Package: POINT
Type: Package
Title: Protein Structure Guided Local Test
Version: 1.4
Date: 2025-05-03
Author: Rachel Marceau West [aut],
  Shannon T. Holloway [aut, cre]
Maintainer: Shannon T. Holloway <shannon.t.holloway@gmail.com>
Authors@R: c(person(given = c("Rachel", "Marceau"),
                        family = "West",
                        role = "aut"),
                 person(given = c("Shannon", "T."),
                        family = "Holloway",
                        role = c("aut", "cre"),
                        email = "shannon.t.holloway@gmail.com"))
Description: Provides an implementation of a rare variant association test that utilizes protein tertiary structure to increase signal and to identify likely causal variants. Performs structure-guided collapsing, which leads to local tests that borrow information from neighboring variants on a protein and that provide association information on a variant-specific level. For details of the implemented method see West, R. M.,  Lu, W., Rotroff, D. M., Kuenemann, M., Chang, S-M., Wagner M. J., Buse, J. B., Motsinger-Reif, A., Fourches, D., and Tzeng, J-Y. (2019) <doi:10.1371/journal.pcbi.1006722>.
License: GPL-2
Depends: methods, stats, rARPACK, Matrix, CompQuadForm
NeedsCompilation: no
Encoding: UTF-8
RoxygenNote: 7.2.1
Collate: 'A_Kernel.R' 'A_BurdenKernel.R' 'A_LinearKernel.R'
        'A_PolyKernel.R' 'B_PvMethod.R' 'B_PvMethod_Davies.R'
        'B_PvMethod_Liu.R' 'C_BinomialTrait.R' 'C_GaussianTrait.R'
        'D_NullResult.R' 'calcLocalKernel.R' 'distanceMatrix.R'
        'mainCode.R' 'point.R' 'pvResamp.R'
Packaged: 2025-05-04 13:24:27 UTC; 19194
Repository: CRAN
Date/Publication: 2025-05-04 13:40:02 UTC
Built: R 4.6.0; ; 2026-04-25 15:37:43 UTC; unix
