Package: GxEprs
Title: Genotype-by-Environment Interaction in Polygenic Score Models
Version: 1.2
Authors@R: c(person("Dovini", "Jayasinghe", role = c("aut", "cre","cph"), email = "dovini.jayasinghe@mymail.unisa.edu.au"),
             person("Hong", "Lee", role = c("aut","cph"),email = "Hong.Lee@unisa.edu.au"),
             person("Moksedul", "Momin", role = c("aut","cph"), email = "md_moksedul.momin@mymail.unisa.edu.au"))
Description: A novel PRS model is introduced to enhance the prediction accuracy by utilising GxE effects. This package performs Genome Wide Association Studies (GWAS) and Genome Wide Environment Interaction Studies (GWEIS) using a discovery dataset. The package has the ability to obtain polygenic risk scores (PRSs) for a target sample. Finally it predicts the risk values of each individual in the target sample. Users have the choice of using existing models (Li et al., 2015) <doi:10.1093/annonc/mdu565>, (Pandis et al., 2013) <doi:10.1093/ejo/cjt054>, (Peyrot et al., 2018) <doi:10.1016/j.biopsych.2017.09.009> and (Song et al., 2022) <doi:10.1038/s41467-022-32407-9>, as well as newly proposed models for genomic risk prediction (refer to the URL for more details).
URL: https://github.com/DoviniJ/GxEprs
License: GPL (>= 3)
Encoding: UTF-8
RoxygenNote: 7.3.1
Depends: R (>= 2.10)
LazyData: true
NeedsCompilation: no
Packaged: 2024-05-29 04:24:11 UTC; jaydy007
Author: Dovini Jayasinghe [aut, cre, cph],
  Hong Lee [aut, cph],
  Moksedul Momin [aut, cph]
Maintainer: Dovini Jayasinghe <dovini.jayasinghe@mymail.unisa.edu.au>
Repository: CRAN
Date/Publication: 2024-05-29 23:50:07 UTC
Built: R 4.6.0; ; 2026-04-25 19:26:37 UTC; unix
