R: Two-Stage Adaptive Dose-Finding Clinical Trial Design

# Two-Stage Adaptive Dose-Finding Clinical Trial Design

## Documentation for package ‘iAdapt’ version 2.0.1

- DESCRIPTION file
- User guides, package vignettes and other documentation
- Package README

## Help Pages

dlt.prob | Calculate DLT probability corresponding to average nTTP for each dose
eff.stg1 | Generates efficacy outcomes for stage 1 when using binary toxicity
eff.stg1.nTTP | Generates efficacy outcomes for stage 1 when using nTTP to measure toxicity
get.thresh | Obtain average nTTP at each dose level
LRtox | Calculates likelihood of safety for single dose
LRtox.nTTP | Calculates likelihood of safety for single dose, using nTTP
nTTP.indiv.sim | Simulate full trial (both stages) x times when using nTTP to measure toxicity
rand.prob | Calculates randomization probabilities and dose allocation for next patient
rand.stg2 | Stage 2 Adaptive Randomization
rand.stg2.nTTP | Stage 2 Adaptive Randomization with nTTP to monitor toxicity
safe.dose | Identify safe/acceptable doses from stage 1 based on observed binary toxicity
safe.dose.nTTP | Identify safe/acceptable doses from stage 1 based on nTTP scores.
sim.plot | Generate plots for estimated percent allocation and response per dose.
sim.summary | Visualize simulation results (Stages 1&2)
sim.trials | Simulate full trial (both stages) x times
sim.trials.nTTP | Simulate full trial (both stages) x times when using nTTP to measure toxicity
TOX | Sample array of toxicity probabilities for 6 doses. Taken from Du et al.
tox.profile | Generates DLTs and calculates the likelihood-ratio (LR) for each dose
tox.profile.nTTP | Generate nTTPs toxicity scores and the likelihhood-ratio (LR) per dose