Package: GMAC
Type: Package
Title: Genomic Mediation Analysis with Adaptive Confounding Adjustment
Version: 3.2
Date: 2025-12-9
Author: Fan Yang [aut],
  Jiebiao Wang [aut, cre],
  Lin Chen [aut]
Authors@R: c(person(given = "Fan",
                        family = "Yang",
                        role = "aut"),
                 person(given = "Jiebiao",
                        family = "Wang",
                        role = c("aut", "cre"),
                        email = "randel.wang@gmail.com"),
                 person(given = "Lin",
                        family = "Chen",
                        role = "aut"))
Maintainer: Jiebiao Wang <randel.wang@gmail.com>
Description: Performs genomic mediation
    analysis with adaptive confounding adjustment (GMAC) proposed by Yang et al. (2017) <doi:10.1101/gr.216754.116>. It implements large scale
    mediation analysis and adaptively selects potential confounding variables to
    adjust for each mediation test from a pool of candidate confounders. The package
    is tailored for but not limited to genomic mediation analysis (e.g., cis-gene
    mediating trans-gene regulation pattern where an eQTL, its cis-linking gene
    transcript, and its trans-gene transcript play the roles as treatment, mediator
    and the outcome, respectively), restricting to scenarios with the presence of
    cis-association (i.e., treatment-mediator association) and random eQTL (i.e.,
    treatment).
License: GPL
Depends: parallel
LazyData: TRUE
NeedsCompilation: no
Repository: CRAN
RoxygenNote: 7.3.2
Packaged: 2025-12-11 17:35:02 UTC; jbwang
Date/Publication: 2025-12-11 19:10:02 UTC
Built: R 4.6.0; ; 2026-04-25 19:18:24 UTC; unix
