FU National Institutes of Health [R01 MD004251] FX This work was supported by National Institutes of Health grant R01 MD004251 (PI Mayorga/Hunt). The funding agency did not participate in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the article. The article represents the views of the authors and not those of the Veterans Health Administration or Health Services Research and Development Service. NR 28 TC 3 Z9 3 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-9996 EI 1931-843X J9 J WOMENS HEALTH JI J. Womens Health PD APR 1 PY 2015 VL 24 IS 4 BP 316 EP 323 DI 10.1089/jwh.2014.4968 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Obstetrics & Gynecology; Women's Studies SC Public, Environmental & Occupational Health; General & Internal Medicine; Obstetrics & Gynecology; Women's Studies GA CF5YG UT WOS:000352632700008 PM 25786128 ER PT J AU Bouamar, H Jiang, DF Wang, L Lin, AP Ortega, M Aguiar, RCT AF Bouamar, Hakim Jiang, Daifeng Wang, Long Lin, An-Ping Ortega, Manoela Aguiar, Ricardo C. T. TI MicroRNA 155 Control of p53 Activity Is Context Dependent and Mediated by Aicda and Socs1 SO MOLECULAR AND CELLULAR BIOLOGY LA English DT Article ID INDUCED CYTIDINE DEAMINASE; B-CELL LYMPHOMA; SOMATIC HYPERMUTATION; BREAST-CANCER; EXPRESSION; MIR-155; GENE; AID; PATHWAY; PROTEIN AB In biological processes, the balance between positive and negative inputs is critical for an effective physiological response and to prevent disease. A case in point is the germinal center (GC) reaction, wherein high mutational and proliferation rates are accompanied by an obligatory suppression of the DNA repair machinery. Understandably, when the GC reaction goes awry, loss of immune cells or lymphoid cancer ensues. Here, we detail the functional interactions that make microRNA 155 (miR-155) a key part of this process. Upon antigen exposure, miR-155(-/-) mature B cells displayed significantly higher double-strand DNA break (DSB) accumulation and p53 activation than their miR-155(+/+) counterparts. Using B cell-specific knockdown strategies, we confirmed the role of the miR-155 target Aicda (activation-induced cytidine deaminase) in this process and, in combination with a gain-of-function model, unveiled a previously unappreciated role for Socs1 in directly modulating p53 activity and the DNA damage response in B lymphocytes. Thus, miR-155 controls the outcome of the GC reaction by modulating its initiation (Aicda) and termination (Socs1/p53 response), suggesting a mechanism to explain the quantitative defect in germinal center B cells found in mice lacking or overexpressing this miRNA. C1 [Bouamar, Hakim; Jiang, Daifeng; Wang, Long; Lin, An-Ping; Ortega, Manoela; Aguiar, Ricardo C. T.] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, Div Hematol & Med Oncol, San Antonio, TX 78229 USA. [Aguiar, Ricardo C. T.] Univ Texas Hlth Sci Ctr San Antonio, Canc Therapy & Res Ctr, San Antonio, TX 78229 USA. [Aguiar, Ricardo C. T.] Univ Texas Hlth Sci Ctr San Antonio, Greehey Childrens Canc Res Inst, San Antonio, TX 78229 USA. [Aguiar, Ricardo C. T.] Audie Murphy VA Hosp, South Texas Vet Hlth Care Syst, San Antonio, TX USA. RP Aguiar, RCT (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Med, Div Hematol & Med Oncol, San Antonio, TX 78229 USA. EM aguiarr@uthscsa.edu FU National Cancer Institute [R01-CA138747]; Young Investigator Award from the Voelcker Fund; Veterans Administration Merit Award [I01-BX001882]; National Cancer Institute Cancer Center Support Grant [P30 CA054174] FX This work was supported by a grant from the National Cancer Institute (R01-CA138747) (R.C.T.A), a Young Investigator Award from the Voelcker Fund (R.C.T. A), a Veterans Administration Merit Award (I01-BX001882), and a National Cancer Institute Cancer Center Support Grant (P30 CA054174). NR 37 TC 7 Z9 8 U1 2 U2 11 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0270-7306 EI 1098-5549 J9 MOL CELL BIOL JI Mol. Cell. Biol. PD APR PY 2015 VL 35 IS 8 BP 1329 EP 1340 DI 10.1128/MCB.01446-14 PG 12 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA CE3PX UT WOS:000351741500002 PM 25645925 ER PT J AU Maudsley, S Martin, B Gesty-Palmer, D Cheung, H Johnson, C Patel, S Becker, KG Wood, WH Zhang, YQ Lehrmann, E Luttrell, LM AF Maudsley, Stuart Martin, Bronwen Gesty-Palmer, Diane Cheung, Huey Johnson, Calvin Patel, Shamit Becker, Kevin G. Wood, William H., III Zhang, Yongqing Lehrmann, Elin Luttrell, Louis M. TI Delineation of a Conserved Arrestin-Biased Signaling Repertoire In Vivo SO MOLECULAR PHARMACOLOGY LA English DT Article ID BETA-ARRESTIN; PARATHYROID-HORMONE; FUNCTIONAL SELECTIVITY; RECEPTOR; EFFICACY; PATHWAYS; CANCER; BETA-ARRESTIN2; ACTIVATION; TOPOLOGY AB Biased G protein-coupled receptor agonists engender a restricted repertoire of downstream events from their cognate receptors, permitting them to produce mixed agonist-antagonist effects in vivo. While this opens the possibility of novel therapeutics, it complicates rational drug design, since the in vivo response to a biased agonist cannot be reliably predicted from its in cellula efficacy. We have employed novel informatic approaches to characterize the in vivo transcriptomic signature of the arrestin pathway-selective parathyroid hormone analog [D-Trp(12), Tyr(34)] bovine PTH(7-34) in six different murine tissues after chronic drug exposure. We find that [D-Trp(12), Tyr(34)] bovine PTH(7-34) elicits a distinctive arrestin-signaling focused transcriptomic response that is more coherently regulated across tissues than that of the pluripotent agonist, human PTH(1-34). This arrestin-focused network is closely associated with transcriptional control of cell growth and development. Our demonstration of a conserved arrestin-dependent transcriptomic signature suggests a framework within which the in vivo outcomes of arrestin-biased signaling may be generalized. C1 [Maudsley, Stuart; Martin, Bronwen; Patel, Shamit; Becker, Kevin G.; Wood, William H., III; Zhang, Yongqing; Lehrmann, Elin] NIA, NIH, Baltimore, MD 21224 USA. [Gesty-Palmer, Diane] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA. [Cheung, Huey; Johnson, Calvin] NIH, Ctr Informat Technol, Bethesda, MD 20892 USA. [Luttrell, Louis M.] Med Univ S Carolina, Dept Med, Charleston, SC 29425 USA. [Luttrell, Louis M.] Med Univ S Carolina, Dept Biochem & Mol Biol, Charleston, SC 29425 USA. [Luttrell, Louis M.] Ralph H Johnson Vet Affairs Med Ctr, Charleston, SC USA. RP Maudsley, S (reprint author), Univ Antwerp VIB, Dept Mol Genet, Univ Pl 1,Bldg V, B-2610 Antwerp, Belgium. EM stuart.maudsley@molgen.vib-ua.be FU Intramural Research Program of the National Institutes of Health National Institute on Aging; National Institutes of Health National Institute of General Medical Sciences [R01-GM095497]; National Institutes of Health National Institute of Diabetes, Digestive and Kidney Diseases [R01-DK055524]; National Institutes of Health National Institute of Child Health and Human Development [T32-HD043446]; Arthritis Foundation; Research Service of the Charleston, SC Veterans Affairs Medical Center FX This research was supported by the Intramural Research Program of the National Institutes of Health National Institute on Aging; the National Institutes of Health National Institute of General Medical Sciences [Grant R01-GM095497]; the National Institutes of Health National Institute of Diabetes, Digestive and Kidney Diseases [Grant R01-DK055524]; the National Institutes of Health National Institute of Child Health and Human Development [Grant T32-HD043446]; the Arthritis Foundation; and the Research Service of the Charleston, SC Veterans Affairs Medical Center. The contents of this article do not represent the views of the Department of Veterans Affairs or the United States Government. NR 48 TC 10 Z9 10 U1 2 U2 4 PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA SN 0026-895X EI 1521-0111 J9 MOL PHARMACOL JI Mol. Pharmacol. PD APR PY 2015 VL 87 IS 4 BP 706 EP 717 DI 10.1124/mol.114.095224 PG 12 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA CE7FT UT WOS:000352004100014 PM 25637603 ER PT J AU LeardMann, CA Woodall, KA Littman, AJ Jacobson, IG Boyko, EJ Smith, B Wells, TS Crum-Cianflone, NF AF LeardMann, Cynthia A. Woodall, Kelly A. Littman, Alyson J. Jacobson, Isabel G. Boyko, Edward J. Smith, Besa Wells, Timothy S. Crum-Cianflone, Nancy F. TI Post-Traumatic Stress Disorder Predicts Future Weight Change in the Millennium Cohort Study SO OBESITY LA English DT Article ID NATIONALLY REPRESENTATIVE SAMPLE; BODY-MASS INDEX; MILITARY SERVICE; PRIMARY-CARE; FOLLOW-UP; PRIME-MD; HEALTH; OBESITY; PTSD; US AB ObjectiveTo prospectively examine the association between post-traumatic stress disorder (PTSD) and weight change. MethodsLongitudinal analysis techniques were used to examine data (2001-2008) from Millennium Cohort Study participants, consisting of U.S. service members and veterans. Using the PTSD Checklist-Civilian Version, PTSD was assessed as none, resolved, new onset, or persistent. Subsequent weight change was assessed as stable (loss or gain), >3% weight loss, >3% but <10% weight gain, and 10% weight gain. ResultsOf the 38,352 participants, 2391 (6.2%) had PTSD (838 resolved, 1024 new onset, and 529 persistent), and 11% of participants subsequently had 10% weight gain. In multivariable models, PTSD was associated with higher odds of 10% weight gain (new onset OR: 1.44 [95% CI: 1.20-1.73]; persistent OR: 1.51 [CI: 1.17-1.96]; resolved OR: 1.30 [CI: 1.05-1.60]) compared with those without PTSD. New-onset and persistent PTSD were also associated with higher odds of >3% weight loss (OR: 1.41 [CI: 1.17-1.71]; OR: 1.42 [CI: 1.09-1.86], respectively). ConclusionsPTSD is independently associated with a higher risk of weight gain and loss, the former of which leads to a higher prevalence of overweight and obesity and a higher risk of comorbidities associated with excessive body adiposity. C1 [LeardMann, Cynthia A.; Woodall, Kelly A.; Jacobson, Isabel G.; Smith, Besa; Wells, Timothy S.; Crum-Cianflone, Nancy F.] Naval Hlth Res Ctr, Deployment Hlth Res Dept, San Diego, CA 92106 USA. [Littman, Alyson J.; Boyko, Edward J.] Vet Affairs Puget Sound Hlth Care Syst, Seattle Epidemiol Res & Informat Ctr, Seattle, WA USA. RP LeardMann, CA (reprint author), Naval Hlth Res Ctr, Deployment Hlth Res Dept, San Diego, CA 92106 USA. EM cynthia.leardmann@med.navy.mil OI Boyko, Edward/0000-0002-3695-192X FU Military Operational Medicine Research Program of the U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland; Veterans Affairs Puget Sound Health Care System; Rehabilitation Research VA Career Development Award [6982]; Department of Defense [60002] FX The Millennium Cohort Study is funded through the Military Operational Medicine Research Program of the U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland. Drs. Boyko and Littman's efforts in this project were supported by Veterans Affairs Puget Sound Health Care System. Dr. Littman's time was also supported in part through a Rehabilitation Research VA Career Development Award (#6982). This research represents Naval Health Research Center report 14-06, supported by the Department of Defense, under work unit no. 60002. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of the Army, Department of the Air Force, Department of Defense, Department of Veterans Affairs, or the U.S. Government. The funding organizations had no role in the design and conduct of the study; collection, analysis, or preparation of data; or preparation, review, or approval of the manuscript. Approved for public release; distribution is unlimited. NR 39 TC 4 Z9 4 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1930-7381 EI 1930-739X J9 OBESITY JI Obesity PD APR PY 2015 VL 23 IS 4 BP 886 EP 892 DI 10.1002/oby.21025 PG 7 WC Endocrinology & Metabolism; Nutrition & Dietetics SC Endocrinology & Metabolism; Nutrition & Dietetics GA CE4XA UT WOS:000351832400025 PM 25776806 ER PT J AU Gur, RC Braff, DL Calkins, ME Dobie, DJ Freedman, R Green, MF Greenwood, TA Lazzeroni, LC Light, GA Nuechterlein, KH Olincy, A Radant, AD Seidman, LJ Siever, LJ Silverman, JM Sprock, J Stone, WS Sugar, CA Swerdlow, NR Tsuang, DW Tsuang, MT Turetsky, BI Gur, RE AF Gur, Ruben C. Braff, David L. Calkins, Monica E. Dobie, Dorcas J. Freedman, Robert Green, Michael F. Greenwood, Tiffany A. Lazzeroni, Laura C. Light, Gregory A. Nuechterlein, Keith H. Olincy, Ann Radant, Allen D. Seidman, Larry J. Siever, Larry J. Silverman, Jeremy M. Sprock, Joyce Stone, William S. Sugar, Catherine A. Swerdlow, Neal R. Tsuang, Debby W. Tsuang, Ming T. Turetsky, Bruce I. Gur, Raquel E. TI Neurocognitive performance in family-based and case-control studies of schizophrenia SO SCHIZOPHRENIA RESEARCH LA English DT Article DE Neurocognition; Schizophrenia; Family-based; Case-control; Ascertainment ID COGNITIVE DEFICITS; 12 ENDOPHENOTYPES; SEX-DIFFERENCES; YOUNG-ADULTS; HIGH-RISK; GENETICS; CONSORTIUM; BATTERY; HERITABILITY; VALIDATION AB Background: Neurocognitive deficits in schizophrenia (SZ) are established and the Consortium on the Genetics of Schizophrenia (COGS) investigated such measures as endophenotypes in family-based (COGS-1) and case-control (COGS-2) studies. By requiring family participation, family-based sampling may result in samples that vary demographically and perform better on neurocognitive measures. Methods: The Penn computerized neurocognitive battery (CNB) evaluates accuracy and speed of performance for several domains and was administered across sites in COGS-1 and COGS-2. Most tests were included in both studies. COGS-1 included 328 patients with SZ and 497 healthy comparison subjects (HCS) and COGS-2 included 1195 patients and 1009 HCS. Results: Demographically, COGS-1 participants were younger, more educated, with more educated parents and higher estimated IQ compared to COGS-2 participants. After controlling for demographics, the two samples produced very similar performance profiles compared to their respective controls. As expected, performance was better and with smaller effect sizes compared to controls in COGS-1 relative to COGS-2. Better performance was most pronounced for spatial processing while emotion identification had large effect sizes for both accuracy and speed in both samples. Performance was positively correlated with functioning and negatively with negative and positive symptoms in both samples, but correlations were attenuated in COGS-2, especially with positive symptoms. Conclusions: Patients ascertained through family-based design have more favorable demographics and better performance on some neurocognitive domains. Thus, studies that use case-control ascertainment may tap into populations with more severe forms of illness that are exposed to less favorable factors compared to those ascertained with family-based designs. Published by Elsevier B.V. C1 [Gur, Ruben C.; Calkins, Monica E.; Turetsky, Bruce I.; Gur, Raquel E.] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA. [Braff, David L.; Greenwood, Tiffany A.; Light, Gregory A.; Sprock, Joyce; Swerdlow, Neal R.; Tsuang, Ming T.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA. [Braff, David L.; Greenwood, Tiffany A.; Light, Gregory A.; Sprock, Joyce; Swerdlow, Neal R.; Tsuang, Ming T.] VA San Diego Healthcare Syst, VISN 22 Mental Illness Res Educ & Clin Ctr MIRECC, San Diego, CA USA. [Dobie, Dorcas J.; Radant, Allen D.; Tsuang, Debby W.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [Dobie, Dorcas J.; Radant, Allen D.; Tsuang, Debby W.] VA Puget Sound Hlth Care Syst, Seattle, WA USA. [Freedman, Robert; Olincy, Ann] Univ Colorado Denver, Dept Psychiat, Aurora, CO USA. [Green, Michael F.; Nuechterlein, Keith H.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA. [Green, Michael F.; Nuechterlein, Keith H.] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. [Lazzeroni, Laura C.] Stanford Univ, Dept Psychiat, Palo Alto, CA 94304 USA. [Seidman, Larry J.; Stone, William S.] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA. [Seidman, Larry J.; Stone, William S.] Beth Israel Deaconess Med Ctr, Massachusetts Mental Hlth Ctr, Publ Psychiat Div, Boston, MA 02215 USA. [Siever, Larry J.; Silverman, Jeremy M.] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA. [Siever, Larry J.; Silverman, Jeremy M.] James J Peters VA Med Ctr, New York, NY USA. [Sugar, Catherine A.] Univ Calif Los Angeles, Sch Publ Hlth, Dept Biostat, Los Angeles, CA 90024 USA. RP Gur, RC (reprint author), Univ Penn, Dept Psychiat, Neuropsychiat Sect, Perelman Sch Med, 3400 Spruce, Philadelphia, PA 19104 USA. EM gur@upenn.edu RI ; Tsuang, Debby/L-7234-2016 OI Greenwood, Tiffany/0000-0002-6080-6503; Tsuang, Debby/0000-0002-4716-1894; Lazzeroni, Laura/0000-0002-1846-6920 FU National Institute of Mental Health; COGS-1 [MH065571 UCSD, MH065707 UCLA, MH065554 MSSM]; COGS-2 [MH065571 UCSD, MH065707 UCLA, MH065554 MSSM]; COGS-1, Penn [MH065578]; COGS-2, Penn [MH065578]; COGS-1, Washington [MH065558]; COGS-2, Washington [MH065558]; COGS-1, Colorado [MH065588]; COGS-1, Harvard [MH065562]; COGS-1, Seidman; COGS-1, Stone; COGS-2, Stanford [MH86135] FX This work was supported by collaborative R01 grants from the National Institute of Mental Health. COGS-1 and COGS-2: MH065571 UCSD, MH065707 UCLA, MH065554 MSSM, MH065578 Penn, MH065558 Washington; COGS-1 Only: MH065588 Colorado, MH065562 Harvard; Seidman and Stone are on a subcontract for COGS-2; COGS-2 Only: MH86135 Stanford. NR 43 TC 8 Z9 8 U1 2 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0920-9964 EI 1573-2509 J9 SCHIZOPHR RES JI Schizophr. Res. PD APR PY 2015 VL 163 IS 1-3 BP 17 EP 23 DI 10.1016/j.schres.2014.10.049 PG 7 WC Psychiatry SC Psychiatry GA CE6EE UT WOS:000351928600003 PM 25432636 ER PT J AU Lee, J Green, MF Calkins, ME Greenwood, TA Gur, RE Gur, RC Lazzeroni, LC Light, GA Nuechterlein, KH Radant, AD Seidman, LJ Siever, LJ Silverman, JM Sprock, J Stone, WS Sugar, CA Swerdlow, NR Tsuang, DW Tsuang, MT Turetsky, BI Braff, DL AF Lee, Junghee Green, Michael F. Calkins, Monica E. Greenwood, Tiffany A. Gur, Raquel E. Gur, Ruben C. Lazzeroni, Laura C. Light, Gregory A. Nuechterlein, Keith H. Radant, Allen D. Seidman, Larry J. Siever, Larry J. Silverman, Jeremy M. Sprock, Joyce Stone, William S. Sugar, Catherine A. Swerdlow, Neal R. Tsuang, Debby W. Tsuang, Ming T. Turetsky, Bruce I. Braff, David L. TI Verbal working memory in schizophrenia from the Consortium on the Genetics of Schizophrenia (COGS) Study: The moderating role of smoking status and antipsychotic medications SO SCHIZOPHRENIA RESEARCH LA English DT Article DE Schizophrenia; Verbal working memory; Letter-Number span; Moderators; Smoking; Antipsychotic medication ID CIGARETTE-SMOKING; 1ST-EPISODE SCHIZOPHRENIA; COGNITIVE FUNCTION; 12 ENDOPHENOTYPES; DOPAMINE RELEASE; CLINICAL-TRIALS; BRAIN-FUNCTION; SUBSTANCE USE; NICOTINE; DEFICITS AB Objectives: Working memory impairment has been extensively studied in schizophrenia, but less is known about moderators of the impairment. Using the Consortium on the Genetics of Schizophrenia case-control study (COGS-2), we examined smoking status, types of antipsychotic medication, and history of substance as moderators for working memory impairment in schizophrenia. Methods: From 5 sites, 1377 patients with schizophrenia or schizoaffective, depressed type and 1037 healthy controls completed the letter-number span (LNS) task. The LNS uses intermixed letter and digit stimuli that increase from 2 up to 8 stimuli. In the forward condition, participants repeated the letters and numbers in the order they were presented. In the reorder condition, participants repeated the digits in ascending order followed by letters in alphabetical order. Results: Schizophrenia patients performed more poorly than controls, with a larger difference on reorder than forward conditions. Deficits were associated with symptoms, functional capacity, and functional outcome. Patients who smoked showed larger impairment than nonsmoking patients, primarily due to deficits on the reorder condition. The impairing association of smoking was more pronounced among patients taking first-generation than those taking second-generation antipsychotic medications. Correlations between working memory and community functioning were stronger for nonsmokers. History of substance use did not moderate working memory impairment. Conclusions: Results confirm the working memory impairment in schizophrenia, and indicate smoking status as an important moderator for these deficits. The greater impairment in smokers may reflect added burden of smoking on general health or that patients with greater deficits are more likely to smoke. (C) 2014 Elsevier B.V. All rights reserved. C1 [Lee, Junghee; Green, Michael F.; Nuechterlein, Keith H.; Sugar, Catherine A.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA. [Lee, Junghee; Green, Michael F.; Sugar, Catherine A.] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. [Calkins, Monica E.; Gur, Raquel E.; Gur, Ruben C.; Turetsky, Bruce I.] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA. [Greenwood, Tiffany A.; Light, Gregory A.; Sprock, Joyce; Swerdlow, Neal R.; Tsuang, Ming T.; Braff, David L.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA. [Lazzeroni, Laura C.] Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA. [Lazzeroni, Laura C.] Stanford Univ, Dept Pediat, Stanford, CA 94305 USA. [Light, Gregory A.; Sprock, Joyce; Braff, David L.] VA San Diego Healthcare Syst, Mental Illness Res Educ & Clin Ctr MIREC, VISN22, San Diego, CA USA. [Radant, Allen D.; Tsuang, Debby W.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [Radant, Allen D.; Tsuang, Debby W.] VA Puget Sound Healthcare Syst, Seattle, WA USA. [Seidman, Larry J.; Stone, William S.] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA. [Seidman, Larry J.; Stone, William S.] Beth Israel Deaconess Med Ctr, Massachusetts Mental Hlth Ctr, Publ Psychiat Devis, Boston, MA 02215 USA. [Siever, Larry J.; Silverman, Jeremy M.] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA. [Siever, Larry J.; Silverman, Jeremy M.] James J Peters VA Med Ctr, New York, NY USA. [Sugar, Catherine A.] Univ Calif Los Angeles, Dept Biostat, Los Angeles, CA 90024 USA. [Tsuang, Ming T.] Univ Calif San Diego, Inst Genom Med, San Diego, CA 92103 USA. [Tsuang, Ming T.] Harvard Inst Psychiat Epidemiol & Genet, Boston, MA USA. RP Lee, J (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, 760 Westwood Plaza,77-361, Los Angeles, CA 90024 USA. EM jungheelee@ucla.edu RI Lee, Junghee/C-5226-2014; Tsuang, Debby/L-7234-2016 OI Lee, Junghee/0000-0001-9567-8700; Tsuang, Debby/0000-0002-4716-1894; Lazzeroni, Laura/0000-0002-1846-6920; Greenwood, Tiffany/0000-0002-6080-6503 FU National Institute of Health FX Other than providing support, the National Institute of Health does not have any further role in this manuscript. NR 64 TC 9 Z9 9 U1 3 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0920-9964 EI 1573-2509 J9 SCHIZOPHR RES JI Schizophr. Res. PD APR PY 2015 VL 163 IS 1-3 BP 24 EP 31 DI 10.1016/j.schres.2014.08.014 PG 8 WC Psychiatry SC Psychiatry GA CE6EE UT WOS:000351928600004 PM 25248939 ER PT J AU Stone, WS Mesholam-Gately, RI Braff, DL Calkins, ME Freedman, R Green, MF Greenwood, TA Gur, RE Gur, RC Lazzeroni, LC Light, GA Nuechterlein, KH Olincy, A Radant, AD Siever, LJ Silverman, JM Sprock, J Sugar, CA Swerdlow, NR Tsuang, DW Tsuang, MT Turetsky, BI Seidman, LJ AF Stone, William S. Mesholam-Gately, Raquelle I. Braff, David L. Calkins, Monica E. Freedman, Robert Green, Michael F. Greenwood, Tiffany A. Gur, Raquel E. Gur, Ruben C. Lazzeroni, Laura C. Light, Gregory A. Nuechterlein, Keith H. Olincy, Ann Radant, Allen D. Siever, Larry J. Silverman, Jeremy M. Sprock, Joyce Sugar, Catherine A. Swerdlow, Neal R. Tsuang, Debby W. Tsuang, Ming T. Turetsky, Bruce I. Seidman, Larry J. TI California Verbal Learning Test-II performance in schizophrenia as a function of ascertainment strategy: Comparing the first and second phases of the Consortium on the Genetics of Schizophrenia (COGS) SO SCHIZOPHRENIA RESEARCH LA English DT Article DE Endophenotype; Verbal learning; Memory; Schizophrenia; California Verbal Learning Test ID COGNITIVE DEFICITS; 1ST-EPISODE SCHIZOPHRENIA; 1ST-DEGREE RELATIVES; 12 ENDOPHENOTYPES; FAMILIAL RISK; MEMORY; NEUROCOGNITION; HERITABILITY; DISORDER AB The first phase of the Consortium on the Genetics of Schizophrenia (COGS-1) showed performance deficits in learning and memory on the California Verbal Learning Test, Second Edition (CVLT-II) in individuals with schizophrenia (SZ), compared to healthy comparison subjects (HCS). A question is whether the COGS-1 study, which used a family study design (i.e. studying relatively intact families), yielded "milder" SZ phenotypes than those acquired subsequently in the COGS-2 case-control design that did not recruit unaffected family members. CVLT-II performance was compared for the COGS-1 and COGS-2 samples. Analyses focused on learning, recall and recognition variables, with age, gender and education as covariates. Analyses of COGS-2 data explored effects of additional covariates and moderating factors in CVLT-II performance. 324 SZ subjects and 510 HCS had complete CVLT-II and covariate data in COGS-1, while 1356 SZ and 1036 HCS had complete data in COGS-2. Except for recognition memory, analysis of covariance showed significantly worse performance in COGS-2 on all CVLT-II variables for SZ and HCS, and remained significant in the presence of the covariates. Performance in each of the 5 learning trials differed significantly. However, effect sizes comparing cases and controls were comparable across the two studies. COGS-2 analyses confirmed SZ performance deficits despite effects of multiple significant covariates and moderating factors. CVLT-II performance was worse in COGS-2 than in COGS-1 for both the SZ and the HCS in this large cohort, likely due to cohort effects. Demographically corrected data yield a consistent pattern of performance across the two studies in SZ. (C) 2014 Published by Elsevier B.V. C1 [Stone, William S.; Mesholam-Gately, Raquelle I.; Seidman, Larry J.] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA. [Stone, William S.; Mesholam-Gately, Raquelle I.; Seidman, Larry J.] Beth Israel Deaconess Med Ctr, Massachusetts Mental Hlth Ctr, Publ Psychiat Div, Boston, MA 02215 USA. [Braff, David L.; Greenwood, Tiffany A.; Light, Gregory A.; Sprock, Joyce; Swerdlow, Neal R.; Tsuang, Ming T.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA. [Calkins, Monica E.; Gur, Raquel E.; Gur, Ruben C.; Turetsky, Bruce I.] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA. [Green, Michael F.; Nuechterlein, Keith H.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Behav Sci, Los Angeles, CA 90095 USA. [Green, Michael F.] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. [Lazzeroni, Laura C.] Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA. [Radant, Allen D.; Tsuang, Debby W.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [Radant, Allen D.; Tsuang, Debby W.] VA Puget Sound Hlth Care Syst, Seattle, WA USA. [Siever, Larry J.; Silverman, Jeremy M.] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA. [Siever, Larry J.; Silverman, Jeremy M.] James J Peters VA Med Ctr, New York, NY USA. [Sugar, Catherine A.] Univ Calif Los Angeles, Sch Publ Hlth, Dept Biostat, Los Angeles, CA 90024 USA. [Tsuang, Debby W.] Univ Calif San Diego, Inst Genom Med, La Jolla, CA 92093 USA. [Tsuang, Ming T.] Harvard Inst Psychiat Epidemiol & Genet, Boston, MA USA. [Braff, David L.; Light, Gregory A.; Tsuang, Ming T.] VA San Diego Healthcare Syst, VISN 22 Mental Illness Res Educ & Clin Ctr MIRECC, San Diego, CA USA. [Freedman, Robert; Olincy, Ann] Univ Colorado, Hlth Sci Ctr, Dept Psychiat, Denver, CO 80262 USA. [Lazzeroni, Laura C.] Stanford Univ, Dept Pediat, Stanford, CA 94305 USA. RP Stone, WS (reprint author), Massachusetts Mental Hlth Ctr, 75 Fenwood Rd, Boston, MA 02115 USA. EM wstone@bidmc.harvard.edu RI Tsuang, Debby/L-7234-2016 OI Tsuang, Debby/0000-0002-4716-1894; Lazzeroni, Laura/0000-0002-1846-6920; Greenwood, Tiffany/0000-0002-6080-6503 FU NIH FX Other than providing support, the NIH had no further role in this manuscript. NR 38 TC 4 Z9 4 U1 1 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0920-9964 EI 1573-2509 J9 SCHIZOPHR RES JI Schizophr. Res. PD APR PY 2015 VL 163 IS 1-3 BP 32 EP 37 DI 10.1016/j.schres.2014.10.029 PG 6 WC Psychiatry SC Psychiatry GA CE6EE UT WOS:000351928600005 PM 25497440 ER PT J AU Nuechterlein, KH Green, MF Calkins, ME Greenwood, TA Gur, RE Gur, RC Lazzeroni, LC Light, GA Radant, AD Seidman, LJ Siever, LJ Silverman, JM Sprock, J Stone, WS Sugar, CA Swerdlow, NR Tsuang, DW Tsuang, MT Turetsky, BI Braff, DL AF Nuechterlein, Keith H. Green, Michael F. Calkins, Monica E. Greenwood, Tiffany A. Gur, Raquel E. Gur, Ruben C. Lazzeroni, Laura C. Light, Gregory A. Radant, Allen D. Seidman, Larry J. Siever, Larry J. Silverman, Jeremy M. Sprock, Joyce Stone, William S. Sugar, Catherine A. Swerdlow, Neal R. Tsuang, Debby W. Tsuang, Ming T. Turetsky, Bruce I. Braff, David L. TI Attention/vigilance in schizophrenia: Performance results from a large multi-site study of the Consortium on the Genetics of Schizophrenia (COGS) SO SCHIZOPHRENIA RESEARCH LA English DT Article DE Schizophrenia; Endophenotype; Attention; Continuous Performance Test; Cognition; Functional capacity; Genetics ID SUSTAINED ATTENTION DEFICITS; IDENTICAL PAIRS VERSION; REMITTED SCHIZOPHRENICS; NONPSYCHOTIC RELATIVES; 1ST-DEGREE RELATIVES; IMPAIRED ATTENTION; COGNITIVE FUNCTION; 12 ENDOPHENOTYPES; SIGNAL-DETECTION; SUBSTANCE USE AB Attention/vigilance impairments are present in individuals with schizophrenia across psychotic and remitted states and in their first-degree relatives. An important question is whether deficits in attention/vigilance can be consistently and reliably measured across sites varying in many participant demographic, clinical, and functional characteristics, as needed for large-scale genetic studies of endophenotypes. We examined Continuous Performance Test (CPT) data from phase 2 of the Consortium on the Genetics of Schizophrenia (COGS-2), the largest-scale assessment of cognitive and psychophysiological endophenotypes relevant to schizophrenia. The CPT data from 2251 participants from five sites were examined. A perceptual-load vigilance task (the Degraded Stimulus CPT or DS-CPT) and a memory-load vigilance task (CPT-Identical Pairs or CPT-IP) were utilized. Schizophrenia patients performed more poorly than healthy comparison subjects (HCS) across sites, despite significant site differences in participant age, sex, education, and racial distribution. Patient-HCS differences in signal/noise discrimination (d') in the DS-CPT varied significantly across sites, but averaged a medium effect size. CPT-IP performance showed large patient-HCS differences across sites. Poor CPT performance was independent of or weakly correlated with symptom severity, but was significantly associated with lower educational achievement and functional capacity. Current smoking was associated with poorer CPT-IP d'. Patients taking both atypical and typical antipsychotic medication performed more poorly than those on no or atypical antipsychotic medications, likely reflecting their greater severity of illness. We conclude that CPT deficits in schizophrenia can be reliably detected across sites, are relatively independent of current symptom severity, and are related to functional capacity. (C) 2015 Elsevier B.V. All rights reserved. C1 [Nuechterlein, Keith H.; Green, Michael F.; Sugar, Catherine A.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Behav Sci, Los Angeles, CA 90095 USA. [Green, Michael F.; Sugar, Catherine A.] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. [Calkins, Monica E.; Gur, Raquel E.; Gur, Ruben C.; Turetsky, Bruce I.] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA. [Greenwood, Tiffany A.; Light, Gregory A.; Sprock, Joyce; Swerdlow, Neal R.; Tsuang, Ming T.; Braff, David L.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA. [Lazzeroni, Laura C.] Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA. [Lazzeroni, Laura C.] Stanford Univ, Dept Pediat, Stanford, CA 94305 USA. [Light, Gregory A.; Sprock, Joyce; Braff, David L.] VA San Diego Healthcare Syst, Mental Illness Res Educ & Clin Ctr MIRECC, VISN22, San Diego, CA USA. [Radant, Allen D.; Tsuang, Debby W.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [Radant, Allen D.; Tsuang, Debby W.] VA Puget Sound Healthcare Syst, Seattle, WA USA. [Seidman, Larry J.; Stone, William S.] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA. [Seidman, Larry J.; Stone, William S.] Beth Israel Deaconess Med Ctr, Massachusetts Mental Hlth Ctr, Publ Psychiat Div, Boston, MA 02215 USA. [Siever, Larry J.; Silverman, Jeremy M.] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA. [Siever, Larry J.; Silverman, Jeremy M.] James J Peters VA Med Ctr, New York, NY USA. [Sugar, Catherine A.] Univ Calif Los Angeles, Dept Biostat, Los Angeles, CA USA. [Tsuang, Ming T.] Univ Calif San Diego, Inst Genom Med, San Diego, CA 92103 USA. [Tsuang, Ming T.] Univ Calif San Diego, Dept Psychiat, Ctr Behav Genom, San Diego, CA 92103 USA. [Tsuang, Ming T.] Harvard Inst Psychiat Epidemiol & Genet, Boston, MA USA. RP Nuechterlein, KH (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Behav Sci, 300 UCLA Med Plaza,Room 2240, Los Angeles, CA 90095 USA. EM keithn@ucla.edu RI Tsuang, Debby/L-7234-2016 OI Tsuang, Debby/0000-0002-4716-1894; Nuechterlein, Keith/0000-0002-8179-8952; Lazzeroni, Laura/0000-0002-1846-6920; Greenwood, Tiffany/0000-0002-6080-6503 FU National Institutes of Health FX Beyond providing funding support, the National Institutes of Health does not have any further role in this manuscript. NR 66 TC 6 Z9 6 U1 2 U2 10 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0920-9964 EI 1573-2509 J9 SCHIZOPHR RES JI Schizophr. Res. PD APR PY 2015 VL 163 IS 1-3 BP 38 EP 46 DI 10.1016/j.schres.2015.01.017 PG 9 WC Psychiatry SC Psychiatry GA CE6EE UT WOS:000351928600006 PM 25749017 ER PT J AU Radant, AD Steven, PM Braff, DL Calkins, ME Dobie, DJ Freedman, R Green, MF Greenwood, TA Gur, RE Gur, RC Lazzeroni, LC Light, GA Meichle, SP Nuechterlein, KH Olincy, A Seidman, LJ Siever, LJ Silverman, JM Stone, WS Swerdlow, NR Sugar, CA Tsuang, MT Turetsky, BI Tsuang, DW AF Radant, Allen D. Millard, Steven P. Braff, David L. Calkins, Monica E. Dobie, Dorcas J. Freedman, Robert Green, Michael F. Greenwood, Tiffany A. Gur, Raquel E. Gur, Ruben C. Lazzeroni, Laura C. Light, Gregory A. Meichle, Sean P. Nuechterlein, Keith H. Olincy, Ann Seidman, Larry J. Siever, Larry J. Silverman, Jeremy M. Stone, William S. Swerdlow, Neal R. Sugar, Catherine A. Tsuang, Ming T. Turetsky, Bruce I. Tsuang, Debby W. TI Robust differences in antisaccade performance exist between COGS schizophrenia cases and controls regardless of recruitment strategies SO SCHIZOPHRENIA RESEARCH LA English DT Article DE Antisaccade task; Recruitment ID 12 ENDOPHENOTYPES; CONSORTIUM; GENETICS; TASK AB The impaired ability to make correct antisaccades (i.e., antisaccade performance) is well documented among schizophrenia subjects, and researchers have successfully demonstrated that antisaccade performance is a valid schizophrenia endophenotype that is useful for genetic studies. However, it is unclear how the ascertainment biases that unavoidably result from recruitment differences in schizophrenia subjects identified in family versus case-control studies may influence patient-control differences in antisaccade performance. To assess the impact of ascertainment bias, researchers from the Consortium on the Genetics of Schizophrenia (COGS) compared antisaccade performance and antisaccade metrics (latency and gain) in schizophrenia and control subjects from COGS-1, a family-based schizophrenia study, to schizophrenia and control subjects from COGS-2, a corresponding case-control study. COGS-2 schizophrenia subjects were substantially older; had lower education status, worse psychosocial function, and more severe symptoms; and were three times more likely to be a member of a multiplex family than COGS-1 schizophrenia subjects. Despite these variations, which were likely the result of ascertainment differences (as described in the introduction to this special issue), the effect sizes of the control-schizophrenia differences in antisaccade performance were similar in both studies (Cohen's d effect size of 1.06 and 1.01 in COGS-1 and COGS-2, respectively). This suggests that, in addition to the robust, state-independent schizophrenia-related deficits described in endophenotype studies, group differences in antisaccade performance do not vary based on subject ascertainment and recruitment factors. Published by Elsevier B.V. C1 [Radant, Allen D.; Dobie, Dorcas J.; Tsuang, Debby W.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [Radant, Allen D.] Mental Hlth Serv, Dept Vet Affairs DVA, VISN 20, Seattle, WA USA. [Millard, Steven P.; Dobie, Dorcas J.; Meichle, Sean P.] Mental Illness Res Educ & Clin Ctr MIRECC, DVA, VISN 20, Seattle, WA USA. [Braff, David L.; Greenwood, Tiffany A.; Light, Gregory A.; Swerdlow, Neal R.; Tsuang, Ming T.] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA. [Calkins, Monica E.; Gur, Raquel E.; Gur, Ruben C.; Turetsky, Bruce I.] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA. [Freedman, Robert; Olincy, Ann] Univ Colorado, Hlth Sci Ctr, Dept Psychiat, Aurora, CO USA. [Green, Michael F.; Nuechterlein, Keith H.; Sugar, Catherine A.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Behav Sci, Los Angeles, CA 90095 USA. [Lazzeroni, Laura C.] Stanford Univ, Dept Biostat, Palo Alto, CA 94304 USA. [Seidman, Larry J.; Stone, William S.] Harvard Univ, Sch Med, Massachusetts Mental Hlth Ctr,Dept Psychiat,Publ, Beth Israel Deaconess Med Ctr,Harvard Inst Psychi, Boston, MA 02115 USA. [Siever, Larry J.; Silverman, Jeremy M.] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA. [Siever, Larry J.; Silverman, Jeremy M.] James J Peters VA Med Ctr, MIRECC, DVA, VISN 3, Bronx, NY USA. [Braff, David L.] San Diego Healthcare Syst, DVA, VISN 22 MIRECC, San Diego, CA USA. [Tsuang, Debby W.] Geriatr Res Educ & Clin Ctr, DVA, VISN 20, Seattle, WA USA. RP Tsuang, DW (reprint author), VA Puget Sound Hlth Care Syst, GRECC 182,1660 S Columbian Way, Seattle, WA 98108 USA. RI Tsuang, Debby/L-7234-2016 OI Tsuang, Debby/0000-0002-4716-1894; Lazzeroni, Laura/0000-0002-1846-6920; Greenwood, Tiffany/0000-0002-6080-6503 FU Office of Research and Development Medical Research Service, Department of Veterans Affairs; Office of Health Services R&D Service, Department of Veterans Affairs; NIMH [R01 MH65571, R01 MH65588, R01 MH65562, R01 MH65707, R01 MH65554, R01 MH65578, R01 MH65558] FX This material is based upon work supported (or supported in part) by the Office of Research and Development Medical Research Service (or) Health Services R&D Service, Department of Veterans Affairs. This study was supported by NIMH grants R01 MH65571, R01 MH65588, R01 MH65562, R01 MH65707, R01 MH65554, R01 MH65578, and R01 MH65558. NR 26 TC 2 Z9 2 U1 1 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0920-9964 EI 1573-2509 J9 SCHIZOPHR RES JI Schizophr. Res. PD APR PY 2015 VL 163 IS 1-3 BP 47 EP 52 DI 10.1016/j.schres.2014.12.016 PG 6 WC Psychiatry SC Psychiatry GA CE6EE UT WOS:000351928600007 PM 25553977 ER PT J AU Turetsky, BI Dress, EM Braff, DL Calkins, ME Green, MF Greenwood, TA Gur, RE Gur, RC Lazzeroni, LC Nuechterlein, KH Radant, AD Seidman, LJ Siever, LJ Silverman, JM Sprock, J Stone, WS Sugar, CA Swerdlow, NR Tsuang, DW Tsuang, MT Light, G AF Turetsky, Bruce I. Dress, Erich M. Braff, David L. Calkins, Monica E. Green, Michael F. Greenwood, Tiffany A. Gur, Raquel E. Gur, Ruben C. Lazzeroni, Laura C. Nuechterlein, Keith H. Radant, Allen D. Seidman, Larry J. Siever, Larry J. Silverman, Jeremy M. Sprock, Joyce Stone, William S. Sugar, Catherine A. Swerdlow, Neal R. Tsuang, Debby W. Tsuang, Ming T. Light, Gregory TI The utility of P300 as a schizophrenia endophenotype and predictive biomarker: Clinical and socio-demographic modulators in COGS-2 SO SCHIZOPHRENIA RESEARCH LA English DT Article DE P300; Schizophrenia; Endophenotype; Biomarker; Event-related potential ID EVENT-RELATED POTENTIALS; SUBCOMPONENT ABNORMALITIES; AUDITORY ODDBALL; HIGH-RISK; FUNCTIONAL-CAPACITY; MENTAL STATE; AMPLITUDE; PSYCHOSIS; BRAIN; TOPOGRAPHY AB Reduced auditory P300 amplitude is a robust schizophrenia deficit exhibiting the qualities of a viable genetic endophenotype. These include heritability, test-retest reliability, and trait-like stability. Recent evidence suggests that P300 may also serve as a predictive biomarker for transition to psychosis during the schizophrenia prodrome. Historically, the utility of the P300 has been limited by its clinical nonspecificity, cross-site measurement variability, and required EEG expertise. The Consortium on the Genetics of Schizophrenia (COGS-2) study provided an opportunity to examine the consistency of the measure across multiple sites with varying degrees of EEG experience, and to identify important modulating factors that contribute to measurement variability. Auditory P300 was acquired from 649 controls and 587 patients at 5 sites. An overall patient deficit was observed with effect size 0.62. Each site independently observed a significant patient deficit, but site differences also existed. In patients, site differences reflected clinical differences in positive symptomatology and functional capacity. In controls, site differences reflected differences in racial stratification, smoking and substance use history. These factors differentially suppressed the P300 response, but only in control subjects. This led to an attenuated patient-control difference among smokers and among African Americans with history of substance use. These findings indicate that the P300 can be adequately assessed quantitatively, across sites, without substantial EEG expertise. Measurements are suitable for both genetic endophenotype analyses and studies of psychosis risk and conversion. However, careful attention must be given to selection of appropriate comparison samples to avoid misleading false negative results. (C) 2014 Elsevier B.V. All rights reserved. C1 [Turetsky, Bruce I.; Dress, Erich M.; Calkins, Monica E.; Gur, Raquel E.; Gur, Ruben C.] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA. [Braff, David L.; Greenwood, Tiffany A.; Sprock, Joyce; Tsuang, Ming T.; Light, Gregory] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA. [Braff, David L.; Light, Gregory] VA San Diego Healthcare Syst, Mental Illness Res Educ & Clin Ctr MIRECC, VISN 22, San Diego, CA USA. [Green, Michael F.; Nuechterlein, Keith H.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA. [Green, Michael F.] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. [Lazzeroni, Laura C.] Stanford Univ, Dept Psychiat & Behav Sci, Palo Alto, CA 94304 USA. [Radant, Allen D.; Tsuang, Debby W.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [Radant, Allen D.; Tsuang, Debby W.] VA Puget Sound Hlth Care Syst, Seattle, WA USA. [Seidman, Larry J.; Stone, William S.] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA. [Seidman, Larry J.; Stone, William S.] Beth Israel Deaconess Med Ctr, Massachusetts Mental Hlth Ctr, Publ Psychiat Div, Boston, MA 02215 USA. [Siever, Larry J.; Silverman, Jeremy M.] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA. [Siever, Larry J.; Silverman, Jeremy M.] James J Peters VA Med Ctr, New York, NY USA. [Sugar, Catherine A.] Univ Calif Los Angeles, Sch Publ Hlth, Dept Biostat, Los Angeles, CA 90024 USA. [Tsuang, Ming T.] Univ Calif San Diego, Ctr Behav Genom, La Jolla, CA 92093 USA. [Tsuang, Ming T.] Univ Calif San Diego, Inst Genom Med, La Jolla, CA 92093 USA. [Tsuang, Ming T.] Harvard Inst Psychiat Epidemiol & Genet, Boston, MA USA. RP Turetsky, BI (reprint author), Univ Penn, Dept Psychiat, Perelman Sch Med, 10th Floor,Gates Bldg,3400 Spruce, Philadelphia, PA 19104 USA. EM turetsky@upenn.edu RI Tsuang, Debby/L-7234-2016 OI Tsuang, Debby/0000-0002-4716-1894; Lazzeroni, Laura/0000-0002-1846-6920; Greenwood, Tiffany/0000-0002-6080-6503 FU National Institute of Mental Health [MH065571, MH065707, MH065554, MH065578, MH065558, MH86135]; NIMH FX This work was supported by collaborative R01 grants from the National Institute of Mental Health: MH065571, MH065707, MH065554, MH065578, MH065558, MH86135. Other than providing financial support, the NIMH had no further role in this manuscript. NR 64 TC 12 Z9 15 U1 0 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0920-9964 EI 1573-2509 J9 SCHIZOPHR RES JI Schizophr. Res. PD APR PY 2015 VL 163 IS 1-3 BP 53 EP 62 DI 10.1016/j.schres.2014.09.024 PG 10 WC Psychiatry SC Psychiatry GA CE6EE UT WOS:000351928600008 PM 25306203 ER PT J AU Light, GA Swerdlowa, NR Thomas, ML Calkins, ME Green, MF Greenwood, TA Gur, RE Gur, RC Lazzeroni, LC Nuechterlein, KH Pela, M Radant, AD Seidman, LJ Sharp, RF Siever, LJ Silverman, JM Sprock, J Stone, WS Sugar, CA Tsuang, DW Tsuang, MT Braff, DL Turetsky, BI AF Light, Gregory A. Swerdlowa, Neal R. Thomas, Michael L. Calkins, Monica E. Green, Michael F. Greenwood, Tiffany A. Gur, Raquel E. Gur, Ruben C. Lazzeroni, Laura C. Nuechterlein, Keith H. Pela, Marlena Radant, Allen D. Seidman, Larry J. Sharp, Richard F. Siever, Larry J. Silverman, Jeremy M. Sprock, Joyce Stone, William S. Sugar, Catherine A. Tsuang, Debby W. Tsuang, Ming T. Braff, David L. Turetsky, Bruce I. TI Validation of mismatch negativity and P3a for use inmulti-site studies of schizophrenia: Characterization of demographic, clinical, cognitive, and functional correlates in COGS-2 SO SCHIZOPHRENIA RESEARCH LA English DT Article DE Schizophrenia; Mismatch negativity; P300; P3a; Cognition; Function; EEG ID EVENT-RELATED POTENTIALS; AUDITORY SENSORY MEMORY; HIGH-RISK; 1ST-EPISODE PSYCHOSIS; PROCESSING DEFICITS; HEALTHY-VOLUNTEERS; DURATION; NICOTINE; BRAIN; ATTENTION AB Mismatch negativity (MMN) and P3a are auditory event-related potential (ERP) components that show robust deficits in schizophrenia (SZ) patients and exhibit qualities of endophenotypes, including substantial heritability, test-retest reliability, and trait-like stability. These measures also fulfill criteria for use as cognition and function-linked biomarkers in outcome studies, but have not yet been validated for use in large-scale multi-site clinical studies. This study tested the feasibility of adding MMN and P3a to the ongoing Consortium on the Genetics of Schizophrenia (COGS) study. The extent to which demographic, clinical, cognitive, and functional characteristics contribute to variability in MMN and P3a amplitudes was also examined. Participants (HCS n=824, SZ n=966) underwent testing at 5 geographically distributed COGS laboratories. Valid ERP recordings were obtained from 91% of HCS and 91% of SZ patients. Highly significant MMN (d=0.96) and P3a (d=0.93) amplitude reductions were observed in SZ patients, comparable in magnitude to those observed in single-lab studies with no appreciable differences across laboratories. Demographic characteristics accounted for 26% and 18% of the variance in MMN and P3a amplitudes, respectively. Significant relationships were observed among demographically adjusted MMN and P3a measures and medication status as well as several clinical, cognitive, and functional characteristics of the SZ patients. This study demonstrates that MMN and P3a ERP biomarkers can be feasibly used in multi-site clinical studies. As with many clinical tests of brain function, demographic factors contribute to MMN and P3a amplitudes and should be carefully considered in future biomarker-informed clinical studies. Published by Elsevier B.V. C1 [Light, Gregory A.; Swerdlowa, Neal R.; Thomas, Michael L.; Greenwood, Tiffany A.; Pela, Marlena; Sharp, Richard F.; Sprock, Joyce; Tsuang, Ming T.; Braff, David L.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA. [Light, Gregory A.] VA San Diego Healthcare Syst, VISN Mental Illness Res Educ & Clin Ctr MIRECC 22, San Diego, CA USA. [Calkins, Monica E.; Gur, Raquel E.; Gur, Ruben C.; Turetsky, Bruce I.] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA. [Green, Michael F.; Nuechterlein, Keith H.] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA USA. [Green, Michael F.] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. [Lazzeroni, Laura C.] Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA. [Radant, Allen D.; Tsuang, Debby W.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [Radant, Allen D.; Tsuang, Debby W.] VA Puget Sound Hlth Care Syst, Seattle, WA USA. [Seidman, Larry J.; Stone, William S.] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA. [Seidman, Larry J.; Stone, William S.] Beth Israel Deaconess Med Ctr, Massachusetts Mental Hlth Ctr, Publ Psychiat Div, Boston, MA 02215 USA. [Seidman, Larry J.; Sharp, Richard F.] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA. [Siever, Larry J.; Silverman, Jeremy M.] James J Peters VA Med Ctr, New York, NY USA. [Sugar, Catherine A.] Univ Calif Los Angeles, Sch Publ Hlth, Dept Biostat, Los Angeles, CA 90024 USA. [Tsuang, Ming T.] Univ Calif San Diego, Ctr Behav Genom, La Jolla, CA 92093 USA. [Tsuang, Ming T.] Univ Calif San Diego, Inst Genom Med, La Jolla, CA 92093 USA. [Tsuang, Ming T.] Harvard Inst Psychiat Epidemiol & Genet, Boston, MA USA. RP Light, GA (reprint author), 9500 Gilman Dr, La Jolla, CA 92093 USA. EM glight@ucsd.edu RI Tsuang, Debby/L-7234-2016 OI Tsuang, Debby/0000-0002-4716-1894; Lazzeroni, Laura/0000-0002-1846-6920; Greenwood, Tiffany/0000-0002-6080-6503 FU National Institute of Health FX Other than providing support, the National Institute of Health does not have any further role in this manuscript. NR 83 TC 19 Z9 19 U1 3 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0920-9964 EI 1573-2509 J9 SCHIZOPHR RES JI Schizophr. Res. PD APR PY 2015 VL 163 IS 1-3 BP 63 EP 72 DI 10.1016/j.schres.2014.09.042 PG 10 WC Psychiatry SC Psychiatry GA CE6EE UT WOS:000351928600009 PM 25449710 ER PT J AU Seidman, LJ Hellemann, G Nuechterlein, KH Greenwood, TA Braff, DL Cadenhead, KS Calkins, ME Freedman, R Gur, RE Gur, RC Lazzeroni, LC Light, GA Olincy, A Radant, AD Siever, LJ Silverman, JM Sprock, J Stone, WS Sugar, C Swerdlowe, NR Tsuang, DW Tsuang, MT Turetsky, BI Green, MF AF Seidman, Larry J. Hellemann, Gerhard Nuechterlein, Keith H. Greenwood, Tiffany A. Braff, David L. Cadenhead, Kristin S. Calkins, Monica E. Freedman, Robert Gur, Raquel E. Gur, Ruben C. Lazzeroni, Laura C. Light, Gregory A. Olincy, Ann Radant, Allen D. Siever, Larry J. Silverman, Jeremy M. Sprock, Joyce Stone, William S. Sugar, Catherine Swerdlowe, Neal R. Tsuang, Debby W. Tsuang, Ming T. Turetsky, Bruce I. Green, Michael F. TI Factor structure and heritability of endophenotypes in schizophrenia: Findings from the Consortium on the Genetics of Schizophrenia (COGS-1) SO SCHIZOPHRENIA RESEARCH LA English DT Article DE Schizophrenia; Endophenotype; Neurocognition; Neurophysiology; Genetics ID TRAIT LINKAGE ANALYSIS; PREPULSE INHIBITION; 1ST-DEGREE RELATIVES; ACOUSTIC STARTLE; P50 SUPPRESSION; WORKING-MEMORY; PERFORMANCE; PROBANDS; FAMILIES AB Background: Although many endophenotypes for schizophrenia have been studied individually, few studies have examined the extent to which common neurocognitive and neurophysiological measures reflect shared versus unique endophenotypic factors. It may be possible to distill individual endophenotypes into composite measures that reflect dissociable, genetically informative elements. Methods: The first phase of the Consortium on the Genetics of Schizophrenia (COGS-1) is a multisite family study that collected neurocognitive and neurophysiological data between 2003 and 2008. For these analyses, participants included schizophrenia probands (n = 83), their nonpsychotic siblings (n = 151), and community comparison subjects (n = 209) with complete data on a battery of 12 neurocognitive tests (assessing domains of working memory, declarative memory, vigilance, spatial ability, abstract reasoning, facial emotion processing, and motor speed) and 3 neurophysiological tasks reflecting inhibitory processing (P50 gating, prepulse inhibition and antisaccade tasks). Factor analyses were conducted on the measures for each subject group and across the entire sample. Heritability analyses of factors were performed using SOLAR. Results: Analyses yielded 5 distinct factors: 1) Episodic Memory, 2) Working Memory, 3) Perceptual Vigilance, 4) Visual Abstraction, and 5) Inhibitory Processing. Neurophysiological measures had low associations with these factors. The factor structure of endophenotypes was largely comparable across probands, siblings and controls. Significant heritability estimates for the factors ranged from 22% (Episodic Memory) to 39% (Visual Abstraction). Conclusions: Neurocognitive measures reflect a meaningful amount of shared variance whereas the neurophysiological measures reflect largely unique contributions as endophenotypes for schizophrenia. Composite endophenotype measures may inform our neurobiological and genetic understanding of schizophrenia. (C) 2015 Elsevier B.V. All rights reserved. C1 [Seidman, Larry J.; Stone, William S.] Harvard Univ, Sch Med, Massachusetts Mental Hlth Ctr, Publ Psychiat Div,Dept Psychiat, Boston, MA 02115 USA. [Seidman, Larry J.; Stone, William S.; Tsuang, Ming T.] Harvard Inst Psychiat Epidemiol & Genet s, Boston, MA USA. [Hellemann, Gerhard; Nuechterlein, Keith H.; Sugar, Catherine; Green, Michael F.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA. [Nuechterlein, Keith H.] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90024 USA. [Greenwood, Tiffany A.; Braff, David L.; Cadenhead, Kristin S.; Sprock, Joyce; Swerdlowe, Neal R.; Tsuang, Ming T.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA. [Braff, David L.; Light, Gregory A.] Mental Illness Res Educ & Clin Ctr MIRE, VA San Diego Healthcare Syst VISN 22, San Diego, CA USA. [Calkins, Monica E.; Gur, Raquel E.; Gur, Ruben C.; Turetsky, Bruce I.] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA. [Freedman, Robert; Olincy, Ann] Univ Colorado, Hlth Sci Ctr, Dept Psychiat, Denver, CO 80262 USA. [Lazzeroni, Laura C.] Stanford Univ, Med Ctr, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA. [Radant, Allen D.; Tsuang, Debby W.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [Radant, Allen D.; Tsuang, Debby W.] Mental Illness Res Educ & Clin Ctr, Dept Vet Affairs VISN 20, Seattle, WA USA. [Siever, Larry J.; Silverman, Jeremy M.] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA. [Siever, Larry J.] Mental Illness Res Educ & Clin Ctr, James J Peters VA & VISN3, Bronx, NY USA. [Sugar, Catherine] Univ Calif Los Angeles, Dept Biostat, Los Angeles, CA USA. [Sugar, Catherine; Green, Michael F.] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. [Tsuang, Ming T.] Univ Calif San Diego, Dept Psychiat, Ctr Behav Genom, La Jolla, CA 92093 USA. [Tsuang, Ming T.] Univ Calif San Diego, Inst Genom Med, La Jolla, CA 92093 USA. RP Seidman, LJ (reprint author), Commonwealth Res Ctr, Massachusetts Mental Hlth Ctr, Neuropsychol Lab, Room 542,75 Fenwood Rd, Boston, MA 02115 USA. EM lseidman@bidmc.harvard.edu; dbraff@ucsd.edu RI Tsuang, Debby/L-7234-2016 OI Tsuang, Debby/0000-0002-4716-1894; Lazzeroni, Laura/0000-0002-1846-6920; Greenwood, Tiffany/0000-0002-6080-6503 FU Harvard University [RO1-MH065562, MH43518]; Commonwealth Research Center of the Massachusetts Department of Mental Health; Mount Sinai School of Medicine [RO1-MH065554]; University of California Los Angeles [RO1-MH65707]; University of California San Diego [R01-MH065571]; University of Colorado [RO1-MH65588]; University of Pennsylvania [RO1-MH65578]; University of Washington [R01-MH65558] FX Harvard University RO1-MH065562; MH43518; Commonwealth Research Center of the Massachusetts Department of Mental Health; Mount Sinai School of Medicine RO1-MH065554; University of California Los Angeles RO1-MH65707); University of California San Diego R01-MH065571); University of Colorado RO1-MH65588; University of Pennsylvania RO1-MH65578; University of Washington R01-MH65558 NR 42 TC 16 Z9 16 U1 3 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0920-9964 EI 1573-2509 J9 SCHIZOPHR RES JI Schizophr. Res. PD APR PY 2015 VL 163 IS 1-3 BP 73 EP 79 DI 10.1016/j.schres.2015.01.027 PG 7 WC Psychiatry SC Psychiatry GA CE6EE UT WOS:000351928600010 PM 25682549 ER PT J AU Li, QY Berry, RB Goetting, MG Staley, B Soto-Calderon, H Tsai, SC Jasko, JG Pack, AI Kuna, ST AF Li, Qing Yun Berry, Richard B. Goetting, Mark G. Staley, Bethany Soto-Calderon, Haideliza Tsai, Sheila C. Jasko, Jeffrey G. Pack, Allan I. Kuna, Samuel T. TI Detection of Upper Airway Status and Respiratory Events by a Current Generation Positive Airway Pressure Device SO SLEEP LA English DT Article DE central sleep apnea; obstructive sleep apnea; positive airway pressure; respiratory event related arousal; upper airway ID APNEA-HYPOPNEA SYNDROME; CENTRAL SLEEP-APNEA; CPAP; POLYSOMNOGRAPHY; ACCURACY; ADULTS; INDEX AB Study Objectives: To compare a positive airway pressure (PAP) device's detection of respiratory events and airway status during device-detected apneas with events scored on simultaneous polysomnography (PSG). Design: Prospective PSGs of patients with sleep apnea using a new-generation PAP device. Settings: Four clinical and academic sleep centers. Patients: Forty-five patients with obstructive sleep apnea (OSA) and complex sleep apnea (Comp SA) performed a PSG on PAP levels adjusted to induce respiratory events. Interventions: None. Measurements and Results: PAP device data identifying the type of respiratory event and whether the airway during a device-detected apnea was open or obstructed were compared to time-synced, manually scored respiratory events on simultaneous PSG recording. Intraclass correlation coefficients between device-detected and PSG scored events were 0.854 for apnea-hypopnea index (AHI), 0.783 for apnea index, 0.252 for hypopnea index, and 0.098 for respiratory event-related arousals index. At a device AHI (AHI(Flow))of 10 events/h, area under the receiver operating characteristic curve was 0.98, with sensitivity 0.92 and specificity 0.84. AHI(Flow) tended to overestimate AHI on PSG at values less than 10 events/h. The device detected that the airway was obstructed in 87.4% of manually scored obstructive apneas. Of the device-detected apneas with clear airway, a minority (15.8%) were manually scored as obstructive apneas. Conclusions: A device-detected apnea-hypopnea index (AHI(Flow)) <10 events/h on a positive airway pressure device is strong evidence of good treatment efficacy. Device-detected airway status agrees closely with the presumed airway status during polysomnography scored events, but should not be equated with a specific type of respiratory event. C1 [Li, Qing Yun] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Resp Med, Shanghai 200025, Peoples R China. [Li, Qing Yun; Staley, Bethany; Soto-Calderon, Haideliza; Pack, Allan I.; Kuna, Samuel T.] Univ Penn, Dept Med, Perelman Sch Med, Philadelphia, PA 19104 USA. [Berry, Richard B.] Univ Florida, Dept Med, Gainesville, FL USA. [Goetting, Mark G.] Bronson Sleep Hlth, Kalamazoo, MI USA. [Tsai, Sheila C.] Natl Jewish Hlth, Dept Med, Denver, CO USA. [Jasko, Jeffrey G.] Philips Respiron Inc, Monroeville, PA USA. [Kuna, Samuel T.] Philadelphia Vet Affairs Med Ctr, Dept Med, Philadelphia, PA USA. RP Li, QY (reprint author), Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Resp Med, 197 Ruijin Er Rd, Shanghai 200025, Peoples R China. EM liqingyun68@hotmail.com FU NIH [1P01-1HL094307]; Philips Respironics, Inc. FX This study was supported by NIH 1P01-1HL094307 and Philips Respironics, Inc. Mr. Jasko is employed by Philips Respironics. The other authors have indicated no conflicts of interest. NR 14 TC 1 Z9 1 U1 0 U2 9 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 EI 1550-9109 J9 SLEEP JI Sleep PD APR 1 PY 2015 VL 38 IS 4 DI 10.5665/sleep.4578 PG 9 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA CE7CC UT WOS:000351993600010 ER PT J AU Boyers, LN Schultz, A Baceviciene, R Blaney, S Marvi, N Dellavalle, RP Dunnick, CA AF Boyers, Lindsay N. Schultz, Amanda Baceviciene, Rasa Blaney, Susan Marvi, Natasha Dellavalle, Robert P. Dunnick, Cory A. TI Teledermatology as an Educational Tool for Teaching Dermatology to Residents and Medical Students SO TELEMEDICINE AND E-HEALTH LA English DT Article DE education; teledermatology; telemedicine; dermatology AB Although teledermatology (TD) is regarded as a tool to improve patient access to specialty healthcare, little has been done to evaluate its role in medical education. We describe the TD program at the Denver (CO) Department of Veterans Affairs Medical Center and evaluate its use as an educational tool for teaching dermatology to dermatology residents and medical students. Dermatology residents manage TD consultations and review all cases with a faculty preceptor; medical students participate as observers when possible. This study assessed dermatology resident (n=14) and medical student (n=16) perceptions of TD and its usefulness in teaching six core clinical competencies. Both residents (79%) and medical students (88%) "strongly agree" or "agree" that TD is an important educational tool. In general, medical students were slightly more satisfied than residents across all of the core competencies assessed except for patient care. Medical students and residents were most satisfied with the competencies of practice-based learning and improvement and medical knowledge, whereas they were least satisfied with those of interpersonal and communication skills and professionalism. Overall, TD is valued as a teaching tool for dermatology in the areas of patient care, medical knowledge, practice-based learning and improvement, and systems-based practice. C1 [Boyers, Lindsay N.] Georgetown Univ, Sch Med, Washington, DC USA. [Schultz, Amanda; Dellavalle, Robert P.; Dunnick, Cory A.] Eastern Colorado Hlth Care Syst, Dermatol Serv, US Dept Vet Affairs, Denver, CO USA. [Baceviciene, Rasa; Marvi, Natasha] Univ Colorado, Sch Med, Aurora, CO USA. [Blaney, Susan] Rocky Mt Network, Vet Integrated Serv Network 19, Telehlth Program, Denver, CO USA. [Dellavalle, Robert P.; Dunnick, Cory A.] Univ Colorado Anschutz Med Campus, Dept Dermatol, Aurora, CO USA. [Dellavalle, Robert P.] Univ Colorado Anschutz Med Campus, Colorado Sch Publ Hlth, Dept Epidemiol, Aurora, CO USA. RP Dunnick, CA (reprint author), Univ Colorado Denver, Dept Dermatol, 1665 Aurora Court,MS 703, Aurora, CO 80045 USA. EM cory.dunnick@ucdenver.edu FU Centers for Disease Control and Prevention; National Institutes of Health FX L.N.B., A.S., S.B., R.P.D., and C.A.D. were employed by the U.S. Department of Veterans Affairs during the preparation of this manuscript. R.P.D. chairs the Colorado Skin Cancer Prevention Task Force and is supported by grants from the Centers for Disease Control and Prevention and the National Institutes of Health. R.B. and N.M. declare no competing financial interests exist. NR 11 TC 3 Z9 3 U1 1 U2 2 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-5627 EI 1556-3669 J9 TELEMED E-HEALTH JI Telemed. e-Health PD APR 1 PY 2015 VL 21 IS 4 BP 312 EP 314 DI 10.1089/tmj.2014.0101 PG 3 WC Health Care Sciences & Services SC Health Care Sciences & Services GA CF1DT UT WOS:000352284600012 PM 25635528 ER PT J AU Ma, RS Latif, R Davies, TF AF Ma, Risheng Latif, Rauf Davies, Terry F. TI Human Embryonic Stem Cells Form Functional Thyroid Follicles SO THYROID LA English DT Article ID TRANSGENE EXPRESSION; FOLLICULAR CELLS; GENE-TRANSFER; DIFFERENTIATION; REQUIRES; PROTEIN; LUNG; PAX8 AB Objective: The molecular events that lead to human thyroid cell speciation remain incompletely characterized. It has been shown that overexpression of the regulatory transcription factors Pax8 and Nkx2-1 (ttf-1) directs murine embryonic stem (mES) cells to differentiate into thyroid follicular cells by initiating a transcriptional regulatory network. Such cells subsequently organized into three-dimensional follicular structures in the presence of extracellular matrix. In the current study, human embryonic stem (hES) cells were studied with the aim of recapitulating this scenario and producing functional human thyroid cell lines. Methods: Reporter gene tagged pEZ-lentiviral vectors were used to express human PAX8-eGFP and NKX2-1-mCherry in the H9 hES cell line followed by differentiation into thyroid cells directed by Activin A and thyrotropin (TSH). Results: Both transcription factors were expressed efficiently in hES cells expressing either PAX8, NKX2-1, or in combination in the hES cells, which had low endogenous expression of these transcription factors. Further differentiation of the double transfected cells showed the expression of thyroid-specific genes, including thyroglobulin (TG), thyroid peroxidase (TPO), the sodium/iodide symporter (NIS), and the TSH receptor (TSHR) as assessed by reverse transcription polymerase chain reaction and immunostaining. Most notably, the Activin/TSH-induced differentiation approach resulted in thyroid follicle formation and abundant TG protein expression within the follicular lumens. On stimulation with TSH, these hES-derived follicles were also capable of dose-dependent cAMP generation and radioiodine uptake, indicating functional thyroid epithelial cells. Conclusion: The induced expression of PAX8 and NKX2-1 in hES cells was followed by differentiation into thyroid epithelial cells and their commitment to form functional three-dimensional neo-follicular structures. The data provide proof of principal that hES cells can be committed to thyroid cell speciation under appropriate conditions. C1 Icahn Sch Med Mt Sinai, Thyroid Res Unit, Dept Med, New York, NY 10029 USA. James J Peters VA Med Ctr, New York, NY USA. RP Ma, RS (reprint author), VA Med Ctr, Room 2F-27,130 West Kingsbridge Rd, New York, NY 10468 USA. EM risheng.ma@mssm.edu OI latif, rauf/0000-0002-4226-3728 FU National Institutes of Health [DK069713]; VA Merit Review Program FX Supported in part by DK069713 from the National Institutes of Health and the VA Merit Review Program. NR 19 TC 9 Z9 9 U1 1 U2 6 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1050-7256 EI 1557-9077 J9 THYROID JI Thyroid PD APR 1 PY 2015 VL 25 IS 4 BP 455 EP 461 DI 10.1089/thy.2014.0537 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA CF1HJ UT WOS:000352295100011 PM 25585054 ER PT J AU Saxon, AJ AF Saxon, Andrew J. TI Commentary on Burns et al. (2015): Retention in buprenorphine treatment SO ADDICTION LA English DT Editorial Material DE Buprenorphine; medication assisted treatment; methadone; opioid use disorder; pharmacogenetics; treatment retention ID PRESCRIPTION OPIOID DEPENDENCE; MAINTENANCE THERAPY; METHADONE; TRIAL; MULTISITE; OPRD1 C1 Univ Washington, Dept Psychiat & Behav Sci, Addict Psychiat Residency Program, CESATE,VA Puget Sound Hlth Care Syst, Seattle, WA 98108 USA. RP Saxon, AJ (reprint author), Univ Washington, Dept Psychiat & Behav Sci, Addict Psychiat Residency Program, CESATE,VA Puget Sound Hlth Care Syst, 1660 South Columbian Way, Seattle, WA 98108 USA. EM asaxon@uw.edu FU Janssen FX Andrew J. Saxon has received honoraria or worked as a consultant for Alkermes, Inc. and ReckittBenckiser, Inc. and has received research support from Janssen. Alkermes and ReckittBenckiser have supplied study medications for several clinical trials on which Andrew J. Saxon has been an investigator. Andrew J. Saxon also serves as a section editor for UpToDate for which he has received royalties. NR 17 TC 0 Z9 0 U1 1 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0965-2140 EI 1360-0443 J9 ADDICTION JI Addiction PD APR PY 2015 VL 110 IS 4 BP 656 EP 657 DI 10.1111/add.12865 PG 2 WC Substance Abuse; Psychiatry SC Substance Abuse; Psychiatry GA CD6PK UT WOS:000351211200015 PM 25771691 ER PT J AU Levy, CE Halan, S Silverman, EP Marsiske, M Lehman, L Omura, D Lok, BC AF Levy, Charles E. Halan, Shivashankar Silverman, Erin P. Marsiske, Michael Lehman, Leigh Omura, David Lok, Benjamin C. TI Virtual Environments and Virtual Humans for Military Mild Traumatic Brain Injury and Posttraumatic Stress Disorder: An Emerging Concept SO AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION LA English DT Article C1 [Levy, Charles E.; Silverman, Erin P.; Lehman, Leigh] North Florida South Georgia Vet Hlth Syst, US Dept Vet Affairs, Gainesville, FL USA. [Levy, Charles E.] Univ Florida, Dept Occupat Therapy, Gainesville, FL 32610 USA. [Halan, Shivashankar; Lok, Benjamin C.] Univ Florida, Dept Comp & Informat Sci & Engn, Coll Engn, Gainesville, FL 32610 USA. [Silverman, Erin P.] Univ Florida, Coll Vet Med, Dept Physiol Sci, Gainesville, FL 32610 USA. [Marsiske, Michael] Univ Florida, Dept Clin & Hlth Psychol, Coll Publ Hlth & Hlth Profess, Gainesville, FL 32610 USA. [Lehman, Leigh] Univ Florida, Dept Occupat Therapy, Coll Publ Hlth & Hlth Profess, Gainesville, FL 32610 USA. [Omura, David] US Dept Vet Affairs, Charlotte, NC USA. RP Silverman, EP (reprint author), Univ Florida, Coll Vet Med, Dept Physiol Sci, POB 100144, Gainesville, FL 32610 USA. OI Marsiske, Michael/0000-0001-5973-2116 FU [W81XWH-08-2-0194 PT073664]; [CDMRP/DoD 9.15.08-9.14.09]; [1I01RX000339-01A3] FX Supported by (1) W81XWH-08-2-0194 PT073664 Design of Effective Therapeutic Interventions for Mild TBI/PTSD using Interactive Virtual World Environments, CDMRP/DoD 9.15.08-9.14.09; (2) Development of Virtual Humans For PTSD and mTBI: Rehabilitation Outcomes Research Center 2010-2011; and (3) 1I01RX000339-01A3, Virtual Environments for Therapuetic Solutions (VETS) mTBI/PTSD Phase II, VA RR&D, $824,835, 4.1.13-3.30.16. NR 2 TC 0 Z9 1 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0894-9115 EI 1537-7385 J9 AM J PHYS MED REHAB JI Am. J. Phys. Med. Rehabil. PD APR PY 2015 VL 94 IS 4 BP E31 EP E32 DI 10.1097/PHM.0000000000000248 PG 2 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA CE1BQ UT WOS:000351547000002 PM 25741622 ER PT J AU Cavusoglu, E Marmur, JD Chhabra, S Hojjati, MR Yanamadala, S Chopra, V Eng, C Jiang, XC AF Cavusoglu, Erdal Marmur, Jonathan D. Chhabra, Sandeep Hojjati, Mohammad R. Yanamadala, Sunitha Chopra, Vineet Eng, Calvin Jiang, Xian-Cheng TI Elevated baseline plasma phospholipid protein (PLTP) levels are an independent predictor of long-term all-cause mortality in patients with diabetes mellitus and known or suspected coronary artery disease SO ATHEROSCLEROSIS LA English DT Article DE PLTP; Phospholipid transfer protein; Biomarkers; Acute coronary syndrome; Prognosis; Mortality; Diabetes mellitus; Atherosclerosis; Myocardial infarction ID APOLIPOPROTEIN-B; LIPOPROTEIN METABOLISM; INSULIN-RESISTANCE; RISK-FACTOR; VITAMIN-E; ATHEROSCLEROSIS; DETERMINANT; DEFICIENCY; MICE; HDL AB Objectives: To investigate the long-term prognostic significance of baseline plasma PLTP levels in a group of well-characterized male patients with diabetes mellitus and known or suspected coronary artery disease referred for coronary angiography. Background: PLTP is a plasma protein that mediates the net transfer and exchange of phospholipids between lipoproteins. It has been implicated in the pathogenesis of atherosclerosis and elevated plasma levels have been reported in patients with diabetes mellitus. Methods: Baseline plasma PLTP levels were measured in 154 male patients with diabetes mellitus who were referred for coronary angiography and followed prospectively for 5 years for the development of all-cause mortality. Results: After adjustment for a variety of baseline clinical, angiographic and laboratory parameters, plasma PLTP levels (analyzed as a continuous variable) were an independent predictor of all-cause mortality at 5 years (HR, 1.55; 95% CI, 1.22-2.00; P = 0.0009). Furthermore, in 3 additional multivariate models that also included a wide variety of contemporary biomarkers with established prognostic efficacy (i.e., ST2, GDF-15, Cystatin C, Fibrinogen, and NT-proBNP), PLTP remained an independent predictor of all-cause mortality at 5 years. Conclusions: Elevated baseline plasma levels of PLTP are associated with an increased risk of long-term all-cause mortality in patients with diabetes and known or suspected coronary disease. Furthermore, this association is independent of a variety of clinical, angiographic, and laboratory variables, including a whole host of contemporary biomarkers with established prognostic efficacy. (C) 2015 Elsevier Ireland Ltd. All rights reserved. C1 [Cavusoglu, Erdal; Chopra, Vineet; Eng, Calvin] Bronx Vet Affairs Med Ctr, Dept Med, Div Cardiol, Bronx, NY USA. [Cavusoglu, Erdal; Marmur, Jonathan D.; Chhabra, Sandeep; Hojjati, Mohammad R.; Yanamadala, Sunitha] Suny Downstate Med Ctr, Dept Med, Div Cardiol, Brooklyn, NY 11203 USA. [Jiang, Xian-Cheng] Suny Downstate Med Ctr, Dept Anat & Cell Biol, Brooklyn, NY 11203 USA. RP Cavusoglu, E (reprint author), Suny Downstate Med Ctr, 450 Clarkson Ave,Box 1199, Brooklyn, NY 11203 USA. EM ECavusoglu@aol.com FU American Heart Association [10GRNT3700003]; NIH-NHLBI [5R21HL098661-02] FX This study was sponsored, in part, by grants related to biomarkers from the American Heart Association (Grant-in-Aid 10GRNT3700003) and the NIH-NHLBI (5R21HL098661-02). NR 32 TC 4 Z9 6 U1 0 U2 0 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0021-9150 EI 1879-1484 J9 ATHEROSCLEROSIS JI Atherosclerosis PD APR PY 2015 VL 239 IS 2 BP 503 EP 508 DI 10.1016/j.atherosclerosis.2015.02.017 PG 6 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA CD4NZ UT WOS:000351061600032 PM 25710294 ER PT J AU Malhotra, R Turner, K Sonnenberg, A Genta, RM AF Malhotra, Reenu Turner, Kevin Sonnenberg, Amnon Genta, Robert M. TI High Prevalence of Inflammatory Bowel Disease in United States Residents of Indian Ancestry SO CLINICAL GASTROENTEROLOGY AND HEPATOLOGY LA English DT Article DE Ethnic Studies; Indian Immigrants; Lifestyle; Western; Latino ID REGIONAL DIFFERENCES; BARRETTS-ESOPHAGUS; POPULATION; EPIDEMIOLOGY; MANAGEMENT; RISK AB BACKGROUND & AIMS: It is unclear whether the reported low prevalence of inflammatory bowel disease (IBD) in Southern and Eastern Asia is real (caused by genetic or environmental factors) or spurious (because of differences in awareness of the condition among physicians or different interpretations of endoscopic and histologic features). We aimed to estimate the prevalence of IBD in patients of different ethnicities who underwent endoscopy in the United States, with ileocolonic biopsies evaluated by a single group of gastrointestinal pathologists. METHODS: We used a national pathology database to collect data on 1,027,977 subjects who underwent colonoscopy with ileocolonic biopsies from January 2008 through December 2013 throughout the United States; mucosal biopsy specimens were evaluated and reported by 1 group of 35 histopathologists. Patients were stratified into the following ancestries: Indian (persons with ancestry in the Indian subcontinent), East Asian (China, Korea, Japan, and Vietnam), Hispanic, Jewish, and Other. The prevalence of ulcerative colitis (UC), Crohn's disease (CD), and indeterminate colitis was determined for each ethnic group. RESULTS: In the study population, 30,812 patients were diagnosed with IBD (20,308 with UC, 7706 with CD, and 2798 with indeterminate colitis). UC was more commonly associated with Indian and Jewish ethnicity and less commonly associated with East Asian and Hispanic ethnicity. Similar patterns also applied to CD and to all types of IBD analyzed jointly. Among Indian patients, 11.7% of those of Gujarati origins had IBD, compared with 7.9% of other Indians (odds ratio, 1.5; 95% confidence interval, 1.14-2.11). CONCLUSIONS: Patients of Indian origin living in the United States have a greater risk for all types of IBD than other American populations. East Asians and Hispanics have a lower risk, possibly similar to that of the populations still living in their original countries. These findings may have relevance to the practice of gastroenterology in countries where there are sizable portions of the population with roots in the Indian subcontinent. C1 [Malhotra, Reenu; Turner, Kevin; Genta, Robert M.] Miraca Life Sci, Res Inst, Irving, TX 75039 USA. [Sonnenberg, Amnon] Portland VA Med Ctr, Portland, OR USA. [Sonnenberg, Amnon] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [Genta, Robert M.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA. [Genta, Robert M.] Dallas VA Med Ctr, Dallas, TX USA. RP Genta, RM (reprint author), Miraca Life Sci, 6655 North MacArthur Blvd, Irving, TX 75039 USA. EM robert.genta@utsouthwestern.edu NR 22 TC 8 Z9 8 U1 0 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1542-3565 EI 1542-7714 J9 CLIN GASTROENTEROL H JI Clin. Gastroenterol. Hepatol. PD APR PY 2015 VL 13 IS 4 BP 683 EP 689 DI 10.1016/j.cgh.2014.06.035 PG 7 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA CD7UL UT WOS:000351299300014 PM 25083563 ER PT J AU Thorpe, CT Gellad, WF Good, CB Zhang, SJ Zhao, XH Mor, M Fine, MJ AF Thorpe, Carolyn T. Gellad, Walid F. Good, Chester B. Zhang, Sijian Zhao, Xinhua Mor, Maria Fine, Michael J. TI Tight Glycemic Control and Use of Hypoglycemic Medications in Older Veterans With Type 2 Diabetes and Comorbid Dementia SO DIABETES CARE LA English DT Article ID ADMINISTRATIVE DATA; MELLITUS; COHORT; ADULTS; SURVIVAL; RISK; OVERTREATMENT; PREVALENCE; DIAGNOSIS; DISEASE AB OBJECTIVEOlder adults with diabetes and dementia are at increased risk for hypoglycemia and other adverse events associated with tight glycemic control and are unlikely to experience long-term benefits. We examined risk factors for tight glycemic control in this population and use of medications associated with a high risk of hypoglycemia in the subset with tight control.RESEARCH DESIGN AND METHODSThis retrospective cohort study of national Veterans Affairs (VA) administrative/clinical data and Medicare claims for fiscal years (FYs) 2008-2009 included 15,880 veterans aged 65 years with type 2 diabetes and dementia and prescribed antidiabetic medication. Multivariable regression analyses were used to identify sociodemographic and clinical predictors of hemoglobin A(1c) (HbA(1c)) control (tight, moderate, poor, or not monitored) and, in patients with tight control, subsequent use of medication associated with a high risk of hypoglycemia (sulfonylureas, insulin).RESULTSFifty-two percent of patients had tight glycemic control (HbA(1c) <7% [53 mmol/mol]). Specific comorbidities, older age, and recent weight loss were associated with greater odds of tight versus moderate control, whereas Hispanic ethnicity and obesity were associated with lower odds of tight control. Among tightly controlled patients, 75% used sulfonylureas and/or insulin, with higher odds in patients who were male, black, or aged 75 years; had a hospital or nursing home stay in FY2008; or had congestive heart failure, renal failure, or peripheral vascular disease.CONCLUSIONSMany older veterans with diabetes and dementia are at high risk for hypoglycemia associated with intense diabetes treatment and may be candidates for deintensification or alteration of diabetes medications. C1 [Thorpe, Carolyn T.; Gellad, Walid F.; Good, Chester B.; Zhang, Sijian; Zhao, Xinhua; Mor, Maria; Fine, Michael J.] Vet Affairs Pittsburgh Healthcare Syst, Ctr Hlth Equ Res & Promot, Pittsburgh, PA 15240 USA. [Thorpe, Carolyn T.; Good, Chester B.] Univ Pittsburgh, Sch Pharm, Dept Pharm & Therapeut, Pittsburgh, PA 15261 USA. [Gellad, Walid F.; Good, Chester B.; Fine, Michael J.] Univ Pittsburgh, Sch Med, Div Gen Internal Med, Pittsburgh, PA USA. [Good, Chester B.; Zhao, Xinhua] Vet Affairs Pharm Benefits Management, Chicago, IL USA. [Mor, Maria] Univ Pittsburgh, Sch Publ Hlth, Dept Biostat, Pittsburgh, PA 15260 USA. RP Thorpe, CT (reprint author), Vet Affairs Pittsburgh Healthcare Syst, Ctr Hlth Equ Res & Promot, Pittsburgh, PA 15240 USA. EM ctthorpe@pitt.edu FU VA Health Services Research Development [CIN 13-405]; VA Health Services Research & Development Career Development Award [CDA 09-207] FX C.T.T., S.Z., M.M., and M.J.F. are supported by VA Health Services Research & Development (CIN 13-405). W.F.G. is supported by a VA Health Services Research & Development Career Development Award (CDA 09-207). NR 32 TC 9 Z9 9 U1 2 U2 5 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA SN 0149-5992 EI 1935-5548 J9 DIABETES CARE JI Diabetes Care PD APR PY 2015 VL 38 IS 4 BP 588 EP 595 DI 10.2337/dc14-0599 PG 8 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA CE2FX UT WOS:000351630900020 PM 25592195 ER PT J AU Guerrero-Berroa, E Ravona-Springer, R Heymann, A Schmeidler, J Levy, A Leroith, D Beeri, MS AF Guerrero-Berroa, Elizabeth Ravona-Springer, Ramit Heymann, Anthony Schmeidler, James Levy, Andrew Leroith, Derek Beeri, Michal S. TI Haptoglobin genotype modulates the relationships of glycaemic control with cognitive function in elderly individuals with type 2 diabetes SO DIABETOLOGIA LA English DT Article DE Cognition; Cognitive domains; Diabetes; Glucose; Glycaemia; Haptoglobin; HbA(1c) ID SMALL VESSEL DISEASE; ALZHEIMERS-DISEASE; CARDIOVASCULAR-DISEASE; NEUROPSYCHOLOGICAL BATTERY; HBA(1C) VARIABILITY; GLOBAL PREVALENCE; PROCESSING SPEED; OLDER-ADULTS; DEMENTIA; RISK AB The purpose of this study was to investigate whether the association of glycaemic control with cognitive function is modulated by the haptoglobin 1-1 (Hp 1-1) genotype in cognitively normal elderly individuals with type 2 diabetes. In this cross-sectional study, we examined 793 participants who were genotyped for Hp (80 Hp 1-1 carriers and 713 Hp 1-1 non-carriers) enrolled in the Israel Diabetes and Cognitive Decline (IDCD) study. Glycaemic control was operationally defined by HbA(1c) level. The outcome measures were performance in four cognitive domains (episodic memory, attention/working memory, language/semantic categorisation, executive function) and overall cognition, a composite of the domains. Effect sizes were obtained from hierarchical linear regression analyses for each outcome measure, controlling for demographics, type 2 diabetes-related characteristics, cardiovascular risk factors, and their interactions with Hp genotype. Interaction analyses showed significantly stronger associations of HbA(1c) with poorer cognitive function among Hp 1-1 carriers than non-carriers; attention/working memory (p < 0.001) and overall cognition (p = 0.003). For these two cognitive domains, associations were significant for Hp 1-1 carriers despite the small sample size (p < 0.00001 and p = 0.001, respectively), but not for non-carriers. Our findings suggest that patients with type 2 diabetes and poor glycaemic control carrying the Hp 1-1 genotype may be at increased risk of cognitive impairment, particularly in the attention/working memory domain. The association of glycaemic control with this domain may indicate cerebrovascular mechanisms. C1 [Guerrero-Berroa, Elizabeth; Schmeidler, James; Beeri, Michal S.] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA. [Guerrero-Berroa, Elizabeth] James J Peters VA Med Ctr, Bronx, NY 10468 USA. [Ravona-Springer, Ramit; Beeri, Michal S.] Chaim Sheba Med Ctr, Joseph Sagol Neurosci Ctr, Ramat Gan, Israel. [Ravona-Springer, Ramit; Heymann, Anthony] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel. [Heymann, Anthony] Maccabi Healthcare Serv, Tel Aviv, Israel. [Levy, Andrew] Technion Israel Inst Technol, Technion Fac Med, Haifa, Israel. [Leroith, Derek] Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA. [Beeri, Michal S.] Interdisciplinary Ctr, Sch Psychol, Hertzlia, Israel. RP Guerrero-Berroa, E (reprint author), James J Peters VA Med Ctr, 130 West Kingsbridge Rd,Room 1F-01, Bronx, NY 10468 USA. EM elizabeth.guerrero-berroa@mssm.edu FU NIA NIH HHS [R01 AG034087, P50 AG005138] NR 52 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0012-186X EI 1432-0428 J9 DIABETOLOGIA JI Diabetologia PD APR PY 2015 VL 58 IS 4 BP 736 EP 744 DI 10.1007/s00125-014-3487-2 PG 9 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA CD2BK UT WOS:000350878400013 PM 25628235 ER PT J AU Chirinos, DA Medina-Lezama, J Salinas-Najarro, B Arguelles, W Llabre, MM Schneiderman, N Paz-Manrique, R Bolanos, JF Khan, Z Chirinos, JA AF Chirinos, Diana A. Medina-Lezama, Josefina Salinas-Najarro, Belissa Arguelles, William Llabre, Maria M. Schneiderman, Neil Paz-Manrique, Roberto Bolanos, Juan F. Khan, Zubair Chirinos, Julio A. TI Depressive symptoms and carotid intima-media thickness in South American Hispanics: results from the PREVENCION study SO JOURNAL OF BEHAVIORAL MEDICINE LA English DT Article DE Depression; Carotid intima-media thickness; Gender moderation; South American Hispanics; Cardiovascular disease ID CORONARY-ARTERY-DISEASE; HEART-RATE-VARIABILITY; C-REACTIVE PROTEIN; 1966 BIRTH COHORT; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; MYOCARDIAL-INFARCTION; RISK-FACTORS; SUBCLINICAL ATHEROSCLEROSIS; HOSPITAL ANXIETY AB This study aimed to: (1) examine the relationship between depressive symptoms and subclinical atherosclerosis, measured by carotid intima-media thickness (IMT); and, (2) Determine the moderating effect of gender in this relationship among South American Hispanics. We studied 496 adults enrolled in the population-based PREVENCION study. Carotid IMT was measured with high-resolution ultrasonography. Depressive symptoms were assessed using the Hospital Anxiety and Depression Scale. Mean carotid IMT was 0.66 mm. (SD = 0.17) and mean depression score was 5.6 (SD = 3.5). Depressive symptoms were not associated with carotid IMT (beta = 0.04, p = 0.222) in multivariate analyses. A significant moderating effect of gender was found (beta for interaction = 0.10, p = 0.030), resulting from a significant association between depressive symptoms and carotid IMT in men but not women. Depressive symptoms were associated with subclinical atherosclerosis in South American Hispanic men but not women after controlling for demographic characteristics and traditional cardiovascular risk factors. C1 [Chirinos, Diana A.; Arguelles, William; Llabre, Maria M.; Schneiderman, Neil] Univ Miami, Dept Psychol, Coral Gables, FL 33124 USA. [Chirinos, Diana A.; Medina-Lezama, Josefina; Salinas-Najarro, Belissa; Paz-Manrique, Roberto; Bolanos, Juan F.] Santa Maria Catholic Univ, Res Inst, Arequipa, Peru. [Khan, Zubair; Chirinos, Julio A.] Univ Penn, Philadelphia, PA 19104 USA. [Chirinos, Julio A.] Philadelphia VA Med Ctr, Philadelphia, PA USA. RP Chirinos, DA (reprint author), Univ Miami, Dept Psychol, POB 248185, Coral Gables, FL 33124 USA. EM dchirinos-medina@psy.miami.edu OI Khan, Zubair/0000-0002-0451-9155 FU Santa Maria Research Institute in Arequipa, Peru FX The PREVENCION study was supported by the Santa Maria Research Institute in Arequipa, Peru. NR 60 TC 2 Z9 2 U1 0 U2 3 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0160-7715 EI 1573-3521 J9 J BEHAV MED JI J. Behav. Med. PD APR PY 2015 VL 38 IS 2 BP 284 EP 293 DI 10.1007/s10865-014-9599-9 PG 10 WC Psychology, Clinical SC Psychology GA CD5NV UT WOS:000351135900010 PM 25267357 ER PT J AU Mayberry, LS Egede, LE Wagner, JA Osborn, CY AF Mayberry, Lindsay Satterwhite Egede, Leonard E. Wagner, Julie A. Osborn, Chandra Y. TI Stress, depression and medication nonadherence in diabetes: test of the exacerbating and buffering effects of family support SO JOURNAL OF BEHAVIORAL MEDICINE LA English DT Article DE Stress/stressors; Depression; Family support; Social support; Medication adherence; Diabetes ID SOCIAL SUPPORT; GLYCEMIC CONTROL; SUPPRESSOR VARIABLES; REGIMEN ADHERENCE; PATIENT-ADHERENCE; PHARMACY RECORDS; HEALTH LITERACY; SELF-CARE; ADULTS; MORTALITY AB Stressors and depressive symptoms have been associated with medication nonadherence among adults with type 2 diabetes (T2DM). We tested whether these associations were exacerbated by obstructive family behaviors or buffered by supportive family behaviors in a sample of 192 adults with T2DM and low socioeconomic status using unadjusted and adjusted regression models. We found support for the exacerbating hypothesis. Stressors and nonadherence were only associated at higher levels of obstructive family behaviors (interaction AOR = 1.12, p = .002). Similarly, depressive symptoms and nonadherence were only associated at higher levels of obstructive family behaviors (interaction AOR = 3.31, p = .002). When participants reported few obstructive family behaviors, neither stressors nor depressive symptoms were associated with nonadherence. We did not find support for the buffering hypothesis; stressors and depressive symptoms were associated with nonadherence regardless of supportive family behaviors. Nonadherent patients experiencing stressors and/or major depressive symptoms may benefit from interventions that reduce obstructive family behaviors. C1 [Mayberry, Lindsay Satterwhite; Osborn, Chandra Y.] Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN 37235 USA. [Mayberry, Lindsay Satterwhite; Osborn, Chandra Y.] Vanderbilt Univ, Med Ctr, Ctr Diabet Translat Res, Nashville, TN USA. [Mayberry, Lindsay Satterwhite; Osborn, Chandra Y.] Vanderbilt Univ, Med Ctr, Ctr Hlth Behav & Hlth Educ, Nashville, TN USA. [Egede, Leonard E.] Ralph H Johnson Dept Vet Affairs Med Ctr, Hlth Equ & Rural Outreach Innovat Ctr, Charleston, SC USA. [Egede, Leonard E.] Med Univ S Carolina, Ctr Hlth Dispar Res, Div Gen Internal Med, Charleston, SC 29425 USA. [Wagner, Julie A.] Univ Connecticut, Ctr Hlth, Div Behav Sci & Community Hlth, Farmington, CT USA. [Osborn, Chandra Y.] Vanderbilt Univ, Med Ctr, Dept Biomed Informat, Nashville, TN USA. RP Mayberry, LS (reprint author), Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN 37235 USA. EM Lindsay.mayberry@vanderbilt.edu FU National Center for Research Resources at the National Center for Advancing Translational Sciences [UL1 RR024975-01, 2 UL1 TR000445-06]; NIH/NIDDK Career Development Award [K01DK087894]; NIH/NIDDK National Research Service Award [F32DK097880]; AHRQ [K12 HS022990]; NIH/NIMHD [R01 MD005879]; NIH/NIDDK [DP3 DK097705, K24DK093699, R01DK098529]; American Diabetes Association [7-13-TS-31]; Chicago Center for Diabetes Translation Research; [P30DK092986]; [R01 (R01DK100694-01A1)] FX The authors would like to acknowledge Cecilia C. Quintero, Sahbina Ebba, Karen Calderon, Leo Cortes, Anne Crook, Carmen Mekhail, the Vine Hill Community Clinic personnel, and the participants for their contributions to this research. This research study was funded with support the National Center for Research Resources, Grant UL1 RR024975-01, which is now at the National Center for Advancing Translational Sciences, Grant 2 UL1 TR000445-06. This study was supported in part by grant P30DK092986 (PI: Elasy). C. Y. O. was supported by an NIH/NIDDK Career Development Award (K01DK087894) and R01 (R01DK100694-01A1). L. S. M. was supported by an NIH/NIDDK National Research Service Award (F32DK097880) and AHRQ (K12 HS022990). J. A. W. was supported by the NIH/NIMHD (R01 MD005879), the NIH/NIDDK (DP3 DK097705), the American Diabetes Association (7-13-TS-31), and the Chicago Center for Diabetes Translation Research. L. E. E. was supported by NIH/NIDDK (K24DK093699) and NIH/NIDDK (R01DK098529). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. NR 64 TC 5 Z9 5 U1 3 U2 10 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0160-7715 EI 1573-3521 J9 J BEHAV MED JI J. Behav. Med. PD APR PY 2015 VL 38 IS 2 BP 363 EP 371 DI 10.1007/s10865-014-9611-4 PG 9 WC Psychology, Clinical SC Psychology GA CD5NV UT WOS:000351135900017 PM 25420694 ER PT J AU Rachidi, S Sun, SL Wu, BX Jones, E Drake, RR Ogretmen, B Cowart, LA Clarke, CJ Hannun, YA Chiosis, G Liu, B Li, ZH AF Rachidi, Saleh Sun, Shaoli Wu, Bill X. Jones, Elizabeth Drake, Richard R. Ogretmen, Besim Cowart, L. Ashley Clarke, Christopher J. Hannun, Yusuf A. Chiosis, Gabriela Liu, Bei Li, Zihai TI Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis SO JOURNAL OF HEPATOLOGY LA English DT Article DE grp94; Molecular chaperone; Liver cancer; gp96 ID TOLL-LIKE RECEPTORS; GLUCOSE-REGULATED PROTEINS; HEPATIC STEATOSIS; MOLECULAR-MECHANISMS; SIGNAL-TRANSDUCTION; THERAPEUTIC-TARGET; MASTER CHAPERONE; MOUSE MODEL; ER STRESS; CERAMIDE AB Background & Aims: gp96, or grp94, is an endoplasmic reticulum (ER)-localized heat shock protein 90 paralog that acts as a protein chaperone and plays an important role for example in ER homeostasis, ER stress, Wnt and integrin signaling, and calcium homeostasis, which are vital processes in oncogenesis. However, the cancer-intrinsic function of gp96 remains controversial. Methods: We studied the roles of gp96 in liver biology in mice via an Albumin promoter-driven Cre recombinase-mediated disruption of gp96 gene, hsp90b1. The impact of gp96 status on hepatic carcinogenesis in response to diethyl-nitrosoamine (DENA) was probed. The roles of gp96 on human hepatocellular carcinoma cells (HCC) were also examined pharmacologically with a targeted gp96 inhibitor. Results: We demonstrated that gp96 maintains liver development and hepatocyte function in vivo, and its loss genetically promotes adaptive accumulation of long chain ceramides, accompanied by steatotic regeneration of residual gp96+ hepatocytes. The need for compensatory expansion of gp96+ cells in the gp96- background predisposes mice to develop carcinogen-induced hepatic hyperplasia and cancer from gp96+ but not gp96- hepatocytes. We also found that genetic and pharmacological inhibition of gp96 in human HCCs perturbed multiple growth signals, and attenuated proliferation and expansion. Conclusions: gp96 is a pro-oncogenic chaperone and an attractive therapeutic target for HCC. (C) 2015 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. C1 [Rachidi, Saleh; Wu, Bill X.; Liu, Bei; Li, Zihai] Med Univ S Carolina, Dept Microbiol & Immunol, Charleston, SC 29425 USA. [Rachidi, Saleh; Wu, Bill X.; Liu, Bei; Li, Zihai] Med Univ S Carolina, Hollings Canc Ctr, Charleston, SC 29425 USA. [Sun, Shaoli] Med Univ S Carolina, Dept Pathol, Charleston, SC 29425 USA. [Jones, Elizabeth; Drake, Richard R.] Med Univ S Carolina, Dept Cell & Mol Pharmacol, Charleston, SC 29425 USA. [Ogretmen, Besim; Cowart, L. Ashley] Med Univ S Carolina, Dept Biochem & Mol Biol, Charleston, SC 29425 USA. [Cowart, L. Ashley] Ralph H Johnson Vet Affairs Med Ctr, Charleston, SC USA. [Clarke, Christopher J.; Hannun, Yusuf A.] SUNY Stony Brook, Dept Med, Stony Brook, NY 11794 USA. [Chiosis, Gabriela] Mem Sloan Kettering Canc Ctr, Program Mol Pharmacol & Chem, New York, NY 10021 USA. RP Li, ZH (reprint author), Hollings Canc Ctr, Dept Microbiol & Immunol, Charleston, SC 29425 USA. EM zihai@musc.edu FU NIH [AI070603, AI077283, CA97132]; VA Merit Award [2I0BX000200-04]; Lipidomics Shared Resource, Hollings Cancer Center, Medical University of South Carolina [P30 CA138313]; Lipidomics Core in the SC Lipidomics and Pathobiology COBRE, Department of Biochemistry and Molecular Biology, MUSC [P20 RR017677] FX This study was supported in part by NIH grants AI070603, AI077283 (to ZL), CA97132 (to YAH), and a VA Merit Award 2I0BX000200-04 (to LAC). It was also supported by the Lipidomics Shared Resource, Hollings Cancer Center, Medical University of South Carolina (P30 CA138313) and the Lipidomics Core in the SC Lipidomics and Pathobiology COBRE, Department of Biochemistry and Molecular Biology, MUSC (P20 RR017677). NR 55 TC 11 Z9 12 U1 2 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-8278 EI 1600-0641 J9 J HEPATOL JI J. Hepatol. PD APR PY 2015 VL 62 IS 4 BP 879 EP 888 DI 10.1016/j.jhep.2014.11.010 PG 10 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA CD7WH UT WOS:000351305300019 PM 25463537 ER PT J AU Katiyar, SK AF Katiyar, Santosh K. TI Hsp90 Inhibitor Can Inhibit UV Carcinogenesis SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Editorial Material ID PROTEIN-KINASE-C; SQUAMOUS-CELL CARCINOMAS; INDUCED CUTANEOUS DAMAGE; PHASE-II TRIAL; CANCER; 17-ALLYLAMINO-17-DEMETHOXYGELDANAMYCIN; EPSILON; TARGET; SKIN AB Extensive exposure to solar UVR is a well-recognized etiologic factor for cutaneous non-melanoma skin cancer. In this issue of the Journal, Singh et al. show that topical treatment of the skin with 17-[allylamino]-17-demethoxygeldanamycin (17AAG), a heat-shock protein 90 (Hsp90) inhibitor, prevents UVR-induced squamous cell carcinomas (SCCs) in mice. The inhibitory effect of 17AAG on SCC was associated with the inhibition of the UVR-induced (i) hyperplastic response, (ii) Hsp90 beta-PKC epsilon interaction, and (iii) pStat3 and pAkt expression in mouse skin. C1 [Katiyar, Santosh K.] Univ Alabama Birmingham, Dept Dermatol, Birmingham, AL 35294 USA. [Katiyar, Santosh K.] Birmingham Vet Affairs Med Ctr, Dept Dermatol, Birmingham, AL USA. RP Katiyar, SK (reprint author), Univ Alabama Birmingham, Dept Dermatol, Birmingham, AL 35294 USA. EM skatiyar@uab.edu FU BLRD VA [I01 BX001410]; NCI NIH HHS [CA140832, CA140197, R21 CA140832, R01 CA140197] NR 12 TC 1 Z9 1 U1 0 U2 2 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0022-202X EI 1523-1747 J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2015 VL 135 IS 4 BP 945 EP 947 DI 10.1038/jid.2014.504 PG 3 WC Dermatology SC Dermatology GA CD6GW UT WOS:000351188600006 PM 25785948 ER PT J AU Wang, CH Chan, ED Perng, CL Chian, CF Chen, CW Perng, WC Su, WL AF Wang, Ching-Hsun Chan, Edward D. Perng, Cherng-Lih Chian, Chih-Feng Chen, Chien-Wen Perng, Wann-Cherng Su, Wen-Lin TI Intravenous immunoglobulin replacement therapy to prevent pulmonary infection in a patient with Good's syndrome SO JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION LA English DT Article DE Cytomegalovirus infections; Immunodeficiency; Pneumonia; Thymoma ID IMMUNODEFICIENCY; DISEASE; COMMITTEE; THYMOMA AB Good's syndrome is an acquired immunodeficiency state associated with thymoma and characterized by recurrent pulmonary infections. We describe a 67-year-old woman who presented with respiratory symptoms caused by concomitant disseminated cytomegalovirus infection and Pneumocystis jiroveci pneumonia 38 months after thymectomy for a thymoma. Immunologic analysis revealed hypogammaglobulinemia with absent B-cell population as demonstrated by flow cytometry, consistent with Good's syndrome. Following treatment with sulfamethoxazole/trimethoprim and ganciclovir, the patient improved with resolution of her respiratory symptoms. However, the patient subsequently experienced additional infections, necessitating additional subsequent hospital admissions. During the last admission, intravenous immunoglobulin (IVIG) replacement therapy was initiated and continued after discharge. Infection has been prevented for one year after beginning IVIG replacement therapy. This case reveals that in patients with combined humoral and cell-mediated immune deficiency, concomitant infection with different pathogens is not unusual, and immediate specific therapy is important. Periodic IVIG infusion, to maintain adequate Ig levels, is recommended. Copyright (C) 2012, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. All rights reserved. C1 [Wang, Ching-Hsun] Tri Serv Gen Hosp, Dept Internal Med, Taipei 114, Taiwan. [Chan, Edward D.] Univ Colorado, Anschutz Med Ctr, Div Pulm Sci & Crit Care Med, Denver, CO 80045 USA. [Chan, Edward D.] Denver Vet Affairs Med Ctr, Denver, CO 80220 USA. [Chan, Edward D.] Natl Jewish Hlth, Dept Med, Div Mycobacterial & Resp Infect, Denver, CO 80206 USA. [Perng, Cherng-Lih] Tri Serv Gen Hosp, Dept Pathol, Div Clin Pathol, Taipei 114, Taiwan. [Perng, Cherng-Lih] Natl Def Med Ctr, Grad Inst Pathol, Taipei, Taiwan. [Chian, Chih-Feng; Chen, Chien-Wen; Perng, Wann-Cherng; Su, Wen-Lin] Tri Serv Gen Hosp, Div Pulm & Crit Care Med, Dept Internal Med, Taipei 114, Taiwan. [Perng, Wann-Cherng; Su, Wen-Lin] Natl Def Med Ctr, Taipei, Taiwan. RP Su, WL (reprint author), Tri Serv Gen Hosp, Div Pulm & Crit Care Med, 325,Sect 2,Cheng Kung Rd, Taipei 114, Taiwan. EM soa@mail.ndmctsgh.edu.tw NR 10 TC 4 Z9 4 U1 1 U2 4 PU ELSEVIER TAIWAN PI TAIPEI PA RM N-412, 4F, CHIA HSIN BUILDING 11, NO 96, ZHONG SHAN N ROAD SEC 2, TAIPEI, 10449, TAIWAN SN 1684-1182 EI 1995-9133 J9 J MICROBIOL IMMUNOL JI J. Microbiol. Immunol. Infect. PD APR PY 2015 VL 48 IS 2 BP 229 EP 232 DI 10.1016/j.jmii.2012.09.003 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CD4PY UT WOS:000351067100016 PM 23200552 ER PT J AU Mills, KA Markun, LC San Luciano, M Rizk, R Allen, IE Racine, CA Starr, PA Alberts, JL Ostrem, JL AF Mills, Kelly A. Markun, Leslie C. San Luciano, Marta Rizk, Rami Allen, I. Elaine Racine, Caroline A. Starr, Philip A. Alberts, Jay L. Ostrem, Jill L. TI Effect of subthalamic nucleus deep brain stimulation on dual-task cognitive and motor performance in isolated dystonia SO JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY LA English DT Article ID QUALITY-OF-LIFE; PARKINSONS-DISEASE; PALLIDAL STIMULATION; CERVICAL DYSTONIA; RANDOMIZED-TRIAL; WORKING-MEMORY; FORCE CONTROL; FOLLOW-UP; GAIT; AGE AB Objective Subthalamic nucleus (STN) deep brain stimulation (DBS) can improve motor complications of Parkinson's disease (PD) but may worsen specific cognitive functions. The effect of STN DBS on cognitive function in dystonia patients is less clear. Previous reports indicate that bilateral STN stimulation in patients with PD amplifies the decrement in cognitive-motor dual-task performance seen when moving from a single-task to dual-task paradigm. We aimed to determine if the effect of bilateral STN DBS on dual-task performance in isolated patients with dystonia, who have less cognitive impairment and no dementia, is similar to that seen in PD. Methods Eight isolated predominantly cervical patients with dystonia treated with bilateral STN DBS, with average dystonia duration of 10.5 years and Montreal Cognitive Assessment score of 26.5, completed working memory (n-back) and motor (forced-maintenance) tests under single-task and dual-task conditions while on and off DBS. Results A multivariate, repeated-measures analysis of variance showed no effect of stimulation status (On vs Off) on working memory (F=0.75, p=0.39) or motor function (F=0.22, p=0.69) when performed under single-task conditions, though as working memory task difficulty increased, stimulation disrupted the accuracy of force-tracking. There was a very small worsening in working memory performance (F=9.14, p=0.019) when moving from single-task to dual-tasks when using the 'dual-task loss' analysis. Conclusions This study suggests the effect of STN DBS on working memory and attention may be much less consequential in patients with dystonia than has been reported in PD. C1 [Mills, Kelly A.; Markun, Leslie C.; San Luciano, Marta; Ostrem, Jill L.] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA. [Mills, Kelly A.; Ostrem, Jill L.] San Francisco VA Med Ctr, Parkinsons Dis Res Educ & Clin Ctr, San Francisco, CA USA. [Rizk, Rami; Alberts, Jay L.] Cleveland Clin, Dept Biomed Engn, Cleveland, OH 44106 USA. [Allen, I. Elaine] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA. [Racine, Caroline A.; Starr, Philip A.] Univ Calif San Francisco, Dept Neurosurg, San Francisco, CA 94143 USA. RP Ostrem, JL (reprint author), Univ Calif San Francisco, Surg Movement Disorders Ctr, 1635 Divisadero St,Suite 520,UCSF Box 1838, San Francisco, CA 94143 USA. EM jill.ostrem@ucsf.edu FU NIH/NCRR UCSF-CTSI [UL1RR024131] FX This project was supported by NIH/NCRR UCSF-CTSI Grant Number UL1RR024131. NR 38 TC 4 Z9 4 U1 0 U2 6 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0022-3050 EI 1468-330X J9 J NEUROL NEUROSUR PS JI J. Neurol. Neurosurg. Psychiatry PD APR PY 2015 VL 86 IS 4 BP 404 EP 409 DI 10.1136/jnnp-2014-307942 PG 6 WC Clinical Neurology; Psychiatry; Surgery SC Neurosciences & Neurology; Psychiatry; Surgery GA CD3SK UT WOS:000351000800011 PM 25012202 ER PT J AU Rizk, DV Riad, S Hage, FG AF Rizk, Dana V. Riad, Samy Hage, Fadi G. TI Screening for Coronary Artery Disease in Kidney Transplant Candidates SO JOURNAL OF NUCLEAR CARDIOLOGY LA English DT Editorial Material ID STAGE RENAL-DISEASE; DIABETIC-PATIENTS; SURVIVAL; ASSOCIATION; RECIPIENTS; MORTALITY; FAILURE; DEATH C1 [Rizk, Dana V.] Univ Alabama Birmingham, Dept Med, Div Nephrol, Birmingham, AL 35294 USA. [Riad, Samy] CHRISTUS Transplant Inst, South Texas Renal Care Grp, San Antonio, TX USA. [Hage, Fadi G.] Univ Alabama Birmingham, Div Cardiovasc Dis, Dept Med, Birmingham, AL 35294 USA. [Hage, Fadi G.] Birmingham Vet Affairs Med Ctr, Cardiol Sect, Birmingham, AL USA. RP Hage, FG (reprint author), Univ Alabama Birmingham, Dept Med, Div Cardiovasc Dis, Lyons Harrison Res Bldg 314,1900 Univ BLVD, Birmingham, AL 35294 USA. EM fadihage@uab.edu OI Hage, Fadi/0000-0002-1397-4942 NR 23 TC 3 Z9 3 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1071-3581 EI 1532-6551 J9 J NUCL CARDIOL JI J. Nucl. Cardiol. PD APR PY 2015 VL 22 IS 2 BP 297 EP 300 DI 10.1007/s12350-014-0006-2 PG 4 WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical Imaging SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine & Medical Imaging GA CD4YJ UT WOS:000351092200007 PM 25294435 ER PT J AU AlJaroudi, WA Einstein, AJ Chaudhry, FA Lloyd, SG Hage, FG AF AlJaroudi, Wael A. Einstein, Andrew J. Chaudhry, Farooq A. Lloyd, Steven G. Hage, Fadi G. TI Multi-modality imaging: Bird's-eye view from the 2014 American Heart Association Scientific Sessions SO JOURNAL OF NUCLEAR CARDIOLOGY LA English DT Review DE SPECT; CT; echocardiography; MRI ID HEINZ NIXDORF RECALL; FRACTIONAL FLOW RESERVE; CORONARY-ARTERY-DISEASE; COMPUTED-TOMOGRAPHY ANGIOGRAPHY; POSITRON-EMISSION-TOMOGRAPHY; DIAGNOSTIC PERFORMANCE; CARDIOVASCULAR EVENTS; MYOCARDIAL-INFARCTION; TREADMILL EXERCISE; GENERAL-POPULATION AB A large number of studies were presented at the 2014 American Heart Association Scientific Sessions. In this review, we will summarize key studies in nuclear cardiology, computed tomography, echocardiography, and cardiac magnetic resonance imaging. This brief review will be helpful for readers of the Journal who are interested in being updated on the latest research covering these imaging modalities. C1 [AlJaroudi, Wael A.] Amer Univ Beirut, Med Ctr, Beirut, Lebanon. [Einstein, Andrew J.] Columbia Univ, New York Presbyterian Hosp, Med Ctr, New York, NY USA. [Chaudhry, Farooq A.] Icahn Sch Med Mt Sinai, New York, NY 10029 USA. [Lloyd, Steven G.; Hage, Fadi G.] Univ Alabama Birmingham, Birmingham, AL 35294 USA. [Lloyd, Steven G.; Hage, Fadi G.] Birmingham Vet Affairs Med Ctr, Birmingham, AL USA. RP Hage, FG (reprint author), Univ Alabama Birmingham, Lyons Harrison Res Bldg 314,1900 Univ BLVD, Birmingham, AL 35294 USA. EM fadihage@uab.edu OI Hage, Fadi/0000-0002-1397-4942 FU GE Healthcare; Phillips Healthcare; Astellas Pharma USA. FX Dr. Einstein reports grant support from GE Healthcare and Phillips Healthcare. Dr. Hage reports grant support from Astellas Pharma USA. NR 41 TC 1 Z9 1 U1 3 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1071-3581 EI 1532-6551 J9 J NUCL CARDIOL JI J. Nucl. Cardiol. PD APR PY 2015 VL 22 IS 2 BP 364 EP 371 DI 10.1007/s12350-015-0076-9 PG 8 WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical Imaging SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine & Medical Imaging GA CD4YJ UT WOS:000351092200015 PM 25698480 ER PT J AU Farag, AA Hage, FG AF Farag, Ayman A. Hage, Fadi G. TI Incidentally found giant thymomas by SPECT myocardial perfusion imaging SO JOURNAL OF NUCLEAR CARDIOLOGY LA English DT Editorial Material C1 [Farag, Ayman A.; Hage, Fadi G.] Univ Alabama Birmingham, Dept Med, Div Cardiovasc Dis, Birmingham, AL 35294 USA. [Hage, Fadi G.] Birmingham Vet Affairs Med Ctr, Cardiol Sect, Birmingham, AL USA. RP Farag, AA (reprint author), Univ Alabama Birmingham, Dept Med, Div Cardiovasc Dis, THT 311,1900 Univ BLVD, Birmingham, AL 35294 USA. EM afarag@uab.edu OI Hage, Fadi/0000-0002-1397-4942 NR 7 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1071-3581 EI 1532-6551 J9 J NUCL CARDIOL JI J. Nucl. Cardiol. PD APR PY 2015 VL 22 IS 2 BP 385 EP 387 DI 10.1007/s12350-014-0028-9 PG 3 WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical Imaging SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine & Medical Imaging GA CD4YJ UT WOS:000351092200017 PM 25367454 ER PT J AU Sherman, O Baruch, L AF Sherman, Olga Baruch, Lawrence TI Activated partial thromboplastin time guided dabigatran dose reduction and switch to alternative novel anticoagulant SO JOURNAL OF THROMBOSIS AND THROMBOLYSIS LA English DT Meeting Abstract C1 [Sherman, Olga; Baruch, Lawrence] James J Peters VA Med Ctr, Bronx, NY USA. [Baruch, Lawrence] Mt Sinai Med Ctr, New York, NY 10029 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0929-5305 EI 1573-742X J9 J THROMB THROMBOLYS JI J. Thromb. Thrombolysis PD APR PY 2015 VL 39 IS 3 SI SI MA F15 BP 423 EP 423 PG 1 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA CD6OX UT WOS:000351209800057 ER PT J AU Hughes, HK Korthuis, PT Saha, S Eggly, S Sharp, V Cohn, J Moore, R Beach, MC AF Hughes, Helen Kinsman Korthuis, Philip Todd Saha, Somnath Eggly, Susan Sharp, Victoria Cohn, Jonathan Moore, Richard Beach, Mary Catherine TI A mixed methods study of patient-provider communication about opioid analgesics SO PATIENT EDUCATION AND COUNSELING LA English DT Article DE Communication; Pain; Mixed methods ID AMBULATORY AIDS PATIENTS; CHRONIC PAIN; CARE; EMPATHY; ENCOUNTERS; MANAGEMENT; ATTITUDES; MEDICINE; QUALITY; RATES AB Objective: To describe patient-provider communication about opioid pain medicine and explore how these discussions affect provider attitudes toward patients. Methods: We audio-recorded 45 HIV providers and 423 patients in routine outpatient encounters at four sites across the country. Providers completed post-visit questionnaires assessing their attitudes toward patients. We identified discussions about opioid pain management and analyzed them qualitatively. We used logistic regression to assess the association between opioid discussion and providers' attitudes toward patients. Results: 48 encounters (11% of the total sample) contained substantive discussion of opioid-related pain management. Most conversations were initiated by patients (n = 28, 58%) and ended by the providers (n = 36, 75%). Twelve encounters (25%) contained dialog suggesting a difference of opinion or conflict. Providers more often agreed than disagreed to give the prescription (50% vs. 23%), sometimes reluctantly; in 27% (n = 13) of encounters, no decision was made. Fewer than half of providers (n = 20, 42%) acknowledged the patient's experience of pain. Providers had a lower odds of positive regard for the patient (adjusted OR =.0.51, 95% Cl: 0.27-0.95) when opioids were discussed. Conclusions: Pain management discussions are common in routine outpatient HIV encounters and providers may regard patients less. favorably if opioids are discussed during visits. The sometimes-adversarial nature of these discussions may negatively affect provider attitudes toward patients. Practice implications: Empathy and pain acknowledgment are tools that clinicians can use to facilitate productive discussions of pain management. (C) 2015 Elsevier Ireland Ltd. All rights reserved. C1 [Hughes, Helen Kinsman; Moore, Richard; Beach, Mary Catherine] Johns Hopkins Univ, Baltimore, MD 21287 USA. [Korthuis, Philip Todd; Saha, Somnath] Oregon Hlth & Sci Univ, Portland, OR USA. [Saha, Somnath] Portland VA Med Ctr, Portland, OR USA. [Eggly, Susan; Cohn, Jonathan] Wayne State Univ, Detroit, MI USA. [Sharp, Victoria] St Lukes Roosevelt, New York, NY USA. RP Beach, MC (reprint author), Johns Hopkins Univ, Baltimore, MD 21287 USA. EM mcbeach@jhmi.edu OI Eggly, Susan/0000-0002-8137-6098 FU Health Resources Service Administration; Agency for Healthcare Research and Quality [AHRQ290-01-0012, K08 HS013903-05]; National Institute of Drug Abuse [K23 DA019808]; Department of Veterans Affairs; Robert Wood Johnson Generalist Physician Faculty Scholars Awards; Predoctoral Clinical Research Training Program at Johns Hopkins [UL1-RR025005] FX Funders: This research was supported by a contract from the Health Resources Service Administration and the Agency for Healthcare Research and Quality (AHRQ290-01-0012). In addition, Dr. Korthuis was supported by the National Institute of Drug Abuse (K23 DA019808), Dr. Beach was supported by the Agency for Healthcare Research and Quality (K08 HS013903-05), Dr. Saha was supported by the Department of Veterans Affairs, and both Drs. Beach and Saha were supported by Robert Wood Johnson Generalist Physician Faculty Scholars Awards. Dr. Hughes's was supported by the Predoctoral Clinical Research Training Program at Johns Hopkins (UL1-RR025005) NR 35 TC 4 Z9 4 U1 1 U2 3 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0738-3991 J9 PATIENT EDUC COUNS JI Patient Educ. Couns. PD APR PY 2015 VL 98 IS 4 BP 453 EP 461 DI 10.1016/j.pec.2014.12.003 PG 9 WC Public, Environmental & Occupational Health; Social Sciences, Interdisciplinary SC Public, Environmental & Occupational Health; Social Sciences - Other Topics GA CE2LP UT WOS:000351647400006 PM 25601279 ER PT J AU Zhang, JH AF Zhang, Jianhua TI Teaching the basics of autophagy and mitophagy to redox biologists-Mechanisms and experimental approaches SO REDOX BIOLOGY LA English DT Review DE mTOR; Beclin; LC3; Mitochondria; Neurodegenerative diseases; Aging ID ISOLATED RAT HEPATOCYTES; MICROAUTOPHAGIC VACUOLE INVAGINATION; MITOCHONDRIAL QUALITY-CONTROL; PARKIN-MEDIATED MITOPHAGY; CENTRAL-NERVOUS-SYSTEM; EXTENDS LIFE-SPAN; SELECTIVE AUTOPHAGY; PROTEIN-DEGRADATION; OXIDATIVE STRESS; LYSOSOME FUSION AB Autophagy is a lysosomal mediated degradation activity providing an essential mechanism for recycling cellular constituents, and clearance of excess or damaged lipids, proteins and organelles. Autophagy involves more than 30 proteins and is regulated by nutrient availability, and various stress sensing signaling pathways. This article provides an overview of the mechanisms and regulation of autophagy, its role in health and diseases, and methods for its measurement. Hopefully this teaching review together with the graphic illustrations will be helpful for instructors teaching graduate students who are interested in grasping the concepts and major research areas and introducing recent developments in the held (C) 2015 The Authors. Published by Elsevier B.V. C1 [Zhang, Jianhua] Univ Alabama Birmingham, Ctr Free Rad Biol, Birmingham, AL 35294 USA. [Zhang, Jianhua] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA. [Zhang, Jianhua] Birmingham VA Med Ctr, Dept Vet Affairs, Birmingham, AL USA. RP Zhang, JH (reprint author), Univ Alabama Birmingham, Dept Pathol, Biomed Res Bldg 2,901 19th St South, Birmingham, AL 35294 USA. EM zhanja@uab.edu OI Zhang, Jianhua/0000-0002-2128-9574 FU NIH [R01-NS064090] FX This work was supported by NIH R01-NS064090 (to J.Z.). NR 207 TC 20 Z9 20 U1 2 U2 10 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 2213-2317 J9 REDOX BIOL JI Redox Biol. PD APR PY 2015 VL 4 BP 242 EP 259 DI 10.1016/j.redox.2015.01.003 PG 18 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA CD1DI UT WOS:000350813800028 PM 25618581 ER PT J AU Velez, MI Nambiar, AM AF Velez, Maria I. Nambiar, Anoop M. TI Combination pirfenidone and inhaled N-acetylcysteine therapy for IPF: Does it take these two to tango? SO RESPIROLOGY LA English DT Editorial Material DE acetylcysteine; combination drug therapy; disease progression; idiopathic pulmonary fibrosis; pirfenidone ID IDIOPATHIC PULMONARY-FIBROSIS; MANAGEMENT; EFFICACY; TRIAL C1 [Velez, Maria I.; Nambiar, Anoop M.] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, Div Pulm Dis & Crit Care Med, San Antonio, TX 78229 USA. [Velez, Maria I.; Nambiar, Anoop M.] South Texas Vet Hlth Care Syst, Audie L Murphy VA Hosp, San Antonio, TX USA. RP Velez, MI (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Med, Div Pulm Dis & Crit Care Med, San Antonio, TX 78229 USA. OI Nambiar, Anoop/0000-0003-2778-0433 NR 10 TC 2 Z9 2 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1323-7799 EI 1440-1843 J9 RESPIROLOGY JI Respirology PD APR PY 2015 VL 20 IS 3 BP 359 EP 360 DI 10.1111/resp.12487 PG 2 WC Respiratory System SC Respiratory System GA CD6CE UT WOS:000351175700002 PM 25678074 ER PT J AU Cetas, JS McFarlane, R Kronfeld, K Smitasin, P Liu, JJ Raskin, JS AF Cetas, Justin S. McFarlane, Robin Kronfeld, Kassi Smitasin, Phoebe Liu, Jesse J. Raskin, Jeffrey S. TI Brainstem Opioidergic System Is Involved in Early Response to Experimental SAH SO TRANSLATIONAL STROKE RESEARCH LA English DT Article DE Subarachnoid hemorrhage; Rostral ventromedial medulla; Brainstem; Cerebral blood flow; Modulation; Stroke ID ROSTRAL VENTROMEDIAL MEDULLA; CEREBRAL-BLOOD-FLOW; LIGHTLY ANESTHETIZED RAT; CAUDAL MIDLINE MEDULLA; SUBARACHNOID HEMORRHAGE; CORTICAL PERFUSION; NEURONS; INJURY; PAIN; STIMULATION AB Subarachnoid hemorrhage (SAH) is a form of stroke with high rates of mortality and permanent disability for patients who survive the initial event. Previous research has focused on delayed cerebral vasospasm of large conduit arteries as the cause of poor long-term outcomes after SAH. New evidence suggests that acute failure to restore cerebral blood flow (CBF) after SAH may be setting the stage for delayed ischemic neurological deficits. Our lab previously demonstrated that the rostral ventromedial medulla (RVM), an autonomic and sensorimotor integration center, is important for maintaining CBF after experimental SAH. In this study, we have demonstrated that ablation of mu-opioid receptor containing cells with dermorphin conjugates in the RVM results in a high mortality rate after experimental SAH and, in survivors, causes a dramatic decrease in CBF. Further, locally blocking the mu-opioid receptor with the antagonist naltrexone attenuated the reduction in CBF secondary to experimental SAH. Saturating mu-opioid receptors with the agonist [d-Ala(2),NMe-Phe(4),Gly-ol(5)]-encephalin (DAMGO) had no effect. Taken together, these results suggest that SAH activates opioidergic signaling in the RVM with a resultant reduction in CBF. Further, cells in the RVM that contain mu-opioid receptors are important for survival after acute SAH. We propose that failure of the RVM mu-opioid receptor cells to initiate the compensatory CBF response sets the stage for acute and delayed ischemic injury following SAH. C1 [Cetas, Justin S.] Oregon Hlth & Sci Univ, Portland VA Med Ctr, Portland, OR 97239 USA. [Cetas, Justin S.; McFarlane, Robin; Kronfeld, Kassi; Smitasin, Phoebe; Liu, Jesse J.; Raskin, Jeffrey S.] Oregon Hlth & Sci Univ, Dept Neurol Surg, Portland, OR 97239 USA. RP Cetas, JS (reprint author), Oregon Hlth & Sci Univ, Portland VA Med Ctr, Portland, OR 97239 USA. EM cetasj@ohsu.edu NR 39 TC 6 Z9 6 U1 0 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1868-4483 EI 1868-601X J9 TRANSL STROKE RES JI Transl. Stroke Res. PD APR PY 2015 VL 6 IS 2 BP 140 EP 147 DI 10.1007/s12975-014-0378-2 PG 8 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA CD8AH UT WOS:000351317000007 PM 25417789 ER PT J AU Brautbar, A Leary, E Rasmussen, K Wilson, DP Steiner, RD Virani, S AF Brautbar, Ariel Leary, Emili Rasmussen, Kristen Wilson, Don P. Steiner, Robert D. Virani, Salim TI Genetics of Familial Hypercholesterolemia SO CURRENT ATHEROSCLEROSIS REPORTS LA English DT Article DE Familial hypercholesterolemia (FH); Low-density lipoprotein receptor (LDLR); Apolipoprotein B (APOB); Familial defective apolipoprotein B-100 (FDB); Proprotein convertase subtilisin/kexin type 9 (PCSK9); Autosomal recessive hypercholesterolemia (ARH); LDL receptor adapter protein 1 (LDLRAP1); Genetic counseling (GC); Cascade testing; Penetrance; Cerebrotendinous xanthomatosis (CTX); Sitosterolemia; Cholesterol ester storage disease (CESD) ID AUTOSOMAL-DOMINANT HYPERCHOLESTEROLEMIA; LYSOSOMAL ACID LIPASE; ESTER STORAGE DISEASE; CORONARY-HEART-DISEASE; LDL-RECEPTOR GENE; DEFECTIVE APOLIPOPROTEIN B-100; APOE P.LEU167DEL MUTATION; CEREBROTENDINOUS-XANTHOMATOSIS; RECESSIVE HYPERCHOLESTEROLEMIA; MOLECULAR-GENETICS AB Familial hypercholesterolemia (FH) is a genetic disorder characterized by elevated low-density lipoprotein (LDL) cholesterol and premature cardiovascular disease, with a prevalence of approximately 1 in 200-500 for heterozygotes in North America and Europe. Monogenic FH is largely attributed to mutations in the LDLR, APOB, and PCSK9 genes. Differential diagnosis is critical to distinguish FH from conditions with phenotypically similar presentations to ensure appropriate therapeutic management and genetic counseling. Accurate diagnosis requires careful phenotyping based on clinical and biochemical presentation, validated by genetic testing. Recent investigations to discover additional genetic loci associated with extreme hypercholesterolemia using known FH families and population studies have met with limited success. Here, we provide a brief overview of the genetic determinants, differential diagnosis, genetic testing, and counseling of FH genetics. C1 [Brautbar, Ariel] Cook Childrens Med Ctr, Div Genet, Ft Worth, TX 76104 USA. [Brautbar, Ariel] Baylor Coll Med, Dept Med, Houston, TX 77030 USA. [Brautbar, Ariel] Marshfield Clin Res Fdn, Ctr Human Genet, Marshfield, WI USA. [Leary, Emili] Univ Wisconsin, Sch Pharm, Madison, WI 53706 USA. [Leary, Emili] Marshfield Clin Fdn Med Res & Educ, Clin Pharm Serv, Marshfield, WI USA. [Rasmussen, Kristen] Marshfield Clin Fdn Med Res & Educ, Ctr Human Genet, Marshfield, WI USA. [Wilson, Don P.] Cook Childrens Med Ctr, Div Pediat Endocrinol & Diabet, Ft Worth, TX USA. [Steiner, Robert D.] Marshfield Clin Res Fdn, Marshfield, WI USA. [Steiner, Robert D.] Univ Wisconsin, Dept Pediat, Madison, WI USA. [Virani, Salim] Baylor Coll Med, Michael E DeBakey Vet Affairs Med Ctr, Houston, TX 77030 USA. [Virani, Salim] Baylor Coll Med, Dept Med, Sect Cardiovasc Res, Houston, TX 77030 USA. RP Brautbar, A (reprint author), Cook Childrens Med Ctr, Div Genet, Ft Worth, TX 76104 USA. EM ariel.brautbar@cookchildrens.org; ejwatts@wisc.edu; Rasmussen.kristen@marshfieldclinic.org; don.wilson@cookchildrens.org; steiner.robert@mcrf.mfldclin.edu; virani@bcm.edu OI Virani, Salim/0000-0001-9541-6954 NR 125 TC 10 Z9 10 U1 2 U2 14 PU CURRENT MEDICINE GROUP PI PHILADELPHIA PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA SN 1523-3804 EI 1534-6242 J9 CURR ATHEROSCLER REP JI Curr. Atheroscleros. Rep. PD APR PY 2015 VL 17 IS 4 AR 20 DI 10.1007/s11883-015-0491-z PG 17 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA CD2EM UT WOS:000350887100001 PM 25712136 ER PT J AU Schmitt, NC Duvvuri, U AF Schmitt, Nicole C. Duvvuri, Umamaheswar TI Transoral robotic surgery for oropharyngeal squamous cell carcinoma SO CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY LA English DT Review DE oropharyngeal squamous cell carcinoma; transoral robotic surgery; unknown primary carcinoma ID QUALITY-OF-LIFE; UNKNOWN PRIMARY; FUNCTIONAL OUTCOMES; HUMAN-PAPILLOMAVIRUS; PRIMARY HEAD; CANCER; NECK; TORS; EXPERIENCE; THERAPY AB Purpose of review This article reviews recent information on outcomes, indications, techniques, and cost of transoral robotic surgery (TORS) for oropharyngeal squamous cell carcinoma (OPSCC). New information on comparisons between TORS, conventional surgery techniques, and chemoradiation is also highlighted. Recent findings Consistent with prior reports, recent studies show excellent oncologic and functional outcomes with TORS for OPSCC. As surgeon experience with this relatively new technique has increased, outcomes continue to improve and complications are rare. TORS may also have a role in management of carcinoma of unknown primary site. Compared with other treatment modalities, TORS for OPSCC may result in similar oncologic outcomes, improved functional outcomes, and decreased cost. Summary TORS for OPSCC results in excellent functional and oncologic outcomes. Randomized clinical trials are needed to compare TORS with adjuvant therapy to definitive chemoradiation and will determine whether adjuvant therapy and associated morbidity can be decreased without compromising survival. C1 [Duvvuri, Umamaheswar] Univ Pittsburgh, Med Ctr, Inst Eye & Ear, Dept Otolaryngol, Pittsburgh, PA 15213 USA. VA Pittsburgh Hlth Syst, Pittsburgh, PA USA. RP Duvvuri, U (reprint author), Univ Pittsburgh, Med Ctr, Inst Eye & Ear, Dept Otolaryngol, 200 Lothrop St,Suite 519, Pittsburgh, PA 15213 USA. EM duvvuriu@upmc.edu FU Department of Veterans Affairs, BLSRD; PNC Foundation FX This work was supported in part by funds from the Department of Veterans Affairs, BLSR&D, and the PNC Foundation (U.D.) The views represented in this manuscript do not reflect the views of the United States Government. NR 31 TC 2 Z9 2 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1068-9508 EI 1531-6998 J9 CURR OPIN OTOLARYNGO JI Curr. Opin. Otolaryngol. Head Neck Surg. PD APR PY 2015 VL 23 IS 2 BP 127 EP 131 DI 10.1097/MOO.0000000000000136 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA CD3VL UT WOS:000351010900008 PM 25692632 ER PT J AU Reynolds, DB Walker, RJ Campbell, JA Egede, LE AF Reynolds, D. Brice Walker, Rebekah J. Campbell, Jennifer A. Egede, Leonard E. TI Differential Effect of Race, Education, Gender, and Language Discrimination on Glycemic Control in Adults with Type 2 Diabetes SO DIABETES TECHNOLOGY & THERAPEUTICS LA English DT Article ID OLDER AFRICAN-AMERICAN; SOCIAL DETERMINANTS; HEALTH; MELLITUS; OUTCOMES; DISPARITIES; RACISM; WOMEN; CARE AB Background: Discrimination has been linked to negative health outcomes, but little research has investigated different types of discrimination to determine if some have a greater impact on outcomes. We examined the differential effect of discrimination based on race, level of education, gender, and language on glycemic control in adults with type 2 diabetes. Patients and Methods: Six hundred two patients with type 2 diabetes from two adult primary care clinics in the southeastern United States completed validated questionnaires. Questions included perceived discrimination because of race/ethnicity, level of education, sex/gender, or language. A multiple linear regression model assessed the differential effect of each type of perceived discrimination on glycemic control while adjusting for relevant covariates, including race, site, gender, marital status, duration of diabetes, number of years in school, number of hours worked per week, income, and health status. Results: The mean age was 61.5 years, and the mean duration of diabetes was 12.3 years. Of the sample, 61.6% were men, and 64.9% were non-Hispanic black. In adjusted models, education discrimination remained significantly associated with glycemic control (beta=0.47; 95% confidence interval, 0.03, 0.92). Race, gender and language discrimination were not significantly associated with poor glycemic control in either unadjusted or adjusted analyses. Conclusions: Discrimination based on education was found to be significantly associated with poor glycemic control. The findings suggest that education discrimination may be an important social determinant to consider when providing care to patients with type 2 diabetes and should be assessed separate from other types of discrimination, such as that based on race. C1 [Reynolds, D. Brice; Walker, Rebekah J.; Campbell, Jennifer A.; Egede, Leonard E.] Med Univ S Carolina, Ctr Hlth Dispar Res, Charleston, SC 29425 USA. [Egede, Leonard E.] Med Univ S Carolina, Div Gen Internal Med & Geriatr, Dept Med, Charleston, SC 29425 USA. [Walker, Rebekah J.; Egede, Leonard E.] Ralph H Johnson VA Med Ctr, Hlth Equ & Rural Outreach Innovat Ctr, Charleston Vet Affairs Hlth Serv Res & Dev Ctr In, Charleston, SC USA. RP Egede, LE (reprint author), Med Univ S Carolina, Ctr Hlth Dispar Res, 135 Rutledge Ave,Room 280,POB 250593, Charleston, SC 29425 USA. EM egedel@musc.edu FU National Institute of Diabetes and Digestive and Kidney Disease [K24DK093699-01] FX This study was supported by grant K24DK093699-01 from the National Institute of Diabetes and Digestive and Kidney Disease (Principal Investigator L.E.E.). NR 26 TC 4 Z9 4 U1 1 U2 12 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1520-9156 EI 1557-8593 J9 DIABETES TECHNOL THE JI Diabetes Technol. Ther. PD APR 1 PY 2015 VL 17 IS 4 BP 243 EP 247 DI 10.1089/dia.2014.0285 PG 5 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA CD4MO UT WOS:000351057300004 PM 25549154 ER PT J AU Graff, JN Gordon, MJ Beer, TM AF Graff, Julie N. Gordon, Max J. Beer, Tomasz M. TI Safety and effectiveness of enzalutamide in men with metastatic, castration-resistant prostate cancer SO EXPERT OPINION ON PHARMACOTHERAPY LA English DT Review DE androgen receptor; castration-resistant prostate cancer; enzalutamide; MDV3100 ID ANDROGEN-RECEPTOR; INCREASED SURVIVAL; CHEMOTHERAPY; MITOXANTRONE; ABIRATERONE; PREDNISONE; DOCETAXEL; ANTIANDROGEN; VARIANTS; TRIAL AB Introduction: Enzalutamide (MDV3100) is a second-generation androgen receptor antagonist that improves survival in metastatic, castration-resistant prostate cancer (mCRPC). Alternatives include chemotherapy, radiation, immunotherapy and abiraterone. Areas covered: The Phase I/II study showed early evidence of efficacy and determined that fatigue is the dose-limiting toxicity. Two randomized, placebo-controlled trials have demonstrated superiority of enzalutamide 160 mg by mouth daily over placebo in terms of overall survival, radiographic progression-free survival as well as a broad range of secondary and exploratory end points in men who had received previous chemotherapy (AFFIRM) and in those who were chemotherapy naive (PREVAIL). Common side effects include fatigue, arthralgias and constipation. A post hoc analysis from AFFIRM found that enzalutamide is safe and effective in men aged >= 75 years. The Phase I/II studies as well as AFFIRM and PREVAIL are described in this review. Expert opinion: Enzalutamide extends overall and progression-free survival and is associated with robust response rates and quality of life benefits in men with mCRPC. Enzalutamide has not been proven to be effective in biochemically relapsed disease or in castration-sensitive prostate cancer. It should not be used in men at high risk for seizure, and patients should be counseled about the increased risk of falls. C1 [Graff, Julie N.] OHSU Knight Canc Inst, Portland Vet Affairs Med Ctr, Portland, OR 97239 USA. [Gordon, Max J.] Oregon Hlth & Sci Univ, Portland, OR 97239 USA. [Beer, Tomasz M.] OHSU Knight Canc Inst, Portland, OR 97239 USA. RP Graff, JN (reprint author), OHSU Knight Canc Inst, Portland Vet Affairs Med Ctr, 3710 SW US Vet Hosp Rd, Portland, OR 97239 USA. EM graffj@ohsu.edu FU Astellas Pharma Global; Medivation; Janssen Research Development; Janssen Japan; Research to Practice FX TM Beer has received research funding from Astellas Pharma Global; Medivation; Janssen Research & Development. Acts as paid consultant for Astellas Pharma Global; Janssen Japan; and received payment from Research to Practice for participation in a Certified Nursing Education program which was supported in part by Astellas Pharma Global and Medivation. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. NR 25 TC 1 Z9 1 U1 0 U2 5 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1465-6566 EI 1744-7666 J9 EXPERT OPIN PHARMACO JI Expert Opin. Pharmacother. PD APR PY 2015 VL 16 IS 5 BP 749 EP 754 DI 10.1517/14656566.2015.1016911 PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA CD3IA UT WOS:000350970500012 PM 25687355 ER PT J AU Roza, KA Lee, EJ Meier, DE Goldstein, NE AF Roza, Katherine A. Lee, Eric J. Meier, Diane E. Goldstein, Nathan E. TI A Survey of Bereaved Family Members To Assess Quality of Care on a Palliative Care Unit SO JOURNAL OF PALLIATIVE MEDICINE LA English DT Article ID LIFE CARE; ILL PATIENTS; END; CONSULTATION; PERCEPTIONS; OUTCOMES; EXPERIENCE; DEATH; COST AB Background: More U.S. hospitals are adopting palliative care programs, prompting inquiry about the relationship of palliative care to patient and family satisfaction. This study compares the impact of palliative care units, palliative care consultation, and usual care on bereaved families' perceptions of care quality. Methods: Using the Bereaved Family Survey we conducted interviews with family members of patients who died at Mount Sinai Medical Center between March 2012 and March 2013. Results: Of 108 completed surveys, 31 were in the palliative care unit group, 28 in the consultation service group, and 49 in the usual care group. Family members of patients who died on the palliative care unit were more likely to report that their loved one's end-of-life medical care had been "excellent" as compared to family members of patients who received palliative care consultation or usual care (adjusted OR, 2.06; 95% CI, 1.17-3.61). Family members of palliative care unit patients also reported greater satisfaction with emotional support before the patient's death (adjusted OR, 1.71; 95% CI, 1.01-2.90). We found no significant differences between the consultation service and usual care. Conclusion: Family members of patients who died while receiving care in a dedicated palliative care unit report higher overall satisfaction and emotional support before death as compared to the consultation service or usual care. C1 [Roza, Katherine A.] Icahn Sch Med Mt Sinai, New York, NY 10029 USA. [Lee, Eric J.; Meier, Diane E.; Goldstein, Nathan E.] Icahn Sch Med Mt Sinai, Brookdale Dept Geriatr & Palliat Med, Lilian & Benjamin Hertzberg Palliat Care Inst, New York, NY 10029 USA. [Goldstein, Nathan E.] James J Peters Vet Affairs Med Ctr, Geriatr Res Educ & Clin Ctr, Bronx, NY USA. RP Goldstein, NE (reprint author), Dept Geriatr & Palliat Med, One Gustave L Levy Pl,Box 1070, New York, NY 10029 USA. EM nathan.goldstein@mssm.edu FU Doris Duke Charitable Foundation Clinical Research Fellowship FX Katherine Roza is the recipient of a Doris Duke Charitable Foundation Clinical Research Fellowship. The manuscript's contents are solely the responsibility of the authors and do not necessarily represent the official views of the Doris Duke Charitable Foundation or the Department of Veterans Affairs. The funding body had no role in the collection, analysis, and interpretation of the data or in the writing of the manuscript, or in the decision to submit the manuscript for publication. NR 24 TC 2 Z9 2 U1 1 U2 7 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1096-6218 EI 1557-7740 J9 J PALLIAT MED JI J. Palliat. Med. PD APR 1 PY 2015 VL 18 IS 4 BP 358 EP 365 DI 10.1089/jpm.2014.0172 PG 8 WC Health Care Sciences & Services SC Health Care Sciences & Services GA CD7ML UT WOS:000351274500010 PM 25793359 ER PT J AU Walling, AM Schreibeis-Baum, H Pimstone, N Asch, SM Robinson, L Korlekar, S Lorenz, K Nwajuaku, T Rosenfeld, K AF Walling, Anne M. Schreibeis-Baum, Hannah Pimstone, Neville Asch, Steven M. Robinson, Linda Korlekar, Sheri Lorenz, Karl Nwajuaku, Tracy Rosenfeld, Kenneth TI Proactive Case Finding To Improve Concurrently Curative and Palliative Care in Patients with End-Stage Liver Disease SO JOURNAL OF PALLIATIVE MEDICINE LA English DT Article ID LUNG-CANCER; HEALTH-CARE; OF-LIFE AB Background: Palliative care and preparation for liver transplantation are often perceived as conflicting for patients with end-stage liver disease (ESLD). We sought to improve both simultaneously through a case finding and care coordination quality improvement intervention. Methods: We identified patients with cirrhosis using validated ICD-9 codes and screened them for ESLD by assessing medical records at a VA hospital for either a model for end-stage liver disease (MELD) >= 14 or a diagnosis of hepatocellular carcinoma (HCC) between October 2012 and January 2013. A care coordinator followed veterans from the index hospitalization through April 2013 and encouraged treating physicians to submit liver transplant evaluation consults for all veterans with a MELD >= 14 and palliative care consults for all veterans with a MELD >= 20 or inoperable HCC. Results: We compared rates of consultation for 49 hospitalized veterans and compared their outcomes to 61 pre-intervention veterans. Veterans were more likely to be considered for liver transplantation (77.6% versus 31.1%, p<0.001) and receive palliative care consultation during the intervention period, although the latter finding did not reach statistical significance (62.5% versus 47.1%, p=0.38). Conclusions: Active case finding improved consideration for liver transplantation without decreasing palliative care consultation. C1 [Walling, Anne M.; Schreibeis-Baum, Hannah; Pimstone, Neville; Korlekar, Sheri; Lorenz, Karl; Nwajuaku, Tracy] Univ Calif Los Angeles, David Geffen Sch Med, Greater Los Angeles Vet Affairs Healthcare Syst, Los Angeles, CA 90095 USA. [Walling, Anne M.] Univ Calif Los Angeles, David Geffen Sch Med, Div Gen Internal Med & Hlth Serv Res, Los Angeles, CA 90095 USA. [Asch, Steven M.] VA Palo Alto Healthcare Syst, Palo Alto, CA USA. [Asch, Steven M.] Stanford Univ, Sch Med, Stanford, CA 94305 USA. [Rosenfeld, Kenneth] Sutter Hlth, Res Dev & Disseminat RD&D, Walnut Creek, CA USA. [Robinson, Linda] St Peters Hosp, Helena, MT USA. RP Walling, AM (reprint author), Univ Calif Los Angeles, Dept Gen Internal Med & Hlth Serv Res, 911 Broxton,3D, Los Angeles, CA 90095 USA. EM awalling@mednet.ucla.edu FU quality improvement award through VA HIV, Hepatitis, and Public Health Pathogens, Office of Public Health/Clinical Public Health; NIH/National Center for Advancing Translational Science (NCATS) UCLA CTSI Grant [UL1TR000124]; NIH loan repayment program FX This project was funded by a quality improvement award through VA HIV, Hepatitis, and Public Health Pathogens, Office of Public Health/Clinical Public Health. Dr. Walling also is currently supported by a career development award from NIH/National Center for Advancing Translational Science (NCATS) UCLA CTSI Grant Number UL1TR000124 and the NIH loan repayment program. NR 17 TC 2 Z9 2 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1096-6218 EI 1557-7740 J9 J PALLIAT MED JI J. Palliat. Med. PD APR 1 PY 2015 VL 18 IS 4 BP 378 EP 381 DI 10.1089/jpm.2014.0265 PG 4 WC Health Care Sciences & Services SC Health Care Sciences & Services GA CD7ML UT WOS:000351274500013 PM 25493552 ER PT J AU Shorey, RC Martino, S Lamb, KE LaRowe, SD Ana, EJS AF Shorey, Ryan C. Martino, Steve Lamb, Kayla E. LaRowe, Steven D. Ana, Elizabeth J. Santa TI Change Talk and Relatedness in Group Motivational Interviewing: A Pilot Study SO JOURNAL OF SUBSTANCE ABUSE TREATMENT LA English DT Article DE Change talk; Motivational interviewing; Group motivational interviewing; Substance use; Relatedness ID SUBSTANCE USE DISORDERS; NEGATIVE CONSEQUENCES; ACTIVE INGREDIENTS; DRINKING OUTCOMES; COLLEGE-STUDENTS; CLIENT LANGUAGE; INTERVENTIONS; PSYCHOTHERAPY; MECHANISMS; THERAPY AB Background: Change talk (CT), or client speech in favor of change, is a hypothesized mechanism of action in motivational interviewing (MI) for substance use disorders. Although group-based treatment is the primary treatment modality for the majority of clients seeking substance use treatment, limited research has examined group motivational interviewing (GMI) among this population, and no study has examined CT within GMI. Therefore, in the current study we examined both standard CT (e.g., desire, ability, reason, need) and a novel phenomenon involving CT which we termed 'relatedness,' or the synergistic exchange of CT between and among group members. Method: Data were utilized from an ongoing randomized controlled trial (RCT) examining the effectiveness of GMI relative to a treatment control condition (TCC) among U.S. veteran outpatients with a primary alcohol use disorder at a Veterans Affairs hospital. A subsample of participants (n = 52) from the RCT were randomly assigned to receive GM! or TCC. The majority of participants in the subsample had co-existing psychiatric (88%) and dual diagnosis drug use disorders (38%). Two of four treatment sessions were coded by trained raters for CT and relatedness. Results: Analyses demonstrated that CT and relatedness occurred with greater frequency in GMI compared to TCC, with effect sizes in the large range for each difference. Results held after controlling for number of group members in treatment sessions. Conclusions: Findings suggest that GMI is associated with more frequent CT and relatedness than TCC, consistent with the broader literature demonstrating the influence of MI on CT. (C) 2015 Elsevier Inc. All rights reserved. C1 [Shorey, Ryan C.] Ohio Univ, Athens, OH 45701 USA. [Martino, Steve] Yale Univ, Sch Med, New Haven, CT USA. [Martino, Steve] VA Connecticut Healthcare Syst, West Haven, CT USA. [Lamb, Kayla E.; LaRowe, Steven D.; Ana, Elizabeth J. Santa] Ralph H Johnson VAMC, Charleston, SC USA. [LaRowe, Steven D.; Ana, Elizabeth J. Santa] Med Univ S Carolina, Charleston, SC 29425 USA. RP Shorey, RC (reprint author), Ohio Univ, Dept Psychol, 239 Porter Hall, Athens, OH 45701 USA. EM shorey@ohio.edu OI LaRowe, Steven/0000-0002-7664-2451 FU Clinical Science Research and Development Career Development Award (CDA-2) from the United States (U.S.) Department of Veterans Affairs (Clinical Sciences Research and Development) [CDA-2-016-08S] FX This work was supported by a Clinical Science Research and Development Career Development Award (CDA-2) to Dr. Santa Ana (CDA-2-016-08S) from the United States (U.S.) Department of Veterans Affairs (Clinical Sciences Research and Development). The contents do not represent the views of the U.S. Department of Veterans Affairs or the United States Government. Dr. Santa Ana is Evidence-Based Training Program Coordinator; VISN 7 Homeless Program; Charleston VA Medical Center, Charleston, SC. NR 44 TC 4 Z9 4 U1 1 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0740-5472 J9 J SUBST ABUSE TREAT JI J. Subst. Abus. Treat. PD APR PY 2015 VL 51 BP 75 EP 81 DI 10.1016/j.jsat.2014.11.003 PG 7 WC Psychology, Clinical; Substance Abuse SC Psychology; Substance Abuse GA CD0RM UT WOS:000350781600010 PM 25488505 ER PT J AU Hosseinbor, AP Chung, MK Wu, YC Bendlin, BB Alexander, AL AF Hosseinbor, A. Pasha Chung, Moo K. Wu, Yu-Chien Bendlin, Barbara B. Alexander, Andrew L. TI A 4D hyperspherical interpretation of q-space SO MEDICAL IMAGE ANALYSIS LA English DT Article DE Hyperspherical harmonics; Diffusion propagator; ODF; q-Space indices; Diffusion MRI ID ORIENTATION DISTRIBUTION FUNCTION; DIFFUSION-WEIGHTED MRI; HUMAN BRAIN; SPHERICAL DECONVOLUTION; MODEL-FREE; RECONSTRUCTION; TISSUE; TENSOR; ATTENUATION; COMPUTATION AB 3D q-space can be viewed as the surface of a 40 hypersphere. In this paper, we seek to develop a 4D hyperspherical interpretation of q-space by projecting it onto a hypersphere and subsequently modeling the q-space signal via 40 hyperspherical harmonics (HSH). Using this orthonormal basis, we derive several well-established q-space indices and numerically estimate the diffusion orientation distribution function (dODF). We also derive the integral transform describing the relationship between the diffusion signal and propagator on a hypersphere. Most importantly, we will demonstrate that for hybrid diffusion imaging (HYDI) acquisitions low order linear expansion of the HSH basis is sufficient to characterize diffusion in neural tissue. In fact, the HSH basis achieves comparable signal and better dODF reconstructions than other well-established methods, such as Bessel Fourier orientation reconstruction (BFOR), using fewer fitting parameters. All in all, this work provides a new way of looking at q-space. (C) 2014 Elsevier B.V. All rights reserved. C1 [Hosseinbor, A. Pasha; Chung, Moo K.; Alexander, Andrew L.] Univ Wisconsin, Waisman Lab Brain Imaging & Behav, Madison, WI 53718 USA. [Chung, Moo K.] Univ Wisconsin, Dept Biostat & Med Informat, Madison, WI USA. [Wu, Yu-Chien] Indiana Univ, Ctr Neuroimaging, Indianapolis, IN 46204 USA. [Bendlin, Barbara B.] Univ Wisconsin, William S Middleton Mem Vet Hosp, GRECC, Madison, WI USA. [Alexander, Andrew L.] Univ Wisconsin, Dept Med Phys, Madison, WI 53706 USA. [Alexander, Andrew L.] Univ Wisconsin, Dept Psychiat, Madison, WI 53706 USA. RP Hosseinbor, AP (reprint author), Univ Wisconsin, Waisman Lab Brain Imaging & Behav, Madison, WI 53718 USA. EM hosseinbor@wisc.edu OI Bendlin, Barbara/0000-0002-0580-9875 FU National Institute of Aging [R01 AG037639]; National Institute of Child Health and Human Development [P-30 HD03352]; National Institute of Dental and Craniofacial Research [5T15LM007359]; UW-Madison FX This research was supported by the National Institute of Aging (R01 AG037639), National Institute of Child Health and Human Development (P-30 HD03352), National Institute of Dental and Craniofacial Research (5T15LM007359), and Vilas Associate Award from UW-Madison. NR 50 TC 0 Z9 0 U1 1 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1361-8415 EI 1361-8423 J9 MED IMAGE ANAL JI Med. Image Anal. PD APR PY 2015 VL 21 IS 1 BP 15 EP 28 DI 10.1016/j.media.2014.11.013 PG 14 WC Computer Science, Artificial Intelligence; Computer Science, Interdisciplinary Applications; Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging SC Computer Science; Engineering; Radiology, Nuclear Medicine & Medical Imaging GA CD0PU UT WOS:000350777200002 ER PT J AU Wu, C Sun, DD AF Wu, Connie Sun, Dandan TI GABA receptors in brain development, function, and injury SO METABOLIC BRAIN DISEASE LA English DT Review DE gamma-aminobutyric acid receptors; Chloride transporters; Anoxic-ischemic injury; Periventricular leukomalacia; Schizophrenia; Stroke ID GAMMA-AMINOBUTYRIC-ACID; NEOCORTICAL INHIBITORY SYSTEM; CORTICAL PROGENITOR CELLS; CENTRAL-NERVOUS-SYSTEM; WHITE-MATTER INJURY; GABAERGIC NEURONS; PREFRONTAL CORTEX; VISUAL-CORTEX; PERIVENTRICULAR LEUKOMALACIA; SCHIZOPHRENIC SUBJECTS AB This review presents a brief overview of the gamma-aminobutyric acid (GABA) system in the developing and mature central nervous system (CNS) and its potential connections to pathologies of the CNS. gamma-aminobutyric acid (GABA) is a major neurotransmitter expressed from the embryonic stage and throughout life. At an early developmental stage, GABA acts in an excitatory manner and is implicated in many processes of neurogenesis, including neuronal proliferation, migration, differentiation, and preliminary circuit-building, as well as the development of critical periods. In the mature CNS, GABA acts in an inhibitory manner, a switch mediated by chloride/cation transporter expression and summarized in this review. GABA also plays a role in the development of interstitial neurons of the white matter, as well as in oligodendrocyte development. Although the underlying cellular mechanisms are not yet well understood, we present current findings for the role of GABA in neurological diseases with characteristic white matter abnormalities, including anoxic-ischemic injury, periventricular leukomalacia, and schizophrenia. Development abnormalities of the GABAergic system appear particularly relevant in the etiology of schizophrenia. This review also covers the potential role of GABA in mature brain injury, namely transient ischemia, stroke, and traumatic brain injury/post-traumatic epilepsy. C1 [Wu, Connie] Univ Wisconsin, Dept Neurosci, Madison, WI 53706 USA. [Sun, Dandan] Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15213 USA. [Sun, Dandan] Vet Affairs Pittsburgh Hlth Care Syst, Geriatr Res Educ & Clin Ctr, Pittsburgh, PA 15213 USA. RP Sun, DD (reprint author), Univ Pittsburgh, Sch Med, Dept Neurol, S-598 South Biomed Sci Tower BST,3500 Terrace St, Pittsburgh, PA 15213 USA. EM sund@upmc.edu FU NIH [R01NS38118, R01NS075995] FX This work was supported in part by NIH grant R01NS38118, R01NS075995 (D. Sun). NR 93 TC 10 Z9 11 U1 3 U2 31 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0885-7490 EI 1573-7365 J9 METAB BRAIN DIS JI Metab. Brain Dis. PD APR PY 2015 VL 30 IS 2 BP 367 EP 379 DI 10.1007/s11011-014-9560-1 PG 13 WC Endocrinology & Metabolism; Neurosciences SC Endocrinology & Metabolism; Neurosciences & Neurology GA CD2HA UT WOS:000350894800003 PM 24820774 ER PT J AU Kawabori, M Yenari, MA AF Kawabori, Masahito Yenari, Midori A. TI The role of the microglia in acute CNS injury SO METABOLIC BRAIN DISEASE LA English DT Review DE Microglia; Inflammation; Brain; Spinal cord; Stroke; Trauma ID TRAUMATIC BRAIN-INJURY; SPINAL-CORD-INJURY; FOCAL CEREBRAL-ISCHEMIA; TUMOR-NECROSIS-FACTOR; NITRIC-OXIDE SYNTHASE; ACTIVATED PARENCHYMAL MICROGLIA/MACROPHAGES; INTRACEREBRAL INFLAMMATORY RESPONSE; BLOOD-DERIVED MACROPHAGES; CENTRAL-NERVOUS-SYSTEM; GROWTH-FACTOR-BETA AB Microglia are considered the brain's resident immune cell involved in immune defense, immunocompetence, and phagocytosis. They maintain tissue homeostasis within the brain and spinal cord under normal condition and serves as its initial host defense system. However, when the central nervous system (CNS) faces injury, microglia respond through signaling molecules expressed or released by neighboring cells. Microglial responses are dual in nature. They induce a nonspecific immune response that may exacerbate CNS injury, especially in the acute stages, but are also essential to CNS recovery and repair. The full range of microglial mechanisms have yet to be clarified, but there is accumulating knowledge about microglial activation in acute CNS injury. Microglial responses require hours to days to fully develop, and may present a therapeutic target for intervention with a much longer window of opportunity compare to other neurological treatments. The challenge will be to find ways to selectively suppress the deleterious effects of microglial activation without compromising its beneficial functions. This review aims to provide an overview of the recent progress relating on the deleterious and beneficial effect of microglia in the setting of acute CNS injury and the potential therapeutic intervention against microglial activation to CNS injury. C1 [Kawabori, Masahito; Yenari, Midori A.] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94121 USA. [Kawabori, Masahito; Yenari, Midori A.] San Francisco VA Med Ctr, San Francisco, CA 94121 USA. RP Yenari, MA (reprint author), Univ Calif San Francisco, Dept Neurol, 4150 Clement St, San Francisco, CA 94121 USA. EM yenari@alum.mit.edu FU National Institutes of Health [NS40516]; Veteran's Merit Award; Uehara Foundation; Veterans Affairs Medical Center, San Francisco, California FX This work was supported by grants from the National Institutes of Health (NS40516, to MY), the Veteran's Merit Award (MY), the Uehara Foundation (2013 Research Fellowship, to MK). Grants to MY were administered by the Northern California Institute for Research and Education, and supported by resources of the Veterans Affairs Medical Center, San Francisco, California. NR 164 TC 8 Z9 10 U1 5 U2 26 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0885-7490 EI 1573-7365 J9 METAB BRAIN DIS JI Metab. Brain Dis. PD APR PY 2015 VL 30 IS 2 BP 381 EP 392 DI 10.1007/s11011-014-9531-6 PG 12 WC Endocrinology & Metabolism; Neurosciences SC Endocrinology & Metabolism; Neurosciences & Neurology GA CD2HA UT WOS:000350894800004 PM 24682762 ER PT J AU Murphy, TM O'Donovan, A Mullins, N O'Farrelly, C McCann, A Malone, K AF Murphy, Therese M. O'Donovan, Aoife Mullins, Niamh O'Farrelly, Cliona McCann, Amanda Malone, Kevin TI Anxiety is associated with higher levels of global DNA methylation and altered expression of epigenetic and interleukin-6 genes SO PSYCHIATRIC GENETICS LA English DT Article DE anxiety; DNA methylation; DNA methyltransferase; inflammation; interleukin-6 ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; DEPRESSION SCALE; HOSPITAL ANXIETY; UP-REGULATION; CANCER CELLS; METHYLTRANSFERASE; STRESS; BLOOD; PROTEIN; GROWTH AB ObjectivesAnxiety is associated with elevated levels of the inflammatory cytokine interleukin-6 (IL-6) and an increased risk for diseases with an inflammatory aetiology. In cancer, higher levels of IL-6 have been associated with increased expression of the epigenetic enzymes DNMT1 and Enhancer of Zeste Homolog 2 (EZH2). However, the relationship between IL-6 and DNA methyltransferases (DNMTs) and EZH2 expression has not previously been examined in anxious individuals.MethodsGlobal DNA methylation levels were measured using the Methylflash Methylated DNA Quantification Kit and gene expression levels of the DNMT and EZH2 genes in anxious (n=25) and nonanxious individuals (n=22) were compared using quantitative real-time PCR. Specifically, we investigated whether global DNA methylation or aberrant expression of these genes was correlated with IL-6 mRNA and protein serum levels in anxious individuals.ResultsAnxious participants had significantly higher levels of global DNA methylation compared with controls (P=0.001). There were no differences in the mean mRNA expression levels of the DNMT1/3A/3B, EZH2 and IL-6 genes in anxious individuals compared with controls. However, the expression of DNMT1/3A, EZH2 and IL-6 genes increases with increasing Hospital Anxiety and Depression Scale-Anxiety scores in the anxious cohort only. Interestingly, IL-6 gene expression was correlated strongly with DNMT1/3A/3B and EZH2 expression, highlighting a potential relationship between IL-6 and important epigenetic regulatory enzymes.ConclusionThis study provides novel insight into the relationship between anxiety, epigenetics and IL-6. Moreover, our findings support the hypothesis that changes in DNA methylation profiles may contribute to the biology of anxiety. C1 [Murphy, Therese M.] Univ Exeter, Sch Med, Royal Devon & Exeter Hosp, Exeter EX2 5DW, Devon, England. [O'Donovan, Aoife] Dept Psychiat, San Francisco, CA USA. [O'Donovan, Aoife] Univ Calif San Francisco, San Francisco VA Med Ctr, San Francisco, CA USA. [Mullins, Niamh; Malone, Kevin] St Vincents Univ Hosp, Educ & Res Ctr, Dept Psychiat & Mental Hlth Res, Dublin, Ireland. [McCann, Amanda] Univ Coll Dublin, UCD Sch Med & Med Sci, UCD Conway Inst Biomol & Biomed Res, Dublin 2, Ireland. [O'Farrelly, Cliona] Trinity Coll Dublin, Sch Biochem & Immunol, Dublin, Ireland. RP Murphy, TM (reprint author), Univ Exeter, Sch Med, Royal Devon & Exeter Hosp, Exeter EX2 5DW, Devon, England. EM murphyth@tcd.ie RI ; Murphy, Therese/C-7481-2014 OI Mullins, Niamh/0000-0001-8021-839X; Murphy, Therese/0000-0002-7647-2798; Malone, Kevin M/0000-0001-5665-4706 FU Craig-Dobbin Newman Fellowship in Mental Health; Society in Science - The Branco Weiss Fellowship FX Funding for this study was provided by the Craig-Dobbin Newman Fellowship in Mental Health (T.M. and A.O'D), Society in Science - The Branco Weiss Fellowship (A.O'D). NR 37 TC 7 Z9 7 U1 3 U2 27 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0955-8829 EI 1473-5873 J9 PSYCHIAT GENET JI Psychiatr. Genet. PD APR PY 2015 VL 25 IS 2 BP 71 EP 78 DI 10.1097/YPG.0000000000000055 PG 8 WC Genetics & Heredity; Neurosciences SC Genetics & Heredity; Neurosciences & Neurology GA CD0GW UT WOS:000350749700003 PM 25350786 ER PT J AU Redeker, NS Pigeon, WR Boudreau, EA AF Redeker, Nancy S. Pigeon, Wilfred R. Boudreau, Eilis A. TI Incorporating measures of sleep quality into cancer studies SO SUPPORTIVE CARE IN CANCER LA English DT Review DE Sleep quality; Sleep-wake cycle; Sleep measurement methods; Insomnia; Cancer; Sleep apnea ID COGNITIVE-BEHAVIOR THERAPY; CLOCK GENE-EXPRESSION; STAGE BREAST-CANCER; DAYTIME SLEEPINESS; PROSTATE-CANCER; RADIATION-THERAPY; INFLAMMATORY MARKERS; CLINICAL ONCOLOGY; FAMILY CAREGIVERS; FATIGUE INVENTORY AB Sleep disturbance may influence the development of cancer and responses to treatment. It is also closely tied to recovery and quality of life in cancer patients, survivors, and caregivers, and recent studies have begun to show beneficial effects of sleep-promoting interventions. Despite the importance of sleep to cancer and its treatment and the availability of numerous tools for measuring sleep quality and quantity, sleep measurements are underutilized in cancer studies. This review, written for cancer researchers interested in incorporating sleep measures into their studies, is designed to raise awareness about the importance of sleep and suggests strategies for including sleep evaluation in cancer studies. Inclusion of readily available sleep measures may ultimately improve cancer care by facilitating studies that lead to a greater understanding of how sleep and sleep disturbance influence all aspects of cancer care and the patient experience. C1 [Redeker, Nancy S.] Yale Univ, Sch Nursing, West Haven, CT 06516 USA. [Pigeon, Wilfred R.] Canandaigua VA Med Ctr, Canandaigua, NY 14424 USA. [Pigeon, Wilfred R.] Univ Rochester, Sleep & Neurophysiol Res Lab, Med Ctr, Rochester, NY 14642 USA. [Boudreau, Eilis A.] Oregon Hlth & Sci Univ, Dept Neurol, Portland, OR 97239 USA. [Boudreau, Eilis A.] Oregon Hlth & Sci Univ, Dept Med Informat & Clin Epidemiol, Portland, OR 97239 USA. [Boudreau, Eilis A.] Portland VA Med Ctr, Epilepsy Ctr Excellence, Portland, OR 97239 USA. RP Redeker, NS (reprint author), Yale Univ, Sch Nursing, West Campus,POB 27399, West Haven, CT 06516 USA. EM nancy.redeker@yale.edu RI Redeker, Nancy/Q-8252-2016 OI Redeker, Nancy/0000-0001-7817-2708 FU Sleep Research Network; [5P20NR014126]; [RR028183]; [TR000172] FX This work was funded by 5P20NR014126 (Redeker), RR028183 and TR000172 (Kupfer), and the Sleep Research Network, a consortium of sleep researchers representing the CTSA program. NR 106 TC 2 Z9 2 U1 5 U2 23 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0941-4355 EI 1433-7339 J9 SUPPORT CARE CANCER JI Support. Care Cancer PD APR PY 2015 VL 23 IS 4 BP 1145 EP 1155 DI 10.1007/s00520-014-2537-0 PG 11 WC Oncology; Health Care Sciences & Services; Rehabilitation SC Oncology; Health Care Sciences & Services; Rehabilitation GA CC6RY UT WOS:000350496500034 PM 25510361 ER PT J AU Ullery, BW Kalapatapu, V AF Ullery, Brant W. Kalapatapu, Venkat TI Bilateral reperfusion injury after carotid endarterectomy with contralateral carotid occlusion SO VASCULAR LA English DT Article DE Reperfusion injury; carotid endarterectomy; contralateral carotid occlusion; hyperperfusion syndrome; high risk ID CEREBRAL HYPERPERFUSION SYNDROME; INTRACEREBRAL HEMORRHAGE; INTRACRANIAL HEMORRHAGE; ARTERY OCCLUSION; RISK; REVASCULARIZATION; PREVENTION; STENOSIS; EXPERIENCE; STROKES AB Cerebral hyperperfusion syndrome represents a clinical spectrum characterized by severe unilateral headache, acute changes in mental status, vomiting, seizures, focal neurologic deficits, and, in its most severe form, intracranial hemorrhage. With the exception of one early case report, reperfusion injury to the brain following carotid endarterectomy has been reported only ipsilateral to the side of surgery. We report the unique case of a patient with symptomatic severe right internal carotid artery stenosis and contralateral carotid occlusion who underwent carotid endarterectomy complicated by cerebral hyperperfusion syndrome and associated bilateral intracranial hemorrhage. C1 [Ullery, Brant W.] Stanford Univ, Div Vasc Surg, Stanford, CA 94305 USA. [Kalapatapu, Venkat] Philadelphia Vet Affairs Med Ctr, Dept Surg, Philadelphia, PA USA. RP Ullery, BW (reprint author), Stanford Univ, Med Ctr, Div Vasc Surg, 300 Pasteur Dr,Suite H3600, Stanford, CA 94305 USA. EM ullery@gmail.com NR 36 TC 0 Z9 0 U1 1 U2 4 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1708-5381 EI 1708-539X J9 VASCULAR JI Vascular PD APR PY 2015 VL 23 IS 2 BP 188 EP 192 DI 10.1177/1708538114538254 PG 5 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA CD3EP UT WOS:000350961000015 PM 24903528 ER PT J AU Bean-Mayberry, B Bastian, L Trentalange, M Murphy, TE Skanderson, M Allore, H Reyes-Harvey, E Maisel, NC Gaetano, V Wright, S Haskell, S Brandt, C AF Bean-Mayberry, Bevanne Bastian, Lori Trentalange, Mark Murphy, Terrence E. Skanderson, Melissa Allore, Heather Reyes-Harvey, Evelyn Maisel, Natalya C. Gaetano, Vera Wright, Steven Haskell, Sally Brandt, Cynthia TI Associations Between Provider Designation and Female-specific Cancer Screening in Women Veterans SO MEDICAL CARE LA English DT Article DE cancer screening; prevention; women; veterans; primary-care providers ID FORCE RECOMMENDATION STATEMENT; HEALTH-CARE-DELIVERY; QUALITY-OF-CARE; PREVENTIVE SERVICES; CERVICAL-CANCER; UNITED-STATES; AMBULATORY-CARE; MENTAL-ILLNESS; BREAST; MAMMOGRAPHY AB Background: In 2010, the Department of Veterans Affairs Healthcare System (VA) implemented policy to provide Comprehensive Primary Care (for acute, chronic, and female-specific care) from designated Women's Health providers (DWHPs) at all VA sites. However, since that time no comparisons of quality measures have been available to assess the level of care for women Veterans assigned to these providers. Objectives: To evaluate the associations between cervical and breast cancer screening rates among age-appropriate women Veterans and designation of primary-care provider (DWHP vs. non-DWHP). Research Design: Cross-sectional analyses using the fiscal year 2012 data on VA women's health providers, administrative files, and patient-specific quality measures. Subjects: The sample included 37,128 women Veterans aged 21 through 69 years. Measures: Variables included patient demographic and clinical factors (ie, age, race, ethnicity, mental health diagnoses, obesity, and site), and provider factors (ie, DWHP status, sex, and panel size). Screening measures were defined by age-appropriate subgroups using VA national guidelines. Results: Female-specific cancer screening rates were higher among patients assigned to DWHPs (cervical cytology 94.4% vs. 91.9%, P < 0.0001; mammography 86.3% vs. 83.3%, P < 0.0001). In multivariable models with adjustment for patient and provider characteristics, patients assigned to DWHPs had higher odds of cervical cancer screening (odds ratio, 1.26; 95% confidence interval, 1.07-1.47; P < 0.0001) and breast cancer screening (odds ratio, 1.24; 95% CI, 1.10-1.39; P < 0.0001). Conclusions: As the proportion of women Veterans increases, assignment to DWHPs may raise rate of female-specific cancer screening within VA. Separate evaluation of sex neutral measures is needed to determine whether other measures accrue benefits for patients with DWHPs. C1 [Bean-Mayberry, Bevanne] Univ Calif Los Angeles, David Geffen Sch Med, VA Greater Los Angeles HSR&D Ctr Study Healthcare, Los Angeles, CA 90095 USA. [Bean-Mayberry, Bevanne] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA. [Bastian, Lori; Haskell, Sally; Brandt, Cynthia] VA Connecticut Healthcare Syst, West Haven, CT USA. [Bastian, Lori] Univ Connecticut, Ctr Hlth, Dept Internal Med, Farmington, CT USA. [Trentalange, Mark; Murphy, Terrence E.; Allore, Heather; Haskell, Sally] Sch Med, Dept Internal Med, New Haven, CT USA. [Skanderson, Melissa] VA Pittsburgh Hlth Care Syst, Pittsburgh, PA USA. [Reyes-Harvey, Evelyn] VHA Off Informat & Analyt 10P2, Durham, NC USA. [Maisel, Natalya C.] VA Palo Alto Hlth Care Syst, HSR&D Ctr Innovat Implementat Ci2i, Palo Alto, CA USA. [Gaetano, Vera] VA Connecticut HSR&D Pain Res Informat Multimorbi, West Haven, CT USA. [Wright, Steven] Off Analyt & Business Intelligence 10P2B, Durham, NC USA. [Haskell, Sally] VA Cent Off, Womens Hlth Serv, Patient Care Serv, Washington, DC USA. [Brandt, Cynthia] Yale Univ, Sch Med, Yale Ctr Med Informat, West Haven, CT 06516 USA. RP Bean-Mayberry, B (reprint author), VA Greater Los Angeles HSR&D Ctr Study Healthcare, 16111 Plummer St 152, Sepulveda, CA 91343 USA. EM bevanne.bean-mayberry@va.gov FU VA Central Office Operations Funds; Yale Claude D. Pepper Older Americans Independence Center [P30AG21342] FX Supported by VA Central Office Operations Funds. This work was partially funded by the Yale Claude D. Pepper Older Americans Independence Center (P30AG21342) to co-authors H.A., T.M., and M.T. NR 47 TC 4 Z9 4 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0025-7079 EI 1537-1948 J9 MED CARE JI Med. Care PD APR PY 2015 VL 53 IS 4 SU 1 BP S47 EP S54 PG 8 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA DS3BL UT WOS:000380657800009 PM 25767975 ER PT J AU Cordasco, KM Huynh, AK Zephyrin, L Hamilton, AB Lau-Herzberg, AE Kessler, CS Yano, EM AF Cordasco, Kristina M. Huynh, Alexis K. Zephyrin, Laurie Hamilton, Alison B. Lau-Herzberg, Amy E. Kessler, Chad S. Yano, Elizabeth M. TI Building Capacity in VA to Provide Emergency Gynecology Services for Women SO MEDICAL CARE LA English DT Article DE Veterans; women's health; emergency care; qualitative methods ID HIDDEN POPULATIONS; VETERANS; IMPLEMENTATION; HEALTH AB Background: Visits to Veterans Administration (VA) emergency departments (EDs) are increasingly being made by women. A 2011 national inventory of VA emergency services for women revealed that many EDs have gaps in their resources and processes for gynecologic emergency care. Objectives: To guide VA in addressing these gaps, we sought to understand factors acting as facilitators and/or barriers to improving VA ED capacity for, and quality of, emergency gynecology care. Research Design: Semistructured interviews with VA emergency and women's health key informants. Subjects: ED directors/providers (n = 14), ED nurse managers (n = 13), and Women Veteran Program Managers (n = 13) in 13 VA facilities. Results: Leadership, staff, space, demand, funding, policies, and community were noted as important factors influencing VA EDs building capacity and improving emergency gynecologic care for women Veterans. These factors are intertwined and cross multiple organizational levels so that each ED's capacity is a reflection not only of its own factors, but also those of its local medical center and non-VA community context as well as VA regional and national trends and policies. Conclusions: Policies and quality improvement initiatives aimed at building VA's emergency gynecologic services for women need to be multifactorial and aimed at multiple organizational levels. Policies need to be flexible to account for wide variations across EDs and their medical center and community contexts. Approaches that build and encourage local leadership engagement, such as evidence-based quality improvement methodology, are likely to be most effective. C1 [Cordasco, Kristina M.; Huynh, Alexis K.; Hamilton, Alison B.; Lau-Herzberg, Amy E.; Yano, Elizabeth M.] VA Greater Los Angeles Healthcare Syst, VA HSR&D Ctr Study Healthcare Innovat Implementat, North Hills, CA USA. [Cordasco, Kristina M.] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. [Cordasco, Kristina M.] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA. [Zephyrin, Laurie] Vet Hlth Adm, VA Womens Hlth Serv, Off Patient Care Serv, Washington, DC USA. [Zephyrin, Laurie] VA New York Harbor Healthcare Syst, New York, NY USA. [Zephyrin, Laurie] NYU, Dept Obstet & Gynecol, Langone Sch Med, New York, NY 10016 USA. [Hamilton, Alison B.] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA. [Kessler, Chad S.] Durham VA Med Ctr, Durham, NC USA. [Kessler, Chad S.] Duke Univ, Sch Med, Dept Emergency Med, Durham, NC USA. [Kessler, Chad S.] Duke Univ, Sch Med, Dept Internal Med, Durham, NC USA. [Yano, Elizabeth M.] Univ Calif Los Angeles, Sch Publ Hlth, Dept Hlth Policy & Management, Los Angeles, CA 90024 USA. RP Cordasco, KM (reprint author), VA Greater Los Angeles Healthcare Syst, 11301 Wilshire Blvd 111 G, Los Angeles, CA 90073 USA. EM kristina.cordasco@va.gov FU VA Women's Health Services; VA Health Services Research & Development Senior Research Career Scientist Award (RCS) [05-195] FX This work was funded by VA Women's Health Services. Dr. Elizabeth Yano's contribution was also funded by a VA Health Services Research & Development Senior Research Career Scientist Award (RCS #05-195). NR 20 TC 3 Z9 3 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0025-7079 EI 1537-1948 J9 MED CARE JI Med. Care PD APR PY 2015 VL 53 IS 4 SU 1 BP S81 EP S87 PG 7 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA DS3BL UT WOS:000380657800014 PM 25767982 ER PT J AU Cordasco, KM Zuchowski, JL Hamilton, AB Kirsh, S Veet, L Saavedra, JO Altman, L Knapp, H Canning, M Washington, DL AF Cordasco, Kristina M. Zuchowski, Jessica L. Hamilton, Alison B. Kirsh, Susan Veet, Laure Saavedra, Joann O. Altman, Lisa Knapp, Herschel Canning, Mark Washington, Donna L. TI Early Lessons Learned in Implementing a Women's Health Educational and Virtual Consultation Program in VA SO MEDICAL CARE LA English DT Article DE veterans; women's health; Continuing Medical Education; qualitative methods ID PRIMARY-CARE; VETERANS; DELIVERY; CLINICS AB Background: Many Veterans Health Administration primary care providers (PCPs) have small female patient caseloads, making it challenging for them to build and maintain their women's health (WH) knowledge and skills. To address this issue, we implemented a longitudinal WH-focused educational and virtual consultation program using televideo conferencing. Objective: To perform a formative evaluation of the program's development and implementation. Research Design: We used mixed methods including participant surveys, semi-structured interviews, stakeholder meeting field notes, and participation logs. We conducted qualitative content analysis for interviews and field notes, and quantitative tabulation for surveys and logs. Subjects: Veterans Health Administration WH PCPs. Results: In 53 postsession surveys received, 47(89%) agreed with the statement, "The information provided in the session would influence my patient care." Among 18 interviewees, all reported finding the program useful for building and maintaining WH knowledge. All interviewees also reported that sessions being conducted during their lunch hour limited consistent participation. Logs showed that PCPs participated more consistently in the 1 health care system that provided time specifically allocated for this program. Key stakeholder discussions revealed that rotating specialists and topics across the breadth of WH limited submission of cases. Conclusions: Our WH education and virtual consultation program is a promising modality for building and maintaining PCP knowledge of WH, and influencing patient care. However, allocated time for PCPs to participate is essential for robust and consistent participation. Narrowing the modality's focus to gynecology, rather than covering the breadth WH topics, may facilitate PCPs having active cased-based questions for sessions. C1 [Cordasco, Kristina M.; Zuchowski, Jessica L.; Hamilton, Alison B.; Canning, Mark; Washington, Donna L.] VA HSR&D Ctr Study Healthcare Innovat Implementat, North Hills, CA USA. [Cordasco, Kristina M.; Zuchowski, Jessica L.; Hamilton, Alison B.; Saavedra, Joann O.; Altman, Lisa; Knapp, Herschel; Canning, Mark; Washington, Donna L.] VA Greater Los Angeles Healthcare Syst, 11301 Wilshire Blvd 111G, Los Angeles, CA 90073 USA. [Cordasco, Kristina M.; Altman, Lisa; Washington, Donna L.] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA. [Hamilton, Alison B.] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA. [Kirsh, Susan] Vet Hlth Adm, Off Patient Care Serv, VHA Specialty Care Serv, Washington, DC USA. [Kirsh, Susan] Louis Stokes Cleveland VA Med Ctr, Cleveland, OH USA. [Kirsh, Susan] Case Western Reserve Univ, Cleveland, OH 44106 USA. [Veet, Laure] Vet Hlth Adm, Off Patient Care Serv, VHA Womens Hlth Serv, Washington, DC USA. [Veet, Laure] Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA. RP Cordasco, KM (reprint author), VA Greater Los Angeles Healthcare Syst, 11301 Wilshire Blvd 111G, Los Angeles, CA 90073 USA. EM kristina.cordasco@va.gov FU Veterans Health Administration (VHA) Health Services Research & Development (HSR&D) CREATE project [CRE-12-031]; VHA HSR&D Center for the Study of Healthcare Implementation, Innovation Policy (CSHIP); VHA Patient Care Services, Office of Specialty Care Transformation (a VHA T-21 Transformational Initiative) FX Supported by Veterans Health Administration (VHA) Health Services Research & Development (HSR&D) CREATE project CRE-12-031; VHA HSR&D Center for the Study of Healthcare Implementation, Innovation & Policy (CSHIP); and VHA Patient Care Services, Office of Specialty Care Transformation (a VHA T-21 Transformational Initiative). NR 16 TC 5 Z9 5 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0025-7079 EI 1537-1948 J9 MED CARE JI Med. Care PD APR PY 2015 VL 53 IS 4 SU 1 BP S88 EP S92 PG 5 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA DS3BL UT WOS:000380657800015 PM 25767983 ER PT J AU deKleijn, M Lagro-Janssen, ALM Canelo, I Yano, EM AF deKleijn, Miriam Lagro-Janssen, Antoine L. M. Canelo, Ismelda Yano, Elizabeth M. TI Creating a Roadmap for Delivering Gender-sensitive Comprehensive Care for Women Veterans Results of a National Expert Panel SO MEDICAL CARE LA English DT Article DE comprehensive care; women's health; sex sensitivity; Veterans ID HEALTH-CARE; SEXUAL TRAUMA; PATCHWORK QUILT; CLINICS; SATISFACTION; ASSOCIATION; AFGHANISTAN; DISPARITIES; INNOVATION; QUALITY AB Background: Women Veterans are a significant minority of users of the VA healthcare system, limiting provider and staff experience meeting their needs in environments historically designed for men. The VA is nonetheless committed to ensuring that women Veterans have access to comprehensive care in environments sensitive to their needs. Objectives: We sought to determine what aspects of care need to be tailored to the needs of women Veterans in order for the VA to deliver gender-sensitive comprehensive care. Research Design: Modified Delphi expert panel process. Subjects: Eleven clinicians and social scientists with expertise in women's health, primary care, and mental health. Measures: Importance of tailoring over 100 discrete aspects of care derived from the Institute of Medicine's definition of comprehensive care and literature-based domains of sex-sensitive care on a 5-point scale. Results: Panelists rated over half of the aspects of care as very-to-extremely important (median score 4+) to tailor to the needs of women Veterans. The panel arrived at 14 priority recommendations that broadly encompassed the importance of (1) the design/delivery of services sensitive to trauma histories, (2) adapting to women's preferences and information needs, and (3) sex awareness and cultural transformation in every facet of VA operations. Conclusions: We used expert panel methods to arrive at consensus on top priority recommendations for improving delivery of sex-sensitive comprehensive care in VA settings. Accomplishment of their breadth will require national, regional, and local strategic action and multilevel stakeholder engagement, and will support VA's national efforts at improving customer service for all Veterans. C1 [deKleijn, Miriam; Lagro-Janssen, Antoine L. M.] Radboud Univ Nijmegen, Med Ctr, Gender & Womens Hlth Unit, Dept Primary & Community Care, Nijmegen, Netherlands. [Canelo, Ismelda; Yano, Elizabeth M.] VA Greater Los Angeles, VA HSR&D Ctr Study Healthcare Innovat Implementat, Sepulveda, CA USA. [Yano, Elizabeth M.] Univ Calif Los Angeles, Dept Hlth Policy & Management, Fielding Sch Publ Hlth, Los Angeles, CA USA. RP Yano, EM (reprint author), VA Greater Los Angeles Healthcare Syst, VA HSR&D Ctr Study Healthcare Innovat Implementat, 16111 Plummer St,Mailcode 152, Sepulveda, CA 91343 USA. EM elizabeth.yano@va.gov RI Lagro, A.L.M./H-8066-2014 FU Women's Health Services, Office of Patient Care Services, Veterans Health Administration, Washington, DC; Radboud University Medical Center, Njimegen, The Netherlands; Dutch Society of Female Doctors; VA Health Services Research & Development Senior Research Career Scientist Award [RCS 05-195] FX Supported by Women's Health Services, Office of Patient Care Services, Veterans Health Administration, Washington, DC. M.d.K.'s effort was covered through a Gender Sensitive Medicine Postdoctoral Fellowship at Radboud University Medical Center, Njimegen, The Netherlands and the Hilly de Roever-Bonnet fund of The Dutch Society of Female Doctors. E.M.Y.'s effort was funded by a VA Health Services Research & Development Senior Research Career Scientist Award (Project # RCS 05-195). NR 48 TC 6 Z9 6 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0025-7079 EI 1537-1948 J9 MED CARE JI Med. Care PD APR PY 2015 VL 53 IS 4 SU 1 BP S156 EP S164 PG 9 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA DS3BL UT WOS:000380657800025 PM 25767971 ER PT J AU Friedman, SA Frayne, SM Berg, E Hamilton, AB Washington, DL Saechao, F Maisel, NC Lin, JY Hoggatt, KJ Phibbs, CS AF Friedman, Sarah A. Frayne, Susan M. Berg, Eric Hamilton, Alison B. Washington, Donna L. Saechao, Fay Maisel, Natalya C. Lin, Julia Y. Hoggatt, Katherine J. Phibbs, Ciaran S. TI Travel Time and Attrition From VHA Care Among Women Veterans How Far is Too Far? SO MEDICAL CARE LA English DT Article; Proceedings Paper CT VA HSR and D Women's Health Research Meeting CY JUL, 2014 CL Arlington, VA DE women veterans; access to health care; rural communities ID VA HEALTH-CARE; MEDICAL-CARE; DISTANCE; ACCESS; LEVEL AB Background: Travel time, an access barrier, may contribute to attrition of women veterans from Veterans Health Administration (VHA) care. Objective: We examined whether travel time influences attrition: (a) among women veterans overall, (b) among new versus established patients, and (c) among rural versus urban patients. Research Design: This retrospective cohort study used logistic regression to estimate the association between drive time and attrition, overall and for new/established and rural/urban patients. Subjects: In total, 266,301 women veteran VHA outpatients in the Fiscal year 2009. Measures: An "attriter" did not return for VHA care during the second through third years after her first 2009 visit (T-0). Drive time (log minutes) was between the patient's residence and her regular source of VHA care. "New" patients had no VHA visits within 3 years before T-0. Models included age, service-connected disability, health status, and utilization as covariates. Results: Overall, longer drive times were associated with higher odds of attrition: drive time adjusted odds ratio = 1.11 (99% confidence interval, 1.09-1.14). The relationship between drive time and attrition was stronger among new patients but was not modified by rurality. Conclusions: Attrition among women veterans is sensitive to longer drive time. Linking new patients to VHA services designed to reduce distance barriers (telemedicine, community-based clinics, mobile clinics) may reduce attrition among women new to VHA. C1 [Friedman, Sarah A.; Frayne, Susan M.; Berg, Eric; Saechao, Fay; Maisel, Natalya C.; Phibbs, Ciaran S.] VA Palo Alto Hlth Care Syst, Ctr Innovat Implementat Ci2i, Palo Alto, CA USA. [Friedman, Sarah A.] Univ Calif Los Angeles, Dept Hlth Policy & Management, Los Angeles, CA USA. [Frayne, Susan M.] VA Palo Alto Hlth Care Syst, Womens Hlth Sect, Med Serv, Palo Alto, CA USA. [Frayne, Susan M.] Stanford Univ, Sch Med, Div Gen Med Disciplines, Stanford, CA 94305 USA. [Frayne, Susan M.; Phibbs, Ciaran S.] Stanford Univ, Sch Med, Ctr Primary Care & Outcomes Res, Stanford, CA 94305 USA. [Hamilton, Alison B.; Washington, Donna L.; Hoggatt, Katherine J.] VA Greater Los Angeles Healthcare Syst, VA HSR&D Ctr Study Healthcare Innovat Implementat, Los Angeles, CA USA. [Hamilton, Alison B.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA. [Washington, Donna L.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA. [Lin, Julia Y.] VA Palo Alto Hlth Care Syst, VA Cooperat Studies Program Coordinating Ctr, Palo Alto, CA USA. [Hoggatt, Katherine J.] Univ Calif Los Angeles, Dept Epidemiol, Los Angeles, CA USA. [Phibbs, Ciaran S.] VA Palo Alto Hlth Care Syst, Hlth Econ Resource Ctr, Palo Alto, CA USA. [Phibbs, Ciaran S.] Stanford Univ, Dept Pediat, Sch Med, Stanford, CA 94305 USA. RP Friedman, SA (reprint author), VA Palo Alto Hlth Care Syst, Ctr Innovat Implementat Ci2i, 795 Willow Rd 152 MPD, Menlo Pk, CA 94025 USA. EM safriedman@mednet.ucla.edu FU Department of Veterans Affairs (VA) Health Services Research & Development Service [CRE 12-019]; VA Women's Health Services; Ms. Friedman's NIH/National Center for Advancing Translational Science (NCATS) UCLA CTSI Grant [TL1TR000121]; Dr Hoggatt's VA HSR&D/QUERI Career Development Award [CDA 11-261] FX Supported in part by the Department of Veterans Affairs (VA) Health Services Research & Development Service (CRE 12-019), by VA Women's Health Services, and by Ms. Friedman's NIH/National Center for Advancing Translational Science (NCATS) UCLA CTSI Grant (TL1TR000121), by Dr Hoggatt's VA HSR&D/QUERI Career Development Award (CDA 11-261). NR 29 TC 5 Z9 5 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0025-7079 EI 1537-1948 J9 MED CARE JI Med. Care PD APR PY 2015 VL 53 IS 4 SU 1 BP S15 EP S22 PG 8 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA DS3BL UT WOS:000380657800005 PM 25767970 ER PT J AU Hamilton, AB Williams, L Washington, DL AF Hamilton, Alison B. Williams, Lindsay Washington, Donna L. TI Military and Mental Health Correlates of Unemployment in a National Sample of Women Veterans SO MEDICAL CARE LA English DT Article DE women Veterans; unemployment; depression; military experiences ID POSTTRAUMATIC-STRESS-DISORDER; INTIMATE PARTNER VIOLENCE; SHORT SCREENING SCALE; OF-THE-LITERATURE; SUPPORTED EMPLOYMENT; PRECARIOUS EMPLOYMENT; DEPRESSIVE SYMPTOMS; PRIMARY-CARE; IMPACT; SERVICES AB Background: The unemployment rate is currently higher among women Veterans than among male Veterans and civilian women. Employment is a key social determinant of health, with unemployment being strongly associated with adverse health. Objective: To identify military-related and health-related characteristics associated with unemployment in women Veterans. Research Design and Subjects: Secondary analysis of workforce participants (n = 1605) in the National Survey of Women Veterans telephone survey. Measures: Demographics, mental health conditions, health care utilization, and military experiences and effects. Unemployment was defined as being in the labor force but unemployed and looking for work. Analysis: The chi(2) analyses to identify characteristics of unemployed women Veterans; logistic regression to identify independent factors associated with unemployment. Results: Ten percent of women Veterans were unemployed. Independent correlates of unemployment were screening positive for depression [odds ratio (OR) = 4.7; 95% confidence interval [CI], 1.8-12.4], military service during wartime (OR = 2.9; 95%, CI 1.1-7.3), and service in the regular military (vs. in the National Guards/Reserves only) (OR = 6.8; 95% CI, 2.2-20.5). Two postactive duty perceptions related to not being respected and understood as a Veteran were each independently associated with unemployment. Conclusions: Whether depression underlies unemployment, is exacerbated by unemployment, or both, it is critical to identify and treat depression among women Veterans, and also to investigate women Veterans' experiences and identities in civilian life. Community-based employers may need education regarding women Veterans' unique histories and strengths. Women who served in the regular military and during wartime may benefit from job assistance before and after they leave the military. Gender-specific adaptation of employment services may be warranted. C1 [Hamilton, Alison B.; Washington, Donna L.] VA Greater Los Angeles Healthcare Syst, VA HSR&D Ctr Study Healthcare Innovat Implementat, 11301 Wilshire Blvd 210A, Los Angeles, CA 90073 USA. [Hamilton, Alison B.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA. [Williams, Lindsay] Univ Calif Los Angeles, Sch Nursing, Los Angeles, CA 90024 USA. [Washington, Donna L.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA. RP Hamilton, AB (reprint author), VA Greater Los Angeles Healthcare Syst, VA HSR&D Ctr Study Healthcare Innovat Implementat, 11301 Wilshire Blvd 210A, Los Angeles, CA 90073 USA. EM alison.hamilton@va.gov FU Department of Veterans Affairs (VA), Women's Health Services within the Office of Patient Care Services; VA Health Services Research and Development (HSRD) Service [SDR-08-270]; VA Health Services Research and Development Service FX The National Survey of Women Veterans was funded by the Department of Veterans Affairs (VA), Women's Health Services within the Office of Patient Care Services, and the VA Health Services Research and Development (HSR&D) Service (SDR-08-270).; A.B.H. and D.L.W. are employed by the Department of Veterans Affairs. A.B.H. and D.L.W. receive research funding from the VA Health Services Research and Development Service. NR 48 TC 2 Z9 2 U1 2 U2 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0025-7079 EI 1537-1948 J9 MED CARE JI Med. Care PD APR PY 2015 VL 53 IS 4 SU 1 BP S32 EP S38 PG 7 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA DS3BL UT WOS:000380657800007 PM 25767973 ER PT J AU Katon, JG Hoggatt, KJ Balasubramanian, V Saechao, FS Frayne, SM Mattocks, KM Feibus, KB Galvan, IV Hickman, R Hayes, PM Haskell, SG Yano, EM Phibbs, CS Zephyrin, LC AF Katon, Jodie G. Hoggatt, Katherine J. Balasubramanian, Vidhya Saechao, Fay S. Frayne, Susan M. Mattocks, Kristin M. Feibus, Karen B. Galvan, Ileana V. Hickman, Renee Hayes, Patricia M. Haskell, Sally G. Yano, Elizabeth M. Phibbs, Ciaran S. Zephyrin, Laurie C. TI Reproductive Health Diagnoses of Women Veterans Using Department of Veterans Affairs Health Care SO MEDICAL CARE LA English DT Article DE women veterans; reproductive health; life course; health care needs ID SEXUAL VIOLENCE; MENTAL-HEALTH; AVAILABILITY; AFGHANISTAN; SERVICES; GENDER; IRAQ AB Background: Little is known regarding the reproductive health needs of women Veterans using Department of Veterans Affairs (VA) health care. Objective: To describe the reproductive health diagnoses of women Veterans using VA health care, how these diagnoses differ across age groups, and variations in sociodemographic and clinical characteristics by presence of reproductive health diagnoses. Research Design: This study is a cross-sectional analysis of VA administrative and clinical data. Subjects: The study included women Veterans using VA health care in FY10. Measures: Reproductive health diagnoses were identified through presence of International Classification of Disease, 9th Revision (ICD-9) codes in VA clinical and administrative records. The prevalence of specific diagnosis categories were examined by age group (18-44, 45-64, >= 65 y) and the most frequent diagnoses for each age group were identified. Sociodemographic and clinical characteristics were compared by presence of at least 1 reproductive health diagnosis. Results: The most frequent reproductive health diagnoses were menstrual disorders and endometriosis among those aged 18-44 years (n = 16,658, 13%), menopausal disorders among those aged 45-64 years (n = 20,707, 15%), and osteoporosis among those aged >= 65 years (n = 8365, 22%). Compared with women without reproductive health diagnoses, those with such diagnoses were more likely to have concomitant mental health (46% vs. 37%, P < 0.001) and medical conditions (75% vs. 63%, P < 0.001). Conclusions: Women Veterans using VA health care have diverse reproductive health diagnoses. The high prevalence of comorbid medical and mental health conditions among women Veterans with reproductive health diagnoses highlights the importance of integrating reproductive health expertise into all areas of VA health care, including primary, mental health, and specialty care. C1 [Katon, Jodie G.] Puget Sound Hlth Care Syst, Dept Vet Affairs VA, HSR&D, Seattle, WA USA. [Katon, Jodie G.; Feibus, Karen B.; Galvan, Ileana V.; Hickman, Renee; Hayes, Patricia M.; Haskell, Sally G.; Zephyrin, Laurie C.] VA Off Patient Care Serv, Womens Hlth Serv, Washington, DC USA. [Katon, Jodie G.] Univ Washington, Sch Publ Hlth, Seattle, WA 98195 USA. [Hoggatt, Katherine J.; Yano, Elizabeth M.] VA Greater Los Angeles Healthcare Syst, VA HSR&D Ctr Study Healthcare Innovat Implementat, Los Angeles, CA USA. [Hoggatt, Katherine J.; Yano, Elizabeth M.] Univ Calif Los Angeles, Jonathan & Karin Fielding Sch Publ Hlth, Los Angeles, CA 90024 USA. [Balasubramanian, Vidhya; Saechao, Fay S.; Frayne, Susan M.; Phibbs, Ciaran S.] VA Palo Alto Hlth Care Syst, VA HSR&D Ctr Innovat Implementat Ci2i, Palo Alto, CA USA. [Frayne, Susan M.; Phibbs, Ciaran S.] Stanford Univ, Sch Med, Stanford, CA 94305 USA. [Mattocks, Kristin M.] VA Cent Western Massachusetts, Leeds, MA USA. [Mattocks, Kristin M.] Univ Massachusetts, Sch Med, Worcester, MA USA. [Haskell, Sally G.] Yale Sch Med, Med, New Haven, CT USA. [Haskell, Sally G.] VA Connecticut Healthcare Syst, West Haven, CT USA. [Phibbs, Ciaran S.] VA Palo Alto Hlth Care Syst, Hlth Econ Resource Ctr, Palo Alto, CA USA. [Zephyrin, Laurie C.] NYU, Langone Med Ctr, New York, NY USA. RP Katon, JG (reprint author), VA Med Ctr, 1660S Columbian Way S-152, Seattle, WA 98108 USA. EM jkaton@u.washington.edu FU Women's Health Services in the Veterans Health Administration of the U.S. Department of Veteran Affairs (VA); VA Office of Academic Affiliations' Associated Health Postdoctoral Fellowship [TPP 61-026]; VA HSR&D Career Scientist Award [RCS 05-195]; VA HSR&D Career Development Award [CDA 11-261] FX Data for this study was originally compiled for the VA State of Reproductive Health Report in Women Veterans. This program evaluation work was supported by Women's Health Services in the Veterans Health Administration of the U.S. Department of Veteran Affairs (VA), and includes program evaluation data from the Women's Health Evaluation Initiative (WHEI) of Women's Health Services. Additional support included a VA Office of Academic Affiliations' Associated Health Postdoctoral Fellowship to J.G.K. (TPP 61-026), a VA HSR&D Career Scientist Award to E.M.Y. (grant RCS 05-195), and a VA HSR&D Career Development Award to K.J.H. (CDA 11-261). NR 28 TC 2 Z9 2 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0025-7079 EI 1537-1948 J9 MED CARE JI Med. Care PD APR PY 2015 VL 53 IS 4 SU 1 BP S63 EP S67 PG 5 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA DS3BL UT WOS:000380657800011 PM 25767978 ER PT J AU Mattocks, K Kroll-Desrosiers, A Zephyrin, L Katon, J Weitlauf, J Bastian, L Haskell, S Brandt, C AF Mattocks, Kristin Kroll-Desrosiers, Aimee Zephyrin, Laurie Katon, Jodie Weitlauf, Julie Bastian, Lori Haskell, Sally Brandt, Cynthia TI Infertility Care Among OEF/OIF/OND Women Veterans in the Department of Veterans Affairs SO MEDICAL CARE LA English DT Article DE women's health; Veterans; infertility ID SELF-REPORTED INFERTILITY; GULF-WAR VETERANS; SEXUAL ASSAULT; MENTAL-HEALTH; AVAILABILITY; PREGNANCY; AFGHANISTAN; POPULATION; OUTCOMES; IRAQ AB Background: An increasing number of young women Veterans seek reproductive health care through the VA, yet little is known regarding the provision of infertility care for this population. The VA provides a range of infertility services for Veterans including artificial insemination, but does not provide in vitro fertilization. This study will be the first to characterize infertility care among OEF/OIF/OND women Veterans using VA care. Methods: We analyzed data from the OEF/OIF/OND roster file from the Defense Manpower Data Center (DMDC)-Contingency Tracking System Deployment file of military discharges from October 1, 2001-December 30, 2010, which includes 68,442 women Veterans between the ages of 18 and 45 who utilized VA health care after separating from military service. We examined the receipt of infertility diagnoses and care using ICD-9 and CPT codes. Results: Less than 2% (n = 1323) of OEF/OIF/OND women Veterans received an infertility diagnosis during the study period. Compared with women VA users without infertility diagnosis, those with infertility diagnosis were younger, obese, black, or Hispanic, have a service-connected disability rating, a positive screen for military sexual trauma, and a mental health diagnosis. Overall, 22% of women with an infertility diagnosis received an infertility assessment or treatment. Thirty-nine percent of women Veterans receiving infertility assessment or treatment received this care from non-VA providers. Conclusions: Overall, a small proportion of OEF/OIF/OND women Veterans received infertility diagnoses from the VA during the study period, and an even smaller proportion received infertility treatment. Nearly 40% of those who received infertility treatments received these treatments from non-VA providers, indicating that the VA may need to examine the training and resources needed to provide this care within the VA. Understanding women's use of VA infertility services is an important component of understanding VA's commitment to comprehensive medical care for women Veterans. C1 [Mattocks, Kristin] VA Cent Western Massachusetts Healthcare Syst, 421 N Main St, Leeds, MA 01053 USA. [Mattocks, Kristin; Kroll-Desrosiers, Aimee] Univ Massachusetts, Sch Med, Dept Quantitat Hlth Sci, Worcester, MA USA. [Kroll-Desrosiers, Aimee] Clin & Populat Hlth Res Program, Worcester, MA USA. [Zephyrin, Laurie] VA Cent Off, Reprod Hlth Women Vet Hlth Strateg Healthcare Grp, Washington, DC USA. [Katon, Jodie] VA Puget Sound Hlth Care Syst, Seattle, WA USA. [Katon, Jodie] VA Off Patient Serv, Off Womens Hlth, Washington, DC USA. [Katon, Jodie] Univ Washington, Sch Publ Hlth, Seattle, WA 98195 USA. [Weitlauf, Julie] VA Palo Alto Hlth Care Syst, Palo Alto, CA USA. [Weitlauf, Julie] Stanford Univ, Sch Med, Stanford, CA 94305 USA. [Bastian, Lori] Univ Connecticut, Dept Med, Mansfield, CT USA. [Bastian, Lori] VA Connecticut Healthcare Syst, West Haven, CT USA. [Haskell, Sally] VHA, Comprehens Womens Hlth, Washington, DC USA. [Haskell, Sally] Yale Univ, Sch Med, New Haven, CT USA. [Brandt, Cynthia] VA Connecticut, New Haven, CT USA. [Brandt, Cynthia] Yale Univ, Sch Med, Dept Emergency Med, New Haven, CT USA. RP Mattocks, K (reprint author), VA Cent Western Massachusetts Healthcare Syst, 421 N Main St, Leeds, MA 01053 USA. EM kristin.mattocks@va.gov FU Veteran Affairs Health Services Research and Development FX Supported by Veteran Affairs Health Services Research and Development. NR 23 TC 3 Z9 3 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0025-7079 EI 1537-1948 J9 MED CARE JI Med. Care PD APR PY 2015 VL 53 IS 4 SU 1 BP S68 EP S75 PG 8 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA DS3BL UT WOS:000380657800012 PM 25767979 ER PT J AU Washington, DL Farmer, MM Mor, SS Canning, M Yano, EM AF Washington, Donna L. Farmer, Melissa M. Mor, Su Sun Canning, Mark Yano, Elizabeth M. TI Assessment of the Healthcare Needs and Barriers to VA Use Experienced by Women Veterans Findings From the National Survey of Women Veterans SO MEDICAL CARE LA English DT Article DE women Veterans; health services need; access to care; VA healthcare; health services utilization ID POSTTRAUMATIC-STRESS-DISORDER; SHORT SCREENING SCALE; QUALITY; RELIABILITY; POPULATION; MORTALITY; VALIDITY; ACCESS; LIFE AB Background: Prior regional studies of women Veterans identified barriers to Veterans Affairs (VA) healthcare use. However, these studies do not reflect the demographic profile of women Veterans nationally, recent advances in VA women's healthcare, and the national context of expanded healthcare alternatives. Objective: To characterize health, VA perceptions, barriers, healthcare delivery preferences, and reasons for VA or non-VA healthcare use in a national women Veteran sample. Methods: Cross-sectional, population-based 2008-2009 National Survey of Women Veterans (n = 3611). Results: VA users had worse physical and mental health than non-VA-only users and healthcare nonusers. Older women Veterans had worse physical health, whereas younger groups had worse mental health. Healthcare use was highest for dual users, followed by VA-only users, but did not differ by age group. Healthcare nonusers were most likely to lack a regular source for healthcare. Perceptions of VA care quality and sex-appropriateness were highest for VA-only, followed by dual, then non-VA-only users. VA perceptions were guided by personal experience for 90% of VA users, versus media or other second-hand sources for 70% of other groups. Non-VA-only users and healthcare nonusers had more knowledge gaps about VA and misperceptions about VA eligibility and services; non-VA-only users more likely encountered VA enrollment barriers. Conclusions: Many nonusers had healthcare needs that were not met. Positive VA perceptions by women with first-hand VA experience, contrasted with VA knowledge gaps by those without such exposure, suggests the need for more education about available VA healthcare services. VA planning should account for mental health needs and healthcare use by younger women Veterans. C1 [Washington, Donna L.; Farmer, Melissa M.; Mor, Su Sun; Canning, Mark; Yano, Elizabeth M.] VA Greater Los Angeles Healthcare Syst, VA Greater Los Angeles Hlth Serv Res & Dev HSR&D, Sepulveda, CA USA. [Washington, Donna L.; Farmer, Melissa M.; Mor, Su Sun; Canning, Mark; Yano, Elizabeth M.] VA Greater Los Angeles Healthcare Syst, VA Greater Los Angeles Hlth Serv Res & Dev HSR&D, Los Angeles, CA USA. [Washington, Donna L.] Univ Calif Los Angeles, Dept Med, Geffen Sch Med, Los Angeles, CA 90024 USA. [Yano, Elizabeth M.] Univ Calif Los Angeles, Dept Hlth Policy & Management, Fielding Sch Publ Hlth, Los Angeles, CA USA. RP Washington, DL (reprint author), VA Greater Los Angeles Healthcare Syst, 11301 Wilshire Blvd,111 G, Los Angeles, CA 90073 USA. EM donna.washington@va.gov FU Department of Veterans Affairs (VA) Women's Health Services, Office of Patient Care Services; VA Health Services Research and Development (HSRD) Service [SDR-08-270]; VA HSR&D Senior Research Career Scientist award [RCS-05-195]; VA Health Services Research and Development Service; VA Office of Patient Care Services FX Supported by the Department of Veterans Affairs (VA) Women's Health Services, Office of Patient Care Services, and the VA Health Services Research and Development (HSR&D) Service (#SDR-08-270). Dr. Yano is supported by a VA HSR&D Senior Research Career Scientist award (#RCS-05-195). Drs Washington, Farmer, and Yano receive research funding from the VA Health Services Research and Development Service. Drs Washington and Yano receive funding from the VA Office of Patient Care Services. NR 34 TC 12 Z9 12 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0025-7079 EI 1537-1948 J9 MED CARE JI Med. Care PD APR PY 2015 VL 53 IS 4 SU 1 BP S23 EP S31 PG 9 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA DS3BL UT WOS:000380657800006 PM 25767972 ER PT J AU Yano, EM AF Yano, Elizabeth M. TI A Partnered Research Initiative to Accelerate Implementation of Comprehensive Care for Women Veterans The VA Women's Health CREATE SO MEDICAL CARE LA English DT Editorial Material ID SERVICES RESEARCH; TRANSLATION C1 [Yano, Elizabeth M.] VA Greater Los Angeles Healthcare Syst, VA HSR&D Ctr Study Healthcare Innovat Implementat, 16111 Plummer St,Mailcode 152, Sepulveda, CA 91343 USA. [Yano, Elizabeth M.] Univ Calif Los Angeles, Dept Hlth Policy & Management, Fielding Sch Publ Hlth, Los Angeles, CA USA. RP Yano, EM (reprint author), VA Greater Los Angeles Healthcare Syst, VA HSR&D Ctr Study Healthcare Innovat Implementat, 16111 Plummer St,Mailcode 152, Sepulveda, CA 91343 USA. EM elizabeth.yano@va.gov FU VA HSR&D Service, Veterans Health Administration through the CREATE initiative [CRE 12-019, CRE 12-038, CRE 12-026, CRE 12-031, CRE-12-008]; VA HSR&D Senior Research Career Scientist Award [RCS 05-195]; VA Women's Health Services in the Office of Patient Care Services, Veterans Health Administration, Washington, DC; VA HSR&D Women's Health Research Network (WHRN) [SDR 10-012] FX Supported by VA HSR&D Service, Veterans Health Administration through the CREATE initiative, comprised of 5 interrelated projects (CRE 12-019: Susan Frayne, MD, MPH; Alison Hamilton, PhD, PIs; CRE 12-038: Elizabeth M. Yano, PhD, MSPH, PI; Danielle Rose, PhD, Co-PI; CRE 12-026: Elizabeth M. Yano, PhD, MSPH, PI; Lisa V. Rubenstein, MD, MSPH, Co-PI; CRE 12-031: Donna L. Washington, MD, MPH, PI; Kristina Cordasco, MD, MPH, Co-PI; and CRE-12-008: Lori Bastian, MD, MPH; Kristin Mattocks, PhD, PIs). E.M.Y. effort was funded by a VA HSR&D Senior Research Career Scientist Award (Project #RCS 05-195). CREATE management was funded by VA Women's Health Services (Chief Consultant, Patricia Hayes, PhD) in the Office of Patient Care Services, Veterans Health Administration, Washington, DC. Also supported by the VA HSR&D Women's Health Research Network (WHRN) (SDR 10-012). NR 25 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0025-7079 EI 1537-1948 J9 MED CARE JI Med. Care PD APR PY 2015 VL 53 IS 4 SU 1 BP S10 EP S14 PG 5 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA DS3BL UT WOS:000380657800004 PM 25767962 ER PT J AU Luan, T Liu, XH Easley, JT Ravishankar, B Puttlitz, C Feeley, BT AF Luan, Tammy Liu, Xuhui Easley, Jeremiah T. Ravishankar, Bharat Puttlitz, Christian Feeley, Brian T. TI Muscle atrophy and fatty infiltration after an acute rotator cuff repair in a sheep model SO MLTJ-MUSCLES LIGAMENTS AND TENDONS JOURNAL LA English DT Article DE acute rotator cuff repair; fatty infiltration; fibrosis; SREBP-1; PPAR gamma ID SUPRASCAPULAR NERVE INJURY; ARTHROSCOPIC REPAIR; SKELETAL-MUSCLE; GENE-EXPRESSION; INTERVAL SLIDES; RAT MODEL; TEARS; DEGENERATION; IMPROVE; RELEASE AB Introduction: rotator cuff tears (RCTs) are the most common tendon injury seen in orthopedic patients. Muscle atrophy and fatty infiltration of the muscle are crucial factors that dictate the outcome following rotator cuff surgery. Though less studied in humans, rotator cuff muscle fibrosis has been seen in animal models as well and may influence outcomes as well. The purpose of this study was to determine if the rotator cuff would develop muscle changes even in the setting of an acute repair in a sheep model. We hypothesized that fatty infiltration and fibrosis would be present even after an acute repair six months after initial surgery. Methods: twelve female adult sheep underwent an acute rotator cuff tear and immediate repair on the right shoulder. The left shoulder served as a control and did not undergo a tear or a repair. Six months following acute rotator cuff repairs, sheep muscles were harvested to study atrophy, fatty infiltration, and fibrosis by histological analysis, western blotting, and reverse transcription polymerase chain reaction (RT-PCR). Results: the repair group demonstrated an increase expression of muscle atrophy, fatty infiltration, and fibrosis related genes. Significantly increased adipocytes, muscle fatty infiltration, and collagen deposition was observed in rotator cuff muscles in the tendon repair group compared to the control group. Conclusions: rotator cuff muscle undergoes degradation changes including fatty infiltration and fibrosis even after the tendons are repair immediately after rupture. Level of Evidence: Basic Science Study. C1 [Luan, Tammy; Liu, Xuhui; Ravishankar, Bharat] San Francisco VA Med Ctr, Dept Vet Affairs, San Francisco, CA USA. [Liu, Xuhui; Ravishankar, Bharat; Feeley, Brian T.] Univ Calif San Francisco, Dept Orthopaed Surg, 1500 Owens Ave,Box 3004, San Francisco, CA 94158 USA. [Easley, Jeremiah T.; Puttlitz, Christian] Colorado State Univ, Ft Collins, CO 80523 USA. RP Feeley, BT (reprint author), Univ Calif San Francisco, Dept Orthopaed Surg, 1500 Owens Ave,Box 3004, San Francisco, CA 94158 USA. EM feeleyb@orthosurg.ucsf.edu NR 46 TC 5 Z9 5 U1 0 U2 2 PU CIC EDIZIONI INT PI ROME PA CORSO TRIESTE 42, ROME, 00198, ITALY SN 2240-4554 J9 MLTJ-MUSCLE LIGAMENT JI MLTJ-Muscles Ligaments Tendons J. PD APR-JUN PY 2015 VL 5 IS 2 BP 106 EP 112 DI 10.11138/mltj/2015.5.2.106 PG 7 WC Orthopedics SC Orthopedics GA DZ2TT UT WOS:000385695200010 PM 26261789 ER PT J AU Liu, XH Joshi, S Ravishankar, B Laron, D Kim, HT Feeley, BT AF Liu, Xuhui Joshi, Sunil Ravishankar, Bharat Laron, Dominique Kim, Hubert T. Feeley, Brian T. TI Bone morphogenetic protein signaling in rotator cuff muscle atrophy and fatty infiltration SO MLTJ-MUSCLES LIGAMENTS AND TENDONS JOURNAL LA English DT Article DE atrophy; BMP; fatty infiltration; muscle; rotator cuff tear ID INDUCED HETEROTOPIC OSSIFICATION; SUPRASCAPULAR NERVE INJURY; MOUSE MODEL; REPAIR; TEARS; MASS; AUTOPHAGY AB Background: reduced mass (atrophy) and increased fat content (fatty infiltration) of rotator cuff muscles are common complications of large or massive rotator cuff (RC) tears, and are believed to be irreversible even after tendon repairs. Clinically, both muscle atrophy and fatty infiltration are important factors contributing to poor functional outcomes after tendon repairs. The molecular mechanism of RC muscle atrophy and FI remains undefined. In this study, we investigated the role of bone morphogenetic proteins (BMP) signaling in RC muscle atrophy and fatty infiltration using a rat model. Methods: unilateral massive RC tears was induced in adult rats. RC muscles were harvested at 2 and 6 weeks after injury for BMP signaling analysis. In a separate experiment, BMP inhibitor (LDN-193189) was injected to rats through daily intraperitoneal injection. RC muscles from rats in the treated and control groups were harvested at 6 weeks after injury for biochemistry and histology analysis. Results: we found significantly increased BMP-14 and BMP-7 expression in rotator cuff muscles after RCT. Inhibiting BMP signaling resulted in increased muscle atrophy and reduced fatty infiltration in rotator cuff muscle after RC tears. Conclusion: this result suggests that BMP signaling inhibits RC muscle atrophy but promotes fatty infiltration. C1 [Liu, Xuhui; Joshi, Sunil; Ravishankar, Bharat; Kim, Hubert T.; Feeley, Brian T.] San Francisco VA Med Ctr, Dept Vet Affairs, San Francisco, CA USA. [Liu, Xuhui; Ravishankar, Bharat; Laron, Dominique; Kim, Hubert T.; Feeley, Brian T.] Univ Calif San Francisco, Dept Orthopaed Surg, 1500 Owens Ave,Box 3004, San Francisco, CA 94158 USA. RP Feeley, BT (reprint author), Univ Calif San Francisco, Dept Orthopaed Surg, 1500 Owens Ave,Box 3004, San Francisco, CA 94158 USA. EM feeleyb@orthosurg.ucsf.edu FU NIAMS NIH HHS [R03 AR060871]; RRD VA [I01 RX000195] NR 21 TC 2 Z9 2 U1 0 U2 0 PU CIC EDIZIONI INT PI ROME PA CORSO TRIESTE 42, ROME, 00198, ITALY SN 2240-4554 J9 MLTJ-MUSCLE LIGAMENT JI MLTJ-Muscles Ligaments Tendons J. PD APR-JUN PY 2015 VL 5 IS 2 BP 113 EP 119 DI 10.11138/mltj/2015.5.2.113 PG 7 WC Orthopedics SC Orthopedics GA DZ2TT UT WOS:000385695200011 PM 26261790 ER PT J AU Arnold, RM Back, AL Barnato, AE Prendergast, TJ Emlet, LL Karpov, I White, PH Nelson, JE AF Arnold, Robert M. Back, Anthony L. Barnato, Amber E. Prendergast, Thomas J. Emlet, Lillian L. Karpov, Irina White, Patrick H. Nelson, Judith E. TI The Critical Care Communication project: Improving fellows' communication skills SO JOURNAL OF CRITICAL CARE LA English DT Article DE Communication; Critical care; Palliative care; Intensive care unit; Standardized patient; End-of-life care ID OF-LIFE CARE; STANDARDIZED FAMILY-MEMBERS; INTENSIVE-CARE; UNIT PATIENTS; PALLIATIVE CARE; HEALTH-CARE; END; CONFERENCES; SATISFACTION; SYMPTOMS AB Purpose: The aimof this study was to develop an evidence-based communication skills training workshop to improve the communication skills of critical care fellows. Materials and methods: Pulmonary and critical care fellows (N = 38) participated in a 3-day communication skills workshop between 2008 and 2010 involving brief didactic talks, faculty demonstration of skills, and facultysupervised small group skills practice sessions with simulated families. Skills included the following: giving bad news, achieving consensus on goals of therapy, and discussing the limitations of life-sustaining treatment. Participants rated their skill levels in a pre-post survey in 11 core communication tasks using a 5-point Likert scale. Results: Of 38 fellows, 36 (95%) completed all 3 days of the workshop. We compared pre and post scores using the Wilcoxon signed rank test. Overall, self-rated skills increased for all 11 tasks. In analyses by participant, 95% reported improvement in at least 1 skill; with improvement in amedian of 10 of 11 skills. Ninety-two percent rated the course as either very good/excellent, and 80% recommended that it be mandatory for future fellows. Conclusions: This 3-day communication skills training program increased critical care fellows' self-reported family meeting communication skills. (C) 2014 Elsevier Inc. All rights reserved. C1 [Arnold, Robert M.; Barnato, Amber E.] Univ Pittsburgh, Dept Med, Div Gen Internal Med, Pittsburgh, PA 15213 USA. [Arnold, Robert M.] Univ Pittsburgh, Med Ctr, UPMC Support & Palliat Care Program, Pittsburgh, PA 15213 USA. [Back, Anthony L.] Univ Washington, Dept Med Oncol, Seattle, WA 98195 USA. [Prendergast, Thomas J.] Oregon Hlth & Sci Univ, Dept Med, Portland, OR USA. [Prendergast, Thomas J.] Portland VA Med Ctr, Sect Pulm & Crit Care, Portland, OR USA. [Emlet, Lillian L.] Univ Pittsburgh, Dept Crit Care Med & Emergency Med, Pittsburgh, PA 15213 USA. [Karpov, Irina] Univ Pittsburgh, Ctr Res Hlth Care, Ctr Data, Pittsburgh, PA 15213 USA. [White, Patrick H.] Univ Pittsburgh, Clin & Translat Sci Program, Pittsburgh, PA 15213 USA. [Nelson, Judith E.] Icahn Sch Med Mt Sinai, Dept Med, Div Pulm Crit Care & Sleep Med, New York, NY 10029 USA. RP Arnold, RM (reprint author), Univ Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213 USA. EM rabob@pitt.edu OI Arnold, Bob/0000-0003-1610-8932 FU National Palliative Care Research Center; Jewish Healthcare Foundation; Arthur Vining Davis Foundation; National Institutes of Health [TL-1, 8TL1R000145] FX This program was supported by grants from the National Palliative Care Research Center, Jewish Healthcare Foundation, and Arthur Vining Davis Foundation. Dr Arnold receives support from the Jewish Healthcare Foundation. Dr White was supported by the National Institutes of Health TL-1 Award # 8TL1R000145. NR 25 TC 15 Z9 15 U1 1 U2 9 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0883-9441 EI 1557-8615 J9 J CRIT CARE JI J. Crit. Care PD APR PY 2015 VL 30 IS 2 BP 250 EP 254 DI 10.1016/j.jcrc.2014.11.016 PG 5 WC Critical Care Medicine SC General & Internal Medicine GA CB8WV UT WOS:000349913800006 PM 25535029 ER PT J AU Tian, HJ Li, CS Zhao, KW Wang, JC Duarte, MEL David, CL Phan, K Atti, E Brochmann, EJ Murray, SS AF Tian, Haijun Li, Chen-Shuang Zhao, Ke-Wei Wang, Jeffrey C. Duarte, M. Eugenia L. David, Cynthia L. Phan, Kevin Atti, Elisa Brochmann, Elsa J. Murray, Samuel S. TI A Carboxy Terminal BMP/TGF-beta Binding Site in Secreted Phosphoprotein 24 kD Independently Affects BMP-2 Activity SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Article DE SECRETED PHOSPHOPROTEIN 24 kD; BONE MORPHOGENETIC PROTEIN 2; BONE RESEARCH ID RODENT MODEL; PROTEIN; PEPTIDE; SPP24; GROWTH AB Secreted phosphoprotein 24kD (spp24) is a bone matrix protein isolated during attempts to identify osteogenic proteins. It is not osteogenic but performs other important roles in the regulation of bone metabolism, at least in part, by binding to and affecting the activity of members of the BMP/TGF- family of cytokines. Spp24 exists in a number of forms that preserve the N-terminus and are truncated at the C-terminus. The hypothesized cytokine binding domain is present within the cystatin domain which is preserved in all of the N-terminal products. In this report, we describe a C-terminal fragment that is distinct from the cystatin domain and which independently binds to BMP-2 and TGF-. This fragment inhibited BMP-2 activity in an ectopic bone forming assay. A shorter C-terminal product did not inhibit BMP-2 activity but improved bone quality induced by BMP-2 and produced increased calcium deposition outside of bone. Spp24 has been used to develop several potential therapeutic proteins. These results provide more information on the function of spp24 and provide other materials that can be exploited for clinical interventions. J. Cell. Biochem. 116: 667-676, 2015. (c) 2014 Wiley Periodicals, Inc. C1 [Tian, Haijun] Second Mil Med Univ, Shanghai Changzheng Hosp, Dept Orthopaed Surg, Shanghai 200003, Peoples R China. [Tian, Haijun; Wang, Jeffrey C.; Phan, Kevin] Univ Calif Los Angeles, Dept Orthopaed Surg, Los Angeles, CA 90024 USA. [Li, Chen-Shuang] Peking Univ Sch & Hosp Stomatol, Dept Orthodont, Beijing 100081, Peoples R China. [Zhao, Ke-Wei; Brochmann, Elsa J.; Murray, Samuel S.] VA Greater Los Angeles Healthcare Syst, Res Serv, North Hills, CA 91343 USA. [Duarte, M. Eugenia L.] Univ Fed Rio de Janeiro, Natl Inst Traumatol & Orthopaed, BR-21941 Rio De Janeiro, Brazil. [David, Cynthia L.] Univ Arizona, Ctr Toxicol, Tucson, AZ 85721 USA. [Atti, Elisa] Univ Calif Los Angeles, Sch Dent, Los Angeles, CA 90024 USA. [Brochmann, Elsa J.; Murray, Samuel S.] VA Greater Los Angeles Healthcare Syst, Geriatr Res Educ & Clin Ctr, North Hills, CA 91343 USA. [Brochmann, Elsa J.; Murray, Samuel S.] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA. RP Tian, HJ (reprint author), Second Mil Med Univ, Shanghai Changzheng Hosp, Dept Orthopaed Surg, 415 Fengyang Rd, Shanghai 200003, Peoples R China. EM haijuntianmd@gmail.com FU Research Service of the Department of Veterans Affairs [1I01BX000511]; NIEHS [ES06694]; NIH/NCI [CA023074] FX Grant sponsor: Research Service of the Department of Veterans Affairs; Grant number: 1I01BX000511; Grant sponsor: NIEHS; Grant number: ES06694; Grant sponsor: NIH/NCI; Grant number: CA023074. NR 17 TC 3 Z9 3 U1 0 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-2312 EI 1097-4644 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD APR PY 2015 VL 116 IS 4 BP 667 EP 676 DI 10.1002/jcb.25023 PG 10 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA CA8IU UT WOS:000349163000020 PM 25418420 ER PT J AU Wang, J Freire, D Knable, L Zhao, W Gong, B Mazzola, P Ho, L Levine, S Pasinetti, GM AF Wang, Jun Freire, Daniel Knable, Lindsay Zhao, Wei Gong, Bing Mazzola, Paolo Ho, Lap Levine, Samara Pasinetti, Giulio M. TI Childhood and Adolescent Obesity and Long-Term Cognitive Consequences During Aging SO JOURNAL OF COMPARATIVE NEUROLOGY LA English DT Article DE obesity; insulin resistance; aging; synaptic plasticity; cognitive function ID IMPAIR SYNAPTIC PLASTICITY; METABOLIC SYNDROME; ALZHEIMERS-DISEASE; MOUSE MODEL; BETA OLIGOMERS; OVERWEIGHT; CHILDREN; RISK; RATS; DIET AB The prevalence of childhood/adolescent obesity and insulin resistance has reached an epidemic level. Obesity's immediate clinical impacts have been extensively studied; however, current clinical evidence underscores the long-term implications. The current study explored the impacts of brief childhood/adolescent obesity and insulin resistance on cognitive function in later life. To mimic childhood/adolescent obesity and insulin resistance, we exposed 9-week-old C57BL/6J mice to a high-fat diet for 15 weeks, after which the mice exhibited diet-induced obesity and insulin resistance. We then put these mice back on a normal low-fat diet, after which the mice exhibited normal body weight and glucose tolerance. However, a spatial memory test in the forms of the Morris water maze (MWM) and contextual fear conditioning at 85 weeks of age showed that these mice had severe deficits in learning and long-term memory consolidation. Mechanistic investigations identified increased expression of histone deacetylases 5, accompanied by reduced expression of brain-derived neurotrophic factor, in the brains 61 weeks after the mice had been off the high-fat diet. Electrophysiology studies showed that hippocampal slices isolated from these mice are more susceptible to synaptic impairments compared with slices isolated from the control mice. We demonstrated that a 15-week occurrence of obesity and insulin resistance during childhood/adolescence induces irreversible epigenetic modifications in the brain that persist following restoration of normal metabolic homeostasis, leading to brain synaptic dysfunction during aging. Our study provides experimental evidence that limited early-life exposure to obesity and insulin resistance may have long-term deleterious consequences in the brain, contributing to the onset/progression of cognitive dysfunction during aging. J. Comp. Neurol. 523:757-768, 2015. (c) 2014 Wiley Periodicals, Inc. C1 [Wang, Jun; Freire, Daniel; Knable, Lindsay; Zhao, Wei; Gong, Bing; Mazzola, Paolo; Ho, Lap; Levine, Samara; Pasinetti, Giulio M.] Mt Sinai Sch Med, Dept Neurol, New York, NY 10029 USA. [Wang, Jun; Pasinetti, Giulio M.] James J Peters Vet Affairs Med Ctr, Geriatr Res Educ & Clin Ctr, Bronx, NY 10468 USA. [Mazzola, Paolo] Univ Milano Bicocca, Dept Hlth Sci, I-20900 Monza, MB, Italy. [Mazzola, Paolo] San Gerardo Univ Hosp, Geriatr Clin, I-20900 Monza, MB, Italy. RP Pasinetti, GM (reprint author), Mt Sinai Sch Med, Dept Neurol, 1 Gustave L Levy Pl,Box 1137, New York, NY 10029 USA. EM giulio.pasinetti@mssm.edu OI Mazzola, Paolo/0000-0002-0484-1136 FU Mount Sinai School of Medicine FX Grant sponsor: Mount Sinai School of Medicine. NR 47 TC 8 Z9 10 U1 2 U2 94 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0021-9967 EI 1096-9861 J9 J COMP NEUROL JI J. Comp. Neurol. PD APR 1 PY 2015 VL 523 IS 5 BP 757 EP 768 DI 10.1002/cne.23708 PG 12 WC Neurosciences; Zoology SC Neurosciences & Neurology; Zoology GA CA0AM UT WOS:000348576500004 PM 25380530 ER PT J AU Lyratzopoulos, G Vedsted, P Singh, H AF Lyratzopoulos, G. Vedsted, P. Singh, H. TI Understanding missed opportunities for more timely diagnosis of cancer in symptomatic patients after presentation SO BRITISH JOURNAL OF CANCER LA English DT Article DE neoplasm; diagnosis; missed opportunities; patient safety; general practice; system factors; errors; quality ID HEALTH-CARE-SYSTEMS; GENERAL-PRACTICE; LUNG-CANCER; ALARM SYMPTOMS; ERRORS; EXPERIENCE; COHORT; RECORD; SAFETY; MODEL AB The diagnosis of cancer is a complex, multi-step process. In this paper, we highlight factors involved in missed opportunities to diagnose cancer more promptly in symptomatic patients and discuss responsible mechanisms and potential strategies to shorten intervals from presentation to diagnosis. Missed opportunities are instances in which post-hoc judgement indicates that alternative decisions or actions could have led to more timely diagnosis. They can occur in any of the three phases of the diagnostic process (initial diagnostic assessment; diagnostic test performance and interpretation; and diagnostic follow-up and coordination) and can involve patient, doctor/care team, and health-care system factors, often in combination. In this perspective article, we consider epidemiological 'signals' suggestive of missed opportunities and draw on evidence from retrospective case reviews of cancer patient cohorts to summarise factors that contribute to missed opportunities. Multi-disciplinary research targeting such factors is important to shorten diagnostic intervals post presentation. Insights from the fields of organisational and cognitive psychology, human factors science and informatics can be extremely valuable in this emerging research agenda. We provide a conceptual foundation for the development of future interventions to minimise the occurrence of missed opportunities in cancer diagnosis, enriching current approaches that chiefly focus on clinical decision support or on widening access to investigations. C1 [Lyratzopoulos, G.] UCL, Dept Epidemiol & Publ Hlth, Hlth Behav Res Ctr, London WC1E 6BT, England. [Lyratzopoulos, G.] Univ Cambridge, Inst Publ Hlth, Dept Publ Hlth & Primary Care, Cambridge Ctr Hlth Serv Res, Cambridge CB2 0SR, England. [Vedsted, P.] Aarhus Univ, Res Ctr Canc Diag Primary Care CaP, Res Unit Gen Practice, Dept Publ Hlth, DK-8000 Aarhus, Denmark. [Singh, H.] Baylor Coll Med, Michael E DeBakey Vet Affairs Med Ctr, Houston Vet Affairs Ctr Innovat Qual Effectivenes, Houston, TX 77030 USA. [Singh, H.] Baylor Coll Med, Sect Hlth Serv Res, Dept Med, Houston, TX 77030 USA. RP Lyratzopoulos, G (reprint author), UCL, Dept Epidemiol & Publ Hlth, Hlth Behav Res Ctr, 1-19 Torrington Pl, London WC1E 6BT, England. EM gl290@medschl.cam.ac.uk RI Vedsted, Peter/C-2583-2008 OI Vedsted, Peter/0000-0003-2113-5599; Lyratzopoulos, Georgios/0000-0002-2873-7421 FU National Institute for Health Research [PDF-2011-04-047]; Cancer Research UK Clinician Scientist Fellowship [A18180]; VA Health Services Research and Development Service [CRE 12-033, USA 14-274]; VA National Center for Patient Safety; Agency for Health Care Research and Quality [R01HS022087]; Houston VA HSR&D Center for Innovations in Quality, Effectiveness and Safety [CIN 13-413]; CaP; Danish Cancer Society; Novo Nordisk Foundation FX We acknowledge the helpful and incisive comments by Dr Rikke Sand Andersen (Aarhus University, Denmark) in conceptualising this piece and in drafts of the manuscript. The work is independent research supported by different funding schemes. GL was supported by a Post-Doctoral Fellowship by the National Institute for Health Research (PDF-2011-04-047) until the end of 2014 and by a Cancer Research UK Clinician Scientist Fellowship award (A18180) from 2015. HS is supported by the VA Health Services Research and Development Service (CRE 12-033; Presidential Early Career Award for Scientists and Engineers USA 14-274), the VA National Center for Patient Safety, the Agency for Health Care Research and Quality (R01HS022087) and in part by the Houston VA HSR&D Center for Innovations in Quality, Effectiveness and Safety (CIN 13-413). PV was supported by CaP, funded by The Danish Cancer Society and the Novo Nordisk Foundation. NR 72 TC 13 Z9 13 U1 4 U2 7 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0007-0920 EI 1532-1827 J9 BRIT J CANCER JI Br. J. Cancer PD MAR 31 PY 2015 VL 112 SU 1 BP S84 EP S91 DI 10.1038/bjc.2015.47 PG 8 WC Oncology SC Oncology GA CJ3GV UT WOS:000355372300013 PM 25734393 ER PT J AU Atkinson, C Qiao, F Yang, XF Zhu, P Reaves, N Kulik, L Goddard, M Holers, VM Tomlinson, S AF Atkinson, Carl Qiao, Fei Yang, Xiaofeng Zhu, Peng Reaves, Nicholas Kulik, Liudmila Goddard, Martin Holers, V. Michael Tomlinson, Stephen TI Targeting Pathogenic Postischemic Self-Recognition by Natural IgM to Protect Against Posttransplantation Cardiac Reperfusion Injury SO CIRCULATION LA English DT Article DE antibodies; complement system proteins; inflammation; ischemia; transplantation ID EPSTEIN-BARR-VIRUS; COMPLEMENT INHIBITION; ISCHEMIA/REPERFUSION INJURY; MYOCARDIAL-ISCHEMIA; ENDOTHELIAL-CELLS; RECEPTOR; ACTIVATION; ANTIBODIES; MICE; DISEASE AB Background-Natural IgM antibodies represent a class of innate pattern recognition receptors that recognize danger-associated molecular patterns expressed on stressed or dying cells. They play important roles in tissue homeostasis by disposing of prenecrotic cells and suppressing inflammation. However, ischemic insult leads to a pathogenic level of IgM binding and complement activation, resulting in inflammation and injury. We investigate the role of self-reactive IgM in the unique setting of transplantation where the donor organ undergoes both cold and warm ischemia and global ischemic insult. Methods and Results-By transplanting hearts from wild-type donor mice into antibody-deficient mice reconstituted with specific self-reactive IgM monoclonal antibodies, we identified neoepitopes expressed after transplantation and demonstrated a key role for IgM recognition of these epitopes in graft injury. With this information, we developed and characterized a therapeutic strategy that exploited the postischemia recognition system of natural antibodies. On the basis of neoepitope identification, we constructed an anti-annexin IV single-chain antibody (scFv) and an scFv linked to Crry, an inhibitor of C3 activation (scFv-Crry). In an allograft transplantation model in which recipients contain a full natural antibody repertoire, both constructs blocked graft IgM binding and complement activation and significantly reduced graft inflammation and injury. Furthermore, scFv-Crry specifically targeted to the transplanted heart and, unlike complement deficiency, did not affect immunity to infection, an important consideration for immunosuppressed transplant recipients. Conclusions-We identified pathophysiologically important epitopes expressed within the heart after transplantation and described a novel translatable strategy for targeted complement inhibition that has several advantages over currently available approaches. C1 [Atkinson, Carl; Qiao, Fei; Yang, Xiaofeng; Zhu, Peng; Reaves, Nicholas; Tomlinson, Stephen] Med Univ S Carolina, Dept Microbiol & Immunol, Charleston, SC 29425 USA. [Kulik, Liudmila; Holers, V. Michael] Univ Colorado Denver, Dept Med & Immunol, Aurora, CO USA. [Goddard, Martin] Papworth Hosp, Dept Pathol, Papworth Everard, Cambs, England. [Tomlinson, Stephen] Ralph H Johnson Vet Affairs Med Ctr, Charleston, SC USA. RP Tomlinson, S (reprint author), Med Univ S Carolina, Dept Microbiol & Immunol, Charleston, SC 29425 USA. EM tomlinss@musc.edu FU National Institutes of Health [RO1 HL 86576, RO1 HL091944]; Veteran's Affairs [1BX001218, 1RX001141]; American Heart Association [SDG AHA 065100]; South Carolina Clinical & Translational Research Institute, Medical University of South Carolina's CTSA, National Institutes of Health/National Center for Advancing Translational Sciences [UL1TR000062] FX This study was supported by grants from the National Institutes of Health (RO1 HL 86576 to Dr Tomlinson, RO1 HL091944 to Dr Atkinson), the Veteran's Affairs (1BX001218 and 1RX001141 to Dr Tomlinson), and the American Heart Association (SDG AHA 065100 to Dr Atkinson). Statistical support was provided through the South Carolina Clinical & Translational Research Institute, Medical University of South Carolina's CTSA, National Institutes of Health/National Center for Advancing Translational Sciences grant UL1TR000062. NR 38 TC 9 Z9 9 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0009-7322 EI 1524-4539 J9 CIRCULATION JI Circulation PD MAR 31 PY 2015 VL 131 IS 13 BP 1171 EP + DI 10.1161/CIRCULATIONAHA.114.010482 PG 17 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA CE6NE UT WOS:000351953300011 PM 25825397 ER PT J AU Hambright, HG Meng, P Kumar, AP Ghosh, R AF Hambright, Heather G. Meng, Peng Kumar, Addanki P. Ghosh, Rita TI Inhibition of PI3K/AKT/mTOR axis disrupts oxidative stress-mediated survival of melanoma cells SO ONCOTARGET LA English DT Article DE Reactive oxygen species; oxidative stress; mTORC1; melanoma; Nexrutine(R) ID AMURENSE BARK EXTRACT; PROSTATE-CANCER; SIGNALING PATHWAY; TRANSGENIC ADENOCARCINOMA; METASTATIC MELANOMA; MALIGNANT-MELANOMA; PANCREATIC-CANCER; REDOX REGULATION; ACTIVATION; NEXRUTINE AB Elevated oxidative stress in cancer cells contributes to hyperactive proliferation and enhanced survival, which can be exploited using agents that increase reactive oxygen species (ROS) beyond a threshold level. Here we show that melanoma cells exhibit an oxidative stress phenotype compared with normal melanocytes, as evidenced by increased total cellular ROS, KEAP1/NRF2 pathway activity, protein damage, and elevated oxidized glutathione. Our overall objective was to test whether augmenting this high oxidative stress level in melanoma cells would inhibit their dependence on oncogenic PI3K/AKT/mTOR-mediated survival. We report that Nexrutine(R) augmented the constitutively elevated oxidative stress markers in melanoma cells, which was abrogated by N-acetyl cysteine (NAC) pre-treatment. Nexrutine(R) disrupted growth homeostasis by inhibiting proliferation, survival, and colony formation in melanoma cells without affecting melanocyte cell viability. Increased oxidative stress in melanoma cells inhibited PI3K/AKT/mTOR pathway through disruption of mTORC1 formation and phosphorylation of downstream targets p70S6K, 4EBP1 and rpS6. NAC pre-treatment reversed inhibition of mTORC1 targets, demonstrating a ROS-dependent mechanism. Overall, our results illustrate the importance of disruption of the intrinsically high oxidative stress in melanoma cells to selectively inhibit their survival mediated by PI3K/AKT/mTOR. C1 [Hambright, Heather G.; Meng, Peng; Kumar, Addanki P.; Ghosh, Rita] Univ Texas Hlth Sci Ctr San Antonio, Dept Urol, San Antonio, TX 78229 USA. [Kumar, Addanki P.; Ghosh, Rita] Univ Texas Hlth Sci Ctr San Antonio, Dept Pharmacol, San Antonio, TX 78229 USA. [Kumar, Addanki P.; Ghosh, Rita] Univ Texas Hlth Sci Ctr San Antonio, Dept Mol Med, San Antonio, TX 78229 USA. [Kumar, Addanki P.; Ghosh, Rita] Univ Texas Hlth Sci Ctr San Antonio, Canc Therapy & Res Ctr, San Antonio, TX 78229 USA. [Kumar, Addanki P.] South Texas Vet Hlth Care Syst, San Antonio, TX 78229 USA. [Meng, Peng] Lawrence Berkley Natl Lab, Div Life Sci, Berkeley, CA 94710 USA. RP Ghosh, R (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Urol, San Antonio, TX 78229 USA. EM ghoshr@uthscsa.edu FU VA Merit [I01BX000-766]; Cancer Therapy and Research Center at the University of Texas Health Science Center at San Antonio [2P30 CA054174-17]; [1R21CA125719] FX This work was funded in part by 1R21CA125719 (RG); VA Merit I01BX000-766 (APK); and through the Cancer Therapy and Research Center at the University of Texas Health Science Center at San Antonio (2P30 CA054174-17). NR 48 TC 16 Z9 17 U1 1 U2 7 PU IMPACT JOURNALS LLC PI ALBANY PA 6211 TIPTON HOUSE, STE 6, ALBANY, NY 12203 USA SN 1949-2553 J9 ONCOTARGET JI Oncotarget PD MAR 30 PY 2015 VL 6 IS 9 BP 7195 EP 7208 PG 14 WC Oncology; Cell Biology SC Oncology; Cell Biology GA CF8GI UT WOS:000352793800052 PM 25749517 ER PT J AU Balevich, EC Haznedar, MM Wang, E Newmark, RE Bloom, R Schneiderman, JS Aronowitz, J Tang, CY Chu, KW Byne, W Buchsbaum, MS Hazlett, EA AF Balevich, Emily C. Haznedar, M. Mehmet Wang, Eugene Newmark, Randall E. Bloom, Rachel Schneiderman, Jason S. Aronowitz, Jonathan Tang, Cheuk Y. Chu, King-Wai Byne, William Buchsbaum, Monte S. Hazlett, Erin A. TI Corpus callosum size and diffusion tensor anisotropy in adolescents and adults with schizophrenia SO PSYCHIATRY RESEARCH-NEUROIMAGING LA English DT Article DE Diffusion tensor imaging; White matter; Schizophrenia spectrum; Magnetic resonance imaging (MRI) ID CORTICAL BRODMANNS AREAS; WHITE-MATTER; MAGNETIC-RESONANCE; ONSET SCHIZOPHRENIA; 1ST-EPISODE SCHIZOPHRENIA; FRACTIONAL ANISOTROPY; IMAGING FINDINGS; MRI; ABNORMALITIES; CONNECTIVITY AB The corpus callosum has been implicated as a region of dysfunctional connectivity in schizophrenia, but the association between age and callosal pathology is unclear. Magnetic resonance imaging (MRO and diffusion-tensor imaging (DTI) were performed on adults (n=34) and adolescents (n=17) with schizophrenia and adult (n=33) and adolescent (n=15) age- and sex-matched healthy controls. The corpus callosum was manually traced on each participant's MRL and the DTI scan was co-registered to the MRL The corpus callosum was divided into five anteroposterior segments. Area and anisotropy were calculated for each segment. Both patient groups demonstrated reduced callosal anisotropy; however, the adolescents exhibited reductions mostly in anterior regions while the reductions were more prominent in posterior regions of the adults. The adolescent patients showed greater decreases in absolute area as compared with the adult patients, particularly in the anterior segments. However, the adults showed greater reductions when area was considered relative to whole brain white matter volume. Our results suggest that the initial stages of the illness are characteiized by deficiencies in frontal connections, and the chronic phase is characterized by deficits in the posterior corpus callosum; or, alternatively, adolescent-onset schizophrenia may represent a different or more severe form of the illness. Published by Elsevier Ireland Ltd. C1 [Balevich, Emily C.; Haznedar, M. Mehmet; Wang, Eugene; Newmark, Randall E.; Bloom, Rachel; Schneiderman, Jason S.; Aronowitz, Jonathan; Byne, William; Hazlett, Erin A.] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA. [Balevich, Emily C.] CUNY, Grad Ctr, New York, NY 10016 USA. [Haznedar, M. Mehmet; Byne, William] James J Peters VA Med Ctr, Outpatient Psychiat Care Ctr, Bronx, NY 10468 USA. [Tang, Cheuk Y.] Icahn Sch Med Mt Sinai, Dept Radiol, New York, NY 10029 USA. [Chu, King-Wai; Byne, William; Hazlett, Erin A.] James J Peters VA Med Ctr, Res & Dev, Bronx, NY 10468 USA. [Chu, King-Wai; Byne, William; Hazlett, Erin A.] James J Peters VA Med Ctr, VISN Mental Illness Res Educ & Clin Ctr 3, Bronx, NY 10468 USA. [Buchsbaum, Monte S.] Univ Calif San Diego, San Diego Sch Med, Dept Psychiat, La Jolla, CA 92093 USA. [Buchsbaum, Monte S.] Univ Calif San Diego, San Diego Sch Med, Dept Radiol, La Jolla, CA 92093 USA. RP Hazlett, EA (reprint author), Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA. EM erin.hazlett@mssm.edu FU National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH) [UL1TR000067]; NIH [R01MH60023, R01MH56489, R01MH603845]; Eli Lilly and Company; U.S. Department of Veterans Affairs (VA Merit Award) [101CX00026] FX Funding for this study was provided in part by Grants from the National Center for Advancing Translational Sciences (NCATS) (UL1TR000067), a component of the National Institutes of Health (NIH), NIH Grants (R01MH60023, R01MH56489, and R01MH603845 to MSB), Eli Lilly and Company (adolescent MRI and clinical assessment), and the U.S. Department of Veterans Affairs (VA Merit Award 101CX00026 to EAH). NR 60 TC 6 Z9 7 U1 1 U2 5 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0925-4927 EI 1872-7506 J9 PSYCHIAT RES-NEUROIM JI Psychiatry Res. Neuroimaging PD MAR 30 PY 2015 VL 231 IS 3 BP 244 EP 251 DI 10.1016/j.psychresns.2014.12.005 PG 8 WC Clinical Neurology; Neuroimaging; Psychiatry SC Neurosciences & Neurology; Psychiatry GA CD7YE UT WOS:000351311000008 PM 25637358 ER PT J AU Chodos, AH Lee, SJ AF Chodos, Anna H. Lee, Sei J. TI Journalists, district attorneys and researchers: why IRBs should get in the middle SO BMC MEDICAL ETHICS LA English DT Article ID ACCOUNTABILITY AB Background: Federal regulations in the United States have shaped Institutional Review Boards (IRBs) to focus on protecting individual human subjects. Health services research studies focusing on healthcare institutions such as hospitals or clinics do not have individual human subjects. Since U.S. federal regulations are silent on what type of review, if any, these studies require, different IRBs may approach similar studies differently, resulting in undesirable variation in the review of studies focusing on healthcare institutions. Further, although these studies do not focus on individual human subjects, they may pose risks to participating institutions, as well as individuals who work at those institutions, if identifying information becomes public. Discussion: Using two recent health services research studies conducted in the U.S. as examples, we discuss variations in the level of IRB oversight for studies focusing on institutions rather than individual human subjects. We highlight how lack of IRB guidance poses challenges for researchers who wish to both protect their subjects and work appropriately with the public, journalists or the legal system in the U.S. Competing interests include the public's interest in transparency, the researcher's interest in their science, and the research participants' interests in confidentiality. Potential solutions that may help guide health services researchers to balance these competing interests include: 1) creating consensus guidelines and standard practices that address confidentiality risk to healthcare institutions and their employees; and 2) expanding the IRB role to conduct a streamlined review of health services research studies focusing on healthcare institutions to balance the competing interest of stakeholders on a case-by-case basis. Summary: For health services research studies focusing on healthcare institutions, we outline the competing interests of researchers, healthcare institutions and the public. We propose solutions to decrease undesirable variations in the review of these studies. C1 [Chodos, Anna H.] Univ Calif San Francisco, Dept Med, Div Gen Internal Med, San Francisco Gen Hosp, San Francisco, CA 94143 USA. [Chodos, Anna H.; Lee, Sei J.] Univ Calif San Francisco, Div Geriatr, San Francisco, CA 94143 USA. [Chodos, Anna H.; Lee, Sei J.] San Francisco VA Med Ctr, San Francisco, CA USA. RP Chodos, AH (reprint author), Univ Calif San Francisco, Dept Med, Div Gen Internal Med, San Francisco Gen Hosp, 1001 Potrero Ave, San Francisco, CA 94143 USA. EM anna.chodos@ucsf.edu FU National Institute on Aging [T32AG000212-20]; Paul Beeson Career Development Award from the National Institute on Aging [K23AG040779] FX Dr. Chodos was supported by a training grant to the Division of Geriatrics at the University of California, San Francisco from the National Institute on Aging (T32AG000212-20). Dr. Lee was supported through the Paul Beeson Career Development Award from the National Institute on Aging (K23AG040779). NR 6 TC 0 Z9 0 U1 1 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1472-6939 J9 BMC MED ETHICS JI BMC Med. Ethics PD MAR 29 PY 2015 VL 16 AR 19 DI 10.1186/s12910-015-0015-y PG 3 WC Ethics; Medical Ethics; Social Sciences, Biomedical SC Social Sciences - Other Topics; Medical Ethics; Biomedical Social Sciences GA CO8IR UT WOS:000359412300001 PM 25889147 ER PT J AU Yukl, SA Shergill, AK Girling, V Li, QS Killian, M Epling, L Li, PL Kaiser, P Haase, A Havlir, DV McQuaid, K Sinclair, E Wong, JK AF Yukl, Steven A. Shergill, Amandeep K. Girling, Valerie Li, Qingsheng Killian, Maudi Epling, Lorrie Li, Peilin Kaiser, Philipp Haase, Ashley Havlir, Diane V. McQuaid, Kenneth Sinclair, Elizabeth Wong, Joseph K. TI Site-Specific Differences in T Cell Frequencies and Phenotypes in the Blood and Gut of HIV-Uninfected and ART-Treated HIV plus Adults SO PLOS ONE LA English DT Article ID IMMUNODEFICIENCY VIRUS-INFECTION; ACTIVE ANTIRETROVIRAL THERAPY; MUCOSAL IMMUNE RECONSTITUTION; PERIPHERAL-BLOOD; LYMPHOID-TISSUE; GASTROINTESTINAL-TRACT; COLLAGEN DEPOSITION; DISEASE PROGRESSION; POSITIVE PATIENTS; SIV INFECTION AB Gastrointestinal T lymphocytes are critical for mucosal immunity and HIV pathogenesis, yet little is known about normal T cell numbers and phenotypes in different regions of the gut, or the degree to which ART can restore levels to those of HIV-uninfected individuals. To investigate these questions, we measured T cell frequencies and markers of memory, activation, anergy, and homing in the blood, ileum, and rectum of HIV- and ART-suppressed HIV+ adults. In HIV-individuals, T cell frequencies and phenotypes differed significantly between sites. Compared to HIV-adults, HIV+ adults had lower absolute CD4+T cell counts in the ileal lamina propria and lower relative CD4+T cell counts in the blood and ileum. In the gut, HIV+ adults had a higher proportion of CD38+CD4+ T cells, a lower proportion of terminally-differentiated effector cells, and, in the rectum, a higher proportion of CTLA-4+ CD4+T cells. In HIV+ individuals, relative CD4+T cell numbers in the ileum correlated with the proportion of CTLA-4+ CD4+T cells, whereas in the rectum, they tended to correlate with the proportion of circulating CD4+T cells expressing alpha 4 beta 7 or CCR6. Mechanisms of T cell reconstitution may differ throughout the gut, with homing contributing more in the rectum while ileal reconstitution is associated with mucosal CD4+T cell anergy. C1 [Yukl, Steven A.; Shergill, Amandeep K.; Li, Peilin; Kaiser, Philipp; McQuaid, Kenneth; Wong, Joseph K.] San Francisco VA Med Ctr, Dept Med, San Francisco, CA 94121 USA. [Yukl, Steven A.; Shergill, Amandeep K.; Girling, Valerie; Killian, Maudi; Epling, Lorrie; Li, Peilin; Kaiser, Philipp; Havlir, Diane V.; McQuaid, Kenneth; Sinclair, Elizabeth; Wong, Joseph K.] Univ Calif San Francisco, Dept Med, San Francisco, CA USA. [Li, Qingsheng] Univ Nebraska, Sch Biol Sci, Lincoln, NE USA. [Haase, Ashley] Univ Minnesota, Dept Microbiol, Minneapolis, MN 55455 USA. RP Yukl, SA (reprint author), San Francisco VA Med Ctr, Dept Med, San Francisco, CA 94121 USA. EM steven.yukl@ucsf.edu FU U.S. Department of Veterans Affairs [1 IK2 CX000520-01, I01 BX000192]; UCSF-Gladstone Center for AIDS Research (CFAR) [P30-AI027763]; National Institute of Allergy and Infectious Diseases at the National Institutes of Health [R56AI091573, U19AI096109, 1R21AI104445-01A1]; Swiss National Science Foundation [PBZHP3_147260] FX This work was supported by the U.S. Department of Veterans Affairs [1 IK2 CX000520-01 (SY), I01 BX000192 (JW)]; the UCSF-Gladstone Center for AIDS Research (CFAR) [P30-AI027763 (SY)]; the National Institute of Allergy and Infectious Diseases at the National Institutes of Health [R56AI091573 (JW, SY, AS, DH), U19AI096109 (JW), 1R21AI104445-01A1 (PL)]; and the Swiss National Science Foundation [PBZHP3_147260 (PK)]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 49 TC 8 Z9 8 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 26 PY 2015 VL 10 IS 3 AR e0121290 DI 10.1371/journal.pone.0121290 PG 20 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CK6QW UT WOS:000356353700091 PM 25811360 ER PT J AU Smucny, J Visani, A Tregells, JR AF Smucny, Jason Visani, Adrienne Tregells, Jason R. TI Could vagus nerve stimulation target hippocampal hyperactivity to improve cognition in schizophrenia? SO FRONTIERS IN PSYCHIATRY LA English DT Editorial Material DE vagus nerve stimulation; schizophrenia patients; hippocampus; cognition; acetylcholine ID NICOTINIC ACETYLCHOLINE-RECEPTORS; TREATMENT-RESISTANT DEPRESSION; PURSUIT EYE-MOVEMENT; BLOOD-FLOW; PARTIAL EPILEPSY; EPILEPTIFORM ACTIVITY; HEMODYNAMIC-RESPONSE; REFRACTORY EPILEPSY; PREFRONTAL CORTEX; STABLE MEDICATION C1 [Smucny, Jason; Tregells, Jason R.] Univ Colorado, Neurosci Program, Aurora, CO 80045 USA. [Smucny, Jason; Tregells, Jason R.] Denver Vet Affairs Med Ctr, Res Serv, Denver, CO USA. [Smucny, Jason; Visani, Adrienne; Tregells, Jason R.] Univ Colorado, Dept Psychiat, Aurora, CO USA. RP Smucny, J (reprint author), Univ Colorado, Neurosci Program, Anschutz Med Campus, Aurora, CO 80045 USA. EM jason.smucny@ucdenver.edu OI Smucny, Jason/0000-0001-5656-7987 FU CSRD VA [I01 CX000459]; NIDDK NIH HHS [R01 DK089095, R21 DK102052]; NIMH NIH HHS [F31 MH102879, R01 MH102224] NR 85 TC 3 Z9 3 U1 5 U2 8 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1664-0640 J9 FRONT PSYCHIATRY JI Front. Psychiatry PD MAR 24 PY 2015 VL 6 AR 43 DI 10.3389/fpsyt.2015.00043 PG 5 WC Psychiatry SC Psychiatry GA CV4CF UT WOS:000364212300001 PM 25852579 ER PT J AU Neuwelt, EA Schiff, D AF Neuwelt, Edward A. Schiff, David TI Primary CNS lymphoma A landmark trial and the next steps SO NEUROLOGY LA English DT Editorial Material ID WHOLE-BRAIN RADIOTHERAPY; HIGH-DOSE METHOTREXATE; RITUXIMAB; CHEMOTHERAPY; THERAPY C1 [Neuwelt, Edward A.] Oregon Hlth & Sci Univ, Dept Neurol, Portland, OR 97201 USA. [Neuwelt, Edward A.] Oregon Hlth & Sci Univ, Dept Neurosurg, Portland, OR 97201 USA. [Neuwelt, Edward A.] Portland VA Med Ctr, Portland, OR USA. [Schiff, David] Univ Virginia, Neurooncol Ctr, Charlottesville, VA USA. RP Neuwelt, EA (reprint author), Oregon Hlth & Sci Univ, Dept Neurol, Portland, OR 97201 USA. EM neuwelte@ohsu.edu NR 10 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0028-3878 EI 1526-632X J9 NEUROLOGY JI Neurology PD MAR 24 PY 2015 VL 84 IS 12 BP 1194 EP 1195 DI 10.1212/WNL.0000000000001407 PG 2 WC Clinical Neurology SC Neurosciences & Neurology GA CE2RI UT WOS:000351663200008 PM 25716361 ER PT J AU Cohen, DM Ellison, DH AF Cohen, David M. Ellison, David H. TI Evaluating Hyponatremia SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Editorial Material ID WATER C1 [Cohen, David M.; Ellison, David H.] Oregon Hlth & Sci Univ, Div Nephrol & Hypertens, Dept Med, Portland, OR 97239 USA. [Cohen, David M.] Oregon Hlth & Sci Univ, Dept Cell & Dev Biol, Portland, OR 97239 USA. [Cohen, David M.; Ellison, David H.] Portland VA Med Ctr, Portland, OR USA. [Ellison, David H.] Oregon Hlth & Sci Univ, Dept Physiol & Pharmacol, Portland, OR 97239 USA. RP Ellison, DH (reprint author), Oregon Hlth & Sci Univ, Div Nephrol & Hypertens, CH12R,3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA. EM ellisond@ohsu.edu OI Ellison, David/0000-0003-2915-265X FU NIDDK NIH HHS [R01 DK084004] NR 5 TC 0 Z9 1 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD MAR 24 PY 2015 VL 313 IS 12 BP 1260 EP 1261 DI 10.1001/jama.2014.13967 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA CD9RJ UT WOS:000351435500027 PM 25803349 ER PT J AU Singh, JA Ramachandran, R AF Singh, Jasvinder A. Ramachandran, Rekha TI Racial disparities in total ankle arthroplasty utilization and outcomes SO ARTHRITIS RESEARCH & THERAPY LA English DT Article ID TOTAL KNEE ARTHROPLASTY; TOTAL HIP-ARTHROPLASTY; COUNTY OSTEOARTHRITIS PROJECT; PATIENT-REPORTED OUTCOMES; TOTAL JOINT ARTHROPLASTY; INPATIENT SAMPLE NIS; REVISION TOTAL HIP; QUALITY-OF-LIFE; UNITED-STATES; SHOULDER ARTHROPLASTY AB Introduction: The objective of this study was to examine the racial disparities in total ankle arthroplasty (TAA) utilization and outcomes. Methods: We used the National Inpatient Sample (NIS) to study the time-trends. Race was categorized as White and Black. Utilization rates were calculated for the U.S. general population per 100,000. Hospital length of stay, discharge disposition and mortality after TAA were assessed. We used the Cochran Armitage trend test to assess time-trends from 1998 to 2011 and chi-square test to compare TAA utilization. We used analysis of variance or chi-squared test to compare the characteristics of Whites and Blacks undergoing TAA and logistic regression to compare mortality, length of stay and discharge to home versus medical facility. Results: The mean ages for Whites undergoing TAA were 62 years and for Blacks was 52 years. Significant racial disparities were noted in TAA utilization rates (/100,000) in 1998, 0.14 in Whites vs. 0.07 in Blacks (P < 0.0001; 2-fold) and in 2011, 1.17 in Whites vs. 0.33 in Blacks (P < 0.0001; 4-fold). Racial disparities in TAA utilization increased significantly from 1998 to 2011 (P < 0.0001). There was a trend towards statistical significance for the difference in the length of hospital stay in Blacks vs. Whites (52.9% vs. 44.3% with length of hospital stay higher than the median; P = 0.08). Differences in the proportion discharged to an inpatient medical facility after TAA, 16.6% Blacks vs. 13.4% Whites, were not significant (P = 0.36). Conclusions: This study demonstrated significant racial disparities with lower TAA utilization and suboptimal outcomes in Blacks compared to Whites. Further studies are needed to understand the mediators of these disparities and to assess whether these mediators can be targeted to reduce racial disparities in TAA. C1 [Singh, Jasvinder A.] Birmingham VA Med Ctr, Med Serv, Birmingham, AL 35294 USA. [Singh, Jasvinder A.; Ramachandran, Rekha] Univ Alabama Birmingham, Sch Med, Dept Med, Birmingham, AL 35294 USA. [Singh, Jasvinder A.; Ramachandran, Rekha] Univ Alabama Birmingham, Div Epidemiol, Sch Publ Hlth, Birmingham, AL 35294 USA. [Singh, Jasvinder A.] Mayo Clin, Dept Orthoped Surg, Coll Med, Rochester, MN 55905 USA. RP Singh, JA (reprint author), Birmingham VA Med Ctr, Med Serv, Fac Off Tower 805B,510 20th St S, Birmingham, AL 35294 USA. EM jassingh@uab.edu FU Agency for Health Quality and Research Center for Education and Research on Therapeutics (CERTs); National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS); National Institute of Aging; National Cancer Institute FX This material is the result of work supported by the resources and use of facilities at the Birmingham VA Medical Center, AL, USA. JAS is also supported by grants from the Agency for Health Quality and Research Center for Education and Research on Therapeutics (CERTs), the National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS), the National Institute of Aging and the National Cancer Institute. NR 55 TC 1 Z9 1 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1478-6354 EI 1478-6362 J9 ARTHRITIS RES THER JI Arthritis Res. Ther. PD MAR 21 PY 2015 VL 17 AR 70 DI 10.1186/s13075-015-0589-2 PG 8 WC Rheumatology SC Rheumatology GA CF5QE UT WOS:000352611200001 PM 25889569 ER PT J AU Reveles, KR Juday, TR Labreche, MJ Mortensen, EM Koeller, JM Seekins, D Oramasionwu, CU Bollinger, M Copeland, LA Jones, X Frei, CR AF Reveles, Kelly R. Juday, Timothy R. Labreche, Matthew J. Mortensen, Eric M. Koeller, Jim M. Seekins, Daniel Oramasionwu, Christine U. Bollinger, Mary Copeland, Laurel A. Jones, Xavier Frei, Christopher R. TI Comparative Value of Four Measures of Retention in Expert Care in Predicting Clinical Outcomes and Health Care Utilization in HIV Patients SO PLOS ONE LA English DT Article ID ACTIVE ANTIRETROVIRAL THERAPY; QUALITY-OF-LIFE; UNITED-STATES; VETERANS-AFFAIRS; INFECTION; ADHERENCE; ENGAGEMENT; PREVENTION; MORTALITY; ADULTS AB This study compared the ability of four measures of patient retention in HIV expert care to predict clinical outcomes. This retrospective study examined Veterans Health Administration (VHA) beneficiaries with HIV (ICD-9-CM codes 042 or V08) receiving expert care (defined as HIV-1 RNA viral load and CD4 cell count tests occurring within one week of each other) at VHA facilities from October 1, 2006, to September 30, 2008. Patients were >= 18 years old and continuous VHA users for at least 24 months after entry into expert care. Retention measures included: Annual Appointments (>= 2 appointments annually at least 60 days apart), Missed Appointments (missed >= 25% of appointments), Infrequent Appointments (> 6 months without an appointment), and Missed or Infrequent Appointments (missed >= 25% of appointments or > 6 months without an appointment). Multivariable nominal logistic regression models were used to determine associations between retention measures and outcomes. Overall, 8,845 patients met study criteria. At baseline, 64% of patients were virologically suppressed and 37% had a CD4 cell count > 500 cells/mm(3). At 24 months, 82% were virologically suppressed and 46% had a CD4 cell count > 500 cells/mm(3). During follow-up, 13% progressed to AIDS, 48% visited the emergency department (ED), 28% were hospitalized, and 0.3% died. All four retention measures were associated with virologic suppression and antiretroviral therapy initiation at 24 months follow-up. Annual Appointments correlated positively with CD4 cell count > 500 cells/mm(3). Missed Appointments was predictive of all primary and secondary outcomes, including CD4 cell count <= 500 cells/mm(3), progression to AIDS, ED visit, and hospitalization. Missed Appointments was the only measure to predict all primary and secondary outcomes. This finding could be useful to health care providers and public health organizations as they seek ways to optimize the health of HIV patients. C1 [Reveles, Kelly R.; Koeller, Jim M.; Frei, Christopher R.] Univ Texas Austin, Austin, TX 78712 USA. [Reveles, Kelly R.; Koeller, Jim M.; Frei, Christopher R.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Juday, Timothy R.; Seekins, Daniel] Bristol Myers Squibb Co, Plainsboro, NJ USA. [Labreche, Matthew J.] Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA. [Mortensen, Eric M.] VA North Texas Hlth Care Syst, Dallas, TX USA. [Mortensen, Eric M.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA. [Oramasionwu, Christine U.] Univ N Carolina, Chapel Hill, NC USA. [Bollinger, Mary; Jones, Xavier] South Texas Vet Hlth Care Syst, San Antonio, TX USA. [Copeland, Laurel A.] Cent Texas Vet Hlth Care Syst, Temple, TX USA. [Copeland, Laurel A.] Scott & White Healthcare, Ctr Appl Hlth Res, Temple, TX USA. RP Frei, CR (reprint author), Univ Texas Austin, Austin, TX 78712 USA. EM freic@uthscsa.edu OI Mortensen, Eric/0000-0002-3880-5563; Copeland, Laurel/0000-0002-9478-0209 FU Bristol-Myers Squibb Company, Plainsboro, NJ FX This work was supported by Bristol-Myers Squibb Company, Plainsboro, NJ (http://www.bms.com/pages/default.aspx). The funders assisted with the study design and preparation of the manuscript. This work was partially supported with the resources of the Department of Veterans Affairs. The views are those of the authors and do not necessarily reflect the views of the Department of Veterans Affairs. NR 45 TC 2 Z9 2 U1 2 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 20 PY 2015 VL 10 IS 3 AR e0120953 DI 10.1371/journal.pone.0120953 PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CE8HY UT WOS:000352083900092 PM 25794182 ER PT J AU Liu, YY Ayers, S Milanesi, A Teng, XC Rabi, S Akiba, Y Brent, GA AF Liu, Yan-Yun Ayers, Stephen Milanesi, Anna Teng, Xiaochun Rabi, Sina Akiba, Ysutada Brent, Gregory A. TI Thyroid Hormone Receptor Sumoylation Is Required for Preadipocyte Differentiation and Proliferation SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article DE Adipogenesis; Cell Proliferation; Peroxisome Proliferator-activated Receptor (PPAR); Sumoylation; Wnt Signaling; 3T3L1; Human Primary Preadipocytes; NCoR; Perilipin1; TR ID PPAR-GAMMA; IN-VIVO; ADIPOCYTE DIFFERENTIATION; TRANSCRIPTIONAL REGULATION; LIPID DROPLETS; SUMO CHAINS; NUCLEAR RECEPTOR; PERILIPIN-GENE; STEM-CELLS; ALPHA-GENE AB Background: Thyroid hormone receptor (TR) sumoylation is essential for thyroid hormone regulation of gene expression. Results: TR sumoylation mutants impair differentiation though down-regulation of C/EBPs, constitutive interaction with NCoR, interference with PPAR signaling, and disruption of the Wnt canonical signaling pathway important for preadipocyte proliferation. Conclusion: TR sumoylation site mutations impair preadipocyte proliferation and differentiation. Significance: TR sumoylation is required for adipogenesis. Thyroid hormone and thyroid hormone receptor (TR) play an essential role in metabolic regulation. However, the role of TR in adipogenesis has not been established. We reported previously that TR sumoylation is essential for TR-mediated gene regulation and that mutation of either of the two sites in TR or any of the three sites in TR reduces TR sumoylation. Here, we transfected TR sumoylation site mutants into human primary preadiocytes and the mouse 3T3L1 preadipocyte cell line to determine the role of TR sumoylation in adipogenesis. Reduced sumoylation of TR or TR resulted in fewer and smaller lipid droplets and reduced proliferation of preadipocytes. TR sumoylation mutations, compared with wild-type TR, results in reduced C/EBP expression and reduced PPAR(2) mRNA and protein levels. TR sumoylation mutants recruited NCoR and disrupted PPAR-mediated perilipin1 (Plin1) gene expression, associated with impaired lipid droplet formation. Expression of NCoRID, a mutant NCoR lacking the TR interaction domain, partially rescued the delayed adipogenesis and restored Plin1 gene expression and adipogenesis. TR sumoylation site mutants impaired Wnt/-catenin signaling pathways and the proliferation of primary human preadipocytes. Expression of the TR K146Q sumoylation site mutant down-regulated the essential genes required for canonical Wnt signal-mediated proliferation, including Wnt ligands, Fzds, -catenin, LEF1, and CCND1. Additionally, the TR K146Q mutant enhanced the canonical Wnt signaling inhibitor Dickkopf-related protein 1 (DKK1). Our data demonstrate that TR sumoylation is required for activation of the Wnt canonical signaling pathway during preadipocyte proliferation and enhances the PPAR signaling that promotes differentiation. C1 [Liu, Yan-Yun; Milanesi, Anna; Rabi, Sina; Akiba, Ysutada; Brent, Gregory A.] Vet Affairs Greater Los Angeles Healthcare Syst, Mol Endocrinol Lab, Los Angeles, CA 90073 USA. [Liu, Yan-Yun; Milanesi, Anna; Rabi, Sina; Akiba, Ysutada; Brent, Gregory A.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90073 USA. [Liu, Yan-Yun; Milanesi, Anna; Rabi, Sina; Akiba, Ysutada; Brent, Gregory A.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Physiol, Los Angeles, CA 90073 USA. [Ayers, Stephen] Methodist Hosp, Res Inst, Genom Med Program, Houston, TX 77030 USA. [Teng, Xiaochun] China Med Univ, Inst Endocrinol, Shenyang 110001, Peoples R China. RP Liu, YY (reprint author), VA Greater Los Angeles Healthcare Syst, Bldg 114,Rm 230,11301 Wilshire Blvd, Los Angeles, CA 90073 USA. EM yyl@ucla.edu; gbrent@ucla.edu FU National Institutes of Health [R01DK098576] FX This research was supported, in whole or in part, by National Institutes of Health Grant R01DK098576 (to G. A. B.). NR 67 TC 4 Z9 4 U1 1 U2 2 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 EI 1083-351X J9 J BIOL CHEM JI J. Biol. Chem. PD MAR 20 PY 2015 VL 290 IS 12 BP 7402 EP 7415 DI 10.1074/jbc.M114.600312 PG 14 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA CE2AC UT WOS:000351613600009 PM 25572392 ER PT J AU Rockey, DC Bell, PD Hill, JA AF Rockey, Don C. Bell, P. Darwin Hill, Joseph A. TI Fibrosis - A Common Pathway to Organ Injury and Failure SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Review ID IDIOPATHIC-PULMONARY-FIBROSIS; CHRONIC HEPATITIS-C; CARDIOVASCULAR MAGNETIC-RESONANCE; NEPHROGENIC SYSTEMIC FIBROSIS; CONTROLLED CLINICAL-TRIAL; PLACEBO-CONTROLLED TRIAL; CHRONIC KIDNEY-DISEASE; RENAL FIBROSIS; CARDIAC FIBROSIS; MESENCHYMAL TRANSITION C1 [Rockey, Don C.; Bell, P. Darwin] Med Univ S Carolina, Dept Internal Med, Charleston, SC 29425 USA. [Bell, P. Darwin] Ralph H Johnson Vet Affairs Med Ctr, Charleston, SC USA. [Hill, Joseph A.] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA. [Hill, Joseph A.] Univ Texas SW Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA. RP Rockey, DC (reprint author), Med Univ S Carolina, Dept Internal Med, 96 Jonathan Lucas St,Suite 803,MSC 623, Charleston, SC 29425 USA. EM rockey@musc.edu NR 102 TC 90 Z9 95 U1 9 U2 43 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD MAR 19 PY 2015 VL 372 IS 12 BP 1138 EP 1149 DI 10.1056/NEJMra1300575 PG 12 WC Medicine, General & Internal SC General & Internal Medicine GA CD6EZ UT WOS:000351183600008 PM 25785971 ER PT J AU Wilhelm, CJ Hashimoto, JG Roberts, ML Bloom, SH Beard, DK Wiren, KM AF Wilhelm, Clare J. Hashimoto, Joel G. Roberts, Melissa L. Bloom, Shelley H. Beard, Douglas K. Wiren, Kristine M. TI Females uniquely vulnerable to alcohol-induced neurotoxicity show altered glucocorticoid signaling SO BRAIN RESEARCH LA English DT Article DE Alcohol; Neurodegeneration; Glucocorticoid signaling; Neurotoxicity; Astrocyte ID TISSUE GROWTH-FACTOR; ANTERIOR CINGULATE CORTEX; HIPPOCAMPAL SLICE CULTURES; NF-KAPPA-B; SEX-DIFFERENCES; ETHANOL WITHDRAWAL; GENDER-DIFFERENCES; PREFRONTAL CORTEX; GENE-EXPRESSION; LIVER-DISEASE AB Women are more sensitive to the harmful effects of alcohol (EtOH) abuse than men, yet the underlying mechanisms remain poorly understood. Previous gene expression analysis of the medial prefrontal cortex (mPFC) following a chronic intoxication paradigm using continuous 72 h vapor inhalation found that females, but not males, exhibit an inflammatory response at peak withdrawal that is associated with cell damage. Given that glucocorticoids can function as anti-inflammatories, are known to increase with EtOH exposure, and influence neurotoxicity, we hypothesized that males and females may exhibit an altered corticosterone (CORT) response following chronic intoxication. Analysis of serum CORT levels revealed the expected increase during withdrawal with no difference between males and females, while control males but not females exhibited higher CORT concentrations than naive animals. Glucocorticoid signaling characterized using focused qPCR arrays identified a sexually dimorphic response in the mPFC during withdrawal, particularly among astrocyte-enriched genes. These genes include aquaporin-1 (Aqp1), sphingosine kinase 1 (Sphk1) and connective tissue growth factor (Ctgf); genes associated with inflammatory signaling, and tissue damage and repair. Bioinformatic analysis also revealed activation of inflammatory signaling and cell death pathways in females. Confirmation studies showed that female mice exhibited significant neuronal degeneration within the anterior cingulate cortex (ACC). By contrast, EtOH exposure lead to a significant reduction in cell death in males. Thus, distinct glucocorticoid signaling pathways are associated with sexually dimorphic neurotoxicity, suggesting one mechanism by which EtOH-exposed females are particularly vulnerable to the damaging effects of alcohol in the CNS. Published by Elsevier B.V. C1 [Wilhelm, Clare J.; Hashimoto, Joel G.; Roberts, Melissa L.; Bloom, Shelley H.; Beard, Douglas K.; Wiren, Kristine M.] VA Portland Hlth Care Syst, Portland, OR 97239 USA. [Wilhelm, Clare J.] Oregon Hlth & Sci Univ, Dept Psychiat, Portland, OR 97239 USA. [Hashimoto, Joel G.; Wiren, Kristine M.] Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97239 USA. RP Wilhelm, CJ (reprint author), Portland VA Med Ctr, R&D 17, 3710 SW US Vet Hosp Rd, Portland, OR 97239 USA. EM wilhelmc@ohsu.edu FU United States (U.S.) Department of Veterans Affairs Biomedical Laboratory Research and Development [I01 BX001172, IK2 BX001294]; NIH/NIAAA [R01AA021468]; NIAAA [P60AA010760, R24AA020245] FX This research was supported by Merit Review Award #I01 BX001172 (K.M.W.) and Career Development Award #IK2 BX001294 (C.J.W.) from the United States (U.S.) Department of Veterans Affairs Biomedical Laboratory Research and Development and from the NIH/NIAAA (R01AA021468 (K.M.W.)). Additionally, this material is the result of work supported with resources and the use of facilities at the Portland VA Medical Center (K.M.W.) and the Research Career Scientist Program (K.M.W.). We thank Melissa Andrew for assistance with the vapor exposure procedure and acknowledge support from NIAAA for the Portland Alcohol Research Center (P60AA010760) and for the maintenance of colonies of WSR and WSP mice (R24AA020245) used in the present studies. The contents do not represent the views of the U.S. Department of Veterans Affairs or the United States Government. NR 132 TC 4 Z9 5 U1 2 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0006-8993 EI 1872-6240 J9 BRAIN RES JI Brain Res. PD MAR 19 PY 2015 VL 1601 BP 102 EP 116 DI 10.1016/j.brainres.2015.01.002 PG 15 WC Neurosciences SC Neurosciences & Neurology GA CD2TD UT WOS:000350931000011 PM 25601008 ER PT J AU Wynn, JK Roach, BJ Lee, J Horan, WP Ford, JM Jimenez, AM Green, MF AF Wynn, Jonathan K. Roach, Brian J. Lee, Junghee Horan, William P. Ford, Judith M. Jimenez, Amy M. Green, Michael F. TI EEG Findings of Reduced Neural Synchronization during Visual Integration in Schizophrenia SO PLOS ONE LA English DT Article ID GESTALT PERCEPTION; ILLUSORY CONTOURS; BIPOLAR DISORDER; CORTEX; INTERNEURONS; COMPLETION; MODULATION; FREQUENCY; RESPONSES; COGNITION AB Schizophrenia patients exhibit well-documented visual processing deficits. One area of disruption is visual integration, the ability to form global objects from local elements. However, most studies of visual integration in schizophrenia have been conducted in the context of an active attention task, which may influence the findings. In this study we examined visual integration using electroencephalography (EEG) in a passive task to elucidate neural mechanisms associated with poor visual integration. Forty-six schizophrenia patients and 30 healthy controls had EEG recorded while passively viewing figures comprised of real, illusory, or no contours. We examined visual P100, N100, and P200 event-related potential (ERP) components, as well as neural synchronization in the gamma (30-60 Hz) band assessed by the EEG phase locking factor (PLF). The N100 was significantly larger to illusory vs. no contour, and illusory vs. real contour stimuli while the P200 was larger only to real vs. illusory stimuli; there were no significant interactions with group. Compared to controls, patients failed to show increased phase locking to illusory versus no contours between 40-60 Hz. Also, controls, but not patients, had larger PLF between 30-40 Hz when viewing real vs. illusory contours. Finally, the positive symptom factor of the BPRS was negatively correlated with PLF values between 40-60 Hz to illusory stimuli, and with PLF between 30-40 Hz to real contour stimuli. These results suggest that the pattern of results across visual processing conditions is similar in patients and controls. However, patients have deficits in neural synchronization in the gamma range during basic processing of illusory contours when attentional demand is limited. C1 [Wynn, Jonathan K.; Lee, Junghee; Horan, William P.; Jimenez, Amy M.; Green, Michael F.] Vet Affairs Greater Los Angeles Healthcare Syst, Los Angeles, CA 90073 USA. [Wynn, Jonathan K.; Lee, Junghee; Horan, William P.; Green, Michael F.] Univ Calif Los Angeles, Psychiat & Biobehav Sci, Los Angeles, CA USA. [Roach, Brian J.; Ford, Judith M.] Vet Affairs San Francisco Med Ctr, San Francisco, CA USA. [Ford, Judith M.] Univ Calif San Francisco, San Francisco, CA 94143 USA. RP Wynn, JK (reprint author), Vet Affairs Greater Los Angeles Healthcare Syst, Los Angeles, CA 90073 USA. EM jkwynn@ucla.edu RI Lee, Junghee/C-5226-2014; Wynn, Jonathan/H-3749-2014 OI Lee, Junghee/0000-0001-9567-8700; Wynn, Jonathan/0000-0002-1763-8540 FU VA Career Development Award; NIMH [MH43292, MH065707] FX Support for this study came from a VA Career Development Award to Jonathan K. Wynn, Ph.D., and NIMH Grants MH43292 and MH065707 (PI: Michael F. Green, Ph.D). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 45 TC 2 Z9 2 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 18 PY 2015 VL 10 IS 3 AR e0119849 DI 10.1371/journal.pone.0119849 PG 16 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CE9BN UT WOS:000352138500134 PM 25785939 ER PT J AU French, B Small, DS Novak, J Saulsgiver, KA Harhay, MO Asch, DA Volpp, KG Halpern, SD AF French, Benjamin Small, Dylan S. Novak, Julie Saulsgiver, Kathryn A. Harhay, Michael O. Asch, David A. Volpp, Kevin G. Halpern, Scott D. TI Preference-adaptive randomization in comparative effectiveness studies SO TRIALS LA English DT Article DE Adaptive design; Adherence; Comparative effectiveness research; Efficacy; Instrumental variables ID CONTROLLED CLINICAL-TRIAL; PLAY-WINNER RULE; FINANCIAL INCENTIVES; DESIGNS AB Background: Determination of comparative effectiveness in a randomized controlled trial requires consideration of an intervention's comparative uptake (or acceptance) among randomized participants and the intervention's comparative efficacy among participants who use their assigned intervention. If acceptance differs across interventions, then simple randomization of participants can result in post-randomization losses that introduce bias and limit statistical power. Methods: We develop a novel preference-adaptive randomization procedure in which the allocation probabilities are updated based on the inverse of the relative acceptance rates among randomized participants in each arm. In simulation studies, we determine the optimal frequency with which to update the allocation probabilities based on the number of participants randomized. We illustrate the development and application of preference-adaptive randomization using a randomized controlled trial comparing the effectiveness of different financial incentive structures on prolonged smoking cessation. Results: Simulation studies indicated that preference-adaptive randomization performed best with frequent updating, accommodated differences in acceptance across arms, and performed well even if the initial values for the allocation probabilities were not equal to their true values. Updating the allocation probabilities after randomizing each participant minimized imbalances in the number of accepting participants across arms over time. In the smoking cessation trial, unexpectedly large differences in acceptance among arms required us to limit the allocation of participants to less acceptable interventions. Nonetheless, the procedure achieved equal numbers of accepting participants in the more acceptable arms, and balanced the characteristics of participants across assigned interventions. Conclusions: Preference-adaptive randomization, coupled with analysis methods based on instrumental variables, can enhance the validity and generalizability of comparative effectiveness studies. In particular, preference-adaptive randomization augments statistical power by maintaining balanced sample sizes in efficacy analyses, while retaining the ability of randomization to balance covariates across arms in effectiveness analyses. C1 [French, Benjamin; Saulsgiver, Kathryn A.; Harhay, Michael O.; Halpern, Scott D.] Univ Penn, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA. [Small, Dylan S.; Novak, Julie] Univ Penn, Dept Stat, Philadelphia, PA 19104 USA. [Asch, David A.; Volpp, Kevin G.; Halpern, Scott D.] Univ Penn, Dept Med, Philadelphia, PA 19104 USA. [Asch, David A.; Volpp, Kevin G.] Univ Penn, Dept Hlth Care Management, Philadelphia, PA 19104 USA. [Asch, David A.; Volpp, Kevin G.; Halpern, Scott D.] Univ Penn, Dept Med Eth & Hlth Policy, Philadelphia, PA 19104 USA. [Asch, David A.; Volpp, Kevin G.] Philadelphia Vet Affairs Med Ctr, Ctr Hlth Equ Res & Promot, Philadelphia, PA 19104 USA. RP French, B (reprint author), Univ Penn, Dept Biostat & Epidemiol, 423 Guardian Dr, Philadelphia, PA 19104 USA. EM bcfrench@upenn.edu OI Harhay, Michael/0000-0002-0553-674X FU National Institutes of Health [R01-CA159932, RC2-AG036592] FX This work was supported by the National Institutes of Health (grant numbers R01-CA159932 and RC2-AG036592), which had no role in design; in the collection, analysis or interpretation of data; in the writing of the manuscript; or in the decision to submit the manuscript for publication. NR 27 TC 3 Z9 3 U1 3 U2 7 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1745-6215 J9 TRIALS JI Trials PD MAR 18 PY 2015 VL 16 AR 99 DI 10.1186/s13063-015-0592-6 PG 9 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA CF0XL UT WOS:000352267700001 PM 25887045 ER PT J AU Bollinger, MJ Schmidt, S Pugh, JA Parsons, HM Copeland, LA Pugh, MJ AF Bollinger, Mary J. Schmidt, Susanne Pugh, Jacqueline A. Parsons, Helen M. Copeland, Laurel A. Pugh, Mary Jo TI Erosion of the healthy soldier effect in veterans of US military service in Iraq and Afghanistan SO POPULATION HEALTH METRICS LA English DT Article DE Veterans/statistics & numerical data; Mortality; Healthy soldier effect ID PERSIAN-GULF-WAR; RISK-FACTORS; MORTALITY; DEPLOYMENT; DISABILITY; CONFLICT; SUICIDE; RATIOS AB Background: This research explores the healthy soldier effect (HSE) - a lower mortality risk among veterans relative to the general population-in United States (US) veterans deployed in support of operations in Iraq and Afghanistan (OEF/OIF/OND). While a HSE has been affirmed in other OEF/OIF/OND populations, US veterans of OEF/OIF/OND have not been systematically studied. Methods: Using US Department of Veterans Affairs (VA) administrative data, we identified veterans who (1) had been deployed in support of OEF/OIF/OND between 2002 and 2011 and (2) were enrolled in the VA health care system. We divided the VA population into VA health care utilizers and non-utilizers. We obtained Department of Defense (DOD) administrative data on the OEF/OIF/OND population and obtained VA and DOD mortality data excluding combat deaths from the analyses. Indirect standardization was used to compare VA and DOD cohorts to the US population using total population at risk to compute the Standardized Mortality Ratio (SMR). A directly standardized relative risk (DSRR) was calculated to enable comparisons between cohorts. To compare VA enrollee mortality on military specific characteristics, we used a DOD population standard. Results: The overall VA SMR of 2.8 (95% Confidence Interval [CI] 2.8-2.9), VA utilizer SMR of 3.2 (95% CI 3.1-3.3), VA non-utilizer SMR of 0.9 (95% CI 0.8-1.1), and DOD SMR of 1.5 (95% CI 1.4-1.5) provide no evidence of a HSE in any cohort relative to the US standard population. Relative to DOD, both the total VA population SMR of 2.1 (95% CI 2.0-2.2) and the SMR for VA utilizers of 2.3 (95% CI 2.3-2.4) indicate mortality twice what would be expected given DOD mortality rates. In contrast, the VA enrollees who had not used clinical services had 40% lower than expected mortality relative to DOD. Conclusions: No support was found for the HSE among US veterans of OEF/OIF/OND. These findings may be attributable to a number of factors including post-deployment risk-taking behavior, an abbreviated follow up period, and the nature of the OEF/OIF/OND conflict. C1 [Bollinger, Mary J.; Pugh, Jacqueline A.; Pugh, Mary Jo] South Texas Vet Hlth Care Syst, San Antonio, TX 78284 USA. [Bollinger, Mary J.; Pugh, Jacqueline A.] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, Div Hosp Med, San Antonio, TX 78229 USA. [Schmidt, Susanne; Parsons, Helen M.; Pugh, Mary Jo] Univ Texas Hlth Sci Ctr San Antonio, Dept Epidemiol & Biostat, San Antonio, TX 78229 USA. [Copeland, Laurel A.] Cent Texas Vet Hlth Care Syst, Dept Vet Affairs, Temple, TX 76504 USA. [Copeland, Laurel A.] Baylor Scott & White Hlth, Ctr Appl Hlth Res, Temple, TX 76502 USA. RP Bollinger, MJ (reprint author), South Texas Vet Hlth Care Syst, 7400 Merton Minter Blvd, San Antonio, TX 78284 USA. EM bollinger@uthscsa.edu OI Pugh, Jacqueline/0000-0003-4933-141X; Copeland, Laurel/0000-0002-9478-0209 FU Department of Veterans Affairs, Veterans Administration, Office of Research and Development, VA Health Services Research and Development Service [DHI 09-237]; South Texas Veterans Health care System/Audie L. Murphy Division FX This material is based upon work supported by the Department of Veterans Affairs, Veterans Administration, Office of Research and Development, VA Health Services Research and Development Service (DHI 09-237; Dr. MJ Pugh PI). The funding agency had no role in data collection, analysis, or manuscript development. The authors acknowledge and appreciate support from the South Texas Veterans Health care System/Audie L. Murphy Division. The views expressed in this article are those of the authors and do not necessarily represent the views of the Department of Veterans Affairs. NR 34 TC 3 Z9 3 U1 0 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1478-7954 J9 POPUL HEALTH METR JI Popul. Health Metr. PD MAR 18 PY 2015 VL 13 AR 8 DI 10.1186/s12963-015-0040-6 PG 12 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CD7MA UT WOS:000351273300001 PM 25798075 ER PT J AU Shekelle, P Holty, JEC Denberg, TD Qaseem, A AF Shekelle, Paul Holty, Jon-Erik C. Denberg, Thomas D. Qaseem, Amir TI Diagnosis of Obstructive Sleep Apnea in Adults RESPONSE SO ANNALS OF INTERNAL MEDICINE LA English DT Letter C1 [Shekelle, Paul] Greater Los Angeles Vet Affairs Hlth Ctr, Los Angeles, CA 90073 USA. [Shekelle, Paul] RAND Corp, Los Angeles, CA USA. [Holty, Jon-Erik C.] Stanford Univ, Stanford, CA 94305 USA. [Denberg, Thomas D.] Caril Clin, Roanoke, VA USA. [Qaseem, Amir] Amer Coll Physicians, Philadelphia, PA USA. RP Shekelle, P (reprint author), Greater Los Angeles Vet Affairs Hlth Ctr, Los Angeles, CA 90073 USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 USA SN 0003-4819 EI 1539-3704 J9 ANN INTERN MED JI Ann. Intern. Med. PD MAR 17 PY 2015 VL 162 IS 6 BP 456 EP 457 DI 10.7326/L15-5062-3 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA CD7OH UT WOS:000351279600023 PM 25775323 ER PT J AU Filley, CM Bernick, C AF Filley, Christopher M. Bernick, Charles TI Children and football A cautionary tale SO NEUROLOGY LA English DT Editorial Material ID TRAUMATIC BRAIN-INJURY; NEUROPATHOLOGY AB As even any casual American sports enthusiast can attest, the football season occupies a special position in the popular imagination. Fans flock to stadiums and televisions to watch their teams perform in this increasingly violent contact sport, and among these fans, children may come to idolize star players and be almost irresistibly drawn to the gridiron. Parents and coaches may also exert substantial pressure on children to take up the sport. Whereas the benefits of physical exercise are undeniable for the promotion of cardiovascular health and psychological well-being, participation in football may result in neurologic sequelae ranging from mild traumatic brain injury (mTBI)(1) to death,(2) and repetitive mTBI has been associated with a degenerative dementia in later life known as chronic traumatic encephalopathy (CTE).(3) Football has the highest injury rate among team sports, and given that 70% of all football players in the United States are under the age of 14 and that every child aged 9-12 can be exposed to 240 head impacts during a single football season,(4) a better understanding of neurobehavioral sequelae among children who play football is urgently needed. Wide gaps exist in our knowledge, but an area of particularly limited information is the long-term outcome of repetitive mTBI among children in whom recovery from the acute event was apparently complete. C1 [Filley, Christopher M.] Univ Colorado, Sch Med, Dept Psychiat, Aurora, CO 80045 USA. [Filley, Christopher M.] Univ Colorado, Sch Med, Dept Neurol, Aurora, CO USA. [Filley, Christopher M.] Denver Vet Affairs Med Ctr, Denver, CO USA. [Bernick, Charles] Cleveland Clin, Lou Ruvo Ctr Brain Hlth, Cleveland, OH 44106 USA. RP Filley, CM (reprint author), Univ Colorado, Sch Med, Dept Psychiat, Aurora, CO 80045 USA. EM Christopher.filley@ucdenver.edu NR 10 TC 1 Z9 1 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0028-3878 EI 1526-632X J9 NEUROLOGY JI Neurology PD MAR 17 PY 2015 VL 84 IS 11 BP 1068 EP 1069 DI 10.1212/WNL.0000000000001357 PG 2 WC Clinical Neurology SC Neurosciences & Neurology GA CD9YU UT WOS:000351458600005 PM 25632092 ER PT J AU Friedman, MJ AF Friedman, Matthew J. TI Risk Factors for Suicides Among Army Personnel SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Editorial Material ID RESILIENCE; STARRS; PREVALENCE; SOLDIERS; CARE AB IMPORTANCE The Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS) is a multicomponent study designed to generate actionable recommendations to reduce Army suicides and increase knowledge of risk and resilience factors for suicidality. OBJECTIVES To present data on prevalence, trends, and basic sociodemographic and Army experience correlates of suicides and accident deaths among active duty Regular Army soldiers between January 1, 2004, and December 31, 2009, and thereby establish a foundation for future Army STARRS investigations. DESIGN, SETTING, AND PARTICIPANTS Analysis of trends and predictors of suicide and accident deaths using Army and Department of Defense administrative data systems. Participants were all members of the US Regular Army serving at any time between 2004 and 2009. MAIN OUTCOMES AND MEASURES Death by suicide or accident during active Army service. RESULTS The suicide rate rose between 2004 and 2009 among never deployed and currently and previously deployed Regular Army soldiers. Increased suicide risk was associated with being a man (or a woman during deployment), white race/ethnicity, junior enlisted rank, recent demotion, and current or previous deployment. Sociodemographic and Army experience predictors were generally similar for suicides and accident deaths. CONCLUSION Predictors of Army suicides were largely similar to those reported elsewhere for civilians, although some predictors distinct to Army service emerged that deserve more in-depth analysis. The existence of a time trend in suicide risk among never-deployed soldiers argues indirectly against the view that exposure to combat-related trauma is the exclusive cause of the increase in Army suicides. C1 [Friedman, Matthew J.] US Dept Vet Affairs, Natl Ctr PTSD, White River Jct, VT USA. [Friedman, Matthew J.] Geisel Sch Med Dartmouth, Dept Psychiat, Hanover, NH USA. [Friedman, Matthew J.] Geisel Sch Med Dartmouth, Dept Pharmacol & Toxicol, Hanover, NH USA. RP Friedman, MJ (reprint author), Natl Ctr PTSD, Dept Vet Affairs, 215 N Main St 116D, White River Jct, VT 05009 USA. EM matthew.friedman@dartmouth.edu NR 8 TC 3 Z9 3 U1 2 U2 8 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD MAR 17 PY 2015 VL 313 IS 11 BP 1154 EP 1155 DI 10.1001/jamapsychiatry.2013.4417 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA CD5BP UT WOS:000351102500017 PM 25781444 ER PT J AU Barnes, GD Stanislawski, M Baron, AE Armstrong, E Ho, PM Klein, A Maddox, T Nallamothu, B Rumsfeld, J Tsai, T Bradley, S AF Barnes, Geoffrey D. Stanislawski, Maggie Baron, Anna E. Armstrong, Ehrin Ho, P. Michael Klein, Andrew Maddox, Thomas Nallamothu, Brahmajee Rumsfeld, John Tsai, Thomas Bradley, Steven TI USE OF CONTRAINDICATED ANTITHROMBOTIC MEDICATIONS IN THE CARDIAC CATHETERIZATION LABORATORY: INSIGHTS FROM THE VETERANS AFFAIRS CLINICAL ASSESSMENT, REPORTING, AND TRACKING PROGRAM SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Meeting Abstract CT Scientific Session of the American-College-of-Cardiology (ACC) CY MAR 14-16, 2015 CL San Diego, CA SP Amer Coll Cardiol C1 Univ Michigan, Frankel Cardiovasc Ctr, Ann Arbor, MI 48109 USA. Denver VA Med Ctr, Denver, CO USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 EI 1558-3597 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD MAR 17 PY 2015 VL 65 IS 10 SU S MA 915-04 BP A2159 EP A2159 PG 1 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA DL0ND UT WOS:000375328802481 ER PT J AU Le, DTE Wei, K Zhao, Y Nugent, M Belardinelli, L Kaul, S AF Dai-Trang Elizabeth Le Wei, Kevin Zhao, Yan Nugent, Matthew Belardinelli, Luiz Kaul, Sanjiv TI INTRAVENOUS RANOLAZINE RELIEVES ISCHEMIA BY INCREASING MYOCARDIAL ADENOSINE LEVELS SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Meeting Abstract CT Scientific Session of the American-College-of-Cardiology (ACC) CY MAR 14-16, 2015 CL San Diego, CA SP Amer Coll Cardiol C1 Portland VA Med Ctr, Portland, OR USA. Oregon Hlth & Sci Univ, Knight Cardiovasc Inst, Portland, OR 97201 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 EI 1558-3597 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD MAR 17 PY 2015 VL 65 IS 10 SU S MA 1133M-09 BP A1571 EP A1571 PG 1 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA DL0ND UT WOS:000375328801891 ER PT J AU Schopfer, DW Rush, KM Rohrbach, G Hasara, S Bettencourt, M Pabst, MS Whooley, M AF Schopfer, David W. Rush, Kimberly M. Rohrbach, Greg Hasara, Stephanie Bettencourt, Michael Pabst, Mark S. Whooley, Mary TI THE HEALTHY HEART CARDIAC REHABILITATION PROGRAM SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Meeting Abstract CT Scientific Session of the American-College-of-Cardiology (ACC) CY MAR 14-16, 2015 CL San Diego, CA SP Amer Coll Cardiol C1 [Schopfer, David W.; Rush, Kimberly M.; Rohrbach, Greg; Hasara, Stephanie; Bettencourt, Michael; Pabst, Mark S.; Whooley, Mary] San Francisco VA Med Ctr, San Francisco, CA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 EI 1558-3597 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD MAR 17 PY 2015 VL 65 IS 10 SU S MA 1212-131 BP A1493 EP A1493 PG 1 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA DL0ND UT WOS:000375328801813 ER PT J AU Trieu, L Zamani, P Doulias, PT Rawat, D Kumar, PS Bhuva, R Vadde, N Dunde, A Soto-Calderon, H Tariq, A Javaheri, A Haines, P Ischiropoulos, H Akers, S Medina, JC AF Trieu, Lien Zamani, Payman Doulias, Paschalis-Thomas Rawat, Deepa Kumar, Prithvi Shiva Bhuva, Rushik Vadde, Neetha Dunde, Anjaneyulu Soto-Calderon, Haideliza Tariq, Ali Javaheri, Ali Haines, Philip Ischiropoulos, Harry Akers, Scott Medina, Julio Chirinos TI PLASMA LEVELS OF NITRIC OXIDE METABOLITES ARE LOWER IN HFPEF SUBJECTS COMPARED TO HFREF AND HYPERTENSIVES SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Meeting Abstract CT Scientific Session of the American-College-of-Cardiology (ACC) CY MAR 14-16, 2015 CL San Diego, CA SP Amer Coll Cardiol C1 Univ Penn, Philadelphia, PA 19104 USA. Philadelphia VA Med Ctr, Philadelphia, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 EI 1558-3597 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD MAR 17 PY 2015 VL 65 IS 10 SU S MA 1113-208 BP A825 EP A825 PG 1 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA DL0ND UT WOS:000375328801145 ER PT J AU Elder, GA Sosa, MAG De Gasperi, R Stone, JR Dickstein, DL Haghighi, F Hof, PR Ahlers, ST AF Elder, Gregory A. Sosa, Miguel A. Gama De Gasperi, Rita Stone, James Radford Dickstein, Dara L. Haghighi, Fatemeh Hof, Patrick R. Ahlers, Stephen T. TI Vascular and inflammatory factors in the pathophysiology of blast-induced brain injury SO FRONTIERS IN NEUROLOGY LA English DT Review DE animal models; blast; inflammation; traumatic brain injury; vascular pathology ID CENTRAL-NERVOUS-SYSTEM; POSTTRAUMATIC-STRESS-DISORDER; CHRONIC TRAUMATIC ENCEPHALOPATHY; MISSILE EXTREMITY IMPACT; PRESSURE WAVE INJURIES; TIME-DEPENDENT CHANGES; NON-PENETRATIVE BLAST; SHOCK-WAVE; RAT MODEL; INDUCED NEUROTRAUMA AB Blast-related traumatic brain injury (TBI) has received much recent attention because of its frequency in the conflicts in Iraq and Afghanistan. This renewed interest has led to a rapid expansion of clinical and animal studies related to blast. In humans, high-level blast exposure is associated with a prominent hemorrhagic component. In animal models, blast exerts a variety of effects on the nervous system including vascular and inflammatory effects that can be seen with even low-level blast exposures which produce minimal or no neuronal pathology. Acutely, blast exposure in animals causes prominent vasospasm and decreased cerebral blood flow along with blood-brain barrier breakdown and increased vascular permeability. Besides direct effects on the central nervous system, evidence supports a role fora thoracically mediated effect of blast; whereby, pressure waves transmitted through the systemic circulation damage the brain. Chronically, a vascular pathology has been observed that is associated with alterations of the vascular extracellular matrix. Sustained microglial and astroglial reactions occur after blast exposure. Markers of a central and peripheral inflammatory response are found for sustained periods after blast injury and include elevation of inflammatory cytokines and other inflammatory mediators. At low levels of blast exposure, a microvascular pathology has been observed in the presence of an otherwise normal brain parenchyma, suggesting that the vasculature may be selectively vulnerable to blast injury. Chronic immune activation in brain following vascular injury may lead to neurobehavioral changes in the absence of direct neuronal pathology. Strategies aimed at preventing or reversing vascular damage or modulating the immune response may improve the chronic neuropsychiatric symptoms associated with blast-related TBI. C1 [Elder, Gregory A.] James J Peters Dept Vet Affairs Med Ctr, Neurol Serv, Bronx, NY 10468 USA. [Elder, Gregory A.; Sosa, Miguel A. Gama; De Gasperi, Rita; Haghighi, Fatemeh] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA. [Elder, Gregory A.] Icahn Sch Med Mt Sinai, Dept Neurol, New York, NY 10029 USA. [Elder, Gregory A.; Sosa, Miguel A. Gama; De Gasperi, Rita; Dickstein, Dara L.; Haghighi, Fatemeh; Hof, Patrick R.] Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA. [Sosa, Miguel A. Gama; De Gasperi, Rita; Haghighi, Fatemeh] James J Peters Dept Vet Affairs Med Ctr, Res & Dev Serv, Bronx, NY 10468 USA. [Stone, James Radford] Univ Virginia, Dept Radiol & Med Imaging, Charlottesville, VA USA. [Stone, James Radford] Univ Virginia, Dept Neurosurg, Charlottesville, VA USA. [Dickstein, Dara L.; Haghighi, Fatemeh; Hof, Patrick R.] Icahn Sch Med Mt Sinai, Fishberg Dept Neurosci, New York, NY 10029 USA. [Dickstein, Dara L.; Hof, Patrick R.] Icahn Sch Med Mt Sinai, Dept Geriatr & Palliat Care, New York, NY 10029 USA. [Ahlers, Stephen T.] Naval Med Res Ctr, Dept Neurotrauma, Operat & Undersea Med Directorate, Silver Spring, MD USA. RP Elder, GA (reprint author), James J Peters Dept Vet Affairs Med Ctr, Neurol Serv, 3E16,130 West Kingsbridge Rd, Bronx, NY 10468 USA. EM gregory.elder@va.gov FU Department of Veterans Affairs; Veterans Health Administration; Rehabilitation Research and Development Service [1I01RX000179-01, 1I01RX000996-01] FX The authors have received research support from the Department of Veterans Affairs, Veterans Health Administration, Rehabilitation Research and Development Service Awards 1I01RX000179-01 and 1I01RX000996-01. The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, nor the U.S. Government. STA is a military service member (or employe of the U.S. Government). This work was prepared as part of his official duties. Title 17 U.S.C. 105 provides that copyright protection under this title is not available for any work of the United States Government. Title 17 U.S.C. 101 defines a U.S. Government work as a work prepared by a military service member or employe of the U.S. Government as part of that person's official duties. NR 147 TC 9 Z9 10 U1 3 U2 7 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1664-2295 J9 FRONT NEUROL JI Front. Neurol. PD MAR 16 PY 2015 VL 6 AR UNSP 48 DI 10.3389/fneur.2015.00048 PG 22 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA CU8CX UT WOS:000363769900001 PM 25852632 ER PT J AU Yancey, DM Guichard, JL Ahmed, MI Zhou, LF Murphy, MP Johnson, MS Benavides, GA Collawn, J Darley-Usmar, V Dell'Italia, LJ AF Yancey, Danielle M. Guichard, Jason L. Ahmed, Mustafa I. Zhou, Lufang Murphy, Michael P. Johnson, Michelle S. Benavides, Gloria A. Collawn, James Darley-Usmar, Victor Dell'Italia, Louis J. TI Cardiomyocyte mitochondrial oxidative stress and cytoskeletal breakdown in the heart with a primary volume overload SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY LA English DT Article DE heart failure; mitochondria; cardiomyocyte ID ISOLATED MITRAL REGURGITATION; MICE LACKING DESMIN; HYPERTROPHIED MYOCARDIUM; CONTRACTILE DYSFUNCTION; EXTRACELLULAR-MATRIX; CARDIAC DYSFUNCTION; SKELETAL MYOPATHY; XANTHINE-OXIDASE; FAILURE; BIOENERGETICS AB Left ventricular (LV) volume overload (VO) results in cardiomyocyte oxidative stress and mitochondrial dysfunction. Because mitochondria are both a source and target of ROS, we hypothesized that the mitochondrially targeted antioxidant mitoubiquinone (MitoQ) will improve cardiomyocyte damage and LV dysfunction in VO. Isolated cardiomyocytes from Sprague-Dawley rats were exposed to stretch in vitro and VO of aortocaval fistula (ACF) in vivo. ACF rats were treated with and without MitoQ. Isolated cardiomyocytes were analyzed after 3 h of cyclical stretch or 8 wk of ACF with MitoSox red or 5-(and-6)-chloromethyl-2',7'-dichlorodihydrofluorescein diacetate to measure ROS and with tetramethylrhodamine to measure mitochondrial membrane potential. Transmission electron microscopy and immunohistochemistry were used for cardiomyocyte structural assessment. In vitro cyclical stretch and 8-wk ACF resulted in increased cardiomyocyte mitochondrial ROS production and decreased mitochondrial membrane potential, which were significantly improved by MitoQ. ACF had extensive loss of desmin and beta(2)-tubulin that was paralleled by mitochondrial disorganization, loss of cristae, swelling, and clustering identified by mitochondria complex IV staining and transmission electron microscopy. MitoQ improved mitochondrial structural damage and attenuated desmin loss/degradation evidenced by immunohistochemistry and protein expression. However, LV dilatation and fractional shortening were unaffected by MitoQ treatment in 8-wk ACF. In conclusion, although MitoQ did not affect LV dilatation or function in ACF, these experiments suggest a connection of cardiomyocyte mitochondria-derived ROS production with cytoskeletal disruption and mitochondrial damage in the VO of ACF. C1 [Dell'Italia, Louis J.] Dept Vet Affairs Med Ctr, Birmingham, AL USA. [Yancey, Danielle M.; Guichard, Jason L.; Ahmed, Mustafa I.; Zhou, Lufang; Dell'Italia, Louis J.] Univ Alabama Birmingham, UAB Comprehens Cardiovasc Ctr, Birmingham, AL USA. [Yancey, Danielle M.; Guichard, Jason L.; Ahmed, Mustafa I.; Zhou, Lufang; Dell'Italia, Louis J.] Univ Alabama Birmingham, Dept Med, Div Cardiovasc Dis, Birmingham, AL 35294 USA. [Johnson, Michelle S.; Benavides, Gloria A.; Darley-Usmar, Victor] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA. [Johnson, Michelle S.; Benavides, Gloria A.; Darley-Usmar, Victor] Univ Alabama Birmingham, UAB Ctr Free Radical Biol, Birmingham, AL USA. [Murphy, Michael P.] MRC, Mitochondrial Biol Unit, Cambridge, England. [Collawn, James] Univ Alabama Birmingham, Dept Cell Dev & Integrat Biol, Birmingham, AL USA. RP Dell'Italia, LJ (reprint author), Birmingham Vet Affairs Med Ctr, 700 S 19th St, Birmingham, AL 35294 USA. EM louis.dellitalia@va.gov FU American Heart Association Predoctoral Fellowship [13PRE14560035]; National Heart, Lung, and Blood Institute Training Grant [5-T32-HL-072757, R01-HL-54816] FX This work was supported by American Heart Association Predoctoral Fellowship 13PRE14560035 (to D. M. Yancey) and National Heart, Lung, and Blood Institute Training Grant 5-T32-HL-072757 (to J. L. Guichard) and Grant R01-HL-54816 (to L. J. Dell'Italia). NR 47 TC 12 Z9 12 U1 0 U2 12 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0363-6135 EI 1522-1539 J9 AM J PHYSIOL-HEART C JI Am. J. Physiol.-Heart Circul. Physiol. PD MAR 15 PY 2015 VL 308 IS 6 BP H651 EP H663 DI 10.1152/ajpheart.00638.2014 PG 13 WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular Disease SC Cardiovascular System & Cardiology; Physiology GA CD3OU UT WOS:000350988900009 PM 25599572 ER PT J AU Mylonakis, E Clancy, CJ Ostrosky-Zeichner, L Garey, KW Alangaden, GJ Vazquez, JA Groeger, JS Judson, MA Vinagre, YM Heard, SO Zervou, FN Zacharioudakis, IM Kontoyiannis, DP Pappas, PG AF Mylonakis, Eleftherios Clancy, Cornelius J. Ostrosky-Zeichner, Luis Garey, Kevin W. Alangaden, George J. Vazquez, Jose A. Groeger, Jeffrey S. Judson, Marc A. Vinagre, Yuka-Marie Heard, Stephen O. Zervou, Fainareti N. Zacharioudakis, Ioannis M. Kontoyiannis, Dimitrios P. Pappas, Peter G. TI T2 Magnetic Resonance Assay for the Rapid Diagnosis of Candidemia in Whole Blood: A Clinical Trial SO CLINICAL INFECTIOUS DISEASES LA English DT Article DE T2 magnetic resonance; T2MR; Candida; fungal infections; clinical trial ID INVASIVE CANDIDIASIS; ECHINOCANDIN RESISTANCE; OPPORTUNISTIC YEAST; ANTIFUNGAL THERAPY; FUNGAL-INFECTIONS; RISK-FACTORS; CULTURE; MANAGEMENT; TIME; FLUCONAZOLE AB Background. Microbiologic cultures, the current gold standard diagnostic method for invasive Candida infections, have low specificity and take up to 2-5 days to grow. We present the results of the first extensive multicenter clinical trial of a new nanodiagnostic approach, T2 magnetic resonance (T2MR), for diagnosis of candidemia. Methods. Blood specimens were collected from 1801 hospitalized patients who had a blood culture ordered for routine standard of care; 250 of them were manually supplemented with concentrations from <1 to 100 colonyforming units (CFUs)/mL for 5 different Candida species. Results. T2MR demonstrated an overall specificity per assay of 99.4% (95% confidence interval [CI], 99.1%-99.6%) with a mean time to negative result of 4.2 +/- 0.9 hours. Subanalysis yielded a specificity of 98.9% (95% CI, 98.3%-99.4%) for Candida albicans/Candida tropicalis, 99.3% (95% CI, 98.7%-99.6%) for Candida parapsilosis, and 99.9% (95% CI, 99.7%-100.0%) for Candida krusei/Candida glabrata. The overall sensitivity was found to be 91.1% (95% CI, 86.9%-94.2%) with a mean time of 4.4 +/- 1.0 hours for detection and species identification. The subgroup analysis showed a sensitivity of 92.3% (95% CI, 85.4%-96.6%) for C. albicans/C. tropicalis, 94.2% (95% CI, 84.1%-98.8%) for C. parapsilosis, and 88.1% (95% CI, 80.2%-93.7%) for C. krusei/C. glabrata. The limit of detection was 1 CFU/mL for C. tropicalis and C. krusei, 2 CFU/mL for C. albicans and C. glabrata, and 3 CFU/mL for C. parapsilosis. The negative predictive value was estimated to range from 99.5% to 99.0% in a study population with 5% and 10% prevalence of candidemia, respectively. Conclusions. T2MR is the first fully automated technology that directly analyzes whole blood specimens to identify species without the need for prior isolation of Candida species, and represents a breakthrough shift into a new era of molecular diagnostics. C1 [Mylonakis, Eleftherios; Zervou, Fainareti N.; Zacharioudakis, Ioannis M.] Brown Univ, Rhode Isl Hosp, Div Infect Dis, Warren Alpert Med Sch, Providence, RI 02903 USA. [Clancy, Cornelius J.] Univ Pittsburgh, Vet Affairs Pittsburgh Healthcare Syst, Div Infect Dis, Pittsburgh, PA 15260 USA. [Ostrosky-Zeichner, Luis] Univ Texas Med Sch Houston, Div Infect Dis, Houston, TX USA. [Ostrosky-Zeichner, Luis] Mem Hermann Texas Med Ctr, Houston, TX USA. [Garey, Kevin W.] Univ Houston, Coll Pharm, Houston, TX 77004 USA. [Alangaden, George J.] Henry Ford Hlth Syst, Div Infect Dis, Detroit, MI USA. [Vazquez, Jose A.] Georgia Regents Univ, Med Coll Georgia, Dept Med, Augusta, GA USA. [Groeger, Jeffrey S.] Mem Sloan Kettering Canc Ctr, Urgent Care Serv, New York, NY 10021 USA. [Judson, Marc A.] Albany Med Coll, Div Pulm & Crit Care Med, New York, NY USA. [Vinagre, Yuka-Marie] St Vincent Hosp, Dept Crit Care Med, Worcester, MA 01604 USA. [Heard, Stephen O.] UMass Mem Med Ctr, Dept Anesthesiol, Worcester, MA USA. [Kontoyiannis, Dimitrios P.] Univ Texas MD Anderson Canc Ctr, Dept Infect Dis Infect Control & Employee Hlth, Houston, TX 77030 USA. [Pappas, Peter G.] Univ Alabama, Div Infect Dis, Birmingham, W Midlands, England. RP Mylonakis, E (reprint author), Brown Univ, Rhode Isl Hosp, Div Infect Dis, Warren Alpert Med Sch, 593 Eddy St,3rd Floor,Ste 328-330, Providence, RI 02903 USA. EM emylonakis@lifespan.org OI Garey, Kevin/0000-0003-2063-7503 FU T2 Biosystems FX This work was supported by T2 Biosystems. NR 39 TC 62 Z9 62 U1 2 U2 10 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD MAR 15 PY 2015 VL 60 IS 6 BP 892 EP 899 DI 10.1093/cid/ciu959 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CD4KP UT WOS:000351051600012 PM 25586686 ER PT J AU Pandit, MM Inscho, EW Zhang, SL Seki, T Rohatgi, R Gusella, L Kishore, B Kohan, DE AF Pandit, Meghana M. Inscho, Edward W. Zhang, Shali Seki, Tsugio Rohatgi, Rajeev Gusella, Luca Kishore, Bellamkonda Kohan, Donald E. TI Flow regulation of endothelin-1 production in the inner medullary collecting duct SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY LA English DT Article DE collecting duct; endothelin; flow; purinergic ID POLYCYSTIC KIDNEY-DISEASE; EPITHELIAL NA+ CHANNEL; ESSENTIAL-HYPERTENSION; URINARY ENDOTHELIN-1; SODIUM RETENTION; PRINCIPAL CELLS; TRPC3 CHANNELS; BLOOD-PRESSURE; PRIMARY CILIUM; SHEAR-STRESS AB Collecting duct-derived endothelin (ET)-1 is an autocrine inhibitor of Na+ and water reabsorption; its deficiency causes hypertension and water retention. Extracellular fluid volume expansion increases collecting duct ET-1, thereby promoting natriuresis and diuresis; however, how this coupling between volume expansion and collecting duct ET-1 occurs is incompletely understood. One possibility is that volume expansion increases tubular fluid flow. To investigate this, cultured IMCD3 cells were subjected to static or flow conditions. Exposure to a shear stress of 2 dyn/cm(2) for 2 h increased ET-1 mRNA content by similar to 2.3-fold. Absence of perfusate Ca2+, chelation of intracellular Ca2+, or inhibition of Ca2+ signaling (calmodulin, Ca2+/calmodulin-dependent kinase, calcineurin, PKC, or phospholipase C) prevented the flow response. Evaluation of possible flow-activated Ca2+ entry pathways revealed no role for transient receptor potential (TRP)C3, TRPC6, and TRPV4; however, cells with TRPP2 (polycystin-2) knockdown had no ET-1 flow response. Flow increased intracellular Ca2+ was blunted in TRPP2 knockdown cells. Nonspecific blockade of P2 receptors, as well as specific inhibition of P2X(7) and P2Y(2) receptors, prevented the ET-1 flow response. The ET-1 flow response was not affected by inhibition of either epithelial Na+ channels or the mitochondrial Na+/Ca2+ exchanger. Taken together, these findings provide evidence that in IMCD3 cells, flow, via polycystin-2 and P2 receptors, engages Ca2+ dependent signaling pathways that stimulate ET-1 synthesis. C1 [Pandit, Meghana M.; Kishore, Bellamkonda; Kohan, Donald E.] Univ Utah, Hlth Sci Ctr, Div Nephrol, Salt Lake City, UT 84132 USA. [Pandit, Meghana M.; Kohan, Donald E.] Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT USA. [Inscho, Edward W.; Zhang, Shali] Univ Alabama Birmingham, Birmingham, AL USA. [Seki, Tsugio] Calif Northstate Univ, Dept Med Educ, Elk Grove, CA USA. [Rohatgi, Rajeev; Gusella, Luca] James J Peter Vet Affairs Med Ctr, Dept Med, Bronx, NY USA. [Rohatgi, Rajeev; Gusella, Luca] Icahn Sch Med Mt Sinai, Dept Med & Pediat, New York, NY 10029 USA. [Kishore, Bellamkonda; Kohan, Donald E.] Salt Lake Vet Affairs Med Ctr, Salt Lake City, UT USA. RP Kohan, DE (reprint author), Univ Utah, Hlth Sci Ctr, Div Nephrol, 1900 E 30 N, Salt Lake City, UT 84132 USA. EM donald.kohan@hsc.utah.edu OI Kishore, Bellamkonda/0000-0001-8232-9827 FU National Institutes of Health (NIH) [P01-HL-095499]; Veterans Affairs Merit Reviews; NIH [DK-044628, HL-098135] FX This work was supported in part by National Institutes of Health (NIH) Grants P01-HL-095499 (to D. E. Kohan and E. W. Inscho), Veterans Affairs Merit Reviews (to R. Rohatgi and to B. Kishore), and NIH Grants DK-044628 and HL-098135 (to E. W. Inscho). NR 57 TC 8 Z9 8 U1 0 U2 4 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 1931-857X EI 1522-1466 J9 AM J PHYSIOL-RENAL JI Am. J. Physiol.-Renal Physiol. PD MAR 15 PY 2015 VL 308 IS 6 BP F541 EP F552 DI 10.1152/ajprenal.00456.2014 PG 12 WC Physiology; Urology & Nephrology SC Physiology; Urology & Nephrology GA CD4NT UT WOS:000351060800004 PM 25587122 ER PT J AU Pietrzak, RH Tsai, J Armour, C Mota, N Harpaz-Rotem, I Southwick, SM AF Pietrzak, Robert H. Tsai, Jack Armour, Cherie Mota, Natalie Harpaz-Rotem, Ilan Southwick, Steven M. TI Functional significance of a novel 7-factor model of DSM-5 PTSD symptoms: Results from the National Health and Resilience in Veterans Study SO JOURNAL OF AFFECTIVE DISORDERS LA English DT Article DE Posttraumatic stress disorder; Veterans; Trauma; Symptomatology; Functioning ID POSTTRAUMATIC-STRESS-DISORDER; QUALITY-OF-LIFE; DEPRESSION; ANXIETY AB Background: While post:traumatic stress disorder (PTSD) symptoms in the recently published Diagnostic. and Statistical Manual of Mental Disorders, Filth Edition (DSM-5) are clustered into four factors, emerging confirmatory factor analytic studies suggest that this disorder is best characterized by seven symptom clusters, including re-experiencing, avoidance, negative affect, anhedonia, externalizing behaviors, and anxious and dysphoric arousal symptoms. To date, however, data are lacking regarding the relation between this novel model of DSM-5 PTSD symptoms and measures of clinical significance in this population (e.g., functioning). Methods: Using data from the National Health and Resilience in Veterans Study (NHRVS), a contemporary, nationally representative sample of 1484 U.S. veterans, we evaluated clinical and functional Correlates of a novel 7-factor model of DSM-5 PTSD symptoms. Results: Differential patterns of associations were observed between DSM-5 PTSD symptom clusters, and psychiatric comorbidities, suicidal ideation, hostility, and functioning and quality of life. Anhedonia symptoms, in particular, were strongly related to current depression, as well as reduced mental Functioning and quality of life. Externalizing behaviors were most strongly related to hostility, supporting the convergent validity of this construct. Limitations: Cross-sectional design and employment of self-report measures. Conclusions: These results suggest that a more refined 7-factor model of DSM-5 PTSD symptoms may provide greater specificity in understanding associations with comorbid psychopathology, suicidal ideation, and functioning and quality of life in US. veterans. They further suggest that prevention and treatment efforts that target distinct aspects of the PTSD phenotype may be more effective in mitigating key clinical and functional outcomes in this population. Published by Elsevier B.V. C1 [Pietrzak, Robert H.; Harpaz-Rotem, Ilan; Southwick, Steven M.] US Dept Vet Affairs, Natl Ctr Posttraumut Stress Disorder, Clin Neurosci Div, VA Connecticut Healthcare Syst, West Haven, CT USA. [Pietrzak, Robert H.; Tsai, Jack; Mota, Natalie; Harpaz-Rotem, Ilan; Southwick, Steven M.] Yale Univ, Dept Psychiat, West Haven, CT 06516 USA. [Tsai, Jack] US Dept Vet Affairs, New England Mental Illness Res Educ & Clin Ctr, West Haven, CT USA. [Armour, Cherie] Univ Ulster, Psychol Res Inst, Coleraine BT52 1SA, Londonderry, North Ireland. RP Pietrzak, RH (reprint author), Yale Univ, Dept Psychiat, 950 Campbell Ave 151E, West Haven, CT 06516 USA. EM robert.pietrzak@yale.edu OI Armour, Cherie/0000-0001-7649-3874 FU U.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder FX The National Health and Resilience in Veterans Study (NHRVS) and preparation of this report was supported by the U.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder and a private donation. NR 22 TC 20 Z9 20 U1 4 U2 26 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-0327 EI 1573-2517 J9 J AFFECT DISORDERS JI J. Affect. Disord. PD MAR 15 PY 2015 VL 174 BP 522 EP 526 DI 10.1016/j.jad.2014.12.007 PG 5 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA CC0CY UT WOS:000350003800071 PM 25556669 ER PT J AU Cadoni, S Falt, P Gallittu, P Liggi, M Mura, D Smajstrla, V Erriu, M Leung, FW AF Cadoni, S. Falt, P. Gallittu, P. Liggi, M. Mura, D. Smajstrla, V. Erriu, M. Leung, F. W. TI COMPARISON OF METHODS FOR LUMINAL DISTENTION FOR ON-DEMAND SEDATION COLONOSCOPY: AIR INSUFFLATION, CARBON DIOXIDE AND WATER-AIDED COLONOSCOPY: A 2-CENTER RANDOMIZED CONTROLLED TRIAL SO DIGESTIVE AND LIVER DISEASE LA English DT Meeting Abstract C1 [Cadoni, S.; Gallittu, P.; Liggi, M.; Mura, D.] S Barbara Hosp, Digest Endoscopy Unit, Iglesias, CI, Italy. [Falt, P.; Smajstrla, V.] Vitkovice Hosp, Ctr Digest Dis, Ostrava, Czech Republic. [Erriu, M.] Univ Cagliari, Dept Surg Sci, Cagliari, Italy. [Leung, F. W.] Vet Affairs Greater Los Angeles Healthcare Syst, Sepulveda Ambulatory Care Ctr, Los Angeles, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1590-8658 EI 1878-3562 J9 DIGEST LIVER DIS JI Dig. Liver Dis. PD MAR 15 PY 2015 VL 47 SU 2 MA OC.02.2 BP E75 EP E76 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA V46MS UT WOS:000209888900018 ER PT J AU Zhu, W Dotson, AL Libal, NL Lapato, AS Bodhankar, S Offner, H Alkayed, NJ AF Zhu, W. Dotson, A. L. Libal, N. L. Lapato, A. S. Bodhankar, S. Offner, H. Alkayed, N. J. TI RECOMBINANT T-CELL RECEPTOR LIGAND RTL1000 LIMITS INFLAMMATION AND DECREASES INFARCT SIZE AFTER EXPERIMENTAL ISCHEMIC STROKE IN MIDDLE-AGED MICE SO NEUROSCIENCE LA English DT Article DE ischemic stroke; immunotherapy; recombinant T-cell receptor ligand; HLA-DR2 transgenic mice ID EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; RECOMMENDATIONS; LYMPHOCYTES AB We have previously demonstrated that recombinant T-cell receptor ligand 1000 (RTL1000) reduces infarct size and improves long-term functional recovery after experimental stroke in young transgenic mice expressing human leukocyte antigen DR2 (DR2-Tg). In this study, we determined the effect of RTL1000 on infarct size in 12-month-old middle-aged DR2-Tg mice, and investigated its mechanism of action. Twelve-month-old male DR2-Tg mice underwent 60 min of intraluminal reversible middle cerebral artery occlusion (MCAO). Vehicle or RTL1000 was injected 4, 24, 48 and 72 h after MCAO. Cortical, striatal and total hemispheric infarcts were measured 96 h after stroke. Spleen and brain tissues were collected 96 h after stroke for immunological analysis. Our data showed that RTL1000 significantly reduced infarct size 96 h after MCAO in middle-aged male DR2-Tg mice. RTL1000 decreased the number of activated monocytes/microglia cells (CD11b(+)CD45(hi)) and CD3(+) T cells in the ischemic hemisphere. RTL1000 also reduced the percentage of total T cells and inflammatory neutrophils in the spleen. These findings suggest that RTL1000 protects against ischemic stroke in middle-aged male mice by limiting post-ischemic inflammation. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved. C1 [Zhu, W.; Libal, N. L.; Offner, H.; Alkayed, N. J.] Oregon Hlth & Sci Univ, Dept Anesthesiol & Perioperat Med, Portland, OR 97239 USA. [Alkayed, N. J.] Oregon Hlth & Sci Univ, Knight Cardiovasc Inst, Portland, OR 97239 USA. [Dotson, A. L.; Lapato, A. S.; Bodhankar, S.; Offner, H.; Alkayed, N. J.] Oregon Hlth & Sci Univ, Dept Neurol, Portland, OR 97239 USA. [Dotson, A. L.; Lapato, A. S.; Bodhankar, S.; Offner, H.] Portland VA Med Ctr, Portland, OR 97239 USA. RP Alkayed, NJ (reprint author), Oregon Hlth & Sci Univ, Dept Anesthesiol & Perioperat Med, Portland, OR 97239 USA. EM alkayedn@ohsu.edu OI Lapato, Andrew/0000-0002-4931-7370 FU NIH [NS076013 (STTR)]; Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Biomedical Laboratory Research and Development FX This work was supported by NIH Grants #NS076013 (STTR) and by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Biomedical Laboratory Research and Development. NR 30 TC 2 Z9 2 U1 1 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0306-4522 EI 1873-7544 J9 NEUROSCIENCE JI Neuroscience PD MAR 12 PY 2015 VL 288 BP 112 EP 119 DI 10.1016/j.neuroscience.2014.12.037 PG 8 WC Neurosciences SC Neurosciences & Neurology GA CA2TD UT WOS:000348759600011 PM 25556831 ER PT J AU Barrett, TW Shanmugam, NR Selvam, AP Kazmierczak, SC Prasad, S AF Barrett, Thomas W. Shanmugam, Nandhinee Radha Selvam, Anjan Panneer Kazmierczak, Steven C. Prasad, Shalini TI Novel Nanomonitor ultra-sensitive detection of troponin T SO CLINICA CHIMICA ACTA LA English DT Article DE Point-of-care; Nanotechnology; Troponin T; Functional sensitivity ID CARDIAC TROPONIN; MYOCARDIAL-INFARCTION; ASSAYS; DIAGNOSTICS; POPULATION; PREDICTION; DISEASE AB Background: Troponin is the preferred biomarker for diagnosing myocardial infarction. Point of care devices have not matched the sensitivity of laboratory-based methods for measuring troponin. The Nanomonitor is a novel point-of-care device that uses the change in electrical impedance that occurs when a biomarker binds to its antibody, which is then correlated to the concentration of the target biomarker. Methods: Performance characteristics of the Nanomonitor were evaluated and compared to a standard laboratory-based method. Results: The limit of detection of the Nanomonior for troponin T was 0.0088 ng/l. Total imprecission was 238% and 0.85% at troponin T concentrations of 73 ng/l and 1800 ng/l. The functional sensitivity (10% coeffecient of variation) was 0329 ng/l. The linear regression had a slope of 0.996 (95% confidence interval, 0.991, 1.002), r = 1.00, and an intercept of 15.88 ng/l (95% confidence interval, -68.39 ng/l, 100.15 ng/l). The mean difference between the assays was -7.54 ng/l, determined by Bland-Altman analysis. Conclusion: The Nanomonitor preliminary results have favorable performance characteristics for detecting troponin Tin patient blood, provide results in 15 min, and are portable. More research is needed. (C) 2015 Elsevier B.V. All rights reserved. C1 [Barrett, Thomas W.] Portland VA Med Ctr, Portland, OR USA. [Shanmugam, Nandhinee Radha; Selvam, Anjan Panneer; Prasad, Shalini] Oregon Hlth & Sci Univ, Div Hosp Med, Portland, OR 97201 USA. [Kazmierczak, Steven C.] Univ Texas Dallas, Dept Bioengn, Richardson, TX 75080 USA. Oregon Hlth & Sci Univ, Dept Pathol, Portland, OR 97201 USA. RP Prasad, S (reprint author), Univ Texas Dallas, Dept Bioengn, 800 W Campbell Rd,EC 39, Richardson, TX 75080 USA. EM Shalini.Prasad@utdallas.edu RI Radha Shanmugam, Nandhinee/D-1896-2017 OI Radha Shanmugam, Nandhinee/0000-0002-8572-7801 FU National Center for Research Resources (NCRR) [UL1 RR024140] FX This work was presented, in part, in poster form at the Materials Research Society Conference, April 24, 2014, San Francisco, California, "Rapid and Sensitive Detection of Nano-fluidically Trapped Protein Biomarkers". Oregon Nanoscience and Microtechnologies Institute, and Oregon Clinical and Translational Research Institute (OCTRI), grant number UL1 RR024140 from the National Center for Research Resources (NCRR) and the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH), and the Cecil and Ida Green Endowment in Systems Biology at University of Texas at Dallas. NR 25 TC 5 Z9 5 U1 2 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-8981 EI 1873-3492 J9 CLIN CHIM ACTA JI Clin. Chim. Acta PD MAR 10 PY 2015 VL 442 BP 96 EP 101 DI 10.1016/j.cca.2015.01.013 PG 6 WC Medical Laboratory Technology SC Medical Laboratory Technology GA CE7TY UT WOS:000352045900019 PM 25619774 ER PT J AU Nowacki, M Nazarewski, L Pokrywczynska, M Kloskowski, T Tyloch, D Pietkun, K Jundzill, A Rasmus, M Warda, K Gagat, M Grzanka, A Bodnar, M Marszalek, A Krawczyk, M Habib, SL Drewa, T AF Nowacki, Maciej Nazarewski, Lukasz Pokrywczynska, Marta Kloskowski, Tomasz Tyloch, Dominik Pietkun, Katarzyna Jundzill, Arkadiusz Rasmus, Marta Warda, Karolina Gagat, Maciej Grzanka, Alina Bodnar, Magdalena Marszalek, Andrzej Krawczyk, Marek Habib, Samy L. Drewa, Tomasz TI Long-Term Influence of Bone Marrow-Derived Mesenchymal Stem Cells on Liver Ischemia-Reperfusion Injury in a Rat Model SO ANNALS OF TRANSPLANTATION LA English DT Article DE Mesenchymal Stromal Cells; Reperfusion Injury; Tissue Engineering ID HEPATIC ISCHEMIA/REPERFUSION INJURY; WARM ISCHEMIA; ANIMAL-MODELS; MURINE MODEL; TRANSPLANTATION; APOPTOSIS; PROTECTS; THERAPY; SURGERY; INNATE AB Background: The aim of this study was to evaluate the long-term usefulness of intraportal injection of the bone marrow-derived mesenchymal stem cells (BM-MSCs) in limitation of experimentally induced ischemia-reperfusion injury (IRI) in a rat model. Material/Methods: Twenty Wistar rats were divided into 3 groups: donor group (n=5), study group (n=10), and control group (n=5). IRI was performed using a modified hanging-weight system after left portal triad occlusion in study group animals. Isolated autologous BM-MSCs were labeled with fluorochrome PKH-26 then intraportally injected into the rats in the study group. Control group animals were intraportally injected with 1 ml of PBS. Follow-up was 3 months, after which animals were sacrificed for histopathological examination. Migration of BM-MSCs into different organs was examined. Results: H&E staining of liver tissue sections from "time zero" biopsies did not show many irregularities in structural or histological construction compared to liver sections from the control group. However, a small amount of centrilobular hepatocyte necrosis and coagulative necrosis with neutrophil infiltration areas was observed in liver sections of the study group. The migration assay of BM-MSCs labeled with PKH-26 showed the highest positive BM-MSCs staining (6%) in the spleen, while few positively stained cells were found (2%) in liver sections. No BM-MSCs were detected in brain, kidney, or lung tissues. Conclusions: These results suggest that intraportal bone marrow-derived mesenchymal stem cell injection is safe and cells do not migrate chaotically to other organs after targeted implementation. C1 [Nowacki, Maciej; Pokrywczynska, Marta; Kloskowski, Tomasz; Tyloch, Dominik; Pietkun, Katarzyna; Jundzill, Arkadiusz; Rasmus, Marta; Warda, Karolina; Drewa, Tomasz] Nicolaus Copernicus Univ Torun, Coll Med Bydgoszcz, Dept Tissue Engn, Chair Regenerat Med, Bydgoszcz, Poland. [Nazarewski, Lukasz; Krawczyk, Marek] Med Univ Warsaw, Dept Gen Transplant & Liver Surg, Warsaw, Poland. [Gagat, Maciej; Grzanka, Alina] Nicolaus Copernicus Univ Torun, Coll Med Bydgoszcz, Dept Histol & Embryol, Bydgoszcz, Poland. [Bodnar, Magdalena; Marszalek, Andrzej] Nicolaus Copernicus Univ Torun, Coll Med Bydgoszcz, Dept Clin Pathomorphol, Bydgoszcz, Poland. [Marszalek, Andrzej] Poznan Univ Med Sci, Dept Oncol Pathol, Poznan, Poland. [Marszalek, Andrzej] Greater Poland Oncol Ctr, Poznan, Poland. [Habib, Samy L.] South Texas Vet Hlth Care Syst, San Antonio, TX USA. [Habib, Samy L.] Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol, San Antonio, TX 78229 USA. [Drewa, Tomasz] Nicolaus Copernicus Hosp, Dept Gen & Oncol Urol, Torun, Poland. RP Kloskowski, T (reprint author), Nicolaus Copernicus Univ Torun, Coll Med Bydgoszcz, Dept Tissue Engn, Chair Regenerat Med, Bydgoszcz, Poland. EM tomaszkloskowski@op.pl RI Kloskowski, Tomasz/D-4353-2014; Bodnar, Magdalena/D-6131-2014; Gagat, Maciej/D-5356-2014; Grzanka, Alina/D-9941-2014; Pietkun , Katarzyna/Q-6718-2016 OI Kloskowski, Tomasz/0000-0001-5599-9315; Bodnar, Magdalena/0000-0003-3748-1058; Gagat, Maciej/0000-0002-5445-8821; FU Nicolaus Copernicus University [112, 266] FX This work was supported by research task within framework of the statutory activities no. 112 and 266 from Nicolaus Copernicus University NR 47 TC 3 Z9 3 U1 1 U2 5 PU INT SCIENTIFIC LITERATURE, INC PI SMITHTOWN PA 361 FOREST LANE, SMITHTOWN, NY 11787 USA SN 1425-9524 J9 ANN TRANSPL JI Ann. Transpl. PD MAR 10 PY 2015 VL 20 BP 132 EP 140 DI 10.12659/AOT.892364 PG 9 WC Surgery; Transplantation SC Surgery; Transplantation GA CE0DV UT WOS:000351475600001 PM 25754665 ER PT J AU Medeiros, K O'Connor, M Baicu, CF Fitzgibbons, T Shaw, P Tighe, DA Zile, MR Aurigemma, GP AF Medeiros, Keith O'Connor, Mark Baicu, Catalin F. Fitzgibbons, Timothy Shaw, Peter Tighe, Dennis A. Zile, Michael R. Aurigemma, Gerard P. TI Response to Letters Regarding Article, "Systolic and Diastolic Mechanics in Stress Cardiomyopathy" SO CIRCULATION LA English DT Letter C1 [Medeiros, Keith; O'Connor, Mark; Fitzgibbons, Timothy; Tighe, Dennis A.; Aurigemma, Gerard P.] Univ Massachusetts, Sch Med, Dept Med, Div Cardiovasc Med, Worcester, MA 01655 USA. [Baicu, Catalin F.; Zile, Michael R.] Med Univ S Carolina, Dept Med, Div Cardiol, Charleston, SC 29425 USA. [Baicu, Catalin F.; Zile, Michael R.] Vet Affairs Med Ctr, Ralph H Johnson Dept, Charleston, SC 29403 USA. [Shaw, Peter] Univ Virginia, Sch Med, Dept Med, Div Cardiovasc Med, Charlottesville, VA 22908 USA. RP Medeiros, K (reprint author), Univ Massachusetts, Sch Med, Dept Med, Div Cardiovasc Med, Worcester, MA 01655 USA. OI Fitzgibbons, Timothy/0000-0003-0229-034X NR 3 TC 1 Z9 1 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0009-7322 EI 1524-4539 J9 CIRCULATION JI Circulation PD MAR 10 PY 2015 VL 131 IS 10 BP E372 EP E372 DI 10.1161/CIRCULATIONAHA.114.012819 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA CD0NR UT WOS:000350771700005 PM 25753351 ER PT J AU Lin, CW Chang, LC Tseng, GC Kirkwood, CM Sibille, EL Sweet, RA AF Lin, Chien-Wei Chang, Lun-Ching Tseng, George C. Kirkwood, Caitlin M. Sibille, Etienne L. Sweet, Robert A. TI VSNL1 co-expression networks in aging include calcium signaling, synaptic plasticity, and Alzheimer's disease pathways SO FRONTIERS IN PSYCHIATRY LA English DT Article DE visinin-like 1; visinin-like protein 1; Alzheimer disease; co-expression networks; calcium signaling; synaptic plasticity ID VISININ-LIKE PROTEINS; AMYLOID-BETA-PEPTIDE; COGNITIVE DECLINE; GENE-EXPRESSION; HUMAN BRAIN; SENSOR; CORTEX; TRANSCRIPTOME; DISORDERS; DISCOVERY AB The visinin-like 1 (VSNL1) gene encodes visinin-like protein 1, a peripheral biomarker for Alzheimer disease (AD). Little is known, however, about normal VSNL1 expression in brain and the biologic networks in which it participates. Frontal cortex gray matter obtained from 209 subjects without neurodegenerative or psychiatric illness, ranging in age from 16 to 91, was processed on Affymetrix GeneChip 1.1 ST and Human SNP Array 6.0. VSNL1 expression was unaffected by age and sex, and not significantly associated with SNPs in cis or trans. VSNL1 was significantly co-expressed with genes in pathways for calcium signaling, AD, long-term potentiation, long-term depression, and trafficking of AMPA receptors. The association with AD was driven, in part, by correlation with amyloid precursor protein (APP) expression. These findings provide an unbiased link between VSNL1 and molecular mechanisms of AD, including pathways implicated in synaptic pathology in AD. Whether APP may drive increased VSNL1 expression, VSNL1 drives increased APP expression, or both are downstream of common pathogenic regulators will need to be evaluated in model systems. C1 [Lin, Chien-Wei; Chang, Lun-Ching; Tseng, George C.] Univ Pittsburgh, Dept Biostat, Pittsburgh, PA 15213 USA. [Kirkwood, Caitlin M.; Sibille, Etienne L.; Sweet, Robert A.] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15213 USA. [Sibille, Etienne L.] Univ Toronto, Dept Psychiat, Campbell Family Mental Hlth Res Inst, CAMH, Toronto, ON, Canada. [Sibille, Etienne L.] Univ Toronto, Dept Pharmacol &Toxicol, Campbell Family Mental Hlth Res Inst, CAMH, Toronto, ON, Canada. [Sweet, Robert A.] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15260 USA. [Sweet, Robert A.] VA Pittsburgh Healthcare Syst, VISN Mental Illness Res Educ & Clin Ctr MIRECC 4, Pittsburgh, PA USA. RP Sweet, RA (reprint author), Univ Pittsburgh, Dept Psychiat, Biomed Sci Tower,Room W-1645,3811 OHara St, Pittsburgh, PA 15213 USA. EM sweetra@upmc.edu FU BLRD VA [I01 BX000452]; NIA NIH HHS [F31 AG044070, P50 AG005133, R01 AG027224]; NIMH NIH HHS [R01 MH093723, K02 MH084060, R01 MH071533, R21 MH094862] NR 50 TC 3 Z9 4 U1 2 U2 4 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1664-0640 J9 FRONT PSYCHIATRY JI Front. Psychiatry PD MAR 9 PY 2015 VL 6 AR 30 DI 10.3389/fpsyt.2015.00030 PG 9 WC Psychiatry SC Psychiatry GA CV4BA UT WOS:000364209200001 PM 25806004 ER PT J AU Claycomb, MA Wang, L Sharp, C Ractliffe, KC Elhai, JD AF Claycomb, Meredith A. Wang, Li Sharp, Carla Ractliffe, Kendra C. Elhai, Jon D. TI Assessing Relations between PTSD's Dysphoria and Reexperiencing Factors and Dimensions of Rumination SO PLOS ONE LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; CONFIRMATORY FACTOR-ANALYSIS; DEPRESSED MOOD; SYMPTOMS; MEMORIES; DURATION; EPISODES; MODEL AB The purpose of the present study was to investigate the relations between posttraumatic stress disorder's (PTSD) dysphoria and reexperiencing factors and underlying dimensions of rumination. 304 trauma-exposed primary care patients were administered the Stressful Life Events Screening Questionnaire, PTSD Symptom Scale based on their worst traumatic event, and Ruminative Thought Style Questionnaire (RTSQ). Confirmatory factor analyses (CFAs) were conducted to determine the dysphoria and reexperiencing factors' relationships with the four factors of rumination. Results revealed that both the dysphoria and reexperiencing factors related more to problem-focused thinking and anticipatory thoughts than counterfactual thinking. Additionally, the reexperiencing factor related more to anticipatory thinking than repetitive thinking. Clinical and theoretical implications are discussed. C1 [Claycomb, Meredith A.; Elhai, Jon D.] Univ Toledo, Dept Psychol, Toledo, OH 43606 USA. [Wang, Li] Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China. [Sharp, Carla] Univ Houston, Dept Psychol, Baylor Coll Med, Menninger Clin, Houston, TX USA. [Ractliffe, Kendra C.] San Francisco VA Med Ctr, San Francisco, CA USA. [Elhai, Jon D.] Univ Toledo, Dept Psychiat, Toledo, OH 43606 USA. RP Elhai, JD (reprint author), Univ Toledo, Dept Psychol, Toledo, OH 43606 USA. EM contact@jon-elhai.com OI wang, li/0000-0002-1459-3412 NR 35 TC 5 Z9 5 U1 2 U2 11 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 4 PY 2015 VL 10 IS 3 AR e0118435 DI 10.1371/journal.pone.0118435 PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CC9JM UT WOS:000350685900034 PM 25738868 ER PT J AU Blount, JW Redan, BW Ferruzzi, MG Reuhs, BL Cooper, BR Harwood, JS Shulaev, V Pasinetti, G Dixon, RA AF Blount, Jack W. Redan, Benjamin W. Ferruzzi, Mario G. Reuhs, Bradley L. Cooper, Bruce R. Harwood, John S. Shulaev, Vladimir Pasinetti, Giulio Dixon, Richard A. TI Synthesis and Quantitative Analysis of Plasma-Targeted Metabolites of Catechin and Epicatechin SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY LA English DT Article DE catechin; glucuronosylation; O-methylation; phase II metabolites; semisynthesis; structure determination; two-site validation ID (-)-EPICATECHIN METABOLITES; GASTROINTESTINAL-TRACT; ALZHEIMERS-DISEASE; ORAL INGESTION; RAT PLASMA; IN-VIVO; MATRIX; BIOAVAILABILITY; PROCYANIDINS; FLAVAN-3-OLS AB Grape seed polyphenolic extract (GSPE) rich in the flavan-3-ols (+)-catechin and (-)-epicatechin beneficially modulates Alzheimer's Disease phenotypes in animal models. The parent molecules in the extract are converted to a series of methylated and glucuronidated derivatives. To fully characterize these metabolites and establish a robust quantitative assay of their levels in biological fluids, we have implemented a partial synthetic approach utilizing chemical methylation followed by enzymatic glucuronidation. Liquid chromatography/time-of-flight mass spectrometry (LC-TOF-MS) and nuclear magnetic resonance (NMR) spectroscopy were used to assign unequivocal structures to the compounds. An analytical method using solid-phase extraction and LC-MS/MS in selective reaction monitoring mode (SRM) was validated for their quantitation in plasma. These studies provide a basis for improvements in future work on the bioavailability, metabolism, and mechanism of action of metabolites derived from dietary flavan-3-ols in a range of interventions. C1 [Blount, Jack W.; Shulaev, Vladimir; Dixon, Richard A.] Univ N Texas, Dept Biol Sci, Denton, TX 76203 USA. [Redan, Benjamin W.; Ferruzzi, Mario G.; Reuhs, Bradley L.] Purdue Univ, Dept Nutr Sci, W Lafayette, IN 47907 USA. [Ferruzzi, Mario G.] Purdue Univ, Dept Food Sci, W Lafayette, IN 47907 USA. [Pasinetti, Giulio] Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA. [Pasinetti, Giulio] James J Peters Vet Affairs Med Ctr, Bronx, NY USA. [Cooper, Bruce R.] Purdue Univ, Bindley Biosci Ctr Metabolite Profiling Facil, W Lafayette, IN 47907 USA. [Harwood, John S.] Purdue Univ, Purdue Interdept NMR Facil, W Lafayette, IN 47907 USA. [Harwood, John S.] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA. RP Dixon, RA (reprint author), Univ N Texas, Dept Biol Sci, 1155 Union Circle 305220, Denton, TX 76203 USA. EM Richard.Dixon@unt.edu FU National Institutes of Health [5 PO1 AT004511-05]; University of North Texas; Purdue University; Career Scientist Award in the Research and Development unit; National Science Foundation [DGE-1333468] FX This work was supported by National Institutes of Health grant 5 PO1 AT004511-05 Administrative Supplement to G.P. and by the University of North Texas and Purdue University. This material is also the result of work supported in part with resources and the use of facilities at the James J. Peters Veterans Affairs Medical Center, Bronx, NY. In addition, GMP holds a Career Scientist Award in the Research and Development unit and is the Director of the Basic and Biomedical Research and Training Program, GRECC, James J. Peters Veterans Affairs Medical Center. We acknowledge that the contents of this manuscript do not represent the views of the U.S. Department of Veterans Affairs or the United States Government. B.W.R. is supported by National Science Foundation grant DGE-1333468. NR 27 TC 4 Z9 4 U1 7 U2 50 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0021-8561 EI 1520-5118 J9 J AGR FOOD CHEM JI J. Agric. Food Chem. PD MAR 4 PY 2015 VL 63 IS 8 BP 2233 EP 2240 PG 8 WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science & Technology SC Agriculture; Chemistry; Food Science & Technology GA CC8JR UT WOS:000350615000014 PM 25671729 ER PT J AU Akamatsu, Y Nishijima, Y Lee, CC Yang, SY Shi, L An, L Wang, RK Tominaga, TJ Liu, JL AF Akamatsu, Yosuke Nishijima, Yasuo Lee, Chih Cheng Yang, Shih Yen Shi, Lei An, Lin Wang, Ruikang K. Tominaga, Teiji Liu, Jialing TI Impaired Leptomeningeal Collateral Flow Contributes to the Poor Outcome following Experimental Stroke in the Type 2 Diabetic Mice SO JOURNAL OF NEUROSCIENCE LA English DT Article DE anastomosis; arteriogenesis; Doppler OCT; MCAO; metabolic syndrome; vascular remodeling ID ACUTE ISCHEMIC-STROKE; FOCAL CEREBRAL-ISCHEMIA; PLASMINOGEN-ACTIVATOR INHIBITOR-1; MARKED NEUROPROTECTIVE EFFICACY; ALBUMIN THERAPY; BLOOD-FLOW; IN-VIVO; MICROVASCULAR RESPONSES; SERUM-ALBUMIN; HYPERGLYCEMIA AB Collateral status is an independent predictor of stroke outcome. However, the spatiotemporal manner in which collateral flow maintains cerebral perfusion during cerebral ischemia is poorly understood. Diabetes exacerbates ischemic brain damage, although the impact of diabetes on collateral dynamics remains to be established. Using Doppler optical coherent tomography, a robust recruitment of leptomeningeal collateral flow was detected immediately after middle cerebral artery ( MCA) occlusion in C57BL/6 mice, and it continued to grow over the course of 1 week. In contrast, an impairment of collateral recruitment was evident in the Type 2 diabetic db/db mice, which coincided with a worse stroke outcome compared with their normoglycemic counterpart db/+, despite their equally well-collateralized leptomeningeal anastomoses. Similar to the wild-type mice, both db/+ and db/db mice underwent collateral growth 7 d after MCA stroke, although db/db mice still exhibited significantly reduced retrograde flow into the MCA territory chronically. Acutely induced hyperglycemia in the db/+ mice did not impair collateral flow after stroke, suggesting that the state of hyperglycemia alone was not sufficient to impact collateral flow. Human albumin was efficacious in improving collateral flow and outcome after stroke in the db/db mice, enabling perfusion to proximal MCA territory that was usually not reached by retrograde flow from anterior cerebral artery without treatment. Our results suggest that the impaired collateral status contributes to the exacerbated ischemic injury in mice with Type 2 diabetes, and modulation of collateral flow has beneficial effects on stroke outcome among these subjects. C1 [Akamatsu, Yosuke; Nishijima, Yasuo; Lee, Chih Cheng; Yang, Shih Yen; Liu, Jialing] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94121 USA. [Akamatsu, Yosuke; Nishijima, Yasuo; Lee, Chih Cheng; Yang, Shih Yen; Liu, Jialing] San Francisco VA Med Ctr, San Francisco, CA 94121 USA. [Akamatsu, Yosuke; Nishijima, Yasuo; Tominaga, Teiji] Tohoku Univ, Grad Sch Med, Dept Neurosurg, Sendai, Miyagi 9808574, Japan. [Shi, Lei; An, Lin; Wang, Ruikang K.] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA. [Shi, Lei; An, Lin; Wang, Ruikang K.] Univ Washington, Dept Ophthalmol, Seattle, WA 98195 USA. RP Liu, JL (reprint author), Univ Calif San Francisco, Dept Neurol Surg 112C, 1700 Owens St, San Francisco, CA 94158 USA. EM jialing.liu@ucsf.edu RI Liu, Jialing/A-8627-2012 OI Liu, Jialing/0000-0003-4420-4382 FU National Institutes of Health [R01 NS071050]; Veterans Administration Merit Award [I01RX000655]; American Heart Hospital Association [EIA 0940065N]; NIH [R01HL093140] FX This work was supported by National Institutes of Health Grant R01 NS071050 to J.L., Veterans Administration Merit Award I01RX000655 to J. L., American Heart Hospital Association EIA 0940065N to J.L., and NIH R01HL093140 to R.K.W. We thank Dr. Philip Weinstein (University of California at San Francisco) for helpful discussion and Ilona Garner (University of California at San Francisco) for editorial assistance. NR 55 TC 13 Z9 13 U1 1 U2 5 PU SOC NEUROSCIENCE PI WASHINGTON PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA SN 0270-6474 J9 J NEUROSCI JI J. Neurosci. PD MAR 4 PY 2015 VL 35 IS 9 BP 3851 EP 3864 DI 10.1523/JNEUROSCI.3838-14.2015 PG 14 WC Neurosciences SC Neurosciences & Neurology GA CD0DP UT WOS:000350740900013 PM 25740515 ER PT J AU Ruben, MA Hall, JA Mast, MS AF Ruben, Mollie A. Hall, Judith A. Mast, Marianne Schmid TI Smiling in a Job Interview: When Less Is More SO JOURNAL OF SOCIAL PSYCHOLOGY LA English DT Article DE smiling; interview context; nonverbal behavior; hiring decisions; impression management ID NONVERBAL BEHAVIOR; EMPLOYMENT INTERVIEWS; SELECTION INTERVIEW; METAANALYSIS; FEMALE; COMMUNICATION; JUDGMENTS; PERFORMANCE; APPLICANTS; TACTICS AB Two studies examined the effect of applicants' smiling on hireability. In a pre-test study, participants were asked to rate the expected behavior for four types of applicants. Newspaper reporter applicants were expected to be more serious than applicants for other jobs. In Study 1, participants were randomly assigned to be an applicant or interviewer for a newspaper reporting job. Smiling was negatively related to hiring, and smiling mediated the relation between applicants' motivation to make a good impression and hiring. Hiring was maximized when applicants smiled less in the middle of the interview relative to the start and end. In Study 2, participants watched Study 1 clips and were randomly assigned to believe the applicants were applying to one of four jobs. Participants rated more suitability when applicants smiled less, especially for jobs associated with a serious demeanor. This research shows that job type is an important moderator of the impact of smiling on hiring. C1 [Ruben, Mollie A.] US Dept Vet Affairs, Ctr Healthcare Org & Implementat Res, Boston, MA 02130 USA. [Hall, Judith A.] Northeastern Univ, Dept Psychol, Boston, MA USA. [Mast, Marianne Schmid] Univ Lausanne, Dept Org Behav, CH-1015 Lausanne, Switzerland. RP Ruben, MA (reprint author), US Dept Vet Affairs, Ctr Healthcare Org & Implementat Res, 150 S Huntington Ave,Bldg 9, Boston, MA 02130 USA. EM mollie.ruben@va.gov OI Ruben, Mollie/0000-0001-8918-8932 NR 33 TC 2 Z9 2 U1 4 U2 30 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0022-4545 EI 1940-1183 J9 J SOC PSYCHOL JI J. Soc. Psychol. PD MAR 4 PY 2015 VL 155 IS 2 BP 107 EP 126 DI 10.1080/00224545.2014.972312 PG 20 WC Psychology, Social SC Psychology GA CB0PG UT WOS:000349328100003 PM 25309976 ER PT J AU Barocas, JA Erlandson, KM Belzer, BK Hess, T Sosman, J AF Barocas, Joshua A. Erlandson, Kristine M. Belzer, Blythe K. Hess, Timothy Sosman, James TI Advance directives among people living with HIV: room for improvement SO AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV LA English DT Article DE patient care; outpatient clinic; HIV/AIDS; advance care planning; advance directives ID OF-LIFE CARE; CANCER-PATIENTS; HEART-FAILURE; ATTITUDES; COMPLETION; BARRIERS; DISEASE; COMMUNICATION; ADULTS; INTERVENTION AB While HIV has become a largely chronic disease, age-associated comorbidities are prevalent in people living with HIV (PLWH). Therefore, PLWH are appropriate for advance care planning (ACP) and advance directives (ADs) completion. We sought to characterize AD completion among outpatient PLWH. We conducted a retrospective chart review of PLWH who receive their routine care at the University of Wisconsin HIV clinic. Data were extracted from the electronic health record. Variables were entered into a stepwise multivariate logistic regression model to assess which factors were independently associated with AD completion. Five hundred and eighty eight charts were reviewed. Eighty-one percent of subjects were male and 72% were white; mean age was 46.8 years. ADs were completed by 134 subjects and 6.7% of those were completed at the HIV clinic. In the final multivariate model, those who had completed an AD were more likely to be older than age 45; ever been diagnosed with AIDS; have cardiovascular disease, neurologic disorder, chronic kidney disease, or malignancy. In this study, a small percentage of patients had documented ADs, with only a small proportion completed in the HIV clinic. The HIV clinic is an underutilized resource to offer ACP. Interventions are needed to provide the necessary ACP resources for PLWH. C1 [Barocas, Joshua A.; Belzer, Blythe K.] Univ Wisconsin, Dept Med, Sch Med & Publ Hlth, Madison, WI 53718 USA. [Barocas, Joshua A.] William S Middleton Mem Vet Adm Med Ctr, Madison, WI USA. [Erlandson, Kristine M.] Univ Colorado, Dept Med, Div Infect Dis, Aurora, CO USA. [Hess, Timothy; Sosman, James] Univ Wisconsin, Sch Med & Publ Hlth, Div Infect Dis, Madison, WI USA. RP Barocas, JA (reprint author), Univ Wisconsin, Dept Med, Sch Med & Publ Hlth, Madison, WI 53718 USA. EM jbarocas@medicine.wisc.edu NR 48 TC 1 Z9 1 U1 2 U2 4 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0954-0121 EI 1360-0451 J9 AIDS CARE JI Aids Care-Psychol. Socio-Med. Asp. Aids-Hiv PD MAR 4 PY 2015 VL 27 IS 3 BP 370 EP 377 DI 10.1080/09540121.2014.963019 PG 8 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychology, Multidisciplinary; Respiratory System; Social Sciences, Biomedical SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychology; Respiratory System; Biomedical Social Sciences GA CA1HI UT WOS:000348663000016 PM 25307722 ER PT J AU Lovejoy, J Riffe, D Lovejoy, TI AF Lovejoy, Jennette Riffe, Daniel Lovejoy, Travis I. TI An Examination of Direct and Indirect Effects of Exposure and Attention to Health Media on Intentions to Avoid Unprotected Sun Exposure SO HEALTH COMMUNICATION LA English DT Article ID COGNITIVE VARIABLES RELEVANT; PARENT-BASED INTERVENTION; SKIN-CANCER PREVENTION; UNITED-STATES; PLANNED BEHAVIOR; SUNSCREEN USE; NEWS COVERAGE; PROTECTION; ATTITUDES; ADULTS AB Skin cancer is the most commonly diagnosed cancer in the United States, accounting for more than 2 million diagnoses and more than 9,000 deaths annually. A regional online survey of students enrolled at institutions of higher education (N = 1,251) examined (a) associations between health media use and intentions to avoid unprotected sun exposure and (b) theoretically derived health behavior constructs that may mediate the relationship between media use and individuals' decisions to avoid unprotected sun exposure. Individuals with greater exposure and attention to health information in television, magazines, and newspapers had higher intentions to avoid unprotected sun exposure. Multiple mediation models indicated that health behavior constructs collectively mediated the relationship between television use and sun-protective behavioral intentions. Both cumulative and specific indirect mediating effects were observed for the relationship between magazine use and sun-protective behavioral intentions. However, the direction of effects was opposite to the hypothesized direction, due primarily to the association of magazine use with less favorable attitudes about sun protection and reduced behavioral control to avoid unprotected sun exposure. This study provides preliminary evidence for the interrelationships among media use, internal psychological states and cognitions, and health behavior decision making. Future studies should further explicate the mediating processes that account for the relationships between media and health behavior. C1 [Lovejoy, Jennette] Univ Portland, Dept Commun Studies, Portland, OR 97203 USA. [Riffe, Daniel] Univ N Carolina, Sch Journalism & Mass Commun, Chapel Hill, NC USA. [Lovejoy, Travis I.] Oregon Hlth & Sci Univ, Dept Psychiat, Portland Vet Affairs Med Ctr, Mental Hlth & Clin Neurosci Div, Portland, OR 97201 USA. RP Lovejoy, J (reprint author), Univ Portland, Dept Commun Studies, Buckley Ctr 233, 5000 N Willamette Blvd, Portland, OR 97203 USA. EM lovejoy@up.edu NR 59 TC 2 Z9 2 U1 5 U2 33 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1041-0236 EI 1532-7027 J9 HEALTH COMMUN JI Health Commun. PD MAR 4 PY 2015 VL 30 IS 3 BP 261 EP 270 DI 10.1080/10410236.2013.842526 PG 10 WC Communication; Health Policy & Services SC Communication; Health Care Sciences & Services GA AW9NZ UT WOS:000346585600006 PM 24597527 ER PT J AU Wang, GH Shi, YJ Jiang, XY Leak, RK Hu, XM Wu, Y Pu, HJ Li, WW Tang, B Wang, Y Gao, YQ Zheng, P Bennett, MVL Chen, J AF Wang, Guohua Shi, Yejie Jiang, Xiaoyan Leak, Rehana K. Hu, Xiaoming Wu, Yun Pu, Hongjian Li, Wei-Wei Tang, Bo Wang, Yun Gao, Yanqin Zheng, Ping Bennett, Michael V. L. Chen, Jun TI HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3 beta/PTEN/Akt axis SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE traumatic brain injury; oligodendrocyte; microglial polarization; myelination; inflammation ID TRAUMATIC BRAIN-INJURY; MICROGLIA; ACTIVATION; NEUROPROTECTION; DEGENERATION; INFLAMMATION; CHALLENGES; ISCHEMIA; DYNAMICS; DAMAGE AB Severe traumatic brain injury (TBI) elicits destruction of both gray and white matter, which is exacerbated by secondary proinflammatory responses. Although white matter injury (WMI) is strongly correlated with poor neurological status, the maintenance of white matter integrity is poorly understood, and no current therapies protect both gray and white matter. One candidate approach that may fulfill this role is inhibition of class I/II histone deacetylases (HDACs). Here we demonstrate that the HDAC inhibitor Scriptaid protects white matter up to 35 d after TBI, as shown by reductions in abnormally dephosphorylated neurofilament protein, increases in myelin basic protein, anatomic preservation of myelinated axons, and improved nerve conduction. Furthermore, Scriptaid shifted microglia/macrophage polarization toward the protective M2 phenotype and mitigated inflammation. In primary cocultures of microglia and oligodendrocytes, Scriptaid increased expression of microglial glycogen synthase kinase 3 beta (GSK3 beta), which phosphorylated and inactivated phosphatase and tensin homologue (PTEN), thereby enhancing phosphatidylinositide 3-kinases (PI3K)/Akt signaling and polarizing microglia toward M2. The increase in GSK3 beta in microglia and their phenotypic switch to M2 was associated with increased preservation of neighboring oligodendrocytes. These findings are consistent with recent findings that microglial phenotypic switching modulates white matter repair and axonal remyelination and highlight a previously unexplored role for HDAC activity in this process. Furthermore, the functions of GSK3 beta may be more subtle than previously thought, in that GSK3 beta can modulate microglial functions via the PTEN/PI3K/Akt signaling pathway and preserve white matter homeostasis. Thus, inhibition of HDACs in microglia is a potential future therapy in TBI and other neurological conditions with white matter destruction. C1 [Wang, Guohua; Jiang, Xiaoyan; Pu, Hongjian; Li, Wei-Wei; Tang, Bo; Wang, Yun; Gao, Yanqin; Zheng, Ping; Chen, Jun] Fudan Univ, State Key Lab Med Neurobiol, Shanghai 200032, Peoples R China. [Wang, Guohua; Jiang, Xiaoyan; Pu, Hongjian; Li, Wei-Wei; Tang, Bo; Wang, Yun; Gao, Yanqin; Zheng, Ping; Chen, Jun] Fudan Univ, Inst Brain Sci, Shanghai 200032, Peoples R China. [Wang, Guohua; Shi, Yejie; Hu, Xiaoming; Wu, Yun; Pu, Hongjian; Gao, Yanqin; Chen, Jun] Univ Pittsburgh, Ctr Cerebrovasc Dis Res, Pittsburgh, PA 15213 USA. [Shi, Yejie; Hu, Xiaoming; Wu, Yun; Chen, Jun] Vet Affairs Pittsburgh Hlth Care Syst, Geriatr Res Educ & Clin Ctr, Pittsburgh, PA 15261 USA. [Leak, Rehana K.] Duquesne Univ, Mylan Sch Pharm, Div Pharmaceut Sci, Pittsburgh, PA 15282 USA. [Bennett, Michael V. L.] Albert Einstein Coll Med, Dominick P Purpura Dept Neurosci, Bronx, NY 10461 USA. RP Bennett, MVL (reprint author), Albert Einstein Coll Med, Dominick P Purpura Dept Neurosci, Bronx, NY 10461 USA. EM michael.bennett@einstein.yu.edu; chenj2@upmc.edu RI ; Gao, Yanqin/I-6790-2016 OI Leak, Rehana/0000-0003-2817-7417; Gao, Yanqin/0000-0002-4915-9819 FU National Institutes of Health [NS36736, NS43802, NS45048, NS45287]; US Department of Veterans Affairs Research Career Scientist Award; Chinese Natural Science Foundation [81020108021, 81171149, 81371306, 81000497, 81471257, 81228008]; PhD Training Grant [20120071110042]; Ministry of Education of the People's Republic of China Talent Training Fellowship Grant [J1210041]; State Administration of Foreign Experts Affairs High-End Distinguished Professorship Grant [GDW20133100069]; Hillman Foundation Award FX This research was supported by National Institutes of Health Grants NS36736, NS43802, and NS45048 (to J.C.) and NS45287 (to M.V.L.B.); US Department of Veterans Affairs Research Career Scientist Award (to J.C.); Chinese Natural Science Foundation Grants 81020108021, 81171149, and 81371306 (to Y.G.), 81000497 and 81471257 (to G.W.), and 81228008 (to J.C. and P.Z.), and PhD Training Grant 20120071110042 (to J.C.); Ministry of Education of the People's Republic of China Talent Training Fellowship Grant J1210041 (to B.T.); and State Administration of Foreign Experts Affairs High-End Distinguished Professorship Grant GDW20133100069 (to M.V.L.B.). R.K.L. is supported by a Hillman Foundation Award. NR 33 TC 44 Z9 48 U1 8 U2 34 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD MAR 3 PY 2015 VL 112 IS 9 BP 2853 EP 2858 DI 10.1073/pnas.1501441112 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CC3DK UT WOS:000350224900065 PM 25691750 ER PT J AU Shen, Q Huang, SL Duong, TQ AF Shen, Qiang Huang, Shiliang Duong, Timothy Q. TI Ultra-high spatial resolution basal and evoked cerebral blood flow MRI of the rat brain SO BRAIN RESEARCH LA English DT Article DE High resolution imaging; Columnar resolution; Layer specificity; Arterial spin labeling ID FUNCTIONAL MRI; OXYGEN-CONSUMPTION; QUANTITATIVE PERFUSION; SOMATOSENSORY CORTEX; BOLD RESPONSES; STROKE MODEL; CMRO2 FMRI; SPIN-ECHO; CBF; DIFFUSION AB Cerebral blood flow (CBF) is tightly coupled to metabolism and neural activity under normal physiological conditions, and is often perturbed in disease states. The goals of this study were to implement a high-resolution (up to 50 x 38 mu m(2)) CBF MRI protocol of the rat brain, create a digital CBF atlas, report CBF values for 30+ brain structures based on the atlas, and explore applications of high-resolution CBF fMRI of forepaw stimulation. Excellent blood-flow contrasts were observed among different cortical and subcortical structures. CBF MRI showed column-like alternating bright and dark bands in the neocortices, reflecting the layout of descending arterioles and ascending venules, respectively. CBF MRI also showed lamina-like alternating bright and dark layers across the cortical thicknesses, consistent with the underlying vascular density. CBF profiles across the cortical thickness showed two peaks in layers IV and VI and a shallow trough in layer V. Whole-brain CBF was about 0.89 ml/g/min, with the highest CBF values found amongst the neocortical structures (1 ml/g/min, range: 0.89-1.16 ml/g/min) and the lowest CBF values in the corpus callosum (0.32 ml/g/min), yielding a gray:white matter CBF ratio of 3.1. CBF fMRI responses peaked across layers IV V, whereas the BOLD fMRI responses showed a peak in the superficial layers High-resolution basal CBF MRI, evoked CBF fMRI, and CBF brain atlas can be used to study neurological disorders (such as ischemic stroke). (C) 2014 Elsevier B.V. All rights reserved. C1 [Shen, Qiang; Huang, Shiliang; Duong, Timothy Q.] Univ Texas Hlth Sci Ctr San Antonio, Res Imaging Inst, San Antonio, TX 78229 USA. [Shen, Qiang; Duong, Timothy Q.] Univ Texas Hlth Sci Ctr San Antonio, Dept Ophthalmol, San Antonio, TX 78229 USA. [Duong, Timothy Q.] Univ Texas Hlth Sci Ctr San Antonio, Dept Radiol, San Antonio, TX 78229 USA. [Duong, Timothy Q.] Univ Texas Hlth Sci Ctr San Antonio, Dept Physiol, San Antonio, TX 78229 USA. [Duong, Timothy Q.] South Texas Vet Hlth Care Syst, San Antonio, TX USA. RP Duong, TQ (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Res Imaging Inst, 8403 Floyd Curl Dr, San Antonio, TX 78229 USA. EM duongt@uthscsa.edu RI Shen, Qiang/B-8784-2008 OI Shen, Qiang/0000-0002-4287-3403 FU NIH [R01NS45879]; NIH/CTSA Pilot Grant [UL1TR001120]; American Heart Association [EIA0940104N, BGIA9300047] FX This work was supported in part by NIH (R01NS45879), a NIH/CTSA Pilot Grant (via UL1TR001120), and American Heart Association (EIA0940104N, BGIA9300047). NR 50 TC 2 Z9 2 U1 1 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0006-8993 EI 1872-6240 J9 BRAIN RES JI Brain Res. PD MAR 2 PY 2015 VL 1599 BP 126 EP 136 DI 10.1016/j.brainres.2014.12.049 PG 11 WC Neurosciences SC Neurosciences & Neurology GA CD7CH UT WOS:000351247900012 PM 25557404 ER PT J AU Kales, HC Gitlin, LN Lyketsos, CG AF Kales, Helen C. Gitlin, Laura N. Lyketsos, Constantine G. TI Assessment and management of behavioral and psychological symptoms of dementia SO BMJ-BRITISH MEDICAL JOURNAL LA English DT Review ID ALZHEIMERS-DISEASE PATIENTS; ATYPICAL ANTIPSYCHOTIC MEDICATIONS; SEROTONIN REUPTAKE INHIBITORS; RANDOMIZED CONTROLLED-TRIAL; PLACEBO-CONTROLLED TRIALS; HOME-BASED INTERVENTION; TO-MODERATE DEMENTIA; NEUROPSYCHIATRIC-SYMPTOMS; DOUBLE-BLIND; NURSING-HOME AB Behavioral and psychological symptoms of dementia include agitation, depression, apathy, repetitive questioning, psychosis, aggression, sleep problems, wandering, and a variety of inappropriate behaviors. One or more of these symptoms will affect nearly all people with dementia over the course of their illness. These symptoms are among the most complex, stressful, and costly aspects of care, and they lead to a myriad of poor patient health outcomes, healthcare problems, and income loss for family care givers. The causes include neurobiologically related disease factors; unmet needs; care giver factors; environmental triggers; and interactions of individual, care giver, and environmental factors. The complexity of these symptoms means that there is no "one size fits all solution," and approaches tailored to the patient and the care giver are needed. Non-pharmacologic approaches should be used first line, although several exceptions are discussed. Non-pharmacologic approaches with the strongest evidence base involve family care giver interventions. Regarding pharmacologic treatments, antipsychotics have the strongest evidence base, although the risk to benefit ratio is a concern. An approach to integrating non-pharmacologic and pharmacologic treatments is described. Finally, the paradigm shift needed to fully institute tailored treatments for people and families dealing with these symptoms in the community is discussed. C1 [Kales, Helen C.] Univ Michigan, Dept Psychiat, Sect Geriatr Psychiat, Ann Arbor, MI 48109 USA. [Kales, Helen C.] US Dept Vet Affairs, Ctr Clin Management Res, Ann Arbor, MI USA. [Kales, Helen C.] VA Ann Arbor Healthcare Syst, Geriatr Res Educ & Clin Ctr, Ann Arbor, MI USA. [Gitlin, Laura N.] Johns Hopkins Univ, Sch Nursing, Dept Community Publ Hlth, Baltimore, MD USA. [Gitlin, Laura N.] Johns Hopkins Univ, Sch Med, Div Geriatr & Gerontol, Baltimore, MD USA. [Gitlin, Laura N.] Johns Hopkins Univ, Ctr Innovat Care Aging, Baltimore, MD USA. [Lyketsos, Constantine G.] Johns Hopkins Bayview, Dept Psychiat & Behav Sci, Baltimore, MD USA. [Lyketsos, Constantine G.] Johns Hopkins Univ, Baltimore, MD USA. RP Kales, HC (reprint author), Univ Michigan, Dept Psychiat, Sect Geriatr Psychiat, Ann Arbor, MI 48109 USA. EM kales@umich.edu FU Johns Hopkins Alzheimer's Disease Research Center [P50AG005146]; [R01NR014200] FX HCK and LNG were supported in part by R01NR014200. CGL was supported in part by the Johns Hopkins Alzheimer's Disease Research Center (P50AG005146). NR 172 TC 39 Z9 40 U1 11 U2 57 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1756-1833 J9 BMJ-BRIT MED J JI BMJ-British Medical Journal PD MAR 2 PY 2015 VL 350 AR h369 DI 10.1136/bmj.h369 PG 16 WC Medicine, General & Internal SC General & Internal Medicine GA CC4BV UT WOS:000350296600007 PM 25731881 ER PT J AU Felker, GM Butler, J Collins, SP Cotter, G Davison, BA Ezekowitz, JA Filippatos, G Levy, PD Metra, M Ponikowski, P Soergel, DG Teerlink, JR Violin, JD Voors, AA Pang, PS AF Felker, G. Michael Butler, Javed Collins, Sean P. Cotter, Gad Davison, Beth A. Ezekowitz, Justin A. Filippatos, Gerasimos Levy, Phillip D. Metra, Marco Ponikowski, Piotr Soergel, David G. Teerlink, John R. Violin, Jonathan D. Voors, Adriaan A. Pang, Peter S. TI Heart Failure Therapeutics on the Basis of a Biased Ligand of the Angiotensin-2 Type 1 Receptor Rationale and Design of the BLAST-AHF Study (Biased Ligand of the Angiotensin Receptor Study in Acute Heart Failure) SO JACC-HEART FAILURE LA English DT Article DE BLAST-AHF; NT-proBNP; TRV027 ID LEFT-VENTRICULAR DYSFUNCTION; ACUTE MYOCARDIAL-INFARCTION; MULTIPLE END-POINTS; CLINICAL-TRIALS; INTRAVENOUS ENALAPRILAT; CARDIAC MYOCYTES; BETA-ARRESTINS; I RECEPTOR; PHASE-II; ASSOCIATION AB The BLAST-AHF (Biased Ligand of the Angiotensin Receptor Study in Acute Heart Failure) study is designed to test the efficacy and safety of TRV027, a novel biased ligand of the angiotensin-2 type 1 receptor, in patients with acute heart failure (AHF). AHF remains a major public health problem, and no currently-available therapies have been shown to favorably affect outcomes. TRV027 is a novel biased ligand of the angiotensin-2 type 1 receptor that antagonizes angiotensin-stimulated G-protein activation while stimulating beta-arrestin. In animal models, these effects reduce afterload while increasing cardiac performance and maintaining stroke volume. In initial human studies, TRV027 appears to be hemodynamically active primarily in patients with activation of the renin-angiotensin-aldosterone system, a potentially attractive profile for an AHF therapeutic. BLAST-AHF is an international prospective, randomized, phase IIb, dose-ranging study that will randomize up to 500 AHF patients with systolic blood pressure >= 120 mm Hg and <= 200 mm Hg within 24 h of initial presentation to 1 of 3 doses of intravenous TRV027 (1, 5, or 25 mg/h) or matching placebo (1: 1: 1: 1) for at least 48 h and up to 96 h. The primary endpoint is a composite of 5 clinical endpoints (dyspnea, worsening heart failure, length of hospital stay, 30-day rehospitalization, and 30-day mortality) combined using an average z-score. Secondary endpoints will include the assessment of dyspnea and change in amino-terminal pro-B-type natriuretic peptide. The BLAST-AHF study will assess the efficacy and safety of a novel biased ligand of the angiotensin-2 type 1 receptor in AHF. (C) 2015 by the American College of Cardiology Foundation. C1 [Felker, G. Michael] Duke Univ, Sch Med, Div Cardiol, Durham, NC USA. [Butler, Javed] SUNY Stony Brook, Div Cardiol, Stony Brook, NY 11794 USA. [Collins, Sean P.] Vanderbilt Univ, Dept Emergency Med, Nashville, TN 37235 USA. [Cotter, Gad; Davison, Beth A.] Momentum Res Inc, Durham, NC USA. [Ezekowitz, Justin A.] Univ Alberta, Canadian VIGOUR Ctr, Edmonton, AB, Canada. [Filippatos, Gerasimos] Athens Univ Hosp Attikon, Dept Cardiol, Athens, Greece. [Levy, Phillip D.] Wayne State Sch Med, Dept Emergency Med, Detroit, MI USA. [Levy, Phillip D.] Wayne State Sch Med, Cardiovasc Res Inst, Detroit, MI USA. [Metra, Marco] Univ Brescia, Dept Med & Surg Specialties, Cardiol, Radiol Sci & Publ Hlth, Brescia, Italy. [Ponikowski, Piotr] Med Univ, Clin Mil Hosp, Dept Cardiol, Wroclaw, Poland. [Soergel, David G.; Violin, Jonathan D.] Trevena Inc, King Of Prussia, PA USA. [Teerlink, John R.] San Francisco VA Med Ctr, Cardiol Sect, San Francisco, CA USA. [Teerlink, John R.] Univ Calif San Francisco, Sch Med, San Francisco, CA USA. [Voors, Adriaan A.] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands. [Pang, Peter S.] Indiana Univ Sch Med, Dept Emergency Med, Indianapolis, IN 46202 USA. RP Felker, GM (reprint author), Duke Clin Res Inst, 2400 Pratt St,Room 0311 Terrace Level, Durham, NC 27710 USA. EM Michael.felker@duke.edu RI Ponikowski, Piotr/O-6454-2015 OI Ponikowski, Piotr/0000-0002-3391-7064 FU Trevena, Inc.; National Heart, Lung, and Blood Institute; Novartis; Roche Diagnostics; Otsuka; Amgen; National Institutes of Health (NIH); European Union; Health Resources Service Administration; NIH/National Heart, Lung, and Blood Institute; Cardiorentis; Abbott Point-of-Care; Medicines Company; Astellas; Intersection Medical; Radiometer; Medtronic; Trevena; Bayer; Cardio3Bioscience; Cytokinetics; Department of Veterans Affairs; Duke Clinical Research Institute; Janssen; Mast Therapeutics; Sorbent; St. Jude Medical FX The BLAST-AHF study is funded by Trevena, Inc. Dr. Felker has received grant support from the National Heart, Lung, and Blood Institute, Novartis, Roche Diagnostics, Otsuka, and Amgen; and has served as a consultant to Trevena, Amgen, Novartis, Celladon, Sorbent, Bristol-Myers Squibb, Singulex, St. Jude Medical, and Medtronic. Dr. Butler has received research support from the National Institutes of Health (NIH), European Union, and Health Resources Service Administration; and is a consultant to Amgen, Bayer, BG Medicine, Cardiocell, Celladon, GE Healthcare, Medtronic, Novartis, Ono Pharma, Otsuka, Takeda, Trevena, and Zensun. Dr. Collins has received research support from the NIH/National Heart, Lung, and Blood Institute, Cardiorentis, Abbott Point-of-Care, Novartis, The Medicines Company, Astellas, Intersection Medical, Radiometer, and Medtronic; and has served as a consultant to Trevena, Novartis, Cardiorentis, Otsuka, Radiometer, The Medicines Company, Medtronic, Intersection Medical, Cardioxyl, and Abbott Point-of-Care. Drs. Cotter and Davison are employees of Momentum Research, Inc., which has received compensation for coordinating research activities or participated in the design of research programs for Merck, Corthera Inc., Novartis Inc., Nile Therapeutics Inc., Amgen/Cytokinetics Inc., Travena Inc., Cardio3 Inc., Sorbent Inc., Chan Rx Inc.; and has received grants from not-for-profit nongovernmental organizations and the NIH. Dr. Davison has received honoraria from Novartis. Dr. Ezekowitz is codirector of the Canadian VIGOUR Centre, which is involved in site-management for the BLAST-AHF study. Dr. Filippatos has served on the executive committee of acute heart failure studies sponsored by Trevena, Novartis, Bayer, and Cardiorentis. Dr. Levy has served as a consultant for Trevena, Novartis, and Cardiorentis. Dr. Metra has served as a consultant for Bayer, Novartis, Servier, and Trevena. Drs. Ponikowski and Voors have served as a consultant for Trevena. Drs. Soergel and Violin are employees of Trevena. Dr. Teerlink has received research grants and/or consultant fees from Amgen, Cardio3Bioscience, Cytokinetics, Department of Veterans Affairs, Duke Clinical Research Institute, Janssen, Medtronic, Mast Therapeutics, Novartis, Sorbent, St. Jude Medical, and Trevena. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. NR 39 TC 29 Z9 29 U1 1 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 2213-1779 EI 2213-1787 J9 JACC-HEART FAIL JI JACC-Heart Fail. PD MAR PY 2015 VL 3 IS 3 BP 193 EP 201 DI 10.1016/j.jchf.2014.09.008 PG 9 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA CX4EC UT WOS:000365650600001 PM 25650371 ER PT J AU Naggie, S Patel, K Yang, LY Chow, SC Johnson, V Guyton, JR Muir, AJ Sulkowski, M Hicks, C AF Naggie, Susanna Patel, Keyur Yang, Lan-Yan Chow, Shein-Chung Johnson, Victoria Guyton, John R. Muir, Andrew J. Sulkowski, Mark Hicks, Charles TI Antiretroviral Effects on Host Lipoproteins Are Associated With Changes in Hepatitis C Virus (HCV) RNA Levels in Human Immunodeficiency Virus/HCV Coinfected Individuals SO OPEN FORUM INFECTIOUS DISEASES LA English DT Article DE apolipoprotein CIII; apolipoproteins; HCV; HCV RNA; HIV; lipoproteins ID HIV; INFECTION; THERAPY AB We evaluated the impact of antiretroviral-induced dyslipidemia on hepatitis C virus (HCV) biogenesis in human immunodeficiency virus (HIV)/HCV coinfected patients. This study used serum samples from antiretroviral-naive HIV/HCV patients initiating their first regimen as part of AIDS Clinical Trials Group study protocols (A5142, A5202). Initiation of antiretrovirals increased most lipoproteins and apolipoproteins. In the multivariable model, changes in apolipoproteins were associated with changes in log(10) HCV RNA from baseline to week-24 of therapy. Off-target lipogenic changes need to be considered in the context of liver and other metabolic disease in HIV/HCV patients. C1 [Naggie, Susanna; Patel, Keyur; Muir, Andrew J.] Duke Clin Res Inst, Durham, NC USA. [Naggie, Susanna; Patel, Keyur; Guyton, John R.; Muir, Andrew J.] Duke Univ, Med Ctr, Durham, NC USA. [Yang, Lan-Yan; Chow, Shein-Chung] Duke Dept Biostat & Bioinformat, Durham, NC USA. [Yang, Lan-Yan] Chang Gung Mem Hosp, Clin Trial Ctr, Taoyuan, Taiwan. [Johnson, Victoria] Birmingham VA Med Ctr, Birmingham, AL USA. [Johnson, Victoria] Univ Alabama, Tuscaloosa, AL 35487 USA. [Sulkowski, Mark] Johns Hopkins Univ, Baltimore, MD USA. [Hicks, Charles] Univ Calif San Diego, La Jolla, CA 92093 USA. RP Naggie, S (reprint author), 2400 Pratt St,Rm 0311,Terrace Level, Durham, NC 27705 USA. EM susanna.naggie@duke.edu NR 14 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 2328-8957 J9 OPEN FORUM INFECT DI JI Open Forum Infect. Dis. PD SPR PY 2015 VL 2 IS 2 DI 10.1093/ofid/ofv066 PG 5 WC Infectious Diseases SC Infectious Diseases GA CX6BM UT WOS:000365786200035 ER PT J AU Byne, W AF Byne, William TI LGBT Health: Going Strong as We Begin Our Second Year SO LGBT HEALTH LA English DT Editorial Material DE cancer; Department of Health and Human Services (HHS); disorders of sex development (DSD); Institute of Medicine (IOM); intersex; LGBT health; LGBT rights; National Institutes of Health (NIH); pre-exposure prophylaxis (PrEP) C1 [Byne, William] Icahn Sch Med, Dept Psychiat, Bronx, NY USA. [Byne, William] James J Peters VAMC, Bronx, NY 10467 USA. RP Byne, W (reprint author), James J Peters VAMC, Dept Psychiat, Res Bldg,Room 2F39,130 West Kingsbridge Rd, Bronx, NY 10467 USA. EM william.byne@mssm.edu NR 2 TC 0 Z9 0 U1 3 U2 3 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 2325-8292 EI 2325-8306 J9 LGBT HEALTH JI LGBT Health PD MAR PY 2015 VL 2 IS 1 BP 1 EP 2 DI 10.1089/lgbt.2015.0010 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CR9QU UT WOS:000361692500001 PM 26790010 ER PT J AU Byne, W Reiner, W AF Byne, William Reiner, William TI Interview with William Reiner, MD, Urologist and Child Psychiatrist, on Approaches to Care for Individuals with Disorders of Sex Development and Somatic Intersex Conditions SO LGBT HEALTH LA English DT Editorial Material DE assigned gender; disorders of sex development (DSD); intersex; optimal gender policy C1 [Byne, William] Icahn Sch Med, Dept Psychiat, Bronx, NY USA. [Byne, William] James J Peters VA Med Ctr, Bronx, NY 10467 USA. [Reiner, William] Univ Oklahoma, Hlth Sci Ctr, Dept Pediat Urol, Pediat Urol, Oklahoma City, OK USA. RP Byne, W (reprint author), James J Peters VAMC, Dept Psychiat, Res Bldg,Room 2F39,130 West Kingsbridge Rd, Bronx, NY 10467 USA. EM william.byne@mssm.edu NR 0 TC 0 Z9 0 U1 1 U2 3 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 2325-8292 EI 2325-8306 J9 LGBT HEALTH JI LGBT Health PD MAR PY 2015 VL 2 IS 1 BP 3 EP 10 DI 10.1089/lgbt.2015.0008 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CR9QU UT WOS:000361692500002 ER PT J AU Kopacz, MS Connery, AL AF Kopacz, Marek S. Connery, April L. TI The Veteran Spiritual Struggle SO SPIRITUALITY IN CLINICAL PRACTICE LA English DT Article DE service members; spirituality; suicide; veterans ID POSTTRAUMATIC-STRESS-DISORDER; MILITARY VETERANS; SUICIDAL IDEATION; VIETNAM VETERANS; COMBAT VETERANS; WAR VETERANS; DEPRESSION; GUILT; RISK; PTSD AB Although a considerable body of literature has been devoted to examining the physical, psychological, and social needs of veterans after their return from deployment, relatively little is known about the spiritual struggles some veterans face. In this article, we review what we know about this spiritual struggle, highlight the relevance of spirituality in clinical practice, and show examples of how a veteran's spiritual struggle may simultaneously present alongside different suicide risk factors. Suggestions for handling this spiritual struggle are then made. C1 [Kopacz, Marek S.] US Dept Vet Affairs, VISN Ctr Excellence Suicide Prevent 2, Canandaigua, NY 14424 USA. [Connery, April L.] US Dept Vet Affairs, Canandaigua VA Med Ctr, Canandaigua, NY 14424 USA. RP Kopacz, MS (reprint author), US Dept Vet Affairs, VISN Ctr Excellence Suicide Prevent 2, 400 Ft Hill Ave, Canandaigua, NY 14424 USA. EM marek.kopacz@va.gov NR 75 TC 4 Z9 4 U1 0 U2 1 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 2326-4500 EI 2326-4519 J9 SPIRITUAL CLIN PRACT JI Spiritual. Clin. Pract. PD MAR PY 2015 VL 2 IS 1 BP 61 EP 67 DI 10.1037/scp0000059 PG 7 WC Psychology, Clinical SC Psychology GA CL5BJ UT WOS:000356974500010 ER PT J AU Kopacz, MS AF Kopacz, Marek S. TI Spirituality and Suicide Prevention: Charting a Course for Research and Clinical Practice SO SPIRITUALITY IN CLINICAL PRACTICE LA English DT Editorial Material DE service members; spirituality; suicide prevention; veterans ID MEDICINE AB In their commentary, Bryan, Graham, and Roberge (2015) examine how spirituality can be conceptualized as a protective factor against suicide. The commentary submitted by Currier, Kuhlman, and Smith (2015) offers a review of the extant literature examining the relationship between spirituality and suicidal behavior as well as several ethical considerations related to applying spirituality in clinical practice. The present article looks to add to these discussions by providing further insight into understandings of spirituality as well as suggest additional steps which could be useful in developing the applicability of spirituality to suicide prevention efforts targeting current and former military personnel. C1 US Dept Vet Affairs, VISN Ctr Excellence Suicide Prevent 2, Canandaigua, NY 14424 USA. RP Kopacz, MS (reprint author), US Dept Vet Affairs, VISN Ctr Excellence Suicide Prevent 2, 400 Ft Hill Ave, Canandaigua, NY 14424 USA. EM marek.kopacz@va.gov NR 7 TC 0 Z9 0 U1 1 U2 1 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 2326-4500 EI 2326-4519 J9 SPIRITUAL CLIN PRACT JI Spiritual. Clin. Pract. PD MAR PY 2015 VL 2 IS 1 BP 79 EP 81 DI 10.1037/scp0000062 PG 3 WC Psychology, Clinical SC Psychology GA CL5BJ UT WOS:000356974500013 ER PT J AU Yoon, J Liu, CF Lo, J Schectman, G Stark, R Rubenstein, LV Yano, EM AF Yoon, Jean Liu, Chuan-Fen Lo, Jeanie Schectman, Gordon Stark, Richard Rubenstein, Lisa V. Yano, Elizabeth M. TI Early Changes in VA Medical Home Components and Utilization SO AMERICAN JOURNAL OF MANAGED CARE LA English DT Article ID CLINICS AB Objectives: In 2010, the Veterans Health Administration (VA) began national implementation of its patient-centered medical home (PCMH) model, called Patient Aligned Care Teams (PACTs), to improve access, coordination, and patient-centered care. We evaluated changes in reported implementation of PCMH components in all VA primary care clinics, and patients' utilization of acute and non-acute care and total costs after 2 years. Study Design: Longitudinal study of 2,607,902 patients from 796 VA primary care clinics. Methods: Clinics were surveyed for their implementation of PCMH components. Patient outcomes were measured by outpatient visits for primary care, specialty care, telephone care, and emergency department (ED) care; hospitalizations for an ambulatory care-sensitive condition (ACSC); and costs of VA care in fiscal years (FYs) 2009 and 2011. Multi-level, multivariable models predicted changes in utilization and costs, adjusting for patients' health status, clinic PCMH component scores, and a patient fixed effect. Results: Clinics reported large improvements in adoption of all PCMH components from FY 2009 to FY 2011. Higher organization of practice scores was associated with fewer primary care visits (P =.012). Greater care coordination/transitions was modestly associated with more specialty care visits (P =.010) and fewer ED visits (P =.018), but quality/performance improvement was associated with more ED visits (P =.032). None of the PCMH components were significantly related to telephone visits, ACSC hospitalizations, or total healthcare costs. Conclusions: Improvements under organization of practice and care coordination/transitions appear to have impacted outpatient care, but reductions in acute care were largely absent. C1 [Yoon, Jean; Lo, Jeanie] VA Palo Alto Hlth Care Syst, Hlth Econ Resource Ctr, Menlo Pk, CA USA. [Yoon, Jean] VA Palo Alto Hlth Care Syst, Ctr Innovat Implementat, Menlo Pk, CA USA. [Liu, Chuan-Fen] VA Puget Sound, Ctr Innovat Vet Ctr & Value Driven Care, Seattle, WA USA. [Liu, Chuan-Fen] Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA. [Schectman, Gordon; Stark, Richard] Vet Hlth Adm, Patient Care Serv, Washington, DC USA. [Rubenstein, Lisa V.; Yano, Elizabeth M.] VA Greater Los Angeles, Ctr Innovat Study Healthcare Innovat Implementat, Sepulveda, CA USA. [Rubenstein, Lisa V.] RAND Corp, Santa Monica, CA USA. [Rubenstein, Lisa V.; Yano, Elizabeth M.] Univ Calif Los Angeles, Dept Hlth Policy & Management, Fielding Sch Publ Hlth, Los Angeles, CA USA. [Rubenstein, Lisa V.] Univ Calif Los Angeles, Sch Med, Los Angeles, CA USA. RP Yoon, J (reprint author), 795 Willow Rd,152 MPD, Menlo Pk, CA 94025 USA. EM jean.yoon@va.gov FU Department of Veterans Affairs, Veterans Health Administration, Patient Care Services [XVA 65-018]; VA HSRD [RCS 05-195] FX This work was supported by the Department of Veterans Affairs, Veterans Health Administration, Patient Care Services (XVA 65-018). Dr Yano's effort was covered by a VA HSR&D Senior Research Career Scientist Award (Project #RCS 05-195). The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs or the United States federal government. NR 14 TC 1 Z9 1 U1 1 U2 2 PU MANAGED CARE & HEALTHCARE COMMUNICATIONS LLC PI PLAINSBORO PA 666 PLAINSBORO RD, STE 300, PLAINSBORO, NJ 08536 USA SN 1088-0224 J9 AM J MANAG CARE JI Am. J. Manag. Care PD MAR PY 2015 VL 21 IS 3 BP 197 EP U142 PG 9 WC Health Care Sciences & Services; Health Policy & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA CN7YF UT WOS:000358651300011 PM 25880624 ER PT J AU Graff, JN Baciarello, G Armstrong, AJ Higano, CS Iversen, P Forer, D Mansbach, HH Phung, D Tombal, BF Beer, TM Sternberg, CN AF Graff, Julie Nicole Baciarello, Giulia Armstrong, Andrew J. Higano, Celestia S. Iversen, Peter Forer, David Mansbach, Harry H. Phung, De Tombal, Bertrand F. Beer, Tomasz M. Sternberg, Cora N. TI Clinical outcomes and safety in men >= 75 and < 75 years with metastatic castration-resistant prostate cancer (mCRPC) treated with enzalutamide in the phase 3 PREVAIL trial. SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract CT Genitourinary Cancers Symposium CY FEB 26-28, 2015 CL Orlando, FL C1 Portland VA Med Ctr, OHSU Knight Canc Inst, Portland, OR USA. Grand Paris, Dept Canc Med, Gustave Roussy, Villejuif, France. Duke Univ, Durham, NC USA. Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. Copenhagen Univ Hosp, Rigshosp, Copenhagen, Denmark. Medivation Inc, San Francisco, CA USA. Astellas Pharma Global Dev Inc, Leiderdorp, Netherlands. Clin Univ St Luc, Div Urol, B-1200 Brussels, Belgium. Oregon Hlth & Sci Univ, OHSU Knight Canc Inst, Portland, OR 97201 USA. Hosp San Camillo Forlanini, Rome, Italy. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAR 1 PY 2015 VL 33 IS 7 SU S MA 200 PG 1 WC Oncology SC Oncology GA CL3XX UT WOS:000356886700201 ER PT J AU McGinley, KF Sun, XZ Howard, LE Aronson, WJ Terris, MK Kane, CJ Amling, CL Cooperberg, MR Freedland, SJ AF McGinley, Kathleen F. Sun, Xizi Howard, Lauren E. Aronson, William J. Terris, Martha K. Kane, Christopher J. Amling, Christopher L. Cooperberg, Matthew R. Freedland, Stephen J. TI Utilization and impact of surgical technique on the performance of pelvic lymph node dissection at radical prostatectomy: Results from the SEARCH database. SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract CT Genitourinary Cancers Symposium CY FEB 26-28, 2015 CL Orlando, FL C1 Duke Univ, Med Ctr, Durham, NC USA. Duke Univ, Durham VA Med Ctr, Durham, NC USA. Duke Univ, Durham VA Med Ctr, Dept Biostat & Bioinformat, Durham, NC USA. Univ Calif Los Angeles, VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. Georgia Regents Univ, Med Coll Georgia, Charles Norwood VA Med Ctr, Augusta, GA USA. Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA. Oregon Hlth & Sci Univ, Portland, OR 97201 USA. Univ Calif San Francisco, San Francisco, CA 94143 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAR 1 PY 2015 VL 33 IS 7 SU S MA 73 PG 1 WC Oncology SC Oncology GA CL3XX UT WOS:000356886700074 ER PT J AU McGinley, KF Sun, XZ Howard, LE Aronson, WJ Terris, MK Kane, CJ Amling, CL Cooperberg, MR Freedland, SJ AF McGinley, Kathleen F. Sun, Xizi Howard, Lauren E. Aronson, William J. Terris, Martha K. Kane, Christopher J. Amling, Christopher L. Cooperberg, Matthew R. Freedland, Stephen J. TI Can Gleason 7 prostate cancer ever be low-risk? Results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database. SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract CT Genitourinary Cancers Symposium CY FEB 26-28, 2015 CL Orlando, FL C1 Duke Univ, Med Ctr, Durham, NC USA. Duke Univ, Durham VA Med Ctr, Durham, NC USA. Duke Univ, Durham VA Med Ctr, Dept Biostat & Bioinformat, Durham, NC USA. Univ Calif Los Angeles, VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. Georgia Regents Univ, Charles Norwood VA Med Ctr, Med Coll Georgia, Augusta, GA USA. Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA. Oregon Hlth & Sci Univ, Portland, OR 97201 USA. Univ Calif San Francisco, San Francisco, CA 94143 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAR 1 PY 2015 VL 33 IS 7 SU S MA 57 PG 1 WC Oncology SC Oncology GA CL3XX UT WOS:000356886700058 ER PT J AU Callen, J Giardina, TD Singh, H Li, L Paoloni, R Georgiou, A Runciman, WB Westbrook, JI AF Callen, Joanne Giardina, Traber Davis Singh, Hardeep Li, Ling Paoloni, Richard Georgiou, Andrew Runciman, William B. Westbrook, Johanna I. TI Emergency Physicians' Views of Direct Notification of Laboratory and Radiology Results to Patients Using the Internet: A Multisite Survey SO JOURNAL OF MEDICAL INTERNET RESEARCH LA English DT Article DE Internet; patient safety; electronic health records; patient empowerment; diagnostic tests; emergency care; radiology ID RANDOMIZED CONTROLLED-TRIAL; CLOSED MALPRACTICE CLAIMS; ELECTRONIC MEDICAL-RECORD; E-MAIL; DELAYED DIAGNOSES; INVITING PATIENTS; ENHANCE PATIENT; CANCER-PATIENTS; YOUNG-PATIENTS; DOCTORS NOTES AB Background: Patients are increasingly using the Internet to communicate with health care providers and access general and personal health information. Missed test results have been identified as a critical safety issue with studies showing up to 75% of tests for emergency department (ED) patients not being followed-up. One strategy that could reduce the likelihood of important results being missed is for ED patients to have direct access to their test results. This could be achieved electronically using a patient portal tied to the hospital's electronic medical record or accessed from the relevant laboratory information system. Patients have expressed interest in accessing test results directly, but there have been no reported studies on emergency physicians' opinions. Objective: The aim was to explore emergency physicians' current practices of test result notification and attitudes to direct patient notification of clinically significant abnormal and normal test results. Methods: A cross-sectional survey was self-administered by senior emergency physicians (site A: n=50; site B: n=39) at 2 large public metropolitan teaching hospitals in Australia. Outcome measures included current practices for notification of results (timing, methods, and responsibilities) and concerns with direct notification. Results: The response rate was 69% (61/89). More than half of the emergency physicians (54%, 33/61) were uncomfortable with patients receiving direct notification of abnormal test results. A similar proportion (57%, 35/61) was comfortable with direct notification of normal test results. Physicians were more likely to agree with direct notification of normal test results if they believed it would reduce their workload (OR 5.72, 95% CI 1.14-39.76). Main concerns were that patients could be anxious (85%, 52/61), confused (92%, 56/61), and lacking in the necessary expertise to interpret their results (90%, 55/61). Conclusions: Although patients' direct access to test results could serve as a safety net reducing the likelihood of abnormal results being missed, emergency physicians' concerns need further exploration: which results are suitable and the timing and method of direct release to patients. Methods of access, including secure Web-based patient portals with drill-down facilities providing test descriptions and result interpretations, or laboratories sending results directly to patients, need evaluation to ensure patient safety is not compromised and the processes fit with ED clinician and laboratory work practices and patient needs. C1 [Callen, Joanne; Li, Ling; Georgiou, Andrew; Westbrook, Johanna I.] Macquarie Univ, Australian Inst Hlth Innovat, Ctr Hlth Syst & Safety Res, Sydney, NSW 2109, Australia. [Giardina, Traber Davis; Singh, Hardeep] Baylor Coll Med, Houston VA HSR&D Ctr Innovat Qual Effectiveness &, Michael E DeBakey Vet Affairs Med Ctr, Dept Med, Houston, TX 77030 USA. [Paoloni, Richard] Concord Repatriat & Gen Hosp, Emergency Dept, Sydney, NSW, Australia. [Runciman, William B.] Univ Adelaide, Dept Anaesthesia & Intens Care, Joanna Briggs Inst, Adelaide, SA, Australia. RP Callen, J (reprint author), Macquarie Univ, Australian Inst Hlth Innovat, Ctr Hlth Syst & Safety Res, Level 6,75 Talavera Rd, Sydney, NSW 2109, Australia. EM joanne.callen@mq.edu.au OI Runciman, William (Bill)/0000-0001-8489-0693 FU Australian Research Council [DP120100297]; VA Health Services through the VA Office of Academic Affiliations; VA Health Services Research and Development Service [CRE 12-033]; VA National Center for Patient Safety; Agency for Health Care Research and Quality [R01HS022087]; Houston VA HSR&D Center for Innovations in Quality, Effectiveness and Safety [CIN 13-413, 14-274] FX We would like to acknowledge the contributions of Louise Robertson, Michael Stewart, Julie Li, George Touli, and Elia Vecellio. This study is part of an Australian Research Council Discovery Project Grant (DP120100297) to investigate whether technology can make communication in complex systems safer and more efficient.; Dr Giardina is supported by the VA Health Services Research postdoctoral fellowship through the VA Office of Academic Affiliations. Dr Singh is supported by the VA Health Services Research and Development Service (CRE 12-033; Presidential Early Career Award for Scientists and Engineers USA 14-274), the VA National Center for Patient Safety and the Agency for Health Care Research and Quality (R01HS022087). This work is also supported in part by the Houston VA HSR&D Center for Innovations in Quality, Effectiveness and Safety (CIN 13-413). NR 67 TC 2 Z9 2 U1 3 U2 10 PU JMIR PUBLICATIONS, INC PI TORONTO PA 59 WINNERS CIRCLE, TORONTO, ON M4L 3Y7, CANADA SN 1438-8871 J9 J MED INTERNET RES JI J. Med. Internet Res. PD MAR PY 2015 VL 17 IS 3 AR e60 DI 10.2196/jmir.3721 PG 13 WC Health Care Sciences & Services; Medical Informatics SC Health Care Sciences & Services; Medical Informatics GA CL2NJ UT WOS:000356780900003 PM 25739322 ER PT J AU Bossarte, R AF Bossarte, Robert TI Enhancing Surveillance of Suicide Ideation and Suicide Attempt Through Integration of Data from Multiple Systems SO PSYCHIATRY-INTERPERSONAL AND BIOLOGICAL PROCESSES LA English DT Article ID PREVENTION; RISK C1 [Bossarte, Robert] US Dept Vet Affairs, Off Publ Hlth, Rochester, NY USA. RP Bossarte, R (reprint author), Univ Rochester, Off Publ Hlth, US Dept Vet Affairs, Dept Psychiat,Sch Med & Dent, Rochester, NY 14642 USA. EM Robert.Bossarte@va.gov NR 9 TC 0 Z9 0 U1 3 U2 4 PU GUILFORD PUBLICATIONS INC PI NEW YORK PA 370 SEVENTH AVE, SUITE 1200, NEW YORK, NY 10001-1020 USA SN 0033-2747 J9 PSYCHIATRY JI Psychiatry-Interpers. Biol. Process. PD SPR PY 2015 VL 78 IS 1 BP 22 EP 24 DI 10.1080/00332747.2015.1021657 PG 3 WC Psychiatry SC Psychiatry GA CK6DN UT WOS:000356318800002 PM 26168023 ER PT J AU Johnson, RS Stolar, AG Wu, E Coonan, LA Graham, DP AF Johnson, R. Scott Stolar, Andrea G. Wu, Emily Coonan, Loretta A. Graham, David P. TI An analysis of successful outcomes and associated contributing factors in veterans' court SO BULLETIN OF THE MENNINGER CLINIC LA English DT Article ID DRUG AB This study aims to examine the extent to which a veteran's propensity for arrest following separation from veterans' court is associated with that veteran's length of stay within the program, type of discharge, or number of judicial sanctions issued. This is a retrospective chart review that focuses on the first 100 participants in the Harris County Veterans' Court Program. After controlling for a number of demographic factors, both arrests during enrollment in the veterans' court program (p = .031) and Factor Score 1 (unsuccessful discharge, fewer months in the veterans' court program, and more months of follow up) (p = .042) were predictive of arrest following separation from the veterans' court program. In addition, a prior diagnosis of opiate misuse was also predictive of arrest following separation (p < .001). Given these findings, veterans' court judges and program administrators might examine ways of continuing enrollment for veterans at highest risk for recidivism. C1 [Johnson, R. Scott] Michael E DeBakey Vet Affairs VA Med Ctr, Mental Hlth Care Line, Houston, TX USA. [Johnson, R. Scott] Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA. [Stolar, Andrea G.; Graham, David P.] Baylor Coll Med, Psychiat, Houston, TX 77030 USA. [Wu, Emily] Baylor Coll Med, Houston, TX 77030 USA. [Coonan, Loretta A.] Michael E DeBakey Med Ctr, Houston, TX USA. [Graham, David P.] Michael E DeBakey VA Med Ctr, Houston, TX USA. [Graham, David P.] Michael E DeBakey VA Med Ctr, Neurorehabil Neurons Networks Traumat Brain Injur, Houston, TX USA. RP Johnson, RS (reprint author), 1977 Butler Blvd,Suite E4-400, Houston, TX 77030 USA. EM rscottjohnson3@gmail.com NR 5 TC 2 Z9 2 U1 0 U2 1 PU GUILFORD PUBLICATIONS INC PI NEW YORK PA 370 SEVENTH AVE, SUITE 1200, NEW YORK, NY 10001-1020 USA SN 0025-9284 EI 1943-2828 J9 B MENNINGER CLIN JI Bull. Menninger Clin. PD SPR PY 2015 VL 79 IS 2 BP 166 EP 173 PG 8 WC Psychiatry; Psychology, Psychoanalysis SC Psychiatry; Psychology GA CJ7RD UT WOS:000355695000004 PM 26035089 ER PT J AU Mitchell, AM Stone, AEL Cheng, LL Ballinger, K Edwards, MG Stoddard, M Li, H Golden-Mason, L Shaw, GM Khetani, S Rosen, HR AF Mitchell, Angela M. Stone, Amy E. L. Cheng, Linling Ballinger, Kimberly Edwards, Michael G. Stoddard, Mark Li, Hui Golden-Mason, Lucy Shaw, George M. Khetani, Salman Rosen, Hugo R. TI Transmitted/Founder Hepatitis C Viruses Induce Cell-Type- and Genotype-Specific Differences in Innate Signaling within the Liver SO MBIO LA English DT Article ID PLASMACYTOID DENDRITIC CELLS; INFECTION; INTERFERON; CANCER; HCV; IDENTIFICATION; REPLICATION; STEATOSIS; CLEARANCE; FIBROSIS AB Hepatitis C virus (HCV) infection leads to persistence in the majority of cases despite triggering complex innate immune responses within the liver. Although hepatocytes are the preferred site for HCV replication, nonparenchymal cells (NPCs) can also contribute to antiviral immunity. Recent innovations involving single-genome amplification (SGA), direct amplicon sequencing, and phylogenetic inference have identified full-length transmitted/founder (T/F) viruses. Here, we tested the effect of HCV T/F viral RNA (vRNA) on innate immune signaling within hepatocytes and NPCs, including the HepG2 and Huh 7.5.1 cell lines, a human liver endothelial cell line (TMNK-1), a plasmacytoid dendritic cell line (GEN2.2), and a monocytic cell line (THP-1). Transfection with hepatitis C T/F vRNA induced robust transcriptional upregulation of type I and III interferons (IFNs) within HepG2 and TMNK-1 cells. Both the THP-1 and GEN2.2 lines demonstrated higher type I and III IFN transcription with genotype 3a compared to genotype 1a or 1b. Supernatants from HCV T/F vRNA-transfected TMNK-1 cells demonstrated superior viral control. Primary human hepatocytes (PHH) transfected with genotype 3a induced canonical pathways that included chemokine and IFN genes, as well as overrepresentation of RIG-I (DDX58), STAT1, and a Toll-like receptor 3 (TLR3) network. Full-length molecular clones of HCV induce broad IFN responses within hepatocytes and NPCs, highlighting that signals imparted by the various cell types within the liver may lead to divergent outcomes of infection. In particular, the finding that HCV genotypes differentially induce antiviral responses in NPCs and PHH might account for relevant clinical-epidemiological observations (higher clearance but greater necroinflammation in persistence with genotype 3). IMPORTANCE Hepatitis C virus (HCV) has become a major worldwide problem, and it is now the most common viral infection for which there is no vaccine. HCV infection often leads to persistence of the virus and is a leading cause of chronic hepatitis, liver cancer, and cirrhosis. There are multiple genotypes of the virus, and patients infected with different viral genotypes respond to traditional therapy differently. However, the immune response to the virus within the liver has not been fully elucidated. Here, we determined the responses to different genotypes of HCV in cell types of the liver. We found that the immune response varied according to both cell type and HCV genotype, leading to a more pronounced induction of inflammatory pathways after exposure to certain genotypes. Therefore, inflammatory pathways that are being robustly activated by certain HCV genotypes could lead to more severe damage to the liver, inducing diverse outcomes and responses to therapy. C1 [Mitchell, Angela M.; Stone, Amy E. L.; Golden-Mason, Lucy; Rosen, Hugo R.] Univ Colorado Denver, Integrated Dept Immunol, Denver, CO 80204 USA. [Mitchell, Angela M.; Stone, Amy E. L.; Golden-Mason, Lucy; Rosen, Hugo R.] Natl Jewish Hlth, Denver, CO USA. [Mitchell, Angela M.; Stone, Amy E. L.; Cheng, Linling; Golden-Mason, Lucy; Rosen, Hugo R.] Univ Colorado Denver, Div Gastroenterol & Hepatol, Hepatitis Ctr C, Dept Med, Denver, CO USA. [Ballinger, Kimberly; Khetani, Salman] Colorado State Univ, Mech & Biomed Engn, Ft Collins, CO 80523 USA. [Edwards, Michael G.] Univ Colorado Denver, Dept Med, Div Pulm Sci & Crit Care Med, Aurora, CO USA. [Stoddard, Mark; Li, Hui; Shaw, George M.] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA. [Rosen, Hugo R.] Denver Vet Affairs Med Ctr, Denver, CO USA. RP Rosen, HR (reprint author), Univ Colorado Denver, Integrated Dept Immunol, Denver, CO 80204 USA. EM hugo.rosen@ucdenver.edu FU National Institutes of Health [R21 AI 103361, R21-AI 106000]; HCV Center [U19 AI 1066328]; VA Merit Review grant (Department of Veteran's Affairs) FX This work was supported by R21 AI 103361 (National Institutes of Health), U19 AI 1066328 (HCV Center grant), and a VA Merit Review grant (Department of Veteran's Affairs) to H.R.R. and R21-AI 106000 (National Institutes of Health) to G.M.S. NR 46 TC 3 Z9 3 U1 2 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 2150-7511 J9 MBIO JI mBio PD MAR-APR PY 2015 VL 6 IS 2 AR e02510-14 DI 10.1128/mBio.02510-14 PG 11 WC Microbiology SC Microbiology GA CJ2KE UT WOS:000355312400065 PM 25714713 ER PT J AU Sher, L AF Sher, Leo TI Suicide in Men SO JOURNAL OF CLINICAL PSYCHIATRY LA English DT Editorial Material ID OF-THE-LITERATURE; TESTOSTERONE LEVELS; BIPOLAR DISORDER; BEHAVIOR; LITHIUM; GENDER; IMPULSIVITY C1 [Sher, Leo] James J Peters Vet Adm Med Ctr, New York, NY 10468 USA. [Sher, Leo] Icahn Sch Med Mt Sinai, New York, NY 10029 USA. RP Sher, L (reprint author), James J Peters Vet Adm Med Ctr, 130 West Kingsbridge Rd, New York, NY 10468 USA. EM Leo.Sher@mssm.edu NR 21 TC 3 Z9 3 U1 2 U2 11 PU PHYSICIANS POSTGRADUATE PRESS PI MEMPHIS PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA SN 0160-6689 EI 1555-2101 J9 J CLIN PSYCHIAT JI J. Clin. Psychiatry PD MAR PY 2015 VL 76 IS 3 BP E371 EP E372 DI 10.4088/JCP.14com09554 PG 2 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA CI7PD UT WOS:000354955400008 PM 25830461 ER PT J AU Brennan, MB Barocas, JA Crnich, CJ Hess, TM Kolehmainen, CJ Sosman, JM Sethi, AK AF Brennan, Meghan B. Barocas, Joshua A. Crnich, Christopher J. Hess, Timothy M. Kolehmainen, Christine J. Sosman, James M. Sethi, Ajay K. TI "Oops! I forgot HIV": Resident physician self-audits and universal HIV screening SO JOURNAL OF INFECTION AND PUBLIC HEALTH LA English DT Article DE HIV screening; Self-audit feedback; Chart review; Medical resident education; Qualitative ID HEALTH-CARE SETTINGS; UNITED-STATES; ANTIRETROVIRAL THERAPY; RECOMMENDATIONS; PREVENTION; RISK; PREVALENCE; BEHAVIORS; VETERANS; ADULTS AB Background: Innovations are needed to increase universal HIV screening by primary care providers. One potential intervention is self-audit feedback, which describes the process of a clinician reviewing their own patient charts and reflecting on their performance. Methods: The effectiveness of self-audit feedback was investigated using a mixed methods approach. A total of 2111 patient charts were analyzed in a quantitative pre-post intervention study design, where the intervention was providing self-audit feedback to all internal medicine residents at one institution through an annual chart review. Qualitative data generated from the subsequent resident focus group discussions explored the motivation and mechanism for change using a knowledge attitude behavior framework. Results: The proportion of primary care patients screened for HIV increased from 17.9% (190/1060) to 40.3% (423/1051). The adjusted odds ratio of a patient being screened following resident self-audited feedback was 3.17 (95% Cl 2.11, 4.76, p < 0.001). Focus group participants attributed the improved performance to the self-audit feedback. Conclusions: Self-audit feedback is a potentially effective intervention for increasing universal HIV screening in primary care. This strategy may be most useful in settings where (1) baseline performance is low, (2) behavioral change is provider-driven, and (3) resident trainees are targeted. Published by Elsevier Limited on behalf of King Saud Bin Abdulaziz University for Health Sciences. C1 [Brennan, Meghan B.; Barocas, Joshua A.; Crnich, Christopher J.; Hess, Timothy M.; Kolehmainen, Christine J.; Sosman, James M.] Univ Wisconsin, Dept Med, Madison, WI 53705 USA. [Brennan, Meghan B.; Crnich, Christopher J.; Sethi, Ajay K.] Univ Wisconsin, Dept Populat Hlth Sci, Madison, WI 53726 USA. [Brennan, Meghan B.; Crnich, Christopher J.; Hess, Timothy M.; Kolehmainen, Christine J.] William S Middleton Mem Vet Adm Med Ctr, Madison, WI 53705 USA. RP Brennan, MB (reprint author), UWMF Centennial Bldg,5th Floor,1685 Highland Ave, Madison, WI 53705 USA. EM mbbrennan@medicine.wisc.edu; jbarocas@medicine.wisc.edu; cjc@medicine.wisc.edu; tmhess@medicine.wisc.edu; Christine.Kolehmainen@va.gov; jms@medicine.wisc.edu; aksethi@wisc.edu OI Crnich, Christopher/0000-0002-9320-9262 FU University of Wisconsin Department of Medicine; University of Wisconsin Department of Population Health Sciences; VA Advanced Women's Health Research Fellowship FX This study received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors. However, the authors did receive general support from the University of Wisconsin Departments of Medicine and Population Health Sciences and the VA Advanced Women's Health Research Fellowship. These sources did not have a role in study design; collection, analysis and interpretation of data; writing; or the decision to submit the article for publication. This is GRECC manuscript 2014-022. NR 34 TC 2 Z9 2 U1 2 U2 4 PU ELSEVIER SCIENCE LONDON PI LONDON PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND SN 1876-0341 EI 1876-035X J9 J INFECT PUBLIC HEAL JI J. Infect. Public Health PD MAR-APR PY 2015 VL 8 IS 2 BP 161 EP 169 DI 10.1016/j.jiph.2014.08.010 PG 9 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA CI7SK UT WOS:000354964700007 PM 25277258 ER PT J AU Pietrzak, RH Lim, YY Ames, D Harrington, K Restrepo, C Martins, RN Rembach, A Laws, SM Masters, CL Villemagne, VL Rowe, CC Maruff, P AF Pietrzak, Robert H. Lim, Yen Ying Ames, David Harrington, Karra Restrepo, Carolina Martins, Ralph N. Rembach, Alan Laws, Simon M. Masters, Colin L. Villemagne, Victor L. Rowe, Christopher C. Maruff, Paul CA Australian Imaging Biomarkers Life TI Trajectories of memory decline in preclinical Alzheimer's disease: results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing SO NEUROBIOLOGY OF AGING LA English DT Article DE Alzheimer's disease; Memory; Trajectories; A beta; APOE ID HEALTHY OLDER-ADULTS; MILD COGNITIVE IMPAIRMENT; AMYLOID-BETA; PROSPECTIVE COHORT; EPISODIC MEMORY; DEMENTIA; ASSOCIATION; AGE; DEPOSITION; ANXIETY AB Memory changes in preclinical Alzheimer's disease (AD) are often characterized by heterogenous trajectories. However, data regarding the nature and determinants of predominant trajectories of memory changes in preclinical AD are lacking. We analyzed data from 333 cognitively healthy older adults who participated in a multicenter prospective cohort study with baseline and 18-, 36-, and 54-month follow-up assessments. Latent growth mixture modeling revealed 3 predominant trajectories of memory change: a below average, subtly declining memory trajectory (30.9%); a below average, rapidly declining memory trajectory (3.6%); and an above average, stable memory trajectory (65.5%). Compared with the stable memory trajectory, high A beta (relative risk ratio [RRR] = 2.1), and lower Mini-Mental State Examination (RRR = 0.6) and full-scale IQ (RRR =0.9) scores were independently associated with the subtly declining memory trajectory; and high Ab (RRR = 8 .3), APOE epsilon 4 carriage (RRR = 6.1), and greater subjective memory impairment (RRR - 1.2) were independently associated with the rapidly declining memory trajectory. Compared with the subtly declining memory trajectory group, APOE epsilon 4 carriage (RRR = 8.4), and subjective memory complaints (RRR = 1.2) were associated with a rapidly declining memory trajectory. These results suggest that the preclinical phase of AD may be characterized by 2 predominant trajectories of memory decline that have common (e.g., high A beta) and unique (e.g., APOE epsilon 4 genotype) determinants. Published by Elsevier Inc. C1 [Pietrzak, Robert H.] US Dept Vet Affairs, Natl Ctr Posttraumat Stress Disorder, Clin Neurosci Div, VA Connecticut Healthcare Syst, West Haven, CT 06516 USA. [Pietrzak, Robert H.] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA. [Lim, Yen Ying; Harrington, Karra; Restrepo, Carolina; Rembach, Alan; Masters, Colin L.; Villemagne, Victor L.; Maruff, Paul] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic 3052, Australia. [Lim, Yen Ying] Brown Univ, Warren Alpert Sch Med, Dept Neurol, Providence, RI 02912 USA. [Ames, David] Univ Melbourne, Dept Psychiat, St Vincents Hlth, Acad Unit Psychiat Old Age, Kew, Vic, Australia. [Ames, David] Natl Ageing Res Inst, Parkville, Vic, Australia. [Martins, Ralph N.; Laws, Simon M.] Edith Cowan Univ, Sch Exercise Biomed & Hlth Sci, Ctr Excellence Alzheimers Dis Res & Care, Perth, WA, Australia. [Martins, Ralph N.; Laws, Simon M.] Hollywood Private Hosp, Sir James McCusker Alzheimers Dis Res Unit, Nedlands, WA, Australia. [Villemagne, Victor L.; Rowe, Christopher C.] Austin Hlth, Dept Nucl Med, Heidelberg, Vic, Australia. [Villemagne, Victor L.; Rowe, Christopher C.] Austin Hlth, Ctr PET, Heidelberg, Vic, Australia. [Villemagne, Victor L.; Rowe, Christopher C.] Univ Melbourne, Austin Hlth, Dept Med, Heidelberg, Vic, Australia. [Maruff, Paul] Cogstate Ltd, Melbourne, Vic, Australia. RP Pietrzak, RH (reprint author), US Dept Vet Affairs, Natl Ctr Posttraumat Stress Disorder, Clin Neurosci Div, VA Connecticut Healthcare Syst, 950 Campbell Ave 161E, West Haven, CT 06516 USA. EM robert.pietrzak@yale.edu RI Laws, Simon/C-2858-2014 OI Laws, Simon/0000-0002-4355-7082; Maruff, Paul/0000-0002-6947-9537 FU Commonwealth Scientific Industrial Research Organization (CSIRO); Edith Cowan University (ECU); Mental Health Research Institute (MHRI); National Ageing Research Institute (NARI); Austin Health; CogState Ltd.; National Health and Medical Research Council (NHMRC); Dementia Collaborative Research Centres program (DCRC2); Science and Industry Endowment Fund (SIEF); Cooperative Research Centre for Mental Health (CRCMH) FX Funding for the study was provided in part by the study partners [Commonwealth Scientific Industrial Research Organization (CSIRO), Edith Cowan University (ECU), Mental Health Research Institute (MHRI), National Ageing Research Institute (NARI), Austin Health, and CogState Ltd]. The study also received support from the National Health and Medical Research Council (NHMRC) and the Dementia Collaborative Research Centres program (DCRC2), as well as funding from the Science and Industry Endowment Fund (SIEF) and the Cooperative Research Centre for Mental Health (CRCMH). Robert H. Pietrzak, Yen Ying Lim, and Paul Maruff conceptualized the study design, reviewed the literature, and wrote the first draft of the article, and conducted data analyses; David Ames, Ralph N. Martins, Colin L. Masters, Paul Maruff, Victor L. Villemagne, Alan Rembach, Christopher C. Rowe are senior investigators of the AIBL study and responsible for the design of the AIBL study and selection of study endpoints. Victor L. Villemagne and Christopher C. Rowe conducted and oversaw neuroimaging for all participants. Yen Ying Lim and Karra Harrington conducted neuropsychological assessments. Simon M. Laws undertook genetic analyses for all participants. David Ames, Karra Harrington, Carolina Restrepo, Ralph N. Martins, Alan Rembach, Simon M. Laws, Colin L. Masters, Victor L. Villemagne, and Christopher C. Rowe provided critical revision of article drafts. NR 33 TC 17 Z9 17 U1 0 U2 10 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0197-4580 EI 1558-1497 J9 NEUROBIOL AGING JI Neurobiol. Aging PD MAR PY 2015 VL 36 IS 3 BP 1231 EP 1238 DI 10.1016/j.neurobiolaging.2014.12.015 PG 8 WC Geriatrics & Gerontology; Neurosciences SC Geriatrics & Gerontology; Neurosciences & Neurology GA CI1XJ UT WOS:000354538100001 PM 25585532 ER PT J AU Quinzanos, I Luong, PT Bobba, S Richards, JS Majithia, V Davis, LA Caplan, L AF Quinzanos, I. Luong, P. T. Bobba, S. Richards, J. Steuart Majithia, V. Davis, L. A. Caplan, L. TI Validation of disease activity and functional status questionnaires in spondyloarthritis SO CLINICAL AND EXPERIMENTAL RHEUMATOLOGY LA English DT Article DE ankylosing spondylitis; questionnaires; health impact assessment ID BATH ANKYLOSING-SPONDYLITIS; ACTIVITY INDEX; RELIABILITY; CRITERIA AB Objective Patients naive to the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and to the Ankylosing Spondylitis Disease Activity Score (ASDAS) have voiced confusion in our clinics over the use of the term "AS" in these instruments. It is unknown whether these tools may be applied to other related forms of spondyloarthritis (SpA). The Bath Ankylosing Spondylitis Functional Index (BASFI) questionnaire also requires more definitive validation. We I) validated the BASFI against a standard definition of disability; and 2) validated slightly modified versions of the BASDAI and ASDAS questionnaires that replace references to "AS" with the term "inflammatory arthritis" for use in non-AS SpA. Methods Adult patients with SpA enrolled in the Veterans Affairs Program to Understand the Longterm outcomes in Spondylo-ARthritis (PULSAR) completed the BASFI, BASDAL ASDAS and altered versions of the BASDAI (PULSAR-modified Bath Disease Activity Index [PuBaDAI]) and ASDAS (PULSAR-modified Ankylosing Spondylitis Disease Activity Score [PuASDAS]). Spearman correlations and logistic regression were used to analyse the scores. Results The correlation between BASDAI and PuBaDAI and between ASDAS and PuASDAS scores was high (Spearman rho=0.92, p<0.001 and Spearman's rho=0.85, p<0.001, respectively). The test-retest correlation of BASFI was also high (Spearman's rho=0.92, p<0.001). The BASFI (OR 1.67, 95% C.I. 1.12-2.47), ASDAS (OR 1.34, 95% C.I. 1.02-1.76) and PuASDAS (OR 1.62, 95% C.I. 1.07-2.49) predicted federally-determined disability. Conclusion Preliminary data suggest that BASDAI and ASDAS scores correlate well with modified forms of these questionnaires and that the ASDAS, PuASDAS and BASFI are associated with disability. C1 [Quinzanos, I.; Luong, P. T.; Bobba, S.; Davis, L. A.; Caplan, L.] Dept Vet Affairs, Denver, CO USA. [Quinzanos, I.; Davis, L. A.; Caplan, L.] Univ Colorado, Sch Med, Aurora, CO USA. [Richards, J. Steuart] Dept Vet Affairs, Washington, DC USA. [Majithia, V.] Montgomery VAMC, Jackson, MS USA. [Davis, L. A.] Denver Hlth, Denver, CO USA. RP Caplan, L (reprint author), Univ Colorado, Sch Med, Denver Vet Affairs Med Ctr, 1775 Aurora Ct,POB 6511,B115, Denver, CO 80045 USA. EM liron.caplan@ucdenver.edu FU VA HSR&D Career Development Award [07-221]; NIH/NIAMS [T32 AR007534-24]; VA GME Enhancement Award FX L. Caplan is supported by VA HSR&D Career Development Award (07-221); L.A. Davis was supported by NIH/NIAMS T32 AR007534-24 and a VA GME Enhancement Award during the time this research was conducted. NR 18 TC 3 Z9 3 U1 0 U2 0 PU CLINICAL & EXPER RHEUMATOLOGY PI PISA PA VIA SANTA MARIA 31, 56126 PISA, ITALY SN 0392-856X J9 CLIN EXP RHEUMATOL JI Clin. Exp. Rheumatol. PD MAR-APR PY 2015 VL 33 IS 2 BP 146 EP 152 PG 7 WC Rheumatology SC Rheumatology GA CG6TX UT WOS:000353436400003 PM 25664820 ER PT J AU Cai, HL Li, HD Yao, JK AF Cai, HuaLin Li, HuanDe Yao, Jeffrey K. TI A POTENTIAL MECHANISM UNDERLYING ATYPICAL ANTIPSYCHOTIC INDUCED LIPID DISTURBANCES SO SCHIZOPHRENIA BULLETIN LA English DT Meeting Abstract CT 15th International Congress on Schizophrenia Research (ICOSR) CY MAR 28-APR 01, 2015 CL Colorado Springs, CO C1 [Cai, HuaLin; Li, HuanDe] Cent S Univ, Xiangya Hosp 2, Changsha, Hunan, Peoples R China. [Cai, HuaLin; Yao, Jeffrey K.] Cent S Univ, Inst Clin Pharm, Changsha, Hunan, Peoples R China. [Cai, HuaLin; Yao, Jeffrey K.] Univ Pittsburgh, Dept Pharmaceut Sci, Pittsburgh, PA USA. [Cai, HuaLin; Yao, Jeffrey K.] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA. [Yao, Jeffrey K.] VA Pittsburgh Healthcare Syst, Med Res Serv, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0586-7614 EI 1745-1701 J9 SCHIZOPHRENIA BULL JI Schizophr. Bull. PD MAR PY 2015 VL 41 SU 1 MA 2095377 BP S124 EP S125 PG 2 WC Psychiatry SC Psychiatry GA CG8HO UT WOS:000353548200330 ER PT J AU Cortes-Briones, JA Cahill, JD Skosnik, PD Mathalon, DH Williams, A Sewell, RA Roach, BJ Ford, JM Ranganathan, M D'Souza, DC AF Cortes-Briones, Jose A. Cahill, John Daniel Skosnik, Patrick David Mathalon, Daniel H. Williams, Ashley Sewell, Richard Andrew Roach, Brian J. Ford, Judith M. Ranganathan, Mohini D'Souza, Deepak Cyril TI INCREASED NEURAL NOISE IS RELATED TO THE PSYCHOSIS-LIKE EFFECTS OF THC SO SCHIZOPHRENIA BULLETIN LA English DT Meeting Abstract CT 15th International Congress on Schizophrenia Research (ICOSR) CY MAR 28-APR 01, 2015 CL Colorado Springs, CO C1 [Cortes-Briones, Jose A.; Cahill, John Daniel; Skosnik, Patrick David; Williams, Ashley; Sewell, Richard Andrew; Ranganathan, Mohini; D'Souza, Deepak Cyril] VA Connecticut Healthcare Syst, Psychiat Serv, West Haven, CT USA. [Cortes-Briones, Jose A.; Cahill, John Daniel; Skosnik, Patrick David; Williams, Ashley; Sewell, Richard Andrew; Ranganathan, Mohini; D'Souza, Deepak Cyril] Yale Univ, Dept Psychiat, New Haven, CT 06520 USA. [Mathalon, Daniel H.; Ford, Judith M.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA. [Mathalon, Daniel H.; Roach, Brian J.; Ford, Judith M.] San Francisco VA Med Ctr, Mental Hlth Serv Line, San Francisco, CA USA. RI Skosnik, Patrick/D-6466-2016 NR 0 TC 0 Z9 0 U1 0 U2 1 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0586-7614 EI 1745-1701 J9 SCHIZOPHRENIA BULL JI Schizophr. Bull. PD MAR PY 2015 VL 41 SU 1 MA 2119314 BP S16 EP S16 PG 1 WC Psychiatry SC Psychiatry GA CG8HO UT WOS:000353548200041 ER PT J AU Curcio, N Mervis, JE Bisoglio, J Fiszdon, JM Reddy, F Choi, J AF Curcio, Nicholas Mervis, Joshua E. Bisoglio, Joseph Fiszdon, Joanna M. Reddy, Felice Choi, Jimmy TI ANTICIPATORY PLEASURE AND ITS IMPLICATIONS ON LEARNING IN SCHIZOPHRENIA SO SCHIZOPHRENIA BULLETIN LA English DT Meeting Abstract CT 15th International Congress on Schizophrenia Research (ICOSR) CY MAR 28-APR 01, 2015 CL Colorado Springs, CO C1 [Curcio, Nicholas; Mervis, Joshua E.; Bisoglio, Joseph; Choi, Jimmy] Columbia Univ, Neurocognit Rehabil Res Lab, Med Ctr, New York, NY USA. [Fiszdon, Joanna M.] Yale Univ, Sch Med, VA Connecticut Healthcare Syst, New Haven, CT USA. [Reddy, Felice] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. [Reddy, Felice] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90024 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0586-7614 EI 1745-1701 J9 SCHIZOPHRENIA BULL JI Schizophr. Bull. PD MAR PY 2015 VL 41 SU 1 MA 2118001 BP S166 EP S167 PG 2 WC Psychiatry SC Psychiatry GA CG8HO UT WOS:000353548200438 ER PT J AU Davis, MC Wynn, JK Weiner, K Hellemann, GS Green, MF Marder, SR AF Davis, Michael C. Wynn, J. K. Weiner, Katherine Hellemann, Gerhard S. Green, Michael F. Marder, Stephen R. TI RANDOMIZED CONTROLLED TRIAL OF N-ACETYLCYSTEINE FOR COGNITION AND EEG CORRELATES IN SCHIZOPHRENIA SO SCHIZOPHRENIA BULLETIN LA English DT Meeting Abstract CT 15th International Congress on Schizophrenia Research (ICOSR) CY MAR 28-APR 01, 2015 CL Colorado Springs, CO C1 [Davis, Michael C.] Baylor Coll Med, Psychiat & Behav Sci, Houston, TX 77030 USA. [Wynn, J. K.; Weiner, Katherine; Hellemann, Gerhard S.; Green, Michael F.; Marder, Stephen R.] UCLA Semel Inst, Psychiat & Biobehav Sci, Los Angeles, CA USA. [Wynn, J. K.; Weiner, Katherine; Green, Michael F.; Marder, Stephen R.] VA Greater Los Angeles, Mental Illness Res Educ & Clin Ctr, Los Angeles, CA USA. [Davis, Michael C.] Michael E DeBakey VA Med Ctr, Mental Hlth Care Line, Houston, TX USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0586-7614 EI 1745-1701 J9 SCHIZOPHRENIA BULL JI Schizophr. Bull. PD MAR PY 2015 VL 41 SU 1 MA 2086799 BP S308 EP S309 PG 2 WC Psychiatry SC Psychiatry GA CG8HO UT WOS:000353548200812 ER PT J AU Greenwood, TA Lazzeroni, LC Calkins, ME Freedman, R Green, MF Gur, RE Gur, RC Light, GA Nuechterlein, KH Olincy, A Radant, AD Seidman, LJ Siever, LJ Silverman, JM Stone, WS Sugar, CA Swerdlow, NR Tsuang, DW Tsuang, MT Turetsky, BI Braff, DL AF Greenwood, Tiffany A. Lazzeroni, Laura C. Calkins, Monica E. Freedman, Robert Green, Michael F. Gur, Raquel E. Gur, Ruben C. Light, Gregory A. Nuechterlein, Keith H. Olincy, Ann Radant, Allen D. Seidman, Larry J. Siever, Larry J. Silverman, Jeremy M. Stone, William S. Sugar, Catherine A. Swerdlow, Neal R. Tsuang, Debby W. Tsuang, Ming T. Turetsky, Bruce I. Braff, David L. TI GENETIC ASSESSMENT OF CANDIDATE ENDOPHENOTYPES FROM THE CONSORTIUM ON THE GENETICS OF SCHIZOPHRENIA FAMILY STUDY SO SCHIZOPHRENIA BULLETIN LA English DT Meeting Abstract CT 15th International Congress on Schizophrenia Research (ICOSR) CY MAR 28-APR 01, 2015 CL Colorado Springs, CO C1 [Greenwood, Tiffany A.; Light, Gregory A.; Swerdlow, Neal R.; Tsuang, Ming T.; Braff, David L.] Univ Calif San Diego, Psychiat, La Jolla, CA 92093 USA. [Lazzeroni, Laura C.] Stanford Univ, Psychiat & Behav Sci, Stanford, CA 94305 USA. [Calkins, Monica E.; Gur, Raquel E.; Gur, Ruben C.; Turetsky, Bruce I.] Univ Penn, Psychiat, Philadelphia, PA 19104 USA. [Freedman, Robert; Olincy, Ann] Univ Colorado, Hlth Sci Ctr, Psychiat, Denver, CO USA. [Green, Michael F.; Nuechterlein, Keith H.] Univ Calif Los Angeles, Psychiat & Biobehav Sci, Los Angeles, CA USA. [Green, Michael F.] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. [Light, Gregory A.] VA San Diego Healthcare Syst, VISN Mental Illness Res Educ & Clin Ctr MIRECC 22, San Diego, CA USA. [Radant, Allen D.; Tsuang, Debby W.] Univ Washington, Psychiat & Behav Sci, Seattle, WA 98195 USA. [Radant, Allen D.; Tsuang, Debby W.] VA Puget Sound Hlth Care Syst, Seattle, WA USA. [Seidman, Larry J.; Stone, William S.] Harvard Univ, Sch Med, Psychiat, Boston, MA USA. [Seidman, Larry J.; Stone, William S.] Beth Israel Deaconess Med Ctr, Massachusetts Mental Hlth Ctr, Publ Psychiat Div, Boston, MA 02215 USA. [Siever, Larry J.; Silverman, Jeremy M.] Mt Sinai Sch Med, Psychiat, New York, NY USA. [Siever, Larry J.; Silverman, Jeremy M.] James J Peters VA Med Ctr, New York, NY USA. [Sugar, Catherine A.] Univ Calif Los Angeles, Sch Publ Hlth, Biostat, Los Angeles, CA 90024 USA. [Tsuang, Ming T.] Harvard Inst Psychiat Epidemiol & Genet, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0586-7614 EI 1745-1701 J9 SCHIZOPHRENIA BULL JI Schizophr. Bull. PD MAR PY 2015 VL 41 SU 1 MA 2117107 BP S203 EP S203 PG 1 WC Psychiatry SC Psychiatry GA CG8HO UT WOS:000353548200538 ER PT J AU Haas, GL Honsaker, SM Horton, LE Luther, JF Flounders, MW AF Haas, Gretchen L. Honsaker, Sarah M. Horton, Leslie E. Luther, James F. Flounders, Matthew W. TI DOES GENDER EXERT A MODERATING INFLUENCE ON SOCIAL PERSPECTIVE-TAKING IN SCHIZOPHRENIA? SO SCHIZOPHRENIA BULLETIN LA English DT Meeting Abstract CT 15th International Congress on Schizophrenia Research (ICOSR) CY MAR 28-APR 01, 2015 CL Colorado Springs, CO C1 [Haas, Gretchen L.] Univ Pittsburgh, Psychiat & Psychol, Pittsburgh, PA USA. [Horton, Leslie E.; Flounders, Matthew W.] Univ Pittsburgh, Psychiat, Pittsburgh, PA USA. [Haas, Gretchen L.; Honsaker, Sarah M.; Horton, Leslie E.; Luther, James F.; Flounders, Matthew W.] VA Pittsburgh Healthcare Syst, MIRECC, Pittsburgh, PA USA. [Luther, James F.] Univ Pittsburgh, Epidemiol, Pittsburgh, PA USA. [Honsaker, Sarah M.] Univ Pittsburgh, Psychol, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0586-7614 EI 1745-1701 J9 SCHIZOPHRENIA BULL JI Schizophr. Bull. PD MAR PY 2015 VL 41 SU 1 MA 2117931 BP S77 EP S77 PG 1 WC Psychiatry SC Psychiatry GA CG8HO UT WOS:000353548200206 ER PT J AU Horan, WP Marder, SR Green, M AF Horan, William Powers Marder, Stephen R. Green, Michael TI FURTHER VALIDATION OF A "SECOND GENERATION" CLINICAL ASSESSMENT MEASURE OF NEGATIVE SYMPTOMS SO SCHIZOPHRENIA BULLETIN LA English DT Meeting Abstract CT 15th International Congress on Schizophrenia Research (ICOSR) CY MAR 28-APR 01, 2015 CL Colorado Springs, CO C1 [Horan, William Powers; Marder, Stephen R.; Green, Michael] VA Greater Los Angeles Healthcare Syst, Psychiat, Los Angeles, CA USA. [Horan, William Powers; Marder, Stephen R.; Green, Michael] Univ Calif Los Angeles, Psychiat & Biobehav Sci, Los Angeles, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0586-7614 EI 1745-1701 J9 SCHIZOPHRENIA BULL JI Schizophr. Bull. PD MAR PY 2015 VL 41 SU 1 MA 2096158 BP S108 EP S109 PG 2 WC Psychiatry SC Psychiatry GA CG8HO UT WOS:000353548200291 ER PT J AU Horton, LE Michael, VC Haas, GL AF Horton, Leslie E. Michael, V. C. Haas, Gretchen L. TI EMOTION-BASED DECISION-MAKING IN THOSE AT HIGH RISK FOR SCHIZOPHRENIA SO SCHIZOPHRENIA BULLETIN LA English DT Meeting Abstract CT 15th International Congress on Schizophrenia Research (ICOSR) CY MAR 28-APR 01, 2015 CL Colorado Springs, CO C1 [Horton, Leslie E.; Michael, V. C.; Haas, Gretchen L.] Univ Pittsburgh, Sch Med, Psychiat, Pittsburgh, PA USA. [Haas, Gretchen L.] VA Pittsburgh Hlth Care Syst, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0586-7614 EI 1745-1701 J9 SCHIZOPHRENIA BULL JI Schizophr. Bull. PD MAR PY 2015 VL 41 SU 1 MA 2081626 BP S49 EP S49 PG 1 WC Psychiatry SC Psychiatry GA CG8HO UT WOS:000353548200132 ER PT J AU Jimenez, AM Lee, J Wynn, JK Horan, WP Green, MF AF Jimenez, Amy M. Lee, Junghee Wynn, J. K. Horan, William Powers Green, Michael F. TI SELF-REFERENTIAL MEMORY IN SCHIZOPHRENIA: AN FMRI STUDY SO SCHIZOPHRENIA BULLETIN LA English DT Meeting Abstract CT 15th International Congress on Schizophrenia Research (ICOSR) CY MAR 28-APR 01, 2015 CL Colorado Springs, CO C1 [Jimenez, Amy M.; Lee, Junghee; Wynn, J. K.; Horan, William Powers; Green, Michael F.] Vet Affairs Greater Los Angeles Healthcare Syst, Desert Pacific MIRECC, Los Angeles, CA USA. [Jimenez, Amy M.; Lee, Junghee; Wynn, J. K.; Horan, William Powers; Green, Michael F.] Univ Calif Los Angeles, Psychiat & Biobehav Sci, Los Angeles, CA USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0586-7614 EI 1745-1701 J9 SCHIZOPHRENIA BULL JI Schizophr. Bull. PD MAR PY 2015 VL 41 SU 1 MA 2115433 BP S81 EP S81 PG 1 WC Psychiatry SC Psychiatry GA CG8HO UT WOS:000353548200216 ER PT J AU Kern, RS Zarate, R Glynn, SM Smith, KM Reddy, F Mitchell, SS Turner, LR Iglesias, J Maes, L McNair, A Liberman, RP Kopelowicz, A Green, MF AF Kern, Robert S. Zarate, R. Glynn, Shirley M. Smith, K. M. Reddy, Felice Mitchell, S. S. Turner, Luana R. Iglesias, J. Maes, L. McNair, A. Liberman, R. P. Kopelowicz, A. Green, Michael F. TI THE EFFECTS OF ERRORLESS LEARNING ON WORK OUTCOME IN SCHIZOPHRENIA SO SCHIZOPHRENIA BULLETIN LA English DT Meeting Abstract CT 15th International Congress on Schizophrenia Research (ICOSR) CY MAR 28-APR 01, 2015 CL Colorado Springs, CO C1 [Kern, Robert S.; Zarate, R.; Glynn, Shirley M.; Smith, K. M.; Mitchell, S. S.; Turner, Luana R.; Iglesias, J.; Maes, L.; McNair, A.; Liberman, R. P.; Kopelowicz, A.; Green, Michael F.] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA. [Kern, Robert S.; Glynn, Shirley M.; Reddy, Felice; Green, Michael F.] VA Greater Los Angeles Healthcare Syst, Dept Vet Affairs VISN MIRECC 22, Los Angeles, CA USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0586-7614 EI 1745-1701 J9 SCHIZOPHRENIA BULL JI Schizophr. Bull. PD MAR PY 2015 VL 41 SU 1 MA 2083573 BP S178 EP S178 PG 1 WC Psychiatry SC Psychiatry GA CG8HO UT WOS:000353548200469 ER PT J AU McCleery, A Lee, J Wynn, JK Subotnik, KL Ventura, J Ghermezi, L Hayata, JN Pascual, GN Green, MF Nuechterlein, KH AF McCleery, Amanda Lee, Junghee Wynn, Jonathan K. Subotnik, Kenneth L. Ventura, Joseph Ghermezi, Livon Hayata, Jacqueline N. Pascual, Gabrielle N. Green, Michael F. Nuechterlein, Keith H. TI SOCIAL COGNITION ACROSS PHASE OF ILLNESS IN SCHIZOPHRENIA: AN EXAMINATION OF LOW-LEVEL AND HIGH-LEVEL PROCESSES SO SCHIZOPHRENIA BULLETIN LA English DT Meeting Abstract CT 15th International Congress on Schizophrenia Research (ICOSR) CY MAR 28-APR 01, 2015 CL Colorado Springs, CO C1 [McCleery, Amanda; Lee, Junghee; Wynn, Jonathan K.; Subotnik, Kenneth L.; Ventura, Joseph; Ghermezi, Livon; Hayata, Jacqueline N.; Pascual, Gabrielle N.; Green, Michael F.; Nuechterlein, Keith H.] Univ Calif Los Angeles, Dept Psychiat, Los Angeles, CA USA. [Wynn, Jonathan K.; Green, Michael F.] VA Greater Los Angeles Healthcare Syst, MIRECC, Los Angeles, CA USA. [Nuechterlein, Keith H.] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90024 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0586-7614 EI 1745-1701 J9 SCHIZOPHRENIA BULL JI Schizophr. Bull. PD MAR PY 2015 VL 41 SU 1 BP S55 EP S56 PG 2 WC Psychiatry SC Psychiatry GA CG8HO UT WOS:000353548200149 ER PT J AU Michaels, TM Horan, WP Ginger, EJ Martinovich, Z Pinkham, A Smith, MJ AF Michaels, Tania Marie Horan, William Powers Ginger, E. J. Martinovich, Z. Pinkham, Amy Smith, Matthew James TI COGNITIVE EMPATHY CONTRIBUTES TO POOR SOCIAL FUNCTIONING IN SCHIZOPHRENIA: EVIDENCE FROM A NEW SELF-REPORT MEASURE OF COGNITIVE AND AFFECTIVE EMPATHY SO SCHIZOPHRENIA BULLETIN LA English DT Meeting Abstract CT 15th International Congress on Schizophrenia Research (ICOSR) CY MAR 28-APR 01, 2015 CL Colorado Springs, CO C1 [Michaels, Tania Marie; Ginger, E. J.; Martinovich, Z.; Smith, Matthew James] Northwestern Univ, Dept Psychiat & Behav Sci, Feinberg Sch Med, Chicago, IL 60611 USA. [Horan, William Powers] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA. [Horan, William Powers] VA Greater Los Angeles Healthcare Syst, MIRECC VISN22, Los Angeles, CA USA. [Pinkham, Amy] Univ Texas Dallas, Sch Behav & Brain Sci, Richardson, TX 75083 USA. [Smith, Matthew James] Northwestern Univ, Warren Wright Adolescent Ctr, Feinberg Sch Med, Chicago, IL 60611 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0586-7614 EI 1745-1701 J9 SCHIZOPHRENIA BULL JI Schizophr. Bull. PD MAR PY 2015 VL 41 SU 1 BP S56 EP S56 PG 1 WC Psychiatry SC Psychiatry GA CG8HO UT WOS:000353548200150 ER PT J AU Reddy, F Kern, RS Smith, KM Mitchell, S Glynn, SM Turner, LR Zarate, R Kopelowicz, A Green, MF AF Reddy, Felice Kern, Robert S. Smith, K. M. Mitchell, Sharon Glynn, Shirley M. Turner, Luana R. Zarate, Roberto Kopelowicz, Alex Green, Michael F. TI PREDICTORS OF EMPLOYMENT IN ADULTS WITH SCHIZOPHRENIA: THE IMPORTANCE OF BOTH INTRINSIC AND EXTRINSIC MOTIVATION SO SCHIZOPHRENIA BULLETIN LA English DT Meeting Abstract CT 15th International Congress on Schizophrenia Research (ICOSR) CY MAR 28-APR 01, 2015 CL Colorado Springs, CO C1 [Reddy, Felice; Kern, Robert S.; Glynn, Shirley M.; Green, Michael F.] Greater Los Angeles VA Healthcare Syst, MIRECC, Los Angeles, CA USA. [Reddy, Felice; Kern, Robert S.; Smith, K. M.; Mitchell, Sharon; Glynn, Shirley M.; Turner, Luana R.; Zarate, Roberto; Kopelowicz, Alex; Green, Michael F.] Univ Calif Los Angeles, Dept Psychiat, Los Angeles, CA USA. [Kopelowicz, Alex] San Fernando Valley Mental Hlth Ctr, Van Nuys, CA USA. NR 0 TC 0 Z9 0 U1 2 U2 3 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0586-7614 EI 1745-1701 J9 SCHIZOPHRENIA BULL JI Schizophr. Bull. PD MAR PY 2015 VL 41 SU 1 MA 2119199 BP S187 EP S187 PG 1 WC Psychiatry SC Psychiatry GA CG8HO UT WOS:000353548200495 ER PT J AU Schlosser, D Kim, D Campellone, T Ward, C Vinogradov, S AF Schlosser, Danielle Kim, Daniel Campellone, Tim Ward, Charlie Vinogradov, Sophia TI PRIME: A NEUROSCIENCE-INFORMED MOBILE APP INTERVENTION TO TREAT REWARD PROCESSING IMPAIRMENTS AND IMPROVE QUALITY OF LIFE IN RECENT ONSET SCHIZOPHRENIA SO SCHIZOPHRENIA BULLETIN LA English DT Meeting Abstract CT 15th International Congress on Schizophrenia Research (ICOSR) CY MAR 28-APR 01, 2015 CL Colorado Springs, CO C1 [Schlosser, Danielle; Kim, Daniel; Campellone, Tim; Ward, Charlie; Vinogradov, Sophia] Univ Calif San Francisco, Psychiat, San Francisco, CA 94143 USA. [Vinogradov, Sophia] San Francisco VA Med Ctr, Mental Hlth Serv, San Francisco, CA USA. [Campellone, Tim] Univ Calif Berkeley, Clin Sci, Berkeley, CA 94720 USA. NR 0 TC 1 Z9 1 U1 0 U2 3 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0586-7614 EI 1745-1701 J9 SCHIZOPHRENIA BULL JI Schizophr. Bull. PD MAR PY 2015 VL 41 SU 1 MA 2119338 BP S332 EP S332 PG 1 WC Psychiatry SC Psychiatry GA CG8HO UT WOS:000353548200877 ER PT J AU Siever, LJ AF Siever, Larry J. TI SOCIAL COGNITION IN THE SCHIZOPHRENIA SPECTRUM SO SCHIZOPHRENIA BULLETIN LA English DT Meeting Abstract CT 15th International Congress on Schizophrenia Research (ICOSR) CY MAR 28-APR 01, 2015 CL Colorado Springs, CO C1 [Siever, Larry J.] Icahn Sch Med Mt Sinai, Psychiat, New York, NY 10029 USA. [Siever, Larry J.] James J Peters VAMC, VISN MIRECC 3, Bronx, NY USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0586-7614 EI 1745-1701 J9 SCHIZOPHRENIA BULL JI Schizophr. Bull. PD MAR PY 2015 VL 41 SU 1 MA 2112833 BP S190 EP S190 PG 1 WC Psychiatry SC Psychiatry GA CG8HO UT WOS:000353548200502 ER PT J AU Tabak, NT Horan, WP Bender, A Dolinsky, M Green, MF AF Tabak, Naomi Tuchman Horan, William Powers Bender, A. Dolinsky, M. Green, Michael F. TI MINDFULNESS, EMOTION REGULATION, AND NEGATIVE SYMPTOMS IN SCHIZOPHRENIA SO SCHIZOPHRENIA BULLETIN LA English DT Meeting Abstract CT 15th International Congress on Schizophrenia Research (ICOSR) CY MAR 28-APR 01, 2015 CL Colorado Springs, CO C1 [Tabak, Naomi Tuchman] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90024 USA. [Tabak, Naomi Tuchman; Horan, William Powers; Bender, A.; Dolinsky, M.; Green, Michael F.] VA Greater Angeles Healthcare Syst, Los Angeles, CA USA. [Horan, William Powers; Green, Michael F.] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90024 USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0586-7614 EI 1745-1701 J9 SCHIZOPHRENIA BULL JI Schizophr. Bull. PD MAR PY 2015 VL 41 SU 1 MA 2081514 BP S192 EP S193 PG 2 WC Psychiatry SC Psychiatry GA CG8HO UT WOS:000353548200509 ER PT J AU Walsh-Messinger, J Keller, A Cieslak, K Rotondo, E Goetz, R Gonen, O Malaspina, D AF Walsh-Messinger, Julie Keller, Andreas Cieslak, Kristina Rotondo, Elena Goetz, Raymond Gonen, Oded Malaspina, Dolores TI INFLAMMATION IN THE ANTERIOR CINGULATE CORTEX (ACC) AND ASSOCIATIONS WITH OLFACTORY HEDONICS AND ANHEDONIA IN SCHIZOPHRENIA SO SCHIZOPHRENIA BULLETIN LA English DT Meeting Abstract CT 15th International Congress on Schizophrenia Research (ICOSR) CY MAR 28-APR 01, 2015 CL Colorado Springs, CO C1 [Walsh-Messinger, Julie] Icahn Sch Med Mt Sinai, Psychiat, New York, NY 10029 USA. [Walsh-Messinger, Julie] James J Peters VA Med Ctr, Mental Illness Educ Res & Clin Ctr, Bronx, NY USA. [Keller, Andreas; Cieslak, Kristina; Rotondo, Elena; Goetz, Raymond; Malaspina, Dolores] NYU, Sch Med, Inst Social & Psychiat Initiat InSPIRES, Psychiat, New York, NY USA. [Keller, Andreas] Rockefeller Univ, New York, NY 10021 USA. [Goetz, Raymond] Columbia Univ, Psychiat, New York, NY USA. [Gonen, Oded] NYU, Sch Med, Radiol, New York, NY USA. [Malaspina, Dolores] NY State Off Mental Hlth, Creedmor Psychiat Ctr, Queens, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0586-7614 EI 1745-1701 J9 SCHIZOPHRENIA BULL JI Schizophr. Bull. PD MAR PY 2015 VL 41 SU 1 MA 2083528 BP S278 EP S279 PG 2 WC Psychiatry SC Psychiatry GA CG8HO UT WOS:000353548200733 ER PT J AU Wu, WL Adams, CE Stevens, K Chow, K Patterson, PH AF Wu, Wei-Li Adams, C. E. Stevens, Karen Chow, K. Patterson, P. H. TI NICOTINIC CHOLINERGIC MODULATION OF THE FETAL BRAIN RESPONSE TO MATERNAL IMMUNE ACTIVATION SO SCHIZOPHRENIA BULLETIN LA English DT Meeting Abstract CT 15th International Congress on Schizophrenia Research (ICOSR) CY MAR 28-APR 01, 2015 CL Colorado Springs, CO C1 [Wu, Wei-Li; Chow, K.; Patterson, P. H.] CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA. [Adams, C. E.] Denver VA Med Ctr, Denver, CO USA. [Adams, C. E.; Stevens, Karen] Univ Colorado Denver, Dept Psychiat, Aurora, CO USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0586-7614 EI 1745-1701 J9 SCHIZOPHRENIA BULL JI Schizophr. Bull. PD MAR PY 2015 VL 41 SU 1 MA 2077235 BP S216 EP S216 PG 1 WC Psychiatry SC Psychiatry GA CG8HO UT WOS:000353548200573 ER PT J AU Yao, JK Leonard, S Reddy, R AF Yao, Jeffrey K. Leonard, Sherry Reddy, Ravinder TI HOMEOSTATIC IMBALANCE OF PURINE CATABOLISM IN SCHIZOPHRENIA POSTMORTEM BRAIN SO SCHIZOPHRENIA BULLETIN LA English DT Meeting Abstract CT 15th International Congress on Schizophrenia Research (ICOSR) CY MAR 28-APR 01, 2015 CL Colorado Springs, CO C1 [Yao, Jeffrey K.] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. [Yao, Jeffrey K.] VA Pittsburgh Healthcare Syst, MIRECC VISN4, Pittsburgh, PA USA. [Yao, Jeffrey K.; Reddy, Ravinder] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA. [Yao, Jeffrey K.; Reddy, Ravinder] Univ Pittsburgh, Dept Pharmaceut Sci, Pittsburgh, PA USA. [Leonard, Sherry] Univ Colorado, Dept Psychiat, Denver, CO 80202 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0586-7614 EI 1745-1701 J9 SCHIZOPHRENIA BULL JI Schizophr. Bull. PD MAR PY 2015 VL 41 SU 1 MA 2118353 BP S297 EP S298 PG 2 WC Psychiatry SC Psychiatry GA CG8HO UT WOS:000353548200784 ER PT J AU Kendall, RE Gosser, RA Schulz, LT Trapskin, PJ Caponi, B Safdar, N AF Kendall, Ronald E. Gosser, Rena A. Schulz, Lucas T. Trapskin, Philip J. Caponi, Bartho Safdar, Nasia TI Anti-diarrheat medication use in the treatment of Ebola virus-induced diarrhea SO TRAVEL MEDICINE AND INFECTIOUS DISEASE LA English DT Letter DE Ebola; Anti-diarrheals; Supportive care; Viral gastroenteritis ID MANAGEMENT C1 [Kendall, Ronald E.; Gosser, Rena A.; Schulz, Lucas T.; Trapskin, Philip J.] Univ Wisconsin Hosp & Clin, Dept Pharm, Madison, WI 53705 USA. [Caponi, Bartho] Univ Wisconsin, Div Hosp Med, Dept Med, Sch Med & Publ Hlth, Madison, WI 53705 USA. [Safdar, Nasia] William S Middleton Mem Vet Adm Med Ctr, Madison, WI 53705 USA. [Safdar, Nasia] Univ Wisconsin, Div Infect Dis, Dept Med, Sch Med & Publ Hlth, Madison, WI 53705 USA. RP Kendall, RE (reprint author), 600 Highland Ave F6-133, Madison, WI 53792 USA. EM rkendall@uwhealth.org; rgosser@uwhealth.org NR 6 TC 1 Z9 1 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1477-8939 EI 1873-0442 J9 TRAVEL MED INFECT DI JI Travel Med. Infect. Dis. PD MAR-APR PY 2015 VL 13 IS 2 BP 205 EP 206 DI 10.1016/j.tmaid.2015.01.003 PG 2 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA CH0VT UT WOS:000353741200019 PM 25682446 ER PT J AU Pham, A Hariri, S Yusin, J AF Pham, A. Hariri, S. Yusin, J. TI Timing isn't everything: A case of recurrent angio-oedema SO ALLERGOLOGIA ET IMMUNOPATHOLOGIA LA English DT Letter ID CONVERTING ENZYME-INHIBITORS C1 [Pham, A.; Hariri, S.; Yusin, J.] Vet Affairs Greater Los Angeles Healthcare Syst, Los Angeles, CA 90073 USA. RP Pham, A (reprint author), Vet Affairs Greater Los Angeles Healthcare Syst, Los Angeles, CA 90073 USA. EM Andrewqpham@gmail.conn; Sherwinucla@yahoo.com; Joseph.Yusin2@va.gov NR 10 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER DOYMA SL PI BARCELONA PA TRAVESERA DE GARCIA, 17-21, BARCELONA, 08021, SPAIN SN 0301-0546 EI 1578-1267 J9 ALLERGOL IMMUNOPATH JI Allergol. Immunopath. PD MAR-APR PY 2015 VL 43 IS 2 BP 230 EP 231 DI 10.1016/j.aller.2014.02.001 PG 2 WC Allergy; Immunology SC Allergy; Immunology GA CF7OO UT WOS:000352746400022 PM 24948189 ER PT J AU Wang, EA McGinnis, KA Long, JB Akgun, KM Edelman, EJ Rimland, D Wang, KH Justice, AC Fiellin, DA AF Wang, Emily A. McGinnis, Kathleen A. Long, Jessica B. Akguen, Kathleen M. Edelman, E. Jennifer Rimland, David Wang, Karen H. Justice, Amy C. Fiellin, David A. TI Incarceration and Health Outcomes in HIV-Infected Patients: The Impact of Substance Use, Primary Care Engagement, and Antiretroviral Adherence SO AMERICAN JOURNAL ON ADDICTIONS LA English DT Article ID INJECTION-DRUG USERS; ALCOHOL-USE; HIGH-RISK; VETERANS; THERAPY; RELEASE; PRISON; ACCESS; DEATH; MEN AB Background and ObjectivesOne in seven HIV-infected individuals is incarcerated each year. We used data from the Veterans Aging Cohort Study (VACS) to explore the relationship between incarceration and HIV disease outcomes and evaluate potential mediators of this relationship. MethodsHIV disease outcomes included: low CD4 counts (<200 cells/mL), detectable viral RNA loads (>500 copies/mL), and the VACS Index score. We performed a mediation analysis among 1,591 HIV-infected patients to examine whether unhealthy alcohol use, drug use, primary care engagement, or antiretroviral adherence mediated observed associations. ResultsAmong 1,591 HIV-infected patients, 47% reported having a history of incarceration. In multivariate analyses, a history of incarceration was associated with a higher VACS Index score ( 2.47, 95% CI 0.52-4.43). Mediation analysis revealed that recent drug use attenuated the association by 22% ( 1.93, 95% CI -0.06, 3.91) while other proposed mediators did not. Conclusions and Scientific SignificanceImproving access to drug treatment when incarcerated and upon release may be an important target to improving the health of HIV-infected individuals with a history of incarceration. (Am J Addict 2015;24:178-184) C1 [Wang, Emily A.; Long, Jessica B.; Akguen, Kathleen M.; Edelman, E. Jennifer; Wang, Karen H.; Justice, Amy C.; Fiellin, David A.] Yale Univ, Sch Med, New Haven, CT 06510 USA. [Wang, Emily A.; Edelman, E. Jennifer; Justice, Amy C.; Fiellin, David A.] Yale Univ, Sch Publ Hlth, Ctr Interdisciplinary Res AIDS, New Haven, CT 06510 USA. [McGinnis, Kathleen A.] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA. [Akguen, Kathleen M.; Wang, Karen H.; Justice, Amy C.] VA Connecticut Healthcare Syst, West Haven, CT USA. [Rimland, David] Atlanta VA Med Ctr, Atlanta, GA USA. [Rimland, David] Emory Univ, Sch Med, Atlanta, GA USA. RP Wang, EA (reprint author), Yale Univ, Sch Med, Gen Internal Med, Harkness Hall Bldg A,367 Cedar St,Suite 410A, New Haven, CT 06510 USA. EM emily.wang@yale.edu OI Fiellin, David/0000-0002-4006-010X; Justice, Amy/0000-0003-0139-5502 FU National Institute on Drug Abuse [1R03DA031592]; National Institute on Alcohol Abuse and Alcoholism [U01 AA 13566, U10 AA 13566]; National Institute of Aging (NIA) [K23 AG00826]; Robert Wood Johnson Generalist Faculty Scholar Award; NIA; National Institute of Mental Health; VA HSR&D Research Enhancement Award Program (REAP) PRIME Project [REA 08-266]; National Heart Lung Blood Institute [K23 HL103720]; Yale Clinical Center of Investigation's CTSA [UL1 RR024139] FX Funding for this study was provided by National Institute on Drug Abuse (1R03DA031592) to Dr. Wang; the NIDA had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication. VACS is funded by the National Institute on Alcohol Abuse and Alcoholism (U01 AA 13566 and U10 AA 13566), National Institute of Aging (NIA, K23 AG00826), Robert Wood Johnson Generalist Faculty Scholar Award, an Inter-agency Agreement between NIA, National Institute of Mental Health, and VA HSR&D Research Enhancement Award Program (REAP) PRIME Project (REA 08-266). Emily Wang receives salary support from a career development award from the National Heart Lung Blood Institute (K23 HL103720) and the Yale Clinical Center of Investigation's CTSA Grant (UL1 RR024139). NR 34 TC 2 Z9 2 U1 0 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1055-0496 EI 1521-0391 J9 AM J ADDICTION JI Am. J. Addict. PD MAR PY 2015 VL 24 IS 2 BP 178 EP 184 DI 10.1111/ajad.12177 PG 7 WC Substance Abuse SC Substance Abuse GA CF8KI UT WOS:000352807600013 PM 25662297 ER PT J AU Walsh, TJ Shores, MM Fox, AE Moore, KP Forsberg, CW Kinsey, CE Heckbert, SR Zeliadt, S Thompson, ML Smith, NL Matsumoto, AM AF Walsh, T. J. Shores, M. M. Fox, A. E. Moore, K. P. Forsberg, C. W. Kinsey, C. E. Heckbert, S. R. Zeliadt, S. Thompson, M. L. Smith, N. L. Matsumoto, A. M. TI Recent trends in testosterone testing, low testosterone levels, and testosterone treatment among Veterans SO Andrology LA English DT Article DE testosterone; trends; Veterans ID LOW SERUM TESTOSTERONE; LATE-ONSET HYPOGONADISM; CARDIOVASCULAR-DISEASE; ANDROGEN DEFICIENCY; INCREASED MORTALITY; OLDER MEN; PREVALENCE AB Low serum testosterone (T) is common and increasingly prevalent with increased age. Recent studies report an epidemic' of T prescribing and concern about unnecessary T treatment. We investigated the number of men tested for T, the prevalence of low serum T levels, and initiation of T treatment among those with low T levels in men treated at Veterans Affairs (VA) facilities in the Northwest US (VISN 20). We identified male Veterans aged 40-89years and examined yearly proportions of men tested for T, found to have low T levels (total T<280ng/dL, free T<34pg/mL, or bioavailable T<84ng/dL), and subsequently treated with T from 2002 to 2011. We excluded men who had T treatment in the year prior and men with diagnoses of prostate or breast cancer. Treatment initiation was defined as the first prescription for T within a year following a low T test. From 2002 to 2011, the yearly population of eligible men in VISN 20 increased from 129247 to 163572. The proportion of men who had serum T tests increased from 3.2% in 2002 to 5.8% in 2011. Among the tested men, the percentage of men with low T levels increased from 35.0 to 47.3%. However, the proportion of men with low T levels who were given T treatment within a year decreased from 31.0 to 28.0%. Despite large increases in T testing, and detection of men with low T levels, there was a slight decrease in the proportion of men with low T levels who were treated with T. The decrease in T treatment during this time period contrasts with other studies and may be related to higher comorbidity in Veterans and/or VA formulary restrictions on the use of transdermal T formulations. C1 [Walsh, T. J.; Heckbert, S. R.] Univ Washington, Seattle, WA 98195 USA. [Shores, M. M.; Fox, A. E.; Moore, K. P.; Forsberg, C. W.; Kinsey, C. E.; Zeliadt, S.; Thompson, M. L.; Smith, N. L.; Matsumoto, A. M.] VA Puget Sound Hlth Care Syst, Seattle, WA USA. [Thompson, M. L.] Univ Washington, Dept Biostat, Seattle, WA 98195 USA. [Matsumoto, A. M.] VA Puget Sound Hlth Care Syst, Geriatr Res Educ & Clin Ctr, Seattle, WA USA. [Matsumoto, A. M.] Univ Washington, Sch Med, Dept Med, Div Gerontol & Geriatr Med, Seattle, WA 98195 USA. RP Walsh, TJ (reprint author), Univ Washington, Dept Urol, 1959 NE Pacific St, Seattle, WA 98195 USA. EM walsht@uw.edu FU National Institutes of Health-National Institute on Aging FX This study was supported by an R01 Grant, National Institutes of Health-National Institute on Aging. NR 26 TC 7 Z9 7 U1 2 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2047-2919 EI 2047-2927 J9 ANDROLOGY-US JI Andrology PD MAR PY 2015 VL 3 IS 2 BP 287 EP 292 DI 10.1111/andr.12014 PG 6 WC Andrology SC Endocrinology & Metabolism GA CG6HF UT WOS:000353398800019 PM 25684636 ER PT J AU Whirledge, SD Garcia, JM Smith, RG Lamb, DJ AF Whirledge, Shannon D. Garcia, Jose M. Smith, Roy G. Lamb, Dolores J. TI Ghrelin Partially Protects Against Cisplatin-Induced Male Murine Gonadal Toxicity in a GHSR-1a-Dependent Manner SO BIOLOGY OF REPRODUCTION LA English DT Article DE cell death; cisplatin; fertility; ghrelin; spermatogenesis ID HORMONE SECRETAGOGUE RECEPTOR; HUMAN ENDOTHELIAL-CELLS; LONG-TERM TOXICITY; TESTICULAR CANCER; RAT TESTIS; PROSTATE-CANCER; MOUSE TESTIS; DOUBLE-BLIND; LUNG-CANCER; CHEMOTHERAPY AB The chemotherapeutic drug cisplatin causes a number of dose-dependent side effects, including cachexia and testicular damage. Patients receiving a high cumulative dose of cisplatin may develop permanent azoospermia and subsequent infertility. Thus, the development of chemotherapeutic regimens with the optimal postsurvival quality of life (fertility) is of high importance. This study tested the hypothesis that ghrelin administration can prevent or minimize cisplatin-induced testicular damage and cachexia. Ghrelin and its receptor, the growth hormone secretagogue receptor (GHSR-1a), are expressed and function in the testis. Targeted deletion of ghrelin, or its receptor, significantly increases the rate of cell death in the testis, suggesting a protective role. Intraperitoneal administration of vehicle, ghrelin, or cisplatin alone or in combination with ghrelin, in cycles of 9 or 18 days, to adult male C57Bl/6 mice was performed. Body weight was measured daily and testicular and epididymal weight, sperm density and motility, testicular histology, and testicular cell death were analyzed at the time of euthanization. Ghrelin coadministration decreased the severity of cisplatin-induced cachexia and gonadal toxicity. Body, testicular, and epididymal weights significantly increased as testicular cell death decreased with ghrelin coadministration. The widespread damage to the seminiferous epithelium induced by cisplatin administration was less severe in mice simultaneously treated with ghrelin. Furthermore, ghrelin diminished the deleterious effects of cisplatin on testis and body weight homeostasis in wild-type but not Ghsr(-/-) mice, showing that ghrelin's actions are mediated via GHSR. Ghrelin or more stable GHSR agonists potentially offer a novel therapeutic approach to minimize the testicular damage that occurs after gonadotoxin exposure. C1 [Whirledge, Shannon D.; Lamb, Dolores J.] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA. [Lamb, Dolores J.] Baylor Coll Med, Scott Dept Urol, Houston, TX 77030 USA. [Lamb, Dolores J.] Baylor Coll Med, Ctr Reprod Med, Houston, TX 77030 USA. [Garcia, Jose M.] Baylor Coll Med, Michael E DeBakey Vet Affairs Med Ctr, Div Endocrinol Diabet & Metab, Houston, TX 77030 USA. [Smith, Roy G.] Scripps Res Inst, Dept Metab & Aging, Jupiter, FL USA. RP Lamb, DJ (reprint author), Baylor Coll Med, Dept Urol, One Baylor Plaza Rm N730, Houston, TX 77030 USA. EM dlamb@bcm.tmc.edu FU National Institute of Kidney and Digestive Disease, National Institutes of Health (NIH) [T32 DK007763-06]; Department of Veterans Affairs (MREP); NIH [AG019230, HD060870, AG040583]; Department of Veterans Affairs (SCNCDA); Department of Veterans Affairs [MERIT BX000507] FX Supported in part by a grant from the National Institute of Kidney and Digestive Disease, National Institutes of Health (NIH), T32 DK007763-06 to D.J.L. (trainee: S.D.W.), the Department of Veterans Affairs (MREP, SCNCDA, and MERIT BX000507 to J.M.G.), NIH AG019230 (R.G.S.), and NIH HD060870 and AG040583 (J.M.G.). Presented in part at the Endocrine Society's 90th Annual Meeting, June 15-18, 2008, San Francisco, California. NR 69 TC 4 Z9 5 U1 0 U2 1 PU SOC STUDY REPRODUCTION PI MADISON PA 1691 MONROE ST,SUITE # 3, MADISON, WI 53711-2021 USA SN 0006-3363 EI 1529-7268 J9 BIOL REPROD JI Biol. Reprod. PD MAR 1 PY 2015 VL 92 IS 3 AR 76 DI 10.1095/biolreprod.114.123570 PG 11 WC Reproductive Biology SC Reproductive Biology GA CG3XS UT WOS:000353213500006 PM 25631345 ER PT J AU Brennan, JM Al-Hejily, W Dai, D Shaw, RE Trilesskaya, M Rao, SV Brilakis, ES Anstrom, KJ Messenger, JC Peterson, ED Douglas, PS Sketch, MH AF Brennan, J. Matthew Al-Hejily, Wesam Dai, David Shaw, Richard E. Trilesskaya, Marina Rao, Sunil V. Brilakis, Emmanouil S. Anstrom, Kevin J. Messenger, John C. Peterson, Eric D. Douglas, Pamela S. Sketch, Michael H., Jr. TI Three-Year Outcomes Associated With Embolic Protection in Saphenous Vein Graft Intervention Results in 49 325 Senior Patients in the Medicare-Linked National Cardiovascular Data Registry CathPCI Registry SO Circulation-Cardiovascular Interventions LA English DT Article DE embolic protection devices ID AORTOCORONARY BYPASS GRAFTS; BARE-METAL STENTS; DISTAL PROTECTION; PERCUTANEOUS INTERVENTION; TRIAL; LESIONS; LINKING; DEVICES; EVENTS; STILL AB Background-Information is limited on contemporary use and outcomes of embolic protection devices (EPDs) in saphenous vein graft interventions. Methods and Results-We formed a longitudinal cohort (2005-2009; n=49 325) by linking National Cardiovascular Data Registry CathPCI Registry to Medicare claims to examine the association between EPD use and both procedural and long-term outcomes among seniors (65+ years), adjusting for clinical factors using propensity and instrumental variable methodologies. Prespecified high-risk subgroups included acute coronary syndrome and de novo or graft body lesions. EPDs were used in 21.2% of saphenous vein grafts (median age, 75; 23% women) and were more common in acute coronary syndrome (versus non-acute coronary syndrome; 22% versus 19%), de novo (versus restenotic; 22% versus 14%), and graft body lesions (versus aortic and distal anastomosis; 24% versus 20% versus 8%, respectively). EPDs were associated with a slightly higher incidence of procedural complications, including no reflow (3.9% versus 2.8%; P<0.001), vessel dissection (1.3% versus 1.1%; P=0.05), perforation (0.7% versus 0.4%; P=0.001), and periprocedural myocardial infarction (2.8% versus 1.8%; P<0.001). By 3 years, death, myocardial infarction, and repeat revascularization occurred in 25%, 15%, and 30% of cases, respectively. EPD use was associated with a similar adjusted risk of death (propensity score-matched hazard ratio, 0.96; 95% confidence interval, 0.91-1.02), myocardial infarction (propensity score-matched hazard ratio, 1.00; 95% confidence interval, 0.93-1.09), and repeat revascularization (propensity score-matched hazard ratio, 1.02; 95% confidence interval, 0.96-1.08) in the overall cohort and high-risk subgroups. Conclusions-In this contemporary cohort, EPDs were used more commonly among patients with high-risk clinical indications, yet there was no evidence of improved acute-or long-term outcomes. Further prospective studies are needed to support routine EPD use. C1 [Brennan, J. Matthew; Al-Hejily, Wesam; Dai, David; Rao, Sunil V.; Anstrom, Kevin J.; Peterson, Eric D.; Douglas, Pamela S.; Sketch, Michael H., Jr.] Duke Clin Res Inst, Durham, NC USA. [Shaw, Richard E.] Sutter Pacific Heart Ctr, San Francisco, CA USA. [Trilesskaya, Marina] Carolina Pacific Med Ctr, San Francisco, CA USA. [Brilakis, Emmanouil S.] Vet Affairs North Texas Healthcare Syst, Dallas, TX USA. [Brilakis, Emmanouil S.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA. [Messenger, John C.] Denver Vet Affairs Med Ctr, Denver, CO 80220 USA. RP Brennan, JM (reprint author), Duke Univ, Med Ctr, Div Cardiovasc Med, 2400 Pratt St, Durham, NC 27705 USA. EM j.matthew.brennan@dm.duke.edu OI Brilakis, Emmanouil/0000-0001-9416-9701 FU Duke Clinical Research Institute, Durham, NC FX This work was supported internally by the Duke Clinical Research Institute, Durham, NC. NR 28 TC 8 Z9 8 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1941-7640 EI 1941-7632 J9 CIRC-CARDIOVASC INTE JI Circ.-Cardiovasc. Interv. PD MAR PY 2015 VL 8 IS 3 AR e001403 DI 10.1161/CIRCINTERVENTIONS.114.001403 PG 10 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA CG5CY UT WOS:000353309900001 PM 25714391 ER PT J AU Zimmerman, RF Belanger, ES Pfeiffer, CD AF Zimmerman, Robert F. Belanger, Elizabeth S. Pfeiffer, Christopher D. TI Skin Infections in Returned Travelers: an Update SO CURRENT INFECTIOUS DISEASE REPORTS LA English DT Article DE Skin infection; Travel medicine; Cutaneous larva migrans; Cutaneous leishmaniasis; Tungiasis; Myiasis; Antibiotic resistance; Skin and soft tissue infection; Measles; Chikungunya ID CUTANEOUS LARVA MIGRANS; GEOSENTINEL SURVEILLANCE; LEISHMANIASIS; OUTBREAK; COMMUNITY; DIAGNOSIS; MEASLES; MILTEFOSINE; ELIMINATION; TUNGIASIS AB Dermatologic manifestations of travel-related illness are particularly vexing due to the broad differential diagnosis and clinicians' unfamiliarity with uncommonly seen diseases. This paper aims to educate and update the reader on selected infectious diseases in the returned traveler whose disease manifestations are primarily dermatologic. First, the evolving epidemiology of these infections is examined; understanding the geographic distribution of infectious etiologies helps refine and narrow the differential diagnosis. This is followed by a discussion of six important clinical syndromes including cutaneous larva migrans (CLM), cutaneous leishmaniasis, tungiasis, myiasis, antibiotic-resistant skin and soft tissue infection, and selected infections associated with fever and rash (e.g., measles, chikungunya virus infection, dengue fever, rickettsial spotted fevers). Familiarity with these syndromes and a situational awareness of their epidemiology will facilitate a prompt, accurate diagnosis and lead to appropriate treatment and prevention of further disease spread. C1 [Zimmerman, Robert F.; Belanger, Elizabeth S.; Pfeiffer, Christopher D.] Oregon Hlth & Sci Univ, Dept Med, Portland, OR 97201 USA. [Pfeiffer, Christopher D.] Portland VA Med Ctr, Dept Hosp & Specialty Med, Portland, OR 97239 USA. RP Pfeiffer, CD (reprint author), Portland VA Med Ctr, Dept Hosp & Specialty Med, POB 1034 P3-ID, Portland, OR 97239 USA. EM pfeiffec@ohsu.edu FU Oregon Health Authority FX Elizabeth Belanger has no conflicts of interest. Christopher Pfeiffer received funding for other work from Oregon Health Authority. NR 47 TC 2 Z9 2 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1523-3847 EI 1534-3146 J9 CURR INFECT DIS REP JI Curr. Infect. Dis. Rep. PD MAR PY 2015 VL 17 IS 3 AR 10 DI 10.1007/s11908-015-0467-8 PG 6 WC Infectious Diseases SC Infectious Diseases GA CG7VY UT WOS:000353515300003 ER PT J AU Hall, RK Landerman, LR O'Hare, AM Anderson, RA Colon-Emeric, CS AF Hall, Rasheeda K. Landerman, Lawrence R. O'Hare, Ann M. Anderson, Ruth A. Colon-Emeric, Cathleen S. TI Chronic kidney disease and recurrent falls in nursing home residents: A retrospective cohort study SO GERIATRIC NURSING LA English DT Article DE Skilled nursing facility; Renal insufficiency; Frail elderly ID GLOMERULAR-FILTRATION-RATE; RISK-FACTORS; RENAL-INSUFFICIENCY; SERUM CREATININE; COCKCROFT-GAULT; PREVALENCE; PREVENTION; ANEMIA; COMPLICATIONS; EPIDEMIOLOGY AB This study examined whether chronic kidney disease (CKD) is associated with recurrent falls in older adults in nursing homes (NHs). We used data abstracted over a six month period from 510 NH residents with a history of falls. Thirty-five percent of the NH residents had CKD. In adjusted analyses, the incidence of recurrent falls was similar in those with and without CKD [fall rate ratio (FRR) 1.00, 95% confidence interval (Cl) 0.97-1.02]. Orthostatic hypotension (FRR 1.52, 95% Cl 1.12-2.05), history of falls during the prior six month period (FRR 1.25, 95% CI 1.05-1.49), cane or walker use (FRR 1.64, 95% Cl 1.16-2.33), and ambulatory dysfunction (FRR 1.47, 95% Cl 1.23-1.75) were independently associated with increased fall rate. CKD was not an important predictor of falls in this cohort of nursing home residents with prior falls. Instead, traditional fall risk factors were much more strongly associated with recurrent falls. Published by Elsevier Inc. C1 [Hall, Rasheeda K.] Duke Univ, Med Ctr, Div Nephrol, Dept Med, Durham, NC 27710 USA. [Hall, Rasheeda K.; Colon-Emeric, Cathleen S.] Durham VA Geriatr Res Educ & Clin Ctr, Durham, NC 27705 USA. [Landerman, Lawrence R.; Colon-Emeric, Cathleen S.] Duke Univ, Med Ctr, Div Geriatr, Dept Med, Durham, NC 27710 USA. [Landerman, Lawrence R.; Anderson, Ruth A.] Duke Univ, Sch Nursing, Durham, NC 27710 USA. [O'Hare, Ann M.] VA Puget Sound Healthcare Syst, Dept Med, Seattle, WA 98108 USA. [O'Hare, Ann M.] HSR&D Ctr Excellence, Seattle, WA 98108 USA. [O'Hare, Ann M.] Univ Washington, Div Nephrol, Dept Med, Seattle, WA 98195 USA. RP Hall, RK (reprint author), Box DUMC 2747,2424 Erwin Rd Suite 605, Durham, NC 27710 USA. EM rasheeda.stephens@dm.duke.edu OI Hall, Rasheeda/0000-0002-3057-4828 FU National Institute on Aging of the National Institutes of Health [P30AG028716]; National Institute of Nursing Research [R01NR003178]; Office of Academic Affiliations, US Department of Veterans Affairs FX Research reported in this publication was supported by the National Institute on Aging of the National Institutes of Health under Award Number P30AG028716. It was also supported by the National Institute of Nursing Research (R01NR003178). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.; Dr. Hall was supported in part by a fellowship award from the Office of Academic Affiliations, US Department of Veterans Affairs. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Department of Veterans Affairs or the United States government. NR 29 TC 1 Z9 1 U1 1 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0197-4572 EI 1528-3984 J9 GERIATR NURS JI Geriatr. Nurs. PD MAR-APR PY 2015 VL 36 IS 2 BP 136 EP 141 DI 10.1016/j.gerinurse.2014.12.012 PG 6 WC Geriatrics & Gerontology; Gerontology; Nursing SC Geriatrics & Gerontology; Nursing GA CG3LU UT WOS:000353182500008 PM 25616732 ER PT J AU Gilmore-Bykovskyi, AL AF Gilmore-Bykovskyi, Andrea L. TI Caregiver person-centeredness and behavioral symptoms during mealtime interactions: Development and feasibility of a coding scheme SO GERIATRIC NURSING LA English DT Article DE Dementia; Behavioral Symptoms; Person-Centered Caregiving; Video-observation ID NURSING-HOME RESIDENTS; CLUSTER-RANDOMIZED-TRIAL; HIGH AGREEMENT; OLDER-ADULTS; DEMENTIA-CARE; LOW KAPPA; INTERVENTIONS; DIFFICULTIES; AGITATION; RELIABILITY AB Mealtime behavioral symptoms are distressing and frequently interrupt eating for the individual experiencing them and others in the environment. A computer-assisted coding scheme was developed to measure caregiver person-centeredness and behavioral symptoms for nursing home residents with dementia during mealtime interactions. The purpose of this pilot study was to determine the feasibility, ease of use, and inter-observer reliability of the coding scheme, and to explore the clinical utility of the coding scheme. Trained observers coded 22 observations. Data collection procedures were acceptable to participants. Overall, the coding scheme proved to be feasible, easy to execute and yielded good to very good inter-observer agreement following observer re-training. The coding scheme captured clinically relevant, modifiable antecedents to mealtime behavioral symptoms, but would be enhanced by the inclusion of measures for resident engagement and consolidation of items for measuring caregiver person-centeredness that co-occurred and were difficult for observers to distinguish. (C) 2015 Elsevier Inc. All rights reserved. C1 [Gilmore-Bykovskyi, Andrea L.] US Dept Vet Affairs, GRECC, William S Middleton Hosp, Madison, WI 53705 USA. [Gilmore-Bykovskyi, Andrea L.] Univ Wisconsin, Sch Nursing, Madison, WI 53705 USA. RP Gilmore-Bykovskyi, AL (reprint author), US Dept Vet Affairs, GRECC, William S Middleton Hosp, Madison, WI 53705 USA. EM algilmore@wisc.edu FU National Hartford Centers of Gerontological Nursing Excellence Patricia G. Archbold Scholar Program; Claire M. Fagin Postdoctoral Fellowship Program; Virginia Stone Research Grant in Clinical Gerontology from the American Nurses Foundation; Nurses Foundation of Wisconsin; University of Wisconsin-Madison School of Nursing Eckburg Research Award; National Center for Research Resources, National Institutes of Health [1UL1RR025011] FX This work was supported by the National Hartford Centers of Gerontological Nursing Excellence Patricia G. Archbold Scholar Program and Claire M. Fagin Postdoctoral Fellowship Program. This research was supported by the Virginia Stone Research Grant in Clinical Gerontology from the American Nurses Foundation, and in part by the Nurses Foundation of Wisconsin and University of Wisconsin-Madison School of Nursing Eckburg Research Award. Dr. Gilmore-Bykovskyi's time during preparation of this manuscript was also supported by the William S. Middleton Veterans Affairs Hospital in Madison, WI. This work is also supported, in part, by the Clinical and Translational Science Award program of the National Center for Research Resources, National Institutes of Health (1UL1RR025011). The content is solely the responsibility of the author and does not necessarily represent the official views of the NIH. The author would like to acknowledge Drs. Louis Medvene and Carissa Coleman for early consultation in planning this research. This work was presented at the Gerontological Society of America's 2014 Annual Scientific Meeting in Washington, D.C. NR 30 TC 0 Z9 0 U1 5 U2 10 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0197-4572 EI 1528-3984 J9 GERIATR NURS JI Geriatr. Nurs. PD MAR-APR PY 2015 VL 36 IS 2 SU S BP S10 EP S15 DI 10.1016/j.gerinurse.2015.02.018 PG 6 WC Geriatrics & Gerontology; Gerontology; Nursing SC Geriatrics & Gerontology; Nursing GA CG3LW UT WOS:000353182700003 PM 25784080 ER PT J AU De Santis, ML Myrick, H Lamis, DA Pelic, CP Rhue, C York, J AF De Santis, Mark L. Myrick, Hugh Lamis, Dorian A. Pelic, Christopher P. Rhue, Collete York, Janet TI Suicide-specific Safety in the Inpatient Psychiatric Unit SO Issues in Mental Health Nursing LA English DT Article ID TOWER-OF-BABEL; MENTAL-HEALTH; COLLABORATIVE ASSESSMENT; RISK-ASSESSMENT; EMERGENCY-DEPARTMENT; REVISED NOMENCLATURE; VA PATIENTS; PREVENTION; MANAGEMENT; VETERANS AB In total, 75% of suicides reported to the Joint Commission as sentinel events since 1995, have occurred in psychiatric settings. Ensuring patient safety is one of the primary tasks of inpatient psychiatric units. A review of inpatient suicide-specific safety components, inclusive of incidence and risk; guidelines for evidence-based care; environmental safety; suicide risk assessment; milieu observation and monitoring; psychotherapeutic interventions; and documentation is provided. The Veterans Health Administration (VA) has been recognized as an exemplar system in suicide prevention. A VA inpatient psychiatric unit is used to illustrate the operationalization of a culture of suicide-specific safety. We conclude by describing preliminary unit outcomes and acknowledging limitations of suicide-specific inpatient care and gaps in the current inpatient practices and research on psychotherapeutic interventions, observation, and monitoring. C1 [De Santis, Mark L.; Pelic, Christopher P.; Rhue, Collete; York, Janet] Ralph H Johnson VAMC, Mental Hlth Serv Line, Charleston, SC USA. [Myrick, Hugh] Med Univ S Carolina, Psychiat & Behav Sci, Charleston, SC 29425 USA. [Lamis, Dorian A.] Emory Univ, Sch Med, Atlanta, GA 30303 USA. RP Lamis, DA (reprint author), Emory Univ, Sch Med, 80 Jesse Hill Jr Dr, Atlanta, GA 30303 USA. EM Dalamis@gmail.com OI De Santis, Mark/0000-0002-3611-1779 NR 91 TC 4 Z9 4 U1 4 U2 10 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0161-2840 EI 1096-4673 J9 ISSUES MENT HEALTH N JI Issues Ment. Health Nurs. PD MAR PY 2015 VL 36 IS 3 BP 190 EP 199 DI 10.3109/01612840.2014.961625 PG 10 WC Nursing; Psychiatry SC Nursing; Psychiatry GA CG4ZO UT WOS:000353298300005 PM 25898018 ER PT J AU Fujiwara, K Inoue, T Yorifuji, N Iguchi, M Sakanaka, T Narabayashi, K Kakimoto, K Nouda, S Okada, T Ishida, K Abe, Y Masuda, D Takeuchi, T Fukunishi, S Umegaki, E Akiba, Y Kaunitz, JD Higuchi, K AF Fujiwara, Kaori Inoue, Takuya Yorifuji, Naoki Iguchi, Munetaka Sakanaka, Taisuke Narabayashi, Ken Kakimoto, Kazuki Nouda, Sadaharu Okada, Toshihiko Ishida, Kumi Abe, Yosuke Masuda, Daisuke Takeuchi, Toshihisa Fukunishi, Shinya Umegaki, Eiji Akiba, Yasutada Kaunitz, Jonathan D. Higuchi, Kazuhide TI Combined treatment with dipeptidyl peptidase 4 (DPP4) inhibitor sitagliptin and elemental diets reduced indomethacin-induced intestinal injury in rats via the increase of mucosal glucagon-like peptide-2 concentration SO JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION LA English DT Article DE GLP-1; GLP-2; DPP4; DPP8; sitagliptin ID INFLAMMATORY-BOWEL-DISEASE; LOW-DOSE ASPIRIN; CROHNS-DISEASE; BICARBONATE SECRETION; EXPERIMENTAL COLITIS; IV; MICE; TEDUGLUTIDE; EXPRESSION; IMPACT AB The gut incretin glucagon-like peptide-1 (GLP-1) and the intestinotropic hormone GLP-2 are released from enteroendocrine L cells in response to ingested nutrients. Treatment with an exogenous GLP-2 analogue increases intestinal villous mass and prevents intestinal injury. Since GLP-2 is rapidly degraded by dipeptidyl peptidase 4 (DPP4), DPP4 inhibition may be an effective treatment for intestinal ulcers. We measured mRNA expression and DPP enzymatic activity in intestinal segments. Mucosa! DPP activity and GLP concentrations were measured after administration of the DPP4 inhibitor sitagliptin (STG). Small intestinal ulcers were induced by indomethacin (IM) injection. STG was given before IM treatment, or orally administered after IM treatment with or without an elemental diet (ED). DPP4 mRNA expression and enzymatic activity were high in the jejunum and ileum. STG dose-dependently suppressed ileal mucosal enzyme activity. Treatment with STG prior to IM reduced small intestinal ulcer scores. Combined treatment with STG and ED accelerated intestinal ulcer healing, accompanied by increased mucosa! GLP-2 concentrations. The reduction of ulcers by ED and STG was reversed by co-administration of the GLP-2 receptor antagonist. DPP4 inhibition combined with luminal nutrients, which up-regulate mucosal concentrations of GLP-2, may be an effective therapy for the treatment of small intestinal ulcers. C1 [Fujiwara, Kaori; Inoue, Takuya; Yorifuji, Naoki; Iguchi, Munetaka; Sakanaka, Taisuke; Narabayashi, Ken; Kakimoto, Kazuki; Nouda, Sadaharu; Okada, Toshihiko; Ishida, Kumi; Abe, Yosuke; Masuda, Daisuke; Takeuchi, Toshihisa; Fukunishi, Shinya; Umegaki, Eiji; Higuchi, Kazuhide] Osaka Med Coll, Dept Internal Med 2, Takatsuki, Osaka 5698686, Japan. [Akiba, Yasutada; Kaunitz, Jonathan D.] Greater Los Angeles Vet Affairs Healthcare Syst, Los Angeles, CA USA. [Akiba, Yasutada; Kaunitz, Jonathan D.] Univ Calif Los Angeles, Sch Med, Dept Med, Los Angeles, CA 90024 USA. [Kaunitz, Jonathan D.] Univ Calif Los Angeles, Sch Med, Dept Surg, Los Angeles, CA 90024 USA. RP Inoue, T (reprint author), Osaka Med Coll, Dept Internal Med 2, 2-7 Daigakumachi, Takatsuki, Osaka 5698686, Japan. EM ureuretakuwan@yahoo.co.jp FU NIDDK NIH HHS [R01 DK054221] NR 34 TC 4 Z9 5 U1 0 U2 3 PU JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION PI KYOTO PA KYOTO PREFECTURAL UNIV MED, GRAD SCH MEDICAL SCIENCE, DEPT MOLECULAR GASTROENTEROLOGY & HEPATOLOGY, KYOTO, 602-8566, JAPAN SN 0912-0009 EI 1880-5086 J9 J CLIN BIOCHEM NUTR JI J. Clin. Biochem. Nutr. PD MAR 1 PY 2015 VL 56 IS 2 BP 155 EP 162 DI 10.3164/jcbn.14-111 PG 8 WC Nutrition & Dietetics SC Nutrition & Dietetics GA CG6TE UT WOS:000353434500011 PM 25759522 ER PT J AU Nazi, KM Turvey, CL Klein, DM Hogan, TP Woods, SS AF Nazi, Kim M. Turvey, Carolyn L. Klein, Dawn M. Hogan, Timothy P. Woods, Susan S. TI VA OpenNotes: exploring the experiences of early patient adopters with access to clinical notes SO JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION LA English DT Article DE access; patient portal; eHealth; Open Notes; communication; veteran ID PERSONAL HEALTH RECORDS; PATIENTS ONLINE ACCESS; MEDICAL-RECORDS; MEANINGFUL USE; OF-VETERANS; CARE; INFORMATION; PORTALS; DOCTORS; TRANSFORMATION AB Objective To explore the experience of early patient adopters who accessed their clinical notes online using the Blue Button feature of the My HealtheVet portal. Methods A web-based survey of VA patient portal users from June 22 to September 15, 2013. Results 33.5% of respondents knew that clinical notes could be viewed, and nearly one in four (23.5%) said that they had viewed their notes at least once. The majority of VA Notes users agreed that accessing their notes will help them to do a better job of taking medications as prescribed (80.1%) and be better prepared for clinic visits (88.6%). Nine out of 10 users agreed that use of visit notes will help them understand their conditions better (91.8%), and better remember the plan for their care (91.9%). In contrast, 87% disagreed that VA Notes will make them worry more, and 88.4% disagreed that access to VA Notes will be more confusing than helpful. Users who had either contacted their provider or healthcare team (11.9%) or planned to (13.5%) primarily wanted to learn more about a health issue, medication, or test results (53.7%). Conclusions Initial assessment of the patient experience within the first 9 months of availability provides evidence that patients both value and benefit from online access to clinical notes. These findings are congruent with OpenNotes study findings on a broader scale. Additional outreach and education is needed to enhance patient awareness. Healthcare professionals should author notes keeping in mind the opportunity patient access presents for enhanced communication. C1 [Nazi, Kim M.] US Dept Vet Affairs, Vet & Consumers Hlth Informat Off, Off Informat & Analyt, Vet Hlth Adm, Washington, DC USA. [Turvey, Carolyn L.; Klein, Dawn M.] Iowa City VA Hlth Care Syst, Comprehens Access & Delivery Res & Evaluat CADRE, Iowa City, IA USA. [Turvey, Carolyn L.; Klein, Dawn M.] Univ Iowa, Dept Psychiat, Carver Coll Med, Iowa City, IA 52242 USA. [Hogan, Timothy P.] Edith Nourse Rogers Mem Vet Hosp, CHOIR, A VA HSR&D Ctr Innovat, Bedford, MA USA. [Hogan, Timothy P.] eHlth Qual Enhancement Res Initiat, Natl eHlth QUERI Coordinating Ctr, Edith Nourse Rogers Mem Vet Hosp, Bedford, MA USA. [Hogan, Timothy P.] Univ Massachusetts, Sch Med, Dept Quantitat Hlth Sci, Div Hlth Informat & Implementat Sci, Worcester, MA USA. [Woods, Susan S.] VA Maine Healthcare Syst, Togus, ME USA. [Woods, Susan S.] Oregon Hlth & Sci Univ, Dept Med Informat & Clin Epidemiol, Portland, OR 97201 USA. RP Nazi, KM (reprint author), Vet & Consumers Hlth Informat Off, C-O 113 Holland Ave, Albany, NY 12208 USA. EM kim.nazi@va.gov FU Veterans Health Administration FX Primary funding source: Veterans Health Administration. NR 47 TC 17 Z9 17 U1 3 U2 4 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1067-5027 EI 1527-974X J9 J AM MED INFORM ASSN JI J. Am. Med. Inf. Assoc. PD MAR PY 2015 VL 22 IS 2 BP 380 EP 389 DI 10.1136/amiajnl-2014-003144 PG 10 WC Computer Science, Information Systems; Computer Science, Interdisciplinary Applications; Health Care Sciences & Services; Information Science & Library Science; Medical Informatics SC Computer Science; Health Care Sciences & Services; Information Science & Library Science; Medical Informatics GA CF7YE UT WOS:000352771500015 PM 25352570 ER PT J AU Shah, AD Schmidt, H Sen, S Shlipak, MG Kanaya, AM AF Shah, Arti D. Schmidt, Heidi Sen, Saunak Shlipak, Michael G. Kanaya, Alka M. TI The association between body composition and cystatin C in South Asians: Results from the MASALA study SO OBESITY RESEARCH & CLINICAL PRACTICE LA English DT Article DE Body composition; Ectopic fat; Cystatin C; South Asian ID CHRONIC KIDNEY-DISEASE; GLOMERULAR-FILTRATION-RATE; ADIPOSE-TISSUE; SUBCUTANEOUS ADIPOSITY; DIABETES-MELLITUS; ATHEROSCLEROSIS; AMERICA; OBESITY; COHORT AB While South Asians have high rates of obesity and kidney disease, little is known about the effect of regional body composition on kidney function. We investigated the association between body composition measures and cystatin C-based estimated glomerular filtration rate (eGFR(cysC)) in 150 immigrant South Asians. The inverse association between overall adiposity and eGFR(cysC) was attenuated by C-reactive protein (CRP), while the association of ectopic fat was completely attenuated by metabolic covariates and CRP. In immigrant South Asians, the associations between overall adiposity and ectopic fat with decreased kidney function are largely explained by metabolic alterations and inflammation. (C) 2014 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved. C1 [Shah, Arti D.] Univ Calif San Francisco, Div Endocrinol & Metab, San Francisco, CA 94143 USA. [Schmidt, Heidi; Kanaya, Alka M.] Univ Calif San Francisco, Dept Med, Div Gen Internal Med, San Francisco, CA USA. [Sen, Saunak; Shlipak, Michael G.; Kanaya, Alka M.] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA. [Shlipak, Michael G.] San Francisco VA Med Ctr, Div Gen Internal Med, San Francisco, CA USA. RP Kanaya, AM (reprint author), 2200 Post St,Suite C-428,POB 1222, San Francisco, CA 94115 USA. EM Arti.Shah@ucsf.edu FU NIH [K23 HL080026-01]; NIH/NCRR UCSF-CTSI Grant [UL1 RR024131]; T32 Training Grant [5T32DK007418]; Wilsey Family Foundation; [K24HL112827]; [RO1HL093009] FX This MASALA study was supported by the NIH [grant no. K23 HL080026-01] and by NIH/NCRR UCSF-CTSI Grant Number UL1 RR024131. Dr. Shah was supported by the T32 Training Grant Number 5T32DK007418 and the Wilsey Family Foundation. Dr. Kanaya was supported by K24HL112827 and RO1HL093009. NR 16 TC 2 Z9 2 U1 0 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1871-403X EI 1878-0318 J9 OBES RES CLIN PRACT JI Obes. Res. Clin. Pract. PD MAR-APR PY 2015 VL 9 IS 2 BP 180 EP 183 DI 10.1016/j.orcp.2014.10.221 PG 4 WC Endocrinology & Metabolism; Nutrition & Dietetics SC Endocrinology & Metabolism; Nutrition & Dietetics GA CG1XJ UT WOS:000353068500010 PM 25465493 ER PT J AU Shields, RK Nguyen, MH Potoski, BA Press, EG Chen, L Kreiswirth, BN Clarke, LG Eschenauer, GA Clancy, CJ AF Shields, Ryan K. Nguyen, M. Hong Potoski, Brian A. Press, Ellen G. Chen, Liang Kreiswirth, Barry N. Clarke, Lloyd G. Eschenauer, Gregory A. Clancy, Cornelius J. TI Doripenem MICs and ompK36 Porin Genotypes of Sequence Type 258, KPC-Producing Klebsiella pneumoniae May Predict Responses to Carbapenem-Colistin Combination Therapy among Patients with Bacteremia SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID CRITICALLY-ILL PATIENTS; RESISTANT; ENTEROBACTERIACEAE; MORTALITY AB Treatment failures of a carbapenem-colistin regimen among patients with bacteremia due to sequence type 258 (ST258), KPC-2-producing Klebsiella pneumoniae were significantly more likely if both agents were inactive in vitro, as defined by a colistin MIC of >2 mu g/ml and the presence of either a major ompK36 porin mutation (guanine and alanine insertions at amino acids 134 and 135 [ins aa 134-135 GD], IS5 promoter insertion [P = 0.007]) or a doripenem MIC of >8 mu g/ml (P = 0.01). Major ompK36 mutations among KPC-K. pneumoniae strains are important determinants of carbapenem-colistin responses in vitro and in vivo. C1 [Shields, Ryan K.; Nguyen, M. Hong; Press, Ellen G.; Clancy, Cornelius J.] Univ Pittsburgh, Dept Med, Pittsburgh, PA USA. [Shields, Ryan K.; Nguyen, M. Hong; Potoski, Brian A.; Clarke, Lloyd G.; Eschenauer, Gregory A.] Univ Pittsburgh, Med Ctr, Antibiot Management Program, Pittsburgh, PA USA. [Shields, Ryan K.; Nguyen, M. Hong; Clancy, Cornelius J.] Univ Pittsburgh, Med Ctr, XDR Pathogen Lab, Pittsburgh, PA USA. [Chen, Liang; Kreiswirth, Barry N.] Rutgers State Univ, New Jersey Med Sch, Publ Hlth Res Inst, Newark, NJ 07102 USA. [Eschenauer, Gregory A.] Univ Pittsburgh, Med Ctr, Dept Pharm, Pittsburgh, PA USA. [Potoski, Brian A.] Univ Pittsburgh, Dept Pharm & Therapeut, Pittsburgh, PA USA. [Clancy, Cornelius J.] VA Pittsburgh Hlth Syst, Pittsburgh, PA USA. RP Nguyen, MH (reprint author), Univ Pittsburgh, Dept Med, Pittsburgh, PA USA. EM mhn5@pitt.edu FU University of Pittsburgh Medical Center; National Center for Advanced Translational Sciences of the National Institutes of Health (NIH) [KL2 RR024154] FX This project was supported by funding provided to the XDR Pathogen Laboratory by the University of Pittsburgh Medical Center and by the National Center for Advanced Translational Sciences of the National Institutes of Health (NIH) under award no. KL2 RR024154 given to R.K.S. NR 15 TC 10 Z9 10 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD MAR PY 2015 VL 59 IS 3 BP 1505 EP 1509 DI 10.1128/AAC.03894-14 PG 5 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA CF4VF UT WOS:000352550000016 PM 25534733 ER PT J AU Cortese, BM Uhde, TW LaRowe, SD Stein, SV Freeman, WC McClernon, FJ Brady, KT Hartwell, KJ AF Cortese, Bernadette M. Uhde, Thomas W. LaRowe, Steven D. Stein, Sarah V. Freeman, W. Connor McClernon, F. Joseph Brady, Kathleen T. Hartwell, Karen J. TI Olfactory Cue Reactivity in Nicotine-Dependent Adult Smokers SO PSYCHOLOGY OF ADDICTIVE BEHAVIORS LA English DT Article DE smoking; odor cues; craving; tobacco dependence; cue reactivity ID IN-VIVO; SMOKING-CESSATION; ALCOHOLICS; GENDER; INDUCTION; DRINKERS; STIMULI; PLACEBO; TRIAL; SMELL AB Cue-elicited reactivity is a significant factor in relapse during smoking quit attempts. Previous research has focused primarily on visual smoking cues, with very limited research examining reactivity to olfactory triggers. Twenty-six adult non-treatment-seeking, nicotine-dependent smokers were exposed to 7 odorants during a cue-reactivity session measuring heart rate, skin conductance, and subjective craving. Cues included 2 cigarette odors (fresh tobacco and cigarette smoke), 2 odors previously identified as smoking-related (freshly mowed grass and coffee), 2 odors previously identified as unrelated to smoking (lavender and burned rubber), and 1 odorless control (propylene glycol). Pairwise comparisons demonstrated that subjective intensity of craving was significantly higher following exposure to the fresh tobacco odor compared with the odorless control (p < .01). A significant main effect for cue type on a physiological measure of arousal was also revealed, with a fresh tobacco odor-elicited significant increase in skin conductance level compared with the odorless control. However, no main effect of cue type on heart rate was found (p = .25). The results of the present study indicate that cigarette odor is an effective olfactory cue that heightens both subjective craving and increases skin conductance in smokers. Future research is needed to evaluate whether avoidance of these odors, or extinction of responses to them, can reduce relapse risk during smoking quit attempts. C1 [Cortese, Bernadette M.; Uhde, Thomas W.; LaRowe, Steven D.; Stein, Sarah V.; Freeman, W. Connor; Brady, Kathleen T.; Hartwell, Karen J.] Med Univ S Carolina, Dept Psychiat & Behav Sci, Charleston, SC 29425 USA. [LaRowe, Steven D.; Brady, Kathleen T.; Hartwell, Karen J.] Ralph H Johnson VAMC, Charleston, SC USA. [McClernon, F. Joseph] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27706 USA. RP Cortese, BM (reprint author), Med Univ S Carolina, Dept Psychiat & Behav Sci, MSC 861, Charleston, SC 29425 USA. EM corteseb@musc.edu OI LaRowe, Steven/0000-0002-7664-2451 FU Medical University of South Carolina's South Carolina Clinical and Translational Research Institute (SCTR) [UL1 RR029882]; NIMH [K01MH090548] FX This research was supported by the Medical University of South Carolina's South Carolina Clinical and Translational Research Institute (SCTR) Grant UL1 RR029882 (Karen J. Hartwell) and by NIMH Grant K01MH090548 (Bernadette M. Cortese). We thank Max Owens and Todd LeMatty for their assistance during data acquisition and the preparation of this article. We also thank ScentAir Corporation, Charlotte, NC for providing the odorants. NR 34 TC 3 Z9 3 U1 0 U2 3 PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA SN 0893-164X EI 1939-1501 J9 PSYCHOL ADDICT BEHAV JI Psychol. Addict. Behav. PD MAR PY 2015 VL 29 IS 1 BP 91 EP 96 DI 10.1037/adb0000018 PG 6 WC Substance Abuse; Psychology, Multidisciplinary SC Substance Abuse; Psychology GA CF1PD UT WOS:000352318200011 PM 25180553 ER PT J AU Maughan, BC Seigel, TA Napoli, AM AF Maughan, Brandon C. Seigel, Todd A. Napoli, Anthony M. TI PLETH VARIABILITY INDEX AND FLUID RESPONSIVENESS OF HEMODYNAMICALLY STABLE PATIENTS AFTER CARDIOTHORACIC SURGERY SO AMERICAN JOURNAL OF CRITICAL CARE LA English DT Article ID CARDIOPULMONARY BYPASS; CARDIAC-SURGERY; PREDICTION AB Background Fluid responsiveness is a measure of preload dependence and is defined as an increase in cardiac output due to volume expansion. Recent publications have suggested that variation in amplitude of the pulse oximetry waveform may be predictive of fluid responsiveness. The pleth variability index (PVI) was developed as a noninvasive bedside measurement of this variation in the pulse oximetry waveform. Objectives To measure the discriminatory value of PVI for predicting fluid responsiveness as measured by pulmonary artery catheter thermodilution in patients after cardiothoracic surgery. Methods A prospective observational study of hemodynamically stable postoperative cardiac surgery patients with pulmonary artery catheters. A fingertip sensor was used to measure PVI. Vital signs, PVI, and cardiac index were measured before, during, and after passive leg raise. Fluid responsiveness was defined by increase in cardiac index of greater than 15% during passive leg raise. The discriminatory value of PVI was assessed by using the Wilcoxon method to measure the area under the receiver operating curve. Results In 13 months, 47 patients (24 receiving mechanical ventilation, 23 spontaneously breathing) were enrolled. Fluid responsiveness was noted in 42% of intubated patients and 48% of spontaneously breathing patients. PVI was not adequate to discriminate fluid responsiveness in intubated patients (area under curve, 0.63; P=.16) or spontaneously breathing patients (area under curve, 0.41; P=.75). Conclusions Among postoperative cardiac surgery patients, PVI is not reliable for predicting fluid responsiveness as measured by pulmonary artery catheter thermodilution, regardless of ventilatory status. C1 Brown Univ, Rhode Isl Hosp, Alpert Med Sch, Dept Emergency Med, Providence, RI 02912 USA. [Maughan, Brandon C.] Univ Penn, Vet Affairs Med Ctr, Robert Wood Johnson Clin Scholar Philadelphia, Philadelphia, PA 19104 USA. [Seigel, Todd A.] Kaiser Oakland Med Ctr, Dept Emergency Med & Crit Care, Oakland, CA USA. [Napoli, Anthony M.] Brown Univ, Rhode Isl Hosp, Alpert Med Sch, Providence, RI 02912 USA. RP Maughan, BC (reprint author), Univ Penn, 423 Guardian Ave,Blockley Hall 1303A, Philadelphia, PA 19104 USA. EM Brandon.Maughan@uphs.upenn.edu NR 14 TC 0 Z9 0 U1 2 U2 2 PU AMER ASSOC CRITICAL CARE NURSES PI ALISO VIEJO PA 101 COLUMBIA, ALISO VIEJO, CA 92656 USA SN 1062-3264 EI 1937-710X J9 AM J CRIT CARE JI Am. J. Crit. Care PD MAR 1 PY 2015 VL 24 IS 2 BP 172 EP 175 DI 10.4037/ajcc2015864 PG 4 WC Critical Care Medicine; Nursing SC General & Internal Medicine; Nursing GA CE8XL UT WOS:000352127300011 PM 25727278 ER PT J AU Yanke, E Zellmer, C Van Hoof, S Moriarty, H Carayon, P Safdar, N AF Yanke, Eric Zellmer, Caroline Van Hoof, Sarah Moriarty, Helene Carayon, Pascale Safdar, Nasia TI Understanding the current state of infection prevention to prevent Clostridium difficile infection: A human factors and systems engineering approach SO AMERICAN JOURNAL OF INFECTION CONTROL LA English DT Article DE Clostridium difficile; Contact precautions; Infection control; Human factors; Systems engineering ID HAND HYGIENE COMPLIANCE; HEALTH-CARE WORKERS; CONTACT PRECAUTIONS; PATIENT SAFETY; BURDEN; VISITORS; DIARRHEA AB Background: Achieving and sustaining high levels of health care worker (HCW) compliance with contact isolation precautions is challenging. The aim of this study was to determine HCW work system barriers to and facilitators of adherence to contact isolation for patients with suspected or confirmed Clostridium difficile infection (CDI) using a human factors and systems engineering approach. Methods: This prospective cohort study took place between September 2013 and November 2013 at a large academic medical center (hospital A) and an affiliated Veterans Administration hospital (hospital B). A human factors engineering (HFE) model for patient safety, the Systems Engineering Initiative for Patient Safety model, was used to guide work system analysis and direct observation data collection. There were 288 observations conducted. HCWs and visitors were assessed for compliance with all components of contact isolation precautions (hand hygiene, gowning, and gloving) before and after patient contact. Time required to complete contact isolation precautions was measured, and adequacy of contact isolation supplies was assessed. Results: Full compliance with contact isolation precautions was low at both hospitals A (7%) and B (22%). Lack of appropriate hand hygiene prior to room entry (compliance for hospital A: 18%; compliance for hospital B: 29%) was the most common reason for lack of full compliance. More time was required for full compliance compared with compliance with no components of contact isolation precautions before patient room entry, inside patient room, and after patient room exit (59.9 vs 3.2 seconds, P <. 001; 507.3 vs 149.7 seconds, P = .006; 15.2 vs 1.3 seconds, P <.001, respectively). Compliance was lower when contact isolation supplies were inadequate (4% vs 16%, P = .005). Conclusions: Adherence to contact isolation precautions for CDI is a complex, time-consuming process. HFE analysis indicates that multiple work system components serve as barriers and facilitators to full compliance with contact isolation precautions and should be addressed further to prevent CDI. Published by Elsevier Inc. on behalf of the Association for Professionals in Infection Control and Epidemiology, Inc. C1 [Yanke, Eric] William S Middleton Mem Vet Adm Med Ctr, Dept Med, Madison, WI USA. [Zellmer, Caroline] Univ Wisconsin, Coll Agr & Life Sci, Madison, WI 53706 USA. [Van Hoof, Sarah] Univ Wisconsin Hosp & Clin, Dept Infect Control, Madison, WI 53792 USA. [Moriarty, Helene] Villanova Univ, Coll Nursing, Villanova, PA 19085 USA. [Moriarty, Helene] Philadelphia Vet Affairs Med Ctr, Philadelphia, PA USA. [Carayon, Pascale] Univ Wisconsin, Dept Ind & Syst Engn, Ctr Qual & Prod Improvement, Madison, WI USA. [Safdar, Nasia] William S Middleton Mem Vet Adm Med Ctr, Madison, WI USA. [Safdar, Nasia] Univ Wisconsin, Sch Med, Dept Med, Div Infect Dis, Madison, WI USA. [Safdar, Nasia] Univ Wisconsin, Infect Control Dept, Madison, WI USA. RP Safdar, N (reprint author), UWMF Centennial Bldg,1685 Highland Ave, Madison, WI 53705 USA. EM ns2@medicine.wisc.edu FU Veterans Affairs MERIT award; University of Wisconsin Institute for Clinical and Translational Research; Clinical and Translational Science Award program; National Center for Advancing Translational Sciences [9U54TR000021] FX Dr. Safdar is supported by a Veterans Affairs MERIT award. Dr. Carayon is supported by the University of Wisconsin Institute for Clinical and Translational Research and the Clinical and Translational Science Award program, previously through the National Center for Research Resources (grant no. 1UL1RR025011), and now by the National Center for Advancing Translational Sciences (grant no. 9U54TR000021). NR 23 TC 7 Z9 7 U1 3 U2 11 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-6553 EI 1527-3296 J9 AM J INFECT CONTROL JI Am. J. Infect. Control PD MAR PY 2015 VL 43 IS 3 BP 241 EP 247 DI 10.1016/j.ajic.2014.11.026 PG 7 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA CE8PQ UT WOS:000352106200006 PM 25728149 ER PT J AU Khan, A Rao, A Reyes-Sacin, C Hayakawa, K Szpunar, S Riederer, K Kaye, K Fishbain, JT Levine, D AF Khan, Amber Rao, Amitha Reyes-Sacin, Carlos Hayakawa, Kayoko Szpunar, Susan Riederer, Kathleen Kaye, Keith Fishbain, Joel T. Levine, Diane TI Use of portable electronic devices in a hospital setting and their potential for bacterial colonization SO AMERICAN JOURNAL OF INFECTION CONTROL LA English DT Article DE Mobile electronic devices; Contamination ID MOBILE PHONES; CONTAMINATION; PHYSICIANS AB Portable electronic devices are increasingly being used in the hospital setting. As with other fomites, these devices represent a potential reservoir for the transmission of pathogens. We conducted a convenience sampling of devices in 2 large medical centers to identify bacterial colonization rates and potential risk factors. Copyright (C) 2015 by the Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. C1 [Khan, Amber; Levine, Diane] Detroit Med Ctr, Dept Internal Med, Detroit, MI USA. [Khan, Amber; Kaye, Keith; Levine, Diane] Wayne State Univ, Sch Med, Detroit, MI USA. [Rao, Amitha] Michael E Debakey Vet Adm Med Ctr, Dept Primary Care Med, Houston, TX USA. [Reyes-Sacin, Carlos] Med AIDS Outreach Alabama, Dept Infect Dis, Montgomery, AL USA. [Hayakawa, Kayoko] Natl Ctr Global Hlth & Med, Dis Control & Prevent Ctr, Tokyo, Japan. [Szpunar, Susan; Riederer, Kathleen] St John Hosp & Med Ctr, Dept Grad Med Educ, Detroit, MI USA. [Kaye, Keith] St John Hosp & Med Ctr, Div Infect Dis, Dept Internal Med, Detroit, MI USA. [Fishbain, Joel T.] Detroit Med Ctr, Div Infect Dis, Detroit, MI USA. RP Khan, A (reprint author), Detroit Receiving Hosp & Univ Hlth Ctr, 4201 St Antoine,UHC 2E, Detroit, MI 48201 USA. EM amkha@med.wayne.edu NR 7 TC 3 Z9 3 U1 2 U2 5 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-6553 EI 1527-3296 J9 AM J INFECT CONTROL JI Am. J. Infect. Control PD MAR PY 2015 VL 43 IS 3 BP 286 EP 288 DI 10.1016/j.ajic.2014.11.013 PG 3 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA CE8PQ UT WOS:000352106200015 PM 25557772 ER PT J AU Lee, JH Cho, MH Hersh, CP McDonald, MLN Wells, JM Dransfield, MT Bowler, RP Lynch, DA Lomas, DA Crapo, JD Silverman, EK AF Lee, Jin Hwa Cho, Michael H. Hersh, Craig P. McDonald, Merry-Lynn N. Wells, J. Michael Dransfield, Mark T. Bowler, Russell P. Lynch, David A. Lomas, David A. Crapo, James D. Silverman, Edwin K. CA COPDGene Investigators ECLIPSE Investigators TI IREB2 and GALC Are Associated with Pulmonary Artery Enlargement in Chronic Obstructive Pulmonary Disease SO AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY LA English DT Article DE chronic obstructive pulmonary disease; genome-wide association; pulmonary hypertension; subtyping ID GENOME-WIDE ASSOCIATION; AIR-FLOW OBSTRUCTION; IRON HOMEOSTASIS; LUNG TRANSPLANTATION; CHRONIC-BRONCHITIS; COPD PATIENTS; HYPERTENSION; EMPHYSEMA; SUSCEPTIBILITY; METAANALYSIS AB Pulmonary hypertension is associated with advanced chronic obstructive pulmonary disease (COPD), although pulmonary vascular changes occur early in the course of the disease. Pulmonary artery (PA) enlargement (PAE) measured by computed tomography correlates with pulmonary hypertension and COPD exacerbation frequency. Genome-wide association studies of PAE in subjects with COPD have not been reported. To investigate whether genetic variants are associated with PAE within subjects with COPD, we investigated data from current and former smokers from the COPDGene Study and the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints study. The ratio of the diameter of the PA to the diameter of the aorta (A) was measured using computed tomography. PAE was defined as PA/A greater than 1. A genome-wide association study for COPD with PAE was performed using subjects with COPD without PAE (PA/A <= 1) as a control group. A secondary analysis used smokers with normal spirometry as a control group. Genotyping was performed on Illumina platforms. The results were summarized using fixed-effect meta-analysis. Both meta-analyses revealed a genome-wide significant locus on chromosome 15q25.1 in IREB2 (COPD with versus without PAE, rs7181486; odds ratio [OR] = 1.32; P = 2.10 x 10(-8); versus smoking control subjects, rs2009746; OR = 1.42; P= 1.32 x 10(-9)). PAE was also associated with a region on 14q31.3 near the GALC gene (rs7140285; OR = 1.55; P = 3.75 x 10(-8)). Genetic variants near IREB2 and GALC likely contribute to genetic susceptibility to PAE associated with COPD. This study provides evidence for genetic heterogeneity associated with a clinically important COPD vascular subtype. C1 [Lee, Jin Hwa; Cho, Michael H.; Hersh, Craig P.; McDonald, Merry-Lynn N.; Silverman, Edwin K.] Brigham & Womens Hosp, Channing Div Network Med, Boston, MA 02115 USA. [Cho, Michael H.; Hersh, Craig P.; Silverman, Edwin K.] Brigham & Womens Hosp, Div Pulm & Crit Care Med, Boston, MA 02115 USA. [Lee, Jin Hwa] Ewha Womans Univ, Sch Med, Dept Internal Med, Div Pulm & Crit Care Med, Seoul, South Korea. [Wells, J. Michael; Dransfield, Mark T.] Univ Alabama Birmingham, Lung Hlth Ctr, Div Pulm Allergy & Crit Care, Birmingham, AL USA. [Wells, J. Michael; Dransfield, Mark T.] Birmingham Vet Affairs Med Ctr, Birmingham, AL USA. [Bowler, Russell P.; Lynch, David A.; Crapo, James D.] Natl Jewish Hlth, Div Pulm & Crit Care, Denver, CO USA. [Lomas, David A.] UCL, Wolfson Inst Biomed Res, London, England. RP Silverman, EK (reprint author), Brigham & Womens Hosp, Channing Div Network Med, 181 Longwood Ave, Boston, MA 02115 USA. EM jinhwalee@ewha.ac.kr; ed.silverman@channing.harvard.edu RI Agusti Garcia-Navarro, Alvar/F-4474-2015; Mattheisen, Manuel/B-4949-2012; Coxson, Harvey/A-9861-2017 OI Agusti Garcia-Navarro, Alvar/0000-0003-3271-3788; Mattheisen, Manuel/0000-0002-8442-493X; Coxson, Harvey/0000-0001-5750-9711; MacNee, William/0000-0002-3692-1448; Comellas, Alejandro/0000-0003-1521-7520 FU National Institutes of Health [R01 HL089856, R01 HL075478, R01HL089897, P01 HL105339, K08 HL097029, R01 HL113264]; COPD Foundation; GSK FX This work was supported by National Institutes of Health grants R01 HL089856 (E.K.S.), R01 HL075478 (E.K.S), R01HL089897 (J.D.C.), P01 HL105339 (E.K.S.), K08 HL097029 (M.H.C), and R01 HL113264 (M.H.C.). The COPDGene study (NCT00608764) is also supported by the COPD Foundation through contributions made to an industry advisory board comprised of AstraZeneca, Boehringer Ingelheim, Novartis, Pfizer, Siemens, Sunovion and GlaxoSmithKline (GSK). The Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints study (NCT00292552; GSK code SCO104960) was sponsored by GSK. NR 56 TC 3 Z9 4 U1 1 U2 5 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1044-1549 EI 1535-4989 J9 AM J RESP CELL MOL JI Am. J. Respir. Cell Mol. Biol. PD MAR PY 2015 VL 52 IS 3 BP 365 EP 376 DI 10.1165/rcmb.2014-0210OC PG 12 WC Biochemistry & Molecular Biology; Cell Biology; Respiratory System SC Biochemistry & Molecular Biology; Cell Biology; Respiratory System GA CF0BS UT WOS:000352208100010 PM 25101718 ER PT J AU Thaler, NS Sayegh, P Kim, MS Castellon, SA Hinkin, CH AF Thaler, Nicholas S. Sayegh, Philip Kim, Michelle S. Castellon, Steven A. Hinkin, Charles H. TI Interactive Effects of Neurocognitive Impairment and Substance Use on Antiretroviral Non-adherence in HIV Disease SO ARCHIVES OF CLINICAL NEUROPSYCHOLOGY LA English DT Article DE HIV/AIDS; Drug and alcohol abuse ID MEDICATION ADHERENCE; NEUROPSYCHOLOGICAL IMPAIRMENT; INFECTED INDIVIDUALS; DEPRESSIVE SYMPTOMS; PROSPECTIVE MEMORY; VIRAL SUPPRESSION; DRUG-USE; ADULTS; METHAMPHETAMINE; PREDICTORS AB While numerous studies have established the adverse independent effects of clinical conditions including neurocognitive dysfunction, psychiatric illness, and substance abuse/dependence on medication adherence among HIV-infected adults, fewer have studied their interactive effects. The current study examined this issue among 204 HIV-infected participants based upon current neurocognitive functioning and DSM-IV-diagnosed psychiatric illness and current substance abuse or dependence. Results confirmed that participants with any of these risk factors demonstrated poorer adherence than individuals with no risk factors. A neurocognitive status x substance abuse/dependence interaction was also identified such that participants with impaired neurocognition and a co-occurring substance abuse/dependence diagnosis demonstrated the poorest adherence. Results confirm the deleterious impact of these risk factors in isolation and also identify a specific interactive effect for individuals with comorbid neurocognitive impairment and a substance abuse/dependence disorder. Findings highlight the need for interventions that simultaneously address these problems. C1 [Thaler, Nicholas S.; Sayegh, Philip; Castellon, Steven A.; Hinkin, Charles H.] Univ Calif Los Angeles, Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA. [Kim, Michelle S.] Univ Washington, Dept Neurol, Seattle, WA 98195 USA. [Castellon, Steven A.; Hinkin, Charles H.] VA Greater Los Angeles Healthcare Syst, Dept Psychol, Los Angeles, CA USA. RP Thaler, NS (reprint author), Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, 760 Westwood Plaza,C8-735, Los Angeles, CA 90024 USA. EM Nthaler@mednet.ucla.edu FU National Institutes of Health [R01 DA13799]; National Institutes of Health Ruth L. Kirschstein National Research Service award [T32 MH19535] FX This work was supported by National Institutes of Health grant R01 DA13799 and the National Institutes of Health Ruth L. Kirschstein National Research Service award T32 MH19535. NR 35 TC 3 Z9 3 U1 3 U2 7 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0887-6177 EI 1873-5843 J9 ARCH CLIN NEUROPSYCH JI Arch. Clin. Neuropsychol. PD MAR PY 2015 VL 30 IS 2 BP 114 EP 121 DI 10.1093/arclin/acu092 PG 8 WC Psychology, Clinical; Psychology SC Psychology GA CF0JP UT WOS:000352230000003 PM 25589442 ER PT J AU Schnabolk, G Coughlin, B Joseph, K Kunchithapautham, K Bandyopadhyay, M O'Quinn, EC Nowling, T Rohrer, B AF Schnabolk, Gloriane Coughlin, Beth Joseph, Kusumam Kunchithapautham, Kannan Bandyopadhyay, Mausumi O'Quinn, Elizabeth C. Nowling, Tamara Rohrer, Baerbel TI Local Production of the Alternative Pathway Component Factor B Is Sufficient to Promote Laser-Induced Choroidal Neovascularization SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Article DE alternative complement pathway; complement factor B; RPE-specific transgenic mouse; choroidal neovascularization; age-related macular degeneration ID COMPLEMENT FACTOR-H; PIGMENT EPITHELIAL-CELLS; MACULAR DEGENERATION; OXIDATIVE STRESS; MEDIATED INJURY; LECTIN PATHWAY; MOUSE MODEL; AGE; ACTIVATION; RISK AB PURPOSE. Complement factor B (CFB) is a required component of the alternative pathway (AP) of complement, and CFB polymorphisms are associated with age-related macular degeneration (AMD) risk. Complement factor B is made in the liver, but expression has also been detected in retina and retinal pigment epithelium (RPE)-choroid. We investigated whether production of CFB by the RPE can promote AP activation in mouse choroidal neovascularization (CNV). METHODS. Transgenic mice expressing CFB under the RPE65 promoter were generated and crossed onto factor B-deficient (CFB-KO) mice. Biological activity was determined in vitro using RPE monolayers and in vivo using laser-induced CNV. Contribution of systemic CFB was investigated using CFB-KO reconstituted with CFB-sufficient serum. RESULTS. Transgenic mice (CFB-tg) expressed CFB in RPE-choroid; no CFB was detected in serum. Cultured CFB-tg RPE monolayers secreted CFB apically and basally upon exposure to oxidative stress that was biologically active. Choroidal neovascularization sizes were comparable between wild-type and CFB-tg mice, but significantly increased when compared to lesions in CFB-KO mice. Injections of CFB-sufficient serum into CFB-KO mice resulted in partial reconstitution of systemic AP activity and significantly increased CNV size. CONCLUSIONS. Mouse RPE cells express and secrete CFB sufficient to promote RPE damage and CNV. This further supports that local complement production may regulate disease processes; however, the reconstitution experiments suggest that additional components may be sequestered from the bloodstream. Understanding the process of ocular complement production and regulation will further our understanding of the AMD disease process and the requirements of a complement-based therapeutic. C1 [Schnabolk, Gloriane; Rohrer, Baerbel] Ralph H Johnson VA Med Ctr, Res Serv, Charleston, SC USA. [Coughlin, Beth; Joseph, Kusumam; Kunchithapautham, Kannan; Bandyopadhyay, Mausumi; O'Quinn, Elizabeth C.; Rohrer, Baerbel] Med Univ S Carolina, Dept Ophthalmol, Charleston, SC 29425 USA. [Nowling, Tamara] Med Univ S Carolina, Dept Med, Div Rheumatol & Immunol, Charleston, SC 29425 USA. RP Rohrer, B (reprint author), Med Univ S Carolina, Dept Ophthalmol, 167 Ashley Ave, Charleston, SC 29425 USA. EM rohrer@musc.edu FU National Institutes of Health (NIH) [R01EY019320]; Department for Veteran Affairs Merit Award [RX000444]; Beckman Initiative for Macular Research; Medical University of South Carolina from Research to Prevent Blindness (RPB), New York, New York, United States; NIH [C06RR015455]; [AR053376]; [R03-NIAMS] FX Supported in the laboratory of BR in part by the National Institutes of Health (NIH R01EY019320); Department for Veteran Affairs Merit Award RX000444; the Beckman Initiative for Macular Research; an unrestricted grant to the Medical University of South Carolina from Research to Prevent Blindness (RPB), New York, New York, United States; and in the laboratory of TN by Grant AR053376 (R03-NIAMS). Animal studies were conducted in a facility constructed with support from NIH C06RR015455. NR 50 TC 3 Z9 3 U1 0 U2 1 PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC PI ROCKVILLE PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA SN 0146-0404 EI 1552-5783 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR PY 2015 VL 56 IS 3 BP 1850 EP 1863 DI 10.1167/iovs.14-15910 PG 14 WC Ophthalmology SC Ophthalmology GA CE9BF UT WOS:000352137600057 PM 25593023 ER PT J AU Kaup, AR Nettiksimmons, J Harris, TB Sink, KM Satterfield, S Metti, AL Ayonayon, HN Yaffe, K AF Kaup, Allison R. Nettiksimmons, Jasmine Harris, Tamara B. Sink, Kaycee M. Satterfield, Suzanne Metti, Andrea L. Ayonayon, Hilsa N. Yaffe, Kristine CA Hlth Aging Body Composition Hlth TI Cognitive Resilience to Apolipoprotein E epsilon 4 Contributing Factors in Black and White Older Adults SO JAMA NEUROLOGY LA English DT Article ID ALZHEIMER-DISEASE; AFRICAN-AMERICANS; BODY-COMPOSITION; VARIABLE IMPORTANCE; METABOLIC SYNDROME; RANDOM FORESTS; APOE GENOTYPE; RISK-FACTORS; DEMENTIA; COMMUNITY AB IMPORTANCE Apolipoprotein E (APOE) epsilon 4 is an established risk factor for cognitive decline and the development of dementia, but other factors may help to minimize its effects. OBJECTIVE Using APOE epsilon 4 as an indicator of high risk, we investigated factors associated with cognitive resilience among black and white older adults who are APOE epsilon 4 carriers. DESIGN, SETTING, AND PARTICIPANTS Participants included 2487 community-dwelling older (aged 69-80 years at baseline) black and white adults examined at 2 community clinics in the prospective cohort Health, Aging, and Body Composition (Health ABC) study. The baseline visits occurred from May 1997 through June 1998. Our primary analytic cohort consisted of 670 APOE epsilon 4 carriers (329 black and 341 white participants) who were free of cognitive impairment at baseline and underwent repeated cognitive testing during an 11-year follow-up (through 2008) using the Modified Mini-Mental State Examination. MAIN OUTCOMES AND MEASURES We stratified all analyses by race. Using the Modified Mini-Mental State Examination scores, we assessed normative cognitive change in the entire cohort (n = 2487) and classified the APOE epsilon 4 carriers as being cognitively resilient vs nonresilient by comparing their cognitive trajectories with those of the entire cohort. We then conducted bivariate analyses and multivariable random forest and logistic regression analyses to explore factors predictive of cognitive resilience in APOE epsilon 4 carriers. RESULTS Among white APOE epsilon 4 carriers, the strongest predictors of cognitive resilience were, in relative order of importance, no recent negative life events, a higher literacy level, advanced age, a higher educational level, and more time spent reading. Among black APOE epsilon 4 carriers, the strongest predictors of cognitive resilience were, in relative order of importance, a higher literacy level, a higher educational level, female sex, and the absence of diabetes mellitus. In follow-up logistic regression models, higher literacy level (adjusted odds ratio [OR], 9.50 [95% CI, 2.67-60.89]), a higher educational level (adjusted OR for college graduate vs less than high school, 3.81 [95% CI, 1.13-17.56]), and age (adjusted OR for 73-76 vs 69-72 years, 2.01 [95% CI, 1.13-3.63]) had significant independent effects in predicting cognitive resilience among white APOE epsilon 4 carriers. Among black APOE epsilon 4 carriers, a higher literacy level (adjusted OR, 2.27 [95% CI, 1.29-4.06]) and a higher educational level (adjusted OR for high school graduate/some college vs less than high school, 2.86 [95% CI, 1.54-5.49]; adjusted OR for college graduate vs less than high school, 2.52 [95% CI, 1.14-5.62]) had significant independent effects in predicting cognitive resilience. CONCLUSIONS AND RELEVANCE Although APOE epsilon 4 carriers are at high risk for cognitive decline, our findings suggest possible intervention targets, including the enhancement of cognitive reserve and improvement of other psychosocial and health factors, to promote cognitive resilience among black and white APOE epsilon 4 carriers. C1 [Kaup, Allison R.; Yaffe, Kristine] San Francisco VA Med Ctr, Sierra Pacific Mental Illness Res Educ & Clin Ctr, San Francisco, CA 94121 USA. [Kaup, Allison R.; Nettiksimmons, Jasmine; Yaffe, Kristine] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA. [Harris, Tamara B.] NIA, Lab Epidemiol & Populat Sci, Intramural Res Program, Bethesda, MD 20892 USA. [Sink, Kaycee M.] Wake Forest Sch Med, Dept Med, Sect Gerontol & Geriatr Med, Winston Salem, NC USA. [Satterfield, Suzanne] Univ Tennessee Hlth Sci Ctr, Dept Prevent Med, Memphis, TN USA. [Metti, Andrea L.] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA. [Ayonayon, Hilsa N.; Yaffe, Kristine] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA. [Yaffe, Kristine] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA. RP Kaup, AR (reprint author), San Francisco VA Med Ctr, Sierra Pacific Mental Illness Res Educ & Clin Ctr, 4150 Clement St,Mail Code T16H, San Francisco, CA 94121 USA. EM allison.kaup@ucsf.edu FU NIA [N01-AG-6-2101, N01-AG-6-2103, N01-AG-6-2106, R01-AG028050, K24AG031155]; National Institute on Nursing Research [R01-NR012459]; NIA/NIH; Department of Veterans Affairs Office of Academic Affiliations Advanced Fellowship Program in Mental Illness Research and Treatment; Medical Research Service of the San Francisco Veterans Affairs Medical Center; Sierra Pacific Mental Illness Research, Education, and Clinical Center FX This study was supported by contracts N01-AG-6-2101, N01-AG-6-2103, and N01-AG-6-2106 and grant R01-AG028050 from the NIA; by grant R01-NR012459 from the National Institute on Nursing Research; and in part by the Intramural Research Program of the NIA/NIH, all of which supported the design and conduct of the study; collection, management, analysis, and interpretation of the data; and review and approval of the manuscript. This study was also supported by grant K24AG031155 from the NIA (Dr Yaffe), which supported the design and conduct of the study, analysis and interpretation of the data, preparation and review of the manuscript, and decision to submit the manuscript for publication. Preparation of the manuscript was supported by the Department of Veterans Affairs Office of Academic Affiliations Advanced Fellowship Program in Mental Illness Research and Treatment, the Medical Research Service of the San Francisco Veterans Affairs Medical Center, and the Sierra Pacific Mental Illness Research, Education, and Clinical Center. NR 38 TC 5 Z9 5 U1 2 U2 6 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6149 EI 2168-6157 J9 JAMA NEUROL JI JAMA Neurol. PD MAR PY 2015 VL 72 IS 3 BP 340 EP 348 DI 10.1001/jamaneurol.2014.3978 PG 9 WC Clinical Neurology SC Neurosciences & Neurology GA CE9IJ UT WOS:000352157200015 PM 25599330 ER PT J AU Sakanaka, T Inoue, T Yorifuji, N Iguchi, M Fujiwara, K Narabayashi, K Kakimoto, K Nouda, S Okada, T Kuramoto, T Ishida, K Abe, Y Takeuchi, T Umegaki, E Akiba, Y Kaunitz, JD Higuchi, K AF Sakanaka, Taisuke Inoue, Takuya Yorifuji, Naoki Iguchi, Munetaka Fujiwara, Kaori Narabayashi, Ken Kakimoto, Kazuki Nouda, Sadaharu Okada, Toshihiko Kuramoto, Takanori Ishida, Kumi Abe, Yosuke Takeuchi, Toshihisa Umegaki, Eiji Akiba, Yasutada Kaunitz, Jonathan D. Higuchi, Kazuhide TI The effects of a TGR5 agonist and a dipeptidyl peptidase IV inhibitor on dextran sulfate sodium-induced colitis in mice SO JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY LA English DT Article; Proceedings Paper CT 15th Taishotoyama International Symposium on Gastroenterology CY SEP 26-28, 2013 CL Tokyo, JAPAN DE dextran sulfate sodium; DPPIV; GLP-2; sitagliptin; TGR5 ID L CELLS; EXPRESSION; SECRETION; ACID; LOCALIZATION; RAT AB Background and AimLuminal nutrients stimulate enteroendocrine L cells to release gut hormones, including intestinotrophic glucagon-like peptide-2 (GLP-2). Because L cells express the bile acid receptor TGR5 and dipeptidyl peptidase-IV (DPPIV) rapidly degrades GLPs, we hypothesized that luminal TGR5 activation may attenuate intestinal injury via GLP-2 release, which is enhanced by DPPIV inhibition. MethodsIntestinal injury was induced in mice by administration of dextran sulfate sodium (DSS) in drinking water (free access to water containing 5% DSS for 7 days). The selective TGR5 agonist betulinic acid (BTA) and the DPPIV inhibitor sitagliptin phosphate monohydrate (STG) were administered orally for 7 days. Male C57BL/6 mice (6-7 weeks old) were divided into five groups: normal control group, disease control group, BTA low group (drinking water containing 15mg/L BTA), BTA high group (50mg/L BTA), and BTA high+STG (3mg/kg, i.g.) group. ResultsThe selective TGR5 agonist BTA dose-dependently suppressed disease activity index and mRNA expression of the pro-inflammatory cytokines interleukin (IL)-1, IL-6, and tumor necrosis factor- in the colon. Nevertheless, STG administration had little additive effect on BTA-induced protection. Fibroblast activation protein mRNA expression, but not expression of other DPP family members, was increased in the colon of DSS-treated mice with increased mucosal DPPIV. Co-administration of the selective GLP-2 antagonist GLP-2 (3-33) reversed the effect of BTA. ConclusionThe selective TGR5 agonist BTA ameliorated DSS-induced colitis in mice via the GLP-2 pathway with no effect of DPPIV inhibition, suggesting that other DPP enzymatic activity is involved in GLP-2 degradation. C1 [Sakanaka, Taisuke; Inoue, Takuya; Yorifuji, Naoki; Iguchi, Munetaka; Fujiwara, Kaori; Narabayashi, Ken; Kakimoto, Kazuki; Nouda, Sadaharu; Okada, Toshihiko; Kuramoto, Takanori; Ishida, Kumi; Abe, Yosuke; Takeuchi, Toshihisa; Umegaki, Eiji; Higuchi, Kazuhide] Osaka Med Coll, Dept Internal Med 2, Takatsuki, Osaka 5698686, Japan. [Akiba, Yasutada; Kaunitz, Jonathan D.] Univ Calif Los Angeles, Greater Los Angeles Vet Affairs Healthcare Syst, Los Angeles, CA USA. EM ureuretakuwan@yahoo.co.jp FU Intramural VA [VA999999]; NIDDK NIH HHS [P30 DK041301, R01 DK054221] NR 27 TC 5 Z9 5 U1 1 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0815-9319 EI 1440-1746 J9 J GASTROEN HEPATOL JI J. Gastroenterol. Hepatol. PD MAR PY 2015 VL 30 SU 1 SI SI BP 60 EP 65 DI 10.1111/jgh.12740 PG 6 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA CF0IU UT WOS:000352227600013 PM 25827806 ER PT J AU Turner, PV Pekow, C Clark, JM Vergara, P Bayne, K White, WJ Kurosawa, TM Seok, SH Baneux, P AF Turner, Patricia V. Pekow, Cynthia Clark, Judy MacArthur Vergara, Patri Bayne, Kathryn White, William J. Kurosawa, Tsutomu Miki Seok, Seung-Hyeok Baneux, Philippe TI Roles of the International Council for Laboratory Animal Science (ICLAS) and International Association of Colleges of Laboratory Animal Medicine (IACLAM) in the Global Organization and Support of 3Rs Advances in Laboratory Animal Science SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE LA English DT Article ID VETERINARY-CARE; HARMONIZATION; GUIDELINES; NEEDS AB Practical implementation of the 3Rs at national and regional levels around the world requires long-term commitment, backing, and coordinated efforts by international associations for laboratory animal medicine and science, including the International Association of Colleges of Laboratory Animal Medicine (IACLAM) and the International Council for Laboratory Animal Science (ICLAS). Together these organizations support the efforts of regional organization and communities of laboratory animal science professionals as well as the development of local associations and professional colleges that promote the training and continuing education of research facility personnel and veterinary specialists. The recent formation of a World Organization for Animal Health (OIE) Collaborating Center for Laboratory Animal Science and Welfare emphasizes the need for research into initiatives promoting laboratory animal welfare, particularly in emerging economies and regions with nascent associations of laboratory animal science. C1 [Turner, Patricia V.] Univ Guelph, Dept Pathobiol, Guelph, ON N1G 2W1, Canada. [Pekow, Cynthia] Vet Affairs Puget Sound Hlth Care Syst, Res & Dev, Seattle, WA USA. [Clark, Judy MacArthur] Home Off, Anim Sci Regulat Unit, London, England. [Vergara, Patri] Autonomous Univ Barcelona, Fac Vet Med, Physiol Unit, Barcelona, Spain. [Bayne, Kathryn] Assoc Assessment & Accreditat Lab Anim Care Int, Frederick, MD USA. [White, William J.] Charles River, Vet & Profess Serv, Wilmington, MA USA. [Kurosawa, Tsutomu Miki] Osaka Univ, Inst Expt Anim Sci, Dept Lab Anim Med, Osaka, Japan. [Seok, Seung-Hyeok] Seoul Natl Univ, Dept Microbiol & Immunol, Seoul, South Korea. [Baneux, Philippe] Cornell Univ, Cornell Ctr Anim Resources & Educ, Ithaca, NY USA. RP Turner, PV (reprint author), Univ Guelph, Dept Pathobiol, Guelph, ON N1G 2W1, Canada. EM pvturner@uoguelph.ca RI Vergara, Patrocinio/M-6468-2013 OI Vergara, Patrocinio/0000-0002-9220-6406 NR 22 TC 3 Z9 3 U1 0 U2 2 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1559-6109 J9 J AM ASSOC LAB ANIM JI J. Amer. Assoc. Lab. Anim. Sci. PD MAR PY 2015 VL 54 IS 2 BP 174 EP 180 PG 7 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA CE8UJ UT WOS:000352119300009 PM 25836964 ER PT J AU Friedlander, AH Hazboun, RC AF Friedlander, Arthur H. Hazboun, Renna C. TI ANTIBIOTICS AND IMPLANTS SO JOURNAL OF THE AMERICAN DENTAL ASSOCIATION LA English DT Editorial Material C1 [Friedlander, Arthur H.] VA Greater Los Angeles Healthcare Syst, Grad Med Educ, Los Angeles, CA 90073 USA. [Friedlander, Arthur H.] Univ Calif Los Angeles, Sch Dent, Hosp Dent Serv, Oral & Maxillofacial Surg, Los Angeles, CA USA. [Friedlander, Arthur H.] Univ Calif Los Angeles, Sch Dent, Hosp Dent Serv, Qual Assurance, Los Angeles, CA USA. [Friedlander, Arthur H.] Univ Calif Los Angeles, Med Ctr, Los Angeles, CA 90024 USA. [Hazboun, Renna C.] VA Greater Los Angeles Healthcare Syst, Oral & Maxillofacial Surg Res, Los Angeles, CA USA. RP Friedlander, AH (reprint author), VA Greater Los Angeles Healthcare Syst, Grad Med Educ, Los Angeles, CA 90073 USA. NR 4 TC 0 Z9 0 U1 0 U2 1 PU AMER DENTAL ASSOC PI CHICAGO PA 211 E CHICAGO AVE, CHICAGO, IL 60611 USA SN 0002-8177 EI 1943-4723 J9 J AM DENT ASSOC JI J. Am. Dent. Assoc. PD MAR PY 2015 VL 146 IS 3 BP 146 EP 146 DI 10.1016/j.adaj.2015.01.008 PG 1 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA CE9GR UT WOS:000352152600006 PM 25726341 ER PT J AU Hsieh, YH Leung, FW AF Hsieh, Yu-Hsi Leung, Felix W. TI The Ideal Insertion Method for Colonoscopy Is in the Eye of the Beholder Response SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Letter ID MINIMALLY SEDATED COLONOSCOPY; CONTROLLED-TRIAL C1 [Hsieh, Yu-Hsi] Buddhist Tzu Chi Med Fdn, Dalin Tzu Chi Hosp, Dept Med, Div Gastroenterol, Chiayi 62247, Taiwan. [Hsieh, Yu-Hsi] Tzu Chi Univ, Sch Med, Hualien, Taiwan. [Leung, Felix W.] Vet Affairs Greater Los Angeles Healthcare Syst, Sepulveda Ambulatory Care Ctr, North Hill, CA USA. [Leung, Felix W.] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA. RP Hsieh, YH (reprint author), Buddhist Tzu Chi Med Fdn, Dalin Tzu Chi Hosp, Dept Med, Div Gastroenterol, 2 Minsheng Rd, Chiayi 62247, Taiwan. EM hsieh.yuhsi@msa.hinet.net NR 5 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD MAR PY 2015 VL 110 IS 3 BP 475 EP 476 DI 10.1038/ajg.2015.15 PG 4 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA CE6AF UT WOS:000351917100022 PM 25743719 ER PT J AU Mauck, RL Burdick, JA AF Mauck, Robert L. Burdick, Jason A. TI From Repair to Regeneration: Biomaterials to Reprogram the Meniscus Wound Microenvironment SO ANNALS OF BIOMEDICAL ENGINEERING LA English DT Article DE Meniscus; Biomaterials; Wound healing; Regeneration; Scaffold; Extracellular matrix ID STEM-CELL DIFFERENTIATION; NECROSIS-FACTOR-ALPHA; HUMAN KNEE-JOINT; IN-VITRO; NUCLEAR MECHANICS; HYALURONIC-ACID; SYNOVIAL-FLUID; 3-DIMENSIONAL HYDROGELS; NANOFIBROUS SCAFFOLDS; PARTIAL MENISCECTOMY AB When the field of tissue engineering first arose, scaffolds were conceived of as inert three-dimensional structures whose primary function was to support cellularity and tissue growth. Since then, advances in scaffold and biomaterial design have evolved to not only guide tissue formation, but also to interact dynamically with and manipulate the wound environment. At present, these efforts are being directed towards strategies that directly address limitations in endogenous wound repair, with the goal of reprogramming the local wound environment (and the cells within that locality) from a state that culminates in an inferior tissue repair into a state in which functional regeneration is achieved. This review will address this approach with a focus on recent advances in scaffold design towards the resolution of tears of the knee meniscus as a case example. The inherent limitations to endogenous repair will be discussed, as will specific examples of how biomaterials are being designed to overcome these limitations. Examples will include design of fibrous scaffolds that promote colonization by modulating local extracellular matrix density and delivering recruitment factors. Furthermore, we will discuss scaffolds that are themselves modulated by the wound environment to alter porosity and modulate therapeutic release through precise coordination of scaffold degradation. Finally, we will close with emerging concepts in local control of cell mechanics to improve interstitial cell migration and so advance repair. Overall, these examples will illustrate how emergent features within a biomaterial can be tuned to manipulate and harness the local tissue microenvironment in order to promote robust regeneration. C1 [Mauck, Robert L.] Univ Penn, McKay Orthopaed Res Lab, Dept Orthopaed Surg, Perelman Sch Med, Philadelphia, PA 19104 USA. [Burdick, Jason A.] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA. [Mauck, Robert L.; Burdick, Jason A.] Philadelphia VA Med Ctr, Translat Musculoskeletal Res Ctr, Philadelphia, PA 19104 USA. RP Mauck, RL (reprint author), Univ Penn, McKay Orthopaed Res Lab, Dept Orthopaed Surg, Perelman Sch Med, 424 Stemmler Hall,36th St & Hamilton Walk, Philadelphia, PA 19104 USA. EM lemauck@mail.med.upenn.edu; burdick2@seas.upenn.edu FU National Institutes of Health [R01 EB008722, AR056624]; Department of Veterans Affairs [I01 RX000700, RX000174] FX This work was supported with grants from the National Institutes of Health (R01 EB008722 and AR056624) and the Department of Veterans Affairs (I01 RX000700 and RX000174). The authors gratefully acknowledge Dr. Brendon Baker, Dr. Matt Fisher, Dr. Lara Ionescu, Dr. Iris Kim, Dr. Brendan Purcell, and Ms. Feini (Sylvia) Qu for their helpful input, graphical design, and in depth discussions on this topic. NR 122 TC 9 Z9 9 U1 3 U2 29 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0090-6964 EI 1573-9686 J9 ANN BIOMED ENG JI Ann. Biomed. Eng. PD MAR PY 2015 VL 43 IS 3 BP 529 EP 542 DI 10.1007/s10439-015-1249-z PG 14 WC Engineering, Biomedical SC Engineering GA CE3QF UT WOS:000351742500005 PM 25650096 ER PT J AU Javidi-Sharifi, N Traer, E Martinez, J Gupta, A Taguchi, T Dunlap, J Heinrich, MC Corless, CL Rubin, BP Druker, BJ Tyner, JW AF Javidi-Sharifi, Nathalie Traer, Elie Martinez, Jacqueline Gupta, Anu Taguchi, Takehiro Dunlap, Jennifer Heinrich, Michael C. Corless, Christopher L. Rubin, Brian P. Druker, Brian J. Tyner, Jeffrey W. TI Crosstalk between KIT and FGFR3 Promotes Gastrointestinal Stromal Tumor Cell Growth and Drug Resistance SO CANCER RESEARCH LA English DT Article ID PROSTATE-CANCER; FACTOR RECEPTOR-3; LUNG-CANCER; B-RAF; SURVIVAL; LEUKEMIA; IMATINIB; MUTATION; KINASE; MECHANISMS AB Kinase inhibitors such as imatinib have dramatically improved outcomes for patients with gastrointestinal stromal tumor (GIST), but many patients develop resistance to these treatments. Although in some patients this event corresponds with mutations in the GIST driver oncogenic kinase KIT, other patients develop resistance without KIT mutations. In this study, we address this patient subset in reporting a functional dependence of GIST on the FGF receptor FGFR3 and its crosstalk with KIT in GIST cells. Addition of the FGFR3 ligand FGF2 to GIST cells restored KIT phosphorylation during imatinib treatment, allowing sensitive cells to proliferate in the presence of the drug. FGF2 expression was increased in imatinib-resistant GIST cells, the growth of which was blocked by RNAi-mediated silencing of FGFR3. Moreover, combining KIT and FGFR3 inhibitors synergized to block the growth of imatinib-resistant cells. Signaling crosstalk between KIT and FGFR3 activated the MAPK pathway to promote resistance to imatinib. Clinically, an IHC analysis of tumor specimens from imatinib-resistant GIST patients revealed a relative increase in FGF2 levels, with a trend toward increased expression in imatinib-naive samples consistent with possible involvement in drug resistance. Our findings provide a mechanistic rationale to evaluate existing FGFR inhibitors and multikinase inhibitors that target FGFR3 as promising strategies to improve treatment of patients with GIST with de novo or acquired resistance to imatinib. (C)2014 AACR. C1 [Javidi-Sharifi, Nathalie; Traer, Elie; Martinez, Jacqueline; Dunlap, Jennifer; Heinrich, Michael C.; Corless, Christopher L.; Druker, Brian J.; Tyner, Jeffrey W.] Oregon Hlth & Sci Univ, Knight Canc Inst, Portland, OR 97239 USA. [Javidi-Sharifi, Nathalie; Traer, Elie; Heinrich, Michael C.; Druker, Brian J.] Oregon Hlth & Sci Univ, Div Hematol & Med Oncol, Portland, OR 97239 USA. [Gupta, Anu; Rubin, Brian P.] Lerner Res Inst, Dept Mol Genet, Cleveland, OH USA. [Taguchi, Takehiro] Kochi Univ, Grad Sch Kuroshio Sci, Div Human Hlth & Med Sci, Nankoku, Kochi, Japan. [Dunlap, Jennifer; Corless, Christopher L.] Oregon Hlth & Sci Univ, Depat Anat Pathol, Portland, OR 97239 USA. [Heinrich, Michael C.] Portland VA Med Ctr, Portland, OR USA. [Rubin, Brian P.] Cleveland Clin, Taussig Canc Ctr, Cleveland, OH 44106 USA. [Rubin, Brian P.] Cleveland Clin, Dept Anat Pathol, Cleveland, OH 44106 USA. [Druker, Brian J.] Howard Hughes Med Inst, Portland, OR USA. [Tyner, Jeffrey W.] Oregon Hlth & Sci Univ, Dept Cell Dev & Canc Biol, Portland, OR 97239 USA. RP Tyner, JW (reprint author), Oregon Hlth & Sci Univ, Knight Canc Inst, 3181 Southwest Sam Jackson Pk Rd,Mailcode L592, Portland, OR 97239 USA. EM tynerj@ohsu.edu FU Oregon Clinical and Translational Research Institute (OCTRI); National Center for Advancing Translational Sciences (NCATS) [TL1 RR024159]; NIH; NIH Roadmap for Medical Research; V Foundation for Cancer Research; Leukemia and Lymphoma Society; Gabrielle's Angel Foundation for Cancer Research; National Cancer Institute [5R00CA151457-04, 1R01CA183974-01]; Life Raft Group FX N. Javidi-Sharifi was supported by the Oregon Clinical and Translational Research Institute (OCTRI), grant number TL1 RR024159 from the National Center for Advancing Translational Sciences (NCATS), a component of the NIH, and NIH Roadmap for Medical Research. B.J. Druker was an investigator of the Howard Hughes Medical Institute. J.W. Tyner was supported by grants from the V Foundation for Cancer Research, The Leukemia and Lymphoma Society, the Gabrielle's Angel Foundation for Cancer Research, and the National Cancer Institute (5R00CA151457-04; 1R01CA183974-01). B.P. Rubin and A. Gupta were supported by the Life Raft Group. NR 34 TC 17 Z9 17 U1 2 U2 10 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD MAR 1 PY 2015 VL 75 IS 5 BP 880 EP 891 DI 10.1158/0008-5472.CAN-14-0573 PG 12 WC Oncology SC Oncology GA CE6GG UT WOS:000351934100012 PM 25432174 ER PT J AU Deutsch, MB Mendez, MF AF Deutsch, Mariel B. Mendez, Mario F. TI Neurocognitive Features Distinguishing Primary Central Nervous System Lymphoma from Other Possible Causes of Rapidly Progressive Dementia SO COGNITIVE AND BEHAVIORAL NEUROLOGY LA English DT Review DE dementia; lymphoma; neurologic manifestations; neuropsychiatry ID PRIMARY CNS LYMPHOMA; CEREBRI; LEUKOENCEPHALOPATHY; MANIFESTATIONS; DIAGNOSIS; SURVIVAL AB Objective: Define the neurocognitive features of primary central nervous system lymphoma (PCNSL) presenting with dementia, and compare with other causes of rapidly progressive dementia (RPD). Background: PCNSL can present as an RPD. Differentiating PCNSL from other RPDs is critical because lymphomatous dementia may be reversible, and untreated PCNSL is fatal. Methods: We performed a meta-analysis of case reports of dementia from PCNSL (between 1950 and 2013); 20 patients (14 with lymphomatosis cerebri) met our criteria. We compared these patients to a case series of patients with RPD from Creutzfeldt-Jakob disease and other non-PCNSL etiologies (Sala et al, 2012. Alzheimer Dis Assoc Disord. 26:267-271). Results: Median age was 66 years (range 41 to 81); 70% were men. Time from symptom onset to evaluation was <6 months in 65%. No patients had seizures; 5% had headaches; 45% had non-aphasic speech difficulty. There was significantly more memory impairment in patients with PCNSL than other RPDs and significantly less myoclonus and parkinsonism. Behavioral changes and cerebellar signs were not significantly different. Significantly more patients with PCNSL than other RPDs had white matter changes; significantly fewer had atrophy. Elevated CSF protein and pleocytosis were more frequent in PCNSL; patients with other RPDs tended to have normal CSF +/- 14-3-3 protein. Conclusions: Unlike patients with RPD from other causes, those with PCNSL commonly present with impaired memory, apathy, and abnormal speech and gait, without headache, seizure, or myoclonus. White matter changes and CSF abnormalities pre-dominate. Improved clinical awareness of PCNSL can prompt earlier diagnosis and treatment. C1 [Deutsch, Mariel B.; Mendez, Mario F.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA. [Mendez, Mario F.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA. [Deutsch, Mariel B.; Mendez, Mario F.] Vet Affairs Greater Los Angeles Healthcare Syst, Neurobehav Unit, Los Angeles, CA 90073 USA. RP Deutsch, MB (reprint author), Vet Affairs Greater Los Angeles Healthcare Syst, Neurobehav Unit 116AF, 11301 Wilshire Blvd, Los Angeles, CA 90073 USA. EM marielbrooke@ucla.edu OI Deutsch, Mariel/0000-0003-1228-8868 FU National Institute on Aging [5R01AG034499] FX Supported in part by National Institute on Aging Grant 5R01AG034499 (M.F.M.). NR 30 TC 2 Z9 3 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1543-3633 EI 1543-3641 J9 COGN BEHAV NEUROL JI Cogn. Behav. Neurol. PD MAR PY 2015 VL 28 IS 1 BP 1 EP 10 PG 10 WC Behavioral Sciences; Clinical Neurology SC Behavioral Sciences; Neurosciences & Neurology GA CE5NI UT WOS:000351882000001 PM 25812125 ER PT J AU Ahnen, DJ Bresalier, RS Levin, B Kaunitz, JD AF Ahnen, Dennis J. Bresalier, Robert S. Levin, Bernard Kaunitz, Jonathan D. TI CRC Screening, Past, Present, and Future: A Tribute to Emmet Keeffe SO DIGESTIVE DISEASES AND SCIENCES LA English DT Editorial Material C1 [Ahnen, Dennis J.] Univ Colorado, Sch Med, Denver, CO 80204 USA. [Ahnen, Dennis J.] Gastroenterol Rockies, Boulder, CO USA. [Bresalier, Robert S.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. [Levin, Bernard] New York City Colon Canc Control Coalit, New York, NY USA. [Kaunitz, Jonathan D.] Greater Los Angeles VA Healthcare Syst, Los Angeles, CA USA. [Kaunitz, Jonathan D.] UCLA Sch Med, Los Angeles, CA USA. RP Ahnen, DJ (reprint author), Univ Colorado, Sch Med, Denver, CO 80204 USA. EM dennis.ahnen@ucdenver.edu FU NCI NIH HHS [R01 CA068099] NR 5 TC 1 Z9 1 U1 0 U2 1 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0163-2116 EI 1573-2568 J9 DIGEST DIS SCI JI Dig. Dis. Sci. PD MAR PY 2015 VL 60 IS 3 SI SI BP 589 EP 591 DI 10.1007/s10620-015-3603-2 PG 3 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA CE5GC UT WOS:000351858100001 PM 25724168 ER PT J AU Chacko, L Macaron, C Burke, CA AF Chacko, Lyssa Macaron, Carole Burke, Carol A. TI Colorectal Cancer Screening and Prevention in Women SO DIGESTIVE DISEASES AND SCIENCES LA English DT Review DE Colorectal cancer; Colorectal cancer prevention; Colorectal cancer screening; Colorectal cancer and women ID BODY-MASS INDEX; RANDOMIZED CONTROLLED-TRIAL; SESSILE SERRATED ADENOMAS; ESTROGEN PLUS PROGESTIN; HIGH-FIBER DIET; COLON-CANCER; CIGARETTE-SMOKING; NEGATIVE COLONOSCOPY; DIABETES-MELLITUS; FOLLOW-UP AB Colorectal cancer (CRC) is one of the leading cancers and cause of cancer deaths in American women and men. Females and males share a similar lifetime cumulative risk of CRC however, substantial differences in risk factors, tumor biology, and effectiveness of cancer prevention services have been observed between them. This review distills the evidence documenting the unique variation observed between the genders relating to CRC risk factors, screening and prevention. Consistent evidence throughout the world demonstrates that women reach equivalent levels of adenomas and CRC as men but it occurs nearly a decade later in life than in their male counterparts. Women have a higher proportion of tumors which are hypermethylated, have microsatellite instability and located in the proximal colon suggesting the serrated pathway may be of greater consequence in them than in men. Other CRC risk factors such as smoking, diet and obesity have been shown to have disparate effects on women which may related to interactions between estrogen exposure, body fat distribution, and the biologic underpinnings of their tumors. There is data showing the uptake, choice, and efficacy of different CRC screening methods in women is dissimilar to that in men. The mortality benefit from FOBT, sigmoidoscopy, and protection from interval CRC by colonoscopy appears to be lower in women than men. A greater understanding of these gender idiosyncrasies will facilitate an personalized approach to CRC prevention and should ultimately lead to a reduced burden of disease. C1 [Chacko, Lyssa] Denver Vet Affairs Med Ctr, Dept Gastroenterol & Hepatol, Denver, CO USA. [Macaron, Carole; Burke, Carol A.] Cleveland Clin, Dept Gastroenterol & Hepatol, Cleveland, OH 44195 USA. RP Burke, CA (reprint author), Cleveland Clin, Dept Gastroenterol & Hepatol, Desk A 30,9500 Euclid Ave, Cleveland, OH 44195 USA. EM Burkec1@ccf.org NR 148 TC 3 Z9 3 U1 1 U2 5 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0163-2116 EI 1573-2568 J9 DIGEST DIS SCI JI Dig. Dis. Sci. PD MAR PY 2015 VL 60 IS 3 SI SI BP 698 EP 710 DI 10.1007/s10620-014-3452-4 PG 13 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA CE5GC UT WOS:000351858100015 PM 25596719 ER PT J AU Cadoni, S Sanna, S Gallittu, P Argiolas, M Fanari, V Porcedda, ML Erriu, M Leung, FW AF Cadoni, Sergio Sanna, Stefano Gallittu, Paolo Argiolas, Mariangela Fanari, Viviana Porcedda, Maria L. Erriu, Matteo Leung, Felix W. TI A randomized, controlled trial comparing real-time insertion pain during colonoscopy confirmed water exchange to be superior to water immersion in enhancing patient comfort SO GASTROINTESTINAL ENDOSCOPY LA English DT Article ID CARBON-DIOXIDE INSUFFLATION; UNSEDATED COLONOSCOPY; AIR INSUFFLATION; AIDED COLONOSCOPY; MINIMAL SEDATION; US VETERANS; INFUSION; MEMORIES AB Background: A recent American Society for Gastrointestinal Endoscopy Technology Status Evaluation Report recommended comparative studies of water-aided colonoscopy methods to refine the optimal insertion technique. Objective: Air insufflation (AI), water immersion (WI), and water exchange (WE) were compared head-to-head to test the hypothesis that WE produces the least insertion pain. Design: Patient-blinded, prospective, randomized, controlled trials. Setting: Two community hospitals in Italy. Patients: First-time diagnostic or screening colonoscopy in unsedated patients with the option of on-demand sedation. Intervention: Colonoscopy with AI, WI, or WE. Main Outcome Measurements: Real-time maximum insertion pain (0 = none, 10 = worst). To avoid interventional bias, the timing of recording was at the discretion of the nurse assistant. Adjunct measures were implemented to ensure patient perception of minimal discomfort. Recalled pain and patients' guess of insertion methods were recorded after colonoscopy. Results: Results were merged for 576 randomized patients. Correct patient guesses lower than 33% confirmed adequate blinding. Significant correlation (Pearson coefficient 0.6, P < .0005) between real-time and recalled pain provided internal validation of the former as the primary outcome. Real-time pain (95% confidence interval [CI]: AI, 4.1 [3.7-4.5]; WI, 3.5 [3.0-3.9]; and WE, 2.5 [2.2-2.9] [P < .0005] was the lowest in the WE group. The proportions of patients completing unsedated colonoscopy based on the assigned methods were significantly different (WE, 74.7% vs WI, 62.4%; P = .009; vs AI, 65.3%; P = .04). WE required the least implementation of adjunct maneuvers. Limitations: Unblinded colonoscopists. Conclusion: The current findings with an internally validated primary outcome in adequately blinded patients support the hypothesis that WE is superior to WI in attenuating real-time insertion pain and enhancing completion of unsedated colonoscopy. C1 [Cadoni, Sergio; Gallittu, Paolo] S Barbara Hosp, Digest Endoscopy Unit, I-09016 Iglesias, CI, Italy. [Sanna, Stefano; Argiolas, Mariangela; Fanari, Viviana; Porcedda, Maria L.] NS di Bonaria Hosp, Digest Endoscopy Unit, San Gavino Monreale, Italy. [Erriu, Matteo] Univ Cagliari, Dept Surg Sci, Cagliari, Italy. [Leung, Felix W.] Univ Calif Los Angeles, Vet Affairs Greater Los Angeles Healthcare Syst, Sepulveda Ambulatory Care Ctr, North Hills, CA USA. [Leung, Felix W.] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA. RP Cadoni, S (reprint author), S Barbara Hosp, Digest Endoscopy Unit, Via S Leonardo 1, I-09016 Iglesias, CI, Italy. NR 27 TC 16 Z9 16 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0016-5107 EI 1097-6779 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD MAR PY 2015 VL 81 IS 3 BP 557 EP 566 DI 10.1016/j.gie.2014.07.029 PG 10 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA CE2SI UT WOS:000351666800009 PM 25262100 ER PT J AU Cuthbertson, DW Raol, N Hicks, J Green, L Parke, R AF Cuthbertson, David W. Raol, Nikhila Hicks, John Green, Linda Parke, Robert TI Minor Salivary Gland Basal Cell Adenocarcinoma A Systematic Review and Report of a New Case SO JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Review ID OF-THE-LITERATURE; SINGLE INSTITUTION EXPERIENCE; PAROTID-GLAND; TUMORS; PALATE; POPULATION; CARCINOMAS; CANCER; INDIA; HEAD AB IMPORTANCE Basal cell adenocarcinoma (BCAC) of the minor salivary gland is an extremely rare disease: the most recent substantive literature review reports only 25 cases. Owing to the rarity of this disease, it has not yet been well characterized in the literature. OBJECTIVE We sought to expand the knowledge of minor salivary gland BCAC by performing an exhaustive literature review and adding to it a new case that is rare owing to the tumor's size, aggressive nature, and mixed histologic pattern. The review emphasizes epidemiologic patterns, diagnostic characteristics, treatment patterns, and expected prognosis for minor salivary gland BCAC. EVIDENCE ACQUISITION In June 2012, PubMed was queried using the term "salivary gland basal cell adenocarcinoma," and the resultant articles were reviewed. Those specifically mentioning a minor salivary gland BCAC were included in this study. Those that did not differentiate minor salivary gland BCAC from major salivary gland BCAC were excluded. The search was not limited by language and included articles from North America, Europe, Africa, and Asia from 1978 to June 2012. RESULTS The PubMed search resulted in 195 articles, of which 33 articles reported at least 1 case of minor salivary gland BCAC. We report herein 72 cases of minor salivary gland BCAC (71 cases from the literature review and 1 new case reported herein). The mean patient age at the time of presentation was 56 years (range, 24-90 years), and the disease showed no sex predilection. The most common location was the palate, and the average lesions size was 2.4 cm (range, 0.7-4.2 cm). The treatment modality of choice was wide local excision (n = 57; 79%). There was a high local recurrence rate (n = 30; 41%) but a low rate of distant metastasis (n = 8; 11%). CONCLUSIONS AND RELEVANCE We present a comprehensive review of minor salivary gland BCAC, describing nearly 3 times as many cases as has been previously reported. This review characterizes a rare disease and increases awareness of the disease among otolaryngologists. Minor salivary gland BCAC is similar to major salivary gland BCAC and minor salivary gland tumors in general with regard to patient age, sex, tumor site, treatment modality, recurrence, metastasis, and mortality. C1 [Cuthbertson, David W.; Raol, Nikhila; Parke, Robert] Baylor Coll Med, Bobby R Alford Dept Otolaryngol Head & Neck Surg, Houston, TX 77030 USA. [Hicks, John; Green, Linda] Baylor Coll Med, Dept Pathol & Immunol, Houston, TX 77030 USA. [Green, Linda; Parke, Robert] Michael E Debakey Dept Vet Affairs Med Ctr, Houston, TX USA. RP Cuthbertson, DW (reprint author), Baylor Coll Med, Bobby R Alford Dept Otolaryngol Head & Neck Surg, One Baylor Plaza, Houston, TX 77030 USA. EM dwcuthbe@bcm.edu NR 45 TC 0 Z9 0 U1 0 U2 3 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6181 EI 2168-619X J9 JAMA OTOLARYNGOL JI JAMA Otolaryngol-Head Neck Surg. PD MAR PY 2015 VL 141 IS 3 BP 276 EP 283 DI 10.1001/jamaoto.2014.3344 PG 8 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA CE1PV UT WOS:000351585000014 PM 25555241 ER PT J AU Nicksa, GA Anderson, C Fidler, R Stewart, L AF Nicksa, Grace A. Anderson, Cristan Fidler, Richard Stewart, Lygia TI Innovative Approach Using Interprofessional Simulation to Educate Surgical Residents in Technical and Nontechnical Skills in High-Risk Clinical Scenarios SO JAMA SURGERY LA English DT Article ID GRADUATE MEDICAL-EDUCATION; ACCREDITATION COUNCIL; PROGRAM DIRECTORS; AMERICAN-COLLEGE; SURGERY; IMPLEMENTATION; CHALLENGES; BEHAVIOR; IMPACT AB IMPORTANCE The Accreditation Council for Graduate Medical Education core competencies stress nontechnical skills that can be difficult to evaluate and teach to surgical residents. During emergencies, surgeons work in interprofessional teams and are required to perform certain procedures. To obtain proficiency in these skills, residents must be trained. OBJECTIVE To educate surgical residents in leadership, teamwork, effective communication, and infrequently performed emergency surgical procedures with the use of interprofessional simulations. DESIGN, SETTING, AND PARTICIPANTS SimMan 3GS was used to simulate high-risk clinical scenarios (15-20 minutes), followed by debriefings with real-time feedback (30 minutes). A modified Oxford Non-Technical Skills scale (score range, 1-4) was used to assess surgical resident performance during the first half of the academic year (July-December 2012) and the second half of the academic year (January-June 2013). Anonymous online surveys were used to solicit participant feedback. Simulations were conducted in the operating room, intensive care unit, emergency department, ward, and simulation center. A total of 43 surgical residents (postgraduate years [PGYs] 1 and 2) participated in interdisciplinary clinical scenarios, with other health care professionals (nursing, anesthesia, critical care, medicine, respiratory therapy, and pharmacy; mean number of nonsurgical participants/session: 4, range 0-9). Thirty seven surgical residents responded to the survey. EXPOSURES Simulation of high-risk clinical scenarios: postoperative pulmonary embolus, pneumothorax, myocardial infarction, gastrointestinal bleeding, anaphylaxis with a difficult airway, and pulseless electrical activity arrest. MAIN OUTCOMES AND MEASURES Evaluation of resident skills: communication, leadership, teamwork, problem solving, situation awareness, and confidence in performing emergency procedures (eg, cricothyroidotomy). RESULTS A total of 31 of 35 (89%) of the residents responding found the sessions useful. Additionally, 28 of 33 (85%) reported improved confidence doing procedures and 29 of 37 (78%) reported knowing when the procedure should be applied. Oxford Non-Technical Skills evaluation demonstrated significant improvement in PGY 2 resident performance assessed during the 2 study periods: communication score increased from 3 to 3.71 (P = .01), leadership score increased from 2.77 to 3.86 (P < .001), teamwork score increased from 3.15 to 3.86 (P = .007), and procedural ability score increased from 2.23 to 3.43 (P = .03). There were no statistically significant improved scores in PGY 2 decision making or situation awareness. No improvements in skills were seen among PGY 1 participants. CONCLUSIONS AND RELEVANCE The PGY 2 residents improved their skills, but the PGY 1 residents did not. Participants found interprofessional simulations to be realistic and a valuable educational tool. Interprofessional simulation provides a valuable means of educating surgical residents and evaluating their skills in real-life clinical scenarios. C1 [Nicksa, Grace A.; Anderson, Cristan; Fidler, Richard; Stewart, Lygia] San Francisco VA Med Ctr, Dept Surg, San Francisco, CA 94121 USA. [Nicksa, Grace A.; Anderson, Cristan; Stewart, Lygia] Univ Calif San Francisco, Dept Surg, San Francisco, CA 94121 USA. RP Stewart, L (reprint author), San Francisco VA Med Ctr, Dept Surg, 4150 Clement St, San Francisco, CA 94121 USA. EM lygia.stewart@va.gov NR 24 TC 10 Z9 12 U1 0 U2 11 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6254 EI 2168-6262 J9 JAMA SURG JI JAMA Surg. PD MAR PY 2015 VL 150 IS 3 BP 201 EP 207 DI 10.1001/jamasurg.2014.2235 PG 7 WC Surgery SC Surgery GA CE2HQ UT WOS:000351636800003 PM 25565037 ER PT J AU Shunk, KA Zimmet, J Cason, B Speiser, B Tseng, EE AF Shunk, Kendrick A. Zimmet, Jeffrey Cason, Brian Speiser, Bernadette Tseng, Elaine E. TI Development of a Veterans Affairs Hybrid Operating Room for Transcatheter Aortic Valve Replacement in the Cardiac Catheterization Laboratory SO JAMA SURGERY LA English DT Article ID HIGH-RISK PATIENTS; IMPLANTATION; SURGERY; OUTCOMES; STENOSIS; MANAGEMENT; FACILITY; REGISTRY; PROGRAM AB IMPORTANCE Transcatheter aortic valve replacement (TAVR) revolutionized the treatment of aortic stenosis. Developing a TAVR program with a custom-built hybrid operating room (HOR) outside the surgical operating room area poses unique challenges in Veterans Affairs (VA) institutions. OBJECTIVE To present the process by which the San Francisco VA Medical Center developed a VA-approved TAVR program, in which an HOR exists in a cardiac catheterization laboratory, as a guideline for future programs. DESIGN, SETTING, AND PARTICIPANTS Retrospective review of each required approval process for developing an HOR in a cardiac catheterization laboratory in a VA designated for complex surgery. Participants included San Francisco VA Medical Center health care professionals and individuals responsible for new program initiation in VA institutions. EXPOSURES External reviews by industry vendors, the VA Central Office, and the Office for Construction, Facilities, and Management and an internal Healthcare Failure Mode and Effect Analysis. MAIN OUTCOMES AND MEASURES The timeline for each process. RESULTS Developing a TAVR program required vetting and approval from industry vendors, who provided training and expertise. Architectural plans for construction of the HOR began in 2010-2011, followed by approval from Edwards Lifesciences, Inc, in 2012 and fundamentals training on February 8 and 9, 2013. Following a pilot launch of the first VA TAVR program at the Houston VA Medical Center, subsequent programs were required to submit a plan to the VA Central Office for proposed restructuring of their clinical programs. After the San Francisco VA Medical Center proposal submission on February 3, 2013, a site visit consisting of a National Chief of Catheterization Laboratory Managers, a cardiac surgeon, and an interventional cardiologist with TAVR experience was conducted on April 12, 2013. During construction, HOR plans were inspected by the Office for Construction, Facilities, and Management followed by on-site inspection on August 8, 2013, to assess the adequacy of the HOR, newly built restricted corridors, equipment storage areas, and altered staff and patient flow patterns. Last, a Healthcare Failure Mode and Effect Analysis was performed to mitigate any negative effects of the HOR not being colocated in the surgical operating room area. Approval was then granted on November 13, 2013. Our first 10 TAVR cases were successfully completed as of April 2, 2014. CONCLUSIONS AND RELEVANCE The primary factor for development of a successful TAVR program is integration of the heart valve team. Particular adaptations to the cardiac catheterization laboratory environment are required to accommodate an uncompromised HOR in which cardiac and vascular surgeons can be as comfortable as their interventional cardiology colleagues. C1 [Shunk, Kendrick A.; Zimmet, Jeffrey] San Francisco VA Med Ctr, Div Cardiol, San Francisco, CA 94121 USA. [Cason, Brian] San Francisco VA Med Ctr, Dept Anesthesia, San Francisco, CA USA. [Speiser, Bernadette] Jesse Brown VA Med Ctr, Div Cardiol, Chicago, IL USA. [Tseng, Elaine E.] San Francisco VA Med Ctr, Div Cardiothorac Surg, San Francisco, CA USA. RP Tseng, EE (reprint author), UCSF Med Ctr, Div Cardiothorac Surg, 4150 Clement St,112D, San Francisco, CA 94121 USA. EM elaine.tseng@va.gov NR 22 TC 0 Z9 0 U1 1 U2 4 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6254 EI 2168-6262 J9 JAMA SURG JI JAMA Surg. PD MAR PY 2015 VL 150 IS 3 BP 216 EP 222 DI 10.1001/jamasurg.2014.1404 PG 7 WC Surgery SC Surgery GA CE2HQ UT WOS:000351636800007 PM 25588001 ER PT J AU Boudreaux-Kelly, M Wilson, M Bokhari, M AF Boudreaux-Kelly, Monique Wilson, Mark Bokhari, Malak TI Statistical Methods of Risk-Adjusted Statistical Process Control Charts to Assess Surgical Performance in Consecutive Colorectal Operations at a Single Institution SO JAMA SURGERY LA English DT Letter C1 [Boudreaux-Kelly, Monique] Res StatCore, Pittsburgh Res Off, Pittsburgh, PA USA. [Wilson, Mark; Bokhari, Malak] VA Pittsburgh Healthcare Syst, Dept Surg, Pittsburgh, PA 15240 USA. RP Bokhari, M (reprint author), VA Pittsburgh Healthcare Syst, Dept Surg, Univ Dr Campus 112 U, Pittsburgh, PA 15240 USA. EM malak.bokhari@va.gov NR 3 TC 0 Z9 0 U1 1 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6254 EI 2168-6262 J9 JAMA SURG JI JAMA Surg. PD MAR PY 2015 VL 150 IS 3 BP 271 EP 272 DI 10.1001/jamasurg.2014.1773 PG 2 WC Surgery SC Surgery GA CE2HQ UT WOS:000351636800016 PM 25606809 ER PT J AU Smith, ER Porter, KE Messina, MG Beyer, JA Defever, ME Foa, EB Rauch, SAM AF Smith, Erin R. Porter, Katherine E. Messina, Michael G. Beyer, Jonathan A. Defever, Mahrie E. Foa, Edna B. Rauch, Sheila A. M. TI Prolonged Exposure for PTSD in a Veteran group: A pilot effectiveness study SO JOURNAL OF ANXIETY DISORDERS LA English DT Article DE Prolonged Exposure therapy; Group psychotherapy; PTSD; Veterans ID POSTTRAUMATIC-STRESS-DISORDER; COGNITIVE-BEHAVIORAL THERAPY; RAPE VICTIMS; TRIAL AB Previous research has consistently demonstrated that Prolonged Exposure (PE) therapy is an effective treatment for posttraumatic stress disorder (PTSD). Traditionally, PE has been studied and delivered on an individual basis. However, the growing number of Veterans in need of PTSD treatment has led to increased interest in group therapies as an efficient way to provide access to care. The current study examined a group and individual hybrid treatment that was developed based on PE principles. Treatment was 12 weeks in length and consisted of 12 one-hour group sessions focused on in vivo exposures, and an average of approximately five-hour long individual imaginal exposure sessions. Data for this study were derived from 67 veterans who participated in 12 cohorts of the Group PE. Significant reductions in PTSD and depression symptoms were found in both completers and intent-to-treat sample analyses. The clinical implications of these findings are discussed. Published by Elsevier Ltd. C1 [Smith, Erin R.; Porter, Katherine E.; Rauch, Sheila A. M.] VA Ann Arbor Healthcare Syst, Mental Hlth Serv, Ann Arbor, MI 48105 USA. [Smith, Erin R.; Porter, Katherine E.; Rauch, Sheila A. M.] Univ Michigan, Sch Med, Dept Psychiat, Ann Arbor, MI USA. [Messina, Michael G.] William S Middleton Mem Vet Adm Med Ctr, Mental Hlth Serv, Madison, WI USA. [Messina, Michael G.] Univ Wisconsin, Dept Psychiat, Sch Med & Publ Hlth, Madison, WI 53706 USA. [Beyer, Jonathan A.] Jesse Brown VA Med Ctr, Mental Hlth Serv, Chicago, IL USA. [Foa, Edna B.] Univ Penn, Philadelphia, PA 19104 USA. RP Smith, ER (reprint author), VA Ann Arbor Healthcare Syst, 2215 Fuller Rd, Ann Arbor, MI 48105 USA. EM Erin.Smith3@va.gov RI Rauch, Sheila/K-4450-2015 OI Rauch, Sheila/0000-0001-9686-4011 FU CDA-2 Award from the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Clinical Sciences Research and Development FX Dr. Rauch's contribution was based upon work supported by a CDA-2 Award from the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Clinical Sciences Research and Development. NR 33 TC 5 Z9 5 U1 3 U2 12 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0887-6185 EI 1873-7897 J9 J ANXIETY DISORD JI J. Anxiety Disord. PD MAR PY 2015 VL 30 BP 23 EP 27 DI 10.1016/j.janxdis.2014.12.008 PG 5 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA CE2PX UT WOS:000351658600005 PM 25594370 ER PT J AU Loboprabhu, S Molinari, V Asghar-Ali, AA AF Loboprabhu, Sheila Molinari, Victor Asghar-Ali, Ali Abbas TI Castaways: Addressing Hostility and Helplessness in Severely Lonely Adults SO JOURNAL OF PSYCHIATRIC PRACTICE LA English DT Article DE hostility; helplessness; loneliness; validation; mentalization; reality orientation; socialization ID ATTACHMENT RELATIONSHIPS; LONELINESS; SELF; CHILDHOOD; PREDICTORS; CHILDREN; BEHAVIOR; TRAUMA; MODEL; LIFE AB Hostility and helplessness are recurrent themes in severely lonely adults, and they can be both causes and effects of subjective feelings of loneliness. Since many lonely patients report a history of abuse, hostile and helpless states of mind may reflect identification with hostile (aggressor) or helpless (passive) attachment figures. Hostile intrusiveness and helpless withdrawal by the parent are 2 distinct patterns of parent-child misattunement that can lead to infant disorganization via disrupted emotional communication and to loneliness later in life. Anxious-ambivalent lonely older adults tend to exhibit hyperactivating hostile behaviors (to deal with a core sense of powerlessness), whereas those with fearful-avoidant attachment styles exhibit deactivating helpless behaviors (to deflect intense underlying feelings of rage). Based on this model, we outline different treatment approaches for lonely persons with different attachment styles by describing the successful treatment of two severely lonely, suicidal veterans. We describe an approach to treating hostile and helpless behaviors in lonely patients, using validation, mentalization, reality orientation, and socialization. Validation provides a sense of safety and rapport. Mentalization allows the lonely individual to better appreciate his or her own mental processes and those of others. Reality orientation provides feedback to lonely individuals on whether their perceptions are accurate and reality-based and helps them appreciate the consequences their behavior may have for self and others. Finally, socialization reduces disenfranchisement by teaching/re-teaching individuals social skills that may have become impaired by prolonged isolation. C1 [Loboprabhu, Sheila; Asghar-Ali, Ali Abbas] Michael E DeBakey Dept Vet Affairs Med Ctr, Houston, TX USA. [Loboprabhu, Sheila; Asghar-Ali, Ali Abbas] Baylor Coll Med, Houston, TX 77030 USA. [Molinari, Victor] Univ S Florida, Tampa, FL USA. RP Loboprabhu, S (reprint author), Michael E DeBakey Dept Vet Affairs Med Ctr, Mental Hlth Care Line, 2002 Holcombe Blvd, Houston, TX 77030 USA. EM SheilaM.Loboprabhu@va.gov NR 45 TC 0 Z9 0 U1 2 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1527-4160 EI 1538-1145 J9 J PSYCHIATR PRACT JI J. Psychiatr. Pract. PD MAR PY 2015 VL 21 IS 2 BP 93 EP 106 DI 10.1097/01.pra.0000462602.94853.2f PG 14 WC Psychiatry SC Psychiatry GA CE2TR UT WOS:000351672100002 PM 25782760 ER PT J AU Enguidanos, S Kogan, AMC Schreibeis-Baum, H Lendon, J Lorenz, K AF Enguidanos, Susan Kogan, Alexis M. Coulourides Schreibeis-Baum, Hannah Lendon, Jessica Lorenz, Karl TI "Because I Was Sick": Seriously Ill Veterans' Perspectives on Reason for 30-Day Readmissions SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Article DE readmission; seriously ill; cancer; heart failure; palliative care ID HOSPITAL READMISSION; PALLIATIVE CARE; MEDICARE BENEFICIARIES; COST AB ObjectivesTo determine the perspectives of seriously ill individuals on reasons for 30-day hospital readmission. DesignA prospective qualitative study was conducted employing individual interviews conducted at bedside. SettingDepartment of Veterans Affairs Greater Los Angeles Healthcare System. ParticipantsSeriously ill individuals with heart failure or cancer receiving inpatient palliative care and readmitted to the hospital within 30days of hospital discharge were recruited to participate. Nine were interviewed. MeasurementsA semistructured interview protocol was used to elicit participant perspectives on readmission causes. ResultsAll participants were male and had a mean age of 70.19.5. Participants were ethnically diverse (three African Americans, three Caucasians, three Hispanic or mixed ethnic background). Six lived alone, and four did not have caregiver support. Qualitative analysis of transcripts revealed three themes relating to reasons for hospital readmission: lack of caregiver support and motivation to provide self-care, acceptance of condition and desire for aggressive care, and access to care and poor quality of care. ConclusionParticipants identified potentially avoidable reasons for hospital readmission as well as causes that require rethinking regarding how community support is targeted and delivered. Participant preference for aggressive care, inability to provide self-care, and lack of caregiver support suggest the need for new and innovative mechanisms to support seriously ill community-dwelling individuals. C1 [Enguidanos, Susan; Kogan, Alexis M. Coulourides] Univ So Calif, Leonard Davis Sch Gerontol, Los Angeles, CA 90089 USA. [Schreibeis-Baum, Hannah; Lendon, Jessica; Lorenz, Karl] US Dept Vet Affairs, Los Angeles, CA USA. RP Enguidanos, S (reprint author), Univ So Calif, Davis Sch Gerontol, 3715 McClintock Ave, Los Angeles, CA 90089 USA. EM Susan.Enguidanos@usc.edu OI Enguidanos, Susan/0000-0002-5112-288X FU National Palliative Care Research Center FX This study was supported by a career development award from the National Palliative Care Research Center. Hannah Schreibeis-Baum, Jessica Lendon, and Karl Lorenz are employed by the VA, the site of the research study. Susan Enguidanos and Alexis Coulourides Kogan received grant funds from the National Palliative Care Research Center to conduct this research. NR 26 TC 2 Z9 2 U1 1 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-8614 EI 1532-5415 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD MAR PY 2015 VL 63 IS 3 BP 537 EP 542 DI 10.1111/jgs.13238 PG 6 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA CE3PO UT WOS:000351740400015 PM 25732270 ER PT J AU Dawes, AJ Sacks, GD Cryer, HG Gruen, JP Preston, C Gorospe, D Cohen, M McArthur, DL Russell, MM Maggard-Gibbons, M Ko, CY AF Dawes, Aaron J. Sacks, Greg D. Cryer, H. Gill Gruen, J. Peter Preston, Christy Gorospe, Deidre Cohen, Marilyn McArthur, David L. Russell, Marcia M. Maggard-Gibbons, Melinda Ko, Clifford Y. CA Los Angeles Cty Trauma Consortium TI Intracranial pressure monitoring and inpatient mortality in severe traumatic brain injury: A propensity score-matched analysis SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article; Proceedings Paper CT 73rd Annual Meeting of the American-Association-for-the-Surgery-of-Trauma / Clinical Congress of Acute Care Surgery CY SEP 09-13, 2014 CL Philadelphia, PA SP Amer Assoc Surg Trauma DE Traumatic brain injury; intracranial pressure monitoring; mortality; propensity score ID SEVERE HEAD-INJURY; EVIDENCE-BASED GUIDELINES; UNITED-STATES; CARE; HOSPITALIZATION; IMPROVEMENT; MANAGEMENT; OUTCOMES; CENTERS AB BACKGROUND: Although intracranial pressure (ICP) monitoring in severe traumatic brain injury (TBI) is recommended by the Brain Trauma Foundation, the benefits remain controversial. We sought to determine the impact of ICP monitor placement on inpatient mortality within a regional trauma system after correcting for selection bias through propensity score matching. METHODS: Data were collected on all severe TBI cases presenting to 14 trauma centers during the 2-year study period (2009-2010). Inclusion criteria were as follows: blunt injury, Glasgow Coma Scale (GCS) score of 8 or lower in the emergency department, and abnormal intracranial findings on head computed tomography (CT). Two separate multivariate logistic regression models were used to predict ICP monitor placement and inpatient mortality after controlling for demographics, severity of injury, comorbidities, and TBI-specific variables (GCS score, pupil reactivity, international normalized ratio, and nine specific head CT findings). To account for selection bias, we developed a propensity score-matched model to estimate the "true'' effect of ICP monitoring on in-hospital mortality. RESULT: A total of 844 patients met inclusion criteria; 22 died on arrival to the emergency department. Inpatient mortality was 38.8%; 46.0% of the patients underwent ICP monitor placement. Unadjusted mortality rates were significantly lower in the ICP monitoring group (30.7% vs. 45.7%, p < 0.001). ICP monitor placement was positively associated with CT findings of subdural hematoma, intraparenchymal contusion, and mass effect and negatively associated with age, alcoholism, and elevated international normalized ratio. After adjusting for selection bias via propensity score matching, ICP monitor placement was associated with an 8.3 percentage point reduction in the risk-adjusted mortality rate. CONCLUSION: ICP monitor placement occurred in only 46% of eligible patients but was associated with significantly decreased mortality after adjusting for baseline risk profile and the propensity to undergo monitoring. As the individual impact of ICP monitoring may vary, future efforts must determine who stands to benefit from invasive monitoring techniques. (Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.) C1 [Dawes, Aaron J.; Sacks, Greg D.; Cryer, H. Gill; Cohen, Marilyn; Russell, Marcia M.; Maggard-Gibbons, Melinda; Ko, Clifford Y.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Surg, Los Angeles, CA 90095 USA. [McArthur, David L.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurosurg, Los Angeles, CA 90095 USA. [Dawes, Aaron J.; Sacks, Greg D.] Univ Calif Los Angeles, Robert Wood Johnson Clin Scholars Program, Los Angeles, CA USA. [Dawes, Aaron J.; Russell, Marcia M.; Maggard-Gibbons, Melinda; Ko, Clifford Y.] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. [Gruen, J. Peter] Univ So Calif, Dept Neurosurg, Los Angeles, CA USA. [Preston, Christy; Gorospe, Deidre] Cty Los Angeles, Dept Hlth Serv, Emergency Med Serv Agcy, Los Angeles, CA USA. RP Dawes, AJ (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Dept Surg, Ronald Reagan UCLA Med Ctr, 757 Westwood Plaza B7-11, Los Angeles, CA 90095 USA. EM adawes@mednet.ucla.edu OI Dawes, Aaron/0000-0003-4574-6765 FU VA Office of Academic Affiliations through the VA/Robert Wood Johnson Clinical Scholars Program FX A.J.D. was supported by the VA Office of Academic Affiliations through the VA/Robert Wood Johnson Clinical Scholars Program. NR 24 TC 11 Z9 11 U1 1 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD MAR PY 2015 VL 78 IS 3 BP 492 EP 501 DI 10.1097/TA.0000000000000559 PG 10 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA CE8DQ UT WOS:000352072000011 PM 25710418 ER PT J AU Brawner, BM Reason, JL Goodman, BA Schensul, JJ Guthrie, B AF Brawner, Bridgette M. Reason, Janaiya L. Goodman, Bridget A. Schensul, Jean J. Guthrie, Barbara TI Multilevel Drivers of Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome Among Black Philadelphians Exploration Using Community Ethnography and Geographic Information Systems SO NURSING RESEARCH LA English DT Article DE ethnography; geographic mapping; HIV; public health ID SEXUALLY-TRANSMITTED-DISEASES; AFRICAN-AMERICAN WOMEN; HIV RISK; NEIGHBORHOOD CONTEXT; UNITED-STATES; HEALTH; BEHAVIORS; HIV/AIDS; PREVENTION; MEN AB Background: Unequal human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) distribution is influenced by certain social and structural contexts that facilitate HIV transmission and concentrate HIV in disease epicenters. Thus, one of the first steps in designing effective community-level HIV/AIDS initiatives is to disentangle the influence of individual, social, and structural factors on HIV risk. Combining ethnographic methodology with geographic information systems mapping can allow for a complex exploration of multilevel factors within communities that facilitate HIV transmission in highly affected areas. Objectives: We present the formative comparative community-based case study findings of an investigation of individual-, social-, and structural-level factors that contribute to the HIV/AIDS epidemic among Black Philadelphians. Methods: Communities were defined using census tracts. The methodology included ethnographic and geographic information systems mapping, observation, informal conversations with residents and business owners, and secondary analyses of census tract-level data in four Philadelphia neighborhoods. Results: Factors such as overcrowding, disadvantage, permeability in community boundaries, and availability and accessibility of health-related resources varied significantly. Furthermore, HIV/AIDS trended with social and structural inequities above and beyond the community's racial composition. Discussion: This study was a first step to disentangle relationships between community-level factors and potential risk for HIV in an HIV epicenter. The findings also highlight stark sociodemographic differences within and across racial groups and further substantiate the need for comprehensive, community-level HIV prevention interventions. These findings from targeted U.S. urban communities have potential applicability for examining the distribution of HIV/AIDS in broader national and international geosocial contexts. C1 [Brawner, Bridgette M.] Univ Penn, Sch Nursing, Ctr Hlth Equ Res, Ctr Global Womens Hlth,Nursing, Philadelphia, PA 19104 USA. [Brawner, Bridgette M.; Reason, Janaiya L.] Univ Penn, Sch Nursing, Ctr Hlth Equ Res, Ctr Global Womens Hlth, Philadelphia, PA 19104 USA. [Goodman, Bridget A.] Nazarbayev Univ, Grad Sch Educ, Astana, Kazakhstan. [Schensul, Jean J.] Inst Community Res, Hartford, CT USA. [Guthrie, Barbara] Northeastern Univ, Nursing PhD Program, Boston, MA 02115 USA. RP Brawner, BM (reprint author), Univ Penn, Sch Nursing, Ctr Hlth Equ Res, Ctr Global Womens Hlth, 418 Curie Blvd,4th Floor,Room 419, Philadelphia, PA 19104 USA. EM brawnerb@nursing.upenn.edu FU National Institute of Mental Health [R25MH087217] FX The authors acknowledge that this study was funded by pilot funding awarded to Dr. Brawner through the National Institute of Mental Health R25MH087217 (Guthrie, Schensul, and Singer [PIs]). NR 53 TC 2 Z9 2 U1 3 U2 15 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0029-6562 EI 1538-9847 J9 NURS RES JI Nurs. Res. PD MAR-APR PY 2015 VL 64 IS 2 BP 100 EP 110 DI 10.1097/NNR.0000000000000076 PG 11 WC Nursing SC Nursing GA CE2GS UT WOS:000351633500372 PM 25738621 ER PT J AU Lawrence, LA Mulligan, JK Roach, C Pasquini, WN Soler, ZM Banglawala, SM Karnezis, TT Gudis, DA Schlosser, RJ AF Lawrence, Lauren A. Mulligan, Jennifer K. Roach, Catherine Pasquini, Whitney N. Soler, Zachary M. Banglawala, Sarfaraz M. Karnezis, Tom T. Gudis, David A. Schlosser, Rodney J. TI Superoxide dismutase reduces the inflammatory response to Aspergillus and Alternaria in human sinonasal epithelial cells derived from patients with chronic rhinosinusitis SO AMERICAN JOURNAL OF RHINOLOGY & ALLERGY LA English DT Article ID EOSINOPHILIC CHRONIC RHINOSINUSITIS; NASAL POLYPS; IN-VITRO; AIRWAY EPITHELIUM; OXIDATIVE STRESS; AIRBORNE FUNGI; EXPRESSION; ASTHMA; FUMIGATUS; ANTIOXIDANTS AB Background: Aspergillus fumigatus and Alternaria alternata are ubiquitous environmental fungal allergens that can exacerbate airway inflammation and contribute to the disease process in patients with chronic rhinosinusitis (CRS). These antigens have been shown to induce human sinonasal epithelial cells (HSNECs) to promote a proinflammatory response, but what is unclear is a means by which to reduce these effects. Inhaled pathogens can induce HSNECs to produce reactive oxygen species (ROS) that trigger cytokine production. Objective: This study aimed to determine whether the free radical scavenger superoxide dismutase (SOD) could reduce HSNEC-derived inflammation, as measured by interleukin (IL)-6 and IL-8 production, in response to Aspergillus or Alternaria exposure. Methods: Sinus tissue explants were collected at the time of surgery from control patients (n = 7) and patients with CRS with nasal polyps (CRSwNP) (n = 9). HSNECs were cultured from the explants and treated with Aspergillus, Alternaria, and SOD for 24 hours. Cell supernatants and lysates were collected, and IL-6 and IL-8 concentrations were measured using enzyme-linked immunosorbent assay. Results: In control and CRSwNP HSNECs, Aspergillus and Alternaria both increased cytokine production (p < 0.05), as measured by IL-6 and IL-8 concentration. SOD treatment reduced the inflammatory response to fungal antigen exposure from CRSwNP HSNECs but not control HSNECs. In CRSwNP patients, SOD significantly decreased IL-6 and IL-8 production after Alternaria exposure and IL-8 after Aspergillus exposure (p < 0.05). Conclusions: When HSNECs from CRSwNP patients are treated with SOD concurrently with Aspergillus or Alternaria, SOD treatment decreases the fungal antigen-induced inflammatory response. The ability to attenuate inflammation induced by common fungal allergens with SOD treatment could provide a novel therapeutic or preventative approach for patients with CRS or other allergic inflammatory airway diseases. C1 [Lawrence, Lauren A.; Mulligan, Jennifer K.; Roach, Catherine; Pasquini, Whitney N.; Soler, Zachary M.; Banglawala, Sarfaraz M.; Karnezis, Tom T.; Gudis, David A.; Schlosser, Rodney J.] Med Univ S Carolina, Dept Otolaryngol Head & Neck Surg, Charleston, SC 29425 USA. [Mulligan, Jennifer K.] Med Univ S Carolina, Dept Pediat, Charleston, SC 29425 USA. [Mulligan, Jennifer K.; Schlosser, Rodney J.] Ralph H Johnson Vet Affairs Med Ctr, Charleston, SC USA. RP Lawrence, LA (reprint author), Med Univ S Carolina, Dept Otolaryngol Head & Neck Surg, 135 Rutledge,MSC-550, Charleston, SC 29425 USA. EM lawre194@gmail.com FU Department of Veterans Affairs, Veterans Health Administration, Clinical Sciences Research and Development Merit Award; CSRD [1I01CX000377-01A2]; Optinose; Intersect ENT; Flight Attendant Medical Research Institute [092401] FX This work was supported by the Department of Veterans Affairs, Veterans Health Administration, Clinical Sciences Research and Development Merit Award, and the CSRD Grant 1I01CX000377- 01A2. This material is the result of work supported with resources and the use of facilities at the Ralph H. Johnson VA Medical Center, Charleston, South Carolina; R J Schlosser is a consultant for BrainLAB Inc. and Olympus and has been provided grant support from Optinose and Intersect ENT; none of these provided support for this investigation. Z M Soler is also consultant for BrainLAB Inc., but no support was provided for this investigation. J K Mulligan is funded by a grant from the Flight Attendant Medical Research Institute (ID, 092401), which was not affiliated with this investigation. The remaining authors have no conflicts of interest pertaining to this article NR 41 TC 1 Z9 1 U1 1 U2 2 PU OCEAN SIDE PUBLICATIONS INC PI PROVIDENCE PA 95 PITMAN ST, PROVIDENCE, RI 02906 USA SN 1945-8924 EI 1945-8932 J9 AM J RHINOL ALLERGY JI Am. J. Rhinol. Allergy PD MAR-APR PY 2015 VL 29 IS 2 BP 89 EP 93 DI 10.2500/ajra.2015.29.4155 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA CE3HL UT WOS:000351717200007 PM 25785747 ER PT J AU Stappenbeck, CA Luterek, JA Kaysen, D Rosenthal, CF Gurrad, B Simpson, TL AF Stappenbeck, Cynthia A. Luterek, Jane A. Kaysen, Debra Rosenthal, Christina F. Gurrad, Bethann Simpson, Tracy L. TI A controlled examination of two coping skills for daily alcohol use and PTSD symptom severity among dually diagnosed individuals SO BEHAVIOUR RESEARCH AND THERAPY LA English DT Article DE Coping behavior; Posttraumatic stress disorder; Alcohol dependence; Dual diagnosis; Cognitive restructuring; Experiential acceptance ID POSTTRAUMATIC-STRESS-DISORDER; SUBSTANCE USE DISORDERS; CONFIRMATORY FACTOR-ANALYSIS; RELAPSE PREVENTION; THOUGHT SUPPRESSION; COCAINE ABUSE; USE OUTCOMES; DEPENDENCE; THERAPY; EXPOSURE AB Investigations of targeted coping skills could help guide initial treatment decisions for individuals with co-occurring posttraumatic stress disorder (PTSD) and alcohol dependence (AD) who often endorse worse coping skills than those with AD but not PTSD. Although improvement in coping skills is associated with enhanced alcohol use outcomes, no study has evaluated the utility of teaching specific coping skills in the context of comorbid PTSD/AD. We compared the effects of teaching two coping skills (cognitive restructuring [CR] and experiential acceptance [EA]) or an attention control condition on drinking and PTSD symptoms among 78 men and women with comorbid PTSD/AD during a 5-week daily follow-up assessment. Both CR and EA skills were associated with decreased drinking compared to control, and that change in drinking over time did not significantly differ between those who received CR and EA. Individuals who received CR skills, however, consumed less alcohol on a given day than those who received EA skills. Neither CR nor EA was associated with a decrease in PTSD symptom severity. These results provide preliminary support for clinicians to prioritize CR and EA skills during initial treatment sessions when working with individuals with PTSD/AD, and offer ideas for continued investigation and intervention refinement. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Stappenbeck, Cynthia A.; Kaysen, Debra; Simpson, Tracy L.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98105 USA. [Luterek, Jane A.; Rosenthal, Christina F.; Gurrad, Bethann; Simpson, Tracy L.] VA Puget Sound Hlth Care Syst, Seattle, WA USA. RP Stappenbeck, CA (reprint author), Univ Washington, Box 354944, Seattle, WA 98105 USA. EM cstappen@uw.edu FU NIH/NIAAA [R21AA17130] FX This study was supported in part by a grant from NIH/NIAAA (R21AA17130; PI: Simpson) as well as by resources from the Center of Excellence in Substance Abuse Treatment and Education (CESATE) at the VA Puget Sound Health Care System. NR 63 TC 4 Z9 4 U1 2 U2 23 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0005-7967 EI 1873-622X J9 BEHAV RES THER JI Behav. Res. Ther. PD MAR PY 2015 VL 66 BP 8 EP 17 DI 10.1016/j.brat.2014.12.013 PG 10 WC Psychology, Clinical SC Psychology GA CD7CU UT WOS:000351249200002 PM 25617814 ER PT J AU Hermayer, KL Loftley, AS Reddy, S Narla, SN Epps, NA Zhu, YS AF Hermayer, Kathie L. Loftley, Aundrea S. Reddy, Sumana Narla, Satya Nandana Epps, Nina A. Zhu, Yusheng TI Challenges of Inpatient Blood Glucose Monitoring: Standards, Methods, and Devices to Measure Blood Glucose SO CURRENT DIABETES REPORTS LA English DT Article DE Glucose; Meter; Point of care; Hyperglycemia; Hypoglycemia; Hospital; Arterial; Venous; Capillary; i-Stat; HemoCue; YSI; Critical illness; Calibration; Continuous glucose monitoring; Maltose; Wired; Wireless; FDA; CLIA ID INTENSIVE INSULIN THERAPY; CRITICALLY-ILL PATIENTS; HEMATOCRIT; CARE; MANAGEMENT; ACCURACY; METERS; HYPERGLYCEMIA; CAPILLARY; ARTERIAL AB Glucose control in the hospital setting is very important. There is a high incidence of hyperglycemia, hypoglycemia, and glycemic variability in hospitalized patients. Safe insulin delivery and glucose control is dependent on reliable glucose meters and monitoring systems in the hospital. Different glucose monitoring systems use arterial, venous, central venous, and capillary blood samples. It is important for clinicians to be aware that there are limitations of specific point-of-care (POC) glucose meters and that situations exist whereby POC glucose meters as the sole measurement device should be avoided. POC meter devices are not approved by the Food and Drug Administration for use in critical care, although POC meter devices are commonly used in critical care settings and elsewhere. This review focuses on glucose assay principles, instrument technology, influences on glucose measurement, standards for glucose measurement, and an evaluation of different methods to measure blood glucose in the hospital setting. C1 [Hermayer, Kathie L.; Loftley, Aundrea S.; Reddy, Sumana] Med Univ S Carolina, Div Endocrinol Diabet & Med Genet, Charleston, SC 29425 USA. [Hermayer, Kathie L.] Ralph H Johnson Vet Affairs Med Ctr, Charleston, SC 29401 USA. [Narla, Satya Nandana; Zhu, Yusheng] Med Univ S Carolina, Dept Pathol & Lab Med, Charleston, SC 29425 USA. [Epps, Nina A.] Med Univ S Carolina, Lab Serv Point Care Testing Qual & Safety, Charleston, SC 29425 USA. RP Hermayer, KL (reprint author), Med Univ S Carolina, Div Endocrinol Diabet & Med Genet, 96 Jonathan Lucas St,MSC 624, Charleston, SC 29425 USA. EM hermayer@musc.edu; easona@musc.edu; reddysu@musc.edu; narlas@musc.edu; eppsn@musc.edu; zhuyu@musc.edu NR 38 TC 3 Z9 3 U1 4 U2 22 PU CURRENT MEDICINE GROUP PI PHILADELPHIA PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA SN 1534-4827 EI 1539-0829 J9 CURR DIABETES REP JI Curr. Diabetes Rep. PD MAR PY 2015 VL 15 IS 3 AR 10 DI 10.1007/s11892-015-0582-9 PG 10 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA CD6WZ UT WOS:000351232400001 PM 25644818 ER PT J AU Chen, HM Fujita, M AF Chen, Hui-min Fujita, Mayumi TI IL-37: A new player in immune tolerance SO CYTOKINE LA English DT Editorial Material ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; ADAPTIVE IMMUNITY; DENDRITIC CELLS; INTERLEUKIN 37; EXPRESSION; INNATE; DISEASE; PROTECTS; OBESITY; MEMBERS C1 [Chen, Hui-min; Fujita, Mayumi] Univ Colorado, Dept Dermatol, Aurora, CO 80045 USA. [Fujita, Mayumi] Denver Vet Affairs Med Ctr, Denver, CO 80220 USA. RP Fujita, M (reprint author), Univ Colorado, Dept Dermatol, Anschutz Med Campus, Aurora, CO 80045 USA. EM Mayumi.Fujita@ucdenver.edu FU NIAMS NIH HHS [P30AR057212] NR 27 TC 9 Z9 10 U1 1 U2 5 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 1043-4666 EI 1096-0023 J9 CYTOKINE JI Cytokine PD MAR PY 2015 VL 72 IS 1 BP 113 EP 114 DI 10.1016/j.cyto.2014.11.025 PG 2 WC Biochemistry & Molecular Biology; Cell Biology; Immunology SC Biochemistry & Molecular Biology; Cell Biology; Immunology GA CD8CI UT WOS:000351322400017 PM 25592113 ER PT J AU Parsons, EC Hough, CL Vitiello, MV Zatzick, D Davydow, DS AF Parsons, Elizabeth C. Hough, Catherine L. Vitiello, Michael V. Zatzick, Douglas Davydow, Dimitry S. TI Insomnia is associated with quality of life impairment in medical-surgical intensive care unit survivors SO HEART & LUNG LA English DT Article DE Insomnia; Post-traumatic stress disorder; Depression; Critical care; Intensive care; Outcome assessment ID MAJOR DEPRESSIVE DISORDER; COGNITIVE-BEHAVIORAL THERAPY; CRITICALLY ILL PATIENTS; POSTTRAUMATIC-STRESS; SEVERITY INDEX; SLEEP; VALIDATION; SYMPTOMS; MULTICENTER; MORBIDITY AB Objectives: To examine the prevalence of insomnia and its relationship to health-related quality of life (HRQOL) post-intensive care unit (ICU). Background: The burden of post-ICU insomnia is unknown. Methods: This cross-sectional study examined data from 120 patients with an ICU stay >24 h. Prehospital health was assessed in-hospital. Insomnia, HRQOL and post-ICU psychiatric symptoms were assessed at 12 months post-ICU. Results: Over one-quarter (28%) of subjects met insomnia criteria at 12 months post-ICU. Post-ICU insomnia was independently associated with worse mental HRQOL (P < 0.01), as well as worse scores on the HRQOL sub-domains of bodily pain (P < 0.001), vitality (P < 0.05) and physical function (P < 0.05). However, these associations were no longer significant after adjusting for post-ICU psychiatric symptoms (P = 033). Conclusions: Insomnia is common among ICU survivors. Post-ICU insomnia is significantly associated with mental HRQOL and could identify ICU survivors who may benefit from further psychiatric evaluation. Published by Elsevier Inc. C1 [Parsons, Elizabeth C.] VA Puget Sound Hlth Care Syst, Seattle, WA 98108 USA. [Parsons, Elizabeth C.; Hough, Catherine L.] Univ Washington, Div Pulm & Crit Care Med, Seattle, WA 98195 USA. [Vitiello, Michael V.; Zatzick, Douglas; Davydow, Dimitry S.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. RP Parsons, EC (reprint author), VA Puget Sound Hlth Care Syst, Seattle, WA 98108 USA. EM elizabeth.parsons@va.gov FU National Institutes of Health [KL2 TR000421, NRSA-T32/MH20021-12, R03 AA020146-02, K24 MH086814-03]; University of Washington Alcohol and Drug Abuse Institute [ADAI-1009-2] FX This work was performed at Harborview Medical Center, supported by grants KL2 TR000421, NRSA-T32/MH20021-12, R03 AA020146-02, and K24 MH086814-03 from the National Institutes of Health and grant ADAI-1009-2 from the University of Washington Alcohol and Drug Abuse Institute. The views expressed here are those of the authors and do not reflect the position or policy of the Department of Veterans Affairs. NR 39 TC 3 Z9 4 U1 3 U2 9 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0147-9563 EI 1527-3288 J9 HEART LUNG JI Heart Lung PD MAR-APR PY 2015 VL 44 IS 2 BP 89 EP 94 DI 10.1016/j.hrting.2014.11.002 PG 6 WC Cardiac & Cardiovascular Systems; Nursing; Respiratory System SC Cardiovascular System & Cardiology; Nursing; Respiratory System GA CD4BK UT WOS:000351027400003 PM 25592203 ER PT J AU Bottche, M Pietrzak, RH Kuwert, P Knaevelsrud, C AF Boettche, Maria Pietrzak, Robert H. Kuwert, Philipp Knaevelsrud, Christine TI Typologies of posttraumatic stress disorder in treatment-seeking older adults SO INTERNATIONAL PSYCHOGERIATRICS LA English DT Article DE latent profile analysis; typology; older adults; early-life traumatization; PTSD ID CONFIRMATORY FACTOR-ANALYSIS; COMORBIDITY SURVEY REPLICATION; LATENT CLASS ANALYSIS; HOLOCAUST SURVIVORS; PTSD CHECKLIST; SYMPTOMS; VETERANS; NUMBER; SCALE AB Background: While it is well known that posttraumatic stress disorder (PTSD) is characterized by heterogeneous symptom clusters, little is known about predominant typologies of PTSD symptoms in older adults. Methods: Latent profile analyses (LPAs) were employed to evaluate predominant typologies of PTSD symptoms in a sample of 164 treatment-seeking older adults with childhood war-related trauma. Multinomial logistic regressions were conducted to evaluate predictors of class membership. Results: LPAs revealed that a 3-class solution best fit the data. These included an Intermediate Disturbance class (50.0%) and two Pervasive Disturbance classes, which differed with respect to severity of avoidance symptoms (Pervasive Disturbance-Low Avoidance: 33.5%, Pervasive Disturbance-High Avoidance: 16.5%). A greater number of traumatic events predicted membership in the Pervasive Disturbance classes. The Pervasive Disturbance-Low Avoidance class had a higher level of education than the Pervasive Disturbance-High Avoidance class. Compared to the Intermediate Disturbance class, the Pervasive Disturbance classes had the highest levels of depression, anxiety and somatization symptoms. Conclusion: These results suggest that PTSD in treatment-seeking older adults may be characterized by three predominant typologies, which are differentiated by overall severity and avoidance symptoms, lifetime trauma burden, education level, and comorbid depression, anxiety, and somatization symptoms. These results underscore the importance of considering heterogeneity in the phenotypic presentation of PTSD in assessment and treatment approaches for this disorder in older adults. C1 [Boettche, Maria; Knaevelsrud, Christine] Berlin Ctr Torture Victims, Berlin, Germany. [Boettche, Maria; Knaevelsrud, Christine] Free Univ Berlin, Dept Clin Psychol & Psychotherapy, Berlin, Germany. [Pietrzak, Robert H.] VA Connecticut Healthcare Syst, US Dept Vet Affairs, Natl Ctr Posttraumat Stress Disorder, West Haven, CT USA. [Pietrzak, Robert H.] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA. [Kuwert, Philipp] Ernst Moritz Arndt Univ Greifswald, Dept Psychiat & Psychotherapy, HELIOS Hansehosp Stralsund, Greifswald, Germany. RP Bottche, M (reprint author), Treatment Ctr Torture Victims, Turmstr 21, D-10559 Berlin, Germany. EM m.boettche@bzfo.de NR 31 TC 2 Z9 2 U1 1 U2 5 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1041-6102 EI 1741-203X J9 INT PSYCHOGERIATR JI Int. Psychogeriatr. PD MAR PY 2015 VL 27 IS 3 BP 501 EP 509 DI 10.1017/S1041610214002026 PG 9 WC Psychology, Clinical; Geriatrics & Gerontology; Gerontology; Psychiatry; Psychology SC Psychology; Geriatrics & Gerontology; Psychiatry GA CD4MM UT WOS:000351057100016 PM 25234418 ER PT J AU Rumsfeld, JS Holmes, DR Stough, WG Edwards, FH Jacques, LB Mack, MJ AF Rumsfeld, John S. Holmes, David R. Stough, Wendy Gattis Edwards, Fred H. Jacques, Louis B. Mack, Michael J. TI Insights From the Early Experience of the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry SO JACC-CARDIOVASCULAR INTERVENTIONS LA English DT Article DE Centers for Medicare and Medicaid Services (US); heart valve prosthesis implantation; investigational device exemption; National Cardiovascular Data Registry; registries; transcatheter aortic valve replacement; US Food and Drug Administration ID INFRASTRUCTURE; SURVEILLANCE AB The current system for postmarket surveillance of medical devices in the United States is limited. To help change this paradigm for transcatheter valve therapies (TVTs), starting with transcatheter aortic valve replacement, the Society of Thoracic Surgeons and the American College of Cardiology partnered to form the TVT Registry program in close collaboration with the U.S. Food and Drug Administration and the Center for Medicare and Medicaid Services. The goal of the TVT Registry is to measure and improve quality of care and patient outcomes in clinical practice and to have a pivotal role in the scientific evidence and surveillance for medical devices. Challenges were faced in the early experience of the registry included developing multistakeholder partnerships, data collection requirements, and the use of the registry for pre- and post-market device evaluations. In addressing these challenges, the TVT Registry demonstrates that it is feasible for professional societies to assume a pivotal role in pre- and/or post-market studies, leveraging a clinical registry infrastructure. Sharing the TVT Registry experience may help other professional societies and stakeholders better anticipate and plan for these challenges. (C) 2015 by the American College of Cardiology Foundation. C1 [Rumsfeld, John S.] Denver VA Med Ctr, Denver, CO 80220 USA. [Holmes, David R.] Mayo Clin, Div Cardiovasc Dis, Rochester, MN USA. [Stough, Wendy Gattis] Campbell Univ, Coll Pharm & Hlth Sci, Buies Creek, NC 27506 USA. [Edwards, Fred H.] Univ Florida, Hlth Sci Ctr, Jacksonville, FL 32209 USA. [Jacques, Louis B.] Ctr Medicare & Medicaid Serv, Baltimore, MD USA. [Mack, Michael J.] Heart Hosp Baylor, Baylor Healthcare Syst, Dallas, TX USA. RP Rumsfeld, JS (reprint author), Denver VA Med Ctr, Cardiol 111B, 1055 Clermont St, Denver, CO 80220 USA. EM john.rumsfeld@va.gov RI Stough, Wendy/R-4287-2016 OI Stough, Wendy/0000-0001-8290-1205 NR 7 TC 9 Z9 9 U1 1 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1936-8798 EI 1876-7605 J9 JACC-CARDIOVASC INTE JI JACC-Cardiovasc. Interv. PD MAR PY 2015 VL 8 IS 3 BP 377 EP 381 DI 10.1016/j.jcin.2014.09.022 PG 5 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA CD6TC UT WOS:000351221300007 PM 25703888 ER PT J AU Doty, RL Nsoesie, MT Chung, IN Osman, A Pawasarat, I Caulfield, J Hurtig, H Silas, J Dubroff, J Duda, JE Ying, GS Tekeli, H Leon-Sarmiento, FE AF Doty, Richard L. Nsoesie, Michael T. Chung, Inna Osman, Allen Pawasarat, Ian Caulfield, Julie Hurtig, Howard Silas, Jonathan Dubroff, Jacob Duda, John E. Ying, Gui-Shuang Tekeli, Hakan Leon-Sarmiento, Fidias E. TI Taste function in early stage treated and untreated Parkinson's disease SO JOURNAL OF NEUROLOGY LA English DT Article DE Parkinson's disease; Taste; Tongue; Dopamine; SPECT imaging; Cranial nerves ID OLFACTORY DYSFUNCTION; BRAIN-STEM; RECEPTORS; RESPONSES; SMELL AB Since brain stem regions associated with early Parkinson's disease (PD) pathology encroach upon those involved in taste function, the ability to taste may be compromised in PD. However, studies on this point have been contradictory. We administered well-validated whole-mouth and regional taste tests that incorporated multiple concentrations of sucrose, citric acid, caffeine, and sodium chloride to 29 early stage PD patients and 29 age-, sex-, and race-matched controls. Electrogustometry was also performed on the anterior tongue. The PD cohort was tested both on and off dopamine-related medications in counterbalanced test sessions. While whole-mouth taste identification test scores for all stimuli were, on average, nominally lower for the PD patients than for the controls, a trend in the opposite direction was noted for the intensity ratings at the lower stimulus concentrations for all stimuli except caffeine. Moreover, regional testing found that PD subjects tended to rate the stimuli, relative to the controls, as more intense on the anterior tongue and less intense on the posterior tongue. No significant associations were evident between taste test scores and UPDRS scores, L-DOPA medication equivalency values, or [Tc-99m]TRODAT-1 SPECT imaging of dopamine transporter uptake within the striatum and associated regions. Our findings suggest that suprathreshold measures of taste function are influenced by PD and that this disease differentially influences taste function on anterior (CN VII) and posterior (CN IX) tongue regions. Conceivably PD-related damage to CN IX releases central inhibition on CN VII at the level of the brainstem, resulting in enhanced taste intensity on the anterior tongue. C1 [Doty, Richard L.; Chung, Inna; Pawasarat, Ian; Caulfield, Julie; Leon-Sarmiento, Fidias E.] Hosp Univ Penn, Perelman Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Ctr Smell & Taste, Philadelphia, PA 19104 USA. [Nsoesie, Michael T.] Earlham Coll, Dept Biol, Richmond, IN 47374 USA. [Osman, Allen] Univ Miami, Dept Psychol, Coral Gables, FL 33146 USA. [Hurtig, Howard; Duda, John E.] Univ Penn, Perelman Sch Med, Dept Neurol, Philadelphia, PA 19104 USA. [Silas, Jonathan] Univ Roehampton, Dept Psychol, London SW15 4JD, England. [Dubroff, Jacob] Univ Penn, Perelman Sch Med, Div Nucl Med & Clin Mol Imaging, Dept Radiol, Philadelphia, PA 19104 USA. [Duda, John E.] Philadelphia VA Med Ctr, Parkinsons Dis Res Educ & Clin Ctr, Philadelphia, PA 19104 USA. [Ying, Gui-Shuang] Univ Penn, Dept Ophthalmol, Perelman Sch Med, Philadelphia, PA 19104 USA. [Ying, Gui-Shuang] Univ Penn, Ctr Clin Epidemiol & Biostat, Perelman Sch Med, Philadelphia, PA 19104 USA. [Tekeli, Hakan] Haydarpasa Training Hosp GATA, Dept Neurol, TR-34668 Istanbul, PK, Turkey. RP Doty, RL (reprint author), Hosp Univ Penn, Perelman Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Ctr Smell & Taste, 5 Ravdin Pavil,3400 Spruce St, Philadelphia, PA 19104 USA. EM richard.doty@uphs.upenn.edu FU USAMRAA [W81XWH-09-1-0467] FX This research was supported by USAMRAA W81XWH-09-1-0467. We thank the following persons for their assistance on this project: Jessica Morton, Megan Blair, Emma Harmon, Thelma McCloskey, Ellen Carson, Nancy Wintering, Jonathan Silas, Dandy Zhu, Zackary Salman, and Kelly Cathey. NR 33 TC 5 Z9 5 U1 1 U2 11 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0340-5354 EI 1432-1459 J9 J NEUROL JI J. Neurol. PD MAR PY 2015 VL 262 IS 3 BP 547 EP 557 DI 10.1007/s00415-014-7589-z PG 11 WC Clinical Neurology SC Neurosciences & Neurology GA CE0BX UT WOS:000351469200006 PM 25480568 ER PT J AU Gros, DF Farmer, AS McCabe, RE Antony, MM AF Gros, Daniel F. Farmer, Antonina S. McCabe, Randi E. Antony, Martin M. TI Psychometric Evaluation of the Multidimensional Assessment of Social Anxiety Before and After Cognitive Behavioral Therapy for Social Anxiety Disorder SO JOURNAL OF PSYCHOPATHOLOGY AND BEHAVIORAL ASSESSMENT LA English DT Article DE Multidimensional Assessment of Social Anxiety; MASA; Social anxiety disorder; Social phobia; Transdiagnostic; Hybrid model ID POSTTRAUMATIC-STRESS-DISORDER; RANDOMIZED CONTROLLED-TRIAL; PHOBIA INVENTORY; SYMPTOM OVERLAP; MOOD DISORDERS; DEPRESSION; MODEL; CLASSIFICATION; COMORBIDITY; VERSION AB Due to ongoing criticism of the current diagnostic system, hybrid models of psychopathology, involving the combination of the categorical approach to diagnoses with shared symptom dimensions that are common across various disorders, have received increasing attention in the literature for the depressive and anxiety disorders. One of the few empirically-derived hybrid models was recently developed for social anxiety disorder (SOC) and subsequently led to a self-report measure entitled the Multidimensional Assessment of Social Anxiety (MASA). Although initial support has been provided for the psychometric properties of the MASA, additional research is needed. The present study investigated the internal consistency, convergent and discriminant validity, and sensitivity to detect treatment changes of the MASA scales in 116 participants with SOC that completed the measure at pretreatment and posttreatment during a trial of group cognitive behavioral therapy (CBT) for SOC. The MASA scales demonstrated acceptable sensitivity to detect symptom changes during treatment, convergent validity with related measures of SOC, and internal consistency. In addition, the observed pattern of symptom changes across the MASA scales appeared to be most consistent with the goals/techniques involved in CBT for SOC (e.g., largest improvements in behavioral avoidance; smallest improvements in substance use). Together, these findings provide additional support for psychometric properties of the MASA scales as well as the growing movement towards transdiagnostic assessment and treatment practices. C1 [Gros, Daniel F.; Farmer, Antonina S.] Ralph H Johnson Vet Affairs Med Ctr, Mental Hlth Serv 116, Charleston, SC 29401 USA. [Gros, Daniel F.; Farmer, Antonina S.] Med Univ S Carolina, Dept Psychiat & Behav Sci, Charleston, SC 29425 USA. [McCabe, Randi E.] St Josephs Healthcare, Anxiety Treatment & Res Ctr, Hamilton, ON, Canada. [McCabe, Randi E.] McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON, Canada. [Antony, Martin M.] Ryerson Univ, Dept Psychol, Toronto, ON, Canada. RP Gros, DF (reprint author), Ralph H Johnson Vet Affairs Med Ctr, Mental Hlth Serv 116, 109 Bee St, Charleston, SC 29401 USA. EM grosd@musc.edu FU Department of Veteran Affairs Clinical Sciences Research and Development Career Development Award [CX000845] FX This study is supported by Department of Veteran Affairs Clinical Sciences Research and Development Career Development Award CX000845 (PI: Gros), as well as with resources and the use of facilities at the Ralph H. Johnson VAMC. The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs or the United States government. NR 37 TC 0 Z9 0 U1 4 U2 8 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0882-2689 EI 1573-3505 J9 J PSYCHOPATHOL BEHAV JI J. Psychopathol. Behav. Assess. PD MAR PY 2015 VL 37 IS 1 BP 144 EP 152 DI 10.1007/s10862-014-9443-0 PG 9 WC Psychology, Clinical SC Psychology GA CD7ZZ UT WOS:000351316200014 ER PT J AU Dana, AN Bauman, WA AF Dana, Ali N. Bauman, William A. TI Bacteriology of pressure ulcers in individuals with spinal cord injury: What we know and what we should know SO JOURNAL OF SPINAL CORD MEDICINE LA English DT Review DE Pressure ulcer; Spinal cord injury; Bacteria; Bacteriology; Wound care ID RESISTANT STAPHYLOCOCCUS-AUREUS; HUMAN SKIN MICROBIOTA; CHRONIC WOUNDS; PSEUDOMONAS-AERUGINOSA; KLEBSIELLA-PNEUMONIAE; DECUBITUS ULCERS; NASAL COLONIZATION; MOLECULAR ANALYSIS; MRSA COLONIZATION; INFECTIONS AB Individuals with spinal cord injury (SCI) are at increased risk for the development of pressure ulcers. These chronic wounds are debilitating and contribute to prolonged hospitalization and worse medical outcome. However, the species of bacteria and the role that specific species may play in delaying the healing of chronic pressure ulcers in the SCI population has not been well characterized. This study will review the literature regarding what is known currently about the bacteriology of pressure ulcers in individuals with SCI. An electronic literature search of MEDLINE (1966 to February 2014) was performed. Eleven studies detailing bacterial cultures of pressure ulcers in the SCI population met inclusion criteria and were selected for review. Among these studies, bacterial cultures were often polymicrobial with both aerobic and anaerobic bacteria identified with culture techniques that varied significantly. The most common organisms identified in pressure ulcers were Staphylococcus aureus, Proteus mirabilis, Pseudomonas aeruginosa, and Enterococcus faecalis. In general, wounds were poorly characterized with minimal to no physical description and/or location provided. Our present understanding of factors that may alter the microbiome of pressure ulcers in individuals with SCI is quite rudimentary, at best. Well-designed studies are needed to assess appropriate wound culture technique, the impact of bacterial composition on wound healing, development of infection, and the optimum medical and surgical approaches to wound care. C1 [Dana, Ali N.] James J Peters Vet Affairs Med Ctr, Dermatol Serv, Bronx, NY 10468 USA. [Dana, Ali N.] Columbia Univ, Dept Dermatol, Sch Med, New York, NY 10027 USA. [Bauman, William A.] James J Peters Vet Affairs Med Ctr, Dept Vet Affairs Rehabil Res & Dev Serv, Natl Ctr Excellence Med Consequences Spinal Cord, Bronx, NY 10468 USA. [Bauman, William A.] James J Peters Vet Affairs Med Ctr, Med Serv, Bronx, NY 10468 USA. [Bauman, William A.] Ichan Sch Med Mt Sinai, Dept Med & Rehabil Med, New York, NY USA. RP Dana, AN (reprint author), James J Peters Vet Affairs Med Ctr, Dermatol Serv, Suite 2F,130 West Kingsbridge Rd, Bronx, NY 10468 USA. EM Ali.Dana.@va.gov FU James J. Peters Veterans Affairs Medical Center; Department of Veterans Affairs Rehabilitation Research and Development Service [B2468-C, B4162-C] FX Support for this work was provided by the James J. Peters Veterans Affairs Medical Center and the Department of Veterans Affairs Rehabilitation Research and Development Service (#B2468-C, #B4162-C) and the James J. Peters Veterans Affairs Medical Center. NR 82 TC 4 Z9 4 U1 0 U2 1 PU MANEY PUBLISHING PI LEEDS PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND SN 1079-0268 EI 2045-7723 J9 J SPINAL CORD MED JI J. Spinal Cord. Med. PD MAR PY 2015 VL 38 IS 2 BP 147 EP 160 DI 10.1179/2045772314Y.0000000234 PG 14 WC Clinical Neurology SC Neurosciences & Neurology GA CD4RX UT WOS:000351072300005 PM 25130374 ER PT J AU Wheeler, JB Mukherjee, R Stroud, RE Jones, JA Ikonomidis, JS AF Wheeler, Jason B. Mukherjee, Rupak Stroud, Robert E. Jones, Jeffrey A. Ikonomidis, John S. TI Relation of Murine Thoracic Aortic Structural and Cellular Changes With Aging to Passive and Active Mechanical Properties SO JOURNAL OF THE AMERICAN HEART ASSOCIATION LA English DT Article DE aging; aorta; compliance; contractility ID AGE-RELATED-CHANGES; INTIMA-MEDIA THICKNESS; ARTERIAL STIFFNESS; COMPUTED-TOMOGRAPHY; RAT AORTA; DIAMETER; ANEURYSM; COLLAGEN; GENDER; MATRIX AB Background-Maintenance of the structure and mechanical properties of the thoracic aorta contributes to aortic function and is dependent on the composition of the extracellular matrix and the cellular content within the aortic wall. Age-related alterations in the aorta include changes in cellular content and composition of the extracellular matrix; however, the precise roles of these agerelated changes in altering aortic mechanical function are not well understood. Methods and Results-Thoracic aortic rings from the descending segment were harvested from C57BL/6 mice aged 6 and 21 months. Thoracic aortic diameter and wall thickness were higher in the old mice. Cellular density was reduced in the medial layer of aortas from the old mice; concomitantly, collagen content was higher in old mice, but elastin content was similar between young and old mice. Stress relaxation, an index of compliance, was reduced in aortas from old mice and correlated with collagen fraction. Contractility of the aortic rings following potassium stimulation was reduced in old versus young mice. Furthermore, collagen gel contraction by aortic smooth muscle cells was reduced with age. Conclusions-These results demonstrate that numerous age-related structural changes occurred in the thoracic aorta and were related to alterations in mechanical properties. Aortic contractility decreased with age, likely because of a reduction in medial cell number in addition to a smooth muscle contractile deficit. Together, these unique findings provide evidence that the age-related changes in structure and mechanical function coalesce to provide an aortic substrate that may be predisposed to aortopathies. C1 [Wheeler, Jason B.; Mukherjee, Rupak; Stroud, Robert E.; Jones, Jeffrey A.; Ikonomidis, John S.] Med Univ S Carolina, Div Cardiothorac Surg, Charleston, SC 29425 USA. [Jones, Jeffrey A.] Ralph H Johnson Vet Affairs Med Ctr, Charleston, SC USA. RP Jones, JA (reprint author), Med Univ S Carolina, Cardiothorac Surg Res, Strom Thurmond Res Bldg,114 Doughty St,Suite 338, Charleston, SC 29425 USA. EM jonesja@musc.edu FU NIH National Institute on Aging [R01 AG036854]; VA BLRD Merit Award [2I01 BX000904-04]; [T32 HL007260-37] FX This study was supported by NIH National Institute on Aging Grant R01 AG036854 (J.S.I.), VA BLR&D Merit Award 2I01 BX000904-04 (J.A.J.), and by T32 HL007260-37 (J.B.W.). NR 49 TC 3 Z9 3 U1 0 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2047-9980 J9 J AM HEART ASSOC JI J. Am. Heart Assoc. PD MAR PY 2015 VL 4 IS 3 AR e001744 DI 10.1161/JAHA.114.001744 PG 9 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA CE0TV UT WOS:000351520300028 PM 25716945 ER PT J AU Bishnoi, RJ Baig, MR Brown, FW AF Bishnoi, Ram Jeevan Baig, Muhammad Rais Brown, Frederick William TI A case of nicotine withdrawal delirium SO JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION LA English DT Editorial Material DE Delirium; Nicotine; Withdrawals AB Nicotine withdrawal is not a well recognized cause of delirium. A few published cases are on post-operative, terminally ill cancer or neuro-intensive care unit patients. Because of the high incidence of morbidity and mortality of delirium it is important to identify and treat delirium promptly and effectively. We report a case of delirium after sudden cessation of smoking in a heavy smoker, with schizophrenia, hospitalized for stabilization of psychiatric illness. C1 [Bishnoi, Ram Jeevan] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Baig, Muhammad Rais; Brown, Frederick William] Audie L Murphy VA Hosp, South Texas Vet Hlth Care Syst, San Antonio, TX 78229 USA. RP Baig, MR (reprint author), Audie L Murphy VA Hosp, South Texas Vet Hlth Care Syst, San Antonio, TX 78229 USA. EM muhammad.baig@va.gov NR 5 TC 1 Z9 1 U1 0 U2 0 PU PAKISTAN MEDICAL ASSOC PI KARACHI PA PMA HOUSE, AGA KHAN III RD, KARACHI, 00000, PAKISTAN SN 0030-9982 J9 J PAK MED ASSOC JI J. Pak. Med. Assoc. PD MAR PY 2015 VL 65 IS 3 BP 320 EP 321 PG 2 WC Medicine, General & Internal; Medicine, Research & Experimental SC General & Internal Medicine; Research & Experimental Medicine GA CD9NI UT WOS:000351424600022 PM 25933572 ER PT J AU Graham, DY AF Graham, David Y. TI Roadmap for elimination of gastric cancer in Korea SO KOREAN JOURNAL OF INTERNAL MEDICINE LA English DT Review ID HELICOBACTER-PYLORI-INFECTION; ERADICATION THERAPY; TRIPLE THERAPY; 1ST-LINE; JAPAN; SURVEILLANCE; TRENDS; TIME; RISK AB Most gastric cancers are caused by infection with the common human bacterial pathogen, Helicobacter pylori. It is now accepted that gastric cancer can be prevented and virtually eliminated by H. pylori eradication and this knowledge was responsible for country-wide H. pylori eradication combined with secondary cancer prevention for those with residual risk that was introduced in Japan in 2013. Korea is a high H. pylori prevalence and high gastric cancer incidence country and a good candidate for a gastric cancer elimination program. The presence of an H. pylori infection is now considered as an indication for treatment of the infection. However, antimicrobial drug resistance is common among H. pylori in Korea making effective therapy problematic. Country-wide studies of the local and regional antimicrobial resistance patterns are needed to choose the most appropriate therapies. H. pylori and gastric cancer eradication can be both efficient and cost effective making it possible and practical to make Korea H. pylori and gastric cancer free. There is no reason to delay. C1 Baylor Coll Med, Dept Med, Michael E DeBakey Vet Affairs Med Ctr, Houston, TX 77030 USA. RP Graham, DY (reprint author), Baylor Coll Med, Dept Med, Michael E DeBakey Vet Affairs Med Ctr, 2002 Holcombe Blvd, Houston, TX 77030 USA. EM dgraham@bcm.edu FU Office of Research and Development Medical Research Service Department of Veterans Affairs, Public Health Service [DK067366, DK56338] FX The author thanks Dr. Sun-Young Lee for reading the draft manuscript and making important suggestions. Dr. Graham is supported in part by the Office of Research and Development Medical Research Service Department of Veterans Affairs, Public Health Service grants DK067366 and DK56338 which funds the Texas Medical Center Digestive Diseases Center. The contents are solely the responsibility of the authors and do not necessarily represent the official views of the VA or NIH. NR 32 TC 3 Z9 3 U1 0 U2 3 PU KOREAN ASSOC INTERNAL MEDICINE PI SEOUL PA 101-2501 LOTTE CASTLE PRESIDENT, 109 MAPO-DAERO, MAPO-GU, SEOUL, 121-916, SOUTH KOREA SN 1226-3303 J9 KOREAN J INTERN MED JI Korean J. Intern. Med. PD MAR PY 2015 VL 30 IS 2 BP 133 EP 139 DI 10.3904/kjim.2015.30.2.133 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA CD9LL UT WOS:000351419700001 PM 25750552 ER EF