Author: Bill Denney

# Methods Used for Dose-Aware Concentration Interpolation/Extrapolation

#### Bill Denney

# Introduction

Interpolation and extrapolation with awareness of doses occurring before, at the same time of, or after the requested interpolation time point must account for many interactions. To ensure clarity in the interpolation/extrapolation methods and the decisions made by the algorithm, each potential choice is listed below with its accompanying calculation method. The code used to generate the table is the same as the code within the function.

# Methods

The method list below is described and sorted in order of how many scenarios the method is applied to in the list.

For each of the summary tables below, the column headers are as follows:

- Event Before: The type of event before the time of the requested output may be one of the following
- Event At: The equivalent to “Event Before” but for the event occurring at the requested output time.
- Event After: The equivalent to “Event Before” but for the next event occurring after the requested output time.

## Observed concentration

Copy the input concentration at the given time to the output.

Event Before | Event At | Event After
--- | --- | ---
conc | conc | conc
conc | conc | conc_dose
conc | conc | conc_dose_iv_bolus_after
conc | conc | dose
conc | conc | dose_iv_bolus_after
conc | conc | none
conc | conc_dose | conc
conc | conc_dose | conc_dose
conc | conc_dose | conc_dose_iv_bolus_after
conc | conc_dose | dose
conc | conc_dose | dose_iv_bolus_after
conc | conc_dose | none
conc | conc_dose_iv_bolus_after | conc
conc | conc_dose_iv_bolus_after | conc_dose
conc | conc_dose_iv_bolus_after | dose
conc | conc_dose_iv_bolus_after | none
conc_dose | conc | conc
conc_dose | conc | conc_dose
conc_dose | conc | conc_dose_iv_bolus_after
conc_dose | conc | dose
conc_dose | conc | dose_iv_bolus_after
conc_dose | conc | none
conc_dose | conc_dose | conc
conc_dose | conc_dose | conc_dose
conc_dose | conc_dose | conc_dose_iv_bolus_after
conc_dose | conc_dose | dose
conc_dose | conc_dose | dose_iv_bolus_after
conc_dose | conc_dose | none
conc_dose | conc_dose_iv_bolus_after | conc
conc_dose | conc_dose_iv_bolus_after | conc_dose
conc_dose | conc_dose_iv_bolus_after | dose
conc_dose | conc_dose_iv_bolus_after | none
conc_dose_iv_bolus_after | conc | conc
conc_dose_iv_bolus_after | conc | conc_dose
conc_dose_iv_bolus_after | conc | conc_dose_iv_bolus_after
conc_dose_iv_bolus_after | conc | dose
conc_dose_iv_bolus_after | conc | dose_iv_bolus_after
conc_dose_iv_bolus_after | conc | none
conc_dose_iv_bolus_after | conc_dose | conc
conc_dose_iv_bolus_after | conc_dose | conc_dose
conc_dose_iv_bolus_after | conc_dose | conc_dose_iv_bolus_after
conc_dose_iv_bolus_after | conc_dose | dose
conc_dose_iv_bolus_after | conc_dose | dose_iv_bolus_after
conc_dose_iv_bolus_after | conc_dose | none
dose | conc | conc
dose | conc | conc_dose
dose | conc | conc_dose_iv_bolus_after
dose | conc | dose
dose | conc | dose_iv_bolus_after
dose | conc | none
dose | conc_dose | conc
dose | conc_dose | conc_dose
dose | conc_dose | conc_dose_iv_bolus_after
dose | conc_dose | dose
dose | conc_dose | dose_iv_bolus_after
dose | conc_dose | none
dose | conc_dose_iv_bolus_after | conc
dose | conc_dose_iv_bolus_after | conc_dose
dose | conc_dose_iv_bolus_after | dose
dose | conc_dose_iv_bolus_after | none
dose_iv_bolus_after | conc | conc
dose_iv_bolus_after | conc | conc_dose
dose_iv_bolus_after | conc | conc_dose_iv_bolus_after
dose_iv_bolus_after | conc | dose
dose_iv_bolus_after | conc | dose_iv_bolus_after
dose_iv_bolus_after | conc | none
dose_iv_bolus_after | conc_dose | conc
dose_iv_bolus_after | conc_dose | conc_dose
dose_iv_bolus_after | conc_dose | conc_dose_iv_bolus_after
dose_iv_bolus_after | conc_dose | dose
dose_iv_bolus_after | conc_dose | dose_iv_bolus_after
dose_iv_bolus_after | conc_dose | none
none | conc | conc
none | conc | conc_dose
none | conc | conc_dose_iv_bolus_after
none | conc | dose
none | conc | dose_iv_bolus_after
none | conc | none
none | conc_dose | conc
none | conc_dose | conc_dose
none | conc_dose | conc_dose_iv_bolus_after
none | conc_dose | dose
none | conc_dose | dose_iv_bolus_after
none | conc_dose | none
none | conc_dose_iv_bolus_after | conc
none | conc_dose_iv_bolus_after | conc_dose
none | conc_dose_iv_bolus_after | dose
none | conc_dose_iv_bolus_after | none

## Impossible combinations

The event combination cannot exist.

Event Before | Event At | Event After
--- | --- | ---
conc | conc_dose_iv_bolus_after | conc_dose_iv_bolus_after
conc | conc_dose_iv_bolus_after | dose_iv_bolus_after
conc | dose_iv_bolus_after | conc_dose_iv_bolus_after
conc | dose_iv_bolus_after | dose_iv_bolus_after
conc | output_only | conc_dose_iv_bolus_after
conc | output_only | dose_iv_bolus_after
conc_dose | conc_dose_iv_bolus_after | conc_dose_iv_bolus_after
conc_dose | conc_dose_iv_bolus_after | dose_iv_bolus_after
conc_dose | dose_iv_bolus_after | conc_dose_iv_bolus_after
conc_dose | dose_iv_bolus_after | dose_iv_bolus_after
conc_dose | output_only | conc_dose_iv_bolus_after
conc_dose | output_only | dose_iv_bolus_after
conc_dose_iv_bolus_after | conc_dose_iv_bolus_after | conc
conc_dose_iv_bolus_after | conc_dose_iv_bolus_after | conc_dose
conc_dose_iv_bolus_after | conc_dose_iv_bolus_after | conc_dose_iv_bolus_after
conc_dose_iv_bolus_after | conc_dose_iv_bolus_after | dose
conc_dose_iv_bolus_after | conc_dose_iv_bolus_after | dose_iv_bolus_after
conc_dose_iv_bolus_after | conc_dose_iv_bolus_after | none
conc_dose_iv_bolus_after | dose_iv_bolus_after | conc
conc_dose_iv_bolus_after | dose_iv_bolus_after | conc_dose
conc_dose_iv_bolus_after | dose_iv_bolus_after | conc_dose_iv_bolus_after
conc_dose_iv_bolus_after | dose_iv_bolus_after | dose
conc_dose_iv_bolus_after | dose_iv_bolus_after | dose_iv_bolus_after
conc_dose_iv_bolus_after | dose_iv_bolus_after | none
conc_dose_iv_bolus_after | output_only | conc_dose_iv_bolus_after
conc_dose_iv_bolus_after | output_only | dose_iv_bolus_after
dose | conc_dose_iv_bolus_after | conc_dose_iv_bolus_after
dose | conc_dose_iv_bolus_after | dose_iv_bolus_after
dose | dose_iv_bolus_after | conc_dose_iv_bolus_after
dose | dose_iv_bolus_after | dose_iv_bolus_after
dose | output_only | conc_dose_iv_bolus_after
dose | output_only | dose_iv_bolus_after
dose_iv_bolus_after | conc_dose_iv_bolus_after | conc
dose_iv_bolus_after | conc_dose_iv_bolus_after | conc_dose
dose_iv_bolus_after | conc_dose_iv_bolus_after | conc_dose_iv_bolus_after
dose_iv_bolus_after | conc_dose_iv_bolus_after | dose
dose_iv_bolus_after | conc_dose_iv_bolus_after | dose_iv_bolus_after
dose_iv_bolus_after | conc_dose_iv_bolus_after | none
dose_iv_bolus_after | dose_iv_bolus_after | conc
dose_iv_bolus_after | dose_iv_bolus_after | conc_dose
dose_iv_bolus_after | dose_iv_bolus_after | conc_dose_iv_bolus_after
dose_iv_bolus_after | dose_iv_bolus_after | dose
dose_iv_bolus_after | dose_iv_bolus_after | dose_iv_bolus_after
dose_iv_bolus_after | dose_iv_bolus_after | none
dose_iv_bolus_after | output_only | conc_dose_iv_bolus_after
dose_iv_bolus_after | output_only | dose_iv_bolus_after
none | conc_dose_iv_bolus_after | conc_dose_iv_bolus_after
none | conc_dose_iv_bolus_after | dose_iv_bolus_after
none | dose_iv_bolus_after | conc_dose_iv_bolus_after
none | dose_iv_bolus_after | dose_iv_bolus_after
none | output_only | conc_dose_iv_bolus_after
none | output_only | dose_iv_bolus_after

## Doses with no concentrations between

Two doses with no concentrations between them, return NA.

Event Before | Event At | Event After
--- | --- | ---
conc_dose | dose | conc
conc_dose | dose | conc_dose
conc_dose | dose | conc_dose_iv_bolus_after
conc_dose | dose | dose
conc_dose | dose | dose_iv_bolus_after
conc_dose | dose | none
conc_dose | output_only | conc_dose
conc_dose | output_only | dose
dose | dose | conc
dose | dose | conc_dose
dose | dose | conc_dose_iv_bolus_after
dose | dose | dose
dose | dose | dose_iv_bolus_after
dose | dose | none
dose | output_only | conc_dose
dose | output_only | dose

## Extrapolation

Extrapolate from a concentration to a dose

Event Before | Event At | Event After
--- | --- | ---
conc | dose | conc
conc | dose | conc_dose
conc | dose | conc_dose_iv_bolus_after
conc | dose | dose
conc | dose | dose_iv_bolus_after
conc | dose | none
conc | output_only | dose
conc | output_only | none
conc_dose_iv_bolus_after | dose | conc
conc_dose_iv_bolus_after | dose | conc_dose
conc_dose_iv_bolus_after | dose | conc_dose_iv_bolus_after
conc_dose_iv_bolus_after | dose | dose
conc_dose_iv_bolus_after | dose | dose_iv_bolus_after
conc_dose_iv_bolus_after | dose | none
conc_dose_iv_bolus_after | output_only | dose
conc_dose_iv_bolus_after | output_only | none

## Immediately after an IV bolus without a concentration next

Cannot calculate C0 without a concentration after an IV bolus; return NA.

Event Before | Event At | Event After
--- | --- | ---
conc | dose_iv_bolus_after | dose
conc | dose_iv_bolus_after | none
conc_dose | dose_iv_bolus_after | dose
conc_dose | dose_iv_bolus_after | none
dose | dose_iv_bolus_after | dose
dose | dose_iv_bolus_after | none
dose_iv_bolus_after | dose | conc
dose_iv_bolus_after | dose | conc_dose
dose_iv_bolus_after | dose | conc_dose_iv_bolus_after
dose_iv_bolus_after | dose | dose
dose_iv_bolus_after | dose | dose_iv_bolus_after
dose_iv_bolus_after | dose | none
none | dose_iv_bolus_after | dose
none | dose_iv_bolus_after | none

## Before all events

Interpolation before any events is NA or zero (0) depending on the value of conc.origin. conc.origin defaults to zero which is the implicit assumption that a complete washout occurred and there is no endogenous source of the analyte.

Event Before | Event At | Event After
--- | --- | ---
none | dose | conc
none | dose | conc_dose
none | dose | conc_dose_iv_bolus_after
none | dose | dose
none | dose | dose_iv_bolus_after
none | dose | none
none | output_only | conc
none | output_only | conc_dose
none | output_only | dose
none | output_only | none

## Immediately after an IV bolus with a concentration next

Calculate C0 for the time immediately after an IV bolus. First, attempt using log slope back-extrapolation. If that fails, use the first concentration after the dose as C0.

Event Before | Event At | Event After
--- | --- | ---
conc | dose_iv_bolus_after | conc
conc | dose_iv_bolus_after | conc_dose
conc_dose | dose_iv_bolus_after | conc
conc_dose | dose_iv_bolus_after | conc_dose
dose | dose_iv_bolus_after | conc
dose | dose_iv_bolus_after | conc_dose
none | dose_iv_bolus_after | conc
none | dose_iv_bolus_after | conc_dose

## Interpolation

With concentrations before and after and not an IV bolus before, interpolate between observed concentrations.

Event Before | Event At | Event After
--- | --- | ---
conc | output_only | conc
conc | output_only | conc_dose
conc_dose | output_only | conc
conc_dose_iv_bolus_after | output_only | conc
conc_dose_iv_bolus_after | output_only | conc_dose

## After an IV bolus with a concentration next

First, calculate C0 using log slope back-extrapolation (falling back to the first post-dose concentration if that fails). Then, interpolate between C0 and the first post-dose concentration.

Event Before | Event At | Event After
--- | --- | ---
dose_iv_bolus_after | output_only | conc
dose_iv_bolus_after | output_only | conc_dose

## After an IV bolus without a concentration next

Between an IV bolus and anything other than a concentration, interpolation cannot occur. Return NA

Event Before | Event At | Event After
--- | --- | ---
dose_iv_bolus_after | output_only | dose
dose_iv_bolus_after | output_only | none

## Dose as the last event in the timeline and requesting a concentration after

Cannot estimate the concentration after a dose without concentrations after the dose, return NA.

Event Before | Event At | Event After
--- | --- | ---
conc_dose | output_only | none
dose | output_only | none

## Dose before, concentration after without a dose

If the concentration at the dose is estimable, interpolate. Otherwise, NA.

Event Before | Event At | Event After
--- | --- | ---
dose | output_only | conc

# Appendix: Complete Methods Table

Event Before | Event At | Event After | Method Used
--- | --- | --- | ---
conc | conc | conc | Observed concentration
conc | conc | conc_dose | Observed concentration
conc | conc | conc_dose_iv_bolus_after | Observed concentration
conc | conc | dose | Observed concentration
conc | conc | dose_iv_bolus_after | Observed concentration
conc | conc | none | Observed concentration
conc | conc_dose | conc | Observed concentration
conc | conc_dose | conc_dose | Observed concentration
conc | conc_dose | conc_dose_iv_bolus_after | Observed concentration
conc | conc_dose | dose | Observed concentration
conc | conc_dose | dose_iv_bolus_after | Observed concentration
conc | conc_dose | none | Observed concentration
conc | conc_dose_iv_bolus_after | conc | Observed concentration
conc | conc_dose_iv_bolus_after | conc_dose | Observed concentration
conc | conc_dose_iv_bolus_after | conc_dose_iv_bolus_after | Impossible combinations
conc | conc_dose_iv_bolus_after | dose | Observed concentration
conc | conc_dose_iv_bolus_after | dose_iv_bolus_after | Impossible combinations
conc | conc_dose_iv_bolus_after | none | Observed concentration
conc | dose | conc | Extrapolation
conc | dose | conc_dose | Extrapolation
conc | dose | conc_dose_iv_bolus_after | Extrapolation
conc | dose | dose | Extrapolation
conc | dose | dose_iv_bolus_after | Extrapolation
conc | dose | none | Extrapolation
conc | dose_iv_bolus_after | conc | Immediately after an IV bolus with a concentration next
conc | dose_iv_bolus_after | conc_dose | Immediately after an IV bolus with a concentration next
conc | dose_iv_bolus_after | conc_dose_iv_bolus_after | Impossible combinations
conc | dose_iv_bolus_after | dose | Immediately after an IV bolus without a concentration next
conc | dose_iv_bolus_after | dose_iv_bolus_after | Impossible combinations
conc | dose_iv_bolus_after | none | Immediately after an IV bolus without a concentration next
conc | output_only | conc | Interpolation
conc | output_only | conc_dose | Interpolation
conc | output_only | conc_dose_iv_bolus_after | Impossible combinations
conc | output_only | dose | Extrapolation
conc | output_only | dose_iv_bolus_after | Impossible combinations
conc | output_only | none | Extrapolation
conc_dose | conc | conc | Observed concentration
conc_dose | conc | conc_dose | Observed concentration
conc_dose | conc | conc_dose_iv_bolus_after | Observed concentration
conc_dose | conc | dose | Observed concentration
conc_dose | conc | dose_iv_bolus_after | Observed concentration
conc_dose | conc | none | Observed concentration
conc_dose | conc_dose | conc | Observed concentration
conc_dose | conc_dose | conc_dose | Observed concentration
conc_dose | conc_dose | conc_dose_iv_bolus_after | Observed concentration
conc_dose | conc_dose | dose | Observed concentration
conc_dose | conc_dose | dose_iv_bolus_after | Observed concentration
conc_dose | conc_dose | none | Observed concentration
conc_dose | conc_dose_iv_bolus_after | conc | Observed concentration
conc_dose | conc_dose_iv_bolus_after | conc_dose | Observed concentration
conc_dose | conc_dose_iv_bolus_after | conc_dose_iv_bolus_after | Impossible combinations
conc_dose | conc_dose_iv_bolus_after | dose | Observed concentration
conc_dose | conc_dose_iv_bolus_after | dose_iv_bolus_after | Impossible combinations
conc_dose | conc_dose_iv_bolus_after | none | Observed concentration
conc_dose | dose | conc | Doses with no concentrations between
conc_dose | dose | conc_dose | Doses with no concentrations between
conc_dose | dose | conc_dose_iv_bolus_after | Doses with no concentrations between
conc_dose | dose | dose | Doses with no concentrations between
conc_dose | dose | dose_iv_bolus_after | Doses with no concentrations between
conc_dose | dose | none | Doses with no concentrations between
conc_dose | dose_iv_bolus_after | conc | Immediately after an IV bolus with a concentration next
conc_dose | dose_iv_bolus_after | conc_dose | Immediately after an IV bolus with a concentration next
conc_dose | dose_iv_bolus_after | conc_dose_iv_bolus_after | Impossible combinations
conc_dose | dose_iv_bolus_after | dose | Immediately after an IV bolus without a concentration next
conc_dose | dose_iv_bolus_after | dose_iv_bolus_after | Impossible combinations
conc_dose | dose_iv_bolus_after | none | Immediately after an IV bolus without a concentration next
conc_dose | output_only | conc | Interpolation
conc_dose | output_only | conc_dose | Doses with no concentrations between
conc_dose | output_only | conc_dose_iv_bolus_after | Impossible combinations
conc_dose | output_only | dose | Doses with no concentrations between
conc_dose | output_only | dose_iv_bolus_after | Impossible combinations
conc_dose | output_only | none | Dose as the last event in the timeline and requesting a concentration after
conc_dose_iv_bolus_after | conc | conc | Observed concentration
conc_dose_iv_bolus_after | conc | conc_dose | Observed concentration
conc_dose_iv_bolus_after | conc | conc_dose_iv_bolus_after | Observed concentration
conc_dose_iv_bolus_after | conc | dose | Observed concentration
conc_dose_iv_bolus_after | conc | dose_iv_bolus_after | Observed concentration
conc_dose_iv_bolus_after | conc | none | Observed concentration
conc_dose_iv_bolus_after | conc_dose | conc | Observed concentration
conc_dose_iv_bolus_after | conc_dose | conc_dose | Observed concentration
conc_dose_iv_bolus_after | conc_dose | conc_dose_iv_bolus_after | Observed concentration
conc_dose_iv_bolus_after | conc_dose | dose | Observed concentration
conc_dose_iv_bolus_after | conc_dose | dose_iv_bolus_after | Observed concentration
conc_dose_iv_bolus_after | conc_dose | none | Observed concentration
conc_dose_iv_bolus_after | conc_dose_iv_bolus_after | conc | Impossible combinations
conc_dose_iv_bolus_after | conc_dose_iv_bolus_after | conc_dose | Impossible combinations
conc_dose_iv_bolus_after | conc_dose_iv_bolus_after | conc_dose_iv_bolus_after | Impossible combinations
conc_dose_iv_bolus_after | conc_dose_iv_bolus_after | dose | Impossible combinations
conc_dose_iv_bolus_after | conc_dose_iv_bolus_after | dose_iv_bolus_after | Impossible combinations
conc_dose_iv_bolus_after | conc_dose_iv_bolus_after | none | Impossible combinations
conc_dose_iv_bolus_after | dose | conc | Extrapolation
conc_dose_iv_bolus_after | dose | conc_dose | Extrapolation
conc_dose_iv_bolus_after | dose | conc_dose_iv_bolus_after | Extrapolation
conc_dose_iv_bolus_after | dose | dose | Extrapolation
conc_dose_iv_bolus_after | dose | dose_iv_bolus_after | Extrapolation
conc_dose_iv_bolus_after | dose | none | Extrapolation
conc_dose_iv_bolus_after | dose_iv_bolus_after | conc | Impossible combinations
conc_dose_iv_bolus_after | dose_iv_bolus_after | conc_dose | Impossible combinations
conc_dose_iv_bolus_after | dose_iv_bolus_after | conc_dose_iv_bolus_after | Impossible combinations
conc_dose_iv_bolus_after | dose_iv_bolus_after | dose | Impossible combinations
conc_dose_iv_bolus_after | dose_iv_bolus_after | dose_iv_bolus_after | Impossible combinations
conc_dose_iv_bolus_after | dose_iv_bolus_after | none | Impossible combinations
conc_dose_iv_bolus_after | output_only | conc | Interpolation
conc_dose_iv_bolus_after | output_only | conc_dose | Interpolation
conc_dose_iv_bolus_after | output_only | conc_dose_iv_bolus_after | Impossible combinations
conc_dose_iv_bolus_after | output_only | dose | Extrapolation
conc_dose_iv_bolus_after | output_only | dose_iv_bolus_after | Impossible combinations
conc_dose_iv_bolus_after | output_only | none | Extrapolation
dose | conc | conc | Observed concentration
dose | conc | conc_dose | Observed concentration
dose | conc | conc_dose_iv_bolus_after | Observed concentration
dose | conc | dose | Observed concentration
dose | conc | dose_iv_bolus_after | Observed concentration
dose | conc | none | Observed concentration
dose | conc_dose | conc | Observed concentration
dose | conc_dose | conc_dose | Observed concentration
dose | conc_dose | conc_dose_iv_bolus_after | Observed concentration
dose | conc_dose | dose | Observed concentration
dose | conc_dose | dose_iv_bolus_after | Observed concentration
dose | conc_dose | none | Observed concentration
dose | conc_dose_iv_bolus_after | conc | Observed concentration
dose | conc_dose_iv_bolus_after | conc_dose | Observed concentration
dose | conc_dose_iv_bolus_after | conc_dose_iv_bolus_after | Impossible combinations
dose | conc_dose_iv_bolus_after | dose | Observed concentration
dose | conc_dose_iv_bolus_after | dose_iv_bolus_after | Impossible combinations
dose | conc_dose_iv_bolus_after | none | Observed concentration
dose | dose | conc | Doses with no concentrations between
dose | dose | conc_dose | Doses with no concentrations between
dose | dose | conc_dose_iv_bolus_after | Doses with no concentrations between
dose | dose | dose | Doses with no concentrations between
dose | dose | dose_iv_bolus_after | Doses with no concentrations between
dose | dose | none | Doses with no concentrations between
dose | dose_iv_bolus_after | conc | Immediately after an IV bolus with a concentration next
dose | dose_iv_bolus_after | conc_dose | Immediately after an IV bolus with a concentration next
dose | dose_iv_bolus_after | conc_dose_iv_bolus_after | Impossible combinations
dose | dose_iv_bolus_after | dose | Immediately after an IV bolus without a concentration next
dose | dose_iv_bolus_after | dose_iv_bolus_after | Impossible combinations
dose | dose_iv_bolus_after | none | Immediately after an IV bolus without a concentration next
dose | output_only | conc | Dose before, concentration after without a dose
dose | output_only | conc_dose | Doses with no concentrations between
dose | output_only | conc_dose_iv_bolus_after | Impossible combinations
dose | output_only | dose | Doses with no concentrations between
dose | output_only | dose_iv_bolus_after | Impossible combinations
dose | output_only | none | Dose as the last event in the timeline and requesting a concentration after
dose_iv_bolus_after | conc | conc | Observed concentration
dose_iv_bolus_after | conc | conc_dose | Observed concentration
dose_iv_bolus_after | conc | conc_dose_iv_bolus_after | Observed concentration
dose_iv_bolus_after | conc | dose | Observed concentration
dose_iv_bolus_after | conc | dose_iv_bolus_after | Observed concentration
dose_iv_bolus_after | conc | none | Observed concentration
dose_iv_bolus_after | conc_dose | conc | Observed concentration
dose_iv_bolus_after | conc_dose | conc_dose | Observed concentration
dose_iv_bolus_after | conc_dose | conc_dose_iv_bolus_after | Observed concentration
dose_iv_bolus_after | conc_dose | dose | Observed concentration
dose_iv_bolus_after | conc_dose | dose_iv_bolus_after | Observed concentration
dose_iv_bolus_after | conc_dose | none | Observed concentration
dose_iv_bolus_after | conc_dose_iv_bolus_after | conc | Impossible combinations
dose_iv_bolus_after | conc_dose_iv_bolus_after | conc_dose | Impossible combinations
dose_iv_bolus_after | conc_dose_iv_bolus_after | conc_dose_iv_bolus_after | Impossible combinations
dose_iv_bolus_after | conc_dose_iv_bolus_after | dose | Impossible combinations
dose_iv_bolus_after | conc_dose_iv_bolus_after | dose_iv_bolus_after | Impossible combinations
dose_iv_bolus_after | conc_dose_iv_bolus_after | none | Impossible combinations
dose_iv_bolus_after | dose | conc | Immediately after an IV bolus without a concentration next
dose_iv_bolus_after | dose | conc_dose | Immediately after an IV bolus without a concentration next
dose_iv_bolus_after | dose | conc_dose_iv_bolus_after | Immediately after an IV bolus without a concentration next
dose_iv_bolus_after | dose | dose | Immediately after an IV bolus without a concentration next
dose_iv_bolus_after | dose | dose_iv_bolus_after | Immediately after an IV bolus without a concentration next
dose_iv_bolus_after | dose | none | Immediately after an IV bolus without a concentration next
dose_iv_bolus_after | dose_iv_bolus_after | conc | Impossible combinations
dose_iv_bolus_after | dose_iv_bolus_after | conc_dose | Impossible combinations
dose_iv_bolus_after | dose_iv_bolus_after | conc_dose_iv_bolus_after | Impossible combinations
dose_iv_bolus_after | dose_iv_bolus_after | dose | Impossible combinations
dose_iv_bolus_after | dose_iv_bolus_after | dose_iv_bolus_after | Impossible combinations
dose_iv_bolus_after | dose_iv_bolus_after | none | Impossible combinations
dose_iv_bolus_after | output_only | conc | After an IV bolus with a concentration next
dose_iv_bolus_after | output_only | conc_dose | After an IV bolus with a concentration next
dose_iv_bolus_after | output_only | conc_dose_iv_bolus_after | Impossible combinations
dose_iv_bolus_after | output_only | dose | After an IV bolus without a concentration next
dose_iv_bolus_after | output_only | dose_iv_bolus_after | Impossible combinations
dose_iv_bolus_after | output_only | none | After an IV bolus without a concentration next
none | conc | conc | Observed concentration
none | conc | conc_dose | Observed concentration
none | conc | conc_dose_iv_bolus_after | Observed concentration
none | conc | dose | Observed concentration
none | conc | dose_iv_bolus_after | Observed concentration
none | conc | none | Observed concentration
none | conc_dose | conc | Observed concentration
none | conc_dose | conc_dose | Observed concentration
none | conc_dose | conc_dose_iv_bolus_after | Observed concentration
none | conc_dose | dose | Observed concentration
none | conc_dose | dose_iv_bolus_after | Observed concentration
none | conc_dose | none | Observed concentration
none | conc_dose_iv_bolus_after | conc | Observed concentration
none | conc_dose_iv_bolus_after | conc_dose | Observed concentration
none | conc_dose_iv_bolus_after | conc_dose_iv_bolus_after | Impossible combinations
none | conc_dose_iv_bolus_after | dose | Observed concentration
none | conc_dose_iv_bolus_after | dose_iv_bolus_after | Impossible combinations
none | conc_dose_iv_bolus_after | none | Observed concentration
none | dose | conc | Before all events
none | dose | conc_dose | Before all events
none | dose | conc_dose_iv_bolus_after | Before all events
none | dose | dose | Before all events
none | dose | dose_iv_bolus_after | Before all events
none | dose | none | Before all events
none | dose_iv_bolus_after | conc | Immediately after an IV bolus with a concentration next
none | dose_iv_bolus_after | conc_dose | Immediately after an IV bolus with a concentration next
none | dose_iv_bolus_after | conc_dose_iv_bolus_after | Impossible combinations
none | dose_iv_bolus_after | dose | Immediately after an IV bolus without a concentration next
none | dose_iv_bolus_after | dose_iv_bolus_after | Impossible combinations
none | dose_iv_bolus_after | none | Immediately after an IV bolus without a concentration next
none | output_only | conc | Before all events
none | output_only | conc_dose | Before all events
none | output_only | conc_dose_iv_bolus_after | Impossible combinations
none | output_only | dose | Before all events
none | output_only | dose_iv_bolus_after | Impossible combinations
none | output_only | none | Before all events