 ELS FOCE/general Laplace engine log file 

 MAX major iterations =         100
 MAX Niter (line searches per major iteration) =        1000


 Model evaluation ODE level used:
  6=matrix exponent

 Other flags and run conditions/tolerances:

       100  NSUB
        13  NUMFREEPARAM
         6  NUMFREEFIXEF
         1  NUMFREEEPS  
         6  NUMFREEOMEGAPARAM
         6  NUMRANEF
         1  Allow Gaussian Fit
         5  IDENGINE
         0  IFLAGRESTART
         1  IFLAGSTDERR 
         0  IFLAGNP     
         1  IFLAGFOCEHESS
         1  NORDERAGQ
         4  NUMPROCS 
        13  NDIGITblup 
         7  NDIGITlagl 
 0.200E-02  tolmodlinz 
 0.100E-01  tolstderr  
         0  NREP_PCWRES
         1  NPRESAMPLE 
         0  NGETMAPNP  
           0  iflaganagrad
           6  iodelevelused
           1  iflagstderr 
           1  iflagwhichstderr


 Initial parameter values:

  0.20000000E+01        1   1 THETA
  0.50000000E+01        2   1 THETA
  0.20000000E+01        3   1 THETA
  0.10000000E+01        4   1 THETA
  0.20000000E+01        5   1 THETA
  0.10000000E+01        6   1 THETA
  0.50000000E+00        1   1 EPS_STD_DEV
  0.25000000E+00        1   1 EPS_VARIANCE
  0.10000000E+00        1   1 OMEGA
  0.00000000E+00        2   1 OMEGA
  0.10000000E+00        2   2 OMEGA
  0.00000000E+00        3   1 OMEGA
  0.00000000E+00        3   2 OMEGA
  0.10000000E+00        3   3 OMEGA
  0.00000000E+00        4   1 OMEGA
  0.00000000E+00        4   2 OMEGA
  0.00000000E+00        4   3 OMEGA
  0.10000000E+00        4   4 OMEGA
  0.00000000E+00        5   1 OMEGA
  0.00000000E+00        5   2 OMEGA
  0.00000000E+00        5   3 OMEGA
  0.00000000E+00        5   4 OMEGA
  0.10000000E+00        5   5 OMEGA
  0.00000000E+00        6   1 OMEGA
  0.00000000E+00        6   2 OMEGA
  0.00000000E+00        6   3 OMEGA
  0.00000000E+00        6   4 OMEGA
  0.00000000E+00        6   5 OMEGA
  0.10000000E+00        6   6 OMEGA
 -0.52389994E+03        1   1 -LOGLIKE
 -0.43559786E+04        1   1 ELSOBJ  

 Total # Subjects     =         100
 Total # Observations =        1800


 FOCE Hessian approximation used
iteration =     1    LL value =   -953.14115    
iteration =     2    LL value =   -1263.1356    
iteration =     3    LL value =   -1526.5694    
iteration =     4    LL value =   -2088.4963    
iteration =     5    LL value =   -2182.7571    
iteration =     6    LL value =   -2236.1511    
iteration =     7    LL value =   -2548.2247    
iteration =     8    LL value =   -2552.4678    
iteration =     9    LL value =   -2613.7391    
iteration =    10    LL value =   -2921.7682    
iteration =    11    LL value =   -3629.1307    
iteration =    12    LL value =   -3743.7102    
iteration =    13    LL value =   -4277.5008    
iteration =    14    LL value =   -4506.4821    
iteration =    15    LL value =   -4567.9147    
iteration =    16    LL value =   -4649.1719    
iteration =    17    LL value =   -4858.9654    
iteration =    18    LL value =   -4870.3008    
iteration =    19    LL value =   -4886.0732    
iteration =    20    LL value =   -4947.3448    
iteration =    21    LL value =   -4977.8615    
iteration =    22    LL value =   -5007.6374    
iteration =    23    LL value =   -5008.1434    
iteration =    24    LL value =   -5069.8052    
iteration =    25    LL value =   -5124.1940    
iteration =    26    LL value =   -5126.7897    
iteration =    27    LL value =   -5132.6772    
iteration =    28    LL value =   -5145.2402    
iteration =    29    LL value =   -5148.8892    
iteration =    30    LL value =   -5161.2028    
iteration =    31    LL value =   -5164.2473    
iteration =    32    LL value =   -5182.6069    
iteration =    33    LL value =   -5217.9075    
iteration =    34    LL value =   -5231.7280    
iteration =    35    LL value =   -5235.3112    
iteration =    36    LL value =   -5245.9554    
iteration =    37    LL value =   -5248.2366    
iteration =    38    LL value =   -5248.4181    
iteration =    39    LL value =   -5352.8043    
iteration =    40    LL value =   -5353.4926    
iteration =    41    LL value =   -5356.7064    
iteration =    42    LL value =   -5357.6412    
iteration =    43    LL value =   -5357.7097    
iteration =    44    LL value =   -5358.6982    
iteration =    45    LL value =   -5359.3477    
iteration =    46    LL value =   -5363.2166    
iteration =    47    LL value =   -5367.3401    
iteration =    48    LL value =   -5371.7662    
iteration =    49    LL value =   -5372.7304    
iteration =    50    LL value =   -5376.1980    
iteration =    51    LL value =   -5377.4797    
iteration =    52    LL value =   -5379.5070    
iteration =    53    LL value =   -5379.5552    
iteration =    54    LL value =   -5379.9932    
iteration =    55    LL value =   -5381.0117    
iteration =    56    LL value =   -5383.3630    
iteration =    57    LL value =   -5384.0867    
iteration =    58    LL value =   -5384.3600    
iteration =    59    LL value =   -5384.5783    
iteration =    60    LL value =   -5384.8567    
iteration =    61    LL value =   -5384.9424    
iteration =    62    LL value =   -5385.0131    
iteration =    63    LL value =   -5385.1531    
iteration =    64    LL value =   -5386.1106    
iteration =    65    LL value =   -5386.7752    
iteration =    66    LL value =   -5388.4623    
iteration =    67    LL value =   -5393.5507    
iteration =    68    LL value =   -5398.5358    
iteration =    69    LL value =   -5406.6805    
iteration =    70    LL value =   -5407.4380    
iteration =    71    LL value =   -5407.9037    
iteration =    72    LL value =   -5408.1745    
iteration =    73    LL value =   -5408.5194    
iteration =    74    LL value =   -5409.3865    
iteration =    75    LL value =   -5410.1508    
iteration =    76    LL value =   -5410.6353    
iteration =    77    LL value =   -5410.7783    
iteration =    78    LL value =   -5410.7788    
iteration =    79    LL value =   -5410.9157    
iteration =    80    LL value =   -5410.9157    
iteration =    81    LL value =   -5411.4863    
iteration =    82    LL value =   -5411.6221    
iteration =    83    LL value =   -5411.7514    
iteration =    84    LL value =   -5411.7827    
iteration =    85    LL value =   -5411.8122    
iteration =    86    LL value =   -5411.8123    
iteration =    87    LL value =   -5411.8167    
iteration =    88    LL value =   -5411.8216    
iteration =    89    LL value =   -5411.8260    
iteration =    90    LL value =   -5411.8277    
iteration =    91    LL value =   -5411.8277    
iteration =    92    LL value =   -6064.8615    
iteration =    93    LL value =   -6093.8285    
iteration =    94    LL value =   -6470.8940    
iteration =    95    LL value =   -6555.1347    
iteration =    96    LL value =   -6588.5632    
iteration =    97    LL value =   -6737.2547    
iteration =    98    LL value =   -6743.9725    
iteration =    99    LL value =   -6744.0375    
iteration =   100    LL value =   -6791.8924    
iteration =   101    LL value =   -6815.6452    
iteration =   102    LL value =   -6829.1692    
iteration =   103    LL value =   -6834.8786    
iteration =   104    LL value =   -6844.5406    
iteration =   105    LL value =   -6844.5417    
iteration =   106    LL value =   -6849.3927    
iteration =   107    LL value =   -6864.9700    
iteration =   108    LL value =   -6867.4459    
iteration =   109    LL value =   -6870.6718    
iteration =   110    LL value =   -6870.6724    
iteration =   111    LL value =   -6870.6745    
iteration =   112    LL value =   -6870.6745    
 Main umdriver optimization for engine 5 terminated
 ITRMCD exit code from umdriver =            3
 1,2,3 = probable success, 4 = maxiterations reached
 7 = Linesearch failed to find any good gradient to move

 Starting std error computation

 Score based  std error successful
 Standard errors of estimated parameters

internal_coords       Param       Param_val         Std_err     rel_std_err

       1            tvlogCl    0.156722E+01    0.207304E-01    0.132274E-01
       2             tvlogV    0.293999E+01    0.199853E-01    0.679774E-02
       3           tvlogKa1    0.119960E+01    0.656250E-01    0.547057E-01
       4           tvlogKa2    0.635891E+00    0.347596E-01    0.546629E-01
       5          tvlogTlag    0.199145E+01    0.245374E-01    0.123214E-01
       6       tvlogitFrac1    0.377972E+00    0.140673E+00    0.372178E+00
       7               CEps    0.995436E-02    0.214324E-03    0.215307E-01
       8             nlogCl    0.200185E+00    0.162446E-01    0.811479E-01
       9              nlogV    0.340184E+00    0.628899E-01    0.184870E+00
      10            nlogKa1    0.425313E+00    0.600743E-01    0.141247E+00
      11            nlogKa2    0.303295E+00    0.277157E-01    0.913820E-01
      12           nlogTlag    0.925577E+00    0.201515E+00    0.217719E+00
      13        nlogitFrac1    0.605949E+00    0.110539E+00    0.182423E+00


external_coords       Param       Param_val         Std_err     rel_std_err

       1            tvlogCl    0.156722E+01    0.207304E-01    0.132274E-01
       2             tvlogV    0.293999E+01    0.199853E-01    0.679774E-02
       3           tvlogKa1    0.119960E+01    0.656250E-01    0.547057E-01
       4           tvlogKa2    0.635891E+00    0.347596E-01    0.546629E-01
       5          tvlogTlag    0.199145E+01    0.245374E-01    0.123214E-01
       6       tvlogitFrac1    0.377972E+00    0.140673E+00    0.372178E+00
       7               CEps    0.995436E-02    0.214324E-03    0.215307E-01
       8             nlogCl    0.400739E-01    0.650382E-02    0.162296E+00
       9              nlogV    0.115725E+00    0.427883E-01    0.369740E+00
      10            nlogKa1    0.180891E+00    0.511007E-01    0.282494E+00
      11            nlogKa2    0.919880E-01    0.168121E-01    0.182764E+00
      12           nlogTlag    0.856692E+00    0.373035E+00    0.435437E+00
      13        nlogitFrac1    0.367174E+00    0.133962E+00    0.364846E+00


 Warning: Hessian based standard error
 computation failed in Cholesky factorization step
 of numerical Hessian of -2LL function
 infohess from dpotrf =           4
 Sandwich std error computation thus also fails

 Engine Convergence Summary:
 Convergence achieved

 ITRMCD value on last iteration =           3
 NLME7 return code=           3

 Optimal parameters:

  0.15672238E+01        1   1 THETA        BOUNDS:  -0.100+101  0.100+101
  0.29399890E+01        2   1 THETA        BOUNDS:  -0.100+101  0.100+101
  0.11996016E+01        3   1 THETA        BOUNDS:  -0.100+101  0.100+101
  0.63589053E+00        4   1 THETA        BOUNDS:  -0.100+101  0.100+101
  0.19914500E+01        5   1 THETA        BOUNDS:  -0.100+101  0.100+101
  0.37797250E+00        6   1 THETA        BOUNDS:  -0.100+101  0.100+101
  0.99543607E-02        1   1 EPS_STD_DEV  BOUNDS:   0.100E-02  0.100+101
  0.99089298E-04        1   1 EPS_VARIANCE
  0.40073896E-01        1   1 OMEGA
  0.00000000E+00        2   1 OMEGA
  0.11572525E+00        2   2 OMEGA
  0.00000000E+00        3   1 OMEGA
  0.00000000E+00        3   2 OMEGA
  0.18089109E+00        3   3 OMEGA
  0.00000000E+00        4   1 OMEGA
  0.00000000E+00        4   2 OMEGA
  0.00000000E+00        4   3 OMEGA
  0.91988014E-01        4   4 OMEGA
  0.00000000E+00        5   1 OMEGA
  0.00000000E+00        5   2 OMEGA
  0.00000000E+00        5   3 OMEGA
  0.00000000E+00        5   4 OMEGA
  0.85669189E+00        5   5 OMEGA
  0.00000000E+00        6   1 OMEGA
  0.00000000E+00        6   2 OMEGA
  0.00000000E+00        6   3 OMEGA
  0.00000000E+00        6   4 OMEGA
  0.00000000E+00        6   5 OMEGA
  0.36717398E+00        6   6 OMEGA
 -0.68706745E+04        1   1 -LOGLIKE
 -0.17049528E+05        1   1 ELSOBJ  

  EPSILON SHRINKAGES
  Epsilon shrinkage for CEps =     0.183014

 ETA SHRINKAGES
   eta-shrinkage( 1) =          0.03217
   eta-shrinkage( 2) =          0.35058
   eta-shrinkage( 3) =          0.24115
   eta-shrinkage( 4) =          0.08942
   eta-shrinkage( 5) =          0.78611
   eta-shrinkage( 6) =          0.70064

 RUNTIMES

   engine runtime (secs) =    184.141
   stderr runtime (secs) =     39.844

 EXITCODE            3
