 ELS FOCE/general Laplace engine log file 

 MAX major iterations =         100
 MAX Niter (line searches per major iteration) =        1000


 Model evaluation ODE level used:
  0=none

 Other flags and run conditions/tolerances:

       200  NSUB
         5  NUMFREEPARAM
         3  NUMFREEFIXEF
         1  NUMFREEEPS  
         1  NUMFREEOMEGAPARAM
         1  NUMRANEF
         1  Allow Gaussian Fit
         5  IDENGINE
         0  IFLAGRESTART
         1  IFLAGSTDERR 
         0  IFLAGNP     
         0  IFLAGFOCEHESS
         1  NORDERAGQ
         4  NUMPROCS 
        13  NDIGITblup 
         7  NDIGITlagl 
 0.200E-02  tolmodlinz 
 0.100E-01  tolstderr  
         0  NREP_PCWRES
         1  NPRESAMPLE 
         0  NGETMAPNP  
           0  iflaganagrad
           0  iodelevelused
           1  iflagstderr 
           1  iflagwhichstderr


 Initial parameter values:

  0.50000000E+01        1   1 THETA
  0.10000000E+01        2   1 THETA
  0.10000000E+02        3   1 THETA
  0.10000000E+01        1   1 EPS_STD_DEV
  0.10000000E+01        1   1 EPS_VARIANCE
  0.10000000E+01        1   1 OMEGA
  0.10850203E+05        1   1 -LOGLIKE
  0.15819199E+05        1   1 ELSOBJ  

 Total # Subjects     =         200
 Total # Observations =        3200


 LAPLACE Hessian approximation used
iteration =     1    LL value =    10249.796    
iteration =     2    LL value =    10006.569    
iteration =     3    LL value =    9739.8198    
iteration =     4    LL value =    9438.7204    
iteration =     5    LL value =    9093.3814    
iteration =     6    LL value =    8702.7848    
iteration =     7    LL value =    8262.3264    
iteration =     8    LL value =    7778.0586    
iteration =     9    LL value =    7260.8038    
iteration =    10    LL value =    6735.3166    
iteration =    11    LL value =    5574.8855    
iteration =    12    LL value =    5425.2883    
iteration =    13    LL value =    5359.8639    
iteration =    14    LL value =    5343.6066    
iteration =    15    LL value =    5326.0245    
iteration =    16    LL value =    5248.5172    
iteration =    17    LL value =    5237.0989    
iteration =    18    LL value =    5151.8826    
iteration =    19    LL value =    5085.3804    
iteration =    20    LL value =    5068.1772    
iteration =    21    LL value =    5048.9590    
iteration =    22    LL value =    5041.4567    
iteration =    23    LL value =    5040.9953    
iteration =    24    LL value =    5040.9849    
iteration =    25    LL value =    5040.9813    
iteration =    26    LL value =    5040.9810    
iteration =    27    LL value =    5040.9805    
iteration =    28    LL value =    5040.9794    
iteration =    29    LL value =    5040.9793    
iteration =    30    LL value =    5040.9788    
iteration =    31    LL value =    5040.9778    
iteration =    32    LL value =    5040.9774    
iteration =    33    LL value =    5040.9772    
 Main umdriver optimization for engine 5 terminated
 ITRMCD exit code from umdriver =            1
 1,2,3 = probable success, 4 = maxiterations reached
 7 = Linesearch failed to find any good gradient to move

 Starting std error computation

 Hessian based std error successful
 Standard errors of estimated parameters

internal_coords  Param       Param_val         Std_err     rel_std_err

       1       tvEC50    0.699082E+01    0.114811E+00    0.164231E-01
       2         tvE0    0.298886E+01    0.122286E-01    0.409139E-02
       3       tvEmax    0.250674E+02    0.155074E+00    0.618626E-02
       4         EEps    0.104858E+00    0.136653E-02    0.130322E-01
       5        nEC50    0.722120E-01    0.928296E-02    0.128551E+00


external_coords  Param       Param_val         Std_err     rel_std_err

       1       tvEC50    0.699082E+01    0.114811E+00    0.164231E-01
       2         tvE0    0.298886E+01    0.122286E-01    0.409139E-02
       3       tvEmax    0.250674E+02    0.155074E+00    0.618626E-02
       4         EEps    0.104858E+00    0.136653E-02    0.130322E-01
       5        nEC50    0.521458E-02    0.134068E-02    0.257103E+00


 Score based  std error successful
 Standard errors of estimated parameters

internal_coords  Param       Param_val         Std_err     rel_std_err

       1       tvEC50    0.699082E+01    0.112204E+00    0.160502E-01
       2         tvE0    0.298886E+01    0.127588E-01    0.426880E-02
       3       tvEmax    0.250674E+02    0.156164E+00    0.622976E-02
       4         EEps    0.104858E+00    0.136654E-02    0.130323E-01
       5        nEC50    0.722120E-01    0.846851E-02    0.117273E+00


external_coords  Param       Param_val         Std_err     rel_std_err

       1       tvEC50    0.699082E+01    0.112204E+00    0.160502E-01
       2         tvE0    0.298886E+01    0.127588E-01    0.426880E-02
       3       tvEmax    0.250674E+02    0.156164E+00    0.622976E-02
       4         EEps    0.104858E+00    0.136654E-02    0.130323E-01
       5        nEC50    0.521458E-02    0.122306E-02    0.234546E+00


 Sandwich based std error successful
 Standard errors of estimated parameters

internal_coords  Param       Param_val         Std_err     rel_std_err

       1       tvEC50    0.699082E+01    0.118343E+00    0.169283E-01
       2         tvE0    0.298886E+01    0.118465E-01    0.396356E-02
       3       tvEmax    0.250674E+02    0.154842E+00    0.617701E-02
       4         EEps    0.104858E+00    0.138695E-02    0.132270E-01
       5        nEC50    0.722120E-01    0.103043E-01    0.142695E+00


external_coords  Param       Param_val         Std_err     rel_std_err

       1       tvEC50    0.699082E+01    0.118343E+00    0.169283E-01
       2         tvE0    0.298886E+01    0.118465E-01    0.396356E-02
       3       tvEmax    0.250674E+02    0.154842E+00    0.617701E-02
       4         EEps    0.104858E+00    0.138695E-02    0.132270E-01
       5        nEC50    0.521458E-02    0.148819E-02    0.285390E+00


 Engine Convergence Summary:
 Convergence achieved

 ITRMCD value on last iteration =           1
 NLME7 return code=           1

 Optimal parameters:

  0.69908155E+01        1   1 THETA        BOUNDS:  -0.100+101  0.100+101
  0.29888616E+01        2   1 THETA        BOUNDS:  -0.100+101  0.100+101
  0.25067428E+02        3   1 THETA        BOUNDS:  -0.100+101  0.100+101
  0.10485752E+00        1   1 EPS_STD_DEV  BOUNDS:   0.100E-02  0.100+101
  0.10995100E-01        1   1 EPS_VARIANCE
  0.52145754E-02        1   1 OMEGA
  0.50409772E+04        1   1 -LOGLIKE
  0.42007477E+04        1   1 ELSOBJ  
 
 EPSILON SHRINKAGES
  Epsilon shrinkage for EEps =     0.012237

 ETA SHRINKAGES
   eta-shrinkage( 1) =          0.37041

 RUNTIMES

   engine runtime (secs) =      0.906
   stderr runtime (secs) =      0.156

 EXITCODE            1
