Package: ToxCrit
Type: Package
Title: Calculates Safety Stopping Boundaries for a Single-Arm Trial
        using Bayes
Version: 1.1
Authors@R: c(person("NCT Trial Center, Heidelberg", 
    email = "studienzentrale@nct-heidelberg.de", 
    role = c("aut")), 
    person("Lisa-Marie Lanz", 
    email="studienzentrale@nct-heidelberg.de", 
    role="cre"))
Author: NCT Trial Center, Heidelberg [aut],
  Lisa-Marie Lanz [cre]
Maintainer: Lisa-Marie Lanz <studienzentrale@nct-heidelberg.de>
Description: Computation of stopping boundaries for a single-arm trial using a 
    Bayesian criterion. For each m<=n (n=total patient number of the 
    trial) the smallest number of observed toxicities is calculated leading
    to the termination of the trial/accrual according to the specified criteria.
    The probabilities of stopping the trial/accrual at and up until (resp.) the
    m-th patient (m<=n) is also calculated. This design is more conservative than 
    the frequentist approach (using Clopper Pearson CIs) which might be preferred
    as it concerns safety. See also Aamot et al. (2010) "Continuous monitoring of 
    toxicity in clinical Trials - simulating the risk of stopping prematurely" 
    <doi:10.5414/cpp48476>.
License: GPL-3
Encoding: UTF-8
RoxygenNote: 7.3.3
NeedsCompilation: no
Packaged: 2026-03-04 10:15:16 UTC; Lisa
Repository: CRAN
Date/Publication: 2026-03-05 08:10:19 UTC
Built: R 4.6.0; ; 2026-04-25 13:03:43 UTC; unix
