Augment_Missing         Augment missing response with observed
                        information
Comp_Hess               Compute analytical form of Hessian matrix of
                        Binary Emax model
Comp_I                  Compute analytical form of expected information
                        matrix of Binary Emax model
comp_Q                  Maximization function estimation of EM
                        algorithm with defined weight.
comp_Q_firth            Maximization function estimation of bias
                        reduced EM algorithm with defined weight.
comp_theta              Estimation of emax parameters in EM algorithm
                        iteration.
comp_theta_cox_snell    Cox–Snell bias-corrected estimator (one-step
                        using 'clinDR' MLE)
comp_theta_firth        Estimation of emax parameters in Jeffery's
                        prior penalized IL algorithm iteration.
comp_theta_firth_score
                        Firth-corrected estimating equation solution
                        (score-based)
comp_theta_jeffrey      Jeffreys-penalized likelihood estimator via
                        Newton–Raphson
comp_vcov               Calculate the variance covariance matrix of
                        estimated parameters by EmaxEM
comp_vcov_firth         Calculate the variance covariance matrix of
                        estimated parameters by EmaxEM_firth
comp_weight             Estimation of working weight in EM algorithm
                        iteration.
fitEmaxEM               Fitting IL method with Emax model and binary
                        response missing data.
fitEmaxEM_firth         Fitting bias reduced IL method with Emax model
                        and binary response missing data.
log_Emax_i              Log likelihood estimation of binary Emax model
log_missing_i           Log likelihood estimation of logisitic missing
                        indicator model
sim_data                Simulate dataset for testing Emaxem and
                        Emaxem_firth
