| bin_timepoints | Categorize Observed Timepoints According to Scheduled Timepoints |
| change_from_baseline | Calculate the Change from Baseline or Treatment Effects from Estimated Marginal Means |
| make_visit_labels | Make Visit Labels Based on a Numeric Vector |
| midpoints | Midpoints of a Numeric Vector |
| ncs_analysis | Run a Natural Cubic Spline (NCS) Analysis. |
| ncs_analysis_subgroup | Run a Natural Cubic Spline (NCS) Analysis. |
| ncs_emmeans | Estimate Marginal Means for a Natural Cubic Splines Analysis |
| ncs_mmrm_fit | Create a Mixed Model with Repeated Measures Using Natural Cubic Splines. |
| ncs_plot_means | Plot Actual and Predicted Response Variable Means by Study Arm. |
| ncs_plot_means_subgroup | Plot Actual and Predicted Response Variable Means by Study Arm and Subgroup. |
| percent_slowing_using_change_from_bl | Calculates Percent Slowing from a Data Frame of Change-from-Baseline Data |
| plot_outcome_by_visit_and_group | Plot Outcome Variable by Timepoint and Study Arm |
| splinetrials_analysis-class | 'splinetrials_analysis' object |
| splinetrials_subgroup_analysis-class | 'splinetrials_subgroup_analysis' object |
| time_spline | Create Natural Cubic Spline Approximations for Continuous Time |
| time_spline_basis | Natural Cubic Spline Basis Matrix for Continuous Time. |
| treatment_effect | Calculate the Change from Baseline or Treatment Effects from Estimated Marginal Means |