Mon 06 Feb 2023 02:32:47 PM CET
$PROBLEM //like/2001//but/1 cmt, diag. omega, prop. err.//
$INPUT C ID TIME SEQ=DROP EVID AMT DV SUBJ HOUR HEIGHT WT SEX AGE DOSE FED
$DATA ../../data/derived/drug.csv IGNORE=C
$SUBROUTINE ADVAN2 TRANS2
$PK
 CL=THETA(1)*EXP(ETA(1))
 V =THETA(2)*EXP(ETA(2))
 KA=THETA(3)*EXP(ETA(3))
 S2=V
 
$ERROR
 Y=F*(1+ERR(1))
 IPRE=F

$THETA
(0,10,50)                       ; CL/F     ; clearance                                     ; L/h                    
(0,10,100)                      ; Vc/F     ; central volume                                ; L                      
(0,0.2,5)                       ; Ka       ; absorption rate constant                      ; 1/h                    

$OMEGA                      
0.1                             ; IIV_CL   ; interindividual variability on clearance     
0.1                             ; IIV_Vc   ; interindividual variability on central volume
0.1                             ; IIV_Ka   ; interindividual variability on Ka            

$SIGMA
0.1                             ; ERR_PROP ; proportional error                           

$ESTIMATION MAXEVAL=9999 PRINT=5 NOABORT METHOD=1 INTER MSFO=mod.msf
$COV PRINT=E
$TABLE NOPRINT FILE=mod.tab ONEHEADER
ID                              ; ID       ; NONMEM subject identifier                    
AMT                             ; AMT      ; dose amount                                   ; mg                     
TIME                            ; TIME     ; time                                          ; h                      
EVID                            ; EVID     ; event type                                    ; //0/observation//1/dose
PRED                            ; PRED     ; population prediction                         ; ng/mL                  
IPRE                            ; IPRED    ; individual prediction                         ; ng/mL                  
CWRESI                          ; CWRESI   ; conditional weighted residual                
CIWRESI                         ; CIWRESI  ; conditional indvividual weighted residual    

$TABLE NOPRINT FILE=mod2.tab ONEHEADER
ID                              ; ID       ; NONMEM subject identifier                    
TIME                            ; TIME     ; time                                          ; h                      
CL                              ; CLI      ; posthoc systemic clearance                    ; L/h                    
V                               ; V2I      ; posthoc systemic volume                       ; L                      
KA                              ; KAI      ; posthoc absorption rate                       ; 1/h                    
ETA1                            ; BSV_CL   ; clearance between-subject variability        
ETA2                            ; BSV_V2   ; volume between-subject variability           
ETA3                            ; BSV_KA   ; absorption between-subject variability       

NM-TRAN MESSAGES
  
 WARNINGS AND ERRORS (IF ANY) FOR PROBLEM    1
             
 (WARNING  2) NM-TRAN INFERS THAT THE DATA ARE POPULATION.

License Registered to: qPharmetra
Expiration Date:    14 JUL 2023
Current Date:        6 FEB 2023
Days until program expires : 158
1NONLINEAR MIXED EFFECTS MODEL PROGRAM (NONMEM) VERSION 7.4.3
 ORIGINALLY DEVELOPED BY STUART BEAL, LEWIS SHEINER, AND ALISON BOECKMANN
 CURRENT DEVELOPERS ARE ROBERT BAUER, ICON DEVELOPMENT SOLUTIONS,
 AND ALISON BOECKMANN. IMPLEMENTATION, EFFICIENCY, AND STANDARDIZATION
 PERFORMED BY NOUS INFOSYSTEMS.

 PROBLEM NO.:         1
 //like/2001//but/1 cmt, diag. omega, prop. err.//
0DATA CHECKOUT RUN:              NO
 DATA SET LOCATED ON UNIT NO.:    2
 THIS UNIT TO BE REWOUND:        NO
 NO. OF DATA RECS IN DATA SET:      550
 NO. OF DATA ITEMS IN DATA SET:  15
 ID DATA ITEM IS DATA ITEM NO.:   2
 DEP VARIABLE IS DATA ITEM NO.:   6
 MDV DATA ITEM IS DATA ITEM NO.: 15
0INDICES PASSED TO SUBROUTINE PRED:
   4   3   5   0   0   0   0   0   0   0   0
0LABELS FOR DATA ITEMS:
 C ID TIME EVID AMT DV SUBJ HOUR HEIGHT WT SEX AGE DOSE FED MDV
0(NONBLANK) LABELS FOR PRED-DEFINED ITEMS:
 CL V KA IPRE
0FORMAT FOR DATA:
 (E2.0,E3.0,E5.0,E2.0,2E6.0,E3.0,E5.0,E4.0,E5.0,E2.0,E5.0,2E6.0,1F2.0)

 TOT. NO. OF OBS RECS:      510
 TOT. NO. OF INDIVIDUALS:       40
0LENGTH OF THETA:   3
0DEFAULT THETA BOUNDARY TEST OMITTED:    NO
0OMEGA HAS SIMPLE DIAGONAL FORM WITH DIMENSION:   3
0DEFAULT OMEGA BOUNDARY TEST OMITTED:    NO
0SIGMA HAS SIMPLE DIAGONAL FORM WITH DIMENSION:   1
0DEFAULT SIGMA BOUNDARY TEST OMITTED:    NO
0INITIAL ESTIMATE OF THETA:
 LOWER BOUND    INITIAL EST    UPPER BOUND
  0.0000E+00     0.1000E+02     0.5000E+02
  0.0000E+00     0.1000E+02     0.1000E+03
  0.0000E+00     0.2000E+00     0.5000E+01
0INITIAL ESTIMATE OF OMEGA:
 0.1000E+00
 0.0000E+00   0.1000E+00
 0.0000E+00   0.0000E+00   0.1000E+00
0INITIAL ESTIMATE OF SIGMA:
 0.1000E+00
0COVARIANCE STEP OMITTED:        NO
 EIGENVLS. PRINTED:             YES
 SPECIAL COMPUTATION:            NO
 COMPRESSED FORMAT:              NO
 GRADIENT METHOD USED:     NOSLOW
 SIGDIGITS ETAHAT (SIGLO):                  -1
 SIGDIGITS GRADIENTS (SIGL):                -1
 EXCLUDE COV FOR FOCE (NOFCOV):              NO
 TURN OFF Cholesky Transposition of R Matrix (CHOLROFF): NO
 KNUTHSUMOFF:                                -1
 RESUME COV ANALYSIS (RESUME):               NO
 SIR SAMPLE SIZE (SIRSAMPLE):              -1
 NON-LINEARLY TRANSFORM THETAS DURING COV (THBND): 1
 PRECONDTIONING CYCLES (PRECOND):        0
 PRECONDTIONING TYPES (PRECONDS):        TOS
 FORCED PRECONDTIONING CYCLES (PFCOND):0
 PRECONDTIONING TYPE (PRETYPE):        0
 FORCED POS. DEFINITE SETTING: (FPOSDEF):0
0TABLES STEP OMITTED:    NO
 NO. OF TABLES:           2
 SEED NUMBER (SEED):    11456
 RANMETHOD:             3U
 MC SAMPLES (ESAMPLE):    300
 WRES SQUARE ROOT TYPE (WRESCHOL): EIGENVALUE
0-- TABLE   1 --
0RECORDS ONLY:    ALL
04 COLUMNS APPENDED:    YES
 PRINTED:                NO
 HEADER:                YES
 FILE TO BE FORWARDED:   NO
 FORMAT:                S1PE11.4
 LFORMAT:
 RFORMAT:
 FIXED_EFFECT_ETAS:
0USER-CHOSEN ITEMS:
 ID AMT TIME EVID IPRE CWRESI CIWRESI
0-- TABLE   2 --
0RECORDS ONLY:    ALL
04 COLUMNS APPENDED:    YES
 PRINTED:                NO
 HEADER:                YES
 FILE TO BE FORWARDED:   NO
 FORMAT:                S1PE11.4
 LFORMAT:
 RFORMAT:
 FIXED_EFFECT_ETAS:
0USER-CHOSEN ITEMS:
 ID TIME CL V KA ETA1 ETA2 ETA3
1DOUBLE PRECISION PREDPP VERSION 7.4.3

 ONE COMPARTMENT MODEL WITH FIRST-ORDER ABSORPTION (ADVAN2)
0MAXIMUM NO. OF BASIC PK PARAMETERS:   3
0BASIC PK PARAMETERS (AFTER TRANSLATION):
   ELIMINATION RATE (K) IS BASIC PK PARAMETER NO.:  1
   ABSORPTION RATE (KA) IS BASIC PK PARAMETER NO.:  3

 TRANSLATOR WILL CONVERT PARAMETERS
 CLEARANCE (CL) AND VOLUME (V) TO K (TRANS2)
0COMPARTMENT ATTRIBUTES
 COMPT. NO.   FUNCTION   INITIAL    ON/OFF      DOSE      DEFAULT    DEFAULT
                         STATUS     ALLOWED    ALLOWED    FOR DOSE   FOR OBS.
    1         DEPOT        OFF        YES        YES        YES        NO
    2         CENTRAL      ON         NO         YES        NO         YES
    3         OUTPUT       OFF        YES        NO         NO         NO
1
 ADDITIONAL PK PARAMETERS - ASSIGNMENT OF ROWS IN GG
 COMPT. NO.                             INDICES
              SCALE      BIOAVAIL.   ZERO-ORDER  ZERO-ORDER  ABSORB
                         FRACTION    RATE        DURATION    LAG
    1            *           *           *           *           *
    2            4           *           *           *           *
    3            *           -           -           -           -
             - PARAMETER IS NOT ALLOWED FOR THIS MODEL
             * PARAMETER IS NOT SUPPLIED BY PK SUBROUTINE;
               WILL DEFAULT TO ONE IF APPLICABLE
0DATA ITEM INDICES USED BY PRED ARE:
   EVENT ID DATA ITEM IS DATA ITEM NO.:      4
   TIME DATA ITEM IS DATA ITEM NO.:          3
   DOSE AMOUNT DATA ITEM IS DATA ITEM NO.:   5

0PK SUBROUTINE CALLED WITH EVERY EVENT RECORD.
 PK SUBROUTINE NOT CALLED AT NONEVENT (ADDITIONAL OR LAGGED) DOSE TIMES.
0ERROR SUBROUTINE CALLED WITH EVERY EVENT RECORD.
1


 #TBLN:      1
 #METH: First Order Conditional Estimation with Interaction

 ESTIMATION STEP OMITTED:                 NO
 ANALYSIS TYPE:                           POPULATION
 NUMBER OF SADDLE POINT RESET ITERATIONS:      0
 GRADIENT METHOD USED:               NOSLOW
 CONDITIONAL ESTIMATES USED:              YES
 CENTERED ETA:                            NO
 EPS-ETA INTERACTION:                     YES
 LAPLACIAN OBJ. FUNC.:                    NO
 NO. OF FUNCT. EVALS. ALLOWED:            9999
 NO. OF SIG. FIGURES REQUIRED:            3
 INTERMEDIATE PRINTOUT:                   YES
 ESTIMATE OUTPUT TO MSF:                  YES
 ABORT WITH PRED EXIT CODE 1:             NO
 IND. OBJ. FUNC. VALUES SORTED:           NO
 NUMERICAL DERIVATIVE
       FILE REQUEST (NUMDER):               NONE
 MAP (ETAHAT) ESTIMATION METHOD (OPTMAP):   0
 ETA HESSIAN EVALUATION METHOD (ETADER):    0
 INITIAL ETA FOR MAP ESTIMATION (MCETA):    0
 SIGDIGITS FOR MAP ESTIMATION (SIGLO):      100
 GRADIENT SIGDIGITS OF
       FIXED EFFECTS PARAMETERS (SIGL):     100
 NOPRIOR SETTING (NOPRIOR):                 OFF
 NOCOV SETTING (NOCOV):                     OFF
 DERCONT SETTING (DERCONT):                 OFF
 FINAL ETA RE-EVALUATION (FNLETA):          ON
 EXCLUDE NON-INFLUENTIAL (NON-INFL.) ETAS
       IN SHRINKAGE (ETASTYPE):             NO
 NON-INFL. ETA CORRECTION (NONINFETA):      OFF
 RAW OUTPUT FILE (FILE): 2001.ext
 EXCLUDE TITLE (NOTITLE):                   NO
 EXCLUDE COLUMN LABELS (NOLABEL):           NO
 FORMAT FOR ADDITIONAL FILES (FORMAT):      S1PE12.5
 PARAMETER ORDER FOR OUTPUTS (ORDER):       TSOL
 WISHART PRIOR DF INTERPRETATION (WISHTYPE):0
 KNUTHSUMOFF:                               0
 INCLUDE LNTWOPI:                           NO
 INCLUDE CONSTANT TERM TO PRIOR (PRIORC):   NO
 INCLUDE CONSTANT TERM TO OMEGA (ETA) (OLNTWOPI):NO
 ADDITIONAL CONVERGENCE TEST (CTYPE=4)?:    NO
 EM OR BAYESIAN METHOD USED:                 NONE


 THE FOLLOWING LABELS ARE EQUIVALENT
 PRED=PREDI
 RES=RESI
 WRES=WRESI
 IWRS=IWRESI
 IPRD=IPREDI
 IRS=IRESI

 MONITORING OF SEARCH:


0ITERATION NO.:    0    OBJECTIVE VALUE:   3526.64995298550        NO. OF FUNC. EVALS.:   6
 CUMULATIVE NO. OF FUNC. EVALS.:        6
 NPARAMETR:  1.0000E+01  1.0000E+01  2.0000E-01  1.0000E-01  1.0000E-01  1.0000E-01  1.0000E-01
 PARAMETER:  1.0000E-01  1.0000E-01  1.0000E-01  1.0000E-01  1.0000E-01  1.0000E-01  1.0000E-01
 GRADIENT:  -7.6264E+01 -1.8385E+02  1.1083E+03 -1.1913E+02 -6.3594E+01 -1.6276E+03  1.1865E+02

0ITERATION NO.:    5    OBJECTIVE VALUE:   2594.77112083027        NO. OF FUNC. EVALS.:  36
 CUMULATIVE NO. OF FUNC. EVALS.:       42
 NPARAMETR:  1.1366E+01  1.4373E+01  3.7031E-02  4.4153E-01  3.1162E-01  1.6441E-01  7.9058E-02
 PARAMETER:  2.6282E-01  5.1261E-01 -1.6199E+00  8.4254E-01  6.6830E-01  3.4861E-01 -1.7493E-02
 GRADIENT:   4.8130E+00  1.9090E+01 -5.9072E+01  3.2923E+01  1.4618E+01  2.8795E+01  4.2077E+01

0ITERATION NO.:   10    OBJECTIVE VALUE:   2579.09278791736        NO. OF FUNC. EVALS.:  37
 CUMULATIVE NO. OF FUNC. EVALS.:       79
 NPARAMETR:  1.1228E+01  1.2638E+01  4.1132E-02  2.4766E-01  2.0565E-01  1.3913E-01  7.1033E-02
 PARAMETER:  2.4697E-01  3.6388E-01 -1.5141E+00  5.5345E-01  4.6050E-01  2.6511E-01 -7.1011E-02
 GRADIENT:   6.2956E+00 -7.7919E+00 -1.2904E+01 -1.5552E+00 -3.5610E+00  3.3825E+01 -3.6043E+01

0ITERATION NO.:   15    OBJECTIVE VALUE:   2570.52455450746        NO. OF FUNC. EVALS.:  43
 CUMULATIVE NO. OF FUNC. EVALS.:      122
 NPARAMETR:  1.1039E+01  1.3111E+01  4.3229E-02  2.5249E-01  2.0564E-01  6.6874E-02  7.5276E-02
 PARAMETER:  2.2519E-01  4.0604E-01 -1.4640E+00  5.6310E-01  4.6047E-01 -1.0118E-01 -4.2007E-02
 GRADIENT:  -4.7137E-01 -1.8774E+00 -7.4553E+00  5.8548E-01 -6.1828E-01  1.1474E+00  1.8624E+00

0ITERATION NO.:   19    OBJECTIVE VALUE:   2570.47423039897        NO. OF FUNC. EVALS.:  49
 CUMULATIVE NO. OF FUNC. EVALS.:      171
 NPARAMETR:  1.1062E+01  1.3223E+01  4.3565E-02  2.5059E-01  2.0844E-01  6.5323E-02  7.5112E-02
 PARAMETER:  2.2785E-01  4.1585E-01 -1.4561E+00  5.5932E-01  4.6725E-01 -1.1292E-01 -4.3097E-02
 GRADIENT:  -2.7396E-03 -1.4497E-03  9.6923E-03  1.3233E-03 -4.0916E-04 -7.8650E-03 -1.2926E-02

 #TERM:
0MINIMIZATION SUCCESSFUL
 NO. OF FUNCTION EVALUATIONS USED:      171
 NO. OF SIG. DIGITS IN FINAL EST.:  3.2

 ETABAR IS THE ARITHMETIC MEAN OF THE ETA-ESTIMATES,
 AND THE P-VALUE IS GIVEN FOR THE NULL HYPOTHESIS THAT THE TRUE MEAN IS 0.

 ETABAR:         8.9838E-05  1.2106E-02  6.6160E-03
 SE:             7.7971E-02  6.4680E-02  3.7617E-02
 N:                      40          40          40

 P VAL.:         9.9908E-01  8.5153E-01  8.6039E-01

 ETASHRINKSD(%)  2.3423E-01  9.2591E+00  5.7284E+00
 ETASHRINKVR(%)  4.6790E-01  1.7661E+01  1.1129E+01
 EBVSHRINKSD(%)  1.5179E+00  1.0683E+01  6.5779E+00
 EBVSHRINKVR(%)  3.0128E+00  2.0224E+01  1.2723E+01
 EPSSHRINKSD(%)  9.4851E+00
 EPSSHRINKVR(%)  1.8070E+01

  
 TOTAL DATA POINTS NORMALLY DISTRIBUTED (N):          510
 N*LOG(2PI) CONSTANT TO OBJECTIVE FUNCTION:    937.31730386876609     
 OBJECTIVE FUNCTION VALUE WITHOUT CONSTANT:    2570.4742303989719     
 OBJECTIVE FUNCTION VALUE WITH CONSTANT:       3507.7915342677379     
 REPORTED OBJECTIVE FUNCTION DOES NOT CONTAIN CONSTANT
  
 TOTAL EFFECTIVE ETAS (NIND*NETA):                           120
  
 #TERE:
 Elapsed estimation  time in seconds:     0.75
 Elapsed covariance  time in seconds:     0.54
 Elapsed postprocess time in seconds:     0.02
1
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 ************************************************************************************************************************
 ********************                                                                                ********************
 ********************               FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION              ********************
 #OBJT:**************                       MINIMUM VALUE OF OBJECTIVE FUNCTION                      ********************
 ********************                                                                                ********************
 ************************************************************************************************************************
 





 #OBJV:********************************************     2570.474       **************************************************
1
 ************************************************************************************************************************
 ********************                                                                                ********************
 ********************               FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION              ********************
 ********************                             FINAL PARAMETER ESTIMATE                           ********************
 ********************                                                                                ********************
 ************************************************************************************************************************
 


 THETA - VECTOR OF FIXED EFFECTS PARAMETERS   *********


         TH 1      TH 2      TH 3     
 
         1.11E+01  1.32E+01  4.36E-02
 


 OMEGA - COV MATRIX FOR RANDOM EFFECTS - ETAS  ********


         ETA1      ETA2      ETA3     
 
 ETA1
+        2.51E-01
 
 ETA2
+        0.00E+00  2.08E-01
 
 ETA3
+        0.00E+00  0.00E+00  6.53E-02
 


 SIGMA - COV MATRIX FOR RANDOM EFFECTS - EPSILONS  ****


         EPS1     
 
 EPS1
+        7.51E-02
 
1


 OMEGA - CORR MATRIX FOR RANDOM EFFECTS - ETAS  *******


         ETA1      ETA2      ETA3     
 
 ETA1
+        5.01E-01
 
 ETA2
+        0.00E+00  4.57E-01
 
 ETA3
+        0.00E+00  0.00E+00  2.56E-01
 


 SIGMA - CORR MATRIX FOR RANDOM EFFECTS - EPSILONS  ***


         EPS1     
 
 EPS1
+        2.74E-01
 
1
 ************************************************************************************************************************
 ********************                                                                                ********************
 ********************               FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION              ********************
 ********************                            STANDARD ERROR OF ESTIMATE                          ********************
 ********************                                                                                ********************
 ************************************************************************************************************************
 


 THETA - VECTOR OF FIXED EFFECTS PARAMETERS   *********


         TH 1      TH 2      TH 3     
 
         9.03E-01  1.10E+00  2.00E-03
 


 OMEGA - COV MATRIX FOR RANDOM EFFECTS - ETAS  ********


         ETA1      ETA2      ETA3     
 
 ETA1
+        4.84E-02
 
 ETA2
+       .........  4.29E-02
 
 ETA3
+       ......... .........  1.90E-02
 


 SIGMA - COV MATRIX FOR RANDOM EFFECTS - EPSILONS  ****


         EPS1     
 
 EPS1
+        7.71E-03
 
1


 OMEGA - CORR MATRIX FOR RANDOM EFFECTS - ETAS  *******


         ETA1      ETA2      ETA3     
 
 ETA1
+        4.83E-02
 
 ETA2
+       .........  4.70E-02
 
 ETA3
+       ......... .........  3.73E-02
 


 SIGMA - CORR MATRIX FOR RANDOM EFFECTS - EPSILONS  ***


         EPS1     
 
 EPS1
+        1.41E-02
 
1
 ************************************************************************************************************************
 ********************                                                                                ********************
 ********************               FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION              ********************
 ********************                          COVARIANCE MATRIX OF ESTIMATE                         ********************
 ********************                                                                                ********************
 ************************************************************************************************************************
 

            TH 1      TH 2      TH 3      OM11      OM12      OM13      OM22      OM23      OM33      SG11  
 
 TH 1
+        8.16E-01
 
 TH 2
+        7.82E-01  1.21E+00
 
 TH 3
+        6.55E-04  8.56E-04  4.02E-06
 
 OM11
+        1.54E-02  1.55E-02  1.34E-05  2.34E-03
 
 OM12
+       ......... ......... ......... ......... .........
 
 OM13
+       ......... ......... ......... ......... ......... .........
 
 OM22
+        1.14E-02  1.17E-02  9.37E-07  1.14E-03 ......... .........  1.84E-03
 
 OM23
+       ......... ......... ......... ......... ......... ......... ......... .........
 
 OM33
+       -3.56E-03 -7.18E-03 -2.49E-05 -1.17E-04 ......... ......... -6.27E-05 .........  3.63E-04
 
 SG11
+        8.47E-04 -2.54E-03 -6.16E-06 -9.34E-05 ......... ......... -2.12E-05 .........  4.77E-05  5.94E-05
 
1
 ************************************************************************************************************************
 ********************                                                                                ********************
 ********************               FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION              ********************
 ********************                          CORRELATION MATRIX OF ESTIMATE                        ********************
 ********************                                                                                ********************
 ************************************************************************************************************************
 

            TH 1      TH 2      TH 3      OM11      OM12      OM13      OM22      OM23      OM33      SG11  
 
 TH 1
+        9.03E-01
 
 TH 2
+        7.87E-01  1.10E+00
 
 TH 3
+        3.62E-01  3.89E-01  2.00E-03
 
 OM11
+        3.52E-01  2.92E-01  1.38E-01  4.84E-02
 
 OM12
+       ......... ......... ......... ......... .........
 
 OM13
+       ......... ......... ......... ......... ......... .........
 
 OM22
+        2.94E-01  2.48E-01  1.09E-02  5.49E-01 ......... .........  4.29E-02
 
 OM23
+       ......... ......... ......... ......... ......... ......... ......... .........
 
 OM33
+       -2.07E-01 -3.43E-01 -6.52E-01 -1.27E-01 ......... ......... -7.67E-02 .........  1.90E-02
 
 SG11
+        1.22E-01 -3.00E-01 -3.99E-01 -2.50E-01 ......... ......... -6.41E-02 .........  3.25E-01  7.71E-03
 
1
 ************************************************************************************************************************
 ********************                                                                                ********************
 ********************               FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION              ********************
 ********************                      INVERSE COVARIANCE MATRIX OF ESTIMATE                     ********************
 ********************                                                                                ********************
 ************************************************************************************************************************
 

            TH 1      TH 2      TH 3      OM11      OM12      OM13      OM22      OM23      OM33      SG11  
 
 TH 1
+        8.11E+00
 
 TH 2
+       -5.30E+00  4.57E+00
 
 TH 3
+       -1.13E+03  5.87E+02  6.44E+05
 
 OM11
+       -3.11E+01  1.72E+01  3.66E+03  7.85E+02
 
 OM12
+       ......... ......... ......... ......... .........
 
 OM13
+       ......... ......... ......... ......... ......... .........
 
 OM22
+       -3.80E+00 -2.02E+00  2.83E+03 -3.70E+02 ......... .........  8.10E+02
 
 OM23
+       ......... ......... ......... ......... ......... ......... ......... .........
 
 OM33
+       -5.15E+01  4.09E+01  3.50E+04  1.40E+02 ......... .........  1.58E+02 .........  5.25E+03
 
 SG11
+       -4.68E+02  3.25E+02  8.67E+04  2.55E+03 ......... ......... -1.59E+02 .........  2.18E+03  4.86E+04
 
1
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 ************************************************************************************************************************
 ********************                                                                                ********************
 ********************               FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION              ********************
 ********************                      EIGENVALUES OF COR MATRIX OF ESTIMATE                     ********************
 ********************                                                                                ********************
 ************************************************************************************************************************
 

             1         2         3         4         5         6         7
 
         7.00E-02  3.36E-01  4.45E-01  6.89E-01  1.14E+00  1.52E+00  2.80E+00
 
 Elapsed finaloutput time in seconds:     0.02
 #CPUT: Total CPU Time in Seconds,        1.345
Stop Time:
Mon 06 Feb 2023 02:32:52 PM CET
